Antitumor/immunocompetent health foods

Healthy foods having both antitumor activity and activation effect for cell regeneration ability, comprising mycelia of mushrooms and one or plurality of oxidation preventive enzymes, preferably, at a blending ratio of 30 to 50% by weight of mycelia and from 65 to 45% by weight of one or a plurality of oxidation preventive enzymes in one embodiment, mycelia of mushrooms one or plurality of oxidation preventive enzymes and calcium added thereto, preferably, at a blending ratio of 30 to 50% by weight of mycelia, from 65 to 45% by weight of oxidation preventive enzymes and from 0.5 to 3% by weight of calcium in another embodiment, the oxidation preventive enzymes being preferably prepared by fermenting and ripening vegetables, fruits and rood crops, and one or plurality of lytic enzymes being possibly added to the healthy foods.

EXAMPLES Mycelia of Shiitake Shiitake fungi were re inoculated to solid medium for culturing shiitake, ripen by cultivating the hypae for 3 months, and subjected to liquefication to obtain 200 g of Shiitake mycelia powdered in an activated state as it was. Oxidation Preventive Enzyme 100 g of yeast, 500 cc of water and 100 g of maltose were added to a mixture of broccoli, lettuce, apples, carrots and beats in an amount of 1 kg in total and fermented and ripened. Liquid extracts obtained from the product were adsorbed to 200 g of wheat powder, dried and subsequently powdered by a grinder to obtain 200 g of powdery oxidation preventive enzymes. Calcium Commercially available calcium preparation (powder) purified from kelp as the raw material was provided. 49 g of mycelia of shiitake, 50 g of oxidation preventive enzymes and 1 g of calcium were charged into a stirrer, stirred and mixed at 60 rpm for 10 min to prepare 100 g of powdery healthy foods of this invention in the purified form. The result of the analysis for the ingredients of the healthy foods obtained as described above were as shown below. Result of Analysis for the Ingredients of Healthy Foods 1 Moisture (air oven method) 2.4 g/100 g Protein 7.1 g/100 g Fat (Method with acid hydrolysis) 1.5 g/100 g Ash 2.9 g/199 g Carbohydrates 86.1 g/100 g Energy 386 kcal/100 g Sodium 218 mg/100 g Iron 2.47 mg/100 g Calcium 843 mg/100 g Magnesium 53.0 mg/100 g Thiamin (as thiamin hydrochloride) 0.07 mg/100 g Rivoflavin 0.06 mg/100 g Calciferol not detected (LD 30IU/100 g) &bgr;-glucan 0.4 g/100 g Superoxide scavenging activity 140 unit g 
 Test Example Then, clinical test example of the healthy foods having antitumor/immunoactive ability described above of this invention is shown below. 
 Test Example 1 Name of disease: Gliomatosis cerebri Patient: Woman aged 36 at the time of crisis Hospital: Ageo Chuo General Hospital/neurosergery section Clinical Recording: Jul. 19, 1995: Craniotomy extraction operation of tumor was applied. Then, chemotherapy of anticancer drugs was applied. October, 1995: She could not drive a car because of the structure of visual field. March, 1996: As a result of MRI inspection, recidivation of tumor was observed in the vicinity of the place where the tumor was extirpated. Since no effects of anticancer drugs were observed, she was notified that the reminder of her life would be one-half year. Treatments including chemotherapy such as of interferon and radiotherapy were applied but further treatments were postponed till the finding of new treatment method because they provide no therapeutical effects. Jun. 23, 1996: Therefore, the patient orally intook the healthy foods containing oxidation preventive enzymes of this invention shown in the examples described above (hereinafter referred to as healthy foods of this invention) by from 10 g to 15 g per one day. After 4 days from the start of administration, the progressing stricture of the visual field was stopped, and the visual field was started to recover. December, 1996: As a comparison of the MRI inspection with that of the last time, no change was observed in the size of the tumor, and it was found not to be grown. The amount of the healthy foods of this invention to be administrated was reduced to one-half for examining the progress of the tumor. March, 1997: It was confirmed by an MRI inspection that the recidivated tumor was completely annihilated, and the administration of the healthy foods of this invention was stopped from since to observe prognosis. Sep. 22, 1998 : Shi was completely recovered by the finding of MRI inspection. Jan. 19, 2000: No abnormality according to the finding of MRI inspection test. Present state: The patient has not intake any enzymatic foods of this invention since March 1997 up to now for four years and she leads daily life not different from those of healthy housewives of other families. 
 Test Example 2 Name of disease: Multiplue Sclerosis Patient: Woman aged 27 at the time of crisis. Hospital: Tokyo University Hospital/neurointernal medicine section. Clinical Recording: January, 1998: Paralytic feeling began at first in hands and feet and the numbness was propagated to the whole body in October of the year. She tried inspections such as MRI inspection in the neurosurgery section of the Chiba Tokushu Kai Hospital but since the diagnosis could not be determined. She was examined again by the nuerointernal medicine section of the Hospital of Tokyo University. As a result, abnormalities were observed in her brain by MRI inspection for the head, and also in tibia by MRI inspection for legs, and she was diagnosed as suffered from multiple sclerosis and strongly recommended for admission to hospital. However, she did not enter the hospital since there were no therapeutic methods or medicines at present and, in addition, she could not be absent from her office for a long period of time. October, 1998: She began to orally intake from 10 g to 20 g of the healthy foods of this invention per one day, and then the numbness of hands and feet and sense of exhaustion were eliminated since the middle of November, and a sign of recovery was observed. Mar. 26, 1999: The abnormality of her brain disappeared as a result of MRI inspection in the Hospital of Tokyo University. In addition, it was analyzed that the shadow in the tibia was thinned. At this time, the amount of the enzymatic foods of this invention to be intaken was reduced to one half (10 g/day). Dec. 10, 2000: As a result of the final diagnosis, all of the shadows in the brain and the tibia were eliminated completely, and she was recovered completely according to the result of MRI inspection in the hospital, so that there was no requirement for her to intake the healthy foods of this invention and she has not intake them at all at present. Present state: The patient enjoys healthy daily life while working in her office with no worry. Since the antitumor/immunoactive healthy foods of this invention comprise the mycelia of mushrooms mixed with the oxidation preventive enzymes, it is considered that the polysaccharides (mainly &bgr;-glucanes) contained by a great mass to the mycelia of mushrooms gave damages to cancer cells, while cells in the plastic state recovered regeneration ability and were provided with immunocompetence by the oxidation preventive enzymes, thereby reducing or annihilating the cancer cells. The effects of the healthy foods of this invention is provided by the synergistic effects of the ingredients described above and, particularly, the regenerating ability of the cells is recovered since polysaccarides such as &bgr;-glucanes give damages to the cancer cells and ingesta such as carbonhydrates and proteins are supplemented to the cells under the effect of antioxidation. When calcium is added to the healthy foods described above, an antioxidation ability of cells can further be enhanced, to further improve the immunoactivity. Various kinds of lytic enzymes are contained in the mycelia of mushrooms. Therefore, since polysaccharides, oxydoreductase and calcium as the components of the healthy foods are effectively intaken and absorbed into the cells, the antitumor components, and the antioxidation components act satisfactorily to improve the tumor suppressing effect.