Powder inhaler having magazine storage and a hinged mouthpiece

The invention relates to an inhaler for the inhalation of powdered, more particularly micronised drug preparations from capsules, the housing 10 of the inhaler containing tubular chambers 15 for receiving and holding the capsules, in a revolver magazine with an air inlet at the bottom and an air outlet 25 at the opposite end of the chamber opening into a mouthpiece 11, and a cutting device 19 with two blades 21 which are movable into the interior of the chamber in order to open the capsules near the top and bottom ends thereof.

BACKGROUND OF THE INVENTION 
The invention relates to an inhaler for the inhalation of powdered, more 
particularly micronised drug preparations from capsules, the housing of 
said inhaler containing a tubular chamber for accommodating and holding 
the capsules, the chamber having an air inlet at the base and an air 
outlet at the opposite end merging into an inhalation mouthpiece, and a 
cutting device having two blades which are movable in to the interior of 
the chamber in order to open the capsules near the upper and lower end 
thereof. 
DESCRIPTION OF THE RELATED ART 
U.S. Pat. No. 2,569,720 describes an inhaler having a chamber in which 
powdered drug preparations are distributed and through which air flows 
when the user inhales. To prevent the powdered drug from getting into the 
mouthpiece connected to the air outlet of the chamber, a seive of suitable 
mesh size is provided at this point. A disadvantage of this inhaler, 
however, is that the capsule containing the drug preparation, which 
usually consists of hard gelatine, has to be opened by hand before use and 
the powdered drug preparation--with or without the capsule--has to be 
introduced into the chamber; then the inhaler has to be assembled. 
U.S. Pat. No. 3,918,451 relates to an inhaler, the outer housing of which 
has an opening which can be moved by rotation of the casing about the 
longitudinal axis of the housing into a position such that the chamber is 
freely accessible from the side and the interior of the chamber can be 
filled or cleaned. After the capsule has been inserted the chamber is 
closed by rotation of the outer casing, before two cutters of a cutting 
device are actuated which serve to open the capsule at top and bottom. 
Moreover, U.S. Pat. No. 4,069,819 describes an inhaler, the chamber of 
which is supposed to be constructed so that a capsule located therein is 
set rotating, moving up and down and vibrating by the air flowing through, 
in order to ensure uniform distribution of the powdered drug. 
The inhaler described in EP 0147755A2 is based on the same principle. The 
chamber thereof is substantially cylindrical and has an air inlet and an 
air outlet arranged coaxially at the bottom and top ends, respectively, 
the openings of which are smaller than the diameter of the capsule. This 
inhaler not only enables more reliable dispensing of the drug preparation 
with a small standard deviation, but has the additional disadvantage that, 
on actuation, it breaks up the powder in the capsule more satisfactorily. 
However, a disadvantage of this inhaler and of the other inhalers 
described previously is that before or after each inhalation process the 
single chamber has to be emptied or cleaned out, which requires the 
releasable or displaceable parts of the housing to be opened or taken 
apart beforehand. 
SUMMARY OF THE INVENTION 
The aim of the present invention is therefore to improve the inhaler 
described hereinbefore so that it is substantially easier to handle, 
introduction of the capsule into the tubular chamber before the next 
inhalation process is made easier without any great technical complexity 
and a capsule supply for immediate use is made available. This aim is 
achieved with the inhaler described in claim 1. According to the 
invention, instead of a single chamber in which a capsule has to be 
inserted or from which the capsule has to be removed, a revolving magazine 
is provided which has a plurality of tubular chambers each containing one 
capsule, which can be swung into position between the air inlet and outlet 
and thus forms part of the through-passage for the inhaled air. After 
inhalation has ended the revolving magazine is rotated further until the 
next chamber moves into the air through-passage. There is no need to open 
the housing or laboriously change the capsule or clean the chamber. 
Furthermore, the device has the advantage that it can be operated by one 
hand. 
According to a further feature of the invention the revolving magazine is 
releasably mounted in the inhaler housing. After the capsules present in 
the revolving magazine have been used up, the complete magazine can be 
replaced or refilled with capsules. 
According to another feature of the invention the inhaler housing has an 
eccentrically mounted pin onto which the revolving magazine can be fitted. 
In order to fix the position of the revolving magazine, it may be provided 
with recesses each associated with the capsule chambers for a locking bolt 
resiliently mounted in the inhaler housing. The recesses are arranged so 
that the locking bolt only engages when one of the capsule chambers is 
located precisely between the air inlet and outlet. 
This ensures that the revolving magazine does not move out of place during 
the inhalation process. The resilient mounting of the locking bolt should 
be arranged, with respect to the spring constant, so that accidental 
rotation of the revolving magazine is prevented by the locking action but 
on the other hand when greater force is applied the revolving magazine can 
be rotated out of the locked position. A conical configuration on the free 
end of the locking bolt and correspondingly shaped recesses help with 
this. 
The locking bolt is preferably arranged coaxially with respect to the air 
passage below the capsule chamber and has a through-bore which 
simultaneously forms the air inlet at the bottom. Preferably, the locking 
bolt is centrally mounted in the inhaler housing. According to a further 
embodiment of the invention the locking bolt is acted upon by a spring the 
other end of which rests on a plug releasably secured in the inhaler 
housing which also has a central through-bore which forms part of the air 
passage. 
The height of the capsule chamber is determined by the length of the drug 
capsules. Accordingly, the blades of the cutting device, which are movable 
into the interior of the chamber counter to the force of a spring, are 
arranged in the region of the top and bottom ends of the capsule chamber. 
The side wall of each capsule chamber has outer radial openings facing the 
blades, in the region of the top and bottom ends of the chamber, or at 
least frangible regions which serve to allow the blades to cut through. 
As already stated, the mouthpiece of the inhaler is in the form of a cap 
located on the lower part of the inhaler. It may be hinged to the edge of 
the inhaler housing so as to be pivotable about an axis extending 
perpendicularly with respect to the longitudinal axis of the inhaler. The 
mouthpiece and lower part of the inhaler housing may also, however, be 
secured to each other by a conventional push-fit connection. The 
releasability or pivotability of the two parts in any case greatly 
improves access in general, on the one hand to the revolving magazine and 
the cutting device in the lower part of the housing and, on the other 
hand, to the internal parts such as the seive plate and the upper part of 
the housing (of the cap in the form of a mouthpiece). 
In order to replace the used capsules by fresh ones, the mouthpiece is 
flipped up or the push bit connection between the mouthpiece and the lower 
part of the housing is undone. The chambers of the magazine are then 
freely accessible, so that the empty capsules can be taken out and full 
ones inserted. However, the magazine may also be pulled out and, after 
being emptied, may be refilled with fresh capsules and put back. The 
device is then flipped shut or reassembled. In the upper region of the 
chamber, where it merges into the inhalation channel, there is a seive 
plate which is part of a funnel-shaped connecting member which can be 
fitted on to the start of the inhalation channel in such a way that the 
edge of the funnel engages with the seive plate in an insert plate which 
forms the bottom of the mouthpiece. However, the seive plate may also be 
replaceably clamp-fitted between the funnel edge of the connecting member 
and an abutment of the insert plate. It prevents a capsule from blocking 
the air outlet opening when the user inhales and also ensures that any 
fragments of capsule which may be produced are not sucked into the 
mouthpiece. 
In a preferred embodiment, the recesses for the engagement of the locking 
bolt at the bottom end are provided in the base plate of the magazine 
concentrically with respect to the air inlet bores of the capsule chambers 
and are shaped like the outer shell of a flat truncated cone with its base 
turned outwards. In other words, these recesses are conical or funnel 
shaped expansions of the air inlet bores, the widened part facing the 
locking bolt. The sloping surfaces formed by this widening correspond 
substantially to the slopes on the head of the locking bolt. 
In a preferred embodiment, these recesses comprise, on the base of the 
truncated cone surface but still in the base plate, an encircling abutment 
edge which serves to prevent rotation or acts as an abutment for the head 
of the locking bolt when the bolt is engaged in the recess. This abutment 
edge consequently prevents the magazine from being rotated further when 
the locking bolt is engaged. 
According to another feature of this embodiment, the above mentioned 
abutment edge takes up only part or half of the circumference of the 
conical recess, i.e. the funnel shaped expansion, and is arranged so that 
it prevents the magazine from rotating in one direction when the locking 
bolt is engaged, but allows it to rotate in the opposite direction since 
the sloping wall of the funnel shaped expansion of the recess merges 
smoothly into the outside of the base plate. 
In another preferred embodiment, only one of the recesses has an abutment 
edge which takes up the entire circumference of the recess, with the 
result that, when the locking pin is engaged in this recess, it is 
impossible for the magazine to rotate. This position is then regarded as 
the end position of a magazine in which all the capsules have been used 
up. In this embodiment, all the other recesses have rotation prevention 
means only on one side, i.e. acting in one direction, so that the magazine 
can only ever be rotated in the direction of insertion of a capsule 
chamber containing an unused capsule until the end position described 
above is reached, in which the magazine is totally locked in position. The 
user then knows that the magazine has to be loaded with fresh capsules 
when this last capsule has been used. 
In another preferred embodiment, the blades of the cutting device are 
guided in a resiliently mounted sealing plate. This improves the seal 
between the capsule chamber in the position for inhalation and the cutting 
device. The spring which resets the operating button of the cutting device 
can be used for the resilient mounting of the sealing plate. 
In another preferred embodiment, a tongue may be secured to the locking 
bolt, extending as far as a stop on the inside of the operating button of 
the cutting device when the locking bolt assumes its upper position of 
abutment with the revolving magazine removed. This tongue acts as a 
barrier to the cutting device in this position. When the magazine is 
inserted, the locking bolt is pressed down again and moves the barrier 
away from the cutting device. 
Finally, in another preferred embodiment of the inhaler, a lever system is 
provided for actuating the cutting device. This lever system is preferably 
operated by an actuating button mounted on the base of the housing. The 
lever system may consist of a rocker arm and a toggle lever, the actuating 
button acting on one end of the rocker arm whilst the other end of the 
rocker arm presses on one end of the toggle lever, whilst the other end of 
the toggle lever, fixed to the cutting device, moves the cutting device 
forward. The rocker arm and toggle lever are preferably mounted so as to 
be pivotable about axis in holders secured to the housing. The actuation 
of the cutting device by means of this lever system may also be coupled to 
the rotary movement of the capsule magazine, so that the press of a button 
will first move a capsule chamber into the correct position and will then 
actuate the cutting device. 
If the revolving magazine and the part of the inhaler housing adjacent to 
it are of N-angled construction, where N is an integer which gives the 
number of capsule chambers, the lateral surfaces of the inhaler housing 
part and the revolving magazine will advantageously be aligned when the 
magazine is in the correct position. It is then immediately apparent from 
outside whether the chamber is located in the air channel defined by the 
air inlet and air outlet. 
According to a further feature of the invention, the inhaler has at least 
one cavity with openings at top and bottom below the revolving magazine. 
The openings at the bottom form a connection with the air inlet at the 
bottom. This embodiment ensures that sufficient air reaches the air inlet 
during inhalation. 
Preferably, the internal width of the capsule chambers is about 1.1 to 2 
times as large as the capsule diameter and the total length of the capsule 
chamber is about 1.1 to 1.6 times as long as the capsule length, whilst 
the internal width must be less than the length of the capsule to prevent 
the capsule from tipping over. Obviously, it is only possible to clamp the 
capsule in the revolving magazine if the air inlet opening in the base of 
the cavity is smaller than the diameter of the capsule. At the top, the 
cavities may be open, may have an air outlet which also tapers or they may 
be covered by a sieve plate.

DESCRIPTION OF PREFERRED EMBODIMENTS 
As can be seen from FIGS. 1a, 1b and 2a, the inhaler consists essentially 
of an inhaler housing 10 with a mouthpiece 11 which is laterally hinged to 
the upper edge of the inhaler housing so as to be pivotable about an axis 
12. Capsules are received in chambers 15, 15'(FIG. 4) in a revolving 
magazine 13 which can be placed on a pin 14 eccentrically mounted on the 
inhaler housing 10. After the revolving magazine 13 has been fitted in 
position, the mouthpiece 11 is moved into its normal position, as a cap on 
the housing; the inhaler is ready for use. As FIG. 2b shows, the revolving 
magazine 13 has six chambers 15 for receiving the capsules (not shown). 
The bottom of each chamber 15 has an air inlet bore 16. The revolving 
magazine 13 also has an axial guide 17 for the pin 14. 
As can be seen from FIG. 3, the inhaler has, adjoining the chamber 15 
arranged below the inhalation channel 33, a cutting device 19 which is 
operable by means of an actuating button 20. This cutting device 19 has 
two blades 21 which can be introduced radially into the top or bottom part 
of said chamber 15, the outer wall of the revolving magazine having 
perforations or frangible areas 22 situated at corresponding points to 
make it easier for the blades 21 to pass through. The blades 21 serve to 
open the capsule located in a chamber 15, near the upper or lower end of 
the capsule. The revolving magazine 13 also has, underneath the bores 16, 
conical recesses 23 in which a locking bolt 24 can engage as soon as a 
chamber 15 is coaxial with the air inlet 18 or inhalation channel 33 of 
the inhaler housing. 
The locking bolt is also of conical construction at its end which engages 
in the recess 23. At the opposite end it is acted upon by a spring 26 
which bears on a plug 27 releasably secured in the inhaler housing. This 
plug, like the locking bolt, has a central through-bore which serves as an 
air inlet 18. The internal width of the chamber 15 is about 1.1 to 2 times 
as great as the capsule diameter and the length of the capsule chamber 
(including the air outlet 25) is approximately 1.1 to 1.6 times the 
capsule length. However, the internal width of the chamber is less than 
the length of the capsule. 
In order to prepare the inhaler, the revolving magazine 13 is inserted and 
one of the chambers 15 is moved by rotation of the revolving magazine into 
a position where the bore 16 at the bottom or the conical recess 23 is 
aligned so as to be coaxial with the air inlet opening 18. The adjustment 
of the chamber 15 is made easier by the engagement of the locking bolt 24 
in the recess 23. After the bolt has clicked into place the air inlet 
opening 18 and the bottom opening 16 of the chamber 15 are in alignment. 
The cap of the capsule is located on the bottom opening 16 and closes it 
off. By actuating the operating button 20 counter to the force of a spring 
28, the blades 21 are moved radially towards the chamber 15, and first of 
all they pass through the frangible regions 22 or enter into suitable 
openings provided in the side wall of the revolving magazine and finally 
they open the capsule at top and bottom close to the ends thereof. The 
hemispherical caps of the capsules should not be destroyed, as they are 
supposed to act as a sort of valve. 
In order to facilitate the severing of the frangible regions 22, the 
corresponding places are preferably offset so that the upper blade has to 
pass through the frangible region before the lower blade reaches it. 
If air is then taken in through the mouthpiece 11, the air flowing into the 
chamber 15 from the openings 29 at the bottom of the housing 10 and from 
the inlet 18 cause the capsule to vibrate violently, whips up the powder 
in the capsule, becomes mixed up with the powder and is finally inhaled. 
The mouthpiece 11 is generally of tubular construction but may also be 
adapted to fit the shape of the mouth and be of flattened construction. As 
a variant of this embodiment, it is also possible to have axial mouthpiece 
arrangements or arrangements which are offset at an angle to the axis of 
the chamber of laterally with respect to the axis of the chamber. 
Whereas, in the embodiment shown in FIG. 3, the mouthpiece or cap 11 is 
provided at the bottom with a substantially closed insert plate 30, the 
insert plate 30 according to FIG. 4 has openings 31. Furthermore, in the 
embodiment shown in FIG. 4, the start of the inhalation channel 33 is 
covered with a seive 32 which prevents the capsule or fragments thereof 
from entering the inhalation channel 33 in the mouthpiece during 
inhalation. As an alternative, wall projections may be provided at this 
point to hold the capsule back. The sieve plate 32 is preferably arranged 
in the centre of the insert plate 30, and is advantageously clamped 
between a stop 37 of the plate 30 which comprises the air passage and the 
edge of a funnel shaped connecting member 38, which is fitted on the start 
39 of the inhalation channel 33 in such a way that the funnel edge faces 
the insert plate 30 and engages therewith. The projections provided as an 
alternative may also be arranged at this point. 
Furthermore, the inhaler housing 10 may have openings 34 in the side facing 
the revolving magazine 30 or the bores 16 thereof, these openings 34 
terminating in an annular cavity 35 in the housing which is able to 
communicate with the air inlet 18 at the bottom. 
FIGS. 2c, d and e show a preferred embodiment of the locking means for the 
revolving magazine. FIG. 2c shows a view of the base plate 40 of the 
revolving magazine 13. FIGS. 2d and 2e show enlarged partial sections 
through the position of engagement of the locking bolt 24 in the base 
plate 40 of the preferred embodiment of the base plate 40 according to 
FIG. 2c. As can be seen from FIG. 2c, a concentric surface or slope 
designated 43 and 41 is arranged around each bore 16. This surface is 
supposed to be the exit contour of the funnel-shaped widening of the bore 
16 in the base plate 40. FIG. 2e shows the particular configuration of 
this exit contour more clearly. On the one hand it has a slope 43 which 
merges smoothly with the surface of the base plate 40 and on the opposite 
side it has an edge 42 (FIG. 2d) which describes a smaller radius. The 
edge 42 constitutes a stop for the locking bolt 24 and prevents the 
magazine from rotating against the edge 42. However, the magazine may also 
readily be rotated in the direction of the slopes 43 as shown in FIG. 2c. 
Also as shown in FIG. 2c, the abutment edges 42 extending over half the 
circumference of the conical expansion are arranged in the same direction, 
i.e. they prevent the magazine from rotating in the same direction and 
allow it to rotate only in the direction of the arrow over the slopes 43, 
which are shown with a larger diameter in FIG. 2c. The positions shown in 
FIG. 2c are designed a to h. The conical recess in position a has the 
special feature of having a stop edge 42 which extends over the entire 
circumference. In other words, in position a, the locking bolt 24 would 
not allow the magazine to rotate in any direction. Consequently, for the 
user, this position is the end position in which all the capsules in the 
magazine have been used up and have to be replaced by fresh capsules. In 
positions b to h the recesses are constructed in the manner just 
described, in which the magazine can rotate only in the direction of the 
arrow. This prevents any capsule which has already been used from being 
returned to the inhalation chamber. 
FIG. 5 shows an embodiment of the inhaler with a resiliently mounted 
sealing plate 44 for the blades 21 and a barrier 45 for the operating 
button 20. The guiding of the blades 21 in a sealing plate 44 which is 
separate and detached from the housing improves and aids the sealing off 
of the space containing the cutting mechanism from the inhalation chamber. 
The sealing plate 44 can be pressed against the sealing surfaces by means 
of the same spring which causes the operating button 20 of the cutting 
device 19 to be reset. 
The barrier 45 for the operating button 20 is preferably connected to the 
locking bolt 24. It performs its blocking action when the locking bolt 24 
has reached its upper stop position against the stop 46, with the 
revolving magazine 13 removed. When the revolving magazine is put in, the 
locking bolt 24 is pressed down again and the tongue 45 is also moved out 
of the blocking area. 
The embodiment shown in FIG. 6 shows a lever system 47, 48 for actuating 
the cutting device 19 by means of an operating button 49 mounted in the 
base of the housing. The first lever 48, in the form of a rocker arm, 
presses on the short end of the toggle lever 47 when the operating button 
49 is pushed upwards, whilst the long end of the toggle lever 47 acts on 
the cutting device 19. The rocker arm 48 and toggle lever 47 in the 
embodiment shown are mounted in holders 50 so as to be pivotable about the 
axis 51. This embodiment can also be arranged so that actuation of the 
button 49 simultaneously rotates the capsule magazine 13 and then 
activates the cutting device 19.