An autoinjector device includes an elongate housing containing a syringe or cartridge having an internal piston for expressing a dose from the syringe or cartridge. A drive mechanism includes a drive member engaging the piston and a drive spring acting on the drive member. A side-operated trigger arrangement includes a retention element movably mounted in the housing from a retaining position in which the drive member is kept in a cocked condition, and a release position in which the drive member may more forwardly under spring pressure. An outer sleeve is mounted on the housing movable between a position in which the retention element is prevented from moving to release the plunger, and a position in which the retention member moves freely. The outer sleeve includes a trigger wall portion which may be depressed to move the retention element once the retention element is free to move, releasing the plunger.

This invention relates to autoinjector devices having a drive mechanism including a trigger arrangement operable to release a plunger to move forwardly relative to the device to expel a dose.

In our earlier publication WO94/21316 we disclose an arrangement in which a sleeve is slideably mounted on the rear end of the autoinjector housing, and has an aperture through which a laterally facing trigger is exposed. The trigger is hingeably mounted by live hinges to the main housing and has latch hooks which latch the drive plunger of the device against forward movement, with the hooks and trigger thereby reacting the load of the compressed drive spring. The external sleeve can be moved against a spring bias from a safe position in which it inhibits operation of the trigger, and an armed position in which the trigger may be operated to release the plunger. Although this design has proved extremely successful in practice, particularly for reusable devices, the present inventors have developed certain improvements.

In particular, in the above design, the trigger reacts the drive load when the device is cocked, and this places significant design constraints on the trigger. We have therefore designed a side actuated mechanism in which the load of the drive spring when the device is cocked is reacted by a separate reaction element. Although usable in autoinjectors in general, this feature is particularly appropriate for single use autoinjectors that are supplied in a cocked condition and in which the retention element is therefore under load for many months or years. Also, in the prior art arrangement, mounting the manually operable trigger on the housing means that a large aperture has to be provided in the sleeve which is undesirable.

Accordingly, in one aspect, this invention provides an autoinjector device comprising:

an elongate housing containing a syringe or cartridge having an internal piston for expressing a dose from the syringe or cartridge, a drive member for engaging said piston, and a drive energy source acting on said drive member;

a retention member movably mounted with respect to said housing for movement between a retaining position in which the drive member is kept in a cocked condition with the drive energy source energised, and a release position in which the drive member is free to move under the influence of the drive source, and

an outer sleeve movably mounted with respect to said housing, said outer sleeve having associated therewith a trigger element movable to urge said retention member and to move it to its release position, and the outer sleeve being movable between a safe state in which said retention member is prevented from moving to its release position, and a ready state in which the retention member is free to move to its release position when urged by action of said trigger element.

In the above arrangement the trigger element may form part of the outer sleeve rather than the housing. This means that the trigger element may form integrally with the outer sleeve, without requiring a separate aperture. Furthermore, the retention member carries the load on the plunger when cocked, and the trigger element itself is not subject to load when the device is cocked.

Conveniently said retention member and said housing have respective cooperating abutments at least one of which is resiliently movable between a safe position in which movement of said retention element to said release position is prevented, and a ready position in which movement is allowed. In this case, movement of said sleeve from its safe to its ready state preferably causes said resiliently movable abutment to move to its ready position. Such movement may be achieved by providing the sleeve with a surface for engaging said resilient abutment. Thus said surface may be a camming surface.

Whilst the invention has been described above, it extends to any invention combination of the features set out above or in the following description or drawings.

Referring initially toFIGS. 1 to 3, the embodiment of autoinjector this invention comprises an outer housing10containing a syringe12with a needle14mounted in a syringe carrier16for forward movement. A drive plunger18is shown latched in a cocked position against the force of a main drive spring20. The drive plunger is releasably held in its cocked position by means of a retention plate22e.g. of plastics material. Slideably mounted on the outside of the housing10is an external sleeve24which is biased rearwardly by a sleeve spring26. When the sleeve24is shifted forwardly on the housing, a trigger28may be pressed inwardly to shift the retention plate22to release the plunger thereby extending the syringe and expelling a dose.

Referring now more particularly toFIGS. 3 and 4, and to the trigger mechanism, the drive plunger has at its rear end a reduced diameter neck30topped by a head32to form a T-shape as seen more particularly inFIGS. 4(c) and (d). The head32has V-shaped contact surfaces34that seat in a plunger indexing rebate36in the retention plate22when the device is cocked. The retention plate has a D-shaped plunger retaining aperture38which merges with an enlarged plunger release opening40. Two resilient integral latch arms42extend from one side of the plate down its sides. A slot44is provided to cooperate with a peg46on the housing to constrain movement of the retention plate. The outer housing10also includes two abutments48that cooperate with the latch arms42on the retention plate22to prevent movement of the retention plate between its retaining position (as shown inFIGS. 1 to 3) and its release position, where the plunger18is released for forward movement.

Internally of the rear end of the sleeve24are two spaced de-latching elements50having inclined forward camming surfaces52. These de-latching elements are best seen inFIGS. 6(a) to (f)and are designed to cooperate with and squeeze the latch arms42against the sides of the retention plate22to release them from engagement with the abutments48, when the sleeve24is shifted forwardly on the housing. Once the latch arms42are clear of the abutments, the retention plate22can be shifted to release the plunger when the trigger wall portion28is pressed inwardly.

Thus, in operation, a user will prepare the autoinjector by removing a cap54at the front end thereby also removing a needle shield56and preparing the device for injection. The device is then offered up to an injection site, with the front end placed in contact with the skin around the injection site. The sleeve24in the pressed so that it shifts forwardly on the outer housing with the de-latching elements50squeezing the latch arms42clear of the abutments48, as seen in sequence inFIGS. 6(a) to (f) and 7(a), (b) and (c). When the user is ready, they press the trigger wall portion28inwardly, thereby shifting the retention plate22so that it releases the drive plunger18so that it shoots forwardly under the influence of the drive spring20.

In this arrangement, the drive spring load is taken by the retention plate which itself is separate from the trigger. This means that the trigger wall portion does not have to sustain the load of the drive spring and can be of lighter construction. A further advantage is that, in the arrangement as described, the restraining load provided by the retaining plate is symmetric about the longitudinal axis of the plunger and so the retention forces are balanced.