MULTIFUNCTIONAL PIPETTE AND AUTOMATIC DETECTION MACHINE

A multifunctional pipette includes a pipette module, a heater module and a magnetic module. The pipette module includes one or more pipette heads. The heater module has a first joint part, and the heater module configured to removably connect to the pipette module by coupling the first joint part to at least one of the plurality of pipette heads. The magnetic module has a second joint part, and the magnetic module configured to removably connect to the pipette module by coupling the second joint part to at least one of the plurality of pipette heads. The multifunctional pipette can be further applied in an automatic detection machine.

CROSS-REFERENCE TO RELATED APPLICATION

This non-provisional application claims priority under 35 U.S.C. § 119(a) to Patent Application No. 111149577 filed in Taiwan, R.O.C. on Dec. 22, 2022, the entire contents of which are hereby incorporated by reference.

BACKGROUND

Technical Field

The present disclosure relates to a pipetting device, and in particular to a multifunctional pipette and an automatic detection machine.

Related Art

In a detection experiment, pipettes are widely used by people to draw up a small volume of liquid and drop it into an experimental vessel. Thus, the pipette is an indispensable experimental instrument for laboratory workers to perform various experiments. Besides, in the laboratory analysis process, in addition to drawing up and dispensing liquid with the pipette, stirring, heating, mixing, magnetic suction and other actions may also be required, so many tools or instruments are often needed to help complete the actions required in the whole laboratory analysis process.

However, when the number of specimens to be detected increases, the manual method of laboratory analysis will be challenged. Therefore, how to develop an automatic detection device to meet the requirements of various detection experiments will be a problem that all parties will strive to solve.

SUMMARY

In an embodiment, a multifunctional pipette includes: a pipette module, a heater module and a magnetic module. The pipette module has a plurality of pipette heads. The heater module has a first joint part. The heater module configured to removably connect to the pipette module by coupling the first joint part to at least one of the plurality of pipette heads.

The magnetic module has a second joint part, and the magnetic module configured to removably connect to the pipette module by coupling the second joint part to at least one of the plurality of pipette heads.

In an embodiment, an automatic detection machine includes: a detection platform, a multifunctional pipette and a moving mechanism. The detection platform has a plurality of working areas. The multifunctional pipette includes: a pipette module, a heater module and a magnetic module. The moving mechanism is connected to the multifunctional pipette and configured to drive the multifunctional pipette to move between the working areas.

The pipette module has a plurality of pipette heads. The heater module has a first joint part. The heater module configured to removably connect to the pipette module by coupling the first joint part to at least one of the plurality of pipette heads.

The magnetic module has a second joint part, and the magnetic module configured to removably connect to the pipette module by coupling the second joint part to at least one of the plurality of pipette heads.

DETAILED DESCRIPTION

In some embodiments, the multifunctional pipette42includes: a pipette module1, a heater module2and a magnetic module3. When the heater module2is not connected to the pipette module1, the magnetic module3is removably connected to the pipette module1according to needs. When the magnetic module3is not connected to the pipette module1, the heater module2is removably connected to the pipette module1according to needs.

The multifunctional pipette42has three application states (hereinafter referred to as a first application state, a second application state and a third application state respectively). In the first application state, the multifunctional pipette42has a function of heating. In the second application state, the multifunctional pipette42has functions of providing magnetic force and stirring. In the third application state, the multifunctional pipette42has a function of transferring liquid.

The first application state will be described here. A multifunctional pipette42includes: a pipette module1and a heater module2(as shown inFIG.1andFIG.2, the part where the heater module2is mounted to the pipette module1is shown in the form of an exploded view).

The pipette module1includes: a plurality of pipette heads13, a plurality of piston assemblies12and a pipette shell11.

The pipette heads13respectively correspond to the piston assemblies12, and each of the pipette heads13is arranged at one end of the corresponding piston assembly12. Besides, the number of the piston assemblies12is the same as that of the pipette heads13. It should be understood that althoughFIG.1shows 8 piston assemblies12and 8 pipette heads13, the number of the piston assemblies12and the pipette heads13may be modified to other numbers according to actual requirements, such as 2, 3, 4, 5, 6, 7, 8 or more.

Referring toFIG.1andFIG.2, the piston assemblies12include a plurality of air channels122and a plurality of piston rods123. The piston rod123may be inserted into the air channel122from a first end of the air channel122and is removable in axially reciprocating manner in the corresponding air channel122. A second end of the air channel122has an opening121, and the opening121is connected to the corresponding pipette head13. In other words, each of the piston assemblies12is coupled to the corresponding pipette head13. Here, when the piston rod123reciprocates in the air channel122, i.e., when the piston operates, the piston assembly12can draw liquid into a micropipette5or dispense the liquid out of the micropipette tip5.

In some embodiments, the air channels122of all the piston assemblies12can be integrated into a cylinder111(as shown inFIG.2, the cylinder111is located in the pipette shell11). The air channels122are located inside the cylinder111in parallel at intervals, and each of the air channels122runs through the cylinder111from top to bottom, so that the first end of each of the air channels122forms one opening on an upper surface of the cylinder111and the second end of each of the air channels122forms the other opening121on a lower surface of the cylinder111. The opening121is arranged close to one side of the pipette shell11. The pipette heads13are fixedly arranged on the pipette shell11.

Here, the heater module2includes: a first joint part2121, a plurality of power supply terminals14, a plurality of heating rods22, a plurality of first connecting terminals23and a heat-resistant shell21.

In some embodiments, the heater module2configured to removably connect to the pipette module1by coupling the first joint part2121to at least one of the plurality of pipette heads13. In detail, the plurality of pipette heads13define a plurality of first recessed parts211opposite to the plurality of pipette heads13. The first joint part2121has the plurality of first recessed parts211opposite to the pipette heads13. The plurality of first recessed parts211are respectively matched with the plurality of corresponding pipette heads13. Specifically, the distribution positions of the first recessed parts211are the same as the relative distribution positions of the corresponding pipette heads13on the pipette shell11, so that when the pipette module1and the heater module2are close to each other, the plurality of pipette heads13can be respectively and correspondingly inserted into the respective first recessed parts211. The first recessed part211is used to accommodate the pipette head13. The first recessed part211is configured to limit the pipette head13. For example, an inner surface of the first recessed part211is concave, which can avoid the offset of the heater module2assembled on the pipette module1, i.e., when the heater module2is assembled on the pipette module1, a central axis of each of the first recessed parts211coincides with a central axis of any pipette head13.

In some embodiments, the number of the first recessed parts211may be equal to or less than that of the pipette heads13. When the pipette heads13are coupled to the first recessed parts211one to one, the number of the pipette heads13and the number of the first recessed parts211are preferably each two or more.

The power supply terminals14are embedded in the pipette shell11. The power supply terminals14and the pipette heads13face the same direction. As shown inFIG.1andFIG.2, they all face the heater module2. In some embodiments, the power supply terminals14include a positive contact and a negative contact.

The first joint part2121is located at one side of the heat-resistant shell21. The first joint part2121and the plurality of heating rods22are arranged at different sides of the heat-resistant shell21. Preferably, the first joint part2121are arranged opposite to the plurality of heating rods22. Besides, the plurality of first connecting terminals23are embedded in the heat-resistant shell21, and the first connecting terminals23respectively correspond to the plurality of power supply terminals14and are electrically connected to the plurality of heating rods22. The first connecting terminals23and the first joint part2121face the same direction.

Here, the heating rods22are respectively aligned with the first recessed parts211. Specifically, a central axis of each of the heating rods22runs through a center point of the corresponding first recessed part211. In some embodiments, the number of the heating rods22may be equal to or less than that of the pipette heads13.

It should be understood that althoughFIG.1,FIG.2andFIG.4show eight first recessed parts211and eight heating rods22, the number of the first recessed parts211and the number of the heating rods22may be adaptively modified into other numbers according to actual requirements, such as 1, 2, 3, 4, 5, 6, 7, 8 or more.

The heat-resistant shell21further includes a fixed base212and at least two extending arms213. The fixed base212includes the first surface, a second surface2122, a third surface2123and a fourth surface2124. The first surface is the first joint part2121. Specifically, the first joint part2121and the second surface2122are arranged opposite to each other, and the third surface2123and the fourth surface2124are respectively connected between the first joint part2121and the second surface2122. The plurality of heating rods22run through the second surface2122. In some embodiments, the number of the extending arms213is two. One end of one of the extending arms213is connected to the third surface2123, and one end of the other extending arm213is connected to the fourth surface2124. The other end of each of the extending arms213and the first joint part2121face the same direction. As shown inFIG.1andFIG.2, they both face the pipette module1. Each of the first connecting terminals23is located at an end surface of the other end of the extending arm213. In some embodiments, the three-dimensional shape of the extending arm213is substantially an L shape.

In some embodiments, a tolerable temperature (i.e., a temperature that does not cause a change in the material of the heat-resistant shell21) of the heat-resistant shell21is greater than a heating temperature of the heating rods22.

Here, when the heater module2is removably assembled onto the pipette module1through the first recessed parts211being sleeved on the pipette heads13, the plurality of first connecting terminals23are respectively electrically connected to the plurality of power supply terminals14(as shown inFIG.3).

The pipette heads13are inserted and snapped into the corresponding first recessed parts211, so that the heater module2is assembled onto the pipette module1and an electrical contact of each of the power supply terminals14is attached and electrically connected to an electrical contact of the corresponding first connecting terminal23. Therefore, in the first application state, the pipette module1can drive the heating rods22on the heater module2through the electrical connection between the power supply terminal14and the first connecting terminal23, so that the heating rods22generate heat.

When liquid transfer is needed, the pipette heads13of the pipette module1are sleeved with the micropipette tips5, so that the liquid can be drawn into the micropipette tips5or dispensed out of the micropipette tips5through the piston assemblies12. When heating is needed, the micropipette tips5sleeved on the pipette heads13can be removed and the first recessed parts211are sleeved on the pipette heads, so that the heater module2is assembled onto the pipette module1. Similarly, when the liquid transfer is needed again, the heater module2sleeved on the pipette heads13is removed, and the micropipette tips5with required size are sleeved on the pipette heads again.

The second application state will be described here. The part of the magnetic module3mounted to the pipette module1is shown in the form of exploded views (as shown inFIG.5toFIG.8). Referring toFIG.5, the magnetic module3includes a second joint part311. The magnetic module3configured to removably connect to the pipette module1by coupling the second joint part311to at least one of the plurality of pipette heads13. Here, the structure and function of the pipette module1are basically the same as those of any of the aforementioned embodiments, and thus will not be described again. The magnetic module3includes: eight connecting sleeves31and eight permanent magnet rods32. The connecting sleeves31include the second joint part311. The second joint part311includes eight sleeve recessed parts3111, and the sleeve recessed parts3111are respectively located at one end of the connecting sleeves31. The eight pipette heads13define the eight sleeve recessed parts3111opposite to the pipette heads13. The eight sleeve recessed parts3111are respectively matched with the corresponding eight pipette heads13. A central axis of each of the connecting sleeves31coincides with a central axis of any pipette head13, so that when the pipette module1and the magnetic module3are close to each other, the pipette heads13can be inserted into the corresponding sleeve recessed parts3111one to one. The sleeve recessed part3111is used to accommodate the pipette head13. Besides, the eight permanent magnet rods32are respectively arranged at the other ends of the corresponding eight connecting sleeves31.

In some embodiments, the number of the connecting sleeves31may be equal to or less than that of the pipette heads13.

In some embodiments, referring toFIG.6, the magnetic module3includes: a fixed base33and eight permanent magnet rods34. The fixed base33includes the second joint part331and a second surface332opposite to each other. The eight pipette heads13define the eight second recessed parts3311opposite to the eight pipette heads13. The second joint part331has the eight second recessed parts3311, and the second recessed parts3311are matched with and sleeved on the corresponding pipette heads13. The eight permanent magnet rods34run through the second surface332, and the eight permanent magnet rods34are respectively aligned with the eight second recessed parts3311. A central axis of each of the eight pipette heads13coincides with a central axis of any of the second recessed parts3311. Specifically, the distribution positions of the second recessed parts3311on the fixed base33are the same as the relative distribution positions of the corresponding pipette heads13on the pipette shell11, so that when the pipette module1and the magnetic module3are close to each other, the pipette heads13can be inserted into the corresponding second recessed parts3311one to one. The second recessed part3311is used to accommodate the pipette head13. In some embodiments, the number of the second recessed parts3311may be equal to or less than that of the pipette heads13.

In some embodiments, referring toFIG.7andFIG.9, the magnetic module3includes: eight second recessed parts351located at the second joint part3521, two power supply terminals14arranged on the pipette shell11, eight electromagnet rods36arranged opposite to the second joint part3521, and two second connecting terminals37. The eight pipette heads13define the eight second recessed parts351opposite to the eight pipette heads13. The second connecting terminals37respectively correspond to the power supply terminals14and are electrically connected to the electromagnet rods36. Electrical contacts of the second connecting terminals37may be attached and electrically connected to electrical contacts of the corresponding power supply terminals14. Here, when the magnetic module3is removably assembled onto the pipette module1through the eight second recessed parts351being sleeved on the eight pipette heads13, the two second connecting terminals37are respectively electrically connected to the two power supply terminals14. The second connecting terminals37and the second joint part3521face the same direction. Besides, the distribution positions of the second recessed parts351on a connecting shell35are the same as the relative distribution positions of the corresponding pipette heads13on the pipette shell11, so that when the pipette module1and the magnetic module3are close to each other, the pipette heads13can be inserted into the corresponding second recessed parts351one to one. The second recessed part351is used to accommodate the pipette head13.

The second recessed parts3311,351(and the sleeve recessed parts3111) are configured to limit the pipette heads13. For example, an inner surface of the second recessed parts3311,351(and sleeve recessed parts3111) is concave, which can avoid the offset of the magnetic module3assembled on the pipette module1, i.e., when the magnetic module3is assembled on the pipette module1, a central axis of each of the second recessed parts3311,351(and sleeve recessed parts3111) coincides with a central axis of any pipette head13.

In some embodiments, the number of the second recessed parts3311,351(and sleeve recessed parts3111)/or the number of the electromagnet rods36may be equal to or less than the number of the pipette heads13. Although the figures show eight second recessed parts3311,351(and sleeve recessed parts3111) and eight electromagnet rods36, the number of the second recessed parts3311,351(and sleeve recessed parts3111) and the number of the electromagnet rods36may be adaptively modified into other numbers according to actual requirements, such as 1, 2, 3, 4, 5, 6, 7, 8 or more.

The magnetic module3further includes the connecting shell35. The eight electromagnet rods36are arranged at the other side of the connecting shell35and respectively aligned with the eight second recessed parts351. The two second connecting terminals37are embedded in the connecting shell35and respectively electrically connected to the eight electromagnet rods36.

In some embodiments, referring toFIG.9, the connecting shell35includes: a fixed base352and two extending arms353. The fixed base352includes a first face, a second surface3522, a third surface3523and a fourth surface3524. The first surface is the second joint part3521. The second joint part3521and the second surface3522opposite to each other, and the third surface3523and the fourth surface3524connected between the second joint part3521and the second surface3522. The eight second recessed parts351are arranged on the second joint part3521, and the eight electromagnet rods36run through the second surface3522. One end of one of the extending arms353is connected to the third surface3523, and one end of the other extending arm353is connected to the fourth surface3524. The other end of each of the extending arms353and the second joint part3521face the same direction. Each of the second connecting terminals37is located at an end surface of the other end of the extending arm353. In some embodiments, the three-dimensional shape of the extending arm353is substantially an L shape.

Therefore, in the second application state, the magnetic module3is removably connected to the pipette module1through the second joint part311,331,3521being coupled to at least one of the plurality of pipette heads13, so that the multifunctional pipette42has the functions of providing magnetic force and stirring. In one embodiment, the permanent magnet rod32is arranged at the other end of the corresponding connecting sleeve31, so that the pipette module1connected with the magnetic module3has the functions of providing required magnetic force and stirring (as shown inFIG.5). In another embodiment, the permanent magnet rod34is arranged on the fixed base33and coupled to the pipette head13via the second joint part331of the fixed base33, so that the pipette module1connected with the magnetic module3has the functions of providing required magnetic force and stirring (as shown inFIG.6). In still another embodiment, the pipette module1can be used to drive the electromagnet rod36on the magnetic module3through the power supply terminal14being electrically connected to the second connecting terminal37, so that the electromagnet rod36produces a magnetic field (as shown inFIG.7andFIG.8).

When liquid transfer is needed, the pipette heads13of the pipette module1are sleeved with the micropipette tips5, so that the liquid can be drawn into the micropipette tips5or dispensed out of the micropipette tips5through the piston assemblies12. When a magnetic field is needed in the operation process, the micropipette tips5sleeved on the pipette heads13can be removed and the second recessed parts351(or the second recessed parts3311, or the sleeve recessed parts3111) are sleeved on the pipette heads, so that the magnetic module3is assembled onto the pipette module1. Similarly, when the liquid transfer is needed again, the magnetic module3sleeved on the pipette heads13is removed, and the micropipette tips5with required size are sleeved on the pipette heads again.

In some embodiments, the power supply terminal14and the first connecting terminal23(and the power supply terminal14and the second connecting terminal37) may be realized as a spring probe (or pogo pin) and a guide plate that are matched with each other. For example, when the power supply terminal14is the spring probe, the corresponding first connecting terminal23(and the corresponding second connecting terminal37) is the guide plate. On the contrary, when the power supply terminal14is the guide plate, the corresponding first connecting terminal23(and the corresponding second connecting terminal37) is the spring probe.

In some embodiments, referring toFIG.10toFIG.12, the pipette module1further includes: a linear guide rail15and a linkage element16. The linkage element16connects the linear guide rail15with the piston assemblies12. Here, the linkage element16is used to drive the piston assemblies12to reciprocate along the linear guide rail15. Specifically, the linkage element16is coupled to the piston rods123of all the piston assemblies12. When liquid transfer is needed, the linkage element16can simultaneously pull the piston rods123of all the piston assemblies12out of the air channels122, so that the multifunctional pipette42can draw the liquid up into the micropipette tips5mounted thereon; or the linkage element16can simultaneously push the piston rods123of all the piston assemblies12into the air channels122, so that the multifunctional pipette42can dispense the liquid out of the micropipette tips5mounted thereon.

In some embodiments, referring toFIG.10toFIG.12, the pipette module1further includes: a limit assembly17. The limit assembly17is connected to the linkage element16. Here, the limit assembly17is configured to limit a moving distance of the linkage element16. Based on this, the multifunctional pipette42can accurately control the amount of liquid drawn up or dispensed.

In some embodiments, the limit assembly17further includes an upper limit member171and a lower limit member172, as shown inFIG.11. The upper limit member171is located at an upper limit of the moving range of the linkage element16, and the lower limit member172is located at a lower limit of the moving range of the linkage element16.

In some embodiments, the multifunctional pipette42may be an automatic type. Referring toFIG.10andFIG.11, the pipette module1further includes: a motor18. The motor18is arranged at one side of the pipette shell11. Here, the motor18can be used to drive the piston assemblies12.

For example, the motor18is coupled to the linkage element16. When the motor18pulls the linkage element16away from the pipette heads13, the linkage element16can move from the upper limit member171to the lower limit member172along the linear guide rail15, so as to pull the piston rods123of all the piston assemblies12out of the air channels122. When the motor18pushes the linkage element16close to the pipette heads13, the linkage element16can move from the lower limit member172to the upper limit member171along the linear guide rail15, so as to push the piston rods123of all the piston assemblies12into the air channels122.

In this way, the user can perform liquid transfer by controlling the start of the motor18.

In some embodiments, referring toFIG.12, the pipette module1further includes an exit structure19, a linking piece112, two screws113, two elastic elements114and two pushing elements115.

The exit structure19is located beside the pipette heads13. The exit structure19has a plurality of perforations191, and the number of the perforations191is the same as that of the pipette heads13. The following is an example of eight perforations191.

The eight perforations191are provided in the exit structure19, and the perforations191respectively surround the pipette heads13. The linking piece112is arranged above the cylinder111. One end of the linking piece112is connected to one of the screws113, and the other end of the linking piece112is connected to the other screw113. The cylinder111is arranged between the screws113. Horizontal positions of the two pushing elements115are the same as those of the screws113. The linking piece112is arranged between the pushing elements115and the screws113. The two screws113are respectively connected to the exit structure19. The two elastic elements114are respectively elastically arranged on the screws113. The linking piece112is arranged at a position where the piston assemblies12reciprocate. The piston assemblies12run through the linking piece112, and the piston assemblies12are partially located inside the cylinders111.

The linkage element16drives the eight piston assemblies12to reciprocate along the linear guide rail15. When the linkage element16moves to the lower limit member172along the linear guide rail15and abuts against the linking piece112, the linking piece112links the screws113and moves the screws113toward the exit structure19. At this time, since the exit structure19is coupled to one end of the screw113, the exit structure19may be separated from the pipette shell11due to the movement of the screw113, so as to push the object (for example, the micropipette tips5, the heater module2or the magnetic module3) snapped on the pipette heads13away from the pipette heads13. At this time, the elastic elements114are squeezed by the movement of the screws113, so that the elastic elements114store elastic potential energy.

When the linkage element16moves away from the lower limit member172along the linear guide rail15and no longer abuts against the linking piece112, the elastic potential energy stored by the elastic elements114is converted into kinetic energy of the object, so that the screws113are moved toward the pushing elements115and abut against the pushing elements115. At this time, due to the movement of the screws113, the exit structure19connected with the screws113is moved toward the pipette shell11and abuts against the pipette shell11. At this time, the exit structure19is located beside the pipette heads13.

In some embodiments, the multifunctional pipette42of an automatic type may be applied to an automatic detection machine4.

In some embodiments, referring toFIG.13, the automatic detection machine4includes a detection platform41, a multifunctional pipette42, a moving mechanism43and a receiving base44. The detection platform41has a plurality of working areas411. The moving mechanism43is connected to the multifunctional pipette42and configured to drive the multifunctional pipette42to move between the working areas411. In some embodiments, the moving mechanism43drives the multifunctional pipette42to move in an X-axis direction, a Y-axis direction and/or a Z-axis direction. Here, the structure and function of the multifunctional pipette42are basically the same as those of any of the aforementioned embodiments, and thus will not be described again. In addition, the automatic detection machine4is also equipped with a computer device.

In some embodiments, the automatic detection machine4further includes a receiving base44. The following is an example of10working areas411. The receiving base44is located in one of the10working areas411. The receiving base44can receive the heater module2and/or the magnetic module3, as shown inFIG.14.

It should be understood that the number of the working areas411is not limited by the disclosure, but may be adaptively modified into other numbers according to actual requirements.

For example, in an experiment that the automatic detection machine4is applied to DNA (deoxyribonucleic acid) purification, when a well plate is placed in one of the working areas411of the detection platform41, the detection platform41is rotated to move the well plate to below the multifunctional pipette42assembled with the heater module2, that is, the axis direction (X-axis direction) of the multifunctional pipette42assembled with the heater module2is perpendicular to this working area411. The heater module2is used to heat a sample in the well plate to a target temperature. The heater module2heats the sample to denature the double-stranded DNA so as to generate single-stranded DNA, and the single-stranded DNA obtained by purification is applied to subsequent experimental analysis. Besides, the heater module2is used to keep the sample in the well plate at a target temperature such that the sample remains at the target temperature for subsequent experiments.

When the well plate is placed in one of the working areas411of the detection platform41, the detection platform41is rotated to move the well plate to below the multifunctional pipette42assembled with the magnetic module3. When magnetic beads are added to the sample in the well plate and the magnetic beads adsorb the target DNA, the magnetic module3provides magnetic force to attract the magnetic beads with the target DNA, which facilitates the retention of the target DNA in the purification step. Besides, while the magnetic module3provides magnetic force to attract the magnetic beads with the target DNA, the moving mechanism43drives the multifunctional pipette42assembled with the magnetic module3to another working area411, so that the magnetic beads with the target DNA attracted by the magnetic module3are moved to the another working area411.

When the well plate is placed in one of the working areas411of the detection platform41, the detection platform41is rotated to move the working area411to below the multifunctional pipette42assembled with the magnetic module3. The magnetic module3provides magnetic force to vibrate or stir the sample and an analytical solution in the well plate, so that the sample and the analytical solution are shaken and mixed.

In an embodiment, in an optimization evaluation of the overall machine volume, compared with the traditional machine having a volume of 86×75×60 cm3, in the automatic detection machine4of the foregoing embodiment, the heater module2and the magnetic module3are removably assembled to the pipette module1according to needs, so that the volume of the automatic detection machine4is reduced to 73×75×50 cm3. In other words, compared with the volume of the traditional machine, the volume of the automatic detection machine4of the foregoing embodiment is reduced by 29% of the machine volume.

In some embodiments, the multifunctional pipette42may be a manual type. Referring toFIG.15, the pipette shell11is coupled with a holding part6on a side opposite to the pipette heads13. The user can hold the holding part6with a hand, control the pistons of the pistons assemblies12to operate and control the driving of the heater module2(and the magnetic module3), so that the user can hold the machine from the outside and use the multifunctional pipette42.

The third application state will be described here. The pipette heads13of the pipette module1are removably assembled with micropipette tips5of various sizes, as shown inFIG.16. When the pipette heads13are sleeved with the micropipette tips5, the operation of the pistons of the piston assemblies12can draw up liquid outside the micropipette tips5into the micropipette tips5, or dispense the liquid inside the micropipette tips5out of the micropipette tips5. As understood by those of ordinary skill in the art to which the present disclosure belongs, the micropipette tips5are commercially available. In detail, when liquid transfer is needed, the linkage element16can simultaneously pull the piston rods123of all the piston assemblies12out of the air channels122, so that the multifunctional pipette42can draw the liquid up into the micropipette tips5mounted thereon; or the linkage element16can simultaneously push the piston rods123of all the piston assemblies12into the air channels122, so that the multifunctional pipette42can dispense the liquid out of the micropipette tips5mounted thereon.

Based on the above, according to some embodiments, the multifunctional pipette42can heat the specimen by being assembled with the heater module2, or provide magnetic force or shake or stir the specimen by being assembled with the magnetic module3. According to some embodiments, the multifunctional pipette42can be applied in an automatic detection machine4, and can be driven by the moving mechanism43to perform automatic assembly and replacement so as to realize multiple functions of the multifunctional pipette42, which can facilitate automatic operation.