Pharmaceutical composition for treating aids

A pharmaceutical composition for treatment of AIDS comprising (1) herb medicines having anti-inflammatory anti-fever, expectorant or anti-tussive action, (2) herb medicines having nourishment, tonic, gastrointestinal tract function-improving or digestive action, and (3) herb medicines having anti-fungal or anti-viral action.

BACKGROUND OF THE INVENTION 
1. Field of the Invention 
The present invention provides a pharmaceutical composition for treating 
acquired immune deficiency syndrome (AIDS). 
2. Related Art 
Ever since AIDS was first reported in the U.S. in 1981, the number of 
persons afflicted with this disease has risen rapidly, with recent reports 
indicating that the number has grown to 300,000 with an additional 1.2 
million carriers in the U.S. alone. At present, although the virus has 
been identified and aggressive efforts are being made to develop effective 
methods of treatment and prevention of AIDS throughout the world, a 
suitable means of treatment and prevention has yet to be discovered as of 
1993. Moreover, the spread of this disease is much faster than what was 
originally expected, with current estimates indicating that the number of 
persons suffering from this disease will reach more than 40 million on a 
global scale at the end of this century. Thus, development of a means of 
prevention and discovery of an effective treatment method are being hoped 
for as quickly as possible. Although the development of a vaccine would be 
the most desirable, there are currently no vaccines being developed 
considered to be effective, and the time schedule for their completion 
remains undetermined. Moreover, the number of therapeutic drugs, such as 
AZT (amidothymidine) and DDT, are extremely few, the completion of an 
effective therapeutic drug appears to be a long way off, and there are 
serious adverse side effects, including bone marrow function disorders and 
liver function disorders, that make adequate continuous therapy 
essentially impossible. DDI (dideoxyinosine) and DDC (dideoxycytidine) and 
other drugs that have recently come into widespread use have effects 
similar to those of AZT, and there are have been no reports of these drugs 
resulting in successful treatment anywhere in the world thus far. 
Moreover, since patients are dying within only several years after onset 
of the disease and the mortality rate is 100%, AIDS is considered to be 
one of the most threatening diseases to face mankind in recorded history. 
The disease mechanism of AIDS first begins with invasion of viruses to 
CD.sub.4 lymphocytes, which serve as the basis of the immune system, the 
basic defense mechanism of the human body. These lymphocytes are 
successively destroyed resulting in acquired immunodeficiency. Ultimately, 
the disease invariably results in death caused by serious infection, 
malignant tumors such as Kaposi's sarcoma, and direct damage of the 
nervous system by the virus. The stages from infection to death can be 
broadly divided into the following three stages. 
(1) An asymptomatic stage extending from the time after infection to the 
manifestation of some form of subjective or objective symptoms, namely the 
HIV carrier stage; 
(2) A stage in which various symptoms are presented including infections 
resulting from lowered immunity, namely the ARC (AIDS related complex) 
stage; and, 
(3) The final stage that leads to death after passing through a stage 
involving various serious symptoms occurring based on the reduction of 
CD.sub.4 lymphocytes, such as Karini's pneumonia and including the 
characteristic opportunistic infections associated with AIDS. 
Therefore, in addition to early treatment of the opportunistic infections, 
treatment currently being considered attempts to take steps regress from 
stage (3) to stage (2), from stage (2) to stage (1) and if possible, to 
maintain the patient at stage (1) or (2) for an extended period of time 
once onset of the disease has begun. 
SUMMARY OF THE INVENTION 
The object of the present invention is to provide a pharmaceutical 
composition for the treatment of AIDS that is effective against AIDS and 
has hardly any adverse side effects. 
In order to achieve the objective described above, the present invention 
provides a pharmaceutical composition comprising herb medicines of the 
group: 
(1) at least a herb medicine having an anti-inflammatory, anti-fever, 
expectorant or anti-tussive action, selected from the group consisting of 
Melia azedarach L., Angepica dahurica B & H., Dendrobium hancockii R., 
Impatiens balsamina L., Citrus medica L., Loranthus parasiticus Merr., 
seeds of Celosia argentea L., roots of Cynanchum glaucescens (Decne) Hand. 
Mazz., and Glehnia littoralis Fr; 
(2) at least a herb medicine having a nourishment, tonic, good for 
gastrointestinal tract, or digestive action, selected from the group 
consisting of Prunus amygdalus Batsch., Dioscorea batatas Decne., 
Dendrobium hancockii R., Loranthus parasiticus Merr., Paullinia cupana 
Kunth, Acer saccarum Marsh., Citrus medica L., and Glycyrrhiza glabra L.; 
and 
(3) at least a herb medicine having an anti-fungal or anti-viral action, 
selected from the group consisting of Glehnia littoralis Fr., Angepica 
dahurica B & H, Loranthus parasiticus Merr., Impatiens balsamina L., and 
Gloiopeltis tenax T.A.

DETAILED DESCRIPTION OF THE INVENTION 
The inventors of the present invention first considered the concepts 
described below. (1) Substances should be used for the raw material that 
are found in nature, and particularly in plants (herb medicine), either 
have no or little toxicity, and are essentially free of adverse side 
effects on the human body. In addition, it is preferable that the 
substances also have tonic action if possible. (2) Substances should be 
used that inhibit the activity of HIV virus as much as possible. In 
addition, herb medicines having anti-biotic action as well as anti-viral 
action against as broad a spectrum of microbes as possible should be used 
to prevent the occurrence of infections in AIDS patients as much as 
possible. (3) Herb medicines should be used that have immunity enhancing 
action in order to supplement the weakened immunity of AIDS patients. In 
addition, substances should be used that have the function of an internal 
cytokine inducer such as interferon that acts on immune activity. (4) Herb 
medicines should be used that has action which increase the production of 
CD.sub.4 lymphocytes selectively destroyed by the AIDS virus, namely an 
herb medicine that has the action of increasing the CD.sub.4 /CD.sub.8 
ratio. (5) AIDS patients typically suffer from decreased gastrointestinal 
function, and particularly chronic diarrhea, absorption of nutrients is 
remarkably impaired, and as a result, tend to become malnourished 
resulting in promotion of progress of the disease. It is therefore 
desirable that herb medicines be used that also have action that maintains 
the stomach in a healthy state, are good for the gastrointestinal tract 
and prevent diarrhea. In addition, herb medicines should be used that are 
able to accommodate other symptoms that are manifested at a high rate, 
including febricula, lymphoma, bronchitis and pneumonia. 
However, in the case of treatment using various herb medicines, wherein 
each herb medicine contains, numerous types of active ingredients, new 
combinations must be created in which synergistic effects and conflicting 
effects of the respective effective actions of the herb medicines as well 
as new effects are demonstrated resulting from combining several types of 
herb medicines and blending in different amounts. However, although 
practitioners of oriental medicine (herbal medicine) in China, Japan and 
so forth are implementing treatment on a trial basis throughout the world, 
existing combinations have to be discovered that have any noteworthy 
effects. Although Shosaikoto has been reported to be effective in vitro, 
definite efficacy in human beings has yet to be reported. Thus, it is 
necessary to not confine studies to use of the present knowledge of 
oriental medicine, but rather seek out a herb medicine found throughout 
nature that is not routinely used, based on the introduction of a 
completely new concept. 
A pharmaceutical of oriental medicine along the herb medicines that compose 
it are determined according to diagnosis using oriental medicine (herbal 
medicine) techniques. This diagnosis is unique to oriental medicine, and 
differs from that found in western medicine and other means of natural 
therapy. The composition is determined according to the disease state of 
the individual, can certainly not be determined according to the name of 
the illness. 
However, since the AIDS treatment developed by the inventors of the present 
invention is to be effectively used throughout the world, including the 
U.S. and Europe where oriental medicine has not fully progressed, a 
composition must be applicable to nearly all AIDS patients. 
Based on the manner of thinking described above, the inventors of the 
present invention minutely searched through a total of 1500 types of 
oriental drugs used in oriental medicine, including roughly 600 types of 
non-routine new herb medicines, as well as roughly 1500 types of herb 
medicines used in traditional medicine in South America, Europe, India, 
Indonesia and Africa based on their experience in the field of oriental 
medicine, over the past roughly 8 years starting several years after AIDS 
was reported. A new composition was recently discovered that consists 
entirely of a herb medicine, has hardly any adverse side effects and can 
be taken easily. This new composition was actually used in 110 cases over 
the course of two years. As a result, this new composition was confirmed 
to have excellent efficacy making it remarkably beneficial as a treatment 
for AIDS, thus leading to completion of the present invention. 
In the preparing of a composition effective against AIDS, it is necessary 
to select ingredients from those having effects shown below in 
consideration of the AIDS disease state, its causes and various related 
conditions. Namely, those effects considered to be required can be divided 
into three types of actions consisting of: (1) anti-inflammatory, 
anti-fever, expectorant or anti-tussive action, (2) nourishment, tonic, 
good for the gastrointestinal tract or digestive action, and (3) 
anti-fungal or anti-viral action. 
The following factors must be taken into consideration in the selection of 
herb medicines having these actions. 
(a) Composition is typically blended based on a proportion of several types 
of herb medicines. These compositions demonstrate clinical effectiveness 
in the form of the total effectiveness of the particular ingredients. 
Namely, rather than the total sum of each of the effects of each herb 
medicine, these compositions are used by taking advantage of the 
synergistic and conflicting actions of each herb medicine used. Thus, 
instead of selecting herb medicines for the individual actions that are 
demonstrated by each, they must be selected while taking into 
consideration the overall blend of the herb medicine that respectively 
demonstrates the three types of actions listed above. 
(b) Since AIDS is a disease unlike any disease that has appeared in the 
history of mankind, it cannot be said to be completely handled even with 
Chinese medicine (oriental medicine) based on experience accumulated over 
the course of 3000 years. Thus, in addition to the herb medicines that 
have been described thus far, a wide range of herb medicine ingredients 
must also be sought out, such as folk medicines and the numerous plants 
found in the wild. 
(c) Herb medicine ingredients must not exhibit toxicity to the human body. 
In addition, these ingredients must be selected so that they can be taken 
easily by patients having debilitated physical strength and appetites by 
giving consideration to the taste and aroma when taking the medicine. 
(d) Although AIDS is an infectious disease, it progresses in chronic 
fashion in the same manner as tuberculosis. Thus, it is desirable to 
select herb medicine ingredients that are,suitable for taking for an 
extended period of time, namely those that do not have toxicity or adverse 
side effects when used in the past in a large number of cases over a long 
period of time. 
(e) Since the disease is frequently complicated with gastrointestinal 
disorders and anorexia in the majority of patients, it is preferable that 
only a small number of types of herb medicine ingredients be required to 
be taken, and moreover, that they only be required to be taken in small 
amounts. This is also preferable in economic terms as well. Thus, it is 
more preferable that a single herb medicine have not only 
anti-inflammatory and anti-fever action, but also the effective actions 
described above. 
Based on the above viewpoints, the following herb medicines were selected 
having the actions indicated below. 
(1) Anti-inflammatory, Anti-fever, Expectorant and Anti-tussive Action 
Melia azedarach L., Angerica dahurica B & H., Dendrobium hancockii R., 
Impatiens balsamina L., Citrus medica L., Loranthus parasiticus Merr., 
seeds of Gelosia angentea L., roots of Cynanchum glaucescens (Decne.) 
Hand. Mazz., and Glehnia littoralis Fr. 
(2) Nourishment, Tonic, Gastrointestinal Tract Function Improving, 
Digestive Action 
Prunus amygdalus Batsch., Dioscorea batatas Decne., Dendrobium hancockii 
R., Loranthus parasiticus Merr., Paullinia cupana Kunth, Acer saccarum 
Marsh., Citrus medica L., and Glycyrrhiza glabra L. 
(3) Anti-fungal and Anti-viral Action 
Glehnia littoralis Fr., Angerica dahurica B & H, Loranthus parasiticus 
Merr., Impatiens balsamina L., and Gloiopeltis tenax T.A. 
A weight ratio of herb medicins representing the groups (1) to (3) is 
preferably the group (1) 9.about.3: group (2) 9.about.3: group (3) 
6.about.1. In another embodiment, a weight ratio of herbmedicins 
representing the groups (1) to (3) is preferably the group (1) 3: group 
(2) 1.about.3: group (3) 0.5.about.2. 
Each of the above-mentioned herb medicines contain the following components 
and demonstrate the following actions. 
Melia azedarach L. 
Components: tannin, toosendanin etc. 
Actions: anti-parasitic effect, anti-inflammatory effect 
Angepica dahurica B & H 
Components: angellicin, angelicol etc. 
Actions: anti-biotic effect, pain killer effect, anti-viral effect, 
detoxication 
Denclrobium hancockii R. 
Component: dendrobine etc. 
Actions: tonic effect (especially for lung disease), anti-fever effect, 
pain killer effect, good for gastrointestinal tract, anti-inflmmnatory 
effect 
Impatiens balsamina L. 
Components: kaempferol, quercetin, etc. 
Actions: anti-inflammatory action, anti-biotic and anti-viral actions, 
detoxication, anti-tumor effect 
Citrus medica L. 
Components: hesperidin, essential oil etc. 
Actions: good for gastrointestinal tract, anti-tussive and sputum 
expectorant effect etc. 
Loranthus parasiticus Merr. 
Components: avicularin, quercetin 
Actions: heart stimulant effect, anti-biotic effect, anti-viral effect, 
diuretic effect 
Seeds of Celosia angentea L. 
Components: fatty oil 
Actions: anti-biotic effect, anti-hypertension effect 
Roots of Cynanchum glaucescens (Decne.) Hand. Mazz. 
Component: saponin 
Actions: anti-tussive and sputum broncho-ectasic action 
Glehnia littoralis Fr. 
Components: saponin, inulin 
Actions: anti-fungal effect, tonic effect, anti-tussive and sputum 
expectorant effect 
Prunus amygdalus Batsch 
Components: amygdarin, emulsin, vitamins 
Actions: anti-tussive and sputum expectorant action, lenitive action 
Dioscorea batatas Decne. 
Components: saponin, arginin, amylase 
Actions: digestive effect, tonic effect, anti-DM effect, nourishment 
Paullinia cupana Kunth 
Components: caffeine, saponin 
Actions: tonic effect, anti-diarrhea effect, anti-headache effect 
Acer saccarum Marsh, 
Component: glucose 
Action: sweetening effect 
Glycyrrhiza glabra L. 
Component: glycyrrhizin 
Actions: anti-inflammatory effect, steroid hormone-like effect, 
anti-allergic effect, anti-gastric ulcer effect, detoxication effect 
Gloiopeltis tenax T.A. 
Actions: anti-vital effect (influenza virus), malaise resolving effect 
The pharmaceutical composition of the present invention is blended by 
selecting at least one type of herb medicine from the groups of herb 
medicines having each of the actions described above. However, in the case 
a single herb medicine belongs to two or more groups, when a certain herb 
medicine is selected from one group, another herb medicine must be 
selected from another group. Thus, the pharmaceutical composition of the 
present invention must always contain at least 3 more types of herb 
medicines. 
In the present invention, the types of herb medicines used and their 
blending ratios are determined according to the condition of the AIDS 
patient. For example, in winter, a composition is preferable that contains 
mainly (1) a herb medicine having anti-inflammatory, anti-fever, 
expectorant and anti-tussive action, and (2) a herb medicine that has 
anti-viral action for influenza, cold and following bronchitis and 
pneumonia that occur easily in AIDS patients. This type of composition 
preferably contains Angerica dahurica B & H, Dendrobium hancockii R., 
roots of Cynanchum glaucescens (Decne) Hand Mazz., Dioscorea batatas 
Decne., Melia azedarach L., Loranthus parasiticus Merr., Glycyrrhiza 
glabra L., Acer saccarum Marsh and Gloiopeltis tenax T.A. The preferable 
ratios of this composition are 3 parts by weight of Dioscorea batatas 
Decne. and Melia azedarach L., 2 parts by weight of Loranthus parasiticus 
Merr., Angepica dahurica B & H and Dendrobium hancockii R., and 1 part by 
weight of Glycyrrhiza glabra L., Gloiopeltis tenax T.A., Acer saccarum 
Marsh. and roots of Cynanchum glaucescens (Decne.) Hand. Mazz. 
Alternatively, composition preferably comprises Prunus amygdalus Batsch., 
Celosia argentea L., roots of Loranthus parasiticus Merr., Dioscorea 
batatas Decne., Melia azedarach L., Loranthus parasiticus Merr., 
Glycyrrhiza glabra L., Acer saccarum Marsh., Citrus medica L. and 
Paullinia cupana Kunth. 
Preferable ratio of these components is 3 parts by weight of Dioscorea 
batatas Decne., 3 parts by weight of Melia azedarach L., 2 parts by weight 
of Loranthus parasiticus Merr., 2 parts by weight of Prunus amygdalus 
Batsh., 2 parts by weight of Celosia argentea L, 1 part by weight of 
Glycyrrhiza glabra L., 1 part by weight of Citrus medica L., 1 part by 
weight of Acer saccarum Marsh., and 1 part by weight of Paullinia cupana 
Kunth. 
In addition, in the case AIDS patients are complicated with fungal 
diseases, it is necessary to use Glehnia littoralis Fr. in a herb medicine 
having anti-fungal and anti-viral action. For example, Dioscorea batatas 
Decne., Melia azedarach L., Angerica dahurica B & H, Loranthus parasiticus 
Merr., roots of Cynanchum glaucescens (Decne.) Hand. Mazz., Glycyrrhiza 
glabra L., Glehnia littoralis Fr., Citrus medica L., and Acer saccarum 
Marsh are used, and their ratios are preferably 3 parts by weight of 
Dioscorea batatas Decne. and Melia azedarach L., 2 parts by weight of 
Angerica dahurica B & H, Loranthus parasiticus Morr. and roots of 
Cynanchum glaucescens (Decne.) Hand Mazz., and 1 part by weight of 
Glycyrrhiza glabra L., Glehnia littoralis Fr., Citrus medica L., and Acer 
saccarum Marsh. 
Moreover, in the case AIDS patients have symptoms of gastroenteritis or 
chronic diarrhea, a composition is preferable that primarily contains a 
herb medicine that is good for the gastrointestinal tract and has 
digestive action. This type of composition contains, for example, 
Dioscorea batatas Decne., Melia azedarach L., Dendrobium hancockii R., 
Loranthus parasiticus Merr., Angerica dahurica B & H, Glycyrrhiza glabra 
L., Citrus medica L., Cynanchum glaucescens (Decne.) Hand. Mazz. (or 
Paullinia cupana Kunth), and Acer saccarum Marsh. The ratios of these are, 
for example, 3 parts by weight of Dioscorea batatas Decne. and Melia 
azedarach L., 2 parts by weight of Dendrobium hancockii R., Loranthus 
parasiticus Merr. and Angerica dahurica B & H, and 1 part by weight of 
Glycyrrhiza glabra L., Citrus medica L., Cynanchum glaucescens (Decne.) 
Hand. Mazz. (or Paullinia cupana Kunth), and Acer saccarum Marsh. 
In the present invention, a composition containing at least Melia azedarach 
L., Dioscorea batatas Decne., Loranthus parasiticus Merr., Angerica 
dahurica B & H, Dendrobium hancockii R., Paullinia cupana Kunth, 
Glycyrrhiza glabra L. (or Acer saccarum Marsh.), and Gloiopeltis tonax 
T.A. (or Citrus medica L.) is typically preferable, and their ratios are, 
for example, 3-10 parts by weight of Melia azedarach L. and Dioscorea 
batatas Decne., 2-8 parts by weight of Loranthus parasiticus Merr., 
Angepica dahurica B & H and Dendrobium hancockii R., and 0.5-3 parts by 
weight of Paullinia cupana Kunth, Glycyrrhiza glubra L. (or Acer saccarum 
Marsh.) and Gloiopeltis tonax T.A. (or Citrus medica L.). 
Normally, herb medicines are effective when taken either between meals or 
on an empty stomach. In special cases, such as cases when patients have 
gastrointestinal disorders or toxicity, they may be directed to be taken 
after meals. In the case of the pharmaceutical composition for treating 
AIDS of the present invention, herb medicines are selected in 
consideration of not causing gastrointestinal disorders. Moreover, since 
these herb medicines are believed to be completely free of toxicity, there 
have been no objective or subjective findings indicating toxicity observed 
based on actual experience. 
The pharmaceutical composition for treating AIDS of the present invention 
is normally administered orally. In this case of administration to normal 
adults, all of the component herb medicines are blended at their 
prescribed ratios at a proportion of 4-12 g of the maxim weight of the 
component herb medicines, the herb medicines are brewed for roughly 30-50 
minutes in a suitable amount (300-500 ml) of mineral water (natural 
water), the solution is brewed down to a total of roughly 200 ml, and then 
taken 2-3 times per day 20-30 minutes before meals. In the case of 
children, the amount is reduced corresponding to body weight. An amount 
equal to roughly 1/3 the amount for adults is suitable for children 
roughly 6 years old. In addition, when it is difficult to take the herb 
medicine due to its characteristic bitter taste, natural maple syrup and 
honey are allowed to be added as the best sweeteners. In addition, when 
administered in the form of an extract, a suitable amount of vehicle may 
be added to form granules or tablets, while the syrups or cookie-like 
compositions can be formed for administration to children. In addition, a 
powder of the raw herb medicine can be combined with maple syrup or honey 
to form into pills. 
On the other hand, in the case oral administration is impossible for 
whatever reason, the composition of the present invention can also be 
administered by injection, suppository (enema), inhalation and so forth. 
For example, the composition can be administered in the form of 
subcutaneous injection, intramuscular injection, intravenous drip or 
intravenous injection by preparing an injection solution of herb medicine 
as is performed in modern Chinese oriental medicine. In addition, a 
suitable amount can be injected into the rectum or inhaled through the use 
of a nebulizer. 
EXAMPLES 
The following provides a detailed explanation by Examples. However, the 
scope of the present invention is by no means limited by the following 
embodiment. 
Example 1 
The composition, dose and dosing method of the pharmaceutical composition 
for treating AIDS of the present invention used in this Example are as 
shown below. 
The body weights prior to treatment of 55 infant AIDS patients used in this 
Example were 7.7-14.3 kg (mean: 10.75 kg), for actual administration, the 
present composition, composed at the weight ratios of: 1.5 g of Melia 
azedarach L., 1.5 g of Dioscorea batatus Dence., 1.0 g of Prunus amygdalus 
Batsch., 1.0 g of Dendorobium hancockii R., 1.0 g of Loranthus parasiticus 
Merr., 0.5 g of Glycyrrhiza glabra L., 0.5 g of Citrus medica L., 0.5 g of 
Paullinia cupana Kunth. and 0.5 g of Acer saccarum. Marsh. with respect to 
a body weight of 10 kg, was placed in roughly 100 ml of mineral water, 
brewed down to 30 ml for roughly 40 minutes over a low flame, and 
administered orally twice a day (30 minutes before the morning and evening 
meals as a general rule). 
The 55 patients were divided to 5 groups the test groups were as follow: 
The 55 patients were divided to 5 groups the test groups were as follow: 
Group I: the present composition (9 patients) 
Group II: the present composition+astol+soup (22 patients) 
Group III: the present composition+astol+soup+AZT 6 mg/kg/day (8 patients) 
Group IV: AZT (8 patients) 
Group V: untreated control group (8 patients) 
CD.sub.4 cell count and CD.sub.4 /CD.sub.8 rate were measured four times 
(before treatment,five months, seven months and a year after treatment). 
As seen from FIG. 1, CD.sub.4 cell count of Groups I and II measured at 
significantly higher than the other groups. Groups III, and IV (treated 
with only AZT) and V (control) measured much lower, while supprisingly, 
Group IV had the lowest CD.sub.4 cell count. So, the present composition 
maintains the CD.sub.4 of pediatric AIDS patients at a high level. We must 
consider the possibility that AZT has a side effect of depressing the 
lymphatic system in the human body, despite its direct effect on the HIV 
virus. 
The clinical results were measured six months after treatment. 
To decide the clinical effect the following clinical symptoms were 
observed: 
Fever 
Cough and sputum (chronic) 
Lymphadenopathy 
Weight loss 
Chronic diarrhea 
Appetite 
Nausea (with vomiting) 
Malaise (fatigue) 
Night sweating 
Skin disease 
Stomatitis 
Hepatomegally 
Spenomegally 
Neurological disorder 
Each symptom was given +1 score if it became worse, and the definition of 
clinical condition were as follows: 
Excellent: -4 - - - 
Good: -2 - - - -3 
Same (unchanged): +1 - - - -1 
Worse: +2 - - - 
As seen from FIG. 2, the improvement is seen in Groups I, II and III, 
especially in Group I and II. 
The clinical results (A) obtained from Groups I, II and III using the 
present composition and the clinical results (B) obtained from Groups IV 
and V not using the present composition are compared in FIG. 3. FIG. 3 
clearly shows the clinical differences between the groups treated with the 
herbs and those not treated. 
Example 2 
The experiment as described in Example 1 was compared with other 211 
patients. Among 31 patients treated with the present composition, one 
patient died in one year (notality 3.1%) , while among 211 patients 
treated with conventional method not using the present composition, 48 
patients died in one year (notality 22.7%), as shown in FIG. 4. 
The present inventor have already treated about 110 pediatric AIDS patients 
and a few adults at two hospitals for 18 months. 
Through these procedures, the patients did not experience any side effects 
or toxic symptoms, and almost all patients who have been treated with the 
present composition became much better clinically, and began to grow again 
both physically as well as mentally. Clinical recovery of adults was 
similar to the children, even in the few cases we observed. 
The Advantages of this treatment: 
a. The present medicine is made of only natural materials, consequently it 
has no toxins and no side effects at all as compared with chemical 
medicines. 
b. This treatment is gentle enough for weak patients who have suffered from 
the HIV virus for a long time. It can also be used to treat patients of 
all ages and stages of illness. 
c. This treatment keeps the CD.sub.4 count level high, and therefore, 
protects the patient from the many secondary diseases or symptoms which 
accompany the HIV infection. 
d. This treatment can be used with all other methods including chemical 
medicine (AZT, DDI, etc.), if the doctor or patient desires. 
e. This treatment reduced the morality rate from 22.7% to 3.1%. 211 cases 
were treated without using the present composition, of which 48 cases were 
fatal. On the contrary, 31 cases were treated with the present composition 
and only one case died. 
It is clear that this new treatment can prolong the patient's life safely 
and remarkably, also can prevent the complications caused by HIV 
infection, as it is well known that HIV virus does not kill human beings 
by itself. 
In conclusion, the present invention has demonstrated that the present 
natural herbal treatment has a profound effect on the CD.sub.4 count and 
consequently prolongs the life of the HIV positive patient.