COSMETIC METHOD FOR CHANGING THE APPEARANCE OF EYES

The current application is directed to cosmetic methods for changing the appearance of eyes by causing a retraction of the eyelids so that the eyes appear to be more open and have a wider appearance. Various methods involve application of one or more prostaglandins, synthetic prostaglandins, including synthetic prostaglandin F, and synthetic prostaglandin analogues, to eyelids, which results in contraction of eyelid muscles and a wider, more open appearance of the eyes.

DETAILED DESCRIPTION

Many medications are currently used to treat glaucoma and ocular hypertension. These include: (1) Travatn®, which contains travoprost, propan-2-yl 7-[3,5-dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-but-1-enyl]-cyclopentyl]hept-5-enoate, a synthetic prostaglandin F analogue, the structural formula for which is shown inFIG. 1; (2) Cosopt®, which includes dorzolamide hydrochloride,(4S,6S)-2-ethylamino-4-methyl-5,5-dioxo-5λ6,7dithiabicyclo[4.3.0] nona-8,10 -diene-8-sulfonamide, the structural formula for which is shown inFIG. 2; (3) timolol maleate, (S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol, the structural formula for which is shown inFIG. 3; (4) Rescula®, which includes unoprostone isopropyl, isopropyl (Z)-7-[(1R,2R,3R,5 S)-3,5-dihydroxy-2-(3-oxodecyl)cyclopentyl] hept-5-enoic acid, the structural formula for which is shown inFIG. 4; (5) Xalatan®, which contains latanoprost, isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)3-hydroxy-5-phenylpentyl]-cyclopentyl] hept-5-enoate. the structural formula for which is shown inFIGS. 5; and (6) Lumigan®, which contains bimatoprost, 7-[3,5-dihydroxy-2-(3 -hydroxy-5-phenyl-pent-1-enyl)-cyclopentyl]-N-ethyl-hept-5-enamide, the structural formula for which is shown inFIG. 6. These compounds are normally suspended or dissolved in sterile, isotonic, buffered aqueous solutions for use as eye drops, and effect lowering of the internal pressure within the eye, or intraocular pressure.

Recently, the current inventor has discovered that travoprost, dorzolamide hydrochloride, timolol maleate, unoprostone, latanoprost, and bimatoprost can be topically applied, alone or in combination, to the eyelids in order to cause the eyelids to retract more completely, thus ameliorating ptosis and/or improving facial appearance. Topical treatments to which the current application is directed include ointments, creams, and solutions that contain one or more of the compounds travoprost, dorzolamide hydrochloride, and timolol maleate, alone or in combination, and/or one or more chemically-related compounds and may also include pure forms of various types of prostaglandin, synthetic prostaglandin, and synthetic prostaglandin analogues. These ointments and solutions are topically applied to eyelids in order to treat ptosis and/or to improve facial appearance. The ointments and solution may include, in addition to the above-mentioned active ingredients, stabilizers, buffering compounds, salts, carriers, viscosity enhancers, colorants, emollients, emulsifiers, bactericidal and germicidal agents, preservatives, and other ingredients that improve shelf life, application, consistency, and compatibility with topical application, among other things.

It turns out, as has been revealed by various experiments and trials, that application of pure or concentrated solutions of prostaglandin, synthetic prostaglandin, or synthetic prostaglandin analogues to eyelid tissue and/or surrounding tissues is effective in raising eyelids to give a more open, wider appearance to the eyes of a patient or user. Either pure prostaglandin, synthetic prostaglandin, or synthetic prostaglandin analogues may be rubbed into the eyelid tissues or a relatively concentrated solution of prostaglandin in any of various organic solvents, including ethanol, or ethanol-water mixtures, can be applied to produce the effect. Prostaglandin, synthetic prostaglandin, or synthetic prostaglandin analogs may be additionally included in various eye shadows and other cosmetic products that are routinely applied to eyelids in order to produce the eye-widening cosmetic effect, as well as in many different mixtures, suspensions, solutions, powders, ointments, creams, and other substances.

Any of a variety of different frequencies of application, total amount of prostaglandin topically applied during each application, and other such parameters of a cosmetic application schedule may be varied in accordance with the extent of the eye-widening effect desired, individual patients, and other such considerations. These considerations may, for example, include other types of cosmetics, treatment substances, and products routinely used by a patient, the overall condition of a patient's skin, the age of the patient, and other such considerations.

The methods to which the current application are directed include application of prostaglandin, synthetic prostaglandin, or synthetic prostaglandin analogues to eyelid tissue by finger, by any of various types of mechanical applicators, by spray application from a spray applicator, nebulizer, or atomizer, by dusting application, and by applying patches, eye masks, or other materials to the eyelids that are coated or infused with one or more prostaglandin, synthetic prostaglandin, or synthetic prostaglandin analogues.