Optical tomography system

Light emitted from the light source unit is divided into measuring light and reference light. An optical path length of the measuring light or the reference light which has been divided by the light dividing means is adjusted. Interference light of the reflected light and the reference light is detected and a tomographic image of the object is obtained on the basis of the detected interference light. The optical path length is adjusted by a reflecting mirror which reflects the measuring light or the reference light radiated from the optical fiber, a first lens which is disposed between the reflecting mirror and the optical fiber and a second lens which collects the measuring light or the reference light made parallel by the first lens on the reflecting mirror and makes parallel the measuring light or the reference light reflected by the reflecting mirror.

BACKGROUND OF THE INVENTION

1. Field of the Invention

This invention relates to an optical tomography system for obtaining an optical tomographic image by measurement of OCT (optical coherence tomography).

2. Description of the Related Art

As a method of obtaining a tomographic image of an object of measurement such as living tissue, there has been proposed, in addition to an ultrasonic tomography system, a method where OCT (optical coherence tomography) is measured as disclosed in Japanese Unexamined Patent Publication Nos. 6(1994)-165784 and 2003-139688. In the OCT measurement, a phenomenon that interference light is detected when the optical paths of the measuring light and the reflected light conform to the optical path of the reference light in length is used. That is, in this method, low coherence light emitted from a light source is divided into measuring light and reference light and the measuring light is projected onto the object of measurement, while the reflected light from the object of measurement is led to a mixing means. The reference light is led to the mixing means after its optical path length is changed in order to change the depth of measurement in the object. By the mixing means, the reflected light and the reference light are superposed one on another, and interference light due to the superposition is detected by, for instance, heterodyne detection.

In the above OCT system, a tomographic image is obtained by sweeping the optical path length of the reference light, thereby changing the measuring position (the depth of measurement) in the object. This technique is generally referred to as “TD-OCT (time domain OCT)”. More specifically, in the optical path length changing mechanism for the reference light disclosed in Japanese Unexamined Patent Publication No. 6(1994)-165784, an optical system which collects the reference light emitted from the optical fiber on a mirror is provided and the optical path length is adjusted by moving only the mirror in the direction of the beam axis of the reference light. Further, in the optical path length changing mechanism for the reference light disclosed in Japanese Unexamined Patent Publication No. 2003-139688, the reference light emitted from the optical fiber is turned to parallel light by a parallel lens, and the reference light in the parallel light is collected and caused to enter the optical fiber again by an optical path length adjusting lens, and the optical path length adjusting lens is moved back and forth in the direction of the beam axis of the reference light to adjust the optical path length.

Whereas, as a system for rapidly obtaining a tomographic image without changing the optical path length of the reference light, there has been proposed an SS-OCT (swept source OCT) system where interference light is detected while the frequency of the light emitted from the light source is changed with time. In the SS-OCT system, an interferogram interference intensity signal is obtained without changing the optical path length by sweeping the frequency of the laser beam emitted from the light source to cause the reflected light and the reference light to interfere with each other by the use of a Michelson interferometer. Then a tomographic image is generated by carrying out a Fourier analysis on the interferogram signal in the region of an optical frequency.

Whereas, as a system for rapidly obtaining a tomographic image without sweeping the optical path length of the reference light, there has been proposed an optical tomography method of obtaining an optical tomographic image by measurement of SD-OCT (spectral domain OCT). In the SD-OCT system, a tomographic image is formed without scanning in the direction of depth, by dividing broad band, low coherence light into measuring light and reference light by the use of a Michelson interferometer, and carrying out a Fourier analysis on each channeled spectrum obtained by decomposing the interference light of the reflected light, which returns when projecting the measuring light onto the object, and the reference light into frequency components.

In the SD-OCT system and the SS-OCT system described above, it is still necessary to adjust the optical path difference within an interference distance within which the measuring light and the reference light can interfere with each other, that is, to adjust the optical path length of the reference light (or the measuring light) within a measurable range within which a tomographic image can be obtained. As a means for adjusting the optical path length, it is conceivable to employ the optical path length adjusting mechanism disclosed in Japanese Unexamined Patent Publication Nos. 6(1994)-165784 and 2003-139688.

However, when only a mirror or a lens is moved as in the optical path length adjusting mechanism disclosed in Japanese Unexamined Patent Publication No. 6(1994)-165784, there is involved a problem that a stable intensity of the reflected light cannot be obtained when the measuring position is scanned in the direction of depth since light radiated from the optical fiber cannot be collected on the mirror and reflected light from the mirror which enters the optical fiber is reduced in amount.

Further, when an optical path length adjusting lens is moved back and forth in the direction of the optical axis of the reference light in order to adjust the optical path length, the position of focus of the optical path length adjusting lens is also moved and there is involved a problem that a stable intensity of the interference light cannot be obtained when the measuring position is scanned in the direction of depth since reference light radiated from the optical path changing lens which enters the optical fiber is reduced in amount.

That is, when reference light propagating an optical fiber is taken out to be adjusted in its optical path length and is returned to the optical fiber, it is necessary to cause the light to enter the core of the optical fiber which is several μm to ten μm in its diameter. Accordingly, a stable intensity of the interference light cannot be obtained and the quality of the image can deteriorate when the measuring position is scanned in the direction of depth since the amount of reference light which enters the optical fiber when light is deviated from the core of the optical fiber or the beam diameter is increased upon adjustment of the optical path length disclosed in Japanese Unexamined Patent Publication Nos. 6(1994)-165784 and 2003-139688.

Also when the optical path length adjusting mechanisms disclosed in Japanese Unexamined Patent Publication Nos. 6(1994)-165784 and 2003-139688 are employed in the SS-OCT system and the SD-OCT system, there is a problem that the intensity of interference light is reduced upon adjustment of the optical path length and the quality of the image can deteriorate.

SUMMARY OF THE INVENTION

In view of the foregoing observations and description, the primary object of the present invention is to provide an optical tomography system which can prevent deterioration of the image quality due to reduction in the measuring light or the reference light when the optical path length adjustment is effected.

In accordance with the present invention, there is provided an optical tomography system for obtaining a tomographic image of an object to be measured comprising

a light source unit which emits light,

a light dividing means which divides light emitted from the light source unit into measuring light and reference light,

an optical path length adjusting means which adjusts an optical path length of the measuring light or the reference light which has been divided by the light dividing means,

an optical fiber which guides the measuring light or the reference light to the optical path length adjusting means,

a mixing means which mixes the reflected light from the object when the measuring light is projected onto the object and the reference light,

an interference light detecting means which detects interference light of the reflected light and the reference light which have been mixed by the mixing means, and

a tomographic image obtaining means which obtains a tomographic image of the object on the basis of the interference light detected by the interference light detecting means,wherein the improvement comprises that the optical path length adjusting means comprises

a reflecting mirror which reflects the measuring light or the reference light radiated from the optical fiber,

a first lens which is disposed between the reflecting mirror and the optical fiber to make parallel the measuring light or the reference light radiated from the core of the optical fiber and at the same time, to collect the measuring light or the reference light reflected by the reflecting mirror on the core of the optical fiber, and

a second lens which collects the measuring light or the reference light made parallel by the first lens on the reflecting mirror and at the same time, makes parallel the measuring light or the reference light reflected by the reflecting mirror.

The optical path length adjusting means may further comprise a base portion to which the second lens and the reflecting mirror are fixed and a movement means which moves the base portion in the direction of the optical axis of the first lens.

Further, the optical path length adjusting means may further comprise a wedge-like transparent member disposed between the first and second lenses and a movement means which moves the transparent member in a direction perpendicular to the direction of the optical axis of the first lens.

Further, the optical path length adjusting means may further comprise an electro-optic element which is disposed between the first and second lenses and whose refractive index changes by applying an electric field and a drive power source which applies an electric field to the electro-optic element. The optical path length adjusting means may be a combination of the elements described above.

The light source unit may emit a laser beam while sweeping the wavelength, while the image obtaining means obtains a tomographic image of the object by carrying out frequency-analysis on the interference light, and the optical path length adjusting means changes the optical path length of the measuring light or the reference light so that a tomographic image signal can be obtained.

Further, the light source unit may emit low coherence light, while the image obtaining means obtains a tomographic image of the object by carrying out frequency-analysis on the interference light, and the optical path length adjusting means changes the optical path length of the measuring light or the reference light so that a tomographic image signal can be obtained.

Further, the light source unit may emit low coherence light, and the optical path length adjusting means may sweep the optical path length of the measuring light or the reference light in order to change the position in the direction of depth to be measured.

In accordance with the optical tomography system of the present invention, since the optical path length adjusting means comprises a reflecting mirror which reflects the measuring light or the reference light radiated from the optical fiber, a first lens which is disposed between the reflecting mirror and the optical fiber to make parallel the measuring light or the reference light radiated from the core of the optical fiber and at the same time, to collect the measuring light or the reference light reflected by the reflecting mirror on the core of the optical fiber, and a second lens which collects the measuring light or the reference light made parallel by the first lens on the reflecting mirror and at the same time, makes parallel the measuring light or the reference light reflected by the reflecting mirror, the focusing point of the first lens relatively to the core of the optical fiber and the focusing point of the second lens relatively to the reflecting mirror are kept unchanged when the optical path length of the measuring light or the reference light is adjusted between the first and second lenses, a tomographic image can be obtained from the interference light based on the stabilized amount of reference light and deterioration of the image quality is prevented.

When the optical path length adjusting means further comprises a base portion to which the second lens and the reflecting mirror are fixed and a movement means which moves the base portion in the direction of the optical axis of the first lens, since the focusing point of the first lens relatively to the core of the optical fiber and the focusing point of the second lens relatively to the reflecting mirror are kept unchanged when the optical path length of the measuring light or the reference light is adjusted, a tomographic image can be obtained from the interference light based on the stabilized amount of reference light and deterioration of the image quality is prevented.

When the optical path length adjusting means further comprises a wedge-like transparent member disposed between the first and second lenses and a movement means which moves the wedge-like transparent member in a direction perpendicular to the direction of the optical axis of the first lens, since the focusing point of the first lens relatively to the core of the optical fiber and the focusing point of the second lens relatively to the reflecting mirror are kept unchanged when the optical path length of the measuring light or the reference light is adjusted, a tomographic image can be obtained from the interference light based on the stabilized amount of reference light and deterioration of the image quality is prevented.

When the optical path length adjusting means further comprises, an electro-optic element which is disposed between the first and second lenses and whose refractive index changes by applying an electric field and a drive power source which applies an electric field to the electro-optic element since the focusing point of the first lens relatively to the core of the optical fiber and the focusing point of the second lens relatively to the reflecting mirror are kept unchanged when the optical path length of the measuring light or the reference light is adjusted, a tomographic image can be obtained from the interference light based on the stabilized amount of reference light and deterioration of the image quality is prevented.

Further, when the light source unit emits a laser beam while sweeping the wavelength, while the image obtaining means obtains a tomographic image of the object by carrying out frequency-analysis on the interference light, and the optical path length adjusting means changes the optical path length of the measuring light or the reference light so that a tomographic image signal can be obtained, a tomographic-image can be obtained from the interference light based on the stabilized amount of reference light and deterioration of the image quality is prevented.

Further, when the light source unit emits low coherence light, while the image obtaining means obtains a tomographic image of the object by carrying out frequency-analysis on the interference light, and the optical path length adjusting means changes the optical path length of the measuring light or the reference light so that a tomographic image signal can be obtained, a tomographic image can be obtained from the interference light based on the stabilized amount of reference light and deterioration of the image quality is prevented.

Further, when the light source unit emits low coherence light while and the optical path length adjusting means sweeps the optical path length of the measuring light or the reference light in order to change the position in the direction of depth to be measured, a tomographic image can be obtained from the interference light based on the stabilized amount of reference light and deterioration of the image quality is prevented.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

Embodiments of the present invention will be described in detail with reference to the drawings, hereinbelow.FIG. 1is a schematic diagram that illustrates an optical tomography system in accordance with a first embodiment of the present invention. The optical tomography system1of this embodiment is for obtaining a tomographic image of an object of measurement such as a living tissue or a cell in a body cavity by measuring the SS-OCT. The optical tomography apparatus1of this embodiment comprises: a light source unit10for emitting a light beam L; a light dividing means3for dividing the light beam L emitted from the light source unit10into a measuring light beam L1and a reference light beam L2; an optical path length adjusting means20for adjusting the optical path length of the reference light beam L2divided by the light dividing means3; a probe30which guides to the object S to be measured the measuring light beam L1divided by the light dividing means3; a mixing means4for mixing a reflected light beam L3from the object S when the measuring light beam L1is irradiated onto the object S, and the reference light beam L2; and an interference light detecting means40for detecting interference light beam L4of the reflected light beam L3and the reference light beam L2which have been mixed.

The light source unit10emits the laser light beam L while sweeping the frequency at a constant period and comprises, for instance, a synchronized semiconductor laser. Specifically, the light source unit10comprises: a semiconductor optical amplifier11(semiconductor gain medium); and an optical fiber FB10and the optical fiber FB10is connected to both ends of the semiconductor optical amplifier11. The semiconductor optical amplifier11functions to emit weak release light into a first end of the optical fiber FB10, when a drive current is injected thereinto, and to amplify the light that enters it from a second end of the optical fiber FB10. When the drive current is supplied to the semiconductor optical amplifier11, a light beam L is emitted to an optical fiber FB1from a resonator formed by the semiconductor optical amplifier11and the optical fiber FB10.

Further, an optical divider12is linked to the optical fiber FB10, and a portion of the light beam that propagates within the optical fiber FB10is emitted into an optical fiber FB11. The light beam, which is emitted from the optical fiber FB11, passes through a collimating lens13, a diffraction grating14, and an optical system15, to be reflected by a rotating polygon mirror16. The light beam reflected by the rotating polygon mirror16passes through an optical system15, the diffraction grating14, and the collimating lens13, to reenter the optical fiber FB11.

The rotating polygon mirror16rotates in the direction indicated by arrow R1, to vary the angle of each reflective surface thereof with respect to the optical axis of the optical system15. Thereby, only a light beam having a specific frequency, from among the light spectrally split by the diffraction grating14, is returned to the optical fiber FB11. The frequency of the light beam that reenters the optical fiber FB11is determined by the angle formed by the optical axis of the optical system15and the reflective surface of the rotating polygon mirror16. The light beam of a specific frequency band that enters the optical fiber FB11is caused to enter the optical fiber FB10by the optical divider12. As a result, the laser light beam L of the specific frequency is emitted toward the optical fiber FB1. Accordingly, when the rotating polygon mirror16rotates in the direction indicated by arrow R1at a constant speed, the wavelength of the light beam which reenters the optical fiber FB11is swept at a period as shown inFIG. 2. That is, a laser beam L which is swept in its wavelength at a period is emitted toward the optical fiber FB1.

The light dividing means3comprises, for instance, a 2×2 fiber optic coupler and divides the light beam L led thereto by way of the optical fiber FB1from the light source unit10into the measuring light beam L1and the reference light beam L2. The light dividing means3is optically connected to two optical fibers FB2and FB3, and the measuring light beam L1is propagated through the optical fiber FB2while the reference light beam L2is propagated through the optical fiber FB3. InFIG. 1, the light dividing means3also functions as the mixing means4.

The probe30is optically connected to the optical fiber FB2and the measuring light beam L1is guided to the probe30from the optical fiber FB2. The probe30is inserted into a body cavity, for instance, through a forceps port by way of a forceps channel and is removably mounted on the optical fiber FB2by an optical connector OC.

The optical path length adjusting means20is disposed on the side of the optical fiber FB3radiating the reference light beam L2.FIG. 3is a schematic view showing an example of the optical path length adjusting means20and the optical path length adjusting means20will be described with reference toFIGS. 1 and 3. The optical path length adjusting means20changes the optical path length of the reference light beam L2in order to adjust a range over which a tomographic image is to be obtained and comprises a reflecting mirror22which reflects the reference light beam L2radiated from the optical fiber F3, a first lens21adisposed between the reflecting mirror22and the optical fiber FB3, and a second lens21bdisposed between the first lens21aand the reflecting mirror22.

The first lens21amakes parallel the reference light beam L2radiated from the core of the optical fiber FB3and at the same time, collects the reference light beam L2reflected by the reflecting mirror22on the core of the optical fiber FB3. The second lens21bcollects the reference light beam L2made parallel by the first lens21aon the reflecting mirror22and at the same time, makes parallel the reference light beam L2reflected by the reflecting mirror22. That is, the first and second lenses21aand21bform a confocal optical system.

Accordingly, the reference light beam L2radiated from the optical fiber FB3is turned to a parallel light by the first lens21aand is collected on the reflecting mirror22by the second lens21b. Subsequently, the reference light beam L2reflected by the reflecting mirror22is turned to a parallel light by the second lens21band is collected on the core of the optical fiber FB3by the first lens21a.

The optical path length adjusting means20is further provided with a base portion23to which the second lens21band the reflecting mirror22are fixed and a mirror movement means24which moves the base portion23in the direction of the optical axis of the first lens21a. In response to movement of the base portion23in the direction of arrow A, the optical path length of the reference light beam L2can be changed.

The mixing means4shown inFIG. 1comprises a 2×2 fiber optic coupler as described-above, and mixes the reference light beam L2which has been changed in its optical path length by the optical path length adjusting means20and the reflected light beam L3from the object S to emit the mixed light beam toward the interference light detecting means40by way of an optical fiber FB4.

The interference light detecting means40detects interference light L4of the reflected light beam L3and the reference light beam L2which have been mixed by the mixing means4. The image obtaining means50obtains a tomographic image of the object S by carrying out frequency analysis on the signal of interference light beam L4detected by the interference light detecting means40. The obtained tomographic images are displayed by the display system60. in the embodiment shown inFIG. 1, an optical detector40awhich detects the intensity of the laser light beam L branched from an fiber optic coupler2of the optical fiber FB1and an optical detector40bwhich detects the intensity of interference light beam L4are provided and the interference light detecting means40has a function of adjusting the balance of the intensity of the interference light beam L4on the basis of the output of the optical detector40a. This function suppresses unevenness in the light intensity by the frequency and permits to obtain a clearer image.

Here, detection of the interference light beam L4in the interference light detecting means40and image generation in the image obtaining means50will be described briefly. Note that a detailed description of these two points can be found in M. Takeda, “Optical Frequency Scanning Interference Microscopes”, Optical Engineering Contact, Vol. 41, No. 7, pp. 426-432, 2003.

When it is assumed that the light intensity of the interference fringes corresponding to each optical path length L when the reflected light beams L3from depths of the object S and the reference light beam L2interfere with each other with various optical path length differences is S(L), the light intensity I(k) detected in the interference light detecting means40is expressed by the following formula:

I⁡(k)=∫0∞⁢S⁡(L)⁡[L+cos⁡(kL)]⁢ⅆL(1)
wherein k represents the wave number and L represents the optical path length difference. Formula (1) may be considered to be given as an interferogram of a frequency range having a wave number of ω/c (k=ω/c). Accordingly, a tomographic image is obtained by obtaining information on the distance of the object S from the measurement initiating position and information on the intensity of reflection by carrying out frequency analysis by Fourier-transform on the spectral interference fringes detected by the interference light detecting means40and determining the intensity S(L) of the interference light L4.

Operation of the optical tomography system1having a structure described above will be described with reference toFIGS. 1 to 3, hereinbelow. When a tomographic image is to be obtained, the optical path length is first adjusted by moving the base portion23in the direction of the arrow A so that the object S is positioned in the measurable area. The light beam L is emitted from the light source unit10by sweeping the wavelength at a period and the light beam L is divided into the measuring light beam L1and the reference light beam L2by the dividing means3. The measuring light beam L1is led by the optical probe30into a body cavity and is projected onto the object S. Then the reflected light beam L3from the object S and the reference light beam L2reflected by the reflecting mirror22are mixed, and the interference light beam L4of the reflected light beam L3and the reference light beam L2is detected by the interference light detecting means40. A tomographic image is obtained by carrying out frequency analysis on a signal of the detected interference light beam L4in the image obtaining means50.

When the base portion23is moved in the direction of the arrow A in order to adjust the optical path length (FIG. 3), the focus of the first lens21ais never moved from the core of the optical fiber FB3. Further, the focus of the second lens21bis never moved from the reflecting mirror22. Accordingly, reduction of the amount of the reference light beam L2when the reference light beam reenters the optical fiber FB3after adjusted with its optical path length can be prevented, whereby deterioration of the image quality due to change of the intensity of the interference light beam L4every time the optical path length is adjusted can be prevented.

By forming a confocal optical system by the first and second lenses21aand21b, mounting errors may be increased when the second lens21band the reflecting mirror22are mounted on the base portion23, whereby the optical path length adjusting means manufacturing efficiency can be improved. That is, it is necessary for the optical path length adjusting means20to cause the light radiated from the core of the optical fiber FB3to reenter the core of the optical fiber FB3which is several μm to ten μm in its diameter. When, in the conventional optical path length adjusting means shown inFIG. 4A, having a collimator lens21aand a reflecting mirror22, the reflecting mirror22is fixed to the base portion23inclined to the optical axis CL by Δθ as shown inFIG. 4B, the amount of the reference light L2which enters the core of the optical fiber FB3is reduced. Accordingly, in the conventional optical path length adjusting means shown inFIG. 4A, the reflecting face of the reflecting mirror22must be strictly perpendicular to the optical axis CL of the collimator lens21a.

Whereas, in the optical path length adjusting means20where the first and second lenses21aand21bform a confocal optical system, even if the reflecting mirror22is fixed to the base portion23inclined to the optical axis CL by Δθ, the reference light beam L2reflected in the focusing position of the second lens21breturns to the focusing position of the first lens21a. Further, since the reference light beam L2is a laser beam, a beam waist BW having a depth of focus of ΔZ is formed in the focusing position of the second lens21bas shown inFIG. 6and so long as the reflecting face of the reflecting mirror22is in the beam waist BW, the reference light beam L2returns to the focusing position of the first lens21aeven if the reflecting mirror22is inclined by Δθ. Thus, the range of permissible mounting errors may be increased when the second lens21band the reflecting mirror22are mounted on the base portion23, whereby the optical path length adjusting means manufacturing efficiency can be improved.

FIG. 7is a schematic view showing the optical path length adjusting means in a tomography system of the present invention in accordance with a second embodiment. In the optical path length adjusting means120ofFIG. 7, parts analogous to those shown in the optical path length adjusting means20ofFIG. 3are given the same reference numerals and will not be described here.

The optical path length adjusting means120further comprises a wedge-like transparent member121disposed between the first and second lenses21aand21band a movement means122which moves the transparent member121in a direction perpendicular to the direction of the optical axis CL of the first lens21a. In response to movement of the transparent member121in the direction of arrow B by the movement means122, the optical path length of the reference light beam L2is adjusted. It is preferred that the transparent member121be even in number. Also, in this case, reduction of the amount of the reference light beam L2when the reference light beam L2reenters the optical fiber FB3after adjusted with its optical path length by the optical path length adjusting means120can be prevented, whereby deterioration of the image quality due to change of the intensity of the interference light beam L4every time the optical path length is adjusted can be prevented.

FIG. 8is a schematic view showing the optical path length adjusting means in a tomography system of the present invention in accordance with a third embodiment. In the optical path length adjusting means220ofFIG. 8, parts analogous to those shown in the optical path length adjusting means20ofFIG. 3are given the same reference numerals and will not be described here.

The optical path length adjusting means220ofFIG. 8further comprises an electro-optic element221which is disposed between the first and second lenses21aand21band whose refractive index changes by applying an electric field and a drive power source222which applies an electric field to the electro-optic element221. In response to application of an electric field to the electro-optic element221by the drive power source222, the refractive index of the electro-optic element221changes according to the intensity of the electric field, and the optical path length of the reference light beam L2is adjusted. Also, in this case, reduction of the amount of the reference light beam L2when the reference light beam L2reenters the optical fiber FB3after adjusted with its optical path length by the optical path length adjusting means220can be prevented, whereby deterioration of the image quality due to change of the intensity of the interference light beam L4every time the optical path length is adjusted can be prevented.

FIG. 9is a schematic view showing a tomography system of the present invention in accordance with another embodiment. The tomography system100will be described with reference toFIG. 9. In the tomography system100ofFIG. 9, parts analogous to those shown in the tomography system1ofFIG. 1are given the same reference numerals and will not be described here. The tomography system100ofFIG. 9differs from the tomography system1ofFIG. 1in the light source unit and the interference light detecting means. Specifically, the tomography system100is for obtaining a tomographic image of an object in a body cavity by measuring the SD-OCT and the light source unit110comprises a light source111emitting low coherence light such as an SLD (super luminescent diode) or an ASE (amplified spontaneous emission) and an optical system112which causes the light beam emitted from the light source111to enter an optical fiber FB1. Since the optical tomography system1of this embodiment is for obtaining a tomographic image with a part of a living tissue in a body cavity taken as the object S, it is preferred that the light source111be, for instance, a broad spectral band, ultra short pulse laser where attenuation of light due to scatter and/or absorption when transmitted through the object S is minimized.

The interference light detecting means140detects interference light L4of the reflected light beam L3and the reference light beam L2which have been mixed by the mixing means4, and comprises a spectral means142which divides the interference light beam L4having a plurality of wavelength bands by the wavelength bands and a light detecting means144which detects the amount of light of each wavelength band of the interference light beam L4divided by the spectral means142. The spectral means142comprises, for instance, a diffraction grating element, and divides the interference light beam L4entering it by way of the collimator lens141to output the divided interference light beam L4to the light detecting means144.

The light detecting means144is formed by a plurality of photo sensors which comprises a plurality of, for instance, one-dimensionally or two-dimensionally arranged CCDs and each of the photo sensors detects each wavelength band of the interference light beam L4entering by way of an optical system143. Information on the intensity of the reflected light beam of the positions in the direction of depth is obtained by carrying out frequency analysis in the image obtaining means50on a signal of the interference light beam L4detected in the interference light detecting means144, and an optical tomographic image can be generated.

Also, in the optical tomography system100ofFIG. 9, reduction of the amount of the reference light beam L2when the reference light beam L2reenters the optical fiber FB3after adjusted with its optical path length by the optical path length adjusting means20can be prevented, whereby deterioration of the image quality due to change of the intensity of the interference light beam L4every time the optical path length is adjusted can be prevented.

FIG. 10is a schematic view showing a tomography system of the present invention in accordance with still another embodiment. The tomography system200will be described with reference toFIG. 10. In the tomography system200ofFIG. 10, parts analogous to those shown in the tomography system1ofFIG. 1and the tomography system100ofFIG. 9are given the same reference numerals and will not be described here.

The tomography system200is for obtaining a tomographic image of an object in a body cavity by measuring the so-called TD-OCT and the optical path length adjusting means20has a function of changing the optical path length of the reference light beam L2, thereby changing the measuring position in the object S in the direction of depth. On the optical path of the reference light beam L2(the optical fiber FB3), a phase modulator210is disposed and the phase modulator210has a function of giving a slight frequency shift to the reference light beam L2. The reference light beam L2is guided to the optical fiber FB4by way of the mixing means4after adjusted with its optical path length and frequency-shifted by the optical path length adjusting means20.

The interference light detecting means220detects the interference light beam L4by, for instance, heterodyne detection. Specifically, when the whole optical path length which the measuring light beam L1travels back and forth from the dividing means3to the reflecting point in the object S is substantially equal to the whole optical path length which the reference light beam L2travels back and forth from the dividing means3and the reflecting mirror22, a beat signal which varies in intensity at the modulating frequency of the phase modulator210is generated. As the optical path length is changed by the optical path length adjusting means20, the measuring position (the depth of measurement) in the object S changes and the interference light detecting means220detects the beat signal in each measuring position. Information on the measuring positions is output to the image obtaining means from the optical path length adjusting means20. Then a tomographic image is generated on the basis of the beat signal detected by the interference light detecting means220and information on the moving distance from the mirror movement means24.

Also, in the optical tomography system200where TD-OCT is measured, reduction of the amount of the reference light beam L2when the reference light beam L2reenters the optical fiber FB3after adjusted with its optical path length by the optical path length adjusting means20can be prevented, whereby deterioration of the image quality due to change of the intensity of the interference light beam L4every time the optical path length is adjusted can be prevented.

In accordance with each embodiment described above, since the optical path length adjusting means comprises first and second lenses21aand21bforming a confocal optical system, the focusing point of the first lens21arelatively to the core of the optical fiber FB3and the focusing point of the second lens21brelatively to the reflecting mirror22are kept unchanged when the optical path length of the measuring light beam L1or the reference light beam L2is adjusted between the first and second lenses21aand21b, a tomographic image can be obtained from the interference light based on the stabilized amount of reference light L2and deterioration of the image quality can be prevented.

When the optical path length adjusting means120further comprises a wedge-like transparent member121disposed between the first and second lenses21aand21band a movement means122which moves the wedge-like transparent member121in a direction perpendicular to the direction of the optical axis of the first lens21aas shown inFIG. 7, since the focusing point of the first lens21arelatively to the core of the optical fiber and the focusing point of the second lens21brelatively to the reflecting mirror22are kept unchanged when the optical path length of the measuring light or the reference light is adjusted, a tomographic image can be obtained from the interference light based on the stabilized amount of reference light beam L2and deterioration of the image quality is prevented.

When the optical path length adjusting means220further comprises, an electro-optic element221which is disposed between the first and second lenses21aand21band whose refractive index changes by applying an electric field and a drive power source222which applies an electric field to the electro-optic element221as shown inFIG. 8, since the focusing point of the first lens21arelatively to the core of the optical fiber and the focusing point of the second lens21brelatively to the reflecting mirror are kept unchanged when the optical path length is adjusted, a tomographic image can be obtained from the interference light based on the stabilized amount of reference light L2and deterioration of the image quality is prevented.

When the optical path length adjusting means120further comprises, an electro-optic element221which is disposed between the first and second lenses21aand21band whose refractive index changes by applying an electric field and a drive power source222which applies an electric field to the electro-optic element221as shown inFIG. 8, since the focusing point of the first lens21arelatively to the core of the optical fiber and the focusing point of the second lens21brelatively to the reflecting mirror are kept unchanged when the optical path length is adjusted, a tomographic image can be obtained from the interference light based on the stabilized amount of reference light L2and deterioration of the image quality is prevented.

The optical path length adjusting means20,120and220described above may be applied to any one of the optical tomography system1shown inFIG. 1where SS-OCT is measured, the optical tomography system100shown inFIG. 9where SS-OCT is measured, and the optical tomography system200shown inFIG. 10where SS-OCT is measured. The optical path length adjusting means may be in the form of a composite of these optical path length adjusting means20,120and220.

This invention need not be limited to the embodiments described above. Though, inFIG. 1, the optical path length adjusting means20adjusts the optical path length of the reference light beam L2by way of example, it may adjust the optical path length of the measuring light beam L1. In this case, for instance, a three-way optical circulator is provided in the optical fiber FB2which guides the measuring light beam L1inFIG. 1, and the optical path length adjusting means20described above is in the port which is not in operation. Then by leading returning light from the object S to the optical path length adjusting means20and by returning the reflected light beam from the reflected mirror22at the end of the optical path length adjusting means20to the mixing means4, similar result can be obtained. Further, though, in the optical tomography systems100and200shown inFIGS. 9 and 10, the optical path length adjusting means20shown inFIG. 3is employed, by way of example, the optical path length adjusting means120and220shown inFIGS. 7 and 8may be employed.