Large bore PET and hybrid PET/CT scanners and radiation therapy planning using same

An imaging system comprises: a ring of positron emission tomography (PET) detectors; a PET housing at least partially surrounding the ring of PET detectors and defining a patient aperture of at least 80 cm; a coincidence detection processor or circuitry configured to identify substantially simultaneous 511 keV radiation detection events corresponding to electron-positron annihilation events; and a PET reconstruction processor configured to reconstruct into a PET image the identified substantially simultaneous 511 keV radiation detection events based on lines of response defined by the substantially simultaneous 511 keV radiation detection events. Radiation planning utilizing such an imaging system comprises: acquiring PET imaging data for a human subject arranged in a radiation therapy position requiring a patient aperture of at least about 80 cm; reconstructing said imaging data into a PET image encompassing an anatomical region to undergo radiation therapy; and generating a radiation therapy plan based on at least the PET image.

BACKGROUND

The following relates to the oncological arts, medical imaging arts, positron emission tomography (PET) arts, and related arts.

Radiation therapy has been shown to be effective in treating certain types of cancer. In these techniques, a high dosage of ionizing radiation is applied to the tumor or other malignant tissue. The typically high tissue growth rate and “unnatural” nature of the malignant tissue results in the ionizing radiation preferentially damaging or killing the malignant tissue; however, healthy tissue is also adversely impacted by the ionizing radiation. Accordingly, the ionizing radiation is applied in a tomographic or multi-beam configuration with the beam intensities and, optionally, cross-sectional beam profiles designed to deliver a therapeutic radiation dosage to the target tumor while keeping the radiation dosage received by neighboring critical organs below a design threshold.

Because anatomy varies amongst individuals, radiation therapy is planned on an individual basis for each patient. Anatomical data for the radiation therapy planning is acquired using computed tomography (CT) imaging which measures transmission of a tomographically rotating x-ray beam to enable reconstruction of a three-dimensional image of the internal patient anatomy. CT imaging has numerous advantages for this application—data acquisition is fast (of order a few minutes); it typically provides detailed structural information about both the target tumor and the surrounding critical organs; the x-rays mimic the transmission and absorption characteristics of the therapeutic radiation such that a therapeutic radiation absorption map can be constructed from the CT image using suitable tissue absorption correction factors; and CT scanners can be constructed with large bores.

A typical radiation therapy system has a patient aperture of order 80 centimeters. For example, some commercially available linear accelerator (linac)-based radiation therapy systems have patient apertures of 85 centimeters. Problematically, internal organ positions can shift, rotate, compress, expand, or otherwise differ depending upon the precise patient position. As a result, if the patient has to assume a different position in the CT scanner than in the radiation therapy system due to a smaller patient aperture of the former, then the anatomical images used for therapy planning may not accurately replicate the anatomical configuration during therapy.

By providing a CT scanner with a bore at least as large as that of the radiation therapy system, the patient can be positioned in the CT scanner in the same way the patient is positioned in the radiation therapy system. For example, the patient can have his or her arm or arms elevated or otherwise positioned in such a way as to not impede the therapeutic radiation beam; and, the patient can be positioned in precisely this same way in the large-bore CT scanner. This helps to ensure that organ positions are the same in both the planning CT images and in the radiation therapy system. One CT scanner that has a large bore suitable for radiation therapy planning is the Brilliance™ CT Big Bore™ system (available from Koninklijke Philips Electronics N.V., Eindhoven, the Netherlands), which has a patient aperture of 85 cm.

CT has been, and is expected to remain, a primary tool for acquiring patient anatomical data for planning. However, other imaging modalities could also be useful for radiation therapy planning.

Positron emission tomography (PET) imaging is a good candidate as a secondary imaging modality, because PET provides functional information that is complementary to the structural information provided by CT. In PET imaging, a radiopharmaceutical that emits positrons is administered to the patient. Each emitted positron interacts with a nearby electron in an electron-positron annihilation event that emits two oppositely directed 511 keV gamma rays. These gamma rays are detected substantially simultaneously by a radiation detector ring, thus defining a line-of-response along which the electron-positron annihilation event must (neglecting scattering) have occurred. In “time-of-flight” PET, the slight time difference (or lack thereof) between the two substantially simultaneous gamma ray detection events is used to further localize the annihilation event along the line of response.

The information provided by PET depends upon the radiopharmaceutical and its interaction with the patient physiology. A radiopharmaceutical injected into the bloodstream can inform about blood flow or blood perfusion. Since cancerous tumors tend to have dense vasculature, they are strongly visible in PET images that employ a blood-borne radiopharmaceutical. Similarly, radiopharmaceuticals including glucose cluster in areas of high metabolic activity, such as a cancerous tumor. On the other hand, if the tumor tissue is necrotic (perhaps due to success of previous radiation therapy sessions) then the tumor may be visible in CT images (since it remains structurally intact) but not in PET images (since it is necrotic and is no longer being actively fed by blood flow in the vasculature or metabolizing glucose).

A substantial obstacle to utilizing PET in radiation therapy planning and therapy monitoring is that PET scanners do not have the requisite combination of large patient aperture and high sensitivity. The radiopharmaceutical dosage is strictly limited due to safety concerns. As a result, a PET imaging session can take of order 30 minutes or longer to acquire sufficient data for reconstructing an image useful for oncology. The imaged volume increases with the square of the scanner diameter, which complicates scaling up the geometry to larger size (for example, to an 85 cm patient aperture). Stabilization of the patient in the PET scanner is another issue, especially in some hybrid CT/PET scanners in which the patient is supported by cantilevering in the PET gantry.

A blood borne radiopharmaceutical accumulates in areas of high blood concentration. These areas include the cancerous tumor due to its dense vasculature, but also include the brain and the bladder (the latter being the organ by which the radiopharmaceutical is ultimately excised from the body). The brain and bladder are therefore substantial sources of stray radiation that can lead to false gamma ray counts that degrade image quality. Use of energy-range and time-range filtering reduces these stray counts; however, in human-sized PET scanners these post-acquisition filtering techniques have been found to be insufficient, by themselves, to obtain clinical quality images for oncological applications.

With reference toFIG. 1, therefore, in existing human-sized PET scanners radiation shield rings are included to physically block this stray radiation from reaching the radiation detector ring.FIG. 1diagrammatically depicts the detector ring10in cross-section so as to show the radiation detectors comprising (in this embodiment) a scintillator12viewed by photomultiplier tube (PMT) detectors14. A patient S is arranged with a tumor or other malignancy of interest positioned at an isocenter16of the detector ring10. Side shield rings20made of lead or another material with high radiation stopping power extend radially inwardly from the ring of PET detectors so as to block a substantial portion of stray radiation from the brain region B and bladder or kidney region K from reaching the scintillator ring12. To further illustrate with some typical dimensions, in one commercial PET scanner (the Gemini™ Time-of-Flight PET/CT scanner, available from Koninklijke Philips Electronics N.V., Eindhoven, the Netherlands), the scintillator ring12has a diameter of 89 cm, and the shield rings20extend radially about 10 centimeters inward, so that the shield rings20have an inner diameter of 70 cm. As a result, an exterior housing22can have a patient aperture of no larger than about 70 cm, that is, no more than about 79% of the detector ring diameter. A patient aperture of 70 cm is large enough to receive a human subject, but is too small for performing imaging of a human subject in the same position as the subject would assume in the radiation therapy system. For example, the patient could not assume the conventional “frogleg” position used in radiation therapy of the colorectal region.

It has long been believed in the PET imaging arts that side shielding (such as the side shield rings20) are essential for obtaining oncological quality images. (As used herein, the term “oncological quality images” and the like encompasses images of high resolution and low noise that are suitable for medically acceptable analysis of cancerous tumors and other malignancies for patient health-critical purposes such as radiation therapy planning or other interventional therapy planning or planning decision-making.) For example, Mullani, U.S. Pat. No. 4,559,597 issued in 1985 discloses time-of-flight PET and considers the possibility of operating without side shields (called “septa” in Mullani), but concludes that omitting side shields introduces a substantial amount of scatter in the data and may not be acceptable for a clinically usable system. Mullani concludes that septa of length 12 cm provides optimal performance. Commercial oncology-quality PET scanners today continue to use side shielding of order 10 cm.

Other issues with oncological PET relate to scan time and patient inconvenience. In contrast to CT acquisition which is of order a few minutes, an oncological-quality PET scan can take 30 minutes or longer. Both faster acquisition and improved fusion of CT and PET images could be achieved by using a hybrid PET/CT scanner, in which the CT and PET gantries are arranged coaxially together to receive a subject via a common subject support system. Hybrid PET/CT scanners are available, as exemplified by the aforementioned Gemini™ PET/CT scanner. In most cases, CT is the “primary” imaging modality used in these systems, and hence is positioned closest to the patient loading end. When PET imaging is to be performed, the subject is transferred through the CT gantry and thence into the PET gantry.

However, this arrangement results in cantilevered support of the patient in the PET scanner, with the possible consequence of downward deflection of the patient support and resultant PET/CT image misalignment. Such misalignment can be corrected mathematically during the post-acquisition PET/CT image fusion processing. However, the correction increases computational complexity, and introduces yet another potential source of error in fusing CT and PET images for radiation therapy planning.

The cumulative effect of these issues has led to continued dominance of CT as the radiation therapy planning modality of choice, with PET imaging relegated to an infrequently used secondary planning modality. For example, a recent survey indicates that close to 90% of radiation therapy planning acquisitions employed CT imaging, while less than 10% of those acquisitions also employed PET imaging as a secondary modality. See IMV 2006 Radiation Oncology Census Market Summary Report, March 2007.

The following provides a new and improved apparatuses and methods which overcome the above-referenced problems and others.

BRIEF DESCRIPTION

In accordance with one disclosed aspect, an imaging system for imaging a human subject is disclosed, the imaging system comprising: a ring of positron emission tomography (PET) detectors; a PET housing at least partially surrounding the ring of PET detectors and defining a patient aperture of at least 80 cm; and a coincidence detection processor or circuitry configured to identify substantially simultaneous 511 keV radiation detection events corresponding to electron-positron annihilation events.

In accordance with another disclosed aspect, a method is disclosed, the method comprising: acquiring positron emission tomography (PET) imaging data for a human subject arranged in a radiation therapy position requiring a patient aperture of at least about 80 cm; reconstructing the PET imaging data into a PET image of the human subject which PET image encompasses an anatomical region to undergo radiation therapy with the human subject arranged in the radiation therapy position; and generating a radiation therapy plan based on at least the PET image.

In accordance with another disclosed aspect, an imaging system is disclosed for imaging a human subject, the imaging system comprising: a ring of positron emission tomography (PET) detectors defining a detector ring diameter; a PET housing at least partially surrounding the ring of PET detectors and defining a patient aperture that is smaller than and at least about 85% of the detector ring diameter; and a coincidence detection processor or circuitry configured to identify substantially simultaneous 511 keV radiation detection events corresponding to electron-positron annihilation events.

In accordance with another disclosed aspect, a system is disclosed comprising: a positron emission tomography (PET) imager including a ring of positron emission tomography (PET) detectors and a PET housing at least partially surrounding the ring of PET detectors and defining a PET patient aperture; wherein the PET patient aperture is at least as large as a patient aperture of a radiation therapy system configured to perform radiation therapy on a human subject in a radiation therapy position in accordance with a radiation therapy plan for the human subject generated based at least in part on PET images of the human subject acquired using the PET imager with the human subject in the radiation therapy position.

In accordance with another disclosed aspect, a patient support is disclosed, comprising: a subject table selectively horizontally translatable into a first medical system and into a second medical system; a plurality of spaced apart catchers arranged to support the subject table in the first medical system and in the second medical system; a height synchronization processor operatively coupled with the catchers to maintain a constant height of the subject table both in the first medical system and in the second medical system in the presence of a patient load; and a loading structure at which a subject is loaded onto the subject table.

In accordance with another disclosed aspect, an imaging system is disclosed for imaging a human subject, the imaging system comprising a ring of positron emission tomography (PET) detectors having no side shielding or side shielding of reduced radially inward extent. The ring of PET detectors has a fast response speed effective to enable a narrow coincidence time window for identifying substantially coincident 511 keV detection events, which narrow coincidence time window compensates for additional noise introduced by the lack of side shielding or by the side shielding of reduced radially inward extent.

DETAILED DESCRIPTION

With reference toFIG. 2, a detector ring100is similar to the detector ring10ofFIG. 1. The detector ring100includes the scintillator ring12viewed by photomultiplier tube (PMT) detectors14. The patient S is arranged with a tumor or other malignancy of interest positioned at the isocenter16of the detector ring100. However, the detector ring100omits the side shield rings20of the PET scanner ofFIG. 1. As a result, a modified PET housing122has a larger patient aperture than the housing22of the conventional detector ring10ofFIG. 1. For example, the scintillator ring12of the Gemini™ Time-of-Flight PET/CT scanner (available from Koninklijke Philips Electronics N.V., Eindhoven, the Netherlands) has a detector diameter of 89 cm defined by the scintillator ring12. However, in the Gemini™ PET scanner, the shield rings20extend radially about 10 centimeters inward, so that the shield rings20have an inner diameter of 70 cm. As a result, the exterior housing22of the conventional PET detector ring10can have a patient aperture no larger than about 70 cm, that is, about 79% of the detector ring diameter.

In contrast, the detector ring100ofFIG. 2has no side shield rings20, and accordingly is limited in patient aperture only by the scintillator ring12. If the dimensions of the Gemini™ Time-of-Flight PET/CT scanner are used for this component, then the detector ring100in some embodiments has a detector ring diameter of 89 cm. In some actually constructed embodiments, the housing122has a patient aperture of 85 cm (allowing for some physical thickness of the housing122) which comports with the patient aperture for some commercial radiation therapy systems, such as some commercial linac systems. This patient aperture of 85 cm is greater than 95% of the detector ring diameter (89 cm). More generally, it is desired to have the patient aperture be at least 80 cm, and in some more limited embodiments the patient aperature is at least about 85 cm to comport with a conventional linac patient aperture. In terms of percentages, the patient aperture should be at least 85% of the detector ring diameter, and in some embodiments the patient aperture is at least about 90% of the detector ring diameter, and in some further limited embodiments the patient aperture is at least about 95% of the detector ring diameter.

Using the illustrative example of the Gemini™ geometry with its PET detector ring diameter of 89 cm, a target patient aperture of 85% of this illustrative detector ring diameter is about 76 cm. For such an embodiment, it is contemplated to not wholly omit the side shielding rings20(as illustrated inFIG. 2), but rather to employ side shielding rings with a reduced inward radial extent. For example, again allowing for some physical thickness of the PET housing122, to achieve a patient aperture of about 76 cm one can include side shielding rings having an inward radial extent of about 3 cm or less. More generally, one can include side shielding rings extending radially inward from the ring of PET detectors a distance of between zero and no more than about three centimeters. In the embodiment illustrated inFIG. 2, the side shielding rings extend radially inward from the ring of PET detectors a distance of zero centimeters or, in other words, the side shielding rings are omitted entirely. In some embodiments, factors including: cost of the side shielding rings (even with reduced inward radial extent); reduced effectiveness of the side shielding rings with reduced inward radial extent as compared with the larger side shielding rings20of a conventional PET scanner; and the possibility of a non-uniform noise distribution across the radiation detectors due to partial but incomplete side shielding; makes it generally preferable to omit the side shielding rings entirely.

The skilled artisan would generally expect that the detector ring100diagrammatically depicted inFIG. 2would be unusable for radiation therapy planning. The skilled artisan would recognize that energy and time windowing can be used to mathematically remove or filter some of this stray radiation, but would nonetheless generally expect that stray radiation from the brain and bladder or kidney regions B, K, or from other sources outside the PET bore, would produce sufficient noise so as to degrade the PET image quality below that acceptable for radiation therapy planning applications. Indeed, to the inventors' knowledge all commercial human-sized PET systems (e.g., with patient aperture of about 70 cm or larger) heretofore have required side radiation shielding22having an inward radial extent of order 10 centimeters, as shown in prior artFIG. 1, in order to physically filter out (that is, physically block) much of the stray radiation from the brain and outer regions B, K or from elsewhere outside of the PET bore, so as to achieve PET image quality sufficient for clinical applications such as radiation therapy planning.

With continuing reference toFIG. 2and with further reference toFIG. 3, it is however recognized herein that the increased noise due to stray radiation from the outer regions B, K or from elsewhere outside of the PET bore can in practice be compensated by noise reduction achieved using radiation detectors of sufficiently high temporal and energy resolution. In other words, while heretofore it has been believed in the art that side shields (and consequent constriction of the patient aperture) are required to obtain ecological quality images, it is recognized herein that one can omit the side shielding rings20and achieve noise reduction by using high-speed radiation detectors to enable narrow time- and energy-windowing during coincidence detection. Suitably high-speed radiation detectors can be constructed using scintillator crystals of materials such as LYSO, LSO, LFS, MLS, LaBr, LuI, LuAG, LuAP, or LGSO crystals, which exhibit rapid scintillation decay times of order a few tens of nanoseconds or shorter. Further, by using high speed detectors one can optionally implement a time-of-flight PET image data reconstruction technique, which provides still further noise reduction.

FIG. 3depicts (in an overhead view) a hybrid CT/PET scanner including a PET scanner with the detector ring100omitting the side shielding rings and accordingly including the PET housing122with large patient aperture (e.g., at least 80 cm, and more preferably at least about 85 cm). The PET detector ring100is in some embodiments substantively similar to the PET scanner portion of the Gemini™ Time-of-Flight PET/CT scanner (available from Koninklijke Philips Electronics N.V., Eindhoven, the Netherlands) which includes the scintillator ring12constructed of 4×4×22 mm lutetiumyttrium oxyorthosilicate (LYSO) crystals defining a detector ring diameter and viewed by the illustrated PMT detectors14positioned at a larger diameter than the scintillator ring12and defining an Anger-logic detector configuration. LYSO crystals advantageously have sufficiently rapid scintillation decay to provide sub-nanosecond temporal resolution enabling time-of-flight localization of the electron-hole annihilation event along the line-of-response. LYSO crystals are used in the current Gemini™ system, but other scintillators having fast scintillation decay are also contemplated, such as LSO, LaBr, or other crystals. In yet other contemplated embodiments, the PMT detectors14are contemplated to be replaced by silicon photomultiplier (SiPM) devices, semiconductor photodetectors, or the like. In still yet other contemplated embodiments, it is contemplated to replace the scintillator ring/photodetector assembly by a ring of direct radiation detectors, such as semiconductor photodetectors configured to directly detect 511 keV radiation without an intermediate scintillation event.

In some embodiments, the PET scanner may be provided alone. However, for radiation therapy planning applications, it is anticipated that CT will likely remain the primary planning mode of choice among many oncologists. Accordingly, the embodiment illustrated inFIG. 3employs a hybrid CT/PET scanner (shown in overhead view inFIG. 3) that includes, in addition to the PET detector ring100, a CT scanner130having a bore arranged coaxially with the bore of the PET detector ring100, and further including a common patient support with a patient couch or loading structure132configured to load a patent into either the CT scanner130(as illustrated) or into the PET detector ring100. To facilitate imaging of a human subject arranged in a radiation therapy position, the CT scanner130has a patient aperture of at least about 80 cm, and more preferably at least about 85 cm. In some embodiments, the PET detector ring100and the CT scanner130both have the same patient aperture size, so that it is ensured that a human subject arranged in a radiation therapy position that fits into one of the scanners100,130will also fit into the other of the scanners. A system controller134provides control interfacing between the hybrid CT/PET scanner and a suitable user interface such as a diagrammatically illustrated computer140including one or more user input devices such as an illustrated keyboard142, a mouse or other pointing device, or so forth, and one or more user output devices such as an illustrated display144, a printer or other marking engine, or an Internet or local area network (LAN or wireless LAN) interface, or so forth.

The CT scanner130is in some embodiments substantively similar to the Brilliance™ CT Big Bore™ system (available from Koninklijke Philips Electronics N.V., Eindhoven, the Netherlands), which has a patient aperture of 85 cm, a 60-70 cm field of view, and employs a 60 kW generator coupled with an x-ray tube drivable at 20-500 mA tube current with a dynamic focal spot. However, other CT scanners having a sufficiently large patient aperture are also contemplated for use as the CT scanner component130of the hybrid CT/PET scanner.

With reference toFIG. 3, CT data are acquired by the CT scanner130and collected and stored or buffered in a CT data buffer150, and are reconstructed by a CT reconstruction processor152to generate CT images that are stored in a CT images memory154. The CT reconstruction processor152can employ any reconstruction algorithm suitable for reconstructing CT projection data, such as a filtered backprojection algorithm, an iterative reconstruction technique, or so forth.

Processing of data collected by the PET detector ring100entails processing by a coincidence detection processor or circuitry160that identifies substantially coincident 511 keV gamma ray detection events that are likely to correspond to electron-hole annihilation events. The coincidence detection processor or circuitry160preferably performs energy windowing on the individual radiation particle detection events to filter out radiation detection events corresponding to particles (the term “particle” being used broadly herein to encompass both photons and conventional particles such as electrons and protons) having energies substantially different from 511 keV. The coincidence detection processor or circuitry160preferably also performs time windowing on prospective pairs of radiation particle detection events to filter out radiation detection event pairs that are temporally separated by time intervals too large to correspond to electron-hole annihilation events. As used herein, substantially coincident 511 keV gamma ray detection events are “substantially coincident” if they are separated by a time interval less than a time window corresponding to a maximum expected time separation for detection of two oppositely directed 511 keV gamma rays emanating from a single electron-positron annihilation event. For example, if the detector ring has a radius of 89 cm, then a suitable time window may be defined as 89 cm divided by the speed of light (c=3×1010cm/s for a vacuum), that is, a time window of about 3.0 ns. A narrower time window may be suitable if the region in which electron-positron annihilation events are expected to occur is smaller than the 89 cm radius of the detector ring. A wider time window is also contemplated, for example to accommodate somewhat coarser detector temporal resolution.

The output of the coincidence detection processor or circuitry160is a list of 511 keV gamma ray detection event pairs likely to correspond to electron-hole annihilation events, along with time stamp information about the precise times of the two 511 keV gamma ray detection events making up the pair. This information is suitably stored or buffered in a time-of-flight PET (TOF-PET) data buffer162in a listmode format or in another format that contains the relevant information including detector locations for the two 511 keV gamma ray detection events making up the pair and temporal information about the two 511 keV gamma ray detection events making up the pair.

Because the side shielding rings20are omitted in the PET detector ring100, relatively higher “false” radiation events are expected to be detected by the detector ring100as compared with a side-shielded detector ring such as the detector ring10depicted inFIG. 1. However, it is recognized herein that by configuring the coincidence detection circuitry or processor160in conjunction with high-speed radiation detectors to provide a sufficiently narrow temporal coincidence window, for example a temporal window of about 10 ns or shorter, and more preferably about 6 ns or shorter, and a sufficiently narrow energy window of about 15% FWHM, and more preferably less than or about 12%, centered on 511 keV, oncological quality images can be obtained in spite of the omission of the side shielding rings20. A coincidence temporal window of about 10 ns or shorter can be usefully employed in conjunction with a scintillator having scintillation decay times of a few tens of nanoseconds or shorter, operated using Anger logic or other data analysis providing radiation particle detection event resolution of order a few nanoseconds or less. A narrow temporal window for coincidence detection is recognized herein to be highly effective for filtering out radiation from outlying regions such as the brain region B or the kidney or bladder region K because radiation events emanating from these outer regions cannot generate two simultaneous 511 keV particles that are both detected by the detector ring100. Even if the positron-emitting radiopharmaceutical is present in the outer regions B, K, the oppositely directed 511 keV particles generated by an electron-positron annihilation event in an outer region cannot both be detected by the detector ring100because only one of the two 511 keV particles (at most) is directed toward the detector ring100. Accordingly, a narrow time window of about 10 ns or less, and more preferably about 6 ns or less, coupled with an energy window centered at 511 keV with a FWHM of about 15% or less, and more preferably about 12% or less, is highly effective for filtering out these spurious radiation detection events, and this effective coincidence temporal filtering is recognized herein to eliminate the need for the side shielding rings20.

A time-of-flight PET (TOF-PET) reconstruction processor164reconstructs the listmode or otherwise-formatted TOF-PET data to generate a PET image that is stored in a PET images memory166. The TOF-PET reconstruction processor164can employ any reconstruction algorithm suitable for reconstructing into a PET image the substantially simultaneous 511 keV radiation detection events identified by the coincidence detection processor or circuitry160. The TOF-PET reconstruction is based on time-of-flight localized lines of response defined by the identified substantially simultaneous 511 keV radiation detection events, and can employ various reconstruction techniques such as filtered backprojection, iterative backprojection, or so forth, modified or adjusted to take into account additional information provided by the time-of-flight localization. Although the illustrated reconstruction processor164employs time-of-flight localization which advantageously further reduces noise, it is also contemplated to omit time-of-flight localization from the PET image reconstruction processing, and to rely solely on a narrow coincidence time window enabled by use of fast detectors to provide sufficient noise reduction to compensate for omission of the side shields20. The use of high speed detectors and the consequent ability to use narrow coincidence time windowing (for example, using a coincidence time window of about 10 ns or less, and more preferably about 6 ns or less) and narrow energy windowing (for example, using an energy window of about 15% FWHM or less, and more preferably about 12% FWHM or less) provides an effective reduction in data noise. This noise reduction, in turn, compensates for the increased noise of the PET detector ring100compared with the conventional PET detector ring10caused by omission of the side shielding rings22in the PET detector ring100. Accordingly, it is unexpectedly obtained that the PET detector ring100which omits the side shielding rings22, operating in conjunction with a fast detector system employing, for example, fast scintillators12made of LYSO, LSO, LaBr, or another crystal type exhibiting fast scintillation decay, can be used to generate oncology-quality images of a human subject arranged in a radiation therapy position requiring a patient aperture of at least about 80 cm, and in some embodiments requiring a patient aperture of at least about 85 cm. Optionally, TOF-PET reconstruction processing is used to further reduce noise. Synergistically, the same high-speed detectors that enable narrow coincidence time windowing also facilitate TOF-PET reconstruction processing by providing temporal resolution sufficient to provide TOF spatial localization.

The large patient aperture of the PET detector ring100, which is enabled by the unexpected recognition that the side shields20can be omitted, enables generation of high quality PET images of a human subject arranged in a radiation therapy position. The optional large-bore CT scanner130similarly enables generation of high quality CT images of the human subject arranged in the radiation therapy position. A fusion/display processor170suitably fuses or spatially registers the CT and PET images using a non-deformational spatial registration algorithm. The use of a non-deformational spatial registration algorithm is enabled by the ability of both the CT scanner130and the PET detector ring100to image the subject in the same radiation therapy position. Accordingly, there is no need to deform either the CT image or the PET image in order to achieve spatial registration. Indeed, in some embodiments the fusion/display processor170employs a completely rigid spatial registration algorithm for spatially registering or fusing the CT and PET images.

The fused or spatially registered CT and PET images can be formatted by the fusion/display processor170for display on the display144of the computer140. Additionally or alternatively, a radiation therapy planning processor172can receive the spatially registered or fused CT and PET images and can perform radiation therapy planning using this patient-specific input information. The radiation therapy planning is typically a user-interactive process, in which a radiologist, oncologist, or other suitably trained person delineates the tumor or other malignancy as well as critical organs or other critical anatomy for which radiation exposure is to be limited or constrained. These features are suitably delineated by the trained person using the user interface140and a suitable graphical input such as a touchscreen, mouse, or the like to enable the trained person to draw a line around or otherwise delineate the features in different views or planes (e.g., axial, sagittal, and coronal views, or other views comporting with the spatial orientation or shape of the feature being delineated). The radiation therapy planning processor172then calculates a radiation therapy plan that is expected to deliver a desired dosage of radiation to the tumor or other malignancy while keeping the dosage delivered to the delineated critical organs to below a specified level or in compliance with other constraint. The radiation therapy planning processor172plans the radiation therapy by computing appropriate values for adjustable parameters of the radiation therapy system, such as radiation beam intensity and area profile (controllable, for example, using a multi-leaf collimator to open or shutter selected beamlets of the radiation beam). For a tomographic radiation therapy system, the beam intensity and area profile may be adjusted as a function of angular position of the radiation source (e.g., linac) as the source revolves around the human subject. For a multi-beam radiation therapy system, the different radiation beams are differently adjusted to effectuate the desired dosage distribution.

The radiation therapy plan generated by the radiation therapy planning processor172is carried out by a suitable radiation therapy system, such as an illustrated tomographic radiation therapy system180(diagrammatically shown in a perspective view inFIG. 3), or a fixed multi-beam radiation therapy system. The illustrative tomographic radiation therapy system180includes a patient support182so as to support the human subject arranged in the radiation therapy position for exposure to a rotating radiation source184in accordance with the radiation therapy plan. Although illustrated as having separate patient supports132,182, it is contemplated to have a common patient couch or loading structure used for both the imaging and radiation therapy systems, for example in the form of a “hybrid” linac/PET system. That is, it is contemplated to integrate the radiation therapy system with the PET detector ring100, and optionally with the CT scanner130, so that they are coaxially arranged with a single patient support system configured to move the human subject between the different systems. The use of a single support system to coaxially move the patient into the imaging and radiation therapy sub-systems enables the patient to hold or be constrained in a preselected fixed position in all modalities. It becomes unnecessary to attempt to reposition the patient in the same position for the planning imaging data acquisition and radiation therapy phases. In other embodiments, the radiation therapy system180and the CT/PET system may be located in different rooms, different buildings, or so forth.

The CT imaging can be used to determine radiation absorption or attenuation characteristics for use in correcting the PET imaging data for absorption, or for use in the radiation therapy planning. Having the patient in the same radiation therapy position during CT imaging, PET imaging, and radiation therapy enables such absorption or attenuation correction to be performed more accurately.

As used herein, the term “radiation therapy planning” and similar terminology is intended to encompass the initial radiation therapy planning as well as any subsequent radiation therapy monitoring, updating, adjusting, or so forth. For example, PET imaging to assess whether radiation therapy sessions performed to date have converted a tumor (or portion thereof) to a necrotic state qualify as radiation therapy planning, as that term is used herein. (Indeed, such assessment PET imaging may alter the radiation therapy, as for example if the tumor is indeed partially or wholly necrotic then scheduled future radiation therapy sessions may be adjusted or canceled altogether). Moreover, the radiation therapy can employ any of various types of therapeutic radiation, such as an electron beam, gamma beam, proton beam, or so forth.

The illustrated computational or processing components134,152,160,164,170,172can be variously embodied and variously integrated or separated. For example, in one contemplated arrangement the computer140including suitable software or programming embodies at least the imaging system controller134and the reconstruction processors152,164. The coincidence detection processor or circuitry160can be embodied by the computer140, or can be embodied by electronic components disposed on or in the PET detector ring100. The latter arrangement can be beneficial for ensuring sufficient processing and signal propagation speeds to enable TOF temporal resolution. For example, in some embodiments on-board electronics of the PET detector ring100perform analog-to-digital (A/D) conversion of the radiation particle energy and generate a digital timestamp for each radiation particle detection event so that listmode-formatted data of the form (energy, detector location, time) or the like is outputted off the PET detector ring100. This listmode-formatted data is then analyzed at the computer140or another component to perform energy windowing, time windowing, and coincidence detection. In such embodiments, the coincidence detection processor or circuitry160is distributed between the PET detector ring100and one or more other, “off-gantry” components. Various other combinations or separations or distributions of the various computational or processing components134,152,160,164,170,172are also contemplated.

It is also to be appreciated that the various computational or processing components134,152,160,164,170,172can be variously embodied as digital data storage elements that store software or other instructions executable by the computer140and/or another digital processor or processors to perform the described processing operations such as windowing, coincidence detection, image reconstruction, scanner control, and so forth. For example, the digital data storage element or elements may include one or more of the following: a magnetic disk; a magnetic tape; an optical disk; a random access memory (RAM); a read-only memory (ROM); a FLASH memory; a remote Internet or LAN server storage medium; or so forth.

With reference toFIG. 4, an illustrative embodiment of the patient support system for the CT/PET scanner including the patient couch or loading structure132is described. In the illustrated hybrid scanner embodiment, the CT scanner130is assumed to be the “primary” or most commonly used imaging modality, and accordingly is positioned closest to the patient couch or loading structure132. In this way, if only CT imaging is to be performed, then the human subject need only be moved a relatively short distance into the CT scanner130. On the other hand, if PET imaging is to be performed, the human subject is moved through the CT scanner130and thence into the coaxially aligned patient aperture of the PET detector ring100. It is also contemplated to arrange the PET and CT scanners in reverse order in the hybrid system, that is, with the PET scanner positioned closest to the patient couch or loading structure132. In other contemplated embodiments, the patient couch or loading structure132may be arranged between the PET and CT scanners. To achieve a two stage subject movement as in the illustrated embodiment (or, alternatively, as in a PET/CT scanner in which the patient couch or loading structure is proximate to the PET scanner and not between the PET and CT scanners), the illustrated patient support system includes a top table or pallet200and a bottom table or pallet202. The two tables or pallets200,202are aligned together (as illustrated inFIG. 4) when the human subject is loaded at the patient couch or loading structure132, and move together to position the human subject in the CT scanner130. If it is desired to move the human subject further, into the PET detector ring100for PET imaging, then the bottom table or pallet202locks into position in the CT scanner using a suitable locking mechanism (not shown) that is activated by sufficient travel of the combined pallets200,202into the CT scanner. Once the bottom pallet202locks into position responsive to sufficient forward travel, the top pallet200continues to move by itself (that is, moves relative to the stationary locked bottom pallet202) to transfer the subject into the PET detector ring100. The reverse process is performed to return the human subject back together with the pallets200,202onto the patient couch or loading structure132for convenient unloading.

In some embodiments, one or both pallets may be supported in a cantilevered position when extended into the imaging systems100,130. Such an arrangement can lead to downward deflection of the cantilevering end of the pallet, which can cause misregistration of the CT and PET images. Such misregistration is suitably corrected by the fusion/display processor170.

In the illustrated embodiment, the pallets200,202are not cantilevered, but rather are supported by additional spaced-apart catchers of the patient support system. A CT catcher210is arranged to catch or support the end of the bottom pallet202distal from the patient couch or loading structure132when the pallets200,202are extended into the CT scanner130. A PET catcher212is arranged to catch or support the end of the top pallet200distal from the patient couch or loading structure132when the top pallet200is further extended into the PET detector ring100. Additional catchers, such as an illustrated intermediate “open position” catcher214(shown in a retracted “non-use” position inFIG. 4) can be included to provide further support for one or both pallets200,202.

The patient couch or loading structure132and the catchers210,212,214(the latter when extended into the operational position) each have a height that is adjusted to maintain a level of the pallets200,202respective to a suitable reference, such as a central axis220of the coaxially aligned CT and PET patient apertures, or respective to another reference. In some embodiments, these heights are adjusted manually in an initial patient support system alignment process. For example, the alignment can utilize a phantom (not shown) having a defined height reference point mounted on the top pallet200, and alignment lasers are suitably used to ensure that the height reference point of the phantom remains at the designated height as it is moved into the CT scanner130and thence into the PET detector ring100. However, this approach may be insufficient to maintain the subject table200,202at a constant height effective to comply with the Task Group 66 (TG-66) subject table deflection standard promulgated by the American Association of Physicists in Medicine (AAPM) and utilized in the industry as a standard with which medical imaging subject supports preferably comply. For example, subjects of different weights may produce different amounts of table sag, which is not compensated by the manual table support height alignment process.

In the illustrated embodiment, the catchers210,212,214each include automatic height adjustment actuator, for example a hydraulic piston, pneumatic piston, or other automatic actuator (not shown), and a height synchronization processor222operates the automatic height adjustment actuators of the catchers210,212,214to maintain the target height for the tables200,202, preferably at a precision complying with the TG-66 subject table deflection standard promulgated by the AAPM. The height synchronization processor222can operate in various ways. In an open-loop approach, the weight of the human subject about to be imaged is input by the radiologist, oncologist, or other trained operator, or is measured using a weight scale (not shown) built into the patient couch or loading structure132. The height synchronization processor222then adjusts the actuators of the catchers210,212,214to values obtained from a look-up table, mathematical calibration function, or other source so as to compensate for the input or measured weight of the subject. In a closed-loop approach, sensors (not shown) in the catchers210,212,214actively measure the heights of the respective catchers210,212,214as they are loaded down with the pallet or pallets200,202bearing the weight of the human subject to be imaged. The height synchronization processor222then adjusts the actuators using a feedback controller or feedback control algorithm to maintain setpoint heights for the catchers210,212,214.

InFIG. 4, the height synchronization processor222is diagrammatically illustrated as integrated with the patient couch or loading structure132. In other embodiments, the height synchronization processor222may be embodied as the computer140executing suitable software, or as a digital storage medium storing said software, or may be otherwise embodied and/or located. Moreover, if the linac or other radiation therapy system180is integrated coaxially with the imaging system using a common patient couch or support system (diagrammatically indicated in phantom and in part inFIG. 4), then additional catchers230can be included and height-synchronized as described for the catchers210,212,214in order to maintain a common calibrated height of the patient in the imaging system100,130and in the radiation therapy system180. By interposing the subject support132between the radiation therapy system180and the imaging systems100,130, spatial separation therebetween is enhanced so as to reduce a likelihood of detrimental interaction between the radiation therapy system180and the imaging systems100,130. However, it is also contemplated to place the subject support at one end or extremity of the coaxial arrangement of radiation therapy and imaging systems.