Membrane for alveolar bone regeneration

A membrane for alveolar bone regeneration to guide bone generation by adapting to a bone graft material, which fills a bone defect area, includes a central hole through which an implant is inserted into an alveolar bone, wherein the membrane includes: a coupling part to couple the membrane with the implant; a side bending part that is downwardly bent from the coupling part to have an overall curved shape with a gentle slope; and lateral covering parts that protrude from edges of the side bending part and are bent and curved toward an alveolar bone defect area, wherein the side bending part and the lateral covering parts are pre-formed in three-dimensions to fit a final shape of the alveolar bone that is to be regenerated.

TECHNICAL FIELD

The present invention relates to a membrane for alveolar bone regeneration that is disposed on a bone defect area and adapts to a graft material to guide bone regeneration, and more particularly, to a membrane for alveolar bone regeneration enabling reduced operation time and convenient manufacture as no local area excessively protrudes since separate trimming and bending are unnecessary and enabling a high success rate of the operation by preventing failure of an alveolar bone regeneration due to a surgical exposure.

BACKGROUND ART

Among non-absorptive materials, a four-sided perforated titanium plate has been generally used for a conventional guided bone regeneration (GBR) technique.

In the conventional GBR technique, a practitioner first recognizes a shape of a location where a bone defect has occurred, appropriately trims the four-sided membrane to a desired shape, adapts to the defect area by three-dimensionally bending the four-sided membrane, and lastly uses a separate screw to fix the four-sided membrane.

However, after recognizing the shape of the bone defect, the conventional GBR technique includes trimming of the membrane to a desired shape and bending of the membrane later, and thus the bone defect area may not be completely adapted and an operation time may be increased. Also, due to an excessive crumpling phenomenon during the bending process, that is, the local area being bent excessively protrudes, the protruded area breaks through gingiva during a period of guiding bone regeneration. Then, the area is infected from the outside and becomes a main factor for bone regeneration failure. Moreover, a large area is required to be incised to remove the screw that is implanted to fix the membrane, and thus, an operation time may be increased, and swelling may occur due to bleeding, which may be painful to a patient. Therefore, the operation has been burdensome to both practitioners and patients.

DETAILED DESCRIPTION OF THE INVENTION

Technical Problem

The present invention provides a membrane for alveolar bone regeneration that is customized by predicting a bone defect shape, wherein the membrane is three-dimensionally trimmed and bent at the same time to avoid local protrusion, and more particularly to, a membrane for alveolar bone regeneration that enables reduced operation time, convenient manufacture, high operation success rate, and less swelling and pain to a patient at the same time.

Technical Solution

According to an aspect of the present invention, there is provided a membrane for alveolar bone regeneration to guide bone generation by adapting to a bone graft material, which fills a bone defect area, wherein the membrane for alveolar bone regeneration includes a coupling part including a central hole through which an implant is inserted into an alveolar bone; a side bending part that is downwardly bent from the coupling part to have an overall curved shape with a gentle slope; and lateral covering parts that protrude from lateral portions of the side bending part and are bent and curved toward an alveolar bone defect area, wherein the side bending part and the lateral covering parts are pre-formed in three-dimensions to fit a final shape of the alveolar bone that is to be regenerated.

The lateral covering parts may be easier to bend than the side bending part.

A plurality of first holes may be formed in the side bending part, and a plurality of second holes may be formed in the lateral covering parts.

The side bending part may include a first bending part that is bent in a direction away from the coupling part and a second bending part that is bent in a direction towards the coupling part.

The first holes may only be formed in the first bending part.

The first holes at the lowermost part of the first bending part may be aligned in a concave dish shape.

A diameter of the first holes may be greater than a diameter of the second holes.

A total hole area of the first holes in the side bending part per unit area may be smaller than a total hole area of the second holes in the side bending part per unit area.

A diameter of the first holes may be in a range of about 0.9 mm to about 2.0 mm, and a diameter of the second holes may be in a range of about 0.1 mm to about 0.5 mm.

The membrane for alveolar bone regeneration may further include lower covering parts that protrude downward from a lower portion of the side bending part and bent inwardly.

A plurality of third holes may be formed in the lower covering parts.

The first holes may be formed in the side bending part, and a diameter of the third holes may be smaller than a diameter of the first holes.

At least two of the lower covering parts may be separated at an equal interval.

The lower covering parts may be symmetrically disposed about a center axis of the side bending part.

The lower covering parts may be pre-formed in three-dimensions to fit a final shape of the alveolar bone that is to be regenerated.

A plurality of fourth holes may be formed in the coupling part.

The membrane for alveolar bone regeneration may further include coupling lateral covering parts protruding from lateral portions of the coupling part and bent to cover the bone graft material.

A plurality of fifth holes may be formed in the coupling lateral covering parts.

The membrane for alveolar bone regeneration may further include coupling upper covering parts protruding from an upper portion of the coupling part and bent to cover the bone graft material.

A plurality of sixth holes may be formed in the coupling upper covering parts.

At least two of the coupling upper covering parts may be separated at an equal interval.

The coupling upper covering parts may be symmetrically disposed about a center axis of the coupling part.

The coupling upper covering parts may be pre-formed in three-dimensions to fit a final shape of the alveolar bone that is to be regenerated.

A surface of the membrane for alveolar bone regeneration may be coated with a tin-coating layer, anodized, or heat-treated to realize various colors.

According to another aspect of the present invention, there is provided a membrane for alveolar bone regeneration to guide alveolar bone regeneration of an alveolar bone defect area by covering an opened wall of the alveolar bone defect area, wherein the membrane for alveolar bone regeneration includes a body part covering the alveolar bone defect area; and protruding parts protruding from the body part and including a concave groove that is concave in a direction towards the body part, wherein if the largest protrusion height of the protruding parts is referred to as h1and the largest depth of the concave groove is referred as h2, the largest protrusion height h1is greater than the largest depth h2, thus a crumpling phenomenon occurring during a bending process of the protruding parts from the body part as one region of the protruding parts protrudes more than other regions can be prevented.

The concave grooves may be concave in an opposite direction to a protruding direction of the protruding parts.

Any one of the protruding parts may include a pair of bending lines that are separate from each other, wherein one of the bending lines is formed at a borderline of the body parts and the protruding parts, and the other bending line is formed to meet a bottom of the concave groove.

The body parts may include a coupling part that enables the membrane to couple with an implant; and a side bending part that is bent from the coupling part to cover a side of the alveolar bone.

A central hole through which an implant may be inserted into the alveolar bone is formed in the coupling part.

A plurality of first holes with a smaller diameter than the central hole may be formed in the side bending part.

The side bending part may include a first bending part that is bent in a direction away from the coupling part and a second bending part that is bent in a direction towards the coupling part.

The first holes at the lowermost part of the first bending part may be aligned along a concave line of a “C” shape.

The protruding parts may include coupling upper covering parts that protrude from an upper portion of the coupling part.

The protruding parts may include coupling lateral covering parts that protrude from lateral portions of the coupling part.

The protruding parts may include lateral covering parts that protrude from lateral portions of the side bending part.

A plurality of second holes with a smaller diameter than the first holes may be formed in the lateral covering parts.

A diameter of the first holes may be in a range of about 0.9 mm to about 2.0 mm, and a diameter of the second holes may be in a range of about 0.1 mm to about 0.5 mm.

The protruding parts may include lower covering parts that protrude from a bottom portion of the side bending part.

A plurality of third holes with a smaller diameter than the first holes may be formed in the lower covering parts.

A diameter of the first holes may be in a range of about 0.9 mm to about 2.0 mm, and a diameter of the third holes may be in a range of about 0.6 mm to about 0.8 mm.

A surface of the membrane for alveolar bone regeneration may be coated with a tin-coating layer, anodized, or heat-treated to realize various colors.

The membrane may be pre-formed in a three-dimensional stereoscopic curve shape in a direction of the alveolar bone so as to fit a final shape of an alveolar bone to be regenerated.

Advantageous Effects

A membrane for alveolar bone regeneration according to an aspect of the present invention enables easy, rapid, and convenient operation for a practitioner so that a clinical success rate may be increased, and enables reduced operation time for a patient so that swelling may be reduced. Also, as the burdensome operation time is reduced, both the practitioner and the patient may be satisfied.

Particularly, a membrane for alveolar bone regeneration that are pre-formed in three-dimensions to fit various shapes of bone defects, compared to the conventional products, is provided, thus additional processes, such as trimming and bending, may be minimized, and a protruding phenomenon due to bending of the membrane may be minimized, thus failure of alveolar bone regeneration due to the exposure may be prevented. Therefore, an overall degree of operation completeness may be increased.

BEST MODE

Hereinafter, membranes for alveolar bone regeneration according to exemplary embodiments of the present invention will be described in greater detail with reference to the attached drawings.

A membrane for alveolar bone regeneration100according to an embodiment of the present invention covers an opened wall of an alveolar bone defect area to guide the alveolar bone regeneration at the alveolar bone defect area. The two-dimensional plan view of the membrane for alveolar bone regeneration100ofFIG. 1illustrates that a shape of the membrane for alveolar bone regeneration100is trimmed to fit the shape of a bone defect that is pre-recognized.FIGS. 2 and 3illustrate a shape of the pre-trimmed two-dimensional membrane for alveolar bone regeneration100that is three dimensionally bent with a predetermined bending device.

In this regard, the membrane for alveolar bone regeneration100according to an embodiment of the present invention is manufactured by performing three-dimensional trimming and bending in advance by using the predetermined bending device, rather than a practitioner instantly trimming and bending a membrane to fit the shape of the bone defect of a patient right before the operation. Thus, the membrane for alveolar bone regeneration100is characterized as being formed in advance into a shape with a stereoscopically surface curved in a direction of an alveolar bone to fit the alveolar bone, which is to be regenerated.

The membrane for alveolar bone regeneration100includes body parts and protruding parts. Here, the body parts, which may cover the alveolar bone defect area, include a coupling part120and a side bending part150. The protruding parts, which protrude by being extended from the body parts, include coupling lateral covering parts130, coupling upper covering parts140, lateral covering parts160, and lower covering parts170. Here, if the largest protrusion height of the protruding parts is referred to as h1and the largest depth of a concave groove143is referred as h2, the largest protrusion height h1is greater than the largest depth h2, thus a crumpling phenomenon, which occurs when one region of the protruding parts is more protruded than other regions of the protruding parts, may be prevented during a process of bending the protruding parts from the body parts.

The coupling part120includes a central hole121through which an implant80is inserted into an alveolar bone81, and thus the membrane for alveolar bone regeneration100is coupled with the implant80. The coupling part120adapts to an upper portion of a region where a bone graft material82is stacked up for the bone defect area with a generally flattened shape. The central hole121is formed in a central area of the coupling part120, and a plurality of fourth holes122are distributed in a radial form around the central hole121. The fourth holes122may have a smaller size than the central hole121. The fourth holes122enable the bone graft material82to firmly and stably bone fuse with peripheral bone tissue by activating a physiological reaction between the bone graft material82filling the bone defect area and blood of the peripheral bone tissue, and thus, a size of the fourth holes122may be an appropriate size for the bone fusion.

The coupling lateral covering parts130, which are curved from the coupling part120to cover sides of the bone graft material82, protrude from lateral portion of the coupling part120. The coupling lateral covering parts130may be curved downward to cover the bone graft material82. The coupling lateral covering parts130may be formed protruding from parts of the lateral portion of the coupling part120, and accordingly, the bending of the coupling lateral covering parts130may be conveniently performed. In particular, the coupling lateral covering parts130are provided to adapt to a mesial or distal side of the alveolar bone, and the coupling lateral covering parts130are formed to extend in a direction toward a neighboring tooth.

The coupling lateral covering parts130include a plurality of fifth holes131. The fifth holes131may have shape of a circle or an irregular circle. Also, the fifth holes131may have a smaller diameter than the fourth holes122, if necessary. Accordingly, a greater number of holes may be formed in a small area. In this regard, overall flexibility increases and the bending may be conveniently performed as the number of fifth holes131increases.

The coupling upper covering parts140, which are disposed on the coupling part120, may be curved inwards to cover the bone graft material82. Two of the coupling upper covering parts140may be disposed side by side, and the coupling upper covering parts140may be symmetrical about a center axis of the concave groove143formed in the middle of the two coupling upper covering parts140. Here, the concave groove143has a concave shape in a direction towards the body parts from upper portion of the coupling upper covering parts140, and thus the concave groove143may be concave toward an opposite direction from a protrusion direction of the coupling upper covering parts140. That is, as shown inFIG. 1, the coupling upper covering parts140protrude upward from the coupling parts120, while the concave groove143may be concave downward the coupling upper covering parts140. Here, if the largest protrusion height of the coupling upper covering parts140, which are also the protruding parts, is referred to as h1and the largest depth of the concave groove143is referred as h2, the largest protrusion height h1is greater than the largest depth h2. In addition, a pair of bending lines may be separated from each other on the coupling upper covering parts140, which are also the protruding parts. Here, among the bending lines, one bending line l2(also referred to as “second bending line”) may be formed at a borderline of the coupling part120, which is one of the body parts, and the coupling upper covering parts140, which are also the protruding parts, and the other bending line l1(also referred to as “first bending line”) may be formed to meet a bottom of the concave groove143.

Here, the bending line l2may connect a pair of second bending points where the coupling part120and the coupling upper covering parts140meet, and the other bending line may be separately located above the second bending points and passes an bottom point of the concave groove143. Here, the bending line l1may be located above and parallel to the bending line l2.

The coupling upper covering parts140may be divided into a first upper part141including each part of the coupling upper covering parts140and second upper parts142both protruding from the first upper part141, wherein the concave groove143is formed between the second upper parts142. In this regard, the first upper part141may be primarily bent along the second bending line l2, and then the second upper part142may be secondarily bent along the first bending line during a process of bending the coupling upper covering parts140from the coupling part120, which is one of the body parts. Here, the primary bending and the secondary bending may be separately performed, but the processes are not limited thereto and may occur simultaneously and spontaneously. In this regard, as the secondary bending is performed, a whole bending curve line may have a gentle slope, and thus a crumpling phenomenon locally occurring at an area where the bending processes start may be prevented. Also, even when only one of the bending processes is performed, the overall curve may have a gentle slope, and thus the crumpling phenomenon, which occurs when one region protrudes more than other regions, may be prevented.

In addition, the coupling upper covering parts140may include a plurality of sixth holes144, and the bone fusion may be enhanced as blood flows through the sixth holes144.

The side bending part150, which is downwardly bent from the coupling part120to be curved, may cover a side of the alveolar bone. The side bending part150after bending has an overall curved shape with a gentle slope. The side bending part150includes a plurality of first holes153with a predetermined size. The first holes153are used as pathways for blood to flow as mentioned above.

The side bending part150includes a first bending part151that may be bent in a direction away from the coupling part120and a second bending part152bending in a direction towards the coupling part120. Here, the first bending part151may include the first holes153with a diameter in a range of about 0.9 mm to about 2.0 mm, and the second bending part152may include seventh holes154with a diameter smaller than that of the first holes153of the first bending part151. Here, the first holes153at the lowermost part of the first bending part151may be aligned along a concave line Ir of a “C” shape. In this regard, the first holes153are aligned in a “C” shape to spontaneously form a bending line as the concave line Ir, and thus localized protrusion at some regions during a bending process may be prevented. Also, a size of the seventh holes154of the second bending part152is relatively small to maximize the flexibility of the side bending part150during the bending process, so that the side bending part150may be bent to be curved even when a radius of curvature is large.

The lateral covering parts160, in which the bone graft material82may be provided, is formed to protrude from a lateral portion of the side bending part150and may be bent toward the bone graft material82to be curved. The lateral covering parts160include a plurality of second holes161. The lateral covering parts160cover a buccal side of the bone defect area and may have a shape having a distance between the side bending part150gradually increasing from an upper portion to a lower portion of the lateral covering parts160and maintaining a constant distance between the side bending part150which after a midline of the lateral covering parts160. Each of the lateral covering parts160is made as a single unit throughout the entire lateral portion of the side bending part150so as that the lateral covering parts160may be conveniently removed from the bone defect area after the bone fusion. The plurality of second holes161are formed in the lateral covering parts160, and a diameter of the second holes161may be smaller than that of the first holes153. For example, a diameter of the first holes153may be in a range of about 0.9 mm to about 2.0 mm, and a diameter of the second holes161may be in a range of about 0.1 mm to about 0.5 mm. Here, the second holes161may be more tightly arranged than the first holes153, thus a greater number of holes may be formed in the lateral covering parts160per the same unit area. That is, a total hole area of the second holes161per unit area of the lateral covering parts160may be larger than a total hole area of the first holes153per unit area of the side bending part150.

In this regard, as the second holes161are tightly arranged with a small diameter, the overall flexibility of the lateral covering parts160increases, and thus the membrane for alveolar bone regeneration100may be conveniently removed from the alveolar bone81without damaging nearby gingiva after completion of the alveolar bone regeneration. Also, as the lateral covering parts160are flexible, the bending may be conveniently performed.

The lower covering parts170protrude downward from a lower portion of the side bending part150. The lower covering parts170include a plurality of third holes173. A diameter of the third holes173may be smaller than that of the first holes153. For example, a diameter of the first holes153may be in a range from about 0.9 mm to about 2.0 mm, and a diameter of the third holes173may be in a range from about 0.6 mm to about 0.8 mm. Accordingly, the lower covering parts170may obtain sufficient flexibility, and thus the lower covering parts170may be removed from the alveolar bone81after a subsequent bone fusion.

The lower covering parts170may include a concave groove174that is concave in a direction toward the body parts, and if the largest protrusion height of the lower covering parts170, which are also the protruding parts, is referred to as h3and the largest depth of the concave groove174is referred as h4, the largest protrusion height h3is greater than the largest depth h4. In addition, a pair of bending lines may be separated from each other on the lower covering parts170, which are also the protruding parts. Here, among the bending lines, one bending line13may be formed at a borderline of the side bending part150, which is one of the body parts, and the lower covering parts170, which are also the protruding parts, and the other bending line l4may be formed to meet a bottom of the concave groove174.

Here, the bending line13may connect a pair of third bending points (not shown) where the side bending part150and the lower covering parts170meet, and the other bending line l4may be separately located above the third bending points and passes an bottom point (not shown) of the concave groove174. Here, the bending line l3may be located above and parallel to the bending line l4, but is not limited there to, and the bending line l3may be separated unparallel to the bending line l4.

Here, the lower covering parts170include a first lower covering part171and second lower covering parts172, wherein the first lower covering part171extends continuously along both of the lower covering parts170, and the second lower covering parts172are both protruded from the first lower covering part171to be bent individually. As the bending lines l.sub.3 and l.sub.4 separated from each other, an overall bending line may have a gentle slope, and thus a local protruding phenomenon may be prevented. That is, when there is only one bending line, the lower covering parts170may be curved at a steep angle, thus a crumpling phenomenon around the bending line may excessively occur. However, when there are two or more bending lines as described in the current embodiment of the present invention, the lower covering parts170may be curved at a relatively shallow angle, thus localized stress concentration may hardly occur, and accordingly, the drastic crumpling phenomenon at some regions may be prevented.

In addition, a surface of the membrane for alveolar bone regeneration100may be coated with a tin-coating layer, anodized, or heat-treated to realize various colors. Here, when the surface of the membrane for alveolar bone regeneration100is anodized, the surface of the membrane for alveolar bone regeneration100may realize various surface colors by changing an applied voltage. Also, when the surface of the membrane for alveolar bone regeneration100is heat-treated, various colors, such as a gold color, may be realized according to a heat-treating temperature. In this regard, the membrane for alveolar bone regeneration100may be realized with various colors when the surface is coated with a tin-coating layer, anodized, or heat-treated, and thus, an overall aesthetic sense may be improved. Moreover, as shown inFIGS. 2 and 3, the membrane for alveolar bone regeneration100may be pre-formed in a three-dimensional stereoscopic curve shape in a direction of the alveolar bone81as to fit a final shape of an alveolar bone to be regenerated.

The membrane for alveolar bone regeneration100according to the current embodiment of the present invention has the following effects.

First, before attaching the membrane for alveolar bone regeneration100, the implant80is inserted to the alveolar bone81, and the bone graft material82is filled in the bone defect area. Then, the membrane for alveolar bone regeneration100pre-formed by a three-dimensionally forming process for the implant80is coupled to the implant80. In particular, the pre-formed membrane for alveolar bone regeneration100is coupled to the implant80by screwing the implant80through the central hole121of the coupling part120. After the membrane for alveolar bone regeneration100is fix-coupled in the manner described above, the defect area is adapted to gingiva. Then, a predetermined time passes for the bone graft material82to be bone fused to the membrane for alveolar bone regeneration100. Thus, after the alveolar bone is regenerated, the membrane for alveolar bone regeneration100is removed from the bone defect area.

An overall bending line of the membrane for alveolar bone regeneration100according to an embodiment of the present invention may have a gentle slope as the pair of bending lines l3and l4, which are separated from each other, are formed on the lower covering parts170, and thus a crumpling phenomenon may be prevented. For example, as shown inFIGS. 2 and 3, the pair of bending lines l3and l4of the lower covering parts170may prevent the crumpling phenomenon (occurrence), may enable complete adhesion of the membrane for alveolar bone regeneration100to the bone graft material82during a guiding period of the bone regeneration, and may serve as a stable guide, thus a risk of the membrane for alveolar bone regeneration100being exposed through the gingival may be minimized.

Moreover, the flexibility at a region where a steep curve is necessary may be increased by varying the sizes of the holes for each region, and thus bendability may be maximized. Accordingly, a field usability at the operation field may be increased even when local bending is necessary.

Also, as the lateral covering parts160are designed to have high flexibility, the membrane for alveolar bone regeneration100may be convenient to be later removed from a bone graft material, in addition to its bendability.

Moreover, the membrane for alveolar bone regeneration100may be pre-formed in a three-dimensional stereoscopic curve shape in a direction of the alveolar bone81as to fit a final shape of an alveolar bone to be regenerated by using a predetermined bending device, and accordingly, the crumpling phenomenon may be certainly prevented instead of forming a membrane at an instance.

A membrane for alveolar bone regeneration according to an embodiment may be modified as follows:

First, as shown inFIG. 5, a membrane for alveolar bone regeneration200may not have separate concave grooves in coupling upper covering parts240and lower covering parts270.

Other major parts of the membrane for alveolar bone regeneration200may have substantially the same structure as the membrane for alveolar bone regeneration100shown inFIGS. 1 through 4.

Also, as shown inFIG. 6, separate holes may not be formed in a second bending part352and lower covering parts370. In this regard, a membrane for alveolar bone regeneration300may be conveniently as separate holes are not formed in the second bending part352and the lower covering parts370. For example, when separate holes are not formed in the second bending part352and the lower covering parts370, blood may not flow through, and accordingly, linkage tissue due to the blood flow may not be provided, and thus the membrane for alveolar bone regeneration300may be conveniently removed from the bone graft material later.

Moreover, as shown inFIG. 7, separate holes may not be formed in a second bending part452and a lower covering part470of a membrane for alveolar bone regeneration400. Although an overall structure of the membrane for alveolar bone regeneration400is substantially the same as the membrane for alveolar bone regeneration200shown inFIG. 5, the membrane for alveolar bone regeneration400may be conveniently removed as separate holes are not formed in the second bending part452and the lower covering part470.

Also, as shown inFIG. 8, separate coupling upper covering parts may not be provided. That is, unlike the membrane for alveolar bone regeneration100shown inFIGS. 1 through 4, a membrane for alveolar bone regeneration500ofFIG. 8, where separate coupling upper covering parts140are not provided, may be used when there is no defect on a side where the tongue is located but the defect is on the side of the lips and peripheral teeth.

Also, as shown inFIG. 9, separate holes may not be formed in a second bending part652and lower covering parts670. Although an overall structure of a membrane for alveolar bone regeneration600is substantially the same as the membrane for alveolar bone regeneration500shown inFIG. 5, the membrane for alveolar bone regeneration600may be conveniently removed as separate holes are not formed in the second bending part652and the lower covering parts670.

Also, as shown inFIG. 10, separate coupling upper covering parts may not be provided. Although an overall structure is substantially the same as the membrane for alveolar bone regeneration200shown inFIG. 5, a membrane for alveolar bone regeneration700, where separate coupling upper covering parts are not provided, may be used when there is no defect on a side where the tongue is located but the defect is on the side of the lips and peripheral teeth.

Also, as shown inFIG. 11, separate holes may not be formed in a second bending part852and lower covering parts870. Although an overall structure is substantially the same as the membrane for alveolar bone regeneration700shown inFIG. 10, linkage tissue is not formed at the corresponding area when separate holes are not formed in the second bending part852and the lower covering parts870, and thus, the membrane for alveolar bone regeneration800may be conveniently removed.

Also, as shown inFIG. 12, the membrane for alveolar bone regeneration100may be structured without the coupling lateral covering parts130and the coupling upper covering parts140. In this regard, a membrane for alveolar bone regeneration900that is not provided with coupling lateral covering parts and coupling upper covering parts may be used when there is no defect on a side where the tongue and peripheral teeth are located but the defect is on the side of the lips only.

Also, as shown inFIG. 13, separate holes may not be formed in a second bending part1052and lower covering parts1070. In this regard, a membrane for alveolar bone regeneration1000where holes are not formed in a certain area may not form linkage tissue at the corresponding area, and thus, the membrane for alveolar bone regeneration1000may be conveniently removed.

Also, as shown inFIG. 14, a lower covering part1170may be formed as one. Although an overall structure is substantially the same as the membrane for alveolar bone regeneration1000shown inFIG. 13, an area that may be covered by a membrane may increase if the lower covering part1170is formed as one.

Also, as shown inFIG. 15, separate holes may not be formed in a second bending part1252and a lower covering part1270. Although an overall structure is substantially the same as the membrane for alveolar bone regeneration1110shown inFIG. 14, a membrane for alveolar bone regeneration1210may be conveniently removed as linkage tissue is not formed at the corresponding area when separate holes are not formed in the second bending part1252and the lower covering part1270.