Use, in cosmetic preparations, of prostaglandin EP-3 receptor agonists to attenuate, reduce or stop the growth of head hair and other hairs

The present invention relates to a use of prostaglandin E2 (EP-3) receptor agonists to attenuate, reduce or stop the growth of head hair and other hairs, in cosmetic preparations, and to the cosmetic treatment process using these compositions.

EXAMPLES OF LOTIONS FOR PREVENTING HAIR GROWTH 
 Example I 1 Sulprostone 0.3 g Propylene glycol 20 g 95° ethanol 30 g Water qs 100 g This lotion is applied daily at a rate of 10 ml to the scalp, for 2 to 3 months. A marked reduction in the daily growth of head hair and other hairs is then observed. 
 Example II 2 TEI 3356 0.15 g Polyglyceryl 3-hydroxylauryl ether 26 g A.M. Hydroxypropylcellulose sold under the name Klucell G by the company Hercules 2 g Preserving agent qs 95° ethanol 50 g Water qs 100 g This lotion is used daily at a rate of 15 g per head of hair, with an exposure time of about one minute, for a period of 4 months. An appreciable reduction in the daily growth of the hair is then observed. 
 Example III 3 M&B-28767 0.03 g Propylene glycol 20 g 95° ethanol 30 g Water qs 100 g This lotion is applied daily at a rate of 10 ml to the scalp, for 2 to 3 months. A marked reduction in the daily growth of head hair and other hairs is then observed. 
 Example IV 4 Prostaglandin PGE1 0.015 g Polyglyceryl 3-hydroxylauryl ether 26 g A.M. Hydroxypropylcellulose sold under the name Klucell G by the company Hercules 2 g Preserving agent qs AH23848B 1 g 95° ethanol 50 g Water qs 100 g This lotion is used daily at a rate of 15 g per head of hair, with an exposure time of about one minute, for a period of 4 months. An appreciable reduction in the daily growth of the hair is then observed. Experiment: In order to study the behaviour of hair follicles in the presence of a prostaglandin EP-3 receptor agonist, the Applicant used the “surviving hair” method from L'Oreal Patent FR 9508465. From a scalp biopsy, a fairly thin strip of scalp was isolated using a scalpel. With microtweezers, the adipose tissue around the follicles was removed, while taking care not to damage the hair bulb. Under a microscope, the follicle was cut away using a scalpel to separate it from its epidermal and dermal environment. One of the fragments obtained was cultured in Williams E medium at 37° C. under a humid atmosphere in the presence of 5% CO 2 and was used as control. The other fragments were placed in the same culture medium in the presence of a prostaglandin EP-3 receptor agonist: sulprostone, compound TEI3356, compound M&B-28767, prostaglandin PGE1. The fragments in the presence of the agonists thus maintained in histoculture shorten in a significantly greater manner in comparison with the agonist-free control fragment.