Reading device and method for measuring energy and flight time using silicon photomultipliers

This invention is about a readout apparatus and method for time-of-flight and energy measurements with silicon photomultipliers (SIPM) coupled to a scintillator. The timing measurement can be as accurate as 50 ps or below, after calibration. The energy is measured using a time-over-threshold technique, and the energy resolution is only constrained by the scintillation statistics. In order to achieve low power of 10 mW per channel, a low impedance input amplifier and analog time-to-digital converters (TDCs) based on time interpolation are used. The readout circuit can be triggered by a single photoelectron (p.e.) with a signal-to-noise ratio (SNR) above 20 dB. The said readout circuit operates with SiPMs of different gain, polarity and matrix size. The preferred embodiment of the readout apparatus is a multi-channel application specific integrated circuit (ASIC) with 64 channels.

BACKGROUND OF THE INVENTION

Time-of-flight information on PET systems (TOFPET) allows for unprecedented sensitivity, as the signal-to-noise ratio and thus the background rejection are very much improved. The very high gain of the silicon multiplier (SiPM) and its sensitivity to single photon hits makes it a good candidate for highly compact systems. A timing resolution of 200 ps is enough to confine the event origin with a FWHM position uncertainty of 30 mm along the line-of-response (LOR). Achieving this fine resolution calls for fast front-end electronics, capable of extracting a very precise time stamp of each event. Scintillation light statistics, which include intrinsic timing characteristics of the crystal and the travel path of the photons, along with the time drift inherent to the e-h pair generation of the SIPM, may become a source of jitter that could ultimately compromise the targeted time resolution. In fact, the signal shape fluctuation at the output of the photodetector reflects the statistical time distribution of each photon building up the signal. Since the arrival time of these photons is weakly correlated to the time of the electron-positron annihilation, the readout system must be able to trigger on the first photo-electron. This ability requires low-noise front-end electronics with enough bandwidth such that the time walk across the dynamic range becomes negligible.

On the other hand, the design of compact PET detectors poses strict limits on power consumption. This constraint has motivated the choice of a low-power input stage and a very low-power analogue time-to-digital converter with a time binning of 50 ps.

DESCRIPTION OF THE PREFERRED EMBODIMENT

The present invention, described below with a preferred embodiment, refers to a readout apparatus for time-of-flight and energy measurements characterized by using silicon photomultipliers (SiPM), providing accurate time-of-flight information when used in PET systems with fast crystals (e.g. LYSO), which allow to confine the origin of the two 511 keV photons with a position uncertainty of 30 mm along the line-of-response (LOR) and permit unprecedented PET sensitivity.

The preferred embodiment of the readout architecture described is an ASIC made up of 64 channels, bias and calibration blocks and a global controller. One edge is free of pins, such that a twin chip rotated by 180° can be abutted to build a compact 128 channel circuit (cf.FIG. 4). Nominal operation mode uses a 160 MHz clock generated off-chip. Up to two LVDS data output links are available (SDR or DDR), for a total bandwidth from 160 to 640 Mbit/s.

An output clock for synchronous transmission is available, while a TX training mode can also be used to avoid it. Event data is processed on-chip and output in frames with up to 64 events per frame. A raw data mode (safe-mode) is also available, in which event data is output with no arithmetic processing (thereby taking two “slots”). A 10 MHz SPI configuration interface writes and reads the channel configuration, controls calibration procedures and test modes. The clock, reset and coarse time counter is internally propagated by the global controller to each channel, along with the configuration settings.