Automatic biochemical analyzer

There is disclosed an automatic biochemical analyzer having a sample turntable and a reaction turntable. Plural sample containers for holding samples are arrayed on the sample turntable. Plural reaction containers are arrayed on the reaction turntable. A sampling pipette draws in a sample from some sampling container and injects the sample into some reaction container. A reagent pipette draws in some reagent from some reagent container and injects the reagent into the same reaction container. The resulting mixture is stirred by a stirring device. Produced reaction products are detected by a detector. Let N be the number of the reaction containers on the reaction turntable. The reaction turntable is rotated in M pitches in one step. Note that M and N do not have any common factor. First and second injecting positions adjacent to each other are established as positions where the reagent pipette can inject a reagent into the reaction container in position. First and second stirring positions adjacent to each other are established as positions where the stirring device can stir liquids in the reaction container in position. The stirring device can be moved between the first and second stirring positions. Thus, one reagent pipette can be used for two kinds of reagents. Also, one stirring device can be used for two kinds of reagents.

FIELD OF THE INVENTION 
The present invention relates to an automatic biochemical analyzer for 
analyzing biological samples such as blood and urine in terms of plural 
items. 
BACKGROUND OF THE INVENTION 
Such automatic biochemical analyzers for analyzing biological samples have 
been known, as proposed in Japanese Patent Laid-Open No. 2024/1993. In 
this prior art technique, a plurality of sample containers are set on a 
sample disk. In this instrument, aliquots of sample in the sample 
containers set on the sample disk are drawn in by a sample pipette and 
dispensed into reaction containers on a reaction disk. A reagent pipette 
draws in reagents from plural reagent disks and adds the reagents to the 
aliquots of sample. Thus, the sample is analyzed in terms of plural items. 
During the analysis, the order in which the items are analyzed is 
determined, taking account of the time required for the processing, in 
order to shorten this processing time. 
In this automatic biochemical analyzer, plural kinds (e.g., four kinds) of 
reagents are successively added to a biological sample in each reaction 
container on the reaction turntable. The induced reactions are optically 
detected. The added reagents are referred to first through fourth 
reagents, respectively, according to the order in which they are added. 
Whenever each kind of reagent is put into a reaction container, it is 
necessary to stir the mixture inside the container. 
Providing a reagent pipette and a stirring device for each different kind 
of reagent may also be conceivable. That is, four sets of reagent pipettes 
and stirring devices corresponding to the first through fourth reagents 
are arranged around the reaction turntable. However, the sample pipette 
for pipetting the sample into the reaction containers, a washing device 
for washing the sample pipette, a detector, a washing device for washing 
the reaction containers, and so on are disposed around the reaction 
turntable. Therefore, limitations are imposed on the space where those 
reagent pipettes and stirring devices are installed. Consequently, it is 
very difficult to dispose as many as four sets of reagent pipettes and 
stirring devices around the reaction turntable. 
SUMMARY OF THE INVENTION 
In view of the foregoing circumstances, the present invention has been 
made. 
It is an object of the present invention to provide an automatic 
biochemical analyzer equipped with less reagent pipettes and less stirring 
devices. 
This object is achieved in accordance with the teachings of he invention by 
an automatic biochemical analyzer comprising: a sample turntable on which 
a plurality of sample containers for holding samples are arrayed; a 
reaction turntable on which a plurality of reaction containers for holding 
reagents are substantially regularly spaced from each other by one pitch 
circumferentially; a sampling pipette for drawing in an aliquot of sample 
from a selected one of said sample containers and injecting the drawn 
aliquot of sample into a selected one of the reaction containers; a 
reagent pipette for drawing in an aliquot of a selected one of said 
reagents and injecting the drawn aliquot of reagent into said selected 
reaction container at any one of first and second injecting positions 
adjacent to each other; a stirring device for stirring said sample aliquot 
and said reagent aliquot in said selected reaction container at any one of 
first and second stirring positions adjacent to each other; and a detector 
for detecting reaction products arising from said sample aliquot after the 
stirring. Let N be the number of the sample containers on the reaction 
turntable. The reaction turntable is rotated in M pitches in one step. The 
M and N are so selected that they do not have any common factor. The 
stirring device is capable of moving between said first and second 
stirring positions. 
Other objects and features of the invention will appear in the course of 
the description thereof, which follows.

DETAILED DESCRIPTION OF THE INVENTION 
The whole structure of an automatic biochemical analyzer in accordance with 
the present invention is shown in FIG. 1. The biochemical analyzer, 
generally indicated by reference numeral 1, comprises a sample turntable 
4, a diluting turntable 6, a first reagent turntable 8, a second reagent 
turntable 10, and a reaction turntable 12. A given number of sample 
containers 2 holding biological samples are set on the sample turntable 4. 
The samples are drawn from the sample containers 2 and diluted. The 
diluted samples are put in diluting containers 5, which in turn are set on 
the diluting turntable 6. Reagent containers 7 holding first and fourth 
reagents of different kinds are set on the reagent turntable 8. Reagent 
containers 9 holding second and third reagents of different kinds are set 
on the second reagent turntable 10. A given number of reaction containers 
11 are set on the reaction turntable 12. 
On the sample turntable 4, the sample containers 2 are arranged in two rows 
and regularly spaced from each other by one pitch. Each row consists of 42 
sample containers 2. This sample turntable 4 is rotated incrementally, one 
pitch at a time. 
A diluting pipette 13 is mounted between the sample turntable 4 and the 
diluting turntable 6 and reciprocated between the sample turntable 4 and 
the diluting turntable 6 by a drive mechanism (not shown). The diluting 
pipette 13 is moved up and down for aspirating and injecting operations. 
When the diluting pipette 13 gains access to one sample container 2 in a 
given location on the sample turntable 4, a sampling pump (not shown) is 
operated to take in a given amount of sample. Then, the diluting pipette 
13 obtains access to one diluting container 5 in a given position on the 
diluting turntable 6. A given amount of diluent (normally physiological 
salt solution) supplied from the diluting pipette 13 itself is injected 
into the diluting container 5, along with the sample. As a result, the 
sample is diluted by a given factor within the diluting container 5. 
Thereafter, the diluting pipette 13 is washed by a washing device (not 
shown) located at the midway location in the reciprocating stroke of the 
pipette. 
A sampling pipette 14, a stirring device 15, and a washing device 16 are 
mounted around the diluting turntable 6, as well as the diluting pipette 
13. The diluted sample in the diluting container 5 is stirred by the 
stirring device 15, thus producing a uniform diluted sample. Let N be the 
number of the diluting containers 5 circumferentially arranged on the 
diluting turntable 6. The diluting turntable 6 is rotated incrementally, M 
pitches at a time. To arrange these devices 13, 14, 15, and 16 with 
sufficient degrees of freedom, M and N are so selected as not to have any 
common factor. 
A drive mechanism (not shown) reciprocates the sampling pipette 14 between 
the diluting turntable 6 and the reaction turntable 12 through the 
dilution washing device 16. When the sampling pipette 14 is lowered to 
gain access to one diluting container 5 in a given position on the 
diluting turntable 6, a diluting sampling pump (not shown) is operated to 
drawn in a given amount of diluted sample. Then, the sampling pipette 14 
is lowered to obtain access to one reaction container 11 in a given 
position on the reaction turntable 12, and the pipette 14 injects the 
drawn diluted sample into the reaction container 11. 
The stirring device 15 is moved up and down by a vertical driving mechanism 
(not shown) and has a stirring rod (not shown) reciprocating diametrically 
of the diluting turntable 6. The stirring rod of the diluting turntable 6 
advances into a diluted sample in the diluting container 5 and moves back 
and forth to produce a uniform diluted sample. The washing device 16 
cleanses the sampling pipette 14 after the diluted sample is injected into 
the reaction container 11. 
Disposed around the reaction turntable 12 are reagent pipettes 17, 18, 
stirring devices 19, 20, a multi-wavelength photometer 21 acting as a 
detector, a thermostatic chamber 22, and a washing device 23 for washing 
the reaction container, as well as the sampling pipette 14. These devices 
operate at their respective positions relative to the reaction container 
11. 
Referring to FIG. 2, it is assumed that 221 reaction containers 11 are 
disposed along the whole outer periphery of the reaction turntable 12. 
Numerals 1 through 221 are given to 221 positions taken in a 
counterclockwise direction along the outer surface of the reaction 
turntable 12. A first reagent is injected at position 1. A fourth reagent 
is injected at position 2. The first reagent is stirred at position 4. The 
fourth reagent is stirred at position 5. A third reagent is injected at 
position 36. A second reagent is injected at position 37. The third 
reagent is stirred at position 39. The second reagent is stirred at 
position 40. The reaction container 11 is washed and checked for 
contamination at positions 80-107. A diluted sample is injected at 
position 113. The pipettes 14, 17, 18, the stirring devices 19, 20, and 
the washing device 23 perform their operations on the reaction container 
11 halted at the positions described above. 
The reagent pipette 17 is reciprocated between the reaction turntable 12 
and the reagent turntable 8 by a driving mechanism (not shown). When the 
first reagent should be pipetted into the reaction container 11, the 
reagent pipette 17 is lowered and obtains access to the reagent container 
7 located at a given position on the reagent turntable 8. Then, a reagent 
pump (not shown) is operated to draw in a given amount of reagent. 
Thereafter, the pipette rotates toward the reaction turntable 12. The 
pipette is lowered to get access to the reaction container 11 positioned 
at a given location on the reaction turntable 12. The drawn reagent is 
injected as the first reagent into the reaction container 11. 
The reagent pipette 17 operates similarly when the fourth reagent held in 
other reagent container 7 is pipetted into the reaction container 11. As 
mentioned previously, the position at which the fourth reagent is pipetted 
differs from the position at which the first reagent is pipetted. That is, 
the reagent pipette 17 is designed so that it can come to a halt at two 
pipetting positions. 
The stirring device 19 is moved up and down by a driving mechanism (not 
shown) and has a stirring rod (not shown) that is rotated and moved back 
and forth. The stirring rod is advanced into the reaction container 11 in 
a given position on the reaction turntable 12 and then rotated and moved 
back and forth diametrically of the reaction turntable 12. This assures 
that the first reagent induces a uniform reaction of the diluted sample. 
The stirring device 19 similarly stirs the diluted sample and the fourth 
reagent inside the reaction container 11. As described above, the position 
at which the fourth reagent is stirred is different from the position at 
which the first reagent is stirred. 
The reagent pipette 18 draws the second or third reagent from the second 
reagent turntable 10 and injects the drawn reagent into the reaction 
container located in a given position on the reaction turntable, in 
exactly the same way as the reagent pipette 17. The stirring device 20 
stirs the second or third reagent and the diluted sample in the reaction 
container, in exactly the same manner as the stirring device 19. 
The multi-wavelength photometer 21 measures the absorbance of the diluted 
sample inside the reaction container 11 and detects the reaction products 
arising from the diluted sample in the reaction container 11. 
The thermostatic chamber 22 maintains constant the temperature of the 
reaction containers 11 on the reaction turntable 12 at all times. 
The washing device 23 uses a draining pump (not shown) to draw in the 
detected diluted sample and reagent held in the reaction container 11. The 
drawn sample and reagent are discharged into a draining tank. Then, a 
detergent pump (not shown) supplies a detergent into this reaction 
container 11 to wash the interior of the reaction container 11. The 
detergent is then drawn off into the draining tank. At this time, the 
degree of contamination of the reaction container 11 is measured. If it is 
heavily contaminated, a warning is issued to replace the container. 
Let N be the number of the reaction containers 11 circumferentially 
arranged on the reaction turntable 12. This reaction turntable 12 is 
rotated incrementally, M pitches at a time. To arrange these devices 14, 
17, 18, 19, 20, 21, 22, and 23 with sufficient degrees of freedom, M and N 
are so selected as not to have any common factor. The reaction turntable 
12 is rotated through more than 180 degrees in one step. In the present 
embodiment, the 221 reaction containers 11 are rotated in 112 pitches in 
one step. 
Suppose that one reaction container is halted at position 1. This container 
is rotated in 112 pitches in the next one step and reaches position 113. 
The container is rotated in 112 pitches in the next one step and arrives 
at position 4. In summary, after incremental movements in two steps, the 
container has been moved in 3 pitches. 
FIG. 3 is a fragmentary schematic enlarged view of the reagent pipette 17 
and the stirring device 19 of the analyzer shown in FIG. 1. The reagent 
pipette 17 is rotated along a trajectory indicated by an arc in FIG. 3. 
This pipette 17 can be halted either at position 1 or at position 2 by 
selecting the angle through which the pipette rotates at a time. In 
position 1, the reagent pipette 17 can pipette a first reagent into the 
reaction container 11. In position 2, the reagent pipette 17 can inject a 
fourth reagent into the reaction container 11. 
On the other hand, the stirring device 19 can move one pitch (i.e., the 
distance between the successive reaction containers 11) straightly between 
positions 4 and 5 along a straight line tangent to the outer surface of 
the reaction turntable 12. The stirring device 19 may also move in a 
slightly curved path along the outer surface of the reaction turntable 12. 
The reagent pipette 18 and stirring device 20 that are put in parentheses 
in FIG. 3 are constructed similarly to the reagent pipette 17 and stirring 
device 19, respectively, shown in FIG. 3. 
The present example of reagent-injecting-and-stirring device constructed in 
this way performs various operations on one reaction container at the 
timing illustrated in Table I. As the reaction turntable 12 is rotated in 
one step, each reaction container 11 is rotated in M pitches (e.g., 112 
pitches). M does not have any common factor with the total number, or 221, 
of the reaction containers 11. Furthermore, M is in excess of half of the 
total number. Whenever the reaction turntable 12 rotates in one step, the 
turntable rotates in 112 pitches and comes to a halt. This series of 
operations is repeated at intervals of 3 seconds, as shown in FIG. 5(a). 
During the former half of the 3-second period, the reaction turntable is 
rotated. During the latter half, the turntable is halted, and a set of 
operations is performed. One sequence of operations is completed in 221 
steps in 3 seconds.times.221. 
In Table I, some steps (e.g., steps 1, 2, and 3) each have an upper column 
and a lower column. The upper column indicates a position assumed before 
rotation, while the lower column indicates a position taken after 
rotation. The remaining steps each have one column indicating a position 
taken before rotation. 
In Table I, in step 1, some reaction container 11A comes to a halt at 
position 1 after rotation of the reaction turntable. The reagent pipette 
17 gains access to this reaction container 11A. A first reagent previously 
aspirated is injected into the container 11A (R1) (see FIG. 3). At this 
time, any diluted sample is not yet injected into the reaction container 
11A. 
In step 2, the reaction turntable 12 rotates in 112 pitches. The reaction 
container 11A into which the first reagent was pipetted at position 1 is 
halted at a diluted sample-injecting position 113. 
The sampling pipette 14 gets access to the reaction container 11A and 
pipettes a diluted sample into the reaction container 11A (S). In 
particular, a nozzle (not shown) mounted at the front end of the sampling 
pipette 14 is advanced into the first reagent. Under this condition, the 
diluted sample is injected into the first reagent. Then, the nozzle is 
withdrawn from the first reagent. At this time, a slight amount of the 
first reagent adheres to the outer surface of the nozzle at the front end. 
Since the amount of the first reagent is greater than the amount of the 
diluted sample, the adhesion of the first reagent hardly affects the 
reaction of the diluted sample with the first reagent. 
In step 3, the reaction turntable 12 is rotated in 112 pitches and comes to 
a halt. During the rotation, the reaction container 11A passes in front of 
the multi-wavelength photometer 21, which in turn measures the absorbance 
of the mixture of the diluted sample and the reagent inside the reaction 
container 11A. Whenever the reaction container 11A subsequently passes in 
front of the photometer 21 during rotation of the reaction turntable in 
this way, the photometer 21 performs a similar measurement. 
During this halt, the reaction container 11A arrives at a first stirring 
position 4 (FIG. 3). The stirring device 19 stirs the diluted sample and 
the first reagent in the reaction container 11A (R1MIX). The stirring rod 
of the stirring device 19 is lowered into the diluted sample and first 
reagent in the container 11A. The stirring rod is rotated and reciprocated 
back and forth diametrically of the reaction turntable 12. The rotation 
and reciprocating movement of the stirring rod, done longitudinally of the 
reaction container, make the stirring operation efficient. 
In step 4, the reaction turntable 12 is rotated in 112 pitches and comes to 
a halt. The reaction container 11A having the first reagent already 
stirred in step 3 is at position 116. At this time, the reaction container 
11A is not processed at all. In this way, the reaction turntable 12 is 
rotated in 112 pitches, brought to a halt, and stirring is done in a 
sequence of steps in 3 seconds, for example. This sequence of steps is 
repeated at regular intervals. 
In step 25, the reaction turntable 12 comes to a halt, and the reaction 
container 11A arrives at a second reagent-injecting position 37 (FIG. 3). 
The reagent pipette 18 injects the second reagent in the same way as the 
injection of the first reagent (R2). 
In step 27, the reaction turntable 12 comes to a halt, and the reaction 
container 11A comes to a halt at the second stirring position 40. The 
stirring device (20) stirs the second reagent (R2MIX) in the same way as 
the stirring (R1MIX) of the first reagent by the stirring device 19. 
In step 98, the reaction turntable 12 comes to a halt, and the reaction 
container 11A arrives at a third reagent-injecting position (36). Since 
this third reagent-injecting position (36) is adjacent to the second 
reagent-injecting position (37), the reagent pipette (18) is rotated to 
this third reagent-injecting position, and then the reagent pipette (18) 
(R3) injects the third reagent. 
In step 100, the reaction turntable 12 comes to a halt, and the reaction 
container 11A reaches a third stirring position (39) adjacent to the 
second stirring position (40). The stirring device (20) is rotated in one 
pitch up to the third stirring position along a straight line tangent to 
the outer surface of the reaction turntable 12. At this location, the 
stirring device 20 stirs the third reagent (R3MIX). 
In step 149, the reaction turntable 12 comes to a halt, and the reaction 
container 11A reaches a fourth reagent-injecting position 2 (FIG. 3) 
adjacent to the first reagent-injecting position 1. The reagent pipette 17 
is rotated to this fourth reagent-injecting position and then injects the 
fourth reagent (R4). 
In step 151, the reaction turntable 12 comes to a halt, and the reaction 
container 11A arrives at the fourth stirring position 5 adjacent to the 
first stirring position 4. The stirring device 19 is moved one pitch 
straight along the straight line tangent to the outer surface of the 
reaction turntable 12 and assumes a state indicated by the phantom lines 
in FIG. 2. Then, the stirring device 19 can stir the fourth reagent 
(R4MIX). 
As mentioned previously, whenever the reaction container 11A passes in 
front of the multi-wavelength photometer 21 during rotation of the 
reaction turntable 12, the photometer 21 detects reaction products arising 
from the diluted sample in response to each reagent. These measurements 
end before step 201. Then, the reaction container 11A used for 
measurements is washed. More specifically, a cleaning device 23 washes the 
reaction container 11A (WD1, WD2, WD3, WD4, WD5, and WD6), using an 
alkaline detergent, an acidic detergent, or pure water, at positions 80, 
83, 86, 89, 92, and 95, respectively, in steps 201, 203, 205, 207, 209, 
and 211, respectively. 
In steps 214 and 216, the degree of contamination of each reaction 
container 11 is measured, using physiological salt solution at positions 
98 and 101, respectively. Finally, in steps 217 and 219, the cleaning 
device 23 discharges liquid from the reaction container 11 at positions 
104 and 107, respectively. In this way, the measurement of the sample in 
one reaction container 11A is completed. In practice, reaction containers 
successively moved into position 1 subsequently to the reaction container 
11A are treated similarly at intervals of one step. 
In this way, in the present invention, the reaction turntable 12 is rotated 
in 112 pitches in one step. It is to be noted that 112 does not have any 
common factor with the total number, or 221, of the reaction containers 
11. This increases the degrees of freedom in designing the instrument. As 
a result, the two positions at which two kinds of reagents are pipetted or 
stirred can be made adjacent to each other around the reaction turntable. 
Consequently, four kinds of reagents can be pipetted and stirred by two 
reagent pipettes and two stirring devices. Hence, the instrument can be 
made up of less number of components than heretofore. Also, the cost can 
be curtailed. 
Table II illustrates an example of timing of a sequence of operations 
performed on one reaction container in the same manner as in the example 
of Table I. The turntable is rotated in 112 pitches in one step similarly 
to the example of Table I but the period of the 112 pitches is divided 
into a former operative period corresponding to earlier 45 pitches and a 
latter operative period corresponding to latter 67 pitches. Two halt 
periods are placed between these two operative periods. An operation can 
be carried out during each halt period. The total period consisting of the 
two operative periods and the two halt periods is set, for example, to 4.5 
seconds. The control mechanism for operating the instrument at the timing 
illustrated in Table II is the same as the control mechanism of FIG. 1. 
In this embodiment, as the reaction turntable 12 is rotated one revolution 
in 221 steps, one reaction container 11 brought to a halt at position 1 in 
step 1 is again halted at position 1 in step 193. The reaction container 
11 halted at position 2 in step 119 is again brought to a halt at position 
2 in step 149. The reaction container 11 halted at position 4 in step 3 is 
again halted at position 4 in step 195. The reaction container 11 halted 
at position 5 in step 121 is again halted at position 5 in step 151. 
That is, while the reaction turntable 12 is being rotated in 221 steps, the 
same reaction container 11 is halted twice at the same position. 
Therefore, when the same reaction container 11 halts at position 1 twice 
and at position 2 twice, it is possible to pipette four kinds of reagents 
with one reagent pipette 17. Also, when the same reaction container 11 
halts at position 4 twice and at position 5 twice, four stirring steps can 
be performed with one stirring device 19. Similarly, four kinds of 
reagents can be pipetted with another reagent pipette 18. Also, four 
stirring steps can be carried out with another stirring device 20. 
Accordingly, in the present example of timing of injection and stirring of 
reagents, 8 kinds of reagents, in total, can be injected and stirred with 
two reagent pipettes 17, 18 and two stirring devices 19, 20. 
In this manner, more reagents can be injected and stirred with less reagent 
pipettes and less stirring devices by variously establishing the stepwise 
movements of the reaction turntable. This greatly increases the degrees of 
freedom in designing the instrument. This embodiment yields the same 
advantages as the above-described embodiment. 
Referring next to FIG. 4, there is shown another 
reagent-injecting-and-stirring device for use with an automatic 
biochemical analyzer. FIG. 4 is a fragmentary enlarged view similar to 
FIG. 3. 
In the embodiment shown in FIG. 3, the reagent pipette 17 is rotated so 
that it can inject aliquots of reagent into reaction containers 11 either 
at position 1 or at position 2. The stirring device 19 is linearly moved 
one pitch back and forth so that it can stir the liquid either at position 
4 or at position 5. In the embodiment shown in FIG. 4, the reagent pipette 
17 is rotated so that it can inject aliquots of reagent into the reaction 
containers 11 only at one position 1 or 2. However, the reagent pipette 17 
can linearly move one pitch back and forth along the tangential line to 
the outer surface of the reaction turntable 12. In the embodiment shown in 
FIG. 4, the first reagent pipette 17 and the first reaction stirring 
device 19 are held to a common support base 24. Therefore, the reagent 
pipette 17 or 18 can move one pitch back and forth, together with the 
stirring device 19 or 20. The configuration of FIG. 4 can be applied to 
any timing scheme of reagent injection and stirring illustrated in Table 
I. 
As can be understood from the description provided thus far, in an 
automatic biochemical analyzer in accordance with the present invention, 
the reaction turntable is rotated in M pitches in one step, it being noted 
that M and N (the total number of reaction containers on the reaction 
turntable) do not have any common factor. Two adjacent positions can be 
established as first and second reagent-injecting positions where the 
reagent pipette can inject aliquots of reagent into reaction containers. 
Also, two adjacent positions can be established as first and second 
stirring positions where a stirring device can stir liquid in reaction 
containers. One reagent pipette is moved between these two established 
first and second injecting positions. One stirring device is moved between 
these two established first and second stirring positions. Consequently, 
it is possible to inject two kinds of reagents with only one reagent 
pipette and one stirring device. Thus, the number of the components of the 
instrument can be reduced. This can lead to a decrease in the cost. 
Furthermore, more kinds of reagents can be injected and stirred by dividing 
one stepwise movement into a former stepwise movement and a latter 
stepwise movement with at least one intervening halt period. 
TABLE I 
______________________________________ 
Step Time Pos. Job 
______________________________________ 
1 -3.0 110 
1 -3.0 1 R1INJECT 
2 0.0 1 
2 0.0 113 S 
3 3.0 113 
3 3.0 4 R1MIX 
4 6.0 4 
5 9.0 116 
6 12.0 7 
7 15.0 119 
8 18.0 10 
9 21.0 122 
10 24.0 13 
11 27.0 125 
12 30.0 16 
13 33.0 128 
14 36.0 19 
15 39.0 131 
16 42.0 22 
17 45.0 134 
18 48.0 25 
19 51.0 137 
20 54.0 28 
21 57.0 140 
22 60.0 31 
23 63.0 143 
24 66.0 34 
25 69.0 146 
25 69.0 37 R2INJECT 
26 72.0 37 
27 75.0 149 
27 75.0 40 R2MIX 
28 78.0 40 
29 81.0 152 
30 84.0 43 
31 87.0 155 
32 90.0 46 
33 93.0 158 
34 96.0 49 
35 99.0 161 
36 102.0 52 
37 105.0 164 
38 108.0 55 
39 111.0 167 
40 114.0 58 
41 117.0 170 
42 120.0 61 
43 123.0 173 
44 126.0 64 
45 129.0 176 
46 132.0 67 
47 135.0 179 
48 138.0 70 
49 141.0 182 
50 144.0 73 
51 147.0 185 
52 150.0 76 
53 153.0 188 
54 156.0 79 
55 159.0 191 
56 162.0 82 
57 165.0 194 
58 168.0 85 
59 171.0 197 
60 174.0 88 
61 177.0 200 
62 180.0 91 
63 183.0 203 
64 186.0 94 
65 189 206 
66 192.0 97 
67 195.0 209 
68 198.0 100 
69 201.0 212 
70 204.0 103 
71 207.0 215 
72 210.0 106 
73 213.0 218 
74 216.0 109 
75 219.0 221 
76 222.0 112 
77 225.0 3 
78 228.0 115 
79 231 6 
80 234.0 118 
81 237.0 9 
82 240.0 121 
83 243.0 12 
84 246.0 124 
85 249.0 15 
86 252.0 127 
87 255.0 18 
88 258.0 130 
89 261.0 21 
90 264.0 133 
91 267.0 24 
92 270.0 136 
93 273.0 27 
94 276.0 139 
95 279.0 30 
96 282.0 142 
97 285.0 33 
98 288.0 145 
98 288.0 36 R3INJECT 
99 291.0 36 
100 294 148 
100 294.0 39 R3MIX 
101 297.0 39 
102 300.0 151 
103 303.0 42 
104 306.0 154 
105 309.0 45 
106 312.0 157 
107 315.0 48 
108 318.0 160 
109 321.0 51 
110 324.0 163 
111 327.0 54 
112 330.0 166 
113 333.0 57 
114 336.0 169 
115 339.0 60 
116 342.0 172 
117 345.0 63 
118 348.0 175 
119 351.0 66 
120 354.0 178 
121 357.0 69 
122 360.0 181 
123 363.0 72 
124 366.0 184 
125 369.0 75 
126 372.0 187 
127 375.0 78 
128 378.0 190 
129 381.0 81 
130 384.0 193 
131 387.0 84 
132 390.0 196 
133 393.0 87 
134 396.0 199 
135 399.0 90 
136 402.0 202 
137 405.0 93 
138 408.0 205 
139 411.0 96 
140 414.0 208 
141 417.0 99 
142 420.0 211 
143 423.0 102 
144 426.0 214 
145 429.0 105 
146 432.0 217 
147 435.0 108 
148 438.0 220 
149 441.0 111 
149 441.0 2 R4INJECT 
150 444.0 2 
151 447.0 114 
151 447.0 5 R4MIX 
152 450.0 5 
153 453.0 117 
154 456.0 8 
155 459.0 120 
156 462.0 11 
157 465.0 123 
158 468.0 14 
159 471.0 126 
160 474.0 17 
161 477.0 129 
162 480.0 20 
163 483.0 132 
164 486.0 23 
165 489.0 135 
166 492.0 26 
167 495.0 138 
168 498.0 29 
169 501.0 141 
170 504.0 32 
171 507.0 144 
172 510.0 35 
173 513.0 147 
174 516.0 38 
175 519.0 150 
176 522.0 41 
177 525.0 153 
178 528.0 44 
179 531.0 156 
180 534.0 47 
181 537.0 159 
182 540.0 50 
183 543.0 162 
184 546.0 53 
185 549.0 165 
186 552.0 56 
187 555.0 168 
188 558.0 59 
189 561.0 171 
190 564.0 62 
191 567.0 174 
192 570.0 65 
193 573.0 177 
194 576.0 68 
195 579.0 180 
196 582.0 71 
197 585.0 183 
198 588.0 74 
199 591.0 186 
200 594.0 77 
201 597.0 189 
201 597.0 80 WD1 
202 600.0 80 
203 603.0 192 
203 603.0 83 WD2 
204 606.0 83 
205 609.0 195 
205 609.0 86 WD3 
206 612.0 86 
207 615.0 198 
207 615.0 89 WD4 
208 618.0 89 
209 621.0 201 
209 621.0 92 WD5 
210 624.0 92 
211 627.0 204 
211 627.0 95 WD6 
212 630.0 95 
213 633.0 207 
214 636.0 98 CB1 
215 639.0 210 
216 642.0 101 CB2 
217 645.0 213.0 
217 645.0 104 WD7 
218 648.0 104 
219 651.0 216 
219 651.0 107 WD8 
220 654.0 107 
221 657.0 219 
______________________________________ 
TABLE II 
______________________________________ 
Step Time Pos. Job 
______________________________________ 
1 -4.5 155 
1 -4.5 1 R1INJECT 
1 -4.5 1 
2 0.0 46 
2 0.0 113 SAMPLE INJECT 
2 0.0 113 
3 4.5 158 
3 4.5 4 R1MIX 
3 4.5 4 
4 9.0 49 
4 9.0 116 
5 13.5 161 
5 13.5 7 
6 18.0 52 
6 18.0 119 
7 22.5 164 
7 22.5 10 
8 27.0 55 
8 27.0 122 
9 31.5 167 
9 31.5 13 
10 36.0 58 
10 36.0 125 
11 40.5 170 
11 40.5 16 
12 45.0 61 
12 45.0 128 
13 49.5 173 
13 49.5 19 
14 54.0 64 
14 54.0 131 
15 58.5 176 
15 58.5 22 
16 63.0 67 
16 63.0 134 
17 67.5 179 
17 67.5 25 
18 72.0 70 
18 72.0 137 
19 76.5 182 
19 76.5 28 
20 81.0 73 
20 81.0 140 
21 85.5 185 
21 85.5 31 
22 90.0 76 
22 90.0 143 
23 94.5 188 
23 94.5 34 
24 99.0 79 
24 99.0 146 
25 103.5 191 
25 103.5 37 R2INJECT 
25 103.5 37 
26 108.0 82 
26 108.0 149 
27 112.5 194 
27 112.5 40 R2MIX 
27 112.5 40 
28 117.0 85 
28 117.0 152 
29 121.5 197 
29 121.5 43 
30 126.0 88 
30 126.0 155 
31 130.5 200 
31 130.5 46 
32 135.0 91 
32 135.0 158 
33 139.5 203 
33 139.5 49 
34 144.0 94 
34 144.0 161 
35 148.5 206 
35 148.5 52 
36 153.0 97 
36 153.0 164 
37 157.5 209 
37 157.5 55 
38 162.0 100 
38 162.0 167 
39 166.5 212 
39 166.5 58 
40 171.0 103 
40 171.0 170 
41 175.5 215 
41 175.5 61 
42 180.0 106 
42 180.0 173 
43 184.5 218 
43 184.5 64 
44 189.0 109 
44 189.0 176 
45 193.5 221 
45 193.5 67 
46 198.0 112 
46 198.0 179 
47 202.5 3 
47 202.5 70 
48 207.0 115 
48 207.0 182 
49 211.5 6 
49 211.5 73 
50 216.0 118 
50 216.0 185 
51 220.5 9 
51 220.5 76 
52 225.0 121 
52 225.0 188 
53 229.5 12 
53 229.5 79 
54 234.0 124 
54 234.0 191 
55 238.5 15 
55 238.5 82 
56 243.0 127 
56 243.0 194 
57 247.5 18 
57 247.5 85 
58 252.0 130 
58 252.0 197 
59 256.5 21 
59 256.5 88 
60 261.0 133 
60 261.0 200 
61 265.5 24 
61 265.5 91 
62 270.0 136 
62 270.0 203 
63 274.5 27 
63 274.5 94 
64 279.0 139 
64 279.0 206 
65 283.5 30 
65 283.5 97 
66 288.0 142 
66 288.0 209 
67 292.5 33 
67 292.5 100 
68 297.0 145 
68 297.0 212 
68 297.0 36 R3 (45) INJECT 
69 301.5 36 
69 301.5 103 
70 306.0 148 
70 306.0 215 
70 306.0 39 R3MIX (45) 
71 310.5 39 
71 310.5 106 
72 315.0 151 
72 315.0 218 
73 319.5 42 
73 319.5 109 
74 324.0 154 
74 324.0 221 
75 328.5 45 
75 328.5 112 
76 333.0 157 
76 333.0 3 
77 337.5 48 
77 337.5 115 
78 342.0 160 
78 342.0 6 
79 346.5 51 
79 346.5 118 
80 351.0 163 
80 351.0 9 
81 355.5 54 
81 355.5 121 
82 360.0 166 
82 360.0 12 
83 364.5 57 
83 364.5 124 
84 369.0 169 
84 369.0 15 
85 373.5 60 
85 373.5 127 
86 378.0 172 
86 378.0 18 
87 382.5 63 
87 382.5 130 
88 387.0 175 
88 387.0 21 
89 391.5 66 
89 391.5 133 
90 396.0 178 
90 396.0 24 
91 400.5 69 
91 400.5 136 
92 405.0 181 
92 405.0 27 
93 409.5 72 
93 409.5 139 
94 414.0 184 
94 414.0 30 
95 418.5 75 
95 418.5 142 
96 423.0 187 
96 423.0 33 
97 427.5 78 
97 427.5 145 
98 432.0 190 
98 432.0 36 
99 436.5 81 
99 436.5 148 
100 441.0 193 
100 441.0 39 
101 445.5 84 
101 445.5 151 
102 450.0 196 
102 450.0 42 
103 454.5 87 
103 454.5 154 
104 459.0 199 
104 459.0 45 
105 463.5 90 
105 463.5 157 
106 468.0 202 
106 468.0 48 
107 472.5 93 
107 472.5 160 
108 477.0 205 
108 477.0 51 
109 481.5 96 
109 481.5 163 
110 486.0 208 
110 486.0 54 
111 490.5 99 
111 490.5 166 
112 495.0 211 
112 495.0 57 
113 499.5 102 
113 499.5 169 
114 504.0 214 
114 504.0 60 
115 508.5 105 
115 508.5 172 
116 513.0 217 
116 513.0 63 
117 517.5 108 
117 517.5 175 
118 522.0 220 
118 522.0 66 
119 526.5 111 
119 526.5 178 
119 526.5 2 R4 (45) INJECT 
120 531.0 2 
120 531.0 69 
121 535.5 114 
121 535.5 181 
121 535.5 5 R4MIX 
122 540.0 5 
122 540.0 72 
123 544.5 117 
123 544.5 184 
124 549.0 8 
124 549.0 75 
125 553.5 120 
125 553.5 187 
126 558.0 11 
126 558.0 78 
127 562.5 123 
127 562.5 190 
128 567.0 14 
128 567.0 81 
129 571.5 126 
129 571.5 193 
130 576.0 17 
130 576.0 84 
131 580.5 129 
131 580.5 196 
132 585.0 20 
132 585.0 87 
133 589.5 132 
133 589.5 199 
134 594.0 23 
134 594.0 90 
135 598.5 135 
135 598.5 202 
136 603.0 26 
136 603.0 93 
137 607.5 138 
137 607.5 205 
138 612.0 29 
138 612.0 96 
139 616.5 141 
139 616.5 208 
140 621.0 32 
140 621.0 99 
141 625.5 144 
141 625.5 211 
142 630.0 35 
142 630.0 102 
143 634.5 147 
143 634.5 214 
144 639.0 38 
144 639.0 104 
145 643.5 150 
145 643.5 217 
146 648.0 41 
146 648.0 108 
147 652.5 153 
147 652.5 220 
148 657.0 44 
148 657.0 111 
149 661.5 156 
149 661.5 2 
150 666.0 47 
150 666.0 114 
151 670.5 159 
151 670.5 5 
152 675.0 50 
152 675.0 117 
153 679.5 162 
153 679.5 8 
154 684.0 53 
154 684.0 120 
155 688.5 165 
155 688.5 11 
156 693.0 56 
156 693.0 123 
157 697.5 168 
157 697.5 14 
158 702.0 59 
158 702.0 126 
159 706.5 171 
159 706.5 17 
160 711.0 62 
160 711.0 129 
161 715.5 174 
161 715.5 20 
162 720.0 65 
162 720.0 132 
163 724.5 177 
163 724.5 23 
164 729.0 68 
164 729.0 135 
165 733.5 180 
165 733.5 26 
166 738.0 71 
166 738.0 138 
167 742.5 183 
167 742.5 29 
168 747.0 74 
168 747.0 141 
169 751.5 186 
169 751.5 32 
170 756.0 77 
170 756.0 144 
171 760.5 189 
171 760.5 35 
172 765.0 80 
172 765.0 147 
173 769.5 192 
173 769.5 38 
174 774.0 83 
174 774.0 150 
175 778.5 195 
175 778.5 41 
176 783.0 86 
176 783.0 153 
177 787.5 198 
177 787.5 44 
178 792.0 89 
178 792.0 156 
179 796.5 201 
179 796.5 47 
180 801.0 92 
180 801.0 159 
181 805.5 204 
181 805.5 50 
182 810.0 95 
182 810.0 162 
183 814.5 207 
183 814.5 53 
184 819.0 98 
184 819.0 165 
185 823.5 210 
185 823.5 56 
186 828.0 101 
186 828.0 168 
187 832.5 213 
187 832.5 59 
188 837.0 104 
188 837.0 171 
189 841.5 216 
189 841.5 62 
190 846.0 107 
190 846.0 174 
191 850.5 219 
191 850.5 65 
192 855.0 110 
192 855.0 177 
193 859.5 1 
193 859.5 68 
194 864.0 113 
194 864.0 180 
195 868.5 4 
195 868.5 71 
196 873.0 116 
196 873.0 183 
197 877.5 7 
197 877.5 74 
198 882.0 119 
198 882.0 186 
199 886.5 10 
199 886.5 77 
200 891.0 122 
200 891.0 189 
201 895.5 13 
201 895.5 80 WD1 
201 895.5 80 
202 900.0 125 
202 900.0 192 
203 904.5 16 
203 904.5 83 WD2 
203 904.5 83 
204 909.0 128 
204 909.0 195 
205 913.5 19 
205 913.5 86 WD3 
205 913.5 86 
206 918.0 131 
206 918.0 198 
207 922.5 22 
207 922.5 89 WD4 
207 922.5 89 
208 927.0 134 
208 927.0 201 
209 931.5 25 
209 931.5 92 WD5 
209 931.5 92 
210 936.0 137 
210 936.0 204 
211 940.5 28 
211 940.5 95 WD6 
211 940.5 95 
212 945.0 140 
212 945.0 207 
213 949.5 31 
213 949.5 98 
214 954.0 143 CB1 
214 954.0 210 
215 958.5 34 
215 958.5 101 
216 963.0 146 CB2 
216 963.0 213 
217 967.5 37 
217 967.5 104 WD7 
217 967.5 104 
218 972.0 149 
218 972.0 216 
219 976.5 40 
219 976.5 107 WD8 
219 976.5 107 
220 981.0 152 
220 981.0 219 
221 985.5 43 
221 985.5 110 
______________________________________