The present invention relates to novel 9-deoxy-5,9.alpha.epoxy-5,6-didehydro-PGF.sub.1 amides, which are useful for inducing a variety of prostacyclin-like pharmacological effects. Accordingly, these compounds are useful pharmacological agents for the same purposes for which prostacyclin is employed.

BACKGROUND OF THE INVENTION 
The present invention relates to novel 
9-deoxy-5,9.alpha.-epoxy-5,6-didehydro-PGF.sub.1 amides, which are useful 
for inducing a variety of prostacyclin-like pharmacological effects. 
Accordingly, these compounds are useful pharmacological agents for the 
same purposes for which prostacyclin is employed. 
The essential material constituting a disclosure of the preparation and use 
of the novel compounds of the present invention is incorporated here by 
reference from U.S. Pat. No. 4,123,441. 
SUMMARY OF THE INVENTION 
The present invention particularly provides: 
a 4Z compound of the formula 
##STR1## 
wherein W.sub.1 is .alpha.-OH:.beta.-H, .alpha.-H:.beta.-OH, oxo, 
methylene, .alpha.-H:.beta.-H, .alpha.-CH.sub.2 OH:.beta.-H; 
wherein L is --(CH.sub.2).sub.d --C(R.sub.2).sub.2, 
wherein d is zero to 5, R.sub.2 is hydrogen, methyl, or fluoro, being the 
same or different with the proviso that one R.sub.2 is not methyl when the 
other is fluoro; 
wherein Q is oxo, .alpha.-H:.beta.-H, .alpha.-OH:.beta.-R.sub.8 or 
.alpha.-R.sub.8 :.beta.-OH 
wherein R.sub.8 is hydrogen or alkyl of one to 4 carbon atoms, inclusive; 
wherein R.sub.9 is hydrogen, methyl, or ethyl, and wherein R.sub.18 is 
hydrogen, alkyl of one to 4 carbon atoms, inclusive, aralkyl of 7 to 12 
carbon atoms, inclusive, phenyl, or phenyl substituted with alkyl of one 
to 4 carbon atoms, inclusive; 
wherein R.sub.5 and R.sub.6 are hydrogen, alkyl of one to 4 carbon atoms, 
inclusive, or fluoro, being the same or different, with the proviso that 
one of R.sub.5 and R.sub.6 is fluoro only when the other is hydrogen or 
fluoro and the further proviso that neither R.sub.5 nor R.sub.6 is fluoro 
when Z is oxa (--O--); wherein Z represents an oxa atom (--O--), a valence 
bond or alkylene of one to 9 carbon atoms, inclusive, with one to 6 carbon 
atoms, inclusive between CR.sub.5 R.sub.6 -- and the phenyl ring; 
wherein T is alkyl of one to 4 carbon atoms, inclusive, fluoro, chloro, 
trifluoromethyl, or --OR.sub.7 --, wherein R.sub.7 is alkyl of one to 4 
carbon atoms, inclusive, and s is zero, one, 2, or 3, with the proviso 
that not more than two T's are other than alkyl and when s is 2 or 3 the 
T's are either the same or different; and 
wherein X is 
(1) trans--CH.dbd.CH--, 
(2) cis--CH.dbd.CH--, 
(3) --C.tbd.C--, or 
(4) --CH.sub.2 CH.sub.2 --; 
including the lower alkanoates thereof; and a 4E compound of the formula 
##STR2## 
wherein W.sub.1 is .alpha.-OH:.beta.-H, .alpha.-H:.beta.-OH, oxo, 
methylene, .alpha.-H:.beta.-H, .alpha.-CH.sub.2 OH:.beta.-H; 
wherein L is --(CH.sub.2).sub.d --C(R.sub.2).sub.2, wherein d is zero to 5, 
R.sub.2 is hydrogen, methyl, or fluoro, being the same or different with 
the proviso that one R.sub.2 is not methyl when the other is fluoro; 
wherein Q is oxo, .alpha.-H:.beta.-H, .alpha.-OH:.beta.-R.sub.8 or 
.alpha.-R.sub.8 :.beta.-OH 
wherein R.sub.8 is hydrogen or alkyl of one to 4 carbon atoms, inclusive; 
wherein R.sub.9 is hydrogen, methyl, or ethyl, and wherein R.sub.18 is 
hydrogen, alkyl of one to 4 carbon atoms, inclusive, aralkyl of 7 to 12 
carbon atoms, inclusive, phenyl, or phenyl substituted with alkyl of one 
to 4 carbon atoms, inclusive; 
wherein R.sub.5 and R.sub.6 are hydrogen, alkyl of one to 4 carbon atoms, 
inclusive, or fluoro, being the same or different, with the proviso that 
one of R.sub.5 and R.sub.6 is fluoro only when the other is hydrogen or 
fluoro and the further proviso that neither R.sub.5 nor R.sub.6 is fluoro 
when Z is oxa (--O--); where Z represents an oxa atom (--O--), a valence 
bond or alkylene of one to 9 carbon atoms, inclusive, with one to 6 carbon 
atoms, inclusive between CR.sub.5 R.sub.6 - and the phenyl ring; 
wherein T is alkyl of one to 4 carbon atoms, inclusive, fluoro, chloro, 
trifluoromethyl, or --OR.sub.7 --, wherein R.sub.7 is alkyl of one to 4 
carbon atoms, inclusive, and s is zero, one, 2, or 3, with the proviso 
that not more than two T's are other than alkyl and when s is 2 or 3 the 
T's are either the same or different; and 
wherein X is 
(1) trans--CH.dbd.CH--, 
(2) cis--CH.dbd.CH--, 
(3) --C.tbd.C--, or 
(4) --CH.sub.2 CH.sub.2 --; 
including the lower alkanoates thereof. 
With regard to the divalent substituents described in the claims, e.g., Q 
and W.sub.1, these divalent radicals are defined as .alpha.-R.sub.i 
:.beta.-R.sub.j, where R.sub.i represents a substituent of the divalent 
moiety of the alpha configuration with respect to the cyclopentane and 
R.sub.j represents a substituent of the divalent moiety of the beta 
configuration with respect to the cyclopentane ring. Accordingly, when Q 
is defined as .alpha.-OH:.beta.-R.sub.8, the hydroxy of the Q moiety is in 
the alpha configuration, i.e., as in prostacyclin, and the R.sub.8 
substituent is in the beta configuration. Not all carbon atoms to which 
such divalent moieties are attached represent asymmetric centers. For 
example, when both valence bonds are to hydrogen (e.g., W.sub.1 or Q is 
.alpha.-H:.beta.-H), then no asymmetric center is present.