A handheld Multi-chamber dispensing system comprising a connecting body configured for accepting multiple liquid compound vials/cartridges for attachment. A triple location within the connecting body with at least three separate reservoirs. The modules/vials containing at least one dose of a liquid compound and configured for fluid communication with a delivery spout. A microprocessor controlled circuit that serves as a controller for the multiple reservoirs of liquid compounds.

TECHNICAL FIELD

This invention relates to a medical dispensing device and method of delivering two or more medicaments or agents from isolated reservoirs using a dispensing device with two or more separate chambers or reservoirs. More specifically, the present invention is directed to a dual or Multi-chamber module comprising a separate reservoir housing a medicament and at least a second separate reservoir housing another medicament. The separate chambers may provide a user an option of micro-dosing each medicament to a custom level dictated by the user's tolerance or health care professional. The medicaments may be available in two or more chambers each containing independent (single molecule compounds) or pre-mixed (co-formulated multiple molecule compounds). Additionally, the present invention may be optimized for a specific target patient group through control of a dosing and definition of a therapeutic profile.

BACKGROUND

Cannabisis a substance derived from the hemp plant (Cannabis indicaorCannabis sativa). Derived materials include cannabinoids, terpenes and flavonoids. In this specification these, and other derivatives, are referred to generically ascannabismolecules.

After decarboxylation, Cannabidiol (CBD) and tetrahydrocannabinol (THC) are the two main ingredients in thecannabisplant. Both CBD and THC belong to a unique class of compounds known as cannabinoids.

THC is probably best known for being the psychoactive ingredient incannabis. CBD, however, is non-psychoactive. In other words, CBD can't get you high. While disappointing to recreational users, this unique feature of CBD is what makes it appealing as a medicine.

Certain mood disorders require treatment using one or more different medicaments. The sensitivity to drugs for people with mood disorders is common and there is no “one size fits all” solution to the problem. Cannabinoid treatment for mood disorders is a relatively new science, however, it is known that too muchcannabiscan negatively affect the condition and patient being treated.

Patients prefer and/or require cannabinoid and terpene compounds to be delivered in a specific relationship with each other in order to deliver the optimum therapeutic dose. This invention is of particular benefit where combination therapy is desirable, but not possible in a single formulation for reasons such as, but not limited to, stability, dose amount, dose control and compromised therapeutic performance and toxicology.

Micro-dosingcannabisinvolves taking a very measured micro-dose of THC, the psychoactive ingredient, and a measured micro-dose of CBD, the non-psychoactive therapeutic ingredient incannabis.

With micro-dosing, users get the maximum benefit from the minimum amount, without becoming overly affected.

Right now, anyone that wants to micro-dose faces two hurdles: finding the right minimum dose and finding products that will deliver it.

The ability to set a dose of one cannabinoid (such as THC) to a custom level and also having ability to custom set the dose of a separate cannabinoid or mixture of cannabinoids (such as CBD) may give the healthcare professionals and patients the flexibility to titrate the medicinal compounds up or down with more precision. The present invention may give the opportunity for precisely varying the quantity of one or both reservoirs of cannabinoids. For example, one fluid quantity may be varied by changing the programming of the dispensing device. This may be completed by dialing a user variable dose or changing the device's “fixed” dose. The second medicament quantity may be changed exactly the same way. The user or healthcare professional may then select the most appropriate micro-dosing quantity for a particular treatment regime.

Cannabinoids (CBD, THC, etc.) are hydrophobic substances. They can, however, be formulated to be water-compatible and appear water-soluble.

CBD, THC and other oils can, however, be made water-compatible if they are formulated as oil-in-water nanoemulsions, which are stable and visually homogeneous oil/water mixtures. Nanoemulsions can be prepared in concentrated forms (tens of mg/ml) that are fully miscible with water and, therefore, appear water-soluble. In addition, nanoemulsions can be made translucent and practically tasteless, which means that they can be mixed into water without compromising its optical clarity or taste.

Nanoemulsions are beneficial because they are easily mixed into beverages, translucent, low-taste and safe for consumption, exceptionally high bioavailability, fast onset of action, and stable blood level and high CBD/THC loading capacity.

The present invention combines the Multi-chamber dispensing device with nanoemulsion technology to provide a precise, high water soluble and bioavailable product for medicinalcannabisconsumption.

These and other advantages will become evident from the following more detailed description of the invention.

SUMMARY OF THE INVENTION

The present invention discloses modules, systems and methods that allow for the dose controlled dual or multiple dispensing of medicaments within a single device. Preferably, such a system includes two dispensing spouts each individually attached to separate liquid chambers. Each individual chamber is attached to a stepper motor that is linked to software-driven motor control for precise dispensing of liquid compounds.

A user can set and dispense a pre-determined dose of medicaments through one chamber and set a different dose to dispense from the other chamber. Preferably, the dual compound dispenser interface may be programmed to dispense each chamber with a preset micro-dose. The multiple chambered dose setter controls step motors of the device such that a predefined quantity of medicaments is delivered when each chambered dose is set and dispensed through the dual compound dispense interface.

DETAILED DESCRIPTION

In the Summary above and in this Detailed Description, and the claims below, and in the accompanying drawings, reference is made to particular features of the invention. It is to be understood that the disclosure of the invention in this specification includes all possible combinations of such particular features. For example, where a particular feature is disclosed in the context of a particular aspect or embodiment of the invention, or a particular claim, that feature can also be used—to the extent possible—in combination with and/or in the context of other particular aspects and embodiments of the invention, and in the invention generally

The term “at least” followed by a number is used herein to denote the start of a range including that number (which may be a range having an upper limit or no upper limit, depending on the variable being defined). For example, “at least 1” means 1 or more than 1. The term “at most” followed by a number is used herein to denote the end of a range, including that number (which may be a range having 1 or 0 as its lower limit, or a range having no lower limit, depending upon the variable being defined). For example, “at most 4” means 4 or less than 4, and “at most 40%” means 40% or less than 40%. When, in this specification, a range is given as “(a first number) to (a second number)” or “(a first number)-(a second number),” this means a range whose limits include both numbers. For example, “25 to 100” means a range whose lower limit is 25 and upper limit is 100, and includes both 25 and 100.

The present invention is directed to a system for administering a precise, customized dose of two or more medicaments. Setting the dose of the medicaments by the user gives the patient more reliable control over the therapeutic outcome of micro-dosed therapy. These combined variable doses are preferable over single dose therapy. In a preferred arrangement, the compound dispensing interface comprises a hollow spout for delivery of liquid compounds. The system may include touch pad interface for simple UP and DOWN control of dosing device.

FIG. 2shows an exploded view of a multi-chamber medicament dispensing device.FIG. 2shows three medicament vials201connected to stepper motors202, a plunger203at the end of each stepper motor202, a circuit board assembly204, a charging port205, a front housing206and rear housing207, a dispensing spout208at the end of each vial, an end cap209, an indicator screen210, adjustment UP and DOWN keypad buttons211, a dispensing button212, and an ON/OFF button213.

The front housing206and rear housing207cover the circuit board assembly204, and the stepper motors202but leave the tips of vials201exposed for simple vial replacement. The end cap209covers the cylindrical shaped vials201after each use.

Externally the ON/OFF button213controls the power of device which times out after 30 seconds of non-use. The indicator screens210show the amount of the dose chosen by the UP and DOWN keypad buttons211. The dispensing button212activates the dispensing process which precisely controls all three chambers of the medicaments.

FIG. 3illustrates a cross-sectional view of the multi-chamber medicament dispensing device and the compound delivery vials201illustrated inFIG. 2.

FIG. 4illustrates a perspective exploded view of the vials201ofFIG. 2. The dispensing spout208ofFIG. 2may be screwed unto the end of the vial201for a secure fit that is ready to dispense medicaments.FIG. 4shows the device with spout208ofFIG. 2removed from the device. Potential materials that this stopper could include, but are not limited to, are TPE (Thermoplastic Elastomers), Liquid Silicone Rubber (LSR) and natural rubbers. Alternative materials, including Low-density Polyethylene (LDPE) or Linear low-density Polyethylene (LLDPE) are also possible.

FIG. 6illustrates the face view of the multi-chamber medicament dispensing device showing the UP and DOWN dose control buttons211with numbered LED display210ofFIG. 2.

Where the triple dispenser device10comprises dose setter buttons100, a dose of the dispensing device10may then be set using a dose setter buttons100in the normal manner (e.g., by dialing out the appropriate number of units). Dispensation of the liquid compound may then be achieved by dispensing water soluble liquid contents via activation of the GO button110on device10. In a preferred embodiment, the dose buttons100are operably connected to PCB assembly that engages each stepper motor to push on reservoirs of each vial of the liquid medicaments.

As mentioned above, in any of the methods described herein, appropriate liquid medicaments to be infused may be used. In general, the water soluble liquid medicaments may be cannabinoid oils or terpenes. The liquid medicament may comprise any active ingredient(s). For example, the liquid medicament may comprise a botanical. The medicament may comprise a cannabinoid. The medicament may comprise one or more of: cetirizine, ibuprofen, naproxen, omeprazole, doxylamine, diphenhydramine, melatonin, or meclizine. The medicament may comprise one or more of: a polyphonel, short chain fatty acids, medium chain fatty acids, long chain fatty acids, a green tea catechin, caffeine, a phenol, a glycoside, a labdane diterpenoid, yohimbine, a proanthocyanidin, terpene glycoside, an omega fatty acid, echinacoside, an alkaloid, isovaleric acid, a terpene, gamma-aminobutyric acid, asennaglycoside, cinnamaldehyde, or Vitamin D.

Although the preceding description contains significant detail in relation to the preferred embodiment, it should not be construed as limiting the scope of the invention but rather as providing illustrations of the preferred embodiments.

By defining the therapeutic relationship between the individual cannabinoid compounds our delivery device would help ensure that a patient/user receives the optimum therapeutic combination dose from a multi-cannabinoid compound device without the inherent risks associated with single dose devices. The cannabinoids and terpenes can be water soluble fluids that make it easy to dispense, dissolve and mix into beverage of choice.

This invention is of particular benefit to patients with THC sensitivity and who are not sure of what dose will work best for their condition. Giving the user the ability to titrate up or down in micro-doses insures better patient tolerance and therapeutic benefits. This invention eliminates the need for trial and error single dose consumption that current dropper based systems offer. This invention is also of particular benefit to patients experiencing the fear or phobia associated with THC consumption.

In the preferred embodiment, the primary delivery device has replaceable modules or vials and can be used more than once and therefore is multi-use. It is possible to have a selection of different cannabinoid vials/modules for various conditions that could be prescribed to patients.

In a further embodiment the delivery system comprises a software driven, battery powered printed circuit board coupled to two or more stepper motors with a plunging feature allowing for the software control and tracking of each precise dose.

In a further embodiment the medicament delivery system according to the invention disclosed herein comprises a mechanical non-motorized stepper feature, wherein both chambers have a mechanical plunger feature that are part of the medicament delivery device according the invention in this disclosure.

In a further embodiment, the dispenser unit has an interface to cell phone or tablet devices, such as Wi-Fi or Bluetooth if wireless, USB or Ethernet if wired; whereby a mobile device becomes the controlling device for the dispenser. The actual method or backbone for interface to the controlling device is not critical to the invention, and should not be used to narrow rights to future claims.

Related applications include patent applications 200400749321 and WO2010129835A2, and U.S. Pat. Nos. 6,159,188A and 9,884,336. These references do not teach the entire present invention.