Skin treatment composition and method for treating burned skin

Skin treatment compositions are provided which counteract moisture loss and promote healing of burned or sunburned skin which include a unique moisturizing component formed of polyglycerylmethacrylate, glycerine, allantoin, panthenol, amino acid complex, and fibronectin.

FIELD OF THE INVENTION 
The present invention relates to an improved skin treatment composition 
which counteracts moisture loss and promotes healing of burned skin or 
sunburned skin and to a method for treating such burned skin by applying 
such skin treatment composition to the skin. 
BACKGROUND OF THE INVENTION 
Aging and burning of skin are similar in that they each rob the skin of 
moisture and thus deplete oxygen and nourishment. Accordingly, bring 
moisture to either aging skin or burned skin and you bring oxygen and 
nourishment which are vital to the skin repairing itself. 
Until now, skin moisturizer compositions have been available which contain 
animal, vegetable and/or mineral oils which impart a greasy feel to the 
compositions and thus may stain clothes. To overcome this problem, it has 
been suggested to employ aqueous-based moisturizers. Although various 
aqueous-based moisturizers have achieved some degree of commercial 
success, they have been far from satisfactory in actually replenishing 
moisture in aging and/or burned skin. 
DESCRIPTION OF THE INVENTION 
This invention is directed to improved non-greasy skin treatment 
compositions for replenishing moisture in the skin, especially burned skin 
or sunburned skin, and which includes a moisturing component formed of a 
combination of various moisturizing and wound healing compounds, debriding 
agents and cell growth stimulants, which moisturizing component is present 
in an amount within the range of from about 2 to about 30% by weight and 
preferably from about 5 to about 15% by weight of the composition. 
In addition, depending upon the form that the skin treatment composition of 
the invention will take, it will also include water, at least one 
emulsifier and/or thickener and/or bodying agent, and at least one 
preservative, and optionally may contain one or more chelating agents, one 
or more gelling agents, one or more emollients, one or more other 
humectants, one or more sun screen agents, and/or one more fragrances 
and/or one or more coloring agents. 
The skin treatment composition of the invention is preferably an 
oil-in-water type emulsion since this type of emulsion affords better 
cosmetic feel to the product. However, the product could also be 
formulated as a water-in-oil emulsion, cream base, gel, aqueous/alcoholic 
or glycol solution or microemulsion. Depending upon the choice of 
ingredients, the formulation has a semi-solid cream-like consistency which 
can be packaged in a plastic squeeze tube, a lotion type consistency which 
can be packaged in a plastic squeeze container, an ointment-type 
consistency which can be packaged in a squeeze type container or a liquid 
consistency which may be packaged in a bottle. The container can include a 
flow-type cap or pump-type dispenser. 
In addition, in accordance with the present invention, a method is provided 
for treating burned or sunburned skin to promote healing which includes 
the step of applying to the skin an effective amount of a skin treatment 
composition as disclosed herein. 
The skin treatment composition of the invention may take the form of a 
location, cream, liquid, or ointment. 
The moisturizing component of the composition of the invention will include 
polyglyceryl methacrylate which serves as a film-former and moisturizer in 
an amount within the range of from about 1 to about 10% and preferably 
from about 3 to about 7% by weight of the moisturizing component, 
glycerine which serves as a humectant-moisturizer in an amount within the 
range of from about 1 to about 8% and preferably from about 2 to about 5% 
by weight of the moisturizing component; allantoin (which may be in the 
form of a complex of allantoin and N-acetyl dl methionine) which has 
cellular stimulating activity, increases cellular respiration, increases 
water binding properties of the stratum corneum and promotes normal cell 
sloughing, in an amount within the range of from about 0.1 to about 0.5% 
and preferably from about 0.1 to about 0.4% by weight of the moisturizing 
component, panthenol (d- or dl-) which serves to accelerate healing of 
various types of burns, has moisturizing properties and easily penetrates 
the epidermis and has smoothing anti-inflammatory properties on skin, in 
an amount within the range of from about 0.5 to about 5% and preferably 
from about 1 to about 3% by weight of the moisturizing component; amino 
acid complex which includes proline, arginine, pyrrolidone carboxylic acid 
and optionally glycine, which serves to penetrate skin to promote moisture 
retention with the epidermis and stimulate cell growth, in an amount 
within the range of from about 0.05 to about 5% and preferably from about 
0.1 to about 2% by weight of the moisturizing component, and fibronectin 
aqueous solution which serves to enhance cell to cell adhesion and thus 
promotes wound healing in an amount within the range of from about 0.005 
to about 1.5% and preferably from about 0.007 to about 0.3% by weight of 
the moisturizing component (said fibronectin being formulated as an 0.2 to 
5% aqueous solution). 
The polyglycerylmethacrylate component is in the form of a white 
transparent gel containing from about 50 to about 75% by weight solids, 
and may or may not contain incidental ingredients, such as propylene 
glycol which may be present in an amount of 2% or less (preferably about 
1%). A preferred polyglycerylmethacrylate is Lubrajel, a registered 
trademark of United Guardian Inc., which is distributed by Meadow 
Technical Corp., Livingston, N.J. A preferred form of Lubrajel as a 9% 
solution has a viscosity at 25.degree. C. (Brookfield RVT, spindle No. 4, 
at 50 rpm) ranging from about 700 to about 1,000 cps, a specific gravity 
of 1 to 1.2 mg/ml, is completely soluble in water and is substantially 
stable at 25020 F. Lubrajel is a clathrate formed by the reaction of 
glycerin and methylmethacrylate. 
The polyglycerylmethacrylate may be employed by itself or as a dispersion 
with other polyols, such as propylene glycol or any of the polyols 
mentioned hereinafter, in amounts of 2% or less, preferably about 1%. 
In general, regardless of the form of the skin treatment composition of the 
invention, it will include from about 2 to about 30%, and preferably from 
about 5 to about 15% by weight of the moisturizing component, from about 
50 to about 90% and preferably from about 60 to about 80% by weight water, 
from about 0 to about 25% and preferably from about 2 to about 10% by 
weight of one or more other humectants, from about 1 to about 10% and 
preferably from about 1 to about 5% by weight of one or more emulsifiers 
when the composition is a cream, lotion, or gels, from about 0.05 to about 
10% and preferably from about 0.05 to about 8% by weight of one or more 
thickeners, wax bodying agent or gelling agents where the composition is a 
cream or lotion or gel, from about 0.05 to about 2% and preferably from 
about 0.1 to about 1% by weight of one or more preservatives, and the 
following optional ingredients: from about 0.01 to about 0.5% and 
preferably from about 0.05 to about 0.1% by weight of one or more 
chelating agents, from about 1 to about 30% and preferably from about 1 to 
about 10% by weight of one or more emollients when the composition is a 
cream, lotion or gel, from about 1 to about 50% and preferably from about 
5 to about 10% by weight of one or more solvents, from about 1 to about 
15% and preferably from about 1.5 to about 10% by weight of one or more 
sun screen agents, less than about 1% by weight of one or more fragrances 
and/or less than about 1% by weight of one or more colorants. In addition, 
the skin treatment composition of the invention may also optionally 
include various other conventional ingredients normally employed in skin 
conditioning or moisturizing compositions or sunscreen compositions such 
as skin conditioning agents, moisturizers, waxes, polymers or other active 
ingredients. 
Suitable preservatives include imidazoli-dinyl urea (Germall 115), 
diazolidinyl urea (Germall II), methylparaben (Tegosept M), quaternium-15 
(N-(3-chloroallyl)hexaminium chloride, Dowicil 200), propylparaben 
(Tegosept P), dimethyldimethoyl hydantoin, benzyl alcohol and/or 
phenoxyethanol, etc., and a preferred antioxidant is a mixture of 
butylated hydroxyanisole, propylene glycol, propyl gallate and citric acid 
(Tenox 2). The formation will preferably contain the antioxidant mixture 
and one or more of the preservatives or any other preservatives and 
antioxidants approved for cosmetic use. 
Where the skin treatment composition of the invention is in the form of a 
lotion, cream, or ointment, it will preferably include one or more 
emulsifiers, thickeners, humectants and emoillients. 
Suitable emulsifiers include polyethylene glycol 20 sorbitan monolaurate 
(Polysorbate 20), polyethylene glycol 5 soya sterol, sorbitan tristearate, 
sorbitan trioleate, glyceryl, monopalmitate, diethanolamine cetyl 
phosphate, glyceryl monopalmitate, glyceryl monostearate, polyethylene 
glycol 100 stearate, polyethylene glycol 20 stearyl ether (Brij 78, 
Steareth 20), polyethylene glycol ether of lauryl alcohol (Laureth 23), 
polysorbate 80 (Tween 80), lecithin, etc. The formulation will preferably 
contain a mixture of two or more of these emulsifiers or others which are 
approved for cosmetic use. 
Thickeners, gelling agents or wax-bodying agents which may be present 
include Carbopol 934 or Carbomer 940 which is a hydrophilic acrylic 
polymer cross-linked with a polyfunctional agent and employed with an 
organic or inorganic base, preferably triethanolamine. Other examples of 
thickeners which may be employed herein include, but are not limited to, 
stearic acid, fatty alcohols, such as cetyl alcohol, stearyl alcohol, 
magnesium aluminum silicate, dimethicone, stearoxydimethicone, 
hydroxyethyl cellulose, propylene glycol monostearate, glyceryl 
monostearate, hydroxypropyl cellulose, carboxy-methyl cellulose, xanthan 
gum, myristyl stearate, or cetyl stearate. 
Suitable emollients include glyceryl monooleate, myristyl alcohol, 
isopropyl palmitate, C.sub.12 -C.sub.15 -alcohol benzoates (Finsolv TN), 
octyl palmitate, propylene glycol dicaprylate/dicaprate, isopropyl 
myristate, diisopropyl dimerate (that is, the diester of isopropyl alcohol 
and dimer acid), dimethicone, stearoxydimethicone, and the like. The 
formulation will preferably contain a mixture of several of these 
emollients or others which are approved for cosmetic use. 
Skin conditioning agents which may optionally be present in the composition 
of the invention include hydrolyzed animal protein as disclosed in U.S. 
Pat. No. 4,374,766. Such conditioning agents may be present in an amount 
within the range of from about 0.01 to about 10% and preferably from about 
0.05 to about 2% by weight and optimally from about 0.1 to about 2% by 
weight depending upon the ultimate use of the skin preparation. 
Humectants which may be present include propylene glycol, glycerine or 
polyethylene glycol wax (such as Carbowax 400). 
Chelating agents for sequestering metal ions in aqueous solution which may 
be present herein include disodium ethylenediamine tetraacetic acid, EDTA, 
tetrasodium EDTA, or citric acid. 
As indicated, the skin treatment compositions of the invention may include 
one or more known ultraviolet absorbing agents, preferably at least one 
compound which absorbs in the UV-B region (wavelength 290 to 320 
nanometers) and optionally one or more other compounds which absorb in the 
UV-A region (wavelength 320 to 400 nanometers). The total amount of UV 
absorbing agents included within the formulation will be from about 2% to 
about 15% by weight, which amount will determine whether it is a sunscreen 
or sunblock. 
Suitable UV-A absorbing agents which may be employed include 
2-(2'-hydroxy-5'-methylphenyl)-benzotriazole (Tinuvin P); 
2-(2'-hydroxy-5'-t-octyl-phenyl)benzotriazole (Spectra-Sorb UV 5411); 
2,4-dihydroxybenzophenone (Uvinul 400); 2-hydroxy-4-methoxybenzophenone 
(oxybenzone, Spectra-Sorb UV9, Uvinul M-40); 
2,2',4,4'-tetrahydroxybenzophenone (Uvinul D50); 
2,2'-dihydroxy-4,4'-dimethoxybenzophenone (Uvinul D49); 
2,2'-dihydroxy-4-methoxy-benzophenone (dioxybenzone, Spectra-Sorb UV24); 
2-ethylhexyl-4-phenyl-benzophenone carbonate (Eusolex 3573); 
2-hydroxy-4-methoxy-4'-methyl-benzophenone (mexenone, Uvistat 2211); 
2-hydroxy-4-(n-octyloxy)benzophenone (octabenzone, Spectra-Sorb UV531); 
4-phenylbenzophenone (Eusolex 3490); and 
2-ethylhexyl-2-cyano-3,3'-diphenylacrylate (Uvinul N539); butyl 
methoxydibenzoyl methane (Parsol 1789), and benzphthalide (Escalol 547) as 
well as water-soluble sunscreens such as sulisobenzone. The UV-A absorbing 
agent or agents are present in the final product at from 0 to about 10% by 
weight of the formulation. The amount will vary according to the 
particular agent selected and whether the formulation is intended to 
minimize or permit tanning. Where a UV-A absorbing agent is employed, the 
preferred UV-A absorbing agent is 2-hydroxy-4-methoxybenzophenone alone or 
in combination with 2,2'-dihydroxy-4-methoxy-benzo-phenone. 
Suitable UV-B absorbing agents include 4-(dimethylamino)benzoic acid, ethyl 
ester; 4-(dimethylamino)benzoic acid, 2-ethylhexyl ester (Escalol 507); 
4-(dimethylamino)benzoic acid, pentyl ester (Escalol 506); glyceryl 
p-amino-benzoate (Excalol 106); isobutyl p-amino-benzoate (Cycloform); and 
isopropyl p-amino-benzoate; 2-ethylhexyl methoxy cinnamate (Parsol MCX); 
phenylbenzimidazole sulfonic acid (Eusolex 232) which is water-soluble 
when converted to its known salts; homomenthyl salicylate, and ethyl hexyl 
salicylate and diethanolamine methoxy cinnamate (Parsol Hydro, 
water-soluble). The UV-B absorbing agent or agents are present in the 
final product at from about 1% to about 15% by weight of the formulation. 
The amount will vary according to the particular agent selected and degree 
of protection desired in the final product. The preferred UV-B absorbing 
agent is 4-(dimethylamino)benzoic acid, 2-ethyl-hexyl ester (Escalol 507). 
Where the skin treatment composition is in the form of a location, cream, 
or liquid, any other active ingredients that may be present will be 
"all-in-solution" (i.e., solubilized or emulsified) so that substantially 
no active ingredient crystallizes out at room temperature. 
With regard to the cream formulations of the invention where the active 
ingredients are to be all-in-solution, the cream will contain from about 2 
to about 30% and preferably from about 5 to about 15% by weight of the 
moisturizing component based on the weight of the entire cream 
formulation; from about 0.05 to about 10% and preferably from about 3 to 
about 7% by weight based on the weight of the entire cream formulation of 
a thickneer or wax bodying agent, such as Carbomer 940, cetyl alcohol 
and/or stearic acid and/or other thickeners or bodying agents as set out 
above. The all-in-solution cream formulation will also include in the oil 
phase, from about 2 to about 15% and preferably from about 5 to about 10% 
by weight of the emulsifier-thickener based on the weight of the entire 
cream formulation, and from about 2 to 30% and preferably from about 3 to 
about 15% by weight of emollient based on the weight of the entire cream 
formulation. The oil phase may also include one or more preservatives 
similar to that present in the aqueous phase described below. 
The aqueous phase of the all-in-solution cream formulation may contain a 
glycol type preservative or humectant such as propylene glycol and/or a 
paraben or other conventional type perservative such methyl and/or propyl 
paraben, and purified water in amount within the range of from about 30 to 
about 80% by weight and preferably from about 35 to about 65% by weight of 
the entire cream formulation. 
With regard to the lotion formulation of the invention where the 
moisturizing component is to be all-in-solution, the lotion will contain 
from about 0.01 to about 5% and preferably from about 0.1 to about 0.5% by 
weight of the moisturizing component based on the weight of the entire 
lotion formulation. The active ingredient in the all-in-solution lotion 
formulation can have part of it also solubilized in the oil phase. The 
lotion may contain from about 1 to 10% and preferably from about 2 to 
about 5% by weight emulsifier-thickener based on the weight of the entire 
lotion formulation, and from about 2 to about 20% and preferably from 
about 4 to about 10% by weight of emollient based on the weight of the 
entire lotion formulation. The oil phase may also optionally include one 
or more preservatives. 
The aqueous phase of the all-in-solution lotion formulation may contain one 
or more preservatives and purified water in an amount within the range of 
from about 60 to about 90% by weight and preferably from about 70 to about 
85% by weight of the entire lotion formulation. 
Where the moisturizing component is to be employed in liquid solution, the 
concentration of moisturizing component will be in amounts ranging from 
about 2 to about 30% by weight together with from about 5 to about 15% by 
weight aqueous solvent therefor. 
The gel formulation of the invention is preferably in the form of a 
hydrophilic clear gel, and will contain from about 2 to about 30%, and 
preferably from about 5 to about 15% by weight of the moisturizing 
component based on the weight of the entire formulation, and from about 30 
to about 95% and preferably from about 50 to about 80% by weight of water 
based on the weight of the entire formulation. The gel formulation may 
also include one or more humectants, preservatives, antioxidants, 
water-soluble sunscreens and one or more gelling agents or bodying agents 
(in an amount within the range of from about 0.2 to about 20% by weight 
and preferably from about 0.5 to about 10%) such as Carbomer 940 or 934, 
Lubragel, hydroxy-methylpropyl cellulose, propylene glycol alginate or 
other algal gums, such as Seamollient. 
In formulating the aqueous gel, unless otherwise indicated, the viscous 
ingredients may be employed in amounts indicate hereinbefore. 
Examples of preferred formulations in accordance with the present invention 
include, but are not limited to, the following: 
______________________________________ 
Range in 
% by weight of 
moisturizing 
component 
______________________________________ 
Moisturizing component 
Polyglycerylmethacrylate 
3 to 7 
Glycerine 2 to 5 
Allantoin 0.1 to 0.4 
Panthenol 1 to 3 
Amino acid complex 0.1 to 2 
Fibronectin (as an 0.4% aqueous 
0.007 to 0.3* 
solution 
______________________________________ 
Range in 
% by weight 
of total 
formulation 
______________________________________ 
Cream formulation 
Moisturizing component 5 to 15 
Solvents 5 to 10 
Emulsifiers 2 to 5 
Thickeners 2 to 20 
Humectant 2 to 20 
Chelating Agent 0.05 to 0.1 
Water 50 to 80 
Preservatives 0.2 to 1 
Lotion formulation 
Moisturizing component 5 to 15 
Solvents 5 to 10 
Emulsifiers 1 to 5 
Thickeners 1 to 10 
Humectants 2 to 10 
Chelating Agents 0.05 to 0.1 
Water 60 to 90 
Preservatives 0.2 to 1 
Solution or Liquid formulation 
Moisturizing component 5 to 15 
Water 75 to 90 
Humectants, preservatives, sunscreens, 
5 to 10 
chelating agents, antioxidants 
Aqueous gel 
Moisturizing component 5 to 15 
Water 50 to 80 
Gelling agent 0.5 to 10 
Humectants, preservatives, sunscreens 
5 to 10 
chelating agents, antioxidants 
______________________________________ 
(*Fibronectin by itself 0.000028 to 0.0012%)

The various formulations of the invention may be presented employing 
conventional procedures as outlined in the working examples. 
EXAMPLE 1 
A skin treatment composition in the form of a cream of the following 
composition was prepared as described below. 
______________________________________ 
Cream Formulation 
Parts by 
Ingredient Weight 
______________________________________ 
Blend I 
Deionized water 73 
Carbopol 940 (bodying agent) 
0.5 
Allantoin (part of moisturizing 
0.2 
component) 
DL-Panthenol (part of moisturizing 
1.5 
component) 
Simethicone (anti-foam agent) 
0.1 
Blend II 
Polyglycerylmethacrylate 
part of 5 
(Lubragel) moisturizing 
Glycerine component 3 
Blend III 
Propylene glycol (humectant) 
1 
Methyl paraben (preservative) 
0.2 
Blend IV 
Laureth 23 (Brij 35) (emulsifier) 
2 
C.sub.12 -C.sub.15 alcohol benzoates 
4 
(Finsolv TN) (emulsifier) 
Propylene glycol 2 
dicaprylate/dicaprate 
(Miglyol 840, emulsifier) 
Propyl paraben (preservative) 
0.1 
Cetyl alcohol 1.5 
thickener 
Stearic acid 1.5 
Sorbitan monostearate (emulsifier) 
1 
Blend V 
Deionized water 1.3 
Triethanolamine (thickener) 
1 
Blend VI 
Dimethyldimethoyl hydantoin 
0.3 
(Glydant) 
Blend VII 
Deionized water 1 
Fibronectin 0.01 
L-Proline part of 0.05 
L-Arginine moisturizing 
0.1 
Pyrrolidone carboxylic 
component 0.05 
acid (Ajidew A-100) 
______________________________________ 
Blend I was prepared by charging deionized water to a sweep kettle equipped 
with a homomixer; the Carbopol 940 was added and the mixture was homomixed 
for 30 minutes; the allantoin was added and the mixture was homomixed for 
2 minutes; DL-Pantenol was added and the mixture was homomixed for 2 
minutes; and the simethicone was added and the mixture was homomixed for 1 
minute. When the mixture was uniform, it was sweep-mixed while heating at 
78 to 80.degree. C. 
Blend IV was prepared by mixing all of the Blend IV ingredients except the 
sorbitan monostearate, propeller mixing while heating to 78 to 80.degree. 
C., at 78 to 80.degree. C. adding sorbitan monostearate and propeller 
mixing at 78 to 80.degree. C. 
The Blend III ingredients were mixed with propeller mixing while heating at 
40 to 45.degree. C. 
The Blend II ingredients were added to Blend I with sweep mixing and 
heating at 78 to 80.degree. C. 
The Blend V ingredients were premixed. 
When the Blend I-II mixture was at 78-80.degree. C. the Blend III mix was 
added to Blend I-II and the mixture was sweep mixed at 78-80.degree. C. to 
form Blend I, II, and III mix. 
The Blend IV mix (heated at 78 to 80.degree. C.) was added to the Blend 
I-II-III mix (heated at 78 to 80.degree. C.), and the Blend I to IV 
mixture was fast sweep mixed for 30 minutes at 78 to 80.degree. C. and 
then slow sweep mixed for 30 minutes. 
Blend V was added to the Blend I to IV mixture and the mix was speed mixed 
for 30 minutes and then slow sweep mixed for 20 minutes while at 
51.degree. C. The Blend I to IV was cooled to 40.degree. C. nd Blend VI 
was added thereto to form Blend I to VI. 
The Blend VII ingredients were premixed and Blend VII was added to Blend I 
to VI and the mixture was sweep mixed for 10 minutes and cooled to 
30.degree. C. ot form the cream of the invention. 
EXAMPLE 2 
A skin treatment formulation in the form of a lotion of the following 
composition was prepared as described below. 
______________________________________ 
Lotion Formulation 
Parts by 
Ingredient Weight 
______________________________________ 
Blend I 
Deionized water 71 
Sequestered Na.sub.2 EDTA (chelating 
0.1 
agent) 
Carbopol 940 (bodying agent) 
0.15 
Allantoin (part of moisturizing 
0.2 
component) 
dl-Panthenol (part of moisturizing 
1.5 
component) 
Blend II 
Polyglycerylmethacrylate-) 
part of 5 
(Lubrajel) moisturizing 
Glycerine component 3 
Blend III 
Propylene glycol 1 
Xanthan gum 0.1 
Blend IV 
Stearic acid (thickener) 1.4 
C.sub.12 -C.sub.15 Alcohol benzoates (emollient) 
4 
Propylene glycol 2 
dicaprylate/dicaprate 
Diisopropyl dimerate 2 
(Schercemol DID, emollient) 
Cetyl alcohol (bodying agent) 
0.8 
Steareth 20 (Brij 78, emulsifier) 
1.3 
Polysorbate 60 (Tween 60, emulsifier) 
1.3 
Blend V 
Deionized water 0.23 
Triethanolamine (thickener) 
0.23 
Blend VI 
Deionized water 1 
Imidizolidinyl urea (preservative) 
0.4 
Quaternium 15 (chloroallyl 
0.2 
methenamine chloride) (preservative) 
Blend VII 
Deionized water 1 
L-Proline 0.01 
L-Arginine Part of 0.02 
Pyrrolidone carboxylic moisturizing 
0.01 
acid component 
Glycine 0.2 
Fibronectin 0.01 
Fragrance 0.02 
______________________________________ 
The Example 2 lotion was prepared in a manner similar to that described in 
Example 1 except that heating was carried out at 75 to 78.degree. C. as 
opposed to 78 to 80.degree. C. and propeller mixing was preferred over 
sweep mixing. 
EXAMPLE 3 
______________________________________ 
Aqueous Gel 
Parts by 
Ingredient Weight 
______________________________________ 
Moisturizing component as described 
10 
in Example 1 
Carbomer 940 (gelling agent) 
0.5 
Water 88.5 
Triethanol amine (neutralizing agent) 
0.5 
Germall II (preservative) 
0.2 
Glydant (preservative) 0.3 
______________________________________ 
Carbomer 940 is dispersed in 87 parts water with propeller mixing. The 
ingredients in the moisturizing component are mixed together with 
propeller mixing and the mix is added to the Carbomer 940 solution. 
Triethanolamine is then added to the mixture with sweep mixing until a gel 
forms. The Glydant and Germall II are dissolved in 1.5 parts water and 
this solution is added to the gel with mixing to form the aqueous gel of 
the invention.