ADMINISTRATION DEVICE FOR IN PARTICULAR INTRAVITREAL ADMINISTRATION OF A FLUID

An administration device for intravitreal administration of a fluid wherein a second actuation part of the administration device is configured to axially block a plunger rod and/or a first actuation part of the administration device, where in the second actuation part is to be actuated in order to axially release the plunger rod and/or the first actuation part such that the first actuation part can be actuated. The administration device has a securing member that is configured to block a back-movement of the plunger rod and/or the first actuation part at least in an initial position and/or in an administration position of the plunger rod and wherein the securing member is configured to block actuation of the second actuation part before reaching the administration position of the plunger rod.

BACKGROUND OF THE INVENTION

Field of the Invention

The present invention relates to an administration device for preferably ophthalmic, in particular intravitreal, administration of a fluid.

The present invention relates generally to the field of administration/delivery devices for pharmaceutical administration/delivery of a fluid, in particular a drug, to a patient, i.e. a human or animal.

The administration/delivery device according to the present invention is preferably adapted to deliver, in particular inject, a drug (directly) into the eye, in particular the vitreous, interior and/or posterior chambers of the eye, of a human or animal. Thus, the present invention in particular relates to administration/delivery devices for ophthalmic, in particular intravitreal, injection of a fluid, in particular a drug. However, the administration device according to the present invention can also be used for administration/injection of a fluid, in particular a drug, into other parts of the human or animal body.

Description of the Related Art

International Patent Application Publication WO 2014/005728 A1 relates to a small volume syringe suitable for ophthalmic injections, wherein the syringe is pre-filled with a drug and comprises a body, a stopper and a plunger. The plunger comprises a plunger contact surface arranged to contact the stopper such that the plunger can be used to push the stopper towards an outlet, thereby delivering a fluid contained within the syringe.

SUMMARY OF THE INVENTION

The object of the present invention is to provide an improved—in particular solely mechanical—administration/delivery device which is user-friendly and/or easy, intuitive and/or safe to use and/or minimizes or at least reduces the risk of misapplication, misuse, contamination, incorrect and/or imprecise dosing, and/or of the delivery/administration of air bubbles and/or minimizes or at least reduces the requirements and/or complexity of or within the manufacturing processes of the administration/delivery device.

The above object is achieved by an administration/delivery device as disclosed herein.

The administration/delivery device, hereinafter referred to as administration device, according to the present invention is preferably adapted to (immovably) hold an in particular cylindrical container for a fluid, in particular a drug.

The container is preferably pre-filled with the fluid, in particular a drug.

Preferably, a stopper/piston/plunger, hereinafter referred to as stopper, is movably arranged within the container, in particular such that by an axial movement of the stopper towards the outlet of the container the fluid contained in the container is dispensed.

Preferably, the administration device comprises the container and/or the stopper.

Further, the administration device comprises a retainer/holder, hereinafter referred to as retainer, preferably wherein the container is or can be in particular immovably held/received by and/or at least partially arranged within the retainer.

The administration device comprises an actuation mechanism for actuating the administration device and/or for moving the stopper within the container, in particular for so-called priming of the administration device before administering the fluid and/or for dispensing/administering the fluid out of the container, as will be explained in the following.

The administration device, in particular its actuation mechanism, comprises a plunger/piston/connecting rod—in particular directly and/or axially—acting on the stopper, a first actuation part—in particular directly and/or axially acting on the plunger/piston/connecting rod—and a second actuation part, wherein the second actuation part is movably, in particular rotatably, attached to the retainer and/or wherein the plunger/piston/connecting rod, hereinafter referred to as plunger rod, and/or the first actuation part are/is in particular axially movable, in particular slidable, relative to the retainer and/or container.

Preferably, the plunger rod can be axially moved relative to the retainer and/or container, in particular (further) into the container, by actuating, in particular depressing, the first actuation part, in particular in order to prime the administration device and/or—subsequently to priming—to dispense/administer the fluid out of the container.

The actuation mechanism of the administration device, in particular the first actuation part, is preferably configured to (axially) move, in particular push, the plunger rod and/or the stopper further into the container and/or from an initial/unactuated position to an administration/ready-to-use/primed position during priming, prior to administration and/or by (manually) actuating, in particular depressing, the first actuation part, in particular for the first time, and/or from the administration/ready-to-use/primed position to a final/actuated/end-of-use position after priming, during (subsequent) administration and/or by—in particular manually—actuating the first actuation part, in particular again and/or for the second time.

According to one aspect of the present invention, the second actuation part is configured to axially block—in particular in a form-fitting manner—the plunger rod and/or the first actuation part, in particular from being moved (directly) into the administration/ready-to-use/primed position and/or into the final/actuated/end-of-use position and/or from being (completely) actuated and/or inserted into the container, wherein the second actuation part is to be (manually) actuated, in particular rotated or slided, in order to axially release/unblock the plunger rod and/or the first actuation part, such that the first actuation part can be—in particular partially, completely and/or subsequently—actuated and/or such that the plunger rod and/or the stopper can be moved from the initial/unactuated position to the administration/ready-to-use/primed position and/or from the administration/ready-to-use/primed position to the final/actuated/end-of-use position and/or further into the container.

In this way, an easy, intuitive, and user-friendly usage of the administration device is achieved. In particular, the priming process is clearly separated from the administering process, thereby derisking misuse of the administration device, fluid waste and/or incorrect/imprecise dosing.

Preferably, the second actuation part can be actuated by turning/rotating or sliding the second actuation part relative to the container and/or retainer and/or around the plunger rod, mostly preferred by at least essentially 90 degrees. In this way, the usability is improved and/or the risk of misuse is decreased.

Since the second actuation part is preferably actuated in a direction at least essentially transversal to the direction of actuation of the first actuation part, a possible impact of the actuation of the second actuation part on the first actuation part and/or on the injection side is minimized or at least reduced.

The first actuation part can be actuated by (manually) pushing, in particular depressing, the first actuation part towards the second actuation part and/or towards the retainer.

By actuating, in particular pushing/depressing, the first actuation part and, thereby, moving the plunger rod and/or the stopper, it is possible to (manually) prime the administration device and/or to push out air/gas contained within the container and/or a needle attached thereto.

In the context of the present invention, the term “prime”/“priming” preferably refers to the (necessary) preparation of the administration device (immediately) prior to administration of the fluid contained in the administration device, in particular its container.

Preferably, during priming, the plunger rod is (axially) moved such that and/or until the plunger rod, in particular its front portion and/or tip, abuts the stopper.

Mostly preferred, during priming, the plunger rod is (axially) moved such that the plunger rod, in particular its front portion and/or tip, moves/pushes the stopper—in particular towards an outlet—and/or such that a (small) part of the fluid is dispensed and/or air, i.e. air bubbles contained in the fluid, the container and/or a needle attached thereto, is/are removed, in particular pushed out.

The administration device is preferably held vertically during priming, in particular such that the outlet of the container and/or a needle attached thereto points upwards and/or that air can be at least partially pushed out of the container.

Preferably, the volume contained in the container after priming corresponds to a desired/pre-defined dose to be administered to a patient/user.

Typically, the volume of the fluid contained in the (pre-filled) container exceeds the volume of the dose to be administered so that air contained in the fluid, container and/or the needle attached thereto can be removed at least partially by priming without effecting the dose to be administered.

However, priming of the administration device does not imply that a container is actually filled with a fluid and/or that a part of the fluid is dispensed. In particular, the actuation mechanism, mostly preferred the first actuation part, can also be actuated even if the container is empty and/or without moving and/or acting on the stopper.

In other words, “prime”/“priming” in particular means a movement of the plunger rod and/or the stopper from the initial/unactuated position to a defined position, hereinafter referred to as administration/ready-to-use/primed position, in particular before administering the fluid and/or by (partially) actuating the first actuation part, in particular for the first time.

Accordingly, all actions performed prior to administering the fluid and/or actuating the second actuation part are preferably to be considered as priming and/or the priming process.

Priming is preferably done/completed solely by (partially) actuating, in particular pushing, the first actuation part, mostly preferred manually.

In the context of the present invention, the term “administer”/“administration” preferably relates to the (actual) delivery/dispensing of the fluid from the administration device, preferably its container, mostly preferred through an injection needle attached thereto.

While it is preferred that the administration device according to the present invention is used for administering a fluid, in particular a drug, directly to the body of a patient, e.g., by using an injection needle and/or by injecting a fluid directly into the eye of a patient, in particular the vitreous body, the term “administer” and “administration” also refers to delivery/dispensing the fluid without a patient being present.

Preferably, “administer”/“administration” means and/or includes a movement of the plunger rod and/or the stopper from the administration/ready-to-use/primed position to a final/actuated/end-of-use position, in particular after priming and/or after actuating the first actuation part for the first time, mostly preferred by actuating the first actuation part completely and/or for the second time.

The initial/unactuated position, hereinafter referred to as the initial position, is preferably the (axial) position of the plunger rod and/or the stopper relative to the retainer and/or container before priming of the administration device and/or actuating the first actuation part (for the first time) and/or in the initial state of the administration device.

In the initial state of the administration device and/or when the plunger rod and/or the stopper are/is in the initial position, the first actuation part and the second actuation part are preferably unactuated.

It is preferably only possible to (directly) actuate either the first actuation part or the second actuation part in the initial state of the administration device and/or when the plunger rod and/or the stopper are/is in the initial position.

Mostly preferred, it is only possible to (directly) actuate the first actuation part in the initial state of the administration device and/or when the plunger rod and/or the stopper are/is in the initial position.

Preferably, the second actuation part is blocked in the initial position/state. It is thus preferably not possible to (directly) actuate the second actuation part in the initial state of the administration device and/or when the plunger rod and/or the stopper are/is in the initial position.

The plunger rod and/or the stopper can be moved out of the initial position and/or from the initial position to the administration/ready-to-use/primed position in particular solely by (partially) actuating the first actuation part for the first time.

The administration/ready-to-use/primed position, hereinafter referred to as administration position, is preferably the (axial) position of the plunger rod and/or the stopper relative to the retainer and/or the container (immediately) after priming and/or (immediately) after actuating, in particular pushing/depressing, the first actuation part for the first time and/or before administration is carried out and/or in the primed state of the administration device.

The primed state of the administration device is preferably the state of the administration device immediately after actuating the first actuation part for the first time and/or immediately after reaching the administration position. In the primed state of the administration device, the first actuation part is only partially actuated and/or the second actuation part is (still) unactuated.

In the administration position, the plunger rod and/or the stopper are/is arranged closer to an outlet of the administration device, in particular the container, compared to the initial position.

In particular, the plunger rod and/or the stopper are/is inserted further into the container in the administration position compared to the initial position.

The plunger rod and/or the first actuation part are/is preferably blocked from being completely actuated and/or moved from the initial position directly/continuously to the final position, mostly preferred by means of the second actuation part. With other words, the plunger rod and/or the first actuation part can preferably only be actuated and/or moved directly/continuously from the initial position to the administration position.

Preferably, the second actuation part is configured to axially block/stop the plunger rod and/or the first actuation part in the administration position and/or from being moved directly/continuously from the initial position to the final position.

In the primed state of the administration device and/or immediately after reaching the administration position and/or after (partially) actuating the first actuation part, the administration device, in particular the plunger rod and/or the first actuation part, are/is blocked from further movement/actuation, in particular by means of the second actuation part.

Preferably, the second actuation part is to be actuated after priming and/or after reaching the administration position and/or in the primed state of the administration device in order to unblock the administration device and/or to axially release the plunger rod and/or the first actuation part, in particular such that the first actuation part can be—in particular again and/or completely and/or for the second time—actuated and/or such that the plunger rod can be moved further to the final position and/or such that administration can be carried out.

With other words, the second actuation part is preferably to be actuated in order to switch the state of the administration device, in particular the first actuation part, from a blocked state into the administration/ready-to-use/unblocked state.

In the primed/blocked state and/or immediately after reaching the administration position, the second actuation part is preferably in a blocking position in which the second actuation part axially blocks the plunger rod and/or the first actuation part, mostly preferred such that the first actuation part cannot be further and/or completely actuated.

By actuating, in particular turning/rotating or sliding, the second actuation part, the second actuation part is moved from the blocking position to a releasing position in which the second actuation part axially releases the plunger rod and/or the first actuation part and/or in which the first actuation part can be further and/or completely actuated.

In the administration/ready-to-use/unblocked state of the administration device and/or after actuating the second actuation part, the administration device is ready to use, the first actuation part can be further/completely actuated, the plunger rod can be moved to the final position and/or the fluid can be administered to a patient, in particular without performing further steps apart from actuating the first actuation part.

It is preferably not possible to reverse the actuation of the first actuation part in the administration position/state and/or in the final position/state.

It is preferably not possible to (again) actuate the second actuation part in the initial state/position, during movement of the plunger rod from the initial position to the administration position and/or before reaching the administration position and/or to reverse the actuation of the second actuation part after actuating the second actuation part and/or in the releasing position of the second actuation part.

The final/actuated/end-of-use position, hereinafter referred to as final position, is preferably the (axial) position of the plunger rod and/or the stopper relative to the retainer (immediately) after administration and/or after (completely) actuating the first actuation part, in particular for the second time, and/or in the final/actuated/end-of-use state of the administration device, hereinafter referred to as final state.

In the final state of the administration device and/or when the plunger rod and/or the stopper are/is in the final position, the administration has been carried out and/or the first actuation part is (completely) actuated.

In the final state/position, the plunger rod and/or the stopper are/is arranged closer to the outlet of the administration device compared to the initial state/position and/or the administration position/state.

In particular, no further fluid can be dispensed/administered in the final state and/or after the final position is reached.

It is preferably not possible to (again) actuate and/or reverse the actuation of the first actuation part and/or the second actuation part in the final state and/or after the final position is reached.

Due to the construction of the administration device, in particular the (mechanical) interaction of the parts/components of the administration device, a user/practitioner is guided through the usage of the administration device, thereby reducing the risk of misapplication, misuse, contamination, incorrect and/or imprecise dosing.

According to another aspect of the present invention which can be realized also independently, the administration device, in particular the actuation mechanism, comprises a securing member/part, wherein the securing member/part is configured to (axially) secure the plunger rod and/or the first actuation part and/or to (axially) block a back-movement of the plunger rod and/or the first actuation part, in particular a movement of the plunger rod and/or the first actuation part out of the container and/or in a direction opposite to the direction of actuation, at least in the initial position and/or in the administration position of the plunger rod. Further, the securing member/part is configured to block the second actuation part, in particular actuating/rotating the second actuation part, in the initial position of the plunger rod and/or before, in particular (only) until, reaching the administration position of the plunger rod and/or during priming and/or movement of the plunger rod from the initial position to the administration position.

In this way, the risk of misuse/misapplication of the administration device is reduced.

The securing member/part, hereinafter referred to as securing member, is preferably embodied as an in particular flexible ring that is arranged within a receptacle of the retainer.

Preferably, the securing member is coupled loosely and/or with radial play to the plunger rod in the initial position and/or in the administration position and/or is radially pretensioned against and/or tightly coupled to the plunger rod during movement of the plunger rod from the initial position towards the administration position.

The securing member is preferably configured to (radially) engage the plunger rod and/or to (axially) block the plunger rod and/or the first actuation part, in particular a back-movement of the plunger rod and/or the first actuation part, at least in the initial position and/or in the administration position of the plunger rod.

Additionally, the securing member is preferably configured to (radially) engage the second actuation part and/or to block actuation/rotation of the second actuation part, in particular in the initial position and/or during movement from the initial position to the administration position, mostly preferred only until the plunger rod reaches the administration position.

Preferably, the securing member automatically disengages/unblocks the second actuation part upon actuating the first actuation part, during movement of the plunger rod from the initial position to the administration position, in particular when the administration position is reached and/or after completing priming.

The plunger rod preferably comprises or forms a ramp for the securing member, preferably wherein the ramp is configured to tension/widen the securing member upon actuation of the first actuation part and/or during movement of the plunger rod from the initial position towards the administration position.

The plunger rod preferably comprises an indentation for the securing member.

Mostly preferred, the plunger rod, in particular its indentation, is configured to at least partially, preferably completely, release the securing member and/or to disengage the securing member from the second actuation part upon actuating the first actuation part, during movement of the plunger rod from the initial position to the administration position, in particular when the administration position is reached and/or after completing priming, mostly preferred such that the second actuation part is unblocked and/or can be actuated.

The actuation mechanism of the administration device is preferably configured to move the securing member from an engaging position to a disengaging position, in particular automatically.

The engaging position is preferably the (radial) position of the securing member relative to the second actuation part in the initial position of the plunger rod, during priming of the administration device and/or actuating the first actuation part and/or until reaching the administration position.

In the engaging position, the securing member engages the second actuation part radially and/or blocks rotational actuation of the second actuation part and/or in a direction of actuation.

The disengaging position is preferably the (radial) position of the securing member relative to the second actuation part after priming of the administration device and/or actuating the first actuation part (for the first time) and/or (immediately) after reaching the administration position.

In the disengaging position, the securing member is disengaged from the second actuation part radially and/or no longer blocks rotational actuation of the second actuation part and/or in a direction of actuation.

Thus, the second actuation part cannot be actuated when the securing member is in the engaging position and can only be actuated when the securing member is in the disengaging position.

The securing member is preferably moved from the engaging position to the disengaging position and/or snaps into the indentation of the plunger rod automatically, by spring force and/or suddenly/abruptly and/or audibly.

In this way, an audible/haptic feedback, in particular an audible click, is provided that clearly indicates the end of priming and/or when the administration position is reached.

In the context of the present invention, the term “audible” preferably refers to a sound that can be heard by an average human ear with normal hearing. An audible sound/feedback preferably comprises a sound level above the absolute threshold of hearing.

For example, a sound with frequencies between 0.2 kHz and 5 kHz and a sound pressure between 20 dB and 100 dB is to be considered as audible.

The above-mentioned aspects and features of the present invention and the aspects and features of the present invention that will become apparent from the claims and the following description can in principle be implemented independently from one another, but also in any combination or order.

Further aspects, advantages, features and properties of the present invention will become apparent from the following description of a preferred embodiment in conjunction with the accompanying drawings.

DETAILED DESCRIPTION OF THE INVENTION

In the figures, the same reference signs are used for the same or similar parts and components, resulting in corresponding or comparable properties, features and advantages, even if these properties, features and advantages are not repeatedly described.

In the following, the construction and the components/parts of a proposed administration device100will be explained with reference toFIGS.1to3. The interaction of the components/parts and the operation of the administration device100will be explained with reference toFIGS.4A-4D,5A-5D,6A-6B,7A-7B and8A-8B, wherein—for reasons of simplicity—some reference signs have been omitted although the related features/components/parts are illustrated.

FIG.1is a schematic perspective view of the proposed administration device100in the initial position/state.FIG.2andFIG.3are exploded views of the administration device100from different angles.

The administration device100is of multi-part construction and/or comprises multiple parts/components, preferably wherein some or all parts of the administration device100are connected to each other by means of a snap/clip-on connection and/or in a screwless manner.

The terms “snap”, “clip” and/or “snap/clip-on connection” is preferably understood to refer to an assembly/connection method, wherein at least two parts/components are assembled/connected to one another—in particular in a force-fitting and/or form-fitting manner—using the elasticity/flexibility of the parts/components to be assembled/connected and/or without using (additional) fastening elements, such as nails, screws, bolts or the like.

As best seen inFIGS.2and3, the administration device100preferably comprises a container10, a retainer20and/or an actuation mechanism having a plunger rod40, a first actuation part60, a second actuation part70and/or a securing member90.

Preferably, some or all parts/components of the administration device100, in particular the container10, the retainer20, the plunger rod40, the first actuation part60, the second actuation part70and/or the securing member90are made out of, in particular injection molded from, plastics, mostly preferred polyethylene and/or polypropylene.

The administration device100is preferably elongated and/or shaped as a syringe.

In particular, the administration device100is embodied as a handheld device and/or shaped in such a manner that it ergonomically fits into a user's/practitioner's hand.

The administration device100, in particular the container10, the plunger rod40, the first actuation part60and/or the second actuation part70, is/are preferably at least essentially cylindrical and/or rotationally symmetric.

Preferably, the administration device100, in particular the container10, the plunger rod40, the first actuation part60and/or the second actuation part70, comprises/comprise and/or defines/define a main axis A, in particular wherein the main axis A is a central, longitudinal, symmetry and/or rotation axis of the administration device100, in particular the container10, the plunger rod40, the first actuation part60and/or the second actuation part70, and/or wherein the main axis A centrally runs through the administration device100, in particular the container10, the retainer20, the plunger rod40, the first actuation part60, the second actuation part70and/or the securing member90.

In the following, spatial orientations, positions and/or arrangements, in particular the terms “radial” or “radially” and/or “axial” or “axially”, refer to the main axis A unless otherwise stated.

Preferably, the first actuation part60forms a (first) axial end and/or a rear end and the container10, in particular its tip/outlet, forms a second (axial) end and/or a front end of the administration device100.

In the normal position of use, the administration device100, in particular the container10, preferably points away from a user/practitioner and/or towards a patient and the first actuation part60points towards a user/practitioner and/or away from a patient.

As already noted in the introductory part, the administration device100is adapted to administer/dispense a fluid11, in particular a drug, to a patient, i.e. a human or animal.

Preferably, the container10is pre-filled with the fluid11and/or already contains the fluid11in the initial state of the administration device100.

The administration device100is preferably adapted to administer/dispense the fluid11out of the container10, in particular its outlet, to a patient, mostly preferred by means of its actuation mechanism, as will be explained later in greater detail.

The container10is preferably elongated and/or embodied as a hollow cylinder.

Preferably, the container10comprises a main body12, preferably wherein the main body12is embodied as a hollow cylinder and/or wherein the inner diameter of the main body12is constant over the longitudinal extension of the main body12.

The container10, in particular its main body12, is preferably formed integrally/in one piece. Mostly preferred, the container10, in particular its main body12, is made out of glass or injection molded from plastics.

The container10preferably comprises a first axial end13and a second axial end14.

The first axial end13of the container10is preferably embodied as a flange/collar and/or comprises an enlarged outer diameter compared to the outer diameter of the main body12and/or the second axial end14.

The second axial end14of the container10is preferably embodied as the tip of the container10and/or comprises or forms the outlet of the container10.

As best seen inFIGS.3and4, the second axial end14of the container10is preferably cone-shaped and/or tapered. Mostly preferred, the second axial end14comprises a smaller inner and/or outer diameter compared to the inner and/or outer diameter of the main body12and/or the first axial end13.

Preferably, the second axial end14of the container10is embodied as a connection part for a needle19(not shown inFIGS.1to3).

As shown inFIG.1, the administration device100, in particular the container10, is optionally equipped with a closure/lock15, in particular a Luer lock, in order to protect/seal the administration device100, in particular the container10, mostly preferred its second axial end14, and/or to provide a connection for the needle19.

Preferably, the needle19can be attached to the container10, in particular the second axial end14, by means of the lock15, mostly preferred in a form-fitting and/or force-fitting manner.

The lock15preferably comprises a connector16and/or a cap17, preferably wherein the connector16and/or the cap17are attached to the second axial end14of the container10, in particular in a form-fitting and/or force-fitting manner, and/or wherein the cap17axially covers the second axial end14and/or the connector16, mostly preferred in the initial state of the administration device100.

The connector16is preferably adapted to connect the needle19to the container10, in particular its second axial end14.

In order to connect the needle19to the container10, the cap17can be removed from the container10and/or the connector16. Subsequently, the needle19can be attached to, in particular screwed into, the connector16.

Preferably, the lock15, in particular the connector16, comprises an internal thread such that the needle19can be screwed into the lock15, in particular the connector16. In this way, a particularly firm connection of the needle19and lock15can be achieved. However, other constructional solutions are possible as well.

The administration device100, in particular the container10, preferably comprises a stopper18, preferably wherein the stopper18is movably arranged within the container10, in particular its main body12.

The main body12of the container10and the stopper18preferably delimit a chamber for the fluid11.

The stopper18is preferably made out of, in particular injection molded from, plastic, in particular an elastomer.

The stopper18is preferably cylindrical and/or comprises an outer diameter that corresponds at least essentially to and/or is (slightly) larger than the inner diameter of the container10, in particular the main body12, preferably such that the stopper18presses against the inner wall of the container10, in particular the main body12.

Preferably, the stopper18sealingly abuts the inner wall of the container10, in particular the main body12, and/or comprises or forms at least one (radial) seal, in particular such that the fluid11cannot leak out and/or flow through a gap between the stopper18and the inner wall of the main body12.

By moving/pushing the stopper18towards the second axial end14of the container10, preferably by means of the actuation mechanism, in particular by means of the first actuation part60, the volume of the chamber delimited by the main body12and by the stopper18can be reduced, thereby delivering the fluid11contained in the container10.

As already mentioned, the administration device100preferably comprises the retainer20, preferably wherein some or all parts/components of the administration device100, are (directly) mounted on and/or—in particular either rigidly/immovably or movably—attached to or held by the retainer20.

Thus, the retainer20preferably functions as a supporting/connecting/mounting structure for the other parts/components of the administration device100, in particular the container10, the plunger rod40, the first actuation part60, the second actuation part70and/or the securing member90.

Preferably, the container10is rigidly/immovably held by and/or attached to the retainer20.

Preferably, the plunger rod40, the first actuation part60, the second actuation part70and/or the securing member90are/is movably attached to the retainer20, as will be explained later in further detail.

The mount/receptacle/socket21, hereinafter referred to as mount21, and the support/holder/frame22, hereinafter referred to as support22, are preferably made out of the same material and/or formed, in particular injection molded, in one piece and/or from plastic.

The retainer20, in particular the mount21, is preferably adapted to immovably hold the container10, preferably in a clamped manner and/or in particular in such a way that the container10is radially and axially held within and/or by means of the retainer20, in particular the mount21.

The container10, in particular its first axial end13, is preferably radially/laterally inserted, in particular pressed/clipped, into the retainer20, mostly preferred the mount21.

To this end, the inner shape/contour of the mount21preferably corresponds at least essentially to the outer shape/contour of the container10, in particular its first axial end13.

The mount21is preferably slot-shaped and/or comprises a radial opening21A and/or an axial opening21B, preferably wherein the container10, in particular its axial end13, is radially (inserted), in particular pressed/clipped, into the mount21via radial opening21A and/or wherein the main body12of the container10extends out of the mount21via axial opening21B.

The retainer20, in particular the support22, is preferably adapted to (axially) receive and/or (radially) support/guide the plunger rod40, the first actuation part60, the second actuation part70and/or the securing member90, in particular such that the second actuation part70can be rotated relative to the retainer20and/or is axially held by the retainer20, in particular the support22, and/or such that the plunger rod40and/or the first actuation part60can axially move relative to and/or through the retainer20, in particular the support22, as will be explained in the following.

The plunger rod40, the first actuation part60, the second actuation part70and/or the securing member90are/is preferably axially attached to and/or inserted into the retainer20, mostly preferred the support22.

The retainer20, in particular the support22, preferably comprises or forms an in particular at least essentially cylindrical socket/receptacle22A for the securing member90and/or the second actuation part70, preferably wherein the support22, in particular the socket/receptacle22A is axially open.

The retainer20, in particular the support22, preferably comprises an in particular ring-shaped wall22B, preferably wherein the wall22B defines and/or radially delimits the socket/receptacle22A, hereinafter referred to as receptacle22A.

Preferably the support22, in particular the wall22B is radially open and/or comprises a radial opening22C.

The securing member90is preferably inserted into the receptacle22A and/or is radially surrounded by the wall22B.

It is preferred that the securing member90radially protrudes out of the receptacle22A and/or through the radial opening22C, as will be explained later in further detail.

The mount21and the support22are preferably arranged on opposite sides of the retainer20.

The retainer20preferably comprises an intermediate/separating wall23, hereinafter referred to as intermediate wall23, preferably wherein the intermediate wall23is arranged between the mount21and the support22and/or (axially) separates the mount21from the support22.

In particular, the intermediate wall23axially delimits the mount21towards the support22, in particular the receptacle22A, and/or axially delimits the support22, in particular the receptacle22A, towards the mount21.

The retainer20, in particular the intermediate wall23, preferably comprises an in particular cross-shaped opening/aperture24for the plunger rod40, preferably wherein the plunger rod40extends through the opening/aperture24of the retainer20.

In particular, the opening/aperture24, hereinafter referred to as aperture24, preferably guides the plunger rod40radially and/or prevents or delimits a potential rotation of the plunger rod40relative to the retainer20.

The administration device100, in particular the retainer20, preferably comprises a finger flange/collar25, preferably wherein the finger flange/collar25radially extends outwards from the retainer20.

The finger flange/collar25, hereinafter referred to as finger flange25, is preferably embodied as a preferably oval disk extending around mount21, support22, intermediate wall23and/or aperture24. However, other constructional solutions are possible as well.

The securing member90is preferably at least essentially ring-shaped and/or surrounds/encloses the plunger rod40radially.

In particular, the plunger rod40axially extends through the securing member90.

As already mentioned, the securing member90is preferably configured to secure the plunger rod40, the first actuation part60and/or the second actuation part70. Preferably, the securing member90is configured to block a back-movement of the plunger rod40and/or the first actuation part60. Further, the securing member90is preferably configured to block actuation of the second actuation part70.

The securing member90preferably comprises at least one return stop91/92, preferably wherein the return stop91/92is adapted to (radially) engage and/or (axially) block the first actuation part60and/or the plunger rod40, at least in the initial position and/or the administration position of the plunger rod40.

The return stop91/92is preferably embodied as a protrusion extending radially inwards and/or towards the plunger rod40. Mostly preferred, the return stop91/92is hook-like and/or embodied as a latch.

In the present embodiment, the securing member90comprises a first return stop91and a second return stop92, preferably wherein the first return stop91and the second return stop92are arranged on opposite sides of the securing member90and/or (radially) engage the plunger rod40from different, in particular opposite, sides.

Preferably, the securing member90, in particular the return stop91/92, is radially pretensioned against the plunger rod40.

The securing member90is preferably compressible and/or stretchable and/or embodied as a spring.

The securing member90preferably comprises an (integrated) spring element93/94, preferably wherein the spring element93/94is adapted to (radially) press the return stop91/92against the plunger rod40.

The spring element93/94is preferably elastic/bendable/flexible, in particular such that the securing member90can be compressed or stretched.

The spring element93/94preferably connects the first return stop91and the second return stop92.

The spring element93/94is preferably curved and/or arch-shaped. Mostly preferred, the spring element93/94is bent/curved around the plunger rod40.

In the present embodiment, the securing member90comprises a first spring element93and a second spring element94, preferably wherein the first spring element93and the second spring element94are arranged on opposite sides of the securing member90and/or around the plunger rod40and/or (each) connect the first return stop91and the second return stop92.

As already mentioned, the securing member90is preferably configured to radially engage the second actuation part70and/or block actuation of the second actuation part70.

The securing member90preferably comprises a blocking element95, preferably wherein the blocking element95is configured to block rotational actuation of the second actuation part70and/or in a direction of actuation and/or to (radially) engage the second actuation part70, in particular only during priming and/or only until the plunger rod40reaches the administration position, as will be explained later in further detail.

The blocking element95is preferably embodied as a protrusion/bulge extending radially outwards and/or away from the plunger rod40and/or towards the second actuation part70. Preferably, the blocking element95radially extends through the radial opening22C of the retainer20, in particular the support22, in particular such that the blocking element95radially engages the second actuation part70.

The second actuation part70is preferably configured to axially block the plunger rod40and/or the first actuation part60, in particular when the administration position is reached and/or after completing priming of the administration device100.

In particular, the second actuation part70is configured to prevent that the plunger rod40is (directly) moved from the initial position to the final position and/or that the first actuation part60is completely actuated, as will be explained later in greater detail.

The second actuation part70is preferably at least essentially cylindrical and/or cap-like and/or embodied as a hollow cylinder.

The second actuation part70preferably comprises an outer part71and/or an inner part72, preferably wherein the outer part71and/or the inner part72are/is at least essentially cylindrical and/or embodied as a hollow cylinder and/or wherein the inner part72is arranged within the outer part71and/or wherein the outer part71encloses the inner part72.

The second actuation part70is preferably arranged between the container10and the first actuation part60.

Preferably, the second actuation part70is (directly) attached, in particular axially secured, to the retainer20, in particular the support22, mostly preferred the wall22B.

Preferably, the second actuation part70, in particular its outer part71, covers the support22, in particular the wall22B, and/or the securing member90radially and/or to the outside.

The second actuation part70, in particular its outer part71, preferably comprises or forms a handle/dial.

Preferably, the second actuation part70, in particular its outer part71, is axially attached, in particular pressed/clipped into or onto, the retainer20, in particular the support22, mostly preferred the wall22B.

Preferably, the second actuation part70, in particular the outer part71, comprises a plurality of retaining elements73that radially engage and/or protrude and/or are snapped into the retainer20, in particular the support22, mostly preferred the wall22B and/or a corresponding retaining element22D, e.g. a protrusion and/or recess formed in the wall22B, in particular such that the second actuation part70is axially secured to the retainer20, in particular the support22.

However, it is preferred that the second actuation part70can be moved, in particular rotated, relative to the retainer20, preferably in a preferred/intended direction of rotation, hereinafter referred to as direction of actuation.

Preferably, the actuation mechanism, in particular the second actuation part70, can be actuated by manually rotating the second actuation part70relative to the retainer20.

In order to facilitate rotation of the second actuation part70, the outer surface of the second actuation part70, in particular the outer part71, might be at least partially grooved, ripped and/or otherwise profiled.

The administration device100, in particular the actuation mechanism and/or the second actuation part70, preferably comprises/defines a rotation axis, preferably wherein the second actuation part70is rotatable about the rotation axis.

The rotation axis preferably corresponds to/coincides with the main axis A of the administration device100. However, other solutions are possible as well, wherein the rotation axis differs from the main axis A.

It is preferred that the second actuation part70can be rotated only in the direction of actuation and/or in that the administration device100, in particular the retainer20, comprises a back-rotation lock, in particular a ratchet, for the second actuation part70.

The direction of actuation might be indicated on the second actuation part70and/or the retainer20, mostly preferred the finger flange25, by means of a label, a mark or the like.

The second actuation part70, in particular its outer part71, preferably comprises or forms a back-rotation stop74/75and/or an actuation stop76, preferably wherein the back-rotation stop74/75is configured to prevent or limit/block back-rotation of the second actuation part70, i.e. in a direction opposite to the (intended) direction of actuation, and/or wherein the actuation stop76is configured to limit/block the actuation, in particular rotation, of the second actuation part70relative to the retainer20, in particular in the (intended) direction of actuation.

The retainer20, in particular the support22, preferably comprises or forms a (corresponding) back-rotation stop26and/or an actuation stop27, preferably wherein the back-rotation stop74/75of the second actuation part70and the back-rotation stop26of the retainer20interact with one another, in particular in such a manner that only a rotation of the second actuation part70in the (intended) direction of actuation is possible and/or such that a back-rotation of the second actuation part70, i.e. in a direction opposite to the (intended) direction of actuation, is prevented or limited.

In particular, the back-rotation stop26of the retainer20and the back-rotation stop74/75of the second actuation part70engage one another in a form-fitting manner in a direction opposite to the (intended) direction of actuation and/or glide past each other, i.e. by elastically/temporarily deforming/bending of the back-rotation stop74/75of the second actuation part70and/or the back-rotation stop26of the retainer20, in the (intended) direction of actuation.

The second actuation part70, in particular its outer part71, preferably comprises or forms a first back-rotation stop74and a second back-rotation stop75, preferably wherein the first back-rotation stop74and the second back-rotation stop75are circumferentially spaced apart from one another and/or engage/abut the back-rotation stop26of the retainer20at different rotary positions/orientation of the second actuation part70. Mostly preferred, the first back-rotation stop74engages/abuts the back-rotation stop26of the retainer20before actuating the second actuation part70and the second back-rotation stop75engages/abuts the back-rotation stop26of the retainer20after actuating the second actuation part70, in particular in a direction opposite to the direction of actuation and/or in a form-fitting manner.

The actuation stop76of the second actuation part70and the actuation stop27of the retainer20preferably engage one another in a form-fitting manner at the end of actuation of the second actuation part70and/or when a predefined/final rotary orientation/position of the second actuation part70is reached, in particular such that further actuation of the second actuation part70is prevented/blocked.

The actuation stop76of the second actuation part70preferably abuts/hits the actuation stop27of the retainer20in a circumferential direction at the end of actuation of the second actuation part70and/or when a predefined/final rotary orientation of the second actuation part70is reached, in particular when reaching the releasing position, as will be explained later in further detail.

As best seen inFIG.2, the back-rotation stop(s)74/75and/or the actuation stop76are/is preferably embodied as a preferably longitudinal protrusion, respectively, in particular a rib, protruding from the outer part71of the second actuation part70radially into the interior of the second actuation part70, towards the support22and/or wall22B of the retainer20.

As best seen inFIG.3, the back-rotation stop26and/or the actuation stop27are/is preferably embodied as or formed by a protrusion/bulge protruding from the support22and/or wall22B radially towards the second actuation part70, in particular the outer part71.

As already mentioned, the inner part72of the second actuation part70is preferably embodied as a hollow cylinder arranged within and/or surrounded by the outer part71.

The second actuation part70, in particular the inner part72, is preferably adapted to (radially) guide the plunger rod40and/or the first actuation part60.

In particular, the second actuation part70, mostly preferred the inner part72, is configured to limit/block actuation of the first actuation part60and/or the (axial) movement of the plunger rod40relative to, in particular towards, the retainer20and/or the container10.

The second actuation part70, in particular the inner part72, preferably comprises a blocking wall77and/or an in particular slot-shaped opening/aperture78, preferably wherein the opening/aperture78is formed within the blocking wall77.

Preferably, the plunger rod40and/or the first actuation part60extend/extends through the second actuation part70, in particular the inner part72, mostly preferred opening/aperture78.

The opening/aperture78, hereinafter referred to as opening78, preferably guides the plunger rod40radially.

The shape/contour of the opening78preferably correspond at least essentially to the (outer) shape/contour of the plunger rod40.

As best seen inFIG.2, the opening78is preferably at least essentially slot-like.

Mostly preferred, the plunger rod40can only be moved/pushed through opening78when a predefined rotary orientation of the second actuation part70, in particular the opening78, relative to the plunger rod40and/or the retainer20is reached. With other words, the actuation of the first actuation part60and/or the movement of the plunger rod40depends on the rotational position of the second actuation part70, in particular its opening78, relative to the retainer20, the first actuation part60and/or the plunger rod40.

The plunger rod40is preferably adapted to (directly) act on and/or abut the stopper18. In particular, the plunger rod40is adapted to push the stopper18towards the outlet of the container10and/or to push fluid11out of the container10, in particular by actuating the first actuation part60.

However, it is preferred that the stopper18is not rigidly attached to the plunger rod40, in particular its tip. Preferably, the stopper18merely rests against and/or is loosely connected to the plunger rod40, in particular its tip.

With other words, the plunger rod40and/or the stopper18are configured to connect merely in compression and/or when the plunger rod40is pushed against the stopper18. The plunger rod40and the stopper18are preferably configured to decouple in tension and/or when the plunger rod40is moved/pulled out of the container10. This prevents drawing air into the container10, for example during a sterilizing process of the administration device100.

In the initial state of the administration device100and/or in the initial position of the plunger rod40, the stopper18might also be axially spaced apart from the plunger rod40, such that the plunger rod40axially abuts the stopper18only upon actuation of the first actuation part60.

Preferably, the plunger rod40extends (completely) axially through the administration device100, preferably the second actuation part70, the securing member90and/or the retainer20, mostly preferred from the first actuation part60through the second actuation part70, the securing member90and the retainer20into the container10.

The plunger rod40preferably comprises a front part/portion41, an intermediate part/portion42and/or a rear part/portion43, preferably wherein the intermediate part/portion42is (axially) arranged between the front part/portion41and the rear part/portion43.

The plunger rod40, in particular the front, intermediate and rear part/portion41,42,43, is preferably integrally formed or formed as one piece.

The front part/portion41, hereinafter referred to as front portion41, preferably comprises or forms the (first) axial end and/or the tip of the plunger rod40.

The front portion41is preferably the portion of the plunger rod40that at least partially extends into the container10and/or (directly) faces/abuts the stopper18.

The rear part/portion43, hereinafter referred to as rear portion43, preferably comprises or forms a (second) axial end of the plunger rod40. Preferably, the rear portion43faces away from the stopper18.

Preferably, the first actuation part60is directly and/or rigidly connected to the plunger rod40, in particular its rear portion43. The first actuation part60might be formed by the rear portion43of the plunger rod40and/or integrally/as one piece with the plunger rod40, in particular the rear portion43.

The first actuation part60is preferably at least essentially plate-shaped, collar-like and/or flange-like and/or comprises an enlarged outer diameter compared to the outer diameter of the plunger rod40, in particular its rear portion43. Mostly preferred, the first actuation part60comprises or forms a thumb-rest.

By actuation, in particular depressing, of the first actuation part60, in particular towards the second actuation part70and/or the retainer20and/or in the direction of actuation, the plunger rod40, in particular its front portion41, is preferably moved, in particular pushed, towards the outlet of the container10and/or further into the container10.

By actuation, in particular depressing, of the first actuation part60, in particular towards the second actuation part70and/or the retainer20and/or in the direction of actuation, the plunger rod40, in particular its intermediate part/portion42, is preferably moved, in particular pushed, through the second actuation part70, the securing member90and/or the retainer20.

Preferably, the direction of movement of the plunger rod40corresponds/coincides with the direction of actuation of the first actuation part60and/or is parallel to, in particular along, the main axis A.

The plunger rod40, in particular its intermediate part/portion42, hereinafter referred to as intermediate portion42, is preferably adapted to mechanically interact with the actuation mechanism, the second actuation part70and/or the securing member90, as will be explained later with greater detail.

The plunger rod40, in particular the front portion41and/or the intermediate portion42, preferably comprises an at least essentially cross-shaped cross section.

Preferably, the plunger rod40, in particular the front portion41and/or the intermediate portion42, comprise/comprises a cross section that varies along the main axis A.

The dimensions of the plunger rod40, in particular the front portion41and/or the intermediate portion42, are preferably smaller than the inner diameter of the container10, in particular its main body12, preferably such that the plunger rod40can move freely and/or within the container10.

The rear portion43of the plunger rod40is preferably the portion of the plunger rod40that projects out of the container10and/or forms the transition to the first actuation part60.

The plunger rod40, in particular the front portion41and/or the intermediate portion42, preferably comprise/comprises a plurality of, in particular four, wings/sides/rips44-47, preferably wherein the wings/sides/rips44-47extend along the main axis A of the plunger rod40and/or project/protrude radially outwards and/or form the cross section of the plunger rod40.

Preferably, the wings/sides/rips44-47, hereinafter referred to as sides44-47, are positioned/arranged/offset by at least essentially 90 degrees to one another and/or around the main axis A.

Preferably, the shape, in particular the height, of some or all sides44-47varies along the main axis A of the plunger rod40and/or in the direction of actuation.

Preferably, the plunger rod40, in particular the front portion41and/or the intermediate portion42, mostly preferred the sides44-47, comprise/comprises indentations, projections, bulges, steps, inclinations or the like.

In the present embodiment, the plunger rod40, in particular the front portion41and/or the intermediate portion42comprise/comprises a first side44, a second side45, a third side46and/or a fourth side47, preferably wherein the first side44and the second side45are arranged on opposite sides of the plunger rod40and/or the third side46and the fourth side47are arranged on opposite sides of the plunger rod40.

The plunger rod40, preferably the front portion41, preferably comprises or forms at least one guide support44A/45A, preferably wherein the guide support44A/45A is embodied as a bulge and/or comprises an increased height compared to the areas immediately adjacent to the guide support44A/45A.

As best seen inFIGS.4A and5A, the guide support44A/45A preferably rests against and/or abuts the inner wall of the container10, in particular its main body12.

Preferably, the guide support44A/45A increases the cross section of the plunger rod40in such a way that the plunger rod40(locally) fits closely and/or abuts the container10, in particular its main body12.

Preferably, the plunger rod40, in particular the front portion41, comprises a first guide support44A and a second guide support45A, preferably wherein the first guide support44A and the second guide support45A are arranged on opposite sides of the plunger rod40and/or are axially offset to one another, in particular such that tilting of the plunger rod40relative to the container10is prevented or at least reduced.

Mostly preferred, the first guide support44A is formed by and/or arranged on the first side44and the second guide support45A is formed by and/or arranged on the second side45.

The plunger rod40, in particular the intermediate portion42, preferably comprises or forms a return stop44B/45B, preferably wherein the return stop44B/45B is formed by a (radial) step/protrusion of the plunger rod40, in particular its intermediate portion42.

The return stop44B/45B is preferably configured to interact with (axially) abuts and/or (radially) engage the securing member90, in particular its return stop91/92.

In particular, the return stop91/92of the securing member90and the return stop44B/45B of the plunger rod40engage one another in a form-fitting manner in a direction opposite to the (intended) direction of movement/actuation of the plunger rod40and/or glide past each other, e.g. by elastically/temporarily deforming/bending the securing member90, in particular its return stop91/92, and/or the return stop44B/45B of the plunger rod40, in the (intended) direction of movement/actuation, in particular such that a back-movement of the plunger rod40out of the container10and/or in a direction opposite to the direction of actuation is blocked/prevented.

The plunger rod40, in particular the intermediate portion42, preferably comprises a first return stop44B and a second return stop45B, preferably wherein the first return stop44B and the second return stop45B are arranged on opposite sides of the plunger rod40, in particular the intermediate portion42, and/or wherein the first return stop44B and the second return stop45B are axially offset to one another.

The first return stop44B is preferably arranged closer to the front portion41and/or the tip of the plunger rod40than the second return stop45B.

The first return stop44B is preferably arranged on and/or formed by the first side44and the second return stop45B is preferably arranged on and/or formed by the second side45of the plunger rod40.

As already mentioned, the plunger rod40, in particular its intermediate portion42, is preferably moved through the securing member90by actuating the first actuation part60.

Preferably, the plunger rod40, in particular its intermediate portion42, mechanically interacts with the securing member90when being moved, in particular pushed, through the securing member90.

Preferably, the first return stop44B of the plunger rod40is configured to (radially) engage the first return stop91of the securing member90and the second return stop45B of the plunger rod40is configured to (radially) engage the second return stop92of the securing member90.

In particular, the first return stop44B of the plunger rod40(radially) engages the securing member90, in particular its first return stop91, in the initial position of the plunger rod40and the second return stop45B of the plunger rod40(radially) engages the securing member90, in particular its second return stop92, in the administration position of the plunger rod40.

The securing member90, in particular its first return stop91(radially) engages, in particular is snapped into, the plunger rod40, in particular the first return stop44B, mostly preferred in the initial position of the plunger rod40and/or such that a back-movement of the plunger rod40out of the container10and/or in a direction opposite to the direction of actuation is blocked/prevented.

The securing member90, in particular its second return stop92, is preferably configured to (radially) engage, in particular snap into, the plunger rod40, in particular the second return stop45B, mostly preferred when the administration position of the plunger rod40is reached and/or such that a back-movement of the plunger rod40out of the container10and/or in a direction opposite to the direction of actuation is blocked/prevented.

The plunger rod40, in particular the intermediate portion42, mostly preferred the first side44, preferably comprises or forms an inclination/ramp44C, preferably wherein the inclination/ramp44C, hereinafter referred to as ramp44C, is arranged and/or starts (axially) between the first return stop44B and the second return stop45B and/or wherein the ramp44C (axially) adjoins the first return stop44B and/or (axially) extends beyond the second return stop45B.

Preferably, the ramp44C continuously increases the cross section of the plunger rod40, in particular the intermediate portion42, towards the rear portion43/first actuation part60. In particular, the plunger rod40, mostly preferred the ramp44C, is configured to stretch/widen and/or press apart the securing member90, in particular when being moved through the securing member90and/or from the initial position to the administration position.

Preferably, the ramp44C is arranged on or formed by the first side44.

Preferably, the shape, in particular the height of the second side45is constant/uniform in the area opposite to the ramp44, mostly preferred such that the cross section of the plunger rod40is (only) increased due to the ramp44C.

The plunger rod40, in particular the intermediate portion42, preferably comprises or forms an actuation stop46A/47A/44D/45D to control, in particular (temporarily) interrupt and/or end, actuation of the first actuation part60and/or movement of the plunger rod40. Preferably, the plunger rod40, in particular the intermediate portion42, preferably comprises or forms a plurality of actuations stops46A/47A and44D/45D axially offset to one another.

The plunger rod40, in particular the intermediate portion42, preferably comprises or forms an actuation intermediate stop46A/47A and/or an actuation end stop44D/45D, preferably wherein the actuation intermediate stop46A/47A and/or the actuation end stop44D/45D are/is formed by a (radial) step/protrusion and/or an (sharp) edge/enlargement of the plunger rod40, in particular the intermediate portion42, mostly preferred its cross section.

The actuation intermediate stop46A/47A and/or the actuation end stop44D/45D are/is preferably configured to axially block the plunger rod40from being further/completely inserted into the container10. Preferably, the actuation intermediate stop46A/47A and/or the actuation end stop44D/45D are/is configured to axially engage/hit/abut the second actuation part70, in particular its inner part72, mostly preferred the blocking wall77, in pre-defined positions of the plunger rod40relative to the second actuation part70, mostly preferred in the administration position and/or in the final position.

The actuation intermediate stop46A/47A is preferably arranged axially in front of the actuation end stop44D/45D (in the direction of actuation/movement) and/or between the second return stop45B and the actuation end stop44D/45D.

With other words, the actuation intermediate stop46A/47A preferably (axially) engages the second actuation part70, in particular its blocking wall77, before the actuation end stop44D/45D when actuating the first actuation part60.

Preferably, the third side46and/or the fourth side47of the plunger rod40comprise/comprises or form/forms the actuation intermediate stop46A/47A.

In the present embodiment, the plunger rod40, in particular the intermediate portion42, comprises two actuation intermediate stops46A and47A arranged on opposite sides of the plunger rod40, preferably wherein the third side46comprises or forms the first actuation intermediate stop46A and the fourth side47comprises or forms the second actuation intermediate stop47A.

Preferably, the first side44and/or the second side45of the plunger rod40comprise/comprises or form/forms the actuation end stop44D/45D.

In the present embodiment, the plunger rod40, in particular the intermediate portion42, comprises two actuation end stops44D and45D arranged on opposite sides, preferably wherein the first side44comprises or forms the first actuation end stop44D and the second side45comprises or forms the second actuation end stop45D.

In the following, different states of the administration device100and the interaction between the parts/components of the administration device100during use will be explained with reference toFIGS.4A-4D,5A-5D,6A-6B,7A-7B and8A8B.

FIG.4A-4Dshow a section of the administration device100in different positions/states, respectively.FIGS.5A-5Dcorrespond toFIGS.4A-4Dand show the administration device100in a section which is rotated by 90° with respect to the correspondingFIGS.4A-4D.

FIGS.4A and5Ashow the administration device100in the initial position/state, i.e. before actuating the first actuation part60for the first time.FIGS.4B and5Bshow the administration device100in the administration position/state, i.e. after (partially) actuating the first actuation part60for the first time and before administering the fluid11, the second actuation part70being (still) unactuated and blocking the first actuation part60from being further/completely actuated.FIGS.4C and5Cshow the administration device100in the administration position/state after actuating the second actuation part70such that the first actuation part60can be actuated for the second time.FIGS.4D and5Dshow the administration device100in the final position/state in which the first actuation part60has been completely actuated, i.e. after administering the fluid11.

FIG.6Ashows the administration device100in the initial position/state, i.e. before actuating the first actuation part60for the first time, the securing member90being in the engaging position and preventing actuation of the second actuation part70.FIG.6Bshows the administration device100in the administration position/state, i.e., after (partially) actuating the first actuation part60, the securing member90being in the disengaging position such that the second actuation part70can be actuated.

FIG.7Ais a schematic cross section of the administration device100in the administration position/state, i.e., after (partially) actuating the first actuation part60, the second actuation part70being (still) unactuated.FIG.7Bis a schematic cross section of the administration device100in the administration position/state after actuating the second actuation part70.

FIG.8Ais a perspective partial section of the administration device100in the administration position/state according toFIG.7A.FIG.8Bis a perspective partial section of the administration device100in the administration position/state according toFIG.7B.

The initial position is preferably the (axial) position of the plunger rod40and/or the stopper18relative to the retainer20and/or container10before actuating the first actuation part60and/or the second actuation part70and/or before priming of the administration device100and/or in the initial state of the administration device100.

In the initial state of the administration device100and/or when the plunger rod40and/or the stopper18are/is in the initial position, the first actuation part60and the second actuation part70are preferably unactuated.

In the initial position/state, the plunger rod40, in particular its rear portion43, axially protrudes out of the retainer20and/or the second actuation part70.

It is preferably not possible to (directly) actuate the second actuation part70and/or to (directly) administer the fluid11in the initial state of the administration device100and/or when the plunger rod40and/or the stopper18are/is in the initial position.

Preferably, only the first actuation part60is (partially) actuatable in the initial state/position. The second actuation part70is preferably not actuatable in the initial state/position.

In the initial position/state, the second actuation part70is preferably blocked rotationally and/or in the direction of actuation, mostly preferred by means of the securing member90.

However, other solutions are possible as well, wherein it is not possible to (directly) actuate the first actuation part60and/or wherein only the second actuation part70is (partially) actuatable in the initial state/position. In particular, the second actuation part70can be configured to axially block the plunger rod40and/or the first actuation part60in the initial position/state and/or is preferably to be actuated, in particular (partially) turned/rotated relative to the retainer20and/or around the plunger rod40, in order to release the plunger rod40and/or such that the first actuation part60can be actuated, in particular for the first time.

As best seen inFIG.4A, the plunger rod40is preferably axially secured from being pulled out in the initial state/position, preferably by means of the securing member90.

In particular, the securing member90is configured to block a back-movement of the plunger rod40and/or the first actuation part60in the initial state/position.

Preferably, the securing member90, in particular its first return stop91, (axially) abuts and/or (radially) engages the plunger rod40, in particular the first return stop44B of the plunger rod40, in the initial state/position, mostly preferred such that a back-movement of the plunger rod40and/or a movement of the plunger rod40out of the container10is blocked.

As already mentioned, it is preferably not possible to (directly) actuate the second actuation part70in the initial state/position, during actuating the first actuation part60and/or during movement of the plunger rod40and/or the stopper18from the initial position to the administration position.

Preferably, the second actuation part70is blocked, in particular rotationally and/or in the direction of actuation, in the initial state/position, during actuating the first actuation part60and/or during movement of the plunger rod40and/or the stopper18from the initial position to the administration position and/or before reaching the administration position of the plunger rod40, mostly preferred by means of the securing member90, in particular its blocking element95.

As best seen inFIG.6A, the securing member90, in particular the blocking element95, preferably (radially) engages the second actuation part70in the initial state/position, during actuating the first actuation part60and/or during movement of the plunger rod40and/or the stopper18from the initial position to the administration position and/or before reaching the administration position.

Preferably, the securing member90, in particular its blocking element95, extends through the wall22B and/or the radial opening22C of the support22and/or protrudes out of the wall22B and/or the radial opening22C of the support22, in particular such that the second actuation part70is blocked from being actuated/rotated and/or in the direction of actuation/rotation.

As best seen inFIG.7A, the second actuation part70is preferably (also) blocked in a direction opposite to the direction of actuation in the initial state/position.

Preferably, the retainer20, in particular the back-rotation stop26, (circumferentially) abuts/blocks and/or (radially) engages the second actuation part70, in particular the first rotation stop74thereof, in a direction opposite to the direction of actuation and/or such that back-rotation is prevented in the initial state/position.

It is thus preferred that the position and/or angle of rotation of the second actuation part70is at least essentially fixed or limited, in particular in the direction of actuation and in the direction opposite to the direction of actuation,—in the initial state/position and/or during movement of the stopper18and/or the plunger rod40from the initial position to the administration position—and/or before reaching the administration position by means of the securing member90, in particular its blocking element95, and by means of the retainer20, in particular its back-rotation stop26.

The first actuation part60can be manually actuated in order to axially move the plunger rod40relative to the retainer20and/or the container10, in particular from the initial position to the administration position in a first step and/or for priming of the administration device100and/or—in particular subsequently and/or after actuating the second actuation part70—from the administration position to the final position in a second step and/or for administering the fluid11, mostly preferred by pushing, in particular depressing, the first actuation part60towards the second actuation part70and/or the retainer20.

By actuating, in particular depressing, the first actuation part60, the stopper18and/or the plunger rod40can be moved, in particular pushed, out of the initial position, in particular from the initial position to the administration position, and/or—in particular subsequently and/or after actuating the second actuation part70—from the administration position to the final position.

FIGS.4B,5B and6Bshow the administration device100in the administration position after (partially) actuating the first actuation part60for the first time and before actuating the second actuation part70.

By actuating, in particular depressing, the first actuation part60, the plunger rod40, in particular the intermediate portion42, mostly preferred its ramp44C, is moved, in particular pushed, through the securing member90, thereby (further) tensioning/widening the securing member90and/or pressing the first return stop91radially outwards and/or pressing apart the first return stop91and the second return stop92, in particular such that the securing member90is (further) pretensioned against the plunger rod40during movement of the plunger rod40from the initial position towards the administration position.

The plunger rod40, in particular the second side45, comprises an indentation45C, preferably wherein the indentation45C forms the second return stop45B.

When reaching the administration position and/or at the end of the priming process and/or when the indentation45C and/or the second return stop45B is pushed/arranged directly adjacent to and/or at the same (axial) level as the securing member90, the (tensioned) securing member90can/is at least partially, preferably completely, relax/released and/or the securing member90, in particular its second return stop92, (automatically) engages and/or snaps into the plunger rod40, in particular its second return stop45B and/or the indentation45C.

In this way, the securing member90, in particular its second return stop92, preferably (radially) engages the plunger rod40, in particular its second return stop45B and/or indentation45C, preferably automatically and/or by spring force, mostly preferred such that a back-movement of the plunger rod40and/or a movement of the plunger rod40out of the container10is prevented/blocked in the administration position.

Additionally, or alternatively, the securing member90, in particular its blocking element95, (radially) disengages and/or (rotationally) releases the second actuation part70, preferably automatically and/or by spring force, mostly preferred such that the second actuation part70can be actuated, in particular for the first time.

Thus, when reaching the administration position, at the end of the priming process and/or when the indentation45C and/or the second return stop45B is pushed directly adjacent to the securing member90, the securing member90, in particular its second return stop92, (automatically and/or audibly) engages and/or snaps into the plunger rod40, in particular its second return stop45B and/or the indentation45C, in particular such that the securing member90(radially) engages and/or (axially) blocks/secures the plunger rod40(in a direction opposite to the direction of actuation) and, further, (radially) disengages and/or (rotationally) releases the second actuation part70.

With other words, by actuating the first actuation part60for the first time and/or during movement of the plunger rod40from the initial position to the administration position, the securing member90, in particular its spring elements93/94, is first tensioned and subsequently and/or when reaching the administration position—in particular suddenly/abruptly and/or audibly—at least partially, preferably completely, released/relaxed.

In this way, the securing member90is (automatically) moved from the engaging position to the disengaging position, the second actuation part70is (automatically) released/unblocked and/or the plunger rod40is (automatically) secured (in the direction opposite to its direction of actuation/movement).

Preferably, an audible/haptic feedback is provided that clearly indicates the end of priming and/or when the administration position is reached.

The administration position is preferably the (axial) position of the stopper18and/or the plunger rod40relative to the retainer20and/or the container10after completing the priming process and/or after actuating, in particular depressing, the first actuation part60, in particular partially and/or for the first time.

As already mentioned, the second actuation part70is preferably configured to axially block the plunger rod40and/or the first actuation part60(in the direction of actuation) and/or to prevent complete actuation of the first actuation part60and/or complete insertion of the plunger rod40into the container10, in particular when the administration position is reached.

The first actuation part60can only be (initially) actuated and/or the plunger rod40can only be (initially) moved until the second actuation part70axially blocks the first actuation part60and/or the plunger rod40. With other words, the first actuation part60can only be partially actuated due to the (blocking of the) second actuation part70.

Further actuation of the first actuation part60and/or movement of the plunger rod40from the administration position to the final position is thus prevented/blocked by means of the second actuation part70, at least when the second actuation part70is unactuated and/or in the blocking position. Only after actuating the second actuation part70and/or moving the second actuation part70from the blocking position to the releasing position, the first actuation part60can be actuated again and/or for a second time and/or the plunger rod40can be moved from the administration position to the final position.

As best seen inFIG.5B, the plunger rod40, in particular the actuation intermediate stop46A/47A, abuts the second actuation part70, in particular the blocking wall77, in the administration position. Thus, when reaching the administration position, (further) actuation of the first actuation part60is (temporarily) blocked/prevented by means of the second actuation part70.

Preferably, the second actuation part70is to be actuated, in particular turned/rotated or slided relative to the retainer20and/or around the plunger rod40, preferably by at least essentially 90 degrees, in order to (axially) release the plunger rod40and/or the first actuation part60and/or such that the first actuation part60can be actuated, in particular completely, again, for the second time and/or for administering the fluid11.

As best seen comparingFIGS.5B and5C, the second actuation part70is to be actuated—in particular by sliding or rotating—to align the second actuation part70, in particular the opening78, with and/or relative to the first actuation part60and/or the plunger rod40, in particular the actuation intermediate stop46A/47A, and/or such that the plunger rod40, in particular the actuation intermediate stop46A/47A, can move through the opening78of the second actuation part70.

Preferably, the second actuation part70can (only) be actuated until a predefined position is reached and/or until further actuation, in particular rotation, of the second actuation part70is blocked by the retainer20, in particular the actuation stop27, and/or until the actuation stop76of the second actuation part70hits/abuts the actuation stop27of the retainer20.

As best seen inFIG.7B, the position and/or angle of rotation of the second actuation part70is at least essentially fixed and/or limited after actuating the second actuation part70.

Preferably, further actuation/rotation is blocked/prevented by means of the actuation stop27and back-rotation is blocked/prevented by means of the back-rotation stop26of the retainer20.

After (completely) actuating the second actuation part70, the retainer20, in particular the support22, mostly preferred the back-rotation stop26, (circumferentially) abuts/blocks and/or (radially) engages the second actuation part70, in particular the second back-rotation stop75, in a direction opposite to the direction of actuation/rotation and the retainer20, in particular the support22, mostly preferred the actuation stop27, engages the second actuation part70, in particular the actuation stop76, in the direction of actuation/rotation.

Optionally, the retainer20provides an increased rotational resistance at the beginning and/or at the end of actuating the second actuation part70, thereby providing an audible/haptic feedback to a user/practitioner indicating the beginning and/or the end of actuation of the second actuation part70.

In the present embodiment, the second actuation part70, in particular the second back-rotation stop75, is to be pushed over a (radial) protrusion at the beginning and at the end of the actuation of the second actuation part70. However, other solutions are possible as well.

After actuating the second actuation part70, the first actuation part60is (axially) unblocked/released (in its direction of actuation) and can be actuated, in particular again and/or for the second time and/or for moving the plunger rod40from the administration position to the final position and/or further into the container10.

By actuating, in particular depressing, the first actuation part60, in particular again and/or for a second time and/or after actuating the second actuation part70, the administration of the fluid11can be carried out and/or the plunger rod40and/or the stopper18are/is moved to the final position and/or further into the container10.

FIGS.4D and5Dshow the administration device100in the final position/state, i.e. after completely actuating the first actuation part60.

As best seen comparingFIGS.4C and4D, the first actuation part60can be actuated, in particular depressed, preferably only until the plunger rod40, in particular the actuation stop44D/45D, (axially) abuts/engages the second actuation part70, in particular the blocking wall77. Alternatively or additionally, the first actuation part60may abut/hit the actuation part70, in particular its outer part71.

Thus, in the final position/state, the plunger rod40and/or the first actuation part60(axially) abuts/engages the second actuation part70, in particular its blocking wall77, thereby in particular preventing further actuation of the first actuation part60and/or insertion of the plunger rod40.

In particular, the position of the plunger rod40and/or the stopper18is predefined by means of the second actuation part70, in particular its blocking wall77, in the administration position and in the final position, thereby increasing the dose accuracy.

The final position is preferably the (axial) position of the stopper18and/or plunger rod40relative to the retainer20and/or container10immediately (after) administration and/or after (completely) actuating the first actuation part60and/or in the final state of the administration device100.

In the final state of the administration device100and/or when the plunger rod40and/or the stopper18are/is in the final position, the administration of the fluid11has been carried out, the first actuation part60is completely actuated and/or further actuation of the first actuation part60and/or the second actuation part70is in particular mechanically prevented.

As already mentioned, the administration device100may be adapted for ophthalmic injections. The administration device100preferably comprises suitably small volumes of the fluid11to be injected.

The administration device100, in particular the container10, may be silicon-free, or at least essentially silicon-free or may comprise a low level of silicon as lubricant. Preferably, the administration device100and/or the container10meets the requirements of USP 789.

The administration device100, in particular the container10, may be filled with any suitable injectable fluid/liquid/medication11.

According to a preferred embodiment, the administration device100, in particular the container10, is filled with the fluid11, in particular an injectable medicament, comprising an active suitable for the treatment of an ocular disease. Examples for such ocular diseases include choroidal neovascularization, age-related macular degeneration (AMD, both wet and dry forms), macular edema secondary to retinal vein occlusion (RVO) including both branch RVO (bRVO) and central RVO (cRVO), choroidal neovascularization secondary to pathologic myopia (PM), diabetic macular edema (DME), diabetic macular ischemia (DMI), geographic atrophy, diabetic retinopathy, and proliferative retinopathy.

According to another preferred embodiment, the fluid11, in particular the injectable medicament, comprises a biologic active ingredient, such as an antibody (or a fragment thereof) or a non-antibody protein.

In one embodiment, the fluid11, in particular the injectable medicament, comprises a VEGF antagonist, a multi-specific anti-VEGF/Ang2 antibody or a fragment thereof, a multi-specific anti-VEGF/AngPT2 antibody or a fragment thereof, a multi-specific anti-VEGF/TrkB agonist, or a multi-specific anti-VEGF/APL-2 complement C3 inhibitor, such as ranibizumab, bevacizumab, aflibercept, brolucizumab, conbercept (KH902) and the related glycoform KH906, faricinab or pazopanib.

Individual aspects and features of the present invention may be implemented independently from one another, but also in any combination and/or order.

In particular, the present invention relates also to any of the following aspects which can be realized independently or in any combination, also in combination with any aspect described above:1. Administration device (100) for in particular intravitreal administration of a fluid (11), the administration device (100) comprising:a retainer (20) for a container (10) containing the fluid (11), andan actuation mechanism comprising a plunger rod (40), a first actuation part (60) and a second actuation part (70), the second actuation part (70) being movably attached to the retainer (20), wherein the plunger rod (40) is adapted to act on a stopper (18) movably arranged within the container (10), andwherein the first actuation part (60) can be manually actuated in order to axially move the plunger rod (40) relative to the retainer (20), characterized,in that the second actuation part (70) is configured to axially block the plunger rod (40) and/or the first actuation part (60), wherein the second actuation part (70) is to be actuated in order to axially release the plunger rod (40) and/or the first actuation part (60) such that the first actuation part (60) can be actuated, and/orin that the actuation mechanism comprises a securing member (90), wherein the securing member (90) is configured to block a back-movement of the plunger rod (40) and/or the first actuation part (60) at least in an initial position and/or in an administration position of the plunger rod (40) and wherein the securing member (90) is configured to block the second actuation part (70) in the initial position and/or before reaching the administration position.2. Administration device, preferably according to aspect 1, characterized in that the plunger rod (40) axially extends through the retainer (20) and/or the second actuation part (70).3. Administration device, preferably according to aspect 1 or 2, characterized in that the first actuation part (60) can be actuated by—in particular manually—pushing the first actuation part (60) towards the second actuation part (70) and/or towards the retainer (20).4. Administration device, preferably according to any of the preceding aspects, characterized in that the second actuation part (70) can be actuated by—in particular manually—rotating or sliding the second actuation part (70) relative to the retainer (20) and/or around the plunger rod (40), preferably by at least essentially 90 degrees and/or in order to change the alignment of the second actuation part (70) relative to the first actuation part (60) and/or the plunger rod (40).5. Administration device, preferably according to any of the preceding aspects, characterized in that the plunger rod (40) comprises a cross section that varies along the main axis (A) of the plunger rod (40) and/or in that the second actuation part (70) comprises an opening (78), wherein the second actuation part (70) is to be actuated to—in particular rotationally or slidingly—align the opening (78) with the plunger rod (40) such that the plunger rod (40) can move through the opening (78).6. Administration device, preferably according to any of the preceding aspects, characterized in that the first actuation part (60) can be—in particular manually—actuated in order to move the plunger rod (40) from an initial position to an administration position and/or—in particular subsequently and/or after actuating the second actuation part (70)— from the administration position to a final position.7. Administration device, preferably according to any of the preceding aspects, characterized in that the second actuation part (70) is configured to axially block the plunger rod (40) and/or the first actuation part (60) in the initial position of the plunger rod (40), wherein the second actuation part (70) is to be actuated, in particular rotated or slided relative to the retainer (20) and/or around the plunger rod (40), preferably by at least essentially 90 degrees, in order to unblock the plunger rod (40) and/or the first actuation part (60) and/or such that the first actuation part (60) can be actuated, in particular for the first time and/or for priming of the administration device (100), and/or such that the plunger rod (40) can be moved from the initial position to the administration position.8. Administration device, preferably according to any of the preceding aspects, characterized in that the second actuation part (70) is configured to axially block the plunger rod (40) and/or the first actuation part (60) in the administration position of the plunger rod (40), wherein the second actuation part (70) is to be actuated, in particular rotated or slided relative to the retainer (20) and/or around the plunger rod (40), preferably by at least essentially 90 degrees, in order to unblock the plunger rod (40) and/or the first actuation part (60) and/or such that the first actuation part (60) can be actuated, in particular for the second time and/or for administrating of the fluid (11), and/or such that the plunger rod (40) can be moved from the administration position to the final position.9. Administration device, preferably according to any of the preceding aspects, characterized in that the actuation mechanism comprises a securing member (90) for securing the plunger rod (40), the first actuation part (60) and/or the second actuation part (70), preferably wherein the retainer (20) comprises a receptacle (22A) for the securing member (90).10. Administration device, preferably according to aspect 9, characterized in that the securing member (90) is ring-shaped and/or in that the plunger rod (40) axially extends through the securing member (90).11. Administration device, preferably according to aspect 9 or 10, characterized in that the securing member (90) is embodied as a preferably flexible ring and/or in that the securing member (90) is coupled loosely and/or with radial play to the plunger rod (40) in the initial position and/or in the administration position and/or in that the securing member (90) is radially pretensioned against and/or tightly coupled to the plunger rod (40) during movement of the plunger rod (40) from the initial position towards the administration position.12. Administration device, preferably according to any of the aspects 9 to 11, characterized in that the securing member (90) engages the plunger rod (40) and/or in that the securing member (90) is configured to block a back-movement of the plunger rod (40) and/or the first actuation part (60), at least in the initial position and/or in the administration position of the plunger rod (40).13. Administration device, preferably according to any of the aspects9to12, characterized in that the securing member (90) engages the second actuation part (70) and/or in that the securing member (90) is configured to block actuating the second actuation part (70), in particular in the initial position and/or before and/or only until the plunger rod (40) reaches the administration position, and/or to automatically unblock actuation of the second actuation part (70) upon actuating the first actuation part (60) and/or when the administration position is reached.14. Administration device, preferably according to any of the aspects9to13, characterized in that the plunger rod (40) comprises or forms a ramp (44C) for the securing member (90) and/or in that the plunger rod (40), in particular its ramp (44C), is configured to—in particular further—tension and/or widen the securing member (90) upon actuating the first actuation part (60) and/or during movement of the plunger rod (40) from the initial position towards the administration position.15. Administration device, preferably according to any of the aspects9to14, characterized in that the plunger rod (40) comprises an indentation (45C) for the securing member (90) and/or in that the plunger rod (40), in particular its indentation (45C), is configured to at least partially, preferably completely, and/or audibly release the securing member (90) and/or to disengage the securing member (90) from the second actuation part (70) upon actuating the first actuation part (60) and/or when reaching the administration position, in particular such that the second actuation part (70) can be actuated, in particular for the first time, and/or in such a way that an audible and/or haptic feedback is provided.