Compounds of formula (I): 1 or pharmaceutically, veterinarily or agriculturally acceptable salts thereof, or pharmaceutically, veterinarily or agriculturally acceptable solvates of either entity, wherein R 1 is 2,4,6-trisubstituted phenyl or 3,5-disubstituted pyridin-2-yl; R 3 is hydrogen; C 2 to C 5 alkyl substituted with one or more halo and with hydroxy; C 2 to C 5 alkanoyl substituted with one or more halo; C 2 to C 6 alkenyl optionally substituted with one or more halo; halo; amino or CONH 2 ; R 5 is hydrogen, amino or halo; R 2 and R 4 are each independently selected from hydrogen, fluoro, chloro and bromo; R 6 and R 8 are hydrogen; and R 7 is hydrogen or C 1 to C 4 alkyl optionally substituted with one or more halo; are parasiticidal agents.

EXAMPLE 1 
 4-(2,2-Dibromocyclopropyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-(propen-2-yl)pyrazole A 2.5M solution of n-butyllithium in hexane (0.43 ml) was added dropwise to a stirred, ice-cooled suspension of methyltriphenylphosphonium bromide (0.377 g) in anhydrous ether (5 ml) and the mixture heated under reflux for 1 hour, then ice-cooled. A solution of the title compound of Preparation 62 (0.50 g) in ether (5 ml) was added dropwise, maintaining the reaction temperature below 5° C., and the reaction mixture heated under reflux for 30 minutes, then allowed to cool. The resulting mixture was washed successively with aqueous sodium sulphate solution and water, then the combined washings extracted with ether. The combined organic solutions were washed with brine, dried (Na 2 SO 4 ) and evaporated under reduced pressure, then the residue purified by column chromatography on silica gel, using a mixture of hexane:ether (20:1) as eluant, followed by trituration with cold hexane, to furnish the title compound as a white solid, m.p. 86.5-88.2° C. &dgr;(CDCl 3 ): 1.85 (t,1H), 2.20 (dd,1H), 2.25 (s,3H), 2.80 (dd,1H), 5.45 (s,1H), 5.75 (s,1H), 7.25 (s,1H), 7.70 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 517.1; C 16 H 11 Br 2 Cl 2 F 3 N 2 &plus;H requires 516.87. 
 EXAMPLE 2 
 4-(2,2-Dibromocyclopropyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-(1-hvdroxy-2,2,2-trifluoroethyl)pyrazole A 1M solution of tetra-n-butylammonium fluoride in tetrahydrofuran (0.1 ml) was added to a stirred, icecooled solution of the title compound of Preparation 63 (0.65 g) and (trifluoromethyl)trimethylsilane (0.37 g) in tetrahydrofuran (10 ml). The reaction mixture was allowed to warm to room temperature, stirred for a further 24 hours and then evaporated under reduced pressure. The residue was dissolved in methanol (10 ml), then the solution treated with 2M hydrochloric acid (0.2 ml), stirred for 1 hour and evaporated under reduced pressure. Purification of this residue by column chromatography on silica gel, using a mixture of hexane:ethyl acetate (9:1) as eluant, provided the title compound as a white solid, m.p. 119-121° C. &dgr;(CDCl 3 ): 1.81 (t,1H), 2.23 (dd,1H), 2.80 (dd,1H), 3.31 (d,1H), 5.30 (dq,1H), 7.38 (s,1H), 7.74 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 574.5; C 15 H 8 Br 2 Cl 2 F 6 N 2 O&plus;H requires 573.83. 
 EXAMPLE 3 
 4-(2,2-Dibromocyclopropyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-trifluoroacetylpyrazole Tetra-n-propylammonium perruthenate (50 mg) was added to a stirred solution of the title compound of Example 2 (0.15 g) and 4-methylmorpholine N-oxide (50 mg) in acetonitrile (5 ml) containing powdered 4 &angst; molecular sieves. The reaction mixture was stirred at room temperature for 24 hours and then evaporated under reduced pressure. Purification of the residue by column chromatography on silica gel, using dichloromethane as eluant, followed by chromatographic reprocessing, using hexane and then a mixture of hexane: ethyl acetate (19:1) as eluants, gave the title compound as a colourless oil. &dgr; (CDCl 3 ): 1.83 (t,1H), 2.20 (dd,1H), 3.24 (dd,1H), 7.44 (s,1H), 7.79 (s,2H). IR (thin film): &ngr; max 1722.9 cm −1 . 
 EXAMPLE 4 
 4-(2,2-Dibromocyclopropyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-ethenylpyrazole A 2.5M solution of n-butyllithium in hexane (0.20 ml) was added dropwise to a stirred, ice-cooled suspension of methyltriphenylphosphonium bromide (0.10 g) in anhydrous tetrahydrofuran (10 ml). After 30 minutes, a solution of the title compound of Preparation 63 (0.10 g) in tetrahydrofuran (5 ml) was added and the reaction mixture stirred for a further 24 hours. Next water (10 ml), methanol (10 ml) and ether (30 ml) were added, then the organic phase separated, washed with brine, dried (MgSO 4 ) and evaporated under reduced pressure. The resulting yellow oil was purified by repeated column chromatography on silica gel, using mixtures of hexane:ethyl acetate (19:1, then 49:1, then 99:1) as eluants, followed by reverse phase HPLC on C18 silica, using a mixture of acetonitrile:water:methanol (60:30:10) as eluant, to afford the title compound as an oil. &dgr;(CDCl 3 ): 1.84 (t, 1H), 2.22 (dd, 1H), 2.79 (dd,1H), 5.60 (d, 1H), 6.11 (d,1H), 6.90 (dd,1H), 7.28 (s, 1H), 7.72 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 503.1; C 15 H 9 Br 2 Cl 2 F 3 N 2 &plus;H requires 502.85. 
 EXAMPLE 5 
 4-(2,2-Dibromocyclopropyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-(2,2-difluoroethenyl)pyrazole Dibromodifluoromethane (0.055 ml) was added to a stirred, ice-cooled solution of the title compound of Preparation 63 (0.15 g) in anhydrous tetrahydrofuran (5 ml), followed by the dropwise addition of a solution of hexamethylphosphorous triamide (0.14 ml) in anhydrous tetrahydrofuran (3 ml). The reaction mixture was allowed to warm to room temperature, stirred for a further 24 hours, then evaporated under reduced pressure. The resulting residue was purified by column chromatography on silica gel, using a mixture of hexane:ethyl acetate (19:1) as eluant, to give the title compound as a white solid, m.p. 71-73° C. &dgr;(CDCl 3 ): 1.80 (t,1H), 2.20 (dd,1H), 2.66 (dd,1H), 5.47 (d,1H), 7.30 (s,1H), 7.70 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 538.7; C 15 H 7 Br 2 Cl 2 F 5 N 2 &plus;H requires 538.83. 
 EXAMPLE 6 
 4-(2,2-Dibromocyclopropyl)-3-(2,2-dibromoethenyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole A solution of the title compound of Preparation 63 (0.15 g) in dichloromethane (2 ml) was added to a stirred solution of carbon tetrabromide (0.20 g) and triphenylphosphine (0.315 g) in dichloromethane (8 ml). The resulting mixture was stirred at room temprature and then applied to a column of silica gel (10 g). Elution with dichloromethane, followed by trituration of the required productwith hexane, yielded the title compound as a white solid, m.p. 106-107° C. &dgr;(CDCl 3 ): 1.80 (t,1H), 2.25 (dd,1H), 2.80 (dd,1H), 7.34 (s,1H), 7.56 (s,1H), 7.82 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 658.4; C 15 H 7 Br 4 Cl 2 F 3 N 2 &plus;H requires 658.68. 
 EXAMPLE 7 
 3-Carbamoyl-4-(2,2-dibromocyclopropyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole Urea:hydrogen peroxide addition compound (percarbamide; 1.494 g) and potassium carbonate (0.055 g) were added to a stirred solution of the title compound of Preparation 43 (2.0 g) in a mixture of acetone (10 ml) and water (5 ml). After a further 24 hours, the precipitate was collected and dried to provide the title compound as a white solid, m.p. 186.2-187.3° C. &dgr;(CDCl 3 ): 1.80 (t,1H), 2.25 (dd,1H), 3.50 (dd,1H), 5.53 (br.s, 1 H), 6.77 (br.s,1H), 7.34 (s,1H), 7.76 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 520.2; C 14 H 8 Br 2 Cl 2 F 3 N 3 O&plus;H requires 519.84. 
 EXAMPLE 8 
 3-Amino-4-(2,2-dibromocyclopropyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole 0.5M Aqueous sodium hypochlorite solution (40 ml) was added dropwise to a stirred solution of the title compound of Example 7 (4.098 g) in methanol (100 ml) and the mixture heated under reflux for 6 hours, allowed to cool and then neutralised with dilute hydrochloric acid. The resulting mixture was extracted (×3) with ether and the combined extracts washed with brine, dried (Na 2 SO 4 ) and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel, using mixtures of hexane:ethyl acetate (9:1 then 4:1) as eluants, followed by crystallisation of the required product from hexane-toluene, to give the title compound as a white solid, m.p. 124.9-126° C. &dgr;(CDCl 3 ): 1.70 (br.s,1H), 1.80 (t,1H), 2.15 (dd,1H), 2.50 (dd,1H), 3.90 (br.s,1H), 7.10 (s,1H), 7.70 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 491.9; C 13 H 8 Br 2 Cl 2 F 3 N 2 &plus;H requires 491.85. 
 EXAMPLE 9 
 4-(2,2-Dibromocyclopropyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole t-Butyl nitrite (0.12 ml) was added dropwise to a stirred, ice-cooled solution of the title compound of Example 8 (0.25 g) in tetrahydrofuran (5 ml). The reaction mixture was then allowed to warm to room temperature, stirred for 1 hour, heated under reflux for 30 minutes, allowed to cool and partitioned between ether and water. The aqueous phase was separated and extracted with ether, then the combined ether solutions washed with brine, dried (Na 2 SO 4 ) and evaporated under reduced pressure. Purification of the residue by column chromatography on silica gel, using a mixture of hexane:ethyl acetate (9:1) as eluant, furnished the title compound as a colourless oil. &dgr; (CDCl 3 ): 1.85 (t,1H), 2.20 (dd,1H), 2.80 (dd,1H), 7.45 (s,1H), 7.75 (s,2H), 7.78 (s,1H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 476.7; C 13 H 7 Br 2 Cl 2 F 3 N 2 &plus;H requires 476.84. 
 EXAMPLE 10 
 3-Chloro-4-(2,2-dibromocyclopropyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole t-Butyl nitrite (0.07 ml) was added dropwise to a stirred solution of trimethylsilyl chloride (0.08 ml) in anhydrous dichloromethane (2.5 ml) at about −5° C. After a further 5 minutes, a solution of the title compound of Example 8 (0.10 g) in anhydrous dichloromethane (4.5 ml) was added dropwise, whilst maintaining the reaction temperature below −5° C. Next, the reaction mixture was allowed to warm to room temperature, stirred for 45 minutes more and then evaporated under reduced pressure. The residue was purified by column chromatography on silica gel, using mixtures of hexane:dichloromethane (9:1 then 4:1) as eluants, to afford the title compound as a colourless gum. &dgr; (CDCl 3 ): 1.85 (t,1H), 2.25 (dd,1H), 2.70 (dd,1H), 7.35 (s,1H), 7.75 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 510.7; C 13 H 6 Br 2 Cl 3 F 3 N 2 &plus;H requires 510.80. 
 EXAMPLE 11 
 3-Bromo4-(2,2-dibromocyclopropyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole Bromoform (2 ml) was added to a stirred solution of the title compound of Example 8 (0.25 g) in acetonitrile (2 ml) and the mixture cooled to about 0° C. t-Butyl nitrite was added dropwise, then the reaction mixture allowed to warm to room temperature, stirred for 1 hour at room temperature and then for 1 hour under reflux, allowed to cool and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel, using mixtures of hexane:ether (19:1 then 9:1) as eluants, to provide the title compound as a colourless gum. &dgr;(CDCl 3 ): 1.85 (t,1H), 2.25 (dd,1H), 2.70 (dd,1H), 7.25 (s,1H), 7.70 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 554.5; C 13 H 6 Br 3 Cl 2 F 3 N 2 &plus;H requires 554.75. 
 EXAMPLE 12 
 4-(2,2-Dibromocyclopropyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-iodopyrazole Iodine (0.55 g) was added to a stirred solution of the title compound of Example 8 (0.40 g) in dichloromethane (10 ml), followed by the dropwise addition of t-butyl nitrite (0.21 g). The reaction mixture was stirred at room temperature for 2 hours, then partitioned between dichloromethane and aqueous sodium thiosulphate solution and the organic phase separated, dried and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel, using hexane and then dichloromethane as eluants, followed by reverse phase HPLC on C18 silica, using a mixture of acetonitrile:water:methanol (30:60:10) as eluant, to produce the title compound as an off-white foam. &dgr;(CDCl 3 ): 1.84 (t,1H), 2.26 (dd,1H), 2.67 (dd,1H), 7.20 (s,1H), 7.72 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 602.4; C 13 H 6 Br 2 Cl 2 F 3 IN 2 &plus;H requires 602.74. 
 PREPARATION 1 
 5-Amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-iodopyrazole N-Iodosuccinimide (3.52 g) was added in portions, over 5 minutes, to a stirred solution of 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole (EP-A-0295117; 5.0 g) in acetonitrile (60 ml) at room temperature. After being stirred for 1 hour, the reaction mixture was evaporated under reduced pressure to provide the required crude product (8.2 g) which, despite containing succinimide, may be used without further purification. If desired, purification may be effected by partitioning the crude product between dichloromethane and water, separating and drying (MgSO 4 ) the organic phase and evaporating it under reduced pressure, then triturating the resulting yellow solid with hexane to give the title compound as a white solid, m.p. 213° C. (decomp.). 
 PREPARATION 2 
 5-Amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-ethenylpyrazole Tri-n-butyl(vinyl)tin (4.25 g) and tetrakis(triphenylphosphine)palladium(O) (0.3 g) were added to a stirred solution of the title compound of Preparation 1 (2.0 g) in dimethylformamide (10 ml) at room temperature and the resulting mixture heated at 75° C. for 1 hour, then stirred at room temperature for a further 60 hours, before being diluted with water. The mixture was extracted with ether and the combined extracts washed with brine, dried (MgSO 4 ) and evaporated under reduced pressure to furnish the crude product (6.0 g) as a black oil, which was purified by column chromatography on silica gel (200 g), using hexane: dichloromethane (1:1) as eluant, to afford the title compound as a buff solid, m.p. 186-187° C. &dgr;(CDCl 3 ): 3.85 (s,2H), 5.41 (d,1H), 5.70 (d,1H), 6.52 (dd,1H), 7.80 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 347.0; C 13 H 7 Cl 2 F 3 N 4 &plus;H requires 347.0. 
 PREPARATION 3 
 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-iodopyrazole t-Butyl nitrite (144 ml) was added over 30 minutes to a stirred solution of the title compound of Preparation 1 (90 g) in tetrahydrofuran (720 ml) at 65° C. After 3 hours at 65° C., the reaction mixture was allowed to cool and evaporated under reduced pressure, then the residue crystallised from propanol to give the title compound as a white solid, m.p. 83-84° C. &dgr;(CDCl 3 ): 7.70 (s,1H), 7.79 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 448.8; C 11 H 3 Cl 2 F 3 IN 3 &plus;NH 4 requires 448.9. 
 PREPARATION 4 
 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-ethenylpyrazole A solution of the title compound of Preparation 3 (58 g), tri-n-butyl(vinyl)tin (116 ml) and tetrakis(triphenylphosphine)palladium(O) (3.5 g) in dimethylformamide (350 ml) was stirred at 75° C. for 3 hours and then allowed to cool. The reaction mixture was partitioned between ether (600 ml) and water (600 ml), then the organic phase washed successively with water (×5) and brine, dried (Na 2 SO 4 ) and evaporated under reduced pressure. Crystallisation of the residue from propan-2-ol provided the title compound as a pale brown solid, m.p. 75-76° C. &dgr;(CDCl 3 ): 5.50 (d,1H), 5.94 (d,1H), 6.64 (dd,1H), 7.64 (s,1H), 7.77 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 349.5; C 13 H 6 Cl 2 F 3 N 3 &plus;NH 4 requires 349.02. 
 PREPARATION 5 
 5-Amino-3-cyano-1-(2,6-dichloro-4-pentafluorothiophenyl)-4-iodopyrazole N-Iodosuccinimide (11.5 g) was added in four portions, over 5 minutes, to a stirred solution of 5-amino-3-cyano-1-(2,6-dichloro-4-pentafluorothiophenyl)pyrazole (WO-A-93/06089; 18.95 g) in acetonitrile (100 ml) at room temperature. After a further 15 minutes, the reaction mixture was evaporated under reduced pressure and the residual solid treated with a mixture of dichloromethane and water. The insoluble material was collected by filtration and dissolved in ethyl acetate, then this solution was dried (Na 2 SO 4 ) and evaporated under reduced pressure to furnish the title compound as a buff solid, m.p. 253° C. &dgr;(CDCl 3 ): 3.94 (br.s,2H), 7.92 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 521.9; C 10 H 4 Cl 2 F 5 IN 4 S&plus;NH 4 requires 521.88. 
 PREPARATION 6 
 5-Amino-3-cyano-1-(2,6-dichloro-4-Pentafluorothiophenyl)-4-ethenylpyrazole Tri-n-butyl(vinyl)tin (4.5 ml) was added to a stirred, degassed solution of the title compound of Preparation 5 (5.05 g) and tetrakis(triphenylphosphine) palladium(O) (0.175 g) in dimethylformamide (32 ml) at room temperature and the resulting mixture heated to 70° C. over 30 minutes. After a further 1 hour at 70° C. , tri-n-butyl(vinyl)tin (4.5 ml) and tetrakis(triphenylphosphine)palladium(O) (0.175 g) were added and the reaction mixture was heated at 70° C. for 1 hour, then evaporated under reduced pressure. The residue was partitioned between ether and water, then the separated organic phase combined with ether extracts of the aqueous phase, washed with brine, dried (MgSO 4 ) and evaporated under reduced pressure to give a brown paste which was triturated with hexane. The resulting brown solid was treated with ethyl acetate, the mixture filtered, the filtrate evaporated under reduced pressure and the residue crystallised from toluene to yield the title compound as a buff solid, m.p. 227-228° C. &dgr;(CDCl 3 ): 3.86 (s,2H), 5.41 (d,1H), 5.68 (d,1H), 6.50 (dd,1H), 7.92 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 405. 1; C 12 H 7 Cl 2 F 5 N 4 S&plus;H requires 404.98. 
 PREPARATION 7 
 3-Cyano-1-(2,6-dichloro-4-pentafluorothiophenyl)-4-iodopyrazole A solution of t-butyl nitrite (3.1 g) in tetrahydrofuran (15 ml) was added dropwise over 30 minutes to a stirred solution of the title compound of Preparation 5 (2.5 g) in tetrahydrofuran (35 ml), then the reaction mixture was evaporated under reduced pressure. Crystallisation of the residue from propan-2-ol afforded the title compound as a pinkish solid, m.p. 179-180° C. &dgr;(CDCl 3 ): 7.66 (s,1H), 7.90 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 506.4; C 10 H 3 Cl 2 F 5 IN 3 S&plus;NH 4 requires 506.87. 
 PREPARATION 8 
 3-Cyano-1-(2,6-dichloro-4-pentafluorothiophenyl)-4-ethenylpyrazole Tri-n-butyl(vinyl)tin (4.2 ml) was added to a stirred, degassed solution of the title compound of Preparation 7 (1.23 g) and tetrakis(triphenylphosphine) palladium(O) (0.09 g) in dimethylformamide (32 ml) at room temperature and the resulting mixture heated at 70° C. for 1.5 hours, before being evaporated under reduced pressure. The residue was triturated with hexane and the resulting solid purified by dissolution in dichloromethane and column chromatography of the solution on silica gel (60 g), using hexane and then hexane:dichloromethane (80:20) as eluants, to yield the title compound as a white solid, m.p. 156° C. &dgr;(CDCl 3 ): 5.50 (d,1H), 5.95 (d,1H), 6.63 (dd,1H), 7.77 (s,1H), 7.92 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 406.8; C 12 H 6 Cl 2 F 5 N 3 S&plus;NH 4 requires 406.99. 
 PREPARATION 9 
 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-formylpyrazole A solution of the title compound of Preparation 4 (0.1 g), a 2.5 wt. % solution of osmium tetroxide in t-butanol (50 &mgr;l) and 4-methylmorpholine-N-oxide (0.005 g) in 90% aqueous acetone (50 ml) was stirred at room temperature for 16 hours. Sodium metaperiodate (0.005 g) was added and the reaction mixture stirred for a further 16 hours, then evaporated under reduced pressure. The residue was partitioned between ether and saturated aqueous sodium bicarbonate solution, the aqueous phase separated and extracted with ether, then the combined ether extracts dried (Na 2 SO 4 ) and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel (5 g), using dichloromethane as eluant, to give the title compound as a beige solid, m.p. 167.5-168.5° C. &dgr;(CDCl 3 ): 7.80 (s,2H), 8.18 (s,1H), 10.08 (s,1H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 351.3; C 12 H 4 Cl 2 F 3 N 3 O&plus;NH 4 requires 351.0. 
 PREPARATION 10 
 5-Amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trimethylsilylethynylpyrazole Trimethylsilylacetylene (3 ml), cuprous iodide (150 mg) and bis(triphenylphosphine)palladium(II) chloride (300 mg) were added to a stirred solution of the title compound of Preparation 1 (6.96 g) in a mixture of triethylamine (30 ml) and dimethylformamide (6 ml) at room temperature and the resulting mixture heated at 50-60° C. for 1 hour. More trimethylsilylacetylene (0.3 ml) was added, then the reaction mixture stirred for 30 minutes at 50-60° C., allowed to cool and diluted with water (250 ml). This mixture was extracted with ether (250 ml), using brine to facilitate phase separation, and the aqueous phase separated and extracted with ether (250 ml). The combined ether extracts were dried (MgSO 4 ) and evaporated under reduced pressure to furnish a gum (4.67 g) which was purified by column chromatography on silica gel, using hexane:dichloromethane (1:1) as eluant, followed by crystallisation of the required material from hexane-ether, thus affording the title compound as a white solid, m.p. 181-182° C. &dgr;(CDCl 3 ): 0.20 (s,9H), 4.10 (br.s,2H), 7.70 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 434.2; C 16 H 13 Cl 2 F 3 N 4 Si&plus;NH 4 requires 434.0. 
 PREPARATION 11 
 5-Amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-ethynylpyrazole Potassium carbonate (1.0 g) was added to a stirred solution of the title compound of Preparation 10 (2.0 g) in methanol (30 ml). After 10 minutes at room temperature, the reaction mixture was partitioned between ether (100 ml) and water (100 ml), then the organic phase separated, washed with brine (100 ml), dried (MgSO 4 ) and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel, using dichloromethane as eluant, followed by crystallisation from ether, to give the title compound as a white solid, m.p. 215-216° C. &dgr;(CDCl 3 ): 3.49 (s,1H), 4.20 (br.s,2H), 7.80 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 362.4; C 13 H 5 Cl 2 F 3 N 4 &plus;NH 4 requires 362.0. 
 PREPARATION 12 
 4-Acetyl-5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole p-Toluenesulphonic acid (0.5 g) was added to a stirred solution of the title compound of Preparation 11 (0.345 g) in acetonitrile (5 ml). After a further 2 hours at room temperature, the reaction mixture was partitioned between ether (100 ml) and water (100 ml), then the organic phase separated, washed successively with saturated aqueous sodium bicarbonate solution and brine, dried (Na 2 SO 4 ) and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel (40 g), using hexane:dichloromethane (1:10) as eluant, to provide the title compound as a white crystalline solid, m.p. 200-201° C. &dgr;(CDCl 3 ): 2.65 (s,3H), 5.83 (br.s,2H), 7.82 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 380.4; C 13 H 7 Cl 2 F 3 N 4 O&plus;NH 4 requires 380.03. 
 PREPARATION 13 
 4-Acetyl-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole t-Butyl nitrite (0.0262 ml) was added dropwise to a stirred solution of the title compound of Preparation 12 (0.4 g) in tetrahydrofuran (2 ml). The reaction mixture was heated under reflux for 30 minutes and then applied to a silica gel (1.0 g) column. Elution with tetrahydrofuran yielded the title compound as a white solid, m.p. 166-168° C. &dgr;(CDCl 3 ): 2.67 (s,3H), 7.80 (s,2H), 8.12 (s,1H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 365.0; C 13 H 6 Cl 2 F 3 N 3 O&plus;NH 4 requires 365.02. 
 PREPARATION 14 
 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(1-methylethenyl)pyrazole A 2.5M solution of n-butyllithium in tetrahydrofuran (0.64 ml) was added to a stirred suspension of methyltriphenylphosphonium bromide (0.565 g) in anhydrous ether (10 ml) to provide a yellow solution, to which was added a solution of the title compound of Preparation 13 (0.5 g) in anhydrous tetrahydrofuran (10 ml). The reaction mixture was heated at 30° C. for 4 hours, allowed to cool and partitioned between ether (100 ml) and saturated aqueous sodium bicarbonate solution (100 ml). The organic phase was separated, dried and evaporated under reduced pressure, then the residue purified by column chromatography on silica gel, using hexane:dichloromethane (1:9) as eluant, to furnish the title compound as a white solid, m.p. 129-130° C. &dgr;(CDCl 3 ): 2.16 (s,3H), 5.29 (s,1H), 5.80 (s,1H), 7.59 (s,1H), 7.88 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 362.9; C 14 H 8 Cl 2 F 3 N 3 &plus;NH 4 requires 363.04. 
 PREPARATION 15 
 N-&lsqb;3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole-4-ylmethylidene&rsqb;-N′-(4-methylphenylsulphonyl)hydrazine, lithium salt A solution of the title compound of Preparation 9 (0.333 g) and p-toluenesulphonylhydrazine (0.186 g) in tetrahydrofuran was stirred at room temperature for 10 minutes and then activated 3 &angst; molecular sieves (2 pellets, ca. 0.011 g) were added. The mixture was cooled to −78° C. under nitrogen and a 2.5M solution of n-butyllithium in hexane (0.4 ml) added over 3 minutes. The reaction mixture was allowed to warm to room temperature, filtered and the filtrate treated with hexane (40 ml). The resulting white precipitate was collected by filtration and dried to provide the title compound as a white solid. &dgr;(DMSO d 6 ): 2.28 (s,3H), 7.10 (d,2H), 7.45 (s,1H), 7.68 (d,2H), 8.23 (s,1H), 8.28 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 507.8; C 19 H 11 Cl 2 F 3 N 5 O 2 SLi&plus;H requires 508.02. 
 PREPARATION 16 
 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoroacetylpyrazole t-Butyl nitrite (12.45 ml) was added dropwise to a stirred solution of 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoroacetylpyrazole (JP-A-8-311036; 30 g) in tetrahydrofuran (250 ml) and the mixture stirred at 55° C. for 16 hours. Further quantities of t-butyl nitrite added/subsequent periods of stirring at 55° C. were as follows: 9 ml/7 hours, 6 ml/16 hours, 9 ml/6 hours, 4.75 ml/16 hours, 6 ml/6 hours and 3.5 ml/22 hours. The reaction mixture was allowed to cool and evaporated under reduced pressure, then the residue combined with those obtained from three identical preparations. Purification by column chromatography on silica gel (1 Kg), using hexane:dichloromethane (6:4) and then dichloromethane as eluants, gave a yellow oil which, on trituration with hexane (3×50 ml) followed by dichloromethane (100 ml), provided the title compound as a white solid, m.p. 124-125° C. &dgr;(CDCl 3 ): 7.83 (s,2H), 8.30 (s, 1 H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 401.7; C 13 H 3 Cl 2 F 6 N 3 O&plus;H requires 401.96. 
 PREPARATION 17 
 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(3,3,3-trifluoropropen-2-yl)pyrazole A 2.5M solution of n-butyllithium in hexane (0.11 ml) was added dropwise to a stirred suspension of methyltriphenylphosphonium iodide (111 mg) in tetrahydrofuran (6 ml) under nitrogen at room temperature. The resulting reddish brown solution was added dropwise, under nitrogen, to a stirred solution of the title compound of Preparation 16 (10 mg) in tetrahydrofuran (1 ml) at room temperature and the reaction mixture stirred for 30 minutes. Water (30 ml) was then added, extraction with ether (50 ml) effected and the organic extract dried (Na 2 SO 4 ) and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel (10 g), using hexane:dichloromethane (1:1) as eluant, to yield the title compound as a white solid, m.p. 103-104° C. &dgr;(CDCl 3 ): 6.20 (s,1H), 6.39 (s,1H), 7.78 (s,1H), 7.80 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 399.8; C 14 H 5 Cl 2 F 6 N 3 &plus;H requires 400.0. 
 PREPARATION 18 
 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(3-trifluoromethyl-1-pyrazolin-3-yl)pyrazole A solution of diazomethane (40 mmol) in ether (100 ml) was added slowly to a stirred solution of the title compound of Preparation 17 (27 g) in ether (150 ml) at room temperature and the mixture stirred for 40 minutes. More diazomethane (50 mmol) in ether (150 ml) was slowly added and the reaction mixture stirred for a further 16 hours at room temperature. The excess diazomethane was distilled off, then the solvent evaporated under reduced pressure to provide the title compound as a white solid. &dgr;(CDCl 3 ): 2.23 (m,1H), 2.52 (m,1H), 4.90 (m,2H), 7.78 (s,2H), 8.15 (s,1H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 458.8; C 15 H 7 Cl 2 F 6 N 5 &plus;NH 4 requires 459.0. 
 PREPARATION 19 
 5-Chloro-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-iodopyrazole A ca. 1 M solution of nitrosyl chloride in dichloromethane (2.7 ml) was added dropwise to a stirred, ice-cooled solution of the title compound of Preparation 1 (1.0 g) in acetonitrile (15 ml), then the reaction mixture heated under reflux for 10 minutes and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel, using hexane:toluene (2:1) and then toluene as eluants, to give the title compound as a pale orange solid, m.p. 115.7-116.3° C. &dgr;(CDCl 3 ): 7.80 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 466.0; C 11 H 2 Cl 3 F 3 IN 3 &plus;H requires 465.84. 
 PREPARATION 20 
 5-Chloro-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-ethenylpyrazole Tetrakis(triphenylphosphine)palladium (O) (0.448 g) was added to a stirred solution of the title compound of Preparation 21 (6.0 g) in dimethylformamide (75 ml) at room temperature followed, 5 minutes later, by the dropwise addition of tri-n-butyl(vinyl)tin (11.3 ml). The resulting mixture was heated at 70° C. for 18 hours, then evaporated under reduced pressure and the residue partitioned between ether and water. The organic phase was separated, dried and evaporated under reduced pressure, then the resulting residue purified by column chromatography on silica gel, using hexane and then hexane:dichloromethane (2:1) as eluants, followed by crystallisation from hexane, to yield the title compound as a white solid, m.p. 69.8-70.4° C. &dgr; (CDCl 3 ): 5.61 (d,1H), 6.20 (d,1H), 6.56 (dd,1H), 7.80 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 383.1; C 13 H 5 Cl 3 F 3 N 3 &plus;NH 4 requires 382.98. 
 PREPARATION 21 
 5-Amino-4-chlorodifluoroacetyl-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole Chlorodifluoroacetic anhydride (30.37 g) was added dropwise to a stirred, ice-cooled solution of 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole (EP-A-0295117; 20.0 g) in pyridine (200 ml), then the reaction mixture stirred at room temperature for 16 hours. The resulting mixture was concentrated by removal of pyridine (150 ml) under reduced pressure, then poured into stirred ice/water (500 ml). The pH of this mixture was adjusted to 1 by the dropwise addition of concentrated hydrochloric acid (30 ml), with stirring, and extraction with ethyl acetate (2×500 ml) effected. The combined organic extracts were washed with saturated aqueous sodium bicarbonate solution (500 ml), dried (MgSO 4 ) and evaporated under reduced pressure. The residue was dissolved in a mixture of tetrahydrofuran (200 ml) and water (50 ml), then the solution heated at 60° C. for 16 hours, allowed to cool and the bulk of the tetrahydrofuran removed by evaporation under reduced pressure. Extraction with ethyl acetate (2×300 ml) was effected, then the combined organic extracts washed sequentially with water (100 ml) and brine (2×100 ml), dried (MgSO 4 ) and evaporated under reduced pressure. The resulting residue was crystallised from propan-2-ol to provide the title compound as a white solid, m.p. 225-226° C. &dgr;(CDCl 3 ): 6.08 (br.s,2H), 7.84 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 450.1; C 13 H 4 Cl 3 F 5 N 4 O&plus;NH 4 requires 450.0. 
 PREPARATION 22 
 4-Chlorodifluoroacetyl-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole t-Butyl nitrite (12.45 ml) was added dropwise to a stirred solution of the title compound of Preparation 21 (13.7 g) in tetrahydrofuran (100 ml) and the mixture heated at 60° C. for 22 hours, allowed to cool and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel (50 g), using dichloromethane as eluant, followed by trituration with hexane (5×50 ml) and crystallisation from dichloromethane, to furnish the title compound as a white solid, m.p. 124-125° C. &dgr;(CDCl 3 ): 7.83 (s,2H), 8.27 (s,1H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 435.2; C 13 H 3 Cl 3 F 5 N 3 O&plus;NH 4 requires 435.0. 
 PREPARATION 23 
 4-(3-Chloro-3,3-difluoropropen-2-yl)-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole A 2.5M solution of n-butyllithium in hexane (3.8 ml) was added dropwise to a stirred suspension of methyltriphenylphosphonium iodide (3.817 g) in tetrahydrofuran (20 ml) under nitrogen at room temperature. The resulting reddish brown solution was added dropwise, under nitrogen, to a stirred solution of the title compound of Preparation 22 (3.95 g) in tetrahydrofuran (30 ml) at room temperature and the reaction mixture stirred for 1 hour. Water (50 ml) was then added, extraction with ether (2×50 ml) effected and the combined organic extracts dried (Na 2 SO 4 ) and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel (100 g), using hexane:dichloromethane (1:1) as eluant, followed by crystallisation from propan-2-ol, to afford the title compound as a white solid, m.p. 113-114° C. &dgr;(CDCl 3 ): 6.12 (s, 1 H), 6.20 (s,1H), 7.75 (s,2H), 7.80 (s,1H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 433.0; C 14 H 5 Cl 3 F 5 N 3 &plus;NH 4 requires 433.0. 
 PREPARATION 24 
 4-(3-Chlorodifluoromethyl-1-pyrazolin-3-yl)-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole A solution of diazomethane in ether (7.0 ml, 2.3mmol) was added slowly to a stirred solution of the title compound of Preparation 23 (800 mg) in ether (10 ml) at room temperature and the mixture stirred for 1 hour. The excess diazomethane and solvent were evaporated under a steady stream of nitrogen to give the title compound as a white solid. &dgr;(CDCl 3 ): 2.27 (m,1H), 2.58 (m,1H), 4.90 (m,2H), 7.75 (s,2H), 8.06 (s,1H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 474.8; C 15 H 7 Cl 3 F 5 N 5 &plus;NH 4 requires 475.0. 
 PREPARATION 25 
 5-Amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-propanoylpyrazole p-Toluenesulphonic acid monohydrate (2.92 g) was added to a stirred solution of 5-amino-3-cyano-1-(2,6-dichloro-4-trifuoromethylphenyl)-4-(prop-1-yn-1-yl)pyrazole (WO-A-97/07102; 2.1 g) in acetonitrile (40 ml) and the mixture stirred at room temperature for 1 hour. Further p-toluenesulphonic acid monohydrate (1.0) was added and this mixture stirred at room temperature for 16 hours. Further acetonitrile (20 ml) and yet more p-toluenesulphonic acid monohydrate (1.0 g) were added and stirring continued for 1 hour, then the reaction mixture was poured into saturated aqueous sodium bicarbonate solution (500 ml) and extracted with ether (2×100 ml). The combined organic extracts were washed with brine (100 ml), dried (Na 2 SO 4 ) and evaporated under reduced pressure, then the residue purified by column chromatography on silica gel (70 g), using dichloromethane as eluant, to yield the title compound as a pale brown solid, m.p. 167-169° C. &dgr;(CDCl 3 ): 1.26 (t,3H), 3.03 (q,2H), 5.83 (br.s,2H), 7.80 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 377.2; C 14 H 9 Cl 2 F 3 N 4 O&plus;H requires 377.0. 
 PREPARATION 26 
 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-propanoylpyrazole t-Butyl nitrite (0.66 ml) was added dropwise to a stirred solution of the title compound of Preparation 25 (1.2 g) in tetrahydrofuran (30 ml) and the mixture stirred at room temperature for 1 hour. Further t-butyl nitrite (0.3 ml) was added and the mixture stirred at room temperature for 1 hour. Next, the reaction misture was heated at 60° C. for 10 minutes, allowed to cool and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel (50 g), using dichloromethane as eluant, to provide the title compound as a very pale yellow solid, m.p. 143° C. &dgr;(CDCl 3 ): 1.28 (m,3H), 3.01 (q,2H), 7.80 (s,2H), 8.15 (s,1H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 379.3; C 14 H 8 Cl 2 F 3 N 3 O&plus;NH 4 requires 379.0. 
 PREPARATION 27 
 4-(But-1-en-2-yl)-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole Obtained from the title compound of Preparation 27, by analogy with Preparation 23 but using hexane:dichloromethane (2:3) as chromatographic eluant and no subsequent crystallisation, as a white solid, m.p. 104-105° C. &dgr; (CDCl 3 ): 1.19 (t,3H), 2.47 (q,2H), 5.29 (s,1H), 5.74 (s,1H), 7.60 (s,1H), 7.79 (s,2H). MS (electrospray): M/Z &lsqb;M&plus;H&rsqb; 360.1; C 15 H 10 Cl 2 F 3 N 3 &plus;H requires 360.0. 
 PREPARATION 28 
 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-pentafluoropropanoylpyrazole A 2.5M solution of n-butyllithium in hexane (2.78m1) was added to a stirred solution of the title compound of Preparation 3 (3.0 g) in tetrahydrofuran (80 ml) at −80° C., under nitrogen, at such a rate that the temperature of the reaction mixture did not exceed −73° C. The mixture was stirred at −73° C. for 10 minutes and then a solution of methyl pentafluoropropionate (0.89 ml) in tetrahydrofuran (5 ml) was added at such a rate that the temperature of the reaction mixture did not exceed −75° C. Upon completion of the addition, the mixture was allowed to warm to room temperature over a period of 1.5 hours, then water (100 ml) added and the resulting mixture extracted with ethyl acetate (2×80 ml). The combined organic layers were dried (Na 2 SO 4 ) and evaporated under reduced pressure, then the residue purified by column chromatography on silica gel (150 g), using hexane:dichloromethane (1:9) as eluant, and further purified by column chromatography on silica gel (50 g), using hexane:ether (9:1) as eluant, to furnish the title compound as a white solid, m.p. 120° C. &dgr;(CDCl 3 ): 7.80 (s,2H), 8.25 (s,1H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 468.9; C 14 H 3 Cl 2 F 8 N 3 O&plus;NH 4 requires 469.0. 
 PREPARATION 29 
 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(3,3,4,4,4-pentafluorobut-1-en-2-yl)pyrazole Obtained from the title compound of Preparation 28, by analogy with Preparation 23 but without any post-chromatographic crystallisation, as a white solid, m.p. 107-108° C. &dgr;(CDCl 3 ): 6.23 (s,1H), 6.43 (s,1H), 7.73 (s,1H), 7.79 (s,2H). MS (electrospray): M/Z &lsqb;M&plus;H&rsqb; 450.0; C 15 H 5 Cl 2 F 8 N 3 &plus;H requires 450.0. 
 PREPARATION 30 
 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(3-pentafluoroethyl-1-pyrazolin-3-yl)pyrazole Obtained from the title compound of Preparation 29, by analogy with Preparation 24, as a white solid. &dgr;(CDCl 3 ): 2.26 (m,1H), 2.61 (m,1H), 4.83 (m,2H), 7.76 (s,2H), 7.98 (s,1H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 491.8; Cl 6 H 7 Cl 2 F 8 N 5 &plus;H requires 492.0. 
 PREPARATION 31 
 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-heptafluorobutanoylpyrazole Obtained from the title compound of Preparation 3 and methyl heptafluorobutyrate, by analogy with Preparation 28 but using hexane:ether (2:3) as eluant in the first chromatographic purification step and an elution gradient of hexane:ether (19:1 to 9:1) in the second such step, as a pale yellow solid, m.p. 102-103° C. &dgr;(CDCl 3 ): 7.80 (s,2H), 8.24 (s,1H),. MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 518.7; C 15 H 3 Cl 2 F 10 ON 3 O&plus;NH 4 requires 519.0. 
 PREPARATION 32 
 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(3,3,4,4,5,5,5-heptafluoropent-1-en-2-yl)pyrazole Obtained from the title compound of Preparation 31, by analogy with Preparation 23 but using dichloromethane as eluant in a first chromatographic purification step and hexane:dichloromethane (1:1) as eluant in a second such step, with no subsequent crystallisation, as a white solid, m.p. 109-110° C. &dgr; (CDCl 3 ): 6.24 (s,1H), 6.43 (s,1H), 7.73 (s,1H), 7.80 (s,2H). MS (electrospray): M/Z &lsqb;M&plus;H&rsqb; 500.0; C 18 H 5 Cl 2 F 10 N 3 &plus;NH requires 500.0. 
 PREPARATION 33 
 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(3-heptafluoropropyl-1-pyrazolin-3-yl)pyrazole Obtained from the title compound of Preparation 32, by analogy with Preparation 24, as a white solid. &dgr;(CDCl 3 ): 2.36 (m,1H), 2.58 (m,1H), 4.80 (m,1H), 4.87 (m,1H), 7.77 (s,2H), 7.98 (s,1H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 559.3; C 17 H 7 Cl 2 F 10 ON 5 &plus;NH 4 requires 559.0. 
 PREPARATION 34 
 5-Amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylohenyl)-4-(3,3,3-trifluoropropen-2-yl)pyrazole A solution of 3,3,3-trifluoropropen-2-yl zinc bromide:N,N,N′,N′-tetramethylethylenediamine complex in tetrahydrofuran (J.Org.Chem., 1991, 56, 7336; 4.5 ml, 5 mmol) was added to a stirred solution of the title compound of Preparation 1 (1.0 g) and tetrakis(triphenylphosphine)palladium(O) (60 mg) in anhydrous tetrahydrofuran (1.0 ml), under nitrogen, and the reaction mixture heated at 55° C. for 20 hours, allowed to cool and poured into stirred hexane (50 ml). The resulting mixture was filtered, the filter pad washed with ether (50 ml) and the combined organic solutions evaporated under reduced pressure. The residue was purified by two column chromatography operations on silica gel (40g, then 10 g), firstly using hexane:ether:dichloromethane (4:1:1) as eluant then, sequentially, hexane, hexane:ether (4:1) and hexane:ether:dichloromethane (4:1:1) as eluants, to afford the title compound as a very pale yellow solid, m.p. 147-148° C. &dgr;(CDCl 3 ): 3.93 (br.s,2H), 5.96 (s 1H), 6.24 (s,1H), 7.78 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 415.0; C 14 H 6 Cl 2 F 6 N,&plus;H requires 415.0. 
 PREPARATION 35 
 5-Amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(3-trifluoromethyl-1-pyrazolin-3-yl)pyrazole Obtained from the title compound of Preparation 34, by analogy with Preparation 24, as a white solid. &dgr;(CDCl 3 ): 2.28 (m,1H), 2.60 (m,1H), 4.77 (br.s,2H), 4.77 (m,1H), 5.02 (m,1H), 7.78 (s,1H), 7.82 (s,1H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 457.0; C 15 H 8 Cl 2 F 6 N 6 &plus;H requires 457.0. 
 PREPARATION 36 
 5-Amino-1-&lsqb;(3-chloro-5-trifluoromethyl)pyridin-2-yl&rsqb;-3-cyano-4-iodopyrazole N-Iodosuccinimide (10 g) was added to a stirred solution of 5-amino-1-&lsqb;(3-chloro-5-trifluoromethyl)pyridin-2yl&rsqb;-3-cyanopyrazole (EP-A-0500209; 7.91 g) in acetonitrile (100 ml) at room temperature. After 16 hours, the reaction mixture was evaporated under reduced pressure, the residual solid dissolved in dichloromethane and the resulting solution washed successively with aqueous sodium thiosulphate solution (×2), water and saturated brine, dried (MgSO 4 ) and evaporated under reduced pressure to give the title compound as a pink solid, m.p. 107-108° C. &dgr;(CDCl 3 ) 5.15 (br.s,2H), 8.20 (s,1H), 8.67 (s,1H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 413.1; C 10 H 4 CIF 3 IN 5 &plus;H requires 412.9. 
 PREPARATION 37 
 1-&lsqb;(3-Chloro-5-trifluoromethyl)pyridin-2-yl&rsqb;-1-3-cyano-4-iodopyrazole A solution of t-butyl nitrite (7.2 ml) in tetrahydrofuran (30 ml) was added dropwise to a stirred mixture of the title compound of Preparation 36 (12.5 g) in tetrahydrofuran (90 ml) gently heated to reflux, then the reaction mixture allowed to cool to room temperature and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel, using hexane:ethyl acetate (4:1) as eluant, to yield the title compound as a yellow solid, m.p. 104-107° C. &dgr;(CDCl 3 ): 8.20 (s,1H), 8.70 (s,1H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 397.8; C 10 H 3 CIF 3 IN 4 &plus;H requires 397.9. 
 PREPARATION 38 
 1-&lsqb;(3-Chloro-5-trifluoromethyl)pyridin-2-yl&rsqb;-3-cyano-4-ethenylpyrazole Tri-n-butyl(vinyl)tin (9.19 g) and tetrakis(triphenylphosphine)palladium(O) (0.3 g) were added to a stirred solution of the title compound of Preparation 37 (10.50 g) in dimethylformamide (100 ml) at room temperature, under nitrogen, and the resulting mixture heated at 75° C. for 16 hours, then allowed to cool. The mixture was evaporated under reduced pressure, the residue partitioned between dichloromethane and water, then the separated organic phase washed successively with water (×3) and saturated brine, dried (MgSO 4 ) and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel, using hexane:ethyl acetate (9:1) as eluant, to provide the title compound as a white solid, m.p. 57.5-58.5° C. &dgr;(CDCl 3 ): 5.50 (d,1H), 5.97 (d,1H), 6.65 (dd,1H), 8.20 (s,1H), 8.35 (s,1H), 8.70 (s,1H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 297.9; C 12 H 6 CIF 3 N 4 &plus;H requires 298.0. 
 PREPARATION 39 
 5-Amino-3-cyano-4-iodo-1-(2,4,6-trichlorophenyl)pyrazole N-Iodosuccinimide (17.67 g) was added portionwise to a stirred solution of 5-amino-3-cyano-1-(2,4,6-trichlorophenyl)pyrazole (U.S. Pat. No. 5,232,940; 22.5 g) in acetonitrile (300 ml) and the resulting mixture stirred at room temperature for 1 hour, then evaporated under reduced pressure. The residue was partially purified by chromatography on silica gel (800 g), using an elution gradient of dichloromethane:ethyl acetate (100:0 to 0:100), to produce a pale brown solid which was further purified as follows. Trituration with hexane (25 ml) provided a residue which was dissolved in dichloromethane (500 ml). This solution was washed with water (500 ml), the aqueous washing back-washed with ethyl acetate (500 ml) and the combined organic solutions dried (Na 2 SO 4 ) and evaporated under reduced pressure to furnish the title compound as a pale brown solid. &dgr;(DMSO d6 ): 6.28 (br.s,2H), 7.98 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 413.0; C 10 H 4 Cl 3 IN 4 &plus;H requires 412.9. 
 PREPARATION 40 
 3-Cyano-4-iodo-1-(2,4,6-trichlorophenyl)pyrazole t-Butyl nitrite (7.13 ml) was added dropwise over 5 minutes to a stirred solution of the title compound of Preparation 39 (15.5 g) in tetrahydrofuran (400 ml), then the mixture stirred at room temperature for 1 hour, warmed to 60° C. over 40 minutes, allowed to cool and evaporated under reduced pressure. The resulting pale red solid was purified by column chromatography on silica gel (500 g), using dichloromethane as eluant, to afford the title compound as a very pale yellow solid. &dgr;(CDCl 3 ): 7.52 (s,2H), 7.67 (s,1H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 414.8; C 10 H 3 Cl 3 IN 3 &plus;NH 4 requires 414.9. 
 PREPARATION 41 
 3-Cyano-4-ethenyl-1-(2,4,6-trichlorophenyl)pyrazole A mixture of the title compound of Preparation 40 (10.8 g), tri-n-butyl(vinyl)tin (20 ml), tetrakis(triphenylphosphine)palladium(O) (1.0 g) and dimethylformamide (60 ml) was stirred at 75° C. for 3 hours, allowed to cool and poured into stirred water (100 ml). The resulting mixture was extracted with ether (2×150 ml) and the combined extracts washed with water (50 ml) and evaporated under reduced pressure. The residue was purified by trituration with hexane (3×25 ml), followed by column chromatography on silica gel (200 g) using an elution gradient of hexane:ethyl acetate (100:0 to 50:50), then crystallisation from hexane-dichloromethane, to give the title compound as a very pale grey solid. &dgr;(CDCl 3 ): 5.46 (d,1H), 5.92 (d,1H), 6.63 (dd,1H), 7.51 (s,2H), 7.62 (s,1H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 315.0; C 12 H 6 Cl 3 N 3 &plus;NH 4 requires 315.0. 
 PREPARATION 42 
 5-Amino-3-cyano-4-(2,2-dibromocyclopropyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole A vigorously stirred mixture of the title compound of Preparation 2 (1.0 g), bromoform (13 ml), benzyltriethylammonium chloride (0.075 g), 60% aqueous sodium hydroxide solution (2 ml), dichloromethane (12 ml) and ethanol (0.5 ml) was heated under reflux for 10 days, then allowed to cool and diluted with water. The separated organic phase was applied to a column of silica gel (10 g) and elution with dichloromethane effected. The crude product obtained from the appropriate fractions was purified by reverse phase HPLC on C18 silica, using acetonitrile:water:methanol (50:40:10) as eluant, to give the title compound as an off-white solid, m.p. 178-179° C. &dgr;(CDCl 3 ): 2.28 (d,2H), 2.61 (t,1H), 3.80 (br.s,2H), 7.8 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 516.4; C 14 H 7 Br 2 Cl 2 F 3 N 4 &plus;H requires 516.84. 
 PREPARATION 43 
 3-Cyano-4-(2,2-dibromocyclopropyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole Ethanol (0.1 ml) and a solution of sodium hydroxide (0.29 g) in water (0.5 ml) were added to a stirred solution of the title compound of Preparation 4 (0.6 g) and bromoform (1.83 g) in dichloromethane (2 ml), followed by benzyltriethylammonium chloride (0.01 g). The reaction mixture was stirred, successively, at room temperature for 18 hours, at 50° C. for 5 hours, at room temperature for 48 hours, at 50° C. for 4 hours and at room temperature for 18 hours, then partitioned between dichloromethane (100 ml) and water (100 ml). The organic phase was separated, dried (MgSO 4 ) and evaporated under reduced pressure to provide an oil which was purified by column chromatography on silica gel (10 g), using hexane:dichloromethane (3:7) as eluant, followed by crystallisation of the required material from hexane. The title compound was thus obtained as a white solid, m.p. 121-123° C. &dgr; (CDCl 3 ): 2.02 (t,1H), 2.34 (dd,1H), 2.88 (dd,1H), 7.53 (s,1H), 7.78 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 518.9; C 14 H 6 Br 2 Cl 2 F 3 N 3 &plus;NH 4 requires 518.86. 
 PREPARATIONS 44A AND 44B 
 A. (−)-3-Cyano-4-(2,2-dibromocyclopropyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole and 
 B. (&plus;)-3-Cyano-4-(2,2-dibromocyclopropyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole The title compound of Preparation 43 (28.5 mg) was resolved by chiral HPLC using a Chiralpak (Trade Mark) AD column (25 cm×2 cm), a mixture of hexane: propan-2-ol (93:7) as eluant and an elution rate of 9 ml/minute. The (−)-enantiomer (A) eluted first and was obtained as a white crystalline solid, m.p. 132.5-135° C. &lsqb;&agr;&rsqb; D 25 −42.54° (c&equals;1.5 mg/ml, methanol). The (&plus;)-enantiomer (B) eluted second and was obtained as a white crystalline solid, m.p. 132.5-134° C. &lsqb;&agr;&rsqb; D 25 &plus;44.02° (c&equals;3.5 mg/ml, methanol). It was determined by X-ray crystallographic analysis that this latter enantiomer possesses the R-configuration. 
 PREPARATION 45 
 3-Cyano-4-(2,2-dichlorocyclopropyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole Benzyltriethylammonium chloride (0.01 g) and ethanol (0.015 ml) were added to a stirred solution of the title compound of Preparation 4 (0.46 g) in chloroform (0.66 ml). 50% Aqueous sodium hydroxide solution (0.25 ml) was then added and the reaction mixture stirred at 60° C. for 1 month. The resulting mixture was partitioned between dichloromethane and water, then the organic phase separated, dried (MgSO 4 ) and evaporated under reduced pressure. The brown gum thus obtained was purified by column chromatography on silica gel (10 g), using dichloromethane as eluant, followed by reverse phase HPLC on C18 silica, using acetonitrile:water:methanol (50:40:10) as eluant. Crystallisation of the required material from hexane furnished the title compound as colourless plates, m.p. 123-126° C. &dgr;(CDCl 3 ): 1.84 (t, 1H), 2.20 (dd,1H), 2.85 (dd,1H), 7.53 (s,1H), 7.78 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 430.6; C 14 H 6 Cl 4 F 3 N 3 &plus;NH 4 requires 430.96. 
 PREPARATION 46 
 5-Amino-3-cyano-4-(2,2-dibromocyclopropyl)-1-(2,6-dichloro-4-pentafluorothiophenyl)pyrazole Bromoforrn (6.4 ml), followed by ethanol (0.1 ml) and a solution of sodium hydroxide (0.29 g) in water (0.5 ml), were added to a stirred solution of the title compound of Preparation 6 (0.35 g) in dichloromethane (2 ml). Benzyltriethylammonium chloride (0.01 g) was next added and the reaction mixture stirred at 50° C. for 13 days, then allowed to cool. The resulting mixture was evaporated under reduced pressure and the residue partitioned between dichloromethane and water. The organic phase was separated and combined with ethyl acetate extracts of the aqueous phase, then the combined organic solutions were washed with brine, dried and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel, using dichloromethane as eluant, followed by reverse phase HPLC on C18 silica gel, using acetonitrile:water:methanol (60:30:10) as eluant, to afford the title compound as a white solid, m.p. 178-180° C. &dgr;(CDCl 3 ): 2.29 (d,2H), 2.60 (t,1H), 3.89 (br.s,2H), 7.93 (d,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 574.7; C 13 H 7 Br 2 Cl 2 F 5 N 4 S&plus;H requires 574.81. 
 PREPARATION 47 
 3-Cyano-4-(2,2-dibromocyclopropyl)-1-(2,6-dichloro-4-pentafluorothiophenyl)pyrazole Obtained as a white foam from the title compound of Preparation 8 by analogy with Example 5, but using hexane:dichloromethane (1:1) as eluant in the initial column chromatography purification step. &dgr;(CDCl 3 ): 2.01 (t,1H), 2.34 (dd,1H), 2.88 (dd,1H), 7.54 (s,1H), 7.91 (d,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 576.8; C 13 H 6 Br 2 Cl 2 F 5 N 3 S&plus;NH 4 requires 576.83. 
 PREPARATION 48 
 3-Cyano-4-cyclopropyl-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole A 0.2M solution of diazomethane in ether (25 ml) was added over 25 minutes to a stirred solution of the title compound of Preparation 4 (0.332 g) and palladium(II) acetate (0.01 g) in ether (10 ml) and the mixture stirred at room temperature for 18 hours. The reaction mixture was treated with additional quantities of the ethereal diazomethane solution (25 ml) and palladium(II) acetate (0.01 g), stirred for 24 hours, further treated with the ethereal diazomethane solution (50 ml) and palladium(II) acetate (0.01 g), stirred for 24 hours more, then evaporated under reduced pressure. The residue was purified by column chromatography on silica gel (5 g), using dichloromethane as eluant, followed by reverse phase HPLC on C18 silica, using acetonitrile:water:methanol (50:45:5) as eluant, to give the title compound as a white solid, m.p. 124° C. &dgr;(CDCl 3 ): 0.77 (m,2H), 1.07 (m,2H), 1.89 (m,1H), 7.29 (s,1H), 7.74 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 362.8; C 14 H 8 Cl 2 F 3 N 3 &plus;NH 4 requires 363.04. 
 PREPARATION 49 
 3-Cyano-4-(2,2-dibromo-1-methylcyclopropyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole A solution of the title compound of Preparation 14 (0.25 g) and phenyltribromomethylmercury (0.575 g) in toluene (5 ml) was heated at 70° C. for 4 hours, allowed to cool, filtered and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel, using hexane:dichloromethane (1:1) as eluant, followed by reverse phase HPLC on C18 silica, using acetonitrile:water: methanol (60:30:10) as eluant, to yield the title compound as a white solid, m.p. 133-134° C. &dgr;(CDCl 3 ): 1.83 (s,3H), 1.92 (d,1H), 2.28 (d,1H), 7.59 (s,1H), 7.78 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 533.0; C 15 H 8 Br 2 Cl 2 F 3 N 3 &plus;NH 4 requires 532.88. 
 PREPARATION 50 
 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(1-methylcyclopropyl)pyrazole A 0.007M solution of diazomethane in ether (20 ml) was added in two equal portions to a stirred solution of the title compound of Preparation 14 (0.346 g) and palladium(II) acetate (0.01 g) in ether (10 ml) and the mixture stirred at room temperature for 48 hours, then filtered. The reaction mixture was treated with additional quantities of the ethereal diazomethane solution (20 ml) and palladium(II) acetate (0.01 g), stirred for 24 hours and filtered, then this cycle repeated. The reaction mixture was further treated with the ethereal diazomethane solution (20 ml) and palladium(II) acetate (0.01 g), stirred for 5 days, filtered and evaporated under reduced pressure. Crystallisation of the residue from cyclohexane provided the title compound as a yellow solid, m.p. 138-139° C. &dgr;(CDCl 3 ): 0.86 (m,2H), 1.04 (m,2H), 1.50 (s,3H), 7.41 (s,1H), 7.74 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 359.8; C 15 H 10 Cl 2 F 3 N 3 &plus;H requires 360.03. 
 PREPARATION 51 
 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(2 2-difluorocyclopropyl)pyrazole A solution of the title compound of Preparation 15 (0.507 g) and rhodium(II) acetate dimer (0.045 g) in anhydrous dichloromethane (7 ml) was placed in a glass-lined bomb (50 ml capacity) which was then flushed twice with nitrogen. The reaction vessel was charged with 1,1-difluoroethylene and the reaction mixture heated at 50° C. and 2068 kPa (300 psi) for 24 hours, then allowed to stand at room temperature for 18 hours. The resulting mixture was purified by column chromatography on silica gel (50 g), using dichloromethane as eluant, followed by repeated reverse phase HPLC on C18 silica, using acetonitrile:water (55:45) as eluant, to provide the title compound as a white amorphous solid. &dgr;(CDCl 3 ): 1.58 (m,1H), 2.16 (m,1H), 2.76 (m,1H), 7.50 (s,1H), 7.78 (s,2H). MS (APCI): M/Z &lsqb;M&plus;H&rsqb; 382.0; C 14 H 6 Cl 2 F 5 N 3 &plus;H requires 381.99. 
 PREPARATIONS 52A AND 52B 
 A. 4-(c-2-Bromo-r-1-cyclopropyl)-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole and 
 B. 4-(t-2-Bromo-r-1-cyclopropyl)-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole Tri-n-butyltin hydride (0.9 g) was added dropwise, via a syringe, to a stirred solution of the title compound of Preparation 43 (0.504 g) in toluene (10 ml) at −10° C. The reaction mixture was allowed to warm to room temperature, stirred for 5 hours, kept at −20° C. for 3 days, allowed to warm to room temperature again and then treated with more tri-n-butyltin hydride (0.9 g). This mixture was stirred for a further 24 hours, treated with water and then, after 30 minutes, the aqueous phase was separated and extracted with dichloromethane. The combined organic phases were dried and evaporated under reduced pressure to provide a brown oil which was purified by column chromatography on silica gel, using hexane:dichloromethane (4:1) and then dichloromethane as eluants, followed by crystallisation of the required product from diprop-2-yl ether, to yield isomer A as a greyish-white solid, m.p. 120.5-121 C. &dgr;(CDCl 3 ): 1.22 (m, 1H), 1.82 (m, 1H), 2.29 (m, 1H), 3.40 (m, 1H), 7.47 (s,1H), 7.78 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 441.0; C 14 H 7 BrCl 2 F 3 N 3 &plus;NH 4 requires 440.95. Purification of the crvstallisation mother liquor by reverse phase HPLC on C18 silica, using acetonitrile:water:methanol (50:40:10) as eluant, furnished isomer B as a greyish-white solid, m.p. 126° C. &dgr;(CDCl 3 ): 1.59 (m,1H), 1.62 (m,1H), 2.40 (m,1H), 3.14 (m,1H), 7.39 (s,1H), 7.78 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 441.4; C 14 H 7 BrCl 2 F 3 N 3 &plus;NH 4 requires 440.95. 
 PREPARATION 53 
 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(1-trifluoromethylcyclopropyl)pyrazole A solution of the title compound of Preparation 18 (27 g) in xylene (250 ml) was heated under gentle reflux for 16 hours, then the solvent removed by evaporation under reduced pressure. The resulting residue was purified by column chromatography on silica gel (1 Kg), using hexane and then hexane: ether (8:1) as eluants, followed by crystallisation from cyclohexane, to furnish the title compound as a white solid, m.p. 141° C. &dgr;(CDCl 3 ): 1.24 (m,2H), 1.52 (m,2H), 7.72 (s,1H), 7.78 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 431.3; C 15 H 7 Cl 2 F 6 N 3 &plus;NH 4 requires 431.0. 
 PREPARATION 54 
 5-Chloro-3-cyano-4-(2,2-dibromocyclopropyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole To a stirred solution of the title compound of Preparation 20 (0.288 g) in dichloromethane (1 ml) was added bromoform (0.275 ml) followed by a solution of sodium hydroxide (0.126 g) in water (0.25 ml) and ethanol (0.05 ml). Benzyltriethylammonium chloride (0.006 g) was then added and the reaction mixture vigorously stirred at room temperature for 48 hours, heated at 50° C. for 7 hours and then stirred at room temperature for 24 hours. After further heating at 50° C. for 24 hours, bromoform (0.275 ml), a solution of sodium hydroxide (0.126 g) in water (0.25 ml) and ethanol (0.05 ml) were added and heating continued for 72 hours. The reaction mixture was cooled, partitioned between ether and water and the aqueous phase separated and extracted with ether (×2). The combined extracts were. washed with brine, dried (Na 2 SO 4 ) and evaporated under reduced pressure, then the residue purified by column chromatography on silica gel, using hexane:dichloromethane (3:2) as eluant, followed by crystallisation from hexane, to afford the title compound as a white solid, m.p. 103.5-104.2° C. &dgr;(CDCl 3 ): 2.31 (dd,1H), 2.42 (t,1H), 2.78 (dd,1H), 7.80 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 552.9; C 14 H 5 Br 2 Cl 3 F 3 N 3 &plus;NH 4 requires 552.82. 
 PREPARATION 55 
 4-(1-Chlorodifluoromethylcyclopropyl)-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole Obtained from the title compound of Preparation 24, by analogy with Preparation 53 but heating for 4 hours, using hexane:ether (8:1) as chromatographic eluant and with no subsequent crystallisation, as a white solid, m.p. 124-125° C. &dgr;(CDCl 3 ): 1.24 (m,2H), 158 (m,2H), 7.74 (s,1H), 7.74 (s,2H) MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 446.9; C, 5 H,Cl 3 F 5 N 3 &plus;NH 4 requires 447.0. 
 PREPARATION 56 
 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(1-ethylcyclopropyl)pyrazole A 0.467M solution of diazomethane in ether (30 ml) was added over 2 minutes to a stirred solution of the title compound of Preparation 27 (3 g) and palladium(II) acetate (0.025 g) in ether (5 ml) and the resulting mixture stirred at room temperature for 18 hours. The reaction mixture was filtered, treated with additional quantities of the ethereal diazomethane solution (30 ml) and palladium(II) acetate (0.025 g), stirred for 4 hours more, filtered then further treated with the ethereal diazomethane solution (30 ml) and palladium(II) acetate (0.025 g), stirred for 40 hours more, filtered then further treated with the ethereal diazomethane solution (30 ml) and palladium(II) acetate (0.025 g), stirred for 88 hours more, filtered then further treated with the ethereal diazomethane solution (30 ml) and palladium(II) acetate (0.025 g), stirred for 2 hours more, filtered then further treated with the ethereal diazomethane solution (30 ml) and palladium(II) acetate (0.025 g), stirred for 18 hours more and then evaporated under reduced pressure. The residue was purified by reverse phase HPLC on C18 silica, using acetonitrile:water (60:40) as eluant, to provide the title compound as a white solid, m.p. 118-11 9° C. &dgr;(CDCl 3 ): 0.80 (m,2H), 0.90 (m,5H), 1.63 (m,2H), 7.44 (s,1H), 7.77 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 390.8; C 16 H 12 Cl 2 F 3 N 3 &plus;NH 4 requires 391.1. 
 PREPARATION 57 
 3-Cyano-4-(2,2-dibromo-1-ethylcyclopropyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole A solution of the title compound of Preparation 27 (105 mg) and phenyltribromomethylmercury (160 mg) in toluene (4 ml) was heated at 70° C. for 2 hours, then a solution of phenyltribromomethylmercury (180 mg) in toluene (2 ml) was added and the mixture heated at 70° C. for 16 hours, more phenyltribromomethylmercury (230 mg) was added and the mixture heated at 70° C. for 4 hours, yet more phenyltribromomethylmercury (310 mg) was added and the mixture heated at 70° C. for 2 hours, still more phenyltribromomethylmercury (310 mg) was added and the mixture heated at 70° C. for 16 hours, then allowed to cool. The resulting mixture was filtered through silica gel (10 g), using hexane and then dichloromethane as eluants, and the required eluate fractions evaporated under reduced pressure. The residue was purified by column chromatography on silica gel (10 g), using dichloromethane:hexane (1:4) as eluant, followed by reverse phase HPLC on C18 silica, using acetonitrile:water:methanol (60:30:10) as eluant, to furnish the title compound as a white solid, m.p. 107-108° C. &dgr;(CDCl 3 ): 1.04 (t,3H), 1.90 (m,2H), 2.19 (m,2H), 7.62 (s,2H), 7.79 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 530.0; C 16 H 10 Br 2 Cl 2 F 3 N 3 &plus;H requires 529.9. 
 PREPARATION 58 
 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(1-pentafluoroethylcyclopropyl)pyrazole Obtained from the title compound of Preparation 30, by analogy with Preparation 55 but using reverse phase HPLC on C18 silica with acetonitrile:water:methanol (60:30:10) as eluant, as a white solid, m.p. 105-106° C. &dgr;(CDCl 3 ): 1.24 (m,2H), 1.55 (m,2H), 7.67 (s,1H), 7.77 (s,2H). MS (electrospray): M/Z &lsqb;M&plus;H&rsqb; 464.0; C 16 H 7 Cl 2 F 8 N 3 &plus;H requires 464.0. 
 PREPARATION 59 
 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(1-heptafluoropropylcyclopropyl)pyrazole Obtained from the title compound of Preparation 33, by analogy with Preparation 55 but heating for 3 hours and effecting post-chromatographic crystallisation from cyclohexane, as a white solid, m.p. 95-96° C. &dgr;(CDCl 3 ): 1.23 (m,2H), 1.54 (m,2H), 7.65 (s,1H), 7.74 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 514.2; C 17 H 7 Cl 2 F 10 N 3 &plus;H requires 514.0. 
 PREPARATION 60 
 5-Amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-(1-trifluoromethylcyclopropyl)pyrazole A solution of the title compound of Preparation 35 (130 mg) in a mixture of xylene (8 ml) and toluene (1 ml) was heated under gentle reflux for 7 hours, then allowed to stand at room temperature for 16 hours. The solvent was removed by evaporation under reduced pressure and the resulting residue purified by reverse phase HPLC on C18 silica, using acetonitrile:water:methanol (45:45:10) as eluant, to afford the title compound as a white solid, m.p. 178-179° C. &dgr;(CDCl 3 ): 1.13 (m,2H), 1.48 (m,2H), 3.91 (br.s,2H), 7.80 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 429.1; C 15 H 8 Cl 2 F 6 N 4 &plus;H requires 429.0. 
 PREPARATION 61 
 1-&lsqb;(3-Chloro-5-trifluoromethyl)pyridin-2-yl&rsqb;-3-cyano-4-(2,2-dibromocyclopropyl)pyrazole A solution of the title compound of Preparation 38 (0.50 g) and phenyltribromomethylmercury (1.0 g) in toluene (5 ml) was heated at 70° C. under nitrogen for 1.5 hours. More phenyltribromomethylmercury (0.50 g) was added and heating continued for a further 72 hours. The resulting mixture was allowed to cool, partitioned between ether and water, and the aqueous phase separated and extracted with ether (×2). The combined extracts were washed successively with water and saturated brine, dried (MgSO 4 ) and evaporated under reduced pressure. The crude product (0.50 g), a brown oil, was purified by column chromatography on silica gel, using hexane:ethyl acetate (9:1) as eluant, to give the title compound as a yellow solid, m.p. 81-83° C. &dgr;(CDCl 3 ): 2.05 (t,1H), 2.33 (dd,1H), 2.85 (dd,1H), 8.20 (s,1H), 8.23 (s,1H), 8.70 (s,1H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 467.9; C 13 H 6 Br 2 CIF 3 N 4 &plus;H requires 467.9. 
 PREPARATION 62 
 3-AcetylI4-(2,2-dibromocyclopropyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole A solution of the title compound of Preparation 43 (3.42 g) in ether (25 ml) was added to a stirred, ice-cooled mixture of a 3.0M solution of methylmagnesium iodide in ether (2.26 ml) and anhydrous ether (25 ml) under nitrogen, whilst maintaining the reaction temperature below 2° C. The reaction mixture was allowed to warm to room temperature, heated under reflux for 2 hours and then treated with more (0.5 ml) of the 3M ethereal methylmagnesium iodide solution. This mixture was heated under reflux for 1 hour and then stirred at room temperature for 18 hours. A further quantity (1 ml) of the ethereal methylmagnesium iodide solution was added and the resulting mixture heated under reflux for 3 hours, then poured into a stirred mixture of concentrated hydrochloric acid (2 ml) and ice (10 g). Extraction with ether (×3), followed by washing of the combined extracts with brine, drying (MgSO 4 ) and evaporation under reduced pressure, gave the crude product which was purified by column chromatography on silica gel, using hexane:dichloromethane (1:1) as eluant, followed by crystallisation from hexane, to provide the title compound as a pale yellow solid, m.p. 149.5-150.3° C. &dgr;(CDCl 3 ): 1.78 (dd,1H), 2.24 (dd,1H), 2.69 (s,3H), 3.37 (dd,1H), 7.34 (s,1H), 7.78 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 536.3; C 15 H 9 Br 2 Cl 2 F 3 N 2 O&plus;NH 4 requires 535.88. 
 PREPARATION 63 
 4-(2,2-Dibromocyclopropyl)-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-formylpyrazole A 1 M solution of diisobutylaluminium hydride in hexane (1.5 ml) was added dropwise over 5 minutes to a stirred, ice-cooled solution of the title compound of Preparation 43 (0.50 g) in anhydrous tetrahydrofuran (15 ml). After 1 hour, the reaction mixture was treated with a further quantity (2.25 ml) of the hydride solution, stirred for 18 hours and then poured into acidified aqueous methanol. This mixture was extracted with ether (×2), then the combined extracts washed successively with water and brine, dried (MgSO 4 ) and evaporated under reduced pressure. The resulting residue was purified by column chromatography on silica gel, using hexane:ethyl acetate (9:1) as eluant, to afford the title compound as an oil. &dgr;(CDCl 3 ): 1.80 (dd,1H), 2.28 (dd,1H), 3.32 (dd,1H), 7.39 (s,1H), 7.78 (s,2H), 10.19 (s,1H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 504.7; C 14 H 7 Br 2 Cl 2 F 3 N 2 O&plus;H requires 504.83. 
 PREPARATION 64 
 3-Cyano-4-(2,2-dibromocyclopropyl)-1-(2,4,6-trichlorophenyl)pyrazole A mixture of the title compound of Preparation 41 (2.0 g), 96% bromoform stabilised with 1 to 3% ethanol (6.5 ml), sodium hydroxide (1.0 g), water (1.0 ml), ethanol (0.14 ml), dichloromethane (6.5 ml) and benzyltriethylammonium chloride (80 mg) was rapidly stirred under gentle reflux at about 40° C. for 6 hours, then at room temperature for 18 hours and again at about 40° C. for 6 hours. More sodium hydroxide (0.3 g), water (0.6 ml) and quaternary ammonium salt catalyst (130 mg) were added and the reaction mixture vigorously stirred at about 40° C. for 6 hours and then at room temperature for 18 hours. More catalyst (100 mg) was added and the reaction mixture stirred at about 40° C. for 6 hours and then at room temperature for 66 hours. Still more catalyst (100 mg) and more dichloromethane (2.0 ml) were added and the reaction mixture stirred at about 40° C. for 6 hours, at room temperature for 18 hours, at about 40° C. for 7 hours, at room temperature for 18 hours, at about 40° C. for 7 hours and at room temperature for 18 hours. Finally, more 96% bromoform (3.0 ml), 50% aqueous sodium hydroxide solution (0.5 ml), dichloromethane (3.0 ml) and catalyst (150 mg) were added and the resulting mixture stirred at room temperature for 1 week, then partitioned between dichloromethane (100 ml) and water (50 ml). The separated organic phase was washed with water (50 ml), dried (Na 2 SO 4 ) and evaporated under reduced pressure to produce a black gum which was purified by column chromatography on silica gel (100 g), using hexane and then hexane:ether:dichloromethane (8:1:1) as eluants, to afford the title compound as a very pate yellow solid, m.p. 164° C. &dgr;(CDCl 3 ): 2.02 (t,1H), 2.34 (dd,1H), 2.87 (dd,1H), 7.48 (s,1H), 7.51 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 484.6; C 13 H 6 Br 2 Cl 3 N 3 &plus;NH 4 requires 484.8. 
 PREPARATION 65 
 3-Cyano-4-(2,2-dichlorocyclopropyl)-1-(2,4,6-trichlorophenyl)pyrazole A mixture of the title compound of Preparation 41 (2.0 g), chloroform (6.0 ml), sodium hydroxide (1.0 g), water (1.0 ml), ethanol (0.2 ml), dichloromethane (6.5 ml) and benzyltriethylammonium chloride (150 mg) was rapidly stirred at about 40° C. for 66 hours. More sodium hydroxide (0.5 g), water (1.0 ml), dichloromethane (4 ml) and quaternary ammonium salt catalyst (180 mg) were added and the reaction mixture stirred at about 40° C. for 90 hours. Yet more catalyst (150 mg), dichloromethane (5.0 ml), 50% aqueous sodium hydroxide solution (0.5 ml) and chloroform (3.0 ml) were added and the resulting mixture stirred at about 36° C. for 10 days, then partitioned between dichloromethane (100 ml) and water (50 ml). The separated organic phase was washed with water (50 ml), dried (Na 2 SO 4 ) and evaporated under reduced pressure to yield a black gum which was purified by column chromatography on silica gel (80 g), using hexane:ether:dichloromethane (8:1:1) as eluant, to give the title compound as a pale yellow solid, m.p. 157.8° C. &dgr;(CDCl 3 ): 1.85 (t, 1H), 2.19 (dd,1H), 2.85 (dd,1H), 7.49 (s,1H), 7.52 (s,2H). MS (thermospray): &lsqb;M/Z&plus;NH 4 &rsqb; 396.8; C 13 H 6 Cl 5 N 3 &plus;NH 4 requires 396.9. 
 PREPARATION 66 
 5-Amino-3-cyano-4-(2,2-dichlorocyclopropyl)-1-(2,6-dichloro-4-pentafluorothiophenyl)pyrazole A vigorously stirred mixture of 5-amino-3-cyano-1-(2,6-dichloro-4-pentafluorothiophenyl)-4-ethenylpyrazole (WO-A-97/07102; 0.50 g), chloroform (3.0 ml), a solution of sodium hydroxide (0.25 g) in water (0.25 ml), ethanol (2 drops), dichloromethane (2.0 ml) and benzyltriethylammonium chloride (25 mg) was heated under reflux for 18 hours, then more chloroform (3.0 ml) and quaternary ammonium salt catalyst (25 mg) added and stirring under reflux continued for 78 hours. Still more chloroform (3.0 ml) and catalyst (25 mg) were added and the resulting mixture stirred under reflux for 4 days, then partitioned between dichloromethane (30 ml) and water (30 ml). The separated organic phase was washed with water (2×20 ml) and saturated brine (20 ml), dried (Na 2 SO 4 ) and evaporated under reduced pressure to give a dark brown oil. This crude material was purified as follows: (i) pre-absorption onto silica gel (1.5 g) using dichloromethane as solvent, followed by column chromatography on silica gel (20 g) using hexane:ethyl acetate (7:3) as eluant; (ii) reverse phase HPLC on C18 silica, using acetonitrile:water (70:30) as eluant; and (iii) further reverse phase HPLC on C18 silica, using acetonitrile:methanol:water (50:10:40) as eluant; to provide the title compound as an off-white solid, m.p. 90-95° C. &dgr;(CDCl 3 ): 2.23 (m,2H), 2.56 (t,1H), 3.84 (br.s,2H), 7.83 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;H&rsqb; 487.3; C 13 H 7 Cl 4 F N 4 S&plus;H requires 486.9. 
 PREPARATION 67 
 3-Cyano-4-(2,2-dichlorocyclopropyl)-1-(2,6-dichloro-4-pentafluorothiophenyl)pyrazole The reaction was conducted using the procedure of Preparation 66 and 3-cyano-1-(2,6-dichloro-4-pentafluorothiophenyl)-4-ethenylpyrazole (WO-A-97/07102) as starting material. The crude dark brown oil was purified as follows: (i) pre-absorption onto silica gel (1.5 g) using dichloromethane as solvent, followed by column chromatography on silica gel (15 g) using hexane:ether:dichloromethane (8:1:1) as eluant; (ii) trituration of the resulting pale yellow oil with diisopropyl ether, followed by filtration and evaporation under reduced pressure of the filtrate to give a yellow oil which solidified on standing; (iii) reverse phase HPLC on C18 silica, using acetonitrile:water (70:30) as eluant; (iv) further reverse phase HPLC on C18 silica pre-washed with hexane, using hexane and then dichloromethane as eluants; and (v) dissolution of the resulting oil in methanol, then addition of water to the solution until turbid followed by chilling; to furnish the title compound as a white solid, m.p. 78-80° C. &dgr;(CDCl 3 ): 1.87 (t,1H), 2.20 (m,1H), 2.85 (m,1H), 7.53 (s,1H), 7.93 (s,2H). MS (thermospray): M/Z &lsqb;M&plus;NH 4 &rsqb; 489.1; C 13 H 6 Cl 4 F 5 N 3 S&plus;NH 4 requires 488.9.