Guide catheter

A guide catheter includes a hollow elongate shaft defining a channel. The hollow elongate shaft (or a segment thereof) includes an inner tube and a multilayer sheath formed around the inner tube. The multilayer sheath includes an intermediate layer derived from a melt-processible first polyether-block amide material (e.g., PEBAX®) and an outer layer derived from a different second polyether-block amide (e.g. a cross-linked polyether-block amide material). Reinforcing material (such as a braid of reinforcing filament) may be part of the multilayer sheath. The second polyether-block amide layer of the outer layer provides a shrink tube with a shrink temperature range greater than melt temperature range of the first polyether-block amide material of the intermediate layer. The hollow elongate shaft is formed by heating the intermediate and outer layers at a temperature within the shrink temperature range such that the outer shrink tube layer shrinks and the intermediate layer melts to thereby bond the multilayer sheath to the inner tube.

BACKGROUND OF THE INVENTION

1. Field of the Invention

This invention relates broadly to catheters. More particularly, this invention relates to guide catheters for introducing medical devices and/or therapeutic agents into a body of a patient.

2. State of the Art

Guide catheters are used in surgical applications to provide a passageway through which medical devices and/or therapeutic agents may be introduced within the body of a patient. In intravascular and coronary applications, such medical devices typically include balloon dilation catheters, guide wires or other therapeutic devices and the therapeutic agents typically include contrast media or other therapeutic fluids.

A guide catheter includes a follow shaft defining an inner channel through which the medical devices or agents are delivered once the shaft has been inserted into the body. The inner channel typically comprises a lubricous material such as polytetrafluoroethylene (PTFE), commonly known as TEFLON®, together with a metal braid surround and a flexible durable outer sheath. The outer sheath is typically formed from a polyether-block amide material marketed under the trademark PEBAX® which is commercially available from Atofina Chemicals Inc. of King of Prussia, Pa.

The shaft is typically manufactured by placing fluorinated ethylene-propylene (FEP) shrink tubing over an assembly that includes a mandrel with the PTFE inner channel, the metal braid surround, and the PEBAX® outer sheath. The assembly is heated to activate the FEP shrink tubing and melt the PEBAX® outer sheath. The FEP shrink tubing is then removed and discarded, and the mandrel is removed leaving the elongate shaft. The use of such FEP shrink tubing adds significant material costs to the guide catheter. Moreover, the labor and tooling required to remove the FEP shrink tubing adds significant manufacturing costs to the guide catheter.

Thus, there remains a need in the art to provide a guide catheter with lower material and manufacturing costs. The present invention fulfills these and other needs, and addresses other deficiencies of the prior art implementations and techniques.

SUMMARY OF THE INVENTION

It is therefore an object of the invention to provide a guide catheter that avoids the high material costs of FEP shrink tubing.

It is another object of the invention to provide a guide catheter that avoids the manufacturing costs of the process steps and tooling required to remove FEP shrink tubing.

It is a further object of the invention to provide a guide catheter than is suitable for a wide variety of applications, including intravascular and coronary applications.

It is also an object of the invention to provide a guide catheter that enables positioning, guiding and use in conjunction with fluoroscopic and/or ultrasonic imaging techniques.

In accord with these objects, which will be discussed in detail below, an improved guide catheter includes a hollow elongate shaft defining a channel adapted to pass medical devices and/or therapeutic agents therethrough. The hollow elongate shaft (or hollow elongate shaft section) includes an inner tube and a multilayer sheath formed on the outer surface of the inner tube. The multilayer sheath includes an intermediate layer derived from a first polyether-block amide material (e.g., PEBAX®) and an outer layer derived from a different polyether-block amide (e.g. a cross-linked polyether-block amide material). Reinforcing material (such as a braid of reinforcing filament) may also be part of the multilayer sheath. Preferably, the second polyether-block amide layer of the outer layer provides a shrink tube with a shrink temperature greater than a glass transition temperature for the first polyether-block amide material of the intermediate layer. In this configuration, the shaft is formed by heating the intermediate layer and outer layer at the shrink temperature such that the outer shrink layer shrinks and the intermediate layer melts to thereby bond the multilayer sheath to the inner tube. The outer shrink tube layer remains as part of the elongate shaft. The inner tube is preferably formed from a lubricous polymeric material such as PTFE or the like.

It will be appreciated that the improved guide catheter of the present invention avoids the high material costs of FEP shrink tubing (or other shrink tubing type) as well as the manufacturing costs of the process steps and tooling required to remove FEP shrink tubing (or other shrink tubing type).

According to one embodiment of the invention, the reinforcing material may include a material that is radio-opaque and/or ecogenic to facilitate positioning, guiding and use in conjunction with fluoroscopic and/or ultrasonic imaging techniques.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

As used herein, the term “melt-processible” means that the given thermoplastic material is processible into final shapes by methods employing heat, such as extrusion, injection molding, hot compression molding, or other means. The term “melt temperature” and “melt temperature range” refers to a temperature and temperature range, respectively, of the heat that is applied to a melt-processible thermoplastic material in processing the material into its finals shape. Finally, the term “shrink temperature” and “shrink temperature range” refers to a temperature and temperature range, respectively, of the heat that is applied to a shrinkable thermoplastic material in processing the material to activate the material (i.e., make it shrink).

Turning now toFIG. 1, there is shown a perspective view of a guide catheter10including a proximal end12, distal end14, and a hollow elongate shaft16extending between the proximal end12and the distal end14. The hollow elongate shaft16defines a channel20(not shown inFIG. 1) through which medical devices and/or therapeutic agents may be introduced within the body of a patient. In intravascular and coronary applications, such medical devices typically include balloon dilation catheters, guide wires or other therapeutic devices and the therapeutic agents typically include contrast media or other therapeutic fluids.

A fitting (or hub)18and possibly a handle19may be coupled to the proximal end12as shown. The elongate shaft16may be formed from a unitary segment, or from multiple segments (for example the segments16A,16B,16C,16D,16E,16F as shown inFIG. 3) that are joined together as is well known. Such multiple segments may have varying flexion characteristics if desired. The elongate shaft16may be formed to provide a straight shape or bent shape depending on the desired application. The elongate shaft16may have a reduced diameter distal tip31at the distal end as shown inFIG. 4and described in U.S. patent app. No. 2004/0073158, incorporated by reference herein in its entirety. The reduced diameter distal tip31facilitates cannulation of a vessel.

FIG. 2is a cross-sectional side view of the hollow elongate shaft16ofFIG. 1(or hollow elongate shaft segment ofFIG. 3) in accordance with the present invention. The channel20is defined by the lumen of an inner tube22, which is formed from a synthetic polymeric material. Preferably, the synthetic polymeric material is lubricious, such as PTFE, polyethylene, or the like, to facilitate passage of devices and/or agents through the channel20formed by the inner tube22. A multilayer sheath23is formed about the outer surface of the inner tube22. The multilayer sheath23includes reinforcing material24, an intermediate layer26formed from a melt-processible polyether-block amide material (e.g., PEBAX®) and an outer layer28formed from a different polyether-block amide material. Preferably, the polyether-block amide layer of the outer layer28provides a shrink tube with a shrink temperature range greater than the melt temperature range of the polyether-block amide material of the intermediate layer26. In this configuration, the elongate shaft is formed by heating the intermediate layer26and outer layer28within the shrink temperature range such that the outer layer shrinks and the intermediate layer melts to thereby bond the multilayer sheath to the inner tube as described below. The outer layer28preferably has a hardness that is substantially similar to the hardness of the intermediate layer26. In addition, the melt-processible polyether-block amide material of the outer layer28is preferably cross-linked and may be formed by processing the same (or similar) polyether-block amide material of the intermediate layer26with ultra-violet radiation or other suitable techniques.

The reinforcing material24may be formed by braiding reinforcing filaments about the outer surface of the inner tube22as is well known. In this configuration, the reinforcing material is typically not a continuous layer about the outer surface of the inner tube as shown, but is wound about the outer surface in a mesh pattern leaving openings to the outer surface of the inner tube. Such reinforcing filaments may be a variety of metallic materials (such as steel), or plastic materials (such as polyester). In addition, radio-opaque material (such as platinum, iridium, gold, tantalum, tungsten carbide and the like) may be used to form the filaments to facilitate fluoroscopic imaging techniques. Echogenic material (such as a composite material of jet milled tungsten carbide and polymeric material as described in U.S. patent app. No. 2004/0073158) may also be used to form the filaments to facilitate guiding of the catheter utilizing ultrasonic imaging techniques. In addition, material that is both radio-opaque and echogenic (e.g., a polymer, such as PEBAX®, together with an appropriate radio-opaque and echogenic filler, such as tungsten carbide particles), may be used to form the filaments of the reinforcing braid.

Similarly, the polyether-block amide layer26and/or the polyether-block amide layer28may have a radio-opaque filler material (such as platinum, iridium, gold, tantalum, tungsten carbide and the like), an echogenic filler material (such as a composite material of jet milled tungsten carbide and polymeric material as described in U.S. patent app. No. 2004/0073158), or a material that is both radio-opaque and echogenic to facilitate guiding of the catheter utilizing fluoroscopic imaging techniques and/or ultrasonic imaging techniques.

Preferably, the elongate shaft16of the guide catheter10is formed as follows. First, the inner tube22is formed by coating a mandrel with a synthetic polymeric material and then extruding the coated mandrel through a die. As set forth above, the synthetic polymeric material is preferably lubricous, such as a PTFE, polyethylene or the like, to facilitate passage of devices through the channel20formed by the inner tube22. Preferably, the mandrel has a diameter of at least 3 French such that the lumen of the inner tube22(which is formed when the mandrel is removed) has a corresponding size. Such sizes are suitable to allow introduction of a broad array of medical devices used in modern intravascular and coronary applications. For example, an inner tube that provides a 3 French lumen provides the necessary clearance for guiding a catheter device having a 1 French outer diameter. Note however that the size of the lumen of the inner tube22may be readily changed (increased or decreased) for the desired application(s).

Reinforcing material24is then formed about the outer surface of the inner tube22. Preferably, the reinforcing material24is formed by braiding reinforcing filaments about the outer surface. In this configuration, the filaments are wound about the outer surface in a mesh pattern leaving openings to the outer surface of the inner tube22. The filaments may be a variety of metallic materials (such as steel), or plastic materials (such as polyester). In addition, radio-opaque material (such as platinum, iridium, gold, tantalum, tungsten carbide and the like) may be used to form the filaments to facilitate fluoroscopic imaging techniques. Echo-visible material (such as a composite material of jet milled tungsten carbide and polymeric material as described in U.S. patent app. No. 2004/0073158) may also be used to form the filaments to facilitate ultrasonic imaging techniques. In addition, material that is both radio-opaque and echogenic (e.g., a polymer, such as PEBAX®, together with an appropriate radio-opaque and echogenic filler, such as tungsten carbide particles), may be used to form the filaments of the reinforcing braid.

The inner tube22with the reinforcing material24applied thereto is coated with a polyether-block amide material and then extruded through a die to form a sheath26. Examples of suitable polyether-block amide materials are marketed under the trademark PEBAX® and commercially available from Atofina Chemicals Inc. of King of Prussia, Pa. More particularly, PEBAX® is a trade name for a family of melt-processible polyether-block amide materials that have good hydrolytic stability and are available in a broad range of stiffnesses. In addition, PEBAX® accepts various colors and fillers (including radio-opaque and/or echogenic fillers. PEBAX® has a melt temperature range between 335° F. and 400° F.

Shrink tubing28formed from a different polyether-block amide material is placed over the assembly (e.g., covering the intermediate sheath26). The polyether-block amide material of the shrink tubing28has a shrink temperature range above the melt temperature range for the intermediate sheath material. An example of suitable material for use in the shrink tubing28is a cross-linked polyether-block amide material, which is found in the shrink tubing marketed under the trademark PALLADIUM PEBAX® HEAT SHRINK TUBING and commercially available from Cobalt Polymers of Colverdale, Calif. This shrink tubing has a shrink temperature range between 340° F. and 600° F. At the higher end of this temperature range, the heat must be applied for a short period of time to avoid degradation of the shrink tubing.

The resulting assembly is heated at a temperature within the shrink temperature range of the tubing28(for example, at a temperature of 340° F. for the PALLADIUM PEBAX® HEAT SHRINK TUBING. This activates the shrink tube layer28(i.e., it shrinks) and the material of the intermediate sheath26melts. As the shrink tube layer28shrinks, it forces the molten material of the intermediate sheath26around the reinforcing material24and through the openings formed by the braid structure to contact the inner tube22, thereby bonding the multilayer sheath structure to the inner tube structure. Note that the shrink tubing layer28remains as part of the final shaft assembly.

The mandrel is then removed from the assembly to form the elongate shaft16. This is preferably accomplished by pulling on the mandrel whereby the lubricious nature of the inner tube22allows the inner tube22to be easily separated from the elongate shaft structure.

The profile and length of the elongate shaft of the guide catheter described herein may be optimized for the intended method of access. For example, the contour of the hollow elongate shaft may be bent to form a curve, hook or compound curve as shown inFIGS. 5,6, and7, respectively. Preferably, such contours are achieved by constraining the elongate shaft in a shaping fixture while heating the shaft16until it assumes the intended contour (e.g., by “heat setting” the shaft16).

The guide catheter shaft structure as described above may be used to form a unitary guide lumen as shown inFIG. 1, or may be used to form a guide lumen segment that is coupled to the other guide lumen segments as shown inFIG. 3. The multiple guide lumen segments may have varying flexion characteristics, different material characteristics (such as different fillers for controlling the radio-opaqueness and/or echogenicity of the segments), and different shapes. Moreover, the reinforcing braid of the guide catheter shaft structure as described above may be omitted to provide for greater flexibility.

Advantageously, the guide catheter shaft (or shaft segment) of the present invention has lower material costs because the PEBAX®-based shrink tubing has a lower cost than the fluorinated ethylene-propylene (FEP) shrink tubing typically used in the prior art devices. The manufacturing process is also simplified because the process and tooling that removes the FEP shrink tubing (or other type shrink tubing) can be avoided. Finally, where PEBAX® is used in commercially-available products, it is likely that regulatory resubmission of the device can be avoided.

There has been described and illustrated herein an embodiment of an improved guide catheter (and improved guide catheter shaft) that employs a flexible intermediate sheath formed from a melt-processible first polyether-block amide material along with an outer sheath formed from a different second polyether-block amide material. The first polyether-block amide material has a melt temperature in the shrink temperature range of the second polyether-block amide material. While particular embodiments of the invention have been described, it is not intended that the invention be limited thereto, as it is intended that the invention be as broad in scope as the art will allow and that the specification be read likewise. Thus, while particular geometries and dimensions of the assembly elements have been disclosed, it will be understood that other geometries and dimensions can be used. Moreover, while particular configurations and materials have been disclosed, it will be appreciated that other configurations and materials could be used as well. It will therefore be appreciated by those skilled in the art that yet other modifications could be made to the provided invention without deviating from its spirit and scope as claimed.