Steerable laser probe

A steerable laser probe may include a handle, an actuation lever, an optic fiber, and a housing tube. The housing tube may have a first housing tube portion having a first stiffness and a second housing tube portion having a second stiffness. The second stiffness may be greater than the first stiffness. The optic fiber may be disposed within the housing tube and within an inner bore of the handle. An actuation of the actuation lever about a pivot pin of the handle may gradually curve the optic fiber. An actuation of the actuation lever about the pivot pin of the handle may gradually straighten the optic fiber.

FIELD OF THE INVENTION

The present disclosure relates to a surgical instrument, and, more particularly, to a steerable laser probe.

BACKGROUND OF THE INVENTION

A wide variety of ophthalmic procedures require a laser energy source. For example, ophthalmic surgeons may use laser photocoagulation to treat proliferative retinopathy. Proliferative retinopathy is a condition characterized by the development of abnormal blood vessels in the retina that grow into the vitreous humor. Ophthalmic surgeons may treat this condition by energizing a laser to cauterize portions of the retina to prevent the abnormal blood vessels from growing and hemorrhaging.

In order to increase the chances of a successful laser photocoagulation procedure, it is important that a surgeon is able aim the laser at a plurality of targets within the eye, e.g., by guiding or moving the laser from a first target to a second target within the eye. It is also important that the surgeon is able to easily control a movement of the laser. For example, the surgeon must be able to easily direct a laser beam by steering the beam to a first position aimed at a first target, guide the laser beam from the first position to a second position aimed at a second target, and hold the laser beam in the second position. Accordingly, there is a need for a surgical laser probe that can be easily guided to a plurality of targets within the eye.

BRIEF SUMMARY OF THE INVENTION

The present disclosure provides a steerable laser probe. In one or more embodiments, a steerable laser probe may comprise a handle, an actuation lever, an optic fiber, and a housing tube. Illustratively, the housing tube may comprise a first housing tube portion having a first stiffness and a second housing tube portion having a second stiffness. In one or more embodiments, the second stiffness may be greater than the first stiffness. Illustratively, the optic fiber may be disposed within the housing tube and within an inner bore of the handle. In one or more embodiments, a portion of the optic fiber may be fixed to an inner portion of the housing tube, e.g., by a biocompatible adhesive or any other suitable means.

Illustratively, an actuation of the actuation lever, e.g., as a result of an application of a force to the actuation lever, may be configured to gradually compress a first housing tube portion of the housing tube. In one or more embodiments, a compression of the first housing tube portion may be configured to gradually curve the housing tube. Illustratively, a gradual curving of the housing tube may be configured to gradually curve the optic fiber.

In one or more embodiments, an actuation of the actuation lever, e.g., as a result of a reduction of a force applied to the actuation lever, may be configured to gradually decompress a first housing tube portion of the housing tube. Illustratively, a decompression of the first housing tube portion may be configured to gradually straighten the housing tube. In one or more embodiments, a gradual straightening of the housing tube may be configured to gradually straighten the optic fiber.

DETAILED DESCRIPTION OF AN ILLUSTRATIVE EMBODIMENT

FIGS. 1A and 1Bare schematic diagrams illustrating a handle100.FIG. 1Aillustrates a top view of handle100. Illustratively, handle100may comprise a handle distal end101and a handle proximal end102. In one or more embodiments, handle100may comprise a handle base110, an actuation channel120having an actuation channel distal end121and an actuation channel proximal end122, and a pivot pin housing130.FIG. 1Billustrates a cross-sectional view of handle100. Illustratively, handle100may comprise an inner bore140, an inner bore distal chamber150, and an optic fiber guide160. Handle100may be manufactured from any suitable material, e.g., polymers, metals, metal alloys, etc., or from any combination of suitable materials.

FIGS. 2A,2B, and2C are schematic diagrams illustrating a housing tube200. In one or more embodiments, housing tube200may comprise a housing tube distal end201and a housing tube proximal end202. Housing tube200may be manufactured from any suitable material, e.g., polymers, metals, metal alloys, etc., or from any combination of suitable materials.FIG. 2Aillustrates a housing tube200oriented to illustrate a first housing tube portion220. Illustratively, first housing tube portion220may have a first stiffness.FIG. 2Billustrates a housing tube200oriented to illustrate a second housing tube portion230. Illustratively, second housing tube portion230may have a second stiffness. In one or more embodiments, the second stiffness may be greater than the first stiffness. Illustratively, first housing tube portion220may comprise a first material having a first stiffness. In one or more embodiments, second housing tube portion230may comprise a second material having a second stiffness. Illustratively, the second stiffness may be greater than the first stiffness.

In one or more embodiments, first housing tube portion220may comprise one or more apertures configured to produce a first stiffness of first housing tube portion220. Illustratively, second housing tube portion230may comprise a solid portion of housing tube200having a second stiffness. In one or more embodiments, the second stiffness may be greater than the first stiffness. Illustratively, first housing tube portion220may comprise one or more apertures configured to produce a first stiffness of first housing tube portion220. In one or more embodiments, second housing tube portion230may comprise one or more apertures configured to produce a second stiffness of second housing tube portion230. Illustratively, the second stiffness may be greater than the first stiffness.

In one or more embodiments, first housing tube portion220may comprise a plurality of slits configured to separate one or more solid portions of housing tube200. Illustratively, a plurality of slits may be cut, e.g., laser cut, into first housing tube portion220. In one or more embodiments, first housing tube portion220may comprise a plurality of slits configured to minimize a force of friction between housing tube200and a cannula, e.g., as housing tube200is inserted into the cannula or as housing tube200is extracted from the cannula. For example, each slit of the plurality of slits may comprise one or more arches configured to minimize a force of friction between housing tube200and a cannula.

FIG. 2Cillustrates an angled view of housing tube200. Illustratively, an optic fiber250may be disposed within housing tube200. In one or more embodiments, optic fiber250may be disposed within housing tube200wherein an optic fiber distal end251may be adjacent to housing tube distal end201. Illustratively, optic fiber250may be disposed within housing tube200wherein a portion of optic fiber250may be adjacent to a portion of first housing tube portion220. In one or more embodiments, a portion of optic fiber250may be fixed to an inner portion of housing tube200, e.g., by a biocompatible adhesive or any other suitable means.

FIG. 3is a schematic diagram illustrating an exploded view of a steerable laser probe assembly300. In one or more embodiments, a steerable laser probe assembly300may comprise a handle100, a housing tube200having a housing tube distal end201and a housing tube proximal end202, an optic fiber250having an optic fiber distal end251and an optic fiber proximal end252, a pivot pin310, an actuation lever320having an actuation lever distal end321and an actuation lever proximal end322, and a light source interface330. Illustratively, light source interface330may be configured to interface with optic fiber proximal end252. In one or more embodiments, light source interface330may comprise a standard light source connector, e.g., an SMA connector.

Illustratively, actuation lever320may comprise a pivot pin guide325. In one or more embodiments, pivot pin310may be disposed within pivot pin housing130and pivot pin guide325. Illustratively, pivot pin310may be configured to fix a portion of actuation lever320to a portion of handle100. In one or more embodiments, pivot pin310may be fixed in a position within pivot pin housing130. For example, pivot pin310may be fixed in a position within pivot pin housing130, e.g., by an adhesive or any other suitable fixation means.

Illustratively, housing tube200may be fixed to handle100, e.g., housing tube proximal end202may be fixed to handle distal end101. In one or more embodiments, housing tube200may be fixed to handle100, e.g., by an adhesive or any suitable fixation means. Illustratively, optic fiber250may be disposed within inner bore140, actuation channel120, inner bore distal chamber150, optic fiber guide160, and housing tube200. In one or more embodiments, optic fiber250may be disposed within housing tube200wherein optic fiber distal end251may be adjacent to housing tube distal end201. Illustratively, a portion of optic fiber250may be fixed to an inner portion of housing tube200, e.g., by a biocompatible adhesive or by any other suitable fixation means.

In one or more embodiments, a portion of optic fiber250may be fixed to a portion of actuation lever320, e.g., a portion of optic fiber250may be fixed to actuation lever proximal end322. Illustratively, an application of a force to actuation lever320may be configured to actuate actuation lever320, e.g., within actuation channel120. In one or more embodiments, an application of a force to actuation lever320may be configured to rotate actuation lever320about pivot pin310. Illustratively, an application of a force to actuation lever320may be configured to rotate actuation lever distal end321and actuation lever proximal end322about pivot pin310, e.g., in a clockwise direction. In one or more embodiments, an application of a force to actuation lever320may be configured to actuate actuation lever distal end321away from handle proximal end102and configured to actuate actuation lever proximal end322towards handle proximal end102. For example, an application of a force to actuation lever320may be configured to retract actuation lever proximal end322relative to handle base110.

Illustratively, an actuation of actuation lever proximal end322towards handle proximal end102, e.g., due to an application of a force to actuation lever320, may be configured to retract optic fiber250relative to housing tube200. In one or more embodiments, a retraction of optic fiber250relative to housing tube200may be configured to cause optic fiber250to apply a compressive force to an inner portion of housing tube200. Illustratively, an application of a compressive force to an inner portion of housing tube200may be configured to gradually compress a portion of housing tube200, e.g., a first housing tube portion220of housing tube200. In one or more embodiments, a gradual compression of a portion of housing tube200may be configured to cause housing tube200to gradually curve. Illustratively, a gradual curving of housing tube200may be configured to gradually curve optic fiber250.

In one or more embodiments, a reduction of a force applied to actuation lever320may be configured to actuate actuation lever320, e.g., within actuation channel120. Illustratively, a reduction of a force applied to actuation lever320may be configured to rotate actuation lever320about pivot pin310. In one or more embodiments, a reduction of a force applied to actuation lever320may be configured to rotate actuation lever distal end321and actuation lever proximal end322about pivot pin310, e.g., in a counter-clockwise direction. Illustratively, a reduction of a force applied to actuation lever320may be configured to actuate actuation lever distal end321towards handle proximal end102and configured to actuate actuation lever proximal end322away from handle proximal end102. For example, a reduction of a force applied to actuation lever320may be configured to extend actuation lever proximal end322relative to handle base110.

In one or more embodiments, an actuation of actuation lever proximal end322away from handle proximal end102, e.g., due to a reduction of a force applied to actuation lever320, may be configured to extend optic fiber250relative to housing tube200. Illustratively, an extension of optic fiber250relative to housing tube200may be configured to cause optic fiber250to reduce a compressive force applied to an inner portion of housing tube200. In one or more embodiments, a reduction of a compressive force applied to an inner portion of housing tube200may be configured to gradually decompress a portion of housing tube200, e.g., a first housing tube portion220of housing tube200. Illustratively, a gradual decompression of a portion of housing tube200may be configured to cause housing tube200to gradually straighten. In one or more embodiments, a gradual straightening of housing tube200may be configured to gradually straighten optic fiber250.

FIGS. 4A,4B,4C,4D, and4E illustrate a gradual curving of an optic fiber250.FIG. 4Aillustrates a straight optic fiber400. In one or more embodiments, optic fiber250may comprise a straight optic fiber400, e.g., when actuation lever proximal end322is fully extended relative to handle base110. Illustratively, optic fiber250may comprise a straight optic fiber400, e.g., when first housing tube portion220is fully decompressed. In one or more embodiments, a line tangent to optic fiber distal end251may be parallel to a line tangent to housing tube proximal end202, e.g., when optic fiber250comprises a straight optic fiber400.

FIG. 4Billustrates an optic fiber in a first curved position410. Illustratively, an actuation of actuation lever320, e.g., in a clockwise direction about pivot pin310, may be configured to gradually curve optic fiber250. For example, an actuation of actuation lever320, e.g., due to an application of a force to actuation lever320, may be configured to gradually curve optic fiber250. In one or more embodiments, an application of a force to actuation lever320may be configured to gradually curve optic fiber250from a straight optic fiber400to an optic fiber in a first curved position410. Illustratively, an application of a force to actuation lever320may be configured to gradually retract optic fiber250relative to housing tube200. In one or more embodiments, a gradual retraction of optic fiber250relative to housing tube200may be configured to cause optic fiber250to apply a compressive force to an inner portion of housing tube200. Illustratively, an application of a compressive force to an inner portion of housing tube200may be configured to compress a first housing tube portion220of housing tube200. In one or more embodiments, an application of a compressive force to an inner portion of housing tube200may be configured to gradually curve housing tube200. Illustratively, a gradual curving of housing tube200may be configured to gradually curve optic fiber250, e.g., from a straight optic fiber400to an optic fiber in a first curved position410. In one or more embodiments, a line tangent to optic fiber distal end251may intersect a line tangent to housing tube proximal end202at a first angle, e.g., when optic fiber250comprises an optic fiber in a first curved position410. Illustratively, the first angle may comprise any angle greater than zero degrees. For example, the first angle may comprise a 45 degree angle.

FIG. 4Cillustrates an optic fiber in a second curved position420. Illustratively, an actuation of actuation lever320, e.g., in a clockwise direction about pivot pin310, may be configured to gradually curve optic fiber250. For example, an actuation of actuation lever320, e.g., due to an application of a force to actuation lever320, may be configured to gradually curve optic fiber250. In one or more embodiments, an application of a force to actuation lever320may be configured to gradually curve optic fiber250from an optic fiber in a first curved position410to an optic fiber in a second curved position420. Illustratively, an application of a force to actuation lever320may be configured to gradually retract optic fiber250relative to housing tube200. In one or more embodiments, a gradual retraction of optic fiber250relative to housing tube200may be configured to cause optic fiber250to apply a compressive force to an inner portion of housing tube200. Illustratively, an application of a compressive force to an inner portion of housing tube200may be configured to compress a first housing tube portion220of housing tube200. In one or more embodiments, an application of a compressive force to an inner portion of housing tube200may be configured to gradually curve housing tube200. Illustratively, a gradual curving of housing tube200may be configured to gradually curve optic fiber250, e.g., from an optic fiber in a first curved position410to an optic fiber in a second curved position420. In one or more embodiments, a line tangent to optic fiber distal end251may intersect a line tangent to housing tube proximal end202at a second angle, e.g., when optic fiber250comprises an optic fiber in a second curved position420. Illustratively, the second angle may comprise any angle greater than the first angle. For example, the second angle may comprise a 90 degree angle.

FIG. 4Dillustrates an optic fiber in a third curved position430. Illustratively, an actuation of actuation lever320, e.g., in a clockwise direction about pivot pin310, may be configured to gradually curve optic fiber250. For example, an actuation of actuation lever320, e.g., due to an application of a force to actuation lever320, may be configured to gradually curve optic fiber250. In one or more embodiments, an application of a force to actuation lever320may be configured to gradually curve optic fiber250from an optic fiber in a second curved position420to an optic fiber in a third curved position430. Illustratively, an application of a force to actuation lever320may be configured to gradually retract optic fiber250relative to housing tube200. In one or more embodiments, a gradual retraction of optic fiber250relative to housing tube200may be configured to cause optic fiber250to apply a compressive force to an inner portion of housing tube200. Illustratively, an application of a compressive force to an inner portion of housing tube200may be configured to compress a first housing tube portion220of housing tube200. In one or more embodiments, an application of a compressive force to an inner portion of housing tube200may be configured to gradually curve housing tube200. Illustratively, a gradual curving of housing tube200may be configured to gradually curve optic fiber250, e.g., from an optic fiber in a second curved position420to an optic fiber in a third curved position430. In one or more embodiments, a line tangent to optic fiber distal end251may intersect a line tangent to housing tube proximal end202at a third angle, e.g., when optic fiber250comprises an optic fiber in a third curved position430. Illustratively, the third angle may comprise any angle greater than the second angle. For example, the third angle may comprise a 135 degree angle.

FIG. 4Eillustrates an optic fiber in a fourth curved position440. Illustratively, an actuation of actuation lever320, e.g., in a clockwise direction about pivot pin310, may be configured to gradually curve optic fiber250. For example, an actuation of actuation lever320, e.g., due to an application of a force to actuation lever320, may be configured to gradually curve optic fiber250. In one or more embodiments, an application of a force to actuation lever320may be configured to gradually curve optic fiber250from an optic fiber in a third curved position430to an optic fiber in a forth curved position440. Illustratively, an application of a force to actuation lever320may be configured to gradually retract optic fiber250relative to housing tube200. In one or more embodiments, a gradual retraction of optic fiber250relative to housing tube200may be configured to cause optic fiber250to apply a compressive force to an inner portion of housing tube200. Illustratively, an application of a compressive force to an inner portion of housing tube200may be configured to compress a first housing tube portion220of housing tube200. In one or more embodiments, an application of a compressive force to an inner portion of housing tube200may be configured to gradually curve housing tube200. Illustratively, a gradual curving of housing tube200may be configured to gradually curve optic fiber250, e.g., from an optic fiber in a third curved position430to an optic fiber in a fourth curved position440. For example, a line tangent to optic fiber distal end251may be parallel to a line tangent to housing tube proximal end202, e.g., when optic fiber250comprises an optic fiber in a fourth curved position440.

In one or more embodiments, one or more properties of a steerable laser probe may be adjusted to attain one or more desired steerable laser probe features. For example, a stiffness of first housing tube portion220or a stiffness of second housing tube portion230may be adjusted to vary an amount of actuation of actuation lever320configured to curve housing tube200to a particular curved position. Illustratively, a material comprising first housing tube portion220or a material comprising second housing tube portion230may be adjusted to vary an amount of actuation of actuation lever320configured to curve housing tube200to a particular curved position.

In one or more embodiments, a number of apertures in housing tube200may be adjusted to vary an amount of actuation of actuation lever320configured to curve housing tube200to a particular curved position. Illustratively, a location of one or more apertures in housing tube200may be adjusted to vary an amount of actuation of actuation lever320configured to curve housing tube200to a particular curved position. In one or more embodiments, a geometry of one or more apertures in housing tube200may be adjusted to vary an amount of actuation of actuation lever320configured to curve housing tube200to a particular curved position. Illustratively, a geometry of one or more apertures in housing tube200may be uniform, e.g., each aperture of the one or more apertures may have a same geometry. In one or more embodiments, a geometry of one or more apertures in housing tube200may be non-uniform, e.g., a first aperture in housing tube200may have a first geometry and a second aperture in housing tube200may have a second geometry.

Illustratively, a geometry or shape of actuation lever320may be adjusted to vary an amount actuation of actuation lever320configured to curve housing tube200to a particular curved position. In one or more embodiments, one or more locations within housing tube200wherein optic fiber250may be fixed to an inner portion of housing tube200may be adjusted to vary an amount of actuation of actuation lever320configured to curve housing tube200to a particular curved position. Illustratively, at least a portion of optic fiber250may be enclosed in an optic fiber sleeve configured to, e.g., protect optic fiber250, vary a stiffness of optic fiber250, vary an optical property of optic fiber250, etc. For example, a portion of optic fiber250that may be fixed to actuation lever320, e.g., at actuation lever proximal end322, may be enclosed in an optic fiber sleeve configured to, e.g., protect optic fiber250, facilitate a fixation, etc. In one or more embodiments, a portion of optic fiber250that may be fixed to an inner portion of housing tube200may be enclosed in an optic fiber sleeve configured to, e.g., protect optic fiber250, facilitate a fixation, etc. Illustratively, a portion of housing tube200may comprise an access window, e.g., configured to allow access to an inner portion of housing tube200. In one or more embodiments, a portion of housing tube200may comprise an access window, e.g., configured to allow access to a portion of optic fiber250.

Illustratively, a stiffness of first housing tube portion220or a stiffness of second housing tube portion230may be adjusted to vary a bend radius of housing tube200. In one or more embodiments, a stiffness of first housing tube portion220or a stiffness of second housing tube portion230may be adjusted to vary a radius of curvature of housing tube200, e.g., when housing tube200is in a particular curved position. Illustratively, a number of apertures in housing tube200may be adjusted to vary a bend radius of housing tube200. In one or more embodiments, a number of apertures in housing tube200may be adjusted to vary a radius of curvature of housing tube200, e.g., when housing tube200is in a particular curved position. Illustratively, a location or a geometry of one or more apertures in housing tube200may be adjusted to vary a bend radius of housing tube200. In one or more embodiments, a location or a geometry of one or more apertures in housing tube200may be adjusted to vary a radius of curvature of housing tube200, e.g., when housing tube200is in a particular curved position.

FIGS. 5A,5B,5C,5D, and5E illustrate a gradual straightening of an optic fiber250.FIG. 5Aillustrates a fully curved optic fiber500. In one or more embodiments, optic fiber250may comprise a fully curved optic fiber500, e.g., when actuation lever proximal end322is fully retracted relative to handle base110. Illustratively, optic fiber250may comprise a fully curved optic fiber500, e.g., when first housing tube portion220is fully compressed. In one or more embodiments, a line tangent to optic fiber distal end251may be parallel to a line tangent to housing tube proximal end202, e.g., when optic fiber250comprises a fully curved optic fiber500.

FIG. 5Billustrates an optic fiber in a first partially straightened position510. Illustratively, an actuation of actuation lever320, e.g., in a counter-clockwise direction about pivot pin310, may be configured to gradually straighten optic fiber250. For example, an actuation of actuation lever320, e.g., due to a reduction of a force applied to actuation lever320, may be configured to gradually straighten optic fiber250. In one or more embodiments, a reduction of a force applied to actuation lever320may be configured to gradually straighten optic fiber250from a fully curved optic fiber500to an optic fiber in a first partially straightened position510. Illustratively, a reduction of a force applied to actuation lever320may be configured to gradually extend optic fiber250relative to housing tube200. In one or more embodiments, a gradual extension of optic fiber250relative to housing tube200may be configured to cause optic fiber250to reduce a compressive force applied to an inner portion of housing tube200. Illustratively, a reduction of a compressive force applied to an inner portion of housing tube200may be configured to decompress a first housing tube portion220of housing tube200. In one or more embodiments, a reduction of a compressive force applied to an inner portion of housing tube200may be configured to gradually straighten housing tube200. Illustratively, a gradual straightening of housing tube200may be configured to gradually straighten optic fiber250, e.g., from a fully curved optic fiber500to an optic fiber in a first partially straightened position510. In one or more embodiments, a line tangent to optic fiber distal end251may intersect a line tangent to housing tube proximal end202at a first partially straightened angle, e.g., when optic fiber250comprises an optic fiber in a first partially straightened position510. Illustratively, the first partially straightened angle may comprise any angle less than 180 degrees. For example, the first partially straightened angle may comprise a 135 degree angle.

FIG. 5Cillustrates an optic fiber in a second partially straightened position520. Illustratively, an actuation of actuation lever320, e.g., in a counter-clockwise direction about pivot pin310, may be configured to gradually straighten optic fiber250. For example, an actuation of actuation lever320, e.g., due to a reduction of a force applied to actuation lever320, may be configured to gradually straighten optic fiber250. In one or more embodiments, a reduction of a force applied to actuation lever320may be configured to gradually straighten optic fiber250from an optic fiber in a first partially straightened position510to an optic fiber in a second partially straightened position520. Illustratively, a reduction of a force applied to actuation lever320may be configured to gradually extend optic fiber250relative to housing tube200. In one or more embodiments, a gradual extension of optic fiber250relative to housing tube200may be configured to cause optic fiber250to reduce a compressive force applied to an inner portion of housing tube200. Illustratively, a reduction of a compressive force applied to an inner portion of housing tube200may be configured to decompress a first housing tube portion220of housing tube200. In one or more embodiments, a reduction of a compressive force applied to an inner portion of housing tube200may be configured to gradually straighten housing tube200. Illustratively, a gradual straightening of housing tube200may be configured to gradually straighten optic fiber250, e.g., from an optic fiber in a first partially straightened position510to an optic fiber in a second partially straightened position520. In one or more embodiments, a line tangent to optic fiber distal end251may intersect a line tangent to housing tube proximal end202at a second partially straightened angle, e.g., when optic fiber250comprises an optic fiber in a second partially straightened position520. Illustratively, the second partially straightened angle may comprise any angle less than the first partially straightened angle. For example, the second partially straightened angle may comprise a 90 degree angle.

FIG. 5Dillustrates an optic fiber in a third partially straightened position530. Illustratively, an actuation of actuation lever320, e.g., in a counter-clockwise direction about pivot pin310, may be configured to gradually straighten optic fiber250. For example, an actuation of actuation lever320, e.g., due to a reduction of a force applied to actuation lever320, may be configured to gradually straighten optic fiber250. In one or more embodiments, a reduction of a force applied to actuation lever320may be configured to gradually straighten optic fiber250from an optic fiber in a second partially straightened position520to an optic fiber in a third partially straightened position530. Illustratively, a reduction of a force applied to actuation lever320may be configured to gradually extend optic fiber250relative to housing tube200. In one or more embodiments, a gradual extension of optic fiber250relative to housing tube200may be configured to cause optic fiber250to reduce a compressive force applied to an inner portion of housing tube200. Illustratively, a reduction of a compressive force applied to an inner portion of housing tube200may be configured to decompress a first housing tube portion220of housing tube200. In one or more embodiments, a reduction of a compressive force applied to an inner portion of housing tube200may be configured to gradually straighten housing tube200. Illustratively, a gradual straightening of housing tube200may be configured to gradually straighten optic fiber250, e.g., from an optic fiber in a second partially straightened position520to an optic fiber in a third partially straightened position530. In one or more embodiments, a line tangent to optic fiber distal end251may intersect a line tangent to housing tube proximal end202at a third partially straightened angle, e.g., when optic fiber250comprises an optic fiber in a third partially straightened position530. Illustratively, the third partially straightened angle may comprise any angle less than the second partially straightened angle. For example, the third partially straightened angle may comprise a 45 degree angle.

FIG. 5Eillustrates an optic fiber in a fully straightened position540. Illustratively, an actuation of actuation lever320, e.g., in a counter-clockwise direction about pivot pin310, may be configured to gradually straighten optic fiber250. For example, an actuation of actuation lever320, e.g., due to a reduction of a force applied to actuation lever320, may be configured to gradually straighten optic fiber250. In one or more embodiments, a reduction of a force applied to actuation lever320may be configured to gradually straighten optic fiber250from an optic fiber in a third partially straightened position530to an optic fiber in a fully straightened position540. Illustratively, a reduction of a force applied to actuation lever320may be configured to gradually extend optic fiber250relative to housing tube200. In one or more embodiments, a gradual extension of optic fiber250relative to housing tube200may be configured to cause optic fiber250to reduce a compressive force applied to an inner portion of housing tube200. Illustratively, a reduction of a compressive force applied to an inner portion of housing tube200may be configured to decompress a first housing tube portion220of housing tube200. In one or more embodiments, a reduction of a compressive force applied to an inner portion of housing tube200may be configured to gradually straighten housing tube200. Illustratively, a gradual straightening of housing tube200may be configured to gradually straighten optic fiber250, e.g., from an optic fiber in a third partially straightened position530to an optic fiber in a fully straightened position540. In one or more embodiments, a line tangent to optic fiber distal end251may be parallel to a line tangent to housing tube proximal end202, e.g., when optic fiber250comprises an optic fiber in a fully straightened position540.

Illustratively, a surgeon may aim optic fiber distal end251at any of a plurality of targets within an eye, e.g., to perform a photocoagulation procedure. In one or more embodiments, a surgeon may aim optic fiber distal end251at any target within a particular transverse plane of the inner eye by, e.g., rotating handle100to orient housing tube200in an orientation configured to cause a curvature of housing tube200within the particular transverse plane of the inner eye and varying an amount of actuation of actuation lever320. Illustratively, a surgeon may aim optic fiber distal end251at any target within a particular sagittal plane of the inner eye by, e.g., rotating handle100to orient housing tube200in an orientation configured to cause a curvature of housing tube200within the particular sagittal plane of the inner eye and varying an amount of actuation of actuation lever320. In one or more embodiments, a surgeon may aim optic fiber distal end251at any target within a particular frontal plane of the inner eye by, e.g., varying an amount of actuation of actuation lever320to orient a line tangent to optic fiber distal end251wherein the line tangent to optic fiber distal end251is within the particular frontal plane of the inner eye and rotating handle100. Illustratively, a surgeon may aim optic fiber distal end251at any target located outside of the particular transverse plane, the particular sagittal plane, and the particular frontal plane of the inner eye, e.g., by varying a rotational orientation of handle100and varying an amount of actuation of actuation lever320. In one or more embodiments, a surgeon may aim optic fiber distal end251at any target of a plurality of targets within an eye, e.g., without increasing a length of a portion of a steerable laser probe within the eye. Illustratively, a surgeon may aim optic fiber distal end251at any target of a plurality of targets within an eye, e.g., without decreasing a length of a portion of a steerable laser probe within the eye.

FIGS. 6A and 6Bare schematic diagrams illustrating a handle600.FIG. 6Aillustrates a top view of handle600. Illustratively, handle600may comprise a handle distal end601and a handle proximal end602. In one or more embodiments, handle600may comprise a handle base610, an actuation channel620having an actuation channel distal end621and an actuation channel proximal end622, and a pivot pin housing630.FIG. 6Billustrates a cross-sectional view of handle600. Illustratively, handle600may comprise an inner bore640, an inner bore distal chamber650, and an optic fiber guide660. Handle600may be manufactured from any suitable material, e.g., polymers, metals, metal alloys, etc., or from any combination of suitable materials.

FIGS. 7A,7B, and7C are schematic diagrams illustrating a housing tube700. In one or more embodiments, housing tube700may comprise a housing tube distal end701and a housing tube proximal end702. Housing tube700may be manufactured from any suitable material, e.g., polymers, metals, metal alloys, etc., or from any combination of suitable materials.FIG. 7Aillustrates a housing tube700oriented to illustrate a first housing tube portion720. Illustratively, first housing tube portion720may have a first stiffness.FIG. 7Billustrates a housing tube700oriented to illustrate a second housing tube portion730. Illustratively, second housing tube portion730may have a second stiffness. In one or more embodiments, the second stiffness may be greater than the first stiffness. Illustratively, first housing tube portion720may comprise a first material having a first stiffness. In one or more embodiments, second housing tube portion730may comprise a second material having a second stiffness. Illustratively, the second stiffness may be greater than the first stiffness.

In one or more embodiments, first housing tube portion720may comprise one or more apertures configured to produce a first stiffness of first housing tube portion720. Illustratively, second housing tube portion730may comprise a solid portion of housing tube700having a second stiffness. In one or more embodiments, the second stiffness may be greater than the first stiffness. Illustratively, first housing tube portion720may comprise one or more apertures configured to produce a first stiffness of first housing tube portion720. In one or more embodiments, second housing tube portion730may comprise one or more apertures configured to produce a second stiffness of second housing tube portion730. Illustratively, the second stiffness may be greater than the first stiffness.

In one or more embodiments, first housing tube portion720may comprise a plurality of slits configured to separate one or more solid portions of housing tube700. Illustratively, a plurality of slits may be cut, e.g., laser cut, into first housing tube portion720. In one or more embodiments, first housing tube portion720may comprise a plurality of slits configured to minimize a force of friction between housing tube700and a cannula, e.g., as housing tube700is inserted into the cannula or as housing tube700is extracted from the cannula. For example, each slit of the plurality of slits may comprise one or more arches configured to minimize a force of friction between housing tube700and a cannula.

FIG. 7Cillustrates an angled view of housing tube700. Illustratively, an optic fiber750may be disposed within housing tube700. In one or more embodiments, optic fiber750may be disposed within housing tube700wherein an optic fiber distal end751is adjacent to housing tube distal end701. Illustratively, optic fiber750may be disposed within housing tube700wherein a portion of optic fiber750may be adjacent to a portion of first housing tube portion720. In one or more embodiments, a portion of optic fiber750may be fixed to an inner portion of housing tube700, e.g., by a biocompatible adhesive or any other suitable means.

Illustratively, a wire740may be disposed within housing tube700. In one or more embodiments, wire740may be disposed within housing tube700wherein a wire distal end741may be adjacent to housing tube distal end701. Illustratively, wire740may be disposed within housing tube700wherein a portion of wire740may be adjacent to a portion of first housing tube portion720. In one or more embodiments, a portion of wire740may be fixed to an inner portion of housing tube700, e.g., by a biocompatible adhesive or any other suitable fixation means.

FIG. 8is a schematic diagram illustrating an exploded view of a steerable laser probe assembly800. In one or more embodiments, a steerable laser probe assembly800may comprise a handle600, a housing tube700having a housing tube distal end701and a housing tube proximal end702, a wire740having a wire distal end741and a wire proximal loop742, an optic fiber750having an optic fiber distal end751and an optic fiber proximal end752, a pivot pin810, an actuation lever820having an actuation lever distal end821and an actuation lever proximal end822, and a light source interface830. Illustratively, light source interface830may be configured to interface with optic fiber proximal end752. In one or more embodiments, light source interface830may comprise a standard light source connector, e.g., an SMA connector.

Illustratively, actuation lever820may comprise a pivot pin guide825. In one or more embodiments, pivot pin810may be disposed within pivot pin housing630and pivot pin guide825. Illustratively, pivot pin810may be configured to fix a portion of actuation lever820to a portion of handle600. In one or more embodiments, pivot pin810may be fixed in a position within pivot pin housing630. For example, pivot pin810may be fixed in a position within pivot pin housing630, e.g., by an adhesive or any other suitable fixation means.

Illustratively, housing tube700may be fixed to handle600, e.g., housing tube proximal end702may be fixed to handle distal end601. In one or more embodiments, housing tube700may be fixed to handle600, e.g., by an adhesive or any suitable fixation means. Illustratively, actuation lever820may comprise a wire proximal loop housing826. In one or more embodiments, wire proximal loop742may be disposed within wire proximal loop housing826. Illustratively, wire proximal loop742may be fixed within wire proximal loop housing826, e.g., by an adhesive or any suitable fixation means. In one or more embodiments, a portion of actuation lever820may be disposed within wire proximal loop742, e.g., wire proximal loop742may be looped around a portion of actuation lever820. Illustratively, wire740may be disposed within actuation channel620, inner bore distal chamber650, optic fiber guide660, and housing tube700. In one or more embodiments, wire740may be disposed within housing tube700wherein wire distal end741may be adjacent to housing tube distal end701. Illustratively, wire740may be disposed within housing tube700wherein a portion of wire740may be adjacent to a portion of first housing tube portion720. In one or more embodiments, a portion of wire740may be fixed to an inner portion of housing tube700, e.g., by a biocompatible adhesive or by any other suitable fixation means.

Illustratively, optic fiber750may be disposed within inner bore640, actuation channel620, inner bore distal chamber650, optic fiber guide660, and housing tube700. In one or more embodiments, optic fiber750may be disposed within housing tube700wherein optic fiber distal end751may be adjacent to housing tube distal end701. Illustratively, a portion of optic fiber750may be fixed to an inner portion of housing tube700, e.g., by a biocompatible adhesive or by any other suitable fixation means.

In one or more embodiments, an application of a force to actuation lever820may be configured to actuate actuation lever820, e.g., within actuation channel620. Illustratively, an application of a force to actuation lever820may be configured to rotate actuation lever820about pivot pin810. In one or more embodiments, an application of a force to actuation lever820may be configured to rotate actuation lever distal end821and actuation lever proximal end822about pivot pin810, e.g., in a clockwise direction. Illustratively, an application of a force to actuation lever820may be configured to actuate actuation lever distal end821away from handle proximal end602and configured to actuate actuation lever proximal end822towards handle proximal end602. For example, an application of a force to actuation lever820may be configured to retract actuation lever proximal end822relative to handle base610.

Illustratively, an actuation of actuation lever proximal end822towards handle proximal end602, e.g., due to an application of a force to actuation lever820, may be configured to retract wire740relative to housing tube700. In one or more embodiments, a retraction of wire740relative to housing tube700may be configured to cause wire740to apply a compressive force to an inner portion of housing tube700. Illustratively, an application of a compressive force to an inner portion of housing tube700may be configured to gradually compress a portion of housing tube700, e.g., a first housing tube portion720of housing tube700. In one or more embodiments, a gradual compression of a portion of housing tube700may be configured to cause housing tube700to gradually curve. Illustratively, a gradual curving of housing tube700may be configured to gradually curve optic fiber750.

In one or more embodiments, a reduction of a force applied to actuation lever820may be configured to actuate actuation lever820, e.g., within actuation channel620. Illustratively, a reduction of a force applied to actuation lever820may be configured to rotate actuation lever820about pivot pin810. In one or more embodiments, a reduction of a force applied to actuation lever820may be configured to rotate actuation lever distal end821and actuation lever proximal end822about pivot pin810, e.g., in a counter-clockwise direction. Illustratively, a reduction of a force applied to actuation lever820may be configured to actuate actuation lever distal end821towards handle proximal end602and configured to actuate actuation lever proximal end822away from handle proximal end602. For example, a reduction of a force applied to actuation lever820may be configured to extend actuation lever proximal end822relative to handle base610.

In one or more embodiments, an actuation of actuation lever proximal end822away from handle proximal end602, e.g., due to a reduction of a force applied to actuation lever820, may be configured to extend wire740relative to housing tube700. Illustratively, an extension of wire740relative to housing tube700may be configured to cause wire740to reduce a compressive force applied to an inner portion of housing tube700. In one or more embodiments, a reduction of a compressive force applied to an inner portion of housing tube700may be configured to gradually decompress a portion of housing tube700, e.g., a first housing tube portion720of housing tube700. Illustratively, a gradual decompression of a portion of housing tube700may be configured to cause housing tube700to gradually straighten. In one or more embodiments, a gradual straightening of housing tube700may be configured to gradually straighten optic fiber750.

FIGS. 9A,9B,9C,9D, and9E illustrate a gradual curving of an optic fiber750.FIG. 9Aillustrates a straight optic fiber900. In one or more embodiments, optic fiber750may comprise a straight optic fiber900, e.g., when actuation lever proximal end822is fully extended relative to handle base610. Illustratively, optic fiber750may comprise a straight optic fiber900, e.g., when first housing tube portion720is fully decompressed. In one or more embodiments, a line tangent to optic fiber distal end751may be parallel to a line tangent to housing tube proximal end702, e.g., when optic fiber750comprises a straight optic fiber900.

FIG. 9Billustrates an optic fiber in a first curved position910. Illustratively, an actuation of actuation lever820, e.g., in a clockwise direction about pivot pin810, may be configured to gradually curve optic fiber750. For example, an actuation of actuation lever820, e.g., due to an application of a force to actuation lever820, may be configured to gradually curve optic fiber750. In one or more embodiments, an application of a force to actuation lever820may be configured to gradually curve optic fiber750from a straight optic fiber900to an optic fiber in a first curved position910. Illustratively, an application of a force to actuation lever820may be configured to gradually retract wire740relative to housing tube700. In one or more embodiments, a gradual retraction of wire740relative to housing tube700may be configured to cause wire740to apply a compressive force to an inner portion of housing tube700. Illustratively, an application of a compressive force to an inner portion of housing tube700may be configured to compress a first housing tube portion720of housing tube700. In one or more embodiments, an application of a compressive force to an inner portion of housing tube700may be configured to gradually curve housing tube700. Illustratively, a gradual curving of housing tube700may be configured to gradually curve optic fiber750, e.g., from a straight optic fiber900to an optic fiber in a first curved position910. In one or more embodiments, a line tangent to optic fiber distal end751may intersect a line tangent to housing tube proximal end702at a first angle, e.g., when optic fiber750comprises an optic fiber in a first curved position910. Illustratively, the first angle may comprise any angle greater than zero degrees. For example, the first angle may comprise a 45 degree angle.

FIG. 9Cillustrates an optic fiber in a second curved position920. Illustratively, an actuation of actuation lever820, e.g., in a clockwise direction about pivot pin810, may be configured to gradually curve optic fiber750. For example, an actuation of actuation lever820, e.g., due to an application of a force to actuation lever820, may be configured to gradually curve optic fiber750. In one or more embodiments, an application of a force to actuation lever820may be configured to gradually curve optic fiber750from an optic fiber in a first curved position910to an optic fiber in a second curved position920. Illustratively, an application of a force to actuation lever820may be configured to gradually retract wire740relative to housing tube700. In one or more embodiments, a gradual retraction of wire740relative to housing tube700may be configured to cause wire740to apply a compressive force to an inner portion of housing tube700. Illustratively, an application of a compressive force to an inner portion of housing tube700may be configured to compress a first housing tube portion720of housing tube700. In one or more embodiments, an application of a compressive force to an inner portion of housing tube700may be configured to gradually curve housing tube700. Illustratively, a gradual curving of housing tube700may be configured to gradually curve optic fiber750, e.g., from an optic fiber in a first curved position910to an optic fiber in a second curved position920. In one or more embodiments, a line tangent to optic fiber distal end751may intersect a line tangent to housing tube proximal end702at a second angle, e.g., when optic fiber750comprises an optic fiber in a second curved position920. Illustratively, the second angle may comprise any angle greater than the first angle. For example, the second angle may comprise a 90 degree angle.

FIG. 9Dillustrates an optic fiber in a third curved position930. Illustratively, an actuation of actuation lever820, e.g., in a clockwise direction about pivot pin810, may be configured to gradually curve optic fiber750. For example, an actuation of actuation lever820, e.g., due to an application of a force to actuation lever820, may be configured to gradually curve optic fiber750. In one or more embodiments, an application of a force to actuation lever820may be configured to gradually curve optic fiber750from an optic fiber in a second curved position920to an optic fiber in a third curved position930. Illustratively, an application of a force to actuation lever820may be configured to gradually retract wire740relative to housing tube700. In one or more embodiments, a gradual refraction of wire740relative to housing tube700may be configured to cause wire740to apply a compressive force to an inner portion of housing tube700. Illustratively, an application of a compressive force to an inner portion of housing tube700may be configured to compress a first housing tube portion720of housing tube700. In one or more embodiments, an application of a compressive force to an inner portion of housing tube700may be configured to gradually curve housing tube700. Illustratively, a gradual curving of housing tube700may be configured to gradually curve optic fiber750, e.g., from an optic fiber in a second curved position920to an optic fiber in a third curved position930. In one or more embodiments, a line tangent to optic fiber distal end751may intersect a line tangent to housing tube proximal end702at a third angle, e.g., when optic fiber750comprises an optic fiber in a third curved position930. Illustratively, the third angle may comprise any angle greater than the second angle. For example, the third angle may comprise a 135 degree angle.

FIG. 9Eillustrates an optic fiber in a fourth curved position940. Illustratively, an actuation of actuation lever820, e.g., in a clockwise direction about pivot pin810, may be configured to gradually curve optic fiber750. For example, an actuation of actuation lever820, e.g., due to an application of a force to actuation lever820, may be configured to gradually curve optic fiber750. In one or more embodiments, an application of a force to actuation lever820may be configured to gradually curve optic fiber750from an optic fiber in a third curved position930to an optic fiber in a forth curved position940. Illustratively, an application of a force to actuation lever820may be configured to gradually retract wire740relative to housing tube700. In one or more embodiments, a gradual retraction of wire740relative to housing tube700may be configured to cause wire740to apply a compressive force to an inner portion of housing tube700. Illustratively, an application of a compressive force to an inner portion of housing tube700may be configured to compress a first housing tube portion720of housing tube700. In one or more embodiments, an application of a compressive force to an inner portion of housing tube700may be configured to gradually curve housing tube700. Illustratively, a gradual curving of housing tube700may be configured to gradually curve optic fiber750, e.g., from an optic fiber in a third curved position930to an optic fiber in a fourth curved position940. For example, a line tangent to optic fiber distal end751may be parallel to a line tangent to housing tube proximal end702, e.g., when optic fiber750comprises an optic fiber in a fourth curved position940.

In one or more embodiments, one or more properties of a steerable laser probe may be adjusted to attain one or more desired steerable laser probe features. For example, a stiffness of first housing tube portion720or a stiffness of second housing tube portion730may be adjusted to vary an amount of actuation of actuation lever820configured to curve housing tube700to a particular curved position. Illustratively, a material comprising first housing tube portion720or a material comprising second housing tube portion730may be adjusted to vary an amount of actuation of actuation lever820configured to curve housing tube700to a particular curved position.

In one or more embodiments, a number of apertures in housing tube700may be adjusted to vary an amount of actuation of actuation lever820configured to curve housing tube700to a particular curved position. Illustratively, a location of one or more apertures in housing tube700may be adjusted to vary an amount of actuation of actuation lever820configured to curve housing tube700to a particular curved position. In one or more embodiments, a geometry of one or more apertures in housing tube700may be adjusted to vary an amount of actuation of actuation lever820configured to curve housing tube700to a particular curved position. Illustratively, a geometry of one or more apertures in housing tube700may be uniform, e.g., each aperture of the one or more apertures may have a same geometry. In one or more embodiments, a geometry of one or more apertures in housing tube700may be non-uniform, e.g., a first aperture in housing tube700may have a first geometry and a second aperture in housing tube700may have a second geometry.

Illustratively, a geometry or shape of actuation lever820may be adjusted to vary an amount actuation of actuation lever820configured to curve housing tube700to a particular curved position. In one or more embodiments, one or more locations within housing tube700wherein wire740may be fixed to an inner portion of housing tube700may be adjusted to vary an amount of actuation of actuation lever820configured to curve housing tube700to a particular curved position. Illustratively, a portion of wire740may be fixed to an outer portion of housing tube700. In one or more embodiments, a portion of wire740may be looped around a portion of housing tube700. For example, wire proximal loop742may be adjusted to comprise a straight portion of wire740. Illustratively, a portion of housing tube700may comprise an access window, e.g., configured to allow access to an inner portion of housing tube700. In one or more embodiments, a portion of housing tube700may comprise an access window, e.g., configured to allow access to a portion of optic fiber750or a portion of wire740. Illustratively, at least a portion of optic fiber750may be enclosed in an optic fiber sleeve configured to, e.g., protect optic fiber750, vary a stiffness of optic fiber750, vary an optical property of optic fiber750, etc.

In one or more embodiments, a stiffness of first housing tube portion720or a stiffness of second housing tube portion730may be adjusted to vary a bend radius of housing tube700. Illustratively, a stiffness of first housing tube portion720or a stiffness of second housing tube portion730may be adjusted to vary a radius of curvature of housing tube700, e.g., when housing tube700is in a particular curved position. In one or more embodiments, a number of apertures in housing tube700may be adjusted to vary a bend radius of housing tube700. Illustratively, a number of apertures in housing tube700may be adjusted to vary a radius of curvature of housing tube700, e.g., when housing tube700is in a particular curved position. In one or more embodiments, a location or a geometry of one or more apertures in housing tube700may be adjusted to vary a bend radius of housing tube700. Illustratively, a location or a geometry of one or more apertures in housing tube700may be adjusted to vary a radius of curvature of housing tube700, e.g., when housing tube700is in a particular curved position.

FIGS. 10A,10B,10C,10D, and10E illustrate a gradual straightening of an optic fiber750.FIG. 10Aillustrates a fully curved optic fiber1000. In one or more embodiments, optic fiber750may comprise a fully curved optic fiber1000, e.g., when actuation lever proximal end822is fully retracted relative to handle base610. Illustratively, optic fiber750may comprise a fully curved optic fiber1000, e.g., when first housing tube portion720is fully compressed. In one or more embodiments, a line tangent to optic fiber distal end751may be parallel to a line tangent to housing tube proximal end702, e.g., when optic fiber750comprises a fully curved optic fiber1000.

FIG. 10Billustrates an optic fiber in a first partially straightened position1010. Illustratively, an actuation of actuation lever820, e.g., in a counter-clockwise direction about pivot pin810, may be configured to gradually straighten optic fiber750. For example, an actuation of actuation lever820, e.g., due to a reduction of a force applied to actuation lever820, may be configured to gradually straighten optic fiber750. In one or more embodiments, a reduction of a force applied to actuation lever820may be configured to gradually straighten optic fiber750from a fully curved optic fiber1000to an optic fiber in a first partially straightened position1010. Illustratively, a reduction of a force applied to actuation lever820may be configured to gradually extend wire740relative to housing tube700. In one or more embodiments, a gradual extension of wire740relative to housing tube700may be configured to cause wire740to reduce a compressive force applied to an inner portion of housing tube700. Illustratively, a reduction of a compressive force applied to an inner portion of housing tube700may be configured to decompress a first housing tube portion720of housing tube700. In one or more embodiments, a reduction of a compressive force applied to an inner portion of housing tube700may be configured to gradually straighten housing tube700. Illustratively, a gradual straightening of housing tube700may be configured to gradually straighten optic fiber750, e.g., from a fully curved optic fiber1000to an optic fiber in a first partially straightened position1010. In one or more embodiments, a line tangent to optic fiber distal end751may intersect a line tangent to housing tube proximal end702at a first partially straightened angle, e.g., when optic fiber750comprises an optic fiber in a first partially straightened position1010. Illustratively, the first partially straightened angle may comprise any angle less than 180 degrees. For example, the first partially straightened angle may comprise a 135 degree angle.

FIG. 10Cillustrates an optic fiber in a second partially straightened position1020. Illustratively, an actuation of actuation lever820, e.g., in a counter-clockwise direction about pivot pin810, may be configured to gradually straighten optic fiber750. For example, an actuation of actuation lever820, e.g., due to a reduction of a force applied to actuation lever820, may be configured to gradually straighten optic fiber750. In one or more embodiments, a reduction of a force applied to actuation lever820may be configured to gradually straighten optic fiber750from an optic fiber in a first partially straightened position1010to an optic fiber in a second partially straightened position1020. Illustratively, a reduction of a force applied to actuation lever820may be configured to gradually extend wire740relative to housing tube700. In one or more embodiments, a gradual extension of wire740relative to housing tube700may be configured to cause wire740to reduce a compressive force applied to an inner portion of housing tube700. Illustratively, a reduction of a compressive force applied to an inner portion of housing tube700may be configured to decompress a first housing tube portion720of housing tube700. In one or more embodiments, a reduction of a compressive force applied to an inner portion of housing tube700may be configured to gradually straighten housing tube700. Illustratively, a gradual straightening of housing tube700may be configured to gradually straighten optic fiber750, e.g., from an optic fiber in a first partially straightened position1010to an optic fiber in a second partially straightened position1020. In one or more embodiments, a line tangent to optic fiber distal end751may intersect a line tangent to housing tube proximal end702at a second partially straightened angle, e.g., when optic fiber750comprises an optic fiber in a second partially straightened position1020. Illustratively, the second partially straightened angle may comprise any angle less than the first partially straightened angle. For example, the second partially straightened angle may comprise a 90 degree angle.

FIG. 10Dillustrates an optic fiber in a third partially straightened position1030. Illustratively, an actuation of actuation lever820, e.g., in a counter-clockwise direction about pivot pin810, may be configured to gradually straighten optic fiber750. For example, an actuation of actuation lever820, e.g., due to a reduction of a force applied to actuation lever820, may be configured to gradually straighten optic fiber750. In one or more embodiments, a reduction of a force applied to actuation lever820may be configured to gradually straighten optic fiber750from an optic fiber in a second partially straightened position1020to an optic fiber in a third partially straightened position1030. Illustratively, a reduction of a force applied to actuation lever820may be configured to gradually extend wire740relative to housing tube700. In one or more embodiments, a gradual extension of wire740relative to housing tube700may be configured to cause wire740to reduce a compressive force applied to an inner portion of housing tube700. Illustratively, a reduction of a compressive force applied to an inner portion of housing tube700may be configured to decompress a first housing tube portion720of housing tube700. In one or more embodiments, a reduction of a compressive force applied to an inner portion of housing tube700may be configured to gradually straighten housing tube700. Illustratively, a gradual straightening of housing tube700may be configured to gradually straighten optic fiber750, e.g., from an optic fiber in a second partially straightened position1020to an optic fiber in a third partially straightened position1030. In one or more embodiments, a line tangent to optic fiber distal end751may intersect a line tangent to housing tube proximal end702at a third partially straightened angle, e.g., when optic fiber750comprises an optic fiber in a third partially straightened position1030. Illustratively, the third partially straightened angle may comprise any angle less than the second partially straightened angle. For example, the third partially straightened angle may comprise a 45 degree angle.

FIG. 10Eillustrates an optic fiber in a fully straightened position1040. Illustratively, an actuation of actuation lever820, e.g., in a counter-clockwise direction about pivot pin810, may be configured to gradually straighten optic fiber750. For example, an actuation of actuation lever820, e.g., due to a reduction of a force applied to actuation lever820, may be configured to gradually straighten optic fiber750. In one or more embodiments, a reduction of a force applied to actuation lever820may be configured to gradually straighten optic fiber750from an optic fiber in a third partially straightened position1030to an optic fiber in a fully straightened position1040. Illustratively, a reduction of a force applied to actuation lever820may be configured to gradually extend wire740relative to housing tube700. In one or more embodiments, a gradual extension of wire740relative to housing tube700may be configured to cause wire740to reduce a compressive force applied to an inner portion of housing tube700. Illustratively, a reduction of a compressive force applied to an inner portion of housing tube700may be configured to decompress a first housing tube portion720of housing tube700. In one or more embodiments, a reduction of a compressive force applied to an inner portion of housing tube700may be configured to gradually straighten housing tube700. Illustratively, a gradual straightening of housing tube700may be configured to gradually straighten optic fiber750, e.g., from an optic fiber in a third partially straightened position1030to an optic fiber in a fully straightened position1040. In one or more embodiments, a line tangent to optic fiber distal end751may be parallel to a line tangent to housing tube proximal end702, e.g., when optic fiber750comprises an optic fiber in a fully straightened position1040.

Illustratively, a surgeon may aim optic fiber distal end751at any of a plurality of targets within an eye, e.g., to perform a photocoagulation procedure. In one or more embodiments, a surgeon may aim optic fiber distal end751at any target within a particular transverse plane of the inner eye by, e.g., rotating handle600to orient housing tube700in an orientation configured to cause a curvature of housing tube700within the particular transverse plane of the inner eye and varying an amount of actuation of actuation lever820. Illustratively, a surgeon may aim optic fiber distal end751at any target within a particular sagittal plane of the inner eye by, e.g., rotating handle600to orient housing tube700in an orientation configured to cause a curvature of housing tube700within the particular sagittal plane of the inner eye and varying an amount of actuation of actuation lever820. In one or more embodiments, a surgeon may aim optic fiber distal end751at any target within a particular frontal plane of the inner eye by, e.g., varying an amount of actuation of actuation lever820to orient a line tangent to optic fiber distal end751wherein the line tangent to optic fiber distal end751is within the particular frontal plane of the inner eye and rotating handle600. Illustratively, a surgeon may aim optic fiber distal end751at any target located outside of the particular transverse plane, the particular sagittal plane, and the particular frontal plane of the inner eye, e.g., by varying a rotational orientation of handle600and varying an amount of actuation of actuation lever820. In one or more embodiments, a surgeon may aim optic fiber distal end751at any target of a plurality of targets within an eye, e.g., without increasing a length of a portion of a steerable laser probe within the eye. Illustratively, a surgeon may aim optic fiber distal end751at any target of a plurality of targets within an eye, e.g., without decreasing a length of a portion of a steerable laser probe within the eye.

FIGS. 11A and 11Bare schematic diagrams illustrating a handle1100.FIG. 11Aillustrates a top view of handle1100. Illustratively, handle1100may comprise a handle distal end1101and a handle proximal end1102. In one or more embodiments, handle1100may comprise a handle base1110, an actuation channel1120having an actuation channel distal end1121and an actuation channel proximal end1122, and a pivot pin housing1130.FIG. 11Billustrates a cross-sectional view of handle1100. Illustratively, handle1100may comprise a pulley mechanism housing1135, an inner bore1140, an inner bore distal chamber1150, and an optic fiber guide1160. Handle1100may be manufactured from any suitable material, e.g., polymers, metals, metal alloys, etc., or from any combination of suitable materials.

FIG. 12is a schematic diagram illustrating an exploded view of a steerable laser probe assembly1200. In one or more embodiments, a steerable laser probe assembly1200may comprise a handle1100, a housing tube700having a housing tube distal end701and a housing tube proximal end702, an optic fiber750having an optic fiber distal end751and an optic fiber proximal end752, a pulley mechanism1205, a pivot pin1210, an actuation lever1220having an actuation lever distal end1221and an actuation lever proximal end1222, a draw wire1240having a draw wire distal end1241and a draw wire proximal end1242, and a light source interface830. Illustratively, light source interface830may be configured to interface with optic fiber proximal end752. In one or more embodiments, light source interface830may comprise a standard light source connector, e.g., an SMA connector.

Illustratively, actuation lever1220may comprise a pivot pin guide1225. In one or more embodiments, pivot pin1210may be disposed within pivot pin housing1130and pivot pin guide1225. Illustratively, pivot pin1210may be configured to fix a portion of actuation lever1220to a portion of handle1100. In one or more embodiments, pivot pin1210may be fixed in a position within pivot pin housing1130. For example, pivot pin1210may be fixed in a position within pivot pin housing1130, e.g., by an adhesive or any other suitable fixation means.

Illustratively, housing tube700may be fixed to handle1100, e.g., housing tube proximal end702may be fixed to handle distal end1101. In one or more embodiments, housing tube700may be fixed to handle1100, e.g., by an adhesive or any suitable fixation means. Illustratively, housing tube700may comprise a first housing tube portion720having a first stiffness and a second housing tube portion730having a second stiffness. In one or more embodiments, the second stiffness may be greater than the first stiffness.

Illustratively, pulley mechanism1205may be disposed within pulley mechanism housing1135. In one or more embodiments, pulley mechanism1205may be configured to change a direction of an applied force, e.g., a force applied to draw wire1240. For example, pulley mechanism1205may comprise any suitable mechanism configured to change a direction of an applied force. Illustratively, pulley mechanism1205may be configured to change a point of application of an applied force, e.g., by changing a direction of an applied force. For example, pulley mechanism1205may be configured to change a direction and a point of application of an applied force, e.g., a force applied to draw wire1240. In one or more embodiments, pulley mechanism1205may comprise a rod configured to change a direction of an applied force, e.g., a force applied to draw wire1240. For example, pulley mechanism1205may comprise a rod configured to change a point of application of an applied force, e.g., a force applied to draw wire1240. Illustratively, pulley mechanism1205may comprise one or more channels configured to, e.g., interface with a portion of draw wire1240. In one or more embodiments, a portion of pulley mechanism1205may be coated with a lubricant, e.g., Teflon, configured to minimize a force of friction between pulley mechanism1205and draw wire1240. Illustratively, pulley mechanism1205may be configured to rotate, e.g., to change a direction of an applied force, or a portion of pulley mechanism1205, e.g., a wheel, may be configured to rotate, e.g., to change a direction of an applied force. For example, pulley mechanism1205or a portion of pulley mechanism1205may be configured to change a point of application of an applied force, e.g., a force applied to draw wire1240. In one or more embodiments, pulley mechanism1205may be configured to remain in static equilibrium, e.g., not to rotate, to change a direction of an applied force, e.g., a force applied to draw wire1240. For example, a change in a direction of an applied force may be configured to change one or more points of application of the applied force. Illustratively, a portion of pulley mechanism1205may be configured to house a portion of optic fiber750.

In one or more embodiments, draw wire proximal end1242may be fixed to actuation lever proximal end1222. Illustratively, draw wire proximal end1242may be fixed to actuation lever proximal end1222, e.g., by an adhesive or any other suitable fixation means. Illustratively, actuation lever1220may comprise a draw wire proximal end housing1226. In one or more embodiments, draw wire proximal end1242may be fixed within draw wire proximal end housing1226, e.g., by an adhesive or any suitable fixation means.

Illustratively, a portion of draw wire1240may comprise a draw wire loop1245. In one or more embodiments, pulley mechanism1205may be disposed within draw wire loop1245. For example, draw wire loop1245may be looped around pulley mechanism1205. Illustratively, draw wire1240may be disposed within inner bore1140, actuation channel1120, inner bore distal chamber1150, optic fiber guide1160, and housing tube700. In one or more embodiments, draw wire1240may be disposed within housing tube700wherein draw wire distal end1241may be adjacent to housing tube distal end701. Illustratively, draw wire1240may be disposed within housing tube700wherein a portion of draw wire1240may be adjacent to a portion of first housing tube portion720. In one or more embodiments, a portion of draw wire1240may be fixed to an inner portion of housing tube700, e.g., by a biocompatible adhesive or by any other suitable fixation means.

Illustratively, optic fiber750may be disposed within inner bore1140, actuation channel1120, inner bore distal chamber1150, optic fiber guide1160, and housing tube700. In one or more embodiments, optic fiber750may be disposed within housing tube700wherein optic fiber distal end751may be adjacent to housing tube distal end701. Illustratively, a portion of optic fiber750may be fixed to an inner portion of housing tube700, e.g., by a biocompatible adhesive or by any other suitable fixation means.

In one or more embodiments, an application of a force to actuation lever1220may be configured to actuate actuation lever1220, e.g., within actuation channel1120. Illustratively, an application of a force to actuation lever1220may be configured to rotate actuation lever1220about pivot pin1210. In one or more embodiments, an application of a force to actuation lever1220may be configured to rotate actuation lever distal end1221and actuation lever proximal end1222about pivot pin1210, e.g., in a counter-clockwise direction. Illustratively, an application of a force to actuation lever1220may be configured to actuate actuation lever distal end1221towards handle proximal end1102and configured to actuate actuation lever proximal end1222away from handle proximal end1102. For example, an application of a force to actuation lever1220may be configured to extend actuation lever proximal end1222relative to handle base1110. In one or more embodiments, an application of a force to actuation lever1220may be configured to extend draw wire proximal end1242relative to handle proximal end1102.

Illustratively, an actuation of actuation lever proximal end1222away from handle proximal end1102, e.g., due to an application of a force to actuation lever1220, may be configured to extend draw wire proximal end1242relative to handle proximal end1102. For example, an actuation of actuation lever proximal end1222away from handle proximal end1102may be configured to pull draw wire proximal end1242away from handle proximal end1102. In one or more embodiments, pulley mechanism1205may be configured to change a direction and a point of application of a force configured to extend draw wire proximal end1242relative to handle proximal end1102. Illustratively, pulley mechanism may1205be configured to change a direction and a point of application of a force from a force configured to extend draw wire proximal end1242relative to handle proximal end1102to a force configured to retract draw wire distal end1241relative to handle proximal end1102. In one or more embodiments, an actuation of actuation lever proximal end1222away from handle proximal end1102may be configured to retract draw wire distal end1241towards handle proximal end1102. Illustratively, an extension of actuation lever proximal end1222and draw wire proximal end1242relative to handle proximal end1102may be configured to retract draw wire1240, e.g., to retract draw wire distal end1241, relative to housing tube700.

In one or more embodiments, a retraction of draw wire1240relative to housing tube700may be configured to cause draw wire1240to apply a compressive force to an inner portion of housing tube700. Illustratively, an application of a compressive force to an inner portion of housing tube700may be configured to gradually compress a portion of housing tube700, e.g., a first housing tube portion720of housing tube700. In one or more embodiments, a gradual compression of a portion of housing tube700may be configured to cause housing tube700to gradually curve. Illustratively, a gradual curving of housing tube700may be configured to gradually curve optic fiber750.

In one or more embodiments, a reduction of a force applied to actuation lever1220may be configured to actuate actuation lever1220, e.g., within actuation channel1120. Illustratively, a reduction of a force applied to actuation lever1220may be configured to rotate actuation lever1220about pivot pin1210. In one or more embodiments, a reduction of a force applied to actuation lever1220may be configured to rotate actuation lever distal end1221and actuation lever proximal end1222about pivot pin1210, e.g., in a clockwise direction. Illustratively, a reduction of a force applied to actuation lever1220may be configured to actuate actuation lever distal end1221away from handle proximal end1102and configured to actuate actuation lever proximal end1222towards proximal end1102. For example, a reduction of a force applied to actuation lever1220may be configured to retract actuation lever proximal end1222relative to handle base1110. In one or more embodiments, a reduction of a force applied to actuation lever1220may be configured to retract draw wire proximal end1242relative to handle proximal end1102.

Illustratively, an actuation of actuation lever proximal end1222towards handle proximal end1102, e.g., due to a reduction of a force applied to actuation lever1220, may be configured to retract draw wire proximal end1242relative to handle proximal end1102. In one or more embodiments, pulley mechanism1205may be configured to change a direction and a point of application of a force configured to retract draw wire proximal end1242relative to handle proximal end1102. Illustratively, pulley mechanism may1205be configured to change a direction and a point of application of a force from a force configured to retract draw wire proximal end1242relative to handle proximal end1102to a force configured to extend draw wire distal end1241relative to handle proximal end1102. In one or more embodiments, an actuation of actuation lever proximal end1222towards handle proximal end1102may be configured to extend draw wire distal end1241away from handle proximal end1102. Illustratively, a retraction of actuation lever proximal end1222and draw wire proximal end1242relative to handle proximal end1102may be configured to extend draw wire1240, e.g., to extend draw wire distal end1241, relative to housing tube700.

In one or more embodiments, an extension of draw wire1240relative to housing tube700may be configured to cause draw wire1240to reduce a compressive force applied to an inner portion of housing tube700. Illustratively, a reduction of a compressive force applied to an inner portion of housing tube700may be configured to gradually decompress a portion of housing tube700, e.g., a first housing tube portion720of housing tube700. In one or more embodiments, a gradual decompression of a portion of housing tube700may be configured to cause housing tube700to gradually straighten. Illustratively, a gradual straightening of housing tube700may be configured to gradually straighten optic fiber750.

FIGS. 13A,13B,13C,13D, and13E illustrate a gradual curving of an optic fiber750.FIG. 13Aillustrates a straight optic fiber1300. In one or more embodiments, optic fiber750may comprise a straight optic fiber1300, e.g., when actuation lever proximal end1222is fully retracted relative to handle base1110. Illustratively, optic fiber750may comprise a straight optic fiber1300, e.g., when first housing tube portion720is fully decompressed. In one or more embodiments, a line tangent to optic fiber distal end751may be parallel to a line tangent to housing tube proximal end702, e.g., when optic fiber750comprises a straight optic fiber1300.

FIG. 13Billustrates an optic fiber in a first curved position1310. Illustratively, an actuation of actuation lever1220, e.g., in a counter-clockwise direction about pivot pin1210, may be configured to gradually curve optic fiber750. For example, an actuation of actuation lever1220, e.g., due to an application of a force to actuation lever1220, may be configured to gradually curve optic fiber750. In one or more embodiments, an application of a force to actuation lever1220may be configured to gradually curve optic fiber750from a straight optic fiber1300to an optic fiber in a first curved position1310. Illustratively, an application of a force to actuation lever1220may be configured to gradually retract draw wire1240relative to housing tube700. In one or more embodiments, a gradual retraction of draw wire1240relative to housing tube700may be configured to cause draw wire1240to apply a compressive force to an inner portion of housing tube700. Illustratively, an application of a compressive force to an inner portion of housing tube700may be configured to compress a first housing tube portion720of housing tube700. In one or more embodiments, an application of a compressive force to an inner portion of housing tube700may be configured to gradually curve housing tube700. Illustratively, a gradual curving of housing tube700may be configured to gradually curve optic fiber750, e.g., from a straight optic fiber1300to an optic fiber in a first curved position1310. In one or more embodiments, a line tangent to optic fiber distal end751may intersect a line tangent to housing tube proximal end702at a first angle, e.g., when optic fiber750comprises an optic fiber in a first curved position1310. Illustratively, the first angle may comprise any angle greater than zero degrees. For example, the first angle may comprise a 45 degree angle.

FIG. 13Cillustrates an optic fiber in a second curved position1320. Illustratively, an actuation of actuation lever1220, e.g., in a counter-clockwise direction about pivot pin1210, may be configured to gradually curve optic fiber750. For example, an actuation of actuation lever1220, e.g., due to an application of a force to actuation lever1220, may be configured to gradually curve optic fiber750. In one or more embodiments, an application of a force to actuation lever1220may be configured to gradually curve optic fiber750from an optic fiber in a first curved position1310to an optic fiber in a second curved position1320. Illustratively, an application of a force to actuation lever1220may be configured to gradually retract draw wire1240relative to housing tube700. In one or more embodiments, a gradual retraction of draw wire1240relative to housing tube700may be configured to cause draw wire1240to apply a compressive force to an inner portion of housing tube700. Illustratively, an application of a compressive force to an inner portion of housing tube700may be configured to compress a first housing tube portion720of housing tube700. In one or more embodiments, an application of a compressive force to an inner portion of housing tube700may be configured to gradually curve housing tube700. Illustratively, a gradual curving of housing tube700may be configured to gradually curve optic fiber750, e.g., from an optic fiber in a first curved position1310to an optic fiber in a second curved position1320. In one or more embodiments, a line tangent to optic fiber distal end751may intersect a line tangent to housing tube proximal end702at a second angle, e.g., when optic fiber750comprises an optic fiber in a second curved position1320. Illustratively, the second angle may comprise any angle greater than the first angle. For example, the second angle may comprise a 90 degree angle.

FIG. 13Dillustrates an optic fiber in a third curved position1330. Illustratively, an actuation of actuation lever1220, e.g., in a counter-clockwise direction about pivot pin1210, may be configured to gradually curve optic fiber750. For example, an actuation of actuation lever1220, e.g., due to an application of a force to actuation lever1220, may be configured to gradually curve optic fiber750. In one or more embodiments, an application of a force to actuation lever1220may be configured to gradually curve optic fiber750from an optic fiber in a second curved position1320to an optic fiber in a third curved position1330. Illustratively, an application of a force to actuation lever1220may be configured to gradually retract draw wire1240relative to housing tube700. In one or more embodiments, a gradual retraction of draw wire1240relative to housing tube700may be configured to cause draw wire1240to apply a compressive force to an inner portion of housing tube700. Illustratively, an application of a compressive force to an inner portion of housing tube700may be configured to compress a first housing tube portion720of housing tube700. In one or more embodiments, an application of a compressive force to an inner portion of housing tube700may be configured to gradually curve housing tube700. Illustratively, a gradual curving of housing tube700may be configured to gradually curve optic fiber750, e.g., from an optic fiber in a second curved position1320to an optic fiber in a third curved position1330. In one or more embodiments, a line tangent to optic fiber distal end751may intersect a line tangent to housing tube proximal end702at a third angle, e.g., when optic fiber750comprises an optic fiber in a third curved position1330. Illustratively, the third angle may comprise any angle greater than the second angle. For example, the third angle may comprise a 135 degree angle.

FIG. 13Eillustrates an optic fiber in a fourth curved position1340. Illustratively, an actuation of actuation lever1220, e.g., in a counter-clockwise direction about pivot pin1210, may be configured to gradually curve optic fiber750. For example, an actuation of actuation lever1220, e.g., due to an application of a force to actuation lever1220, may be configured to gradually curve optic fiber750. In one or more embodiments, an application of a force to actuation lever1220may be configured to gradually curve optic fiber750from an optic fiber in a third curved position1330to an optic fiber in a forth curved position1340. Illustratively, an application of a force to actuation lever1220may be configured to gradually retract draw wire1240relative to housing tube700. In one or more embodiments, a gradual retraction of draw wire1240relative to housing tube700may be configured to cause draw wire1240to apply a compressive force to an inner portion of housing tube700. Illustratively, an application of a compressive force to an inner portion of housing tube700may be configured to compress a first housing tube portion720of housing tube700. In one or more embodiments, an application of a compressive force to an inner portion of housing tube700may be configured to gradually curve housing tube700. Illustratively, a gradual curving of housing tube700may be configured to gradually curve optic fiber750, e.g., from an optic fiber in a third curved position1330to an optic fiber in a fourth curved position1340. For example, a line tangent to optic fiber distal end751may be parallel to a line tangent to housing tube proximal end702, e.g., when optic fiber750comprises an optic fiber in a fourth curved position1340.

In one or more embodiments, one or more properties of a steerable laser probe may be adjusted to attain one or more desired steerable laser probe features. For example, a stiffness of first housing tube portion720or a stiffness of second housing tube portion730may be adjusted to vary an amount of actuation of actuation lever1220configured to curve housing tube700to a particular curved position. Illustratively, a material comprising first housing tube portion720or a material comprising second housing tube portion730may be adjusted to vary an amount of actuation of actuation lever1220configured to curve housing tube700to a particular curved position.

In one or more embodiments, a number of apertures in housing tube700may be adjusted to vary an amount of actuation of actuation lever1220configured to curve housing tube700to a particular curved position. Illustratively, a location of one or more apertures in housing tube700may be adjusted to vary an amount of actuation of actuation lever1220configured to curve housing tube700to a particular curved position. In one or more embodiments, a geometry of one or more apertures in housing tube700may be adjusted to vary an amount of actuation of actuation lever1220configured to curve housing tube700to a particular curved position. Illustratively, a geometry of one or more apertures in housing tube700may be uniform, e.g., each aperture of the one or more apertures may have a same geometry. In one or more embodiments, a geometry of one or more apertures in housing tube700may be non-uniform, e.g., a first aperture in housing tube700may have a first geometry and a second aperture in housing tube700may have a second geometry.

Illustratively, a geometry or shape of actuation lever1220may be adjusted to vary an amount actuation of actuation lever1220configured to curve housing tube700to a particular curved position. In one or more embodiments, one or more locations within housing tube700wherein draw wire1240may be fixed to an inner portion of housing tube700may be adjusted to vary an amount of actuation of actuation lever1220configured to curve housing tube700to a particular curved position. Illustratively, a portion of draw wire1240may be fixed to an outer portion of housing tube700. In one or more embodiments, a portion of draw wire1240may be looped around a portion of housing tube700. Illustratively, a portion of housing tube700may comprise an access window, e.g., configured to allow access to an inner portion of housing tube700. In one or more embodiments, a portion of housing tube700may comprise an access window, e.g., configured to allow access to a portion of optic fiber750or a portion of draw wire1240. Illustratively, at least a portion of optic fiber750may be enclosed in an optic fiber sleeve configured to, e.g., protect optic fiber750, vary a stiffness of optic fiber750, vary an optical property of optic fiber750, etc.

In one or more embodiments, a stiffness of first housing tube portion720or a stiffness of second housing tube portion730may be adjusted to vary a bend radius of housing tube700. Illustratively, a stiffness of first housing tube portion720or a stiffness of second housing tube portion730may be adjusted to vary a radius of curvature of housing tube700, e.g., when housing tube700is in a particular curved position. In one or more embodiments, a number of apertures in housing tube700may be adjusted to vary a bend radius of housing tube700. Illustratively, a number of apertures in housing tube700may be adjusted to vary a radius of curvature of housing tube700, e.g., when housing tube700is in a particular curved position. In one or more embodiments, a location or a geometry of one or more apertures in housing tube700may be adjusted to vary a bend radius of housing tube700. Illustratively, a location or a geometry of one or more apertures in housing tube700may be adjusted to vary a radius of curvature of housing tube700, e.g., when housing tube700is in a particular curved position.

FIGS. 14A,14B,14C,14D, and14E illustrate a gradual straightening of an optic fiber750.FIG. 14Aillustrates a fully curved optic fiber1400. In one or more embodiments, optic fiber750may comprise a fully curved optic fiber1400, e.g., when actuation lever proximal end1222is fully extended relative to handle base1110. Illustratively, optic fiber750may comprise a fully curved optic fiber1400, e.g., when first housing tube portion720is fully compressed. In one or more embodiments, a line tangent to optic fiber distal end751may be parallel to a line tangent to housing tube proximal end702, e.g., when optic fiber750comprises a fully curved optic fiber1400.

FIG. 14Billustrates an optic fiber in a first partially straightened position1410. Illustratively, an actuation of actuation lever1220, e.g., in a clockwise direction about pivot pin1210, may be configured to gradually straighten optic fiber750. For example, an actuation of actuation lever1220, e.g., due to a reduction of a force applied to actuation lever1220, may be configured to gradually straighten optic fiber750. In one or more embodiments, a reduction of a force applied to actuation lever1220may be configured to gradually straighten optic fiber750from a fully curved optic fiber1400to an optic fiber in a first partially straightened position1410. Illustratively, a reduction of a force applied to actuation lever1220may be configured to gradually extend draw wire1240relative to housing tube700. In one or more embodiments, a gradual extension of draw wire1240relative to housing tube700may be configured to cause draw wire1240to reduce a compressive force applied to an inner portion of housing tube700. Illustratively, a reduction of a compressive force applied to an inner portion of housing tube700may be configured to decompress a first housing tube portion720of housing tube700. In one or more embodiments, a reduction of a compressive force applied to an inner portion of housing tube700may be configured to gradually straighten housing tube700. Illustratively, a gradual straightening of housing tube700may be configured to gradually straighten optic fiber750, e.g., from a fully curved optic fiber1400to an optic fiber in a first partially straightened position1410. In one or more embodiments, a line tangent to optic fiber distal end751may intersect a line tangent to housing tube proximal end702at a first partially straightened angle, e.g., when optic fiber750comprises an optic fiber in a first partially straightened position1410. Illustratively, the first partially straightened angle may comprise any angle less than 180 degrees. For example, the first partially straightened angle may comprise a 135 degree angle.

FIG. 14Cillustrates an optic fiber in a second partially straightened position1420. Illustratively, an actuation of actuation lever1220, e.g., in a clockwise direction about pivot pin1210, may be configured to gradually straighten optic fiber750. For example, an actuation of actuation lever1220, e.g., due to a reduction of a force applied to actuation lever1220, may be configured to gradually straighten optic fiber750. In one or more embodiments, a reduction of a force applied to actuation lever1220may be configured to gradually straighten optic fiber750from an optic fiber in a first partially straightened position1410to an optic fiber in a second partially straightened position1420. Illustratively, a reduction of a force applied to actuation lever1220may be configured to gradually extend draw wire1240relative to housing tube700. In one or more embodiments, a gradual extension of draw wire1240relative to housing tube700may be configured to cause draw wire1240to reduce a compressive force applied to an inner portion of housing tube700. Illustratively, a reduction of a compressive force applied to an inner portion of housing tube700may be configured to decompress a first housing tube portion720of housing tube700. In one or more embodiments, a reduction of a compressive force applied to an inner portion of housing tube700may be configured to gradually straighten housing tube700. Illustratively, a gradual straightening of housing tube700may be configured to gradually straighten optic fiber750, e.g., from an optic fiber in a first partially straightened position1410to an optic fiber in a second partially straightened position1420. In one or more embodiments, a line tangent to optic fiber distal end751may intersect a line tangent to housing tube proximal end702at a second partially straightened angle, e.g., when optic fiber750comprises an optic fiber in a second partially straightened position1420. Illustratively, the second partially straightened angle may comprise any angle less than the first partially straightened angle. For example, the second partially straightened angle may comprise a 90 degree angle.

FIG. 14Dillustrates an optic fiber in a third partially straightened position1430. Illustratively, an actuation of actuation lever1220, e.g., in a clockwise direction about pivot pin1210, may be configured to gradually straighten optic fiber750. For example, an actuation of actuation lever1220, e.g., due to a reduction of a force applied to actuation lever1220, may be configured to gradually straighten optic fiber750. In one or more embodiments, a reduction of a force applied to actuation lever1220may be configured to gradually straighten optic fiber750from an optic fiber in a second partially straightened position1420to an optic fiber in a third partially straightened position1430. Illustratively, a reduction of a force applied to actuation lever1220may be configured to gradually extend draw wire1240relative to housing tube700. In one or more embodiments, a gradual extension of draw wire1240relative to housing tube700may be configured to cause draw wire1240to reduce a compressive force applied to an inner portion of housing tube700. Illustratively, a reduction of a compressive force applied to an inner portion of housing tube700may be configured to decompress a first housing tube portion720of housing tube700. In one or more embodiments, a reduction of a compressive force applied to an inner portion of housing tube700may be configured to gradually straighten housing tube700. Illustratively, a gradual straightening of housing tube700may be configured to gradually straighten optic fiber750, e.g., from an optic fiber in a second partially straightened position1420to an optic fiber in a third partially straightened position1430. In one or more embodiments, a line tangent to optic fiber distal end751may intersect a line tangent to housing tube proximal end702at a third partially straightened angle, e.g., when optic fiber750comprises an optic fiber in a third partially straightened position1430. Illustratively, the third partially straightened angle may comprise any angle less than the second partially straightened angle. For example, the third partially straightened angle may comprise a 45 degree angle.

FIG. 14Eillustrates an optic fiber in a fully straightened position1440. Illustratively, an actuation of actuation lever1220, e.g., in a clockwise direction about pivot pin1210, may be configured to gradually straighten optic fiber750. For example, an actuation of actuation lever1220, e.g., due to a reduction of a force applied to actuation lever1220, may be configured to gradually straighten optic fiber750. In one or more embodiments, a reduction of a force applied to actuation lever1220may be configured to gradually straighten optic fiber750from an optic fiber in a third partially straightened position1430to an optic fiber in a fully straightened position1440. Illustratively, a reduction of a force applied to actuation lever1220may be configured to gradually extend draw wire1240relative to housing tube700. In one or more embodiments, a gradual extension of draw wire1240relative to housing tube700may be configured to cause draw wire1240to reduce a compressive force applied to an inner portion of housing tube700. Illustratively, a reduction of a compressive force applied to an inner portion of housing tube700may be configured to decompress a first housing tube portion720of housing tube700. In one or more embodiments, a reduction of a compressive force applied to an inner portion of housing tube700may be configured to gradually straighten housing tube700. Illustratively, a gradual straightening of housing tube700may be configured to gradually straighten optic fiber750, e.g., from an optic fiber in a third partially straightened position1430to an optic fiber in a fully straightened position1440. In one or more embodiments, a line tangent to optic fiber distal end751may be parallel to a line tangent to housing tube proximal end702, e.g., when optic fiber750comprises an optic fiber in a fully straightened position1440.

Illustratively, a surgeon may aim optic fiber distal end751at any of a plurality of targets within an eye, e.g., to perform a photocoagulation procedure. In one or more embodiments, a surgeon may aim optic fiber distal end751at any target within a particular transverse plane of the inner eye by, e.g., rotating handle1100to orient housing tube700in an orientation configured to cause a curvature of housing tube700within the particular transverse plane of the inner eye and varying an amount of actuation of actuation lever1220. Illustratively, a surgeon may aim optic fiber distal end751at any target within a particular sagittal plane of the inner eye by, e.g., rotating handle1100to orient housing tube700in an orientation configured to cause a curvature of housing tube700within the particular sagittal plane of the inner eye and varying an amount of actuation of actuation lever1220. In one or more embodiments, a surgeon may aim optic fiber distal end751at any target within a particular frontal plane of the inner eye by, e.g., varying an amount of actuation of actuation lever1220to orient a line tangent to optic fiber distal end751wherein the line tangent to optic fiber distal end751is within the particular frontal plane of the inner eye and rotating handle1100. Illustratively, a surgeon may aim optic fiber distal end751at any target located outside of the particular transverse plane, the particular sagittal plane, and the particular frontal plane of the inner eye, e.g., by varying a rotational orientation of handle1100and varying an amount of actuation of actuation lever1220. In one or more embodiments, a surgeon may aim optic fiber distal end751at any target of a plurality of targets within an eye, e.g., without increasing a length of a portion of a steerable laser probe within the eye. Illustratively, a surgeon may aim optic fiber distal end751at any target of a plurality of targets within an eye, e.g., without decreasing a length of a portion of a steerable laser probe within the eye.

The foregoing description has been directed to particular embodiments of this invention. It will be apparent; however, that other variations and modifications may be made to the described embodiments, with the attainment of some or all of their advantages. Specifically, it should be noted that the principles of the present invention may be implemented in any probe system. Furthermore, while this description has been written in terms of a steerable laser probe, the teachings of the present invention are equally suitable to systems where the functionality of actuation may be employed. Therefore, it is the object of the appended claims to cover all such variations and modifications as come within the true spirit and scope of the invention.