Sequences of p56, proteins which affect K-ATP channels

This invention describes the full length sequence of human p56 protein (p56-1), a related homolog (p56-2) and the nucleic acids that code for these proteins. The sequences are provided in Charts 1, 2, 3, and 4 and the sequence listings of the application.

FIELD OF THE INVENTION 
This invention relates to potassium channels and the p56 protein. 
INFORMATION DISCLOSURE 
The disclosures appearing in PCT/US95/14124, published May 30, 1996 as WO 
96/16088, particularly page 1, is hereby incorporated by reference. 
Additional documents in the Detailed Description of the invention should 
be considered as part of the Information Disclosure. 
BACKGROUND 
The background appearing in PCT/US95/14124, published May 30, 1996 as WO 
96/16088, particularly pages 1-5, are hereby incorporated by reference. 
The isolation and identification of p56, a protein useful for the 
identification of selective drugs that will selectively open or close K 
channels was described in PCT/US95/14124, published May 30, 1996 as WO 
96/16088. Herein the full length amino acid sequence of p56 and the 
nucleic acid sequence that code for p56 are described. Also described are 
the amino acid sequences and coding DNA that code for p56-2, a different 
p56 protein.. 
SUMMARY OF THE INVENTION 
This invention describes the full length sequence of human p56 protein 
(p56-1), SEQ. ID. NO. 1 a related homolog (p56-2) SEQ. ID. NO. 3 and the 
nucleic acids that code for these proteins SEQ. ID. NOS. 2 and 4. The 
sequences are provided in Charts 1, 2, 3, and 4 and the sequence listings 
of the application SEQ. ID. NOS. 1-4. There are two unique p56 DNA 
sequences and proteins disclosed in this document. For the first p56 
sequence, p56-1, the protein's entire amino acid sequence of p56 is 
provided in Chart 1 SEQ. ID. NO. 1 and the DNA coding for p56 is provided 
in Chart 2 SEQ. ID. NO. 2. For the second sequence, p56-2, the DNA and 
amino acids are disclosed Charts 3 SEQ. ID. NO. 3 and 4 SEQ. ID. NO. 4. 
Equivalents and obvious homologues are disclosed. Also disclosed by 
reference to PCT/US95/14124, published May 30, 1996 as WO 96/16088, hereby 
incorporated by reference, are cloning and other useful vectors for the 
sequence. 
ADDITIONAL DESCRIPTION OF THE INVENTION AND DESCRIPTION OF THE PREFERRED 
EMBODIMENTS 
The entire document numbered PCT/US95/14124, published May 30, 1996 as WO 
96/16088, particularly pages 6-11 are hereby incorporated by reference. 
UTILITY OF THE INVENTION 
The utility of this invention is disclosed and supported by the disclosure 
appearing in PCT/US95/14124, published May 30, 1996 as WO 96/16088, 
particularly ages 11-12 are hereby incorporated by reference.