Tung oil compositions and use for treatment of body deficiencies

Various tung oil or tung oil fatty acid compositions and use thereof for treating at least some symptoms of body defense deficiencies in patients having said symptoms.

TECHNICAL FIELD 
The present invention concerns various tung oil compositions and their use 
in methods for treating and preventing the symptoms of different body 
deficiencies. 
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS 
I have found that the abnormal in general results from the incapacity, 
qualitative or quantitative, of the body to resolve the problem resulting 
from the intervention of a noxious action. I have found that this 
deficiency concerns the incapacity of the body defense to fight 
successfully the occuring condition related to the intervention of lipids, 
and for certain conditions, more specifically of agents having in their 
molecules a trienic conjugated formation. 
I have found that the naturally very efficient defense agents concern fatty 
acids which have in their molecule three trienic conjugated double bonds 
formation, respectively three double bonds separated by single bonds. The 
parallel position of these conjugated trienes especially when part of a 
fatty acid gives the agent a marked efficient defense activity. 
I have found that a such fatty acid represented by the eleostearic acid, is 
naturally present in tung oil (china wood oil) obtained from the seeds of 
Aleuritis Cordata. I have found that the use of the tung oil itself, with 
esters of this acid and also with other fatty acids present represents an 
active, and in the same time, an especially favorable accepted form to be 
administered. 
The study of the pathological conditions has shown that a fatty acid 
defense deficiency is exhibited by a large number of them. They are 
specifically indicated for the administration of the tung oil. The 
following pathological conditions and their symptoms represent conditions 
with such a trienic fatty acids deficiency that can be treated accordingly 
to the invention: neoplastic diseases such as cancer, sarcoma, lymphoma 
and leukemia; infections, microbial, fungal and especially viral as in 
Ebstein - Barr, AIDS, the common cold, influenza and herpes; pain, 
especially acid pain; aging; arteriosclerosis; hypertension; organ 
inflammatory conditions convulsions and epilepsy; certain allergies; 
constipation; manic manifestations and schizophrenia. This enumeration is 
not limitative, any pathological condition with an anabolic-constructive 
imbalance representing a special indication for this treatment. In view of 
the nature of the treatment, according to the invention, the addition of 
other fats or fatty acids, especially those from polyunsaturated oils, 
enhances the activity of the tung oil. 
The association of these polyunsaturated oils or their fatty acids with the 
tung oil or its ester compounds, through a common activity represents a 
progress in their use. Safflower oil, corn oil, cod liver oil, sardine and 
salmon oils, their fatty acids or other unsaturated fatty acids added to 
the tung oil enhances its defense activity The eleostearic acid or its 
salts or esters and the tung oil fatty acids obtained from the tung oil 
through any procedure are other forms of returning to the body the missing 
defense lipids which cause the deficiency. 
The basic nature of the intervention through an induced natural defense has 
led to the administration of the agents of this invention also for the 
general prevention of a diversity of conditions resulting from their 
deficiency. Cancer, arteriosclerosis and aging represent the main 
conditions considered to be prevented by the agents of the invention. 
The main defect of the use of tung oil, its compounds, its fatty acids, or 
the eleostearic acid is the induction of diarrhea. The administration by 
injection reduces this problem, but does not prevent it, especially at 
higher dosages. The addition of commonly available antidiarrhea 
preparations, especially those limited to a local intestinal action, may 
permit the use of higher doses, especially for the administration by 
injection. The addition of the tung oil of other antianabolic compounds 
especially indicated for the condition treated, is manifestly enhancing 
its favorable action. Such compounds comprise mainly bivalent negative 
selenium, bivalent negative sulfur, 3-ketones, fatty acids, fatty 
aldehydes, with or without copper, barium and magnesium incorporated 
therein. This enumeration is not limitative. 
In view of the relationship between defense and the agents of the 
invention, good effects were seen also in conditions with opposite 
catabolic imbalance, especially when treated together with anticatabolic 
agents, especially non sterolic. The oxidation of the tung oil may even 
enhance its activity 
The toxicity studies - acute, subacute and chronic in mice, rats, guinea 
pigs, hamsters and rabbits has shown an acceptance of doses between 500 
and and 2000 times higher than those respectively taken by humans, which 
represents a fairly good condition. No pathological changes and no 
carcinogenic action were seen. 
The usual doses for the different conditions vary according to the 
condition, with usual daily doses orally and by injection, from 50 mg of 
the oil to more than 500 mg. These doses are generally administered twice 
a day or more frequently, if necessary. 
The administration of these formulations are in general limited by the 
appearance of diarrhea. Due to the unique mechanism of intervention, 
through the induction of the main natural defense, the inventions opens a 
new, very broad way in prevention and therapy.

The following examples illustrate the invention. The percentages shown are 
by weight. 
EXAMPLE 1 
Tung oil 20% 
Safflower oil 80% 
For oral administration: 50 mg to 500 mg oil 
mixture per dose given twice per day 
EXAMPLE 2 
Tung oil 5% 
Safflower oil 95% 
Sterile for injection: same amounts as Example 1. 
EXAMPLE 3 
Tung oil fatty acid 20% 
Corn oil fatty acid 20% 
Safflower oil 60% 
For oral administration: same amounts as Example 1. 
EXAMPLE 4 
Tung oil fatty acid 5% 
Safflower oil 95% 
Sterile for injection: same amounts as Example 1. 
While it is apparent that the invention herein disclosed is well calculated 
to fulfill the objects above stated, it will be appreciated that numerous 
modifications and embodiments may be devised by those skilled in the art, 
and it is intended that the appended claims cover all such modifications 
and embodiments as fall within the true spirit and scope of the present 
invention.