Cosmetic compositions having keratolytic and anti-acne activity

A cosmetically acceptable composition with anti-ache or keratolytic activity comprising: 0.01 to 25% by weight of a keratolytic compound complexed to a carrier molecule, 75-99.95 % by weight of a diluent.

TECHNICAL FIELD 
The invention is in the field of cosmetic compositions having keratolytic 
and anti-acne activity. 
BACKGROUND OF THE INVENTION 
Acne vulgaris is reported to be the most common skin disease, affecting 
approximately eighty percent of the teenage population, and in some cases 
persisting into the third and fourth decades of life. The pathology of 
ache is believed to first involve the formation of comedones, which are 
solid, horny masses of tightly packed keratinized cells which plug 
follicles. These comedone plugs are first white when formed (whiteheads), 
but through continued growth and deposition of melanin become blackheads. 
As the comedo enlarges through continued accumulation of keratinized 
cells, pressure builds up within the follicles and they eventually 
rupture, dumping the contents (consisting of horny material, sebum, and 
bacteria) into the skin. This provokes an inflammatory response; when the 
rupture is small pustules or pimples develop, and when the follicle 
completely ruptures cystic nodules result. 
It is well known that acne vulgaris can be treated by application of agents 
which dry and peel the skin to remove keratinous plugs. Well known 
keratolytic agents are sulfur, resorcinol, benzoyl peroxide, salicylic 
acid, and hexachlorophene. Benzoyl peroxide is an antimicrobial agent 
which effectively suppresses the ache bacillus Propionibacteritm aches, an 
organism which has an important causual role in ache. In addition to being 
an effective keratolytic agent, salicylic acid also interferes with the 
formation of blackheads, whiteheads, and the horny masses which clog 
follicles. 
Salicylic acid, benzoyl peroxide, and resorcinol have been incorporated 
into various anti-acne preparations for years. However, due to the acidic 
nature of these ingredients, they often exert undesireable effects on the 
carrier formulation. Salicylic acid, for example, is not water soluble; it 
can only be solubilized in oils or alcohol. When salicylic acid is 
incorporated into these preparations at a pH of above 3, it converts to 
salicylate and causes stability problems in the formulation. Also, 
salicylic acid is light sensitive above a certain pH. Make-ups made with 
salicylic acid are known to fade on exposure to light and can be slightly 
irritating in sensitive skinned individuals who are prone to skin 
irritations. There is therefore a need for anti-acne preparations having 
improved stability and aesthetic properties. 
SUMMARY OF THE INVENTION 
The invention is directed to a cosmetically acceptable composition with 
anti-keratolytic activity comprising: 
0.01 to 25% by weight of a keratolytic compound complexed to a carrier 
molecule, 75-99.99% by weight of a diluent. 
The invention is also directed to a method for treating acne vulgaris 
comprising: 
a) complexing a keratolytic compound to a carrier molecule, 
b) adding an effective amount of said complex of (a) to a cosmetically 
acceptable diluent.

DETAILED DESCRIPTION 
It has most unexpectedly been discovered that if keratolytic compounds, 
particularly those known to also have anti-ache activity are bound to a 
certain carrier molecules, the resulting complex will remain stable in 
cosmetic preparations. When the complex is applied to the skin in a 
cosmetic composition, the keratolytic con, pound becomes disassociated 
from the carrier molecule on the skin and is absorbed into the skin to 
provide the desired anti-acne effect. In the case of salicylic acid, the 
complexation of the salicylic acid in the cosmetic preparation is believed 
to prevent the conversion of salicylic acid to salicylate, and enhances 
the stability and aesthetics of the cosmetic preparation. The various 
ingredients of the cosmetically acceptable composition according to the 
invention are described in more detail below. 
The term "keratolytic compound" means a chemical compound having 
keratolytic and/or anti-acne activity. 
THE ANTI-ACNE ACTIVE 
The keratolytic compounds which are suitable for use with the invention 
contain an acid group or tend to be acidic and are capable of binding with 
the free amino group of a protein or polymer. The binding may be ionic, 
covalent, or through Van Der Waals forces. Anti-acne ingredients capable 
of forming ionic bonds include salicylic acid and resorcinol. Benzoyl 
peroxide will bond to carrier molecules, or bind through Van der Waals 
forces. 
THE CARRIER MOLECULE 
A wide variety of carrier molecules are suitable, so long as the carrier 
molecule possesses at least one free amino group. 
Animal protein or peptides such as collagen, placental proteins, serum 
proteins, amylase, casein, urease, keratin, silk, hydrolyzed animal 
protein, albumin, etc. are well known in the cosmetic art and are capable 
of ionic binding to the keratolytic compound. The preferred carrier 
molecule comprises hydrolyzed animal protein, collagen, or keratin. 
Vegetable or plant proteins or polyamino saccharides containing free amino 
groups are also suitable, such as soya, corn, sweet corn, lupin, wheat 
gluten, guar, oat, extensins, hydrolyzed vegetable proteins, and so on, as 
well as polymers of amino sugars such as chitosan. The preferred carrier 
molecule in this category comprises hydrolyzed vegetable protein, or 
extensins. 
A wide variety of synthetic polymers have free amine groups are also 
suitable as the carrier molecule. Particularly desireable are branched 
polyamidoamines as set forth in U.S. Pat. Nos. 4,435,548, 4,737,550, 
4,871,779, 4,857,599, 4,713,975, 4,694,064, 4,690,985, 4,631,337, 
4,599,400, 4,587,329, 4,568,737, 4,558,120, and 4,507,466 which are hereby 
incorporated by reference. These patents disclose and claim dense 
star-type polymers with dendritic branches which have highly reactive 
substitutent groups. 
Other synthetic polymers such as polyamides, polyanilines, polyureas, 
polyurethanes, and contain at least one free amino group and would be 
suitable carrier molecules. Certain other polymers with free hydroxyl 
groups, such as polyvinyl alcohols, poly (2-HEMA) and poly (2-HPMA) will 
bind by Van der Waals forces. 
COMPLEXATION OF THE KERATOLYTIC COMPOUND TO THE CARRIER MOLECULE 
The keratolytic compound is attached to the carrier molecule employing a 
variety of chemical reactions depending on the carrier molecule and the 
anti-ache active used. The term "complex" refers to the keratolytic 
compound complexed or bound to the carrier molecule. 
Salicylic acid and resorcinol have free acid groups which will ionically 
bond to the tree amino groups of proteins or polymers. Binding of the 
salicylic acid to vegetable or animal proteins is achieved by simply 
combining approximately equal parts of both ingredients in suitable 
vessel. The salicylic acid will react with the free amino groups on the 
carrier molecule to form a complex. Sometimes a slight degree of heat will 
hasten the reaction, or the addition of small amounts of acid such as 
hydrochloric acid. Salicylic acid may also be complexed to various 
carriers such as hydrolyzed vegetable proteins as described in French 
patent no. 2667072 which is hereby incorporated by reference. In 
particular, a concentrated solution of salicylic acid in alcohol is mixed 
with a concentrated solution of hydrolyzed vegetable protein in water. The 
resulting dispersion is mixed under shear or alternatively by ultrasonic 
agitation. Depending on the type of protein selected, the complex may 
precipitate upon forming or may be recovered by vacuum distillation or 
lyophilization by method known to those skilled in the art. The resulting 
powder effectively solubilizes the complexed salicylic acid which can be 
recovered and analyzed as salicylic acid by traditional wet chemistry. 
Alternatively, the salicylic acid can be rendered more water soluble by 
using a metal alkali salt such as sodium or potassium and complexing at a 
pH of 5.5 to 6.5. The powdered hydrolyzed protein is then added to a 
dispersion of the salicylate in a buffered water solution. 
Salicylic acid can be complexed with the dendritic polymers disclosed 
herein. Dendritic polymers are constructed to vary in size and shape 
depending upon the initiator and the molecule used to grow the shell. Of 
particular interest are the starburst dendrimers of the polyamidoamine 
(PAMAM) type because the outer shell is covered with amino groups which 
will complex with salicylic acid. As in example one, the starting point 
can be either a water dispersion of dendrimer to which is added salicylic 
acid in a volatile solvent, or a solution of salicylate at pH 5.5 to 6.5 
to which is added crystals of dendrimers. The size of the dendrimer will 
allow multiple sites for complexation, but not so large that solubility in 
water is hindered. Dendrimers having 1-10 generations are ideal. Since the 
dendrimers can develop holes or irregularities, some salicylic acid may be 
sequestered within the shell as well as complexed to the surface. As with 
the protein, a high complexation ratio is desireable. 
Salicylic acid will also bind to synthetic polymers which have free amino 
groups in a manner similar to binding to proteins. Such polymers include: 
polyamides --(R--CO--NH).sub.n --, polyanilines --(C.sub.6 H.sub.5 
--NH).sub.n --, polyureas (--R--NHCONH).sub.n, and polyurethanes 
--(CO--OR--OCO--NH--R'--NH).sub.n, where the branched or terminal groups 
have free amino groups and the interior amine groups are also available. 
Other polymers with free hydroxy groups will bind to salicylic acid by Van 
der Waals forces. Such polymers are polyvinyl vinyl alcohols --(CH.sub.2 
CHOH)--, poly(2-HEMA), (--CH.sub.2 --C(CH.sub.3)(COOCH.sub.2 
CH(OH)--).sub.n, and poly(2-HPMA), (--CH.sub.2 --C(CH.sub.3)(COOCH.sub.2 
CH.sub.2 OH--).sub.n and (--CH.sub.2 --C(CH.sub.3) (COOCH.sub.2 
CH(OH)CH.sub.3).sub.n. Such bonds are weaker, but may be enhanced by 
shared electrons across the aromatic ring of salicylic acid. Benzoyl 
peroxide will only form Van der Waals bonds with proteins or polymers. The 
complexation of benzoyl peroxide to proteins is achieved by sharing 
electrons across the peroxide moiety and the amido moiety in the polymer. 
It is generally preferred that the complex be comprised of 40-50% by weight 
of anti-acne active and 50-60% by weight of carrier molecule. Ratios may 
vary depending on the effect desired. For example, in some cases it may be 
desired to have small levels of the anti-acne active deposited on the 
skin, in which case more appropriate ratios might range from 10-40% 
anti-acne active/60-90% carrier molecule, or vice versa. 
It may be desired to encapsulate the complex to provide additional 
properties such as time release. Standard encapsulation methods are 
suitable, such as the methods disclosed in U.S. Pat. No. 5,194,262 which 
is hereby incorporated by reference. 
THE DILUENT 
The term "diluent" generally refers to a composition applied externally to 
the skin or hair of the human body for the purpose of cleansing, 
beautitizing, conditioning or protecting the body surface. A wide variety 
of diluents is suitable including but not limited to water-in-oil or 
oil-in-water emulsions in cream or lotion form, sunscreens, toners, 
astringents, facial make-ups, pressed or loose powder, skin cleansing 
compositions, and so on. In some cases it may be desired to apply the 
complex to the scalp to achieve keratolytic effects, so suitable diluents 
can also include shampoos and conditioners. In general, the cosmetically 
acceptable compositions of the invention contain about 0.1-30% of the 
complex and about 70-99.9% diluent. Preferably the compositions comprise 
about 0.1-10% complex and 90-99.9% diluent. 
The complex may be incorporated into creams. Creams generally contain about 
10-90% water and 10-90% oil. The oil may be low or high viscosity surface 
oils, volatile silicones, nonvolatile silicones, or amine functional 
silicones. Creams may also contain humectants, emollients, surfactants, 
emulsifiers, preservatives and fragrances. About 5-10% humectant, 5-20% 
emollient, and about 0.5 
The diluent may be a lotion. Lotions are generally comprised of 20-80% oil 
and 10-80% water in an emulsion form. In addition, lotions may contain 
humectants, emollients, surfactants, fragrances, preservatives and so 
forth. About 5-10% humectant, about 5-20% emollient, and about 0.5-10% 
surfactant are: suggested. 
The diluent may be a make-up. Make-ups generally comprise about 5-70% oil, 
10-95% water, and about 5-40% pigment. In addition, the makeup may contain 
surfactants, silicones as part of the oil phase, humectants, emollients, 
preservatives, fragrances, etc. Generally 0.1 10% surfactant, 0.1-50% 
silicone, 0.1-20% humectant, 0.1-30% emollient, and 0.1-5% preservative is 
suggested. In the preferred embodiment of the invention the diluent is a 
make-up comprising 0.01-50% silicone, 30-60% water, 0.01-40% pigment, and 
5-40% oil. The preferred composition may also comprise 0.1-20% humectant, 
0.1-10% surfactant, and 0.1-5% preservative. 
The make-up of the invention provides improved properties over the 
anti-acne make-ups currently available in that it does not change color or 
fade. Normally anti-acne actives, salicylic acid in particular, react with 
the iron oxide pigments commonly used in make-up. However, because the 
anti-acne active is bound to a carrier molecule, such reaction does not 
occur in the make-up composition of the invention. 
The diluent may also be a blush, face powder, or other anhydrous make-up. 
Generally blushes contain about 5-75% pigment, 1-50% oil, and 1-20% wax. 
They may additionally contain one or more of 10-60% water, 0.5-30% 
surfactant, 1-10% humectants, 0.1-5% preservative, and 0.1-20% silicone. 
Anhydrous makeups and concealers generally comprise one or more of 0.1-10% 
surfactant, 0.1-50% silicone, 0-20% humectant, 0.1-30% emollient, 0.1-50% 
pigme and 0.01-20% pigments. They may also contain one or more of 10-60% 
water, 0.5-30% surfactant, 1-10% humectants, 0.1-5% preservative, and 
0.1-20% silicone. 
The diluent may be a shampoo when it is desired to apply the anti-ache 
active (which also has keratolytic activity) onto the scalp. Suitable 
shampoo compositions contain 1-40% of a cleansing surfactant and 10-90% 
water. Preferably the surfactants are anionic or amphoteric. The shampoo 
may also contain any one of ingredients such as surfactants, colorants, 
preservatives, fragrance, emulsifiers, viscosity adjusters, and 
conditioning agents. If present, suitable ranges are 0.01-30% surfactant, 
0.001-5% colorant, 0.001-5% preservative, 0.01-15% emulsifiers, 0.01-10% 
viscosity adjusters, and 0.1-20% conditioning agents. 
The diluent may also be a hair conditioner. Suitable hair conditioning 
formulations include 10-95% water, 0.5-30% conditioning ingredients such 
as quaternary ammonium compounds or amphoteric polymers, proteins, etc., 
and 1-40% surfactants. Hair conditioners may also contain volatile or 
nonvolatile silicones; an amount of about 0.5-15% is suggested. 
The diluent may be a toner which generally comprises about 0-85% alcohol, 
0.01-5% surfactant, and 0.1-5% humectants, 0.1-85% water. 
The diluent may also be pharmaceutical type vehicles such as ointments, 
gels or solutions. Suitable ointments are hydrophilic ointments (USP) or 
petroleum. Solutions are made by mixing the anti-ache active/carrier 
molecule complex in deionized water. Gels generally comprised about 1-90% 
water and about 1-90% of a suitable polymer such as polypropylene, etc. 
Suitable emollients include glyceryl stearate, cetyl alcohol, stearyl 
alcohol, isopropyl stearate, stearyl stearate, isopropyl stearate, stearic 
acid, isobutyl pahnitate, isocetyl stearate, oleyl alcohol, sebacates, 
myristates, palmitates, squalenes, glyceryl monooleate, oleic acids, 
lanolin, acetylated lanolin alcohols, petroleum, mineral oils, palmitic 
acids, isostearyl neopentanoate, etc., as well as those set forth on pages 
79-81 of the C.T.F.A. Cosmetic Ingredient Handbook, First Edition, 1988, 
which is hereby incorporated by reference. 
Suitable humectants include glycerin, butylene glycol, propylene glycol, 
glucose, fructose, glucuronic acid, glueamine, glutamic acid, glycereth-7, 
glycereth-12, glycereth-26, histidine, honey lactose, mannitol methyl 
gluceth, sodium PCA PEG-10 propylene glycol, urea, xylitol, TEA-lactate, 
TEA-PCA, sucrose, sorbitol, PCA, sodium lactate, or mixtures thereof, as 
well as those set forth on page 75 of the C.T.F.A. Cosmetic Ingredient 
Handbook, First Edition, 1988, which is hereby incorporated by reference. 
A variety of surfactants may be used in the diluent including amphoteric, 
anionic, cationic or nonionic surfactants. Suitable amphoteric surfactants 
include imidazolines, betaines, and amino acid salts. Suitable anionic 
surfactants include fatty acid soaps, salts of higher alkyl sulfates, 
n-acyl sarcosinates, salts of phosphates, sulfosuccinates salts, alkyl 
benzene sulfonates, salts of N-acyl glutamate, polyoxyethylene alkyl ether 
carboxylic acids, and so on. Cationic surfactants include alkyl trimethyl 
ammonium salts, alkyl pyridinium salts, alkyl quaternary ammonium salts, 
polyamine fatty acid derivatives, etc. Suitable anionic and amphoteric 
surfactants also include those designated as "cleansing agents" as set 
forth on pages 87-90 of the C.T.F.A. Cosmetic Ingredient Handbook, First 
Edition, 1988, which is hereby incorporated by reference. Nonionic 
surfactants include lipophilics such as sorbitan fatty acid esters, 
glycerol fatty acids, propylene glycol fatty acid esters; hydrophilics 
such as polyoxyethylene sorbitan fatty acid esters, polyoxyethylene 
glycerol fatty acid esters, polyoxyethylene fatty acid esters, 
polyoxyethylene alkyl ethers, pluronics, polyoxyethylene alkyl phenyl 
ethers, polyoxyethylene propylene glycol fatty acid esters, and so on. 
Examples of nonionic surfactants include those set forth in pages 90-94 of 
the C.T.F.A. Cosmetic Ingredient Handbook, First Edition, 1988, which is 
hereby incorporated by reference. Suitable cationic surfactants are set 
forth on page 97 of the C.T.F.A. Cosmetic Ingredient Handbook, First 
Edition, 1988, which is hereby incorporated by reference. 
Suitable pigments include organic and inorganic pigments such as talc, 
mica, titanium dioxide, titanated mica, iron oxides, ultramarines, 
chromium oxides, carmine, D&C and FD&C colors and lakes, ferric and 
ferrous oxides, and so on, as set forth on pages 33 and 63 of the C.T.F.A. 
Cosmetic Ingredient Handbook, First Edition, 1988, which is hereby 
incorporated by reference. 
Suitable preservatives include the ureas such as imidazolidinyl urea, 
diazolidinyl urea, the parabens, quaternium 15, benzyl alcohol, 
phenoxyethanol and so on. 
Suitable waxes include beeswax, cetyl esters, carnauba, ceresin, 
microcrystalline, lanolin, paraffin, ozokerite, lanolin alcohol, 
acetylated lanolin, candelilla, cetyl alcohol, cocoa butter, petrolatum, 
hydrogenated castor oil, spermacetic, bran wax, capok wax, bayberry, 
hydrogenated jojoba oil, hydrogenated jojoba wax, hydrogenated rice bran 
wax, japan wax, jojoba butter, jojoba oil, mink, montan acid, montan, 
ouricury, shellac, etc. 
Suitable silicones include cyclomethicone, dimethicone, stearoyl 
dimethicone, phenyl trimethicone, dimethiconol, dimethicone copolyols, 
etc. 
In the preferred embodiment of the invention the anti-ache active/carrier 
molecule complex comprises 40-50% by weight plant protein (hydrolyzed 
vegetable protein) and 45-55% salicylic acid. The preferred diluent is a 
make-up or skin care product. 
EXAMPLE 1 
A concentrated solution of hydrolyzed vegetable protein in water is mixed 
with a 50% salicylic acid solution in ethanol. The resulting dispersion is 
mixed under shear. The mixture is allowed to stand for approximately 24 
hours. Lyophilization is performed to yield a powdered material which 
comprises salicylic acid complexed to the hydrolyzed vegetable protein. 
EXAMPLE 2 
A water dispersion of about 50wt% polyamidoamine methacrylate crystals in 
water is prepared. A solution of 50% salicylic acid in ethanol is slowly 
added to the crystals with stirring for a half hour. The mixture is vacuum 
distilled to yield crystals having salicylic acid complexed thereto. 
EXAMPLE 3 
A concentrated dispersion of polyacrylamide in water is mixed with a 50% 
solution of salicylic acid in ethanol with high shear mixing. After 24 
hours the resulting dispersion is lyophilized to yield crystals having 
salicylic acid complexed thereto. 
EXAMPLE 4 
A 50% solution of benzoyl peroxide in ethanol is mixed with a 25% solution 
of hydrolyzed vegetable protein. The mixture is allowed to stand for 24 
hours. The mixture is then lyophilized to obtain a powder. The powder 
comprises hydrolyzed vegetable protein having benzoyl peroxide complexed 
thereto. 
EXAMPLE 5 
The salicylic complex of Example 1 was used to prepare a make-up 
composition as follows: 
______________________________________ 
w/w % 
______________________________________ 
Salicylic acid/hydrolyzed veg. protein complex 
1.00 
Trisodium EDTA 0.15 
Benzoic acid 0.20 
1,3-butylene glycol 5.00 
Sodium polymethacrylate 1.00 
Sorbitan sesquioleate 0.50 
Simethicone 0.15 
Glycerin 5.00 
Magnesium aluminum silicate 
1.25 
Methyl paraben 0.30 
Ethyl paraben 0.10 
Polyethylene 2.00 
Nylon 12 3.00 
Rutile titanium dioxide 5.00 
Black iron oxide/talc 0.53 
Red iron oxide/talc 0.92 
Yellow iron oxide 0.69 
Talc 3.44 
Xanthan gum 0.35 
Cyclomethicone 15.00 
Diisopropyl linoleate 3.50 
Polysorbate 20 1.00 
Water 0.70 
Imidazolidinyl urea 0.30 
______________________________________ 
Water was heated to 60-65C. Salicylic acid/hydrolyzed vegetable protein 
complex, trisodium ETDA, benzoic acid, 1,3-butylene glycol, sodium 
polymethacrylate, sorbitan sesquioleate, simethicone, glycerin, magnesium 
aluminum-silicate, methyl paraben, ethyl paraben, polyethylene, nylon 12, 
the oxides, talc and xanthan gum were mixed in a colloid mill until all 
ingredients were dispersed. The mixture was then heated in a steam bath to 
68-70.degree. C. using a sweep mixer. Next combined were the oil phase 
ingredients: cyclomethicone, diisopropyl linoleate and polysorbate 20. The 
mixture was heated in a steam bath to 68-70.degree. C. When the water and 
oil phases were at the same temperature, they were mixed with sweep action 
to form the emulsion. Sweep mixing was continued at the maintenance 
temperature for 15-20 minutes. The mixture was then removed from the bath 
and allowed to cool while maintaining mixing. The urea was added when the 
batch temperature reach 40-45.degree. C. 
EXAMPLE 6 
An oil in water moisturizing lotion is made as follows: 
______________________________________ 
w/w % 
______________________________________ 
Glyceryl stearate 3.0 
PPG-10 lanolin ether 0.5 
Mineral oil 6.3 
Lanolin alcohol 0.7 
Oleic acid 2.7 
Isocetyl stearate 10.00 
Triethanolamine 1.3 
Carbomer 941 0.1 
Glycerin 4.0 
Preservative 0.4 
Salicylic acid/hydrolyzed vegetable protein complex 
5.00 
QS water 100.00 
______________________________________ 
The lotion was made by mixing into about 30 grams of water the remaining 
ingredients. The composition was emulsified and water added to 100 grams. 
EXAMPLE 7 
An oil-in-water moisturizing cream is made as follows: 
______________________________________ 
w/w % 
______________________________________ 
Glyceryl stearate 5.0 
Cetyl alcohol 2.0 
Stearyl alcohol 2.0 
Isopropyl stearate 4.0 
Mineral oil 12.0 
Polysorbate 60 1.0 
Glycerin 8.0 
Xanthan gum 0.25 
Preservative 0.60 
Salicylic acid/hydrolyzed vegetable protein complex 
5.00 
Water QS 100.00 
______________________________________ 
The ingredients were combined and mixed to emulsify. 
EXAMPLE 8 
An anhydrous makeup with salicylic acid was made as follows: 
______________________________________ 
w/w % 
______________________________________ 
Stearoyl dimethicone 12.00 
Phenyl trimethicone 16.00 
Octyldodecanol 12.00 
Dimethicone 4.00 
BHA 0.10 
Phenoxyethanol 0.70 
Titanium dioxide 15.00 
Black iron oxide/talc 0.26 
Red iron oxide/talc 2.00 
Yellow iron oxide/talc 5.00 
Talc 6.94 
Lecithin treated mica 6.00 
Hydrogenated coco glycerides 
10.00 
Ceresin wax 1.00 
Tribehenin 8.00 
Salicylic acid/hydrolyzed vegetable protein 
1.00 
protein complex 
______________________________________ 
All ingredients except the complexed salicylic acid/protein was mixed in a 
steam bath until waxes were molten. The entire batch was roller milled 
until pigments were dispersed. The mixture was then returned to the steam 
bath anti the salicylic acid complex was added. The batch was prop mixed 
until cooled to room temperature. 
EXAMPLE 9 
An anhydrous concealer stick was made as follows: 
______________________________________ 
w/w % 
______________________________________ 
Ceresin wax 15.00 
Carnauba 2.00 
Wax blend 4.00 
Microcrystalline wax 2.50 
Ester blend 30.00 
Prepolymer 2 10.00 
Octyldodecanol 13.00 
Sorbitan sesquioleate 1.00 
Octyldodecyl stearoyl stearate 
2.00 
Bismuth oxychloride 2.00 
Polymethylmethacrylate 3.00 
Talc 5.70 
Lecithin treated black I.O. 
1.00 
Lecithin treated red I.O. 
2.00 
Lecithin treated yellow I.O. 
5.00 
Phenoxyethanol 0.70 
BHA 0.10 
Salicylic acid/hydrolyzed vegetable protein 
1.00 
complex 
______________________________________ 
All ingredients except the salicylic acid/protein complex were mixed in a 
steam bath until waxes were molten. The entire batch was roller milled 
until pigments were dispersed. The batch was returned to the steam bath 
and the salicylic acid complex was added. The batch was prop mixed until 
it cooled to room temperature. 
EXAMPLE 10 
A shampoo composition was made as follows: 
______________________________________ 
w/w % 
______________________________________ 
Ammonium lauryl sulfate 10.00 
Cocamide diethanolamine 4.00 
Cocamidopropyl betaine 4.00 
Ammonium chloride 0.80 
Citric acid 0.10 
Salicylic acid/hydrolyzed vegetable protein complex 
5.00 
Water QS 100.00 
______________________________________ 
EXAMPLE 11 
A creme rinse hair conditioner was made as follows: 
______________________________________ 
w/w % 
______________________________________ 
Stearalkonium chloride 2.0 
Cetyl alcohol 1.0 
Stearyl alcohol 0.5 
Ceteareth 20 2.0 
Xanthan gum 0.5 
Citric acid 0.3 
Dimethicone 0.2 
Salicylic acid/hydrolyzed vegetable protein complex 
5.00 
Water QS 100.00 
______________________________________ 
EXAMPLE 12 
A toner composition was made as/follows: 
______________________________________ 
w/w % 
______________________________________ 
Polysorbate 20 1.0 
Ethyl alcohol 50.00 
Perfume 8.00 
Salicylic acid/hydrolyzed vegetable protein complex 
10.00 
Water QS 100.00 
______________________________________ 
EXAMPLE 13 
A cleansing cream was made as follows: 
______________________________________ 
w/w % 
______________________________________ 
Mineral oil 20.00 
Beeswax 2.00 
Polysorbate 40 8.00 
PEG 20 sorbitan beeswax 2.00 
Stearic acid 10.00 
Petrolatum 4.00 
Sorbitol 5.00 
Perfume 1.00 
Preservative 0.50 
Salicylic acid/hydrolyzed veg. protein complex 
10.00 
Water QS 100.00 
______________________________________