Endoscopic vessel harvesting system components

Components for an endoscopic vessel harvesting system suitable for harvesting target vessels such as the saphenous vein or radial artery for cardiac artery bypass graft surgery. The main components of such systems include a vessel dissector and a vessel harvester, both of which work in conjunction with a separately provided endoscope. The vessel dissector is an elongated cannula having a blunt tip for separating layers of facial around vessels. The tip may be movable, and is typically transparent to permit viewing forward of the tip using the endoscope. Internal features of the tip may reduce glare back to the endoscope. Several devices improve visibility through the tip by reducing interference from tissue or fluid on the tip. The vessel harvester also has an elongated cannula for receiving the endoscope. Several tools within the harvester permit manipulation, severing, and sealing of vessels forward of the distal end. The tool for manipulating vessels may have a low-profile for increased visibility of operation, and may be coupled to the cannula with a damping mechanism to reduce the possibility of avulsion of the vessels. Various vessel cutting and sealing devices are provided that may accommodate various sizes of vessels and improve cutting and sealing efficacy.

FIELD OF THE INVENTION

The present invention relates to surgical devices and methods for dissection and removal of blood vessels from a patient's body and, in particular, to endoscopic vessel harvesting systems, components and methods.

BACKGROUND OF THE INVENTION

Endoscopic harvesting of vessels is well known in the surgical field and has been the subject of a great deal of recent technological advancement. Typically, the harvested vessel is used for bypass or as a shunt around an artery that has diminished flow from stenosis or other anomaly, such as in a Coronary Artery Bypass Grafting (CABG) procedure. Often in CABG, a saphenous vein from the patient's leg is harvested for subsequent use in the surgery. Other vessels, such as the radial artery, can also be harvested and used in this manner. Vessel harvesting involves liberating the vessel from surrounding tissue and transecting smaller side branches, cauterizing, tying or ligating the vessel at a proximal site and a distal site, and then transecting the vessel at both sites before it is removed from the body.

Known endoscopic methods and devices for performing vessel harvesting are discussed in detail in U.S. Pat. No. 6,176,825 to Chin, et al., Re 36,043 to Knighton, U.S. Pat. No. 6,406,425 to Chin, et al., and U.S. Pat. No. 6,471,638 to Chang, et al., all of which are expressly incorporated herein by reference. Furthermore, various devices and methods disclosed in U.S. Pat. No. 5,895,353 to Lunsford, et al., and U.S. Pat. No. 6,162,173 to Chin, et al., and pending patent application Ser. No. 10/602,490 entitled “Apparatus and Method for Integrated Vessel Ligator and Transector” are also expressly incorporated herein by reference. Also, commercial vessel harvesting systems sold under the tradename VASOVIEW® Uniport Plus, VASOVIEW® 5, VASOVIEW® 6, and VASOVIEWS 7 are available from Guidant Corporation of Santa Clara, Calif.

Another version of an endoscopic vessel harvesting system is disclosed in U.S. Patent Publication No. 2003/0130674 to Kasahara, et al., filed on Dec. 24, 2002, or and later updated in U.S. Patent Publication No. 2005/0159764 also to Kasahara, et al., filed Oct. 27, 2004. In these systems, various devices are utilized to first dissect a vein from surrounding tissue and then harvest the vein. Each of the devices passes through a guide tube of a trocar inserted through a body surface, such as disclosed in U.S. Pat. No. 6,863,674 also to Kasahara, et al., filed Dec. 23, 2002. Certain elements of these and other related patent disclosures are evident in the VirtuoSaph™ endoscopic vein harvesting system (see, www.terumo-cvs.com/products) marketed by Terumo Cardiovascular Systems Corp. of Japan.

Despite accepted endoscopic vessel harvesting systems and techniques, there remains a need for systems and components that both make the user's task less complicated and improve the surgical outcome.

SUMMARY OF THE INVENTION

The present invention provides an endoscopic vessel harvesting system suitable for harvesting various target vessels that allows for simple and convenient operation in a limited space. The invention includes improvements to various components of vessel harvesting systems each of which can be used with any of the other component improvements. It should be understood, therefore, that even if a particular combination is not explicitly described, any one component can be used with any other component disclosed herein unless that combination is structurally impossible.

In accordance with a first embodiment, the present invention provides a vessel dissector that is used in conjunction with an endoscope, comprising an elongated cannula including a lumen therein for receiving the endoscope, the elongated cannula further housing a passage for delivery of an insufflation gas therethrough. The vessel dissector has an input for connecting to a supply of insufflation gas, the input being in fluid communication with the passage. A port opens near the distal end of the elongated cannula in fluid communication with the passage and out of which insufflation gas is expelled. A fluid barrier covers the port that permits expulsion of insufflation gas from the passage within the elongated cannula and prevents ingress of fluid from outside the elongated cannula through the port to the passage.

The port may be formed in the side of the elongated cannula. Desirably, the fluid barrier comprises a tubular member surrounding the distal end of the elongated cannula and covering the port. In one embodiment, the fluid barrier comprises a polymer shield that closes off the port from the outside but is flexible so that insufflation gas may escape from the passage therethrough. In another embodiment, the fluid barrier comprises a gas-permeable liquid-resistant membrane that permits escape of insufflation gas therethrough but prevents entrance of fluid to the passage.

The vessel dissector may further include a transparent conical tip on a distal end of the elongated cannula that permits an operator of the dissector to dissect tissue while viewing internal body structures via an objective lens of the endoscope positioned close to the blunt tip. The insufflation gas port may be located at the apex of the conical tip. The vessel dissector may also have a coupling between the distal end of the elongated cannula and the transparent blunt tip and a control member extending through the elongated cannula to enable the user to angle the tip relative to the axis of the elongated cannula. For instance, the coupling may be an accordion-like flexible interface or sleeve, or a spherical bearing surface.

In accordance with a second embodiment, the present invention provides a vessel dissector that is used in conjunction with an endoscope, comprising an elongated cannula including a lumen therein for receiving the endoscope. A hollow outwardly conical transparent dissecting tip on a distal end of the elongated cannula permits an operator of the dissector to dissect tissue while viewing internal body structures via an objective lens of the endoscope. The tip comprises a structure generally arranged about an axis and having an inner wall that terminates at a distal end in a shape that tends to reduce glare back to the objective lens of the endoscope in comparison to a conical inner wall that tapers symmetrically to an apex. For example, the shape of the distal end of the inner wall of the dissecting tip may be an inner tapering surface that terminates at its distal end in a line so as to form an elongated inner corner, an inner surface that tapers downward toward its distal end and terminates in a flat surface set at an angle from the axis of the tip, or a backward wedge. Desirably, the dissecting tip has a tip diameter and the elongated cannula has a diameter adjacent the dissecting tip that is between about 50-75% of the tip diameter.

In a more robust system, the vessel dissector may also include a vessel holding tool extending through the elongated cannula and adapted for longitudinal movement therein, and a vessel severing tool such as a tissue welder extending through the elongated cannula and adapted for longitudinal movement therein. In this embodiment, the dissecting tip includes apertures for passage of the vessel holding tool and the vessel severing tool. Preferably, both the vessel holding tool and the vessel severing tool dock into recesses in the dissecting tip and have exterior shapes that conform to the conical exterior of the dissecting tip so as to match its shape.

In accordance with a third embodiment, the present invention provides a vessel dissector that is used in conjunction with an endoscope. The vessel dissector is defined by an elongated cannula including a lumen therein for receiving the endoscope. A transparent blunt tip on a distal end of the elongated cannula permits an operator of the dissector to dissect tissue while viewing internal body structures via an objective lens of the endoscope. A wiper clears tissue from the exterior of the transparent blunt tip. The wiper may be arranged on the elongated cannula to pivot about an axis to alternately contact and disengage from the transparent blunt tip, and a mechanism for rotating the blunt tip. Alternatively, the wiper is arranged on the elongated cannula to contact the blunt tip and swivel about the axis of the device. Still further, the wiper may be an O-ring wiper fitted over the blunt tip and connected to an actuation rod that displaces the O-ring wiper longitudinally to wipe over the blunt tip. In one embodiment, the wiper is arranged on the elongated cannula to contact the blunt tip and has an energized cutting electrode thereon to remove tissue via ablation. Preferably, a handle disposed at a proximal end of the elongated cannula has a thumb lever thereon connected to an actuating rod for displacing the wiper relative to the transparent blunt tip and clearing tissue therefrom.

In accordance with a fourth embodiment, a vessel harvester used in conjunction with an endoscope comprises an elongated cannula including a lumen therein for receiving the endoscope, and a vessel holding tool extending through the elongated cannula and adapted for longitudinal movement therein. A distal end of the vessel holding tool includes a vessel hook and a locking member used to capture a target vessel, wherein the hook is open on one side and extension of the locking member closes the open side so that the target vessel is completely surrounded and captured therein. A vessel severing tool extends through the elongated cannula for longitudinal movement therein, and has a distal operative end with structure for severing a target vessel. The vessel holding tool includes a support rod that extends through the elongated cannula and which is configured to angle laterally at a location close to the distal end of the tool to enable lateral vessel manipulation and improve positioning of the vessel severing tool relative to the target vessel.

Desirably, the support rod is bent out of a plane in which the support rod lies at a location close to the distal end of the vessel holding tool such that the distal end angles either toward or away from the vessel severing tool. The support rod may be flexible such that the bend is retracted into the cannula and distal extension of the vessel holding tool from the end of the elongated cannula displaces its distal end laterally. A flexible support rod may be surrounded by a rigid hypotube also adapted for longitudinal movement with respect to the cannula, wherein extension of both the support rod and hypotube from the cannula and then retraction of the hypotube from around the support rod angles the vessel holding tool. Alternatively, the support rod is bent out of a plane in which the support rod lies at a location close to the distal end of the vessel holding tool using an active angling mechanism controlled from a proximal end of the elongated cannula.

The vessel hook of the vessel holding tool may include a blunt tapered distal dissecting surface for blunt dissection of tissue. Further, the vessel hook of the vessel holding tool defines a space therein for receiving a target vessel, and the locking member may be shaped as a large wedge to reduce the space within the open vessel hook by about 50% and includes a tapered leading edge that helps prevent pinching of the target vessel as the locking member extends.

In accordance with a fifth embodiment, the present invention provides a vessel harvester that is used in conjunction with an endoscope, comprising an elongated cannula including a lumen therein for receiving the endoscope. A vessel severing tool extends through the elongated cannula for longitudinal movement therein, the severing tool having a distal operative end with structure for severing a target vessel. A vessel holding tool also extends through the elongated cannula for longitudinal movement therein and has a single support rod that extends through the elongated cannula and a distal end with a vessel hook and a locking member used to capture a target vessel and manipulate it to present a side branch of the target vessel to the vessel severing tool. The hook is open on one side and extension of the locking member closes the open side so that the target vessel is completely surrounded and captured therein. The locking member extends concentrically from the single support rod on one lateral side of the vessel hook, the single support rod therefore reducing endoscopic viewing impediments relative to more than one support rod.

The support rod may be configured to angle laterally at a location close to the distal end of the tool to enable lateral vessel manipulation and improved positioning of the vessel severing tool relative to the target vessel. Desirably, the vessel hook of the vessel holding tool includes a blunt tapered distal dissecting surface for blunt dissection of tissue.

In accordance with a sixth embodiment, the present invention provides a vessel harvester that is used in conjunction with an endoscope, comprising an elongated cannula including a lumen therein for receiving the endoscope. A vessel severing tool extends through the elongated cannula for longitudinal movement therein, the severing tool having a distal operative end with structure for severing a target vessel. A vessel holding tool also extends through the elongated cannula for longitudinal movement therein. The vessel holding tool has a support rod that extends through the elongated cannula and a distal end with a vessel hook and a locking member used to capture a target vessel and manipulate it to present a side branch of the target vessel to the vessel severing tool. The hook is open on one side and extension of the locking member closes the open side so that the target vessel is completely surrounded and captured therein. The distal end of the vessel holding tool including the hook and locking member are constructed of a thin wireform for reduced impediment to endoscopic viewing. Preferably, the thin wireform is formed of metal or plastic wires having a thickness of between about 0.5 mm and 1.0 mm. Desirably, the support rod is configured to angle laterally at a location close to the distal end of the tool to enable lateral vessel manipulation and improved positioning of the vessel severing tool relative to the target vessel.

In accordance with a seventh embodiment, the present invention provides a vessel harvester that is used in conjunction with an endoscope, comprising an elongated cannula including a lumen therein for receiving the endoscope. A vessel severing tool extends through the elongated cannula for longitudinal movement therein, the severing tool having a distal operative end with structure for severing a target vessel. A vessel holding tool also extends through the elongated cannula for longitudinal movement therein. The vessel holding tool has a support rod that extends through the elongated cannula and a distal end with a vessel holder used to capture a target vessel and manipulate it to present a side branch of the target vessel to the vessel severing tool. A damped slip mechanism provided around the support rod of the vessel holding tool permits relative movement between the cannula and the support rod if the vessel holder catches on any body structure and generates a reaction force in the support rod in opposition to movement of the cannula. For instance, the damped slip mechanism comprises a friction collar surrounding the support rod, or a piston/cylinder/spring arrangement that couples movement of the support rod and cannula.

In a preferred embodiment wherein the vessel holder of the vessel holding tool is open on one side and defines a space therein for receiving a target vessel. A locking member moves to close the open side of the holder so that the target vessel is completely surrounded and captured therein. The locking member is shaped as a large wedge to reduce the space within the open vessel holder by about 50% and includes a tapered leading edge that helps prevent pinching of the target vessel as the locking member moves. Also, the vessel holding tool has improved visibility by virtue of a single support rod that extends through the elongated cannula, wherein the locking member extends concentrically from the single support rod on one lateral side of the vessel holder, the single support rod therefore reducing endoscopic viewing impediments relative to more than one support rod. Desirably, the distal end of the vessel holding tool including the holder and locking member are constructed of a thin wireform for reduced impediment to endoscopic viewing.

In accordance with an eighth embodiment, the present invention provides a vessel harvester that is used in conjunction with an endoscope, comprising an elongated cannula including a lumen therein for receiving the endoscope. A vessel severing tool extends through the elongated cannula for longitudinal movement therein, the severing tool has a distal operative end with an open mouth for receiving a target vessel that automatically accommodates widely varying sizes of vessel, and a severing device associated with the mouth. A vessel holding tool extends through the elongated cannula for longitudinal movement therein, the vessel holding tool having structure used to capture a target vessel and manipulate it to relative to the vessel severing tool. The mouth of the vessel severing tool preferably accommodates vessels having diameters that range from between 0.5 and 1.0 mm.

In one embodiment, the mouth has facing vessel contacts that flex apart upon receiving a vessel therebetween. The severing device may have bipolar electrodes disposed to contact a target vessel received within the mouth. For instance, the bipolar electrodes comprise wire electrodes arranged in a crossing pattern in the mouth. In another version, the mouth has a stepped shape with several progressively smaller intermediate gaps having generally parallel sides that provide regions of constant width surface contact with the vessel. The intermediate gaps may have widths in decreasing increments of 1.0 mm. The severing device may be a mechanical cutter disposed transverse to a target vessel received within the mouth. For efficacy, a fluid conduit terminates close to the distal operative end of the vessel severing tool and is adapted to deliver a fluid jet to knock away tissue that may stick to the distal operative end.

The vessel severing tool may be connected to a control rod and located within an arcuate slot formed in the elongated cannula, the control rod being capable of translating the distal operative end laterally within the arcuate slot as well as longitudinally. The mouth of the vessel severing tool may open to one side of the distal operative end. The vessel holding tool may includes a support rod that extends through the elongated cannula and is bent out of a plane in which the support rod lies at a location close to the distal end of the vessel holding tool such that the distal end angles either toward or away from the vessel severing tool.

In accordance with a ninth embodiment, the present invention provides a vessel harvester that is used in conjunction with an endoscope, comprising an elongated cannula including a lumen therein for receiving the endoscope. A pair of partial tubular vessel shields extend from the cannula and define a lumen sized to receive a target vessel, the partial tubular vessel shields defining gaps therebetween sized to receive a side branch extending from the target vessel. A tubular cutting element sized to surround the partial tubular vessel shields and axially displaceable from the cannula, advances to sever any side branch received within the gaps while the partial tubular vessel shields protect the target vessel from the severing operation. The vessel severing tool may be a tubular knife blade. A fluid conduit terminating close to the partial tubular vessel shields may be adapted to deliver a fluid jet to knock away tissue that may stick to the vessel shields.

In accordance with a tenth embodiment, the present invention provides a vessel harvester that is used in conjunction with an endoscope, comprising an elongated cannula including a lumen therein for receiving the endoscope. A pair of fork-shaped vessel sealing electrodes having tines are spaced laterally apart so as to create a gap therebetween. A vessel capturing mandible moves within the gap between the electrodes to capture a target vessel positioned between the tines. A severing blade moves within the gap and sever the target vessel. Desirably, the vessel capturing mandible has a serrated distal finger to securely capture the target vessel within the tines. Both of the vessel capturing mandible and severing blade may have control rods and angled proximal surfaces that cam against a distal end of the elongated cannula and displace them toward one another upon proximal retraction of the control rods. A fluid conduit terminating close to the fork-shaped vessel sealing electrodes may deliver a fluid jet to knock away tissue that sticks to the sealing electrodes.

A further understanding of the nature and advantages of the present invention are set forth in the following description and claims, particularly when considered in conjunction with the accompanying drawings in which like parts bear like reference numerals.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

The present application provides a number of improvements to prior art vessel harvesting systems. The disclosures herein of various component parts of vessel harvesting systems should be viewed with the presumption that each can work in combination with other components unless stated as being mutually exclusive. For example, the various endoscopic vessel dissectors described herein may be utilized in combination with any of the endoscopic vessel harvesters. Moreover, any single one component improvement described herein may be incorporated into any existing vessel harvesting system, again, unless the structures or functions are mutually exclusive.

Prior Endoscopic Vessel Harvesting System

The three primary components of an exemplary prior art vessel harvesting system are seen in the separate views ofFIGS. 1A-1C. This particular system is representative of one type of prior art vessel harvesting systems, and many of the improvements described herein will be described with direct reference to it. However, as will be understood by one of skill in the art, any one single improvement to a subcomponent of the vessel harvesting system may, in most cases, be incorporated into other such systems. More important, if any single improvement(s) are independently claimed, the application should not be construed as being limited to the system shown inFIGS. 1A-1C. That said, the exemplary prior art system includes an endoscopic dissector20inFIG. 1A, an endoscopic vessel harvester22seen inFIG. 1B, and an access trocar24seen inFIG. 1C.

The endoscopic dissector20includes an elongated tube or cannula30extending between a distal conical tip32and a proximal handle34. A bell-shaped port36on a proximal end of the handle34receives a conventional medical endoscope38which may be fitted with an optical connector40. Although not shown, the elongated shaft of the endoscope38extends through the entire length of the dissector20such that a viewing end terminates in proximity to the conical tip32, which is typically transparent. It should be understood that vessel harvesting systems are typically disposable and are packaged and sold separately from the endoscope which is typically reused. In all cases, however, these endoscopic vessel harvesting systems are designed to accommodate and function with a conventional endoscope, and are therefore claimed accordingly.

Tubing42supplies insufflation gas into an input within the handle34that opens into an elongated passage within the cannula30in communication with a distal egress port44. In use, the user inserts the distal tip32and cannula30into the body through an access device such as the trocar24seen inFIG. 1C, and into proximity with a target vessel, such as the saphenous vein in the leg. By pushing the conical tip32along the target vessel under endoscopic vision, the user is able to grossly dissect connecting tissue from around the vessel. Insufflation gas forced out of the distal port44pressurizes the dissected cavity and facilitates viewing and further dissection. After a desired length of target vessel has been separated from surrounding tissue, the dissector20is removed from the patient.

Subsequent to vessel dissection, the vessel harvester22is inserted through the access trocar24and into the dissected cavity around the target vessel. The vessel harvester22also includes an elongated tube or cannula50extending between an open distal end52and a proximal handle54. Again, a conventional endoscope38snaps into a proximal bell-shaped port56that includes an axial slot58to receive the perpendicularly-extending optical connector40. As with the dissector20, the elongated shaft of the endoscope passes entirely through the cannula50and terminates at a viewing end or objective lens60close to the open distal end52.

The harvester22further includes tools to sever side branches from the target vessel while simultaneously closing them off to prevent bleeding. For instance, a holding tool62may be used to manipulate the target vessel so that a severing and sealing tool64has clear access to the various side branches. Each of these tools may be manipulated by controls66provided in the handle54. One of the controls66is a thumb lever thumb lever that connects to a wiper blade at the distal end of the elongated cannula50for clearing the objective lens60of the endoscope. To facilitate the harvesting operation, an insufflation system including tubing68may be provided so that gas may be passed out the open distal end52of the cannula50. Also, electrical wires70connect to the handle54to provide energy for a coagulator incorporated into the severing and sealing tool64. It should be understood that as generally described so far, these components of the prior art vessel harvesting system are well known in the art, the present application dealing with improvements thereto.

The third main component of the harvesting system is the access trocar24seen inFIG. 1C. In this embodiment, the trocar includes a main access tube70having an angled distal tip72and a proximal housing74. Although not shown, an inner seal such as a diaphragm seal may be incorporated within the housing74to provide a gas-tight interface with the dissector20or harvester22that passes through the trocar24. The main access tube70extends through an incision in the body and a spring-biased clip76secures the trocar thereto.

Improvements to Dissection Function

FIG. 2Ashows the distal end of an alternative vessel dissector80of the present invention including an articulated dissecting tip82. The tip82connects to an elongated cannula84via an accordion-like flexible interface or sleeve86. A pair of pull wires88extends through the cannula84and attaches to points on opposite sides of the dissecting tip82. By manipulating the pull wires88, the user can angle the generally conical tip82in either direction within a plane, relative to the axis of the elongated cannula. By rotating the entire cannula84, a full 360° range of tip movement is obtained. The flexible sleeve86acts like a compression spring and tends to revert the tip82back to an axial alignment when pull forces are released.

FIG. 2Bis another alternative vessel dissector90having an articulated dissecting tip92. As with the dissector80, the tip92connects to the distal end of an elongated cannula94in a manner that enables it to be angled within a plane with respect to the cannula. In this embodiment, a spherical bearing surface96provides the interface between the tip92and cannula94. A pair of pull wires98connected to the tip92enables the user to angle the tip as desired. A flexible spine of sorts (not shown) may also be provided to provide a force that restores the axial alignment of the tip92when pull forces are released.

FIG. 3is a side view schematically illustrating the possible path of bodily fluids into an existing endoscopic vessel dissector100that includes one or more ports102near its distal end for insufflation of gas such as CO2. That is, a passage is provided within the cannula of the vessel dissector100to deliver gas from a proximal end thereof to the ports112. If fluid is permitted to enter the cannula through the insufflation ports102, it may eventually migrate to within the transparent distal tip and interfere with endoscopic viewing therefrom.

FIG. 4Aillustrates the distal end of an alternative vessel dissector110of the present invention including a small fluid barrier112extending proximally from the distal tip114for inhibiting ingress of bodily fluids into insufflation ports116formed in the side of the dissector cannula. The fluid barrier112in this embodiment comprises a tubular shield which can be formed from relatively thin medical plastics. The fluid barrier112is desirably flexible enough to permit gas egress from the ports116while preventing liquid or solid ingress, much like a reed valve.

FIG. 4Bshows an alternative vessel dissector120having an alternative fluid barrier122surrounding the distal end thereof near the distal tip124. The fluid barrier122in this embodiment comprises a tubular porous membrane that covers the gas insufflation ports126in the side of the dissector cannula so that liquid or solid is prevented from entering though gas can exit. The membrane122is any medically suitable gas-permeable liquid-resistant barrier such as ePTFE made by W. L. Gore.

In a further embodiment, the port from which insufflation gas is expelled is located not on the cannula body, but on a dissecting tip secured to the distal end thereof. For example, the dissecting tips82,92ofFIG. 2A/2B may feature a port from which gas escapes into the surrounding tissue cavity. Alternatively, a transparent conical tip32as inFIG. 1Amay have a port formed at the distal apex. In each of these alternatives, a fluid barrier desirably fills or covers the port to prevent liquid or solid ingress, while permitting gas egress as shown inFIGS. 4C-4D. Forming the port on the dissecting tip may be advantageous because the gas is expelled farther distally, and a selection of different tips as desired may be coupled to a generic cannula.

FIG. 5Ais a schematic side view of an endoscopic vessel dissector100of the prior art passing through body tissue104. Insufflation assists in maintaining the dissected cavity or tunnel, though there may be friction between tissue and the following cannula106because of its equal size relative to the dissecting tip108.

To help facilitate passage of the cannula through tissue, an endoscopic vessel dissector130of the present invention seen inFIG. 5Bincludes a narrowed cannula132, at least adjacent to a dissecting tip134and desirably along its entire length. The cannula132has a diameter that is smaller than the diameter of the dissecting tip134, and preferably between about 50-75% of the diameter of the dissecting tip134. A narrow cannula proximal to the dissecting tip improves maneuverability and reduces shaft friction within the dissected tunnel.

FIGS. 6A-6Care longitudinal sectional views through alternative transparent tips for use with endoscopic vessel dissectors of the present invention. Prior transparent dissection tips, such as seen in U.S. Pat. No. 5,980,549 to Chin, et al., include a hollow interior with a front wall tapering to a sharp point, or apex. The outer profile retains a more rounded, blunt configuration for atraumatic dissection. The sharp inner apex helps remove a spot of distortion in the center of the visual field.

In addition to distortion, some conical blunt dissection tips made of clear materials reflect light from the light fibers back to the objective lens of the endoscope. To address this need, a generally conical dissection tip140inFIG. 6Aincludes an inner tapering surface142that terminates at its distal end in a line144so as to form an elongated inner corner, or reverse wedge shape. This configuration works to reduce glare back to the objective lens of the endoscope. InFIG. 6B, a dissection tip146includes an inner surface that tapers downward toward its distal end and terminates in a flat surface148set at an angle from the axis of the tip146. In this case, incident light is reflected away from the objective lens, which is typically placed along or near the axis of the tip or dissector cannula. Finally,FIG. 6Cillustrates a dissection tip150having an internal taper that ends at its distal-most extent in a backward wedge. This shape helps deflect light from the fibers outward as opposed to directly backward, thus reducing glare or reflection. All of these shapes have the effect of reducing incident glare from the light fibers back to the objective lens of the endoscope, thus improving the user's view.

A common technique for vessel harvesting is to provide a separate vessel dissector and vessel harvester, with the devices being inserted one at a time in the body, typically through the access trocar. Such is the configuration of the system inFIGS. 1A-1C. However, it is conceivable that the dissecting and harvesting functions can be combined into a single device to save time. For instance,FIG. 7schematically illustrates the distal end of an integrated endoscopic vessel dissector/harvester160of the present invention having a blunt dissecting tip162with apertures or recesses for the harvesting tools. More particularly, a vessel holding tool164includes a tapered outer surface to match the dissection tip162and is stationed within a recess therein. Likewise, a vessel severing tool166having an outer surface that conforms to the dissection tip162is retracted into a similar recess. Each of the vessel holding tool164and vessel severing tool166docks into recesses in the dissecting tip and has an exterior shape that conforms to the conical exterior of the dissecting tip so as to match its shape. The distal end of an endoscope168is seen extending within the clear dissection tip162. For dissection, the tools164,166are retracted to conform to the conical tip162. Then, by manipulating the vessel holding tool164and vessel severing tool166(such as by axial and rotational movement), selected side branches or primary vessels may be severed and sealed immediately after a section of tunnel around the primary vessel has been dissected. The vessel dissector/harvester160is therefore advanced in stages along the primary vessel performing both dissection and side branch management.

Another configuration that is contemplated to combine the functions of the tissue dissector and vessel harvester is to provide a dissection tip that can be detached from a cannula which contains harvesting tools. For example, any of the conical tips seen inFIGS. 6A-6Cmay be separable from a cannula that houses any of the harvesting tools described below. With such a system the user may alternate between dissection in ligation-transection as desired. Furthermore, such a detachable conical tip may include an opening therethrough to permit CO2insufflation. Following dissection, the cone is detached and insufflation may continue through the open end of the cannula. Another alternative is to provide a tether connecting the removable conical tip to the cannula. In this way, the tip can be detached the remains in close proximity to the distal end of the cannula for reattachment if desired.

Occasionally, fatty or other tissue sticks to the outside of the conical dissecting tip and prevents clear visualization therethrough.FIG. 8is a perspective view of an endoscopic vessel dissector170of the present invention having a wiper blade or finger172for clearing the distal dissecting tip174of tissue. In this embodiment, the wiper blade172pivots about an axis176at the beginning of the dissecting tip174, or end of the cannula178. An actuating rod180controlled by a thumb lever182connects to the wiper blade172and permits the user to alternately retract and engage the blade with the exterior of the dissecting tip174. The tip174rotates about the axis of the cannula178when the user turns a knob184at the proximal end of the device. The wiper blade172may be rigid or include a resilient scraper much like a vehicle wiper blade. Various structural details of this arrangement are left out but are well within those skilled in the art of medical device design. Likewise, alternative arrangements are contemplated, such as those shown inFIGS. 9 and 10.

FIGS. 9 and 10are perspective views of the distal tip of two alternative endoscopic vessel dissectors of the present invention both having tip wiping capabilities. The dissector190inFIG. 9is similar to the dissector170ofFIG. 8in that it includes a wiper blade or finger192for clearing tissue from the conical dissecting tip194. Instead of the tip rotating, however, the blade192swivels about the axis of the device, such as through its connection with a rotating outer sleeve or shaft196of the elongated device. Again, details of the actuation of the shaft196are not shown, but are easily borrowed or surmised from existing devices.FIG. 10illustrates a dissector200fitted with an O-ring wiper202over its conical dissecting tip. An actuation rod204displaces the O-ring wiper202longitudinally to wipe clean the dissecting tip. The O-ring wiper202may be formed as a loosely-wound metal or plastic spiral to facilitate expansion and contraction around the tip. Of course, there are numerous other configurations of wipers that may be displaced over the dissecting tip, the present application only illustrating an exemplary selection.

A further alternative to the tip wiping devices inFIGS. 8-10is to add an energized cutting electrode to the wiper blade to remove tissue via ablation. That is, instead of or in addition to an inert rigid or resilient blade, a wire or bar electrode may be incorporated to enable clearing of more stubborn tissue via electrocautery. Although a specific structure is not shown, the reader will understand that any of the wiper elements shown inFIGS. 8-10may represent such an energized wiper.

Still further, any of the conical tips illustrated herein, including the simple prior art tip seen inFIG. 5A, may be fitted with a system for clearing adhered tissue using fluid expelled from the cannula. For example, an annular opening or a series of separate circumferentially-spaced openings may be provided between the conical tip and cannula, and streams of saline expelled from the openings to knock tissue off the tip. Saline is particularly suitable, although other fluids such as jets of CO2gas maybe used. The design intent would be to port the fluid so that it flowed distally along the surface of the cone using the Coanda effect in which a stream of fluid or gas will tend to hug a convex contour when directed at a tangent to that surface.

Improvements to Vessel Holding Function

Once the target vessel has been exposed, such as with dissection along its length, endoscopic vessel harvesting involves passing an elongated device under visualization along the vessel to sever and seal side branches. As mentioned above, numerous such systems are currently available, including the system seen inFIG. 1A-1C. In that system, a vessel holding tool manipulates the target vessel such that the side branches are positioned in front of a severing and sealing tool. It is important to present both the side branch and target vessel clearly so that the user does not accidentally cut the target vessel instead of the side branch. Also, it is desirable to retract the target vessel so that the side branch can be cauterized as far away from the target vessel as possible, to minimize risk of damage to the vessel from the cautery tool (thermal spread).

FIGS. 11A and 11Bare schematic side views of an endoscopic vessel harvester of the prior art showing a vessel holding tool210and a complementary severing tool212axially extended from the distal end of a cannula214. The holding tool210typically has a hook or other capturing feature for holding a primary vessel216. As the device advances, side branches218are encountered and the system is manipulated to place them in line with the severing tool212. There are certain drawbacks to this arrangement, in particular the linear extension of the tools210,212, rendering them somewhat awkward to maneuver for proper positioning of the side branches218.

FIGS. 12A and 12Bare schematic side views of an endoscopic vessel harvester220of the present invention showing a vessel holding tool222and a severing tool224extended from the distal end of a cannula226. To more easily accomplish straightening of the side branches218in line with the severing tool224, the vessel holding tool222translates laterally. As seen inFIG. 12B, the effect of angling the holding tool222radially outward is to facilitate advancement of the tool along the primary vessel216as well as to straighten the side branch218for more effective cutting with the severing tool224. A comparison ofFIGS. 11A and 12Ashows the increase in spacing between the holding and severing tools, which exposes a greater length of side branch. The holding tool222can be displaced laterally as shown by simply mounting it on a curved or bent actuation rod, or via an angling mechanism, not shown. In the case of a curved or bent support rod, the rod may be flexible so as to retract within the cannula, and the farther the tool22extends the greater the lateral displacement. In general, the vessel holding tool222includes a support rod that extends through the elongated cannula226and which is angled or is configured to angle laterally at a location close to the distal end of the tool.

FIG. 13is a schematic side view of an alternative endoscopic vessel harvester230of the present invention wherein a vessel holding tool232includes a tip angled toward the vessel severing tool234. In this way, the holding tool232can position the primary vessel216in line with the severing tool234. Ultimately, the primary vessel216will be severed at at least one end after having been separated from its connecting side branches. The holding tool232facilitates this step. It is conceivable that the harvesters220and230can be combined such that the vessel holding tool may alternately be angled away from the severing tool, as seen inFIG. 12A, and toward the severing tool, as seen inFIG. 13. In other words, an articulating vessel holding tool may be provided that has a support rod extending through the cannula which is configured to articulate laterally at a location close to the distal end of the tool and enable different angulations depending on the situation.

FIGS. 14A-14Care several views of the transverse displacement of an alternative vessel holding tool240upon extension from the cannula242of an endoscopic vessel harvester of the present invention. In this embodiment, the holding tool240mounts on the end of an elastic wireform244having a bend246. When retracted, the wireform244straightens within the delivery channel248. As the tool is extended, the bend246eventually clears the end of the channel248causing lateral displacement of the holding tool240.

Another way to enable angling of the distal end of the vessel holding tool is to provide a flexible support rod or wireform and surround it with a rigid hypotube. Both structures may longitudinally extend from the mouth of the cannula, and then retraction of the hypotube from around the wireform angles the vessel holding tool. In this embodiment, greater maneuverability of the vessel holding tube is provided as it may be angled at various axial locations rather than immediately as it exits the cannula.

In a further advantageous feature, the vessel hook of the vessel holding tool may incorporate a tapered blunt distal dissecting surface for blunt dissection of tissue. The term “blunt” surface in this context means one without sharp points or corners and with some degree of taper to facilitate division or partition of tissue planes. For example, the conical tips described herein are considered blunt, and as a rule do not have sharp points. The more rectilinear tissue holders of the prior art, however, are too blunt and not well suited for tissue dissection.

It is very important to minimize obstructions in the field of view—the more the device blocks the user's view of the tissue, the greater the risk of avulsions and cautery mistakes.FIGS. 15A-15Bare side and perspective views of an alternative vessel holding tool250of the present invention that has a lower profile than previous tools and thus provides greater visibility of its operation. With reference back toFIG. 1B, the holding tool62of the prior art includes two rods or supports that extend distally from the cannula50. These two rods present solid viewing obstacles interposed between the endoscope objective lens and the actual vessel holding operation. Desirably these obstacles are minimized.

In one such lower profile holder, the vessel holding tool250has a single main rod or support252extending distally from the distal end of the cannula254that carries a vessel hook256. The hook256is shaped to partially surround the primary vessel and manipulate it to present a side branch to an associated vessel severing tool (not shown).FIG. 15Billustrates the extension of a locking member258, which can be, for example, a concentric or telescoping extension of the main rod252. The hook256may be substantially C-shaped so as to partially surround the vessel, and the extension of the locking member258closes the remaining open side so that the vessel is completely surrounded and captured therein. In this way, a vessel may be securely held by the holding tool250without risk of dislodgment yet the view from the objective lens is maximized by removal of one of the support rods.

FIGS. 16A-16Billustrate a further vessel holding tool260of the present invention formed of thin wire, also to reduce its profile, reduce impediments to endoscopic viewing, and thus increase visibility and accuracy of the operation. The tool260extends from the cannula262and includes a hook portion264formed of a single wire, and a translating locking member266formed of another wire or pin. Again, with the locking member266extended the holding tool260completely encloses the vessel for manipulation and severing. Although there are two support rods extending from the cannula, they are extremely thin and present a minimum viewing obstacle to the objective lens. Desirably, the holding tool260is formed of metal or plastic wires having a thickness of between about 0.5 mm and 1.0 mm.

FIG. 17Ais a partial sectional view of a vessel holding tool270of the present invention incorporating a mechanism for preventing vessel avulsion. These types of vessel holding tools are used to hook the primary vessel and move down its length, occasionally stopping to sever side branches. If the tool is moved too fast or too hard when a side branch is reached, damage can occur. The tool270includes a hook portion272that is mounted on the end of a displacement rod274extending from the cannula276. Within the cannula276, the rod274passes through a friction collar278that acts as a damped slip mechanism between the hook portion272and the cannula276. That is, if the hook portion272experiences resistance as it travels down the length of the primary vessel, further movement of the cannula276will not further pull or push on the vessel, but instead will cause damped relative movement between the cannula and the hook portion.

In a similar manner,FIG. 17Bshows a vessel holding tool280with a hook portion282mounted on a displacement rod284extending from a cannula286. A slip mechanism288, in this case a piston/cylinder/spring arrangement, permits damped relative tool/cannula movement in case the hook portion catches on any body structure and generates a reaction force in the displacement rod284in opposition to movement of the cannula286. Of course, the two examples ofFIGS. 17A and 17Bare merely exemplary and other clutch mechanisms performing a similar function can be substituted.

Finally,FIG. 18illustrates still another vessel holding tool290of the present invention having an enlarged locking member292for better positioning of the vessel294. That is, the vessel294is first retained within the hook portion296then a locking member292is axially extended to capture it. Earlier locking members were thin rods or pins that left a relatively large space within the mouth of the hook portion296, and thus especially smaller vessels could easily move around. In this embodiment, the locking member292is shaped as a large wedge that limits the space in which the vessel294is held and thus increases its stability prior to the side branch severing operation. In terms of relative size, the locking member292when extended desirably reduces the space within the mouth of the hook portion296by about 50%. The tapered leading edge helps prevent pinching of the vessel as the locking member292extends.

Improvements to Vessel Severing Function

Numerous instruments are known which coagulate, seal, join, or cut tissue, and which are suitable, for example, for severing a target vessel from surrounding side branches and securing the separated ends to stanch bleeding. Such devices typically comprise a pair of tweezers, jaws or forceps that grasp onto and hold tissue therebetween. The devices may operate with a heating element in contact with the tissue, with an ultrasonic heater that employs frictional heating of the tissue, or with a mono- or bi-polar electrode heating system that passes current through the tissue such that the tissue is heated by virtue of its own electrical resistance. The devices heat the tissue to temperatures such that the tissue is either “cut” or “sealed”, as follows. When tissue is heated in excess of 100° Celsius, the tissue disposed between the tweezers, jaws or forceps will be broken down and is thus, “cut”. However, when the tissue is heated to temperatures between 50° to 90° Celsius, the tissue will instead simply “seal” or “weld” to adjacent tissue. Monopolar and bipolar probes, forceps or scissors use high frequency electrical current that passes through the tissue to be coagulated. The current passing through the tissue causes the tissue to be heated, resulting in coagulation of tissue proteins. In the monopolar variety of these instruments, the current leaves the electrode and after passing through the tissue, returns to the generator by means of a “ground plate” which is attached or connected to a distant part of the patient's body. In a bipolar version of such an electro-surgical instrument, the electric current passes between two electrodes with the tissue being placed or held between the two electrodes as in the “Kleppinger bipolar forceps” used for occlusion of Fallopian tubes. A new development in this area is the “Tripolar” instrument marketed by Cabot and Circon-ACMI which incorporates a mechanical cutting element in addition to monopolar coagulating electrodes. A similar combined sealing and mechanical cutting device may also be known as a tissue “bisector,” which merges the terms bipolar cautery and dissector. One tissue bisector is packaged for sale as an element of the VASOVIEW® 6 vessel harvesting systems by Guidant Corporation of Santa Clara, Calif. In ultrasonic tissue heaters, a very high frequency (ultrasonic) vibrating element or rod is held in contact with the tissue. The rapid vibrations generate heat causing the proteins in the tissue to become coagulated. Conductive tissue welders usually include jaws that clamp tissue therebetween, one or both of which are resistively heated. In this type of instrument, no electrical current passes through the tissue, as is the case for monopolar or bipolar cautery.

It should be understood that any of these prior instruments for severing and/or sealing vessels, or those described below, may be combined with the various components of the vessel harvesting systems described herein. It should also be understood that various configurations of monopolar, bipolar, or other type of electrodes may be provided on the vessel severing/sealing tools described below. Those of skill in the art will understand that the particular shape and size of the electrodes, and their arrangement with respect to other electrodes, will dictate the power requirements and operational constraints. Further, some embodiments described herein may work better with one or other type of electrodes or heating elements, though such optimal permutations will not be exhaustively described.

One important function of any severing tool is to manage vessels of different sizes without extra effort on the part of the user. This is particularly important for bipolar cautery tools which must realize good tissue contact with both electrodes for optimum performance. For fixed electrodes (such as the “bisector” described above), small vessels are more difficult to cauterize; users are taught to position the vessel between the bisector electrodes, and then to rotate the bisector to ensure good contact with both electrodes. Merely decreasing the distance between the electrodes for better contact may prevent use on larger vessels. Moveable electrodes, or jaws, are on solution but require some additional effort to avoid clamping too hard on the vessel, which may result in damage thereto.

FIGS. 19A and 19Bare schematic views of an alternative vessel severing tool300of the present invention having two wire electrodes302overlapping across a large gap G defined by a mouth for receiving a vessel. In contrast with some earlier devices, the gap G is large enough to receive both the side branches and the primary vessel, preferably between about 4.0 mm and 6.0 mm, more preferably about 6.0 mm. The wire electrodes302that overlap in a crossing pattern across the gap G are resilient and flex to automatically accommodate widely varying sizes of vessel. In this context “accommodate” means to contact opposite sides of the vessel. This is especially important to ensure good contact with very small vessels. The vessel severing tool300desirably accommodates vessels having diameters that range from between 0.5 mm and 6.0 mm. In a variation of the embodiment ofFIGS. 19A and 19B, a vessel severing tool has a mouth defined by facing vessel contacts that flex apart upon receiving a vessel therebetween, though the contacts may not be electrodes. Any cutting tool may be combined with a variably-sized mouth to secure different sized vessels.

Desirably, the wire electrodes are made of stainless steel and have a wire thickness of between about 0.5 mm and 1.0 mm so that they easily flex to permit a vessel to move farther into the gap than if they were more rigid and thus ensure good current contact with the vessel. Also, as seen inFIG. 19B, the wire electrodes302are set at different radial distances from the central axis of the tool out of contact with each other, thus providing the separation needed for bipolar coagulation. One distinct advantage of the vessel severing tool300over prior designs is its ability to automatically accommodate varying sizes of vessel. That is tools having movable jaws, for example, can adapt to various vessel diameters but only upon careful user manipulation. The tool300thus speeds up the entire vessel harvesting operation, which may involve severance of numerous vessels.

FIG. 20is a side view of an alternative vessel severing tool310of the present invention having a stepped vessel-receiving mouth312. The stepped shape of the mouth312accommodates a wider range of vessel sizes while ensuring good contact with tissue cautery electrodes (not shown) provided, for example, on opposite sides of the mouth. In contrast to a fixed V-shaped gap, the stair-stepped shape of the mouth312presents several progressively smaller intermediate gaps with generally parallel sides that provide regions of constant width surface contact with the vessel. Also, the step to the next smaller intermediate gap contacts the vessel. This “bracketing” of the vessel helps ensure a good seal without the risk of excessive pinching. The vessel severing tool300desirably accommodates vessels having diameters that range from between 0.5 mm and 6.0 mm. In one embodiment, the mouth312of the vessel severing tool300defines intermediate gaps having widths in decreasing increments of 1.0 mm, for example 6-5-4 mm, or 5-4-3 mm.

Although immovable severing/sealing tools may prove suitable in certain applications, often it is desirable to apply certain amount of pressure to the vessel with movable jaws, for example.FIGS. 21A-21Billustrate a vessel severing tool320of the present invention having jaws322that are resiliently biased away from one another and which can be partially closed. The jaws322may carry bipolar or monopolar electrodes. A pull wire or control rod324connects to a closure ring326and enables axial displacement thereof for closing the jaws322, as seen inFIG. 21B. Visualization of the severing/sealing operation then enables the user to vary the extent of closure of the jaws322, and thus the magnitude of pressure applied. The jaws322cannot completely close and have a minimum gap therebetween as see inFIG. 21Bof between about 0.5 mm and 1.0 mm. This minimum is calibrated so that the tool320accommodates even the smallest expected vessels, yet excessive clamping of even much larger vessels is reduced because there is no contact between the jaws322.

FIG. 22is a side view of a vessel severing tool330having stationery jaws332and rotary blades334incorporated thereon. The blades334may be connected to electric power and function as cutting electrodes, or may be inert knife blades, that work in conjunction with separate sealing electrodes (not shown) provided on the jaws332. This configuration removes the need for providing electrodes that perform dual severing and sealing functions, which frees the designer to optimize the sealing electrodes.

FIGS. 23A-23Bare two side views of a vessel severing tool340having a movable blade342that desirably works in cooperation with electrodes (not shown) that seal the cut vessel. A control rod344connects to displace the blade342toward an anvil346provided on a hook portion348of the tool340. The blade342and cooperating anvil346are slightly angled as shown to sever the vessel with a shearing action. A mechanical cutter such as this may be desirable in contrast to electrocautery transection which can be time-consuming, may inflict thermal damage on the tissue, and may not be entirely effective.

FIG. 24schematically illustrates a vessel severing tool350having a system for clearing tissue therefrom using gas jets. Occasionally, the repeated application of heat or electricity to tissue creates sticking or burning of the tissue to the electrodes. One means to resolve this problem is to provide tubing352extending adjacent a severing/sealing tool354. The tubing352terminates close to the electrodes or cutting blades of the tool354and jets of gas such as CO2may be expelled from the open ends or from special nozzles to knock tissue off the tool. CO2is particularly suitable because it is already used for insufflation of the body cavity, although other fluids such as saline may also be used.

FIGS. 25A-25Bare front and top section views, respectively, of an alternative vessel severing tool360capable of translating transversely as well as longitudinally. An electrode-carrying member362translates circumferentially within an arcuate slot364, and may be actuated by a control rod366. This arrangement greatly enhances the maneuverability of the tool and consequently the options for the user.

InFIG. 26, a severing/sealing tool370shown from its front end within an insufflated tunnel372includes a cannula having a pair of partial tubular vessel shields374extending therefrom around a primary vessel376. The gaps between the shields374accommodate side branches378from the primary vessel376. A tubular cutting element380that may be axially displaced from the cannula surrounds the shields374. The user positions the shields around a vessel376with the side branches378as shown, and then advances the cutting element380. The shields374protect the vessel376and ensure adequate stump length of the transected branches378. The cutting element380may be a tubular knife blade or an electrode designed to cut.

FIGS. 27A-27Bare side and top views of a vessel severing/sealing tool400that incorporates several moving parts. The tool400includes a pair of fork-shaped electrodes402spaced laterally apart so as to create a gap within which moves a severing blade404. A vessel capturing mandible406also moves within the gap between the electrodes402. In use, a vessel408is seen positioned within the tines of the fork-shaped electrodes402and prior to capture by the mandible406. The mandible406has a serrated distal finger to securely capture the target vessel within the tines. Upward movement of the mandible traps the vessel408at which time energy may be applied by the electrodes402to begin the coagulation process. Subsequently, the blade404actuates downward and severs the vessel408. Mechanisms for moving both the blade404and mandible406are not shown, although both have angled or arcuate proximal surfaces that can be utilized to cam against a delivery cannula and displace the elements toward one another upon their proximal retraction using a control rod, for example.

FIGS. 28A-28Bare two schematic views of a vessel severing/sealing tool420incorporating a side-opening cutter/sealer422. In the enlarged view ofFIG. 28B, the cutter422comprises an upper electrode424and a lower electrode426separated across a slot428. The upper and lower electrodes424,426may be bipolar, and the slot428may accommodate a knife blade or other such cutting device.FIG. 29is an endoscopic view showing the use of the tool420severing a side branch430from a primary vessel432.

Finally,FIG. 30is a top plan view of an alternative severing tool440which has a first ring-shaped electrode442extending from a cannula structure444, and the second coil-shaped electrode446concentrically arranged around the first electrode.

While the invention has been described in its preferred embodiments, it is to be understood that the words which have been used are words of description and not of limitation. Therefore, changes may be made within the appended claims without departing from the true scope of the invention.