Method and apparatus for photodynamic irradiation

Apparatus for photodynamic irradiation comprising a housing (10), a lamp (16) mounted in the housing and a reflector (18) surrounding the lamp. A filter unit (40) is mounted in the beam path of the lamp and the reflector, and a light outlet (26) in the housing following the filter unit. A dosage device accurately meters the radiant energy delivered by the apparatus to a patient.

FIELD OF THE INVENTION 
The present invention relates to an Apparatus and Method for Photodynamic 
Irradiation and more specifically to improvements facilitating delivery of 
precise measured dosages of radiant energy to a patient. 
BACKGROUND OF THE INVENTION 
Photodynamic Irradiation devices are not new per se. Patients are exposed 
to photodynamic radiation for therapeutic purposes. A common drawback in 
devices of this type presently known is that it is not easy to deliver 
precisely the desired dose of radiant energy to the patients. 
SUMMARY OF THE INVENTION 
With the foregoing in mind therefore, it is an object of the present 
invention to provide an improvement in devices of this type which 
facilitates delivery of the exact dose of radiant energy desired and which 
at the same time is easy to use and maintain. These apparatus typically 
comprise a housing, a lamp mounted in the housing, a reflector surrounding 
the lamp, a filter unit mounted in the beam path of the lamp and a light 
outlet in the housing downstream of the filter unit. In accordance with 
the present invention, the system includes a dosage device for accurately 
metering radiant energy delivered by the apparatus to a patient. 
Preferably the dosing device consists of diaphragm unit and the path of 
the beam is controlled by a timer or computer. The diaphragm may be a 
shutter capable of being moved in the path of the beam or it can have 
flaps actuatable by a crank mechanism driven by an electric motor to 
permit the flaps to be swung into the path of the beam. It is also 
possible to use a timer or a computer to control the limit of time the 
lamp is on and to measure the dosage. The use of a diaphragm is preferred 
because the lamp does not have to be turned on or off so frequently and 
can continue to burn while the diaphragm unit is closed. 
In accordance with the another feature of the present invention, it is also 
possible to install a radiation dosimeter directly at the treatment site, 
that is on the patient. The dosimeter can be connected with the 
irradiation system by cable. Accordingly, when the radiation dosimeter 
measures a predetermined amount of radiant energy delivered which can be 
determined in advance, it can actuate the dosage device and thus turn off 
the lamp or block off the energy. 
According to another feature of the present invention, means are provided 
for adjusting the distance between outlet of the apparatus and the 
treatment site and in this way adjust the intensity of the radiation at 
the treatment site which is an important aspect for controlling dosage. 
For example, a distance meter can be used for this purpose. 
There are other features of the invention herein set forth which make it 
possible to use and maintain the apparatus easily and which therefore make 
it possible to deliver the radiant energy reliably and reproducibly.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT 
Referring now to the drawings and, more particularly to FIG. 1 thereof, 
there is shown apparatus in accordance with the present invention 
comprising an elongated housing (10) having opposing sidewalls (10A) and 
(10B) which are generally parallel to a longitudinal axis (12). A socket 
(14) holds a lamp (16) which is surrounded by parabolic reflector (18) to 
guide the light from the lamp (16) in direction parallel to the 
longitudinal axis (12). In a preferred embodiment of the invention, 
reflector (18) is of a diameter or width of approximately 238 cm and of a 
length parallel to longitudinal axis (12) of approximately 26 cm. 
As shown in FIG. 1, the rear or top end of the housing is sealed by cap 
(22) having air outlets (20). A cover cap (24), which has a light outlet 
(26) in the center, fits in the front or bottom end of the housing (10). 
Light outlet (26) is sealed off on its interior side by a removable, 
transparent protective disk (28) to protect the interior components of the 
apparatus. 
A box (30), which consists for the most part of perforated sheet metal and 
which contains two motor-driven blowers (32) (34), arranged one above the 
other, is attached to one side of housing (10). The air drawn in through 
the perforated plates of box (30) in the direction of the arrows shown is 
blown by the blowers through an upper opening (36) near reflector (18) and 
lamp (16) and through a lower opening (38) into the area of a filter unit, 
referred to in general as (40), which is to be described further below. 
Filter unit (40) is designed as a removable rack type system with a 
multi-level rack (42), into which the filter disks (44) required for the 
treatment in question can be inserted parallel to each other. 
Between filter unit (40) and light outlet (26), there is a diaphragm 
device, referred to overall as (46), which is installed in a support wall 
(48) extending transversely across the housing. Diaphragm device (46) is 
also explained in greater detail below. 
One end (52) of a tape measure (54) is mounted so that it can turn inside 
cover cap (24) and can be pulled out through an opening (50) in front 
cover cap (24) of housing (10) to measure the distance between light 
outlet (26) and the treatment site, and can then be pushed back in the 
direction of double arrow (56). Of course, in a somewhat more expensive 
apparatus, the distance can also be measured by means of an electronic 
distance sensor. 
In the rear or top section of housing (10), socket (14) of lamp (16) is 
supported on a focussing device referred to in general as (58). This 
device is explained in greater detail below on the basis of FIGS. 1 and 2. 
First it is to be noted that focussing device (58), lamp (16), reflector 
(18), and air outlets (20) are positioned with respect to each other so 
that as little direct light as possible can pass from the lamp (16) 
through air outlets (20) to the outside. Focussing device (58) has a front 
intermediate plate (60), to which socket (14) of lamp (16) is attached, 
and a rear support plate (62), approximately parallel to the front plate. 
Support plate (62) is attached to a membrane plate (66), only the external 
edge of which is fastened rigidly to the housing. The rear or top side of 
the membrane plate is connected in turn to a cup-like bracket plate (68). 
Between intermediate plate (60) and support plate (62) there is a ball (64) 
positioned on longitudinal axis (12). One side of intermediate plate (60) 
can be adjusted by means of a setscrew (70), mounted in support plate 
(62), whereas the opposite side is held by a spring-loaded pressure screw 
(72). Instead of the one setscrew (70) shown, it is also possible to use 
several setscrews (not shown). By turning setscrew (70), lamp (16) is 
pivoted in the direction of double arrow (74), around an axis 
perpendicular to longitudinal axis (12). A setscrew (76) is also provided 
in bracket plate (68), extending in the longitudinal direction, the 
adjustable end (78) of which is attached to membrane plate (66). By 
actuating setscrew (76), therefore, the center of membrane plate (66) and 
thus support plate (62) attached to it are pushed in the longitudinal 
direction, as a result of which lamp (16) is shifted in the direction of 
double arrow (80). Because of the possibility of these adjustments, the 
lamp can be focussed with extreme accuracy within reflector (18), which is 
mounted rigidly in the housing. 
FIG. 3 shows diaphragm device (46) shown in FIG. 1 on an enlarged scale. 
Diaphragm device (46) has two opaque flaps (82), which, when in the open 
position according to FIG. 3, are parallel to longitudinal axis (12), and 
which can be pivoted around their pivot bearings (86) according to arrows 
(84) into a position (not shown) perpendicular to longitudinal axis (12) 
to block off the beam path of the apparatus. A crank mechanism (90), 
driven by a drive motor (88), pivots flaps (82); the two extreme positions 
are adjusted by means of limit switches (94), actuated by thrust pins 
(92). Drive motor (88) can be connected to a suitable electronic unit of 
the apparatus so that it can pivot flaps (82) under accurate time control. 
FIGS. 4 and 5 show filter unit (40) used in the apparatus according to FIG. 
1 in greater detail. This unit is designed as a standardized filter rack 
system with a rack (42), which can be attached by suitable brackets (98) 
to housing (10). Rack (42) has several parallel filter frames (100), each 
of which has a central opening (102). In addition, strips (104) with a 
roughly Z-shaped profile are attached to diametrically opposite sides of 
each filter frame (100); a filter disk (44) can be inserted into them. 
After insertion, filter disks (44) can be held in place in the insertion 
direction of the disks by retaining knobs (108), which can be attached 
either to filter frame (100) or to Z-strips (104). 
So that all apparatus assemblies inside housing (10) can be maintained 
easily and possibly replaced easily and quickly, a part (110) of the 
housing wall, extending over the entire length of the housing as shown in 
FIG. 6, is attached by means of easily removable screws (112) or other 
removable means of attachment to the rest of housing (10). By removing 
housing part (110), the interior of housing (10) can be easily made 
accessible for the purpose indicated and then easily closed again. 
In a manner not shown in detail, the entire reflector (18) can be divided 
in the longitudinal direction into approximately 40-50 segments, which 
remain edge to edge as they extend from the rear or top end to the front 
or bottom end of the reflector. The facets can in turn be subdivided into 
individual subfacets, which have a slight concave curvature in the 
transverse direction. The overall curvature thus remains parabolic, so 
that the treatment site is subject to radiation of highly uniform 
intensity. 
Even though a particular embodiment of the invention has been illustrated 
and described herein, it is not intended to limit the invention and 
changes and modifications may be made therein within the scope of the 
following claims.