Dosing device for adding a controlled amount of a gas to a fluid

In a dosing device and method for controlled dosing of a first gas into a second gas or liquid membrane which is permeable to the first gas separates the first gas from the second gas or liquid. Dosing of the first gas is performed by controlling diffusion through the membrane. The size of the active diffusion area can be regulated by a barrier which is moveable in relation to the membrane. When the barrier is moved in relation to the membrane, a larger or smaller part of the membrane's diffusion area can be exposed to the second gas or liquid. Alternatively, the membrane's permeability can be controlled or the partial pressure of the first gas can be controlled.

BACKGROUND OF THE INVENTION 
1. Field of the Invention 
The present invention is directed to a dosing device for adding a 
controlled amount of gas to a fluid (i.e., a liquid or another gas), and 
more specifically is directed to a dosing device for adding a controlled 
amount of nitric oxide (NO) to a fluid to be administered to a patient. 
2. Description of the Prior Art 
In very small quantities, NO can have a number of beneficial effects on 
pulmonary function. Doses can range from about 1 ppm of NO up to about 50 
ppm of NO, however, a problem is that NO is inherently hazardous and 
contributes to an increase in the conversion of NO into NO.sub.2 on 
contact with oxygen. NO.sub.2 is a highly toxic gas, even in very low 
concentrations. A number of designs for delivery and monitoring devices 
have been proposed for minimizing the risk to patients receiving NO. 
Monitoring is particularly difficult, since no methods are known for rapid 
and reliable measurement of low concentrations of NO. 
SUMMARY OF THE INVENTION 
An object of the invention is to provide a method and dosing device for 
delivering small amounts of gas, NO in particular, into a breathing gas 
supplied to a patient for medical purposes. 
The above object is achieved in accordance with the principles of the 
present invention in a method and a dosing device wherein the gas to be 
added in a controlled amount to the fluid is separated from the fluid by 
at least one membrane, the membrane having an active diffusion area 
through which the gas must diffuse in order to reach the fluid. Diffusion 
of the gas through the membrane is actively controlled, thereby also 
controlling the amount of the gas which is added to the fluid. 
The use of a material permeable to oxygen for increasing the oxygen content 
of a chamber is known, as described in U.S. Pat. No. 5,158,584 and which 
has a number of tubes arranged in a tube surrounding a chamber. The tubes 
are made of a material more permeable to oxygen than to nitrogen. The ends 
of the tubes are open to ambient air. A fan forces air through the tubes. 
When gas passes the tubes, oxygen diffuses more rapidly than nitrogen 
through the membrane into the chamber. The amount of oxygen in the chamber 
air is accordingly increased somewhat, compared to ordinary air. Air 
enriched with oxygen can then be respirated by a patient. 
Similar systems are also used to oxygenate blood in an artificial lung. 
Blood is then allowed to pass through tubes of similar material, and 
oxygen is supplied to the exterior of the tubes. The oxygen diffuses into 
the blood, and carbon dioxide in the blood diffuses out in the opposite 
direction. This results in a gas exchange like the one occurring in an 
ordinary lung. One such apparatus is described in European Application 0 
048 943. 
Another use for a material permeable to gas is in the dehumidification of 
dehumidification of gases. A moist gas is fed through a system of tubing 
made from a material permeable to moisture. Moisture then diffuses into 
ambient air. The effect can be enhanced if the tubing is enclosed in a 
container through which a dry and hot gas is passed. 
Neither of these known uses of semipermeable materials includes controlled 
dosing of a first gas into a second gas. 
The dosing device according to the invention utilizes active control of 
diffusion. This can be achieved in a number of ways. 
A first technique is to vary the active diffusion area, i.e. the area 
through which the area through which the first gas is to diffuse. In one 
embodiment according to the invention, the membrane is combined with a 
barrier. This barrier is made of a material which is impermeable to the 
first gas. The membrane and the barrier are arranged so they can move in 
relation in relation to each other. A major or minor part of the membrane 
can then be exposed to diffusion. 
A second approach is to vary the membrane's permeability. In one embodiment 
of the dosing device according to the invention, the membrane has a number 
of coatings with varying permeabilities to the first gas. The coatings can 
be arranged so one coating at a time serves as the diffusion area, 
diffusion then depending on the choice of material. One or a number of 
coatings can be applied, in whole or part, to a basic coating in order to 
vary diffusion. 
A third technique is to vary the partial pressure of the first gas, thereby 
causing more molecules to diffuse when the partial pressure rises and 
fewer molecules to diffuse when the partial pressure falls. 
Additional versions can be obtained by combining the above embodiments. 
The dosing device according to the invention is, as described above, 
particularly advantageous for use for dosing NO into a breathing gas. 
Use of a dosing device according to the present invention eliminates the 
need for complicated monitoring. Since diffusion through the membrane is 
physically limited, in relation to the exposure area and relative pressure 
conditions, dosing can be performed with inherent safety since the maximum 
dose is limited. In particular, the concentration of NO in the dosing 
device can be limited so the patient only receives a harmless amount of 
NO, even if the entire diffusion area of the membrane is exposed to 
diffusion into the breathing gas. In principle, monitoring with a 
concentration meter will then be unnecessary.

DESCRIPTION OF THE PREFERRED EMBODIMENTS 
FIG. 1 shows a dosing device 2 intended for use in precision dosing of NO 
to a patient 10. The dosing device 2 is connected to a Y-piece 4 in a 
ventilator system (not shown). A breathing gas is supplied, via an 
inspiratory leg 6 in the Y-piece 4, as the arrow 8 indicates. The 
breathing gas, to which NO has been added, is carried to the patient 10 
through a tracheal tube or in some other known fashion. Gas is carried 
away from the patient via an expiratory leg 12 in the Y-piece 4, as the 
arrow 14 indicates. 
The actual dosing device 2 includes a tube 16 made of a material 
impermeable to NO, such as stainless steel. The tube 16 then serves as a 
barrier means. A membrane tube 18 is movably arranged inside the tube 16. 
The membrane tube 18 is made of a material permeable to NO, such as 
Teflon.RTM.. The membrane tube 18 is provided with support struts, or some 
other structure, to stabilize the tube. The membrane tube 18 can be made 
of a perforated metal tube whose interior is clad with a membrane. This 
gives the membrane tube 18 a stable structure and reduces the risk of 
damage to the membrane. 
With the aid of a manipulator 20, the membrane tube 18 can be slid back and 
forth inside the tube 16, thereby exposing a more or less of the diffusion 
area of the membrane tube 18 to breathing gas in the Y-piece 4. At the 
same time, a source of gas 22 is connected to the interior of the membrane 
tube 18 by a gas tube 24. The gas source 22 contains a gas mixture with a 
specific concentration of NO, e.g. N.sub.2 containing 100 ppm of NO. The 
gas source 22 is suitably regulated so a constant pressure prevails in the 
membrane tube 18. This results in a constant partial pressure gradient 
between NO inside and outside the membrane tube 18. Diffusion, governed 
only by the diffusion area of the membrane tube 18, from the interior of 
the membrane tube 18 into the breathing gas, is then achieved. Dosing is 
regulated by exposing an appropriate amount of the total diffusion area. 
The manipulator 20 and membrane tube 18 can also be devised as a single 
component. 
The manipulator 20 is provided with a scale which designates the active 
diffusion area, i.e. the amount of NO which diffuses into the breathing 
gas. If, for example, 1 ppm of NO is desired, the dosing device 2 is set 
so a 35 corresponding part of the diffusion area of the membrane tube 18 
is exposed inside the inspiratory leg 6 of the Y-piece 4. 
Breathing gas then picks up NO and conveys it down into the lungs of the 
patient 10. 
The end of the membrane tube 18 is fitted with a plug 26 to prevent the 
leakage of NO when the membrane tube 18 in the dosing device 2 is 
completed retracted into the tube 16. The plug is made of stainless steel 
or some other material impermeable to NO. 
FIG. 2 shows a second embodiment in the form of a dosing device 30. The 
dosing device 30 includes a container 32, connected to or integral with a 
tube 34, f or a gas or a liquid. A membrane 36 separates the tube 34 and 
container 32. A dosing gas in the container 32 can be carried by a gas 
flowing in the tube 34, as the arrow 38 shows. 
A plate 40 is slidingly arranged in the container 32, in front of the 
membrane 36, to regulate the amount of dosing gas diffusing through the 
membrane 36. The plate 40, which is made of a material impermeable to the 
gas, can be moved back and forth, as the arrow 42 shows. A larger or 
smaller part of the diffusion area of the membrane 36 is then exposed to 
the gas in the tube 34. 
A source of gas 44 is connected to the container 32 by a gas line 46. 
Constant conditions for the dosing gas in the container 32 can thereby be 
maintained. As in the preceding embodiment, exact regulation can be 
achieved by regulating the diffusion area. Regulation can be manual or 
mechanical. When dosing gases, whose concentrations can be easily 
measured, are used, a feedback regulatory system can be installed for more 
accurate control of the diffusion area of the membrane 36. 
The plate 40 is appropriately located inside the container 32 when a gas 
with a positive pressure in relation to the dosing gas flows in the tube 
34. The membrane is then pressed against the plate 40 and effects a seal. 
If the opposite is the case, i.e., if a there is a positive pressure in 
the container 32 in relation to the gas in the tube 34, the plate 40 
should be appropriately located on the exterior of the membrane 36 and 
container 32. In this embodiment, the plate 40 can also be part of the 
tube 34 to which the container 32 is connected when dosing is to occur. 
In an alternative version of this embodiment, the plate 40 has openings and 
channels leading to a pump. The pump can be connected to the container 32. 
When gas is suctioned through the openings, a suction effect is created 
which presses the membrane 36 again the plate 40. When the plate 40 is 
shifted to a new position, gas is instead pumped out through the openings. 
The membrane 36 is blown away from the plate 40 which can then easily be 
moved to a new position. Position changes can accordingly be made without 
the risk of damage to the membrane caused by adhesion to or friction 
against the surface of the plate 40. 
A third embodiment is shown in FIG. 3. The dosing device 50 operates 
according to the same principle as in the two previously-described 
embodiments, i.e., dosing is controlled by varying the area of a diffusion 
surface. The dosing device 50 has a membrane tube 52 which can be 
connected to a tube 54 for dosing a gas into a carrier gas inside the tube 
54. The carrier gas flows in the direction shown by the arrow 56. The 
membrane tube 52 is connected by a gas line 58 to a source of gas 60. A 
constant dosing gas pressure is maintained inside the membrane tube 52. 
Dosing of the dosing gas can be controlled by inserting a larger or 
smaller part of the membrane tube into the tube 54. 
When necessary, a cowl 62 can arranged around the gas line 58 with a 
gas-tight seal at the junction with the tube 54 to prevent leakage into 
ambient air. A plug 64 is arranged in the end of the membrane tube 52 to 
prevent diffusion of dosing gas when the membrane tube 52 is retracted 
back to the wall of the tube 54. 
FIG. 4 shows a fourth embodiment of the dosing device, designated 70, 
according to the invention. This dosing device 70 utilizes another 
principle for controlling dosing. In this instance, diffusion is 
controlled by varying the rate of diffusion. The dosing device 70 includes 
a container 72 connected to a source of gas 74 containing dosing gas. The 
dosing device 70 is further connected to a tube 78 for dosing gas into a 
carrier gas in the tube 78. The arrow 80 shows the direction of flow of 
the gas in the tube 78. 
A first membrane 82 is connected to the container 72 so as to separate the 
interior of the tube 78 from the interior of the container 72. The first 
membrane 82 is highly permeable to the dosing gas. Inside the first 
membrane 82, a second membrane 84 is arranged so that it can be rolled out 
in front of the first membrane 82. The second membrane 84 is wound onto a 
first roller 88, and the second membrane 84 can be rolled back and forth 
(as shown in FIG. 4) when a first guide pin 94 is actuated. The second 
membrane 84 can be arranged so as to press against the first membrane 82 
(the distance between the membranes 82 and 84 has been exaggerated in FIG. 
4 to illustrate the structure of the dosing device 70). Diffusion can be 
controlled by regulating the unrolling of the second membrane 84. The 
second membrane 84 is somewhat less permeable than the first membrane 82, 
and dosing accordingly decreases as the second membrane 84 is rolled out. 
In a corresponding manner, a third membrane 86 is arranged 35 on a second 
roller 90, and a fourth membrane is arranged on a third roller 92. The 
third membrane 86 is even less permeable to the dosing gas than the second 
membrane 84, so dosing can be further reduced (successively) by rolling 
out increasing amounts of the third membrane 86. This is performed with a 
second guide pin 96. The fourth membrane is appropriately impermeable to 
the dosing gas and can successively reduce dosing down to zero. A third 
guide pin 98 is used to regulate the third roller 92 on which the fourth 
membrane is arranged. 
A fifth embodiment, designated 100, of the invention is shown in FIG. 5. 
The dosing device 100 operates according to yet another principle, 
however, the dosing device 100, like the previous embodiments, is 
connected to a tube 102 for dosing a dosing gas into a carrier gas in the 
tube 102. The carrier gas travels in the direction shown by the arrow 104. 
The dosing device 100 includes a membrane 106 which serves as a part of the 
wall of a tubing system 108. A fan 110 is arranged in the tubing system 
108 to force gas through the tubing system 108, causing gas to be 
continuously exchanged at the membrane 106. A first gas source 112 and a 
second gas source 114 are connected to the tubing system 108. The first 
gas source 112 contains the dosing gas, and the second gas source 114 
contains a diluent gas. The two gas sources 112 and 114 and the fan 110 
are controlled by a control unit 116. 
The partial pressure of the dosing gas can be regulated by mixing dosing 
gas from the first gas source 112 with diluent gas from the second gas 
source 114. Diffusion through the membrane 106 into the carrier gas in the 
tube 102 is governed by the partial pressure of the dosing gas. Diffusion 
and, accordingly, dosing are controlled by regulating the partial pressure 
of the dosing gas in the tubing system 108. 
A continuous flow of dosing gas, corresponding to the quantity diffused, is 
supplied to the tubing system 108 from the first source of gas 112. Since 
dosing gas and diluent gas are circulated in the tubing system 108 by the 
fan 110, the partial pressure of the dosing gas at the membrane 106 is 
accordingly maintained at the desired level. Partial pressure can also be 
quickly changed by changing the amount of dosing gas and/or diluent gas 
supplied. 
There are also other ways of controlling diffusion. FIG. 6 shows part of a 
dosing device which illustrates an additional technique for regulating 
diffusion. In principle, this apparatus is a combination of some 6f the 
above embodiments. A first wheel 120 is mounted on a first hub 122. A 
first membrane 124, a second membrane 126 and a third membrane 128 are 
arranged in the first wheel 120. The three membranes 124, 126 and 128 have 
the same shape and size but differing permeabilities to the dosing gas. 
They are also symmetrically arranged on the first wheel 120. The 
respective spaces between the membranes 124, 126 and 128 have the same 
shape as the membranes 124, 126 and 128. 
A second wheel 130 is arranged to form a gas-tight seal against the first 
wheel 120 via second hub 132. The second wheel 130 is made of a material 
impermeable to the dosing gas. An opening 134 is arranged in the second 
wheel 130. The size and shape of the opening 134 corresponds to that of 
each of the three membranes 124, 126, 128. 
When the second wheel 130 is rotated in relation to the first wheel 120, an 
optional amount of any of the membranes 124,126 or 128 can be exposed as a 
diffusion area for the dosing gas. Rotation can be performed manually or 
mechanically with a step motor or the like. Mechanical regulation can be 
controlled by feedback from a dosing gas concentration meter, located on 
the dosing gas receiver side. 
An additional arrangement for the dosing device according to the invention 
is illustrated in a seventh embodiment, designated 136 in FIG. 7. 
The dosing device 136 has a connector tube 138, designed for connection to 
a flow system for a carrier gas flowing through the connector tube 138, as 
shown by the arrow 140. A membrane 142 separates the interior of the 
connector tube 138 from a chamber 144 to which a dosing gas is supplied 
from a source 146. A valve 148 is arranged near the membrane 142 in the 
chamber 144. The valve 148 is switched between an open position and a 
closed position by a control unit 150 via a control line 152. 
When the valve 148 is in the open position, dosing gas comes into contact 
with the membrane 142 and diffuses through the membrane 142 into the 
carrier gas in the connector tube 138. When the valve 148 is in the closed 
position, the dosing gas is prevented from coming into contact with the 
membrane 142. Diffusion through the membrane 142 therefore can be actively 
controlled by regulating the valve 148 between the open and closed 
positions. Even if the valve 148 should fail and stick in the open 
position, dosing is limited by the diffusion capacity of the membrane 142. 
This makes the dosing device 136 safer than if the valve 148 were used 
without the membrane 142. 
One application for the dosing device 136 is illustrated in FIG. 8 in which 
the dosing device 136 is assumed to be arranged in the inspiratory part of 
a ventilator system. The ventilator system generates breathing impulses, 
FIG. 8 (top) showing a first inspiration 154A, a first expiration 154B, a 
second inspiration 154C and a second expiration 154D. 
At the same time as the inspirations 154A and 154C are in progress, a 
dosing gas, e.g., NO, is supplied in brief pulses 156A-156F. Dosing gas is 
supplied in such a manner that the control device 150 causes the valve 148 
in the dosing device 136 (FIG. 7) to open for a number of brief intervals 
at the start of each inspiration 154A and 154C. Such pulsed dosing allows 
a relatively high concentration of NO (when NO is used) to be supplied in 
the pulses while the total concentration of NO is kept on a lower level 
(total dilution in the entire breathing gas). Transformation of NO into 
NO.sub.2 is simultaneously minimized. 
Numerous versions of the illustrated embodiments can also be easily 
achieved. For example, the membrane 36 in FIG. 2 can enclose the entire 
tube 34, and the disk 40 can be replaced with a tube. A number of tubes 
can be used and moved in different directions to vary the size of the 
exposure area. The material selected for the membrane depends on the gas 
to be dosed. For example, Teflon.RTM. is appropriate for NO, but there are 
numerous alternatives, since NO has a high diffusion capacity in many 
materials. 
The described embodiments can be combined with each other in different 
ways. Dosing gas can be dosed into virtually any kind of container, tube 
or the like. The membrane can be made of materials selectively permeable 
to the dosing gas. In some instances, however, the diffusion of other 
gases in the "opposite direction" may be permissible, but it is most 
important for dosing gas to diffuse in the "right" direction. 
Although only NO is set forth in the above embodiments as the dosing gas, 
any medical gas could, in principle, be used. The dosing device according 
to the invention, however, is especially suitable for applications in 
which the dosing gas and the receiving medium should not come into 
physical contact (e.g., -o prevent over-dosing or to minimize chemical 
reactions). There are numerous applications in the medical field other 
than the dosing of NO, e.g. the dosing of other gaseous medication or 
anesthetic into a breathing gas. 
The container for the dosing gas does not need to be connected to a source 
of gas containing the dosing gas. In instances in which the dosing gas is 
an anesthetic gas, the anesthetic can be in the liquid state in the 
container, and a constant partial pressure for the anesthetic gas is 
maintained at the membrane by controlling the liquid anesthetic's 
temperature. Solid materials which emit a medical gas relatively 
constantly can be used as a source of gas. 
Although modifications and changes may be suggested by those skilled in the 
art, it is the intention of the inventor to embody within the patent 
warranted hereon all changes and modifications as reasonably and properly 
come within the scope of his contribution to the art.