The present invention provides certain substituted-piperazinyl-1,2,4-triazoles which are useful for the treatment of sensitized humans for allergies and anaphylactic reactions.

BACKGROUND OF THE INVENTION 
The present invention relates to novel substituted imidazoles. Most 
particularly, the present invention relates to certain aminoalkyl 
substituted imidazols. The pharmaceutical use and preparation of these 
compounds is described in U.S. Pat. No. 4,338,453, which is expressly 
incorporated herein by reference. 
PRIOR ART 
Various imidazoles are known. These compounds have been described as useful 
for a wide range of uses. Known imidazole compounds include 
1,2,4,5-tetra-substituted imidazoles useful as antitumor, antiviral, 
antiinflammatory agent agents, and as protective agents against cerebral 
anoxia or hypoxia such as are described in British Pat. No. 2,016,011 
(abstracted in Derwent Farmdoc CPI No. 68606B/38), French Pat. No. 
2,132,632 (abstracted in Derwent Farmdoc CPI No. 10105U-B), U.S. Pat. No. 
3,651,080, and Belgian Pat. No. 810,117 (abstracted in Farmdoc CPI No. 
41717V/23); 1-substituted imidazoles for use in treating inflammation, 
hypertension, thrombosis and asthma such as described in Japanese Patent 
Application No. 109974 (abstracted in Derwent Farmdoc CPI No. 72897B/40); 
1,2-di-substituted-4-haloimidazoles-5-acetic acid derivatives for use as 
diuretics and hypotensives, as described in U.S. Pat. No. 4,207,324; and 
1,4,5-trisubstituted imidazoles useful as antiallergic and hypotensive 
agents such as described in British Pat. No. 1,134,580. U.S. Pat. No. 
3,505,350 discloses certain mercapto imidazole derivatives which are 
useful an antiinflammatory agents. 
SUMMARY OF THE INVENTION 
The present invention particularly provides a compound according to Formula 
I 
##STR1## 
or a pharmacologically acceptable salt thereof, wherein X.sub.1 is 
(a) .dbd.CH--; or 
(b) .dbd.C(CH.sub.3)--; 
wherein m is zero, one, 2 or 3; 
wherein n is zero, one or 2, 
wherein R.sub.1 is: 
(a) 1-piperidinyl substituted at the 3 or 4 position by R.sub.15, wherein 
R.sub.15 is defined as below; 
(b) --N(CH.sub.3)--(CH.sub.2).sub.p --R.sub.15, wherein R.sub.15 and p are 
as defined below; or 
(c) --NH--(CH.sub.2).sub.p --R.sub.15, wherein p is 1, 2, or 3 and R.sub.15 
is as defined below; 
wherein R.sub.4 is: 
(a) hydrogen; 
(b) alkyl of one to three carbon atoms, inclusive; 
(c) R.sub.54 OCH.sub.2 --, wherein R.sub.54 is defined below; 
(d) --CH(R.sub.35)(OH); or 
(e) --R.sub.35 ; 
wherein R.sub.5, R.sub.15, R.sub.25 and R.sub.35 are the same or different 
and are 
(i) 2,3, or 4 pyridinyl, or 
(ii) phenyl substituted by zero to 2 chloro, fluoro, bromo, alkyl of from 
one to 3 carbon atoms, or alkoxy of from one to 3 carbon atoms, or 
(iii) phenyl substituted by one trifluoromethyl and zero to one of the 
previous phenyl substituents, 
wherein R.sub.6 is: 
(a) hydrogen; 
(b) --OR.sub.54 ; 
(c) alkanoyloxy of from one to 3 carbon atoms; or 
(d) alkyl of from one to 3 carbon atoms; with the proviso that when m is 
zero, R.sub.6 does not contain oxygen; 
wherein R.sub.17 is methyl, phenyl, benzyl, or 2-phenylethyl; and 
wherein R.sub.54 is hydrogen or alkyl of one to 3 carbon atoms; 
or an enantiomer (when R.sub.4 is --CH(R.sub.35)OH or when R.sub.6 is not 
hydrogen) or diastereomer (when R.sub.4 is --CH(R.sub.35)OH and R.sub.6 is 
not hydrogen) of such compound.

DESCRIPTION OF THE PREFERRED EMBODIMENTS 
The present invention particularly provides: 
5-Methyl-1-phenyl-N-(2-phenylethyl)-1H-imidazole-ethaneamine; 
N-5-Dimethyl-1-phenyl-N-(2-phenylethyl)-1H-imidazole-ethaneamine; and 
1-(4-Fluorophenyl)-5-methyl-N-(2-phenylethyl)-1H-imidazole-2-ethaneamine.