Stabilized medicament containing cysteinyl derivatives

The invention relates to a stabilized medicament with an amount of active ingredients containing cysteine groups and NSAID compounds, wherein a stabilization of the combination, especially the active ingredients containing the cysteine group, can be conducted with a mixture of at least three anti-oxidative components. The therapeutic and prophylactic use of this medicament stabilized in this manner lies in the field of the prevention and therapy of inflammatory diseases among the fields of medical indications.

PRODUCTION EXAMPLE For the production of effervescent formulations, 50, 100, 300, 400, 500 or 600 mg N-acetylcysteine per dosage unit or the corresponding amount of glutathione; 2, 5, 10, 20, 25, 30 or 50 to 60 mg of (a) the ascorbic acid compound; of (c) one or more carotinoids; of (c) one or more tocopherols and/or of (d) one or more flavonoids such as rutin or esculine, and optionally polyphenols such as caffeic acid (amide) or suitable extracts from citrus fruits or green tea were processed in a customary manner with pharmaceutically acceptable adjuvants to a granulate or powder at the dose of the individual dosages named, wherein, aside from carbonates such as preferably monsodium carbonate, organic acids such as tartaric acid and/or citric acid were preferably used as carbon dioxide developing substances and the final mixture was compacted if required under optional addition of intestinal lubricants, anti-sticking agents and lubricating agents as well as further customary tableting adjuvants if required. In the case of the combination with NSAID, especially with Diclofenac, an amount of 10, 25, 50, 100, 200, 300, 400, 500 or 600 or more mg per dosage unit was preferably processed to a separate granulate or powder depending on the desired strength of activity, activity equivalent and type of activity and/or pharmakinetics, added to the above prepared granulate and compressed to tablets in the customary manner if desired. The given amounts of active ingredient(s) and stabilizer mixture can be respectively halved or also doubled or trebled if required depending on the dosage. The medicinals obtained in this manner are manufactured in the customary manner protected from moisture.