Disposable fluid infusion pumping chamber cassette and drive mechanism thereof

This invention relates to a disposable cassette having a pumping chamber therein and with a controlled positive displacing pump driving apparatus for use with the cassette, for performing intravenous or intra-arterial infusions. More particularly, it pertains to disposable cassettes which include an exposed flexible diaphragm forming one wall of the pump chamber and adapted to be engaged by a plunger or piston member driven and controlled by the driver apparatus to pump fluid through the cassette.

BACKGROUND OF THE INVENTION 
In recent years there has been a increasing use of positive displacement 
fluid infusion pumping devices for delivery fluids intravenously or intra 
arterially to patients in hospitals or other patient care locations. These 
have to a large extent replaced the time honored gravity flow control 
systems, primarily due to their much greater accuracy in delivery rates 
and dosages, the relative sophistication in permitting a flexible and 
controlled feed from multiple liquid sources, and particularly their 
ability to control with precision the amount of dangerous drugs delivered 
to a patient over a given period of time. 
A typical positive displacement infusion pump system includes a pump driver 
device and a disposable cassette. The disposable cassette, which is 
adapted to be used only for a single patient and for one fluid delivery 
cycle, is typically a small plastic unit having an inlet and an outlet 
respectively connected through flexible tubing to the fluid supply 
container and to the patient receiving the infusion. The cassette includes 
a pumping chamber with the flow of fluid through the chamber being 
controlled by a plunger or piston activated in a controlled manner by the 
driver device. For example, the cassette chamber may have one wall thereof 
formed by a flexible diaphragm which is reciprocated by the plunger in the 
driver to cause fluid to flow. The pump driver device includes the plunger 
or piston for controlling the flow of fluid into and out of the pumping 
chamber in the cassette, and it also includes control mechanisms to assure 
that the fluid is delivered to the patient at a pre-set rate, in a 
pre-determined manner, and only for a particular pre-selected time or 
total dosage. The pump driver device may also include pressure sensing and 
other liquid flow monitoring devices as well as valving members for 
opening and closing various passages in the cassette including the inlet 
and outlet passages of the pumping chamber. 
SUMMARY OF THE INVENTION 
The disposable fluid infusion pumping chamber cassette of the present 
invention may be readily and relatively inexpensively manufactured in 
three pieces. The sandwich type construction of the cassette also lends 
itself to a multiplicity of control and monitoring functions including, 
for example, pressure monitoring, air bubble detection monitoring, 
adaption to multiple inputs, and leak detection monitoring, all of which 
functions can be performed without modifying the basic cassette structure. 
Briefly, the cassette of the present invention includes a rigid face member 
and a rigid back member having an elastomeric diaphragm positioned 
therebetween. The back member is configured to provide for the 
transmission of fluid from one end of the cassette to the other and 
includes an enlarged recess portion forming the pumping chamber. The face 
member includes exposed openings opposite the pumping chamber to permit 
the passage of a plunger and opposed openings adjacent the fluid passage 
to permit the selective actuation of valving members therein. Finally, a 
flow control member is mounted upon the face member adjacent the passage 
between the pumping chamber and fluid outlet thereof, which flow control 
member can be utilized to either open the passage to free flow of fluid or 
to block it off completely.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT 
I. Pumping Cassette 
A pumping cassette 10 of the present invention is illustrated in FIGS. 1-4. 
It includes a rigid face member 12 and a rigid back member 14 with an 
elastomeric member 16 positioned between. Face member 12 has plunger 
opening 18 with elastomeric member 16 extending across the opening. Behind 
plunger opening 18 in back member 14 is an enlarged recess 20, which forms 
a pumping chamber 22. To pump fluid from chamber 22, a plunger 24 (FIG. 1) 
reciprocates into and out of opening 18 urging the diaphragm across 
opening 18 into and out of chamber 22. As plunger 24 is urged against the 
diaphragm, a pumping chamber outlet valve actuator 26 is opened while the 
pumping chamber inlet valve actuator 28 is closed so that fluid is forced 
from chamber 22 out of the cassette outlet 30. After the plunger has 
expelled a measured amount of fluid from pumping chamber 22, valve 
actuator 26 closes, and valve actuator 28 opens. Plunger 24 is withdrawn 
from chamber 22, whereupon liquid is drawn into pumping chamber 22 from 
primary cassette inlets 64 (FIG. 3). As will be explained in greater 
detail below, cassette 10 further includes air-in-line detection means 34 
in the fluid path between primary cassette inlet 64 and pumping chamber 
22, and air-in-line detection means 36 the fluid path between pumping 
chamber 22 and cassette outlet 30. Detection means 34 and 36 can be used 
to detect whether air is being drawn into the system and whether the 
valves in the cassette are working properly to prevent fluid from flowing 
at an uncontrolled rate through the cassette. 
Face member 12 is preferably molded from rigid plastic such as 
polycarbonate. Face member 12 has a generally flat exterior face 38 flat 
with the exception of a semi-circular guard member 40 for air-in-line 
detection means 34, a semi circular guard member 42 for air-in-line 
detection means 36, and a cylindrical housing 44 for a flow control 
regulator 46. The interior face 46 of face member 12 is flanged, having a 
peripheral pair of flanges 48 and 50, which extend completely around the 
peripheral face member 12 toward back member 14. Flanges 48 and 50 are 
spaced from each other and receive between them a peripheral flange 52 of 
the elastomeric member 16. 
Interior face 46 of face member 12 also includes flanges 56 on either side 
of the fluid path through cassette 12 in the outline of the fluid path 
(see FIG. 2) which pinch or retain elastomeric member 16 against the 
interior face 54 of back member 14 to prevent fluid from leaking out of 
the fluid path into other areas within cassette, not part of the fluid 
path. The details of the fluid path are described below. 
Face member 2 also includes valve actuator openings. A primary cassette 
inlet valve actuator opening 62 is located adjacent primary cassette inlet 
64 to allow a finger like primary inlet actuator 66 to regulate the flow 
of fluid into the cassette. Inlet actuator 66 extends through opening 62 
and is selectively moved inwardly of opening 62 to urge a portion of the 
elastomeric member 16 across the fluid path and against the inside surface 
of back member 14 to block the flow of fluid into cassette 10 from inlet 
64. The inlet actuator opening 62 and the portion of elastomeric member 16 
adjacent opening 62 form a primary cassette inlet valve. 
A secondary cassette inlet actuator opening 58 is located adjacent a 
secondary cassette inlet 32. Opening 58 permits a secondary inlet actuator 
60 to urge a portion of elastomeric member 16 across the fluid path and 
against the inside surface of back member 14 so as to block the flow of 
fluid from secondary inlet opening 32 into the cassette. Inlet actuator 
opening 58 and the portion of elastomeric member 16 adjacent opening 58 
form a secondary cassette inlet valve. Primary inlet 64 and secondary 
inlet 32 can be connected to primary and secondary sources of fluid. 
Actuators 66 and 60 are used to select which fluid is pumped by cassette 
10 at any given moment, if two liquids are being pumped to the patient at 
a given time. Alternatively, if one liquid is being administered, the 
liquid container is connected to primarily inlet 64, and the primary 
cassette inlet valve is opened while the secondary cassette inlet valve is 
closed during fluid administration. The mechanism used to drive inlet 
actuators 66 and 60 is described below. 
A pump chamber inlet actuator opening 68 (FIGS. 1 and 3) is located 
upstream of the fluid path leading to pump chamber inlet 70 (FIG. 2) which 
is positioned at the bottom of pump chamber 22. Actuator opening 68 allows 
actuator 28 to urge a portion of elastomeric member 16 adjacent opening 68 
across the fluid path leading into pump chamber 22 to block the flow of 
fluid into pump chamber 22 from cassette inlets 32 and 62 and to block the 
flow of fluid from pump chamber 22 back through cassette inlets 32 or 62. 
Pump chamber inlet actuator opening 68 and the portion of elastomeric 
member 16 adjacent opening 68 form a pump chamber inlet valve. 
A pump chamber outlet actuator opening 72 (FIGS. 1 and 4) is provided 
through face member 12 to allow a pump chamber outlet actuator 26 to urge 
a portion of elastomeric member 16 across the fluid path leading from pump 
chamber outlet 74 (FIGS. 2 and 4) to selectively block the flow of fluid 
from chamber 22 out of outlet 74. Opening 72 and the portion of 
elastomeric member 16 adjacent opening 72 form a pump chamber outlet 
valve. 
As shown in connection with inlet actuator 28 in FIG. 3, back member 14 has 
a concave, circular valve seat 75 opposite each actuator opening 58, 62, 
68, and 72. Each valve actuator 26, 28, 60, and 66 has a rounded end so 
that when a valve actuator is urged inwardly through an actuator opening, 
a portion of the elastomeric member 16 will be urged into a valve seat 75, 
insuring that flow is blocked when an actuator is actuated. 
Face member 12 further includes a pressure sensor opening 76 which allows a 
rod-like extension 78 of a pressure sensor 77 (FIG. 14) associated with 
the pump cassette driver (not shown) to contact a pressure detection 
section 80 (FIG. 4) of elastomeric member 16 positioned over a pressure 
chamber 82 in back member 14. Thus, the pressure of fluid being pumped 
from pumping chamber 22 can be monitored. If the pressure is excessive, it 
may be a sign that the needle in the patient's arm attached to the end of 
a tube 84 connected to outlet 30 has been blocked. This pressure detection 
system can also be employed to check the integrity of the valving of the 
pump chamber 22 at its inlet and outlet as will be described below. 
Finally, this pressure detection system can be used to monitor the 
patient's blood pressure, as will be discussed below. 
Back member 14 is also made of a rigid, polymeric material preferably 
polycarbonate. Back member 14 includes a peripheral flange 86 (FIGS. 3 and 
4) in which peripheral flange 48 of face member 12 nests. Flanges 48 and 
86 are secured together in a sealed fashion by welding, gluing and the 
like. 
As indicated previously, back member 14 includes cassette inlets 64 and 32. 
Secondary inlet 32 is provided with a luer taper 33 and thread like 
flanges 35 to accept a luer cap for capping inlet 32 when only one liquid 
is to be pumped, or connecting to a luer lock tubing connector when two 
liquids are to be pumped. Back member 14 also includes a recess 20 which 
forms pumping chamber 22 and a recess 82 which forms a pressure detection 
chamber. A reservoir recess 88 is also provided in back member 14 to form 
a reservoir 90 (FIGS. 2 and 3) when the unit is assembled. 
Reservoir 90 has an inlet 92 at the top of reservoir 90, and an outlet 94 
above the bottom 96 of reservoir 93. When the cassette is initially primed 
with liquid prior to pumping, the cassette is inverted from the position 
shown in FIG. 2 so that the air in the fluid path between cassette inlets 
32 and 62 and pumping chamber inlet 70 is displaced with liquid with the 
exception of the air trapped between the bottom 96 and outlet 94 of drip 
chamber 90. This trapped volume of air 93 rises to the top of drip chamber 
90 when the cassette is returned to its upright pumping position shown in 
FIGS. 2 through 4. The function of trapped air 93 will be explained below. 
Reservoir 90, pressure detection chamber 82, and pumping chamber 22 form 
portions of the fluid path between cassette inlets 32 and 62 and cassette 
outlet 30. The remaining portions of the fluid path are also formed on the 
inside surface 54 of back member 14. An inlet passage 104 (FIGS. 3 and 17) 
connects primary inlet 64 to an opening 105 (FIG. 3) inside of the 
cassette. Secondary inlet 32 is connected with an opening 103 in cassette 
10 by an inlet passage 102 (FIGS. 2 and 10). Fluid from openings 103 and 
105 combine in a channel 106 (FIGS. 2 and 3), formed between membrane 16 
and back member 14 and flows into air in line detection means 34, which 
will be described in detail below. From air in line detection means 34, 
the fluid flows through reservoir inlet 92 into reservoir 90. From 
reservoir 90, the fluid enters a passage 108, valved at its lower end by 
pump chamber inlet valve actuator 28, into pumping chamber 22 through 
pumping chamber inlet 70. A short channel 110 valved by pump chamber 
outlet valve actuator 28 connects pump chamber outlet 74 to pressure 
detection chamber 82. The fluid flows through pressure detection chamber 
82 into air in line detection means 36. From air-in line detection means 
36, fluid flows through a channel 112 which leads to flow control 
regulator 45. 
Before flowing out of cassette outlet 30, the fluid flows through flow 
control regulator 45, disclosed in copending U.S. application Ser. No. 
856,723 filed Apr. 25, 1986 entitled Liquid Flow Regulator by Giovanni 
Pastrone, which is a continuation in part of application Ser. No. 776,399 
filed Sept. 16, 1985, which is a continuation in part of application Ser. 
No. 811,262, now a U.S. Pat. No. 4,552,336, entitled "Liquid Flow 
Regulator". The disclosures of these applications and patent are hereby 
incorporated herein by reference. 
As disclosed in U.S. patent application Ser. No. 856,723, flow regulator 45 
includes a plunger 47 and a cylindrical housing 44. Plunger 47 and housing 
44 are configured to allow plunger 47 to be threaded inwardly of housing 
44 to reduce or prevent the flow of fluid through regulator 45, or to be 
threaded outwardly of cylindrical housing 44 to increase or allow fluid to 
flow through regulator 45. With this controlled inward and outward 
threading of plunger 47 in housing 44, plunger 47 ca be used to regulate 
manually the flow of fluid through the cassette when the cassette is not 
mounted in a driver, permitting regulated gravity flow of fluid from the 
I.V. solution container to the patient. Thus, when the patient is being 
transported, say in an ambulance, an I.V. set with the cassette of the 
present invention can be employed without the cassette driver to regulate 
flow of I.V. solution to the patient. But, when the patient arrives at the 
hospital, the cassette can be mounted on a cassette driver described in 
more detail below to regulate the flow of fluid more precisely than with 
the manual gravity method described above. 
Also as described in more detail in the aforesaid U.S. patent application 
Ser. No. 856,723, flow regulator plunger 47 is adapted to be pushed 
inwardly into or pulled outwardly of cylindrical housing 44 to allow rapid 
movement between on and off positions. 
II. Flow Regulator Shutoff Assembly 
The cassette driver mechanism includes a flow regulator shutoff assembly 
114 (FIGS. 5-9) to pull plunger 47 rapidly outward into the open position 
when the cassette is mounted in the driver, and to push plunger 47 inward 
into the "off" position when the cassette is removed from the driver. Flow 
regulator shutoff assembly 114 includes a gripper bracket 116 having two 
downwardly depending arms 118, 118' joined a bight portion 120 at their 
upper ends. Pivotally mounted between arms 118, 118' is a chevron-shaped 
depressor member 122. Depressor member 122 is pivotally mounted to and 
between arms 122 by a pin 124. Depressor member 122 is also pivotally 
mounted about a pin 126 which is fixedly mounted on the chassis 128 of the 
cassette driver assembly. 
Also mounted between arms 118 and 118' is a cam 130 which is fixedly 
mounted on a rotatable shaft 132. 
Cam 130 has cam surfaces 134 and 134' which engage corresponding cam 
surfaces 136 and 136' on the inside of depressor member 122. Cam 130 
further includes a driving pin 138 which extends through 130 to engage the 
lower ends of arms 118 and 118' in a manner to be described below. 
Flow regulator shutoff assembly 114 further includes a slotted pivot arm 
140 which is fixedly secure to rotatable shaft 132 which in turn is 
mounted on chassis 128 so as to allow shaft 132 to rotate freely about its 
longitudinal axis but to restrain it from translational movement in 
horizontal or vertical directions. Pivot arm 140, therefore, will pivot in 
tandem with cam 130. 
Pivot arm 140 has a slot 142 in which a roller 144 is free to slide. Roller 
144 is mounted on the driver door 146 in which cassette 10 is mounted when 
in the driver. The driver door 146 is pivotally mounted on a pin 148 which 
is also fixedly secure to chassis 128 of the driver. 
As can be seen in FIG. 6, when driver door 146 is open, pivot arm 140 is in 
a substantially horizontal position with roller 144 at the distal end 150 
of slot 142. When door 146 is pivoted to the vertical, closed position 
shown in FIG. 5, roller 144 travels in slot 142 and forces pivot arm 140 
to rotate in a counterclockwise position from the position shown in FIG. 6 
to the position shown in FIG. 5 where roller 144 is in the proximal end 
152 of slot of 142. As pivot arm 140 pivots from the substantially 
horizontal position shown in FIG. 6 to the substantially vertical position 
shown in FIG. 5, it rotates shaft 132 since pivot arm 140 is fixedly 
attached to shaft 132. As shaft 132 rotates in a counterclockwise 
position, it forces cam 130 to do likewise. As cam 130 rotates 
counterclockwise (FIG. 7), the ends of driving pin 138 engage the lower 
ends of arms 118, forcing gripper bracket 116 to pivot about pin 124. In 
addition, the counterclockwise rotation of cam 130 forces depressor member 
122 to pivot about pin 126. The counterclockwise rotation of cam 130 
forces cam surface 134 against cam surface 136 to urge depressor member to 
rotate in a clockwise direction about pin 126 until cam surface 134' 
engages cams surface 136' as shown in FIG. 7. 
When door 146 is opened again (i.e., pivoted toward the position shown in 
FIG. 6), pivot arm 140 pivots from the substantially vertical position 
shown in FIG. 5 toward the substantially horizontal position shown in FIG. 
6, forcing cam 130 to rotate clockwise(FIG. 8). As cam 130 rotates 
clockwise, driving pin 138 releases the lower ends of arms 118, and a 
spring 150 between gripper bracket 116 and depressor member 122 urges 
gripper bracket 116 to pivot clockwise about pin 124 to return to the 
position of FIG. 6. 
As cam 130 rotates clockwise as shown in FIG. 8, cam surface 134' engages 
cam surface 136' to force depressor member 122 to pivot in a clockwise 
direction about pin 126 to return to the position of FIG. 6 from position 
of FIG. 7, the position of FIG. 8 being an intermediate position between 
the positions of FIGS. 6 and 7. 
The lower ends of arm 118 include gripper fingers 152. When cassette 10 is 
mounted in the door and the door is pivoted toward the closed position, 
the knob 49 (FIGS. 6-9) of plunger 47 passes beneath the ends of fingers 
152 to a position adjacent to the lower end of depressor member 122. As 
cam 130 drives gripper bracket 116 and depressor member 122 toward the 
"closed" position of FIG. 7, fingers 152 trap knob 49 between fingers 152 
and the lower end of depressor member 122 and pull plunger 47 outwardly of 
cylindrical housing 44 to open the flow regulator 45 completely. 
Conversely, when door 146 is pivoted from the closed position toward the 
opened, roller 144 forces pivot arm 140 to rotate cam 130 in a 
counterclockwise direction which allows fingers 152 to move away from the 
lower end of depressor member 122 to release knob 49 from flow regulator 
shutoff assembly 114. As knob 49 is being released, cam 130 pivots 
depressor member 122 such that the lower end of depressor member 122 
depresses or urges plunger 47 inwardly of housing 44 (see FIGS. 8 and 9) 
so that flow regulator 45 is closed and prevents fluid from flowing 
through the cassette. When the door is fully opened (FIG. 6), the flow 
regulator is off, and the cassette can be removed. It is important that 
the flow regulator be turned off before the cassette is removed otherwise, 
fluid would flow through the cassette in an uncontrolled fashion under the 
force of gravity. 
As can be seen, when cassette 10 is mounted in the cassette driver and 
driver door 146 is closed, flow regulator 45 is opened completely by 
shutoff assembly 114. However, when door 146 is opened to remove cassette 
10 from the driver, shutoff assembly closes flow regulator 45 to prevent 
fluid from flowing through the cassette an uncontrolled rate. After the 
cassette is removed, plunger 47 can be manually threaded outwardly of 
regulator 45 to allow fluid to be administered to the patent at a 
controlled rate, if desired. 
As indicated above, flow regulator shutoff assembly 114 opens flow 
regulator 45 completely when cassette 10 is mounted on door 146 and door 
146 is closed. To prevent fluid from flowing through the cassette at an 
uncontrolled rate before plunger 24 begins pumping fluid, pumping chamber 
inlet valve actuator 28 and/or pumping chamber outlet valve actuator 26 
are positioned before pumping begins so as to block flow of fluid through 
the cassette, as shown in FIG. 14. Accordingly, before the cassette is 
placed in the cassette driver mechanism, the flow of liquid is controlled 
manually by flow regulator 45 at a rate set by medical personnel. This 
manual rate can range from zero to the maximum gravity flow rate through 
the cassette. When the cassette is placed in the driver mechanism, 
however, flow regulator 45 is opened completely, but valve actuators 26 
and/or 28 stop fluids from flowing through the cassette until the cassette 
driver pumping sequence and rates are selected by medical personnel. 
Finally, when the cassette is removed from the cassette driver mechanism, 
flow regulator shutoff assembly 114 shuts off flow regulator 45 until flow 
regulator 45 can be reset manually by medical personnel at the desired 
rate if such reset is desired. 
III. Air-In-Line Detection System 
As previously indicated, the air-in-line detection system includes an 
air-in-line detector 34 located in the fluid path between cassette inlets 
32, 64, and drip chamber 90. The air-in-line detection system also 
includes an air-in-line detector 36 positioned in the fluid path between 
pressure detection chamber 82 and flow regulator 45. Air in line detectors 
34 and 36 are substantially identical to each other. 
The air-in-line detection system also includes a pair of ultrasonic 
detectors mounted on the cassette driver an ultrasonic detector 154 (FIG. 
1) for air-in-line detector 34, and an ultrasonic detector 156 for 
air-in-line detector 36. Ultrasonic detector 154 is identical to 
ultrasonic detector 156. Therefore, only air-in-line detector 34 and 
ultrasonic detector 154 will be described in any detail. Furthermore, they 
are described in U.S. patent application Ser. No. 45,951, 5/1/87 on an 
even date herewith entitled Ultrasonic Detector, the disclosure of which 
is incorporated herein by reference. 
Air-in-line detector means 34 includes a pocket 158 formed integrally as 
part of elastomeric member 16 (see FIGS. 3, 10 and 11). Pocket 158 extends 
through an opening 160 (FIG. 11) in face member 12 and projects outwardly 
beyond the surface of face member 12. Pocket 158 has a hollow recess 162 
in it which is formed between two sidewalls 164 and 164' and an arcuate 
endwall 166. A finger 168 projects from the inner surface of back member 
14 into recess 162 and fits interferingly between sidewalls 164 and 164', 
but does not contact endwall 166. Thus, an arcuate fluid passage 170 (see 
FIGS. 3 and 11) is formed between the inside surfaces of endwall 166 and 
the perimeter of finger 168 which forms part of the fluid path through the 
cassette. Fluid passage 170 allows the fluid flowing through the cassette 
fluid path in the cassette to loop outwardly from the surface of face 
member 12 so that any air in the fluid path can be detected by ultrasonic 
detector 154 (or 156) outside of the cassette. Guard member 40 (FIGS. 3 
and 11) covers and protects the outside of endwall 166 to prevent endwall 
166 from being crushed or damaged. Ultrasonic detectors 154 and 156 are 
mounted on a cassette driver, a nondisposable item, whereas the cassette 
is inexpensive and disposable after each use. 
Ultrasonic detector 154 (see FIGS. 1, 10 and 12) includes two mirror 
housing portions 172 and 174. Housing member 172 is generally L shaped and 
is joined to the mirror imaged L-shaped housing 174 at the bottom of the 
L's so as to form a U-shaped housing assembly with a recess 176 between 
the arms of the U adapted to receive air in line detector 34. On one side 
of recess 176, housing portion 172 has an opening 178, while on the other 
side of recess 176, housing portion 174 has an opening 180. Housing 
members 172 and 174 are hollow, each containing a passage 182 for the 
necessary electrical contacts. Positioned in opening 178 is an ultrasonic 
generator 184, facing an ultrasonic receiver 186 positioned in opening 
180. Ultrasonic generator 184 is positioned directly across recess 176 
from ultrasonic receiver 186. 
Elastomeric pocket 158 has two resilient lobes 187, 187' (FIGS. 1 and 11) 
which extend outwardly from sidewalls 164, 164' in opposite directions. 
The width pocket 158 between lobes 187, 187' is somewhat less than the 
width of recess 176 between ultrasonic generator 184 and ultrasonic 
receiver 186 so that lobes 187 and 187' are compressed inwardly toward 
each other when air-in line detection means 34 is inserted into ultrasonic 
detector 154 as shown in FIG. 10. This insures that there will be good 
acoustic contact between ultrasonic generator 184 and pocket 158 and 
between ultrasonic receiver 186 and pocket 158. Thus, an ultrasonic signal 
can be transmitted across fluid passage 170 when air in line detection 
means 34 is inserted into recess 176. The transmission of ultrasonic sound 
between ultrasonic generator 184 and ultrasonic receiver 186 is greatly 
enhanced when a liquid is present in passage 170. But when air is present 
in passage 170, the transmission of ultrasonic sound through fluid passage 
170 s attenuated. This difference in ultrasonic sound transmission is 
detected by ultrasonic receiver 186. When air is present, the electrical 
signal generated by ultrasonic receiver 186 decreases. Ultrasonic detector 
154 (and 156) is coupled to a microprocessor 233 (FIG. 25) which receives 
an amplified signal generated by ultrasonic receiver 186 and subsequently 
amplified. Microprocessor 233 is preferably a 63B03R Hitachi 
microprocessor. When the signal received by processor 233 from receiver 
186 decreases, an alarm 241 (FIG. 25) is sounded by processor 233 to stop 
the pumping of fluid through the cassette if the cassette is in the fluid 
delivery cycle. Thus, when a container of medical fluid is connected 
either to cassette inlets 32 or 64 is emptied, any air drawn into the 
cassette from the empty containers will be drawn through air-in-line 
detector 34, and the presence of that air will be detected by ultrasonic 
detector 154. Alarm 241 and/or nurse call 242 is then sounded, and the 
cassette driver is stopped to prevent further pumping. If ultrasonic 
detector 154 malfunctions and does not detect the presence of air, the air 
pumped will be detected by ultrasonic detector 156. Likewise, if there is 
an air leak in the system between the fluid container and the outlet of 
the cassette before the fluid container is emptied, any air drawn into the 
system will be detected by one or the other ultrasonic detectors 154 or 
156 through air-in-line detectors 34 and 36. Other functions of the 
air-in-line detection system will be explained in the "Operation" section 
below. 
Further details of the air in line detection system of the present 
invention can be found in the aforementioned U.S. patent application Ser. 
No. 45,951, 5/1/87 filed on the same date herewith entitled Ultrasonic 
detector. 
IV. Plunger 24 
Plunger 24 and its operation is described in detail in U.S. patent 
application Ser. No. 811,262 filed Dec. 20, 1985 entitled "Fluid Infusion 
Pump Driver", the disclosure of which is incorporated herein by reference. 
V. Valve Actuator Assemblies 
As indicated previously, valve actuators 60 and 66 operate the secondary 
and primary cassette inlet valve, and valve actuators 26 and 28 operate 
the pumping chamber inlet and outlet valves. Similar mechanisms are 
employed to operate each of these pairs of valve actuators. The valve 
actuator assembly 188 drives valve actuators 60 and 66 (FIGS. 15-19). 
Valve actuator assembly 188 includes a first bracket 190 which drives 
valve actuator 66. First bracket 190 includes two arms 194 and 196 which 
are spaced from and perpendicular to each other, and joined to each other 
by a bight portion 198. First bracket 190 is pivotally mounted on the 
chassis 128 of the driver by a pivot pin 200 which is located at the 
proximal ends of arms 194 and 196 joined by portion 198 so that arms 194 
and 196 pivot about a common pivot point when operated as described below. 
Valve actuator 66 is pivotally secured to the distal, free end of arm 194. 
The distal, free end of arm 196 is driven by a cam 201 as described below. 
Valve actuator assembly 188 also includes a second bracket 192 with two 
spaced, perpendicular arms 202 and 203, which are joined to each other by 
a bight portion 204. Second bracket 192 is pivotally mounted to chassis 
128 by a pivot pin 205 which is located at the ends of arms 202 and 203 
joined by bight portion 204. The free end of arm 202 is pivotally 
connected to valve actuator 60. The free end of arm 203 engages cam 201 
described below. 
A primary spring 206 biases brackets 190 and 192 around pins 200 and 205 
such that arms 196 and 203 are urged toward cam 201. One end of spring 206 
is connected to a tab 207 which extends from bight portion 198. The other 
end of primary spring 206 is connected to a tab 208 which extends from the 
proximal end of arm 202. Tabs 207 and 208 generally extend toward cam 201 
so that spring 206 will bias arms 196 and 203 toward cam 201. 
A secondary spring 209 is attached to and between bight portions 198 and 
204 to urge arms 196 and 203 away from cam 201 in the event that primary 
spring 206 breaks. However, secondary spring 209 is weaker than primary 
spring 206 such that when the two springs are operable, arms 196 and 203 
will be urged toward cam 201. If primary spring 206 breaks, secondary 
spring 209 will urge brackets 190 and 192 to pivot around pins 200 and 205 
such that arms 196 and 2-3 pivot away from cam 201. The distal end of arm 
196 includes a flag portion 191 (FIGS. 17 and 18) which passes through an 
optical switch 193 in the event of primary spring breakage. When optical 
switch 193 is tripped, a signal is relayed to processor 233 which stops 
the driver immediately and sounds alarm 241 and/or nurse call 242. A stop 
195 is positioned adjacent cam 201, and brackets 190 and 192 have stop 
tabs 197 and 199 which project from the proximal ends of arms 196 and 203. 
If primary spring 206 breaks, brackets 190 and 192 will pivot around pins 
200 and 205 until stop tabs 197 and 199 contact stop 195 before which 
point flag portion 191 would have passed through switch 193. 
As shown in FIGS. 17-19, actuators 60 and 66 are elongated rods. As 
indicated previously, the proximal ends of actuators 60 and 66 are 
pivotally connected to arms 194 and 202 of brackets 190 and 192, 
respectively. The distal ends of actuators 60 and 66 are supported in 
openings 250 and 251 (FIGS. 13 and 17-19) in the front panel 252 of the 
driver. 
Cam 201 is circular in shape and is eccentrically mounted on a motor shaft 
210. Shaft 210 is operated by a stepper motor 211 (FIG. 16). When cassette 
10 is placed in driver door 146 and the driver door is closed to its 
vertical position, cam 201 is moved to the position where both valve 
actuators 60 and 66 are fully extended (FIG. 17) toward cassette 10 so as 
to close the primary and secondary cassette inlet valves. Specifically, 
valve actuators 60 and 66 urge elastomeric member 16 across the fluid 
passages leading from inlets 103 and 105 into the cassette. When a liquid 
is to be pumped through primary cassette inlet 64, primary inlet actuator 
66 is retracted by the clockwise rotation of cam 201 by motor 211 from the 
position shown in FIG. 17 to the position shown in FIG. 18. Cam 201 
engages arm 196 of bracket 190 and urges bracket 190 to pivot clockwise 
about pivot pin 200 against the bias of spring 206. As bracket 190 pivots 
about pivot pin 200, arm 194 retracts actuator 66, thereby allowing liquid 
to flow through primary cassette inlet 64 through opening 105. 
When cam 201 is in the position as shown in FIG. 1 with the primary 
cassette inlet valve open, the secondary inlet actuator 60 remains in the 
extended position, urging elastomeric member 16 across the fluid passage 
from inlet 103 (FIG. 18) into the cassette. Secondary inlet actuator 60 is 
held in the extended position by the bias of primary spring 206. When cam 
201 is in the position shown in FIG. 18, arm 203 does not contact it. 
Primary spring imparts a clockwise bias to second bracket 192 which urges 
actuator 60 into the closed position shown in FIG. 18. Since cassette 10 
is in a fixed position in the driver door 146 when cassette 10 is mounted 
in the driver, cassette 10 acts as a stop to prevent arm 203 from 
contacting cam 201 when primary inlet actuator 66 is retracted as shown in 
FIG. 18. 
When fluid is to be pumped through secondary cassette inlet 32, motor 211 
is reversed and turns cam 201 counterclockwise from the position shown in 
FIG. 18 to the position shown in FIG. 19 where cam 201 engages arm 203 of 
second bracket 192 and pivots bracket 192 counterclockwise about pivot pin 
205. When arm 202 of bracket 192 pivots counterclockwise, valve actuator 
60 is retracted allowing fluid to flow through opening 103 into the 
cassette. When the secondary cassette inlet is open, the primary cassette 
inlet remains closed because primary cassette inlet actuator 66 remains in 
the extended position under the bias of primary spring 206. When cam 201 
is in the position as shown in FIG. 19, arm 196 of first bracket 190 no 
longer contacts cam 201 because cassette 10 operates as a stop against 
clockwise rotation of bracket 190 under the bias of spring 206 when cam 
201 is in that position. This keeps the secondary cassette inlet closed 
while the primary inlet is open. 
It can be seen, therefore, that cassette inlet valve actuator assembly 188 
allows the following possible cassette inlet valve positions: (1) both the 
primary and secondary cassette inlet valves closed; (2) the primary inlet 
valve open and the secondary inlet valve closed; and (3) the secondary 
cassette inlet valve open and the primary cassette inlet valve closed. In 
normal operation, valve actuator assembly 188 does not permit both the 
primary and secondary cassette inlet valves to be open simultaneously. 
A second valve actuator assembly 212 is used to operate pumping chamber 
outlet and inlet valve actuators 26 and 28 (FIGS. 20-21). Pumping chamber 
outlet valve actuator 26 is operated by a first bracket 23 which is 
pivotally mounted on a pivot pin 214 on chassis 128. First bracket 213 has 
two spaced, perpendicular arms 215 and 216 fixedly secured and integrally 
formed with a bight portion 217. The proximal end of arm 215 is pivotally 
secured to pivot pin 214, and the distal end of arm 215 is pivotally 
secured to actuator 26. The proximal end of arm 216 is pivotally mounted 
to pivot pin 214, and the distal end of arm 216 is urged toward a cam 218 
described below by a spring 219. One end of spring 219 is attached to a 
tab 220 which extends from the proximal end of arm 216. The other end of 
spring 219 is attached to a tab 221 raised from chassis 128. Spring 219, 
therefore, biases first bracket 213 such that arm 216 will be urged toward 
a cam 218. 
Valve actuator assembly 212 also includes a second bracket 222 pivotally 
mounted about pivot pin 214. Second bracket 222 includes a first arm 223, 
the proximal end of which is pivotally secured to pin 214, and the distal 
end of which is pivotally secured to the proximal end of valve actuator 
28. Second bracket 222 also includes a second arm 224, the proximal end of 
which is pivotally secured about pin 214, the distal end of which is free 
to be engaged by cam 218. Arms 223 and 224 are perpendicular to each other 
and fixedly joined to each other by a bight portion 225. Second bracket 
222 further includes a tab 225 which extends from the proximal end of 
second arm 224. The free end of tab 225 is attached to one end of a spring 
226 which biases arm 224 toward cam 218. The other end of spring 226 is 
attached to a tab 227 which is raised from chassis 128. 
Cam 218 is eccentrically mounted on a motor shaft 228 operated by a stepper 
motor 229. As cam 218 is driven by motor 229 in counterclockwise from the 
position shown in FIG. 20, cam 218 engages arm 216, forces first bracket 
213 to pivot counterclockwise about pin 214, and causes valve actuator 26 
to retract against the bias of spring 219. When valve actuator 26 is 
retracted, the pumping chamber outlet valve is opened. When cam 218 is 
driven counterclockwise against arm 216, arm 224 of bracket 222 remains 
stationary, and spring 226 will force valve actuator 28 to remain extended 
against the pumping chamber inlet valve, keeping pumping chamber inlet 
valve closed. As cam 218 is driven by motor 229 in a clockwise from the 
position shown in FIG. 20, it engages arm 224, pivots bracket 222, and 
forces valve actuator 28 to retract against the bias of spring 226, 
opening the pumping chamber inlet valve. When cam 218 is driven 
counterclockwise against arm 224, arm 216 of bracket 213 remains 
stationary, and spring 219 will force valve actuator 26 to remain extended 
against the pumping chamber outlet valve, keeping the pumping chamber 
outlet valve closed. It can be seen that valve actuator assembly 212 
permits both the pumping chamber inlet and outlet valves to be closed, or 
allows only one of them to be opened at a time. More importantly, valve 
actuator assembly 212 prevents both the pumping chamber inlet and outlet 
valves from being opened simultaneously so that fluid cannot flow through 
the cassette at an uncontrolled rate under the force of gravity during the 
pumping cycle. 
The proximal ends of actuators 26 and 28 are pivotally connected to 
brackets 213 and 222, as indicated above. The distal ends of actuators 260 
and 28 are supported in openings 254 and 256 (FIGS. 14 and 15) in front 
panel 252. Since valve actuator assemblies 188 and 212 are driven by 
separate motors 211 and 229, and since plunger 24 is driven by a motor 
separate from stepper motors 211 and 229, the three motors must be 
operated in a synchronized fashion, and the positions of each during the 
operations of the cassette driver must be monitored. 
To monitor the position of cam 201 of valve actuator assembly 188 (and 
hence monitor the position of valve actuators 60 and 66), a flag 230 is 
fixedly mounted on cam 210. Flag 230 is thin, pie-shaped strip of metal 
with a small notch 231 on its radial edge. As cam 201 moves 
counterclockwise from the position shown in FIG. 18 to the position shown 
in FIG. 19, motor 211 takes a set number of steps, preferably 24 steps. 
Notch 231 is not centered on the radial edge of flag 230, but is offset to 
one side. Valve actuator assembly 188 further includes an optical switch 
232 through which the radial edge of flag 230 passes as cam 201 moves from 
position shown in FIG. 18 to the position shown in FIG. 19 and back again 
during its normal operation. Optical switch 232 passes a beam of light 
across the space through which flag 230 passes. Flag 230 breaks the beam 
of light as it is passing through, except for notch 231 which allows light 
to pass when notch 231 passes through switch 232. Optical switch 232 is 
coupled to microprocessor 233 (FIG. 25) to relay to microprocessor 233 
whether light is being transmitted or whether it is being blocked by flag 
230. Microprocessor 233 also controls stepper motor 211 such that as the 
stepper motor 211 moves stepwise clockwise or counterclockwise, the 
microprocessor can determine whether cam 201 is out of position. For 
instance, as flag 230 passes through switch 232 as it moves from the 
position shown in FIG. 18 to the position shown in FIG. 19, there will be 
a fairly large number of steps in which light is transmitted across switch 
232 before flag 230 breaks the optical beam and prevents light from being 
transmitted. As flag 230 continues its movement towards position shown in 
FIG. 19, there will be a small number of steps during which the radial 
edge portion 234 (FIG. 23A) counterclockwise of notch 231 prevents the 
passage of light. Then, notch 231 will pass through optical switch 232, 
allowing light to pass for a small number of steps, whereupon the larger 
radial edge portion 235 passes through switch 232 for a fairly large 
number of steps of motor 211. This is followed by a fairly large number of 
steps where light passes across switch 232 after portion 235 passes 
through switch 232. 
It can be seen that as cam 201 moves from position shown in FIG. 18 to the 
position shown in FIG. 19, there will be a pattern of a short number of 
steps when portion 234 passes through switch 232 followed by a short 
number of steps in which notch 231 passes through switch 232 and a longer 
period of time in which portion 235 passes through notch 232. This 
repeated dark/light/dark pattern is correlated by microprocessor 233 to 
the position where cam 201 should be during its cycle. If motor 211 is not 
"in synch" with the preprogrammed dark/light/dark values in microprocessor 
233, microprocesser 233 can advance or retard motor 211 the appropriate 
number of steps to synchronize the positions of valve actuators 60 and 66 
with the positions where they should be during driver operation. 
Similarly, in valve actuator assembly 212, cam 218 has a flag 236 attached 
to it. Flag 236 is generally pie shaped, having a radial edge with a notch 
237 in it. An optical switch is positioned so that flag 236 passes through 
it as flag 236 moves from the position shown in FIG. 22(B) where valve 
actuator 26 is retracted to the position shown in FIG. 22(C) where valve 
actuator 28 is retracted. Notch 237 is likewise offset to provide a small 
radial edge portion 239 and a large radial edge portion on either side of 
notch 237. Thus, when flag 236 moves from the position shown in FIG. 22(C) 
to the position shown in FIG. 22(C), switch 238 will detect a short period 
of darkness as radial edge portion 239 passes, a short period of light 
when notch 237 passes, and a long period of darkness as portion 240 passes 
through switch 238. Microprocessor 233 is coupled to optical switch 238 
such that the periods of light and darkness can be correlated stepwise to 
the number of steps taken by stepper motor 229 between the positions of 
FIGS. 22(C) and 22(B). Therefore, as flag 236 moves back and forth between 
these two positions opening and closing the pumping chamber inlet and 
outlet valves, microprocessor 233 can compare the actual position of cam 
218 (and hence the positions of valve actuators 26 and 28) with the 
desired, preprogrammed position to either advance or retard stepper motor 
229 appropriately. Not only are the positions of cams 201 and 218 
monitored during the pumping cycle, but the positions of the cams are 
checked before pumping begins. After the cassette is placed in door 146 
and the doors closed, motor 211, for instance, will drive cam 201 back and 
forth between the position shown in FIGS. 18 and 19 while optical switch 
232 checks the actual position of flag 230, and microprocessor 233 will 
stop stepper motor 211 once it is determined that cam 201 is in the proper 
position to begin the pumping sequence. In the case where only a single 
fluid is to be pumped, for instance, that position will be when valve 
actuator 56 is retracted and valve actuator 60 is extended (FIG. 18). 
Similarly, during this pre pumping check, motor 229 will move flag 236 and 
cam 218 back and forth between the positions of FIGS. 22(B) and (C) to 
position the pumping chamber inlet and outlet valve actuators 26 and 28 in 
their appropriate positions to begin the pumping cycle, namely, with both 
valve actuators 26 and 28 fully extended, (i.e., the positions shown in 
FIGS. 20, and 22(A). Thus, the pumping chamber inlet and outlet valves can 
be checked according to the procedure described below. Once microprocessor 
233 verifies that flag 236 is in the proper position, the valve checking 
sequences and pumping sequences described below can commence. 
Plunger 24 is also operated with a stepper motor (not shown). An optical 
flag is also attached to the plunger stepper motor shaft so that an 
optical switch (not shown) and microprocessor 233 monitor and position 
plunger 24 before and during the pumping cycle to synchronize plunger 24 
with the operation of actuators 26, 28, 60, and 66. 
VI Operation 
When pumping only one liquid at a time, the liquid container with the 
liquid to be pumped is connected to primary cassette inlet 64, and the 
secondary cassette inlet 32 is closed with a luer-type locking cap (not 
shown). The cassette is primed with fluid by opening regulator 45 and 
initially inverting the cassette from the position shown in FIG. 2 to 
purge the fluid path between the cassette inlets and the pumping chamber 
of air except, of course, for the trapped volume 100). The pumping chamber 
and the fluid path beyond it are purged of air by returning the cassette 
to the upright position of FIG. 2. Regulator 45 is then either closed or 
set manually to a desired flow rate until the cassette is mounted in the 
cassette driver. Once the cassette is mounted in the driver, the flow 
regulator shutoff assembly 114 automatically opens regulator 47 and the 
cassette valves are tested as described below. 
Once the cassette inlet valve actuators 60 and 66, pumping chamber inlet 
and outlet valve actuators 26 and 28, and plunger 24 are properly 
synchronized as described above, air in line detector 34 and pressure 
detection chamber 82 are used to test whether valve actuators 26, 28, 60, 
and 66 are cooperating with the disposable cassette 10 to provide adequate 
valving of fluid in the cassette. The sequence for such testing is 
illustrated in FIG. 24. To test the inlet and outlet valves of pumping 
chamber 22, inlet valve actuator 28 and outlet valve actuator 26 are 
extended into openings 68 and 72, respectively to block flow of fluid into 
and out of pumping chamber 22 (Step A FIG. 24). With valve actuators 26 
and 28 in the extended positions, plunger 24 is urged against elastomeric 
member 16 across plunger opening 18 to pressurize pumping chamber 22 (Step 
B). Plunger 24 is held in this position for the "WAIT" period (Step C), 
pressurizing chamber 22 for a short period of time, whereupon outlet valve 
actuator 26 is retracted to allow pressurized liquid to escape pumping 
chamber 22, while inlet valve actuator 28 is held in its "extended" 
position (Step D). When outlet valve actuator 26 is released (Step D), the 
pressurized liquid within chamber 22 surges into pressure detection 
chamber 82, producing a pressure pulse or spike in chamber 82. When the 
pumping chamber inlet and outlet valves are functioning properly, the 
magnitude of this pulse will be constant from cassette to-cassette. 
However, when a cassette with poorly functioning pumping chamber inlet 
and/or outlet valves is encountered, the pressure pulse produced within 
chamber 82 during this valve test procedure will be noticeably lower 
because a certain amount of pressurized liquid from chamber 22 will have 
leaked past either the pumping chamber inlet or outlet valves during the 
"WAIT" period. If the pressure pulse produced by this test procedure in 
pressure detection chamber 82 is lower than expected, it is assumed that 
the pumping chamber inlet and/or outlet valves are functioning improperly 
so that the cassette is rejected. 
The magnitude of the spike is detected by pressure sensor 77 which is 
coupled to microprocessor 233. The details of the operation of pressure 
sensor 77 are described in U.S. patent application Ser. No. 45,949 filed 
(5/1/87) entitled PRESSURE SENSOR ASSEMBLY FOR DISPOSABLE PUMP CASSETTE 
filed on an even date herewith by Fellingham et al, which is incorporated 
herein by reference. Microprocessor 233 compares the value of the signal 
generated by sensor 77 to a stored value. If the stored value is 
significantly greater, microprocessor 233 will sound an alarm 241 and a 
nurse call 242 and the pump driver will not function unless a new cassette 
is used. 
The pump chamber inlet and outlet valve test procedure described above is 
first done automatically by the cassette driver immediately after the 
cassette is installed. Thereafter, the same test procedure can be done 
periodically during fluid delivery to insure the continuing integrity of 
the pumping chamber inlet and outlet valves during fluid delivery. 
The test procedure is performed periodically in the fashion illustrated in 
FIG. 24, steps A-E. The pumping chamber inlet valve is closed (step A) 
while the pumping chamber outlet valve is closed. Chamber 22 is 
pressurized by extending plunger 24 a short distance into chamber 22 (step 
B). The plunger is held for the "WAIT" period (step C). The pumping 
chamber outlet valve is opened and the pressure spike detected in chamber 
22 (step D). If the pressure spike is of sufficient magnitude, plunger 24 
extends further into chamber 22, (step E) to displace the rest of the 
fluid in chamber 22 and pump it into the patient. The pumping chamber 
outlet valve is closed (last part of step E), and the inlet valve is 
opened (step F) while the plunger is retracted to fill the pumping chamber 
with liquid. 
Once it is initially established that the pumping chamber inlet and outlet 
valves are working properly, air-in-line detector 34 can be used to 
establish whether the cassette inlet valves associated with primary 
cassette inlet 64 and secondary cassette inlet 32 are working properly. To 
test the cassette inlet valves, the pumping chamber outlet valve is closed 
and the pumping chamber inlet valve is open (end of step E). At the same 
time, the two inlet valves are closed (step G), and plunger 24 pressurizes 
pump chamber 22 (step H). The system is then held pressurized for a short 
period of time (step I). If either of the two cassette inlet valves leak, 
liquid will flow out of the primary cassette inlet 64 or secondary 
cassette inlet 32. This reverse displacement of fluid will be accompanied 
by the movement of trapped air 100 in drip chamber 90 upwardly into air in 
line detector 34 as shown in FIG. 3. Ultrasonic detector 154 will detect 
this presence of air, and relay this to microprocessor 233 which sounds 
alarm 241 and nurse call 242. Thus, the cassette will be rejected. If the 
primary and secondary cassette inlet valve are good, plunger 24 is 
retracted (step J) for the "normal cycle" (step K) of fluid delivery 
described below. 
In the "normal cycle" pumping sequence with only one liquid being 
administered. The pumping chamber inlet valve is closed and the pumping 
chamber outlet is opened whereupon plunger 24 is urged through opening 18 
against elastomeric member 16 to displace the fluid from pumping chamber 
22 out cassette outlet 30 to the patient. The amount of fluid during the 
fluid delivery stroke is controlled precisely by operating plunger 24 with 
a conventional stepping motor. By operating plunger 24 with a stepper 
motor, the displacement of plunger 24 against elastomeric member 16 can be 
controlled precisely for each delivery stroke by advancing the stepper 
motor the same number of steps for each delivery stroke such that a 
constant volume of fluid is displaced from pumping chamber 22 for each 
stroke. 
To refill pumping chamber 22 for the next delivery stroke, the pumping 
chamber outlet valve is closed, the pumping chamber inlet and the primary 
cassette inlet valves are opened, and then plunger 24 is retracted the 
same number of steps it was advanced during the previous fluid delivery 
stroke. Since both the pumping chamber inlet valve and the primary 
cassette inlet valve are opened, fluid will be drawn from the fluid 
container connected to the primary cassette inlet as plunger 24 is 
retracted stepwise. Once plunger 24 is retracted to its starting or "home" 
position, the pumping chamber inlet and the primary cassette inlet valves 
are closed and the pumping chamber outlet valve is opened for the next 
stepwise fluid delivery stroke of plunger 24. The fluid delivery stroke is 
then repeated followed by the pumping chamber refill retraction stroke by 
plunger 24 with the pumping chamber inlet and outlet valves appropriately 
valving the flow of fluid on delivery and refill. As can be seen, the 
pumping of fluid when a single fluid is being pumped is fairly simple and 
straightforward. 
However, multiple fluid delivery is also possible. When two liquids are to 
be pumped, the container containing the primary liquid is connected to the 
primary cassette inlet 64. The secondary liquid container is connected to 
the secondary cassette inlet 32 by removing the luer lock cap on inlet 32 
and connecting the secondary fluid container to inlet 32 with a luer 
connector. The valving of the pumping chamber inlet and outlet valves 
during fluid delivery and pumping chamber refill strokes are the same 
during a two fluid delivery as with the single fluid delivery procedure 
described above. However, the cassette inlet valving is different. During 
single fluid delivery, of course, the secondary cassette inlet valve is 
always closed and only the primary inlet valve is open during the refill 
of the pumping chamber. However, when pumping two fluids, the primary and 
secondary cassette inlet valves are each opened and closed for selected 
periods of time during the pumping chamber refill stroke. For instance, if 
the two fluids are to be mixed in a fifty-fifty proportion, the primary 
cassette inlet valve is opened during the first half of the total number 
of strokes comprising the pumping chamber refill stroke of plunger 24. 
During the first half of the retraction stroke of plunger 24, the 
secondary cassette inlet valve is closed. However, during the second half 
of the retraction/refill stroke of plunger 24, the secondary cassette 
inlet valve is opened while the primary cassette inlet valve is closed. 
Since plunger 24 is controlled stepwise, it is possible to ascertain 
exactly when to switch the two cassette inlet valves from open to closed 
and vice versa to achieve the desired proportioning of the two fluids. 
Often, however, the primary fluid is a diluent such as saline solution 
whereas the secondary fluid is a concentrated drug. In such situations, a 
fifty-fifty mixture may be undesirable, so the secondary cassette inlet 
valve may be opened only 10 to 20 percent of the steps during the pumping 
chamber refill stroke of plunger 25 while the primary cassette inlet valve 
is opened 80 to 90 percent of the steps comprising the refill stroke of 
plunger 24. 
It can be seen, therefore, that virtually any desired concentration of 
secondary fluid in primary fluid can be delivered to the patient using the 
cassette and driver of the present invention simply by operating inlet 
actuator 60 and 66 in sequence and in tandem with plunger 24 during the 
pumping chamber refill stroke as described above. Because cassette inlet 
actuators 60 and 66 cannot be simultaneously retracted as described above 
(i.e., one is always extended closing its cassette inlet valve), one 
cannot get gravity flow between the primary and secondary fluid containers 
through the cassette. 
As indicated previously, pressure sensor 77 and pressure detection chamber 
82 are employed to detect whether the pumping chamber inlet and outlet 
valves are functioning properly. However, once the pumping chamber inlet 
and outlet valves are checked for proper functioning, pressure sensor 77 
and pressure detection chamber 82 can also be used to monitor the 
patient's blood pressure. During a pumping chamber filling stroke of 
plunger 24 (e.g. step F in FIG. 24), the pumping chamber outlet valve is 
closed such that the pressure of the fluid in the fluid path from the 
pumping chamber outlet valve to the patient is at the patient's blood 
pressure. Thus, real time measurements of the patient's blood pressure can 
be taken through the cassette. The patient's blood pressure is stored in 
memory 243. During the operation of cassette 10, microprocessor will 
compare the patient's blood pressure to previously recorded values of the 
same patient's pressure. If the patient's blood pressure drops or 
increases dramatically over time, microprocessor 243 will sound alarm 241 
and/or nurse call 242 to alert medical personnel. 
Pressure sensor 77 is also used to detect occlusions in the line leading 
from the cassette outlet to the patient. When plunger 24 is extended 
during the fluid delivery stroke, the pressure in pressure chamber 82 is 
monitored by sensor 77 and microprocessor 233. If the pressure is 
excessive, it indicates the patient line has been wholly or partially 
occluded. Microprocessor sounds alarm 241 and nurse call 242. 
Air-in-line detector 154 and 156 are also interfaced with microprocessor 
233 (FIG. 25) so that microprocessor 233 will stop the driver and sound 
alarm 241 and nurse call 242 if air is detected in the cassette or if 
detector 154 detects a bad inlet valve. 
A LDC/LED display 244 (FIG. 25) is also interfaced with microprocessor 244 
so that input or output values of delivery rates, delivery volumes, 
patient blood pressure and the like can be displayed to an operator. 
Likewise, message codes can be displayed to tell the operator why an alarm 
has been sounded. 
A keyboard 245 is provided to input values of delivery rates, delivery 
volumes, patient blood pressure, concentration and the like. 
Microprocessor 233 can be programmed to deliver a given volume of primary 
or secondary fluid over a desired period of time, for instance. It is also 
programmed to set the concentration of secondary liquid in primary 
solution when two liquids are simultaneously delivered. 
An AC/DC power supply 246 is provided and includes a battery charger to 
continuously monitor and charge batteries provided in the driver for 
operation without AC current. In the event of battery failure, alarm 241 
is sounded. 
Finally, a dataway 247 is provided to allow a printer or other display to 
be connected to the driver to get data printouts of patient blood pressure 
over time, and fluid delivery times, volumes and rates. 
While one embodiment has been disclosed and described, other embodiments 
will become apparent to those of ordinary skill in the art. Such 
embodiments are to be construed within the ambit of the claims which 
follow, unless by their terms, the claims expressly state otherwise.