Antibacterial Drugs

**ORBACTIV** **** **(oritavancin)**

  
Orbactiv (oritavancin) is a semisynthetic lipoglycopeptide antibacterial
drug. It exerts concentration-dependent bactericidal activity in vitro against
_S. aureus, S. pyogenes, and E. faecalis_.  
Orbactiv is specifically indicated for the treatment of adult patients with
acute bacterial skin and skin structure infections (ABSSSI) caused by
susceptible isolates of the following Gram-positive microorganisms:  
 _Staphylococcus aureus (including methicillin-susceptible and methicillin
-resistant isolates)  
 Streptococcus pyogenes  
 Streptococcus agalactiae  
 Streptococcus dysgalactiae  
 Streptococcus anginosus group (includes S. anginosus, S. intermedius, and S.
constellatus)  
 Enterococcus faecalis (vancomycin-susceptible isolates only)_  
Orbactiv is supplied as a solution for intravenous infusion. The recommended
dose is a single 1200 mg dose administered by intravenous infusion over three
hours in patients 18 years and older.  
  
**DALVANCE** **** **(dalbavancin)**

  
Dalvance (dalbavancin) is a lipoglycopeptide antibacterial drug proposed for
the treatment of adult patients with acute bacterial skin and skin structure
infections (ABSSSI) caused by susceptible isolates of the following Gram-
positive microorganisms:  
 _Staphylococcus aureus (including methicillin-resistant [MRSA] isolates)  
 Streptococcus pyogenes  
 Streptococcus agalactiae  
 Streptococcus anginosus group (including S. anginosus, S. intermedius, S.
constellatus) _

_ Enterococcus faecalis (vancomycin-susceptible isolates only)_

______________Because of its long elimination half-life, the dosing regimen is
1000 mg on Day 1 and 500 mg on Day 8, administered intravenously (IV) over 30
minutes.______________

**VIBATIV** **** **(telavancin)**

  
Vibativ (telavancin) is a bactericidal, once-daily, injectable
lipoglycopeptide antibiotic with a dual mechanism of action whereby Vibativ
both inhibits bacterial cell wall synthesis and disrupts bacterial cell
membrane function. Vibativ is specifically indicated for the treatment of
adult patients with complicated skin and skin structure infections (cSSSI)
caused by susceptible isolates of the following Gram-positive microorganisms:  
 _Staphylococcus aureus (including methicillin-susceptible and -resistant
isolates)  
 Streptococcus pyogenes  
 Streptococcus agalactiae  
 Streptococcus anginosus group (includes S. anginosus, S. intermedius, and S.
constellatus)  
 Enterococcus faecalis_ (vancomycin-susceptible isolates only)  
 Hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP)
caused by susceptible isolates of _Staphylococcus aureus_.  
Vibativ is supplied as a powder for reconstitution onto a solution designed
for intravenous administration. The recommended initial dose is 10 mg/kg
administered over a 60-minute period in patients >18 years of age by
intravenous infusion once every 24 hours for 7 to 14 days.  
  
 **SIVEXTRO  (tedizolid) **

Sivextro (tedizolid) is an oxazolidinone-class antibacterial drug indicated
for the treatment of adult patients with acute bacterial skin and skin
structure infections (ABSSSI) caused by susceptible isolates of the following
Gram-positive microorganisms:  
 _Staphylococcus aureus (including methicillin-susceptible and methicillin
-resistant isolates)  
 Streptococcus pyogenes  
 Streptococcus agalactiae  
 Streptococcus anginosus group (includes S. anginosus, S. intermedius, and S.
constellatus)  
 Enterococcus faecalis_ (vancomycin-susceptible isolates only).  
The recommended dosage is 200 mg administered once daily for 6 days. Sivextro
can be given orally (with or without food) or as an intravenous (IV) infusion
over 1 hour for patients 18 years of age or older. ********************  
  
**_To reduce the development of drug-resistant bacteria and maintain the
effectiveness of these drugs-oritavancin, dalbavancin, telavancin and
tedizolid should be used only to treat infections that are proven or strongly
suspected to be caused by susceptible bacteria._**  
********************