Pyrantel pamoate

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NOTE: Most over the counter (OTC) are not reviewed and approved by the FDA. However, they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies.

# Overview
Pyrantel pamoate is an anthelmintic that is FDA approved for the treatment of pinworms.   Common adverse reactions include diarrhea, nausea, vomiting, dizziness, headache and somnolence.

# Adult Indications and Dosage

## FDA-Labeled Indications and Dosage (Adult)
- Pyrantel Pamoate Suspension is used for the treatment of pinworms.
- Dosage:
- 63-87 lbs. (29-39 kg): 1 1/2 teaspoonful (7.5 mL)
- 88-112 lbs. (40-50 kg): 2 teaspoonful (10.0 mL)
- 113-137 lbs. (51-62 kg): 2 1/2 teaspoonful (12.5 mL)
- 138-162 lbs. (63-73 kg): 3 teaspoonful (15.0 mL)
- 163-187 lbs. (74-84 kg): 3 1/2 teaspoonful (17.5 mL)
- 188 lbs. (85 kg and over): 4 teaspoonful (20.0 mL)

## Off-Label Use and Dosage (Adult)

### Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Pyrantel pamoate in adult patients.

### NonGuideline-Supported Use
- Ascariasis
- Dosage: A single dose of 11 milligrams/kilogram 
- Infection by Moniliformis
- Dosage: 11 milligrams/kilogram in a single dose, repeated twice, 2 weeks apart 
- Infection by Uncinaria
- 11 milligrams/kilogram/day for 3 days 
- Trichostrongyliasis
- Dosage: 11 milligrams/kilogram (maximum 1 gram) 

# Pediatric Indications and Dosage

## FDA-Labeled Indications and Dosage (Pediatric)
- Pyrantel Pamoate Suspension is used for the treatment of pinworms in children 2 years to 12 years of age.
- Dosage:
- Less than 25 lbs. (11 kg) or under 2 years old: Do not use unless directed by a physician
- 25-37 lbs. (11-16 kg): 1/2 teaspoonful (2.5 mL)
- 38-62 lbs. (17-28 kg): 1 teaspoonful (5.0 mL)
- 63-87 lbs. (29-39 kg): 1 1/2 teaspoonful (7.5 mL)
- 88-112 lbs. (40-50 kg): 2 teaspoonful (10.0 mL)
- 113-137 lbs. (51-62 kg): 2 1/2 teaspoonful (12.5 mL)
- 138-162 lbs. (63-73 kg): 3 teaspoonful (15.0 mL)
- 163-187 lbs. (74-84 kg): 3 1/2 teaspoonful (17.5 mL)
- 188 lbs. (85 kg and over): 4 teaspoonful (20.0 mL)

## Off-Label Use and Dosage (Pediatric)

### Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Pyrantel pamoate in pediatric patients.

### NonGuideline-Supported Use
- Ascariasis
- Dosage: A single dose of 11 milligrams/kilogram 
- Infection by Moniliformis
- Dosage: 11 milligrams/kilogram in a single dose, repeated twice, 2 weeks apart 
- Infection by Uncinaria
- 11 milligrams/kilogram/day for 3 days 
- Trichostrongyliasis
- Dosage: 11 milligrams/kilogram (maximum 1 gram) 

# Contraindications
- Pregnant
- Liver disease

# Warnings
- Keep this and all mediactions out of reach of children.
- In case of accidental overdose, seek professional assistance or contact a Poison Control Center immediately.

# Adverse Reactions

## Clinical Trials Experience
- Abdominal cramps, nausea, vomiting, diarhea, headache or dizziness sometimes occur after taking this drug.

## Postmarketing Experience
There is limited information regarding Pyrantel pamoate Postmarketing Experience in the drug label.

# Drug Interactions
There is limited information regarding Pyrantel pamoate Drug Interactions in the drug label.

# Use in Specific Populations

### Pregnancy
Pregnancy Category (FDA): C
There is no FDA guidance on usage of Pyrantel pamoate in women who are pregnant.
Pregnancy Category (AUS): B2
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Pyrantel pamoate in women who are pregnant.

### Labor and Delivery
There is no FDA guidance on use of Pyrantel pamoate during labor and delivery.

### Nursing Mothers
There is no FDA guidance on the use of Pyrantel pamoate in women who are nursing.

### Pediatric Use
There is no FDA guidance on the use of Pyrantel pamoate in pediatric settings.

### Geriatic Use
There is no FDA guidance on the use of Pyrantel pamoate in geriatric settings.

### Gender
There is no FDA guidance on the use of Pyrantel pamoate with respect to specific gender populations.

### Race
There is no FDA guidance on the use of Pyrantel pamoate with respect to specific racial populations.

### Renal Impairment
There is no FDA guidance on the use of Pyrantel pamoate in patients with renal impairment.

### Hepatic Impairment
There is no FDA guidance on the use of Pyrantel pamoate in patients with hepatic impairment.

### Females of Reproductive Potential and Males
There is no FDA guidance on the use of Pyrantel pamoate in women of reproductive potentials and males.

### Immunocompromised Patients
There is no FDA guidance one the use of Pyrantel pamoate in patients who are immunocompromised.

# Administration and Monitoring

### Administration
Oral

### Monitoring
There is limited information regarding Pyrantel pamoate Monitoring in the drug label.

# IV Compatibility
There is limited information regarding the compatibility of Pyrantel pamoate and IV administrations.

# Overdosage
There is limited information regarding Pyrantel pamoate overdosage.  If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

# Pharmacology

## Mechanism of Action
There is limited information regarding Pyrantel pamoate Mechanism of Action in the drug label.

## Structure
There is limited information regarding Pyrantel pamoate Structure in the drug label.

## Pharmacodynamics
There is limited information regarding Pyrantel pamoate Pharmacodynamics in the drug label.

## Pharmacokinetics
There is limited information regarding Pyrantel pamoate Pharmacokinetics in the drug label.

## Nonclinical Toxicology
There is limited information regarding Pyrantel pamoate Nonclinical Toxicology in the drug label.

# Clinical Studies
There is limited information regarding Pyrantel pamoate Clinical Studies in the drug label.

# How Supplied
Pyrantel pamoate suspension 32 fl. oz. (946 mL)

## Storage
Store at 2025 C (6877 F)

# Images

## Drug Images

## Package and Label Display Panel

# Patient Counseling Information
There is limited information regarding Pyrantel pamoate Patient Counseling Information in the drug label.

# Precautions with Alcohol
Alcohol-Pyrantel pamoate interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

# Brand Names
- Ascarel 
- Pamix
- Pin-X

# Look-Alike Drug Names
There is limited information regarding Pyrantel pamoate Look-Alike Drug Names in the drug label.

# Drug Shortage Status

# Price