Ergot

# Overview
Ergot is the common name of a fungus in the genus Claviceps that is parasitic on certain grains and grasses. The form the fungus takes to winter-over is called a sclerotium, and this small structure is what is usually referred to as 'ergot', although referring to the members of the Claviceps genus as 'ergot' is also correct.  There are about 50 known species of Claviceps, most of them in the tropical regions. Economically important species are Claviceps purpurea (parasitic on grass and cereals), C. fusiformis (on pearl millet, buffel grass), C. paspali (on dallis grass), and C. africana. C. purpurea can affect a number of cereals including rye (its most common host), triticale, wheat and barley. It affects oats only rarely.
There are three races or varieties of C. purpurea, differing in their host specificity :
- G1  land grasses of open meadows and fields;
- G2  grasses from moist, forest, and mountain habitats;
- G3 (C. purpurea var. spartinae)  salt marsh grasses (Spartina, Distichlis).

# Life cycle of the fungus
An ergot kernel called a sclerotium develops when a floret of flowering grass or cereal is infected by a spore of Claviceps  fungus. The infection process mimics a pollen grain growing into an ovary during fertilization. The fungus then destroys the plant ovary and attaches itself to a vascular bundle originally intended for seed nutrition. The first stage of ergot infection manifests itself as a white soft tissue (known as sphacelia) producing sugary honeydew, which often drops out of the grass florets. This honeydew contains millions of asexual spores (conidia) which are dispersed to other florets by insects. Later, the sphacelia convert into a hard dry sclerotium inside the husk of the floret. At this stage, alkaloids and lipids accumulate in the sclerotium.
Claviceps  species from tropic and subtropic regions produce macro- and microconidia in their honeydew. Macroconidia differ in shape and size between the species, whereas microconidia are rather uniform, oval to globose (5x3m). Macroconidia are able to produce secondary conidia. A germ tube emerges from a macroconidium through the surface of a honeydew drop and a secondary conidium of the oval to pearlike shape is formed to which the contents of the original macroconidium migrates. Secondary conidia form white frost-like surface on honeydew drops and are spread by wind. No such process occurs in Claviceps purpurea, Claviceps grohii, Claviceps nigricans, and Claviceps zizaniae, all from North temperate regions.
When a mature sclerotium drops to the ground, the fungus remains dormant until proper conditions trigger its fruiting phase (onset of spring, rain period, etc.). It germinates, forming one or several fruiting bodies with head and stipe, variously colored (resembling a tiny mushroom). In the head, threadlike sexual spores are formed, which are ejected simultaneously, when suitable grass hosts are flowering. Ergot infection causes a reduction in the yield and quality of grain and hay produced, and if infected grain or hay is fed to livestock it may cause a disease called ergotism.
Black and protruding sclerotia of C. purpurea are well known. However, many tropical ergots have brown or greyish sclerotia, mimicking the shape of the host seed. For this reason, the infection is often overlooked.

# Effects on humans and animals
The ergot sclerotium contains high concentrations (up to 2% of dry mass) of ergotamine, a complex molecule consisting of a tripeptide-derived cyclol-lactam ring connected via amide linkage to a lysergic acid (ergoline) moiety, and other alkaloids of the ergoline group that are biosynthesized by the fungus. Ergot alkaloids have a wide range of biological activities including effects on circulation and neurotransmission. 
Ergotism is the name for sometimes severe pathological syndromes affecting humans or animals that have ingested ergot alkaloid-containing plant material, such as ergot-contaminated grains. The common name for ergotism is "St. Anthony's fire" referring to the symptoms, such as severe burning sensations in the limbs. These are caused by effects of ergot alkaloids on the vascular system due to vasoconstriction of blood vessels, sometimes leading to gangrene and loss of limbs due to severely restricted blood circulation. The neurotropic activities of the ergot alkaloids may also cause hallucinations and attendant irrational behaviour, convulsions, and even death.  Other symptoms include strong uterine contractions, nausea, seizures, and unconsciousness. Monks of the order of St. Anthony the Great specialized in treating ergotism victims with balms containing tranquilizing and blood circulation-stimulating plants; they were also skilled in amputations.
In addition to ergot alkaloids, Claviceps paspali also produces tremorgens (paspalitrem) causing "paspalum staggers" in cattle. Ergot alkaloids are also produced by fungi of the genera Penicillium and Aspergillus, notably by some isolates of the human pathogen Aspergillus fumigatus , and have been isolated from plants in the family Convolvulaceae, of which morning glory is best known.
Historically, controlled doses of ergot were used to induce abortions and to stop maternal bleeding after childbirth, but simple ergot extract is no longer used as a pharmaceutical. 
Ergot contains no lysergic acid diethylamide (LSD) but instead contains ergotamine which is used to synthesize lysergic acid which is then used for lysergic acid diethylamide synthesis. Moreover, lysergic acid, a molecule used in the synthesis of LSD, can be isolated from ergot.
In the January 4, 2007 edition of the New England Journal of Medicine, a paper was published documenting a British study of over 11,000 Parkinson's Disease patients, which found that two commonly used Parkinson's drugs derived from ergot, Pergolide and Cabergoline, may increase the risk of leaky heart valves by up to 700%.

# Speculations
The disease cycle of the ergot fungus was first described in the 1800s, but the connection with ergot and epidemics among people and animals was known several hundred years before that.
Human poisoning due to the consumption of rye bread made from ergot-infected grain was common in Europe in the Middle Ages. The epidemic was known as St. Anthony's Fire or ignis sacer.
It has also been posited  though speculatively  that the Salem Witch Trials were initiated by young women who had consumed ergot-tainted rye. The Great Fear in France during the Revolution has also been linked by some historians to the influence of ergot.
British author John Grigsby claims that the presence of ergot in the stomachs of some of the so called 'bog-bodies' - Iron Age human remains from peat bogs N E Europe such as Tollund man - reveals that ergot was once a ritual drink in a prehistoric fertility cult akin to that at Eleusis in Greece. In his book Beowulf and Grendel he argues that the Anglo-Saxon poem Beowulf is based on a memory of the quelling of this fertility cult by followers of Odin. He states that Beowulf, meaning barley-wolf, suggests a connection to ergot which in German was known as the 'tooth of the wolf'.
Poisonings due to consumption of seeds treated with mercury compounds are sometimes misidentified as ergotism, such as the case of mass-poisoning in the French village Pont-Saint-Esprit in 1951:
The mass poisoning which took place in the French town of Pont-St. Esprit in 1951 has been widely presented in the lay and scientific press as an example of ergotism. While the poisoning was traced to bread, ergotism was not the cause of the syndrome, which was due to a toxic mercury compound used to disinfect grain to be planted as seed. Some sacks of grain treated with the fungicide were inadvertently ground into flour and baked into bread. Albert Hofmann arrived at this conclusion after visiting Pont-St. Esprit, and analyzing samples of the bread (which contained no ergot alkaloids) and autopsy samples of four of the victims who succumbed (Hofmann 1980; Hofmann 1991). On the other hand, Swedish toxicologist Bo Holmstedt insists the poisoning was in fact due to ergotism (Holmstedt 1978)....
As Dr. Simon Cotton (member of the Chemistry Department of Uppingham School, U.K.) notes, there have been numerous cases of mass-poisoning due to consumption of mercury-treated seeds:
More horrifying than this were epidemics of poisoning, caused by people eating treated seed grains. There was a serious epidemic in Iraq in 1956 and again in 1960, whilst use of seed wheat (which had been treated with a mixture of C2H5HgCl and C6H5HgOCOCH3) for food, caused the poisoning of about 100 people in West Pakistan in 1961. Another outbreak happened in Guatemala in 1965. Most serious was the disaster in Iraq in 19712, when according to official figures 459 died. Grain had been treated with methyl mercury compounds as a fungicide and should have been planted. Instead it was sold for milling and made into bread. It had been dyed red as a warning and also had warning labels in English and Spanish that no one could understand.
Kykeon, the beverage consumed by participants in the ancient Greek mystery of Eleusinian Mysteries, might have been based on hallucinogens from ergot.
Currently, rye grain is infected repeatedly to produce ergot.