Ivabradine

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# Overview
Ivabradine is a hyperpolarization-activated cyclic nucleotide-gated channel blocker that is FDA approved for the prevention of hospitalization for worsening heart failure in patients with stable, symptomatic chronic heart failure with left ventricular ejection fraction  35%, who are in sinus rhythm with resting heart rate  70 beats per minute and either are on maximally tolerated doses of beta-blockers or have a contraindication to beta-blocker use.   Common adverse reactions include bradycardia, hypertension, atrial fibrillation and luminous phenomena (phosphenes) (  1%).

# Adult Indications and Dosage

## FDA-Labeled Indications and Dosage (Adult)
There is limited information regarding Ivabradine FDA-Labeled Indications and Dosage (Adult) in the drug label.

## Off-Label Use and Dosage (Adult)

# Pediatric Indications and Dosage

## FDA-Labeled Indications and Dosage (Pediatric)
There is limited information regarding Ivabradine FDA-Labeled Indications and Dosage (Pediatric) in the drug label.

## Off-Label Use and Dosage (Pediatric)

# Contraindications
There is limited information regarding Ivabradine Contraindications in the drug label.

# Warnings
There is limited information regarding Ivabradine Warnings' in the drug label.

# Adverse Reactions

## Clinical Trials Experience
There is limited information regarding Ivabradine Clinical Trials Experience in the drug label.

## Postmarketing Experience
There is limited information regarding Ivabradine Postmarketing Experience in the drug label.

# Drug Interactions
There is limited information regarding Ivabradine Drug Interactions in the drug label.

# Use in Specific Populations

### Pregnancy
Pregnancy Category (FDA): 
There is no FDA guidance on usage of Ivabradine in women who are pregnant.
Pregnancy Category (AUS): 
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Ivabradine in women who are pregnant.

### Labor and Delivery
There is no FDA guidance on use of Ivabradine during labor and delivery.

### Nursing Mothers
There is no FDA guidance on the use of Ivabradine in women who are nursing.

### Pediatric Use
There is no FDA guidance on the use of Ivabradine in pediatric settings.

### Geriatic Use
There is no FDA guidance on the use of Ivabradine in geriatric settings.

### Gender
There is no FDA guidance on the use of Ivabradine with respect to specific gender populations.

### Race
There is no FDA guidance on the use of Ivabradine with respect to specific racial populations.

### Renal Impairment
There is no FDA guidance on the use of Ivabradine in patients with renal impairment.

### Hepatic Impairment
There is no FDA guidance on the use of Ivabradine in patients with hepatic impairment.

### Females of Reproductive Potential and Males
There is no FDA guidance on the use of Ivabradine in women of reproductive potentials and males.

### Immunocompromised Patients
There is no FDA guidance one the use of Ivabradine in patients who are immunocompromised.

# Administration and Monitoring

### Administration
There is limited information regarding Ivabradine Administration in the drug label.

### Monitoring
There is limited information regarding Ivabradine Monitoring in the drug label.

# IV Compatibility
There is limited information regarding the compatibility of Ivabradine and IV administrations.

# Overdosage
There is limited information regarding Ivabradine overdosage.  If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

# Pharmacology
There is limited information regarding Ivabradine Pharmacology in the drug label.

## Mechanism of Action
There is limited information regarding Ivabradine Mechanism of Action in the drug label.

## Structure
There is limited information regarding Ivabradine Structure in the drug label.

## Pharmacodynamics
There is limited information regarding Ivabradine Pharmacodynamics in the drug label.

## Pharmacokinetics
There is limited information regarding Ivabradine Pharmacokinetics in the drug label.

## Nonclinical Toxicology
There is limited information regarding Ivabradine Nonclinical Toxicology in the drug label.

# Clinical Studies
There is limited information regarding Ivabradine Clinical Studies in the drug label.

# How Supplied
There is limited information regarding Ivabradine How Supplied in the drug label.

## Storage
There is limited information regarding Ivabradine Storage in the drug label.

# Images

## Drug Images

## Package and Label Display Panel

# Patient Counseling Information
There is limited information regarding Ivabradine Patient Counseling Information in the drug label.

# Precautions with Alcohol
Alcohol-Ivabradine interaction has not been established. Talk to your doctor regarding the effects of taking alcohol with this medication.

# Brand Names
There is limited information regarding Ivabradine Brand Names in the drug label.

# Look-Alike Drug Names
There is limited information regarding Ivabradine Look-Alike Drug Names in the drug label.

# Drug Shortage Status

# Price