Balance disorder

# Overview
Balance is the result of a number of body systems working together. Specifically, in order to achieve balance the eyes (visual system), ears (vestibular system) and the body's sense of where it is in space (proprioception) need to be intact. Also the brain, which compiles this information, needs to be functioning normally. The balance system works with the visual and skeletal systems (the muscles and joints and their sensors) to maintain orientation or balance. For example, visual signals are sent to the brain about the body's position in relation to its surroundings. These signals are processed by the brain, and compared to information from the vestibular, visual and the skeletal systems.

# Normal Balance Functioning
The semicircular canals, found within the vestibular apparatus, let us know when we are in a rotary (circular) motion. The semicircular canals are fluid-filled. Motion of the fluid tells us if we are moving.  The vestibule is the region of the inner ear where the semicircular canals converge, close to the cochlea (the hearing organ). The vestibular system works with the visual system to keep objects in focus when the head is moving.  This is called the vestibulo-ocular reflex (VOR).
Movement of fluid in the semicircular canals signals the brain about the direction and speed of rotation of the head - for example, whether we are nodding our head up and down or looking from right to left. Each semicircular canal has a bulbed end, or enlarged portion, that contains hair cells. Rotation of the head causes a flow of fluid, which in turn causes displacement of the top portion of the hair cells that are embedded in the jelly-like cupula. Two other organs that are part of the vestibular system are the utricle and saccule. These are called the otolithic organs and are responsible for detecting linear acceleration, or movement in a straight line. The hair cells of the otolithic organs are blanketed with a jelly-like layer studded with tiny calcium stones called otoconia. When the head is tilted or the body position is changed with respect to gravity, the displacement of the stones causes the hair cells to bend.

# Disordered Balance
Problems with balance occur whenever there is a disruption in any of the vestibular, visual, proprioceptive or cognitive systems. Symptoms of a balance disorder may include dizziness, vertigo (spinning), disequilibrium (off balance and falls), pre-syncope (light headedness).  Abnormalities in balance function may indicate a wide range of pathologies from causes like low blood pressure to stroke or brain tumors.
Many different terms are often used to describe what is collectively known as dizziness.  Common descriptions include words such as lightheaded, floating, whoozy, giddy, confused, helpless or fuzzy.  Vertigo, Disequilibrium and Pre-syncope are the terms in use by  most doctors.
Vertigo
Vertigo is a specific medical term used to describe the sensation of spinning or having the room spin about you. Most people find vertigo very disturbing and report associated nausea and vomiting.
Disequilibrium
Disequilibrium is the sensation of being off balance, and is most often characterized by frequent falls in a specific direction.  This condition is not often associated with nausea or vomiting.
Pre-syncope
Pre-syncope is most often described as lightheaded or feeling faint.  Syncope, by contrast, is actually fainting.

# Types of Balance Problems

## Related to the Ear
Causes of dizziness related to the ear are often characterized by vertigo (spinning) and nausea.  Nystagmus (flickering of the eye, related to the VOR) is often seen in patients with an acute peripheral cause of dizziness.
- Benign Paroxysmal Positional Vertigo (BPPV) - The most common cause of vertigo.  Typically described as a brief, intense sensation of spinning that occurs because of a specific change in the position of head. An individual may experience BPPV when rolling over to the left or right, upon getting out of bed in the morning, or when looking up for an object on a high shelf. The cause of BPPV is the presence of normal but misplaced crystals called otoconia.  Otoconia are normally found in the utricle and saccule and are used to sense movement. When loose in the semicircular canals, they can distort the sense of movement, causing a mismatch between actual head movement and the information sent to the brain by the inner ear, this is interpreted as spinning.
- Labyrinthitis - An inner ear infection or inflammation causing both dizziness (vertigo) and hearing loss.
Vestibular neuronitis - an infection of the vestibular nerve, generally viral, causing vertigo
Cochlear neuronitis - an infection of the cochlear nerve, generally viral, causing sudden deafness but no vertigo
- Vestibular neuronitis - an infection of the vestibular nerve, generally viral, causing vertigo
- Cochlear neuronitis - an infection of the cochlear nerve, generally viral, causing sudden deafness but no vertigo
- Trauma - Injury to the skull may cause either a fracture or a concussion to the organ of balance. In either case an acute head injury will often result in dizziness and a sudden loss of vestibular function.
- Meniere's disease - an inner ear fluid balance disorder that causes lasting episodes of vertigo, fluctuating hearing loss, tinnitus (a ringing or roaring in the ears), and the sensation of fullness in the ear. The cause of Meniere's disease is unknown.
- Perilymph fistula - a leakage of inner ear fluid from the inner ear. It can occur after head injury, surgery, physical exertion or without a known cause.

## Related to the Brain
Brain related causes are less commonly associated with isolated vertigo and nystagmus but can still produce signs and symptoms which mimic peripheral causes.  Disequilibrium is often a prominent feature.
- Degenerative: Age related decline in balance function
- Infectious: Meningitis, encephalitis, epidural abscess, Syphilis
- Circulatory: Cerebral or Cerebellar ischemia or hypoperfusion, Stroke, Wallenberg lateral medullary syndrome
- Autoimmune: Cogan syndrome
- Structural: Arnold-Chiari malformation, Hydrocephalus
- Systemic: Multiple Sclerosis, Parkinsons
- CNS or Posterior Neoplasms: Benign or Malignant
- Other - There are a host of other causes of dizziness not related to the ear.
Mal de Debarquement is rare disorder of imbalance caused by being on board a ship.  Patients suffering from this condition feel sea sick even when they get off the ship.
Motion Sickness - a conflict between the input from the various systems involved in balance causes an unpleasant sensation.  For this reason looking out the window of a moving car is much more pleasant than looking inside the vehicle.
Toxins, drugs, medications
- Mal de Debarquement is rare disorder of imbalance caused by being on board a ship.  Patients suffering from this condition feel sea sick even when they get off the ship.
- Motion Sickness - a conflict between the input from the various systems involved in balance causes an unpleasant sensation.  For this reason looking out the window of a moving car is much more pleasant than looking inside the vehicle.
- Toxins, drugs, medications

# Symptoms
When balance is impaired, an individual has difficulty maintaining orientation. For example, an individual may experience the "room spinning" and may not be able to walk without staggering, or may not even be able to stand. Some of the symptoms a person with a balance disorder may experience are:
- A sensation of dizziness or vertigo.
- Falling or a feeling of falling.
- Lightheadedness or feeling woozy.
- Problems reading and difficulty seeing.
- Disorientation.
Some individuals may also experience nausea and vomiting, diarrhea, faintness, changes in heart rate and blood pressure, fear, anxiety, or panic. Some reactions to the symptoms are fatigue, depression, and decreased concentration. The symptoms may appear and disappear over short time periods or may last for a longer period of time.
Cognitive dysfunction (disorientation) is often seen with vestibular disorders.  Cognitive deficits are not just spatial in nature, but also include non-spatial functions such as object recognition memory. Vestibular dysfunction has been shown to adversely affect attentional processes and increased attentional demands can worsen the postural sway associated with vestibular disorders. Recent MRI studies also show that humans with bilateral vestibular damage undergo atrophy of the hippocampus which correlates with their degree of impairment on spatial memory tasks.

# Diagnosis
Diagnosis of a balance disorder is complicated because there are many kinds of balance disorders and because other medical conditions  including ear infections, blood pressure changes, and some vision problems  and some medications may contribute to a balance disorder. A person experiencing dizziness should see a physician for an evaluation. Once diagnosed with, or cleared of a medical disorder, a physiotherapist can assess balance in detail.
The primary physician may request the opinion of an otolaryngologist to help evaluate a balance problem. An otolaryngologist is a physician/surgeon who specializes in diseases and disorders of the ear, nose, throat, head, and neck, sometimes with expertise in balance disorders. He or she will usually obtain a detailed medical history and perform a physical examination to start to sort out possible causes of the balance disorder. The physician may require tests and make additional referrals to assess the cause and extent of the disruption of balance. The kinds of tests needed will vary based on the patient's symptoms and health status. Because there are so many variables, not all patients will require every test.

## Diagnostic Testing
Tests of vestibular system (balance) function include electronystagmography (ENG), Videonystagmograph (VNG), rotation tests, Computerized Dynamic Posturography (CDP), and Caloric reflex test.
Tests of auditory system (hearing) function include pure-tone audiometry, speech audiometry, acoustic-reflex, electrocochleography (ECoG), otoacoustic emissions (OAE), and auditory brainstem response test (ABR; also known as BER, BSER, or BAER).
Other diagnostic tests include magnetic resonance imaging (MRI) and computerized axial tomography (CAT, or CT).

# Treatment
There are various options for treating balance disorders. One option includes treatment for a disease or disorder that may be contributing to the balance problem, such as ear infection, stroke, or multiple sclerosis. Individual treatment will vary and will be based upon symptoms, medical history, general health, examination by a physician, and the results of medical tests.  Most types of balance disorders will require balance training, prescribed by a physiotherapist.

## BPPV
Benign Paroxysmal Positional Vertigo (BPPV) is caused by misplaced crystals within the ear.  Treatment, simply put, involves moving these crystals out of areas which cause vertigo and into areas where they do not.  A number of exercises have been developed to shift these crystals. The following article explains with diagrams how these exercises can be performed at the office or at home with some help:   The success of these exercises depends on them being performed correctly.
The two exercises explained in the above article are:
- The Brandt-Daroff Exercises, which can be done at home and have a very high success rate but are unpleasant and time consuming to perform.
- The Epley Exercises, which are often performed by a doctor but can be performed at home with some assistance.

## Meniere's disease
- Diet: Dietary changes such as reducing intake of sodium (salt) may help. For some people, reducing alcohol, caffeine, and/or avoiding nicotine may be helpful. Stress has also been shown to make the symptoms associated with meniere's worse
- Drugs:
Beta-histine (Serc) is available in some countries and is thought to reduce the frequency of symptoms
Diuretics such as hydrochlorohyiazide (Diazide)have also been shown to reduce the frequency of symptoms
Aminoglycoside antibiotics (gentamicin) can used to treat Meniere's disease. Systemic streptomycin (given by injection) and topical gentamicin (given directly to the inner ear) are useful for their ability to affect the hair cells of the balance system. Gentamicin also can affect the hair cells of the cochlea, though, and cause hearing loss in about 10% of patients. In cases that do not respond to medical management, surgery may be indicated.
- Beta-histine (Serc) is available in some countries and is thought to reduce the frequency of symptoms
- Diuretics such as hydrochlorohyiazide (Diazide)have also been shown to reduce the frequency of symptoms
- Aminoglycoside antibiotics (gentamicin) can used to treat Meniere's disease. Systemic streptomycin (given by injection) and topical gentamicin (given directly to the inner ear) are useful for their ability to affect the hair cells of the balance system. Gentamicin also can affect the hair cells of the cochlea, though, and cause hearing loss in about 10% of patients. In cases that do not respond to medical management, surgery may be indicated.
- Surgery for meniere's disease is a last resort
Vestibular neuronectomy can cure Meniere's disease but is very involved surgery and not widely available. It involves drilling into the skull and cutting the balance nerve just as it is about to enter the brain.
Labyrinthectomy (surgical removal of the whole balance organ)is more widely available as a treatment but causes total deafness in the affected ear.
- Vestibular neuronectomy can cure Meniere's disease but is very involved surgery and not widely available. It involves drilling into the skull and cutting the balance nerve just as it is about to enter the brain.
- Labyrinthectomy (surgical removal of the whole balance organ)is more widely available as a treatment but causes total deafness in the affected ear.

## Labyrinthitis
Treatment includes balance retraining exercises (vestibular rehabilitation). The exercises include movements of the head and body specifically developed for the patient. This form of therapy is thought to promote compensation for the disorder. Vestibular retraining programs are administered by professionals with knowledge and understanding of the vestibular system and its relationship with other systems in the body.

# Medical Therapy
Sedative drugs are often prescribed for vertigo and dizziness, but these usually treat the symptoms rather than the underlying cause. Lorazepam (ativan) is often used and is a sedative which has no effect on the disease process rather helps patients cope with the sensation.
Anti-nauseants, like those prescribed for motion sickness, are also often prescribed but do not effect the prognosis of the disorder.
Specifically for meniere's disease a medication called Serc (Beta-histine) is available.  There is some evidence to support it is effective to reduce the frequency of attacks.  Also Diuretics, like Diazide (HCTZ/triamterene), are effective in many patients.  Finally, ototoxic medications delivered either systemically or through the eardrum can eliminate the vertigo associated with Meniere's in many cases, although there is about a 10% risk of further hearing loss when using ototoxic medications.
Treatment is specific for underlying disorder of balance disorder:
- anticholinergics
- antihistamines
- benzodiazepines
- calcium channel antagonists, specifically Verapamil and Nimodipine
- GABA modulators, specifically gabapentin and baclofen
- Neurotransmitter reuptake inhibitors such as SSRI's, SNRI's and Tricyclics

# Research
Scientists at the National Institute on Deafness and Other Communication Disorders (NIDCD) are working to understand the various balance disorders and the complex interactions between the labyrinth, other balance-sensing organs, and the brain. NIDCD scientists are studying eye movement to understand the changes that occur in aging, disease, and injury, as well as collecting data about eye movement and posture to improve diagnosis and treatment of balance disorders. They are also studying the effectiveness of certain exercises as a treatment option.
Other projects supported by the NIDCD include studies of the genes essential to normal development and function in the vestibular system. NIDCD scientists are also studying inherited syndromes of the brain that affect balance and coordination.
The NIDCD supports research to develop new tests and refine current tests of balance and vestibular function. For example, NIDCD scientists have developed computer-controlled systems to measure eye movement and body position by stimulating specific parts of the vestibular and nervous systems. Other tests to determine disability, as well as new physical rehabilitation strategies, are under investigation in clinical and research settings.
Scientists at the NIDCD hope that new data will help to develop strategies to prevent injury from falls, a common occurrence among people with balance disorders, particularly as they grow older.

# Source
This article is adapted from the public domain article at