Cotard delusion

# Overview
The Cotard delusion or Cotard's syndrome, also known as nihilistic or negation delusion, is a rare neuropsychiatric disorder in which a person holds a delusional belief that he or she is dead, does not exist, is putrefying or has lost his/her blood or internal organs.  Rarely, it can include delusions of immortality.
It is named after Jules Cotard (18401889), a French neurologist who first described the condition, which he called le delire de negation ("negation delirium"), in a lecture in Paris in 1880.
In this lecture, Cotard described a patient with the moniker of Mademoiselle X, who denied the existence of God, the Devil, several parts of her body and denied she needed to eat. Later she believed she was eternally damned and could no longer die a natural death.
Young and Leafhead (1996, p155) describe a modern-day case of Cotard delusion in a patient who suffered brain injury after a motorcycle accident:
It can arise in the context of neurological illness or mental illness and is particularly associated with depression and derealization.
Treatment is difficult, and tricyclic and serotoninergic antidepressant drugs have shown little efficacy.  Electroconvulsive therapy has shown greater promise, "curing" Cotard's sufferers in five studies of its efficacy with that treatment.

# Symptoms
Cotard described hypochondriac ideas that varied from the spontaneous destruction of different organs, the entire body, or soul to the complete denial of ones own existence as the most important characteristic elements of the syndrome. The most prominent symptoms of Cotards syndrome are depressive mood (89%), nihilistic delusions concerning ones own body (86%), nihilistic delusions concerning ones own existence (69%), anxiety (65%), delusions of guilt (63%), delusions of immortality (55%), and hypochondriac delusions (58%). Some delusions present as special forms of Cotards syndrome (eg, delusional denial of ones pregnancy despite clear morphologic signs and delusional paralysis in a patient with psychomotor agitation ). In its early course, Cotards syndrome is characterized by a vague feeling of anxiety lasting from weeks to years. The patient then further loses touch with reality . With the delusion of being dead, patients show an increased tendency toward self-mutilation or suicidal behavior.

# Treatment
Monotherapy with agents such as amitriptyline , duloxetine , fluoxetine , paroxetine , olanzapine , sulpiride, or lithium has been reported to be effective. However, combination strategies often are used (clomipramine/amitriptyline , pimozide/amitriptyline , haloperidol/clomipramine, cyamemazine/ paroxetine , risperidone/fluoxetine, haloperidol/ mirtazapine , risperidone/sertraline, risperidone/ citalopram, clozapine/fluvoxamine/imipramine). Adding bromocriptine to clomipramine and lithium had a benefi cial effect in one patient with bipolar disorder type I . ECT (Electroconvulsive therapy) is also an important treatment option in Cotards syndrome.

# Cultural references
- On episode 4.14 ("My Lucky Charm") of the television show Scrubs, a character named Jerry (played by Michael Bunin), who suffers from Cotard syndrome, complains of the hardships of being dead.
- British electronic musician Matt Elliott named a song for the condition on his 2003 album The Mess We Made.
- In the April 12, 2007 comic of Dinosaur Comics, T-Rex refers to Cotard syndrome.
- Chuck Klosterman makes reference to Jules Cotard and Cotard's syndrome in his book, Killing Yourself to Live: 85% of a True Story. The protagonist, Klosterman, feels like he might be a victim of the syndrome, especially when he is in airports.
- The characters in Peter Watts' book Blindsight experience Cotard-like symptoms as a result of the intense electromagnetic fields of the Rorschach craft.