Flutemetamol F 18

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# Overview
Flutemetamol F 18 is a Diagnostic Agent that is FDA approved for the diagnosis of Positron Emission Tomography (PET) imaging of the brain to estimate  amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer's disease (AD).   Common adverse reactions include flushing, headache, hypertension, nausea, and dizziness.

# Adult Indications and Dosage

## FDA-Labeled Indications and Dosage (Adult)

### Indications
- Vizamyl is indicated for Positron Emission Tomography (PET) imaging of the brain to estimate  amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer's Disease (AD) and other causes of cognitive decline.
- A negative Vizamyl scan indicates sparse to no neuritic plaques and is inconsistent with a neuropathological diagnosis of AD at the time of image acquisition; a negative scan result reduces the likelihood that a patient's cognitive impairment is due to AD. A positive Vizamyl scan indicates moderate to frequent amyloid neuritic plaques; neuropathological examination has shown this amount of amyloid neuritic plaque is present in patients with AD, but may also be present in patients with other types of neurologic conditions as well as in older people with normal cognition. Vizamyl is an adjunct to other diagnostic evaluations.
- A positive Vizamyl scan does not establish a diagnosis of AD or other cognitive disorder.
- Safety and effectiveness of Vizamyl have not been established for:
- Predicting development of dementia or other neurologic condition.
- Monitoring responses to therapies.

### Dosage
- Vizamyl is a radioactive drug and should be handled with safety measures to minimize radiation exposure during administration. Use waterproof gloves and effective shielding, including lead-glass syringe shields when handling and administering Vizamyl. To minimize radiation dose to the bladder, encourage patients to hydrate before and after Vizamyl administration in order to permit frequent voiding. Encourage patients to void before and after imaging with Vizamyl and frequently thereafter for 24 hours following Vizamyl administration.
- Radiopharmaceuticals, including Vizamyl, should be used by or under the control of physicians who are qualified by specific training and experienced in the safe use and handling of radioactive materials, and whose experience and training have been approved by the appropriate governmental agency authorized to license the use of radiopharmaceuticals.
- The recommended dose for Vizamyl is 185 megabecquerels (MBq)  in a maximum dose volume of 10 mL, administered as a single intravenous bolus within 40 seconds. The maximum mass dose is 20 micrograms. Follow the injection with an intravenous flush of 5 to 15 mL of 0.9% sterile sodium chloride injection.
- Use aseptic technique and radiation shielding to withdraw and administer Vizamyl solution.
- Calculate the necessary volume to administer based on calibration time and dose using a suitably calibrated instrument.
- Visually inspect Vizamyl for particulate matter and discoloration prior to administration. Do not administer Vizamyl if it contains particulate matter or is discolored.
- Do not dilute Vizamyl.
- Dispose of unused product in a safe manner in compliance with applicable regulations.
- A 20-minute PET image should be acquired starting 90 minutes after Vizamyl injection, using a PET scanner in 3-D mode with appropriate data corrections. Position the patient supine with the brain (including the cerebellum) within a single field of view. The patient's head should be tilted so that the anterior commissure-posterior commissure (AC-PC) plane is at right angles to the bore-axis of the PET scanner, with the head positioned in a suitable head support. Reducing head movement with tape or other flexible head restraints may be employed.
- Iterative or filtered back-projection reconstruction is recommended with a slice thickness of 2 to 4 mm, matrix size of 128 x 128 with pixel sizes of approximately 2 mm. Where a post-smoothing filter is applied, a full width half maximum (FWHM) of not more than 5 mm is recommended; filter FWHM should be chosen to optimize the signal-to-noise ratio while preserving the sharpness of the reconstructed image.
- Orient axial and coronal images to show symmetry of brain structures, with equal heights of structures bilaterally. Orient sagittal images so that the head and neck are neither flexed nor extended; the anterior and posterior aspects of the corpus callosum should be parallel to the AC-PC line as shown in Figure 2.
- Display images with all planes (axial, sagittal and coronal planes) linked by crosshairs.
- Select a color scale that provides a progression of low through high intensity (e.g., rainbow or Sokoloff). The selected color scale should (1) provide colors that allow the reader to discriminate intensity levels above and below the intensity level of the pons, (2) provide a color for regions with little or no amyloid binding such as the cerebellar cortex, and (3) provide a range of at least five distinct colors above 50 to 60% of the peak intensity.
- Display the reference scale. Adjust the color scale to set the pons to approximately 90% maximum intensity. The cerebellar cortex should represent approximately 20-30% of peak intensity on both negative and positive Vizamyl scans.
- Briefly display axial brain slices from bottom to top and look for signs of atrophy.
- Systematically review the following brain regions (recommended plane) for flutemetamol F18 uptake as described in Image Interpretation below:
- Frontal lobes (axial, with optional sagittal plane view)
- Posterior cingulate and precuneus (sagittal, with optional coronal plane view)
- Lateral temporal lobes (axial, with optional coronal plane view)
- Inferolateral parietal lobes (coronal, with optional axial plane view)
- Striatum (axial, with optional sagittal plane view)
Vizamyl images should be interpreted only by readers who successfully complete the electronic training program provided by the manufacturer. The objective of Vizamyl image interpretation is to provide an estimate of the brain -amyloid neuritic plaque density, not to make a clinical diagnosis. Image interpretation is performed independently of a patient's clinical features and relies upon recognition of image features in certain brain regions.
- Image interpretation is based upon the distribution of radioactive signal within the brain; clinical information is not a component of image assessment. Images are designated as positive or negative either by comparing radioactivity in cortical grey matter with activity in adjacent white matter, or based on the intensity in the five regions mentioned above. Signal uptake in the cerebellum does not contribute to scan interpretation (for example, a positive scan may show retained cerebellar grey-white contrast even when the cortical grey-white contrast is lost). Images should be viewed with the minimum image intensity set to zero and the maximum set such that the signal level in the easily identifiable pons is at 90% of maximum.
- Negative scans show more radioactivity in white matter than in grey matter, creating clear grey-white matter contrast.
- Specifically, a negative scan would have the following characteristics:
- frontal, lateral temporal, inferolateral parietal lobes: gradual gradient from bright intensity of the white matter to lower intensity at the periphery of the brain; distinct sulci with concave surfaces (white matter sulcal pattern),
and
- posterior cingulate and precuneus: grey matter uptake below 50-60% of peak intensity; gap of lower intensity separates two hemispheres on coronal view,
and
- striatum: approximately 50% of peak intensity or lower in the region between the higher intensities of the thalamus and frontal white matter (striatal "gap")
Positive scans show at least one cortical region with reduction or loss of the normally distinct grey-white matter contrast. These scans have one or more regions with increased cortical grey matter signal (above 50-60% peak intensity) and/or reduced (or absent) grey-white matter contrast (white matter sulcal pattern is less distinct). A positive scan may have one or more regions in which grey matter radioactivity is as intense or exceeds the intensity in adjacent white matter.
- Specifically, a positive scan would have the following characteristics:
- frontal, lateral temporal, or inferolateral parietal lobes: high intensity seen to the periphery of the brain, with sharp reduction of intensity at the brain margin; sulci not distinct due to fill-in by high intensity grey matter resulting in a convex surface at the edge of the brain,
-r
- posterior cingulate and precuneus: grey matter uptake above 50-60% of peak intensity; high grey matter intensity that closes the gap between the two hemispheres on coronal view,
-r
- striatum: intensity above 50-60% of peak intensity; gap between thalamus and frontal white matter not distinct
- If any one of the brain regions systematically reviewed for flutemetamol F18 uptake is positive in either hemisphere, then the scan is considered positive. Otherwise, the scan is considered negative.
- Among patients with clinically important -amyloid neuritic plaques in the brain, the temporal lobes, parietal lobes, and striatum may not be as affected compared to other brain regions. Therefore, in some images, flutemetamol F18 signal in these regions may not be as intense as in the frontal lobes or the posterior cingulate and precuneus regions.
- Atrophy may affect the interpretability of scans, particularly in the frontal, temporal and parietal lobe. For cases in which atrophy is apparent or suspected and there is uncertainty as to the location of the grey matter on the PET scan, examine the striatum for flutemetamol F18 signal as it is less affected by atrophy than other regions of the brain.
- If the patient's MRI or CT brain images are available the interpreter should examine the CT or MRI images to clarify the relationship between PET flutemetamol F18 uptake and grey matter anatomy.
- Other factors that may affect the ability to interpret Vizamyl images include patient factors such as brain pathology, surgical changes, post-radiation therapy changes, and implants. Some scans may be difficult to interpret due to image noise, suboptimal patient positioning, or over-smoothing of the reconstructed image.
- Figure 1: Axial view of negative (left) and positive (right) Vizamyl scans. The axial slices which cut through the frontal pole and inferior aspect of the splenium are shown using a rainbow color scale. The left image shows a white matter sulcal pattern at the frontal (f) and lateral temporal (lt) regions with a color intensity that tapers to the periphery, as well as less radioactivity in the striatal region(s). The right image shows absence of the white matter sulcal pattern with intensity radiating to a sharply defined convex edge, as well as more radioactivity in the striatum. In both the frontal and lateral temporal regions, the intensity is higher in the grey matter regions of the right image compared to those of the left image.

## Off-Label Use and Dosage (Adult)

### Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Flutemetamol F 18 in adult patients.

### NonGuideline-Supported Use
There is limited information regarding Off-Label NonGuideline-Supported Use of Flutemetamol F 18 in adult patients.

# Pediatric Indications and Dosage

## FDA-Labeled Indications and Dosage (Pediatric)
Safety and efficacy has not been established in pediatrics patient.

## Off-Label Use and Dosage (Pediatric)

### Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Flutemetamol F 18 in pediatric patients.

### NonGuideline-Supported Use
There is limited information regarding Off-Label NonGuideline-Supported Use of Flutemetamol F 18 in pediatric patients.

# Contraindications
- Vizamyl is contraindicated in patients with a history of hypersensitivity reaction to Vizamyl, polysorbate 80, or any other inactive ingredient in Vizamyl

# Warnings
- Hypersensitivity reactions such as flushing and dyspnea have been observed within minutes following Vizamyl administration. These reactions may occur in patients with no history of prior exposure to Vizamyl.
- Before administering Vizamyl, ask patients about prior reactions to drugs, especially those containing polysorbate 80.
- Have resuscitation equipment and trained personnel immediately available at the time of Vizamyl administration .
- Errors may occur while using Vizamyl PET images to estimate brain neuritic plaque density.
- Image interpretation is performed independently of the patient's clinical information. The use of clinical information in the interpretation of Vizamyl images has not been evaluated and may lead to errors. Extensive brain atrophy may limit the ability to distinguish grey and white matter on a Vizamyl scan. Motion artifacts may distort the image.
- Vizamyl scan results are indicative of the brain neuritic amyloid plaque content only at the time of image acquisition and a negative scan result does not preclude the development of brain amyloid in the future.
- Vizamyl, similar to other radiopharmaceuticals, contributes to a patient's overall long-term cumulative radiation exposure. Long-term cumulative radiation exposure is associated with an increased risk of cancer. Ensure safe handling to protect patients and health care workers from unintentional radiation exposure

# Adverse Reactions

## Clinical Trials Experience
- Clinical trials are conducted under widely varying conditions and adverse reaction rates observed in the clinical trials of Vizamyl cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.
- In clinical trials, 761 adults (367 men and 394 women, 91% Caucasian) with a mean age of 62 years (range 18-93 years) received Vizamyl. Most subjects (530, 70%) received a dose of 185 MBq (5 mCi).
- One subject out of 761 administered Vizamyl experienced a serious hypersensitivity reaction with flushing, dyspnea and chest pressure within minutes following Vizamyl administration and recovered with treatment.
- Most adverse reactions were mild to moderate in intensity and resolved spontaneously. The most commonly reported adverse reactions (occurring in at least 1% of subjects) in Vizamyl-treated subjects are shown in Table 2.

## Postmarketing Experience
There is limited information regarding Postmarketing Experience of Flutemetamol F 18 in the drug label.

# Drug Interactions
- Pharmacodynamic drug-drug interaction studies have not been performed in patients to establish the extent, if any, to which concomitant medications may alter Vizamyl image results.
- Within a clinical study of patients with a range of cognitive impairment, some patients were receiving the following medications: donepezil, galantamine, memantine, rivastigmine. Mean cortical Standardized Uptake Value (SUV) ratios did not differ between the patients taking or not taking these concomitant medications.

# Use in Specific Populations

### Pregnancy
Pregnancy Category (FDA): C
- It is not known whether Vizamyl can cause fetal harm when administered to a pregnant woman or if it can affect reproduction capacity. Animal reproduction studies have not been conducted with Vizamyl. All radiopharmaceuticals, including Vizamyl, have the potential to cause fetal harm. The likelihood of fetal harm depends on the stage of fetal development, and the magnitude of the radiopharmaceutical dose. Vizamyl should be given to a pregnant woman only if clearly needed. Assess pregnancy status before administering Vizamyl to a female of reproductive potential.
Pregnancy Category (AUS):
- Australian Drug Evaluation Committee (ADEC) Pregnancy Category
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Flutemetamol F 18 in women who are pregnant.

### Labor and Delivery
There is no FDA guidance on use of Flutemetamol F 18 during labor and delivery.

### Nursing Mothers
- It is not known whether flutemetamol is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for radiation exposure to nursing infants from Vizamyl, avoid use of the drug in a breastfeeding mother or have the mother temporarily interrupt breastfeeding for 24 hours (greater than 10 half-lives of radioactive decay for the F 18 isotope) after exposure to Vizamyl. If breastfeeding is interrupted, the patient should pump and discard her breast milk and use alternate infant nutrition sources (e.g., stored breast milk or infant formula) for 24 hours after administration of the drug.

### Pediatric Use
- Vizamyl is not indicated for use in pediatric patients.

### Geriatic Use
- Of the 761 subjects in clinical studies of Vizamyl, 447 (59%) were 65 years or over, while 246 (32%) were 75 years or over. No overall differences in safety were observed between these subjects and younger subjects.

### Gender
There is no FDA guidance on the use of Flutemetamol F 18 with respect to specific gender populations.

### Race
There is no FDA guidance on the use of Flutemetamol F 18 with respect to specific racial populations.

### Renal Impairment
There is no FDA guidance on the use of Flutemetamol F 18 in patients with renal impairment.

### Hepatic Impairment
There is no FDA guidance on the use of Flutemetamol F 18 in patients with hepatic impairment.

### Females of Reproductive Potential and Males
There is no FDA guidance on the use of Flutemetamol F 18 in women of reproductive potentials and males.

### Immunocompromised Patients
There is no FDA guidance one the use of Flutemetamol F 18 in patients who are immunocompromised.

# Administration and Monitoring

### Administration
- Intravenous

### Monitoring
There is limited information regarding Monitoring of Flutemetamol F 18 in the drug label.

# IV Compatibility
There is limited information regarding IV Compatibility of Flutemetamol F 18 in the drug label.

# Overdosage
- The clinical consequence of overdose with Vizamyl has not been reported. It is unknown whether or not flutemetamol is dialyzable. The major risks of overdose relate predominantly to increased radiation exposure, with long-term risks for neoplasia. In case of overdose of radioactivity, hydration and frequent urination should be encouraged to minimize radiation exposure to the patient; care should be taken to avoid contamination from the radioactivity eliminated by the patient.

# Pharmacology
Flutemetamol (18F) (trade name Vizamyl, by GE Healthcare) is a PET scanning radiopharmaceutical containing the radionuclide fluorine-18, used as a diagnostic tool for Alzheimer's disease.

## Mechanism of Action
- Flutemetamol F 18 binds to -amyloid plaques in the brain and the F-18 isotope produces a positron signal that is detected by a PET scanner. In in vitro binding studies using postmortem human brain homogenates containing fibrillar -amyloid, the dissociation constant (Kd) for flutemetamol was 6.7 nM.
- Selectivity of flutemetamol binding in post-mortem human brain sections was demonstrated using autoradiography, silver-stained protein, and immunohistochemistry (monoclonal antibody to -amyloid) correlation studies.

## Structure
- Vizamyl contains flutemetamol F 18, a molecular imaging agent that binds to -amyloid aggregates, and is intended for use with PET imaging of the brain. Chemically, flutemetamol F 18, is described as 2-fluoro-4-(methylamino) phenyl]-6-benzothiazolol. It has the molecular formula C14H1118FN2OS, molecular weight 273.32, and the following structural formula:
- Vizamyl is a sterile, non-pyrogenic, clear, colorless to slightly yellow radioactive solution for intravenous injection. Each milliliter (mL) of the no-carrier added Vizamyl product solution contains 150 MBq (4.05 mCi) of flutemetamol F 18 at reference date and time and up to 2 micrograms of flutemetamol. Each mL of the Vizamyl solution also contains 70 microliters ethanol, 9.0 mg sodium chloride and 4.98 mg polysorbate 80 (w/v) in 0.014 M aqueous phosphate buffer. The pH of the solution is between 6.0 and 8.5.

## Pharmacodynamics
- Following intravenous injection, flutemetamol F 18 diffuses across the human blood-brain barrier and produces a radioactivity signal detectable throughout the brain. Subsequently, cerebral perfusion decreases the brain flutemetamol F 18 content, with differential retention of the drug in cortical areas that contain -amyloid aggregates compared to areas that lack the aggregates. The time-activity curves for flutemetamol F 18 in the brain of subjects with positive scans shows continual signal increases from time zero through 30 minutes post administration, with stable values thereafter up to at least 120 minutes post-injection. Differences in signal intensity between brain regions that specifically retain flutemetamol F 18 and brain regions with nonspecific retention of the drug form the basis of image interpretation methods.
- The test-retest distribution of flutemetamol F 18 was evaluated in 5 subjects with probable AD who underwent two administrations of flutemetamol F 18 (followed by PET scans) separated by a time period of 1 to 4 weeks. Images were reproducible when evaluated semi-quantitatively using an automated assessment of SUV in pre-specified cortical regions of brain.

## Pharmacokinetics
- Following intravenous injection of 185 MBq (5 mCi) of Vizamyl in humans, flutemetamol F 18 plasma concentrations declined by approximately 75% in the first 20 minutes post-injection, and by approximately 90% in the first 180 minutes. The F 18 in circulation during the 30-120 minutes imaging window in plasma was principally associated with flutemetamol metabolites. Excretion was approximately 37% renal (28-45%; n=6) and 52% hepatobiliary (40-65%; n=6).

## Nonclinical Toxicology
- Animal studies have not been performed to evaluate the carcinogenicity potential of flutemetamol. Flutemetamol was positive for mutagenicity in two in vitro assays: the bacterial reverse mutation assay (Ames test) and the mouse lymphoma assay.
- Flutemetamol was negative for genotoxicity after in vivo exposure in rats to flutemetamol at the highest cumulative dose level tested, as measured in bone marrow micronucleus assays (157 and 27 microgram/kg/day for 2 and 14 days respectively) and an unscheduled DNA synthesis assay in rat hepatocytes (39 microgram/kg/day).

# Clinical Studies
- Vizamyl was evaluated in two clinical studies (Study One and Study Two) in adult subjects with a range of cognitive function, including some terminally ill patients who had agreed to participate in a post-mortem brain donation program. Both studies were single-arm and subjects underwent Vizamyl injection and scan. The images were interpreted by five independent readers masked to all clinical information; readers in Study Two were naive to all forms of amyloid PET imaging. PET images were reviewed first without, and subsequently with, brain CT or MRI images.
- Study One evaluated pre-mortem Vizamyl PET images from terminally ill patients and compared the results to postmortem truth standard assessments of cerebral cortical neuritic plaque density in patients who died during the study. Readers evaluated images using a clinically applicable binary image interpretation method (positive/negative) that involved evaluating regional Vizamyl brain uptake to yield a final overall image assessment that was compared to the truth standard. Before image interpretation, all readers underwent in-person tutoring on image interpretation. To determine the agreement between the in vivo Vizamyl image results and the post-mortem whole brain amyloid neuritic plaque density, Vizamyl results (negative/positive) were pre-specified to correspond with specific global histopathology plaque density scores, based upon a modification of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) criteria (Table 5), which use neuritic plaque counts as a necessary pathological feature of AD. Plaques were counted on microscope slides with modified Bielschowsky silver-stained tissue sections. The global brain neuritic plaque density score for each subject was determined by averaging across the scores (0-3) for five grey matter fields per slide and then across the six slides for each of eight regions; if any one region had a regional score of greater than 1.5, the subject's brain was classified as positive for amyloid.
- In Study One, one hundred eighty patients were dosed with Vizamyl and 176 were imaged. The median patient age was 82 years (range 47 to 98 years) and 57% of the patients were female. By medical history 44 patients had no cognitive impairment, 135 had dementia, no patients had mild cognitive impairment (MCI), and one patient had memory loss of unspecified nature. Sixty-nine patients died during the study; 68 had cerebral cortical amyloid status determined (43 positive and 25 negative) and were included in the primary analysis. The time interval between the Vizamyl scan and death ranged from 0 to 13 months, with a median of 2.6 months, and was less than one year for 66 patients and between 12 to 13 months for 2 patients. At autopsy, the global brain neuritic plaque density category (CERAD classification as in Table 5) was available for 67/68 subjects: frequent (n = 19); moderate (n = 22); sparse (n = 14); and none (n = 12).
- In Study Two, the effectiveness of an electronic training program for Vizamyl image orientation and interpretation was evaluated using Vizamyl PET images from across subjects with different cognitive abilities who had participated in earlier studies. Inter-reader reproducibility of image interpretation was assessed using images from subjects with a truth standard (68 patients who underwent an autopsy and 36 known or suspected normal pressure hydrocephalus patients with in vivo brain biopsy) and without a truth standard (28 cognitively normal volunteers 55 years or above, 80 patients with amnestic mild cognitive impairment (aMCI), 33 patients with probable AD (pAD)), and 31 young healthy volunteers. Additionally, intra-reader reproducibility was assessed from 29 images (10%). Among the 276 subjects, the median age was 72 years (range 20 to 95), 136 were females, and 251 were Caucasian.
- Vizamyl performance characteristics for Study One and Study Two patients with an autopsy-based truth standard are shown in Table 6 and Table 7. Among patients who underwent autopsy (n=68; 43 positive and 25 negative based on histopathology), the median (and range) of correct read results, false negatives, and false positives were 59 (51, 61), 5 (3, 8), 3 (2, 14), respectively, for in-person training (Study One); and were 60 (55 to 61), 3 (3 to 6), 4 (2 to 10), respectively, for electronic media training (Study Two). Image reproducibility for various subject groups in Study Two is presented in Table 8. Inter-reader reproducibility analysis showed an overall Fleiss' kappa statistic of 0.83 (95% CI 0.79 to 0.86) which met the pre-specified success criterion (95% CI lower bound > 0.60). Intra-reader reproducibility analysis showed that, between the two readings for each of the 29 duplicate patient images, one of the five readers had complete agreement for all 29 images, two readers had discordant reads for a single image, and two readers had discordant reads for two images. Intra-reader reproducibility for a subgroup of 8 images from aMCI patients showed that all five readers had complete agreement for all duplicate images.

# How Supplied
- Vizamyl is supplied in a 10-mL or a 30-mL multi-dose glass vial with 1-10 mL and 1-30 mL fill volume respectively. Each vial is enclosed in an appropriate radiation shield. The total concentration is 150 MBq/mL (4.05 mCi/mL) of flutemetamol F 18 at reference date and time.

## Storage
- Store Vizamyl at 2 to 30C (36 to 86F). The product does not contain a preservative. Store Vizamyl within radiation shielding. Do not use Vizamyl after the expiry date and time stated on the label.
- Vizamyl must not be diluted. This preparation is for use by persons licensed by the Nuclear Regulatory Commission or the relevant regulatory authority of an Agreement State.

# Images

## Drug Images

## Package and Label Display Panel

### PRINCIPAL DISPLAY PANEL - SHIELD LABEL

### Ingredients and Appearance

# Patient Counseling Information
- Instruct patients to inform their healthcare provider if they:

# Precautions with Alcohol
- Alcohol-Flutemetamol F 18 interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

# Brand Names
- Vizamyl

# Look-Alike Drug Names
There is limited information regarding the look alike drug names.

# Drug Shortage Status

# Price