Oral microbiology

# Overview
Oral microbiology is the study of the microorganisms of the oral cavity and the interactions between the oral microorganisms with each other and with the host. Of particular interest is the role of oral microorganisms in the two major dental diseases: dental caries and periodontal disease.
The mouth harbors a diverse, abundant and complex microbial community. This highly diverse microflora inhabits the various surfaces of the  normal mouth. Bacteria accumulate on both the hard and soft oral tissues in biofilms. Bacterial adhesion is particularly important for oral bacteria.
Oral bacteria have evolved mechanisms to sense their environment and evade or modify the host. Bacteria occupy the ecological niche provided by both the tooth surface and gingival epithelium.  However, a highly efficient innate host defense system constantly monitors the bacterial colonization and prevents bacterial invasion of local tissues. A dynamic  equilibrium exists between dental plaque bacteria and the innate host defense system.

# Oral bacteria
Oral bacteria include streptococci, lactobacilli, staphylococci, corynebacteria, and various anaerobes in particular bacteroides. The oral cavity of the new-born baby does not contain bacteria but rapidly becomes colonized with bacteria such as Streptococcus salivarius. With the appearance of the teeth during the first year colonization by Streptococcus mutans and Streptococcus sanguis occurs as these organisms  colonise the dental surface and gingiva. Other strains of streptococci adhere strongly to the gums and cheeks but not to the teeth. The gingival crevice area (supporting structures of the teeth) provides a habitat for a variety of anaerobic species. Bacteroides and spirochetes colonize the mouth around puberty.

## Treponema denticola
The levels of oral spirochetes are elevated in patients with periodontal diseases. Among this group, Treponema denticola is the most studied and is considered as one of the main etiological bacteria of periodontitis. Treponema denticola is a motile and highly proteolytic bacterium.

## Porphyromonas gingivalis
Porphyromonas gingivalis is a Gram-negative oral anaerobe strongly associated with chronic adult periodontitis. The bacterium produces a number of well-characterized virulence factors and can be manipulated genetically. The availability of the genome sequence is aiding our understanding of the biology of P. gingivalis and how it interacts with the environment, other bacteria and the human host.

## Aggregatibacter actinomycetemcomitans
Aggregatibacter actinomycetemcomitans is considered an oral pathogen due to its virulence factors, its association with localized aggressive periodontitis in young adolescents, and studies indicating that it can cause bone loss.

# Dental plaque
Dental plaque is the material that adheres to the teeth and consists of bacterial cells (mainly S. mutans and S. sanguis), salivary polymers and bacterial extracellular products. Plaque is a  biofilm on the surfaces of the teeth. This accumulation of microorganisms subject the teeth and gingival tissues to high concentrations of bacterial metabolites which results in dental disease. If not taken care of, via brushing or flossing, the plaque can turn into tartar (its hardened form)and lead to gingivitis or periodontal disease.

# Cell-cell communication
Most of the bacterial species found in the mouth belong to microbial communities, called biofilms, a feature of which is inter-bacterial communication. Cell-cell contact, is mediated by specific protein adhesins and often, as in the case of inter-species aggregation, by complementary polysaccharide receptors. Another method of communication invoves cell-cell signalling molecules, which are of two classes: those used for intra-species and those used for inter-species signalling. An example of intra-species communication is quorum sensing. Oral bacteria have been shown to produce small peptides, such as competence stimulating peptides, which can help promote single-species biofilm formation. A common form of inter-species signalling is mediated by 4, 5-dihydroxy-2, 3-pentanedione (DPD) or Autoinducer-2 (Al-2).

# Vaccination against oral infections
Dental caries and periodontitis have an infectious etiology and immunization has been proposed as a means of controlling them. However, the approaches vary according to the nature of the bacteria involved and the mechanisms of pathogenesis for these two very different diseases. In the case of dental caries, proteins involved in colonization of teeth by Streptococcus mutans can produce antibodies that inhibit the cariogenic process. Periodontal vaccines are less well developed, but some antigenic targets have been identified.