Persius/hicric huggingface dataset:
HP1BP3
Heterochromatin protein 1, binding protein 3 is a protein that in humans is encoded by the HP1BP3 gene. It has been identified as a novel subtype of the linker histone H1, involved in the structure of heterochromatin 

# Model organisms
Model organisms have been used in the study of HP1BP3 function. A conditional knockout mouse line, called Hp1bp3tm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse Consortium program  a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists  at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty three tests were carried out and six significant phenotypes were reported. Fewer homozygous mutant embryos were identified during gestation than predicted by Mendelian ratio.  Homozygous mutant female adults had decreased body weight, heart weight and bone mineral density, and increased blood urea levels and T cell number.
HP1BP3 deficiency in mice results in severe dwarfism and impaired bone mass, caused by altered endocrine IGF-1 signaling. The gene is highly expressed in the brain and a number of behavioral phenotypes have been described for the mice. Lack of HP1BP3 led to impaired maternal behavior and reduced anxiety, leading to a dramatic reduction in litter survival. This may be related to the connection between HP1BP3 and postpartum depression in humans. Finally, HP1BP3 has been implicated in Alzheimer's disease..
HS1BP3
HCLS1 binding protein 3 also known as HS1BP3 is a protein which in humans is encoded by the HS1BP3 gene.

# Function
The protein encoded by this gene shares similarity with mouse Hs1bp3, an Hcls1-interacting protein that may be involved in lymphocyte activation.
HS1BP3 binds members of the 14-3-3 protein family, which are highly expressed in motor neurons and Purkinje cells and regulate the Ca2+ / calmodulin-dependent protein kinase activation of tyrosine and tryptophan hydroxylase.
HS3ST1
Heparan sulfate glucosamine 3-O-sulfotransferase 1 is an enzyme that in humans is encoded by the HS3ST1 gene.

# Function
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein.

# Clinical significance
Polymorphisms in HS3ST1 appear to be a risk factor for developing Alzheimer's disease.
HSPA1B
Heat shock 70kDa protein 1B, also known as HSPA1B, is a human gene. This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family.

# Function
In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.

# Disease linkage
Patients with chronic hepatitis B or hepatitis C virus infection who harbor a HSPA1B-1267 single nucleotide polymorphism have a higher risk for developing hepatocellular carcinoma.
HU-210

# Overview
HU-210 is a synthetic cannabinoid that was discovered around 1988 in the group of Dr Raphael Mechoulam at the Hebrew University. HU-210 is 100 to 800 times more potent than natural THC from cannabis and has an extended duration of action. HU-210 is the (+)-1,1-dimethylheptyl analog of 7-hydroxy-delta-6-tetrahydrocannabinol. The abbreviation HU stands for Hebrew University.
Per a 2005 article in the Journal Of Clinical Investigation, HU-210 with daily high doses over a few weeks stimulates neural growth in rats' hippocampus region, the opposite effect of drugs like alcohol, nicotine, heroin, and cocaine. It was also indicated by this increased neural growth to entail antianxiety and antidepressant effects.
HU-210, along side WIN 55,212-2 and JWH-133, is implicated in preventing the inflammation caused by Amyloid beta proteins involved in Alzheimer's Disease, in addition to preventing cognitive impairment and loss of neuronal markers. This anti-inflammatory action is induced through the agonization of cannabinoid receptors which prevents microglial activation that elicits the inflammation. Additionally, cannabinoids completely abolish neurotoxicity related to microglia activation in rat models.
HU-210 is a potent analgesic with many of the same effects as natural THC. This means that HU-210 could potentially be used in medicine as an alternative to medical marijuana, however its much stronger and longer lasting effects compared to those of THC could make appropriate titration of dosage difficult. Also because HU-210 is a CB1 full agonist as opposed to THC which is a partial agonist, the sedative effects of HU-210 are much more prominent, meaning that while fatal overdoses of THC itself are virtually impossible, they would be possible with HU-210.
Halide

# Overview
A halide is a binary compound, of which one part is a halogen atom  and the other part is an element or radical that is less electronegative than the halogen, to make a fluoride, chloride, bromide, iodide, or astatide compound.  Many salts are halides. All Group 1 metals form halides with the halogens and they are white solids.
A halide ion is a halogen atom bearing a negative charge.  The halide anions are fluoride (F), chloride (Cl), bromide (Br), iodide (I) and astatide (At).  Such ions are present in all ionic halide salts.

# Halides in organic chemistry
In organic chemistry halides represent a functional group. Any organic compound that contains a halogen atom can be considered a halide. Alkyl halides are organic compounds of the type R-X, containing an alkyl group R covalently bonded to a halogen X.
Pseudohalides resemble halides in their charge and reactivity; common examples are azides NNN-, isocyanate -NCO, Isocyanide, CN-, etc.
A chemical test for the detection of halogen in chemical substances is the Carius halogen method.

# Halides in lighting
Metal halides are used in high-intensity discharge lamps called metal halide lamps, such as those used in  modern street lights.  These are more energy-efficient than mercury-vapor lamps, and have much better colour rendition than orange high-pressure sodium lamps. Metal halide lamps are also commonly used in greenhouses or in rainy climates to supplement natural sunlight.
HID (High-intensity discharge) lamps however, contribute highly to light pollution. Sodium-vapor are favored for this reason.

# Halide compounds
Examples of halide compounds are:
- sodium chloride (NaCl)
- potassium chloride (KCl)
- potassium iodide (KI)
- lithium chloride (LiCl)
- copper(II) chloride (CuCl2)
- chlorine fluoride (ClF)
- Bromomethane (CH3Br)
- Iodoform (CHI3)
- silver chloride (AgCl)
Halite
Halite is the mineral form of sodium chloride, NaCl, commonly known as rock salt. Halite forms isometric crystals. The mineral is typically colourless to yellow, but may also be light blue, dark blue, and pink. It commonly occurs with  other evaporite deposit minerals such as several of the sulfates, halides and borates.

# Occurrence
Halite occurs in vast beds of sedimentary evaporite minerals that result from the drying up of enclosed lakes, playas, and seas. Salt beds may be up to 405 meters thick and underlie broad areas. In the United States and Canada extensive underground beds extend from the Appalachian basin of western New York through parts of Ontario and under much of the Michigan Basin. Other deposits are in Ohio, Kansas, New Mexico, Nova Scotia and Saskatchewan.
Salt domes are vertical diapirs or pipe-like masses of salt that have been essentially "squeezed up" from underlying salt beds by mobilization due to the weight of overlying rock. Salt domes contain anhydrite, gypsum, and native sulfur, in addition to halite and sylvite. They are common along the Gulf coasts of Texas and Louisiana and are often associated with petroleum deposits. Germany, Spain, the Netherlands, Romania and Iran also have salt domes. Salt glaciers exist in arid Iran where the salt has broken through the surface at high elevation and flows downhill.  In all of these cases, halite is said to be behaving in the manner of a rheid.
Unusual, purple, fibrous vein filling halite is found in France and a few other localities. Halite crystals termed hopper crystals appear to be "skeletons" of the typical cubes, with the edges present and stairstep depressions on, or rather in, each crystal face. In a rapidly crystallizing environment the edges of the cubes simply grow faster than the centers. Halite crystals form very quickly in some rapidly evaporating lakes resulting in modern artefacts with a coating or encrustation of halite crystals. Halite flowers are rare stalactites of curling fibers of halite that are found in certain arid caves of Australia's Nullarbor Plain. Halite stalactites and encrustations are also reported in the Quincy native copper mine of Hancock, Michigan.

# Uses
Halite is often used both residentially and municipally for managing ice. Because saline (a solution of water and salt) has a lower freezing point than ordinary water, putting salt on ice will cause it to melt. It is common for homeowners in cold climates to spread 'rock salt' on their walkways and sometimes driveways after a snow storm to melt the ice. It is not necessary to use so much salt that the ice is completely melted; rather, a small amount of salt will weaken the ice so that it can be easily removed with other means. Also, many cities will spread a mixture of sand and salt on roads during and after a snowstorm to improve traction.
Rock salt is also used to make ice cream. It is not actually used in the ice cream mixture; rather, it is used to melt the ice surrounding the can holding the ice cream, causing the ice to melt at a lower temperature, thus lowering the temperature of the ice bath and quickening the freezing process.
Harmal
Harmal (Peganum harmala) is a plant of the family Nitrariaceae, native from the eastern Mediterranean region east to India. It is also sometimes known as Syrian Rue, a confusing name as it is not related to rue (Ruta, family Rutaceae).
In the United States Peganum harmala grows as an invasive exotic in Arizona, California, Montana, New Mexico, Nevada, Oregon, Texas and Washington.

# Traditional uses
It has been used as an entheogen in the Middle East, and in modern Western culture, it is often used as an analogue of Banisteriopsis caapi to create an ad-hoc Ayahuasca, the notorious South American mixture of phyto-indoles including DMT with -carbolines. Syrian Rue however has distinct aspects from caapi and a unique entheogenic signature.
In Turkey dried capsules from this plant are strung and hung in homes or vehicles to protect against "the evil eye".
In Iran, dried capsules (known in Persian as  espnd or  esfnd-daneh) - mixed with other ingredients - are burnt so as to produce a light, distinctly scented smoke or incense. It is used as an air as well as mind purifier - perhaps linked to its entheogenic properties - and mostly as a charm against "the evil eye".   This Persian practice dates to pre-Islamic, Zoroastrian times.
Peganum harmala is also an abortifacient.

# Alkaloids
The active alkaloids of Harmal seeds are the MAOI (MonoAmine Oxidase Inhibitor) compounds harmine, harmaline, and tetrahydroharmine (collectively known as harmala alkaloids).  Harmaline is a "reversible inhibitor of MAO-A (RIMA)."  The seeds contain about 2-6% alkaloids, most of which is harmaline.
- Vasicine
- Vasicinone
Hazard
A Hazard is a situation which poses a level of threat to life, health, property or environment.  Most hazards are dormant or potential, with only a theoretical risk of harm, however, once a hazard becomes 'active', it can create an emergency situation.

# Modes of a Hazard
A hazard is usually used to describe a potentially harmful situation, although not usually the event itself - once the incident has started it is classified as an emergency or incident.  There are a number of modes for a hazard, which include:
- Dormant - The situation has the potential to be hazardous, but no people, property or environment is currently affected by this.  For instance, a hillside may be unstable, with the potential for a landslide, but there is nothing below or on the hillside which could be affected.
- Potential - Also known as 'Armed', this is a situation where the hazard is in the position to affect persons, property or environment.  This type of hazard is likely to require further risk assessment.
- Active - The hazard is certain to cause harm, as no intervention is possible before the incident occurs.
- Mitigated - A potential hazard has been identified, but actions have been taken in order to ensure it does not become an incident.  This may not be an absolute guarantee of no risk, but it is likely to have been undertaken to significantly reduce the danger.

# Classifying Hazards
By its nature, a hazard involves something which could potentially be harmful to a person's life, health, property or to the environment.  There are a number of methods of classifying a hazard, but most systems use some variation on the factors of Likelihood of the hazard turning into an incident and the Seriousness of the incident if it were to occur.
A common method is to score both likelihood and seriousness on a numerical scale (with the most likely and most serious scoring highest) and multiplying one by the other in order to reach a comparative score.
Risk = Likelihood of Occurrence x Seriousness if incident occurred.
This score can then be used to identify which hazards may need to be mitigated.  A low score on likelihood of occurrence may mean that the hazard is dormant, whereas a high score would indicate that it may be an Active hazard.

# Causes of hazards
There are many causes , but they can broadly be termed into:
- Natural - Natural hazards include anything which is caused by a natural process, and can include obvious hazards such as volcanoes to smaller scale hazards such as loose rocks on a hillside
- Man made - Hazards created by humans, which includes a huge array of possibilities, probably too many to list, as it includes long term (and sometimes disputed) effects such as global warming to immediate hazards such as building sites
- Activity related - Some hazards are created by the undertaking of a certain activity, and the cessation of the activity will negate the risk.  This includes hazards ie. flying.
de:Gefahrdung
el:
fi:Hasardi
Healia
Healia  is a health vertical search engine that uses algorithms to assess quality and to categorize documents. Healia, Inc. is located in Bellevue, Washington state, USA.

# Quality Index Score
Healia use patent-pending Quality Index ScoreTM to judge the quality of search results.

# Management team
President & Founder: Thomas R. Eng (VMD, MPH).
Thomas (Tom) Eng received a Small Business Innovation Research (SBIR) Award from the National Institutes of Health (NIH) in 2001 to develop this website. The National Cancer Institute (part of the NIH) assisted with research and development, and Healia was incorporated in March of 2005. It became available to the public in September of 2006. 
Healia was acquired by Meredith Corporation in June 2007.
Healia's CTO is Marcos Athanasoulis (MPH, DrPH) who runs the tech. 

# Drawbacks
The searching results are heavily US biased with many initial search results finding information from American web sites.
Heliox

# Overview
Heliox is a breathing gas that is composed of a mixture of helium (He) and oxygen (O2).
Heliox has been used in a medical context since the 1930s, and although the medical community adopted its use initially to alleviate the symptoms of upper airway obstruction, its range of medical uses has since expanded greatly, most of which are dependent on the low density of the gas.  Heliox is also used in saturation diving and sometimes during the deep phase of technical dives.

# Medical uses
In medicine, "heliox" generally describes a mixture that is 21% O2 (the same as air) and 79% He, although other mixtures are available.
Airway resistance is dictated by the diameter of the airways and by the density of the inspired gas.  Therefore when nitrogen (of air) is replaced by helium, airway resistance is reduced due to the lower density of the inspired gas.  This means that when one breathes Heliox, airway resistance is less, and therefore the mechanical energy required to ventilate the lungs, or the Work of Breathing (WOB) is decreased. Heliox is used mainly in the alleviation of many medical conditions that involve a decrease in airway diameter (and consequently increased airway resistance), such as upper airway obstruction, asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis and croup. Patients with these conditions may suffer a range of symptoms including dyspnea (breathlessness), hypoxemia (below-normal oxygen content in the arterial blood) and eventually a weakening of the respiratory muscles due to exhaustion, which can lead to respiratory failure and require intubation and mechanical ventilation - Heliox may reduce all these effects, making it easier for the patient to breathe, and as it will reduce work of breathing, Heliox can help to prevent this respiratory failure.  Heliox has also found utility in the weaning of patients off mechanical ventilation, and in the nebulization of inhalable drugs.
de:Heliox
nl:Heliox
sv:Heliox
Heroic

# Overview
In medicine, heroic refers to a treatment or course of therapy which possesses a high risk of causing further damage to a patient's health, but is undertaken as a last resort with the understanding that any lesser treatment will surely result in failure. 
Heroic measures are often taken in cases of grave injury or illness, as a last-ditch attempt to save life, limb, or eyesight. Examples include emergency trauma surgery conducted outside the operating room (such as "on-scene" surgical amputation, cricothyroidotomy, or thoracotomy), or administration of medication (such as certain antibiotics and chemotherapy drugs) at dosage levels high enough to potentially cause serious or fatal side effects.
Cardiopulmonary resuscitation is a particularly well-known heroic measure; vigorous chest compressions often result in fracturing one or more of the patient's ribs, but since the alternative is certain death, the technique is accepted as necessary.
Hexane
Hexane is an alkane hydrocarbon with the chemical formula CH3(CH2)4CH3. The "hex" prefix refers to its six carbons, while the "ane" ending indicates that its carbons are connected by single bonds. Hexane isomers are largely unreactive, and are frequently used as an inert solvent in organic reactions because they are very non-polar. They are also common constituents of gasoline and glues used for shoes, leather products and roofing.  Additionally, it is used in solvents to extract oils for cooking and as a cleansing agent for shoe, furniture and textile manufacturing.

# Isomers
Hexane has five isomers:
- Hexane, CH3CH2CH2CH2CH2CH3, a straight chain of six carbon atoms.
- 2-Methylpentane (Isohexane), CH3CH(CH3)CH2CH2CH3, a five-carbon chain with one methyl branch on the second.
- 3-Methylpentane, CH3CH2CH(CH3)CH2CH3, a five-carbon chain with one methyl branch on the third.
- 2,3-Dimethylbutane, CH3CH(CH3)CH(CH3)CH3, a four-carbon chain with one methyl branch on the second and third.
- 2,2-Dimethylbutane, CH3C(CH3)2CH2CH3, a four-carbon chain with two methyl branches on the second.

# Production
Hexane is produced by the refining of crude oil. The exact composition of the fraction depends largely on the source of the oil (crude or reformed) and the constraints of the refining. The industrial product (usually around 50% by weight of the straight-chain isomer) is the fraction boiling at 6570 C.

# Toxicity
The acute toxicity of hexane is relatively low, although it is a mild anesthetic. Inhalation of high concentrations produces first a state of mild euphoria, followed by somnolence with headaches and nausea.
Chronic intoxication from hexane has been observed in recreational solvent abusers and in workers in the shoe manufacturing, furniture restoration and automobile construction industries. The initial symptoms are tingling and cramps in the arms and legs, followed by general muscular weakness. In severe cases, atrophy of the skeletal muscles is observed, along with a loss of coordination and problems of vision.
Similar symptoms are observed in animal models. They are associated with a degeneration of the peripheral nervous system (and eventually the central nervous system), starting with the distal portions of the longer and wider nerve axons. The toxicity is not due to hexane itself but to one of its metabolites, hexane-2,5-dione. It is believed that this reacts with the amino group of the side chain of lysine residues in proteins, causing cross-linking and a loss of protein function.
The effects of hexane poisoning in humans are uncertain.  In 1994, n-hexane was included in the list of chemicals on the Toxic Release Inventory (TRI).  In the latter part of the 20th and early part of the 21st centuries, a number of explosions have been attributed to the combustion of hexane gas. 
In 2001, the U.S. Environmental Protection Agency issued regulations on the control of emissions of hexane gas due to its potential carcinogenic properties and environmental concerns.