Persius/hicric huggingface dataset:
Fibrillarin
rRNA 2'-O-methyltransferase fibrillarin is an enzyme that in humans is encoded by the FBL gene.

# Function
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing pre-ribosomal (r)RNA. It is associated with the U3, U8, and U13 small nucleolar RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.
Fibrillarin is a component of several ribonucleoproteins including a nucleolar small nuclear ribonucleoprotein (SnRNP) and one of the two classes of small nucleolar ribonucleoproteins (snoRNPs). SnRNAs function in RNA splicing while snoRNPs function in ribosomal RNA processing.
Fibrillarin is associated with U3, U8 and U13 small nuclear RNAs in mammals and is similar to the yeast NOP1 protein. Fibrillarin has a well conserved sequence of around 320 amino acids, and contains 3 domains, an N-terminal Gly/Arg-rich region; a central domain resembling other RNA-binding proteins and containing an RNP-2-like consensus sequence; and a C-terminal alpha-helical domain. An evolutionarily related pre-rRNA processing protein, which lacks the Gly/Arg-rich domain, has been found in various archaea.
A study by Schultz et al. indicated that the K-turn binding 15.5-kDa protein (called Snu13 in yeast) interacts with spliceosome proteins hPRP31, hPRP3, hPRP4, CYPH and the small nucleolar ribonucleoproteins NOP56, NOP58, and fibrillarin. The 15.5-kDa protein has sequence similarity to other RNA-binding proteins such as ribosomal proteins S12, L7a, and L30 and the snoRNP protein NHP2. The U4/U6 snRNP contains 15.5-kDa protein. The 15.5-kDa protein also exists in a ribonucleoprotein complex that binds the U3 box B/C motif. The 15.5-kDa protein also exists as one of the four core proteins of the C/D small nucleolar ribonucleoprotein that mediates methylation of pre-ribosomal RNAs.
Structural evidence supporting the idea that fibrillarin is the snoRNA methyltransferase has been reviewed.

# Interactions
Fibrillarin has been shown to interact with DDX5 and SMN1.
Fibrocystin
Fibrocystin is a large, receptor-like protein that is thought to be involved in the tubulogenesis and/or maintenance of duct-lumen architecture of epithelium.
FPC associates with the primary cilia of epithelial cells and co-localizes with the Pkd2 gene product polycystin-2 (PC2), suggesting that these two proteins may function in a common molecular pathway.

# Pathology
Mutations of its encoding gene (chromosomal locus 6p12.2) can cause autosomal recessive polycystic kidney disease.
Filoviridae
Filoviruses are viruses belonging to the family Filoviridae, which is in the order Mononegavirales. These viruses are single stranded negative sense RNA viruses that target primates.  There are two genera: the Ebola virus (Ebolavirus, with four species)  and the Marburg virus (Marburgvirus).
These viruses cause horrific viral hemorrhagic fevers, characterized by bleeding and coagulation abnormalities including diffuse bleeding.
The virions (viral particles) are characteristically shaped as long, cylindrical, filamentous particles which may be straight, curved, coiled, or found in a "6" or "U" shaped configuration.  They are occasionally branched and the particles vary greatly in length but the diameter (about 80nm) is consistent.
They are produced by budding from an infected cell, and consist of the viral RNA strand and proteins encapsulated in a lipid membrane formed from the host cell's plasma membrane.
The inability of the immune system to clear these viruses may, at least in part, be due to the complex synthesis of a viral glycoprotein which forms heterotrimeric spikes within the virions plasma membrane.  The gene encoding this protein in Ebola virus, but not Marburg virus, contains a stop codon and as a result two forms of the Ebola GP can be produced via a frame shift during translation.  The full length GP precursor then undergoes proteolytic cleavage to form GP while a truncated form of GP, secreted GP (sGP), is produced from the non-frame-shifted sequence.  This results in a variety of epitopes which may result in a less focused immune response that simply doesn't have the time to clear the infection before the organism succumbs.  
Another virally expressed protein recognised by the immune system is VP40 which is normally expressed on the membrane complexed to VP24.
The filoviridae family was discovered in 1967 when 31 people were infected with the Marburg virus in Marburg, Germany after working with tissue from monkeys imported from Uganda . Seven people who caught the disease died. All subsequent outbreaks have occurred in sub-Saharan Africa. The second genus of the filoviridae family, Ebola virus, was discovered in 1976 when outbreaks occurred in northern Zaire and southern Sudan. The Ebola virus is a very potent virus, having a mortality rate of 50% up to 90% reported in some of the Zaire outbreaks.
The natural reservoir of both the Marburg virus and the Ebola virus appears to be zoonotic, which means that the virus is transmitted to humans from other animals. Despite numerous attempts to find the source of both the Marburg and Ebola viruses, neither has been found. Bats though because they can replacate filoviriade-like viruses have been suspected .
The mechanisms through which filoviruses spread are not fully understood. The route of transmission from animals to humans is unknown. Person-to-person transmission occurs primarily through physical contact with infected bodily fluids.
Fingerprick
In medicine, some blood tests are conducted on venous blood obtained by fingerprick. There are various ways of opening a small wound that produces no more than a few drops of blood. The procedure can be painful, but may be quicker and less distressing than venipuncture.
After a droplet has formed, venous blood is sucked up by a capillary (a thin glass tube), usually passively or sometimes by indirect suction.
Tests commonly conducted on capillary blood are:
- glucose levels - diabetics often have a portable blood meter to check on their blood sugar.
- hemoglobin levels - fingerprick testing of hemoglobin is a quick screening procedure to check if a blood donor has a high enough blood count to be allowed to donate blood.
Fingerpricks are sometimes done on children and the elderly, when only a small amount of blood (less than 500 g) is needed for a test. Neonates (newborn babies) are given heelpricks instead, as this is less likely to cause permanent damage (and because babies have very small fingers).
Florfenicol

# Overview
Florfenicol (marketed by Schering-Plough Animal Health under the trade name Nuflor) is a fluorinated synthetic analog of thiamphenicol.
In the United States, florfenicol is currently indicated for the treatment of bovine respiratory disease (BRD) associated with Mannheimia (Pasteurella) haemolytica, Pasteurella multocida, and Haemophilus somnus, for treatment of bovine interdigital phlegmon (foot rot, acute interdigital necrobacillosis, infectious pododermatitis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus.
Florfenicol is also used in aquaculture, and is licensed for use in the United States for the control of enteric septicemia in catfish.
The use of florfenicol in horses, and likely in other equids, typically causes diarrhea.  This has been anecdotally reported to progress to lethal cases of acute colitis.  Therefore, use of this antimicrobial in the equine patient should be limited to cases in which other, safer, options are not available. 

# Contamination
Florfenicol was among the drug contaminants in a brand of supermarket eggs in Taiwan and Iran.
Flosequinan

# Overview
Flosequinan is a quinolone vasodilator.  It has direct relaxing effects on peripheral arteries and veins.  It is administered orally in cases of congestive heart failure in patients who are not responsive to digitalis or ACE inhibitors. It was sold under the trade name Manoplax.
It was withdrawn from the US market in October 1993 due to an increased risk of hospitalization or death.

# Synthesis
Both methods for forming the heterocyclic ring in quinolones involved cyclization into the carbocyclic ring. A closely related quinolone that displays cardiovascular rather than antibiotic activity is constructed by a condensation that closes the bond at the 2,3 position in the heterocyclic ring.
The starting material (2) is obtained by reaction of the aminoacetophenone derivative (1) with ethyl formate. Heating the product in ethylene glycol methyl ether leads to an aldol-like cyclization and the formation of a quinolone ring. The product, flosequinan (3), displays vasodilator and cardiotonic activities.
Fluid ounce
A fluid ounce (abbreviated fl oz, fl. oz. or oz. fl.) is a unit of volume in both the imperial and the US customary systems.  It is common to refer to the unit simply as an ounce, especially in cases where no confusion with the unit of mass is likely to occur.

# Definitions
Given the definitions above, we can calculate how many US fluid ounces are in one liter:
There are thus about 34 fluid ounces in one liter.

# References and notes
-  The imperial gallon was originally defined as the volume occupied by ten avoirdupois pounds at 62 F (16.7 C), weighed in air with brass weights.
-  Jump up to: 2.0 2.1 "The Units of Measurement Regulations 1995". 2000-09-20. Retrieved 2006-04-18..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"\"""\"""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{display:none;font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}
-  Jump up to: 3.0 3.1 One U.S. gallon is defined as 231 cubic inches.
-  Jump up to: 4.0 4.1 4.2 This assumes the international inch of exactly 25.4 millimetres.
-  "Food and Drug Administration, HHS" (PDF). Retrieved 2006-04-18.
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Flunarizine
Flunarizine is a drug classified as a calcium channel blocker. Flunarizine is a non-selective calcium entry blocker  with other actions including histamine H1 receptor blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy. It may help to reduce the severity and duration of attacks of paralysis associated with the more serious form of alternating hemiplegia, as well as being effective in rapid onset dystonia-parkinsonism (RDP).  Both these conditions share a mutation in the ATP13A gene; flunarizine is not available by prescription in the U.S. or Japan. Flunarizine has been shown to significantly reduce headache frequency and severity in both adults and children. Flunarizine was discovered at Janssen Pharmaceutica in 1968.

# Side effects and contraindications
Flunarizine has some side effects including weight gain, extrapyramidal effects, drowsiness and depression, it is contraindicated in hypotension, heart failure and arrhythmia.
Flunarizine use is avoided in patients with depression, severe constipation or those with extrapyramidal disorders.
Fluvalinate

# Overview
- Fluvalinate (trade names include Apistan, Klartan, Minadox) is a synthetic pyrethroid commonly used to control Diseases of the varroa mites in honey bee colonies.
- Fluvalinate is a stable, non-volatile, fat-soluble compound. Although the compound may be found in drones, a study has found honey samples virtually absent of fluvalinate, on account of its affinity to beeswax.
- Tau-fluvalinate (-fluvalinate) is the trivial name for (2R)-fluvalinate. The C atom in the valinate structure is in D-configuration, while the second chiral atom is a mixture of both R and S.
Home remedy

# Overview
A home remedy is a treatment to cure a disease or ailment that employs certain spices, vegetables, or other common items from the kitchen. Home remedies may or may not have actual medicinal properties that serve to treat or cure the disease or ailment in question, as they are typically passed along by laypersons (which has been facilitated in recent years by the Internet).; many are merely used as a result of tradition or habit or because they are quite effective in inducing the placebo effect. A significant number, however, have been demonstrated to effectively treat ailments such as sprains, minor lacerations, headaches, fevers, and even the common cold.
One of the more popular examples of a home remedy is the use of chicken soup to treat respiratory infections such as a cold or mild flu, and according to recent studies, this may actually be effective. Other examples of medically successful home remedies include: willow bark tea to cure headaches and fevers (willow bark contains a form of acetylsalicylic acid, also known as aspirin); duct tape to help with setting broken bones; and duct tape or superglue to treat plantar warts, and Kogel mogel to treat sore throat.
In earlier times mothers were entrusted with all but serious remedies.  Historic cookbooks are frequently full of remedies for dyspepsia, fevers and female complaints.   Many of the European liqueurs or digestifs were originally medicinal remedies.  In Chinese folk medicine, medicinal congees (long cooked rice soups with herbs), foods and soups are part of the healing repertoire.  
A common error is to confuse home remedies with homeopathic remedies. In fact, the two concepts are unrelated.
Forecasting
Forecasting is the process of estimation in unknown situations.  Prediction is a similar, but more general term, and usually refers to estimation of time series, cross-sectional or longitudinal data.  In more recent years, Forecasting has evolved into the practice of Demand Planning in every day business forecasting for manufacturing companies.  The discipline of demand planning, also sometimes referred to as supply chain forecasting, embraces both statistical forecasting and consensus process.
Forecasting is commonly used in discussion of time-series data.

# Categories of forecasting methods

## Time series methods
Time series methods use historical data as the basis for estimating future outcomes.
- Moving average
- Exponential smoothing
- Extrapolation
- Linear prediction
- Trend estimation
- Growth curve
- Topics

## Causal / econometric methods
Some forecasting methods use the assumption that it is possible to identify the underlying factors that might influence the variable that is being forecast.  For example, sales of umbrellas might be associated with weather conditions.  If the causes are understood, projections of the influencing variables can be made and used in the forecast.
- Regression analysis using linear regression or non-linear regression
- Autoregressive moving average (ARMA)
- Autoregressive integrated moving average (ARIMA)
- Econometrics

## Judgemental methods
Judgemental forecasting methods incorporate intuitive judgements, opinions and probability estimates.
- Composite forecasts
- Surveys
- Delphi method
- Scenario building
- Technology forecasting
- Forecast by analogy

## Other methods
- Simulation
- Prediction market
- Probabilistic forecasting and Ensemble forecasting

# Forecasting accuracy
The forecast error is the difference between the actual value and the forecast value for the corresponding period.
\ E_t = Y_t - F_t 
where E is the forecast error at period t, Y is the actual value at period t, and F is the forecast for period t.
Measures of aggregate error:
Please note that the business forecasters and demand planners in the industry refer to the PMAD as the MAPE, although they compute this volume weighted MAPE.  Difference between MAPE and WMAPE is explained in Calculating Demand Forecast Accuracy
See also
- Forecast error
- Calculating Demand Forecast Accuracy
- Predictability
- Prediction interval, similar to confidence interval

# Applications of forecasting
Forecasting has application in many situations:
- Supply chain management
- Weather forecasting and Meteorology
- Transport planning and Transportation forecasting
- Economic forecasting
- Technology forecasting
- Earthquake prediction
- Land use forecasting
- Product forecasting
- Player and team performance in sports
- Telecommunications forecasting
Statcoulomb
The statcoulomb (statC) or franklin (Fr) or electrostatic unit of charge (esu) is the physical unit for electrical charge used in the centimetre-gram-second (cgs) electrostatic system of units. The SI system of units uses the coulomb (C) instead. The conversion is
The conversion factor ( 3.33564Template:E) is equal to 10 divided by the numerical value of the speed of light, c, expressed in cm/s.
In the electrostatic cgs system, electrical charge is a fundamental quantity defined via the electrostatic force (see below); in the SI system, electrical current is fundamental and defined via the electromagnetic force while electrical charge is a derived quantity. The electrostatic system derives the electric charge from Coulomb's law and takes the permittivity as a dimensionless quantity whose value in a vacuum is 1/(4). Also the use of the permeability of vacuum,  \mu_0 \,\!, is avoided, having the consequence that the speed of light appears explicitly in some of the equations interrelating quantities in this system.
The statcoulomb is defined as follows: if two objects each carry a charge of 1 statC and are 1 cm apart, they will repel each other with a force of 1 dyne. As a result, in the electrostatic cgs system, Coulomb's law describing the force F between two charges q1 and q2 a distance r apart takes the simple form:
Note that in order for the Coulomb's law formula to work using the electrostatic cgs system, the dimension of electrical charge must be 1/2 3/2 -1. This is different from the dimension of coulombs which accounts for the fact that the factor k mentioned below is not dimensionless.
In SI units, the electrostatic constant k=\frac{1}{4\pi \epsilon_0} (where  \epsilon_0 \  is the permittivity of vacuum) has to be used. Several other laws of electromagnetism also become easier when all quantities are expressed in electrostatic cgs units; this is the main reason that the cgs system of units is still in use in physics and electrical engineering. The main drawback of this approach is that two other sets of cgs units and equations are defined, the electromagnetic and symmetrical systems (the latter system mixes the first two). The equations in all three systems are usually written in non-rationalized form, so-called because the factors 2 or 4 appear often in unexpected places (in situations not involving circular or spherical symmetry, respectively). It is possible, albeit less often done, to write each set of equations in rationalized form.
The coulomb is an extremely large charge rarely encountered in electrostatics, while the statcoulomb is closer to everyday charges.
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Fred Rosner
Fred Rosner M.D., FACP is Assistant Dean and professor of medicine at Albert Einstein College of Medicine, Professor of Medicine at Mount Sinai School of Medicine, and Director of the Department of Medicine at Queens Hospital Centre. Dr. Rosner is the Chairman of the Medical Ethics Committee of the state of New York.
Dr. Rosner has published almost 800 articles including 29 books and 39 chapters in books. These not only include all aspects of Jewish medical ethics and Jewish medical history, but also the multiple facets of haematology including leukemia and anaemia, immunology and general medicine. He has many publications including books on Maimonidies.
Dr. Rosner is an internationally known authority on medical ethics, having lectured widely on Jewish Medical Ethics throughout USA and has served as visiting professor or lecturer in Israel, England, France, Germany, Mexico, Canada, Holland, South Africa, New Zealand and Australia.
Fungus gnat
Fungus gnats are small, dark, short-lived flies, of the families Sciaridae and Mycetophilidae (order Diptera), whose larvae feed on plant roots or fungi and aid in the decomposition of organic matter. The adults are 2-5 mm long, and are important pollinators, and can also help spread mushroom spores.
They can be controlled by Hypoaspis miles or biological larvicide that kills the gnats in their larval stage. Detergents and the nicotine from tobacco brewed into a toxic tea are used by some people to control fungus gnats.
In houseplants the presence of fungus gnats may indicate overwatering. They may be feeding on roots that have sat in drain water too long and are rotting or may be attracted to fungus growing in saturated top soil. Typically draining the excess water from the plants drain pan and allowing the soil to dry will eliminate them. Fungus gnats are typically harmless to healthy plants, while their presence can be indicative of more serious problems.
GI Cocktail
In emergency medicine, a GI cocktail (gastrointestinal cocktail) is a generic term for a mixture of liquid antacid, viscous lidocaine, and an anticholinergic to treat dyspepsia.
A common type includes a mixtures of Maalox, Donnatal, and Xylocaine in equal parts. The theory is since these all work by different mechanisms, the mixture will be more effective than just one.
Many different combinations of GI cocktails are used, however, there is much dispute in recent research as to what is the best approach. Some researchers have found that many GI cocktails may not be as effective as one antacid.
GPX2 (gene)
Glutathione peroxidase 2 is an enzyme that in humans is encoded by the GPX2 gene.
This gene is a member of the glutathione peroxidase family encoding a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. Studies in knockout mice indicate that mRNA expression levels respond to luminal microflora, suggesting a role of the ileal glutathione peroxidases in preventing inflammation in the GI tract.
The antioxidant enzyme glutathione peroxidase 2 (Gpx2) is one out of eight known glutathione peroxidases (Gpx1-8) in humans. Mammalian Gpx1, GPx2 (this protein), Gpx3, and Gpx4 have been shown to be selenium-containing enzymes, whereas Gpx6 is a selenoprotein in humans with cysteine-containing homologues in rodents. In selenoproteins, the 21st amino acid selenocysteine is inserted in the nascent polypeptide chain during the process of translational recoding of the UGA stop codon.