Arenavirus

# Overview
The Arenaviridae are a family of viruses whose members are generally associated with rodent-transmitted diseases in humans. Each virus usually is associated with a particular rodent host species in which it is maintained. Arenavirus infections are relatively common in humans in some areas of the world and can cause severe illnesses.

## Arenaviridae
- Lassa virus belongs to Arenaviridae .
- The Arenaviridae are a family of viruses whose members are generally associated with rodent-transmitted diseases in humans. Each virus usually is associated with a particular rodent host species in which it is maintained. Arenavirus infections are relatively common in humans in some areas of the world and can cause severe illnesses.
- The virus particles are spherical and have an average diameter of 110-130 nanometers. All are enveloped in a lipid (fat) membrane. Viewed in cross-section, they show grainy particles that are ribosomes acquired from their host cells. It is this characteristic that gave them their name, derived from the Latin "arena", which means "sandy". Their genome, or genetic material, is composed of RNA only, and while their replication strategy is not completely understood, we know that new viral particles, called virions, are created by budding from the surface of their hosts' cells.

## History of Arenaviridae
- The first Arenavirus, Lymphocytic choriomeningitis virus (LCMV), was isolated in 1933 during a study of an epidemic of St. Louis encephalitis. Although not the cause of the outbreak, LCMV was found to be a cause of aseptic (nonbacterial) meningitis. By the 1960s, several similar viruses had been discovered and they were classified into the new family Arenaviridae. Since Tacaribe virus was found in 1956, new Arenavirus have been discovered on the average of every one to three years. A number of Arenavirus have been isolated in rodents only, but few cause hemorrhagic disease. Junin virus, isolated in 1958, was the first of these to be recognized. This virus causes Argentine hemorrhagic fever in a limited agrigultural area of the pampas in Argentina. Several years later, in 1963, in the remote savannas of the Beni province of Bolivia, Machupo virus was isolated. The next member of the virus family to be associated with an outbreak of human illness was Lassa virus in Nigeria in 1969. The most recent additions to these human pathogenic viruses were Guanarito detected in Venezuela in 1989, Sabia in Brazil in 1993, Chapare in Bolivia in 2004, and Lujo in South Africa in 2008.
Arenavirus is a genus of virus. The type species is Lymphocytic choriomeningitis virus (LCMV); it also includes the species responsible for Lassa fever.
Arena comes from the Latin root meaning sand.
Arenaviruses can be divided into two serogroups, which differ genetically and by geographical distribution:
- LCMV-Lassa virus (Old World) complex:
Ippy virus
Lassa virus
Lymphocytic choriomeningitis virus
Mobala virus
Mopeia virus
- Ippy virus
- Lassa virus
- Lymphocytic choriomeningitis virus
- Mobala virus
- Mopeia virus
- Tacaribe virus (New World) complex:
Amapari virus
Flexal virus
Guanarito virus
Junin virus
Latino virus
Machupo virus
Oliveros virus
Parana virus
Pichinde virus
Pirital virus
Sabia virus
Tacaribe virus
Tamiami virus
Whitewater Arroyo virus
- Amapari virus
- Flexal virus
- Guanarito virus
- Junin virus
- Latino virus
- Machupo virus
- Oliveros virus
- Parana virus
- Pichinde virus
- Pirital virus
- Sabia virus
- Tacaribe virus
- Tamiami virus
- Whitewater Arroyo virus
Some arenaviruses are zoonotic pathogens and are generally associated with rodent-transmitted disease in humans. Each virus usually is associated with a particular rodent host species in which it is maintained. The virus particles are spherical and have an average diameter of 110-130 nanometers. All are enveloped in a lipid membrane. Viewed in cross-section, they show grainy particles that are ribosomes acquired from their host cells. It is this characteristic that gave them their name, derived from the Latin "arena," which means "sandy." Their genome, or genetic material, is composed of RNA only, and while their replication strategy is not completely understood, we know that new viral particles, called virions, are created by budding from the surface of their hosts cells.