Topotecan (oral)

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# Black Box Warning

# Overview
Topotecan (oral) is a topoisomerase inhibitor that is FDA approved for the treatment of patients with relapsed small cell lung cancer. There is a Black Box Warning for this drug as shown here.  Common adverse reactions include neutropenia, anemia, and thrombocytopenia. The most common non-hematologic adverse reactions (all grades) were nausea,diarrhea, vomiting, alopecia, and fatigue.

# Adult Indications and Dosage

## FDA-Labeled Indications and Dosage (Adult)

## Indication
- Topotecan capsules are indicated for the treatment of relapsed small cell lung cancer in patients with a prior complete or partial response and who are at least 45 days from the end of first-line chemotherapy.

## Dosage

### Recommended Dosing
- The recommended dose of topotecan capsules is 2.3 mg/m2/day orally once daily for 5 consecutive days repeated every 21 days. Round the dose to the nearest 0.25 mg, and prescribe the minimum number of 1-mg and 0.25-mg capsules. Prescribe the same number of capsules for each of the 5 dosing days.
- Take topotecan capsules with or without food. Swallow capsules whole. Do not chew, crush, or divide the capsules. Do not prescribe a replacement dose for emesis.
Diarrhea:
- Do not administer topotecan capsules to patients with Grade 3 or 4 diarrhea. After recovery to Grade 1 or less, reduce the dose of topotecan by 0.4 mg/m2/day for subsequent courses.

### Dose Modification Guidelines
- Hematologic Toxicities:
- Do not administer subsequent courses of topotecan capsules until neutrophils recover to greater than 1,000 cells/mm3, platelets recover to greater than 100,000 cells/mm3, hemoglobin levels recover to greater than or equal to 9.0 g/dL (with transfusion if necessary).
- Dose reduce topotecan capsules by 0.4 mg/m2/day for:
- neutrophil counts of less than 500 cells/mm3 associated with fever or infection or lasting for 7 days or more;
- neutrophil counts of 500 to 1,000 cells/mm3 lasting beyond day 21 of the treatment course;
- platelet counts less than 25,000 cells/mm3.
- Renal Impairment:
- The recommended starting doses of topotecan capsules in patients with moderate and severe renal impairment are as follows:

### Dosage Forms and Strengths
- Topotecan capsules contain topotecan hydrochloride expressed as topotecan free base. The 0.25-mg capsules are opaque white to yellowish-white and imprinted with topotecan and 0.25 mg. The 1-mg capsules are opaque pink and imprinted with topotecan and 1 mg.

## Off-Label Use and Dosage (Adult)

### Guideline-Supported Use
- There is limited information regarding Off-Label Guideline-Supported Use of Topotecan (oral) in adult patients.

### NonGuideline-Supported Use
- There is limited information regarding Off-Label NonGuideline-Supported Use of Topotecan (oral) in adult patients.

# Pediatric Indications and Dosage

## FDA-Labeled Indications and Dosage (Pediatric)
- Safety and effectiveness in pediatric patients have not been established.

## Off-Label Use and Dosage (Pediatric)

### Guideline-Supported Use
- There is limited information regarding Off-Label Guideline-Supported Use of Topotecan (oral) in pediatric patients.

### NonGuideline-Supported Use
- There is limited information regarding Off-Label NonGuideline-Supported Use of Topotecan (oral) in pediatric patients.

# Contraindications
- Topotecan is contraindicated in patients who have a history of severe hypersensitivity reactions to topotecan.

# Warnings

## Bone Marrow Suppression
- Bone marrow suppression (primarily neutropenia) is a dose-limiting toxicity of topotecan. Neutropenia is not cumulative over time. The following data on myelosuppression are based on an integrated safety database from 4 thoracic malignancy trials (N = 682) using topotecan capsules at 2.3 mg/m2/day for 5 consecutive days. The median day for neutrophil and platelet nadirs occurred on Day 15.

### Neutropenia:
- Grade 4 neutropenia (<500 cells/mm3) occurred in 32% of patients with a median duration of 7 days and was most common during Course 1 of treatment (20% of patients). Clinical sequelae of neutropenia included infection (17%), febrile neutropenia (4%), sepsis (2%), and septic death (1%). Pancytopenia has been reported.
- Topotecan can cause fatal typhlitis (neutropenic enterocolitis). Consider the possibility of typhlitis in patients presenting with fever, neutropenia, and abdominal pain.

### Thrombocytopenia:
- Grade 4 thrombocytopenia (<10,000 cells/mm3) occurred in 6% of patients, with a median duration of 3 days.

### Anemia:
- Grade 3 or 4 anemia (<8 g/dL) occurred in 25% of patients.
- Administer the first course of topotecan only to patients with a neutrophil count of 1,500 cells/mm3 and a platelet count 100,000 cells/mm3. Monitor peripheral blood cell counts frequently during treatment with topotecan. Refer to Section 2.2 for dose modification guidelines for hematological toxicities in subsequent courses.

## Diarrhea
- Diarrhea, including severe and life-threatening diarrhea requiring hospitalization, can occur during treatment with topotecan capsules. Diarrhea caused by topotecan capsules can occur at the same time as drug-induced neutropenia and its sequelae. In the 682 patients who received topotecan capsules in the 4 lung cancer trials, the incidence of diarrhea caused by topotecan capsules was 22%, with 4% Grade 3 and 0.4% Grade 4.The incidence of Grade 3 or 4 diarrhea proximate (within 5 days) to Grade 3 or 4 neutropenia events in the group receiving topotecan capsules was 5%. The median time to onset of Grade 2 or worse diarrhea was 9 days in the group receiving topotecan capsules. Manage diarrhea caused by topotecan capsules aggressively. Do not administer topotecan capsules to patients with Grade 3 or 4 diarrhea. Reduce the dose of topotecan after recovery to Grade 1 or less.

## Interstitial Lung Disease
- Interstitial lung disease (ILD), including fatalities, has occurred with topotecan. Underlying risk factors include history of ILD, pulmonary fibrosis, lung cancer, thoracic radiation, and use of pneumotoxic drugs and/or colony stimulating factors. Monitor patients for pulmonary symptoms indicative of interstitial lung disease (e.g., cough, fever, dyspnea, and/or hypoxia), and discontinue topotecan if a new diagnosis of ILD is confirmed.

## Embryofetal Toxicity
- Topotecan can cause fetal harm when administered to a pregnant woman. Topotecan caused embryolethality, fetotoxicity, and teratogenicity in rats and rabbits when administered during organogenesis. If this drug is used during pregnancy, or if a patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to a fetus.
- Advise females of reproductive potential to use highly effective contraception during treatment and for at least 1 month after the last dose of topotecan. Advise patients to contact their healthcare provider if they become pregnant, or if pregnancy is suspected, while taking topotecan.

# Adverse Reactions

## Clinical Trials Experience
- Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.
The safety of topotecan capsules was evaluated in 682 patients with lung cancer (3 recurrent small cell lung cancer  trials and 1 recurrent non-small cell lung cancer  trial) who received at least one dose of topotecan capsules. Patients in all four trials had advanced lung malignancies and received prior chemotherapy in the first-line setting. The dose regimen for topotecan capsules was 2.3 mg/m2/day for five consecutive days every 21 days. The median number of courses was 3 (range: 1 to 20) in these four trials. Table 2 describes the hematologic and non-hematologic adverse reactions in recurrent SCLC patients treated with topotecan capsules in the overall lung cancer patient population.
On-Study Death Due to Toxicity of topotecan:
- In the 682 patients who received topotecan capsules in the four lung cancer trials, 39 deaths (6%) occurred within 30 days after the last dose for a reason other than progressive disease: 13 due to hematologic toxicity, 5 due to non-hematologic toxicity (2 from diarrhea), and 21 due to other causes.

## Postmarketing Experience
- There is limited information regarding postmarketing experience.

# Drug Interactions
- Topotecan is a substrate for both P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP). Inhibitors of these transporters increase the systemic exposure to oral topotecan. Avoid concomitant use of P-gp inhibitors (e.g., amiodarone, azithromycin, captopril, carvedilol, clarithromycin, conivaptan, cyclosporine, diltiazem, dronedarone, erythromycin, felodipine, itraconazole, ketoconazole, lopinavir, ritonavir, quercetin, quinidine, ranolazine, ticagrelor, verapamil) and BCRP inhibitors (e.g., cyclosporine, eltrombopag) with topotecan capsules.

# Use in Specific Populations

### Pregnancy
Pregnancy Category (FDA): D
Risk Summary:
- Topotecan can cause fetal harm when administered to a pregnant woman. Topotecan caused embryolethality, fetotoxicity, and teratogenicity in rats and rabbits when administered during organogenesis. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, inform the patient of the potential hazard to a fetus.
Animal Data:
- In rabbits, an IV dose of 0.10 mg/kg/day (about equal to the clinical IV dose on a mg/m2 basis) given on days 6 through 20 of gestation caused maternal toxicity, embryolethality, and reduced fetal body weight. In the rat, an IV dose of 0.23 mg/kg/day (about equal to the clinical IV dose on a mg/m2 basis) given for 14 days before mating through gestation day 6 caused fetal resorption, microphthalmia, pre-implant loss, and mild maternal toxicity. Administration of an IV dose of 0.10 mg/kg/day (about half the clinical IV dose on a mg/m2 basis) to rats on days 6 through 17 of gestation caused an increase in post-implantation mortality. This dose also caused an increase in total fetal malformations. The most frequent malformations were of the eye (microphthalmia, anophthalmia, rosette formation of the retina, coloboma of the retina, ectopic orbit), brain (dilated lateral and third ventricles), skull, and vertebrae.
Pregnancy Category (AUS): 
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Topotecan (oral) in women who are pregnant.

### Labor and Delivery
There is no FDA guidance on use of Topotecan (oral) during labor and delivery.

### Nursing Mothers
- It is not known whether topotecan is present in human milk. Lactating rats excrete high concentrations of topotecan into milk. Female rats given 4.72 mg/m2 IV (about twice the clinical dose on a mg/m2 basis) excreted topotecan into milk at concentrations up to 48-fold higher than those in plasma. Because many drugs are present in human milk, and because of the potential for serious adverse reactions in nursing infants from topotecan, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

### Pediatric Use
- Safety and effectiveness in pediatric patients have not been established.

### Geriatic Use
- Of the 682 patients with thoracic cancer in 4 clinical trials who received topotecan capsules, 33% (n = 225) were aged 65 years and older, while 4.8% (n = 33) were aged 75 years and older. Treatment-related diarrhea was more frequent in patients aged 65 years (28%) compared with those younger than 65 years (19%).
- No overall differences in effectiveness were observed between patients 65 years and older and younger patients.

### Gender
There is no FDA guidance on the use of Topotecan (oral) with respect to specific gender populations.

### Race
There is no FDA guidance on the use of Topotecan (oral) with respect to specific racial populations.

### Renal Impairment
- The systemic exposure to both topotecan lactone and total topotecan increased in patients with renal impairment compared with that in patients with normal renal function. No dosage adjustment is recommended for patients with mild renal impairment (CLcr = 50-79 mL/min). Adjust the dose of topotecan capsules in patients with moderate (CLcr = 30-49 mL/min) and severe (CLcr <30 mL/min) renal impairment.

### Hepatic Impairment
There is no FDA guidance on the use of Topotecan (oral) in patients with hepatic impairment.

### Females of Reproductive Potential and Males
Contraception:
- Females: Counsel patients on pregnancy planning and prevention. Advise female patients of reproductive potential to use highly effective contraception during and for 1 month following treatment with topotecan. Advise patients to contact their healthcare provider if they become pregnant, or if pregnancy is suspected, while taking topotecan.
- Males: topotecan may damage spermatozoa, resulting in possible genetic and fetal abnormalities. Advise males with a female sexual partner of reproductive potential to use effective contraception during and for 3 months after treatment with topotecan.
Infertility:
- Females: In females of reproductive potential, topotecan may have both acute and long-term effects on fertility.
- Males: Effects on spermatogenesis have been observed in animals administered topotecan. Advise males of the potential risk for impaired fertility and to seek counseling on fertility and family planning options prior to starting treatment.

### Immunocompromised Patients
There is no FDA guidance one the use of Topotecan (oral) in patients who are immunocompromised.

# Administration and Monitoring

### Administration
- Oral.

### Monitoring
- Monitor peripheral blood cell counts frequently during treatment with topotecan.
- Monitor patients for pulmonary symptoms indicative of interstitial lung disease.
- Monitor the patient closely for bone marrow suppression.

# IV Compatibility
- There is limited information regarding IV Compatibility.

# Overdosage
- Overdoses (up to 5-fold of the prescribed dose) occurred in patients treated with topotecan capsules. The primary complication of overdosage is bone marrow suppression. The observed signs and symptoms of overdose are consistent with the known adverse reactions associated with topotecan for oral use. Mucositis has also been reported in association with overdose.
- There is no known antidote for overdosage with topotecan. If an overdose is suspected, monitor the patient closely for bone marrow suppression, and institute supportive-care measures (such as the prophylactic use of G-CSF and/or antibiotic therapy) as appropriate.

# Pharmacology

## Mechanism of Action
- Topoisomerase I relieves torsional strain in DNA by inducing reversible single-strand breaks. Topotecan binds to the topoisomerase I-DNA complex and prevents re-ligation of these single strand breaks. The cytotoxicity of topotecan is thought to be due to double-strand DNA damage produced during DNA synthesis, when replication enzymes interact with the ternary complex formed by topotecan, topoisomerase I, and DNA. Mammalian cells cannot efficiently repair these double-strand breaks.

## Structure
- Topotecan hydrochloride is a semi-synthetic derivative of camptothecin and is an anti-tumor drug with topoisomerase I-inhibitory activity.
- The chemical name for topotecan hydrochloride is (S)-10--4-ethyl-4,9-dihydroxy-1H-pyrano indolizino quinoline-3,14-(4H,12H)-dione monohydrochloride. It has the molecular formula C23H23N3O5HCl and a molecular weight of 457.9. It is soluble in water and melts with decomposition at 213 to 218C.
- Topotecan hydrochloride has the following structural formula:
- Topotecan capsules for oral use contain topotecan hydrochloride, the content of which is expressed as topotecan free base. The excipients are gelatin, glyceryl monostearate, hydrogenated vegetable oil, and titanium dioxide. The capsules are imprinted with edible black ink. The 1-mg capsules also contain red iron oxide.

## Pharmacodynamics
- There is limited information regarding pharmacodynamics.

## Pharmacokinetics
- Following administration of topotecan capsules at doses of 1.2 to 3.1 mg/m2 administered daily for 5 days in cancer patients, topotecan exhibited biexponential pharmacokinetics with a mean terminal half-life of 3 to 6 hours. Total exposure (AUC) increased approximately proportionally to dose.

### Absorption:
- Topotecan is rapidly absorbed with peak plasma concentrations occurring between 1 to 2 hours following oral administration. The oral bioavailability of topotecan is approximately 40%. Following a high-fat meal, the extent of exposure was similar in the fed and fasted states, while Tmax was delayed from 1.5 to 3 hours for topotecan lactone and from 3 to 4 hours for total topotecan. Topotecan capsules can be given without regard to food.

### Distribution:
- Binding of topotecan to plasma proteins is approximately 35%.

### Metabolism:
- Topotecan undergoes a reversible pH-dependent hydrolysis of its lactone moiety; it is the lactone form that is pharmacologically active. At pH 4, the lactone is exclusively present, whereas the ring-opened hydroxy-acid form predominates at physiologic pH. The mean metabolite:parent AUC ratio was <10% for total topotecan and topotecan lactone.

### Excretion:
- In a mass balance study in 4 patients with advanced solid tumors, the overall recovery of drug-related material following 5 daily doses of topotecan was 57% of the administered oral dose. In the urine, 20% of the orally administered dose was excreted as total topotecan and 2% was excreted as N-desmethyl topotecan.
- Fecal elimination of total topotecan accounted for 33%, while fecal elimination of N-desmethyl topotecan was 1.5%. Overall, the N-desmethyl metabolite contributed a mean of <6% (range: 4% to 8%) of the total drug-related material accounted for in the urine and feces. O-glucuronides of both topotecan and N-desmethyl topotecan have been identified in the urine.

### Specific Populations:
- Age and Gender: A cross-study analysis in 217 patients with advanced solid tumors indicated that age and gender did not significantly affect the pharmacokinetics of oral topotecan.
- Race: In patients with normal renal function, the exposures (geometric mean dose-normalized AUCinf) to topotecan lactone and total topotecan each were approximately 30% higher in Asian patients (n = 7) compared with Caucasian patients (n = 11).
- In patients with mild renal impairment, the exposure was 30% higher for topotecan lactone in Asian (n = 7) compared with Caucasian (n = 12) patients, but the exposure to total topotecan was similar.
- In patients with moderate renal impairment, the exposure was 60% higher for both topotecan lactone and total topotecan in Asian (n = 8) compared with Caucasian patients (n = 6).
- In patients with severe renal impairment, the exposure was 112% higher for topotecan lactone and 70% higher for total topotecan in Asian (n = 3) compared with Caucasian patients (n = 4).
- Renal Impairment: A trial was conducted in 59 patients with advanced cancer who were grouped based on the degree of their renal function and received topotecan capsules as shown in the table below.
- The exposure (geometric mean dose-normalized AUCinf) for topotecan lactone increased by 34%, 80%, and 114% in Caucasian patients with mild, moderate, and severe renal impairment, respectively, compared with that in Caucasian patients with normal renal function. The corresponding values for total topotecan in Caucasian patients were 70%, 108%, and 227%, respectively. Asian patients with mild, moderate, and severe renal impairment had a 34%, 121%, and 247% higher exposure to topotecan lactone, respectively, than Asian patients with normal renal function. The corresponding values for total topotecan in Asian patients are 26%, 153%, and 331%, respectively. Prior platinum-based chemotherapy (P-B CT) had no effect on the systemic exposure to both total topotecan and topotecan lactone in patients with normal renal function.
- No dosage adjustment is recommended for patients with mild renal impairment. Adjust the dosage of topotecan capsules in patients with moderate and severe renal impairment.
- Hepatic Impairment: In a population pharmacokinetic analysis involving oral topotecan administered at doses of 0.15 to 2.7 mg/m2/day to 118 cancer patients, the pharmacokinetics of total topotecan did not differ significantly based on patient serum bilirubin, ALT, or AST.

### Drug Interactions:
- Effects of Topotecan on Drug-Metabolizing Enzymes: In vitro inhibition studies using marker substrates known to be metabolized by human cytochromes P450 (CYP1A2, CYP2A6, CYP2C8/9, CYP2C19, CYP2D6, CYP2E, CYP3A, or CYP4A) or dihydropyrimidine dehydrogenase indicate that the activities of these enzymes were not altered by topotecan. Enzyme inhibition by topotecan has not been evaluated in vivo.
- Drugs That Inhibit Drug Efflux Transporters: Following coadministration of escalating doses of a dual inhibitor of BCRP and P-gp with oral topotecan, the AUCinf of topotecan lactone and total topotecan increased approximately 2.5-fold compared with control.
- Administration of oral cyclosporine A (15 mg/kg), an inhibitor of P-gp, multidrug-resistance-associated protein (MRP-1), and cytochrome P450 3A4 (CYP3A4) within 4 hours of oral topotecan increased the dose-normalized AUC0-24h of topotecan lactone and total topotecan 2.0- to 3.0-fold compared with control.
- Effect of pH-Elevating Agents: The pharmacokinetics of oral topotecan were unchanged when coadministered with ranitidine.

## Nonclinical Toxicology

### Carcinogenesis, Mutagenesis, Impairment of Fertility
- Carcinogenicity testing of topotecan has not been done. Nevertheless, topotecan is known to be genotoxic to mammalian cells and is a probable carcinogen. Topotecan was mutagenic to L5178Y mouse lymphoma cells and clastogenic to cultured human lymphocytes with and without metabolic activation. It was also clastogenic to mouse bone marrow. Topotecan did not cause mutations in bacterial cells.
- Topotecan given to female rats prior to mating at a dose of 1.4 mg/m2 IV (about 0.6 times the oral clinical dose on a mg/m2 basis) caused superovulation possibly related to inhibition of follicular atresia. This dose given to pregnant female rats also caused increased pre-implantation loss. Studies in dogs given 0.4 mg/m2 IV (about 0.2 times the oral clinical dose on a mg/m2 basis) of topotecan daily for a month suggest that treatment may cause an increase in the incidence of multinucleated spermatogonial giant cells in the testes. Topotecan may impair fertility in women and men.

# Clinical Studies

### Small Cell Lung Cancer
- The efficacy of topotecan capsules was studied in 141 patients with relapsed SCLC in a randomized, controlled, open-label trial. The patients were prior responders (complete or partial) to first-line chemotherapy, were not considered candidates for standard intravenous chemotherapy, and had relapsed at least 45 days from the end of first-line chemotherapy. Seventy-one patients were randomized to topotecan capsules (2.3 mg/m2/day administered for 5 consecutive days repeated every 21 days) and Best Supportive Care (BSC) and 70 patients were randomized to BSC alone. The primary objective was to compare the overall survival between the treatment arms. Patients in the arm receiving topotecan capsules plus BSC received a median of 4 courses (range: 1 to 10) and maintained a median dose intensity of 3.77 mg/m2/week. The median patient age in the arm receiving topotecan capsules plus BSC and the BSC-alone treatment arm was 60 years and 58 years while the percentage of patients aged >65 years was 34% and 29%, respectively. The majority of patients were Caucasian (99.3%) and male (73%). Eighty percent of patients receiving topotecan capsules plus BSC previously received carboplatin or cisplatin, and 77% of patients in the BSC-alone arm received prior carboplatin or cisplatin. The arm receiving topotecan capsules plus BSC included 68% of patients with extensive disease and 28% with liver metastasis. In the BSC- alone arm, 61% of patients had extensive disease and 20% had liver metastases. Both treatment arms recruited 73% males. In the arm receiving topotecan capsules plus BSC, 18% of patients had prior carboplatin and 62% had prior cisplatin. In the BSC-alone arm, 26% of patients had prior carboplatin and 51% had prior cisplatin.
- The arm receiving topotecan capsules plus BSC showed a statistically significant improvement in overall survival compared with the BSC-alone arm (Log-rank P = 0.0104). Survival results are shown in Table 3 and Figure 1.

# How Supplied
- The 0.25-mg topotecan capsules are opaque white to yellowish-white imprinted with topotecan and 0.25 mg and are available in bottles of 10: NDC 0007-4205-11.
- The 1-mg topotecan capsules are opaque pink imprinted with topotecan and 1 mg and are available in bottles of 10: NDC 0007-4207-11.

## Storage
- Store refrigerated 2C to 8C (36F to 46F). Store the bottles protected from light in the original outer cartons.
- Topotecan is a cytotoxic drug. Follow applicable special handling and disposable procedures.

# Images

## Drug Images

## Package and Label Display Panel

# Patient Counseling Information
- Advise the patient to read the FDA-approved patient labeling (Patient Information)
- Bone Marrow Suppression
- Inform patients that HYCAMTIN decreases blood cell counts such as white blood cells, platelets, and red blood cells. Instruct patients to notify their healthcare provider promptly for fever or other signs of infection such as chills, cough, or burning pain on urination. Advise patients that frequent blood tests will be performed while taking HYCAMTIN to monitor for bone marrow suppression.
- Embryofetal Toxicity
- Advise patients on pregnancy planning and prevention. Advise females of reproductive potential to use highly effective contraception during treatment and for 1 month following treatment with HYCAMTIN.
- Advise males with a female sexual partner of reproductive potential to use effective contraception during and for 3 months after treatment.
- Nursing Mothers
- Advise patients to discontinue nursing during treatment with HYCAMTIN.
- Infertility
- Advise male and female patients of the potential risk for impaired fertility and possible family planning options.
- Diarrhea
- Inform patients that HYCAMTIN capsules cause diarrhea which may be severe and life-threatening. Instruct patients how to manage and/or prevent diarrhea and to inform their physician if severe diarrhea occurs during treatment with HYCAMTIN capsules.

# Precautions with Alcohol
- Alcohol-Topotecan (oral) interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

# Brand Names
- HYCAMTIN 

# Look-Alike Drug Names
- There is limited information regarding Look-Alike Drug Names.

# Drug Shortage Status

# Price