Sinclair Method
The Sinclair Method is a treatment for alcoholism that involves the use of opiate antagonists such as naltrexone or nalmefene in order to decrease the craving for alcohol over time, while the person continues to consume alcohol.  It relies upon a mechanism called pharmacological extinction, where involuntary impulses are reduced through the introduction of a stimulus without the subsequent reward.

# History and Theory
In the 1970s, Finland's National Public Health Institute developed a breed of Wistar rats called the AA line which were more prone to alcoholism.   The research facility determined that this tendency was caused by an increased reactivity of their endorphin system to the consumption of alcohol.  Both human and rat biology reacts to the presence of alcohol by releasing endorphins, and these rats produced more endorphins in that event than a typical rat.
Endorphins are part of the body's reward system for performing healthy behaviors. Sex, exercise, eating, and risk taking generally result in the release of endorphins.  The endorphins "teach" the body that the behaviors that were performed prior to the endorphin release are behaviors that should be repeated.  The link between the more active endorphin system and alcoholism in rats suggests that the release of endorphins by alcohol teaches the body to believe that drinking alcohol is an activity that should be repeated.
Classical conditioning suggests that, should you perform a behavior and be rewarded, then the urge to perform that behavior becomes stronger.  Furthermore, if you perform a behavior and are not rewarded, then the urge to perform that behavior gets weaker.  This effect is referred to as the extinction of that behavior.
Based on the Pavlovian classical conditioning, the addict must perform the behaviors that they are attempting to extinguish and not be rewarded by the endorphins. Tests with the AA rats confirmed that this effect involved not only the actual consumption of alcohol, but also the sensory stimulus that the creature experienced while consuming alcohol.

# Treatment
Dr. John David Sinclair used these results to develop a treatment for alcoholism for humans.  For it to work, the patients need to take a drug which prevented endorphins from rewarding them for drinking.  Naltrexone was originally used, although other drugs are now available for this purpose.  The patients also needed to expose themselves to the conditions under which they developed their addiction.  This means not just drinking alcohol, but consuming it in the same environment in which they developed their addiction.
This resulted in an extremely simple treatment for alcoholics.  A daily dose of naltrexone effectively blocked endorphins.  Beyond that, it was just a matter of the alcoholics going about their life as usual.  They drank when they had the urge, and the urge was extinguished over roughly a three month period.  Periodic psychological counselling improved the speed and effectiveness of the treatment considerably, although the frequency of this counselling varies more based on the budget of those paying for it than on the level of effectiveness.

# Obstacles
This treatment was approved by the FDA for use in the US in 1994.  Since then, its adoption has been slow and spotty.  Dissemination of information of the treatment has been blocked by all of the existing treatment organizations.
Project Combine, the largest controlled clinical trial in the alcoholism treatment field, published in the Journal of the American Medical Association in May, 2006, has shown "that while naltrexone was effective in its own right, combining it with the specialized counseling added no more effectiveness than naltrexone by itself" according to Dr. Raymond Anton, the coordinator for the trial.  Naltrexone had been approved by the FDA for use within a comprehensive program of alcoholism treatment. The new results should lift this requirement, allowing doctors to prescribe naltrexone with only medical supervision but without intensive therapy.  This confirms findings from earlier smaller trials with naltrexone in Australia and with nalmefene in Finland. Of course, other forms of counseling may still add benefits, but the pills do work alone.
The medical community has been largely unconvinced of the effectiveness of this cure.

# Notes
-  KTL (National Public Health Institute, Finland) - Research