Chromosome 10
Chromosome 10 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 10 spans about 133 million base pairs (the building material of DNA) and represents between 4 and 4.5 percent of the total DNA in cells.

# Genes

## Number of genes
The following are some of the gene count estimates of human chromosome 10. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project (CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.

## Gene list
The following is a partial list of genes on human chromosome 10. For complete list, see the link in the infobox on the right.
- AFAP1L2: actin filament associated protein 1 like 2
- ALL1 encoding protein Leukemia, acute lymphocytic, susceptibility to, 1
- ALOX5: Arachidonate 5-Lipoxygenase (processes essential fatty acids to leukotrienes, which are important agents in the inflammatory response; also facilitates development and maintenance of cancer stem cells, slow-dividing cells thought to give rise to a variety of cancers, including leukemia)
- ARHGAP21: rho GTPase activating protein 21
- ARID5B: encoding protein AT-rich interactive domain-containing protein 5B
- AS3MT: encoding enzyme Arsenite methyltransferase
- AVPI1: encoding protein Arginine vasopressin-induced protein 1
- C10orf118: encoding protein Uncharacterized protein C10orf118
- C10orf67: chromosome 10 open reading frame 67
- C10orf76: chromosome 10 open reading frame 76
- C10orf99: encoding protein Chromosome 10 open reading frame 99
- CAMK1D: calcium/calmodulin-dependent protein kinase ID
- CCAR1: Cell division cycle and apoptosis regulator 1
- CCDC3: Coiled-coil domain-containing protein 3
- CCNY: Cyclin-Y
- CDC123: Cell division cycle protein 123 homolog
- CDH23: cadherin-like 23
- CDNF: cerebral dopamine neurotrophic factor
- COMMD3-BMI1: COMMD3-BMI1 readthrough
- CUTC: Copper homeostasis protein cutC homolog
- CXCL12: chemokine (C-X-C motif) ligand 12, SDF-1, scyb12
- DDX50: DExD-box helicase 50
- DEPP: decidual protein induced by progesterone
- DHX32: DEAH-box helicase 32
- DNAJC12: DnaJ (Hsp40) homolog, subfamily c, member 12
- DNAJC9: DnaJ (Hsp40) homolog, subfamily c, member 9
- DPYSL4: Dihydropyrimidinase-related protein 4
- EBLN1: encoding protein Endogenous Bornavirus-like nucleoprotein 1
- ECD: ecdysoneless cell cycle regulator
- EGR2: early growth response 2 (Krox-20 homolog, Drosophila)
- EIF5AP1: eukaryotic translation initiation factor 5A-like 1
- EPC1: Enhancer of polycomb homolog 1
- ERCC6: excision repair cross-complementing rodent repair deficiency, complementation group 6
- FAM107B: family with sequence similarity 107, member B
- FAM13C: family with sequence similarity 13, member C
- FAM170B: encoding protein Family with sequence similarity 170 member B
- FAM188A: family with sequence similarity 188, member A
- FAM213A: family with sequence similarity 213, member A
- FAM25BP encoding protein Protein FAM25
- FAS-AS1, long non-coding RNA
- FGFR2: fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, JacksonWeiss syndrome)
- FRA10AC1: Fragile site, folic acid type
- FRAT1: WNT signaling pathway regulator
- FRAT2: WNT signaling pathway regulator
- FRMPD2 encoding protein FERM and PDZ domain containing 2
- GATA3: encoding the GATA3 transcription factor. GATA3 is critical for the embryonic development of the parathyroid gland, neural component of hearing, and kidney. Haploinsufficiency of the gene underlies a rare disorder, the hypoparathyrodism, deafness, and renal dysplasia syndrome
- GHITM: growth hormone-inducible transmembrane protein
- GPRIN2: G protein-regulated inducer of neurite outgrowth 2
- GTPBP4: Nucleolar GTP-binding protein 4
- HELLS: Lymphoid-specific helicase
- HKDC1: hexokinase domain containing 1
- KIN: DNA/RNA-binding protein KIN17
- MTG1: mitochondrial GTPase 1
- NPM3: nucleoplasmin-3
- NRBF2: nuclear receptor-binding factor 2
- NSMCE4A: non-SMC element 4 homolog A
- OTUD1: encoding protein OTU deubiquitinase 1
- PCBD1: 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)
- PCDH15: protocadherin 15
- PI4K2A: phosphatidylinositol 4-kinase 2-alpha
- PIP4K2A: phosphatidylinositol 5 phosphate 4-kinase type-2 alpha
- PITRM1: pitrilysin metallopeptidase 1
- PLEKHS1 encoding protein Pleckstrin homology domain containing S1
- PLXDC2: plexin domain-containing protein 2
- PROSER2: proline and serine rich 2 or c10orf47
- PTEN gene: phosphatase and tensin homolog (mutated in multiple advanced cancers 1)
- RET: ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
- RPP30: ribonuclease P protein subunit p30
- RRP12: ribosomal RNA processing 12 homolog
- RSU1: ras suppressor protein 1
- SGPL1: sphingosine-1-phosphate lyase 1
- SMNDC1: survival motor neuron domain containing 1
- SPG9 encoding protein Spastic paraplegia 9 (autosomal dominant)
- SRGN: serglycin
- STAMBPL1: STAM binding protein like 1
- STOX1: encoding protein Storkhead box 1
- SUPV3L1: Suv3 like RNA helicase
- TACC2 encoding protein Transforming acidic coiled-coil-containing protein 2
- TBC1D12: TBC1 domain family, member 12
- TCTN3: tectonic family member 3
- TMEM10: opalin
- TMEM26: encoding protein Transmembrane protein 26
- UCN3: urocortin-3
- UROS: uroporphyrinogen III synthase (congenital erythropoietic porphyria)
- USP6NL: USP6 N-terminal like protein
- UTF1: undifferentiated embryonic cell transcription factor 1
- WASHC2C: WASH complex subunit 2C
- WBP1L: WW domain binding protein 1-like
- ZNF37A: zinc finger protein 37A
- ZNF438: zinc finger protein 438

# Diseases and disorders
The following diseases are related to genes on chromosome 10:
- Apert syndrome
- BeareStevenson cutis gyrata syndrome
- CharcotMarieTooth disease
- Cockayne syndrome
- congenital erythropoietic porphyria
- Cowden syndrome
- Crouzon syndrome
- Glioblastoma Multiforme
- HermanskyPudlak syndrome
- Hirschprung disease
- JacksonWeiss syndrome
- multiple endocrine neoplasia type 2
- nonsyndromic deafness
- Pfeiffer syndrome
- porphyria
- tetrahydrobiopterin deficiency
- ThielBehnke corneal dystrophy
- Usher syndrome
- Wolman syndrome

# Cytogenetic band