FCAR
Fc fragment of IgA receptor (FCAR) is a human gene that codes for the transmembrane receptor FcRI, also known as CD89 (Cluster of Differentiation 89). FcRI binds the heavy-chain constant region of Immunoglubulin A (IgA) antibodies. FcRI is present on the cell surface of myeloid lineage cells, including neutrophils, monocytes, macrophages, and eosinophils, though it is notably absent from intestinal macrophages and does not appear on mast cells. FcRI plays a role in both pro- and anti-inflammatory responses depending on the state of IgA bound. Inside-out signaling primes FcRI in order for it to bind its ligand, while outside-in signaling caused by ligand binding depends on FcRI association with the Fc receptor gamma chain (FcR -chain).
Though FcRI is part of the Fc receptor immunoglobulin superfamily, the proteins primary structure is similar to receptors in the leukocyte receptor cluster (LRC), and the FCAR gene appears amidst LRC genes on chromosome 19. This contrasts with the location of other members of the Fc receptor immunoglobulin superfamily, which are encoded on chromosome 1. Additionally, though there are equivalents to FCAR in several species, there is no such homolog in mice.

# Structure
The FcRI -chain consists of two extracellular domains, EC1 and EC2, at a right angle to each other, a transmembrane domain, and an intracellular domain. However, this chain alone cannot perform signaling in response to IgA binding, and FcRI must associate with a dimeric form of FcR g-chain, the ends of which contain immunoreceptor tyrosine-based activation motifs (ITAMs). The FcR -chain is responsible for relaying the signal to the inside of the cell.
Two FCAR alleles differing by a single nucleotide polymorphism (SNP) code for two FcRI molecules that differ in their ability to signal for IL-6 and TNF- production and release. The SNP results in either serine or glycine as the 248th residue of the amino acid sequence, a position in the intracellular domain of FcRI. Compared to FcRI with Ser248, FcRI molecules with Gly248 are better able to signal for the release of IL-6, even independently from FcR -chain association.
Alternative splicing of the transcript from this gene produces ten mRNA variants encoding different isoforms.

# Inside-Out Signaling
FcRI must first be primed by a process called inside-out signaling in order to bind with increased ability to IgA. Priming occurs when cytokines signaling the presence of an infection bind their receptors on FcRI-expressing cells, activating the kinase PI3K. PI3K then activates p38 and PKC, which together with PP2A lead to the dephosphorylation of the Serine 263 residue (Ser263) on the intracellular domain of the FcRI -chain. The priming of FcRI to be able to bind IgA does not depend on FcRI association with the FcR -chain, but does depend on cytoskeleton organization.
Once primed, FcRI can bind IgA. The FcRI EC1 domain binds the hinge between the IgA-Fc regions Ca2 and Ca3 regions.

# Function
Signaling and the resulting cellular response caused by FcRI binding IgA varies depending on the state of the IgA molecules. A pro-inflammatory response is signaled when IgA molecules in an immune complex bind to multiple FcRI, resulting in the activation of Src family kinases and the phosphorylation of the FcR -chain ITAMs by Lyn. Syk, a tyrosine kinase, subsequently docks at the phosphorylated ITAMs and initiates PI3K and PLC- signaling. The ensuing signaling cascades lead to pro-inflammatory responses such as release of cytokines, phagocytosis, respiratory bursts, antibody-dependent cell-mediated cytotoxicity, production of reactive oxygen species, and antigen presentation.
Despite signaling via ITAMs, which typically initiate activation cascades, FcRI may either act as an activating or inhibitory receptor. Inhibitory ITAM signaling (ITAMi) results in anti-inflammatory responses. When FcRI monovalently binds monomeric, non-antigen bound IgA, the form most common in serum, the resulting signals result in inactivation of other activating receptors such as FcR and FcRI. The binding of the monomeric serum IgA causes Lyn to only partly phosphorylate the FcR -chain ITAMs. Consequently, Src homology region 2 domain-containing phosphatase-1 (SHP-1) is recruited by Syk to the FcR -chain. A tyrosine phosphatase, SHP-1 coordinates the anti-inflammatory response, preventing other receptors from signaling for pro-inflammatory responses by not allowing these receptors to become phosphorylated. This ITAMi signaling supports homeostasis in the absence of pathogens.
The anti-inflammatory role of monomeric IgA-FcRI binding may have implications for treatment of allergic asthma, as shown by targeting FcRI in transgenic mice models with anti-FcRI Fab antibodies, which mimic the binding of monomeric IgA. This FcRI targeting led to decreased infiltration of airway tissue by inflammatory leukocytes.
The secreted form of IgA (sIgA), a homodimer secreted across epithelial linings such as the gut epithelium, is sterically hindered in its binding to FcRI. This is because some of sIgAs FcRI binding site is obscured by a section of the cleaved polymeric Ig receptor that aided sIgAs secretion into the gut lumen. However, the precursor to sIgA, dimeric IgA (dIgA), binds to FcRI with approximately the same affinity as monomeric IgA. Secreted IgA plays an important role in preventing immune response to commensal gut microbes, and accordingly intestinal macrophages do not express FcRI. However, during invasion of mucosal tissue by pathogenic bacteria, neutrophils responding to the infection will bind and phagocytose dIgA-opsonized bacteria via FcRI.
FcRI is also an important Fc receptor for neutrophil killing of tumor cells. When FcRI-expressing neutrophils come into contact with IgA-opsinized tumor cells, the neutrophils not only perform antibody-dependent cell-mediated cytotoxicity, but also release the cytokines TNF- and IL-1 which cause increased neutrophil migration to the site.

# Interactions
FCAR has been shown to interact with FCGR1A.