Sandbox id01

# Musculoskeletal

## Osteomyelitis

### Candidal osteomyelitis
- Preferred Regimen
Fluconazole 400 mg (6 mg/kg) IV/po daily OR Lipid-based Amphotericin B 3-5 mg/kg daily for two weeks, followed by Fluconazole
- Fluconazole 400 mg (6 mg/kg) IV/po daily OR Lipid-based Amphotericin B 3-5 mg/kg daily for two weeks, followed by Fluconazole
- Alternative Regimen
Caspofungin 70 mg loading dose, then 50 mg/day IV OR Micafungin 100 mg/day IV or Anidulafungin 200 mg IV loading dose, then 100 mg/day IV
- Caspofungin 70 mg loading dose, then 50 mg/day IV OR Micafungin 100 mg/day IV or Anidulafungin 200 mg IV loading dose, then 100 mg/day IV

### Chronic osteomyelitis
- Preferred Regimen
Systemic antibiotics per culture and susceptibility results AND
Surgical debridement
- Systemic antibiotics per culture and susceptibility results AND
- Surgical debridement

### Contiguous with vascular insufficiency
- Preferred Regimen
Systemic antibiotics per culture and susceptibility results AND
Surgical debridement AND
Revascularization if possible
- Systemic antibiotics per culture and susceptibility results AND
- Surgical debridement AND
- Revascularization if possible

### Contiguous without vascular insufficiency
- Preferred Regimen
Vancomycin 1 gm IV q12h AND
Ceftazidime 2 gm IV q8h OR Cefepime 2 gm IV q12h
- Vancomycin 1 gm IV q12h AND
- Ceftazidime 2 gm IV q8h OR Cefepime 2 gm IV q12h
- Alternative Regimen
Linezolid 600 mg po/IV bid AND
Ceftazidime 2 gm IV q8h OR Cefepime 2 gm IV q12h
- Linezolid 600 mg po/IV bid AND
- Ceftazidime 2 gm IV q8h OR Cefepime 2 gm IV q12h
- Gram-negative bacilli
Ciprofloxacin 750 mg po bid OR Linezolid 600 mg po/IV bid
- Ciprofloxacin 750 mg po bid OR Linezolid 600 mg po/IV bid
- Staphylococcus aureus (MRSA/MSSA)
Ciprofloxacin 750 mg po bid OR Levofloxacin 750 mg po once daily if susceptible AND
Rifampin 300-450 mg po bid OR Rifampin 600 mg po once daily if susceptible
- Ciprofloxacin 750 mg po bid OR Levofloxacin 750 mg po once daily if susceptible AND
- Rifampin 300-450 mg po bid OR Rifampin 600 mg po once daily if susceptible
- MSSA
Nafcillin 2 gm IV q4h OR Oxacillin 2 gm IV q4h OR Cefazolin 2 gm IV q8h
- Nafcillin 2 gm IV q4h OR Oxacillin 2 gm IV q4h OR Cefazolin 2 gm IV q8h
- MRSA
Vancomycin 15-20 mg/kg IV q8-12h targeting trough concentrations of 15-20 mg/L
- Vancomycin 15-20 mg/kg IV q8-12h targeting trough concentrations of 15-20 mg/L

### Diabetic foot
- Chronic infection
Levofloxacin 750 mg IV/PO q24h OR Cefoxitin 1 g IV q4h (or 2 g IV q68h) OR Ceftriaxone 12 g/day IV/IM q1224h OR Ampicillin-Sulbactam 1.53 g IV/IM q6h OR Moxifloxacin 400 mg IV/PO q24h OR Ertapenem 1 g IV/IM q24h OR Tigecycline 100 mg IV, then 50 mg IV q12h OR Imipenem-Cilastatin 0.51 g IV q68h
- Levofloxacin 750 mg IV/PO q24h OR Cefoxitin 1 g IV q4h (or 2 g IV q68h) OR Ceftriaxone 12 g/day IV/IM q1224h OR Ampicillin-Sulbactam 1.53 g IV/IM q6h OR Moxifloxacin 400 mg IV/PO q24h OR Ertapenem 1 g IV/IM q24h OR Tigecycline 100 mg IV, then 50 mg IV q12h OR Imipenem-Cilastatin 0.51 g IV q68h
- Recent antibiotic use
Levofloxacin 750 mg IV/PO q24h OR Cefoxitin 1 g IV q4h (or 2 g IV q68h) OR Ceftriaxone 12 g/day IV/IM q1224h OR Ampicillin-Sulbactam 1.53 g IV/IM q6h OR Moxifloxacin 400 mg IV/PO q24h OR Ertapenem 1 g IV/IM q24h OR Tigecycline 100 mg IV, then 50 mg IV q12h OR Imipenem-Cilastatin 0.51 g IV q68h
- Levofloxacin 750 mg IV/PO q24h OR Cefoxitin 1 g IV q4h (or 2 g IV q68h) OR Ceftriaxone 12 g/day IV/IM q1224h OR Ampicillin-Sulbactam 1.53 g IV/IM q6h OR Moxifloxacin 400 mg IV/PO q24h OR Ertapenem 1 g IV/IM q24h OR Tigecycline 100 mg IV, then 50 mg IV q12h OR Imipenem-Cilastatin 0.51 g IV q68h
- High Risk for MRSA
Linezolid 600 mg IV/PO q12h OR Daptomycin 4 mg/kg IV q24h OR Vancomycin 1520 mg/kg IV q812h (trough: 1020 mg/L)
- Linezolid 600 mg IV/PO q12h OR Daptomycin 4 mg/kg IV q24h OR Vancomycin 1520 mg/kg IV q812h (trough: 1020 mg/L)
- High Risk for Pseudomonas aeruginosa
PiperacillinTazobactam 3.375 g IV q68h
- PiperacillinTazobactam 3.375 g IV q68h
- Polymicrobial Infection
(Vancomycin 1520 mg/kg IV q812h OR Linezolid 600 mg IV/PO q12h OR Daptomycin 4 mg/kg IV q24h) AND
(PiperacillinTazobactam 3.375 g IV q68h OR Imipenem-Cilastatin 0.51 g IV q68h OR Ertapenem 1 g IV/IM q24h OR Meropenem 1 g IV/IM q24h) OR (Metronidazole 15 mg/kg IV, then 7.5 mg/kg IV q6h PLUS Ceftazidime 2 g IV q8h OR Cefepime 2 g IV q8h OR Aztreonam 2 g IV q68h)
- (Vancomycin 1520 mg/kg IV q812h OR Linezolid 600 mg IV/PO q12h OR Daptomycin 4 mg/kg IV q24h) AND
- (PiperacillinTazobactam 3.375 g IV q68h OR Imipenem-Cilastatin 0.51 g IV q68h OR Ertapenem 1 g IV/IM q24h OR Meropenem 1 g IV/IM q24h) OR (Metronidazole 15 mg/kg IV, then 7.5 mg/kg IV q6h PLUS Ceftazidime 2 g IV q8h OR Cefepime 2 g IV q8h OR Aztreonam 2 g IV q68h)

### Foot bone
- Preferred Regimen
Ciprofloxacin 750 mg po bid OR Levofloxacin 750 mg po q24h
- Ciprofloxacin 750 mg po bid OR Levofloxacin 750 mg po q24h
- Alternative Regimen
Ceftazidime 2 gm IV q8h OR Cefepime 2 gm IV q8h OR Meropenem 1 gm IV q8h
- Ceftazidime 2 gm IV q8h OR Cefepime 2 gm IV q8h OR Meropenem 1 gm IV q8h

### Foot puncture wound
- Preferred Regimen
Cleanse wound AND
Tetanus booster if due AND
X-ray to exclude presence of radio-opaque foreign body
- Cleanse wound AND
- Tetanus booster if due AND
- X-ray to exclude presence of radio-opaque foreign body

### Hematogenous
- Preferred Regimen
MRSA likely  Vancomycin 1520 mg/kg IV q812h AND (Ceftriaxone 12 g/day IV/IM q1224h OR Ceftazidime 2 gm IV q8h OR Cefepime 2 gm IV q12h)
MRSA unlikely  (Nafcillin OR Oxacillin) AND (Ceftriaxone 12 g/day IV/IM q1224h OR Ceftazidime 2 gm IV q8h OR Cefepime 2 gm IV q12h)
- MRSA likely  Vancomycin 1520 mg/kg IV q812h AND (Ceftriaxone 12 g/day IV/IM q1224h OR Ceftazidime 2 gm IV q8h OR Cefepime 2 gm IV q12h)
- MRSA unlikely  (Nafcillin OR Oxacillin) AND (Ceftriaxone 12 g/day IV/IM q1224h OR Ceftazidime 2 gm IV q8h OR Cefepime 2 gm IV q12h)
- Alternative Regimen
Linezolid 600 mg po/IV bid OR Daptomycin 4 mg/kg IV q24h to replace vancomycin
Ciprofloxacin 750 mg po bid OR Levofloxacin 750 mg IV/PO q24h OR Aztreonam 2 g IV q68h to replace a third-generation cephalosporin
- Linezolid 600 mg po/IV bid OR Daptomycin 4 mg/kg IV q24h to replace vancomycin
- Ciprofloxacin 750 mg po bid OR Levofloxacin 750 mg IV/PO q24h OR Aztreonam 2 g IV q68h to replace a third-generation cephalosporin

### Hemoglobinopathy
- Preferred Regimen
Ciprofloxacin 400 mg IV q12h OR Ceftriaxone 2 gm IV q24h
- Ciprofloxacin 400 mg IV q12h OR Ceftriaxone 2 gm IV q24h
- Alternative Regimen
Ciprofloxacin 750 mg po bid for 6 weeks OR Levofloxacin 750 mg po q24h for 6 weeks
- Ciprofloxacin 750 mg po bid for 6 weeks OR Levofloxacin 750 mg po q24h for 6 weeks

### Prosthetic joint infection
- MSSA/MSSE
(Nafcillin 2 gm IV q4h OR Oxacillin 2 gm IV q4h IV) PLUS Rifampin 300 mg po bid OR
Cefazolin 2 gm IV q8h PLUS Rifampin 300 mg po bid for 2-6 weeks followed by (Ciprofloxacin 750 mg po bid OR Levofloxacin 750 mg po q24h) PLUS Rifampin 300 mg po bid for 3-6 months
- (Nafcillin 2 gm IV q4h OR Oxacillin 2 gm IV q4h IV) PLUS Rifampin 300 mg po bid OR
- Cefazolin 2 gm IV q8h PLUS Rifampin 300 mg po bid for 2-6 weeks followed by (Ciprofloxacin 750 mg po bid OR Levofloxacin 750 mg po q24h) PLUS Rifampin 300 mg po bid for 3-6 months
- MRSA/MRSE
Vancomycin 15-20 mg/kg IV q8-12h PLUS Rifampin 300 mg po bid for 2-6 weeks followed by (Ciprofloxacin 750 mg po bid OR Levofloxacin 750 mg po q24h) PLUS Rifampin 300 mg po bid for 3-6 months
- Vancomycin 15-20 mg/kg IV q8-12h PLUS Rifampin 300 mg po bid for 2-6 weeks followed by (Ciprofloxacin 750 mg po bid OR Levofloxacin 750 mg po q24h) PLUS Rifampin 300 mg po bid for 3-6 months
- Streptococcus
Penicillin G 20 million units IV continuous infusion q24h or in 6 divided doses OR Ceftriaxone 2 gm IV q24h x 4-6 weeks
- Penicillin G 20 million units IV continuous infusion q24h or in 6 divided doses OR Ceftriaxone 2 gm IV q24h x 4-6 weeks
- Enterococcus
Penicillin-susceptible  Ampicillin 12 gm IV OR Penicillin G 20 million units IV continuous infusion q24h or in 6 divided doses x 4-6 weeks
Penicillin-resistant  Vancomycin 15 mg/kg IV q12h x 4-6 week
- Penicillin-susceptible  Ampicillin 12 gm IV OR Penicillin G 20 million units IV continuous infusion q24h or in 6 divided doses x 4-6 weeks
- Penicillin-resistant  Vancomycin 15 mg/kg IV q12h x 4-6 week
- Propionibacterium acnes
Penicillin G 20 million units IV continuous infusion or in 6 divided doses OR Ceftriaxone 2 gm IV q24h x 4-6 weeks
- Penicillin G 20 million units IV continuous infusion or in 6 divided doses OR Ceftriaxone 2 gm IV q24h x 4-6 weeks
- Gram-negative enteric bacilli
Ertapenem 1 gm q24h IV OR Ceftriaxone 2 gm IV q24h OR Cefepime 2 gm IV q12h for 4-6 weeks
- Ertapenem 1 gm q24h IV OR Ceftriaxone 2 gm IV q24h OR Cefepime 2 gm IV q12h for 4-6 weeks
- Pseudomonas aeruginosa
Cefepime 2 gm IV q12h OR Meropenem 1 gm IV q8h for 4-6 weeks AND
Tobramycin 5.1 mg/kg once daily IV for 4-6 weeks
- Cefepime 2 gm IV q12h OR Meropenem 1 gm IV q8h for 4-6 weeks AND
- Tobramycin 5.1 mg/kg once daily IV for 4-6 weeks

### Spinal implant
- MSSA/MSSE
(Nafcillin 2 gm IV q4h OR Oxacillin 2 gm IV q4h IV) PLUS Rifampin 300 mg po bid OR
Cefazolin 2 gm IV q8h PLUS Rifampin 300 mg po bid for 2-6 weeks followed by (Ciprofloxacin 750 mg po bid OR Levofloxacin 750 mg po q24h) PLUS Rifampin 300 mg po bid for 3-6 months
- (Nafcillin 2 gm IV q4h OR Oxacillin 2 gm IV q4h IV) PLUS Rifampin 300 mg po bid OR
- Cefazolin 2 gm IV q8h PLUS Rifampin 300 mg po bid for 2-6 weeks followed by (Ciprofloxacin 750 mg po bid OR Levofloxacin 750 mg po q24h) PLUS Rifampin 300 mg po bid for 3-6 months
- MRSA/MRSE
Vancomycin 15-20 mg/kg IV q8-12h PLUS Rifampin 300 mg po bid for 2-6 weeks followed by (Ciprofloxacin 750 mg po bid OR Levofloxacin 750 mg po q24h) PLUS Rifampin 300 mg po bid for 3-6 months
- Vancomycin 15-20 mg/kg IV q8-12h PLUS Rifampin 300 mg po bid for 2-6 weeks followed by (Ciprofloxacin 750 mg po bid OR Levofloxacin 750 mg po q24h) PLUS Rifampin 300 mg po bid for 3-6 months
- Streptococcus
Penicillin G 20 million units IV continuous infusion q24h or in 6 divided doses OR Ceftriaxone 2 gm IV q24h x 4-6 weeks
- Penicillin G 20 million units IV continuous infusion q24h or in 6 divided doses OR Ceftriaxone 2 gm IV q24h x 4-6 weeks
- Enterococcus
Penicillin-susceptible  Ampicillin 12 gm IV OR Penicillin G 20 million units IV continuous infusion q24h or in 6 divided doses x 4-6 weeks
Penicillin-resistant  Vancomycin 15 mg/kg IV q12h x 4-6 week
- Penicillin-susceptible  Ampicillin 12 gm IV OR Penicillin G 20 million units IV continuous infusion q24h or in 6 divided doses x 4-6 weeks
- Penicillin-resistant  Vancomycin 15 mg/kg IV q12h x 4-6 week
- Propionibacterium acnes
Penicillin G 20 million units IV continuous infusion or in 6 divided doses OR Ceftriaxone 2 gm IV q24h x 4-6 weeks
- Penicillin G 20 million units IV continuous infusion or in 6 divided doses OR Ceftriaxone 2 gm IV q24h x 4-6 weeks
- Gram-negative enteric bacilli
Ertapenem 1 gm q24h IV OR Ceftriaxone 2 gm IV q24h OR Cefepime 2 gm IV q12h for 4-6 weeks
- Ertapenem 1 gm q24h IV OR Ceftriaxone 2 gm IV q24h OR Cefepime 2 gm IV q12h for 4-6 weeks
- Pseudomonas aeruginosa
Cefepime 2 gm IV q12h OR Meropenem 1 gm IV q8h for 4-6 weeks AND
Tobramycin 5.1 mg/kg once daily IV for 4-6 weeks
- Cefepime 2 gm IV q12h OR Meropenem 1 gm IV q8h for 4-6 weeks AND
- Tobramycin 5.1 mg/kg once daily IV for 4-6 weeks

### Sternal
- Preferred Regimen
Vancomycin 15-30 mg/kg IV q 8-12h targeting trough of 15-20 g/mL OR Nafcillin 2 gm IV q4h
- Vancomycin 15-30 mg/kg IV q 8-12h targeting trough of 15-20 g/mL OR Nafcillin 2 gm IV q4h
- Alternative Regimen
Linezolid 600 mg IV/po bid
- Linezolid 600 mg IV/po bid

## Bursitis
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

## Lyme arthritis
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

## Reactive arthritis
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

### Reiter's syndrome
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

### Post-streptococcal arthritis
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

## Septic arthritis
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

### Brucellosis
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

### Candida
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

### Gonococcal, disseminated infection
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

### Gram-negative bacilli
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

### Histoplasmosis
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

### Lyme disease
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

### Mycobacterium tuberculosis
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

### Pneumococcal
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

### Staphylococcal
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

### Streptococcal
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

### Post-intraarticular injection
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

## Gangrene
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

## Myonecrosis
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

## Necrotizing fascitis
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

### Clostridial
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

### Staphylococcal
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

### Streptococcal
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

### Synergistic
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration

## Pyomyositis
- Preferred Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Alternative Regimen
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration AND
- Drug DosageRouteFrequencyDuration OR Drug DosageRouteFrequencyDuration