Sucralose
Sucralose is an artificial sweetener.  In the European Union, it is also known under the E number (additive code) E955. Sucralose was originally sold under the trade name Splenda. It is now also supplied by a variety of manufacturers and brands. Sucralose  is approximately 600 times as sweet as sucrose (table sugar), twice as sweet as saccharin, and four times as sweet as aspartame.  Unlike aspartame, it is stable under heat and over a broad range of pH conditions and can be used in baking or in products that require a longer shelf life. Sucralose also does not promote tooth decay. Since its introduction in 1999, sucralose has overtaken Equal in the $1.5 billion artificial sweetener market, holding a 62% market share.  According to market research firm IRI, as reported in the Wall Street Journal, Splenda sold $212 million in 2006 in the U.S. while Equal sold $48.7 million.

# History
Sucralose was discovered in 1976 by scientists from Tate & Lyle, working with researchers Leslie Hough and Shashikant Phadnis at Queen Elizabeth College (now part of King's College London). The duo were trying to test chlorinated sugars as chemical intermediates.  On a late-summer day, Phadnis was told to test the powder. Phadnis thought that Hough asked him to taste it, so he did.  He found the compound to be exceptionally sweet (the final formula was 600 times as sweet as sugar). They worked with Tate & Lyle for a year before settling down on the final formula.
It was first approved for use in Canada (marketed as Splenda) in 1991.  Subsequent approvals came in Australia in 1993, in New Zealand in 1996, in the United States in 1998, and in the European Union in 2004.  As of 2008, it had been approved in over 80 countries, including Mexico, Brazil, China, India and Japan.
Tate & Lyle manufactures sucralose at a plant in McIntosh, Alabama, with additional capacity under construction in Jurong, Singapore.  It is manufactured by the selective chlorination of sucrose, in which three of the hydroxyl groups are replaced with chlorine atoms to produce sucralose. An alternative pathway is to selectively chlorinate raffinose.
It is used in products such as candy, breakfast bars and soft drinks.  It is also used in canned fruits wherein water and sucralose take the place of much higher calorie corn syrup based additives. Sucralose mixed with maltodextrin and dextrose (both made from corn) as a filler is sold internationally by McNeil Nutritionals under the Splenda brand name. In the United States and Canada, this blend is increasingly found in restaurants, including McDonalds and Starbucks, in yellow packets, in contrast to the pink packets commonly used by saccharin sweeteners and the blue packets used by those containing aspartame; though in Canada yellow packets are also associated with the SugarTwin brand of cyclamate sweetener.

# Packaging and storage
Most products that contain sucralose add fillers and additional sweetener to bring the product to the approximate volume and texture of an equivalent amount of sugar. This is because sucralose is nearly 600 times as sweet as sucrose (table sugar). Pure sucralose is sold in bulk, but not in quantities suitable for individual use, although some highly concentrated sucralose-water blends are available online, using 1/4 tsp per 1 cup of sweetness or roughly 1 part sucralose to 2 parts water. Pure dry sucralose undergoes some decomposition at elevated temperatures. When it is in solution or blended with maltodextrin, it is slightly more stable.

# Energy (caloric) content
Though marketed in the U.S. as a No calorie sweetener, Splenda actually contains about 86% of the calories as the same mass of sugar  (331 calories per 100 g vs. 387 calories per 100 g for sugar). However, since Splenda is about 14.5% as dense as sugar, a given volume of Splenda has 12.4% the energy of the same volume of sugar. When sucralose is added directly to commercial products, the filler is omitted and no energy is added.
Note too that although the nutritional facts label on Splendas retail packaging states that a single serving of 0.5 gram (1 teaspoon or 5 milliliters) contains zero calories, Splenda actually contains 1.66 calories per teaspoon. Note that the individual, tear-open packages are double-size, one-gram servings, which contain 3.31 calories. Such labeling is appropriate in the U.S. because the FDAs regulations permit a product to be labeled as zero calories if the food contains less than 5 calories per reference amount customarily consumed and per labeled serving. Because Splenda contains a relatively small amount of sucralose, little of which is metabolized, virtually all of Splendas caloric content derives from the highly fluffed dextrose or maltodextrin filler, or carrier, that gives Splenda its volume. Like other carbohydrates, dextrose and maltodextrin have 3.75 calories per gram.

# Use in branded products
Sucralose can be found in more than 4,500 food and beverage products.  Sucralose is used as a replacement for, or in combination with, other artificial or natural sweeteners such as aspartame, acesulfame potassium or high-fructose corn syrup.
Sucralose is marketed in India by Zydus Cadila under the brand name Sugar free Natura and by Hexagon Group under brand name Kal Tame.

# Cooking
Sucralose is a highly heat-stable artificial sweetener, allowing it to be used in many recipes without any use of sugar.  Sucralose is available in a granulated form that allows for volume-for-volume substitution with sugar. This mix of sucralose and fillers rapidly dissolves in liquids. However, while it provides volume-for-volume sweetness, the texture may be noticeably different.

# Safety
Sucralose has been accepted by several national and international food safety regulatory bodies, including the U.S. Food and Drug Administration (FDA), Joint Food and Agriculture Organization/World Health Organization Expert Committee on Food Additives, The European Union's Scientific Committee on Food, Health Protection Branch of Health and Welfare Canada and Food Standards Australia-New Zealand (FSANZ).  According to the Canadian Diabetes Association, one can consume 15 mg/kg/day of Sucralose "on a daily basis over a ... lifetime without any adverse effects". For a 150 lb person, 15 mg/kg is about 1000 mg, equivalent to about 75 packets of Splenda or the sweetness of 612 gm or 2500 kcal of sugar.
In determining the safety of sucralose, the FDA reviewed data from more than 110 studies in humans and animals. Many of the studies were designed to identify possible toxic effects including carcinogenic, reproductive and neurological effects. No such effects were found, and FDA's approval is based on the finding that sucralose is safe for human consumption.  For example, McNeil Nutritional LLC studies submitted as part of its U.S. FDA Food Additive Petition 7A3987, indicated that "in the 2-year rodent bioassays...there was no evidence of carcinogenic activity for either sucralose or its hydrolysis products...."
After FDA approval, a study published in the Journal of Head and Face Pain reported sucralose as a possible trigger for migraine patients.  Another study published in the Journal of Mutation Research linked high doses (2000 mg per kg; equal to 10,000 packets per day for the 150 lb person in the above example) of sucralose to DNA damage in mice.
Concerns have been raised about the effect of sucralose on the thymus, an organ that is important to the immune system. A report from NICNAS cites two studies on rats, both of which found "a significant decrease in mean thymus weight" at a certain dose.  The sucralose dosages which caused the thymus gland effects referenced in the NICNAS report was 3000 mg/kg bw/day for 28 days.  For an 80 kg (176 lb) human, this would mean a 28-day intake of 240 grams of sucralose, which is equivalent to more than 20,000 individual Splenda packets/day for approximately one month.  The dose required to provoke any immunological response was 750 mg/kg bw/day, or 60 grams of sucralose per day, which is more than 5,000 Splenda packets/day (there are 11.9 mg of sucralose in a 1g retail packet of Splenda).  These and other studies were considered by regulators before concluding that sucralose was safe. However, because some ingested sucralose is broken down and absorbed by the body there is concern that chronic consumption may lead to thymus shrinkage or other side-effects.
There have been anecdotal reports of "allergic" reactions and other adverse reactions to Splenda. 
The bulk of sucralose ingested does not leave the gastrointestinal tract and is directly excreted in the feces while 11-27% of it is absorbed. The amount that is absorbed from the GI tract is largely removed from the blood stream by the kidneys and excreted in the urine with 20-30% of the absorbed sucralose being metabolized. According to one study, sucralose is digestible by a number of microorganisms and is broken down once released into the environment. However, measurements by the Swedish Environmental Research Institute have shown that wastewater treatment has little effect on sucralose, which is present in wastewater effluents at levels of several g/l. There are no known eco-toxicological effects at such levels, but the Swedish Environmental Protection Agency warns that there may be a continuous increase in levels if the compound is only slowly degraded in nature.
Splenda usually contains 95% dextrose (the "right-handed" isomer of glucose - see dextrorotation and chirality), which the body readily metabolizes.  The safety information that many specialists and the media give to consumers is that Splenda is safe to ingest as a diabetic sugar substitute.

## Natural alternatives
Critics of sucralose often favor natural alternatives, including xylitol, maltitol, thaumatin, isomalt and stevia.  However, those substances raise other health concerns, and natural products generally do not undergo controlled trials before being allowed in food.

## Organochlorides
The basis for concern about the safety of sucralose derives from the class of chemical to which it belongs.  The sucralose molecule is an organochloride (or chlorocarbon). Since some organochlorides are known to cause adverse health effects in extremely small concentrations, critics of sucralose feel the extra-high burden of proof is warranted.  Although some chlorocarbons are toxic, sucralose is not known to be toxic in small quantities and is extremely insoluble in fat; it can not accumulate in fat like chlorinated hydrocarbons. In addition, sucralose does not break down or dechlorinate.
In contrast to these concerns, many organochlorides occur naturally in food sources such as seaweed.

## Effect on weight gain
Artificial sweetners including sucralose have been identified as possible factors in raising population obesity levels by making the consumer take up more calories later, because it confuses the brain and body responses about sugary substances and calories - associating sweet foods with fewer calories.

# Marketing controversy
In 2006 Merisant, the maker of Equal, filed suit against McNeil Nutritionals in federal court in Philadelphia alleging that Splenda's tagline "Made from sugar, so it tastes like sugar" is false and misleading and Merisant's website calls it an urban myth.  McNeil argued during the trial that it had never deceived consumers or set out to deceive them, since the product did in fact start out with sugar.  Merisant asked that McNeil be ordered to surrender profits and modify its advertising.  The case ended with an agreement reached outside of court, with undisclosed settlement conditions.
The lawsuit was the latest move in a long-simmering dispute.  In 2004, Merisant filed a complaint with the Better Business Bureau regarding McNeil's advertising. McNeil alleged that Merisant's complaint was in retaliation for a ruling in federal court in Puerto Rico, which forced Merisant to stop packaging Equal in packages resembling Splenda's. McNeil filed suit in Puerto Rico seeking a ruling which would declare its advertising to not be misleading.  Following Merisant's lawsuit in Philadelphia, McNeil agreed to a jury trial and to the dismissal of its lawsuit in Puerto Rico.
In 2007, Merisant France won a significant victory in the Commercial Court of Paris against subsidiaries of McNeil Nutritionals LLC, the American company that markets Splenda. 
The court awarded Merisant $54,000 in damages and ordered the defendants to cease advertising claims found to violate French consumer protection laws. The advertising claims found to violate French law and which McNeil must cease include: "Because it comes from sugar, sucralose tastes like sugar" and "With sucralose: Comes from sugar and tastes like sugar". The ruling orders McNeil to amend all advertising and promotions of Splenda that contain these misleading claims and to amend all packaging. The Court prohibited the distribution of any products under the trademark Splenda with unchanged packaging after a period of four months after serving this ruling.
A Sugar Association complaint to the Federal Trade Commission points out that "Splenda is not a natural product. It is not cultivated or grown and it does not occur in nature."  McNeil Nutritionals, the manufacturer of Splenda, has responded that its "advertising represents the products in an accurate and informative manner and complies with applicable advertising rules in the countries where Splenda brand products are marketed."  The U.S. Sugar Association has also started a web site where they put forward their criticism of sucralose.