Sandbox welchol

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# Overview
Sandbox welchol is a Bile acid sequestrant that is FDA approved for the {{{indicationType}}} of primary hyperlipidemia, type 2 diabetes mellitus.   Common adverse reactions include constipation, indigestion, nausea,nasopharyngitis.

# Adult Indications and Dosage

## FDA-Labeled Indications and Dosage (Adult)
- Dosing Information
- one 3.75 gram packet once daily or one 1.875 gram packet twice daily
Welchol is indicated as an adjunct to diet and exercise to reduce elevated low-density lipoprotein cholesterol (LDL-C) in adults with primary hyperlipidemia (Fredrickson Type IIa) as monotherapy or in combination with an hydroxymethyl-glutaryl-coenzyme A (HMG CoA) reductase inhibitor (statin).
Welchol is indicated as monotherapy or in combination with a statin to reduce LDL-C levels in boys and postmenarchal girls, 10 to 17 years of age, with heterozygous familial hypercholesterolemia if after an adequate trial of diet therapy the following findings are present: 
a. LDL-C remains  190 mg/dL or 
b. LDL-C remains  160 mg/dL and
- there is a positive family history of premature cardiovascular disease or
- two or more other CVD risk factors are present in the pediatric patient.
Lipid-altering agents should be used in addition to a diet restricted in saturated fat and cholesterol when response to diet and non-pharmacological interventions alone has been inadequate .
In patients with coronary heart disease (CHD) or CHD risk equivalents such as diabetes mellitus, LDL-C treatment goals are  200 mg/dL, then non-HDL cholesterol (non-HDL-C) (total cholesterol  minus high density lipoprotein cholesterol ) becomes a secondary target of therapy. The goal for non-HDL-C in persons with high serum TG is set at 30 mg/dL higher than that for LDL-C.

## Type 2 Diabetes Mellitus
- Dosing Information
- 6 tablets once daily or 3 tablets twice daily
Welchol is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus .
Diabetes mellitus is considered a CHD risk equivalent. In addition to glycemic control, intensive lipid control is warranted .

## Off-Label Use and Dosage (Adult)

### NonGuideline-Supported Use
- Dosing Information
- 3750 mg/day (combination with ezetimibe and a statin)

# Pediatric Indications and Dosage

## FDA-Labeled Indications and Dosage (Pediatric)
There is limited information regarding Sandbox welchol FDA-Labeled Indications and Dosage (Pediatric) in the drug label.

## Off-Label Use and Dosage (Pediatric)

# Contraindications
There is limited information regarding Sandbox welchol Contraindications in the drug label.

# Warnings
There is limited information regarding Sandbox welchol Warnings' in the drug label.

# Adverse Reactions

## Clinical Trials Experience
There is limited information regarding Sandbox welchol Clinical Trials Experience in the drug label.

## Postmarketing Experience
There is limited information regarding Sandbox welchol Postmarketing Experience in the drug label.

# Drug Interactions
There is limited information regarding Sandbox welchol Drug Interactions in the drug label.

# Use in Specific Populations

### Pregnancy
Pregnancy Category (FDA): 
There is no FDA guidance on usage of Sandbox welchol in women who are pregnant.
Pregnancy Category (AUS): 
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Sandbox welchol in women who are pregnant.

### Labor and Delivery
There is no FDA guidance on use of Sandbox welchol during labor and delivery.

### Nursing Mothers
There is no FDA guidance on the use of Sandbox welchol in women who are nursing.

### Pediatric Use
There is no FDA guidance on the use of Sandbox welchol in pediatric settings.

### Geriatic Use
There is no FDA guidance on the use of Sandbox welchol in geriatric settings.

### Gender
There is no FDA guidance on the use of Sandbox welchol with respect to specific gender populations.

### Race
There is no FDA guidance on the use of Sandbox welchol with respect to specific racial populations.

### Renal Impairment
There is no FDA guidance on the use of Sandbox welchol in patients with renal impairment.

### Hepatic Impairment
There is no FDA guidance on the use of Sandbox welchol in patients with hepatic impairment.

### Females of Reproductive Potential and Males
There is no FDA guidance on the use of Sandbox welchol in women of reproductive potentials and males.

### Immunocompromised Patients
There is no FDA guidance one the use of Sandbox welchol in patients who are immunocompromised.

# Administration and Monitoring

### Administration
There is limited information regarding Sandbox welchol Administration in the drug label.

### Monitoring
There is limited information regarding Sandbox welchol Monitoring in the drug label.

# IV Compatibility
There is limited information regarding the compatibility of Sandbox welchol and IV administrations.

# Overdosage
There is limited information regarding Sandbox welchol overdosage.  If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

# Pharmacology
There is limited information regarding Sandbox welchol Pharmacology in the drug label.

## Mechanism of Action
There is limited information regarding Sandbox welchol Mechanism of Action in the drug label.

## Structure
There is limited information regarding Sandbox welchol Structure in the drug label.

## Pharmacodynamics
There is limited information regarding Sandbox welchol Pharmacodynamics in the drug label.

## Pharmacokinetics
There is limited information regarding Sandbox welchol Pharmacokinetics in the drug label.

## Nonclinical Toxicology
There is limited information regarding Sandbox welchol Nonclinical Toxicology in the drug label.

# Clinical Studies
There is limited information regarding Sandbox welchol Clinical Studies in the drug label.

# How Supplied
There is limited information regarding Sandbox welchol How Supplied in the drug label.

## Storage
There is limited information regarding Sandbox welchol Storage in the drug label.

# Images

## Drug Images

## Package and Label Display Panel

# Patient Counseling Information
There is limited information regarding Sandbox welchol Patient Counseling Information in the drug label.

# Precautions with Alcohol
Alcohol-Sandbox welchol interaction has not been established. Talk to your doctor regarding the effects of taking alcohol with this medication.

# Brand Names
There is limited information regarding Sandbox welchol Brand Names in the drug label.

# Look-Alike Drug Names
There is limited information regarding Sandbox welchol Look-Alike Drug Names in the drug label.

# Drug Shortage Status

# Price