Persius/hicric huggingface dataset:
ST3GAL3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3, also known as ST3GAL3, is a protein which in humans is encoded by the ST3GAL3 gene.

# Function
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Multiple transcript variants encoding several different isoforms have been found for this gene.
Mutations in the ST3GAL3 gene was recently shown to be the cause of autosomal recessive mental retardation 12. Since the mutations disrupt a glycosylation pathway, this disorder may be considererd a congenital disorder of glycosylation.
ST3GAL5
Lactosylceramide alpha-2,3-sialyltransferase is an enzyme that in humans is encoded by the ST3GAL5 gene.
Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene.
Mutations in this gene have also been associated to Salt & Pepper syndrome: an autosomal recessive condition characterized by severe intellectual disability, epilepsy, scoliosis, choreoathetosis, dysmorphic facial features and altered dermal pigmentation. (doi: 10.1093/hmg/ddt434)
ST6GAL1
Beta-galactoside alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GAL1 gene.
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein, which is normally found in the Golgi but which can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CDw75, and CD76. This protein is a member of glycosyltransferase family 29. Three transcript variants encoding two different isoforms have been found for this gene.
Transcripts of ST6GAL1 are found in mouse high endothelial cells of mesenteric lymph node and Peyer's patches, and it could be involved in the B cell homing to Peyer's patches.
ST8SIA1
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase is an enzyme that in humans is encoded by the ST8SIA1 gene.
Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by ST8SIA1 is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29.
In melanocytic cells, ST8SIA1 gene expression may be regulated by MITF.
STARD13
StAR-related lipid transfer domain protein 13 (STARD13) also known as deleted in liver cancer 2 protein (DLC-2) is a protein that in humans is encoded by the STARD13 gene and a member of the DLC family of proteins.

# Function and structure
STARD13 serves as a Rho GTPase-activating protein (GAP), a type of protein that regulates members of the Rho family of GTPases.  It selectively activates RhoA and CDC42 and suppresses cell growth by inhibiting actin stress fiber assembly.
The protein consists of an N-terminal sterile alpha motif (SAM) domain, a serine-rich domain, a RhoGAP domain and at the C-terminus, a StAR-related lipid-transfer domain (START).

# Tissue distribution and pathology
The protein was identified in part through its differential expression in cancers.  A low level of STARD13 was observed in less differentiated hepatocellular carcinoma tissue with higher RhoA expression.  A small patient study finds that the absence of STARD13 in hepatocellular carcinomas correlates with higher levels of RhoA and a poorer prognosis than patients with carcinomas that were STARD13-positive.

# Model organisms
Model organisms have been used in the study of STARD13 function. A conditional knockout mouse line, called Stard13tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program  a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists  at the Wellcome Trust Sanger Institute.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on mutant mice and two significant abnormalities were observed. Female homozygous mutants had an increased susceptibility to Citrobacter infection and displayed a decreased hematocrit and hemoglobin content.
Another study of mice lacking STARD13, found it may promote blood vessel formation (angiogenesis), especially by tumor cells.  The promotion of angiogenesis with the loss of STARD13 occurs through the actions of RhoA.
STK35L1
STK35L1 is a protein that in humans is encoded by the STK35 (serine/threonine kinase 35) gene.
It is a member of the NKF4 (New Kinase Family 4) Ser/Thr kinases (STK) family and classified in group "Other" in the human kinome.
Previously, STK35L1 was named as Clik1 (CLP36 Interacting Kinase 1) based on a study that showed an association of STK35 with CLP36 after overexpression of both proteins in osteosarcoma cells. Clik1 gene described by Vallenius et al. code for a protein of 501 amino acids. Later, Goyal et al. found that coding sequence of the STK35 gene is incomplete. The newly identified sequence of the STK35 gene codes for a protein of 534 amino acids with a N-terminal elongation of 133 amino acids. It has been designated as STK35L1.

# Functions
STK35L1 is predominantly found in the nucleus and the nucleolus.  Nuclear actin was identified as a novel binding partner of STK35L1. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. STK35L1 regulates the expression of  CDKN2A and inhibiting G1- to S-phase transition.Depletion of STK35L1 by siRNA impaired endothelial cell migration. STK35L1 may act as a central kinase linking the cell cycle and migration of endothelial cells.
SULT1C3
Sulfotransferase 1C3, also known as ST1C3, is an enzyme that in humans is encoded by the SULT1C3 gene.

# Function
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members.

# Clinical significance
ST1C3 sulfates large benzylic alcohols such as 1-hydroxymethyl-pyrene to chemically reactive mutagenic sulpho conjugates.
SUPV3L1
ATP-dependent RNA helicase SUPV3L1, mitochondrial is an enzyme that in humans is encoded by the SUPV3L1 gene.

# Model organisms
Model organisms have been used in the study of SUPV3L1 function. A conditional knockout mouse line, called Supv3l1tm1a(EUCOMM)Wtsi was generated as part of the International Knockout Mouse Consortium program  a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists  at the Wellcome Trust Sanger Institute.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. 
Twenty six tests were carried out and three significant phenotypes were reported. All homozygous mutant animals died prior to birth, and therefore none were observed at weaning. The remaining tests were carried out on heterozygous mutant mice and radiography showed female animals had defects in their transverse processes.
Safrole
Safrole is a colorless or slightly yellow oily liquid. It is typically extracted from the root-bark or the fruit of sassafras plants in the form of sassafras oil, or synthesized from other related methylenedioxy compounds.  It is the principal component of brown camphor oil, and is found in small amounts in a wide variety of plants. The Octea cymbarum oil made of the Octea pretiosa,
a plant growing in brazil, and sassafras oil made of the Sassafras albidum, a plant growing in eastern North America, are the main natural sources for safrole. It has a characteristic "candy-shop" aroma.
Safrole was once widely used as a food additive in root beer, sassafras tea, and other common goods.  However, the Food and Drug Administration (FDA) barred the use of safrole after it was shown to be mildly carcinogenic. Today, safrole is also banned for use in soap and perfumes by IFRA.
It is a precursor in the synthesis of the insecticide synergist piperonyl butoxide.  Safrole is used as the main precursor for the clandestine manufacture of MDMA (ecstasy).  The standard synthetic procedure for the production of MDMA from safrole is via isomerization in the presence of a strong base to isosafrole, oxidization to 3,4-methylenedioxy phenyl-2-propanone,  finally a reductive amination with either methylamine (to make MDMA) or ethylamine (to make MDEA) or ammonia (to make MDA).  A newer synthesis method makes use of the Wacker process (palladium(II) chloride catalyst and 1,4-benzoquinone) to oxidize safrole directly to the 3,4-methylenedioxy phenyl-2-propanone intermediate.
It is nearly impossible to obtain large quantities of safrole and/or sassafras oil without arousing the suspicion of law enforcement, as Safrole is currently a List I chemical. Moreover, safrole is listed as a Table I precursor under the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances.
Sativex
Sativex is an oromucosal (mouth) spray developed by the UK company GW Pharmaceuticals for multiple sclerosis patients, who can use it to alleviate neuropathic pain and spasticity. Sativex is distinct from all other pharmaceutically produced cannabinoids currently available because it is derived from botanical material, rather than a solely synthetic process. Sativex is a pharmaceutical product standardised in composition, formulation, and dose. Its principal active cannabinoid components are the cannabinoids: tetrahydrocannabinol (THC) and cannabidiol (CBD). The product is formulated as an oromucosal spray which is administered by spraying into the mouth. Each spray of Sativex delivers a fixed dose of 2.7mg THC and 2.5mg CBD.
Approved by Health Canada under a license with conditions (NOC/c) for prescription use in April 2005, Sativex is the world's first pharmaceutical prescription medicine derived from the cannabis plant. The product is approved in Canada as adjunctive treatment for the symptomatic relief of neuropathic pain in multiple sclerosis. In June 2007, Health Canada issuing a Qualifying Notice for the approval of Sativex in the relief of cancer pain, with the final approval of this indication expected by fall 2007. It is available in the UK as an unlicensed medicine  which enables UK doctors to prescribe the product to individual patients who they consider may benefit. It is also available in Catalonia, Spain, for 600 patients suffering from multiple sclerosis and a number of other conditions under a compassionate access programme (130 of the patients will be people with multiple sclerosis, a further 130 will be patients with neuropathic pain arising from a range of medical conditions, 40 will be suffering from anorexia and malnutrition caused by AIDS, and the remaining 300 will be cancer patients undergoing chemotherapy and suffering from nausea and vomiting).
In February 2007, GW and Otsuka Pharmaceutical announced an exclusive agreement for Otsuka to develop and market Sativex in the United States. Otsuka is a major global pharmaceutical company, best known for its antipsychotic blockbuster medication, Abilify. Sativex has received permission from the US regulatory authority, the FDA, to enter directly into late stage Phase III trials in the US. The first large scale US trial in the US for cancer patients is expected to start in summer 2007.  The 300-patient, double-blind, randomized, placebo-controlled study will evaluate the effect of Sativex in relieving average daily pain, reducing the use of breakthrough opioid medications, improving the quality of sleep and relevant aspects of quality of life among other outcome measures.
In December 2005, GW and the Spanish pharmaceutical company Almirall announced an exclusive agreement for Almirall to market Sativex in Europe (excluding the UK). In the UK and Canada, Bayer HealthCare have been appointed as exclusive distributors.
In clinical trials, Sativex has generally been well tolerated.
Compare dronabinol (marketed as Marinol), a synthetic version of THC.
Scotoma

# Overview
A scotoma (Greek: darkness; plural: "scotomas" or "scotomata") is an area or island of loss or impairment of visual acuity surrounded by a field of normal or relatively well-preserved vision.
Every normal mammalian eye has a scotoma in its field of vision, usually termed its blind spot.  The presence of this normal scotoma does not intrude into consciousness because it is very small, but it can be demonstrated to oneself by the simplest of clinical methods (such as the one in the blind spot article).

# Presentation
Symptom-producing or pathological scotomata may be due to a wide range of disease processes, affecting either the retina (in particular its most sensitive portion, the macula) or the optic nerve itself.  A pathological scotoma may involve any part of the visual field and may be of any shape or size.  A scotoma may include and enlarge the normal blind spot.  Even a small scotoma that happens to affect central or macular vision will produce a severe visual handicap, whereas a large scotoma in the more peripheral part of a visual field may go unnoticed by the bearer due to the normal reduced visual resolution in the peripheral visual field.

# Causes
Common causes of scotomata include demyelinating disease such as multiple sclerosis  (retrobulbar neuritis), toxic substances such as methyl alcohol, ethambutol and quinine, nutritional deficiencies, and vascular blockages either in the retina or in the optic nerve.  Scintillating scotoma is a common visual aura in migraine. Less common, but important because sometimes reversible or curable by surgery, are scotomata due to tumors such as those arising from the pituitary gland, which may compress the optic nerve or interfere with its blood supply.
Rarely, scotomata are bilateral.  One important variety of bilateral scotoma may occur when a pituitary tumour begins to compress the optic chiasm (as distinct from a single optic nerve) and produces a bi-temporal hemicentral scotomatous hemianopia.  This type of visual field defect tends to be very eloquent symptom-wise but often evades early objective diagnosis, as it is more difficult to detect by cursory clinical examination than the classical or text-book bi-temporal peripheral hemianopia and may even elude sophisticated electronic modes of visual field assessment.
In a pregant woman, scotomata can present as a symptom of severe preeclampsia, a form of pregnancy-induced hypertension.
Scrapie
Scrapie is a fatal, degenerative disease that affects the nervous systems of sheep and goats.  It is one of several transmissible spongiform encephalopathies (TSEs), which are related to bovine spongiform encephalopathy (BSE or "mad cow disease") and chronic wasting disease of deer. Like other spongiform encephalopathies, scrapie is believed to be caused by a prion. Scrapie has been known since the 18th century (1732) and does not appear to be transmissible to humans.
The name scrapie is derived from one of the symptoms of the condition, wherein affected animals will compulsively scrape off their fleece against rocks, trees or fences.  The disease apparently causes an itching sensation in the animals.  Other symptoms include excessive lip-smacking, strange gaits, and convulsive collapse.
Scrapie is infectious and transmissible among similar animals, and so one of the most common ways to contain scrapie (since it is incurable) is to quarantine and destroy those affected. However, scrapie tends to persist in flocks and can also arise apparently spontaneously in flocks that have not previously had cases of the disease. The mechanism of transmission between animals and other aspects of the biology of the disease are only poorly understood and these are active areas of research. Recent studies suggest that prions may be spread through urine and persist in the environment for decades.
In the United Kingdom, the government has put in place a National Scrapie Plan, which encourages breeding from sheep that are genetically more resistant to scrapie. It is intended that this will eventually reduce the incidence of the disease in the UK sheep population. Scrapie occurs in Europe and North America, but to date Australia and New Zealand (both major sheep-producing countries) are scrapie-free.
A test is now available which is performed by sampling a small amount of lymphatic tissue from the third eyelid.
Out of fear of BSE, many European countries banned some traditional sheep or goat products made without removing the spinal cord such as smalahove and smokie.
Seafood

# Overview
Seafood is any sea animal or seaweed that is served as food or is suitable for eating, particularly seawater animals, such as fish and shellfish (including mollusks and crustaceans). By extension, in North America although not generally in the United Kingdom, the term seafood is also applied to similar animals from fresh water and all edible aquatic animals are collectively referred to as seafood.
Edible seaweeds are rarely considered seafood, even though they come from seawater and are widely eaten around the world.  See the category of sea vegetables.
The harvesting of seafood is known as fishing and the cultivation of seafood is known as aquaculture, mariculture, or simply fish farming.
Seafood is a source of protein in many diets around the world.

# Predicted collapse
Research into population trends of various species of seafood is pointing to a global collapse of seafood species by 2048. Such a collapse would occur due to pollution and overfishing, threatening oceanic ecosystems,  according to some researchers.
A major international scientific study released in November 2006 in the journal Science found that about one-third of all fishing stocks worldwide have collapsed (with a collapse being defined as a decline to less than 10% of their maximum observed abundance), and that if current trends continue all fish stocks worldwide will collapse within fifty years.
The FAO State of World Fisheries and Aquaculture 2004 report estimates that in 2003, of the main fish stocks or groups of resources for which assessment information is available, "approximately one-quarter were overexploited, depleted or recovering from depletion (16%, 7% and 1% respectively) and needed rebuilding."
Advocacy organizations such as the National Fisheries Institute, however, disagree with such findings and assert that currently observed declines in fish population are due to natural fluctuations and that enhanced technologies will eventually alleviate whatever impact humanity is having on oceanic life.

# Dishes
- Bouillabaisse
- Fried calamari
- Ceviche
- Cioppino
- Clam chowder
- Shrimp cocktail
- Sashimi
- Sushi
Sen-Sen
Sen-sen, marketed as a "breath perfume" is a type of breath freshener. In the early years of the twentieth century, before the health risks of tobacco were scientifically determined, Sen-sen was a commercial product that would "cover up" the smell of tobacco on one's breath and clothes at a time when there were just moral and personal reasons for disapproving of tobacco. Adolescent boys would use it, for instance, to attempt to hide from their parents the fact that they had been smoking. Thus did "Sen-sen" enter the list of moral faults caused by pocket-billiards in the song "Ya Got Trouble" in the musical comedy The Music Man.  The product is mentioned in the Billy Joel song "Keeping the Faith." (I took a fresh pack of Luckies
And a mint called Sen-Sen.)
Sen-sen is mentioned in the book "Their Eyes Were Watching God" and referred to as also covering not only tobacco breath, but 'liquor breath'.  It also was mentioned in the book "A Tree Grows in Brooklyn" as Hildy O'Dair had used it.
In Europe, there was a similar product oriented towards female smokers, called tabac blond.

# External link
- Sen-Sen, official website.
de:Sen-Sen
Seredyn
Seredyn, produced  by BioNeurix Corporation, is marketed as a natural remedy used to treat anxiety, stress and insomnia. Utilizing 3 active ingredients, including two plant extracts and an amino acid, the makers claim to be able to reduce the symptoms of chronic anxiety, stress and fatigue. The product is a counterpart to another produced by the same company, Amoryn, which is aimed more towards patients who are seeking relief from depression, as well as anxiety. The makers claim it is safe to use both remedies at the same time. Because both Seredyn and Amoryn are natural remedies derived from plants, neither products are FDA approved, and are available without a prescription. 
There is an Auto Ship Order system, but you cannot make any cancellation once you made.

# Active ingredients
- L-Theanine: An amino acid found in green tea.
- Passion flower: A plant extract, Passiflora incarnata, claimed to reduce symptoms of anxiety.
- Valerian: A plant extract, Valeriana officinalis, used as a sedative and relaxant.

# Possible side effects
Due to the possible sedative effects of this agent, patients just starting a regiment of Seredyn should be careful about operating a vehicle or operating machinery until one is familiar with the possible side effects, which include:
- Drowsiness
- Fatigue
- Stomach Upset
- Headache
- Increased sensitivity to sedative drugs
- Low blood pressure
Serovar
A serovar or serotype is a grouping of microorganisms or viruses based on their cell surface antigens. Serovars allow organisms to be classified at the sub-species level; an issue of particular importance in epidemiology.
Serovars may be established based on virulence factors, lipopolysaccharides in Gram-negative bacteria, presence of an exotoxin (pertussis toxin in Bordetella pertussis, for example), plasmids, phages, or other characteristics which differentiate two members of the same species. 
Salmonella, for example, has over 4400 serovars: Salmonella enterica serovar Typhimurium, S. enterica serovar Typhi, and S. enterica serovar Dublin, to name a few.
Vibrio cholerae, which causes cholera, has 139 serotypes, based on cell antigens. Only two of them produce an enterotoxin and are pathogens: 0:1 and 0:139.
Serotypes were discovered by the American microbiologist Rebecca Lancefield in 1933.