List of epidemics
This article is a list of major epidemics.

# Worldwide Pandemics
- 165-180: Antonine Plague, perhaps smallpox
- 541: the Plague of Justinian
- 1300s: the Black Death
- 1501-1587: typhus
- 1732-1733: influenza
- 1775-1776: influenza
- 1816-1826: cholera
- 1829-1851: cholera
- 1847-1848: influenza
- 1852-1860: cholera
- 1855-1950s: bubonic plague: Third Pandemic
- 1857-1859: influenza
- 1863-1875: cholera
- 1889-1892: influenza
- 1899-1923: cholera
- 1918-1920: avian flu: Spanish flu: more people were hospitalized in World War I from this epidemic than wounds. Estimates of the dead range from 20 to 40 million worldwide (WHO)
- 1960s: cholera called El Tor
- 1980s to present:  HIV

# Regional

## Asia
- 1957-1958: avian flu: Asian flu
- 1968-1969: avian flu: Hong Kong flu
- 1997: avian flu - China, Hong Kong
- 2002-2003: SARS

## Central and South America
- 1493: influenza - Hispaniola
- 1518: smallpox - Hispaniola
- 1520: smallpox - Mexico
- 1527-1530: smallpox - Peru
- 1530-1531: measles - Mexico, Peru
- 1546: typhus - Mexico, Peru
- 1558-1559: influenza - Mexico, Peru
- early 1600s: malaria
- 1648: yellow fever

## Europe
- 1347-1351: Black Death

## Egypt
- 1801: plague
- 1831: cholera
- 1834-1836: plague
- 1848, 1865, 1881: cholera
- 1902: cholera
- 1942-1944: falciparum malaria
- 1946: relapsing fever
- 1947: cholera

## North America
- 1657: measles - Boston, Massachusetts
- 1687: measles - Boston, Massachusetts
- 1690: yellow fever - New York, New York
- 1713: measles - Boston, Massachusetts
- 1721-1722:smallpox - Boston, Massachusetts
- 1729: measles - Boston, Massachusetts
- 1738: smallpox - South Carolina
- 1739-1740: measles - Boston, Massachusetts
- 1747: measles - Connecticut, New York, Pennsylvania, South Carolina
- 1759: measles - North America
- 1761: influenza - North America and West Indies
- 1772: measles - North America
- 1775: unknown cause - North America, particularly in the northeast
- 1783: bilious disorder - Dover, Delaware
- 1788: measles - Philadelphia, Pennsylvania and New York
- 1793: influenza and "putrid fever" - Vermont
- 1793: influenza - Virginia
- 1793: yellow fever - Philadelphia, Pennsylvania
- 1793: unknown - Harrisburg, Pennsylvania
- 1793: unknown - Middletown, Pennsylvania
- 1794: yellow fever - Philadelphia, Pennsylvania
- 1796-1797: yellow fever - Philadelphia, Pennsylvania
- 1798: yellow fever - Philadelphia, Pennsylvania
- 1803: yellow fever - New York
- 1820-1823: fever - United States spreading from the Schuylkill River
- 1831-1832: Asiatic cholera - United States (brought by English immigrants)
- 1832: cholera - New York City and other major cities
- 1833: cholera - Columbus, Ohio
- 1834: cholera - New York City
- 1837: typhus - Philadelphia
- 1841: yellow fever - United States (especially severe in the South)
- 1847: yellow fever New Orleans
- 1848-1849: cholera - North America
- 1849: cholera New York
- 1850: yellow fever - United States
- 1850-1851: influenza - North America
- 1851: cholera Coles County, Illinois, The Great Plains, and Missouri
- 1852: yellow fever - United States (New Orleans-8,000 die in summer)
- 1855: yellow fever - United States
- 1860-1861: smallpox - Pennsylvania
- 1865-1873: smallpox - Philadelphia, New York City, Boston, New Orleans
- 1865-1873: cholera - Baltimore, Maryland, Memphis, Washington, DC
- 1865-1873: recurring epidemics of typhus, typhoid, scarlet fever, and yellow fever
- 1873-1875: influenza - North America and Europe
- 1876: smallpox - Deadwood, South Dakota
- 1878: yellow fever - Memphis, New Orleans
- 1885: typhoid - Plymouth, Pennsylvania
- 1886: yellow fever - Jacksonville, Florida
- 1918-1920: Spanish flu - Fort Riley, Kansas