Colocynth
The colocynth, also known as bitter apple, bitter cucumber, egusi, or vine of Sodom, is a viny plant native to the Mediterranean Basin and Asia, especially Turkey (especially in regions such as Izmir), Nubia, and Trieste. It originally bore the scientific name Colocynthis citrullus, but is now classified as Citrullus colocynthis.
Its fruit, which is lemon-sized, yellowish, green-mottled, spongy, and extremely bitter, is a powerful hepatic stimulant and hydragogue cathartic. It is used as a strong laxative. In overdoses, the fruit can cause violent, sharp pains in the bowels, with dangerous inflammation. Given that the colocynth grows wild in Israel, these symptoms would be consistent with the "wild gourd" mentioned in II Kings 4:39-40. It is seldom used alone, but in combination with other cathartics has been a standard remedy. It has been used alone in obstinate edema, amenorrhea, and in cerebral derangements. A normal dose of fluid extracted from the fruit pulp is 2 to 5 minims, and for the powdered extract, 1 to 2 grains.
Its seed, which is edible but similarly bitter, nutty-flavored, and rich in fat and protein, is eaten whole or used as an oilseed. The oil content of the seeds is 17-19% (w/w), consisting of 67-73% linoleic acid, 10-16% oleic acid, 5-8% stearic acid, and 9-12% palmitic acid. It is estimated that the oil yield is approximately 400 L/hectare.
The characteristic small seed of the colocynth have been found in several early archeological sites in northern Africa and the Near East, specifically at Neolithic Armant, Nagada (dated 3650-2850 BC), and Hierakonopolis (3500-3300 BC) in Egypt; at sites dating from 3800 BC to Roman times in Libya; and the pre-pottery Neolithic levels of the Nahal Hemar Caves in Israel. Zohary and Hopf speculate that "these finds indicate that the wild colocynth was very probably used by humans prior to its domestication."
Desert Bedouins are said to make a type of bread from the ground seeds. There is some confusion between this species and the closely-related watermelon, whose seeds may be used in much the same way. In particular the name "egusi" may refer to either or both plants (or more generically to other cucurbits) in their capacity as seed crops, or to a soup made from these seeds and popular in West Africa.

# Pre-modern medical uses
In pre-modern medicine it was an ingredient in the electuary called confectio hamech, or diacatholicon, and most other laxative pills; and in such cases as required purging, it was very successful. It is one of the most violent purgative drugs known; insomuch that it excoriates the passages to such a degree as to sometimes draw blood, and induce a so-called "superpurgation". Sometimes, it was taken boiled in water, or beer, in obstruction of the menses, which was considered successful in strong constitutions. Some women used it in the same manner, in the beginning of pregnancy, to cause an abortion, which often occurred due to the violence of its operation. Its usage for this purpose is documented in ancient times; for example, the following recipe was found in the Ebers medical papyrus in Egypt, dated to about 1550 BCE:
The powder of colocynth was sometimes used externally, with aloes, etc, in unguents, plasters, etc, with remarkable success against parasitic worms; and some, for the same purpose, recommended that the pulp be used as an enema. In iliac passion, enemas of colocynth were used effectively where most other pre-modern medicines had failed.
Troches, or lozenges, made of colocynth were called "troches of alhandal". They were prepared by cutting the colocynth to a small size, and reducing it to a fine powder in a mortar, rubbed with oil of sweet almonds; adding gum tragacanth, and mastic afterwards.
Remedies for counteracting colocynth have included emetics, such as zinc sulfate, and apomorphine, if caught early; later, demulcents and opiates, with stimulants to combat collapse.