Persius/hicric huggingface dataset:
EMR1
EGF-like module-containing mucin-like hormone receptor-like 1 also known as F4/80 is a protein encoded by the ADGRE1 gene. EMR1 is a member of the adhesion GPCR family.
Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
EMR1 expression in human is restricted to eosinophils and is a specific marker for these cells. The murine homolog of EMR1, F4/80, is a well-known and widely used marker of murine macrophage populations. The N-terminal fragment (NTF) of EMR1 contains 4-6 Epidermal Growth Factor-like (EGF-like) domains in human and 4-7 EGF-like domains in the mouse.

# Function
Utilizing F4/80 knockout mice, Lin et al. showed that F4/80 is not necessary for the development of tissue macrophages but is required for the induction of efferent CD8+ regulatory T cells needed for peripheral tolerance.

# Clinical significance
Legrand et al. demonstrated that EMR1 can serve as a therapeutic target for depletion of these cells in eosinophilic disorders by using afucosylated antibodies.
EMR3
EGF-like module-containing mucin-like hormone receptor-like 3 is a protein encoded by the ADGRE3 gene. EMR3 is a member of the adhesion GPCR family.
Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
EMR3 expression is restricted to monocytes/macrophages, myeloid dendritic cells, and mature granulocytes in human. Transcription of the EMR3 gene results in two alternative spliced forms: a surface protein with extracellular, 7TM, and intracellular domains as well as a truncated soluble form of only the extracellular domain. Mice, next to Emr2, lack the Emr3 gene.

# Function
The protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.

# Ligands
A potential ligand of EMR3 likely is expressed on human macrophage and activated neutrophils.
EMSY
EMSY is a protein that in humans is encoded by the EMSY gene.

# Clinical significance
EMSY has been shown to associate with atopy and susceptibility to poly-sensitisation.

# Interactions
EMSY has been shown to interact with ZMYND11, BRCA2 and CBX1.
EMX2
Homeobox protein Emx2 is a protein that in humans is encoded by the EMX2 gene.

# Function
The homeodomain transcription factor EMX2 is critical for central nervous system and urogenital development. EMX1 (MIM 600034) and EMX2 are related to the 'empty spiracles' gene expressed in the developing Drosophila head..
The EMX2 gene encodes for a transcription factor that is a homolog to Drosophila melanogaster empty spiracles gene. The empty spiracles gene is needed for the proper head development/formation as well as the development of posterior spiracles in Drosophila melanogaster.
In humans, EMX2 shows high expression in the dorsal telencephalon, olfactory neuroepithelium, as well as the urogenetial system. In the developing uroepithelium, EMX2 is negatively regulated by HOXA10. EMX2 has been associated with Schizencephaly, a disease where there are large parts of the brain hemispheres absent and that are replaced with cerebrospinal fluid, clinical observations can include seizures, blindness, and inability to walk/speak. EMX2 has also been shown to have an important role in tumorigenesis. One study found that the expression of EMX2 is significantly decreased in tissues and cells with colorectal cancer. It is suspected that EMX2 could be used as a treatment of colorectal cancer.
ENAM
Enamelin is a protein that in humans is encoded by the ENAM gene.
Dental enamel is a highly mineralized tissue with 85% of its volume occupied by unusually large, highly organized, hydroxyapatite crystals. This highly organized and unusual structure is thought to be rigorously controlled in ameloblasts through the interaction of a number of organic matrix molecules that include enamelin, amelogenin (AMELX; MIM 300391), ameloblastin (AMBN; MIM 601259), tuftelin (TUFT1; MIM 600087), dentine sialophosphoprotein (DSPP; MIM 125485), and a variety of enzymes. Enamelin is the largest protein in the enamel matrix of developing teeth and comprises approximately 5% of total enamel matrix protein.
Mutations in the ENAM gene can give rise to autosomal dominant Amelogenesis imperfecta, indicating a role in Amelogenesis.
ENC1
Ectoderm-neural cortex protein 1 is a protein that in humans is encoded by the ENC1 gene.

# Function
DNA damage and/or hyperproliferative signals activate wildtype p53 tumor suppressor protein (TP53; MIM 191170), inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50% of all tumors. Polyak et al. (1997) used serial analysis of gene expression (SAGE) to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53. Of 7,202 transcripts identified, only 14 were expressed at levels more than 10-fold higher in p53-expressing cells than in control cells. Polyak et al. (1997) termed these genes 'p53-induced genes,' or PIGs, several of which were predicted to encode redox-controlling proteins. They noted that reactive oxygen species (ROS) are potent inducers of apoptosis. Flow cytometric analysis showed that p53 expression induces ROS production, which increases as apoptosis progresses under some conditions. The authors stated that the PIG10 gene, also called ENC1, encodes an actin-binding protein.

# Interactions
ENC1 has been shown to interact with Retinoblastoma protein.

# Model organisms
Model organisms have been used in the study of ENC1 function. A conditional knockout mouse line called Enc1tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed:  - In-depth immunological phenotyping
ENTJ
ENTJ (Extroverted iNtuitive Thinking Judging) is one of the sixteen personality types from personality type systems based on C.G. Jung, of which the best-known is the Myers-Briggs Type Indicator (MBTI). Under 2 percent of the population rank as ENTJ.
Referring to Keirsey, ENTJs belong to the temperament of the Rationals and are called Fieldmarshals.
ENTJ is sometimes considered to be the ideal type in business - for example MBA students who take the MBTI are expected to test as ENTJ. One could argue however that ESTJ are more apt at the routine of working one's way up in a large business organization than the visionary and original ENTJ.

# MBTI cognitive functions
The attributes of each personality form a hierarchy.  This represents the person's "default" pattern of behavior in their day to day life. The Dominant is the personality type's preferred role, the task they feel most comfortable with.  The auxiliary function is the role they feel the next most comfortable with.  It serves to support and expand on the dominant function.  One of these first two will always be an information gathering function (sensing or intuition) and the other will be a decision making function(thinking or feeling) in some order. The tertiary function is less developed than the Dominant and Auxiliary functions, but develops as the person matures and provides roundness of ability.  The inferior function is the personality types Achille's heel. This is the function they are least comfortable with. Like the tertiary function, this function strengthens with maturity.
- Dominant Extroverted Thinking (Te)
- Auxiliary Introverted Intuition (Ni)
- Tertiary Extroverted Sensing (Se)
- inferior Introverted Feeling (Fi)

# Famous People
U.S. Presidents: 
Franklin D. Roosevelt 
Richard M. Nixon
- Benny Goodman, "Big Band" leader
- General Norman Schwarzkopf
- Harrison Ford
- Steve Martin
- Whoopi Goldberg
- Sigourney Weaver
- Margaret Thatcher
- Al Gore (U.S. Vice President, 1993-2001)
- Lamar Alexander (former governor, U.S. Secretary of Education)
- Les Aspen, former U.S. Secretary of Defense
- Candace Bergen (Murphy Brown)
- Dave Letterman
- Newt Gingrich
- Patrick Stewart (STNG: Jean Luc Picard)
- Robert James Waller (author: The Bridges of Madison County)
- Jim Carrey (Ace Ventura: Pet Detective, The Mask)
- Steve Jobs
- Hitler
- Penn Jillette
- Bill Gates
- Quentin Tarantino
- Jack London
EPN1
Epsin-1 is a protein that in humans is encoded by the EPN1 gene.
EPN1 is an endocytic accessory protein that interacts with EPS15 (MIM 600051), the alpha subunit of the clathrin adaptor AP2 (AP2A1; MIM 601026), and clathrin (see MIM 118960), as well as with other accessory proteins for the endocytosis of clathrin-coated vesicles.

# Interactions
EPN1 has been shown to interact with REPS2, AP2A2 and EPS15.
EPRS
Bifunctional aminoacyl-tRNA synthetase is an enzyme that in humans is encoded by the EPRS gene.

# Gene
Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined.

# Function
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species.
Phosphorylation of EPRS is reported to be essential for the formation of GAIT (Gamma-interferon Activated Inhibitor of Translation) complex that regulates the translation of multiple genes in monocytes and macrophages.

# Interactions
EPRS has been shown to interact with POU2F1, Heat shock protein 90kDa alpha (cytosolic), member A1 and IARS.
EPS8
Epidermal growth factor receptor kinase substrate 8 is an enzyme that in humans is encoded by the EPS8 gene.

# Function
This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

# Clinical significance
Mutations in EPS8 cause                 congenital deafness            .Behlouli A, Bonnet C, Abdi S, Bouaita A, Lelli A, Hardelin JP, Schietroma C, Rous Y, Louha M, Cheknane A, Lebdi H, Boudjelida K, Makrelouf M, Zenati A, Petit C (2014). "EPS8, encoding an actin-binding protein of cochlear hair cell stereocilia, is a new causal gene for autosomal recessive profound deafness". Orphanet Journal of Rare Diseases. 9 (1): 55. doi:10.1186/1750-1172-9-55. PMC 4022326. PMID 24741995..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"\"""\"""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{display:none;font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}

# Interactions
EPS8 has been shown to interact with:
- ABI1,
- BAIAP2,
- DVL1,
- SHB,
- SHC1
- SOS1,  and
- Src.
ERN1
The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1   (IRE1) is an enzyme that in humans is encoded by the ERN1 gene.

# Function
The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals (mainly the unfolded protein response). Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

# Signaling
IRE1 possesses two functional enzymatic domains, an endonuclease and a trans-autophosphorylation kinase domain. Upon activation, IRE1 oligomerizes and carries out an unconventional RNA splicing activity, removing an intron from the X-box binding protein 1 (XBP1) mRNA, and allowing it to become translated into a functional transcription factor, XBP1s. XBP1s upregulates ER chaperones and endoplasmic reticulum associated degradation (ERAD) genes that facilitate recovery from ER stress.

# Interactions
ERN1 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1.

# Inhibitors
Two types of inhibitors exist targeting either the catalytic core of the RNase domain or the ATP-binding pocket of the kinase domain.

## RNase domain inhibitors
Salicylaldehydes (3-methoxy-6-bromosalicylaldehyde, 48C, MKC-3946, STF-083010, toyocamycin.

## ATP-binding pocket
Sunitinib and APY29 inhibit the ATP-binding pocket but allosterically activate the IRE1 RNase domain.
Compound 3 prevents kinase activity, oligomerization and RNase activity.
ESFJ
ESFJ (Extroverted Sensing Feeling Judging) is one of the sixteen personality types from the Myers-Briggs Type Indicator (MBTI), and the Keirsey Temperament Sorter.
Referring to Keirsey, ESFJs belong to the temperament of the Guardians and are called Providers.
ESFJ are the best hosts/hostesses, they love to organize social events and they will be very attentive to the well being of the guests. ESFJ are very sympathetic to the feelings of others. They also are very good at remembering names after only one introduction to the person. When an ESFJ admires something, they are apt to put it in a high place and when they dislike something, they put it down hard. ESFJ do not accept criticism, even when it is constructive. The reason is that they take it emotionally (like most things) and equate criticism with rejection. Likewise, they will rarely express a disagreement with someone, preferring to avoid sensitive subjects or pretend to agree. ESFJ are usually very popular. They can do well in commercial professions.

# MBTI cognitive functions
The attributes of each personality form a hierarchy.  This represents the person's "default" pattern of behavior in their day to day life. The Dominant is the personality type's preferred role, the task they feel most comfortable with.  The auxiliary function is the role they feel the next most comfortable with.  It serves to support and expand on the dominant function.  One of these first two will always be an information gathering function (sensing or intuition) and the other will be a decision making function(thinking or feeling) in some order. The tertiary function is less developed than the Dominant and Auxiliary functions, but develops as the person matures and provides roundness of ability.  The inferior function is the personality types Achille's heel. This is the function they are least comfortable with. Like the tertiary function, this function strengthens with maturity.
- Dominant Extroverted Feeling (Fe)
- Auxiliary Introverted Sensing (Si)
- Tertiary Extroverted Intuition (Ni)
- inferior Introverted Thinking (Ti)
ESM1
Endothelial cell-specific molecule 1 is a protein that in humans is encoded by the ESM1 gene.
This gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals.
The ESM-1 gene product is also called endocan since 2001, when it was characterized as a dermatan sulfate proteoglycan by Bechard et al.  Recently, endocan / ESM-1 has been described as a specific biomarker of tip cells during neoangiogenesis by independent teams. Endocan expression has been shown to be increase in presence of pro-angiogenic growth factors such as vascular endothelial growth factor (VEGF) or fibroblast growth factor 2 (FGF-2).   In hypervascularized cancers, overexpression of endocan has been detected by immunohistochemistry using monoclonal antibodies against endocan / ESM-1.
ESTJ
ESTJ (Extroverted Sensing Thinking Judging) is one of the sixteen personality types from the Myers-Briggs Type Indicator (MBTI), and the Keirsey Temperament Sorter.
Referring to Keirsey, ESTJs belong to the temperament of the guardians and are called "Supervisors".

# Myers-Briggs Characteristics
ESTJs are practical, realistic, and matter-of-fact, with a natural head for business or mechanics. Though they are not interested in subjects they see no use for, they can apply themselves when necessary. They like to organize and run activities.  ESTJs make good administrators, especially if they remember to consider others' feelings and points of view, which they often miss.

# Keirsey Characteristics
According to Keirsey, ESTJs, or "Supervisor Guardians", are civic-minded individuals who dedicate themselves to maintaining the institutions behind a smooth-running society.  They are defenders of the status quo and strong believers in rules and procedures.  Outgoing, they don't hesitate to communicate their opinions and expectations to others.

# MBTI cognitive functions
The attributes of each personality form a hierarchy.  This represents the person's "default" pattern of behavior in their day to day life. The Dominant is the personality type's preferred role, the task they feel most comfortable with.  The auxiliary function is the role they feel the next most comfortable with.  It serves to support and expand on the dominant function.  One of these first two will always be an information gathering function (sensing or intuition) and the other will be a decision making function(thinking or feeling) in some order. The tertiary function is less developed than the Dominant and Auxiliary functions, but develops as the person matures and provides roundness of ability.  The inferior function is the personality types Achille's heel. This is the function they are least comfortable with. Like the tertiary function, this function strengthens with maturity.
- Dominant Extroverted Thinking
- Auxiliary Introverted Sensing
- Tertiary Extroverted iNtuition
- inferior Introverted Feeling
ESTP
ESTP (Extroverted Sensing Thinking Perceiving) is one of the sixteen personality types from the Myers-Briggs Type Indicator (MBTI), and the Keirsey Temperament Sorter.
Referring to Keirsey, ESTPs belong to the Artisan temperament and are called "Promoters".

# Myers-Briggs Characteristics
According to Myers-Briggs, ESTPs are hands-on learners who live in the moment, seeking the best in life, wanting to share it with their friends.  The ESTP is open to situations, able to improvise to bring about desired results.  They are active people who want to solve their problems rather than simply discuss them.

# Keirsey Characteristics
According to Keirsey, ESTPs, or "Promoter Artisans", are the most adept among the types at manipulating other people.  The ESTP knows everyone who matters and everything there is to do.  They like to indulge themselves in the finer things in life and to bring other people with them.  Their goal in life is to sell themselves and their ideas to others.  Dramatic and debonair, they are gifted at earning others' confidence.

# MBTI cognitive functions
The attributes of each personality form a hierarchy.  This represents the person's "default" pattern of behavior in their day to day life. The Dominant is the personality type's preferred role, the task they feel most comfortable with.  The auxiliary function is the role they feel the next most comfortable with.  It serves to support and expand on the dominant function.  One of these first two will always be an information gathering function (sensing or intuition) and the other will be a decision making function(thinking or feeling) in some order. The tertiary function is less developed than the Dominant and Auxiliary functions, but develops as the person matures and provides roundness of ability.  The inferior function is the personality types Achille's heel. This is the function they are least comfortable with. Like the tertiary function, this function strengthens with maturity.
- Dominant Extroverted Sensing
- Auxiliary Introverted Thinking
- Tertiary Extroverted Feeling
- inferior Introverted iNtuition
Enol
Enols (also known as alkenols) are alkenes with a hydroxyl group affixed to one of the carbon atoms composing the double bond. Enols and carbonyl compounds (such as ketones and aldehydes) are in fact isomers; this is called keto-enol tautomerism:
The enol form is shown on the left. It is usually unstable, does not survive long, and changes into the keto (ketone) form shown on the right. This is because oxygen is more electronegative than carbon and thus forms stronger multiple bonds. Hence, a carbon-oxygen (carbonyl) double bond is more than twice as strong as a carbon-oxygen single bond, but a carbon-carbon double bond is weaker than two carbon-carbon single bonds.
Only in 1,3-dicarbonyl and 1,3,5-tricarbonyl compounds does the (mono)enol form predominate. This is because the resonance and intermolecular hydrogen bonding that occurs in the enol form is not possible in the keto form. Thus, at equilibrium, over 99% of propanedial (OHCCH2CHO) molecules exist as the monoenol. The percentage is lower for 1,3-aldehyde ketones and diketones. Enols (and enolates) are important intermediates in many organic reactions.
The words enol and alkenol are portmanteaux of the words alkene (or just -ene, the suffix given to alkenes) and alcohol (which represents the enol's hydroxyl group).

# Enolate ion
When the hydroxyl group (OH) in an enol loses a hydrogen ion (H+), a negative enolate ion is formed as shown here:
Enolates can exist in quantitative amounts in strictly Brnsted acid free conditions, since they are generally very basic.
1,3-dicarbonyl and 1,3,5-tricarbonyl compounds are quite acidic because of the strong resonance stabilization created when one of the hydrogens is removed (from either the keto or enol forms). The resonance of the enol is exactly analogous to that used to explain the acidity of phenols and consists of the delocalisation of the enolate ion's negative charge to the alpha carbon. These enolate ions are very valuable in synthesis of complicated alcohols and carbonyl compounds (aldol additions). The synthetic value is due to the nucleophilicity of -carbon of enolate group.
In ketones (a type of carbonyl) with acidic -hydrogens on either side of the carbonyl carbon, selectivity of deprotonation may be achieved to generate the enolate directly from the ketone. At low temperatures (-78C, i.e. dry ice bath), in aprotic solvents, and with bulky non-equilibrating bases (e.g. LDA) the "kinetic" proton may be removed. The "kinetic" proton is the one which is sterically most accessible. Under thermodynamic conditions (warmer temperatures, weak base, and protic solvent) equilibrium is established between the ketone and the two possible enolates, the enolate favoured is termed the "thermodynamic" enolate and is favoured because of its lower energy level than the other possible enolate. Thus, by choosing the "correct" conditions to generate an enolate, one can increase the yield of the desired product while minimizing formation of undesired products.

# Natural occurrences
Vitamin C is a sugar acid containg an enol bond. It can lose a proton as pictured, which makes it an acid:
de:Enole
he:
hu:Enol
mk:
fi:Enoli
sv:Enol