Persius/hicric huggingface dataset:
Recommendations from the Brazilian Society of Nephrology for approaching Covid-19 Diagnostic Testing in Dialysis Units



# Abstract
The Covid-19 pandemic brought several challenges to the healthcare system: diagnosis, treatment and measures to prevent the spread of the disease. With the greater availability and variety of diagnostic tests, it is essential to properly interpret them. This paper intends to help dialysis units concerning the use of clinical criteria and diagnostic tests for decision making regarding the discontinuation of isolation of patients with suspected or confirmed Covid-19, as well as the return to work activities for employees with suspected or confirmed Covid-19.

## Keywords:
Covid A estrategia baseada em criterios clinicos pode ser utilizada nos casos com sintomatologia leve, baixa suspeicao de Covid-19 ou se o teste laboratorial (sorologia ou RT-PCR) nao estiver disponivel 1 .
Antibiotic prophylaxis is not indicated prior to dental procedures for prevention of periprosthetic joint infections


[table] Table 4: Bias assessment of the studies included, according to the GRADE method [/table]
[table] Table 5: An overview of international recommendations AAOS: American Academy of Orthopaedic Surgeons; ADA: American Dental Association; AFSSAPS/ANSM: French health authorities; BASC: British Society for Antimicrobial Chemotherapy; BOA: British Orthopaedic Association; DE: dentists; IN: infectiologists; NZDA: New Zealand Dental Association; MI: microbiologists; OMFS: oral and maxillofacial surgeons; OS: orthopedic surgeons; SGINF: Swiss Society for Infectious Diseases. [/table]
Saudi Oncology Society clinical management guideline series

King Fahad Specialist Hospital, Dammam, and the Department of Oncology (Al-Shehri)
11211. 2014
MBBSbazarbashi@gmail.com 
MBChB, FRCRMDPhDMBChB, FRCPCMDMBChBMBBS, FRCSCPhDMBBCh, FRCP (UK)MBBSMDMD, FRCPCKing Fahad Specialist Hospital, Dammam, and the Department of Oncology (Al-Shehri)
Princess Nora Oncology Center, King Abdulaziz Medical City
Jeddah, Kingdom of Saudi Arabia; Riyadh335411442393511211. 2014Received 15th July 2014. Accepted 13th October 2014.Address correspondence and reprint request to: Dr. Shouki N. 1538
C olorectal cancer ranked first in incidence among Saudi males and third among Saudi females for the last several years according to Saudi Cancer Registry data.A total of 1033 cases accounting for 10.4% of all newly diagnosed cases were reported in 2010.The overall age standardized rate (ASR) was 9.6/100,000 with ASR of 9.9/100,000 for males and 9.2/100,000 for females. The median age at diagnosis was 60 years for males (range 2-100 years) and 55 years for females (range 13-100 years).A committee of experts in the medical and surgical treatment of colorectal cancer was established under the supervision of the Saudi Oncology Society (SOS). The evidence adopted in these guidelines is rated at 3 levels: 1) Evidence level-1 (EL-1) (highest level) evidence from phase III randomized trials or meta-analyses; 2-EL-2 (intermediate-level) evidence from good phase II trials or phase III trials with limitations; and 3-EL-3 (low-level) from retrospective or observational data and/or expert opinion. This easy-to-follow grading system is convenient for the reader and allows accurate assessment of the applicability of the guideline in individual patients.Ultimately, it was agreed that all colorectal cancer cases are preferably seen or discussed in a multidisciplinary form In case of violation of any of the above, surgery should be offered. If surgery is not an option, adjuvant chemoradiotherapy should be offered (EL-3) 4.2.3. All clinically T3-4 or N positive lesions will receive pre-operative concurrent chemoradiotherapy. The irradiation will consist of 5040 cGy in 28 fractions and the chemotherapy will consist of capecitabine or infusional 5-Fluorouracil 16 (EL-1). Surgery will be performed 6-8 weeks after the end of radiation therapy. Short course radiation 2500 cGy in 5 fractions with surgical resection in one week can be considered if sphincter saving is not an option 17 (EL-1) [bib_ref] Capecitabine as adjuvant treatment for stage III colon cancer, Twelves [/bib_ref]
7th Brazilian Guideline of Arterial Hypertension: Chapter 3 - Clinical and Complementary Assessment



## Basic laboratory investigation, assessment of subclinical and clinical target-organ damage
Complementary assessment is aimed at detecting subclinical or clinical TOD to better stratify CV risk. To stratify global CV risk, the classical RF (Chart 3), as well as Abdominal or thoracic murmurs (renovascular, coarctation of the aorta, disease of the aorta or its branches) Decreased femoral pulses (coarctation of the aorta, disease of the aorta or its branches)

## Difference of bp between arms (coarctation of the aorta and subclavian stenosis)
*For further information, see Chapter 12.

## Chart 3 -additional cardiovascular risk factors
Age (men > 55 years, women > 65 years)

## Smoking habit
Dyslipidemias: triglycerides > 150 mg/dL; LDL-C > 100 mg/dL; HDL-C < 40 mg/dL DM Family history of premature CVD: men < 55 years, women < 65 years the new ones identified, should be considered, although they have not been incorporated to the clinical scores of risk stratification. [bib_ref] Task Force Members. 2013 ESH/ESC guidelines for the management of arterial hypertension:..., Mancia [/bib_ref] [bib_ref] General cardiovascular risk profile for use in primary care: the Framingham Heart..., Sr [/bib_ref] Of the new RF, the following stand out: fasting glycemia between 100 mg/dL and 125 mg/dL, abnormal glycated hemoglobin (HbA1c), abdominal obesity (metabolic syndrome -MS), PP (SBP-DBP) > 65 mm Hg in the elderly, 5 history of preeclampsia, and family history of AH (for borderline hypertensive patients).
The laboratory assessment shown in Chart 4 should be part of the initial routine of all hypertensive patients. [bib_ref] Task Force Members. 2013 ESH/ESC guidelines for the management of arterial hypertension:..., Mancia [/bib_ref] The Cockroft-Gault formula is used to calculate creatinine clearance: 6 CrCl (mL/min) = [140 -age] x weight (kg) /serum creatinine (mg/dL) x 72 for men; for women, multiply the result by 0.85.
To estimate glomerular filtration rate (GFR) use the CKD-EPI equation. 

## Chart 5 -tests recommended for certain populations test/assessment recommended population and indication
Chest X ray Follow-up of patients with clinical suspicion of cardiac (GR: IIa; LE: C) and/or pulmonary impairment. Assessment of hypertensive individuals with aorta impairment when echocardiogram is not available. [bib_ref] The Chest Radiograph. A useful investigationin the evaluation of hypertensive patients, Rayner [/bib_ref] Echocardiogram More sensitive than ECG to diagnose LVH. Important in the assessment of the geometrical forms of left atrial hypertrophy and size, analysis of systolic and diastolic function. Consider LVH when left ventricular mass corrected for body surface is equal to or greater than 116 g/m 2 for men and 96 g/m 2 for women.Evidence of LVH on ECG or patients with clinical suspicion of HF (GR: I; LE: C). 
[fig] Chart 1 -: Objectives of clinical and laboratory assessment [/fig]
Headache in children

Headache in children
2013Headache in children
The Journal of Headache and Pain
1413201310.1186/1129-2377-14-S1-O3O R A L P R E S E N T A T I O N Cite this article as: Prabhakar: Headache in children.
One in 30 children who attend primary school have a headache problem which has an impact on the child and family. However, the problem is under recognised and under treated. In children, identifying a primary headache syndrome can be challengining. However, it can be achieved in a focussed consultation undertaking appropriate history and examination. The course aims to cover the common pitfalls and red flags in the diagnosis of primary headache disorders in childhood and treatment startegies.
Good Practice Recommendations from the Brazilian Society of Nephrology to Dialysis Units Concerning the Pandemic of the New Coronavirus (Covid-19)



## Resumo

# Abstract
Dialysis units are environments potentially prone to the spread of Covid-19. Patients cannot suspend treatment, and they often have comorbidities, which assigns them a higher risk and worse prognosis. The Brazilian Society of Nephrology prepared this document of good practices, whose technical recommendations deal with general measures that can be implemented to reduce the risk of transmission and prevent the spread of the disease in the unit.

## Keywords:
Covid In view of the epidemiological scenario and scientific advances, the SBN updated its recommendations, which are technical indications of good practices and must be adapted to the context and local reality, depending on adequate funding by public managers. The SBN has been striving in search of resources for renal replacement therapy in Brazil at this time of the pandemic.
There is still a scarcity of well-established data on the behavior of the virus and the natural history of the disease, 1 so any changes to this document may be necessary due to other scientific evidence that may appear. The proposed measures serve to inform and alert, preventing the spread of the virus and promoting preservation of care to the population with Chronic Kidney Disease undergoing dialysis treatment.
Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of intracerebral haemorrhage



## Classification of recommendations
Class I: there are confirmed evidence or unanimously agreement that the procedure or treatment given is effective.

## Emergency management of vascular abnormalities related ich recommendation
Surgery can be considered for the life-threatening secondary ICH. While surgically removing the hematoma, the treatment strategy may be weighed against the relative benefits and risks of saving the patient's life and eliminating the primary cause (Class IIa, Level of Evidence C).

## Section 3: surgical treatment for removal of haematoma
The surgical treatment of patients with ICH is shown in.

## Minimally invasive surgery

## Cardiac complications
Recommendation ECG and cardiac enzyme measurement is reasonable after cerebral haemorrhage to screen for cardiac complications (Class IIa, Level of Evidence C).

## Pulmonary infection and prevention recommendation
Swallowing test is recommended before oral feeding to decrease the risk of pneumonia (Class I, Level of Evidence B). In patients with ICH with atrial fibrillation, the effectiveness of using dabigatran, rivaroxaban or apixaban to reduce the risk of recurrence is uncertain (Class IIb, Level of Evidence C). 3. In patients with anticoagulant-related ICH, the best timing to restore oral anticoagulant therapy is uncertain (Class IIb, Level of Evidence B). 4. If necessary, patients with ICH may consider antiplatelet monotherapy (Class IIa, Level of Evidence B). 5. The monotherapy of aspirin can be restored within a few days from the onset of ICH, but the best timing is not clear (Class IIa, Level of Evidence B). 6. Whether the use of statins should be restricted in patients with ICH is uncertain (Class IIb, Level of Evidence C). 7. All patients with ICH should control blood pressure (Class I, Level of Evidence A). 8. Blood pressure control measures should be started immediately after ICH onset (Class I recommendation, Level of Evidence A). It is reasonable to target BP <130/80 mm Hg for long-term blood pressure control (Class IIa, Level of Evidence B). 9. Smoking cessation, avoiding excessive drinking and treatment of obstructive sleep apnoea might be reasonable to reduce the risk of ICH (Class IIb, Level of Evidence B).

## Screening and prevention of deep vein thrombosis (dvt)
Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders: executive summary and 2019 update of clinical management of cerebral venous sinus thrombosis

 

## Open access
HisTory And CliniCAl MAnifesTATions recommendation 1. Vigilance should be maintained for CVST. The possibility of CVST should be considered in patients presented with headache, papilloedema or increased intracranial pressure with unknown cause. The screening for CVST is reasonable in patients presented with unexplained seizures (including eclampsia), focal brain injury, different levels of unconsciousness, cognitive disorders, psychosis or dural arteriovenous fistula. (Class I, Level of Evidence C).
AuxiliAry exAMinATion recommendation 1. Routine blood tests consisting of a complete blood count, chemistry panel, prothrombin time, activated partial thromboplastin time, plasma protein and connective tissue disease or cancer markers are recommended in patients with suspected CVST. (Class I, Level of Evidence C) 2. Screening for potential prothrombotic factors (eg, antithrombin III, protein C or protein S deficiency, factor V Leiden, prothrombin mutation, anticardiolipin antibody, lupus anticoagulant) is recommended in patients with undetermined aetiology, recurrent CVST or a family history of venous thrombosis, to identify the root cause and select appropriate preventive and therapeutic strategies. (Class IIb, Level of Evidence C) 3. An elevated D-dimer level is considered to support the diagnosis of CVST, but a normal D-dimer level should not exclude CVST, especially in patients presented with isolated headache or chronic symptoms. between proximal and distal segment to the stenosis is beyond 8-10 mm Hg. (Class IIb, Level of Evidence C) 3. The long-term antithrombotic treatment after the sinus stenting is not clear. According to clinical practice in arterial stenting, it is reasonable to use dual antiplatelet therapy for the first 3 months followed by single antiplatelet therapy for maintenance. (Class IIb, Level of Evidence C)
TreATMenT of CvsT during PregnAnCy recommendation 1. LMWH is recommended in women with CVST during pregnancy. The safety of LMWH is superior to UFH. Subcutaneous injection of LMWH is recommended throughout the pregnancy (0.4 mL, twice a day), followed by LMWH or warfarin with a target INR of 2-3 for at least 6 weeks postpartum. The total duration of treatment is no less than 6 months. (Class I, Level of Evidence C)
Consensus on pre-operative total knee replacement education and prehabilitation recommendations: a UK-based modified Delphi study

This document provides recommendations on pre-operative care for patients waiting for total knee replacement (TKR) surgery in the United Kingdom.The recommendations were developed using an approach known as a Delphi Consensus Technique. This involved a group of patients and professionals, known as 'panel members', completing three online questionnaires. All the items included in this list of recommendations were rated as 'Important' or 'Very important' by at least 70% of panel members in the final questionnaire.Further details about the study used to develop the recommendations are available at: https://doi.

## Pre-operative total knee replacement care recommendations
This document provides recommendations on pre-operative care for patients waiting for total knee replacement (TKR) surgery in the United Kingdom.
The recommendations were developed using an approach known as a Delphi Consensus Technique. This involved a group of patients and professionals, known as 'panel members', completing three online questionnaires. All the items included in this list of recommendations were rated as 'Important' or 'Very important' by at least 70% of panel members in the final questionnaire.
Further details about the study used to develop the recommendations are available at: https://doi.org/10.1186/s12891-021-04160-5. A prioritised list of recommendations are available via the same link in Additional File 10. Other pre-operative treatments
Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines


[table] Table S1: Studies using TMS in patients with implanted stimulating/recording electrodes. [/table]
[table] Table S2: Randomized controlled multicenter trials investigating safety of rTMS in psychiatric disorders.Legend: MDD=major depressive disorder, # in the majority of studies sham TMS, serious adverse events (SAE), DLPFC = dorsolateral prefrontal cortex, NR = not reported. [/table]
[table] Table S3: Safety table for QPS parameters. [/table]
[table] Table S4: QPS studies.Total pulse number duration side effectsNo Table S5. TBS studies. [/table]
Guidelines on Parenteral Nutrition from the German Society for Nutritional Medicine (DGEM)  Overview



## Working group members (wg)
Adolph M 3 (WG 3, 6L, 14), Arends J 4 (WG 19L), Bauer K 5 (WG 13), Biesalski HK 6 (WG 7L), Bischoff SC 7 (WG 7L, 8L, 9, 12, 15), Blumenstein I 8 (WG 4), Bockenheimer-Lucius G 9 (WG 12), Boehles H-J 5 (WG 4, 7, 13), Bolder U 10 (WG 5L), Bra P 11 (WG 9), Celik I 12
2020 Clinical Practice Guideline for Percutaneous Transthoracic Needle Biopsy of Pulmonary Lesions: A Consensus Statement and Recommendations of the Korean Society of Thoracic Radiology



## Supplemental
Safe Reintroduction of Cardiovascular Services During the COVID-19 Pandemic



## Strategies and evidence
ETHICAL CONSIDERATIONS. Similar to rationing decisions made in preparation for the initial surge of COVID-19 cases, progressive and thoughtful reintroduction of CV services must be based on robust ethical analysis. Relevant values to be operationalized include: 1) maximizing benefits such that the most lives, or life years, are saved so that procedures or tests that are likely to benefit more people and to a greater degree are prioritized over procedures that will benefit fewer people to a lesser degree; 2) fairness such that like cases are treated alike, taking into consideration baseline health inequities; 3) proportionality such that the risk of further postponement is balanced against the risk of exacerbating COVID-19 spread; and 4) consistency such that reintroduction is managed across populations and among individuals regardless of ethically irrelevant factors such as ethnicity, perceived social worth, or ability to pay. Finally, the promotion of procedural justice, with the use of an ethical framework, is essential to ensure that all decisions reflect best available evidence with transparent communication. duction will change, and thus, we utilized "selective" cases and "some" or "most" CV procedures in.
Physical Therapist Management of Total Knee Arthroplasty

 

# Meta-analysis results

## Detailed data findings

## Summary of findings

## Summary of findings

# Detailed data tables
SIO management algorithm for patients with overweight or obesity: consensus statement of the Italian Society for Obesity (SIO)

 [bib_ref] Edmonton Obesity Staging System: association with weight history and mortality risk, Kuk [/bib_ref] 

# Strengths and limitations
The strength of the EOSS system relies on its ability to better identify patients who are at increased risk of mortality [bib_ref] Edmonton Obesity Staging System: association with weight history and mortality risk, Kuk [/bib_ref]. The limitations of the EOSS system have been clearly highlighted by Sharma and Kushner in their review paper . They recognize that definitions of some risk factors are subject to change. Furthermore, the EOSS system includes subjective parameters, such as psychological impact or functional performance, the assessment of which may vary among clinicians. In this regard, attention should be drawn to the vagueness of certain definitions such as mild psychopathology, anxiety disorder, significant psychopathology, and severe disabling psychopathology. In addition, the lack of any reference to eating disorders, in particular binge eating disorder, should be pointed out which since 2013 has been considered an autonomous diagnostic category by DSM-5.
By integrating the EOSS system, our therapeutic algorithmic chart includes its pros and cons. In addition, a specific limitation of our chart is the lack of evidence-based data.

# Conclusion
We believe that chronic diseases such as obesity have to be tackled with flexibility and understanding. Any treatment option should be thoroughly explained to the patient, sharing with him the rationale and cost-benefit ratio behind any proposed treatment; treatment that has to be ultimately tailored to the individual patient. However, any algorithm that may help clinicians in their delicate choices is always welcome. We hope this would be the case for our chart.
Finally, we did not indicate any level of evidence or strength of recommendation, since the proposed chart is based on expert opinions and since evidence is at the moment insufficient.
Saudi Oncology Society clinical management guideline series

A total of 195 case of pancreatic cancer have been diagnosed in the Kingdom of Saudi Arabia (KSA) in 2010 accounting for 2.5% of all cancers for that year. 1 The age standardized rate was 2.2/100,000 for males and 1.6/100,000 for females.A committee of experts in the medical and surgical treatment of pancreatic cancer was established under the supervision of the Saudi Oncology Society (SOS).The evidence adopted in these guidelines is rated at 3 levels: 1) Evidence level (EL)-1 (highest level) evidence from phase III randomized trials or meta-analyses; 2) EL-2 (intermediate-level) evidence from good phase II trials or phase III trials with limitations; and 3) EL-3 (low-level) from retrospective or observational data and/or expert opinion. This easy-to-follow grading system is convenient for the reader and allows accurate assessment of the applicability of the guidelines in individual patients.2All pancreatic cancer cases are preferably seen or discussed in a multidisciplinary form.

## Pre-treatment evaluation
1.1 Clinical examination, including age, performance status (PS), and degree of weight loss 1.2 Blood count, liver, and renal function 1.3 Tumor marker: CA19.9 level 1.4 Computed tomography (CT) scan of chest, abdomen, and pelvis (preferably triple phase, spiral) 5 (EL-1) 1.5 Endoscopic ultrasound (EUS) (optional)  fine-needle aspiration (EL-2) 1.6 Endoscopic retrograde cholangio-pancreatography (ERCP) (EL-2) 1.7 Positron emission tomography (PET) scan (optional) (EL-2) 1. [bib_ref] Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of..., Oettle [/bib_ref] 

## Supplements
* Supplements will be considered for work including proceedings of conferences or subject matter covering an important topic * Material can be in the form of original work or abstracts. * Material in supplements will be for the purpose of teaching rather than research. * The Guest Editor will ensure that the financial cost of production of the supplement is covered. * Supplements will be distributed with the regular issue of the journal but further copies can be ordered upon request. * Material will be made available on Saudi Medical Journal website
Clinical practice guideline of BRCA1/2 testing for patients with breast cancer: Chinese Society of Breast Surgery (CSBrS) practice guideline 2021

Supplementary File 3
Supplementary File 3
10.1001/jama.286.18.2251
Only extremely limited data are available on the specific use of selective estrogen receptor modulators (ie, tamoxifen, raloxifene) in patients with BRCA1/2 mutations. In NSABP-P1 study, tamoxifen reduced the risk for breast cancer by 50% in 11 BRCA2 mutation carriers, while failed to reduce the risk for breast cancer in 8 BRCA1 mutation carriers.[1]There is no evidence that aromatase inhibitors can reduce the risk of breast cancer in BRCA1/2 mutation carriers.
A Proposal to Develop New References for Serum IGF-I Levels in Children



## Ethics
Peer-review: Internally peer-reviewed.

# Financial disclosure:
The author declared that this study received no financial support.
 J Clin Res Pediatr Endocrinol 2020;12(2):140-142