Becaplermin (patient information)

# Why this medication is prescribed
Becaplermin is used to treat ulcers of the foot, ankle, or leg in patients with diabetes. Becaplermin is a human-platelet-derived growth factor, a substance naturally produced by the body that helps in wound healing. It works, in combination with good ulcer care (cleaning, pressure relief, and infection control), by bringing the cells that the body uses to repair wounds to the site of the ulcer.
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

# How this medication should be used
Becaplermin comes as a gel to apply to the skin. It is usually applied once daily to the ulcer. Your doctor or wound caregiver will tell you how much becaplermin gel to apply. The amount of gel to apply depends on the size of the ulcer. The amount you apply may be changed every 1 or 2 weeks as your ulcer heals. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use becaplermin exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor. Using more gel than your doctor prescribes will not make your ulcer heal faster.
To apply becaplermin gel, follow these steps:
- Wash your hands thoroughly.
- Squeeze the amount of gel your doctor has told you to use onto a clean, non-absorbent surface such as wax paper. The tip of the tube should not come in contact with the ulcer or any other surface. Recap the tube tightly after use.
- With a clean cotton swab, tongue depressor, or other applicator, spread the gel over the ulcer surface in an even layer about 1/16th of an inch thick.
- Moisten a piece of gauze dressing with saline (salt water) and cover the ulcer with the dressing.
- After about 12 hours, remove the gauze dressing and rinse the ulcer gently with saline or water to remove whatever gel is left.
- Cover the ulcer with a gauze dressing moistened with saline.
This drug must be used for a few weeks before your ulcer begins to heal. You may need to use becaplermin for up to 20 weeks. This drug must be used in combination with a good ulcer care program, including a strict non-weight-bearing program and good cleaning practices.

# Special precautions
Before using becaplermin:
- tell your doctor and pharmacist if you are allergic to becaplermin, parabens, or any other drugs.
- tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially other topical medications applied to the ulcer and vitamins and herbal products.
- tell your doctor if you have or have ever had a cancerous growth at the site of the ulcer.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using becaplermin, call your doctor.

# What to do if i forget a dose
Apply the missed dose as soon as you remember it. However, if it is almost time for the next application, skip the missed application and continue your regular application schedule. Do not apply a double amount of gel to make up for a missed application.

# Side Effects
Side effects from becaplermin can occur. Tell your doctor if this symptom is severe or does not go away:
- rash

# Storage conditions needed for this medication
Keep this medication in the refrigerator, tightly closed, and out of reach of children. Do not freeze it. Do not use the gel after the expiration date at the bottom of the tube. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

# Other information
Keep all appointments with your doctor and the laboratory.
Do not use becaplermin gel for other wounds or ulcers unless your doctor tells you to.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

# Brand names
- Regranex