Persius/hicric huggingface dataset:
Sloane Hospital for Women
The Sloane Hospital for Women is the obstetrics and gynecology service within New York-Presbyterian Hospital and the Department of Obstetrics and Gynecology of the Columbia University College of Physicians and Surgeons in New York City.
Sloane Maternity Hospital was founded in 1886 based upon a donation from William D. Sloane and his wife, Emily Thorn Vanderbilt Sloane, the granddaughter of Cornelius Vanderbilt, to Columbia P&S.  It was the first hospital in New York devoted to women's healthcare.  It was located on the P&S campus in Midtown Manhattan at Amsterdam Avenue and 59th Street, serving as a teaching facility for P&S students, and opened its doors in early 1888.  It soon established a reputation for superior sanitary practices and low mortality rates; it also linked obstetrics with gynecology, the first hospital in the country to do so.  The facility changed its name to Sloane Hospital for Women in 1910.  In 1911, a new surgical building was added, also funded by the Sloanes.  In 1925, it became part of Presbyterian Hospital, which was operating in affiliation with P&S.  During 1928, it moved to its present location on 168th Street in the Washington Heights area of northern Manhattan.  There it maintained its branding while occupying several floors of the Presbyterian Hospital building.
In its role as both a research and clinical facility, the Sloane Hospital for Women has pioneered many advances in the field, including the Apgar score, the use of rhogam, and amniocentesis.

# Notes
-  "Open Surgical Ward in Sloane Hospital". The New York Times. 1911-03-02. Retrieved 2007-10-30. Check date values in: |date= (help).mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"\"""\"""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{display:none;font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}
-  "Sloane Hospital Moves". The New York Times. 1928-06-05. Retrieved 2007-10-30. Check date values in: |date= (help)

# Sources
- Sloane Hospital for Women
- History of Sloane Hospital
Small nucleolar RNA TBR17
Small nucleolar RNA TBR17   is a non-coding RNA (ncRNA) molecule identified in Trypanosoma brucei which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.
snoRNA TBR17 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.
TBR17 was one of seventeen snoRNAs identified in  Trypanosoma brucei by immunoprecipiation with anti-fibrillarin antibodies .
Smp1p gene transcriptions
The transcription factor Smp1p as a response to osmotic stress (inducer) binds to the Saccharomyces cerevisiae promoters of STL1 and CWP1.
Is 'small myristoylated proteins' (SMPs) the same as (Smp)?

# Human genes

# Consensus sequences
The upstream activating sequence (UAS) for Smp1p is 5'-ACTACTA(T/A)4TAG-3' in the promoters of STL1 and CWP1 regarding osmotic stress response .

# SMP samplings
Copying the apparent consensus sequence for SMP (ACTACTA) and putting it in "F" finds none located between ZSCAN22 and none between ZNF497 and A1BG as can be found by the computer programs.
For the Basic programs testing consensus sequence ACTACTA(A/T)(A/T)(A/T)(A/T)TAG (starting with SuccessablesSMP.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:
- negative strand, negative direction, looking for ACTACTA(T/A)(T/A)(T/A)(T/A)TAG, 0.
- positive strand, negative direction, looking for ACTACTA(T/A)(T/A)(T/A)(T/A)TAG, 0.
- positive strand, positive direction, looking for ACTACTA(T/A)(T/A)(T/A)(T/A)TAG, 0.
- negative strand, positive direction, looking for ACTACTA(T/A)(T/A)(T/A)(T/A)TAG, 0.
- complement, negative strand, negative direction, looking for TGATGAT(A/T)(A/T)(A/T)(A/T)ATC, 0.
- complement, positive strand, negative direction, looking for TGATGAT(A/T)(A/T)(A/T)(A/T)ATC, 0.
- complement, positive strand, positive direction, looking for TGATGAT(A/T)(A/T)(A/T)(A/T)ATC, 0.
- complement, negative strand, positive direction, looking for TGATGAT(A/T)(A/T)(A/T)(A/T)ATC, 0.
- inverse complement, negative strand, negative direction, looking for CTA(A/T)(A/T)(A/T)(A/T)TAGTAGT, 0.
- inverse complement, positive strand, negative direction, looking for CTA(A/T)(A/T)(A/T)(A/T)TAGTAGT, 0.
- inverse complement, positive strand, positive direction, looking for CTA(A/T)(A/T)(A/T)(A/T)TAGTAGT, 0.
- inverse complement, negative strand, positive direction, looking for CTA(A/T)(A/T)(A/T)(A/T)TAGTAGT, 0.
- inverse negative strand, negative direction, looking for GAT(A/T)(A/T)(A/T)(A/T)ATCATCA, 0.
- inverse positive strand, negative direction, looking for GAT(A/T)(A/T)(A/T)(A/T)ATCATCA, 0.
- inverse positive strand, positive direction, looking for GAT(A/T)(A/T)(A/T)(A/T)ATCATCA, 0.
- inverse negative strand, positive direction, looking for GAT(A/T)(A/T)(A/T)(A/T)ATCATCA, 0.

# Acknowledgements
The content on this page was first contributed by: Henry A. Hoff.
Sneddon-Wilkinson disease
Synonyms and keywords: IgA pemphigus, subcorneal pustular dermatosis.

# Overview
IgA pemphigus is a subtype of pemphigus with two distinct forms:
- Subcorneal pustular dermatosis (also known as "SneddonWilkinson disease") (distinct from and not to be confused with subcorneal pustular dermatosis type of IgA pemphigus) is skin condition that is a rare, chronic, recurrent, pustular eruption characterized histopathologically by subcorneal pustules that contain abundant neutrophils.:203
- Intraepidermal neutrophilic IgA dermatosis is characterized histologically by intraepidermal bullae with neutrophils, some eosinophils, and acantholysis.

## Gallery

### Skin
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Solitary lymphatic nodule

# Overview
Solitary lymphatic nodules are structures found in the small intestine and large intestine.

# Small intestine
The solitary lymphatic nodules are found scattered throughout the mucous membrane of the small intestine, but are most numerous in the lower part of the ileum.
Their free surfaces are covered with rudimentary villi, except at the summits, and each gland is surrounded by the openings of the intestinal glands.
Each consists of a dense interlacing retiform tissue closely packed with lymph-corpuscles, and permeated with an abundant capillary network.
The interspaces of the retiform tissue are continuous with larger lymph spaces which surround the gland, through which they communicate with the lacteal system.
They are situated partly in the submucous tissue, partly in the mucous membrane, where they form slight projections of its epithelial layer.

# Large intestine
The solitary lymphatic nodules of the large intestine are most abundant in the cecum and vermiform process, but are irregularly scattered also over the rest of the intestine.
They are similar to those of the small intestine.
Specific gravity (kidney)

# Overview
Specific gravity, in the context of clinical pathology, is a urinalysis parameter commonly used in the evaluation of kidney function and can aid in the diagnosis of various renal diseases.

# Background
The role of the kidneys in humans and other mammals is to aid in the clearance of various water-soluble molecules, including toxins, toxicants, and metabolic waste.  The body excretes some of these waste molecules via urination, and the role of the kidney is to concentrate the urine, such that waste molecules can be excreted with minimal loss of water and nutrients. The specific gravity of urine is the concentration of these excreted molecules in urine, generally expressed in grams/milliliter (g/ml).  In humans, normal specific gravity values range from 1.002 to 1.028 g/ml

# Specific gravity and disease
Increases in specific gravity (i.e. increased concentration of solutes in the urine) may be associated with dehydration, diarrhea, emesis, excessive sweating, glucosuria, renal artery stenosis, hepatorenal syndrome, decreased blood flow to the kidney (as a result of heart failure), and excess of antidiuretic hormone caused by Syndrome of inappropriate antidiuretic hormone.
Decreased specific gravity (i.e. decreased concentration of solutes in urine) may be associated with renal failure, pyelonephritis, diabetes insipidus, acute tubular necrosis, interstitial nephritis, and excessive fluid intake (e.g., psychogenic polydipsia).
St. Mary's Hospital Lacor
St. Mary's Hospital Lacor, often referred to as Lacor Hospital, is a hospital in Gulu District, northern Uganda.  It was founded by Comboni missionaries and is run by the Gulu Catholic Diocese.  The hospital is located 6km west of Gulu town, in Gulu Municipality, Bardege subcounty, Opia village. The hospital is one of the best in East Africa.
During the violent and tyrannical reign of Idi Amin in the 1970s, the hospital was often caught in the crossfire. Throughout the 1980s, the hospital remained at constant risk as thugs repeatedly ransacked the compound, looking for drugs or petrol. Raiders kidnapped staff members and held them for ransom.
Founded in 1959 as a 30-bed hospital, by July 2005 it had 483 beds.  It also includes a nursing school and other health worker training programs and peripheral health centers (level III) in Opit and Pabbo with an additional 24 beds.  Each day the hospital hosts an average of 600 inpatients and their attendants, as well as 500 outpatients, for a daily total of about 2000.  Due to night time attacks and abduction by the rebel Lord's Resistance Army, between 2000 and 10,000 women and children crowd into the hospital compound nightly seeking a safe place to sleep.
The first surgeons at the hospital were Lucille Teasdale-Corti and Piero Corti, who arrived in 1961. Teasdale-Corti later died, in 1996, of the AIDS she had contracted from a patient while performing surgery. Other notable employees include Matthew Lukwiya, who was instrumental in containing a 2000 outbreak of Ebola, before succumbing to the disease himself.

# Notes
-  James Astill, "The death of Dr Matthew", The Observer, 2 January 2001
-  St. Mary's Hospital Lacor, FY 2004/2005 Annual Report, p. 4-5
-  Fonds Lucille Teasdale et Piero Corti, Library and Archives Canada
Standing gradient osmosis

# Overview
Water absorption at the colon typically proceeds against a transmucosal osmotic pressure gradient.
The standing gradient osmosis is a term used to describe the reabsorption of water against the osmotic gradiet at the colon.
This hypertonic fluid creates an osmotic pressure that drives water into the lateral intercellular spaces by osmosis via tight junctions and adjacent cells, which then in turn moves across the basement membrane and into the capillaries.
Streptomyces clavuligerus
Streptomyces clavuligerus is a species of Gram positive bacterium that produces clavulanic acid.
S. clavuligerus ATCC 27064 (NRRL 3585, DSM 738) was first described by Higgens and Kastner who isolated it from a South American soil sample. Its name refers to the shape of its spore-bearing hyphal branches: clavula in Latin means little club and the suffix -igerus means bearing. S. clavuligerus spores are gray to grayish green.
S. clavuligerus produces over 20 secondary metabolites, including many beta-lactam antibiotics such as clavulanic acid, cephamycin C, deacetoxycephalosporin C, penicillin N (an intermediate in cephamycin C pathway) and at least four other clavams. Non--lactam antibiotics include holomycin and an antibiotic complex, MM 19290, related to tunicamycin; a beta-lactamase-inhibitory protein (BLIP) has also been described.
Another important characteristic of S. clavuligerus is that it is not able to use glucose as a carbon source, because it lacks a glucose transport system.
It also possesses all the enzymes of the urea cycle, which is unusual for a prokaryote, although it is not clear if the urea cycle is functional.
Streptomycin microbiology

# Microbiology
Streptomycin sulfate is a bactericidal antibiotic. It acts by interfering with normal protein synthesis.
Streptomycin has been shown to be active against most strains of the following organisms both in vitro and in clinical infection. (See INDICATIONS AND USAGE.):
- Brucella (brucellosis)
- Calymmatobacterium granulomatis (donovanosis, granuloma inguinale)
- Escherichia coli in urinary tract infections
- Proteus spp. in urinary tract infections
- Aerobacter aerogenes in urinary tract infections
- Klebsiella pneumoniae in urinary tract infections
- Enterococcus faecalis in urinary tract infections
- Francisella tularensis
- Haemophilus ducreyi (chancroid)
- Haemophilus influenzae (in respiratory, endocardial, and meningeal infections - concomitantly with another antibacterial agent)
- Klebsiella pneumoniae pneumonia (concomitantly with another antibacterial agent)
- Mycobacterium tuberculosis
- Pasteurella pestis
- Streptococcus viridans (in endocardial infections - concomitantly with penicillin)
- Enterococcus faecalis (in endocardial infections - concomitantly with penicillin)

### Susceptibility Tests
Quantitative methods that require measurement of zone diameters give the most precise estimate of the susceptibility of bacteria to antimicrobial agents. One such standard procedure 1 which has been recommended for use with disks to test susceptibility of organisms to streptomycin uses the 10 mcg streptomycin disk. Interpretation involves the correlation of the diameter obtained in the disk test with the minimum inhibitory concentration (MIC) for streptomycin.
Reports from the laboratory giving results of the standard single disk susceptibility test with a 10 mcg streptomycin disk should be interpreted according to the following criteria:
Interpretive Criteria for Enterobacteriaceae
A report of Susceptible indicates that the pathogen is likely to respond to monotherapy with streptomycin. A report of Intermediate indicates that the result be considered equivocal, and, if the organism is not fully susceptible to alternative clinically feasible drugs, the test should be repeated. This category provides a buffer zone which prevents small uncontrolled technical factors from causing major discrepancies in interpretations. A report of Resistant indicates that achievable drug concentrations are unlikely to be inhibitory and other therapy should be selected.
Standardized procedures require the use of laboratory control organisms. The 10 mcg streptomycin disk should give the following zone diameter:
Acceptable Control Ranges
Interpretive Criteria for Agents of Bioterrorism
Stropharia rugosoannulata
Stropharia rugosoannulata, known as the wine-cap stropharia, burgundy mushroom or king stropharia, is an agaric of the family Strophariaceae found in Europe and North America, and introduced to New Zealand.
Unlike many other members of the genus Stropharia, it is widely regarded as a choice edible and cultivated for food.
The king stropharia can grow to 20 cm high with a reddish-brown convex to flattening cap up to 30 cm across, the size leading to another colloquial name godzilla mushroom. The gills are initially pale, then grey, and finally dark purple-brown in colour. The firm flesh is white, as is the tall stem which bears a wrinkled ring. This is the origin of the specific name which means "wrinkled-ringed".
It is found on wood chips and bark mulch across North America in summer and autumn. Described as very tasty by some authors, king stropharia is easily cultivated on a medium similar to what it grows on naturally. Antonio Carluccio recommends sauteeing them in butter or grilling them.
A 2006 study, published in the journal Applied and Environmental Microbiology, found the king stropharia to have the ability to attack the nematode Panagrellus redivivus; the fungus produces unique spiny cells called acanthocytes which are able to immobilise and digest the nematodes. See nematophagous fungus.

# Notes
-  Jump up to: 1.0 1.1 Carluccio A (2003). The Complete Mushroom Book. Quadrille. ISBN 1-84400-040-0..mw-parser-output cite.citation{font-style:inherit}.mw-parser-output q{quotes:"\"""\"""'""'"}.mw-parser-output code.cs1-code{color:inherit;background:inherit;border:inherit;padding:inherit}.mw-parser-output .cs1-lock-free a{background:url("")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-limited a,.mw-parser-output .cs1-lock-registration a{background:url("")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-lock-subscription a{background:url("")no-repeat;background-position:right .1em center}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration{color:#555}.mw-parser-output .cs1-subscription span,.mw-parser-output .cs1-registration span{border-bottom:1px dotted;cursor:help}.mw-parser-output .cs1-hidden-error{display:none;font-size:100%}.mw-parser-output .cs1-visible-error{display:none;font-size:100%}.mw-parser-output .cs1-subscription,.mw-parser-output .cs1-registration,.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left,.mw-parser-output .cs1-kern-wl-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right,.mw-parser-output .cs1-kern-wl-right{padding-right:0.2em}
-  Pacioni G (1981). Simon & Schusters Guide to Mushrooms. Simon & Schuster. ISBN 0-671-42849-7.
-  Hong Luo, Xuan Li, Guohong Li, Yanbo Pan, and Keqin Zhang (2006). "Acanthocytes of Stropharia rugosoannulata Function as a Nematode-Attacking Device". Appl. Environ. Microbiol. 72 (4): 29822987. doi:10.1128/AEM.72.4.2982-2987.2006. Check |doi= value (help).CS1 maint: Multiple names: authors list (link)
Subject-expectancy effect
The Subject-expectancy effect, in science, is a cognitive bias that occurs in science when a subject expects a given result and therefore unconsciously affects the outcome of an experiment or treatment, or reports the expected result. Because it can skew the results of experiments (especially on human subjects), double-blind methodology is used to eliminate the effect.
Like the Observer-expectancy effect, it is often a cause of "odd" results in many experiments.  The Subject-expectancy effect is most commonly found in medicine, where it can result in the subject experiencing the Placebo effect or nocebo effect, depending on how the influence pans out.
An example of a scenario involving these various effects is as follows: A woman goes to her doctor with an issue. The doctor diagnoses with certainty, and then clearly explains the diagnosis and the expected route towards recovery. If he does this convincingly, calming her, removing fear and installing hope, she will likely, through the positive expectancy, experience the placebo effect, aiding in her recovery. On the other hand, if her doctor had had little time for her, was uncertain about the diagnosis, and had given her a prescription, combined with a message along the lines of, "this may help sometimes," and added a message about possible horrible side effects (combined, say, with the patient having talked to a neighbor who also speaks along the same lines about the horrible side effect), then the chance of negative subject-expectancy, or nocebo, becomes quite large.
The subject expectancy effect is also clearly seen in psychotherapy.
Sulfanilamide description

# Description
AVC  is a preparation for vaginal administration for the treatment of Candida albicans infections and available in the following forms:
AVC Cream
Each tube contains:
Sulfanilamide.......15.0%
in a water-miscible, non-staining base made from lactose, propylene glycol, stearic acid, diglycol stearate, methylparaben, propylparaben, trolamine, and water; buffered with lactic acid to an acid pH of approximately 4.3.
Sulfanilamide is an anti-infective agent. It is p-amino-benzenesulfonamide with the chemical structure:
Sulfanilamide occurs as a white odorless crystalline powder with a slightly bitter taste and sweet aftertaste. It is slightly soluble in water, alcohol, acetone, glycerin, propylene glycol, hydrochloric acid, and solutions of potassium and sodium hydroxide. It is practically insoluble in chloroform, ether, benzene, and petroleum ether.
Superficial temporal vein
The superficial temporal vein is a vein of the side of the head.

# Path
It begins on the side and vertex of the skull in a plexus which communicates with the frontal vein and supraorbital vein, with the corresponding vein of the opposite side, and with the posterior auricular vein and occipital vein.
From this network frontal and parietal branches arise, and unite above the zygomatic arch to form the trunk of the vein, which is joined by the middle temporal vein emerging from the temporalis muscle.
It then crosses the posterior root of the zygomatic arch, enters the substance of the parotid gland, and unites with the internal maxillary vein to form the posterior facial vein.

# Tributaries
The superficial temporal vein receives in its course the following:
- some parotid veins
- articular veins from the temporomandibular joint
- anterior auricular veins from the auricula
- the transverse facial vein from the side of the face
Time in therapeutic range
Synonyms and Keywords: TTR

# Overview
Time in therapeutic range estimates the time a patient remains in the narrow therapeutic range of an international normalized ratio (INR) of 2-3. Going above this range increase your bleeding risk while going below steeply increases the risk of stroke.

# Factors Affecting Time in Therapeutic Range (TTR)
Cross trial comparisons of TTR are hampered by variations in:

## CHADS Score
A higher CHADS score is associated with a lower TTR. Sicker patients may have reduced access to frequent testing.

## Congestive Heart Failure (CHF)
The presence of congestive heart failure Varying drug clearance and distribution (CHF: 63% in ROCKET,  32% RELY, 35% ARISTOTLE)

## Country
The TTR is highest in Scandanavian countries (70% to 80%), and lowest in developing countries (40% to 50%)
Comparison of results across trials in TTR are inappropriate unless the TTR in each country should be compared, ROCKET AF in those countries who conducted RE-LY and vice versa (adjusting for the number of sites in each country).