The recommended immunization schedules for persons aged 0-18 years and the catchup immunization schedule for 2007 have been approved by the Advisory Committee on Immunization Practices, the American Academy of Pediatrics, and the American Academy of Family Physicians. The standard MMWR footnote format has been modified for publication of this schedule.#
The Advisory Committee on Immunization Practices (ACIP) periodically reviews the recommended immunization schedule for persons aged 0-18 years to ensure that the schedule is current with changes in vaccine formulations and reflects revised recommendations for the use of licensed vaccines, including those newly licensed.
The changes to the previous childhood and adolescent immunization schedule, published January 2006 (1), are as follows:
- The new rotavirus vaccine (Rota) is recommended in a 3-dose schedule at ages 2, 4, and 6 months. The first dose should be administered at ages 6 weeks through 12 weeks with subsequent doses administered at 4-10 week intervals. Rotavirus vaccination should not be initiated for infants aged >12 weeks and should not be administered after age 32 weeks (2). - The influenza vaccine is now recommended for all children aged 6-59 months (3). - Varicella vaccine recommendations are updated. The first dose should be administered at age 12-15 months, and a newly recommended second dose should be administered at age 4-6 years (4). - The new human papillomavirus vaccine (HPV) is recommended in a 3-dose schedule with the second and third doses administered 2 and 6 months after the first dose. Routine vaccination with HPV is recommended for females aged 11-12 years; the vaccination series can be started in females as young as age 9 years; and a catch-up vaccination is recommended for females aged 13-26 years who have not been vaccinated previously or who have not completed the full vaccine series (5).
- The main change to the format of the schedule is the division of the recommendation into two schedules: one schedule for persons aged 0-6 years (Figure 1) and another for persons aged 7-18 years (Figure 2). Special populations are represented with purple bars; the 11-12 years assessment is emphasized with the bold, capitalized fonts in the title of that column. Rota, HPV, and varicella vaccines are incorporated in the catch-up immunization schedule (Table ).

# Vaccine Information Statements
The National Childhood Vaccine Injury Act requires that health-care providers provide parents or patients with copies of Vaccine Information Statements before administering each dose of the vaccines listed in the schedule. Additional information is available from state health departments and from CDC at .
Detailed recommendations for using vaccines are available from package inserts, ACIP statements on specific vaccines, and the 2003 Red Book (6). ACIP statements for each recommended childhood vaccine are available from CDC at . In addition, guidance for obtaining and completing a Vaccine Adverse Event Reporting System form is available at http:// www.vaers.hhs.gov or by telephone, 800-822-7967.

# Hepatitis B vaccine (HepB). (Minimum age: birth)
At birth:
- Administer monovalent HepB to all newborns before hospital discharge.
- If mother is hepatitis surface antigen (HBsAg)-positive, administer HepB and 0.5 mL of hepatitis B immune globulin (HBIG) within 12 hours of birth. - If mother's HBsAg status is unknown, administer HepB within 12 hours of birth.
Determine the HBsAg status as soon as possible and if HBsAg-positive, administer HBIG (no later than age 1 week). - If mother is HBsAg-negative, the birth dose can only be delayed with physician's order and mothers' negative HBsAg laboratory report documented in the infant's medical record.

# After the birth dose:
- The HepB series should be completed with either monovalent HepB or a combination vaccine containing HepB. The second dose should be administered at age 1-2 months. The final dose should be administered at age >24 weeks. Infants born to HBsAg-positive mothers should be tested for HBsAg and antibody to HBsAg after completion of >3 doses of a licensed HepB series, at age 9-18 months (generally at the next well-child visit).

# 4-month dose:
- It is permissible to administer 4 doses of HepB when combination vaccines are administered after the birth dose. If monovalent HepB is used for doses after the birth dose, a dose at age 4 months is not needed.

# Rotavirus vaccine (Rota). (Minimum age: 6 weeks)
- Administer the first dose at age 6-12 weeks. Do not start the series later than age 12 weeks. - Administer the final dose in the series by age 32 weeks. Do not administer a dose later than age 32 weeks. - Data on safety and efficacy outside of these age ranges are insufficient.

# Diphtheria and tetanus toxoids and acellular pertussis vaccine (DTaP).
(Minimum age: 6 weeks)
- The fourth dose of DTaP may be administered as early as age 12 months, provided 6 months have elapsed since the third dose. - Administer the final dose in the series at age 4-6 years.

# Haemophilus influenzae type b conjugate vaccine (Hib). (Minimum age: 6 weeks)

# Human papillomavirus vaccine (HPV). (Minimum age: 9 years)
- Administer the first dose of the HPV vaccine series to females at age 11-12 years.
- Administer the second dose 2 months after the first dose and the third dose 6 months after the first dose. - Administer the HPV vaccine series to females at age 13-18 years if not previously vaccinated.

# Hepatitis B vaccine (HepB). (Minimum age: birth)
- Administer the 3-dose series to those who were not previously vaccinated.
- A 2-dose series of Recombivax HB  is licensed for children aged 11-15 years.

# Inactivated poliovirus vaccine (IPV). (Minimum age: 6 weeks)
- For children who received an all-IPV or all-oral poliovirus (OPV) series, a fourth dose is not necessary if the third dose was administered at age >4 years. - If both OPV and IPV were administered as part of a series, a total of 4 doses should be administered, regardless of the child's current age.

# Measles, mumps, and rubella vaccine (MMR). (Minimum age: 12 months)
- If not previously vaccinated, administer 2 doses of MMR during any visit, with >4 weeks between the doses. 10. Varicella vaccine. (Minimum age: 12 months)
- Administer 2 doses of varicella vaccine to persons without evidence of immunity.
- Administer 2 doses of varicella vaccine to persons aged 28 days after the first dose. - Administer 2 doses of varicella vaccine to persons aged >13 years at least 4 weeks apart.

# Rotavirus vaccine (Rota). (Minimum age: 6 weeks)
- Do not start the series later than age 12 weeks.
- Administer the final dose in the series by age 32 weeks. Do not administer a dose later than age 32 weeks. - Data on safety and efficacy outside of these age ranges are insufficient.

# Diphtheria and tetanus toxoids and acellular pertussis vaccine (DTaP).
(Minimum age: 6 weeks)
- The fifth dose is not necessary if the fourth dose was administered at age >4 years.
- DTaP is not indicated for persons aged >7 years.

# Haemophilus influenzae type b conjugate vaccine (Hib). (Minimum age: 6 weeks)
- Vaccine is not generally recommended for children aged >5 years.
- If current age <12 months and the first 2 doses were PRP-OMP (PedvaxHIB  or ComVax  ), the third (and final) dose should be administered at age 12-15 months and at least 8 weeks after the second dose. - If first dose was administered at age 7-11 months, administer 2 doses separated by 4 weeks plus a booster at age 12-15 months.

# Pneumococcal conjugate vaccine (PCV). (Minimum age: 6 weeks)
- Vaccine is not generally recommended for children aged >5 years.

# Inactivated poliovirus vaccine (IPV). (Minimum age: 6 weeks)
- For children who received an all-IPV or all-oral poliovirus (OPV) series, a fourth dose is not necessary if third dose was administered at age >4 years. - If both OPV and IPV were administered as part of a series, a total of 4 doses should be administered, regardless of the child's current age.

# Measles, mumps, and rubella vaccine (MMR

# Human papillomavirus vaccine (HPV). (Minimum age: 9 years)
- Administer the HPV vaccine series to females at age 13-18 years if not previously vaccinated.
The table below provides catch-up schedules and minimum intervals between doses for children whose vaccinations have been delayed. A vaccine series does not need to be restarted, regardless of the time that has elapsed between doses. Use the section appropriate for the child's age.
Information about reporting reactions after immunization is available online at  or by telephone via the 24-hour national toll-free information line 800-822-7967. Suspected cases of vaccine-preventable diseases should be reported to the state or local health department. Additional information, including precautions and contraindications for immunization, is available from the National Center for Immunization and Respiratory Diseases at  or telephone, 800-CDC-INFO (800-232-4636).