Sumatriptan injection (patient information)

# Why is this medication prescribed
Sumatriptan is used to treat the symptoms of migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound and light). Sumatriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the brain and by stopping pain signals from being sent to the brain. Sumatriptan does not prevent migraine attacks.

# How should this medicine be used
Sumatriptan is taken by injection, just under your skin, as soon as your migraine symptoms appear. You should feel relief of your symptoms within 1 hour (maybe within 10 minutes). If your symptoms then return after the first injection, you may take a second injection after 1 hour. But do not use more than two injections in a 24-hour period. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sumatriptan exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Sumatriptan comes in an autoinjection device so that you can self-inject this medication into your thigh or deltoid area (shoulder joint). Your doctor or pharmacist should show you how to load the injector and administer the medication. Also read the instruction pamphlet and be sure that you understand the correct injection technique before you use the autoinjector.
Try the autoinjector for the first time in your doctor's office so that he/she can be sure that you are using it correctly and can monitor any side effects.

# Other uses for this medicine
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

# What special precautions should I follow
Before using sumatriptan:
- tell your doctor and pharmacist if you are allergic to sumatriptan or any other drugs.
- do not use sumatriptan if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam) or tranylcypromine (Parnate) during the past 2 weeks or if you have taken another medication for migraine headaches such as dihydroergotamine (D.H.E. 45, Migranal), methysergide (Sansert), almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt, Maxalt-MLT), or zolmitriptan (Zomig) during the past 24 hours.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, herbal products and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine, paroxetine (Paxil), and sertraline (Zoloft), and selective serotonin/norepinephrine reuptake inhibitors (SNRIs) such as duloxetine (Cymbalta) and venlafaxine (Effexor). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you smoke, if you have a strong family history of heart disease, if you are postmenopausal, or if you are a man over 40. Also tell your doctor if you have or have ever had high blood pressure; angina (recurring chest pain); a heart attack; diabetes; high cholesterol; obesity; stroke; transient ischemic attack (mini-stroke); ischemic bowel disease; coronary artery disease; seizures; or blood vessel, kidney, or liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking sumatriptan, call your doctor.

# What should I do if I forget a dose
Sumatriptan is not for routine use. Use it only to relieve your migraine headache as soon as symptoms of the migraine appear.

# Side effects

## Mild side effects
Sumatriptan may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- pain or redness at the site of injection
- flushing
- tingling feeling
- feeling of warmth or heaviness
- drowsiness
- upset stomach
- vomiting
- muscle cramps

## Severe side effects
If you experience any of the following symptoms, call your doctor immediately:
- pain or tightness in chest or throat
- fast heartbeat
- difficulty breathing
- wheezing
- redness, swelling, or itching of the eyelids, face, or lips
- skin rash, lumps, or hives
- changes in vision

# What storage conditions are needed for this medicine
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature, away from light, excess heat, and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of needles, syringes, and the medication.

# In case of emergency/overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

# What other information should I know
Keep all appointments with your doctor.
Never inject this medication any place except under the skin of your thigh or shoulder.
Call your doctor if you continue to have symptoms.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

# Brand names
- Imitrex Injection