2014 Korean Guidelines for Appropriate Utilization of Cardiovascular Magnetic Resonance Imaging: A Joint Report of the Korean Society of Cardiology and the Korean Society of Radiology

 [bib_ref] CCS/CAR/CANM/CNCS/CanSCMR joint position statement on advanced noninvasive cardiac imaging using positron emission..., Beanlands [/bib_ref] [bib_ref] Clinical indications for cardiovascular magnetic resonance (CMR): Consensus Panel report, Pennell [/bib_ref] [bib_ref] appropriateness criteria for cardiac magnetic resonance imaging: a report of the Asian..., Cct [/bib_ref] 

## Methods for establishing the 2014 korean guidelines for appropriate utilization of cmr
The guidelines presented here were conjointly established by the Korean Society of Cardiology (KSC) and the Korean Society of Radiology (KSR). The two Societies decided to do a guideline adaptation of pre-existing guidelines and guideline development was based on the (Adaptation Process for Developing Korean Clinical Practice Guidelines) published by the Ministry of Health and Welfare in November 2011. The Clinical Practice Guideline Executive Committee of the Korean Academy of Medical Sciences (KAMS) was consulted for guideline development methods and a library search expert participated during the development of the 2014 Korean Guidelines. The Writing Committee was comprised of 4 members appointed by the Cardiovascular Imaging Research Group of the KSC and 4 members appointed by the Korean Society of Cardiovascular Imaging of the KSR. The Delphi method was used to develop and establish guidelines in consensus. The Rating Committee for the Delphi consensus process was comprised of 20 panelists who were appointed by the KSR and the KSC. The Writing Committee made a first draft of the Korean CMR guidelines by consolidating pre-existing guidelines and related research study results selected for guideline adaptation and the Committee then prepared a questionnaire based on this first draft. The final guidelines were established with the outcomes found by panels of the Rating Committee through three rounds of the Delphi consensus process. For the development of the 2014 Korean guidelines, we reviewed pre-existing utilization guidelines from US (5), Canada (1), Europe [bib_ref] Clinical indications for cardiovascular magnetic resonance (CMR): Consensus Panel report, Pennell [/bib_ref] , and Asia [bib_ref] appropriateness criteria for cardiac magnetic resonance imaging: a report of the Asian..., Cct [/bib_ref] , which were written in English.
searching formulas for each question, a review was done of the search results and evidential studies were selected for each related question. When a more recent systematic review or a meta-analysis study was found, papers previously published with lower levels of evidence were excluded along with case reports. Search formulas for each category are given in the Supplement (in the online-only Data Supplement).
The levels of evidence given in this guideline are stratified into 3 grades and are based on the levels of evidence for prognosis and diagnosis published by the Oxford Centre for Evidence-Based Medicine in 2011. A level of evidence, of either A, B, or C, is provided for each recommendation. The following table lists (Tables 1, 2) the levels of evidence and how the evidence was graded.
The appropriateness criteria was adapted from the 2010 American Heart Association cardiac CT appropriateness criteria and defined with three ratings: appropriate, uncertain, and inappropriate . Throughout the guidelines, the criteria is marked with A (Appropriate), U (Uncertain), or I (Inappropriate) (8).
The questionnaire was based on a first draft of the Korean guidelines and had 4 sections with a total of 52 questions. A survey was conducted a total of 3 times, and for each question, the appropriateness of CMR utilization was graded with a response scale; 1-3 points defining the use of CMR as inappropriate, 4-6 points as uncertain, and 7-9 points as appropriate. When more than 70% of the panelists agreed on a grade, the panel was considered to have reached consensus for that particular section. The report form for the Delphi consensus included appropriateness criteria from other guidelines for each category, levels of evidence based on searched literature, the response scale (9-point scale), sections available for panelists to write in other comments, and a reference list for each question. In following consensus rounds, questions for which agreement had not been reached had both their median score from the previous round and the score given in the previous round by the answering panelist listed. Response sections of questions for which agreement had been reached in previous rounds were covered in the questionnaires in the following rounds. No modifications were made to questions for which agreement had not been reached in the previous round and no other comments were written down on the questionnaires by any of the panelists. Of a total of 52 questions, a consensus was reached on 47 questions in the first survey, 4 questions in the second survey, and 1 remaining question on the third survey. The response rate for each round was 100%. The results of the Delphi voting are included in the Supplement (in the online-only Data Supplement).
A total of 10 members, consisting of 1 member of the Clinical Practice Guideline Executive Committee of the KAMS, 3 of the KSC, 3 of the Korean Pediatric Heart Association, and 3 of the KSR, reviewed the guidelines selected by consensus, which were later verified at an independent audit forum. The development of the current Case-control studies, or poor or non-independent reference standard/Case-series or case-control studies, or poor quality prognostic cohort study 5 Mechanism-based reasoning .

## Definition of appropriateness criteria
Appropriateness Criteria (Score) Definition A-Appropriate (7-9) Test is generally acceptable and a reasonable approach for the listed indication.
U-Uncertain (4-6)
Test may be generally acceptable and may be a reasonable approach for the indication. Uncertainty also implies that more patient evaluation or patient information is needed to classify the indication definitively.
[formula] I-Inappropriate (1-3) [/formula]
Test is not generally acceptable and is not a reasonable approach for the indication.
Korean J Radiol 15(6), Nov/Dec 2014 kjronline.org guidelines was funded by the KSC and KSR. However, the activities of the Writing Committee, the Rating Committee for the Delphi consensus and the Reviewing Committee that reviewed and verified the selected recommendations were independent of one another and none of the three Committees were influenced by any of the Societies funding the guideline development. These recommendations should be revised every 3-5 years, depending on the development of magnetic resonance imaging (MRI) technology, changes in the healthcare environment, and further accumulation of evidence associated with CMR.

## Contents

## Detection of coronary artery disease (cad): symptomatic

## Clinical scenario 1: evaluation of chest pain syndrome
There are several approaches to detect coronary artery disease (CAD) using CMR. These include direct visualization of coronary arteries using MR coronary angiography, and visualization of the effects of induced ischemia using stress CMR imaging. Stress CMR imaging can be performed with 2 different techniques: 1) dynamic first-pass perfusion imaging, which assesses inducible perfusion defects, indicative of impaired perfusion reserves; and 2) stressinducible wall motion abnormalities imaging, which evaluates the impairment of regional endocardial excursion and myocardial thickening, also indicative of underlying ischemia.

## Myocardial perfusion imaging
Cardiac magnetic resonance perfusion imaging is performed using a T1-weighted sequence to visualize the first passage of a gadolinium based contrast agent in transit through the heart. Following the intravenous injection, the contrast is detected against a background of nulled myocardium with rapid enhancement with and without vasodilation stress. Signal intensity correlates with contrast concentration, and analysis can be performed in a quantitative, semi-quantitative, or qualitative fashion. Visual interpretation is usually performed to identify dark areas of hypoperfusion relative to normally perfused segments. Semiquantification can be performed by measuring the upslope of myocardial signal increase (9). Deconvolution analysis allowing for the input function from the left ventricular (LV) blood pool signal curve can be used to generate regional values for the quantitative perfusion index and myocardial perfusion reserve (10).
Validation of CMR perfusion imaging in humans has been performed in a number of clinical studies employing a variety of contrast agents, analysis techniques, and reference standards (11-15). A meta-analysis of CMR perfusion studies demonstrated a sensitivity of 91% and a specificity of 81% for the diagnosis of CAD with  50% diameter stenosis using catheter-based X-ray coronary angiography (XCA) as a reference standard (16). The Magnetic Resonance Imaging for Myocardial Perfusion Assessment in Coronary Artery Disease Trial (MR-IMPACT) study of 241 patients compared the diagnostic performance of CMR perfusion imaging and single photon emission computed tomography (SPECT) and reported a similar overall accuracy (14). In a subsequent larger multicenter trial, MR-IMPACT II, of 533 patients, comparing CMR perfusion to SPECT suggests a higher sensitivity (75% vs. 52%, respectively) and lower specificity of CMR perfusion (59% vs. 72%, respectively) (15). When the investigators performed receiver operator characteristics curve analysis, the diagnostic performance estimated as area under the curve of CMR perfusion is superior to SPECT (17). However, there was a trend towards slightly lower sensitivity and specificity in the MR-IMPACT II study compared to the MR-IMPACT I study (75% vs. 85%, respectively; 59% vs. 67%, respectively). This might be related to the larger number of sites participating in the MR-IMPACT II study, in which less experienced centers might have contributed more to the database. Although CMR perfusion is currently thought to be an alternative to SPECT to detect perfusion deficit in CAD, appropriate physician and staff training and a facility capable of performing the stress test are required.

## Stress imaging of ventricular function
Cardiac magnetic resonance can detect myocardial ischemia using exercise and pharmacological stressors with an accuracy comparable to nuclear imaging and echocardiography (18-24). A meta-analysis of stressfunctional CMR studies demonstrated a sensitivity of 83% and a specificity of 86% for the demonstration of CAD with  50% diameter stenosis using catheter-based XCA (16). Since physical exercise is difficult to perform within the magnet bore and often induces motion artifacts, pharmacological stress is more commonly used. Dobutamine with and without atropine is the most common stressor Korean J Radiol 15(6), Nov/Dec 2014 kjronline.org used for assessment of inducible wall motion abnormalities . Breath-hold gradient echo or steady state free precession (SSFP) cines are used to examine regional wall function throughout the LV before and during stress as the dose of dobutamine is increased in a similar manner to dobutamine stress echocardiography. Dobutamine stress CMR has a high accuracy for detecting ischemia, related in part to excellent LV endocardial visualization throughout dobutamine/atropine stress protocols (20). Thus, dobutamine CMR appears to be valuable for patients who are unsuitable for dobutamine echocardiography (19). Dobutamine stress CMR exhibits major complications (i.e., the development of sustained ventricular tachycardia) in less than 0.1% of subjects, findings that are similar to those observed with dobutamine stress echocardiography (26).
Other CMR techniques have been used to assess CAD with dobutamine. Tagging methods have shown increased sensitivity for CAD diagnosis (27). Strain quantification using strain-encoded CMR allows early detection of inducible ischemia during intermediate stage (28). Real-time CMR may be used to monitor wall motion and may eliminate the need for breath-holding (24). However, further studies are required to determine the clinical role of these imaging techniques.

## Mr coronary angiography
MR coronary angiography is technically more challenging than MR angiography of other vascular beds due to the small caliber, tortuosity, and complex motion of the coronary arteries during the cardiac cycles, and the surrounding signal from adjacent epicardial fat and myocardium. To overcome these obstacles, several CMR approaches are employed. Cardiac triggering (e.g., vector electrocardiogram [ECG]) is used to account for intrinsic cardiac motion. Although breath-holding can be used to suppress respiratory motion, it has limited applicability of MR coronary angiography. Navigator echo method can be used for respiratory gating and enables free-breathing MR coronary angiography. Bright blood technique (segmented gradient echo and SSFP) is commonly used without a contrast agent, and pre-pulses (e.g., fat saturation, T2 preparation) are used to enhance the contrast-to-noise ratio of the coronary arterial blood. Recently, target-volume approach has been largely replaced by the whole-heart MR coronary angiography which allows visualization of all major coronary arteries with a single axial three-dimensional (3D) acquisition in a similar manner to that for CT coronary angiography.
Several studies evaluated the diagnostic performance of MR coronary angiography for detecting significant CAD (29-34). A prospective multicenter, free-breathing, 3D volumetargeted MR coronary angiography study demonstrated a very high sensitivity (100%) and a modestly high specificity (85%) with a very high negative predictive value (100%) of MR coronary angiography for the identification of left main and multi-vessel CAD (29). In a recent prospective multicenter study, SSFP whole-heart MR coronary angiography demonstrated a high sensitivity (88%) and moderate specificity (72%) with a high negative predictive value (88%) in the detection of significant CAD (31).
Clinical utilization of MR coronary angiography has been limited for the detection of CAD, mainly due to low spatial resolution and long imaging time. However, substantial progress in imaging hardware and techniques has been made during past decades. The introduction of 32-channel cardiac coils permits use of higher parallel imaging acceleration factors and substantially reduces the imaging time of MR coronary angiography within 10 minutes (35). The higher field, 3-T system provides better signal and contrast values relative to the 1.5-T system, and thus, may improve the detection of CAD with MR coronary angiography (32). A recent comparison study of 3-T MR coronary angiography with 32-channel cardiac coils and 64-slice CT demonstrated similar diagnostic accuracy between the two techniques (33). However, to date, data regarding the clinical utility of MR coronary angiography for the evaluation of CAD are based on high-risk populations referred for catheterbased XCA. And, importantly, the majority of MR coronary angiography data has been generated in only a few highly specialized centers.

## Cmr for prognosis assessment
Prognostic data are now available using both vasodilator and dobutamine stress functional CMR methods (36-39). In a recent meta-analysis, the annualized event rates for composite outcome of cardiovascular death and myocardial infarction were 4.9% for positive versus 0.8% for a negative stress CMR (39). Another meta-analysis demonstrated a high negative predictive value of 98% for cardiac death and myocardial infarction of negative stress CMR, and showed a similar ability to identify low-risk patients with known or suspected CAD (38). In patients with suspected or known CAD, stress CMR has excellent prognostic value and may Korean J Radiol 15(6), Nov/Dec 2014 kjronline.org help guide risk stratification. However, data on prognostic value of MR coronary angiography is limited. Only a recent single study, including 207 patients with suspected CAD, reported that significant stenosis detected by MR coronary angiography can be used to identify patients at high risk for subsequent adverse cardiac events, whereas normal MR coronary angiography results are associated with a very low event rate (40).

## Detection of cad: symptomatic

## Clinical scenario 2: evaluation of coronary artery anomaly (use of mr coronary angiography)
Coronary artery anomalies are a diverse group of congenital disorders with manifestations and pathophysiological mechanisms that are highly variable. Although the majority of coronary artery anomalies are not thought to be hemodynamically significant, anomalous origination of a coronary artery from the opposite sinus with subsequent passage between the aorta and pulmonary artery is a wellrecognized cause of myocardial ischemia and sudden cardiac death in young individuals (41). Traditionally, catheterbased XCA has been used to identify these anomalies. However, XCA only provides a two-dimensional (2D) view, thus the complex 3D course of the anomalous vessel, especially in respect to the aorta and pulmonary artery, may be difficult to discern. Furthermore, the presence of an anomalous vessel is sometimes only suspected even after an invasive angiography, because of an unsuccessful engagement and visualization of the coronary artery. CT coronary angiography and MR coronary angiography are alternatives to XCA, which are noninvasive and have the multi-planar capability of providing 3D images. MR coronary angiography has several significant advantages over XCA and CT coronary angiography for diagnosing coronary artery anomalies: MR coronary angiography does not expose patients to ionizing radiation and can be performed without administration of contrast agents at 1.5-T. This is an important consideration especially in adolescents and younger adults with suspected anomalous CAD. Both 2D breath-hold and targeted 3D or free-breathing navigator whole-heart MR coronary angiographic methods have been used with similar excellent results. However, 3D whole-heart MR coronary angiography with a single axial 3D acquisition has become the method of choice for MR coronary imaging, and is thought to have marked utility relative to the 2D projection technique in the assessment of coronary artery anomalies (42-47).

## Evaluation of intracardiac structures (use of mr coronary angiography)
1. Evaluation of suspected coronary anomalies (Level of evidence: B, Appropriateness criteria: A)

## Clinical scenario 3: acute chest pain
The use of CMR in the emergency department may allow for a more rapid and comprehensive evaluation of patients. The unique advantage of CMR imaging is that it can provide information on myocardial function, perfusion, and infarction in a single scanning session. However, to date, there is a paucity of data regarding the utility of CMR in the triage of acute chest pain patients. By combining the assessment of the left ventricular function, adenosine stress perfusion, and late gadolinium enhancement (LGE) imaging, CMR demonstrated a sensitivity of 96% and a specificity of 83% for the detection of significant stenosis in 68 patients with non-ST-segment elevation myocardial infarction (48). Otherwise, there have only been 2 small single-center observational trials in patients with acute chest pain and an inconclusive evaluation in the emergency department. CMR including the LV function, resting perfusion, and LGE imaging was performed in 161 patients with acute chest pain and showed a sensitivity of 84% and a specificity of 85%, respectively (49). In a smaller study with 62 patients, the addition of the T2-weighted sequence for the detection of myocardial edema improved the specificity and positive predictive value for acute coronary syndrome to 96% and 85% (50). Management of intermediate-risk patients with Korean J Radiol 15(6), Nov/Dec 2014 kjronline.org possible acute coronary syndrome in an observational unit with CMR may reduce medical costs during the index visit and subsequent to discharge over the first year (51). The reduction in costs even after discharge is thought to be associated with fewer coronary artery revascularizations, fewer hospital readmissions, and fewer cases of recurrent cardiac testing [bib_ref] Stress CMR reduces revascularization, hospital readmission, and recurrent cardiac testing in intermediaterisk..., Miller [/bib_ref]. However, as with the diagnostic accuracy literature for CMR, studies in this area are primarily single-center reports that describe the findings of experienced observers in a small number of patients. Thus, at present, the level of evidence is low, and larger multicenter investigations should further build on these results.

## Acute chest pain (protocols may include vasodilator perfusion cmr or dobutamine stress function cmr)

## Clinical scenario 4: detection of cad with prior test results
An important decision facing clinicians is whether a noninvasive cardiac imaging result warrants revascularization or whether medical management is most appropriate. Current guidelines recommend proof of ischemia prior to elective revascularization [bib_ref] Physiological assessment of coronary artery disease in the cardiac catheterization laboratory: a..., Kern [/bib_ref] [bib_ref] ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the..., Smith [/bib_ref] [bib_ref] ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the..., Smith [/bib_ref]. However, the severity of coronary stenosis assessed by catheter-based XCA or CT coronary angiography does not correlate well with functional significance assessed by the fractional flow reserve (FFR) [bib_ref] Comprehensive assessment of coronary artery stenoses: computed tomography coronary angiography versus conventional..., Meijboom [/bib_ref]. The relevance of this discrepancy has been highlighted by results of the Fractional Flow Reserve versus Angiography for Multivessel Evaluation (FAME) trial, which demonstrated improved cardiac outcome when FFR measurements were taken during coronary intervention for multi-vessel disease [bib_ref] Fractional flow reserve versus angiography for guiding percutaneous coronary intervention, Tonino [/bib_ref] [bib_ref] Fractional flow reserve versus angiography for guiding percutaneous coronary intervention in patients..., Pijls [/bib_ref]. These results show the importance of assessing the functional significance of CAD in addition to anatomic evaluation, supporting the use of noninvasive testing for guiding revascularization.
Stress CMR, either with vasodilator or dobutamine stress, has been shown to have high diagnostic accuracy for the detection of significant CAD (13-16, 59). Several studies have compared stress CMR perfusion imaging with the invasive reference standard, FFR, and have demonstrated good correlation between stress CMR perfusion imaging and FFR [bib_ref] Cardiac magnetic resonance perfusion imaging for the functional assessment of coronary artery..., Rieber [/bib_ref] [bib_ref] Quantitative magnetic resonance perfusion imaging detects anatomic and physiologic coronary artery disease..., Costa [/bib_ref] [bib_ref] Validation of magnetic resonance myocardial perfusion imaging with fractional flow reserve for..., Watkins [/bib_ref] [bib_ref] High-resolution magnetic resonance myocardial perfusion imaging at 3.0-Tesla to detect hemodynamically significant..., Lockie [/bib_ref]. In a single center study by Watkins et al. [bib_ref] Validation of magnetic resonance myocardial perfusion imaging with fractional flow reserve for..., Watkins [/bib_ref] , 103 patients with suspected angina underwent stress CMR perfusion imaging and catheter-based XCA and FFR was measured in all major patent epicardial coronary arteries. Stress CMR perfusion imaging can detect functionally significant CAD defined as FFR < 0.75 with excellent sensitivity (91%), specificity (94%), and positive and negative predictive values (91% and 94%, respectively). In a recent study by , the addition of stress CMR perfusion imaging to CT coronary angiography significantly improved specificity and overall diagnostic accuracy for the detection of significant CAD as defined by catheter-based XCA with conditional FFR measurement. Thus, in clinical practice, stress CMR can subsequently be used to assess the hemodynamic significance of CAD and to direct revascularization.
Stress CMR provides excellent prognostic stratification of patients with known or suspected CAD with a high negative predictive value for adverse cardiac events (38, 39). Further, it has a number of advantages over the other noninvasive techniques, including high spatial and temporal resolution, no exposure to ionizing radiation, no attenuation or scatter artifacts, and no image orientation constraints. However, it is currently difficult to conclude that using ischemic burden to guide the decision for revascularization with stress CMR is superior compared to other noninvasive tests. Although a few previous studies have reported a higher diagnostic accuracy of stress CMR in comparison to myocardial SPECT, the majority of studies have compared diagnostic accuracy for the detection of significant CAD, using catheter-based XCA as the reference standard (13-15, 17, 65). It needs to be confirmed whether stress CMR guided revascularization truly achieves a therapeutic reduction in ischemia or truly improves outcomes.
Combining stress perfusion and wall motion assessment with LGE and/or coronary artery anatomy may further increase the diagnostic and prognostic power of stress CMR. In a large prospective study entitled Cardiovascular Magnetic Resonance and Single-photon Emission Computed Korean J Radiol 15(6), Nov/Dec 2014 kjronline.org Tomography for Diagnosis of Coronary Heart Disease (CE-MARC), multiparametric CMR including LV function, stress perfusion, LGE, and MR coronary angiography, demonstrated superior diagnostic accuracy compared to SPECT (13). However, further studies are necessary to determine whether LGE or MR coronary angiography provides incremental information to stress CMR in the decision making process for revascularization.

## Detection of cad: with prior test results (protocols may include vasodilator perfusion cmr or dobutamine stress function cmr)

## Clinical scenario 5: evaluation of cad in patients with post percutaneous coronary intervention (pci) or coronary artery bypass grafting (cabg)
Several studies had reported that 10% of postoperative grafts had been occluded either during or immediately after coronary artery bypass grafting (CABG). Moreover, in a 10 year follow-up study after the surgery, 59% of vein grafts and 17% of artery grafts had been occluded [bib_ref] The biology of saphenous vein graft occlusion: etiology and strategies for prevention, Bryan [/bib_ref] [bib_ref] Twelve-year experience with internal mammary artery for coronary artery bypass, Barner [/bib_ref] [bib_ref] Recurrence of angina after coronary artery bypass surgery: predictors and prognosis (CASS..., Cameron [/bib_ref]. Therefore, reliable diagnostic methods for patency assessment are needed after CABG. Cardiac CT and CMR are noninvasive methods geared toward this end. Some studies have shown that high-resolution MR angiography provides fair diagnostic accuracy in evaluating the severity of vein graft stenosis comparing with invasive coronary angiography in patients with recurrent chest pain or in asymptomatic patients after bypass surgery [bib_ref] Detection of vein graft disease using highresolution magnetic resonance angiography, Langerak [/bib_ref] [bib_ref] Value of magnetic resonance imaging in assessing patency and function of coronary..., Galjee [/bib_ref]. However, until now, most studies used cardiac CT to assess graft vessel patency after CABG and only a small number of studies utilized CMR for this purpose. Therefore, further studies on CMR in this capacity are warranted.
Regular clinical evaluation of stent restenosis is recommended in patients who have undergone percutaneous coronary intervention (PCI) with stent placement [bib_ref] ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention: a report of the..., Smith [/bib_ref].
Although several studies had suggested that CMR imaging of coronary stents is a safe and promising non-invasive method that assessing patency of the coronary stents [bib_ref] Assessment of coronary artery patency after stent placement using magnetic resonance angiography, Duerinckx [/bib_ref] [bib_ref] MR evaluation of coronary stents with navigator echo and breath-hold cine gradient-echo..., Sardanelli [/bib_ref] [bib_ref] MRI assessment of coronary stents, De Cobelli [/bib_ref] , the use of MR coronary angiography for this purpose is limited by low-signal artifacts that occur at the stenting site and direct evaluation of in-stent restenosis is not possible. Therefore, MR coronary angiography is not recommended as an appropriate method for the routine evaluation of in-stent restenosis. Also, the indirect approach of inferring the degree of stenosis through the presence of distal flow turbulence has been known to have little credibility [bib_ref] Coronary MR angiography after coronary stent placement, Duerinckx [/bib_ref].

## Evaluation of cad: post pci or cabg

## Clinical scenario 6: cad risk assessment: preoperative evaluation
The decision to conduct a preoperative cardiac evaluation is made based on the surgery-specific cardiac risk and patients scheduled for low-risk surgery can proceed to the surgery without further testing. However, when an intermediate-to high-risk surgery is scheduled, for which the risk of a myocardial infarction or cardiac mortality is around 5%, additional cardiac evaluation may be necessary [bib_ref] Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgery: Executive Summary:..., Fleisher [/bib_ref] [bib_ref] guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: a report..., Fleisher [/bib_ref] [bib_ref] Perioperative cardiovascular assessment of patients undergoing noncardiac surgery, Freeman [/bib_ref] [bib_ref] Perioperative cardiac risk reduction, Holt [/bib_ref]. Additional heart tests are required when three or more clinical risk factors are present or when patient's functional capacity is poor. Because there is an increased risk associated with surgery, a noninvasive cardiac stress test is recommended before surgery [bib_ref] Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgery: Executive Summary:..., Fleisher [/bib_ref] [bib_ref] guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: a report..., Fleisher [/bib_ref] [bib_ref] Relation of clinical and angiographic factors to functional capacity as measured by..., Nelson [/bib_ref].
As a noninvasive preoperative cardiac testing method, CMR has the advantages of providing superior spatial and temporal resolution without exposure to harmful radiation in contrast to cardiac CT or myocardial perfusion scintigraphy, and of having more precision in cardiac Korean J Radiol 15(6), Nov/Dec 2014 kjronline.org evaluation than echocardiography in case with a poor acoustic window. Therefore, CMR has recently been used more frequently in clinical practice as a preoperative test for myocardial viability and perfusion, valvular heart disease, cardiomyopathy, and congenital heart disease [bib_ref] Role of multimodality cardiac imaging in preoperative cardiovascular evaluation before noncardiac surgery, Fathala [/bib_ref]. In particular, in patients who showed a negative stress perfusion CMR examination, the probability of not experiencing cardiac death or a nonfatal myocardial infarction for at least 3 years is as high as 99.2%, indicating a very low likelihood of future cardiovascular disease (37). Additionally, in meta-analysis of 21 studies that observed a total of 1233 subjects, stress perfusion CMR examination scored high on its ability to assess obstructive CAD with a sensitivity of 84% (range, 44-93%) and a specificity of 80% (range, 60-100%); therefore, CMR is thought to be very useful in the preoperative assessment of CAD (37, 83). Furthermore, CMR is known for its excellence in assessing the LV ejection fraction and LV volume, which predicts the occurrence of postoperative heart failure. However, a disadvantage that must be mentioned is the difficulty of performing a CMR examination in patients with an artificial pacemaker, implantable defibrillator, or insulin pump. Thus, the patient's condition should be taken into account when performing CMR.

## Cad risk assessment: preoperative evaluation (protocols may include vasodilator perfusion cmr or

## Clinical scenario 7: evaluation of cad: in pediatric patients with kawasaki disease
Echocardiography is the bedside technique of choice during the acute phase of the disease. CMR can be a valuable tool especially in children and adolescents, where sometimes echocardiography fails to detect coronary abnormalities and it has also the advantage of simultaneous perfusion, function and viability evaluation. If CMR is not available, a combination of echocardiography and SPECT gives an overview of anatomy, function and perfusion. Cardiac CT is of limited value for follow-up because of radiation and the misleading data due to coronary calcifications. Catheter-based XCA is kept mainly for cases where an invasive procedure should be performed [bib_ref] How to image Kawasaki disease: a validation of different imaging techniques, Mavrogeni [/bib_ref]. Mavrogeni et al. [bib_ref] Magnetic resonance angiography is equivalent to X-ray coronary angiography for the evaluation..., Mavrogeni [/bib_ref] [bib_ref] Magnetic resonance angiography, function and viability evaluation in patients with Kawasaki disease, Mavrogeni [/bib_ref] compared the results of MR coronary angiography with XCA in a pediatric population [bib_ref] Coronary magnetic resonance angiography in adolescents and young adults with kawasaki disease, Greil [/bib_ref]. In the 6 patients, aneurysms of the coronary arteries were identified, while coronary ectasia alone was present in the remaining seven patients. MR coronary angiography and XCA diagnosis of coronary artery aneurysm (CAA) agreed completely. Maximal aneurysm diameter and length and ectasia diameter by MRA and XCA were similar. No stenotic lesion was identified by either technique. Another prospective study compared MR coronary angiography and XCA findings in patients with CAAs. There was complete agreement between MR coronary angiography and XCA in the detection of CAA (n = 11), coronary artery stenoses (n = 2), and coronary occlusions (n = 2). Excellent agreement was found between the 2 techniques for detection of CAA maximal diameter (mean difference = 0.4  0.6 mm) and length (mean difference = 1.4  1.6 mm). The 2 methods showed very similar results for proximal coronary artery diameter and CAA distance from the ostia [bib_ref] Coronary magnetic resonance angiography and vessel wall imaging in children with Kawasaki..., Greil [/bib_ref].

## Evaluation of cad: in pediatric patients with

## Clinical scenario 8: detection of cad: asymptomatic
Regarding role of CMR for detecting occult CAD, no well controlled studies have been reported. Especially, no efficacy data have been reported regarding "screening" MR coronary angiography in high-risk populations. Although other imaging modalities such as coronary calcium scoring has some evidences for risk stratifications in asymptomatic populations, CMR based stress perfusion study or MR coronary angiography based CAD detection need evidence to get any appropriateness levels. Therefore in this category of patients, performing CMR is not generally recommended in low-or intermediate-risk populations. Regarding in high risk asymptomatic populations, experts' recommendations from ASCI provide uncertain level with scoring 6, which means it may be a "reasonable approach" [bib_ref] Systematic review of guidelines on imaging of asymptomatic coronary artery disease, Ferket [/bib_ref].

## Detection of cad: asymptomatic (protocols may include vasodilator perfusion cmr, dobutamine stress function cmr, and/or mr coronary angiography)
1. Low CHD risk (Framingham) (Level of evidence: A, Appropriateness criteria: I) 2. Moderate CHD risk (Framingham) (Level of evidence:
A, Appropriateness criteria: U) 3. High CHD risk (Framingham) (Level of evidence: A, Appropriateness criteria: U)

## Clinical scenario 9: detection of myocardial scar and viability in ischemic heart disease
In patients with ischemic heart disease, discrimination of unviable necrotic areas from a viable area such as a stunned myocardium is important in the prediction of the potential recoverability of myocardial contractility and in the planning of future treatment directions. Contrastenhanced CMR that uses gadolinium has been reported to be useful in the evaluation of myocardial viability by many studies. Contrast-enhanced CMR can also be performed on myocardial infarction patients before coronary artery revascularization to predict the post-procedural reversibility of myocardial contractility [bib_ref] Transmural extent of acute myocardial infarction predicts long-term improvement in contractile function, Choi [/bib_ref] [bib_ref] The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction, Kim [/bib_ref]. A recent meta-analysis that evaluated the ability of LGE CMR to discern stunned myocardium that may be reversible in patients with myocardial infarction scheduled for coronary revascularization reported sensitivity of 87%, a specificity of 68%, a positive predictive value of 83%, and a negative predictive value of 72%, for an overall diagnostic accuracy of 82% in those surveyed. The dobutamine stress CMR technique was also evaluated and was found a sensitivity of 67%, a specificity of 81%, a positive predictive value of 82%, a negative predictive value of 63%, and an overall diagnostic accuracy of 74%. Therefore, CMR was founded to be useful in the evaluation of myocardial viability [bib_ref] CMR imaging for the evaluation of myocardial stunning after acute myocardial infarction:..., Romero [/bib_ref]. Furthermore, in a meta-analysis of 4438 CAD patients, when the CMR examination detected LGE lesions, patients had a 2.65 (95% confidence interval [CI], 1.98-3.56) greater risk of developing major cardiovascular events (MACE), and a relationship to the size of the LGE in the lesion was found with every 10% of the LV affected leading to a 56% (95% CI, 1.39-1.75) increase in MACE development. These reports support the useful prognostic value of CMR in predicting MACE in patients with prior myocardial infarction [bib_ref] Prognostic utility of late gadolinium enhancement cardiac magnetic resonance imaging in coronary..., Chan [/bib_ref]. Thus, based on reports of its usefulness in patients scheduled for coronary revascularization, CMR has become a recognized pre-procedural assessment method of the viability of cardiac function recovery.
Many studies have reported that dobutamine stress CMR and LGE CMR are important in the evaluation of myocardial viability. In particular, Romero et al. [bib_ref] CMR imaging assessing viability in patients with chronic ventricular dysfunction due to..., Romero [/bib_ref] reported in a meta-analysis of 24 studies including 698 patients, that LGE CMR scored high with a sensitivity and negative predictive value of 95% and 90%, respectively, and that dobutamine stress CMR scored 91% and 93% on specificity and positive predictive value, respectively. They therefore concluded that a more accurate prediction of cardiac function after coronary revascularization can be achieved by analyzing the results of several studies [bib_ref] CMR imaging assessing viability in patients with chronic ventricular dysfunction due to..., Romero [/bib_ref] [bib_ref] Dobutamine magnetic resonance imaging as a predictor of myocardial functional recovery after..., Trent [/bib_ref] [bib_ref] Value of delayed-enhancement cardiovascular magnetic resonance imaging in predicting myocardial viability after..., Selvanayagam [/bib_ref].
Late gadolinium enhancement CMR was also compared to other noninvasive tests for myocardial viability, such as dobutamine stress echocardiography and SPECT. First, when comparing SPECT to CMR, while there was no significant difference in each method's ability to detect myocardial transmural necrosis or normal myocardium, LGE CMR was superior to SPECT in the detection of subendocardial infarction owing to its superior spatial resolution [bib_ref] Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging..., Wagner [/bib_ref] [bib_ref] Agreement and disagreement Appropriate Use Criteria for CMR, Roes [/bib_ref] [bib_ref] Assessment of Myocardial Scar; Comparison Between F-FDG PET, CMR and Tc-Sestamibi, Crean [/bib_ref]. In addition, a recent prospective study has shown that CMR has a sensitivity of 86.5% and a specificity of 83.4% in the detection of CAD, which are superior to the 66.5% sensitivity and 82.6% specificity reported for SPECT (13).
Likewise, CMR appears to be superior to dobutamine stress echocardiography, which is known to have a similar overall accuracy to that of SPECT on the basis of a meta-analysis that compiled 11 studies and reported a sensitivity of 79% and specificity of 87% [bib_ref] Stress echocardiography, stress single-photon-emission computed tomography and electron beam computed tomography for..., Heijenbrok-Kal [/bib_ref]. Taken together, these results indicate that stress CMR has a special significance Korean J Radiol 15(6), Nov/Dec 2014 kjronline.org for patients who tested negative for low to moderate risk of CAD and for patients who tested positive for a high risk of CAD. CMR has therefore been shown to be effective for patients who tested as being moderately at risk by other noninvasive examination methods (16).
As previously described, it is known that LGE CMR is a good method for evaluating the size of myocardial necrosis prior to coronary revascularization and for determining whether or not myocardial necrosis after coronary revascularization is likely to occur and to what extent. When observing patients scheduled for PCI, an increase in post-procedural troponin I level has been reported to show a strong positive correlation to the area of new myocardial enhancement as detected by LGE CMR. Moreover, in patients with an elevated level of creatinine kinase-MB, which indicates necrosis of the myocardium, LGE could be observed in structurally associated parts, indicating that it is possible to check for incidence of immediate postprocedural myocardial infarction [bib_ref] Long-term prognostic value of myocardial salvage assessed by cardiovascular magnetic resonance in..., Eitel [/bib_ref]. Based on their research studies on acute ST elevated myocardial infarction patients, Eitel et al. [bib_ref] Long-term prognostic value of myocardial salvage assessed by cardiovascular magnetic resonance in..., Eitel [/bib_ref] [bib_ref] Prognostic significance and determinants of myocardial salvage assessed by cardiovascular magnetic resonance..., Eitel [/bib_ref] concluded that the myocardial salvage index measured by CMR is related to the incidence of long-term MACE such as cardiac death and that it is therefore an important independent prognostic factor.
Thus, it is believed that the implementation of CMR after coronary revascularization procedures can help assess the incidence of myocardial injury and that CMR can find further application as an indicator of patient prognosis [bib_ref] Troponin elevation after percutaneous coronary intervention directly represents the extent of irreversible..., Selvanayagam [/bib_ref].

## Detection of myocardial scar and viability (protocols may include lge evaluation or dobutamine stress

## Structure and myocardial functional evaluation in patients with risk of heart failure or overt heart failure

## Clinical scenario 10: evaluation in patients with risk of heart failure or overt heart failure (general)
The main symptoms of heart failure include shortness of breath, fatigue, and exercise intolerance, resulting from variable combinations of fluid retention in the body and significant decline in tissue perfusion [bib_ref] ESC Guidelines for the diagnosis and treatment of acute and chronic heart..., Mcmurray [/bib_ref]. Physical examination in heart failure patients can reveal cardiac murmur, jugular venous engorgement, pedal edema, crackles, and/or cold extremities, depending on the heart failure severity [bib_ref] ESC Guidelines for the diagnosis and treatment of acute and chronic heart..., Mcmurray [/bib_ref]. Heart failure is characterized by an abnormality of cardiac structure and/or function, leading to the impairment of the heart ability to meet the oxygen requirements of the tissues [bib_ref] ESC Guidelines for the diagnosis and treatment of acute and chronic heart..., Mcmurray [/bib_ref]. Therefore, any cardiac diseases at the terminal stages can clinically cause heart failure. Although the definition of heart failure seems to be straightforward, its diagnosis is not always easy to make. Many heart failure symptoms are nonspecific or even vague and therefore, of limited diagnostic value [bib_ref] Diagnosis of heart failure in primary care, Fonseca [/bib_ref] [bib_ref] The diagnostic value of physical examination and additional testing in primary care..., Kelder [/bib_ref]. Heart failure can be caused by the abnormal function of the myocardium, valves, and/or pericardium and even their combinations, but the exact etiology cannot be clearly differentiated with only history taking and/or physical examination [bib_ref] Diagnosis of heart failure in primary care, Fonseca [/bib_ref] [bib_ref] The diagnostic value of physical examination and additional testing in primary care..., Kelder [/bib_ref]. Also, the majority of heart failure patients become symptomatic with the development of myocardial dysfunction, which can be observed with a diverse spectrum of clinical states. Myocardial dysfunction can range from severely decreased ventricular systolic dysfunction with or without ventricular dilation to preserved ventricular systolic function (as assessed by ejection fraction) with normal ventricular size, both of which are 2 important types of heart failure, that is heart failure with reduced ejection fraction and heart failure with preserved ejection fraction, respectively [bib_ref] ESC Guidelines for the diagnosis and treatment of acute and chronic heart..., Mcmurray [/bib_ref]. Thus, assessment of the systolic as well as the diastolic function of the ventricle plays a central role in the diagnostic process of heart failure. Echocardiography is a well-known and established technique for assessing anatomical structure and function (systolic and diastolic) of the ventricle and this is one of the important reasons why echocardiography has taken a main position in the evaluation of heart failure. In fact, echocardiography has been widely employed to assess changes in ventricular size or volume, shape and function in many clinical trials [bib_ref] Role of cardiovascular magnetic resonance as a gatekeeper to invasive coronary angiography..., Assomull [/bib_ref] [bib_ref] Comparison of left ventricular ejection fraction and volumes in heart failure by..., Bellenger [/bib_ref] [bib_ref] Carvedilol produces dose-related improvements in left ventricular function and survival in subjects..., Bristow [/bib_ref] [bib_ref] Beta-blockade therapy in chronic heart failure: diastolic function and mitral regurgitation improvement..., Capomolla [/bib_ref] [bib_ref] Effects of carvedilol on left ventricular remodeling after acute myocardial infarction: the..., Doughty [/bib_ref]. In this respect, there is no doubt that echocardiography is the first-line imaging Korean J Radiol 15(6), Nov/Dec 2014 kjronline.org modality for the evaluation of heart failure patients. Nevertheless, echocardiography suffers from a wide interobserver variation in measurements of size and function, and furthermore, is vulnerable to image quality that is variable from patient to patient [bib_ref] Comparison of left ventricular ejection fraction and volumes in heart failure by..., Bellenger [/bib_ref]. In comparison, the image quality of CMR is not a main concern for analysis, and due to its inherent characteristics, post-processing does not require any geometric assumptions for ventricular volume quantification [bib_ref] Assessment of ventricular function and mass by cardiac magnetic resonance imaging, Alfakih [/bib_ref]. This is of particular importance in the evaluation of heart failure patients, given that many heart failure patients experience geometric changes in their ventricles with a large regional variation in contractility, which can predispose to errors in measurements of volume and ejection fraction by echocardiography. In addition, due to its high accuracy and reproducibility, CMR is believed to be the best reference standard imaging modality for the noninvasive, in vivo assessment of ventricular volume, mass, and function [bib_ref] Assessment of ventricular function and mass by cardiac magnetic resonance imaging, Alfakih [/bib_ref] [bib_ref] Detection and quantification of dysfunctional myocardium by magnetic resonance imaging. A new..., Holman [/bib_ref] [bib_ref] Interstudy reproducibility of right ventricular volumes, function, and mass with cardiovascular magnetic..., Grothues [/bib_ref] [bib_ref] Comparison of interstudy reproducibility of cardiovascular magnetic resonance with two-dimensional echocardiography in..., Grothues [/bib_ref] [bib_ref] Left ventricular volume measurement with echocardiography: a comparison of left ventricular opacification,..., Jenkins [/bib_ref]. CMR also allows for accurate, serial, longitudinal assessment of changes in ventricular size and function after therapeutic interventions on an individual patient basis. Therefore, sample sizes for any study can be far reduced with the use of CMR rather than echocardiography in the longitudinal assessment of ventricular volumes, mass and function [bib_ref] Reduction in sample size for studies of remodeling in heart failure by..., Bellenger [/bib_ref].
Identification of heart failure etiology should be a fundamental question addressed before a final decision is reached on therapeutic plans. Although structure and function are the two main targets for heart failure imaging, CMR can provide clues to underling abnormalities leading to heart failure [bib_ref] The role of cardiac MR in new-onset heart failure, Kim [/bib_ref] [bib_ref] Late gadolinium enhancement-cardiovascular magnetic resonance identifies coronary artery disease as the aetiology..., Valle-Munoz [/bib_ref]. CMR is highly accurate and reproducible in ventricular volume and ejection fraction measurements, as commented above. On top of that, myocardial perfusion, viability, and fibrosis imaging (using the LGE technique) by CMR can help identify heart failure etiology and predict prognosis [bib_ref] Late gadolinium enhancement-cardiovascular magnetic resonance identifies coronary artery disease as the aetiology..., Valle-Munoz [/bib_ref] [bib_ref] CT angiography with cardiac MRI: noninvasive functional and anatomical assessment for the..., Hamilton-Craig [/bib_ref]. In addition, LV mass quantification by CMR predicts prognosis in heart failure patients [bib_ref] The relationship of left ventricular mass and geometry to incident cardiovascular events:..., Bluemke [/bib_ref] [bib_ref] Assessment and significance of left ventricular mass by cardiovascular magnetic resonance in..., Olivotto [/bib_ref]. Among a variety of CMR techniques, LGE CMR provides a non-invasive imaging approach to determine the underlying etiology of heart failure by allowing for a direct interrogation of the myopathic process [bib_ref] The role of cardiac MR in new-onset heart failure, Kim [/bib_ref]. Differentiation between ischemic and non-ischemic etiology is a basic step for heart failure assessment because this classification exerts a significant effect on patient management decision and patient prognosis [bib_ref] kjronline.org response to drug treatment in heart failure, Follath [/bib_ref]. LGE CMR can help, in many cases, differentiation of the 2 conditions based on the LGE pattern. Ischemic LGE pattern is characterized by a 100% involvement of the subendocardium, i.e., subendocardial or transmural, and should be found in a region consistent with a perfusion territory of an epicardial coronary artery [bib_ref] Delayed enhancement cardiovascular magnetic resonance assessment of non-ischaemic cardiomyopathies, Mahrholdt [/bib_ref]. In contrast, a non-ischemic LGE pattern usually spares the subendocardium, i.e., mid-wall or epicardial, and/or is inconsistent with a perfusion territory subtended by one coronary artery [bib_ref] Delayed enhancement cardiovascular magnetic resonance assessment of non-ischaemic cardiomyopathies, Mahrholdt [/bib_ref]. LGE CMR is also helpful for the diagnosis of any specific type of non-ischemic cardiomyopathy causing heart failure, which can be finally achieved by analyzing the location and pattern of LGE. For example, asymmetric septal hypertrophic cardiomyopathy (HCM) is characterized by LGE of both junctions of the right ventricular (RV) and interventricular septum in the midwall [bib_ref] Myocardial scarring in asymptomatic or mildly symptomatic patients with hypertrophic cardiomyopathy, Choudhury [/bib_ref] , whereas apical LGE is frequently found in apical HCM [bib_ref] Myocardial scarring on cardiovascular magnetic resonance in asymptomatic or minimally symptomatic patients..., Kim [/bib_ref]. Mid-wall and epicardial LGE in the inferolateral segments can be found in patients with Anderson-Fabry disease (127), whereas LGE found in cardiac sarcoidosis can be variable. But subepicardial or midwall involvement, especially in basal septum, is unique findings of cardiac sarcoidosis (25). Cardiac amyloidosis has a typical LGE pattern, i.e., subendocardial, diffuse ring enhancement, with difficulty in determining optimal inversion time to null normal myocardium due to of its characteristic diffuse myocardial involvement [bib_ref] Cardiovascular magnetic resonance in cardiac amyloidosis, Maceira [/bib_ref]. Myocarditis can be diagnosed with LGE CMR and T2 edema imaging [bib_ref] Cardiovascular magnetic resonance assessment of human myocarditis: a comparison to histology and..., Mahrholdt [/bib_ref] [bib_ref] Contrast media-enhanced magnetic resonance imaging visualizes myocardial changes in the course of..., Friedrich [/bib_ref].
Assessment of transmurality of LGE is a good surrogate marker for prognosis prediction [bib_ref] Cardiovascular magnetic resonance assessment of human myocarditis: a comparison to histology and..., Mahrholdt [/bib_ref]. Combined CMR assessment of LGE extent and CMR-based LV ejection fraction is reported to be of prognostic value in heart failure patients [bib_ref] Prognostic value of routine cardiac magnetic resonance assessment of left ventricular ejection..., Klem [/bib_ref].
Approximately 50% of deaths in heart failure patients occur suddenly and unexpectedly. Thus, prevention of these unexpected events is another important target for heart failure management. Implantable cardioverter-defibrillator (ICD) therapy is a life-saving strategy in heart failure patients with severely decreased LV ejection fraction. Recent studies showed that assessment of myocardial scarring by LGE CMR can improve risk stratification in heart failure patients who are considered potential candidates for ICD therapy [bib_ref] Assessment of myocardial scarring improves risk stratification in patients evaluated for cardiac..., Klem [/bib_ref] [bib_ref] Potential clinical impact of cardiovascular magnetic resonance assessment of ejection fraction on..., Joshi [/bib_ref]. also demonstrated that assessment of the total scar by LGE CMR can predict an arrhythmic event. Despite no CMR criteria suggested by the heart failure guideline published in 2012 (104), CMRbased ICD therapy seems to hold promise in the prediction of patients who may benefit from ICD therapy. The same strategy can be true for determining potential candidates of cardiac resynchronization therapy (CRT) or for planning Korean J Radiol 15(6), Nov/Dec 2014 kjronline.org CRT procedures [bib_ref] Relative merits of left ventricular dyssynchrony, left ventricular lead position, and myocardial..., Delgado [/bib_ref] [bib_ref] Current and future role of cardiovascular magnetic resonance in cardiac resynchronization therapy, Leyva [/bib_ref] [bib_ref] Cardiac resynchronization therapy guided by late gadolinium-enhancement cardiovascular magnetic resonance, Leyva [/bib_ref] , but this has yet to be confirmed with more data.
Although some case series have reported the safety and effectiveness of the CMR-based approach in heart failure patients with ICD [bib_ref] MRI-Guided ventricular tachycardia ablation: integration of late gadolinium-enhanced 3D scar in patients..., Dickfeld [/bib_ref] [bib_ref] Safety of serial MRI in patients with implantable cardioverter defibrillators, Junttila [/bib_ref] , this is not generally accepted in the current era, and great care should be exercised before it is adopted into daily clinical practice. Generally, CMR is not recommended in patients with ICD or CRT devices.

## Evaluation in patients with risk of heart failure or overt heart failure (general) (protocols may include lv/rv mass and volumes, mr angiography, quantification of valvular disease, and lge evaluation)
1. Evaluation of LV function following myocardial infarction OR in heart failure patients (Level of evidence: A, Appropriateness criteria: A) 2. Evaluation of LV function following myocardial infarction OR in heart failure patients/patients with technically limited images from echocardiogram (Level of evidence: A, Appropriateness criteria: A) 3. Quantification of LV function/discordant information that is clinically significant from prior tests (Level of evidence: A, Appropriateness criteria: A) 4. Evaluation in patients with new onset heart failure to assess etiology (Level of evidence: A, Appropriateness criteria: A) 5. Initial evaluation of structure and function for newly suspected or potential heart failure (also including malignancy on current or planned cardiotoxic therapy, survived patients with suspected ventricular dysfunction after chemotherapy, and no prior imaging evaluation/familial or genetic cardiomyopathy in first-degree relative, known congenital heart disease with suspected ventricular dysfunction, acute myocardial infarction during initial hospitalization) (Level of evidence: A, Appropriateness criteria: A) 6. Evaluation to determine patient candidacy of ICD therapy (ejection fraction and/or other structural information) (Level of evidence: A, Appropriateness criteria: A) 7. Initial evaluation to determine patient candidacy of CRT or procedural planning (ejection fraction, fibrosis, scarring, coronary vein variation, and intracavitary thrombus) (Level of evidence: A, Appropriateness criteria: A) 8. Cardiac function follow-up after ICD or CRT (Level of evidence: C, Appropriateness criteria: I)

## Clinical scenario 11: patients with congenital heart disease
Cardiac magnetic resonance is very useful in the evaluation of congenital heart disease because complete contiguous data sets from cardiac base to apex can give complete descriptions of cardiac and extra-cardiac anatomy of both simple and complex congenital heart disease very effectively. Unlike cardiac CT, ionizing radiation exposure is not an issue for CMR, allowing for repeated or sequential evaluation of children and young adults without radiation concern. Nevertheless, CMR is limited in criticallyill patients, especially in acute settings or in patients who cannot cooperate with the medical team, especially neonates and infants. Therefore, CMR is in most cases used as an adjunct approach to echocardiography. Thus, review of echocardiographic images can aid in the appropriate selection of CMR sequences that are likely to give answers to unresolved questions. Although CMR is less operatordependent when compared to echocardiography, a thorough understanding of the anatomical and functional aspects of any given congenital heart disease is absolutely necessary for a complete interrogation of that particular congenital heart disease patient. A comprehensive evaluation of cardiac and extra-cardiac anatomic structures can be imaged as well, which makes CMR clinically useful in complex congenital heart disease patients.

## Anomalies of coronary circulation
Although CT coronary angiography offers much clearer anatomical information, the origin and proximal course of the coronary arteries can still be relatively well investigated by MR coronary angiography (45). For patients who have difficulty in holding their breath, real-time coronary imaging using diaphragm navigators can be used to minimize image blurring (42). MR coronary angiography is also useful in the identification of inflammatory changes in the coronary artery, such as changes that would occur with Kawasaki disease [bib_ref] Coronary magnetic resonance angiography in adolescents and young adults with kawasaki disease, Greil [/bib_ref].

## Anomalies of great vessels (anomalies of aorta and pulmonary artery)
MR angiography is also very effective for a complete evaluation of the great vessels. Coarctation of the aorta is Korean J Radiol 15(6), Nov/Dec 2014 kjronline.org one representative disease. Transthoracic echocardiography using the 2D and Doppler technique is in many cases enough to diagnose and evaluate hemodynamic severity, but some difficulties can be encountered. Under these situations, CMR can provide diverse and extensive information regarding the severity and extent of stenosis, collateral circulation, and morphologic changes in the ascending aorta, and associated anomalies in the aortic valve. CMR is also a good imaging modality after surgical correction or angioplasty [bib_ref] Results and mid-long-term follow-up of stent implantation for native and recurrent coarctation..., Chessa [/bib_ref] [bib_ref] Long-term effects of balloon angioplasty on left ventricular hypertrophy in adolescent and..., Hassan [/bib_ref] [bib_ref] Follow-up of patients with previous treatment for coarctation of the thoracic aorta:..., Bogaert [/bib_ref]. Contrast-enhanced 3D MR angiography can show abnormal sources of pulmonary blood supply from the major aorta associated with pulmonary stenosis or atresia, though CT angiography is more sensitive at detecting small vessels connected to the pulmonary vessels [bib_ref] Gadolinium-enhanced 3-dimensional magnetic resonance angiography of pulmonary blood supply in patients with..., Geva [/bib_ref] [bib_ref] Role of magnetic resonance angiography in the diagnosis of major aortopulmonary collateral..., Prasad [/bib_ref].
Due to the ability of CMR to reliably assess the entire aorta and its major branches, aortic disease accompanied by systemic diseases like Marfan syndrome or Ehler-Danlos syndrome can be accurately investigated. In addition, CMR can detect in the preclinical stage abnormal aortic elastic properties in affected patients before aortic dilation clinically manifests [bib_ref] Magnetic resonance imaging evaluation of aortic elastic properties as early expression of..., Fattori [/bib_ref] [bib_ref] Diagnostic power of aortic elastic properties in young patients with Marfan syndrome, Baumgartner [/bib_ref].

## Assessment of cardiac chambers and valves
Cardiac magnetic resonance is an excellent technique for defining the morphologic features of ventricles [bib_ref] Role of spin echo and cine magnetic resonance imaging in presurgical planning..., Geva [/bib_ref]. Thus, it is easy to determine which ventricle the morphological RV is and which ventricle the morphological LV is with comprehensive CMR assessment. For this purpose, detailed knowledge of the LV and RV is a prerequisite; the morphological RV is characterized by multiple coarse trabeculations including the moderator band, and is always connected to the tricuspid valve that is located more apically without exception in relation to the mitral valve. Thus, complex congenital heart disease like transposition of the great arteries or congenitally corrected transposition of the great arteries can be accurately assessed [bib_ref] kjronline.org in patients with transposition of the great arteries using the myocardial..., Salehian [/bib_ref] [bib_ref] Transposition of the great arteries, Warnes [/bib_ref]. In addition, CMR is also very valuable in terms of postoperative follow-up of these patients [bib_ref] Transposition of the great arteries, Warnes [/bib_ref] [bib_ref] Outcome of 121 patients with congenitally corrected transposition of the great arteries, Rutledge [/bib_ref]. CMR can easily detect the presence of an intra-cardiac shunt like a ventricular septal defect (VSD) or atrial septal defect (ASD) with jets localization and shunt quantification [bib_ref] Identification and localization of ventricular septal defect by gated magnetic resonance imaging, Didier [/bib_ref] [bib_ref] Assessment of left-to-right intracardiac shunting by velocity-encoded, phase-difference magnetic resonance imaging. A..., Hundley [/bib_ref] [bib_ref] Flow volume and shunt quantification in pediatric congenital heart disease by real-time..., Korperich [/bib_ref] [bib_ref] Rapid left-to-right shunt quantification in children by phase-contrast magnetic resonance imaging combined..., Beerbaum [/bib_ref].
It is in no doubt that echocardiography is the first line of investigation for patients with valve diseases including congenital valve lesions. However, CMR can provide additional information to that offered by echocardiography, especially in patients with poor echocardiographic windows and patients with right-sided valve diseases. Thanks to its high spatial resolution and signal-to-noise ratio, morphologic or pathological changes in cardiac valves of interest can be assessed. In addition, phase contrast imaging allows for the accurate quantification of regurgitant volume. This can be specifically applied to patients with significant pulmonary regurgitation. The ability of CMR to quantitate regurgitant volume is particularly valuable for the sequential monitoring of pulmonary regurgitation severity in patients with tetralogy of Fallot who have undergone RV outflow tract patch surgery [bib_ref] Pulmonary regurgitation in the late postoperative follow-up of tetralogy of Fallot. Volumetric..., Rebergen [/bib_ref]. Sequential evaluation of regurgitant volume along with RV volume changes can help decide the optimal timing of pulmonary valve replacement [bib_ref] Optimal timing for pulmonary valve replacement in adults after tetralogy of Fallot..., Therrien [/bib_ref] [bib_ref] Preoperative thresholds for pulmonary valve replacement in patients with corrected tetralogy of..., Oosterhof [/bib_ref]. LGE CMR may contribute to risk stratification, as well [bib_ref] Ventricular fibrosis suggested by cardiovascular magnetic resonance in adults with repaired tetralogy..., Babu-Narayan [/bib_ref]. However, in patients with a repaired tetralogy of Fallot, other factors should be assessed including tricuspid regurgitation, any residual VSD, branch pulmonary stenosis, aortic regurgitation and LV dysfunction. Therefore, a thorough evaluation of the left-and rightsided ventricles and valves with an extension to branch pulmonary arteries and the ascending aorta should be made to manage patients with a repaired tetralogy of Fallot. Another important disease for which CMR can make great contributions to assessment is the Ebstein anomaly and the associated tricuspid regurgitation [bib_ref] Prospective comparison of echocardiography versus cardiac magnetic resonance imaging in patients with..., Jost [/bib_ref]. Obtaining a stack of trans-axial cines is recommended, as well as horizontal four-chamber cines for complete visualization of the relationship between the right atrium and RV in patients with the Ebstein anomaly. A combination of these cine images is necessary for accurate and reproducible volume measurements of the functional RV in these patients, which is not easy to perform using short-axis cines [bib_ref] Cardiac magnetic resonance imaging and the assessment of ebstein anomaly in adults, Yalonetsky [/bib_ref]. Tricuspid regurgitation is frequently accompanied and the quantification of its severity using phase contrast imaging is also an important integrated part of CMR evaluation in these patients. An ASD or patent foramen ovale is present in up to 50% of patients and should be sought with an atrial short-axis cine stack, although echocardiography is preferable to CMR for this purpose. Shunt volume can be quantified by phase-contrast imaging.

## Postoperative follow-up of congenital heart disease patients
Echocardiography is usually employed for the serial monitoring of congenital heart disease patients after surgery or the trans-catheter technique. In most cases, echocardiography is more than adequate, but in some cases, Korean J Radiol 15(6), Nov/Dec 2014 kjronline.org accurate RV/LV volumes or regurgitant volume quantification is clinically important in deciding the optimal management. CMR can provide more accurate and reproducible ventricular volumes and function measurements than echocardiography [bib_ref] Interstudy reproducibility of right ventricular volumes, function, and mass with cardiovascular magnetic..., Grothues [/bib_ref] [bib_ref] Right ventricular function in grown-up patients after correction of congenital right heart..., Lemmer [/bib_ref]. This is especially true for the RV [bib_ref] Evaluation of postoperative pulmonary regurgitation after surgical repair of tetralogy of Fallot:..., Grothoff [/bib_ref] [bib_ref] Exercise MR imaging in the assessment of pulmonary regurgitation and biventricular function..., Roest [/bib_ref] , which is frequently involved and stressed by the repair of CHD [bib_ref] Exercise MR imaging in the assessment of pulmonary regurgitation and biventricular function..., Roest [/bib_ref]. The sequential evaluation of pulmonary regurgitation and its effects on LV and RV functions should be comprehensively evaluated by CMR for effective patient management [bib_ref] Cardiovascular magnetic resonance in the follow-up of patients with corrected tetralogy of..., Oosterhof [/bib_ref] [bib_ref] Corrected tetralogy of Fallot: delayed enhancement in right ventricular outflow tract, Oosterhof [/bib_ref] [bib_ref] Right ventricular function in adults with repaired tetralogy of Fallot assessed with..., Davlouros [/bib_ref]. The same strategy can be applied to patients with transposition of the great arteries who have undergone atrial and arterial switch operations, and patients with Fontan operations [bib_ref] Transposition of the great arteries, Warnes [/bib_ref] [bib_ref] MR coronary angiography and lateenhancement myocardial MR in children who underwent arterial..., Taylor [/bib_ref] [bib_ref] Effects of metallic implants on magnetic resonance imaging evaluation of Fontan palliation, Garg [/bib_ref] [bib_ref] Aortopulmonary collaterals after bidirectional cavopulmonary connection or Fontan completion: quantification with MRI, Grosse-Wortmann [/bib_ref] [bib_ref] Late ventricular geometry and performance changes Korean, Fogel [/bib_ref].

## In congenital heart disease (protocols may include lv/rv mass and volumes, mr angiography, quantification of valvular disease, and lge evaluation)
1. Assessment about structure and hemodynamics of congenital heart disease including anomalies of coronary circulation, great vessels, and cardiac chambers and valves (Level of evidence: A, Appropriateness criteria: A) 2. Assessment of post-operative structure and hemodynamics of congenital heart disease including ventricular, great arterial and valvular function and anatomy evaluation (Level of evidence: A, Appropriateness criteria: A)

## Clinical scenario 12: patients with valvular heart disease
Direct visualization of valvular anatomy and the cardiac chambers, and its hemodynamic consequences have been possible since the advent of 2D and Doppler echocardiography. There has been no doubt at all that echocardiography is the standard tool for the initial assessment and longitudinal follow-up of patients with valvular heart disease irrespective of native or prosthetic valves. Therefore, the role of CMR is strictly limited in the field of valvular heart disease in daily clinical practice. However, over the last 20 years, CMR has made remarkable improvements in its image quality, scan time, and even hemodynamic assessment and, as a result, it has emerged as an alternative noninvasive imaging modality that is without ionizing radiation exposure in patients with valvular diseases. Thanks to its excellent signal-to-noise ratio and good spatial resolution, CMR can provide beautiful images of the valve anatomy and can thus also provide valuable insight into the mechanisms of valvular lesions. Regurgitant or stenotic flow jets are well visualized on cine imaging without any contrast agent. However, jet size or density should not be used for qualitative evaluation of the severity of valvular disease. The visibility extent of any jet observed in cine CMR imaging does depend on the CMR setting of specific sequences. While CMR can quantify the severity of stenotic or regurgitant valve lesions via the phase contrast imaging technique, velocities can be underestimated if the scan slice is not optimally aligned to regurgitant or stenotic jets. In the evaluation of patients with valvular disease, the advantage of CMR is in its power to reveal consequences of the valvular lesion, including the effects on LV or RV volumes, systolic function and left atrial or right atrial volumes. More fascinating is the fact that all of these examinations can be performed without administration of contrast agents, and thus can be conducted in patients with renal failure without fear of nephrogenic systemic fibrosis. The SSFP cine pulse sequence is the most widely used CMR technique for investigating valve anatomy and motion. This pulse sequence is well known to have excellent blood-to-myocardium contrast and a high intrinsic signalto-noise ratio [bib_ref] Cardiovascular magnetic resonance imaging for valvular heart disease: technique and validation, Cawley [/bib_ref]. With this technique, CMR can create tomographic images at any plane and at any level. Phase contrast imaging is used for velocity measurements and can be considered in patients whose echocardiographic images are inconclusive or inadequate for reliable evaluation. However, because temporal resolution of phase contrast imaging is much lower than Doppler echocardiography, we should consider a chance that the peak velocity will be underestimated.
One thing that should be kept in mind is that almost all CMR validation studies in relation to valvular heart disease were performed with echocardiography as the gold standard and only in a small number of patients [bib_ref] Valve area and cardiac output in aortic stenosis: quantification by magnetic resonance..., Sndergaard [/bib_ref] [bib_ref] Practical value of cardiac magnetic resonance imaging for clinical quantification of aortic..., Caruthers [/bib_ref] [bib_ref] Planimetry of mitral valve stenosis by magnetic resonance imaging, Djavidani [/bib_ref] [bib_ref] Aortic regurgitation: quantitation with MR imaging velocity mapping, Honda [/bib_ref] [bib_ref] Evaluation of aortic regurgitation in congenital heart disease: value of MR imaging..., Ley [/bib_ref] [bib_ref] Quantification of regurgitant fraction in mitral regurgitation by cardiovascular magnetic resonance: comparison..., Kon [/bib_ref] [bib_ref] Prospective comparison of valve regurgitation quantitation by cardiac magnetic resonance imaging and..., Cawley [/bib_ref]. Nevertheless, the peak antegrade velocity, pressure gradient, and stenotic valve area can be accurately calculated with CMR in patients with valve stenosis. In addition, the regurgitant valve area, regurgitant volume and regurgitant fraction can be assessed in patients with valvular regurgitation. Like Doppler echocardiography, however, a misalignment of more than 20 degrees between the phase direction and the blood flow direction makes velocity measurements with CMR inaccurate [bib_ref] Prospective comparison of valve regurgitation quantitation by cardiac magnetic resonance imaging and..., Cawley [/bib_ref]. Reproducibility of LV and RV volume quantification is one of the most important strengths of CMR. Any significant Korean J Radiol 15(6), Nov/Dec 2014 kjronline.org valvular regurgitation can cause LV or RV volume overload and can finally precipitate the LV or RV to remodel and change geometry. LV and RV volumes can be accurately measured with CMR without any assumption of ventricular geometry. This is especially useful for right-sided valve regurgitation, because echocardiography cannot accurately assess RV volume and ejection fraction due to its complex geometry and shape. In particular, pulmonary regurgitation, a major late complication after surgical correction of tetralogy of Fallot, has been frequently assessed using CMRbased RV volume measurements [bib_ref] Pulmonary regurgitation in the late postoperative follow-up of tetralogy of Fallot. Volumetric..., Rebergen [/bib_ref] [bib_ref] Evaluation of postoperative pulmonary regurgitation after surgical repair of tetralogy of Fallot:..., Grothoff [/bib_ref] [bib_ref] Outcomes of pulmonary valve replacement in 170 patients with chronic pulmonary regurgitation..., Lee [/bib_ref] [bib_ref] Impact of gender and age on cardiovascular function late after repair of..., Sarikouch [/bib_ref] and now CMR is generally accepted as the gold standard method for in vivo RV assessment [bib_ref] Quantifying pulmonary regurgitation and right ventricular function in surgically repaired tetralogy of..., Mercer-Rosa [/bib_ref] [bib_ref] Evaluation of right ventricular function in patients with tetralogy of Fallot using..., Koca [/bib_ref]. Also, although CMR is safe in patients with prosthetic valves at 1.5-T, the metal contained within prosthetic valves generates artifacts and signal loss, and thus CMR validation in patients with prosthetic valves is very limited [bib_ref] Assessment of prosthetic aortic valve performance by magnetic resonance velocity imaging, Botnar [/bib_ref] [bib_ref] Heart motion-adapted MR velocity mapping of blood velocity distribution downstream of aortic..., Kozerke [/bib_ref] [bib_ref] Feasibility of cardiovascular magnetic resonance to assess the orifice area of aortic..., Von Knobelsdorff-Brenkenhoff [/bib_ref]. Thus, as of now, the clinical use of CMR in valvular heart disease is limited. In this respect, the use of CMR in valve diseases is currently recommended only for patients with technically challenging echocardiographic images.

## In valvular heart disease (protocols may include lv/ rv mass and volumes, mr angiography, quantification of valvular disease, and lge evaluation)
1. Characterization of native and prosthetic cardiac valves-including planimetry of stenotic disease and quantification of regurgitant disease/patients with technically limited images from transthoracic or transesophageal echocardiography (Level of evidence: A, Appropriateness criteria: A)

## Clinical scenario 13: patients with suspected or diagnosed myocardial disease
Myocardial diseases are one of the most important disease entities in the field of cardiology. They are usually classified into 2 categories, namely cardiomyopathy and myocarditis.

## Cardiomyopathy
Cardiomyopathy is classified into 5 different categories, although there are definitely situations in which the suggested classification system cannot fully address some of the myopathic phenotypes. Unlike HCM and dilated cardiomyopathy (DCM), arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is diagnosed on a histologic basis and characterized by progressive fibrofatty replacement in the RV, resulting in morphological and functional changes of the RV. ARVD/C can sometimes involve the LV and clinically manifests as a DCM phenotype, but this is not always true.
Recently, the role of CMR has been significantly increased in the diagnosis of ARVD/C. Generally, the diagnosis of ARVD/C depends on the demonstration of structural, functional, ECG abnormalities, and their combinations. According to the original task force criteria, RV morphological and functional abnormalities were predominantly estimated by echocardiography. However, though useful, echocardiography is not the best approach for assessing morphological and functional changes in the RV. CMR is the gold standard for this purpose and thus, the revised task force criteria encompassed the CMR-derived definition of RV morphological and functional abnormalities including RV regional wall motion abnormalities, correct quantification of RV volumes, aneurysm/trabecular disarray, and increased myocardial signal suggestive of fatty replacement [bib_ref] Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the Task Force..., Marcus [/bib_ref]. However, the role of LGE CMR has not been mentioned in this new proposed criteria [bib_ref] Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the Task Force..., Marcus [/bib_ref]. CMR can allow for early detection of patients with genotype (+), but with phenotype (-) [bib_ref] Cardiovascular magnetic resonance in arrhythmogenic right ventricular cardiomyopathy revisited: comparison with task..., Sen-Chowdhry [/bib_ref]. In addition to its diagnostic role, CMR including LGE imaging can play a prognostic role in ARVD/C patients [bib_ref] Arrhythmogenic right ventricular cardiomyopathy: diagnostic and prognostic value of the cardiac MRI..., Keller [/bib_ref] [bib_ref] Noninvasive detection of myocardial fibrosis in arrhythmogenic right ventricular cardiomyopathy using delayed-enhancement..., Tandri [/bib_ref]. However, given that the normal variants of the RV are usually greater than those found in the LV, great caution should be exercised in the interpretation of RV findings found in CMR.
As described in the heart failure section, CMR can be very helpful in the differential diagnosis or evaluation of specific cardiomyopathies, especially thanks to the advent of LGE imaging. Aside from ischemia-induced myocardial disease, the LGE pattern of non-ischemic cardiomyopathies usually spares the subendocardium, i.e., mid-wall or epicardial, and/or is inconsistent with a perfusion territory subtended by one coronary artery [bib_ref] Delayed enhancement cardiovascular magnetic resonance assessment of non-ischaemic cardiomyopathies, Mahrholdt [/bib_ref]. The LGE pattern depends on the type of cardiomyopathy, though it is not always or totally differential [bib_ref] Delayed enhancement cardiovascular magnetic resonance assessment of non-ischaemic cardiomyopathies, Mahrholdt [/bib_ref]. For example, it has been reported that cardiac amyloidosis has a typical LGE pattern, i.e., subendocardial, diffuse ring enhancement, with difficulty in determining optimal inversion time to null normal myocardium due to its characteristic diffuse involvement [bib_ref] Cardiovascular magnetic resonance in cardiac amyloidosis, Maceira [/bib_ref] [bib_ref] Late enhancement in cardiac amyloidosis: correlation of MRI enhancement pattern with histopathological..., Hosch [/bib_ref] , although the precise pattern of LGE in cardiac amyloidosis has been reported to be more variable in recent studies than what was previously believed [bib_ref] Cardiovascular magnetic resonance in clinically suspected cardiac amyloidosis: noninvasive imaging compared to..., Vogelsberg [/bib_ref] [bib_ref] Role of cardiac magnetic resonance imaging in the detection of cardiac amyloidosis, Syed [/bib_ref]. However, LGE CMR is expected to facilitate the easy detection of cardiac involvement in Korean J Radiol 15(6), Nov/Dec 2014 kjronline.org patients with sarcoidosis, and to be used in monitoring treatment responses because the degree of LGE is reduced with successful treatment of steroid therapy, suggesting the possibility that it may be used as a therapeutic surrogate marker [bib_ref] Diagnosis of cardiac sarcoidosis and evaluation of the effects of steroid therapy..., Shimada [/bib_ref]. Trastuzumab-induced cardiomyopathy is characterized by LGE of the lateral wall of the LV within the mid myocardial portion [bib_ref] The utility of cardiac biomarkers, tissue velocity and strain imaging, and cardiac..., Fallah-Rad [/bib_ref] , but this finding requires further data. LV noncompaction cardiomyopathy has been increasingly recognized along with the revolutionary evolution of cardiac imaging techniques. LV noncompaction cardiomyopathy is characterized by 2 factors; prominent LV trabeculae and deep inter-trabecular recesses [bib_ref] Long-term follow-up of 34 adults with isolated left ventricular noncompaction: a distinct..., Oechslin [/bib_ref]. Since this cardiomyopathy can be diagnosed by LV morphologic features, the role of CMR has been increasingly important with its unprecedented high signal-to-noise ratio. A ratio of noncompacted/compacted myocardium of more than 2.3 in diastole was suggested for the CMR diagnosis of this disease entity [bib_ref] Left ventricular noncompaction: insights from cardiovascular magnetic resonance imaging, Petersen [/bib_ref]. CMR also precisely interrogates the transition zone between affected and non-affected LV segments due to its good spatial resolution. Stressinduced cardiomyopathy was recently incorporated into cardiomyopathy classification, which is usually characterized by transient regional LV systolic dysfunction in the absence of obstructive epicardial coronary disease on coronary angiography. In most cases, the LV apex is involved, but sometimes the mid-ventricle or basal ventricle alone can be affected. Although echocardiography is usually enough for the diagnosis of stress-induced cardiomyopathy, CMR seems to be a promising imaging modality for confirming regional wall motion abnormality and for differentiating this (no LGE is present in most cases) from acute myocardial infarction or myocarditis (LGE is frequently present) based on the presence or absence of LGE [bib_ref] Acute and reversible cardiomyopathy provoked by stress in women from the United..., Sharkey [/bib_ref] [bib_ref] Cardiovascular magnetic resonance findings in typical versus atypical forms of the acute..., Haghi [/bib_ref] [bib_ref] Clinical features and usefulness of cardiac magnetic resonance imaging in assessing myocardial..., Mitchell [/bib_ref].

## Myocarditis
Myocarditis is another important myocardial disease of which a diagnosis is not easy to make. The gold standard method of diagnosis is histologic confirmation of myocardial inflammation, which is sometimes difficult and limited by the patchy involvement of the inflammatory process. Myocardial biopsy carries some risk, as well. The unique ability of CMR to visualize myocardial tissue changes is the reason for CMR being increasingly employed in the diagnostic process of myocarditis [bib_ref] Acute myocarditis presenting as acute coronary syndrome: role of early cardiac magnetic..., Monney [/bib_ref] [bib_ref] Diagnosis of viral myocarditis by cardiac magnetic resonance and viral genome detection..., Jeserich [/bib_ref]. Anticipated tissue pathological changes in acute myocarditis include intracellular/interstitial edema, hyperemia, capillary leakage, and cellular necrosis with fibrosis, all of which can be easily found with a variety of CMR techniques like T2 edema imaging and LGE or the early enhancement technique. CMR can show increases in myocardial signals on T2-weighted and LGE images in acute myocarditis [bib_ref] Cardiovascular magnetic resonance assessment of human myocarditis: a comparison to histology and..., Mahrholdt [/bib_ref] [bib_ref] Contrast media-enhanced magnetic resonance imaging visualizes myocardial changes in the course of..., Friedrich [/bib_ref].
For the accurate diagnosis of cardiomyopathy etiology, the role of CMR is increasingly recognized and emphasized. There is no doubt that the gold standard method for etiological diagnosis is histological confirmation and the first-line imaging modality in patients under suspicion for myocardial disease is echocardiography. However, a comprehensive CMR protocol including cine, LGE, and sometimes perfusion techniques can provide etiological diagnosis and prognostic implications.

## In suspected or diagnosed myocardial disease (protocols may include lv/rv mass and volumes, mr angiography, quantification of valvular disease, and
LGE evaluation) [bib_ref] CCS/CAR/CANM/CNCS/CanSCMR joint position statement on advanced noninvasive cardiac imaging using positron emission..., Beanlands [/bib_ref] 

## Clinical scenario 14: evaluation in patients with hcm
Hypertrophic cardiomyopathy is the most common genetic cardiovascular disorder that is characterized by sarcomere gene mutation [bib_ref] The molecular genetic basis for hypertrophic cardiomyopathy, Marian [/bib_ref]. Accurate diagnosis of HCM is crucial because HCM patients must alter their life-style to prevent unexpected dismal events. Family screening should be done, as well. Transthoracic echocardiography is the most commonly used imaging modality for the diagnosis of HCM by identification of LV hypertrophy and systolic anterior motion of the mitral valve with associated LV outflow tract dynamic obstruction. CMR, thanks to its high signal-to-noise ratio and good spatial resolution, has established its role in the diagnosis of HCM, because phenotypic expressions of HCM are diverse and complex, Korean J Radiol 15(6), Nov/Dec 2014 kjronline.org and thus transthoracic echocardiography sometimes misses the hypertrophic segments, especially in the apex, posteroseptum and lateral free wall, difficult areas to evaluate with transthoracic echocardiography due to its low lateral spatial resolution [bib_ref] Utility of cardiac magnetic resonance imaging in the diagnosis of hypertrophic cardiomyopathy, Rickers [/bib_ref] [bib_ref] Management implications of massive left ventricular hypertrophy in hypertrophic cardiomyopathy significantly underestimated..., Maron [/bib_ref] [bib_ref] Detection of apical hypertrophic cardiomyopathy by cardiovascular magnetic resonance in patients with..., Moon [/bib_ref] [bib_ref] Hypertrophic cardiomyopathy phenotype revisited after 50 years with cardiovascular magnetic resonance, Maron [/bib_ref]. The LV apex is notably much more difficult to evaluate with echocardiography due in part to its proximity to the echocardiographic probe. Thus, diagnosis of apical HCM may be underreported using transthoracic echocardiography [bib_ref] Detection of apical hypertrophic cardiomyopathy by cardiovascular magnetic resonance in patients with..., Moon [/bib_ref]. In addition, the detection of apical aneurysm is problematic with transthoracic echocardiography. However, a more sensitive discovery of apical aneurysm in HCM is clinically relevant, given that its prevalence is not low and that its presence is associated with cardiovascular morbidity and mortality [bib_ref] Occurrence and frequency of arrhythmias in hypertrophic cardiomyopathy in relation to delayed..., Adabag [/bib_ref] [bib_ref] Clinical implications of midventricular obstruction in patients with hypertrophic cardiomyopathy, Minami [/bib_ref]. In this respect, cine CMR can provide more accurate information about the LV hypertrophic pattern and the presence or absence of apical aneurysm in HCM patients whose echocardiographic images are technically suboptimal and nondiagnostic. The phenotypic heterogeneity of HCM sometimes involves morphologic abnormalities of the RV, which can be assessed with cine CMR more accurately than with transthoracic echocardiography, although the clinical or prognostic significance of RV involvement in HCM is yet to be determined [bib_ref] Right ventricular involvement in hypertrophic cardiomyopathy, Maron [/bib_ref].
Late gadolinium enhancement CMR can provide a unique opportunity for patients with unexplained LV hypertrophy [bib_ref] Noninvasive detection of fibrosis applying contrastenhanced cardiac magnetic resonance in different forms..., Rudolph [/bib_ref]. LGE in HCM is predominantly located at the anterior and posterior insertion points of the RV into the septum with a typical non-subendocardial pattern [bib_ref] Noninvasive detection of fibrosis applying contrastenhanced cardiac magnetic resonance in different forms..., Rudolph [/bib_ref]. However, LGE can be found in different locations, not confined to hypertrophic segments [bib_ref] Myocardial scarring on cardiovascular magnetic resonance in asymptomatic or minimally symptomatic patients..., Kim [/bib_ref]. Myocardial fibrosis is generally accepted as the main pathohistological feature of HCM, which can be accurately assessed with LGE CMR [bib_ref] Myocardial fibrosis in hypertrophic cardiomyopathy: accurate reflection of histopathological findings by CMR, Moravsky [/bib_ref] [bib_ref] Evaluation of techniques for the quantification of myocardial scar of differing etiology..., Flett [/bib_ref] [bib_ref] The histologic basis of late gadolinium enhancement cardiovascular magnetic resonance in hypertrophic..., Moon [/bib_ref]. CMR-determined myocardial fibrosis has been repeatedly reported to be closely associated with a grave prognosis in HCM patients and has advantages over traditional risk factors for future sudden death [bib_ref] Occurrence and frequency of arrhythmias in hypertrophic cardiomyopathy in relation to delayed..., Adabag [/bib_ref] [bib_ref] Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy, O&apos;hanlon [/bib_ref] [bib_ref] Myocardial scar visualized by cardiovascular magnetic resonance imaging predicts major adverse events..., Bruder [/bib_ref] [bib_ref] Prognostic importance of late gadolinium enhancement cardiovascular magnetic resonance in cardiomyopathy, Ismail [/bib_ref] [bib_ref] Clinical profile and significance of delayed enhancement in hypertrophic cardiomyopathy, Maron [/bib_ref] [bib_ref] Characteristics and clinical significance of late gadolinium enhancement by contrast-enhanced magnetic resonance..., Rubinshtein [/bib_ref] [bib_ref] Prognostic value of late gadolinium enhancement in clinical outcomes for hypertrophic cardiomyopathy, Green [/bib_ref]. Also, the extent of LGE is reported to be linked to progressive ventricular remodeling [bib_ref] Toward clinical risk assessment in hypertrophic cardiomyopathy with gadolinium cardiovascular magnetic resonance, Moon [/bib_ref]. Given the strong association between the presence of LGE and ventricular tachyarrhythmia on Holter monitoring [bib_ref] Occurrence and frequency of arrhythmias in hypertrophic cardiomyopathy in relation to delayed..., Adabag [/bib_ref] [bib_ref] Characteristics and clinical significance of late gadolinium enhancement by contrast-enhanced magnetic resonance..., Rubinshtein [/bib_ref] [bib_ref] inducibility of ventricular tachyarrhythmia in hypertrophic cardiomyopathy, Fluechter [/bib_ref] , it is conceivable that LGE in HCM can be a potential arbitrator of ventricular tachyarrhythmia. Although LGE CMR looks promising, there still seems to be insufficient data for inserting ICDs in HCM patients based only on LGE CMR findings, given the technical and methodological issues of LGE assessment [bib_ref] Cardiac magnetic resonance in hypertrophic cardiomyopathy, To [/bib_ref].
Hypertrophic cardiomyopathy is a genetic disease with an autosomal dominant trait, and thus first-degree relatives have a 50% chance of being gene carriers. Although genotyping is the best way to detect possible future clinical manifestations of HCM, it is limited by high cost and the variable penetrance of the disease. Another problem is that approximately 40% of HCM patients are genetically negative. Therefore, the most realistic screening modalities that can be applied clinically are the ECG and echocardiogram. However, some CMR findings have recently been found to suggest early imaging manifestations of HCM including myocardial crypts [bib_ref] Structural abnormalities of the inferoseptal left ventricular wall detected by cardiac magnetic..., Germans [/bib_ref] [bib_ref] Prevalence and clinical profile of myocardial crypts in hypertrophic cardiomyopathy, Maron [/bib_ref] , elongated mitral valve leaflets [bib_ref] Mitral valve abnormalities identified by cardiovascular magnetic resonance represent a primary phenotypic..., Maron [/bib_ref] , and the presence of LGE suggesting HCM [bib_ref] CMR with late gadolinium enhancement in genotype positive-phenotype negative hypertrophic cardiomyopathy, Rowin [/bib_ref]. All of these findings should be confirmed in future CMR studies, but if combined with genetic testing, these CMR evaluations have the potential to identify HCM at an early stage of the disease. Current and emerging recommendations of CMR are summarized in the following

## Miscellaneous disease

## Clinical scenario 15: evaluation of cardiac mass (suspected tumor or thrombus)/use of contrast for perfusion and enhancement
Intracardiac mass is not uncommonly seen in clinical situations with the thrombus being the most common intracardiac mass. Notably, a left atrial thrombus in patients with atrial fibrillation and a LV thrombus in patients with severe LV systolic dysfunction due to myocardial infarction or underlying cardiomyopathy are frequently discovered. Several previous studies show that the detection rate of an intracardiac thrombus especially the LV thrombus Korean J Radiol 15(6), Nov/Dec 2014 kjronline.org using LGE imaging with varying degrees of inversion time is better than that of conventional echocardiography or contrast echocardiography [bib_ref] LV thrombus detection by routine echocardiography: insights into performance characteristics using delayed..., Weinsaft [/bib_ref] [bib_ref] Visualization of ventricular thrombi with contrast-enhanced magnetic resonance imaging in patients with..., Mollet [/bib_ref] [bib_ref] The usefulness of delayed contrast-enhanced cardiovascular magnetic resonance imaging in differentiating cardiac..., Hong [/bib_ref]. The intramural type of LV thrombus is especially best detected by contrast CMR [bib_ref] Contrast-enhanced anatomic imaging as compared to contrast-enhanced tissue characterization for detection of..., Weinsaft [/bib_ref]. Regarding intracardiac tumors, the most important information provided by CMR is extent of tumor and its relationship with adjacent structures. Although malignant tumors are rare, tissue characterization of a tumor would reveal the nature of the tumor. Myxoma is the most common intracardiac tumor and CMR findings of cardiac myxoma show increased signal intensity in T2-weighted images but the signal composition is usually heterogeneous. The differential diagnosis of a high signal intensity lesion on T1-weighted images includes lipoma, tumor with recent hemorrhage, and melanoma (due to the effects of melanin). For the accurate differentiation in this situation, fat saturation technique provides additional information. A lesion with low signal intensity on T1-weighted images may represent a cyst, a signal void in a vascular malformation, a calcified lesion or the presence of air. As water content typically shows high signal intensity on T2-weighted images, intracardiac or pericardial cyst provides high signal intensity. In addition, myxoma, lipoma or metastatic tumor can also be shown to have high signal intensity on T2weighted images. So, for further differentiation, perfusion imaging, early and late gadolinium enhancement imagings are usually needed. In the early phase, after injection at 1-2 minutes, necrotic areas in malignant tumors show up as dark areas surrounded by enhancement elsewhere. In the later phase, malignant tumors typically show contrast enhancement indicating tissue vascularity. Such enhancement pattern is usually absent in cystic lesions and most benign tumors except for myxomas [bib_ref] Clinical indications for cardiovascular magnetic resonance (CMR): Consensus Panel report, Pennell [/bib_ref]. For the differentiation from myxoma, its location and presence of stalk would provide important information. Adjacent tissue infiltration is best estimated by CMR using first pass perfusion imaging and the LGE technique [bib_ref] MR imaging of cardiac tumors and masses: a review of methods and..., Motwani [/bib_ref] [bib_ref] Cardiovascular magnetic resonance of primary tumors of the heart: a review, Fieno [/bib_ref] [bib_ref] Comparison of echo and MRI in the imaging evaluation of intracardiac masses, Gulati [/bib_ref].
Evaluation of cardiac mass (suspected tumor or thrombus)/use of contrast for perfusion and enhancement (Level of evidence: A, Appropriateness criteria: A)

## Clinical scenario 16: evaluation of pericardium
Cardiac magnetic resonance can provide information about the accurate amount of pericardial effusion and pericardial thickness [bib_ref] Assessment of ventricular coupling with realtime cine MRI and its value to..., Francone [/bib_ref] [bib_ref] Noninvasive imaging techniques of constrictive pericarditis, Mastouri [/bib_ref]. Using LGE with fat saturation techniques, the degree of pericardial inflammation can be assumed in patients with constrictive pericarditis. Therefore it can predict the effectiveness of intensive anti-inflammatory medications before a pericardiectomy [bib_ref] Pericardial delayed hyperenhancement with CMR imaging in patients with constrictive pericarditis undergoing..., Zurick [/bib_ref]. Pericardial tumors are also detected and their tissue characterization is also possible with good reliability. The absence of the pericardium can be suspected by a leftward shift of the long axis LV. Any protrusion of any portion of the heart can suggest pericardial absence.
Evaluation of pericardium (pericardial mass, constrictive pericarditis) (Level of evidence: B, Appropriateness criteria: A)

## Clinical scenario 17: evaluation for aortic dissection
MR angiography has been accepted as a good modality for detecting a dissection flap and entry tear site. Transesophageal echocardiography or CT scans are widely used modalities. However the aortic arch is a weak point with transesophageal echocardiography and CT scans need iodine contrast agents and radiation. A previous study shows that cardiac CT or CMR have advantages over transthoracic echocardiography. In a meta-analysis of 1139 patients, the pooled sensitivity (98-100%) and specificity were comparable between these imaging techniques. The pooled positive likelihood ratio appeared to be higher for CMR (positive likelihood ratio, 25.3; 95% CI [11.1-57.1]) than for transesophageal echocardiography (14.1; 6.0-33.2) or helical CT (13.9; 4.2-46.0) [bib_ref] Diagnostic accuracy of transesophageal echocardiography, helical computed tomography, and magnetic resonance imaging..., Shiga [/bib_ref].
Evaluation for aortic dissection (Level of evidence: A, Appropriateness criteria: A)

## Clinical scenario 18: evaluation of pulmonary veins prior to radiofrequency ablation for atrial fibrillation/ left atrial and pulmonary venous anatomy including dimensions of veins for mapping purposes
An accurate anatomic view of the left atrium and pulmonary veins is essential before radiofrequency ablation of pulmonary veins in patients with atrial fibrillation. Currently cardiac CT provides excellent images to guide catheter-based pulmonic vein isolation, and CMR can also provide excellent imaging views about anatomical variants of the pulmonic vein [bib_ref] Direct comparison of computed tomography and magnetic resonance imaging for characterization of..., Lacomis [/bib_ref] [bib_ref] Pulmonary vein anatomy in patients undergoing catheter ablation of atrial fibrillation: lessons..., Kato [/bib_ref] [bib_ref] Three-dimensional anatomy of the left atrium by magnetic resonance angiography: implications for..., Mansour [/bib_ref]. Some studies have reported Korean J Radiol 15(6), Nov/Dec 2014 kjronline.org that diverse variations of the pulmonic vein exist and these have been well correlated with cardiac CT and CMR [bib_ref] Direct comparison of computed tomography and magnetic resonance imaging for characterization of..., Lacomis [/bib_ref].
Evaluation of pulmonary veins prior to radiofrequency ablation for atrial fibrillation/left atrial and pulmonary venous anatomy including dimensions of veins for mapping purposes (Level of evidence: B, Appropriateness criteria: A)

## Clinical scenario 19: anatomic assessment before percutaneous device closure of asd or vsd/anatomic assessment before percutaneous aortic valve replacement
The accurate measurement of ASD shape and size is essential in the selection of an appropriate device. Accurate classification of the ASD type, non-invasive measurement of Qp/Qs (pulmonary flow/systemic flow ratio), and detection of concomitant congenital anomaly are extremely important and can be reliably done by CMR. Several studies have shown that CMR based ASD correlated well to transesophageal echocardiography based on defects size. En face CMR with an optimized imaging plane can determine ASD flow, size, and morphology [bib_ref] Cardiac magnetic resonance imaging of atrial septal defect for transcatheter closure, Durongpisitkul [/bib_ref] [bib_ref] Atrial septal defects type II: noninvasive evaluation of patients before implantation of..., Weber [/bib_ref]. reported that CMR provided information incremental to comprehensive standard evaluation that altered clinical management in 20% of patients. Recently, the catheterbased percutaneous aortic valve replacement has been introduced and the number of this procedure being performed has increased markedly. While transesophageal echocardiography and cardiac CT are known to provide excellent anatomical and functional images of the left ventricular outflow tract, the relationship to the coronary ostium, and the severity of calcification, CMR has been reported to provide good information albeit with a tendency to have larger values than transthoracic echocardiography for all measurements [bib_ref] Cardiovascular magnetic resonance for the assessment of patients undergoing transcatheter aortic valve..., Manna [/bib_ref].
Anatomic assessment before percutaneous device closure of ASD or VSD/anatomic assessment before percutaneous aortic valve replacement (Level of evidence: B, Appropriateness criteria: A) 
[table] Table 1: Definition of Levels of Evidence [/table]