Xenobiotic responsive element gene transcriptions
The classical recognition motif of the AhR/ARNT complex, referred to as either the AhR-, dioxin- or xenobiotic- responsive element (AHRE, DRE or XRE), contains the core sequence 5'-GCGTG-3' within the consensus sequence 5'-T/GNGCGTGA/CG/CA-3' in the promoter region of AhR responsive genes. The AhR/ARNT heterodimer directly binds the AHRE/DRE/XRE core sequence in an asymmetric manner such that ARNT binds to 5'-GTG-3' and AhR binding 5'-TC/TGC-3'. Recent research suggests that a second type of element termed AHRE-II, CATG(N6)CTG, is capable of indirectly acting with the AhR/ARNT complex.

# Human genes
Gene ID: 196 is AHR aryl hydrocarbon receptor on 7p21.1. "The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes."

# Gene expressions

# Interactions

# Consensus sequences
(G/T)NGCGTG(A/C)(C/G)A is the consensus sequence for AHRE, DRE or XRE.
CATGN6C(A/T)TG is the consensus sequence for AHRE-II.

# Binding site for

# Promoter occurrences

# Hypotheses
- A1BG has no regulatory elements in either promoter.
- A1BG is not transcribed by a regulatory element.
- No regulatory element participates in the transcription of A1BG.

# AHRE-II samplings
Copying a responsive elements consensus sequence CATGN6C(A/T)TG and putting the sequence in "F" finds none between ZNF497 and A1BG or none between ZSCAN22 and A1BG as can be found by the computer programs.
For the Basic programs testing consensus sequence CATGN6C(A/T)TG (starting with SuccessablesAHREII.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:
- negative strand, negative direction, looking for CATGN6C(A/T)TG, 0.
- positive strand, negative direction, looking for CATGN6C(A/T)TG, 1, CATGGTGGCTCATG at 4116.
- positive strand, positive direction, looking for CATGN6C(A/T)TG, 0.
- negative strand, positive direction, looking for CATGN6C(A/T)TG, 0.
- complement, negative strand, negative direction, looking for GTACN6G(A/T)AC, 1, GTACCACCGAGTAC at 4116.
- complement, positive strand, negative direction, looking for GTACN6G(A/T)AC, 0.
- complement, positive strand, positive direction, looking for GTACN6G(A/T)AC, 0.
- complement, negative strand, positive direction, looking for GTACN6G(A/T)AC, 0.
- inverse complement, negative strand, negative direction, looking for CA(A/T)GN6CATG, 0.
- inverse complement, positive strand, negative direction, looking for CA(A/T)GN6CATG, 1, CATGGTGGCTCATG at 4116.
- inverse complement, positive strand, positive direction, looking for CA(A/T)GN6CATG, 0.
- inverse complement, negative strand, positive direction, looking for CA(A/T)GN6CATG, 0.
- inverse negative strand, negative direction, looking for GT(A/T)CN6GTAC, 1, GTACCACCGAGTAC at 4116.
- inverse positive strand, negative direction, looking for GT(A/T)CN6GTAC, 0.
- inverse positive strand, positive direction, looking for GT(A/T)CN6GTAC, 0.
- inverse negative strand, positive direction, looking for GT(A/T)CN6GTAC, 0.

## AHREII UTRs
Positive strand, negative direction: CATGGTGGCTCATG at 4116.

# AHRE-II random dataset samplings
- AHRE-IIr0: 0.
- AHRE-IIr1: 0.
- AHRE-IIr2: 0.
- AHRE-IIr3: 0.
- AHRE-IIr4: 0.
- AHRE-IIr5: 0.
- AHRE-IIr6: 0.
- AHRE-IIr7: 0.
- AHRE-IIr8: 0.
- AHRE-IIr9: 0.
- AHRE-IIr0ci: 0.
- AHRE-IIr1ci: 0.
- AHRE-IIr2ci: 0.
- AHRE-IIr3ci: 0.
- AHRE-IIr4ci: 0.
- AHRE-IIr5ci: 0.
- AHRE-IIr6ci: 0.
- AHRE-IIr7ci: 0.
- AHRE-IIr8ci: 0.
- AHRE-IIr9ci: 0.

# AHRE-II analysis and results
CATGN6C(A/T)TG is the consensus sequence for AHRE-II.
Comparison:
Between ZSCAN22 and A1BG (negative direction) on the positive strand is the consensus sequence CATGGTGGCTCATG at 4116. For four strands (2) and directions (2) there is only only occurrence for 0.25. Using twenty random datasets (ten for the direct and ten for the complement inverse), no consensus sequence for AHRE-II was found for an occurrence of 0.0. This suggests that the one occurrence is not random but likely active or activable.
The occurrences of real AHRE-II is greater than the randoms. This suggests that the real AHRE-II is likely active or activable.

# Acknowledgements
The content on this page was first contributed by: Henry A. Hoff.