Co-amoxiclav drug interactions

## Probenecid
Probenecid decreases the renal tubular secretion of
amoxicillin. Concurrent use with Co-amoxiclav may result in increased and
prolonged blood levels of amoxicillin. Coadministration of probenecid
cannot be recommended.

## Allopurinol and Ampicillin
The concurrent administration of allopurinol and ampicillin increases substantially
the incidence of rashes in patients receiving both drugs as compared
to patients receiving ampicillin alone. It is not known whether this
potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia
present in these patients. There are no data with Co-amoxiclav and allopurinol
administered concurrently.

## Broad-Spectrum Antibiotics
In common with other broad-spectrum antibiotics, Co-amoxiclav may
reduce the efficacy of oral contraceptives.

# Complete List of Drug Interactions
Augmentin is a multi-ingredient drug consisting of:
- amoxicillin
- clavulanic acid
Interactions with each of its ingredients have been shown below:

# Amoxicillin Drug Interactions
Amoxicillin is known to interact with the following drugs:

## Major Interactions
- Folex PFS
- methotrexate
- Methotrexate Sodium Preservative Free
- Rheumatrex Dose Pack
- Trexall

## Moderate Interactions
- Adoxa
- Adoxa CK
- Adoxa TT
- Ala-Tet
- Alodox
- Amersham Indium (111In) Oxine
- anisindione
- ARI Sodium Iodide (I123) 1-12 MBq
- ARI Sodium Iodide (I123) 100-750 MBq
- balsalazide
- Benefiber (guar gum formulation)
- Benefiber Orange Creme
- Benefiber Orange Creme Sugar Free
- Benefiber Plus Calcium
- Benefiber Plus Calcium Sugar Free
- Brodspec
- CellCept
- Chloracol
- chloramphenicol
- Chloromycetin
- Chloromycetin Sodium Succinate
- Colazal
- Coumadin
- Declomycin
- demeclocycline
- dicumarol
- Doryx
- Doxy Lemmon
- Doxy-Caps
- Doxy-D
- doxycycline
- doxycycline hyclate
- doxycycline monohydrate
- Dynacin
- Emtet-500
- Estinyl
- ethinyl estradiol
- guar gum
- indium oxyquinoline In-111
- Iodotope
- Jantoven
- mestranol
- Minocin
- Minocin PAC
- minocycline
- minocycline extended release
- Miradon
- Monodox
- mycophenolate mofetil
- mycophenolic acid
- Myfortic
- Myrac
- Oracea
- Oraxyl
- oxytetracycline
- Panmycin
- Periostat
- Resource Benefiber
- Robitet 500
- sodium iodide I-123
- sodium iodide-I-131
- Solodyn
- Sumycin
- Terramycin
- Tetracap
- Tetracon
- tetracycline
- typhoid vaccine live
- Vectrin
- Vibra-Tabs
- Vibramycin
- Vibramycin Calcium
- Vibramycin Hyclate
- Vibramycin Monohydrate
- Vivotif Berna
- warfarin

## Minor Interactions
- allopurinol
- Aloprim
- amiloride
- azithromycin
- Azithromycin 3 Day Dose Pack
- Azithromycin 5 Day Dose Pack
- azithromycin extended release
- Benemid
- Biaxin
- Biaxin XL
- Biaxin XL-Pak
- clarithromycin
- clarithromycin extended release
- dirithromycin
- Dynabac
- Dynabac D5-Pak
- E-Mycin
- E.E.S. Granules
- E.E.S.-200
- E.E.S.-400
- E.E.S.-400 Filmtab
- Ery-Tab
- Eryc
- EryPed
- EryPed 200
- EryPed 400
- Erythrocin Lactobionate
- Erythrocin Stearate Filmtab
- Erythrocot
- erythromycin
- erythromycin base
- erythromycin estolate
- erythromycin ethylsuccinate
- erythromycin lactobionate
- erythromycin stearate
- Ilosone
- Ilotycin Gluceptate
- Lopurin
- Midamor
- MY-E
- PCE Dispertab
- probenecid
- Robimycin
- Tao
- troleandomycin
- Z-Pak
- Zithromax
- Zithromax IV
- Zithromax TRI-PAK
- Zithromax Z-Pak
- Zmax
- Zyloprim

# Clavulanic Acid (Clavulanate) Drug Interactions

## Moderate Interactions
- Arava
- Avonex
- Avonex Prefilled Syringe
- balsalazide
- Betaseron
- clofarabine
- Clolar
- Colazal
- echinacea
- Folex PFS
- interferon beta-1a
- interferon beta-1b
- leflunomide
- methotrexate
- Methotrexate Sodium Preservative Free
- naltrexone
- Rebif
- ReVia
- Rheumatrex Dose Pack
- thioguanine
- Trexall
- Vivitrol
Adapted from the FDA Package Insert.