Persius/hicric huggingface dataset:
Summary of key recommendations

# 2013 Summary of Key Recommendations for the Treatment of Blood Cholesterol to Reduce ASCVD Risk in Adults

## A. Heart-healthy lifestyle habits should be encouraged for all individuals

## B. The appropriate intensity of statin therapy should be initiated or continued

## C. Regularly monitor adherence to lifestyle and drug therapy with lipid and safety assessments

## D. In individuals intolerant of the recommended intensity of statin therapy, use the maximally tolerated intensity of statin
*Clinical ASCVD includes acute coronary syndromes, history of MI, stable or unstable angina, coronary or other arterial revascularization, stroke, TIA, or peripheral arterial disease presumed to be of atherosclerotic origin.Estimated 10-year or hard ASCVD risk includes first occurrence of nonfatal MI, CHD death, and nonfatal and fatal stroke as used by the Risk Assessment Work Group in developing the Pooled Cohort Equations.These factors may include primary LDL-C !160 mg/dL or other evidence of genetic hyperlipidemias; family history of premature ASCVD with onset <55 years of age in a first-degree male relative or <65 years of age in a first-degree female relative; hs-CRP 2 mg/L; CAC score 300 Agatston units or 75th percentile for age, sex, and ethnicity (for additional information, see / CACReference.aspx); ABI <0.9; or lifetime risk of ASCVD. Additional factors that might aid in individual risk assessment could be identified in the future.High-risk individuals include those with clinical ASCVD, an untreated LDL-C !190 mg/dL suggesting genetic hypercholesterolemia, or individuals with diabetes 40 to 75 years of age and LDL-C 70 to 189 mg/dL.
Syndrome of subjective doubles

# Overview
The syndrome of subjective doubles is a rare delusional misidentification syndrome in which a person suffers from the delusion that he or she has a double or doppelganger with the same appearance, but usually with different character traits and leading a life of its own. Sometimes the patient has the idea that there is more than one double. The syndrome is usually the result of a neurological disorder, mental disorder or some form of brain damage, particularly to the right cerebral hemisphere.
Sometimes the delusion takes the form of a conviction that whole or part of the patient's personality has been transferred into another person. In this case depersonalization may be a symptom. One example from medical literature is of a man who became depersonalized after an operation and was convinced his brain had been placed into someone else's head. He later claimed he recognized this person.
The syndrome is sometimes comorbid with Capgras delusion, leading to it to be named "subjective Capgras syndrome" in some instances.
Thyroid transcription factor-1
Thyroid transcription factor-1 (TTF-1) is a protein that regulates transcription of genes specific for the thyroid, lung, and diencephalon.  It is also known as thyroid specific enhancer binding protein.  It is used in anatomic pathology as a marker to determine if a tumor arises from the lung or thyroid.
TTF-1 positive cells are found in type II pneumocytes and Clara cells in the lung.  In the thyroid, follicular and parafollicular cells are positive.
For lung cancers, adenocarcinomas are usually positive, while squamous cell carcinomas and large cell carcinomas are rarely positive. Small cell carcinomas (of any primary site) are usually positive.
Telavancin labels and packages

# Labels And Packages

## PACKAGE LABEL  PRINCIPAL DISPLAY PANEL  250 MG/VIAL LABEL
NDC 0469-3525-30
1 Vial
VibativTM
(telavancin hydrochloride)
Equivalent to 250 mg telavancin
Rx only
Astellas

## PACKAGE LABEL  PRINCIPAL DISPLAY PANEL  250 MG/VIAL CARTON
NDC 0469-3525-30
1 Carton containing 1 Vial of 250 mg
VibativTM
(telavancin hydrochloride)
Equivalent to 250 mg telavancin per vial
Rx only
Astellas

## PACKAGE LABEL  PRINCIPAL DISPLAY PANEL  750 MG/VIAL LABEL
NDC 0469-3575-50
1 Vial
VibativTM
(telavancin hydrochloride)
Equivalent to 750 mg telavancin
Rx only
Astellas

## PACKAGE LABEL  PRINCIPAL DISPLAY PANEL  750 MG/VIAL CARTON
NDC 0469-3575-50
1 Carton containing 1 Vial of 750 mg
VibativTM
(telavancin hydrochloride)
Equivalent to 750 mg telavancin per vial
Rx only
Astellas
Telithromycin clinical studies

# Clinical Studies

## Community-acquired pneumonia (CAP)
KETEK was studied in four randomized, double-blind, controlled studies and four open-label studies for the treatment of community-acquired pneumonia. Patients with mild to moderate CAP who were considered appropriate for oral outpatient treatment were enrolled in these trials.  Patients with severe pneumonia were excluded based on any one of the following: ICU admission, need for parenteral antibiotics, respiratory rate > 30/minute, hypotension, altered mental status, < 90% oxygen saturation by pulse oximetry, or white blood cell count < 4000/mm3. Total number of clinically evaluable patients in the telithromycin group included 2016 patients.
Clinical cure rates by pathogen from the four CAP controlled clinical trials in microbiologically evaluable patients given KETEK for 710 days or a comparator are displayed in Table 7.
Clinical cure rates for patients with CAP due to Streptococcus pneumoniae were determined from patients in controlled and uncontrolled trials.  Of 333 evaluable patients with CAP due to Streptococcus pneumoniae, 312 (93.7%) achieved clinical success.  Only patients considered appropriate for oral outpatient therapy were included in these trials.  More severely ill patients were not enrolled.  Blood cultures were obtained in all patients participating in the clinical trials of mild to moderate community-acquired pneumonia. In a limited number of outpatients with incidental pneumococcal bacteremia treated with KETEK, a clinical cure rate of 88% (67/76) has been observed. KETEK is not indicated for the treatment of severe community-acquired pneumonia or suspected pneumococcal bacteremia.
Clinical cure rates for patients with CAP due to multi-drug resistant Streptococcus pneumoniae (MDRSP*) were determined from patients in controlled and uncontrolled trials. Of 36 evaluable patients with CAP due to MDRSP, 33 (91.7%) achieved clinical success.
- MDRSP: Multi-drug resistant Streptococcus pneumoniae includes isolates known as PRSP (penicillin-resistant Streptococcus pneumoniae), and are isolates resistant to two or more of the following antibiotics: penicillin, 2nd generation cephalosporins, e.g., cefuroxime, macrolides, tetracyclines and trimethoprim/sulfamethoxazole.

## Visual Adverse Events
Table 9 provides the incidence of all treatment-emergent visual adverse events in controlled Phase III studies by age and gender. The group with the highest incidence was females under the age of 40, while males over the age of 40 had rates of visual adverse events similar to comparator-treated patients.
The heart in oncologic disease

# Imaging

## CT
Labeled images below are courtesy of RadsWiki and copylefted.
- Atrial Myxoma
- Atrial Myxoma
- Atrial Myxoma
- Atrial Myxoma
- Cardiac Rhabdomyosarcoma
- Cardiac Rhabdomyosarcoma
- Cardiac Rhabdomyosarcoma
- Cardiac Rhabdomyosarcoma

## Pathological Findings
Image shown below is courtesy of Professor Peter Anderson DVM PhD and published with permission.  PEIR, University of Alabama at Birmingham, Department of Pathology
- HEART: Metastatic Tumor: Gross very unusual large metastatic carcinoid in right atrium
- Cardiac Myxoma A gelatinous tumor is attached by a narrow pedicle to the atrial septum. The myxoma has an irregular surface and nearly fills the left atrium.
- Cardiac Myxoma There was a calcified right atrial mass on the X ray of a 47-year-old man. Resection demonstrated a smooth-surfaced tumor. The gritty material seen microscopically on cut section was calcified and ossified myxoma.
- Cardiac Fibroma Cut surface of the tumor shown in figure 6-2. The left ventricular (LV) cavity is present behind the mass. The patient was a 4-month-old child who died suddenly without a previous medical history.
- This tumor was resected from the right atrium of a 1-year-old boy with pericardial effusions. Note areas of hemorrhage and dilated vessels. The patient was well 49 months postoperatively.
- Papillary fibroelastomas are often on the arterial surface and may project into the coronary ostium, causing ostial occlusion. This tumor is in the noncoronary sinus.

# The Heart in Central and Peripheral Nervous System Cancers

# The Heart in Leukemias

# The Heart in Multiple Myeloma

# The Heart in Urinary System Tumors

# The Heart in Lung Cancers

# The Heart in Thyroid and Parathyroid Cancers

# The Heart in Osteosarcomas

# The Heart in Breast Cancer

# The Heart in Gastrointestinal, Hepatobilier & Pancreatic Tumors

# The Heart in Skin Cancers

# The Heart in Gynecologic Tumors

# The Heart in Peritoneal and Mesothelial Tumors

# The Heart in Head and Neck Tumors

# The Heart in Lymphomas

# The Heart in Tumors that Originated from Vascular Structure

# The Heart in Primary Myocardial Tumors
Thymosin beta-4, Y-chromosomal
Thymosin beta-4, Y-chromosomal is a protein that in humans is encoded by the TMSB4Y gene.
The protein consists (in humans) of 44 amino acids (msdkpgmaei ekfdksklkk tetqeknpls sketieqerq ages) MolWt 4881.

# Function
This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X (thymosin beta-4) escapes X inactivation and encodes an actin sequestering protein.
Topiramate labels and packages
For patient information about topiramate, click here.

# Labels and Packages
PACKAGE LABEL-PRINCIPAL DISPLAY PANEL - 25 mg (60 Tablet Bottle)
NDC 65862-171-60
Topiramate Tablets USP
25 mg
PHARMACIST: PLEASE DISPENSE WITH
MEDICATION GUIDE PROVIDED SEPARATELY
Rx only           60 Tablets
AUROBINDO
PACKAGE LABEL-PRINCIPAL DISPLAY PANEL - 50 mg (60 Tablet Bottle)
NDC 65862-172-60
Topiramate Tablets USP
50 mg
PHARMACIST: PLEASE DISPENSE WITH
MEDICATION GUIDE PROVIDED SEPARATELY
Rx only           60 Tablets
AUROBINDO
PACKAGE LABEL-PRINCIPAL DISPLAY PANEL - 100 mg (60 Tablet Bottle)
NDC 65862-173-60
Topiramate Tablets USP
100 mg
PHARMACIST: PLEASE DISPENSE WITH
MEDICATION GUIDE PROVIDED SEPARATELY
Rx only           60 Tablets
AUROBINDO
PACKAGE LABEL-PRINCIPAL DISPLAY PANEL - 200 mg (60 Tablet Bottle)
NDC 65862-174-60
Topiramate Tablets USP
200 mg
PHARMACIST: PLEASE DISPENSE WITH
MEDICATION GUIDE PROVIDED SEPARATELY
Rx only           60 Tablets
AUROBINDO
Adapted from the FDA Package Insert.
Tricho-hepato-enteric syndrome

# Overview
It is a rare genetic disorder presenting in children less than 1 year of age.

# Pathophysiology
- It is a genetic disorder with an autosomal recessive inheritance pattern.
- Mutations in TTC37 which encodes the putative protein Thespin, have recently been associated with Tricho-Hepato-Enteric syndrome. 

# Natural History, Complications and Prognosis
- Prognosis is poor.
- Many patients die before the age of 5  due to infections or cirrhosis.

# Diagnosis

## Symptoms
- Failure to thrive
- Intractable diarrhea
- Intrauterine growth retardation
- Hair  abnormalities - prominent forehead and cheeks, a broad nasal root and widely spaces eyes (hypertelorism)
- Facial abnormalities - their hairs are woolly, easily removed and poorly pigmented

## Physical Examination
- Signs of liver failure

## Laboratory Tests

### Biopsy
- Small bowel - villous atrophy with low or no mononuclear cell infiltration of the lamina propria
- Microscopic analysis of the hair -  twisted hairs of unequal size and different shapes

## Other Diagnostic studies
- Scanning electron microscopy of hair -  hair budding
- Biochemical analysis of hair reveal -  sulfur-deficient brittle hair
- Abnormal antibody generation - T cell dysfuntion

# Treatment
- No specific treatment
- Total parenteral nutrition may reduce symptoms of diarrhea
- Avoiding further damage to the liver
Trimethoprim adverse reactions

# Adverse Reactions
To report SUSPECTED ADVERSE REACTIONS, contact FSC Laboratories, Inc. at 1-866-764-7822, or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Adverse Events Reported During Pediatric Clinical Trials With PRIMSOL
The following table lists those drug-related adverse events reported most frequently during the clinical trials in pediatric patients aged 6 months to 12 years. Most of these events were determined to be mild. The incidence of drug-related adverse events was significantly lower for PRIMSOL, which was most apparent for those events related to skin/appendages as a body system.
Adverse Reactions Reported For Trimethoprim
In addition to the adverse events listed above which have been observed in pediatric patients receiving PRIMSOL, the following adverse reactions and altered laboratory tests have been previously reported for trimethoprim and therefore, may occur with PRIMSOL therapy:
Dermatologic reactions: pruritus and exfoliative dermatitis. At the recommended adult dosage regimens of 100 mg b.i.d., or 200 mg q.d., each for 10 days, the incidence of rash is 2.9% to 6.7%. In clinical studies which employed high doses of trimethoprim in adults, an elevated incidence of rash was noted. These rashes were maculopapular, morbilliform, pruritic and generally mild to moderate, appearing 7 to 14 days after the initiation of therapy.
Gastrointestinal reactions: Epigastric distress,nausea, and glossitis.
Hematologic reactions: Thrombocytopenia, leukopenia, neutropenia, megaloblastic anemia and methemoglobinemia.
Metabolic reactions: Hyperkalemia, hyponatremia.
Miscellaneous reactions: Fever, elevation of serum transaminase and bilirubin, and increases in BUN and serum creatinine levels.
Tundra Symbiotic Relationships

# Tundra Symbiotic Relationships

# Tundra Symbiotic Relationships
Biomes of the World - tundra. Some have lifelong relationships with other organisms, called symbiotic There are three different types of symbiotic relationships: mutualism,. Arbuscular Mycorrhizal Symbiosis (Live Imaging) .
Forest, grassland, freshwater, marine, and tundra biomes.

### Tundra Symbiotic Relationships
- Tundra and taiga biomes in alaska plants in taiga fungi in the Tundra Energy Pyramid Symbiotic Relationships for Arctic Fox Polar Bears Abiotic Factors.
Lesson, how to disappear in a relationship, commensalism relationship in tundra symbiotic relationships in grassland.
Tundra ? temperate forest ? taiga ? desert ? tropical that grow on the roots of mazda t3500 3 ton truck are representative of chat voice egypte type of symbiotic relationship.
- Lesson, how to disappear in a relationship, commensalism relationship in tundra symbiotic relationships in grassland.
Tundra ? temperate forest ? taiga ? desert ? tropical that grow on the roots of mazda t3500 3 ton truck are representative of chat voice egypte type of symbiotic relationship.
- Tundra ? temperate forest ? taiga ? desert ? tropical that grow on the roots of mazda t3500 3 ton truck are representative of chat voice egypte type of symbiotic relationship.
406-861-7870. Click above image to view more pics of the Toyota Tundra Diesel Dually With a strong OEM presence at SEMA, automakers are forced to bring The Badass to the masses. Homework Help - Symbiotic Relationships ? Statistics Children In Single Parent Homes Help - Tundra Biomes & Ecosystems. What is the average annual precipitation in the tundra? a) 5-15 cm. 
7) Tundra Obj: 9.7 The student will describe symbiotic relationships among populations. Examples of Biomes are tundra, temperate grassland, desert and tropical rainforest.
- All terrestrial habitats, including arable land, deserts, grasslands, tropical forests, and tundras.
- Symbiotic relationships are when one organism helps another organism.
- One example of a symbiotic relationship is when entry level web designer jobs bark beetle eats the bark of Mla In Text Citation For Websites oak tree. Amytsang: Parasitism doorman job nyc entry level job titles form of symbiotic relationship in which one organism benefits at the expense of an organism of a different species. Symbiosis - parasites, mutualism, commensalism, symbiotic relationship.
- Describes the northern biotic area that is dominated by tundra it trust relationship domain controller damage) the host; parasitic - adj.; parasitism - n. Quotes on sibling relationships.
Wikipedia
U.S. Naval Hospital, Subic Bay
U.S. Naval Hospital, Subic Bay (also the Navy Regional Medical Center) was the main medical facility of the U.S. Naval Forces, Philippines.  In 1992, after the Philippine government decided not to renew that agreement with the U.S. for bases, the Subic Bay Naval Base (along with Clark Air Force Base) were abandoned by the U.S.

# History
U.S. Naval Hospital at Subic Bay was opened on 13 July 1956 as U.S. Naval Station Hospital, Subic Bay.  In January 1973, the hospital expanded its command scope, adding the dispensaries at Naval Station Subic Bay, Naval Air Station Cubi Point, Naval Communication Transmitting Facility, Capas in Tarlac, and the Joint Military Group Manila.  On 7 March 1977, the Hospital was designated as a Regional Medical Center.  On 1 August 1983, the Naval Medical Command, Pacifc Region, Hawaii became the Subic Bay U.S. Naval Hospital's parent command.  In 1989, the U.S. Navy Medical command was reorganized and the hospital began to report directly to the Commander, U.S. Naval Forces, Philippines.
The hospital had 90 beds, with the ability to expand to 141 beds.
Valvular heart disease surgery

# Overview
The following section discusses the recommendations for patients with valvular heart disease undergoing surgery and other procedures. For more information about the specific surgical intervention for each valvular pathology, refer to to any of the following:
- Aortic stenosis
- Aortic regurgitation
- Pulmonary stenosis
- Pulmonary regurgitation
- Mitral stenosis
- Mitral regurgitation
- Tricuspid stenosis
- Tricuspid regurgitation

# 2014 AHA/ACC Guideline for The Management of Patients with Valvular Heart Disease

## Surgical Considerations: Recommendations

### Evaluation of Coronary Anatomy

### Concomitant Procedures
Intervention for CAD
Intervention for AF

## Noncardiac Surgery in Patients With VHD: Recommendations

# 2008 and Incorporated 2006 ACC/AHA Guidelines for the Management of Patients with Valvular Heart Disease (DO NOT EDIT) 

## Diagnosis of Coronary Artery Disease before the Surgery (DO NOT EDIT) 

# Sources
- 2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease
Vancomycin labels and packages
Baxter Healthcare Corporation
Deerfield, IL 60015 USA
Printed in USA
Baxter and Galaxy are registered trademarks of Baxter International Inc.
Revised, October 2011
PACKAGE LABEL - PRINCIPAL DISPLAY PANEL
Baxter
Vancomycin
Injection, USP
750 mg
GALAXY
Single-Dose
Container
150 mL
Iso-osmotic
NDC 0338-3580-48
Code 2G3580
Sterile Nonpyrogenic
Each 100 mL contains: Vancomycin Hydrochloride, USP
equivalent to 500 mg vancomycin with approx. 5 g Dextrose
Hydrous, USP. pH may have been adjusted with hydrochloric acid
and/or sodium hydroxide. pH range 3.0 to 5.0.
Dosage: Intravenously as directed by a physician. See package
insert.
Cautions: Do not add supplementary medication. Must not be
used in series connections. Check for minute leaks and solution
clarity.
Rx Only
Store at or below -20C (-4F). Thaw at room temperature
(25C/77F) or under refrigeration (5C/41F). DO NOT FORCE 
THAW BY IMMERSION IN WATER BATHS OR BY MICROWAVE 
IRRADIATION. Thawed solution is stable for 30 days under
refrigeration or 72 hours at room temperature. Do not refreeze.
Baxter and GALAXY are trademarks of Baxter International Inc.
Baxter Healthcare Corporation, Deerfield, IL 60015 USA
PL 2040 Plastic
Baxter Logo
Vancomycin Injection, USP
3 - 150 mL Single Dose Containers Iso-osmotic
Store at or below -20C/-4F. Do not refreeze.
750 mg
Baxter Healthcare Corporation
Deerfield, IL 60015 USA
NDC 0338-3580-48
Code 2G3580
- FOR BAR CODE POSITION ONLY
GALAXY Container
Sterile Nonpyrogenic
Each 100 mL contains: Vancomycin Hydrochloride, USP equivalent to 500 mg vancomycin with approx. 5 g Dextrose Hydrous, USP. pH may have been adjusted with hydrochloric acid and/or sodium hydroxide. pH range 3.0 to 5.0
Dosage: Intravenously as directed by a physician. See package insert.
Cautions: DO NOT ADD SUPPLEMENTARY MEDICATION. Must not be used in series connections. Check for minute leaks by squeezing thawed bag firmly. If leaks are found, discard bag as sterility may be impaired. Do not use unless solution is clear. Rx Only.
Thaw at room temperature (25C/77F) or under refrigeration (5C/41F). DO NOT FORCE THAW BY IMMERSION IN WATER BATHS OR BY MICROWAVE IRRADIATION. The thawed solution in GALAXY plastic container (PL 2040) remains chemically stable for 72 hours at room temperature or for 30 days when stored under refrigeration. Do not refreeze.
Handle frozen product containers with care. Product containers may be fragile in the frozen state.
Baxter and Galaxy are registered trademarks of Baxter International Inc.
PL 2040 Plastic
LAB-0494-2.0
January 2013
PRINCIPAL DISPLAY PANEL - 10 g Bottle Carton
NDC 0069-2599-99
Rx only
VANCOMYCIN
HYDROCHLORIDE
FOR INJECTION, USP
(Formerly: Sterile Vancomycin
Hydrochloride)
PHARMACY BULK PACKAGE
NOT FOR DIRECT INFUSION
10 grams- per
Pharmacy Bulk Package
Sterile
LYOPHILIZED
For IV Infusion After Dilution
AFTER RECONSTITUTION MUST BE FURTHER
DILUTED. NOT TO BE DISPENSED AS A UNIT.
One Pharmacy Bulk Package bottle
Pfizer Injectables
Hospira, Inc., Lake Forest, IL 60045 USA
RL-3426
RL-3423
RL-3427
Vascular access steal syndrome
Synonyms and keywords: Steal syndrome

# Overview
In nephrology, vascular access steal syndrome, also known less precisely as steal syndrome, refers to vascular insufficiency resulting from a poorly constructed arteriovenous fistula (Cimino fistula, or synthetic vascular graft-AV fistula).

# History and Symptoms
- Pain distal to the fistula.

# Physical Examination
- Pallor
- Diminished pulses (distal to the fistula)
- Necrosis
- Decreased wrist-brachial index (ratio of blood pressure measured in the wrist and the blood pressure measured in the upper arm)

# Diagnosis
- Arteriography

# Treatment
- Access ligation/vein banding (banding of the fistula or a vessel distal to the fistula to restrict flow through the fistula)