Nonsuicidal self-injury
Synonyms and keywords: Self-harm (SH), Self-inflicted violence (SIV), self-injury (SI), Non suicidal self injury (NSSI) or self-injurious behavior (SIB),

# Overview
Non-suicidal Self Injury means the intentional or conscious effort by someone to destruct his or her own body tissues with out having any intent for suicidality. The most common examples associated with NSSI includes cutting, scratching, burning, banging, self hitting. Mostly the people who self injure themselves are having the history of using two or more methods out of what described before. Because NSSI is frequently connected with emotional and psychiatric discomfort, as well as an increased risk of suicide, correct establishment of conceptual and clinical models of this behavior are critical.
The Non suicidal Self Injury is most commonly seen in young adults and adolescents age groups of around 13-14 years with a lifetime rates of 15-20%. But when the stats studied adult population the rate is 6%. Psychiatric groups, particularly those who report features linked with emotional distress, such as negative emotionality, depression, anxiety, and emotion dysregulation, have the highest incidence of NSSI in both adolescents and adult age group. In addition People who are prone to self-directed negative emotions and self-criticism are more likely to develop NSSI. Although it is typical for people to believe that NSSI is more common in women, general population surveys show that men and women have similar rates. However the sex difference makes the contribution when its comes to the point of methods used for NSSI. The women's are more found to be using cutting whereas the men's more often use the method of hitting and burning.

# Historical Perspective
- In early 1844 Bethlem Royal Hospital asylum made clear distinction between "self injury or disposition to suicide"
- In 20th century, Karl Menninger was the first to decribe self harm as a clinical entity.
- In 1871, G. Fielding Blandford, MD, differentiated between, "will harm or mutilate portion of their bodies" and those who "attempt in every manner to put an end to themselves". He defined self mutilations as nail biting, face or hand picking, and hair plucking are common in nervous people.
- In 1896, George Gould and Walter Pyle, divided self mutilation cases into  those committed:
In a period of temporary insanity from melancholia or hallucinations
With suicidal purpose, and
In a religious frenzy or passion.
- In 1883, 1892 James Adam distinguished between self injury with and without psychotic symptoms.
- In 1878, Walter Channing, published a case report of Helen Miller, who was possessed with urges to cut. She resided in an asylum and cut repetitively for 3 years.

# Classification
The Non Suicidal Self Injury also known as Self-harm, Self Injury, Self-inflicted violence, Self Injurious Behavior.  These are the common term used interchangeably by various authors and practioners to name the disease. The behavior entails intentional tissue injury that is usually carried out without a suicidal motive. Cutting the skin with a sharp item, such as a knife or razor blade, is the most prevalent type of self-harm. The word "self-mutilation" is also occasionally used, albeit it has connotations that some people find alarming, inaccurate, or unpleasant.
Soldiers use the term "self-inflicted wounds" to describe non-lethal injuries they cause in order to be released from combat sooner. But this damage is inflicted for a defined secondary aim, which differs from the standard definition of self-harm. We can also say the people who injure their bodies through disordered eating may be included in the definition of self-harm when broader aspect of the disease is considered.
NSSI has been proposed as a disorder in the DSM-5's "Conditions for Further Study" category. It should be noted that this proposed diagnostic criteria for a future diagnosis is not an officially approved diagnosis and should not be utilized in clinical practice; rather, it is intended solely for research purposes. The NSSI is classified as deliberate self-inflicted harm without the intent to commit suicide. The criteria for diagnosing and identifying NSSI includes 5 or more days of self inflicted harm over the duration of one year without having any intention to commit the suicide and along with that the person must have been having a motivation to relief from the negative state or to achieve a positive state.
Self-harm is commonly misunderstood as an attention-seeking behavior; however, this is not always the case. Many self-harmers are self-conscious about their scars and wounds, and they feel bad about their actions, therefore they go to great measures to hide their actions from others. They try to give the alternate reasoning for their scars or try to hide them with clothing. Self-harmers aren't usually trying to take their own lives; instead, it's thought that they're using it as a coping method to ease emotional anguish or discomfort, or as a way to communicate their distress.
Self-harm is dependent on environmental circumstances such as receiving attention or escaping expectations, according to studies of people with developmental disabilities (such as intellectual disability). Some people suffer from dissociation because they want to feel authentic or fit to society's rules.

# Pathophysiology
- Pathophysiology of Non Suicidal Self InjuryEmotional and physical pain activates the same regions of the brain which in some people is the reason for the intolerance of emotional stress. Some of this is attributable to environmental, while others are caused by physiological variations in response. 
- The autonomic nervous system is composed of:
The sympathetic nervous system- controls arousal and physical activation.
The parasympathetic nervous system-controls automatic physical activation.
- The sympathetic nervous system- controls arousal and physical activation.
- The parasympathetic nervous system-controls automatic physical activation.
- Self-injuring adolescents exhibit higher physiological response to stress (e.g., skin conductance) than non self-injuring adolescents. Over time this stress response stays same and sometimes it even increases.
- Self-harmers think that self-injury can lead to relief. For some, relief comes largely from psychological factors, whereas for others, it comes through the release of beta endorphins in the brain. Endorphins are endogenous opioids that are released in reaction to physical damage, functioning as natural analgesics and producing pleasurable sensations, and would also be released in response to self-harm, reducing tension and mental anguish. Self-harm may become psychologically addictive as a coping technique because  it allows the self harmers to deal with extreme anxiety, stress, depression, emotional numbness, and a sense of self-loathing or failure. in the present moment. Its patterns, such as particular time intervals between acts of self-harm, can also result in a behavioural pattern that leads to a desire or urge to act on self-harming ideas.
- Many persons who self-harm claim that it permits them to "get away" or "dissociate," removing their minds from painful sensations. This can be accomplished by convincing the mind that the current suffering is due to the self-harm rather than the difficulties they were dealing with previously: the physical pain serves as a diversion from the initial mental agony.To add to this notion, one can think how important it is to "stop" feeling emotional anguish and mental irritation. "A person may be hypersensitive and overloaded, with a plethora of thoughts whirling about in their heads, and they may get triggered or may decide to stop the overpowering sensations."
- Alternatively, self-harm, on the other hand, might be a way of feeling something, even if it's unpleasant and painful. Anhedonia is a sense of emptiness or numbness experienced by those who self-harm, and physical pain may provide relief from these feelings. "A person might be aloof from oneself, aloof from life, numb and unfeeling."They develop a desire to feel something, and try to create a sesation and "wake up".

# Causes
Self-injury is a complicated condition without any simple explanation. Most people use it as a coping mechanism to deal with the feelings of unreality or numbness, to express distressful emotions, to punish themselves, to stop flashbacks and to relieve tension.
Common causes of Non Suicidal Self Injury
- Psychological factors: Abuse during childhood, troubled relationships with parents or partner, bereavement. Lack of belonging, considering oneself as a burden, feelings of entrapment,defeat, with the onset of pubertal period and sexual activity because of neurodevelopmental vulnerability. Associated with autism spectrum disorders, borderline personality disorder. As an experience of dissociative state and depersonalisation. Unemployment, war and poverty are other contributing factors.
- Mental disorder:The mental illnesses which have an increased associated risk of self-injury are depression, dissociative disorders,  borderline personality disorder, autism spectrum disorders, bipolar disorder, conduct disorders and phobias. OCD, PTSD, Schizophrenia, Substance abuse, poor problem-solving skills and impulsivity, Munchausen syndrome. Eating disorders and anxiety disorders.
- Genetics: The rare genetic condition, LeschNyhan syndrome is characterised by self harm which includes biting and head-banging. Genetics is involved in the development of psychological conditions such as anxiety and depression which may contribute to self-injuring behaviour.
- Drugs and alcohol: Self-harm is linked to chronic substance abuse, dependency, and withdrawal.
- Benzodiazepine dependence as well as benzodiazepine withdrawal.
- Alcohol addiction.
- Cannabis use and intentional self-injury.
- Smoking

# Differentiating Nonsuicidal self-injury from other Diseases

# Epidemiology and Demographics
- The prevalence of NSSI varies between 7.5 and 46.5 percent in teenagers, rising to 38.9 percent among students and 423% among adults. Despite the fact that self-injurious behaviour is a common occurrence, results from different studies differ significantly.
- The beginning of NSSI is most common in early adolescence, between the ages of 12 and 14, however NSSI behavior has also been seen in children under the age of 12.
- Self-cutting is the most prevalent method, followed by burning, head banging, hitting, and sctratching. Most people who engage in NSSI, use a combination of methods to affect their wrists, arms, stomach  and legs.
- The findings of several research studies showed that women exhibited more NSSI behaviors than men.
- Self-cutting is the most prevalent way among women, who are more prone than males to participate in NSSI methods that typically entail blood, whereas burning, hitting and banging are the most common means among men. Among college students, adolescents and adults equal incidence of NSSI has been reported.
- No differences in the race have been seen in the university and adolescent population.
- Multiracial college students have the highest incidence rates in the ethnically varied sample, followed by Caucasian (16.8), and Hispanic (17%). Prevalence rates in Chinese students for NSSI is in the range of 24.9-29.2%. In the Turkish adolescent group it is 21.4%.

# Risk Factors
The common risk factors involved in Non Suicidal Self Injury are as follows:
- Hopelessness
- Prior history of nonsuicidal self-injury
- Cluster B personality disorders: antisocial personality disorders, histrionic, Borderline, narcissistic.
- Psychopathology
Emotional/internalizing problems (eg, depressed affect,negative attributional and style social withdrawal)
Depression
Behavioral/externalizing problems (eg, aggression, substance use and delinquent behaviors)
Disordered eating
- Emotional/internalizing problems (eg, depressed affect,negative attributional and style social withdrawal)
- Depression
- Behavioral/externalizing problems (eg, aggression, substance use and delinquent behaviors)
- Disordered eating
- Distress
- Affect dysregulation
- Sleep problems
- Impulsivity assessed by self-report (rather than laboratory testing)
- Impaired family functioning
- Self-reported likelihood of engaging in future nonsuicidal self-injury
- Prior suicidal thoughts and/or behaviors
- Other negative life events or stressors, including bullying and peer victimization
- History of childhood maltreatment
- Exposure to peers nonsuicidal self-injury
- Parental psychopathology

# Screening
The screening for Non Suicidal Self Injury is done by using the The Functional Assessment of Self-Mutilation (FASM). It gives us an assessment if the person was involved in self harming behaviour in the past one year. The person answers a set of questionnaire in terms of yes,  no,  how many times if its a positive response and if received any treatment.
- Scraped the skin
- Cut or carve on the skin
- "Erased" the  skin
- Gave themselves a tattoo
- Hit oneself on purpose
- Picked at a wound
- Pulled hair out
- Bit themselves (eg, lip or mouth)
- Burned the skin (ie, with a match, cigarette, or other hot object)
- Picked areas of the body to the point of drawing blood
- Inserted objects under the nails or skin

# Diagnosis

## Diagnostic Study of Choice
Most of the people who show self-harming behaviour meet the DSM-5 criteria for Non Suicidal Self Injury.

## History and Symptoms
Eighty percent of self-injury includes stabbing or cutting the skin with a sharp tool, sometimes completely piercing the skin. Self-harm is frequently committed in regions of the body that are readily hidden and undetectable to others. Most often it is a symptom of an underlying disorder and these people look for help to get out of this.
Common signs and symptoms that a person may be engaging in self-harm include the following:
- Self-poisoning,  self-embedding of objects,  hair pulling, burning, alcohol abuse, bruising/hitting one's self,
- Fresh cuts,  bruises, scratches, bite marks or other wounds.
- Knowingly abusing over the counter or prescription drugs,
- Scars, often in patterns
- Excessive rubbing of an area to create a burn
- Self-harm related to anorexia and bulimia.
- Frequent reports of accidental injury
- Keeping sharp objects close by or on hand
- Wearing long sleeves or long pants, even in hot weather
- Statements of helplessness, worthlessness or hopelessness
- Emotional and behavioral instability, unpredictability and impulsivity
- Difficulties in interpersonal relationships

## Physical Examination
During physical examination special attention must be given to orientation and level of consciousness, vital signs and toxidrome manifestations. In addition to this physicians should check for the following: 
- Remote or recent suicide attempts (eg,  bruises from hanging or scars from cutting)
- Sexual or physical abuse (eg, genital trauma or characteristic bruising patterns)
- Substance abuse (eg, perioral blisters or nosebleeds from inhalant use or track marks from intravenous drug use)
- General medical illness (eg, thyroid disease)

## Laboratory Findings
The laboratory evaluation of a suicidal child or adolescent should be tailored to the circumstances of the ideation or attempt, as well as the clinical risk assessment for illicit drug use and complicating medical issues, such as pregnancy and the presence of sexually transmitted diseases.
Screening laboratory tests that are often conducted and typically needed by hospitals before they consider patients for admission are.
- Urine toxicology screen for drugs of abuse, acetaminophen and aspirin
- Serum chemistry panels
- Complete blood count
- Thyroid stimulating hormone
- Urinalysis
- Human chorionic gonadotropin (pregnancy) in girls

## MRI
Resting state fMRI (rsfMRI or R-fMRI) is a method of functional magnetic resonance imaging (fMRI). When fMRI was done on a patient with NSSI, the findings were:
- atypical amygdala-frontal connectivity
- greater amygdala RSFC in dorsal anterior cingulate and supplementary motor area (SMA)
- differential amygdala-occipital connectivity

# Treatment
Short term psychotherapy and pharmacotherapy are effective in decreasing NSSI.
It is important to manage comorbid disorders before giving a trial of medications for self injury. 
Always those interventions are tried first which have greater evidence based effectiveness
- Pharmacotherapy for Nonsuicidal Self-Injury: There are 5 classes of drugs which are effective for NSSI treatment:
SSRIs (for example, fluoxetine)
Atypical antipsychotics
SNRIs (venlafaxine),
Opioids (buprenorphine), and
Opioid antagonists (naltrexone).
- SSRIs (for example, fluoxetine)
- Atypical antipsychotics
- SNRIs (venlafaxine),
- Opioids (buprenorphine), and
- Opioid antagonists (naltrexone).
- Treatment of adults with BPD with SSRI, demonstrated abstinence from NSSI during the treatment and the 18-month follow up period. Atypical antipsychotics (such as aripiprazole and ziprasidone) resulted in reduction in rates and frequency of NSSI among self-injuring teenagers.
- Nonantipsychotics treatment in adults with BPD resulted in decrease in the rates and frequency of NSSI significantly compared with the baseline. There has been reported benefits of fluoxetine, venlafaxine, naltrexone and buprenorphine in increasing the rates of NSSI abstinence and (or) in reducing NSSI frequency.
- Combination Treatments for Nonsuicidal Self-Injury
There has been a reporting of benefits of combing CBT and antidepressants together in the treatment of major depressive disorder in adolescents
- There has been a reporting of benefits of combing CBT and antidepressants together in the treatment of major depressive disorder in adolescents
- Comprehensive Therapeutic Programs for Nonsuicidal Self-Injury
The effectiveness of comprehensive treatment programs for people with BPD or mixed personality disorders can be seen as a significant decreases in NSSI rates after intervention. These customized programs comprised pharmacotherapy, psychoeducation, group and individual therapy incorporated with DBT skills training as part of treatment.
- The effectiveness of comprehensive treatment programs for people with BPD or mixed personality disorders can be seen as a significant decreases in NSSI rates after intervention. These customized programs comprised pharmacotherapy, psychoeducation, group and individual therapy incorporated with DBT skills training as part of treatment.
- Other Interventions for Nonsuicidal Self-Injury
Following purposeful self-poisoning, a structured postcard intervention dramatically decreased suicide-related consequences.
Patients attending assertiveness training classes biweekly led by a psychiatrist improved their self-acceptance and capacity to calmly communicate their needs and desires.
Auricular acupuncture was linked to a substantial reduction in the incidence of NSSI in depressed adolescents.
- Following purposeful self-poisoning, a structured postcard intervention dramatically decreased suicide-related consequences.
- Patients attending assertiveness training classes biweekly led by a psychiatrist improved their self-acceptance and capacity to calmly communicate their needs and desires.
- Auricular acupuncture was linked to a substantial reduction in the incidence of NSSI in depressed adolescents.