Acyclovir (injection)

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# Overview
Acyclovir (injection) is an antiviral agent that is FDA approved for the treatment of herpes simplex infections in immunocompromised patients, initial episodes of herpes genitalis, herpes simplex encephalitis, neonatal herpes simplex virus infection, and varicella-zoster infections in immunocompromised patients.   Common adverse reactions include nausea, vomiting, diarrhea, abdominal pain and malaise, inflammation or phlebitis at the injection, transient elevations of serum creatinine or BUN, itching, rash, and hives.

# Adult Indications and Dosage

## FDA-Labeled Indications and Dosage (Adult)
- Acyclovir Sodium Injection is indicated for the treatment of initial and recurrent mucosal and cutaneous herpes simplex (HSV-1 and HSV-2) in immunocompromised patients.
- Acyclovir Sodium Injection is indicated for the treatment of severe initial clinical episodes of herpes genitalis in immuno-competent patients.
- Acyclovir Sodium Injection is indicated for the treatment of herpes simplex encephalitis.
- Acyclovir Sodium Injection is indicated for the treatment of neonatal herpes infections.
- Acyclovir Sodium Injection is indicated for the treatment of varicella-zoster (shingles) infections in immunocompromised patients.

### Dosing Information
- Caution - rapid or bolus intravenous injection must be avoided.
- Intramuscular or subcutaneous injection must be avoided.
- Therapy should be initiated as early as possible following onset of signs and symptoms of herpes infections.
- A maximum dose equivalent to 20 mg/kg every 8 hours should not be exceeded for any patient.
- Mucosal and cutaneous herpes simplex (HSV-1 and HSV-2)
- Infections in immunocompromised patients:
- 5 mg/kg infused at a constant rate over 1 hour, every 8 hours for 7 days.
- Severe initial clinical episodes of herpes genitalis:
- 5 mg/kg infused at a constant rate over 1 hour, every 8 hours for 5 days.
- Herpes simplex encephalitis:
- 10 mg/kg infused at a constant rate over 1 hour, every 8 hours for 10 days.
- Zoster in immunocompromised patients:
- 10 mg/kg infused at a constant rate over 1 hour, every 8 hours for 7 days.
- Obese patients should be dosed at the recommended adult dose using Ideal Body Weight.
- Patients with acute or chronic renal impairment: refer to dosage and administration section for recommended doses, and adjust the dosing interval as indicated in table 5.
- For patients who require dialysis, the mean plasma half-life of acyclovir during hemodialysis is approximately 5 hours.  This results in a 60% decrease in plasma concentrations following a six-hour dialysis period.  Therefore, the patients dosing schedule should be adjusted so that an additional dose is administered after each dialysis.
- No supplemental dose appears to be necessary after adjustment of the dosing interval.
- The calculated dose should be further diluted in an appropriate intravenous solution at a volume selected for administration during each 1 hour infusion.  Infusion concentrations of approximately 7 mg/mL or lower are recommended.  In clinical studies, the average 70 kg adult received between 60 and 150 mL of fluid per dose.  Higher concentrations (e.g., 10 mg/mL) may produce phlebitis or inflammation at the injection site upon inadvertent extravasation.  Standard, commercially available electrolyte and glucose solutions are suitable for intravenous administration; biologic or colloidal fluids (e.g., blood products, protein solutions, etc.) are not recommended.
- Once diluted for administration, each dose should be used within 24 hours.
- Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

## Off-Label Use and Dosage (Adult)

### Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Acyclovir (injection) in adult patients.

### NonGuideline-Supported Use
There is limited information regarding Off-Label NonGuideline-Supported Use of Acyclovir (injection) in adult patients.

# Pediatric Indications and Dosage

## FDA-Labeled Indications and Dosage (Pediatric)
- Mucosal and cutaneous herpes simplex (HSV-1 and HSV-2)
- Infections in immunocompromised patients:
- Adolescents (12 years of age and older):
5 mg/kg infused at a constant rate over 1 hour, every 8 hours for 7 days.
- 5 mg/kg infused at a constant rate over 1 hour, every 8 hours for 7 days.
- Pediatrics (Under 12 years of age):
10 mg/kg infused at a constant rate over 1 hour, every 8 hours for 7 days.
- 10 mg/kg infused at a constant rate over 1 hour, every 8 hours for 7 days.
- Severe initial clinical episodes of herpes genitalis:
- Adolescents (12 years of age and older):
5 mg/kg infused at a constant rate over 1 hour, every 8 hours for 5 days.
- 5 mg/kg infused at a constant rate over 1 hour, every 8 hours for 5 days.
- Herpes simplex encephalitis:
- Adolescents (12 years of age and older):
10 mg/kg infused at a constant rate over 1 hour, every 8 hours for 10 days.
- 10 mg/kg infused at a constant rate over 1 hour, every 8 hours for 10 days.
- Pediatrics (3 months to 12 years of age):
20 mg/kg infused at a constant rate over 1 hour, every 8 hours for 10 days.
- 20 mg/kg infused at a constant rate over 1 hour, every 8 hours for 10 days.
- Neonatal Herpes Simplex Virus Infections (Birth to 3 months):
- 10 mg/kg infused at a constant rate over 1 hour, every 8 hours for 10 days. In neonatal herpes simplex infections, doses of 15 mg/kg or 20 mg/kg (infused at a constant rate over 1 hour every 8 hours) have been used; the safety and efficacy of these doses are not known.
- Zoster in immunocompromised patients:
- Adolescents (12 years of age and older:
10 mg/kg infused at a constant rate over 1 hour, every 8 hours for 7 days.
- 10 mg/kg infused at a constant rate over 1 hour, every 8 hours for 7 days.
- Pediatrics (Under 12 years of age):
20 mg/kg infused at a constant rate over 1 hour, every 8 hours for 7 days.
- 20 mg/kg infused at a constant rate over 1 hour, every 8 hours for 7 days.

## Off-Label Use and Dosage (Pediatric)

### Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Acyclovir (injection) in pediatric patients.

### NonGuideline-Supported Use
There is limited information regarding Off-Label NonGuideline-Supported Use of Acyclovir (injection) in pediatric patients.

# Contraindications
- Acyclovir Sodium Injection is contraindicated for patients who develop hypersensitivity to acyclovir or valacyclovir.

# Warnings
- Acyclovir Sodium Injection is intended for intravenous infusion only, and should not be administered topically, intramuscularly, orally, subcutaneously, or in the eye.  Intravenous infusions must be given over a period of at least 1 hour to reduce the risk of renal tubular damage.
- Renal failure, in some cases resulting in death, has been observed with acyclovir therapy.  Thrombotic thrombocytopenic purpura/ hemolytic uremic syndrome (TTP/HUS), which has resulted in death, has occurred in immunocompromised patients receiving acyclovir therapy.

### PRECAUTIONS
- Precipitation of acyclovir crystals in renal tubules can occur if the maximum solubility of free acyclovir (2.5 mg/mL at 37C in water) is exceeded or if the drug is administered by bolus injection.  Ensuing renal tubular damage can produce acute renal failure.
- Abnormal renal function (decreased creatinine clearance) can occur as a result of acyclovir administration and depends on the state of the patients hydration, other treatments, and the rate of drug administration.  Concomitant use of other nephrotoxic drugs, pre-existing renal disease, and dehydration make further renal impairment with acyclovir more likely.
- Administration of acyclovir by intravenous infusion must be accompanied by adequate hydration.
- When dosage adjustments are required, they should be based on estimated creatinine clearance.
- Approximately 1% of patients receiving intravenous acyclovir have manifested encephalopathic changes characterized by either lethargy, obtundation, tremors, confusion, hallucinations, agitation, seizures, or coma.  Acyclovir should be used with caution in those patients who have underlying neurologic abnormalities and those with serious renal, hepatic, or electrolyte abnormalities, or significant hypoxia.

# Adverse Reactions

## Clinical Trials Experience
- The adverse reactions listed below have been observed in controlled and uncontrolled clinical trials in approximately 700 patients who received acyclovir at approximately 5 mg/kg (250 mg/m2) 3 times daily, and approximately 300 patients who received approximately 10 mg/kg (500 mg/m2) 3 times daily.
- The most frequent adverse reactions reported during administration of acyclovir were inflammation or phlebitis at the injection site in approximately 9% of the patients, and transient elevations of serum creatinine or BUN in 5% to 10% (the higher incidence occurred usually following rapid  intravenous infusion).  Nausea and/or vomiting occurred in approximately 7% of the patients (the majority occurring in nonhospitalized patients who received 10 mg/kg).  Itching, rash, or hives occurred in approximately 2% of patients.  Elevation of transaminases occurred in 1% to 2% of patients.
- The following hematologic abnormalities occurred at a frequency of less than 1%: anemia, neutropenia, thrombocytopenia, thrombocytosis, leukocytosis, and neutrophilia.  In addition, anorexia and hematuria were observed.
- In addition to adverse events reported from clinical trials, the following events have been identified during post-approval use of Acyclovir Sodium Injection in clinical practice.  Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made.  These events have been chosen for inclusion due to either their seriousness, frequency of reporting, potential causal connection to acyclovir, or a combination of these factors.
- Anaphylaxis, angioedema, fatigue, fever, headache, pain, peripheral edema.
- Abdominal pain, diarrhea, gastrointestinal distress, nausea.
- Hypotension.
- Disseminated intravascular coagulation, hemolysis, leukocytoclastic vasculitis, leukopenia, lymphadenopathy.
- Elevated liver function tests, hepatitis, hyperbilirubinemia, jaundice.
- Myalgia.
- Aggressive behavior, agitation, ataxia, coma, confusion, delirium, dizziness, dysathria, encephalopathy, hallucinations, obtundation, paresthesia, psychosis, seizure, somnolence, tremor.  These symptoms may be marked, particularly in older adults.
- Alopecia, erythema multiforme, photosensitive rash, pruritus, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria.  Severe local inflammatory reactions, including tissue necrosis, have occurred following infusion of acyclovir into extravascular tissues.
- Visual abnormalities.
- Renal failure, elevated blood urea nitrogen, elevated creatinine.

## Postmarketing Experience
There is limited information regarding Acyclovir (injection) Postmarketing Experience in the drug label.

# Drug Interactions
- Coadministration of probenecid with acyclovir has been shown to increase the mean acyclovir half-life and the area under the concentration-time curve.  Urinary excretion and renal clearance were correspondingly reduced.

# Use in Specific Populations

### Pregnancy
Pregnancy Category (FDA): B
- Acyclovir administered during organogenesis was not teratogenic in the mouse (450 mg/kg/day, PO), rabbit (50 mg/kg/day, SC and IV) or rat (50 mg/kg/day, SC).  These exposures resulted in plasma levels the same as, 4 and 9, and 1 and 2 times, respectively, human levels.
- There are no adequate and well-controlled studies in pregnant women.  A prospective epidemiologic registry of acyclovir use during pregnancy was established in 1984 and completed in April 1999.  There were 749 pregnancies followed in women exposed to systemic acyclovir during the first trimester of pregnancy resulting in 756 outcomes.  The occurrence rate of birth defects approximates that found in the general population.  However, the small size of the registry is insufficient to evaluate the risk for less common defects or to permit reliable or definitive conclusions regarding the safety of acyclovir in pregnant women and their developing fetuses.  Acyclovir should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Pregnancy Category (AUS): 
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Acyclovir (injection) in women who are pregnant.

### Labor and Delivery
There is no FDA guidance on use of Acyclovir (injection) during labor and delivery.

### Nursing Mothers
- Acyclovir concentrations have been documented in breast milk in two women following oral administration of acyclovir and ranged from 0.6 to 4.1 times corresponding plasma levels.  These concentrations would potentially expose the nursing infant to a dose of acyclovir up to 0.3 mg/kg/day.  Acyclovir should be administered to a nursing mother with caution and only when indicated.

### Pediatric Use
There is no FDA guidance on the use of Acyclovir (injection) in pediatric settings.

### Geriatic Use
- Clinical studies of acyclovir did not include sufficient numbers of patients aged 65 and over to determine whether they respond differently than younger patients. Other reported clinical experience has identified differences in the severity of CNS adverse events between elderly and younger patients. In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased renal function, and of concomitant disease or other drug therapy. This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function.  Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.

### Gender
There is no FDA guidance on the use of Acyclovir (injection) with respect to specific gender populations.

### Race
There is no FDA guidance on the use of Acyclovir (injection) with respect to specific racial populations.

### Renal Impairment
There is no FDA guidance on the use of Acyclovir (injection) in patients with renal impairment.

### Hepatic Impairment
There is no FDA guidance on the use of Acyclovir (injection) in patients with hepatic impairment.

### Females of Reproductive Potential and Males
There is no FDA guidance on the use of Acyclovir (injection) in women of reproductive potentials and males.

### Immunocompromised Patients
There is no FDA guidance one the use of Acyclovir (injection) in patients who are immunocompromised.

# Administration and Monitoring

### Administration
- Intravenous Infusion

### Monitoring
There is limited information regarding Acyclovir (injection) Monitoring in the drug label.

# IV Compatibility
There is limited information regarding the compatibility of Acyclovir (injection) and IV administrations.

# Overdosage
- Overdoses involving ingestions of up to 20 g have been reported.  Adverse events that have been reported in association with overdosage include agitation, coma, seizures, and lethargy.  Precipitation of acyclovir in renal tubules may occur when the solubility (2.5 mg/mL) is exceeded in the intratubular fluid.  Overdosage has been reported following bolus injections or inappropriately high doses, and in patients whose fluid and electrolyte balance were not properly monitored.  This has resulted in elevated BUN and serum creatinine, and subsequent renal failure.  In the event of acute renal failure and anuria, the patient may benefit from hemodialysis until renal function is restored.

# Pharmacology

## Mechanism of Action
- Acyclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2) and varicella-zoster virus (VZV).
- The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV.  This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue.  The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes.  In vitro, acyclovir triphosphate stops replication of herpes viral DNA.  This is accomplished in three ways: 1) competitive inhibition of viral DNA polymerase, 2) incorporation into and termination of the growing viral DNA chain, and 3) inactivation of the viral DNA polymerase.  The greater antiviral activity of acyclovir against HSV compared to VZV is due to its more efficient phosphorylation by the viral TK.

## Structure
- Acyclovir Sodium Injection is a synthetic nucleoside analog, active against herpes viruses.  It is a sterile, aqueous solution for intravenous infusion, containing 50 mg acyclovir per mL in Water for Injection, USP.  The concentration is equivalent to 54.9 mg of acyclovir sodium per mL in Water for Injection, USP.  The sodium content is approximately 5.1 mg/mL.  The pH range of the solution is 10.85 to 11.50.  Further dilution of Acyclovir Sodium Injection in an appropriate intravenous solution must be performed before infusion.
- The chemical name of acyclovir sodium is 9- guanine, and has the following structural formula:
- Acyclovir sodium is a white, crystalline powder with the molecular formula C8H10N5NaO3 and a molecular weight of 247.19.  The maximum solubility in water at 25C exceeds 100 mg/mL.  At physiologic pH, acyclovir sodium exists as the unionized form with a molecular weight of 225 and a maximum solubility in water at 37C of 2.5 mg/mL.  The pkas of acyclovir are 2.27 and 9.25.

## Pharmacodynamics
- The quantitative relationship between the in vitro susceptibility of herpes viruses to antivirals and the clinical response to therapy has not been established in humans, and virus sensitivity testing has not been standardized.  Sensitivity testing results, expressed as the concentration of drug required to inhibit by 50% the growth of virus in cell culture (IC50), vary greatly depending upon a number of factors.  Using plaque-reduction assays, the IC50 against herpes simplex virus isolates ranges from 0.02 to 13.5 mcg/mL for HSV-1 and from 0.01 to 9.9 mcg/mL for HSV-2.  The IC50 for acyclovir against most laboratory strains and clinical isolates of VZV ranges from 0.12 to 10.8 mcg/mL.  Acyclovir also demonstrates activity against the Oka vaccine strain of VZV with a mean IC50 of 1.35 mcg/mL.
- Resistance of HSV and VZV to acyclovir can result from qualitative or quantitative changes in the viral TK and/or DNA polymerase.  Clinical isolates of HSV and VZV with reduced susceptibility to acyclovir have been recovered from immunocompromised patients, especially with advanced HIV infection.  While most of the acyclovir-resistant mutants isolated thus far from such patients have been found to be TK-deficient mutants, other mutants involving the viral TK gene (TK partial and TK altered) and DNA polymerase have been isolated.  TK-negative mutants may cause severe disease in infants and immunocompromised adults.  The possibility of viral resistance to acyclovir should be considered in patients who show poor clinical response during therapy.

## Pharmacokinetics
- The pharmacokinetics of acyclovir after intravenous administration have been evaluated in adult patients with normal renal function during Phase 1/2 studies after single doses ranging from 0.5 to 15 mg/kg and after multiple doses ranging from 2.5 to 15 mg/kg every 8 hours.  Proportionality between dose and plasma levels is seen after single doses or at steady-state after multiple dosing.  Average steady-state peak and trough concentrations from 1-hour infusions administered every 8 hours are given in Table 1.
- Concentrations achieved in the cerebrospinal fluid are approximately 50% of plasma values.  Plasma protein binding is relatively low (9% to 33%) and drug interactions involving binding site displacement are not anticipated.
- Renal excretion of unchanged drug is the major route of acyclovir elimination accounting for 62% to 91% of the dose.  The only major urinary metabolite detected is 9-carboxymethoxymethylguanine accounting for up to 14.1% of the dose in patients with normal renal function.
- The half-life and total body clearance of acyclovir are dependent on renal function as shown in Table 2.

### Special Populations
- Acyclovir was administered at a dose of 2.5 mg/kg to 6 adult patients with severe renal failure.  The peak and trough plasma levels during the 47 hours preceding hemodialysis were 8.5 mcg/mL and 0.7 mcg/mL, respectively.
- Consult DOSAGE AND ADMINISTRATION section for recommended adjustments in dosing based upon creatinine clearance.
- Acyclovir pharmacokinetics were determined in 16 pediatric patients with normal renal function ranging in age from 3 months to 16 years at doses of approximately 10 mg/kg and 20 mg/kg every 8 hours (Table 3).  Concentrations achieved at these regimens are similar to those in adults receiving 5 mg/kg and 10 mg/kg every 8 hours, respectively (Table 1).  Acyclovir pharmacokinetics were determined in 12 patients ranging in age from birth to 3 months at doses of 5 mg/kg, 10 mg/kg, and 15 mg/kg every 8 hours (Table 3).
- Acyclovir plasma concentrations are higher in geriatric patients compared to younger adults, in part due to age-related changes in renal function.  Dosage reduction may be required in geriatric patients with underlying renal impairment (see PRECAUTIONS, GERIATRIC USE).
- Coadministration of probenecid with acyclovir has been shown to increase the mean acyclovir half-life and the area under the concentration-time curve.  Urinary excretion and renal clearance were correspondingly reduced.

## Nonclinical Toxicology
- The data presented below include references to peak steady-state plasma acyclovir concentrations observed in humans treated with 30 mg/kg/day (10 mg/kg every 8 hours, dosing appropriate for treatment of herpes zoster or herpes encephalitis), or 15 mg/kg/day (5 mg/kg every 8 hours, dosing appropriate for treatment of primary genital herpes or herpes simplex infections in immunocompromised patients).  Plasma drug concentrations in animal studies are expressed as multiples of human exposure to acyclovir at the higher and lower dosing schedules.
- Acyclovir was tested in lifetime bioassays in rats and mice at single daily doses of up to 450 mg/kg administered by gavage.  There was no statistically significant difference in the incidence of tumors between treated and control animals, nor did acyclovir shorten the latency of tumors.  At 450 mg/kg/day, plasma concentrations in both the mouse and rat bioassay were lower than concentrations in humans.
- Acyclovir was tested in 16 in vitro and in vivo genetic toxicity assays.  Acyclovir was positive in 5 of the assays.
- Acyclovir did not impair fertility or reproduction in mice (450 mg/kg/day, PO) or in rats (25 mg/kg/day, SC).  In the mouse study, plasma levels were the same as human levels, while in the rat study, they were 1 to 2 times human levels.  At higher doses (50 mg/kg/day, SC) in rats and rabbits (1 to 2 and 1 to 3 times human levels, respectively) implantation efficacy, but not litter size, was decreased.  In a rat peri- and post-natal study at 50 mg/kg/day, SC, there was a statistically significant decrease in group mean numbers of corpora lutea, total implantation sites, and live fetuses.
- No testicular abnormalities were seen in dogs given 50 mg/kg/day, IV for 1 month (1 to 3 times human levels) or in dogs given 60 mg/kg/day orally for 1 year (the same as human levels).  Testicular atrophy and aspermatogenesis were observed in rats and dogs at higher dose levels.

# Clinical Studies
- A multicenter trial of acyclovir at a dose of 250 mg/m2 every 8 hours (750 mg/m2/day) for 7 days was conducted in 98 immunocompromised patients (73 adults and 25 children) with orofacial, esophageal, genital and other localized infections (52 treated with acyclovir and 46 with placebo).  Acyclovir decreased virus excretion, reduced pain, and promoted healing of lesions.
- In placebo-controlled trials, 58 patients with initial genital herpes were treated with intravenous acyclovir 5 mg/kg or placebo (27 patients treated with acyclovir and 31 treated with placebo) every 8 hours for 5 days.  Acyclovir decreased the duration of viral excretion, new lesion formation, and duration of vesicles, and promoted healing of lesions.
- Sixty-two patients ages 6 months to 79 years with brain biopsy-proven herpes simplex encephalitis were randomized to receive either acyclovir (10 mg/kg every 8 hours) or vidarabine (15 mg/kg/day) for 10 days (28 were treated with acyclovir and 34 with vidarabine).  Overall mortality at 12 months for patients treated with acyclovir was 25% compared to 59% for patients treated with vidarabine.  The proportion of patients treated with acyclovir functioning normally or with only mild sequelae (e.g., decreased attention span) was 32% compared to 12% of patients treated with vidarabine.
- Patients less than 30 years of age and those who had the least severe neurologic involvement at time of entry into study had the best outcome with treatment with acyclovir.  An additional controlled study performed in Europe demonstrated similar findings.
- Two hundred and two infants with neonatal herpes simplex infections were randomized to receive either acyclovir 10 mg/kg every 8 hours (n=107) or vidarabine 30 mg/kg/day (n=95) for 10 days.  Outcomes are presented in Table 4.
- Rates of neurologic sequelae at 1 year were comparable between the treatment groups.
- A multicenter trial of acyclovir at a dose of 500 mg/m2 every 8 hours for 7 days was conducted in immunocompromised patients with zoster infections (shingles).  Ninety-four (94) patients were evaluated (52 patients were treated with acyclovir and 42 with placebo).  Acyclovir was superior to placebo as measured by reductions in cutaneous dissemination and visceral dissemination.

# How Supplied
Acyclovir Sodium Injection is available as:
Discard unused portion.
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## Storage
- Store at 20 to 25C (68 to 77F.

# Images

## Drug Images

## Package and Label Display Panel
NDC 63323-325-24
PRX302520
Acyclovir Sodium Injection
1,000 mg per 20 mL-  (50 mg per mL)
For IV Infusion Only
Must Be Diluted Prior To Use
20 mL Single Dose Vial
Rx only
NDC 63323-325-24
PRX302520
Acyclovir Sodium Injection
1,000 mg per 20 mL-  (50 mg per mL)
For IV Infusion Only
Must Be Diluted Prior To Use
20 mL Single Dose Vial
10 Vials
Rx only

# Patient Counseling Information
There is limited information regarding Acyclovir (injection) Patient Counseling Information in the drug label.

# Precautions with Alcohol
Alcohol-Acyclovir (injection) interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

# Brand Names
- Zovirax
- Sitavig 

# Look-Alike Drug Names
There is limited information regarding Acyclovir (injection) Look-Alike Drug Names in the drug label.

# Drug Shortage Status

# Price