Chromosome 16 (human)
Chromosome 16 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 16 spans about 90 million base pairs (the building material of DNA) and represents just under 3% of the total DNA in cells.
In February 2010, a new cause of obesity due to a microdeletion on chromosome 16 was announced. It may explain about 1% of obesity cases.  Research showed that this microdeletion is relatively common in obese people but lacking in most non-obese people.

# Genes
The following are some of the gene count estimates of human chromosome 16. Because researchers use different approaches to genome annotation their predictions of the number of genes on each chromosome varies (for technical details, see gene prediction). Among various projects, the collaborative consensus coding sequence project (CCDS) takes an extremely conservative strategy. So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.
The following are some of the genes located on chromosome 16:
- ACSF3: encoding enzyme Acyl-CoA synthetase family member 3
- ACSM2B: encoding enzyme Acyl-coenzyme A synthetase ACSM2B, mitochondrial
- ACSM3: encoding enzyme Acyl-coenzyme A synthetase ACSM3, mitochondrial 2
- ADHD1: Attention deficit-hyperactivity disorder, susceptibility to, 1
- ARL6IP1: encoding protein ADP-ribosylation factor-like protein 6-interacting protein 1
- ARMC5
- BMIQ5: Body mass index quantitative trait locus 5
- C16orf13/JFP2: encoding protein Chromosome 16 open reading frame 13
- C16orf42: encoding ] FALSE
- C16orf58: encoding protein Chromosome 16 open reading frame 58
- C16orf62: encoding protein Chromosome 16 open reading frame 62
- C16orf71: encoding protein Uncharacterized protein Chromosome 16 Open Reading Frame 71
- C16orf84:
- C16orf95:
- C16orf96:
- C16orf96: encoding protein C16orf96, or chromosome 16 open reading frame 96,
- CARHSP1: Calcium-regulated heat stable protein 1
- CASP16P: encoding protein Caspase 16, pseudogene
- CCDC113: encoding protein Coiled-coil domain-containing protein 113
- Ccdc78: encoding protein Coiled-coil domain-containing 78 (CCDC78)
- CDIPT: CDP-diacylglycerol-inositol 3-phosphatidyltransferase
- CFDP1: Craniofacial development protein 1
- CHDS1: Coronary heart disease, susceptibility to, 1
- CIAPIN1: Anamorsin (originally, Cytokine induced apoptosis inhibitor 1)
- CKLF: Chemokine-like factor
- CLUAP1:
- CMTM2: encoding protein CKLF-like MARVEL transmembrane domain-containing protein 2
- CCDC135: encoding protein Coiled-coil domain-containing protein 135
- COTL1: encoding protein Coactosin-like protein
- CTRL: Chymotrypsin-like protease
- DCTPP1: encoding enzyme dCTP pyrophosphatase 1
- DEL16p13.3, RSTSS: Chromosome 16p13.3 deletion syndrome (Rubinstein-Taybi deletion syndrome)
- DHX38: DEAH-box helicase 38
- DUP16p13.3, C16DUPq13.3: Chromosome 16p13.3 duplication syndrome
- EMP2: Epithelial membrane protein 2
- ENKD1: Enkurin domain-containing protein 1
- ERAF: Alpha-hemoglobin-stabilizing protein
- FAHD1: Fumarylacetoacetate hydrolase domain-containing protein 1
- FAM57B: Family with sequence similarity 57 member B
- FBRS: Probably fibrosin-1 long transcript protein
- FOXC2-AS1: encoding protein FOXC2 antisense RNA 1
- GLG1: Golgi apparatus protein 1
- HBAP1: Hemoglobin, alpha pseudogene 1
- HBHR, ATR1: Alpha-thalassemia/mental retardation syndrome, type 1
- HIRIP3: encoding protein HIRA-interacting protein 3
- HN1L: encoding protein Hematological and neurological expressed 1-like protein
- IBD8: Inflammatory bowel disease 8
- IHPS2: Pyloric stenosis, infantile hypertrophic, 2
- ITFG3: encoding protein Protein ITFG3
- KDM8: encoding protein Lysine demethylase 8
- LINC00273 encoding protein Long intergenic non-protein coding RNA 273
- LOC124220: encoding protein Zymogen granule protein 16 homolog B
- LOC81691:
- LUC7L: encoding protein Putative RNA-binding protein Luc7-like 1
- LYPLA3: encoding enzyme Group XV phospholipase A2
- MC1R: melanocortin 1 receptor
- MCOPCT1: Microphthalmia with cataract 1
- MT1G: encoding protein Metallothionein-1G
- METRN: encoding protein Meteorin, glial cell differentiation regulator
- MKL2: encoding protein MKL/myocardin-like protein 2
- MPHOSPH6: encoding enzyme M-phase phosphoprotein 6
- MT1X: encoding protein Metallothionein 1X
- NIP30: encoding protein NIP30 protein
- NOB1: encoding protein RNA-binding protein NOB1
- NOMO1: encoding protein Nodal modulator 1
- NPW: encoding protein Neuropeptide W
- NUBP2: encoding protein Nucleotide-binding protein 2
- NUPR1: encoding protein Nuclear protein 1
- OGFOD1:
- PDF: encoding enzyme Peptide deformylase, mitochondrial
- PDPR: encoding protein Pyruvate dehydrogenase phosphatase regulatory subunit
- PKDTS: Polycystic kidney disease, infantile severe, with tuberous sclerosis
- PMFBP1: encoding protein Polyamine-modulated factor 1-binding protein 1
- POLR3K: encoding enzyme DNA-directed RNA polymerase III subunit RPC10
- PRR35: encoding protein Proline rich 35
- RPS15A: encoding protein 40S ribosomal protein S15a
- RSL1D1: encoding protein Ribosomal L1 domain-containing protein 1
- SHCBP1: encoding protein SHC SH2 domain-binding protein 1
- SLZ1: encoding protein SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
- SNAI3-AS1: encoding protein SNAI3 antisense RNA 1
- SNORD71: encoding protein Small nucleolar RNA, C/D box 71
- SPSB3: encoding protein SplA/ryanodine receptor domain and SOCS box containing 3
- SRCAP: encoding enzyme Helicase SRCAP
- TANGO6: encoding protein Transport and Golgi organization protein 6 homolog
- TBC1D24: encoding protein TBC1 domain family, member 24
- TELO2: encoding protein Telomere length regulation protein TEL2 homolog
- TMEM112: encoding enzyme Lipase maturation factor 1
- TMEM8A: encoding protein Transmembrane protein 8A
- TNRC6A: encoding protein Trinucleotide repeat-containing gene 6A protein
- Tuberous sclerosis complex tumor suppressors: encoding ] FALSE
- UNKL: encoding protein RING finger protein unkempt-like
- VAT1L: encoding protein Vesicle amine transport protein 1 homolog (T. californica)-like
- ZG16
- ZNF23: encoding protein Zinc finger protein 23
- ZNF200: encoding protein Zinc finger protein 200
- ZNF263: encoding protein Zinc finger protein 263
- ZNF629: encoding protein Zinc finger protein 629

# Diseases and disorders
- Trisomy 16
- Familial Mediterranean fever (FMF)
- Thalassemia
- Autosomal dominant polycystic kidney disease (PKD-1)
- Asperger syndrome
- Schizophrenia
- Attention deficit hyperactivity disorder  (ADHD)
- Synesthesia

# Associated traits
- Red hair

# Cytogenetic band