Hematologic disease
Hematologic diseases are disorders which primarily affect the blood.

# Classification of hematologic diseases
- Hemoglobinopathies (congenital abnormality of the hemoglobin molecule or of the rate of hemoglobin synthesis)
Sickle-cell disease
Thalassemia
Methemoglobinemia
- Sickle-cell disease
- Thalassemia
- Methemoglobinemia
- Anemias (lack of red blood cells or hemoglobin)
Iron deficiency anemia
Megaloblastic anemia
Vitamin B12 deficiency
Pernicious anemia
Folate deficiency
Hemolytic anemias (destruction of red blood cells)
Genetic disorders of RBC membrane
Hereditary spherocytosis
Hereditary elliptocytosis
Genetic disorders of RBC metabolism
Glucose-6-phosphate dehydrogenase deficiency (G6PD)
Pyruvate kinase deficiency
Immune mediated hemolytic anaemia (direct Coombs test is positive)
Autoimmune hemolytic anemia
Warm antibody autoimmune hemolytic anemia
Idiopathic
Systemic lupus erythematosus (SLE)
Evans' syndrome (antiplatelet antibodies and haemolytic antibodies)
Cold antibody autoimmune hemolytic anemia
Idiopathic cold hemagglutinin syndrome
Infectious mononucleosis
Paroxysmal cold hemoglobinuria (rare)
Alloimmune hemolytic anemia
Hemolytic disease of the newborn (HDN)
Rh disease (Rh D)
ABO hemolytic disease of the newborn
Anti-Kell hemolytic disease of the newborn
Rhesus c hemolytic disease of the newborn
Rhesus E hemolytic disease of the newborn
Other blood group incompatibility (RhC, Rhe, Kid, Duffy, MN, P and others)
Drug induced immune mediated hemolytic anaemia
Penicillin (high dose)
Methyldopa
Hemoglobinopathies (where these is an unstable or crystalline hemoglobin)
Paroxysmal nocturnal hemoglobinuria (rare acquired clonal disorder of red blood cell surface proteins)
Direct physical damage to RBCs
Microangiopathic hemolytic anemia
Secondary to artificial heart valve(s)
Aplastic anemia
Fanconi anemia
Diamond-Blackfan anemia
Acquired pure red cell aplasia
- Iron deficiency anemia
- Megaloblastic anemia
Vitamin B12 deficiency
Pernicious anemia
Folate deficiency
- Vitamin B12 deficiency
Pernicious anemia
- Pernicious anemia
- Folate deficiency
- Hemolytic anemias (destruction of red blood cells)
Genetic disorders of RBC membrane
Hereditary spherocytosis
Hereditary elliptocytosis
Genetic disorders of RBC metabolism
Glucose-6-phosphate dehydrogenase deficiency (G6PD)
Pyruvate kinase deficiency
Immune mediated hemolytic anaemia (direct Coombs test is positive)
Autoimmune hemolytic anemia
Warm antibody autoimmune hemolytic anemia
Idiopathic
Systemic lupus erythematosus (SLE)
Evans' syndrome (antiplatelet antibodies and haemolytic antibodies)
Cold antibody autoimmune hemolytic anemia
Idiopathic cold hemagglutinin syndrome
Infectious mononucleosis
Paroxysmal cold hemoglobinuria (rare)
Alloimmune hemolytic anemia
Hemolytic disease of the newborn (HDN)
Rh disease (Rh D)
ABO hemolytic disease of the newborn
Anti-Kell hemolytic disease of the newborn
Rhesus c hemolytic disease of the newborn
Rhesus E hemolytic disease of the newborn
Other blood group incompatibility (RhC, Rhe, Kid, Duffy, MN, P and others)
Drug induced immune mediated hemolytic anaemia
Penicillin (high dose)
Methyldopa
Hemoglobinopathies (where these is an unstable or crystalline hemoglobin)
Paroxysmal nocturnal hemoglobinuria (rare acquired clonal disorder of red blood cell surface proteins)
Direct physical damage to RBCs
Microangiopathic hemolytic anemia
Secondary to artificial heart valve(s)
- Genetic disorders of RBC membrane
Hereditary spherocytosis
Hereditary elliptocytosis
- Hereditary spherocytosis
- Hereditary elliptocytosis
- Genetic disorders of RBC metabolism
Glucose-6-phosphate dehydrogenase deficiency (G6PD)
Pyruvate kinase deficiency
- Glucose-6-phosphate dehydrogenase deficiency (G6PD)
- Pyruvate kinase deficiency
- Immune mediated hemolytic anaemia (direct Coombs test is positive)
Autoimmune hemolytic anemia
Warm antibody autoimmune hemolytic anemia
Idiopathic
Systemic lupus erythematosus (SLE)
Evans' syndrome (antiplatelet antibodies and haemolytic antibodies)
Cold antibody autoimmune hemolytic anemia
Idiopathic cold hemagglutinin syndrome
Infectious mononucleosis
Paroxysmal cold hemoglobinuria (rare)
Alloimmune hemolytic anemia
Hemolytic disease of the newborn (HDN)
Rh disease (Rh D)
ABO hemolytic disease of the newborn
Anti-Kell hemolytic disease of the newborn
Rhesus c hemolytic disease of the newborn
Rhesus E hemolytic disease of the newborn
Other blood group incompatibility (RhC, Rhe, Kid, Duffy, MN, P and others)
Drug induced immune mediated hemolytic anaemia
Penicillin (high dose)
Methyldopa
- Autoimmune hemolytic anemia
Warm antibody autoimmune hemolytic anemia
Idiopathic
Systemic lupus erythematosus (SLE)
Evans' syndrome (antiplatelet antibodies and haemolytic antibodies)
Cold antibody autoimmune hemolytic anemia
Idiopathic cold hemagglutinin syndrome
Infectious mononucleosis
Paroxysmal cold hemoglobinuria (rare)
- Warm antibody autoimmune hemolytic anemia
Idiopathic
Systemic lupus erythematosus (SLE)
Evans' syndrome (antiplatelet antibodies and haemolytic antibodies)
- Idiopathic
- Systemic lupus erythematosus (SLE)
- Evans' syndrome (antiplatelet antibodies and haemolytic antibodies)
- Cold antibody autoimmune hemolytic anemia
Idiopathic cold hemagglutinin syndrome
Infectious mononucleosis
Paroxysmal cold hemoglobinuria (rare)
- Idiopathic cold hemagglutinin syndrome
- Infectious mononucleosis
- Paroxysmal cold hemoglobinuria (rare)
- Alloimmune hemolytic anemia
Hemolytic disease of the newborn (HDN)
Rh disease (Rh D)
ABO hemolytic disease of the newborn
Anti-Kell hemolytic disease of the newborn
Rhesus c hemolytic disease of the newborn
Rhesus E hemolytic disease of the newborn
Other blood group incompatibility (RhC, Rhe, Kid, Duffy, MN, P and others)
- Hemolytic disease of the newborn (HDN)
Rh disease (Rh D)
ABO hemolytic disease of the newborn
Anti-Kell hemolytic disease of the newborn
Rhesus c hemolytic disease of the newborn
Rhesus E hemolytic disease of the newborn
Other blood group incompatibility (RhC, Rhe, Kid, Duffy, MN, P and others)
- Rh disease (Rh D)
- ABO hemolytic disease of the newborn
- Anti-Kell hemolytic disease of the newborn
- Rhesus c hemolytic disease of the newborn
- Rhesus E hemolytic disease of the newborn
- Other blood group incompatibility (RhC, Rhe, Kid, Duffy, MN, P and others)
- Drug induced immune mediated hemolytic anaemia
Penicillin (high dose)
Methyldopa
- Penicillin (high dose)
- Methyldopa
- Hemoglobinopathies (where these is an unstable or crystalline hemoglobin)
- Paroxysmal nocturnal hemoglobinuria (rare acquired clonal disorder of red blood cell surface proteins)
- Direct physical damage to RBCs
Microangiopathic hemolytic anemia
Secondary to artificial heart valve(s)
- Microangiopathic hemolytic anemia
- Secondary to artificial heart valve(s)
- Aplastic anemia
Fanconi anemia
Diamond-Blackfan anemia
Acquired pure red cell aplasia
- Fanconi anemia
- Diamond-Blackfan anemia
- Acquired pure red cell aplasia
- Decreased numbers of cells
Myelodysplastic syndrome
Myelofibrosis
Neutropenia (decrease in the number of neutrophils)
Agranulocytosis
Glanzmann's thrombasthenia
Thrombocytopenia (decrease in the number of platelets)
Idiopathic thrombocytopenic purpura (ITP)
Thrombotic thrombocytopenic purpura (TTP)
Heparin-induced thrombocytopenia (HIT)
- Myelodysplastic syndrome
- Myelofibrosis
- Neutropenia (decrease in the number of neutrophils)
- Agranulocytosis
- Glanzmann's thrombasthenia
- Thrombocytopenia (decrease in the number of platelets)
Idiopathic thrombocytopenic purpura (ITP)
Thrombotic thrombocytopenic purpura (TTP)
Heparin-induced thrombocytopenia (HIT)
- Idiopathic thrombocytopenic purpura (ITP)
- Thrombotic thrombocytopenic purpura (TTP)
- Heparin-induced thrombocytopenia (HIT)
- Myeloproliferative disorders (Increased numbers of cells)
Polycythemia vera (increase in the number of cells in general)
Leukocytosis (increase in the number of white blood cells)
Thrombocytosis (increase in the number of platelets)
Myeloproliferative disorder
- Polycythemia vera (increase in the number of cells in general)
- Leukocytosis (increase in the number of white blood cells)
- Thrombocytosis (increase in the number of platelets)
- Myeloproliferative disorder
- Hematological malignancies
Lymphomas
Hodgkin's disease
Non-Hodgkin's lymphoma{includes the next eight entries}
Burkitt's lymphoma
Anaplastic large cell lymphoma
Splenic marginal zone lymphoma
Hepatosplenic T-cell lymphoma
Angioimmunoblastic T-cell lymphoma (AILT)
Myelomas
Multiple myeloma
Waldenstrom macroglobulinemia
Plasmacytoma
Leukemias
Acute lymphocytic leukemia (ALL)
Chronic lymphocytic leukemia (CLL){now included in theCLL/SCLL type NHL}
Acute myelogenous leukemia (AML)
Chronic myelogenous leukemia (CML)
T-cell prolymphocytic leukemia (T-PLL)
B-cell prolymphocytic leukemia (B-PLL)
Chronic neutrophilic leukemia (CNL)
Hairy cell leukemia (HCL)
T-cell large granular lymphocyte leukemia (T-LGL)
Aggressive NK-cell leukemia
- Lymphomas
Hodgkin's disease
Non-Hodgkin's lymphoma{includes the next eight entries}
Burkitt's lymphoma
Anaplastic large cell lymphoma
Splenic marginal zone lymphoma
Hepatosplenic T-cell lymphoma
Angioimmunoblastic T-cell lymphoma (AILT)
- Hodgkin's disease
- Non-Hodgkin's lymphoma{includes the next eight entries}
- Burkitt's lymphoma
- Anaplastic large cell lymphoma
- Splenic marginal zone lymphoma
- Hepatosplenic T-cell lymphoma
- Angioimmunoblastic T-cell lymphoma (AILT)
- Myelomas
Multiple myeloma
Waldenstrom macroglobulinemia
- Multiple myeloma
- Waldenstrom macroglobulinemia
- Plasmacytoma
- Leukemias
Acute lymphocytic leukemia (ALL)
Chronic lymphocytic leukemia (CLL){now included in theCLL/SCLL type NHL}
Acute myelogenous leukemia (AML)
Chronic myelogenous leukemia (CML)
T-cell prolymphocytic leukemia (T-PLL)
B-cell prolymphocytic leukemia (B-PLL)
Chronic neutrophilic leukemia (CNL)
Hairy cell leukemia (HCL)
T-cell large granular lymphocyte leukemia (T-LGL)
Aggressive NK-cell leukemia
- Acute lymphocytic leukemia (ALL)
- Chronic lymphocytic leukemia (CLL){now included in theCLL/SCLL type NHL}
- Acute myelogenous leukemia (AML)
- Chronic myelogenous leukemia (CML)
- T-cell prolymphocytic leukemia (T-PLL)
- B-cell prolymphocytic leukemia (B-PLL)
- Chronic neutrophilic leukemia (CNL)
- Hairy cell leukemia (HCL)
- T-cell large granular lymphocyte leukemia (T-LGL)
- Aggressive NK-cell leukemia
- Coagulopathies (disorders of bleeding and coagulation)
Thrombocytosis
Recurrent thrombosis
Disseminated intravascular coagulation
Disorders of clotting proteins
Hemophilia
Hemophilia A
Hemophilia B (also known as Christmas disease)
Hemophilia C
Von Willebrand disease
Disseminated intravascular coagulation
Protein S deficiency
Antiphospholipid syndrome
Disorders of platelets
Thrombocytopenia
Glanzmann's thrombasthenia
Wiskott-Aldrich syndrome
- Thrombocytosis
- Recurrent thrombosis
- Disseminated intravascular coagulation
- Disorders of clotting proteins
Hemophilia
Hemophilia A
Hemophilia B (also known as Christmas disease)
Hemophilia C
Von Willebrand disease
Disseminated intravascular coagulation
Protein S deficiency
Antiphospholipid syndrome
- Hemophilia
Hemophilia A
Hemophilia B (also known as Christmas disease)
Hemophilia C
- Hemophilia A
- Hemophilia B (also known as Christmas disease)
- Hemophilia C
- Von Willebrand disease
- Disseminated intravascular coagulation
- Protein S deficiency
- Antiphospholipid syndrome
- Disorders of platelets
Thrombocytopenia
Glanzmann's thrombasthenia
Wiskott-Aldrich syndrome
- Thrombocytopenia
- Glanzmann's thrombasthenia
- Wiskott-Aldrich syndrome
- Miscellaneous
Haemochromatosis
Asplenia
Hypersplenism
Gauchers disease
Monoclonal gammopathy of undetermined significance
- Haemochromatosis
- Asplenia
- Hypersplenism
Gauchers disease
- Gauchers disease
- Monoclonal gammopathy of undetermined significance
- Hematological changes secondary to non-hematological disorders
Anemia of chronic disease
Infectious mononucleosis
AIDS
Malaria
Leishmaniasis
- Anemia of chronic disease
- Infectious mononucleosis
- AIDS
- Malaria
- Leishmaniasis