Brazilian practice guidelines for stroke rehabilitation: part II



# Introduction
Stroke causes significant brain tissue damage and multiple neurological impairments, leading to a significant loss of function and residual disability. [bib_ref] Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives, Kuriakose [/bib_ref] The main goal of stroke rehabilitation is to organize and optimize the process of recovery, enabling a person to achieve their optimal physical, cognitive, communicative, emotional, and social levels of functioning through the integration of interdisciplinary rehabilitative techniques. [bib_ref] Stroke rehabilitation, Langhorne [/bib_ref] In stroke recovery, it is necessary to consider the greater improvement that occurs in the first three months. [bib_ref] The hemiplegic arm after stroke: measurement and recovery, Wade [/bib_ref] During this phase, variable spontaneous neurological improvement can be considered a confounder in the assessment of the rehabilitation intervention. [bib_ref] The hemiplegic arm after stroke: measurement and recovery, Wade [/bib_ref] However, progress in functional outcomes after three months seems to be largely dependent on learning adaptation strategies. [bib_ref] Impact of time on improvement of outcome after stroke, Kwakkel [/bib_ref] Improvement probably occurs through a complex combination of spontaneous recovery and learning-dependent processes, including restitution, substitution, and compensation. [bib_ref] Impact of time on improvement of outcome after stroke, Kwakkel [/bib_ref] Neurological repair probably occurs through brain reorganization, leading to true recovery associated with compensation and restitution in the later phases after stroke. [bib_ref] Understanding the pattern of functional recovery after stroke: facts and theories, Kwakkel [/bib_ref] Active, functional, and independent movement contribute to the brain reorganiza-tion after stroke and could be a key component in motor learning and rehabilitation. [bib_ref] Motor learning: its relevance to stroke recovery and neurorehabilitation, Krakauer [/bib_ref] [bib_ref] What is the evidence for physical therapy poststroke? A systematic review and..., Veerbeek [/bib_ref] The purpose of the Brazilian Practice Guidelines for Stroke Rehabilitation -Part II is to guide health professionals working in stroke rehabilitation with evidence from the most recent studies available. Brazilian versions of outcome measures used in stroke rehabilitation are presented in the Supplementary Material. The literature on interventions for each impairment and disability situation is presented, followed by practical recommendations. The classification of recommendation rating and level of evidence used in Part I was followed.The main challenge in developing this guideline was the heterogeneity and paucity of high-quality evidence to support intervention recommendations. Some meta-analyses of each intervention were based on low-or very low-quality evidence due to unclear or high risk of bias and the recruitment of small samples. [bib_ref] What is the evidence for physical therapy poststroke? A systematic review and..., Veerbeek [/bib_ref] Following the same methods used to write Part I, the members of the Scientific Department of Neurological Rehabilitation of the Brazilian Academy of Neurology participated in online discussion forums with predefined topics, followed by videoconference meetings in which controversies were discussed, leading to a consensus. For the preparation of the Brazilian Practice Guidelines for Stroke Rehabilitation, several national coauthors were asked to write the suggested topics following criteria defined by the guideline coordinators. The present work focuses on recent clinical trials, meta-analyses, and systematic reviews in the literature on stroke rehabilitation.

## Recommendation rating and level of evidence recommendations
- Class I: There is evidence and/or consensus that the intervention is effective;
- Class II: There is conflicting evidence and/or divergence of opinions about the effectiveness and usefulness of the intervention:
-IIa: Although there is divergent evidence on the usefulness and effectiveness of the intervention, the recommendations are in favor of the intervention; -IIb: Utility and effectiveness are less established by the evidence or opinions;
- Class III: There is evidence and/or consensus that the intervention is not useful or effective and may cause harm.
Level of evidence A
- A: Data are obtainded from multiple randomized clinical trials. - B: Data are obtained from a single randomized or nonrandomized study. - C: Consensus and expert opnions, case studies, or standart treatments.
A Recommendations of systematic reviews and meta-analyses based on very low-to low-quality evidence were classified as level "B" of evidence.

## Disorders of communication: aphasia, dysarthria, and apraxia of speech
The incidence of aphasia and dysarthria after a first stroke is of approximately 30% and 42% respectively. [bib_ref] Poststroke Aphasia Frequency, Recovery, and Outcomes: A Systematic Review and Meta-Analysis, Flowers [/bib_ref] Regarding the survivors six months poststroke, 35% remain aphasic and 57%, dysarthric. [bib_ref] Poststroke Aphasia Frequency, Recovery, and Outcomes: A Systematic Review and Meta-Analysis, Flowers [/bib_ref] The presence of apraxia of speech (AOS) alone is rare, co-occurring with aphasia in $ 30% of the cases. Aphasia is associated with a longer hospital stay and greater mortality and morbidity. Disorders of aphasia, AOS, and dysarthria negatively impact the ability to work, lead to social withdrawal, and increase the risk of developing anxiety and depression. Speech and language therapy is indicated for all patients with aphasia. A systematic review demonstrated that access to speech and language therapy benefits the functional use of language, language comprehension (listening or reading), and language production (speaking or writing) when compared with no access to therapy.Furthermore, functional communication was significantly better in people with aphasia submitted to therapy at a high intensity, high dose, or over a long period compared with those submitted to therapy at a lower intensity, lower dose, or over a shorter period.There is a consensus that intervention should start early.However, a recent prospective, randomized, singleblinded trial 11 aimed to determine whether intensive aphasia therapy, beginning within 14 days after stroke, improved communication recovery. The authors 11 found that early, intensive aphasia therapy did not improve communication recovery within 12 weeks poststroke compared with usual care. However, they 11 pointed out that most participants, regardless of group allocation, achieved significant clinical gains in language recovery.
Regarding AOS, the articulatory-kinematic approach is the most used, studied, and recommended to improve speech sound accuracy. [bib_ref] Treatment for Acquired Apraxia of Speech: A Systematic Review of Intervention Research..., Ballard [/bib_ref] Speech therapy also positively affects the recovery of patients with dysarthria. 13 A metaanalysis 14 of patients with poststroke dysarthria showed that the alternating and sequential motion rate and maximum phonation time improved significantly after speech rehabilitation.
The evidence that repetitive transcranial magnetic stimulation (rTMS) with transcranial direct current stimulation (tDCS) is effective in the treatment of aphasia is of low to moderate quality. [bib_ref] Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS):..., Lefaucheur [/bib_ref] [bib_ref] Transcranial direct current stimulation (tDCS) for improving aphasia after stroke: a systematic..., Elsner [/bib_ref] [bib_ref] An update on medications and noninvasive brain stimulation to augment language rehabilitation..., Saxena [/bib_ref] [bib_ref] Repetitive transcranial magnetic stimulation for management of poststroke impairments: An overview of..., Kim [/bib_ref] [bib_ref] Is There a Future for Noninvasive Brain Stimulation as a Therapeutic Tool?, Terranova [/bib_ref] Low frequency rTMS applied over the right inferior frontal gyrus is probably effective in promoting the recovery of non-fluent aphasics in the chronic stage of stroke, especially if used in combination with speech and language therapy. [bib_ref] Low-frequency rTMS of the unaffected hemisphere in stroke patients: A systematic review, Sebastianelli [/bib_ref] Anodal tDCS applied over the left inferior frontal gyrus is supported by evidence of moderate quality for its efficacy in the naming of nouns, but not verbs, in nonfluent aphasics in the chronic phases of stroke, with possible maintenance of gains during follow-up. [bib_ref] Low-frequency rTMS of the unaffected hemisphere in stroke patients: A systematic review, Sebastianelli [/bib_ref] Few studies on apraxia of speech and dysarthria have been conducted, and those available only involve small samples.
The positive results reported in meta-analyses and systematic reviews do not necessarily reflect meaningful clinical benefits. [bib_ref] Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS):..., Lefaucheur [/bib_ref] Differences in the methodologies employed to analyze study data lead to different levels of evidence. [bib_ref] Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS):..., Lefaucheur [/bib_ref] Patient responses to stimuli vary greatly due to individual factors and different mechanisms of functional reorganization of the brain following stroke, which are poorly understood. [bib_ref] Is There a Future for Noninvasive Brain Stimulation as a Therapeutic Tool?, Terranova [/bib_ref] The strategy of applying inhibitory or excitatory stimuli to the left or right hemispheres may not be the optimal approach, and the best site and paradigm for stimulation must first be determined. [bib_ref] Transcranial direct current stimulation (tDCS) for improving aphasia after stroke: a systematic..., Elsner [/bib_ref] The evidence supporting the benefits of rTMS and tDCS is preliminary, and there is no consensus on the therapeutic use of these techniques in the clinical practice. [bib_ref] Transcranial direct current stimulation (tDCS) for improving aphasia after stroke: a systematic..., Elsner [/bib_ref] [bib_ref] An update on medications and noninvasive brain stimulation to augment language rehabilitation..., Saxena [/bib_ref] [bib_ref] Repetitive transcranial magnetic stimulation for management of poststroke impairments: An overview of..., Kim [/bib_ref] [bib_ref] Is There a Future for Noninvasive Brain Stimulation as a Therapeutic Tool?, Terranova [/bib_ref] Regarding the pharmacological approach, donepezil and memantine have been shown to improve several aspects of language; 21 the effects of galantamine, amphetamines, and levodopa remain inconclusive; bromocriptine demonstrated no benefits, 21 whereas piracetam promoted a transient limited effect. 22

## Recommendations
- Speech and language therapy should be started early for all poststroke patients with aphasia (Recommendation I-A);
Arquivos de Neuro-Psiquiatria Vol. 80 No. 7/2022  2022. Academia Brasileira de Neurologia. All rights reserved.
- The effectiveness of combined early and intensive aphasia therapy is uncertain (Recommendation IIb-A); - For AOS, an articulatory-kinematic approach is recommended (Recommendation IIa-A); - Speech therapy is indicated for dysarthria rehabilitation (Recommendation IIa-A); - The benefits of rTMS and tDCS in poststroke aphasia rehabilitation are uncertain (Recommendation IIb-A), as well as in AOS and dysarthria rehabilitation (Recommendation IIb-C); - Donepezil and memantine can be used for poststroke aphasia treatment (Recommendation IIa-A); - There are no recommendations for the use of piracetam, bromocriptine, galantamine, levodopa, or amphetamines (Recommendation III-A).

## Dysphagia
Dysphagia occurs in 65% to 90% of stroke patients and is associated with aspiration pneumonia, dehydration, malnutrition, and increased mortality. [bib_ref] Dysphagia and Associated Pneumonia in Stroke Patients from Brazil: A Systematic Review, Pacheco-Castilho [/bib_ref] Although spontaneous recovery from dysphagia occurs in stroke patients, 11% to 50% will have permanent dysphagia up to 6 months after the stroke, increasing the risk of pneumonia 3-fold. In poststroke patients with laryngotracheal aspiration, pneumonia is eight times higher. [bib_ref] Dysphagia and Associated Pneumonia in Stroke Patients from Brazil: A Systematic Review, Pacheco-Castilho [/bib_ref] Dysphagia screening should be performed early, and bedside evaluation can provide valuable information. [bib_ref] Dysphagia screening: state of the art: invitational conference proceeding from the Stateof-the-Art..., Donovan [/bib_ref] However, bedside evaluation alone cannot detect aspiration without clinical signs. [bib_ref] Dysphagia in stroke patients, Singh [/bib_ref] If silent aspirations are suspected, videofluoroscopy and fiberoptic endoscopic evaluations are appropriate methods to evaluate the swallowing mechanism. [bib_ref] Clinical Application of Flexible Endoscopic Evaluation of Swallowing in Stroke, Pisegna [/bib_ref] [bib_ref] Temporal and Sequential Analysis of the Pharyngeal Phase of Swallowing in Poststroke..., Saconato [/bib_ref] Rehabilitation of dysphagia in stroke patients is based on the concept of neuroplasticity; it involves compensatory strategies and modification of the physiology of swallowing. Compensatory strategies include volume and texture modifications and postural techniques such as a chin tuck position. [bib_ref] Swallowing therapy for dysphagia in acute and subacute stroke, Bath [/bib_ref] Some maneuvers may serve as a compensatory strategy and function as rehabilitative exercises, such as the effortful swallow, supraglottic swallow, super-supraglottic swallow, and the Mendelsohn maneuver. [bib_ref] Swallowing therapy for dysphagia in acute and subacute stroke, Bath [/bib_ref] Other exercises, such as the Shaker exercise and Masako maneuver, may improve swallowing physiology. Tactile, thermal, or sour taste stimulation and noninvasive neurostimulation therapies are also used. [bib_ref] Swallowing therapy for dysphagia in acute and subacute stroke, Bath [/bib_ref] Swallowing therapies in survivors up to six months after stroke may reduce the length of hospital stay, dysphagia, chest infections, and swallowing ability. [bib_ref] Swallowing therapy for dysphagia in acute and subacute stroke, Bath [/bib_ref] However, they do not significantly affect mortality, dependency/disability, and case fatality outcomes. [bib_ref] Swallowing therapy for dysphagia in acute and subacute stroke, Bath [/bib_ref] A randomized trial 29 demonstrated significant recovery from dysphagia, prevention of aspiration pneumonia, and reduced time to return to oral feeding in participants who initiated swallowing therapy in the first 48 hours and during the first 3 days compared with a delayed dysphagia program in rehabilitation.
Non-invasive neurostimulation therapies, such as rTMS, tDCS, and surface neuromuscular electrical stimulation pro-vide benefits regarding performance in heterogeneous swallowing tests. [bib_ref] The effects of surface neuromuscular electrical stimulation on poststroke dysphagia: a systemic..., Chen [/bib_ref] [bib_ref] Comparative Efficacy of Noninvasive Neurostimulation Therapies for Acute and Subacute Poststroke Dysphagia:..., Chiang [/bib_ref] However, the number and quality of the studies were relatively limited. Statistical heterogeneity was moderate, high, or not reported in some of the published meta-analyses 30,31 about the effects of these interventions in post-stroke dysphagia. Phase-3 clinical trials are required. There is no benefit with pharyngeal electrical stimuation. 32

## Recommendations
- Early swallowing therapies are recommended for recovery from dysphagia (Recommendation I-A); - Dysphagia screening should be performed early after stroke to prevent aspiration pneumonia, malnutrition, and dehydration (Recommendation I-B);

## Postural control and balance
Changes in balance and postural control are caused by motor impairment and loss of sensory and spatial orientation of the body. They are common after stroke and negatively affect the quality of life, activities, and participation of individuals. [bib_ref] Motor strategies of postural control after hemispheric stroke, Tasseel-Ponche [/bib_ref] Trunk training, with support, on unstable surfaces, such as balls used in physical therapy sessions, air mattresses, pillows, and boards, appears to be superior to stable surfaces to improve static and dynamic balances.There is strong evidence of the benefits of trunk control training in sitting as well as mobile and static balances. [bib_ref] The effectiveness of trunk training on trunk control, sitting and standing balance..., Van Criekinge [/bib_ref] Two systematic reviews with meta-analyses showed that virtual reality on its own 36 and virtual reality associated with conventional physiotherapy 37 effectively improved poststroke balance. Despite limited evidence, telerehabilitation, combined with virtual reality, for balance training, can be an alternative to overcome difficulty in accessing a rehabilitation service.Hydrotherapy significantly improved postural balance, more so in chronic patients than in patients in the subacute phase. [bib_ref] Effectiveness of Hydrotherapy on Balance and Paretic Knee Strength in Patients With..., Chae [/bib_ref] Aerobic exercise on a cycle ergometer has no positive effect on balance. 40, However, the effects of treadmill gait training, with or without weight support, have been found to be positive. [bib_ref] The efficacy of treadmill training on balance dysfunction in individuals with chronic..., Tally [/bib_ref] Peripheral somatosensory stimulation was beneficial in controlling postural stability in individuals in the poststroke chronic phase as an adjuvant therapy. [bib_ref] Peripheral somatosensory stimulation and postural recovery after stroke -a systematic review, Schroder [/bib_ref] A meta-analysis [bib_ref] Effects of robotic gait training after stroke: A meta-analysis, Moucheboeuf [/bib_ref] showed that robot-assisted gait training improved balance when compared with the absence of this intervention, despite the limitations of the analyzed studies.
The effects of mental imagery, rTMS, and tDCS are controversial due to the methodological variability in the studies. [bib_ref] Functional Balance and Postural Control Improvements in Patients With Stroke After Noninvasive..., Kang [/bib_ref] Functional task-training associated with musculoskeletal intervention and/or cardiopulmonary intervention and sensory interventions seem to be effective in improving balance and postural stability respectively. [bib_ref] Limited evidence of physical therapy on balance after stroke: A systematic review..., Hugues [/bib_ref] However, the heterogeneity of physical therapy and the weak methodological quality of studies limited the interpretation and the confidence in findings. [bib_ref] Limited evidence of physical therapy on balance after stroke: A systematic review..., Hugues [/bib_ref] The physical therapy techniques evaluated in this meta-analysis 47 included balance training, walking, transfers, getting up and down activities, reaching objects with upper limbs (ULs), active muscle strengthening, active-assisted and passive cardiopulmonary fitness, and sensory interventions such as thermal, tactile, visual, and vestibular stimulation.

## Ataxias
The term ataxia refers to a disturbance in voluntary movement present in cases of injury or damage to the cerebellum, cerebellar peduncle, and cerebellar pathways of the brainstem. [bib_ref] Response to intensive upper extremity therapy by individuals with ataxia from stroke, Richards [/bib_ref] Ataxia, present in 2% to 3% of patients after stroke, is a loss of coordination, dysmetria, dysarthria, hypotonia, rebound phenomenon, and nystagmus. [bib_ref] A Comparative Study of Conventional Physiotherapy versus Robot-Assisted Gait Training Associated to..., Belas Dos Santos [/bib_ref] There are few intervention studies on ataxia in stroke patients. Case studies indicate that task training with specific goals can improve limb ataxia in poststroke individuals, and rTMS is still in the experimental phase. 50

## Recommendations
- Task training, with specific goals, can be used in poststroke ataxia (Recommendation IIb-C); - Repetitive transcranial magnetic stimulation is still in the experimental phase and should not be routinely used in the treatment of post-stroke ataxia (Recommendation III-C).

## Spasticity
The prevalence of poststroke spasticity (PSS) ranges from 20% to 40%. [bib_ref] When does spasticity in the upper limb develop after a first stroke?..., Nam [/bib_ref] Loss of movement control, abnormal posture, increased muscle tone, painful spasms, and an overall decline in muscle function are the main symptoms. [bib_ref] When does spasticity in the upper limb develop after a first stroke?..., Nam [/bib_ref] Changes in the passive properties of muscles may lead to contractures. [bib_ref] When does spasticity in the upper limb develop after a first stroke?..., Nam [/bib_ref] The clinical assessment methods most commonly used include the Modified Ashworth Scale (MAS) and the Modified Tardieu Scale (MTS). [bib_ref] Their Clinical Relevance for Measuring Spasticity in Adult and Paediatric Neurological Populations, Ashworth [/bib_ref] A combination of rehabilitation techniques and pharmacological and non-pharmacological interventions produces better effects. [bib_ref] Botulinum Toxin Therapy Combined with Rehabilitation for Stroke: A Systematic Review of..., Hara [/bib_ref] Baclofen, tizanidine, and oral benzodiazepines, which are commonly used in daily practice, still lack good evidence for their use, with frequent adverse effects, especially in elderly patients. [bib_ref] Pharmacological interventions other than botulinum toxin for spasticity after stroke, Lindsay [/bib_ref] There is sufficient evidence to conclude that botulinum toxin is safe and effective in reducing UL and lower-limb spasticity after stroke. [bib_ref] Effectiveness of Botulinum Toxin Treatment for Upper Limb Spasticity Poststroke Over Different..., Andringa [/bib_ref] However, the effect on motor function remains unclear. [bib_ref] Botulinum Toxin Type A for the Treatment of Lower Limb Spasticity after..., Santamato [/bib_ref] A meta-analysis 57 showed improvement in impairment, but no significant effect on gait speed. A recent consensus of specialists 58 in the treatment of poststroke spasticity with botulinum toxin recommended an approach based on three key areas: individualized intervention, optimal injection technique and preparation of the toxin, and rehabilitation with adjuvant therapies concomitant with and after the injection of botulinum toxin.
Severe forms of PSS can be treated with intrathecal baclofen. [bib_ref] Effect of Intrathecal Baclofen on Pain and Quality of Life in Poststroke..., Creamer [/bib_ref] Among the non-pharmacological approaches, kinesiotherapy 60 and functional bandaging (taping) 61 can be considered. Splints and orthoses have uncertain benefits. [bib_ref] Hand splinting for poststroke spasticity: a randomized controlled trial, Basaran [/bib_ref] Transcutaneous electrical nerve stimulation (TENS) and functional electrical stimulation (FES) reduce spasticity in the lower limbs. [bib_ref] Effect of Transcutaneous Electrical Nerve Stimulation on Spasticity in Adults With Stroke:..., Mahmood [/bib_ref] [bib_ref] Functional electrical stimulation early after stroke improves lower limb motor function and..., You [/bib_ref] Acupuncture and electroacupuncture combined with conventional routine care may be beneficial for PSS. 65

## Recommendations
- The application of botulinum toxin to target muscles is recommended for the treatment of spasticity (Recommendation I-A); - Transcutaneous electrical nerve stimulation is recommended to reduce muscle spasticity in the lower limbs (Recommendation I-A); - Functional electrical stimulation of spastic muscles can be considered (Recommendation IIa-A); - Treatment with intrathecal baclofen can be used in refractory cases (Recommendation IIa-A); - Acupuncture, electroacupuncture, and functional bandaging should be considered (Recommendation IIa-A); - Kinesiotherapy may be considered in the treatment of spasticity (Recommendation IIb-B);
- Oral medications such as baclofen, tizanidine, and benzodiazepines may be used, always considering their adverse effects (Recommendation IIb-A); - The effects of botulinum toxin on function are uncertain (Recommendation IIb-A); - Splints and positioning orthoses have uncertain effects (Recommendation IIb-A).

## Upper limb
The UL is affected in 80% and 40% of patients in the acute and chronic phases after stroke respectively. 66 Impairments of the UL chronically limit functional independence and satisfaction in 50% to 70% of stroke patients. Weakness, hypotonia, hypertonia, joint instability, and loss of motor control cause functional limitations in reaching, grasping, and manipulating objects. [bib_ref] Rehabilitation of Motor Function after Stroke: A Multiple Systematic Review Focused on..., Hatem [/bib_ref] Although extensively used in rehabilitation, there is limited evidence favoring the Bobath approach. [bib_ref] Effectiveness of the Bobath concept in the treatment of stroke: a systematic..., Diaz-Arribas [/bib_ref] Strength training can improve UL strength and function without increasing tone or pain. [bib_ref] Strength training improves upper-limb function in individuals with stroke: a meta-analysis, Harris [/bib_ref] Resistance training is superior to other therapies for muscular strength and motor function. [bib_ref] Resistance training in stroke rehabilitation: systematic review and meta-analysis, Veldema [/bib_ref] There is no evidence that stretching therapy improves UL motor impairment and disability. [bib_ref] Rehabilitation of Motor Function after Stroke: A Multiple Systematic Review Focused on..., Hatem [/bib_ref] Although a previous meta-analysis suggested that constraint-induced movement therapy (CIMT) might be superior to traditional rehabilitation, the most recent Cochrane review 70 indicated that CIMT was associated with limited improvement in motor impairment and function, but these benefits did not reduce disability. However, another metaanalysis 71 showed significant benefits of CIMT in patients with acute or subacute stroke.
Biofeedback may have some beneficial impact, according to low-quality evidence. [bib_ref] Nature, timing, frequency and type of augmented feedback; does it influence motor..., Molier [/bib_ref] There is evidence of the effectiveness of mirror therapy in improving upper extremity motor function, motor impairment, activities of daily living, and pain, 73 in association with other conventional rehabilitation therapies for stroke patients. [bib_ref] Synergistic Effect of Combined Mirror Therapy on Upper Extremity in Patients With..., Luo [/bib_ref] Mental practice (MP) effectively reduces the limitations to UL activity after stroke, particularly in the first three months and in individuals with severe UL dysfunction. [bib_ref] Systematic Review and Meta-Analysis of the Effectiveness of Mental Practice for the..., Stockley [/bib_ref] Bilateral and unilateral UL training improved motor impairment and functional performance after stroke; however, bilateral training was superior in terms of improving motor impairment. [bib_ref] Comparison of bilateral and unilateral upper limb training in people with stroke:..., Chen [/bib_ref] Although some studies have shown positive effects with repetitive peripheral sensory stimulation (RPSS), [bib_ref] Repetitive Peripheral Sensory Stimulation and Upper Limb Performance in Stroke: A Systematic..., Conforto [/bib_ref] tDCS, [bib_ref] Different Therapeutic Effects of Transcranial Direct Current Stimulation on Upper and Lower..., Bai [/bib_ref] and rTMS, 79 these techniques are still under investigation.
When initiated within two months of the stroke, FES is a promising therapy for UL recovery. [bib_ref] Effectiveness of upper limb functional electrical stimulation after stroke for the improvement..., Eraifej [/bib_ref] However, the very low quality of the evidence analyzed means that a clear conclusion about its effects cannot be established. Robot-assisted therapy promotes the use of the affected limb, intensifies rehabilitation through task repetition, and offers task-specific practice. [bib_ref] Upper extremity rehabilitation using fully immersive virtual reality games with a head..., Lee [/bib_ref] Virtual reality (VR) provides augmented feedback and preserves motivation. [bib_ref] Effectiveness of Virtual Reality-and Gaming-Based Interventions for Upper Extremity Rehabilitation Poststroke: A..., Karamians [/bib_ref] A common denominator of VR systems and robot-assisted therapy is playful intervention by means of serious games. [bib_ref] Development of a robotic upper limb assessment to configure a serious game, Dehem [/bib_ref] A serious game is defined as a game that has education or rehabilitation as its primary goal. [bib_ref] Adaptation in serious games for upper-limb rehabilitation: an approach to improve training..., Hocine [/bib_ref] These games combine entertainment, attentional engagement, and problem solving to challenge function and performance. [bib_ref] Adaptation in serious games for upper-limb rehabilitation: an approach to improve training..., Hocine [/bib_ref] After a case of stroke, VR for the UL appears to be more effective than the conventional methods, [bib_ref] Virtual reality for stroke rehabilitation, Laver [/bib_ref] and it may be beneficial when used as an adjunct to usual care. Upper-limb rehabilitation through serious games showed more improvement when compared with the conventional treatment, and long-term effect retention was maintained for UL function, but heterogeneity was high. [bib_ref] Serious games for upper limb rehabilitation after stroke: a meta-analysis, Doumas [/bib_ref] Robot-assisted therapy might be superior to conventional rehabilitation in improving severe UL motor impairment in stroke patients with hemiplegia and limited potential for spontaneous recovery. [bib_ref] Robot-Assisted Therapy for Upper Extremity Motor Impairment After Stroke: A Systematic Review..., Wu [/bib_ref] There is insufficient evidence to support the efficacy of methylphenidate, trazodone, levodopa, and nortriptyline in UL recovery after stroke. [bib_ref] Rehabilitation of Motor Function after Stroke: A Multiple Systematic Review Focused on..., Hatem [/bib_ref] Fluoxetine for six months did not improve functional outcomes and increased the risk of bone fractures.Although not specific to UL, a recent guideline presented a weak recommendation for cerebrolysin (30 mL intravenously for at least ten days) and citalopram (20 mg) to promote early motor neurorehabilitation after acute ischemic stroke.

## Mobility
Limitations to mobility and activities related to gait are some of the most impacting sequelae of stroke. More than 20% of stroke survivors do not walk independently, and even if they achieve independence, most have difficulty ambulating in their communities. [bib_ref] Is accurate prediction of gait in nonambulatory stroke patients possible within 72..., Veerbeek [/bib_ref] An exercise program that combines cardiorespiratory training, to enhance cardiorespiratory fitness, and resistance training could promote greater walking speed, muscle strength, balance, and walking endurance. [bib_ref] Physical fitness training for stroke patients, Saunders [/bib_ref] Circuit class therapy (CCT) is superior to conventional therapy in improving mobility, independence, and gait speed in stroke patients. [bib_ref] Circuit class therapy for improving mobility after stroke, English [/bib_ref] The potential risk of falls should be considered. [bib_ref] Circuit class therapy for improving mobility after stroke, English [/bib_ref] Rhythmic auditory cueing enhances gait performance, dynamic postural stability, stride length, and cadence. [bib_ref] Effects of (music-based) rhythmic auditory cueing training on gait and posture post-stroke:..., Ghai [/bib_ref] Water-based exercises may improve muscle strength, balance, mobility, and aerobic capacity compared with land-based exercises.Improvement in the ability to walk independently with treadmill training (TT), with or without body weight support, was not superior when compared with no TT, but walking speed and walking endurance improved slightly in the short term. [bib_ref] Treadmill training and body weight support for walking after stroke, Mehrholz [/bib_ref] The effects were more significant, though not persistent, for those who were able to walk. [bib_ref] Treadmill training and body weight support for walking after stroke, Mehrholz [/bib_ref] Better recovery of walking speed and distance in ambulatory patients was observed with TT. [bib_ref] Treadmill walking improves walking speed and distance in ambulatory people after stroke..., Nascimento [/bib_ref] Gait in electromechanical-assisted training associated with physiotherapy after stroke promotes a greater chance of achieving independent walking than physiotherapy without these devices. [bib_ref] Electromechanical-assisted training for walking after stroke, Mehrholz [/bib_ref] Three months after stroke, participants who were not ambulatory seemed to benefit most from this type of intervention. [bib_ref] Electromechanical-Assisted Training for Walking After Stroke: A Major Update of the Evidence, Mehrholz [/bib_ref] Repetitive gait training within the first three months poststroke can lead to long-term functional improvements if provided with an end-effector robot. [bib_ref] Feasibility and effectiveness of repetitive gait training early after stroke: A systematic..., Schroder [/bib_ref] When compared with conventional therapy approaches, VR and interactive game training did not produce statistically significant changes in regarding improvements in gait speed or balance. [bib_ref] Virtual reality for stroke rehabilitation, Laver [/bib_ref] Compared with placebo or no intervention, there is no evidence of superiority in gait, motor function, and functional mobility after stroke from motor imagery. [bib_ref] Motor imagery for gait rehabilitation after stroke, Silva [/bib_ref] The Bobath approach was not superior in terms of regaining mobility, motor control of the lower limb and gait, balance, and activities of daily living of poststroke patients when compared with other interventions. [bib_ref] Effectiveness of the Bobath concept in the treatment of stroke: a systematic..., Diaz-Arribas [/bib_ref] No differences in motor function were observed between real acupuncture and sham acupuncture after stroke. [bib_ref] Acupuncture for stroke rehabilitation, Yang [/bib_ref] Stroke patients may require an assistive technology device to aid in mobility. These comprise orthoses, splints, wheelchairs, walkers, and crutches.
Ankle-foot orthosis (AFO) is recommended to position the ankle during gait to prevent foot drop injury and to improve gait kinetics and kinematics of both the knee and ankle joints in poststroke gait. [bib_ref] A systematic review and meta-analysis of the effect of an ankle-foot orthosis..., Tyson [/bib_ref] There are two AFO models: fixed AFOs are recommended for patients who demonstrate great ankle instability during gait, and articulated AFOs are indicated for patients with greater stability of the ankle joint. [bib_ref] Effect of ankle-foot orthosis on functional mobility and dynamic balance of patients..., De Paula [/bib_ref] [bib_ref] The effects of ankle-foot orthoses on walking speed in patients with stroke:..., Shahabi [/bib_ref] The AFO can improve ankle and knee kinematics, kinetics, and the energy cost of walking in stroke survivors. [bib_ref] Effect of ankle-foot orthosis on functional mobility and dynamic balance of patients..., De Paula [/bib_ref] However, no convincing evidence has been observed regarding walking speed. [bib_ref] The effects of ankle-foot orthoses on walking speed in patients with stroke:..., Shahabi [/bib_ref] A decrease in energy expenditure during gait with AFO was also observed. [bib_ref] Effect of types of ankle-foot orthoses on energy expenditure metrics during walking..., Daryabor [/bib_ref] Ankle joint stabilization improves with FES of the foot dorsiflexors. [bib_ref] A Clinical Practice Guideline for the Use of Ankle-Foot Orthoses and Functional..., Johnston [/bib_ref] It consists of a structure with different presentations in which plantar sensors are connected to superficial electrodes that promote the contraction of the tibial and dorsiflexor muscles, preventing foot drop during the swing phase of gait. 107 A meta-analysis 108 concluded that there was evidence that AFO and FES can increase gait speed, mobility, dynamic balance, quality of life, endurance, and muscle activation poststroke. Another meta-analysis 109 of low-quality evidence showed that FES applied to the paretic peroneal nerve, when combined with physiotherapy, can improve ankle dorsiflexion, balance, and functional mobility.
The benefits of walking with a cane poststroke are uncertain. A comparative study of the effect of a simple cane and a four-point cane in individuals three months after a stroke showed that the use of a cane improves gait symmetry, which is indicated for patients at the beginning of gait training. [bib_ref] Immediate effects of cane use on gait symmetry in individuals with subacute..., Beauchamp [/bib_ref] However, despite the methodological limitations of the studies, a systematic review 111 showed no improvement in gait parameters concerning speed, step length, cadence, and symmetry after stroke with a single support cane. There was a slight reduction in speed with a four-point cane compared with the gait without a mobility device. [bib_ref] Which type of cane is the most efficient, based on oxygen consumption..., Jeong [/bib_ref] Walkers can help gait in patients with balance deficits, but weakness in the UL or the inability to use the hand to grasp the walker is a limitation to their use. When comparing the use of a simple cane with a four-point cane and walkers, it was observed that the energy spent in gait in individuals who used a walker was higher.Mobility devices such as wheelchairs, walking sticks, and bath chairs are associated with greater independence after a stroke. 113

## Recommendations
- An exercise program, including cardiorespiratory and resistance training, should be used to improve gait after stroke (Recommendation I-A); - Circuit class training is recommended for walking and balance recovery poststroke (Recommendation I-A); - Functional electrical stimulation can be useful in improving ankle dorsiflexion, balance, and functional mobility (Recommendation IIa-B); - It is reasonable to use AFO in gait rehabilitation after stroke (Recommendation IIa-A); - Gait performance, dynamic postural stability, stride length, and cadence can be improved with rhythmic auditory cueing (Recommendation IIa-A); - Water-based exercises can be recommended for gait rehabilitation after stroke (Recommendation IIa-B);
- Treadmill training, with or without body weight support, can improve speed and walking endurance poststroke, and is reasonable to use (Recommendation IIa-B); - Electromechanical-assisted gait added to physiotherapy can be beneficial for gait recovery, mainly in the first three months poststroke, and for participants who are not able to walk.

## Cognition
Poststroke cognitive deficits occur early and are quite frequent, as they appear within the first 3 months in up to 55% of patients when at least 1 cognitive domain is considered. [bib_ref] Dementia and cognitive impairment three months after stroke, Madureira [/bib_ref] Poststroke dementia occurs when there is cognitive decline immediately after or within the first six months after vascular ictus, with no evidence of improvement in this period. [bib_ref] The Vascular Impairment of Cognition Classification Consensus Study. Alzheimers Dement, Skrobot [/bib_ref] Since an informal clinical evaluation may underdiagnose cognitive decline, the use of test that have already been validated is recommended. [bib_ref] National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment..., Hachinski [/bib_ref] No superiority was observed among the tests that assess cognition. [bib_ref] Test accuracy of cognitive screening tests for diagnosis of dementia and multidomain..., Lees [/bib_ref] Reducing the levels of systolic blood pressure is effective in decreasing the incidence of poststroke cognitive deficit. [bib_ref] Thijs LSystolic Hypertension in Europe Trial Investigators. Risk and benefit of treatment..., Celis [/bib_ref] The use of statins shows conflicting results.Donepezil and galantamine may be useful to improve poststroke cognition, but the benefits of memantine and rivastigmine are not well established.Evidence 121 suggests that physical activity is an intervention with a protective role that may improve poststroke cognition. In addition, it is a low-cost strategy with a positive impact on motor function, quality of life, and cardiopulmonary condition.Cognitive rehabilitation has shown benefits, improving poststroke memory and attention, but with limited conclusions regarding its efficacy due to the quality of the studies published. [bib_ref] CMTask Force on Cognitive Rehabilitation European Federation of Neurological Societies. EFNS guidelines..., Cappa [/bib_ref] The association between cognitive and physical rehabilitation seems to provide greater benefits than isolated therapies. [bib_ref] Effects of combined intervention of physical exercise and cognitive training on cognitive..., Bo [/bib_ref] Studies 125 with VR are isolated, but show promising results. A meta-analysis 126 of four systematic reviews on poststroke cognitive impairments showed that acupuncture is safe and improves cognitive function without serious adverse events in stroke patients.
Repetitive transcranial magnetic stimulation and tDCS are still in an exploratory stage. [bib_ref] The Effect of Non-Invasive Brain Stimulation (NIBS) on Attention and Memory Function..., Hara [/bib_ref] There is no evidence to

## Unilateral spatial neglect
The non-recognition of space, usually on one side of the body, or of any stimulus applied to it, is called hemineglect syndrome or unilateral spatial neglect (USN), [bib_ref] Definition: Spatial neglect, Cubelli [/bib_ref] and it designates a consistent, exaggerated spatial asymmetry in processing information in bodily and/or extrabodily space due to an acquired cerebral lesion, which cannot be explained by primary motor or sensory deficits. The processing of neglected information can occur implicitly, without reaching consciousness, and can influence task performance. [bib_ref] Definition: Spatial neglect, Cubelli [/bib_ref] Unilateral space neglect occurs in $ 50% of individuals after right-hemisphere stroke, and it may persist in 75%, with some symptoms, in the chronic phase. [bib_ref] Hemispatial neglect, Parton [/bib_ref] Patients with neglect are often unaware of or fail to acknowledge items on their contralesional side and attend instead to items on the same side as their brain damage-their ipsilesional side. [bib_ref] Hemispatial neglect, Parton [/bib_ref] Unilateral space neglect causes prolonged hospitalization, impaired functional recovery, and reduced quality of life. [bib_ref] Unilateral spatial neglect in the acute phase of ischemic stroke can predict..., Luvizutto [/bib_ref] Several rehabilitation methods have been developed to improve spatial neglect in the last few decades. These can be classified according to their theoretical basis: 132 1) enhancing awareness of neglect behavior through a top-down mechanism; 2) low-level bottom-up sensory stimulation; and 3) neuromodulation.
Top-down treatments consist of training the gaze direction using cues from the patient's left side. Videos to show the patient their omissions during recorded functional tasks and mental images can also be used. However, these methods are limited because they require attention skills, which can be hampered by the lack of awareness of spatial neglect behaviors, such as anosognosia. [bib_ref] Top-down and bottom-up approaches for the treatment of unilateral spatial neglect in..., Dinten-Fernandez [/bib_ref] Bottom-up treatments, including prismatic adaptation, visual scanning training, optokinetic stimulation, VR, limb activation, neck vibration combined with prism adaptation, voluntary trunk rotation, and vestibular rehabilitation improve immediate and long-term performance in USN. [bib_ref] Top-down and bottom-up approaches for the treatment of unilateral spatial neglect in..., Dinten-Fernandez [/bib_ref] [bib_ref] Virtual reality treatment and assessments for post-stroke unilateral spatial neglect: A systematic..., Ogourtsova [/bib_ref] Moderate-quality evidence showed that rTMS was more efficient than sham for USN after stroke. [bib_ref] Noninvasive Brain Stimulations for Unilateral Spatial Neglect after Stroke: A Systematic Review..., Kashiwagi [/bib_ref] Repetitive transcranial magnetic stimulation in the posterior parietal cortex, and theta-burst stimulation, improved USN after stroke. [bib_ref] The effect of theta-burst stimulation on unilateral spatial neglect following stroke: a..., Cotoi [/bib_ref] Very low-quality evidence suggested that tDCS has a beneficial effect in improving USN after stroke. 136

## Recommendations
- Repeated "top-down" and "bottom-up" interventions can be considered, such as prismatic adaptation, visual scanning training, optokinetic stimulation, VR, limb activation, motor imagery, voluntary trunk rotation, vestibular rehabilitation, and vibration of the neck combined with prismatic adaptation to improve USN after stroke (Recommendation IIa-A); - The benefits of tDCS and rTMS to reduce USN after stroke are uncertain (Recommendation IIb-A).

## Sensory impairment (hearing, vision, and touch)
Sensory impairment after stroke, including hearing, vision, touch, and proprioception, is directly linked to activity limitations and participation restrictions. [bib_ref] Sensory loss in hospital-admitted people with stroke: characteristics, associated factors, and relationship..., Tyson [/bib_ref] However, they can improve with therapeutic intervention, particularly multimodal interventions. [bib_ref] A review of the evidence underpinning the use of visual and auditory..., Parker [/bib_ref] Hearing loss of a vascular cause is usually associated with cerebellar infarction in the territory of the anterior inferior cerebellar artery. [bib_ref] Recent Advances in Cerebellar Ischemic Stroke Syndromes Causing Vertigo and Hearing Loss, Kim [/bib_ref] The incidence of hearing loss in stroke patients is twice as high as that of non-stroke individuals, and it can limit participation in rehabilitation programs. [bib_ref] Risk of sudden sensorineural hearing loss in stroke patients: A 5-year nationwide..., Kuo [/bib_ref] Approximately 20% of stroke survivors report severe difficulties with speech recognition in the presence of background noise, despite normal audiometry.Hearing loss is usually treated with a personal frequency-modulated (FM) system with meaningful benefits. 142 A prospective, nonrandomized, controlled study in stroke patients showed clinical improvements in the speech reception threshold with the use of a personal FM system. [bib_ref] Long-term use benefits of personal frequency-modulated systems for speech in noise perception..., Koohi [/bib_ref] Visual impairment after stroke has a prevalence of 73% in the acute stroke population. [bib_ref] High incidence and prevalence of visual problems after acute stroke: An epidemiology..., Rowe [/bib_ref] The four most impaired visual functions are reduced central vision, loss of the peripheral visual field, eye movement disorders, and visual perception disorders. [bib_ref] Vision In Stroke cohort: Profile overview of visual impairment, Group [/bib_ref] For the treatment of visual loss, prism lenses, unilateral eye occlusion, adapted lighting, picture amplification, environment modification, orthoptic exercises, Fresnel prism, verbal, written, and head posture advice have been employed. [bib_ref] Interventions for visual field defects in people with stroke, Pollock [/bib_ref] The evidence for all these interventions is weak, and there is a lack of evidence relating to their effect on functional ability in activities of daily living. [bib_ref] Interventions for visual field defects in people with stroke, Pollock [/bib_ref] One in two individuals who had a stroke had reduced sensation, impacting both the ability to function independently and the overall quality of life. [bib_ref] Effects of Somatosensory Impairment on Participation After Stroke, Carey [/bib_ref] In acute ischemic stroke, almost 60% of patients showed somatosensory impairment in at least one subitem in the acute stage, but there is considerable recovery over time. Reduced sensation is associated with reduced motor function in terms of quality of movement control, and lesser rehabilitation outcomes. [bib_ref] Somatosensory Deficits After Ischemic Stroke, Kessner [/bib_ref] Sensory rehabilitation, which triggers the activation of the cutaneous nerves, can be performed with somatosensory afferents, such as thermal, pressure, peripheral nerve, transcutaneous electrical nerve, and vibration stimulations. [bib_ref] A sensorimotor stimulation program for rehabilitation of chronic stroke patients, De Diego [/bib_ref] Additionally, a sensory retraining approach based on graded re-education using learning principles and augmenting sensory input, such as proprioception, tactile recognition, desensitization, stereognosis, location, and discrimination is another option for sensory stimulation. Additionally, with haptic-based augmented reality, feedback devices that augment targeted sensory afferents can be used. [bib_ref] A sensorimotor stimulation program for rehabilitation of chronic stroke patients, De Diego [/bib_ref] Systematic reviews and meta-analyses have shown that a varied range of intervention methods intended for retraining leg somatosensory function after stroke effectively improves somatosensory impairment and balance, but not gait. [bib_ref] Sensory retraining of the leg after stroke: systematic review and meta-analysis, Chia [/bib_ref] A systematic review showed that somatosensory retraining may assist people in regaining somatosensory discrimination skills in the arm after stroke. 151

## Recommendations
- Frequency-modulated systems are recommended for hearing loss after stroke (Recommendation I-B); - Leg somatosensory retraining can be used to improve balance after stroke (Recommendation IIa-A); - Arm somatosensory retraining can improve somatosensory discrimination skills after stroke (Recommendation IIa-A); - Prism lenses, unilateral eye occlusion, adapted lighting, picture amplification, environment modification, orthoptic exercises, Fresnel prism, verbal, written, and head posture advice may be used for visual impairment after stroke (Recommendation IIb-C).

## Rehabilitation continuity: home rehabilitation, return to leisure, work, and driving
Home rehabilitation (HR) should be part of the ongoing rehabilitation planning, according to a meta-analysis. [bib_ref] Systematic Review and Meta-Analysis of Home-Based Rehabilitation on Improving Physical Function Among..., Chi [/bib_ref] Well-established and early HR resulted in a better quality of life. [bib_ref] Systematic Review and Meta-Analysis of Home-Based Rehabilitation on Improving Physical Function Among..., Chi [/bib_ref] Resistive reach and grip exercises in the home environment showed positive results in the activity level of the ULs. [bib_ref] Effects of functional and analytical strength training on upper-extremity activity after stroke:..., Graef [/bib_ref] Home mirror therapy associated with repetition training and activities of daily living can result in better responses in motor activity and in the sit-and-stand test. [bib_ref] Effects of Home-Based Versus Clinic-Based Rehabilitation Combining Mirror Therapy and Task-Specific Training..., Hsieh [/bib_ref] Visuomotor feedback training at home was an effective method to improve USN. [bib_ref] Efficacy of home-based visuomotor feedback training in stroke patients with chronic hemispatial..., Rossit [/bib_ref] In poststroke home treatment, VR was beneficial for UL mobility. [bib_ref] Home-based Upper Extremity Stroke Therapy Using a Multiuser Virtual Reality Environment: A..., Thielbar [/bib_ref] Home rehabilitation with glove therapy and fingertip sensors with visual feedback on a screen according to the movements performed improved hand movement compared with conventional treatment in HR. [bib_ref] Home-based hand rehabilitation after chronic stroke: Randomized, controlled single-blind trial comparing the..., Zondervan [/bib_ref] Home caregivers promoted positive results for poststroke physical function and depressive symptoms.Stroke patients have been shown to have difficulties participating in leisure and recreational activities. [bib_ref] Systematic Review and Meta-Analysis of Home-Based Rehabilitation on Improving Physical Function Among..., Chi [/bib_ref] Recreational activity programs improved physical and mental function. [bib_ref] Predictors of return to work after stroke: a prospective, observational cohort study..., Nascimento [/bib_ref] Less than 50% of poststroke patients can return to work 6 months post-stroke and 50% have deficiencies in performing work activities 5 years after the event. [bib_ref] The effect of a workplace intervention programme on return to work after..., Ntsiea [/bib_ref] Intervention in the work environment promoted a higher percentage of return to work. [bib_ref] The effect of a workplace intervention programme on return to work after..., Ntsiea [/bib_ref] Occupational rehabilitation interventions have shown positive effects on accommodation to the environment and job satisfaction. [bib_ref] The ReWork-Stroke rehabilitation programme described by use of the TIDieR checklist, Johansson [/bib_ref] After a stroke, drivers may have compromised reflexes, leading to risks behind the wheel, with a consequent increase in the chances of collisions, excessive speed, and invasion of the opposite lane. [bib_ref] Rehabilitation for improving automobile driving after stroke, George [/bib_ref] Although the effects of rehabilitation on poststroke return to steering are uncertain, the use of a rotary knob in steering in a specific position and driving simulators can be used as tools for a return to driving activity after stroke. [bib_ref] Muscle activation of drivers with hemiplegia caused by stroke while driving using..., Jung [/bib_ref] 

## Recommendations

## Medication adherence
Medication adherence is defined as "the extent to which a person's behavior when using medications corresponds with the agreed recommendations from a health care provider".Five dimensions and two factors influence adherence behavior. The five dimensions are the patient, the health system, socioeconomic status, therapy, and health status.
The factors are classified as intentional, such as skipping a dose of the drug when considering that the symptoms are under control, and unintentional, such as skipping a dose due to forgetfulness.Limitations to the adherence to medications affect $ 50% of poststroke individuals.Patients with atrial fibrillation and greater adherence to oral anticoagulants have a lower risk of stroke, transient ischemic attack, and mortality.Better adherence to statins and antihypertensives is also associated with a lower risk of stroke. [bib_ref] Adherence to Antihypertensive Medications and Stroke Risk: A Dose-Response Meta-Analysis, Xu [/bib_ref] On the other hand, non-adherence is associated with a greater chance of recurrence, mortality, long-term disability, and dementia. [bib_ref] Long-term mortality after first-ever and recurrent stroke in young adults, Aarnio [/bib_ref] Better medication adherence is associated with better knowledge of medications and the need to use them. [bib_ref] Mobile phone text messaging to improve medication adherence in secondary prevention of..., Adler [/bib_ref] Although promising, the use of automated telecommunication interventions, including text messages and interactive voice response, showed conflicting results in two metaanalyses 168,169 that analyzed medication adherence for secondary prevention of cardiovascular disease. Intervention with telephone support, conducted mainly by nurses, can be effective. [bib_ref] Telemedical strategies for the improvement of secondary prevention in patients with cerebrovascular..., Kraft [/bib_ref] Medication adherence improved after self-management interventions to better control risk factors in poststroke individuals. [bib_ref] A Systematic Review of Randomized Controlled Trials of Medication Adherence Interventions in..., Wessol [/bib_ref] Interventions based on cognitive and behavioral orientation, such as simplifying the act of taking medications, environment reminders, and information to improve drug treatment beliefs, improved medication adherence after stroke. 170

## Recommendations
- Interventions based on cognitive and behavioral orientation should be conducted to improve medication adherence (Recommendation I-A);

## Palliative care
Neurological palliative care (PC) has become increasingly important and relevant in studies worldwide. Considering that it is comprehensive, multidisciplinary care, it makes perfect sense to apply it to patients with neurological diseases, especially those affected by stroke, to alleviate and prevent the suffering of people with serious, life-threatening diseases.Palliative care should be initiated early in stroke patients, not only when the patient is close to death. [bib_ref] American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, and..., Holloway [/bib_ref] neurology or Intensive Care Unit (ICU) team and by a PC service at the time of diagnosis. [bib_ref] Neuropalliative care: Priorities to move the field forward, Creutzfeldt [/bib_ref] There are three possible models for the integration of neurological care and PC. [bib_ref] Neuropalliative care: Priorities to move the field forward, Creutzfeldt [/bib_ref] The first one is the consultative model, through an exceptional evaluation via consultation with the PC team. The second one is the integrated model, in which the teams work together simultaneously. The third one is primary neuropalliative care, in which the neurologist is trained to provide primary PC and determine when there is a need for referral to a specialized team.
In the last model, neurological PC provides greater involvement, as the neurologist who follows the patient since the diagnosis has a stronger connection and more data to predict and define a therapeutic plan. [bib_ref] Neuropalliative care: Priorities to move the field forward, Creutzfeldt [/bib_ref] The main contributions of the neurologist in primary PC, which can be useful for every professional involved in the care of the patient, are recognizing the PC needs associated with each neurological disease, identifying and treating pain, providing basic psychosocial and spiritual support, acquiring communication skills (including empathic listening), evaluating the prognosis, supporting patients and families regarding tragic choices, being aware of last-resort PC options, and acknowledging and managing the caregiver's distress and needs. [bib_ref] American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, and..., Holloway [/bib_ref] Neurologists should also know how to identify an indication for specialized (or secondary) PC, which includes management of refractory and complex physical symptoms, management of complex psychological and spiritual suffering, assistance in conflict resolution in relation to the objective and treatment options, transfer to hospice, and end-oflife management. 173

## Recommendations
- Palliative care is recommended for people with stroke in cases of reduced quality of life and reduced life expectancy (Recommendation I-C); - Palliative care should be provided by neurologists, the ICU team, and the PC Service at the time of diagnosis (Recommendation I-B); - Formal assessment of PC should be recommended in endof-life situations, in the presence of refractory pain, dyspnea, agitation, mood disorders, long-term feeding assistance, ventilation, palliative extubation, and assistance in resolving conflicts between family members and health teams (Recommendation I-B).

## Cerebrovascular events related to sars-cov-2 infection
Infection by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) has been heavily associated with short-and medium-term neurological complications. [bib_ref] Neurological symptoms, manifestations, and complications associated with severe acute respiratory syndrome coronavirus..., Harapan [/bib_ref] These conditions increase the risk of headache, encephalopathy, epileptic seizures, delirium, and cerebrovascular events such as ischemia, intracranial hemorrhage, central venous thrombosis, and subarachnoid hemorrhage. [bib_ref] Neurological symptoms, manifestations, and complications associated with severe acute respiratory syndrome coronavirus..., Harapan [/bib_ref] The incidence of cerebrovascular disease in patients with active SARS-Cov-2 infection ranges from 2.3% to 6%, and it is higher among patients with more severe infection. [bib_ref] Neurological symptoms, manifestations, and complications associated with severe acute respiratory syndrome coronavirus..., Harapan [/bib_ref] One study 174 reported that central venous thrombosis occurred in 0.3% of cases, and infection increased the frequency of involvement of multiple cerebral arterial territories, with more extensive lesions and subsequent greater neurological severity. At the same time, younger people were more affected than controls. [bib_ref] Neurological symptoms, manifestations, and complications associated with severe acute respiratory syndrome coronavirus..., Harapan [/bib_ref] The coronavirus disease 2019 (COVID-19) pandemic has radically changed processes, patient access, and stroke care. However, the nature and quality of stroke care across the entire service line have proven benefits in long-term results. [bib_ref] Canadian Stroke Best Practices Advisory Council. Canadian Stroke Best Practice Guidance During..., Smith [/bib_ref] Standards and scope in the care of stroke patients must be maintained; otherwise, the recurrence rate of stroke and ongoing disabilities in general will increase and generate a new burden on an already overloaded service network. Overall, measures to preserve the best stroke management practices must be implemented in the context of the pandemic across the health system. Alternative care models such as telerehabilitation may provide greater access to care for stroke patients during the COVID-19 pandemic. [bib_ref] Canadian Stroke Best Practices Advisory Council. Canadian Stroke Best Practice Guidance During..., Smith [/bib_ref] However, the literature is still scarce, and robust evidence on stroke rehabilitation related to SARS-CoV-2 infection is lacking.

## Recommendations
- Rehabilitation strategies must comprise a multidisciplinary approach focusing on neurological impairments and disabilities after stroke that is related to SARS-CoV-2 infection (Recommendation IIb-C); - Access to specialized centers such as stroke units, outpatient care, early support on discharge, and community stroke rehabilitation might be considered for stroke related to SARS-CoV-2 (Recommendation IIb-C).

## Future of stroke rehabilitation
The flourishing of rehabilitation science has broadened knowledge about the heterogeneity of plasticity and recovery mechanisms in different individuals and poststroke phases. [bib_ref] Plasticity during stroke recovery: from synapse to behaviour, Murphy [/bib_ref] To develop clinically-relevant strategies, solid bridges need to be built between studies in animals, proofof-concept studies, randomized clinical trials in different phases, pragmatic studies, good-quality meta-analyses, and the practical needs of the patients, their families, professionals, and health services. In recent years, studies such as EXCITE, FLAME, FOCUS, and AVERT (for a review, please check the study by Cramer 177 ), among others, have shown that it is possible to test rehabilitation interventions and understand that patient characteristics are crucial for choosing therapies with a greater likelihood of success. "Precision rehabilitation" with realistic and individualized goals can thus be implemented.
With this approach, it becomes crucial to define "the right therapy for the right patient at the right time". Consensus on outcomes to be used in rehabilitation research, advances in neurophysiology techniques, structural and functional neuroimaging, genetics, data science, and artificial intelligence (AI), recognition of the importance of interdisciplinary work, patient opinions or preferences regarding the goals of the rehabilitation process, as well as the involvement of patients in this process, have contributed to increasing innovations. [bib_ref] Impact of Telerehabilitation for Stroke-Related Deficits, Knepley [/bib_ref] [bib_ref] National Institutes of Health StrokeNet Telerehab Investigators. Efficacy of Home-Based Telerehabilitation vs..., Cramer [/bib_ref] Among the techniques that may be included in poststroke rehabilitation in the future, for example, through the enhancement of adaptive mechanisms of plasticity, are the use of drugs, non-invasive brain-computer interface (NIBCI), and behavioral interventions. [bib_ref] A clinical evaluation on the spatial patterns of non-invasive motor imagery-based brain-computer..., Ang [/bib_ref] Social isolation during the COVID-19 pandemic underscored the need to develop telerehabilitation tools that use strategies such as videoconferencing to supervise rehabilitation activities. A study 179 compared this intervention with the same rehabilitation protocol applied in an out-ofhome environment and observed an improvement in the levels of disability, balance, and stress of the caregiver without distinctions among groups. Telerehabilitation may be effective for motor rehabilitation and is less costly than conventional therapy. [bib_ref] Impact of Telerehabilitation for Stroke-Related Deficits, Knepley [/bib_ref] Technological advances may increase the effectiveness of different telerehabilitation techniques and leverage other promising perspectives such as NIBCI, 180 wearable sensors, 181 devices for communication in critically-ill patients, 182 feedback and motivation systems, [bib_ref] Effect of a mixed realitybased intervention on arm, hand, and finger function..., Colomer [/bib_ref] and interactive robots, 184 among others. Despite many exciting possibilities, there is still a gap between research and the daily practice. For the design, testing, and implementation of useful strategies in the practice, it is essential that networks bring together researchers and rehabilitation professionals so that multicenter studies can be performed by considering the needs and opportunities in local, regional, or national cost-effectiveness contexts. Interventions that work in other countries may not work well in Brazil, and vice versa. Facilitators and barriers to rehabilitation can be very different in a large urban center and a small town in the heart of the Amazon. Access to rehabilitation after stroke in different Brazilian regions has been evaluated by the Access to Rehabilitation after Stroke (AReA) study.Therapies based on new technologies do not always result in clinical benefits and are sometimes accompanied by costs that make them unaffordable for many. Therefore, it is crucial to choose evidence-based rehabilitation interventions suited for our reality. By doing so, we will be able to drastically impact the quality of life of millions of people with stroke.

## Suggested sites for patients and caregivers

# Conclusions
The field of rehabilitation is open to incorporating new interventions to enhance the practice and the care after stroke. There have been significant breakthroughs in the last two decades through randomized controlled trials on stroke rehabilitation. High-level evidence supports the following recommendations: early speech, language, and swallowing therapy; specific training exercises for balance; botulinum toxin to reduce spasticity; mirror therapy; mental practice; unilateral and bilateral training; strengthening of upper limb improvement; cardiorespiratory and resistance training for gait recovery; physical activity as an adjunctive treatment to cognitive decline; and home planned rehabilitation after stroke. Future research is needed to establish the role of new technologies, such as neuromodulation, robotics, VR, and telerehabilitation as a routine in the clinical practice.

# Authors' contributions
[fig] : Surface neuromuscular electrical stimulation, rTMS, and tDCS are under investigation, but evidence about their clinical effectiveness is not well established (Recommendation IIb-A); Videofluoroscopy and fiberoptic endoscopic evaluations can be performed if aspiration is suspected without clinical symptoms or signs (Recommendation IIa-B); Pharyngeal electrical stimulation is not recommended to improve dysphagia after stroke (Recommendation III-A). [/fig]
[table] - 46: Arquivos de Neuro-Psiquiatria Vol. 80 No. 7/2022  2022. Academia Brasileira de Neurologia. All rights reserved. [/table]