Immunoglobulin like domain cd05751
The United States National Library of Medicine (NLM) is a biomedical library in the United States as part of the National Institutes of Health that contains "hierarchical classifications of widely distributed protein domain families  conserved sites associated with molecular function, so that they can be mapped onto user queries in support of hypothesis-driven biomolecular research."
"At the time of writing, the CDD version v3.17 is the live production version with 52,910 protein- and protein domain-models obtained from Pfam (1), SMART (2), the COGs collection (3), TIGRFAMS (4), the NCBI Protein Clusters collection (5), NCBIfam (6) and CDDs in-house data curation effort (7)."

# Immunoglobulin supergene family
The immunoglobulin supergene family is "the group of proteins that have immunoglobulin-like domains, including histocompatibility antigens, the T-cell antigen receptor, poly-IgR, and other proteins involved in the vertebrate immune response (17)."

# Alpha-1-B glycoprotein variants
Gene ID: 1 A1BG alpha-1-B glycoprotein on 19q13.43: "The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins."
"1B-glycoprotein(1B)  consists of a single polypeptide chain N-linked to four
glucosamine oligosaccharides. The polypeptide has five intrachain disulfide bonds and contains 474 amino acid residues.  1B exhibits internal duplication and consists of five repeating structural domains, each containing about 95 amino acids and one disulfide bond.  several domains of 1B, especially the third, show statistically significant homology to variable regions of certain immunoglobulin light and heavy chains. 1B  exhibits sequence similarity to other members of the immunoglobulin supergene family such as the receptor for transepithelial transport of IgA and IgM and the secretory component of human IgA."
"Some of the domains of 1B show significant homology to variable (V) and constant (C) regions of certain immunoglobulins. Likewise, there is statistically significant homology between 1B and the secretory component (SC) of human IgA (15) and also with the extracellular portion of the rabbit receptor for transepithelial transport of polymeric immunoglobulins (IgA and IgM). Mostov et al. (16) have called the later protein the poly-Ig receptor or poly-IgR and have shown that it is the precursor of SC."
"1B-glycoprotein(1B)  consists of a single polypeptide chain N-linked to four
glucosamine oligosaccharides. The polypeptide has five intrachain disulfide bonds and contains 474 amino acid residues.  1B exhibits internal duplication and consists of five repeating structural domains, each containing about 95 amino acids and one disulfide bond.  several domains of 1B, especially the third, show statistically significant homology to variable regions of certain immunoglobulin light and heavy chains. 1B  exhibits sequence similarity to other members of the immunoglobulin supergene family such as the receptor for transepithelial transport of IgA and IgM and the secretory component of human IgA."
A1BG contains the immunoglobulin domain: cl11960 and three immunoglobulin-like domains: pfam13895, cd05751 and smart00410 in the order and nucleotide sequence: cd05751 Location: 401  493, smart00410 Location: 218  280, pfam13895 Location: 210  301 and cl11960 Location: 28  110.

# cd05751
"Ig1_LILR_KIR_like:  domain similar to the first immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs) and Natural killer inhibitory receptors (KIRs). This group includes LILRB1 (or LIR-1), LILRA5 (or LIR9), an activating natural cytotoxicity receptor NKp46, the immune-type receptor glycoprotein VI (GPVI), and the IgA-specific receptor Fc-alphaRI (or CD89). LILRs are a family of immunoreceptors expressed on T and B cells, on monocytes, dendritic cells, and subgroups of natural killer (NK) cells. The human LILR family contains nine proteins (LILRA1-3,and 5, and LILRB1-5). From functional assays, and as the cytoplasmic domains of various LILRs, for example LILRB1 (LIR-1), LILRB2 (LIR-2), and LILRB3 (LIR-3) contain immunoreceptor tyrosine-based inhibitory motifs (ITIMs) it is thought that LIR proteins are inhibitory receptors. Of the eight LIR family proteins, only LIR-1 (LILRB1), and LIR-2 (LILRB2), show detectable binding to class I MHC molecules; ligands for the other members have yet to be determined. The extracellular portions of the different LIR proteins contain different numbers of Ig-like domains for example, four in the case of LILRB1 (LIR-1), and LILRB2 (LIR-2), and two in the case of LILRB4 (LIR-5). The activating natural cytotoxicity receptor NKp46 is expressed in natural killer cells, and is organized as an extracellular portion having two Ig-like extracellular domains, a transmembrane domain, and a small cytoplasmic portion. GPVI, which also contains two Ig-like domains, participates in the processes of collagen-mediated platelet activation and arterial thrombus formation. Fc-alphaRI is expressed on monocytes, eosinophils, neutrophils and macrophages; it mediates IgA-induced immune effector responses such as phagocytosis, antibody-dependent cell-mediated cytotoxicity and respiratory burst."

# Carcinoembryonic antigen gene family

# Immunoglobulin superfamily genes

# Major histocompatibility complex genes

## Class I

## Class II

## Class III

## Immunoglobulin domain genes

## Immunoglobulin receptor superfamily

# Genes having immunoglobulin like domain cd05751
Number of genes = 14.
Gene ID: 1 see Immunoglobulin domain genes.
Gene ID: 2204 is FCAR Fc fragment of IgA receptor on 19q13.42: "This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene."
- NP_001991.1 immunoglobulin alpha Fc receptor isoform a precursor: "Transcript Variant: This variant (1, also known as a.1) represents the longest transcript and encodes the longest isoform (a)." Conserved Domains (2) summary: cd05711 Location: 125  215 Ig2_LILR_KIR_like; Second immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, natural and similar domains, cd05751 Location: 27  120 Ig1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains.
- NP_579803.1 immunoglobulin alpha Fc receptor isoform b precursor: "Transcript Variant: This variant (2, also known as a.2, delta66EC2, or U06) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a." Conserved Domains (1) summary: cl11960 Location: 125  197 Ig; Immunoglobulin domain.
- NP_579805.1 immunoglobulin alpha Fc receptor isoform c precursor: "Transcript Variant: This variant (3, also known as a.3, Rla2, deltaE2, or U08) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a." Conserved Domains (1) summary: cl11960 Location: 27  120 Ig; Immunoglobulin domain.
- NP_579806.1 immunoglobulin alpha Fc receptor isoform d: "Transcript Variant: This variant (4, also known as deltaS2 or U11) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a." Conserved Domains (2) summary: cd05711 Location: 113  203 Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI and cl11960 Location: 15  108 Ig; Immunoglobulin domain.
- NP_579807.1 immunoglobulin alpha Fc receptor isoform e:"Transcript Variant: This variant (5, also known as U10) lacks alternate in-frame exons in the 5' and 3' coding region, compared to variant 1. The encoded isoform (e) is shorter than isoform a." Conserved Domains (1) summary: cl11960 Location: 15  108 Ig; Immunoglobulin domain.
- NP_579808.1 immunoglobulin alpha Fc receptor isoform f: "Transcript Variant: This variant (6, also known as U09) lacks an in-frame exon in the 5' coding region and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (f) has a distinct C-terminus and is shorter than isoform a." Conserved Domains (1) summary: cl11960 Location: 113  180 Ig; Immunoglobulin domain.
- NP_579811.1 immunoglobulin alpha Fc receptor isoform g: "Transcript Variant: This variant (7, also known as deltaS2ECl or L10) lacks two in-frame exons in the 5' coding region, compared to variant 1. The encoded isoform (g) is shorter than isoform a." Conserved Domains (1) summary: cd05711 Location: 16  106 Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI.
- NP_579812.1 immunoglobulin alpha Fc receptor isoform h: "Transcript Variant: This variant (8, also known as deltaS266Ec2 or U13) lacks an in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (h) is shorter than isoform a." Conserved Domains (1) summary: cl11960 Location: 113  185 Ig; Immunoglobulin domain.
- XP_011524927.1 immunoglobulin alpha Fc receptor isoform X1 Conserved Domains (2) summary: cd05711 Location: 98  188 Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI and cl11960 Location: 2  93 Ig; Immunoglobulin domain.
- XP_016881962.1 immunoglobulin alpha Fc receptor isoform X1 Conserved Domains (2) summary: cd05711 Location: 98  188 Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI and cl11960 Location: 2  93 Ig; Immunoglobulin domain.
- XP_016881963.1 immunoglobulin alpha Fc receptor isoform X1 Conserved Domains (2) summary: cd05711 Location: 98  188 Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI and cl11960 Location: 2  93 Ig; Immunoglobulin domain.
Gene ID: 9437 is NCR1 natural cytotoxicity triggering receptor 1 on 19q13.42.
- NP_001138929.2 natural cytotoxicity triggering receptor 1 isoform b precursor: "Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform b) compared to isoform a." Conserved Domains (2) summary: cd05711 Location: 123  210 Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI and cd05751 Location: 27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins.
- NP_001138930.2 natural cytotoxicity triggering receptor 1 isoform c precursor: "Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform c) compared to isoform a." Conserved Domains (2) summary: cd05711 Location: 123  210 Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI, cd05751 Location: 27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins.
- NP_001229285.1 natural cytotoxicity triggering receptor 1 isoform d precursor: "Transcript Variant: This variant (4) lacks an alternate exon in the 5' coding region compared variant 1. The resulting protein (isoform d) is shorter but has the same N- and C-termini compared to isoform a." Conserved Domains (1) summary: cd05711 Location: 28  115 Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI.
- NP_001229286.1 natural cytotoxicity triggering receptor 1 isoform e precursor: "Transcript Variant: This variant (5) lacks two alternate exons in the coding region compared to variant 1. The resulting protein (isoform e) is shorter but has the same N- and C-termini compared to isoform a." Conserved Domains (1) summary: cd05711 Location: 28  115 Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI.
- NP_004820.2 natural cytotoxicity triggering receptor 1 isoform a precursor: "Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a)." Conserved Domains (2) summary: cd05711 Location: 123  210 Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI and cd05751 Location: 27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins.
- XP_011525830.1 natural cytotoxicity triggering receptor 1 isoform X1, Conserved Domains (2) summary: cd05711 Location: 123  210 Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI and cd05751 Location: 27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins.
- XP_011525831.1 natural cytotoxicity triggering receptor 1 isoform X2, Conserved Domains (2) summary: cd05711 Location:123  210, Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI and cd05751 Location: 27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins.
- XP_011525832.1 natural cytotoxicity triggering receptor 1 isoform X3, Conserved Domains (2) summary: cd05711 Location: 123  210 Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI and cd05751 Location: 27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins.
Gene ID: 10859 is LILRB1 leukocyte immunoglobulin like receptor B1 on 19q13.42: "This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene."
- NP_001075106.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 2 precursor: "Transcript Variant: This variant (2) has a shorter 5' UTR and uses two alternate in-frame splice sites in the coding region, compared to variant 1. The resulting protein (isoform 2) is longer, compared to isoform 1." cd05751 Location: 27  119 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins, smart00410 Location: 335  397 IG_like; Immunoglobulin like, and cl11960 Location: 124  219 Ig; Immunoglobulin domain.
- NP_001075107.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 3 precursor: "Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region and differs in the 5' UTR, compared to variant 1. The resulting protein (isoform 3) is longer, compared to isoform 1." cd05751 Location: 27  119 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins, smart00410 Location: 335  397 IG_like; Immunoglobulin like, and cl11960 Location: 124  219 Ig; Immunoglobulin domain.
- NP_001075108.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 4 precursor: "Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region and differs in the 5' UTR, compared to variant 1. The resulting protein (isoform 4) is longer, compared to isoform 1." cd05751 Location: 27  119 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins, smart00410 Location: 335  397 IG_like; Immunoglobulin like, and cl11960 Location: 124  219 Ig; Immunoglobulin domain.
- NP_001265327.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 5 precursor: "Transcript Variant: This variant (5) has a shorter 5' UTR, lacks an internal in-frame exon, and uses an alternate splice site in the central coding region, compared to variant 1. The resulting protein (isoform 5) is shorter, compared to isoform 1." cd05751 Location: 27  119 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins, smart00410 Location: 335  397 IG_like; Immunoglobulin like, and cl11960 Location: 124  219 Ig; Immunoglobulin domain.
- NP_001265328.2 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 6 precursor: "Transcript Variant: This variant (6) has a shorter 5' UTR, lacks several exons, and its 3'-terminal exon extends past a splice site that is used in variant 1. The resulting protein (isoform 6) has a shorter and distinct C-terminus, compared to isoform 1. Isoform 6 lacks the transmembrane domain found in isoform 1 and is suspected to be soluble (PMID: 19658091)." cd05751 Location: 27  119 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins, smart00410 Location: 335  397 IG_like; Immunoglobulin like, and cl11960 Location: 124  219 Ig; Immunoglobulin domain.
- NP_006660.4 leukocyte immunoglobulin-like receptor subfamily B member 1 isoform 1 precursor: "Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1." cd05751 Location: 27  119 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins, smart00410 Location: 335  397 IG_like; Immunoglobulin like, and cl11960 Location: 124  219 Ig; Immunoglobulin domain.
Gene ID: 11006 is LILRB4 leukocyte immunoglobulin like receptor B4 on 19q13.42: "This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene."
- NP_001265355.2 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 1 precursor: "Transcript Variant: This variant (1) encodes isoform 1." cd05751 Location:27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins, smart00410 Location: 130  198 IG_like; Immunoglobulin like, and cl11960 Location: 123  217 Ig; Immunoglobulin domain.
- NP_001265356.2 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 2 precursor: "Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1." cd05751 Location:27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins, smart00410 Location: 130  198 IG_like; Immunoglobulin like, and cl11960 Location: 123  217 Ig; Immunoglobulin domain.
- NP_001265357.2 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 3 precursor: "Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the central and 3' coding region, compared to variant 1. The encoded isoform (3) is the same length, compared to isoform 1." cd05751 Location:27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins, smart00410 Location: 130  198 IG_like; Immunoglobulin like, and cl11960 Location: 123  217 Ig; Immunoglobulin domain.
- NP_001265358.2 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 4: "Transcript Variant: This variant (4) lacks an in-frame exon in the 5' coding region, uses an alternate in-frame splice site in the central coding region, and initiates translation at an upstream start codon, compared to variant 1. The encoded isoform (4) is longer and contains a distinct N-terminus, compared to isoform 1." cd05751 Location: 56  147 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins and cl11960 Location: 152  246 Ig; Immunoglobulin domain.
- NP_001265359.2 leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 5 precursor: "Transcript Variant: This variant (5) lacks several exons, and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (5) has a shorter and distinct C-terminus, compared to isoform 1. Isoform 5 lacks the transmembrane domain found in isoform 1 and is suspected to be soluble (PMID: 19658091)." cd05751 Location:27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins, smart00410 Location: 130  198 IG_like; Immunoglobulin like, and cl11960 Location: 123  217 Ig; Immunoglobulin domain.
Gene ID: 11024 is LILRA1 leukocyte immunoglobulin like receptor A1 on 19q13.42: "This gene encodes an activating member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein is predominantly expressed in B cells, interacts with major histocompatibility complex class I ligands, and contributes to the regulation of immune responses. Alternative splicing results in multiple transcript variants encoding different isoforms."
- NP_001265247.1 leukocyte immunoglobulin-like receptor subfamily A member 1 isoform 2 precursor: "Transcript Variant: This variant (2, also known as LIR6b) lacks two consecutive in-frame exons in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1." cd05751 Location: 27  119 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins and cl11960 Location: 124  219 Ig; Immunoglobulin domain.
- NP_001265248.1 leukocyte immunoglobulin-like receptor subfamily A member 1 isoform 3 precursor: "Transcript Variant: This variant (3) has a shorter 5' UTR, lacks several exons and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1. Isoform 3 lacks the transmembrane domain found in isoform 1 and is suspected to be soluble (PMID: 19658091)." cd05751 Location: 27  119 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins, smart00410 Location: 335  397 IG_like; Immunoglobulin like, and cl11960 Location: 124  219 Ig; Immunoglobulin domain.
- NP_006854.1 leukocyte immunoglobulin-like receptor subfamily A member 1 isoform 1 precursor: "Transcript Variant: This variant (1, also known as LIR6a) represents the longest transcript and encodes the longest isoform (1)." cd05751 Location: 27  119 Ig1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains and cl11960 Location: 124  219 Ig; Immunoglobulin domain.
Gene ID: 11025 is LILRB3 leukocyte immunoglobulin like receptor B3 on 19q13.42: "This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene."
- NP_001074919.2 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform 1 precursor , cd05751 Location: 27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins and cl11960 Location: 123  217 Ig; Immunoglobulin domain.
- NP_001307889.1 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform 3 precursor , cd05751 Location: 27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins and cl11960 Location: 123  217 Ig; Immunoglobulin domain.
- NP_006855.3 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform 2 precursor , cd05751 Location: 27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins and cl11960 Location: 123  217 Ig; Immunoglobulin domain.
Gene ID: 11026 is LILRA3 leukocyte immunoglobulin like receptor A3 on 19q13.4: "This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the transmembrane region found in other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region."
- NP_001166125.1 leukocyte immunoglobulin-like receptor subfamily A member 3 isoform 2 precursor: "Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1." cd05751 Location: 27  119 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins, smart00410 Location: 271  333 IG_like; Immunoglobulin like, and cl11960 Location: 261  355 Ig; Immunoglobulin domain.
- NP_006856.3 leukocyte immunoglobulin-like receptor subfamily A member 3 isoform 1 precursor: "Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)." cd05751 Location: 27  119 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins, smart00410 Location: 335  397 IG_like; Immunoglobulin like, and cl11960 Location: 124  219 Ig; Immunoglobulin domain.
Gene ID: 51206 is GP6 glycoprotein VI platelet on 19q13.42: "This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene."
- NP_001077368.2 platelet glycoprotein VI isoform 1 precursor: "Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)." Conserved Domains (2) summary: cd05751 Location: 26  108 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins and cl11960 Location: 113  202 Ig; Immunoglobulin domain.
- NP_001242946.2 platelet glycoprotein VI isoform 3 precursor: "Transcript Variant: This variant (3) lacks an exon and uses an alternate splice site in the 3' coding region, compared to variant 1, that results in a frameshift. It encodes isoform 3 which has a shorter and distinct C-terminus compared to isoform 1." Conserved Domains (2) summary: cd05751 Location: 26  108 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins and cl11960 Location: 113  202 Ig; Immunoglobulin domain.
- NP_057447.5 platelet glycoprotein VI isoform 2 precursor: "Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, that results in a frameshift. It encodes isoform 2 which has a shorter and distinct C-terminus compared to isoform 1." Conserved Domains (2) summary: cd05751 Location: 26  108 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins and cl11960 Location: 113  202 Ig; Immunoglobulin domain.
Gene ID: 79168 is LILRA6 leukocyte immunoglobulin like receptor A6 on 19q13.42.
- NP_001347096.1 leukocyte immunoglobulin-like receptor subfamily A member 6 precursor cd05751 Location: 27  118 Ig1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains, cl11960 Location: 123  217 Ig; Immunoglobulin domain.
- NP_077294.3 leukocyte immunoglobulin-like receptor subfamily A member 6 precursor: "Transcript Variant: This variant (1) encodes the supported protein". cd05751 Location: 27  118 Ig1_LILR_KIR_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILRs), Natural killer inhibitory receptors (KIRs) and similar domains,  smart00410 Location: 237  296 IG_like; Immunoglobulin like and cl11960 Location: 123  217 Ig; Immunoglobulin domain.
Gene ID: 353514 is LILRA5 leukocyte immunoglobulin like receptor A5 on 19q13.42: "The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described."
- NP_067073.1 leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 1 precursor: "Transcript Variant: This variant (1), also known as LIR9m1, encodes the longest isoform (1)." cd05711 Location: 141  236 Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI and cd05751 Location: 45  136 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins.
- NP_870994.1 leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 3: "Transcript Variant: This variant (3), also known as LIR9s1, differs in the 3' end-region, which includes a part of the coding region, as compared to variant 1. The resulting isoform (3) has a distinct and shorter C-terminus, as compared to isoform 1." cd05711 Location: 141  236 Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI and cd05751 Location: 45  136 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins.
- NP_871714.1 leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 2: "Transcript Variant: This variant (2), also known as LIR9m2, lacks an in-frame coding segment, as compared to variant 1. The resulting isoform (2) lacks an internal region, as compared to isoform 1." cd05711 Location: 129  224 Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI and cd05751 Location: 33  124 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins.
- NP_871715.1 leukocyte immunoglobulin-like receptor subfamily A member 5 isoform 4: "Transcript Variant: This variant (4), also known as LIR9s2, lacks an in-frame coding segment and differs in the 3' end-region, as compared to variant 1. The resulting isoform (4) lacks an internal region and has a distinct and shorter C-terminus as compared to isoform 1." cd05711 Location: 129  224 Ig_FcalphaRI; Immunoglobulin (IG)-like domain of of FcalphaRI and cd05751 Location: 33  124 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins.
Gene ID: 102725035 is LOC102725035 leukocyte immunoglobulin-like receptor subfamily B member 3 on 19.
- XP_006726377.1 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X4, Conserved Domains (3) summary: cd05751 Location: 27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins, smart00410 Location: 237  296 IG_like; Immunoglobulin like and cl11960 Location: 123  217 Ig; Immunoglobulin domain.
- XP_006726376.1 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X3, Conserved Domains (3) summary: cd05751 Location: 27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins, smart00410 Location: 237  296 IG_like; Immunoglobulin like, cl11960 Location: 123  217 Ig; Immunoglobulin domain.
- XP_011546877.1 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X2, Conserved Domains (3) summary: cd05751 Location: 27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins, smart00410 Location: 237  296 IG_like; Immunoglobulin like and cl11960 Location: 123  217 Ig; Immunoglobulin domain.
- XP_011546876.1 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X1, Conserved Domains (3) summary: cd05751 Location: 27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins, smart00410 Location: 237  296 IG_like; Immunoglobulin like and cl11960 Location: 123  217 Ig; Immunoglobulin domain.
Gene ID: 107987425 is LOC107987425 leukocyte immunoglobulin-like receptor subfamily B member 3 on 19.
- XP_006726343.1 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X5, Conserved Domains (3) summary: cd05751 Location: 27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins, smart00410 Location: 334  396 IG_like; Immunoglobulin like and cl11960 Location: 123  217 Ig; Immunoglobulin domain.
- XP_006726341.1 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X4, Conserved Domains (3) summary: cd05751 Location: 27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins, smart00410 Location: 334  396 IG_like; Immunoglobulin like and cl11960 Location: 123  217 Ig; Immunoglobulin domain.
- XP_011545353.1 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X3, Conserved Domains (3) summary: cd05751 Location: 27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins and smart00410 Location: 334  396 IG_like; Immunoglobulin like and cl11960 Location: 123  217 Ig; Immunoglobulin domain.
- XP_011545352.1 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X2, Conserved Domains (3) summary: cd05751 Location: 27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins, smart00410 Location: 334  396 IG_like; Immunoglobulin like and cl11960 Location: 123  217 Ig; Immunoglobulin domain.
- XP_011545360.1 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X1, Conserved Domains (3) summary: cd05751 Location: 27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins, smart00410 Location: 334  396 IG_like; Immunoglobulin like and cl11960 Location: 123  217 Ig; Immunoglobulin domain.
Gene ID: 107987462 is LOC107987462 leukocyte immunoglobulin-like receptor subfamily B member 3 on 19.
- XP_016885786.1 leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X4, Conserved Domains (2) summary: cd05751 Location: 27  118 Ig1_LILRB1_like; First immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors (LILR)B1 (also known as LIR-1) and similar proteins and cl11960 Location: 123  217 Ig; Immunoglobulin domain.

# Hypotheses
- Downstream core promoters may work as transcription factors even as their complements or inverses.
- In addition to the DNA binding sequences listed above, the transcription factors that can open up and attach through the local epigenome need to be known and specified.
- The function of A1BG is the same as other immunoglobulin genes possessing the immunoglobulin domain cl11960 and/or any of three immunoglobulin-like domains: pfam13895, cd05751 and smart00410 in the order and nucleotide sequence: cd05751 Location: 401  493, smart00410 Location: 218  280, pfam13895 Location: 210  301 and cl11960 Location: 28  110.