Myocardial rupture overview

# Overview
Myocardial rupture is a laceration or tearing of the walls of the ventricles or atria of the heart, of the interatrial or interventricular septum, of the papillary muscles or chordae tendineae or of one of the valves of the heart.  It is most commonly seen as a serious sequelae of an acute myocardial infarction (heart attack).

# Pathophysiology
The most common cause of myocardial rupture is a recent myocardial infarction, with the rupture typically occurring three to five days after infarction. Other causes of rupture include cardiac trauma, endocarditis (infection of the heart), cardiac tumors, infiltrative diseases of the heart, and aortic dissection.

# Epidemiology and Demographics
The incidence of myocardial rupture has decreased in the era of urgent revascularization and aggressive pharmacological therapy for the treatment of an acute myocardial rupture.  However, the decrease in the incidence of myocardial rupture is not uniform; there is a slight increase in the incidence of rupture if thrombolytic agents are used to abort a myocardial infarction.  On the other hand, if primary percutaneous coronary intervention is performed to abort the infarction, the incidence of rupture is significantly lowered.  The incidence of myocardial rupture if PCI is performed in the setting of an acute myocardial infarction is about 1 percent.

# Risk Factors
Risk factors for rupture after an acute myocardial infarction include female gender, advanced age of the individual, and a low body mass index.  Other presenting signs associated with myocardial rupture include a pericardial friction rub, sluggish flow in the coronary artery after it is opened, the left anterior descending artery being the cause of the acute MI, and delay of revascularization greater than 2 hours.

# Natural History, Complications and Prognosis
The prognosis of myocardial rupture is dependant on a number of factors, including which portion of the myocardium is involved in the rupture.  In one case series, if myocardial rupture involved the free wall of the left ventricle, the mortality rate was 100 percent. Even if the individual survives the initial hemodynamic sequelae of the rupture, the 30 day mortality is still significantly higher than if rupture did not occur.

# Diagnosis

## History and Symptoms
Symptoms of myocardial rupture are recurrent or persistent chest pain, syncope, and distension of jugular veins. Due to the acute hemodynamic deterioration associated with myocardial rupture, the diagnosis is generally made based on physical examination, changes in the vital signs, and clinical suspicion.  The diagnosis can be confirmed with echocardiography.

## Physical Examination
Due to the acute hemodynamic deterioration associated with myocardial rupture, the diagnosis is generally made based on physical examination, changes in the vital signs, and clinical suspicion.

## Echocardiography
The diagnosis can be confirmed with echocardiography.

# Treatment

## Medical Therapy
The treatment for myocardial rupture is supportive in the immediate setting and surgical correction of the rupture, if feasible. A certain small percentage of individuals do not seek medical attention in the acute setting survive.  In this setting, it may be reasonable to treat the rupture medically and delay or avoid surgery completely, depending on the individual's comorbid medical issues.

## Surgery
The treatment for myocardial rupture is supportive in the immediate setting and surgical correction of the rupture, if feasible. A certain small percentage of individuals do not seek medical attention in the acute setting survive.  In this setting, it may be reasonable to treat the rupture medically and delay or avoid surgery completely, depending on the individual's comorbid medical issues.