Twenty recommendations have been changed or updated and the overall number of recommendations brought down to 74 from 89. - The main topic areas of change in this updated version are in lifestyle management, risk-factor screening and risk stratification, and treatment targets for dyslipidemia, particularly for individuals at high risk, such as those with high-risk kidney disease.# I
n Canada, the multiple chronic conditions and cardiovascular risk factors of our aging population continue to challenge health care providers and burden health systems. Cardiovascular disease is a major contributor to chronic illness, with four in five Canadians having at least one risk factor for cardiovascular disease and 16% having three or more risk factors. 1 In their first-line role, primary care practitioners bear a substantial proportion of the responsibility and patient care load associated with managing risk factors for cardiovascular disease.
Clinical practice guidelines can assist health care practitioners by synthesizing the best available evidence with the use of robust procedures for guideline development, resulting in clear recommendations to guide medical decisionmaking. When this science of medicine intersects with the art of clinical practice, optimal patient care may result. 2 In 2011, contributors to the Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE) created Canada's first harmonized guideline for cardiovascular risk factors. 3 Using a consensus process, the 2011 C-CHANGE Guideline Panel accepted 89 key recommendations related to cardiovascular disease from more than 400 existing recommendations sourced from eight different guideline groups. 3 The 2014 update is a harmonized subset of recommendations from the following guideline groups: Canadian Action Network for the Advancement, Dissemination and Adoption of Practice-informed Tobacco Treatment; 4 Canadian Association of Cardiac Rehabilitation; 5 Canadian Cardiovascular Society; 6 Canadian Diabetes Association; 7 Canadian Hypertension Education Program; 8 Canadian Society for Exercise Physiology; 9 Heart and Stroke Foundation Canadian Stroke Best Practice Recommendations; 10 and Obesity Canada. 11 The C-CHANGE Guideline Panel updates its harmonized guideline when the constituent guideline groups release new critically important recommenda-tions or a sufficient number of guideline groups have updated their recommendations.
The 2011 C-CHANGE guideline provided specific recommendations for screening, diagnostic and risk-stratification strategies, treatment targets, health-behaviour recommendations and pharmacologic treatments. Challenges in updating the C-CHANGE guideline include the varying time frames of updates and different grading schemes used by each guideline group.
The opportunity presented by the C-CHANGE process includes both the harmonization of overlapping clinical practice recommendations from each of the member groups and the potential integration of the guideline development process. The primary aim of the 2011 C-CHANGE guideline was to develop the harmonization methodology and to produce the first set of harmonized recommendations for prevention and management of cardiovascular disease in primary care. The goal of this second iteration was to establish the integrated review cycle and to demonstrate that guideline groups with harmonized recommendations through C-CHANGE could work collectively to ensure that these recommendations would remain harmonized after the update.
In this paper, we highlight the new and important changes in the 2014 C-CHANGE recommendations. The target audience is the primary care community, including primary care physicians, nurses, nurse practitioners, pharmacists, dietitians and other health care providers, who care for patients with or at risk for vascular disease, such as cardiovascular and cerebrovascular disease. The target population is adults (aged  18 yr). We describe the C-CHANGE model of harmonization, the integration of the review cycle, and the implementation and dissemination program.
One of the challenges of practice guidelines is the risk that they will be considered all-encompassing statements with respect to patient care, rather than a collection of evidence-informed recommendations, all or some of which apply to individual patients. The decision to implement a specific recommendation should be tailored to the individual circumstances of each patient. The recommendations contained herein are intended to guide practitioners, but are not meant to replace sound clinical judgment. We recognize that it is the role of clinicians, who best know their patients, to determine whether a recommendation does or does not apply in a certain circumstance; further, we expect that the clinician is able to explain why a recommendation may or may not apply. The recommendations should therefore be considered as a set of sign posts that help health care practitioners achieve best practices for their patients and clients.
Recent major updates in the guidelines for hypertension, diabetes, lipids and stroke triggered this second iteration of the C-CHANGE guideline.

# Guideline panel composition
The C-CHANGE Guideline Panel consisted of the lead, chair, co-chair, or a person who held this role or a similar role for each of the individual guideline organizations. Participants had to be a volunteer in their respective organizations, have an academic appointment at a Canadian institution, and be an acknowledged expert in their field based on peer-reviewed publications and reputation. All conflicts of interest were declared beforehand. The C-CHANGE Guideline Panel operates primarily through teleconferences and email with one face-to-face meeting, drawing on funds provided by the Public Health Agency of Canada and Ontario Ministry of Health and Long-term Care.

# Guideline development
The objective of the 2014 C-CHANGE guideline was to update the 2011 version to be consistent with recent updates made by the C-CHANGE partner guideline groups. This meant replacing recommendations that changed in the partner guidelines (Table 1). The revised list of updated recommendations was then reviewed and approved. In a second round of review, recommendations that were deemed redundant were removed after approval by the C-CHANGE Guideline Panel.
An integrated review cycle was developed in collaboration with each of the guideline groups. The review process was initiated in the year following updates to the guidelines from the Canadian Diabetes Association, Canadian Cardiovascular Society (dyslipidemia guideline), and the Canadian Hypertension Education Program. The first version (2011) of the C-CHANGE recommendations was circulated to the leaders of each of the eight guideline groups to identify key upcoming changes in their individual updates. The C-CHANGE Guideline Panel requested that the leadership of each guideline group develop or reconfirm memoranda of understanding among all the groups for a harmonization process for the C-CHANGE recommendations.
Shared working groups were developed to evaluate the evidence (including systematic reviews and grading of evidence), to ensure that shared guidelines had consistent wording for each guideline group, with the goal of being patient-centred and actionable. These summaries are available through the individual guideline groups. For example, in harmonizing a recommendation for blood pressure control in people with diabetes, the scientists who developed the individual recommendations for the diabetes and hypertension groups agreed to accept these recommendations without altering the wording. Another example was seen with the statin recommendation for people with diabetes which is the same in both the diabetes guideline 6 and dyslipidemia guideline. 5 Members of the C-CHANGE Guideline Panel worked with the individual guideline groups to verify that they had sufficient methodologic expertise in the critical appraisal process to ensure methodologic rigor and freedom from conflicts of interest in assessing the evidentiary strength of the recommendations. 12,13 Finally, the C-CHANGE process ensured the wording of the recommendations was consistent with the evidence and could be applied in practice.
Guideline groups may approach the assignment of evidentiary strength differently. Some use the full GRADE (Grading of Recommendations Assessment, Development and Evaluation) system; 14 others use a modified approach. However, all C-CHANGE recommendations are considered to be "strong" in nature, and C-CHANGE does not make "weak" recommendations. Thus, as an example, the grading scheme of the Canadian - To decrease blood pressure, consider reducing sodium intake toward 2000 mg (5 g of salt) per day. CHEP
- All individuals should be encouraged to adopt healthy eating habits to lower their risk of cardiovascular disease: 1) moderate energy (caloric) intake to achieve and maintain a healthy body weight; 2) emphasize a diet rich in vegetables, fruit, whole-grain cereals and polyunsaturated and monounsaturated oils, including omega-3 fatty acids particularly from fish; 3) avoid trans fats, limit saturated and total fats to  30 g; 5) limit cholesterol intake to 200 mg daily for individuals with dyslipidemia or at increased risk of cardiovascular disease.

# CCS People with diabetes
- People with diabetes should be offered timely diabetes education that is tailored to enhance self-care practices and behaviours.

# Risk-factor screening
Target population 
- Screening for diabetes using FPG and/or A 1c should be performed every 3 yr in individuals  40 yr of age or at high risk using a risk calculator. More frequent and/or earlier testing with either FPG and/or A 1c or 2hPG in a 75-g OGTT should be considered in those at very high risk using a risk calculator or in people with additional risk factors for diabetes. These risk - Testing with 2hPG in a 75-g OGTT should be undertaken in individuals with FPG 6.1-6.9 mmol/L and/or A 1c 6.0%-6.4% to identify individuals with IGT or diabetes.

# Risk stratification
Target population 
- We recommend that a cardiovascular risk assessment, using the "10-year risk" provided by the Framingham model, be completed every 3-5 yr for men aged 40-75 and women aged 50-75 yr. This should be modified (percent risk doubled) when family history of premature cardiovascular disease is positive (i.e., first-degree relative aged < 55 yr for men and < 65 yr for women). A risk assessment might also be completed whenever a patient's expected risk status changes.
Younger individuals with at least 1 risk factor for premature cardiovascular disease might also benefit from a risk assessment to motivate them to improve their lifestyle.
- We recommend calculating and discussing a patient's "cardiovascular age" to improve the likelihood that patients will reach lipid targets and that poorly controlled hypertension will be treated.  Hypertension Education Program refers only to the quality of evidence and not to the relative strength of the recommendation, because all are considered strong recommendations. 15 Additionally, guideline groups develop guidelines with a "strong intent." A recommendation with strong intent is defined by the National Institute for Health and Care Excellence (formerly the National Institute for Health and Clinical Excellence; NICE), as one that most people would follow if they had a good working knowledge of the issues. 16 Given the NICE criterion, a recommendation based on the consensus of a group of national experts in the area could be considered of strong intent, even though the evidence base was weak (e.g., absence of randomized controlled trials. Efforts are made to limit the number of these consensus recommendations, because of the risk of introducing bias or agendas.
The evidence required for specific types of recommendations varies. For drug therapy recommendations, a strong evidentiary base is required with RCTs with measurable outcomes and excellent internal validity. Health behaviour recommendations are permitted to be based on RCTs with surrogate outcomes (i.e., blood glucose or blood pressure levels). Diagnostic recommendations are based on prospective studies demonstrating that the diagnostic test is predictive of measurable outcomes. A cost analysis was not included because we believe that the assumptions required are best made by the individual jurisdictions implementing the recommendations.
The updated C-CHANGE guideline has been streamlined to include 74 recommendations, down from 89. These include 20 recommendations that are new or have been updated for 2014 and primarily reflect the updated Canadian Diabetes Association guideline and the Canadian Cardiovascular Society's dyslipidemia guideline. The updated recommendations are found in Table 1 and Appendix 1 (available at www.cmaj.ca /lookup/suppl/doi:10.1503/cmaj.140387 /-/DC1).
The implementability (e.g., clarity, simplicity and format) of the recommendations remains an ongoing process, with a target of applying it to all the C-CHANGE recommendations by the next cycle. 17 Details of the recommendations are found in Appendix 1, including the associated guideline group, evidence supporting each recommendation and references.
The Appraisal of Guidelines for Research and Evaluation (AGREE II) tool is used to assess the quality and reporting of a set of practice guide-lines. 12 Appendix 2 (available at www.cmaj.ca /lookup/suppl/doi:10.1503/cmaj.140387/-/DC1) provides an AGREE II assessment of this guideline. The assessment should help guideline users evaluate the C-CHANGE guideline and the C-CHANGE process itself to evolve and to continue to improve.

# Implementation and evaluation
Guideline dissemination and implementation has the potential to integrate best available evidence into practice, to reduce inconsistencies, to minimize harm, to facilitate interdisciplinary collaboration between specialists and generalists and interprofessional collaboration between physicians and other members of the health care team, and to ultimately improve overall quality of care.  However, there is inconsistent evidence to support which implementation strategies are most likely to facilitate the use of guidelines in practice. 19,21,22 Multiple strategies seem to hold the most promise. 23 Implementation strategies developed by the C-CHANGE Initiative can be found in Box 1. The C-CHANGE process facilitates the sharing of implementation strategies among the participating guideline groups. More information on implementation is found in Appendix 3 (available at www.cmaj.ca/lookup/suppl/doi:10.1503/cmaj.140387 /-/DC1).
C-CHANGE collaborates with various provinces and the eight guideline partners to create C-CHANGE practice tools and programs that ensure the principles of harmonization are upheld. These principles are as follows: that the tools and programs are consistent and not fragmented, that they are of high quality and are measurable, that there is fidelity with the C-CHANGE clinical recommendations and decision support process, and that they are aligned provincially and nationally.
Ongoing efforts by the C-CHANGE Initiative have resulted in a set of recommendations that provide a single authoritative source for recommendations for most primary care management for vascular disease. This was only possible with the direct participation and partnership with each individual guideline group. Between now and the next cycle, which will again be chosen strategically to coincide with major changes in the component recommendations, efforts will focus on harmonizing implementation processes with the individual guideline groups. The C-CHANGE Initiative will undertake to work with ministries of health and clinical service providers to integrate the C-CHANGE recommendations seamlessly into electronic medical record systems.
The entire list of recommendations is available in Appendix 1.

# How you can get involved in the CMA!
The CMA is committed to providing leadership for physicians and promoting the highest standard of health and health care for Canadians. To strengthen the association and be truly representative of all Canadian physicians the CMA needs to hear from members interested in serving in elected positions and on appointed committees and advisory groups. The CMA structure comprises both governing bodies and advisory bodies either elected by General Council or appointed by the CMA Board of Directors. The Board of Directors -elected by General Council -has provincial/territorial, resident and student representation, is responsible for the overall operation of the CMA and reports to General Council on issues of governance.
CMA committees advise the Board of Directors and make recommendations on specific issues of concern to physicians and the public. Five core committees mainly consist of regional, resident and student representation while other statutory and special committees and task forces consist of individuals with interest and expertise in subject-specific fields. Positions on one or more of these committees may become available in the coming year.
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