Diabetes Care for Emerging Adults: Recommendations for Transition From Pediatric to Adult Diabetes Care Systems

 [bib_ref] SEARCH for Diabetes in Youth Study Group. The burden of diabetes mellitus..., Liese [/bib_ref] 

## Rates of diabetes during
Worldwide, the prevalence of type 1 diabetes in children and young adults has doubled in the past 25 years and is expected to double yet again in the next 15-20 years, a phenomenon not observed several decades ago [bib_ref] Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and..., Patterson [/bib_ref]. The epidemic of childhood obesity has lead to an increased incidence of type 2 diabetes being diagnosed in children and teenagers [bib_ref] The global spread of type 2 diabetes mellitus in children and adolescents, Pinhas-Hamiel [/bib_ref]. Type 2 diabetes remains relatively uncommon in children under age 10 years, with the majority of cases identified in youth during the 2nd decade of life and affecting predominantly those from racial and/or ethnic minority groups, namely American Indians, blacks, Hispanics, Asians, and Pacific Islanders [bib_ref] Diabetes in Navajo youth: prevalence, incidence, and clinical characteristics: the SEARCH for..., Dabelea [/bib_ref] [bib_ref] Diabetes in African American youth: prevalence, incidence, and clinical characteristics: the SEARCH..., Mayer-Davis [/bib_ref] [bib_ref] SEARCH for Diabetes in Youth Study Group. Type 1 and Type 2..., Liu [/bib_ref] [bib_ref] Diabetes in non-Hispanic white youth: prevalence, incidence, and clinical characteristics: the SEARCH..., Bell [/bib_ref]. Furthermore, although the incidence of type 1 diabetes declines toward the middle to the late 2nd decade of life (age 15-19 years) from the peak rates observed during puberty in early adolescence, the incidence of type 2 diabetes continues to increase with age.
There are limited epidemiological data that span the age range from late adolescence through young adulthood (18-30 years of age), although there are data that precede and follow this key developmental period. The SEARCH study provides prevalence estimates for 15-to 19-yearolds in various racial and ethnic populations [bib_ref] Diabetes in Navajo youth: prevalence, incidence, and clinical characteristics: the SEARCH for..., Dabelea [/bib_ref] [bib_ref] Diabetes in African American youth: prevalence, incidence, and clinical characteristics: the SEARCH..., Mayer-Davis [/bib_ref] [bib_ref] SEARCH for Diabetes in Youth Study Group. Type 1 and Type 2..., Liu [/bib_ref] [bib_ref] Diabetes in non-Hispanic white youth: prevalence, incidence, and clinical characteristics: the SEARCH..., Bell [/bib_ref]. Prevalence of type 1 diabetes for this age-group ranges from 0.43 per 1,000 in Navajo youth to 3.22 per 1,000 in non-Hispanic whites, while the prevalence of type 2 diabetes ranges from 0.29 (non-Hispanic whites) to 2.36 (Navajo) per 1,000. In a survey of 11,855 young adults (41% response rate), ages 18-29 years, attending 2-year and 4-year postsecondary educational institutions in Minnesota, 0.55% of students reported having a diagnosis of type 1 diabetes (E. Ehlinger, personal communication).
The size of the young adult population with diabetes is difficult to know with certainty. The overall numbers of children, adolescents, and young adults with diabetes in the U.S. in 2007 was estimated at close to a million in a study of diabetes costs including the age-groups ,18 and 18-34. Given the current estimates of the prevalence of diabetes in youth, one can expect that each year there are tens of thousands of emerging young adults with type 1 or type 2 diabetes who will be transitioning from pediatric to adult care.
EMERGING ADULTHOODdFor the purposes of this statement, we have chosen to focus on the age range of 18-30 years. The preceding period of adolescent growth and development is a stage of tremendous physical, social, and emotional change that challenges diabetes management for both youth and health care providers. During this stage of adolescent development, there is a need for ongoing family involvement in diabetes management in order to reduce the risk of deterioration in glycemic control that often accompanies adolescence [bib_ref] Impact of ambulatory, family-focused teamwork intervention on glycemic control in youth with..., Laffel [/bib_ref].
In contrast to the views of traditional developmental psychology, contemporary thinking is that young adulthood does not immediately follow adolescence, but begins when youth are in their late 20s or early 30s and that the developmental stage between ages ;l8 and 30 years defines a period called emerging adulthood [bib_ref] Emerging adulthood. A theory of development from the late teens through the..., Arnett [/bib_ref]. Recent cultural trends in America suggest that young people in their 20s delay assuming adult roles with respect to marriage, parenting, and work compared with young adults in earlier generations. Contemporary developmental theorist J.J. Arnett [bib_ref] Emerging adulthood. A theory of development from the late teens through the..., Arnett [/bib_ref] suggests that the postadolescent period is subdivided into an early phase corresponding to the years immediately after high school (;18-24 years) and a later phase when more traditional adult roles are assumed (;25-30 years). Thinking about the postadolescent period as consisting of two phases provides a valuable framework when considering diabetes management and may help to ensure that the clinician's approach and focus are appropriately matched to the emerging adult's life circumstances and readiness to become an active participant in his/her own diabetes management.
During the early phase of emerging adulthood, the person may be transitioning geographically, economically, and emotionally away from the parental home. Competing academic, economic, and social priorities often detract from a focused commitment to chronic disease management. Even as young adults face these competing demands, most do not believe that they have achieved all of the skills necessary to remain independent and accept these responsibilities on their own [bib_ref] Emerging adulthood. A theory of development from the late teens through the..., Arnett [/bib_ref]. Therefore, it may be unrealistic to expect the person with diabetes in the first phase of emerging adulthood to make major changes in their diabetes management strategies, or even to transition to a new adult diabetes health care provider. Conversely, for many this early phase is marked by feelings of invulnerability and a tendency to reject adult control, which may further limit receptiveness to recommendations for diabetes treatment.
During the second phase of the young adult period, the 25-to 30-year-old often has a maturing sense of identity and assumes adult-like roles in society, such as entering into stable intimate relationships or full-time employment. This phase, when the individual starts making plans about his/her future life, is often accompanied by a growing recognition of the importance of striving for better glycemic control and receptiveness to improving self-care behavior. Life partners can be important supports and agents for change, and a shared sense of investment in the future will often catalyze this change in self-care behavior. This period, when lifelong patterns of behavior are likely established, can be a critical window of opportunity for health care interventions.

## Issues in the transition between pediatric and
ADULT DIABETES CAREdThe transition from pediatric to adult diabetes care represents a high-risk period for a person with diabetes, a perfect storm during which interruption of care is likely for multiple reasons. The young person is leaving what has often been a longterm, comfortable relationship with health care providers, sometimes without preparation or ready access to a subsequent provider. There are also multiple psychosocial adjustments during the postadolescent period of emerging adulthood that can be confounded by financial stressors. Poor glycemic control, the presence of risk factors for complications (hypertension and dyslipidemia), highrisk behaviors (cigarette smoking and drug and/or alcohol abuse), and emerging complications may further increase the difficulty of this period. The period of emerging adulthood may be accompanied by uncertainty regarding health insurance coverage upon completing education or leaving the parental home. Given that individuals in this transition period have had the highest rates of uninsurance or underinsurance in the past, the reforms of the Patient Protection and Accountable Care Act in the U.S. should be of particular benefit to emerging adults with chronic conditions such as diabetes.
The following sections elaborate on eight areas of particular relevance for the emerging young adult with diabetes: differences between pediatric and adult care, poor glycemic control, loss to follow-up care, acute complications, psychosocial issues, reproductive health issues, substance use and abuse, and chronic complications.

## Differences between pediatric and adult care
There are fundamental differences in the approach and delivery of diabetes care between pediatric and adult patients. Diabetes care for pediatric patients requires involvement of the family in order to be successful. Young children do not have the cognitive ability to master diabetes management, and teens often do not possess the emotional maturity to sustain the tasks of daily therapy. Although health care delivery varies by system and access, in the pediatric health care setting, visits tend to be family-focused, holistic, and centered on management approaches that fit diabetes into the child and family's lifestyle. Diabetes visits and management approaches include parents/guardians as well as the youth.
In adult care, the focus is more on the autonomously functioning individual patient, who can be informed or counseled but then is expected to make his/her own choices about behavior or treatments. Adult visits tend to be substantially shorter and focused on medical problems. Adult patients choose who they do and do not want to have access to their health information and are largely considered independent consumers of health care. Whereas individuals change gradually from childhood to adulthood, the change in health care provider can be abrupt and unsettling, suggesting that a more gradual transition may be preferable.

## Poor control of glycemia and other risk factors
There remains a considerable gap between the recommended glycemic control levels and the levels actually achieved in clinical practice, especially for older teens and young adults. The SEARCH for Diabetes in Youth study showed that only 32% of youth with type 1 diabetes aged 13-18 years and 18% of those aged $19 years achieved ADA-recommended A1C targets [bib_ref] Glycemic control in youth with diabetes: the SEARCH for diabetes in Youth..., Petitti [/bib_ref]. On the other hand, National Health and Nutrition Examination Survey data reveal that 56% of adults achieve target A1C values of ,7% [bib_ref] Is glycemic control improving in U.S. adults?, Hoerger [/bib_ref]. The greatest proportion of youth with type 1 or type 2 diabetes in poor glycemic control (A1C $9.5%) were teenagers; one of every four patients aged .12 years had such elevated A1C levels [bib_ref] Glycemic control in youth with diabetes: the SEARCH for diabetes in Youth..., Petitti [/bib_ref]. Others have documented poor glycemic control during the older teen and young adult years [bib_ref] Poor prognosis of young adults with type 1 diabetes: a longitudinal study, Bryden [/bib_ref] [bib_ref] Diabetes Control and Complications Trial/ Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC)..., Nathan [/bib_ref]. Those in the poorest glycemic control are at high risk for both acute complications and chronic microvascular complications [bib_ref] Diabetes Control and Complications Trial/ Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC)..., Nathan [/bib_ref] [bib_ref] Predictors of acute complications in children with type 1 diabetes, Rewers [/bib_ref].
The prevalence of cardiovascular risk factors is much greater in youth with type 2 versus type 1 diabetes, regardless of ethnicity [bib_ref] Prevalence of cardiovascular disease risk factors in U.S. children and adolescents with..., Rodriguez [/bib_ref]. However, as the general obesity rates among all U.S. children and adolescents increase, youth with type 1 diabetes have experienced similarly increasing rates and may have additional cardiovascular risk, partly as a result of the suboptimal diets reported in youth with either type 1 or type 2 diabetes [bib_ref] SEARCH for Diabetes in Youth Study Group. Dietary intake among youth with..., Mayer-Davis [/bib_ref]. Studies show higher rates of dyslipidemia in obese children and adolescents with type 2 diabetes [bib_ref] Prevalence of cardiovascular disease risk factors in U.S. children and adolescents with..., Rodriguez [/bib_ref] [bib_ref] Lipid abnormalities are prevalent in youth with type 1 and type 2..., Kershnar [/bib_ref] [bib_ref] SEARCH for Diabetes in Youth Study Group. Prevalence of overweight and obesity..., Liu [/bib_ref]. Elevated lipid levels in youth with type 1 diabetes appear to be related to level of glycemic control [bib_ref] Lipid and lipoprotein profiles in youth with and without type 1 diabetes:..., Guy [/bib_ref]. The rates of hypertension in children and adolescents with diabetes compared with those without diabetes are largely related to overweight or obesity status. Fatty liver disease is also more common among obese children with insulin resistance and diabetes, may precede the diagnosis of type 2 diabetes, and has also been linked to type 1 diabetes [bib_ref] TODAY Study Group. Characteristics of adolescents and youth with recent-onset type 2..., Copeland [/bib_ref]. Progression and optimal treatment of fatty liver disease is not known in adolescents, but the disease can progress to cirrhosis and death. These risk factors need to be addressed in the adolescent and transitioning young adult.
Loss to follow-up The competing distractions of young adult life often interfere with the requirements of successful diabetes management, including the need to maintain consistent medical care. Transitioning older teens and young adults are at high risk for disengagement from health care and, in turn, the emergence of complications that may go undetected without appropriate follow-up diabetes care and screening. There are adverse short-term (hypoglycemia, hyperglycemia, or diabetic ketoacidosis [DKA]) and long-term (nephropathy and retinopathy) outcomes when patients with diabetes are lost to follow-up or have infrequent encounters [bib_ref] Predictors of acute complications in children with type 1 diabetes, Rewers [/bib_ref] [bib_ref] The changing natural history of nephropathy in type I diabetes, Krolewski [/bib_ref] [bib_ref] Consequences of irregular versus continuous medical follow-up in children and adolescents with..., Jacobson [/bib_ref]. Rates of hospitalization and emergency use and costs of care are higher when glycemic control is poor [bib_ref] Predictors of acute complications in children with type 1 diabetes, Rewers [/bib_ref]. Glycemic control and diabetes outcomes are also poorer when patients do not understand or participate in their care.
The relative risk of death is higher for young adults with diabetes than for those without diabetes [bib_ref] The British Diabetic Association Cohort Study, I: all-cause mortality in patients with..., Laing [/bib_ref]. Lapses in care or loss to follow-up accounts for some of these adverse outcomes of transitioning older teens and young adults [bib_ref] Problems in transition from pediatric care to adult care for individuals with..., Pacaud [/bib_ref] [bib_ref] Evaluation of patients' opinion and metabolic control after transfer of young adults..., Busse [/bib_ref] [bib_ref] Glycaemic control and diabetes care utilization in young adults with Type 1..., Sparud-Lundin [/bib_ref]. Older teens and young adults with diabetes, especially those from racial/ethnic minority or low socioeconomic status backgrounds, require increased access to care in order to maintain continuity and coordination of multidisciplinary support and to receive ongoing self-management support. Continuous follow-up helps reduce the need for costly, acute hospitalizations and provides for early intervention of chronic complications to optimize longterm health outcomes and functioning.
Increased risk for acute complications A variety of factors may increase the risk of hypoglycemia and severe hyperglycemia or DKA in transitioning youth, including loss of parental supervision of diabetes care and reduced attendance at diabetes medical visits. The challenges of work and/or school often take precedence over diabetes care. Other lifestyle changes may include increases in alcohol consumption, changes in physical activity levels, varying motivation for self-care (as emerging young adults separate from parents), and differing dietary patterns from a more controlled family-home environment. Although data are lacking on the incidence of severe hypoglycemia and DKA during the early transition years, in the Diabetes Control and Complications Trial (DCCT) adolescents aged 13-17 years at study entry and care.diabetesjournals.org DIABETES CARE, VOLUME 34, NOVEMBER 2011 2479 20-24 years at study's end had a higher rate of severe hypoglycemia than adults. Rates of DKA in older adolescents are associated with nonadherence and poorer glycemic control [bib_ref] Adherence to insulin treatment, glycaemic control, and ketoacidosis in insulin-dependent diabetes mellitus...., Morris [/bib_ref]. Recent studies of continuous glucose monitoring (CGM) have assessed rates of overnight hypoglycemia in individuals aged 15-24 years, with nocturnal hypoglycemia documented during 8.8% of nights. Real-time CGM and sensoraugmented pumps have the potential to reduce the incidence of hypoglycemic events while improving A1C in those with type 1 diabetes, although poor adherence regarding consistent CGM usage during the adolescent and young adult years has been a major limiting factor [bib_ref] Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group. Continuous glucose monitoring..., Tamborlane [/bib_ref].

## Psychosocial issues
Psychosocial challenges are common during emerging adulthood, occur more often in those with diabetes compared with those without diabetes, and occur more commonly during emerging adulthood than during other stages of life. Living with diabetes often brings with it a broad range of diabetes-related distresses. Diabetes-specific stressors that occur frequently and interfere with effective selfcare include not having clear and concrete goals for diabetes care; feeling discouraged and overwhelmed with the diabetes regimen; uncomfortable interactions concerning diabetes with family, friends, or coworkers who do not have diabetes; feelings of guilt or anxiety about getting off track with diabetes self-care; and worrying about the future and the possibility of serious complications [bib_ref] Assessment of diabetes-related distress, Polonsky [/bib_ref]. Anxiety disorders, the most frequently diagnosed psychiatric disorder in the general population, can complicate living with and self-management of diabetes, for example when fear of injections triggers panic attacks, when symptoms of anxiety are confused with hypoglycemia, or when anxiety about hypoglycemia becomes unmanageable.
Depression or the presence of depressive symptoms is a well-known comorbid condition for individuals with diabetes. In addition to being a barrier to effective diabetes self-management, depression is linked to poor glycemic control (39) and diabetes complications [bib_ref] Association of depression and diabetes complications: a metaanalysis, De Groot [/bib_ref]. In adolescents with diabetes, including 18-to 20year-olds, 15-33% report depressive symptoms [bib_ref] SEARCH for Diabetes in Youth Study. Prevalence and correlates of depressed mood..., Lawrence [/bib_ref] [bib_ref] Depressive symptoms in children and adolescents with type 1 diabetes: association with..., Hood [/bib_ref] , while 23-35% of emerging adults (18-28 years of age) with diabetes do so [bib_ref] Prevalence and associations of psychological distress in young adults with Type 1..., Hislop [/bib_ref]. Recent data from the Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) study document similar levels of depressive symptoms in adolescents with type 2 diabetes, with rates of clinically significant depressive symptoms exceeding 20% in older adolescent females [bib_ref] Depressive symptoms and quality of life in adolescents with type 2 diabetes:..., Anderson [/bib_ref]. In addition, depressive symptoms were inversely associated with quality of life. Recognizing the trajectories of depressive symptoms to worsen and impact physical and psychosocial well-being as older teens transition into young adulthood, it is important to monitor and refer older adolescents and young adults with type 1 or type 2 diabetes to appropriate mental health resources.
Adolescent and postadolescent young women with diabetes have 2.4 times the risk of developing an eating disorder than age-matched women without diabetes [bib_ref] Eating disorders in adolescent females with and without type 1 diabetes: cross..., Jones [/bib_ref]. Although disordered eating behaviors occur in both sexes, they are much more common in women than men. About 30% of all women taking insulin struggle with subclinical symptoms of disordered eating, such as restrictive eating, a preoccupation with weight and shape, feelings of guilt after eating, and strategic misuse of insulin for weight control [bib_ref] Insulin omission in women with IDDM, Polonsky [/bib_ref]. Up to 60% are trying to lose weight with unhealthy weight control behaviors (47), with some studies showing as many as 57% of adolescents and young adults involved in the particularly unhealthy weight control behavior of intentional insulin mismanagement [bib_ref] Disordered eating behavior and microvascular complications in young women with insulindependent diabetes..., Rydall [/bib_ref] [bib_ref] Eating habits, body weight, and insulin misuse. A longitudinal study of teenagers..., Bryden [/bib_ref] [bib_ref] The relationship of disordered eating habits and attitudes to clinical outcomes in..., Peveler [/bib_ref]. One survey of 11,855 Minnesota students attending 2-year and 4-year colleges or universities revealed that about twice as many students with type 1 diabetes had been diagnosed with anorexia or bulimia compared with students without type 1 diabetes (overall survey results at http:// www.bhs.umn.edu/surveys/index.htm; data on type 1 diabetes not displayed).
Clinically diagnosable eating disorders such as anorexia and bulimia as well as subclinical disordered eating attitudes and behaviors present a serious health risk to the emerging adult with diabetes. Disordered eating is associated with poor metabolic control, reduced adherence, depression, increased risk of DKA, and increased rates of microvascular complications in women with diabetes [bib_ref] Diabetes Control and Complications Trial/ Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC)..., Nathan [/bib_ref]. Severe eating disorders, especially anorexia nervosa and purging through insulin omission, are life threatening, and such patients may require hospitalization on an inpatient eating disorders unit experienced in taking care of patients with type 1 diabetes. Disordered eating is not exclusive to youth with type 1 diabetes; 6% of a large cohort of adolescents with type 2 diabetes had clinical and 20% had subclinical levels of binge eating behaviors associated with more extreme obesity, global eating disorders, depressive symptoms, and poorer quality of life [bib_ref] TODAY Study Group. Binge eating, mood, and quality of life in youth..., Wilfley [/bib_ref].
In summary, eating disorders and affective disorders are especially serious in emerging adults who have diabetes because insulin omission, depression, anxiety, and fear of hypoglycemia interfere with diabetes self-care behavior during a time when these patients may have fallen between the cracks of the pediatric and adult health care systems. Moreover, longitudinal cohort studies have revealed that there is a subgroup of adolescents with serious mental health and behavior problems who continue to deteriorate as they enter their 20s, often with onset of microvascular complications and early mortality. Clinicians who care for emerging adults with type 1 diabetes need to evaluate the mental as well as the physical health history of their new patients and foster access to mental health providers for consultation and collaborative care for the diagnosis and treatment of eating disorders, depression, anxiety, and fear of hypoglycemia. The same principles hold for individuals with type 2 diabetes, although there are fewer published reports. Because the TODAY study is a longitudinal study of adolescents with type 2 diabetes, this investigation will provide important data on the onset, progression, and possible resolution of disordered eating behaviors and depression as these patients enter emerging adulthood [bib_ref] TODAY Study Group. Binge eating, mood, and quality of life in youth..., Wilfley [/bib_ref].

## Sexual and reproductive health issues
There is no reason to expect that emerging adults with diabetes will behave differently than their peers with respect to the potential for unintended pregnancies and acquisition of sexually transmitted infections. Thus, sexual behavior and reproductive health are important areas for discussion by both pediatric and adult care providers, even when the many medical issues related to diabetes and its complications tend to take precedence, delegating these issues to a secondary status.
Contraception needs to be addressed with adolescents and young women with diabetesdeven more so than in women without diabetesdbecause of the need for reproductive planning in order to avoid unplanned pregnancies and maximize the outcomes of diabetic pregnancies. Contraceptive use to prevent pregnancy is lower among adults with diabetes aged 20-44 years; 39% of those with diabetes were not current users of contraception compared with 27% of adults without diabetes [bib_ref] Family-planning practices among women with diabetes and overweight and obese women in..., Vahratian [/bib_ref]. Among teens aged 13-19 years with diabetes, only 16% reported using birth control and, among those ever sexually active, 67% had ever used birth control [bib_ref] Perceived access to contraception among adolescents with diabetes: barriers to preventing pregnancy..., Schwarz [/bib_ref]. An increasing number of young women with preexisting diabetes are becoming pregnant and delivering babies [bib_ref] Trends in the prevalence of preexisting diabetes and gestational diabetes mellitus among..., Lawrence [/bib_ref]. Given that the highest pregnancy and birth rates occur in the 18-to 30-year-old age range, the importance of preconception counseling and care for individuals with type 1 and type 2 diabetes is clear. Fewer than one in four young women aged 16-20 years with diabetes were aware of maternal and fetal risks of pregnancy and of the need for good glycemic control in order to conceive and give birth to a healthy child [bib_ref] Reproductive health and preconception counseling awareness in adolescents with diabetes: what they..., Charron-Prochownik [/bib_ref]. Although preconception care is often not a routine part of ongoing diabetes care, the development of a reproductive health plan as suggested by the Centers for Disease Control and Prevention Select Panel on Preconception Care is essential (http://www.cdc.gov/mmwr/preview/ mmwrhtml/rr5506a1.htm).
Alcohol, smoking, and drug abuse Emerging adults with diabetes may risk their health by involvement in behaviors such as drinking alcohol and smoking cigarettes. Among samples of adolescents and emerging adults with diabetes, alcohol and tobacco use seem equivalent to rates in those without diabetes. Alcohol use worsens glycemic control [bib_ref] Alcohol and drug use in teenagers with diabetes mellitus, Glasgow [/bib_ref] and is a known risk factor for severe hypoglycemia, while cigarette smoking increases cardiovascular risk and risk for microalbuminuria among adolescents and emerging adults with diabetes [bib_ref] Prevalence of tobacco use and association between cardiometabolic risk factors and cigarette..., Reynolds [/bib_ref] [bib_ref] A nonlinear effect of hyperglycemia and current cigarette smoking are major determinants..., Scott [/bib_ref]. Involvement in these and other high-risk behaviors such as drug abuse places these youth at risk for immediate and long-term diabetes complications. In addition, such high-risk behaviors impinge upon the safety of the older adolescent and young adult who is beginning to drive. Risks of these behaviors as well as the risks associated with hypoglycemia while driving should be discussed. Abstinence from alcohol and substance use while driving should be directly discussed, and appropriate blood glucose monitoring along with prevention and treatment of hypoglycemia before and during driving should be established.

## Emergence of signs of chronic diabetes complications
Rates of clinically apparent diabetes complications are low in adolescents, although there is evidence of early microvascular complications. About 10% of adolescents with type 1 diabetes have microalbuminuria (59), whereas ;30% of teens with type 2 diabetes have microalbuminuria [bib_ref] TODAY Study Group. Characteristics of adolescents and youth with recent-onset type 2..., Copeland [/bib_ref] ; the SEARCH study has verified a threefold higher rate of microalbuminuria in youth with type 2 compared with those with type 1 diabetes [bib_ref] Higher prevalence of elevated albumin excretion in youth with type 2 than..., Maahs [/bib_ref]. Higher rates of microalbuminuria and hypertension are seen in youth with type 2 than youth with type 1 diabetes, despite the fact that those with type 2 diabetes on average have shorter duration of disease [bib_ref] Prevalence of diabetes complications in adolescents with type 2 compared with type..., Eppens [/bib_ref]. Retinopathy is rare among teens with type 1 diabetes, although more common than among teens with type 2 diabetes (61); data are forthcoming from the TODAY study regarding the rates of retinopathy among teens and young adults with type 2 diabetes to supplement the modest data currently available. When neuropathy testing is performed, ;20% of adolescents with diabetes have evidence of peripheral sensory polyneuropathy and/or findings of autonomic neuropathy [bib_ref] Prevalence of diabetes complications in adolescents with type 2 compared with type..., Eppens [/bib_ref].
The beginnings of atherosclerotic disease occur in children and adolescents [bib_ref] The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Associations of..., Mcgill [/bib_ref]. Risk factors such as elevated LDL cholesterol level, reduced HDL cholesterol level, smoking, and higher A1C levels were associated with fatty streaks and raised intimal lesions in autopsy studies. Predictors of abnormal vessels in the Bogalusa Heart Study included high BMI, high total and LDL cholesterol, elevated triglycerides, and high systolic and diastolic blood pressure [bib_ref] Childhood cardiovascular risk factors and carotid vascular changes in adulthood: the Bogalusa..., Li [/bib_ref]. Therefore, risk factors similar to those identified in older individuals impact the development of atherosclerosis in adolescents and young adults. The presence of diabetes is associated with elevated carotid artery intima-media thickness, stiffer blood vessels independent of lipids, and higher levels of inflammatory markers compared with nondiabetic individuals [bib_ref] Carotid artery intima-media thickness in children with type 1 diabetes, Jarvisalo [/bib_ref] [bib_ref] Radial artery tonometry demonstrates arterial stiffness in children with type 1 diabetes, Haller [/bib_ref].
Although pediatricians treat diabetes complications infrequently, adult physicians follow guidelines that are specifically written to address the complications of diabetes. Adult guidelines are often based on data from older adults, usually with type 2 diabetes; therefore, their application to younger individuals with type 1 diabetes needs to be individualized. Nonetheless, discussion of diabetesrelated complications and preparation of the transitioning older teen or young adult for changes in care practices should occur prior to transition.

## Approaches to improve transitions in care
Previously published approaches on transitioning older teens and emerging adults with diabetes Teens and young adults require assistance with transition because they are a vulnerable population at risk for loss-to-followup care and poor health outcomes. Once transferred out of pediatric care, published reports provide evidence of gaps in follow-up care with a decrease in physician visits after transfer [bib_ref] Evaluation of patients' opinion and metabolic control after transfer of young adults..., Busse [/bib_ref] [bib_ref] Glycaemic control and diabetes care utilization in young adults with Type 1..., Sparud-Lundin [/bib_ref] [bib_ref] Exploring a black hole: Transition from paediatric to adult care services for..., Pacaud [/bib_ref]. Patients with fragmented follow-up care demonstrated poorer glycemic control and a higher rate of hospitalization [bib_ref] Transition to adult care for youths with diabetes mellitus: findings from a..., Nakhla [/bib_ref]. Therefore, the goal of transition programs is to focus on easing the transfer process from pediatric to adult care providers.
There is substantial interest in identifying effective ways to transition older teens and young adults with diabetes to adult care providers. Much of the published literature on the topic describes observational studies or uncontrolled programs, and there are no published, empirically tested, randomized controlled trials of validated transition programs. Studies using patient interviews, questionnaire responses, or focus group discussions indicate that young adults describe time as a major challenge to maintaining contact with the diabetes health care team following transfer. Some reports have suggested evening hours or flexible clinics. Others have suggested a longer visit as the initial meeting with the adult provider, the provision of special clinic times that focus exclusively on teens to young adults up to age 30 years, and the need to provide the transitioning patient with written information regarding the transfer process and the new physician. This information is in addition to the medical summary of the patient's past diabetes health care that should be provided to the receiving physician. Most of these studies have substantial limitations because they reflect small sample sizes and particular health care delivery systems [bib_ref] Evaluation of patients' opinion and metabolic control after transfer of young adults..., Busse [/bib_ref] [bib_ref] Exploring a black hole: Transition from paediatric to adult care services for..., Pacaud [/bib_ref] [bib_ref] The transition to young adulthood in youth with type 1 diabetes on..., Insabella [/bib_ref] [bib_ref] Evaluation of a systems navigator model for transition from pediatric to adult..., Van Walleghem [/bib_ref]. A recently published systematic review of the transition between pediatric and adult care identified only 10 studies across a spectrum of chronic diseases of childhood that evaluated particular care.diabetesjournals.org DIABETES CARE, VOLUME 34, NOVEMBER 2011 2481 interventions and associated outcomes [bib_ref] Improving the transition between paediatric and adult healthcare: a systematic review, Crowley [/bib_ref]. Of these studies, eight included patients with diabetes, one included patients with cystic fibrosis, and one included organ transplant recipients. The interventions targeted either the patient through education and skills training, staff through identification of coordinators or combined pediatric and adult team members, or delivered services through the creation of separate young adult clinics or enhanced after-hours phone support. While six of the studies reported improvements in either glycemic control, the occurrence of complications, or rates of follow-up visits and screening procedures, study methodologies varied, with only two studies using a controlled, comparison group design. Indeed, recent recommendations for the transition from pediatric to adult care for patients with cystic fibrosis focus on the preparation of the pediatric care providers, the training and availability of adult care providers versed in cystic fibrosis management, and assessment of transition readiness of pediatric patients and families rather than on empiric studies [bib_ref] Cystic fibrosis and transition to adult medical care, Tuchman [/bib_ref].

## Models of transition care
There are a few published reports of transition care models that have been established in the U.K., Spain, Australia, and Canada. The U.K. model evaluated different systems varying from transfer to an adult clinic or different hospital, transition to a combination of pediatric and adult care providers, or transfer to a young adult clinic within the same pediatric hospital [bib_ref] Glycaemic control and diabetes care utilization in young adults with Type 1..., Sparud-Lundin [/bib_ref]. The latter two approaches were associated with greater attendance at follow-up visits than the former. Other programs have included transition coordinators, sometimes referred to as patient navigators or care ambassadors, and other approaches that focused on transition education programs. The education programs included workshops aimed at preparing the transitioning teen. Some programs included monthly visits for the first 3-6 months in efforts to reduce loss to follow-up, while others used the transition coordinator to schedule and reschedule any missed appointments [bib_ref] Problems in transition from pediatric care to adult care for individuals with..., Pacaud [/bib_ref] [bib_ref] Evaluation of a systems navigator model for transition from pediatric to adult..., Van Walleghem [/bib_ref]. Future efforts need to standardize and empirically evaluate these various approaches with attention to assessing medical as well as psychosocial outcomes of care [bib_ref] Translating transition: a critical review of the diabetes literature, Nakhla [/bib_ref]. Additionally, there are settings, such as in family practice, where care can continue uninterrupted throughout the transitioning period.
Although there are a few observational studies addressing transitioning youth with type 1 diabetes [bib_ref] Evaluation of a systems navigator model for transition from pediatric to adult..., Van Walleghem [/bib_ref] [bib_ref] A transition care programme which improves diabetes control and reduces hospital admission..., Holmes-Walker [/bib_ref] , there are essentially no studies on transitioning individuals with type 2 diabetes. Given that the number of youth with type 2 diabetes is increasing, this is an important area of study.
Programs need to be designed and evaluated that identify a transition coordinator (i.e., care ambassador or patient navigator) who reaches out to the transitioning emerging adult using multiple means (phone, mail, e-mail, text messaging, social media, etc.) to ensure timely follow-up visits. Another model that needs to be designed and evaluated for older transitioning adolescents is a special clinic in which both pediatric and adult providers are in attendance.
OTHER ORGANIZATIONS' RECOMMENDATIONS FOR TRANSITION OF EMERGING ADULTS WITH DIABETESdMany professional organizations have identified the need to provide guidelines to ease the transition from pediatric to adult care, though not specifically for youth with diabetes [bib_ref] Diabetes in adolescence, Court [/bib_ref]. In 2002, the American Academy of Pediatrics, the American Academy of Family Physicians, and the American College of Physicians-American Society of Internal Medicine (75) released a policy statement that noted the goal of an effective transition plan is to provide developmentally appropriate health care services that continue uninterrupted as the individual moves from adolescence to adulthood. Similarly, in 2003, the Society for Adolescent Health and Medicine (76) published a position statement identifying the importance of organized and coordinated transition programs. These position statements along with a recent statement from the American Academy of Pediatrics (77) provide guidelines for the design and implementation of successful transition programs based upon published studies and expert opinion. Similarly, our committee created recommendations based upon published studies, models of transition across pediatric chronic diseases such as cystic fibrosis, published guidelines regarding the current recommendations for diabetes care for pediatric and adult patients, and expert opinion.

## Ada recommendations

## Summary and
IMPLICATIONSdFor emerging young adults with diabetes, it is particularly important to create effective and translatable processes for the transition in care from pediatric to adult providers in order to optimize well-being and health for the near term. It is additionally imperative for these young adults to achieve target glycemic control in order to prevent long-term complications and to maximize lifelong functioning. There are no proven strategies to achieve these goals, although programs that particularly target the young adult with diabetes through education, skills training, specialty transition clinics, or addition of transition coordinators appear to offer promise. Our current knowledge regarding this transition process calls for ongoing and expanding research initiatives, including the continued training and identification of adult providers versed not only in the medical care but also in the psychosocial needs of the young adult with diabetes. The next decade should see the emergence of evidence-based strategies that support best practice for the growing numbers of young adults with type 1 and type 2 diabetes who will be making this important transition.