Management of neck metastases in head and neck cancer: United Kingdom National Multidisciplinary Guidelines

This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. A rational plan to manage the neck is necessary for all head and neck primaries. With the emergence of new level 1 evidence across several domains of neck metastases, this guideline will identify the evidence-based recommendations for management.Recommendations- Computed tomographic or magnetic resonance imaging is mandatory for staging neck disease, with choice of modality dependant on imaging modality used for the primary site, local availability and expertise. (R) - Patients with a clinically N0 neck, with more than 15-20 per cent risk of occult nodal metastases, should be offered prophylactic treatment of the neck. (R) - The treatment choice of for the N0 and N+ neck should be guided by the treatment to the primary site. (G) - If observation is planned for the N0 neck, this should be supplemented by regular ultrasonograms to ensure early detection. (R) - All patients with T1 and T2 oral cavity cancer and N0 neck should receive prophylactic neck treatment. (R) - Selective neck dissection (SND) is as effective as modified radical neck dissection for controlling regional disease in N0 necks for all primary sites. (R) - SND alone is adequate treatment for pN1 neck disease without adverse histological features. (R) - Post-operative radiation for adverse histologic features following SND confers control rates comparable with more extensive procedures. (R) - Adjuvant radiation following surgery for patients with adverse histological features improves regional control rates. (R) - Post-operative chemoradiation improves regional control in patients with extracapsular spread and/or microscopically involved surgical margins. (R) - Following chemoradiation therapy, complete responders who do not show evidence of active disease on co-registered positron emission tomography-computed tomography (PET-CT) scans performed at 10-12 weeks, do not need salvage neck dissection. (R) - Salvage surgery should be considered for those with incomplete or equivocal response of nodal disease on PET-CT. (R) of disease. Controversy surrounds the management of the neck in head and neck squamous cell cancer. This is primarily due to the paucity of high-level evidence for many treatment paradigms, but this trend may be reversing with randomised controlled trials and systematic reviews published recently and a few

# Introduction
The presence, site and size of metastatic neck disease are important prognostic factors in head and neck squamous cell cancer. Head and neck tumours have a propensity to metastasise to neck nodes and several factors control the natural history and spread more in progress. This section discusses the management of neck metastases at initial presentation and for residual or recurrent neck disease. It outlines major clinical controversies regarding the management of occult and overt metastatic squamous cell carcinoma (SCC) to the neck nodes.

## Assessment and staging
For the purpose of assessment and documentation, the neck is described in six anatomical levels, . Level VII is relevant for some head and neck tumours and is included in the table for completeness.

## Clinical palpation
Clinical palpation is regarded as inaccurate (sensitivity and specificity 70-80 per cent) due to factors including inter-operator variability, shape of neck, absence or presence of significant subcutaneous fat and varying size of involved cervical nodes.
Computed tomographic (CT) and magnetic resonance imaging (MRI) scanning These techniques have similar sensitivity (81 per cent) in detecting metastatic disease, with CT demonstrating better specificity. [bib_ref] Detection of lymph node metastases in head and neck cancer: a meta-analysis..., De Bondt [/bib_ref] Co-registered positron emission tomography-computed tomography scanning (PET-CT) has been shown to alter initial staging in up to one-third of patients, but the value of this is unclear. This technique has higher sensitivity in picking up clinically occult primaries, synchronous second primaries and distant metastases. PET-CT has demonstrated high negative predictive values in the assessment of neck disease after organ preservation regimes.

## Ultrasound (us) scanning and us-guided fine needle aspiration cytology (fnac)
Ultrasound has been demonstrated to have consistently high sensitivity (87 per cent) in diagnosing metastatic neck disease. Ultrasound-guided FNAC requires both expertise and experience, and has very high specificity rates (98 per cent) in diagnosis. It should be noted that there are no absolute ultrasound characteristics for differentiating benign from malignant disease.

## Sentinel node biopsy
The aim of this technique is to identify and excise the echelon nodes using radioscintigraphy, which are then tested for occult disease. Patients with no occult disease in the sentinel nodes receive no further treatment for the neck. Meta-analyses suggest that sentinel node biopsy has sensitivity rates exceeding 90 per cent. 2,3 A recent prospective multicentre study that recruited 415 patients with 0.5-4 cm transorally resectable SCC and an N0 neck, showed that sentinel node biopsy had a sensitivity, negative predictive value and false negative rate of 86, 95 and 14 per cent, respectively. [bib_ref] Sentinel European Node Trial (SENT): 3-year results of sentinel node biopsy in..., Schilling [/bib_ref] [fig_ref] TABLE III CLASSIFICATION: OF NECK DISSECTION TECHNIQUES [/fig_ref]. There is an increasing trend to divide neck dissections into two broad types with subdivisions: comprehensive (removal of levels I-V) and selective (less than five levels). The need for less extensive surgery in the chemoradiation era, with neck dissection procedures that cannot be classified under the existing systems has led to calls for revision of this system. [bib_ref] Proposal for a rational classification of neck dissections, Ferlito [/bib_ref] It is recommended that the levels or sublevels removed during selective neck dissection (SND) be precisely stated in the operation notes. In order to minimise confusion within labelling the levels during processing, the neck dissection specimen should be divided according to the levels in the operating room and sent to the laboratory in different containers. An alternative is to orientate the neck dissection specimen on a suitable base and label the levels with a marking pen, with or without a photograph, and send it to the laboratory. There is good evidence for reduced longterm morbidity with SND compared with the comprehensive types, namely modified radical neck dissection (MRND) and radical neck dissection (RND). Surgical therapy must be delivered within accredited multidisciplinary teams, by members regularly involved in caring for head and neck cancer patients.

## Radiotherapy
Radiotherapy (RT) should be delivered within an accredited department using megavoltage photons typically from a linear accelerator (typical energy 6 MV). Similar principles should be used for selecting the nodes for RT as are described above for surgery. The probability of microscopic involvement of other nodal groups rises with increasing T-stage and this leads to larger volumes of tissue-requiring irradiation.
Radiotherapy to the neck requires adequate immobilisation and a five-point fixation shell is recommended. Computed tomography scanning in the treatment position provides the anatomical and electron density information required for RT planning. Conventional and three-dimensional conformal RT often require the use of multiple phases of treatment using photons and electrons of appropriate energy. These techniques have now been superseded by intensity modulated radiotherapy (IMRT), particularly where bilateral nodal irradiation is indicated, where it has been shown to be associated with a reduced risk of late xerostomia and has become the standard of care.
There is now increasing use of concomitant chemoradiotherapy following publication of level 1 studies, suggesting that use of chemoradiotherapy improves overall and progression free survival in advanced head and neck cancer both in the primary and post-operative settings. Altered fractionation regimes have also been shown to offer some advantage over standard fractionation.

## Management strategies for the various neck nodal stages
Treatment of cervical lymph nodes is either elective (in the clinically negative neck) or therapeutic (in the clinically positive neck).
Management of the clinically node negative neck (N0) New primary. Clinical and radiological examinations are unable to detect microscopic disease in lymph nodes. Several large retrospective series have reported the incidence of metastases found on histological examination after RNDs in patients with clinically node negative (N0) necks. These figures are useful in identifying the risk of occult metastases in N0 necks and are used to guide clinicians when deciding whether prophylactic treatment of the neck is appropriate .
A study of risk-benefit analysis made in the 1990s using data from retrospective series, when RND was the only procedure widely used for elective neck treatment, suggested that prophylactic treatment of the neck was required if the risk of occult nodal metastases rose above 20 per cent. Given the low morbidity of either available treatment modality, there is support for elective treatment for lesser risk (5-15 per cent). Primary sites with greater than 15 per cent risk of occult metastatic disease in the neck would include almost all squamous cancers of the upper aerodigestive tract except T1 and T2 cancers of the glottis and selected T1 cancers of the oral cavity.
A recent randomised controlled trial (RCT) reported on 500 patients with lateralised stage T1 or T2 oral SCCs randomised to elective neck dissection (n = 245) or observation and intervention (n = 255), with a median follow up period of 39 months. [bib_ref] Elective versus therapeutic neck dissection in nodenegative oral cancer, D&apos;cruz [/bib_ref] At three years, elective node dissection resulted in an improved rate of overall survival (80.0 per cent; 95 per cent confidence interval (CI), 74.1 to 85.8), as compared with therapeutic dissection (67.5 per cent; 95 per cent CI, 61.0 to 73.9), with a hazard ratio for death of 0.64 in the elective-surgery group (95 per cent CI, 0.45 to 0.92; p = 0.01 by the log-rank test). Patients in the elective-surgery group also had a higher rate of disease-free survival than those in the therapeutic-surgery group (69.5 per cent vs 45.9 per TABLE II TUMOUR-NODE-METASTASIS CLASSIFICATION OF REGIONAL NODES N x Regional lymph nodes cannot be assessed N 0 No regional lymph node metastases N 1 Metastasis in a single ipsilateral lymph node 3 cm or less in greatest dimension N 2 Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes none more than 6 cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension N 2a Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension N 2b Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension N 2c Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension N 3 Metastasis in a lymph node more than 6 cm in greatest dimension Note: Midline nodes are considered to be ipsilateral nodes

## S164
cent, p < 0.001). A meta-analysis of all previously published RCTs including data on 283 patients showed that elective neck dissection reduced the risk of disease-specific death (fixed-effects model relative risk = 0.57, 95 per cent CI 0.36-0.89, p = 0.014; random-effects model relative risk = 0.59, 95 per cent CI 0.37-0.96, p = 0.034) compared with observation. [bib_ref] A meta-analysis of the randomized controlled trials on elective neck dissection versus..., Fasunla [/bib_ref] The classical RND has no role to play in elective treatment of the N0 neck. [bib_ref] Management of metastatic neck disease -summary of the 11th Evidence Based Management..., O&apos;hara [/bib_ref] The choice lies between an MRND and an SND. Prospective studies suggest SND is as effective as MRND for most primary sites with minimal morbidity. [fig_ref] TABLE IV RECOMMENDED: NECK LEVELS TO BE DISSECTED FOR OCCULT NECK DISEASE BASED ON PRIMARY... [/fig_ref] shows the suggested neck levels that should be addressed for various primary sites, with the recommendations based on a recent analysis of the evidence base. [bib_ref] Management of metastatic neck disease -summary of the 11th Evidence Based Management..., O&apos;hara [/bib_ref] For oral cavity tumours, SND of levels I to III should be performed. Due to the possibility of skip lesions in level IV, especially in tongue tumours, some studies recommend including level IV. In oropharyngeal, laryngeal and hypopharyngeal tumours, SND of levels II-IV should be performed. Level IIb dissection may not be necessary for the majority of patients, as the incidence of isolated metastasis at this site is less than 2 per cent. [bib_ref] Dissection of the submuscular recess (sublevel IIb) in squamous cell cancer of..., Paleri [/bib_ref] Elective neck irradiation is as effective as elective neck dissection in controlling subclinical regional disease, with control rates reported to be around 90 per cent. When the primary tumour is treated with RT, first echelon lymph nodes, which are at the greatest risk of harbouring occult disease, are usually included in the high dose or radical RT treatment volume. A large retrospective series comparing elective neck dissection and elective neck irradiation in patients with oral cavity, oropharyngeal and laryngeal cancer reported no statistically significant difference in local control at five years. In patients with hypopharyngeal cancers, local control was significantly better with RT compared with surgery. The consensus guidelines drawn up by experts from clinical research organizations within Europe, Asia, Australia/New Zealand and North America, published in 2014, should be followed for delineation of lymph nodal levels in the node negative neck. [bib_ref] Delineation of the neck node levels for head and neck tumors: a..., Gregoire [/bib_ref] Large retrospective series have reported on the risk of contralateral nodal involvement by each anatomic tumour subsite. As in ipsilateral N0 necks, the contralateral neck should be treated if the estimated risk of occult spread exceeds 15-20 per cent, as occurs with tumours encroaching or crossing the midline. Elective nodal irradiation may be preferred to surgery when both sides of the neck are to be treated.
In long-term follow-up of the untreated N0 neck, consideration should be given where available to ultrasound surveillance and ultrasound-guided aspiration cytology as a method of detecting and treating early disease before it becomes clinically palpable. [bib_ref] Prospective randomized study of selective neck dissection versus observation for N0 neck..., Yuen [/bib_ref] Recurrent primary cancer. Occult metastatic rates are low (5-10 per cent) in the setting of radiorecurrent cancer if the neck has been included in the radiation field. As neck dissection (ND) in the salvage setting is associated with more complications with no reported benefit, if access to the neck vessels is not needed for primary resection or reconstruction, routine elective neck dissection may not be needed during salvage surgery for locally recurrent primary cancers. Management of the clinically node positive neck When there is clinical or radiological evidence of disease in neck lymph nodes, active treatment is required. Level 1 studies exist to guide the treatment of metastatic neck disease in specific scenarios [fig_ref] FIG. 3: Algorithm for management of the N+ neck when chemoradiation is the primary... [/fig_ref]. The risk of occult metastases in other apparently uninvolved levels of the neck is high, and depending on the primary site, treatment of these nodes is also required. Level V is least likely to be involved, with between 3 and 7 per cent of patients undergoing RND having positive nodes at level V. The treatment choice of the N+ neck should be guided by the treatment to the primary site, and there is long-term data to support this premise. 13 N1 neck disease. Prospective data from large cancer databases suggest that single modality therapy is sufficient to deal with ipsilateral, single nodes of less than 3 cm in size. If surgery is the chosen modality, SND may be appropriate. As approximately 50 per cent of clinically N1 necks are upstaged after pathological assessment, many patients subsequently require post-operative radiation. Prospective studies have shown that in the absence of bulky disease (N1, N2b), appropriate SND in combination with

## Recommendations

## S166
postoperative RT result in neck control rates equivalent to those achieved by comprehensive neck dissection. [bib_ref] Management of metastatic neck disease -summary of the 11th Evidence Based Management..., O&apos;hara [/bib_ref] Complete response rates are much higher in patients with nodes of less than 3 cm in size and regional control rates following RT alone are best in patients with nodes less than 2 cm in size.
N2 and N3 neck disease. If the primary modality is surgery for this stage of neck disease, MRND and RND result in equivalent rates of disease control in the neck when performed in appropriately selected patients. [bib_ref] Management of metastatic neck disease -summary of the 11th Evidence Based Management..., O&apos;hara [/bib_ref] Retrospective and prospective studies suggest that adding irradiation post-operatively increases regional control, [bib_ref] Chemotherapy added to locoregional treatment for head and neck squamouscell carcinoma: three..., Pignon [/bib_ref] especially in the presence of adverse features such as extracapsular nodal spread, positive margins, pT3 or pT4 primary, pN2 or pN3 nodal disease, nodal disease in levels IV or V, perineural invasion and vascular invasion. Randomised controlled trials from the EORTC and RTOG have shown improved control with chemoradiotherapy in the post-operative setting, especially in the presence of extracapsular spread and/or microscopically involved surgical margins. [bib_ref] Defining risk levels in locally advanced head and neck cancers: a comparative..., Bernier [/bib_ref] Patients with two or more histopathologically involved lymph nodes without extracapsular spread as their only risk factor did not benefit from the addition of chemotherapy. Morbidity of neck irradiation is higher in patients who have undergone an RND.
If the primary site is suitable for non-surgical treatment, the neck should be treated at the same time. For neck disease staged N2 and above, this will usually involve chemoradiotherapy. The PET-Neck phase III randomised trial compared PET-CT-guided active surveillance with planned neck dissection for neck disease staged N2 or N3 treated by chemoradiotherapy. The study recruited 282 patients into each arm and showed that the survival outcomes were similar with a minimum follow up of two years. A post treatment PET-CT surveillance strategy led to fewer neck dissections, fewer complications, was cost effective (per person cost saving of 1415) and provided 0.07 additional quality adjusted life years compared with planned neck dissection. Based on the results of the PET-Neck trial, there is no role for planned neck dissection after primary chemoradiotherapy. [bib_ref] PET-NECK -a multi-centre randomized phase III controlled trial (RCT) comparing PETCT guided..., Mehanna [/bib_ref] The current standard of care should be a CT-PET scan between 10 and 12 weeks following chemoradiotherapy, with ND being offered to those who show incomplete or equivocal response of nodal disease. Complete responders may need no further intervention. [bib_ref] Diagnostic performance of post-treatment FDG PET or FDG PET/CT imaging in head..., Gupta [/bib_ref] The extent of the salvage neck dissection can be based on local protocols, with the recognition that there is an increasing trend to perform a limited neck clearance in these individuals, with removal of the involved level alone or an adjacent level. In patients with fixed and unresectable nodal disease, RT or chemoradiotherapy will be the only options available, but a low likelihood of curative outcome should be recognised.
If the primary tumour is small but sited where resection is not feasible, and associated with advanced neck disease, resection of the nodal disease followed by treatment of the primary tumour by RT ( chemotherapy) plus post-operative RT to the involved neck could potentially be considered but this will be associated with a significant delay in the management of the primary disease which may result in interval primary disease progression.

## Recommendations
- The treatment choice to the N+ neck should be guided by the treatment to the primary site (G) - Selective neck dissection alone is adequate treatment for pN1 neck disease without adverse histological features (R) - Post-operative radiation for adverse histologic features following SND confers control rates comparable to more extensive procedures (R) - Adjuvant radiation following surgery for patients with adverse histological features improves regional control rates (R) - Post-operative chemoradiation improves regional control in patients with extracapsular spread and/or microscopically involved surgical margins (R)
Assessing treatment response Neck node size and fixity predict response rate and local control with RT alone. In patients with clinical N2 or N3 disease, there is poor correlation between clinical and pathological response following chemoradiotherapy. As discussed above, the PET-Neck trial demonstrated equivalent survival rates to planned neck dissection, with a lower morbidity and a higher overall cost-effectiveness. Co-registered PET-CT scans, performed at least 10 weeks after treatment is now considered the standard of care. A negative PET-CT scan following treatment portends a high disease free survival. [bib_ref] Long-term results of positron emission tomography-directed management of the neck in node-positive..., Sjovall [/bib_ref] High standard uptake values are associated with residual disease and this can be used to decide the need for neck dissection following primary chemoradiotherapy. [bib_ref] Diagnostic performance of post-treatment FDG PET or FDG PET/CT imaging in head..., Gupta [/bib_ref] [bib_ref] Management of the neck after chemoradiotherapy for head and neck cancers in..., Wee [/bib_ref] [bib_ref] A systematic review and meta-analysis of the role of positron emission tomography..., Isles [/bib_ref] Recommendations - Following chemoradiation therapy, complete responders who do not show evidence of active disease on co-registered PET-CT scans performed at 10-12 weeks, do not need salvage neck dissection (R) - Salvage surgery should be considered for those with incomplete or equivocal response of nodal disease on PET-CT (R)

## Management of recurrent neck disease
Prior to planning salvage treatment, the patient should be meticulously evaluated for distant metastases. This group is likely to benefit from PET-CT scans to look for distant metastases. If the recurrence has occurred following RT or chemoradiotherapy and is surgically resectable, surgery should be offered but acknowledge the higher risk of complications. In patients who present with unresectable disease, re-irradiation with or without chemotherapy should be considered, particularly in those who present more than two years since their previous treatment. Evidence of partial repair of RTinduced spinal cord subclinical damage and newer RT delivery techniques (IMRT, Tomotherapy  , protons) that allow better sparing of neurological, vascular and soft tissue at risk make this a realistic option in a larger number of patients. In patients who recur after previous surgical treatment, options include re-resection followed by adjuvant radiation, or primary RT or chemoradiotherapy.

## Palliative care
Patients who have incurable nodal recurrence present a significant challenge, particularly when distant metastases are not present as people can then live with recurrent disease for many months or longer. Fungating neck nodes have a significant effect on psychosocial function. The impact on speech and swallowing needs careful discussion with dieticians and speech and language therapists so that the potential benefits of tube feeding can be weighed against the risk of over-medicalising terminal care. Specialist palliative care teams should ideally be involved in these discussions before such complications develop. There may be occasions where palliative RT, chemotherapy or surgery have the potential to improve quality of life (QoL) in this situation. The overall expected prognosis, patient perspective and goals, morbidity of treatment and likely benefits need to be openly discussed to ensure that there is a reasonable expectation that any intervention will improve QoL for a given individual.

## Ongoing research
Current portfolio studies open to recruitment and relevant to neck metastases include: the role of SND in patients with early oral SCC (1-3 cm primary size) and no clinical evidence of lymph node metastases in the neck (SEND trial).

## Key points
- The neck stage is the single most important tumour prognostic factor - Prognosis is affected by number of involved nodes, the anatomic level in the neck, tumour load, the presence of extracapsular spread, perineural and vascular invasion, previous treatment by surgery or radiotherapy and resectability
- A large number of malignant nodes will measure less than 10 mm in diameter and extracapsular spread will occur in a substantial percentage of smaller nodes, as small as 2 mm. These may not be identified on conventional (CT and magnetic resonance) imaging - Incidence of nodal metastases depends on site and size of the primary tumour. This figure may be as low as 1 per cent for early glottic tumours or as high as 80 per cent for nasopharyngeal carcinomas - The majority of tumours will metastasise in a predictable manner to certain nodal groups but it should be remembered that tumours can metastasise to more remote sites (i.e. nasopharyngeal cancers to level V, tongue cancers to level IV) and that the pattern of spread will be disrupted by previous surgery or radiotherapy - The possibility of bilateral nodal disease should be considered especially when the primary site involves the tongue base, nasopharynx or supraglottic larynx or when the primary site crosses midline - Neck dissections should be documented as per the accepted classification system - Radiotherapy target delineation should follow the internationally recognised consensus guidelines - Standardised reporting of neck dissection specimens according to the Royal College of Pathologists data set is essential - Issues of function and quality of life have to be considered in the management of metastatic neck disease.
[fig] S: Left anterior belly of digastric P (L): Right anterior belly of digastric Nodes above the level of lower body of hyoid bone, below mylohyoid muscles and anterior to a transverse line drawn through the posterior edge of submandibular gland on an axial image Ib ubmandibular triangle : Body of mandible I: Posterior belly of digastric A (M): Anterior belly of digastric P (L): tylohyoid muscle IIa Upper jugular : Lower level of bony margin of jugular fossa I: Level of lower body of hyoid bone A (M): tylohyoid muscle P (L): Vertical plane defined by accessory nerve uperior and inferior limits as described under surgical boundaries Nodes posterior to a transverse plane defined by the posterior surface of submandibular gland and anterior to a transverse line drawn along the posterior border of the sternomastoid. NOTE: Nodes lying medial to the carotids are retropharyngeal and not level II IIb Upper jugular : Lower level of bony margin of jugular fossa I: Level of lower body of hyoid bone A (M): Vertical plane defined by accessory nerve P (L): Posterior border of sternomastoid muscle III Mid Jugular : Level of lower body of hyoid bone I: Horizontal plane along inferior border of anterior cricoid arch A (M): Lateral border of sternohyoid muscle P (L): Posterior border of sternocleidomastoid muscle or sensory branches of the cervical plexus uperior and inferior limits as described under surgical boundaries Nodes anterior to a transverse line drawn on each axial scan through the posterior edge of the CM and lateral to the medial margin of the common carotid arteries IV Lower jugular : Horizontal plane along inferior border of anterior cricoid arch I: Clavicle A (M): Lateral border of sternohyoid muscle P (L): Posterior border of sternocleidomastoid muscle or sensory branches of the cervical plexus uperior and inferior limits as described under surgical boundaries Nodes anterior to a transverse line drawn on each axial scan through the posterior edge of the CM and lateral to the medial margin of the common carotid arteries Va Posterior triangle : Convergence of CM and trapezius muscles I: Horizontal plane along inferior border of anterior cricoid arch A (M): Posterior border of sternocleidomastoid muscle or sensory branches of the cervical plexus P (L): Anterior border of trapezius muscle Nodes posterior to a transverse line drawn on each axial scan through the posterior edge of the = superior; I = inferior, A = anterior; P = posterior, L = lateral; M = medial; CM = sternocleidomastoid NECK METATAE IN HEAD AND NECK CANCER: UK GUIDELINE 163 [/fig]
[fig] FIG. 3: Algorithm for management of the N+ neck when chemoradiation is the primary modality.FIG. 2 Algorithm for management of the N+ neck when surgery is the primary modality. V PALERI, T G URBANO, H MEHANNA et al. [/fig]
[table] TABLE IV RECOMMENDED: NECK LEVELS TO BE DISSECTED FOR OCCULT NECK DISEASE BASED ON PRIMARY SITE [/table]