Kruppel-like factor gene transcriptions
"Kruppel-like factor 1 (KLF1/EKLF) is a transcription factor that globally activates genes involved in erythroid cell development.  KLF1 belongs to the KLF family of transcription factors that binds the G-rich strand of so-called CACCC-box motifs located in regulatory regions of numerous erythroid genes."

# Human genes
The following human genes encode Kruppel-like factors: KLF1, KLF2, KLF3, KLF4, KLF5, KLF6, KLF7, KLF8, KLF9, KLF10, KLF11, KLF12, KLF13, KLF14, KLF15, KLF16, KLF17.

# Interactions

# Consensus sequences
"Using the in vitro CASTing method, we identified a new set of sequences bound by  CDA-KLF1, and based on them we defined the consensus binding site as 5-NGG-GG(T/G)-(T/G)(T/G)(T/G)-3. It differs from the consensus binding sites for  WT-KLF1, 5-NGG-G(C/T)G-(T/G)GG-3, and for  Nan-KLF1, 5-NGG-G(C/A)N-(T/G)GG-3, as well."
An apparent consensus is GGG(A/C/G/T)(A/C/G/T)(G/T)(G/T)(G/T).

# Kruppel-like factor Samplings
Copying an apparent consensus sequence for the KLF of GGGTCGTG and putting it in "F" finds six located between ZSCAN22 and A1BG and none between ZNF497 and A1BG as can be found by the computer programs.
For the Basic programs testing consensus sequence GGGNN(G/T)(G/T)(G/T) (starting with SuccessablesKRUP.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:
- negative strand, negative direction, looking for GGGNN(G/T)(G/T)(G/T), 15, GGGTCGGG at 4482, GGGTAGGT at 4457, GGGTCTTG at 4450, GGGTTGTG at 3981, GGGTATGG at 3858, GGGACTTG at 3783, GGGTCGTG at 3733, GGGTTGTT at 3139, GGGTCGTG at 3072, GGGTTGTG at 2549, GGGTCGTG at 1787, GGGCAGTT at 1512, GGGTCGTG at 1142, GGGTCGTG at 678, GGGTCGTG at 405.
- negative strand, positive direction, looking for GGGNN(G/T)(G/T)(G/T), 22, GGGGCGGG at 4440, GGGAGGGG at 4435, GGGGCGGG at 4430, GGGTCTGG at 4416, GGGAGGGG at 3981, GGGTGGGG at 3542, GGGCAGGG at 2297, GGGAGGGG at 2291, GGGGAGGG at 2290, GGGACTTT at 2273, GGGTGTGG at 1805, GGGACTGT at 916, GGGACTGT at 816, GGGGAGTG at 495, GGGCGTTG at 448, GGGCTGGG at 418, GGGGCTGG at 417, GGGACGGG at 412, GGGCCTGG at 286, GGGCTGTG at 265, GGGGCTGT at 264, GGGCATTG at 23.
- positive strand, negative direction, looking for GGGNN(G/T)(G/T)(G/T), 10, GGGCCTTG at 3570, GGGTGTGG at 3186, GGGCGTGG at 3047, GGGCTGGG at 3042, GGGGCTGG at 3041, GGGAGTTG at 2704, GGGCGTGG at 1897, GGGCGTGG at 1244, GGGCCGGG at 514, GGGAAGTT at 83.
- positive strand, positive direction, looking for GGGNN(G/T)(G/T)(G/T), 12, GGGTCTGT at 4332, GGGACGGG at 4233, GGGACTGG at 4216, GGGCCGTG at 4005, GGGAGTGT at 3505, GGGAGTGT at 3209, GGGCAGGG at 3204, GGGTCTTG at 3093, GGGTGGGG at 2019, GGGACTGG at 1662, GGGAAGGG at 1071, GGGTGGGT at 71.
- complement, negative strand, negative direction, looking for CCCNN(A/C)(A/C)(A/C), 10, CCCGGAAC at 3570, CCCACACC at 3186, CCCGCACC at 3047, CCCGACCC at 3042, CCCCGACC at 3041, CCCTCAAC at 2704, CCCGCACC at 1897, CCCGCACC at 1244, CCCGGCCC at 514, CCCTTCAA at 83.
- complement, negative strand, positive direction, looking for CCCNN(A/C)(A/C)(A/C), 12, CCCAGACA at 4332, CCCTGCCC at 4233, CCCTGACC at 4216, CCCGGCAC at 4005, CCCTCACA at 3505, CCCTCACA at 3209, CCCGTCCC at 3204, CCCAGAAC at 3093, CCCACCCC at 2019, CCCTGACC at 1662, CCCTTCCC at 1071, CCCACCCA at 71.
- complement, positive strand, negative direction, looking for CCCNN(A/C)(A/C)(A/C), 15, CCCAGCCC at 4482, CCCATCCA at 4457, CCCAGAAC at 4450, CCCAACAC at 3981, CCCATACC at 3858, CCCTGAAC at 3783, CCCAGCAC at 3733, CCCAACAA at 3139, CCCAGCAC at 3072, CCCAACAC at 2549, CCCAGCAC at 1787, CCCGTCAA at 1512, CCCAGCAC at 1142, CCCAGCAC at 678, CCCAGCAC at 405.
- complement, positive strand, positive direction, looking for CCCNN(A/C)(A/C)(A/C), 22, CCCCGCCC at 4440, CCCTCCCC at 4435, CCCCGCCC at 4430, CCCAGACC at 4416, CCCTCCCC at 3981, CCCACCCC at 3542, CCCGTCCC at 2297, CCCTCCCC at 2291, CCCCTCCC at 2290, CCCTGAAA at 2273, CCCACACC at 1805, CCCTGACA at 916, CCCTGACA at 816, CCCCTCAC at 495, CCCGCAAC at 448, CCCGACCC at 418, CCCCGACC at 417, CCCTGCCC at 412, CCCGGACC at 286, CCCGACAC at 265, CCCCGACA at 264, CCCGTAAC at 23.
- inverse complement, negative strand, negative direction, looking for (A/C)(A/C)(A/C)NNCCC, 8, CACTACCC at 3800, ACCAACCC at 3607, CACCACCC at 3193, CCCGACCC at 3042, CACCACCC at 1904, CACCGCCC at 1251, CCCGGCCC at 514, CAACTCCC at 88.
- inverse complement, negative strand, positive direction, looking for (A/C)(A/C)(A/C)NNCCC, 10, CACCGCCC at 4292, CCCTGCCC at 4233, ACCTCCCC at 3555, CCCGTCCC at 3204, CACCCCCC at 2021, CCACCCCC at 2020, CCCACCCC at 2019, ACCCACCC at 2018, ACAGTCCC at 1827, CCCTTCCC at 1071.
- inverse complement, positive strand, negative direction, looking for (A/C)(A/C)(A/C)NNCCC, 5, CCCAGCCC at 4482, AACTGCCC at 3853, AACAGCCC at 3728, AACAACCC at 2845, AAACCCCC at 2624.
- inverse complement, positive strand, positive direction, looking for (A/C)(A/C)(A/C)NNCCC, 30, CCCCGCCC at 4440, CCCTCCCC at 4435, CCCCGCCC at 4430, CCAGACCC at 4417, AACGACCC at 4178, CCCTCCCC at 3981, ACACTCCC at 3906, CACCACCC at 3817, CCCACCCC at 3542, CACGTCCC at 3467, CACAACCC at 2817, CCCGTCCC at 2297, CCCTCCCC at 2291, CCCCTCCC at 2290, AAACCCCC at 2286, AAAACCCC at 2285, AAAAACCC at 2284, ACAGACCC at 1865, CACGTCCC at 1789, CCACGCCC at 1765, AAAAGCCC at 1752, AACGCCCC at 1708, ACCGCCCC at 1027, CACCGCCC at 1026, AACGTCCC at 659, CACGCCCC at 491, CCACGCCC at 490, CCCGACCC at 418, CCCTGCCC at 412, ACCCGCCC at 407.
- inverse negative strand, negative direction, looking for (G/T)(G/T)(G/T)NNGGG, 5, GGGTCGGG at 4482, TTGACGGG at 3853, TTGTCGGG at 3728, TTGTTGGG at 2845, TTTGGGGG at 2624.
- inverse negative strand, positive direction, looking for (G/T)(G/T)(G/T)NNGGG, 30, GGGGCGGG at 4440, GGGAGGGG at 4435, GGGGCGGG at 4430, GGTCTGGG at 4417, TTGCTGGG at 4178, GGGAGGGG at 3981, TGTGAGGG at 3906, GTGGTGGG at 3817, GGGTGGGG at 3542, GTGCAGGG at 3467, GTGTTGGG at 2817, GGGCAGGG at 2297, GGGAGGGG at 2291, GGGGAGGG at 2290, TTTGGGGG at 2286, TTTTGGGG at 2285, TTTTTGGG at 2284, TGTCTGGG at 1865, GTGCAGGG at 1789, GGTGCGGG at 1765, TTTTCGGG at 1752, TTGCGGGG at 1708, TGGCGGGG at 1027, GTGGCGGG at 1026, TTGCAGGG at 659, GTGCGGGG at 491, GGTGCGGG at 490, GGGCTGGG at 418, GGGACGGG at 412, TGGGCGGG at 407.
- inverse positive strand, negative direction, looking for (G/T)(G/T)(G/T)NNGGG, 8, GTGATGGG at 3800, TGGTTGGG at 3607, GTGGTGGG at 3193, GGGCTGGG at 3042, GTGGTGGG at 1904, GTGGCGGG at 1251, GGGCCGGG at 514, GTTGAGGG at 88.
- inverse positive strand, positive direction, looking for (G/T)(G/T)(G/T)NNGGG, 10, GTGGCGGG at 4292, GGGACGGG at 4233, TGGAGGGG at 3555, GGGCAGGG at 3204, GTGGGGGG at 2021, GGTGGGGG at 2020, GGGTGGGG at 2019, TGGGTGGG at 2018, TGTCAGGG at 1827, GGGAAGGG at 1071.

## Krup UTR gene transcriptions
Negative strand, negative direction: GGGTCGGG at 4482, GGGTAGGT at 4457, GGGTCTTG at 4450, GGGTTGTG at 3981, GGGTATGG at 3858, CACTACCC at 3800, GGGACTTG at 3783, GGGTCGTG at 3733, ACCAACCC at 3607, CACCACCC at 3193, GGGTTGTT at 3139, GGGTCGTG at 3072, CCCGACCC at 3042.
Positive strand, negative direction: AACTGCCC at 3853, AACAGCCC at 3728, GGGCCTTG at 3570, GGGTGTGG at 3186, GGGCGTGG at 3047, GGGGCTGG at 3041.

## Krup core promoters
Positive strand, negative direction: AACAACCC at 2845.
Negative strand, positive direction: GGGGCGGG at 4440, GGGAGGGG at 4435, GGGGCGGG at 4430, GGGTCTGG at 4416, CACCGCCC at 4292.
Positive strand, positive direction: CCAGACCC at 4417, GGGTCTGT at 4332.

## Krup proximal promoters
Positive strand, negative direction: GGGAGTTG at 2704, AAACCCCC at 2624.
Negative strand, positive direction: CCCTGCCC at 4233.
Positive strand, positive direction: GGGACTGG at 4216, AACGACCC at 4178.

## Krup distal promoters

### Negative direction distals
Negative strand, negative direction: GGGTTGTG at 2549, CACCACCC at 1904, GGGTCGTG at 1787, GGGCAGTT at 1512, CACCGCCC at 1251, GGGTCGTG at 1142, GGGTCGTG at 678, CCCGGCCC at 514, GGGTCGTG at 405, CAACTCCC at 88.
Positive strand, negative direction: GGGCGTGG at 1897, GGGCGTGG at 1244, GGGCCGGG at 514, GGGAAGTT at 83.

### Positive direction distals
Negative strand, positive direction: GGGAGGGG at 3981, ACCTCCCC at 3555, GGGTGGGG at 3542, CCCGTCCC at 3204, GGGCAGGG at 2297, GGGAGGGG at 2291, GGGGAGGG at 2290, GGGACTTT at 2273, CACCCCCC at 2021, CCACCCCC at 2020, CCCACCCC at 2019, ACCCACCC at 2018, ACAGTCCC at 1827, GGGTGTGG at 1805, CCCTTCCC at 1071, GGGACTGT at 916, GGGACTGT at 816, GGGGAGTG at 495, GGGCGTTG at 448, GGGCTGGG at 418, GGGGCTGG at 417, GGGACGGG at 412, GGGCCTGG at 286, GGGCTGTG at 265, GGGGCTGT at 264, GGGCATTG at 23.
Positive strand, positive direction: GGGCCGTG at 4005, ACACTCCC at 3906, CACCACCC at 3817, GGGAGTGT at 3505, CACGTCCC at 3467, GGGAGTGT at 3209, GGGTCTTG at 3093, CACAACCC at 2817, AAACCCCC at 2286, AAAACCCC at 2285, AAAAACCC at 2284, ACAGACCC at 1865, CACGTCCC at 1789, CCACGCCC at 1765, AAAAGCCC at 1752, AACGCCCC at 1708, GGGACTGG at 1662, ACCGCCCC at 1027, CACCGCCC at 1026, AACGTCCC at 659, CACGCCCC at 491, CCACGCCC at 490, ACCCGCCC at 407, GGGTGGGT at 71.

# Response element random dataset samplings
- KRUPr0: 11, GGGCCGTT at 4471, GGGTGTTT at 3708, GGGTATTT at 3513, GGGTTGTG at 3019, GGGGTTGT at 3018, GGGCGGTG at 2998, GGGGCTGG at 2469, GGGGGGGG at 1650, GGGCTGGG at 827, GGGATGTG at 764, GGGTTGTG at 724.
- KRUPr1: 9, GGGCTGGG at 3918, GGGCAGGG at 2653, GGGCCTGT at 2389, GGGCGTTT at 1481, GGGAGGTG at 1172, GGGGAGGT at 1171, GGGCCTTG at 1117, GGGTAGTT at 559, GGGTTTTG at 280.
- KRUPr2: 19, GGGGGGTT at 4301, GGGGGGGT at 4300, GGGGGTGG at 4009, GGGACTTG at 3503, GGGCATTT at 3299, GGGTTTTT at 2824, GGGCGGGT at 2820, GGGGCGGG at 2819, GGGAGTGT at 2791, GGGGAGTG at 2790, GGGCCGTT at 2702, GGGGAGGT at 2611, GGGCCTTT at 2286, GGGGAGTG at 2160, GGGTTGGG at 1287, GGGGTTGG at 1286, GGGTATTT at 808, GGGAGTGT at 193, GGGAAGGG at 47.
- KRUPr3: 19, GGGTTGTT at 4514, GGGTGTTT at 4497, GGGATTTT at 3757, GGGGATTT at 3756, GGGGCTTT at 3638, GGGCAGGG at 3332, GGGCATTT at 2538, GGGAGTTG at 2263, GGGGAGTT at 2262, GGGTGTGG at 2011, GGGCCGGG at 1991, GGGGCTGG at 1925, GGGAGGGT at 1629, GGGGAGGG at 1628, GGGAGGGG at 1624, GGGATTGG at 1231, GGGACGTT at 630, GGGTTGTT at 530, GGGGCGGG at 519.
- KRUPr4: 15, GGGTCGGT at 4243, GGGCGTGG at 3733, GGGGCGTG at 3732, GGGATTTT at 2768, GGGGATTT at 2767, GGGTTGTT at 2436, GGGTTTTT at 2426, GGGACTGT at 2416, GGGTAGTT at 2397, GGGTATGG at 1830, GGGACGTT at 1606, GGGTTTTG at 1382, GGGCTTTT at 1345, GGGCCGGT at 355, GGGTAGGG at 33.
- KRUPr5: 23, GGGCAGGG at 3907, GGGTCGGG at 3178, GGGAGGGG at 2753, GGGCCGGG at 2691, GGGAGGTT at 2586, GGGGGTTT at 2497, GGGGGGTT at 2496, GGGAATGG at 2341, GGGTTTGT at 2040, GGGCGGGT at 2036, GGGGCGGG at 2035, GGGTTTGT at 1720, GGGTATTT at 1312, GGGTCTGG at 1045, GGGGCTGG at 773, GGGTTGGG at 741, GGGGTTGG at 740, GGGTCGGT at 464, GGGTTGGT at 255, GGGGTTGG at 254, GGGCTTTT at 219, GGGTTGGG at 43, GGGGTTGG at 42.
- KRUPr6: 15, GGGCGGTT at 4352, GGGGCGGT at 4351, GGGTATTG at 4108, GGGGTTTG at 3933, GGGCAGGT at 3799, GGGCATTT at 3747, GGGTGGGG at 3741, GGGCTTGT at 3575, GGGAATTT at 2798, GGGGGGTT at 2115, GGGACGGT at 1512, GGGAGGTT at 1270, GGGGAGGT at 1269, GGGAGTTG at 430, GGGGAGTT at 429.
- KRUPr7: 20, GGGTCTTT at 4233, GGGCTTGG at 3724, GGGAAGGG at 3712, GGGCTTTT at 3257, GGGTCTTT at 3093, GGGAGTTG at 2872, GGGTTGTG at 2139, GGGTTTGG at 1848, GGGCGTGG at 1790, GGGGCGTG at 1789, GGGAGGGG at 1783, GGGTTGTG at 1311, GGGAGGTG at 1260, GGGGAGGT at 1259, GGGCTGTG at 917, GGGGCTGT at 916, GGGCGTGG at 453, GGGTTTTT at 348, GGGTGGGG at 134, GGGATGTG at 118.
- KRUPr8: 18, GGGACGTT at 3602, GGGCAGGG at 3535, GGGGGGGG at 3462, GGGTATGT at 3443, GGGGCTTG at 3322, GGGTGTTG at 3302, GGGCTTGG at 2637, GGGAGTGG at 2586, GGGTTGTT at 2381, GGGAATTG at 1976, GGGTGTTG at 1596, GGGCAGGT at 1515, GGGCAGGT at 1021, GGGTAGGG at 576, GGGCGGGG at 243, GGGGCGGG at 242, GGGTGGGG at 100, GGGTTTGT at 42.
- KRUPr9: 8, GGGAATTG at 4202, GGGACGGT at 3280, GGGCTTGT at 3166, GGGTATTT at 2782, GGGATTTT at 2140, GGGCCTTT at 1266, GGGCCGTT at 820, GGGTGTTT at 232.
- KRUPr0ci: 13, AAACCCCC at 4301, AAAACCCC at 4300, ACCCCCCC at 3159, AACGACCC at 2629, ACCCCCCC at 1861, AACCCCCC at 1860, CAACCCCC at 1859, CCCGACCC at 1600, CCCAACCC at 1523, CCCTTCCC at 123, AAATTCCC at 118, CCCTCCCC at 29, ACCCTCCC at 28.
- KRUPr1ci: 15, CACCCCCC at 4510, CACCGCCC at 3759, ACCCACCC at 3732, ACCTCCCC at 3544, AACCTCCC at 3543, AAACGCCC at 2860, ACACGCCC at 2665, CCCGACCC at 2355, AACCACCC at 2322, CCCCACCC at 1922, ACAAACCC at 1897, AACGACCC at 1737, AAATGCCC at 1426, CCCGGCCC at 124, ACAGGCCC at 78.
- KRUPr2ci: 19, CACAACCC at 3840, AAATGCCC at 3832, CAAGACCC at 3311, CCACCCCC at 3215, ACCACCCC at 3214, AACCACCC at 3213, AACATCCC at 3180, CACATCCC at 2811, ACCCCCCC at 2722, CCAGCCCC at 2564, CACACCCC at 2425, CACTACCC at 2152, CACCCCCC at 2107, ACCCCCCC at 1622, CACCCCCC at 1621, CCCTCCCC at 959, CCCCTCCC at 958, ACAGCCCC at 952, AACAGCCC at 951.
- KRUPr3ci: 23, CAACGCCC at 4280, CCCGTCCC at 4037, CCCCTCCC at 3831, ACCAGCCC at 3793, CCAGTCCC at 3571, CACCGCCC at 3080, CAATCCCC at 2495, ACAATCCC at 2494, ACCCCCCC at 2425, AACCCCCC at 2424, AAACCCCC at 2423, AAAACCCC at 2422, CAAAACCC at 2421, CCCTTCCC at 1862, AACTACCC at 1856, CACCTCCC at 1725, CCATTCCC at 1462, CCCAGCCC at 1427, CACCGCCC at 440, AAAGCCCC at 108, CAAAGCCC at 107, CCAGCCCC at 52, CCCAGCCC at 51.
- KRUPr4ci: 21, ACCTTCCC at 4195, ACATTCCC at 3701, AACCTCCC at 3640, CCAAGCCC at 3272, CAACCCCC at 3155, ACAACCCC at 2858, AAATACCC at 1781, ACCAGCCC at 1713, CCCCTCCC at 1523, AACACCCC at 1478, CACCACCC at 1150, ACACTCCC at 1056, CCCTACCC at 1037, CCCAGCCC at 1011, CACCCCCC at 917, CAAGTCCC at 632, CAAACCCC at 233, CCAAACCC at 232, CCACCCCC at 101, CCCACCCC at 100, AAACGCCC at 95.
- KRUPr5ci: 30, AACCCCCC at 4493, CAACCCCC at 4492, CCCAGCCC at 4365, CCCTCCCC at 4359, CACTACCC at 4126, CCCGCCCC at 4101, ACATTCCC at 3824, CAAGTCCC at 3422, CAATCCCC at 3013, ACCCCCCC at 2846, CACCCCCC at 2845, ACCCGCCC at 2816, CCACCCCC at 2623, CCCACCCC at 2622, ACAGGCCC at 2617, AAAAACCC at 2263, CCCTCCCC at 1856, CCCCTCCC at 1855, AACTGCCC at 1850, CCACTCCC at 1674, CAAGCCCC at 1634, CCAAGCCC at 1633, CAATACCC at 1467, AAACCCCC at 1403, CCCCGCCC at 988, ACAGCCCC at 984, AACAGCCC at 983, CCAATCCC at 914, CCCCGCCC at 350, AACTCCCC at 346.
- KRUPr6ci: 16, CAAGGCCC at 4551, CCCGCCCC at 4339, CAATTCCC at 4142, AACACCCC at 3777, CAACACCC at 3776, ACCATCCC at 3707, AACGACCC at 2955, ACCCACCC at 2751, ACCGGCCC at 2430, ACCCTCCC at 2363, CACAACCC at 2359, ACACGCCC at 1675, CCAGGCCC at 1402, CCCGGCCC at 1077, CCCTACCC at 621, AAAGGCCC at 24.
- KRUPr7ci: 15, AACCGCCC at 4437, AAACACCC at 4336, AAAAGCCC at 3887, ACCTCCCC at 3805, AAATTCCC at 3638, CACTTCCC at 3085, AACGTCCC at 2861, CCCACCCC at 2730, CCCGACCC at 2414, AAACCCCC at 1597, AAAACCCC at 1596, CAAAACCC at 1595, AACCTCCC at 1371, CAAAACCC at 811, CACTGCCC at 616.
- KRUPr8ci: 13, AAAACCCC at 4115, AAAAACCC at 4114, CCACTCCC at 4075, AACCACCC at 3131, AACCTCCC at 3036, ACCCCCCC at 2002, AACCACCC at 1587, AAATGCCC at 1379, CCCGACCC at 1107, CCACACCC at 1052, AAAGGCCC at 939, AAAACCCC at 180, CAAAACCC at 179.
- KRUPr9ci: 13, AACCCCCC at 4480, AACATCCC at 3751, CCCGTCCC at 3268, AAACCCCC at 3223, AAAACCCC at 3222, AAAAACCC at 3221, AACTTCCC at 2825, CAAGGCCC at 1826, CCCATCCC at 1785, ACAGCCCC at 420, CACAGCCC at 419, ACAAACCC at 388, CCATCCCC at 81.

## KRUPr arbitrary (evens) (4560-2846) UTRs
- KRUPr0: GGGCCGTT at 4471, GGGTGTTT at 3708, GGGTATTT at 3513, GGGTTGTG at 3019, GGGGTTGT at 3018, GGGCGGTG at 2998.
- KRUPr2: GGGGGGTT at 4301, GGGGGGGT at 4300, GGGGGTGG at 4009, GGGACTTG at 3503, GGGCATTT at 3299.
- KRUPr4: GGGTCGGT at 4243, GGGCGTGG at 3733, GGGGCGTG at 3732.
- KRUPr6: GGGCGGTT at 4352, GGGGCGGT at 4351, GGGTATTG at 4108, GGGGTTTG at 3933, GGGCAGGT at 3799, GGGCATTT at 3747, GGGTGGGG at 3741, GGGCTTGT at 3575.
- KRUPr8: GGGACGTT at 3602, GGGCAGGG at 3535, GGGGGGGG at 3462, GGGTATGT at 3443, GGGGCTTG at 3322, GGGTGTTG at 3302.
- KRUPr0ci: AAACCCCC at 4301, AAAACCCC at 4300, ACCCCCCC at 3159.
- KRUPr2ci: CACAACCC at 3840, AAATGCCC at 3832, CAAGACCC at 3311, CCACCCCC at 3215, ACCACCCC at 3214, AACCACCC at 3213, AACATCCC at 3180.
- KRUPr4ci: ACCTTCCC at 4195, ACATTCCC at 3701, AACCTCCC at 3640, CCAAGCCC at 3272, CAACCCCC at 3155, ACAACCCC at 2858.
- KRUPr6ci: CAAGGCCC at 4551, CCCGCCCC at 4339, CAATTCCC at 4142, AACACCCC at 3777, CAACACCC at 3776, ACCATCCC at 3707, AACGACCC at 2955.
- KRUPr8ci: AAAACCCC at 4115, AAAAACCC at 4114, CCACTCCC at 4075, AACCACCC at 3131, AACCTCCC at 3036.

## KRUPr alternate (odds) (4560-2846) UTRs
- KRUPr1: GGGCTGGG at 3918.
- KRUPr3: GGGTTGTT at 4514, GGGTGTTT at 4497, GGGATTTT at 3757, GGGGATTT at 3756, GGGGCTTT at 3638, GGGCAGGG at 3332.
- KRUPr5: GGGCAGGG at 3907, GGGTCGGG at 3178.
- KRUPr7: GGGTCTTT at 4233, GGGCTTGG at 3724, GGGAAGGG at 3712, GGGCTTTT at 3257, GGGTCTTT at 3093, GGGAGTTG at 2872.
- KRUPr9: GGGAATTG at 4202, GGGACGGT at 3280, GGGCTTGT at 3166.
- KRUPr1ci: CACCCCCC at 4510, CACCGCCC at 3759, ACCCACCC at 3732, ACCTCCCC at 3544, AACCTCCC at 3543, AAACGCCC at 2860.
- KRUPr3ci: CAACGCCC at 4280, CCCGTCCC at 4037, CCCCTCCC at 3831, ACCAGCCC at 3793, CCAGTCCC at 3571, CACCGCCC at 3080.
- KRUPr5ci: AACCCCCC at 4493, CAACCCCC at 4492, CCCAGCCC at 4365, CCCTCCCC at 4359, CACTACCC at 4126, CCCGCCCC at 4101, ACATTCCC at 3824, CAAGTCCC at 3422, CAATCCCC at 3013, ACCCCCCC at 2846.
- KRUPr7ci: AACCGCCC at 4437, AAACACCC at 4336, AAAAGCCC at 3887, ACCTCCCC at 3805, AAATTCCC at 3638, CACTTCCC at 3085, AACGTCCC at 2861.
- KRUPr9ci: AACCCCCC at 4480, AACATCCC at 3751, CCCGTCCC at 3268, AAACCCCC at 3223, AAAACCCC at 3222, AAAAACCC at 3221.

## KRUPr arbitrary negative direction (evens) (2846-2811) core promoters
- KRUPr2: GGGTTTTT at 2824, GGGCGGGT at 2820, GGGGCGGG at 2819.
- KRUPr2ci: CACATCCC at 2811.

## KRUPr alternate negative direction (odds) (2846-2811) core promoters
- KRUPr5ci: ACCCCCCC at 2846, CACCCCCC at 2845, ACCCGCCC at 2816.
- KRUPr9ci: AACTTCCC at 2825.

## KRUPr arbitrary positive direction (odds) (4445-4265) core promoters
- KRUPr3ci: CAACGCCC at 4280.
- KRUPr5ci: CCCAGCCC at 4365, CCCTCCCC at 4359.
- KRUPr7ci: AACCGCCC at 4437, AAACACCC at 4336.

## KRUPr alternate positive direction (evens) (4445-4265) core promoters
- KRUPr2: GGGGGGTT at 4301, GGGGGGGT at 4300.
- KRUPr6: GGGCGGTT at 4352, GGGGCGGT at 4351.
- KRUPr0ci: AAACCCCC at 4301, AAAACCCC at 4300.
- KRUPr6ci: CCCGCCCC at 4339.

## KRUPr arbitrary negative direction (evens) (2811-2596) proximal promoters
- KRUPr2: GGGAGTGT at 2791, GGGGAGTG at 2790, GGGCCGTT at 2702, GGGGAGGT at 2611.
- KRUPr4: GGGATTTT at 2768, GGGGATTT at 2767.
- KRUPr6: GGGAATTT at 2798.
- KRUPr8: GGGCTTGG at 2637.
- KRUPr0ci: AACGACCC at 2629.
- KRUPr2ci: CACATCCC at 2811, ACCCCCCC at 2722.
- KRUPr6ci: ACCCACCC at 2751.

## KRUPr alternate negative direction (odds) (2811-2596) proximal promoters
- KRUPr1: GGGCAGGG at 2653, GGGCCTGT at 2389, GGGCGTTT at 1481, GGGAGGTG at 1172, GGGGAGGT at 1171, GGGCCTTG at 1117, GGGTAGTT at 559, GGGTTTTG at 280.
- KRUPr5: GGGAGGGG at 2753, GGGCCGGG at 2691.
- KRUPr9: GGGTATTT at 2782.
- KRUPr1ci: ACACGCCC at 2665.
- KRUPr5ci: CCACCCCC at 2623, CCCACCCC at 2622, ACAGGCCC at 2617.
- KRUPr7ci: CCCACCCC at 2730.

## KRUPr arbitrary positive direction (odds) (4265-4050) proximal promoters
- KRUPr7: GGGTCTTT at 4233.
- KRUPr9: GGGAATTG at 4202.
- KRUPr5ci: CACTACCC at 4126, CCCGCCCC at 4101.

## KRUPr alternate positive direction (evens) (4265-4050) proximal promoters
- KRUPr4: GGGTCGGT at 4243.
- KRUPr6: GGGTATTG at 4108.
- KRUPr4ci: ACCTTCCC at 4195.
- KRUPr6ci: CAATTCCC at 4142.
- KRUPr8ci: AAAACCCC at 4115, AAAAACCC at 4114, CCACTCCC at 4075.

## KRUPr arbitrary negative direction (evens) (2596-1) distal promoters
- KRUPr0: GGGGCTGG at 2469, GGGGGGGG at 1650, GGGCTGGG at 827, GGGATGTG at 764, GGGTTGTG at 724.
- KRUPr2: GGGCCTTT at 2286, GGGGAGTG at 2160, GGGTTGGG at 1287, GGGGTTGG at 1286, GGGTATTT at 808, GGGAGTGT at 193, GGGAAGGG at 47.
- KRUPr4: GGGTTGTT at 2436, GGGTTTTT at 2426, GGGACTGT at 2416, GGGTAGTT at 2397, GGGTATGG at 1830, GGGACGTT at 1606, GGGTTTTG at 1382, GGGCTTTT at 1345, GGGCCGGT at 355, GGGTAGGG at 33.
- KRUPr6: GGGGGGTT at 2115, GGGACGGT at 1512, GGGAGGTT at 1270, GGGGAGGT at 1269, GGGAGTTG at 430, GGGGAGTT at 429.
- KRUPr8: GGGAGTGG at 2586, GGGTTGTT at 2381, GGGAATTG at 1976, GGGTGTTG at 1596, GGGCAGGT at 1515, GGGCAGGT at 1021, GGGTAGGG at 576, GGGCGGGG at 243, GGGGCGGG at 242, GGGTGGGG at 100, GGGTTTGT at 42.
- KRUPr0ci: ACCCCCCC at 1861, AACCCCCC at 1860, CAACCCCC at 1859, CCCGACCC at 1600, CCCAACCC at 1523, CCCTTCCC at 123, AAATTCCC at 118, CCCTCCCC at 29, ACCCTCCC at 28.
- KRUPr2ci: CCAGCCCC at 2564, CACACCCC at 2425, CACTACCC at 2152, CACCCCCC at 2107, ACCCCCCC at 1622, CACCCCCC at 1621, CCCTCCCC at 959, CCCCTCCC at 958, ACAGCCCC at 952, AACAGCCC at 951.
- KRUPr4ci: AAATACCC at 1781, ACCAGCCC at 1713, CCCCTCCC at 1523, AACACCCC at 1478, CACCACCC at 1150, ACACTCCC at 1056, CCCTACCC at 1037, CCCAGCCC at 1011, CACCCCCC at 917, CAAGTCCC at 632, CAAACCCC at 233, CCAAACCC at 232, CCACCCCC at 101, CCCACCCC at 100, AAACGCCC at 95.
- KRUPr6ci: ACCGGCCC at 2430, ACCCTCCC at 2363, CACAACCC at 2359, ACACGCCC at 1675, CCAGGCCC at 1402, CCCGGCCC at 1077, CCCTACCC at 621, AAAGGCCC at 24.
- KRUPr8ci: ACCCCCCC at 2002, AACCACCC at 1587, AAATGCCC at 1379, CCCGACCC at 1107, CCACACCC at 1052, AAAGGCCC at 939, AAAACCCC at 180, CAAAACCC at 179.

## KRUPr alternate negative direction (odds) (2596-1) distal promoters
- KRUPr1: GGGCCTGT at 2389, GGGCGTTT at 1481, GGGAGGTG at 1172, GGGGAGGT at 1171, GGGCCTTG at 1117, GGGTAGTT at 559, GGGTTTTG at 280.
- KRUPr3: GGGCATTT at 2538, GGGAGTTG at 2263, GGGGAGTT at 2262, GGGTGTGG at 2011, GGGCCGGG at 1991, GGGGCTGG at 1925, GGGAGGGT at 1629, GGGGAGGG at 1628, GGGAGGGG at 1624, GGGATTGG at 1231, GGGACGTT at 630, GGGTTGTT at 530, GGGGCGGG at 519.
- KRUPr5: GGGAGGTT at 2586, GGGGGTTT at 2497, GGGGGGTT at 2496, GGGAATGG at 2341, GGGTTTGT at 2040, GGGCGGGT at 2036, GGGGCGGG at 2035, GGGTTTGT at 1720, GGGTATTT at 1312, GGGTCTGG at 1045, GGGGCTGG at 773, GGGTTGGG at 741, GGGGTTGG at 740, GGGTCGGT at 464, GGGTTGGT at 255, GGGGTTGG at 254, GGGCTTTT at 219, GGGTTGGG at 43, GGGGTTGG at 42.
- KRUPr7: GGGTTGTG at 2139, GGGTTTGG at 1848, GGGCGTGG at 1790, GGGGCGTG at 1789, GGGAGGGG at 1783, GGGTTGTG at 1311, GGGAGGTG at 1260, GGGGAGGT at 1259, GGGCTGTG at 917, GGGGCTGT at 916, GGGCGTGG at 453, GGGTTTTT at 348, GGGTGGGG at 134, GGGATGTG at 118.
- KRUPr9: GGGATTTT at 2140, GGGCCTTT at 1266, GGGCCGTT at 820, GGGTGTTT at 232.
- KRUPr1ci: CCCGACCC at 2355, AACCACCC at 2322, CCCCACCC at 1922, ACAAACCC at 1897, AACGACCC at 1737, AAATGCCC at 1426, CCCGGCCC at 124, ACAGGCCC at 78.
- KRUPr3ci: CAATCCCC at 2495, ACAATCCC at 2494, ACCCCCCC at 2425, AACCCCCC at 2424, AAACCCCC at 2423, AAAACCCC at 2422, CAAAACCC at 2421, CCCTTCCC at 1862, AACTACCC at 1856, CACCTCCC at 1725, CCATTCCC at 1462, CCCAGCCC at 1427, CACCGCCC at 440, AAAGCCCC at 108, CAAAGCCC at 107, CCAGCCCC at 52, CCCAGCCC at 51.
- KRUPr5ci: AAAAACCC at 2263, CCCTCCCC at 1856, CCCCTCCC at 1855, AACTGCCC at 1850, CCACTCCC at 1674, CAAGCCCC at 1634, CCAAGCCC at 1633, CAATACCC at 1467, AAACCCCC at 1403, CCCCGCCC at 988, ACAGCCCC at 984, AACAGCCC at 983, CCAATCCC at 914, CCCCGCCC at 350, AACTCCCC at 346.
- KRUPr7ci: CCCGACCC at 2414, AAACCCCC at 1597, AAAACCCC at 1596, CAAAACCC at 1595, AACCTCCC at 1371, CAAAACCC at 811, CACTGCCC at 616.
- KRUPr9ci: CAAGGCCC at 1826, CCCATCCC at 1785, ACAGCCCC at 420, CACAGCCC at 419, ACAAACCC at 388, CCATCCCC at 81.

## KRUPr arbitrary positive direction (odds) (4050-1) distal promoters
- KRUPr1: GGGCTGGG at 3918, GGGCAGGG at 2653, GGGCCTGT at 2389, GGGCGTTT at 1481, GGGAGGTG at 1172, GGGGAGGT at 1171, GGGCCTTG at 1117, GGGTAGTT at 559, GGGTTTTG at 280.
- KRUPr3: GGGATTTT at 3757, GGGGATTT at 3756, GGGGCTTT at 3638, GGGCAGGG at 3332, GGGCATTT at 2538, GGGAGTTG at 2263, GGGGAGTT at 2262, GGGTGTGG at 2011, GGGCCGGG at 1991, GGGGCTGG at 1925, GGGAGGGT at 1629, GGGGAGGG at 1628, GGGAGGGG at 1624, GGGATTGG at 1231, GGGACGTT at 630, GGGTTGTT at 530, GGGGCGGG at 519.
- KRUPr5: GGGCAGGG at 3907, GGGTCGGG at 3178, GGGAGGGG at 2753, GGGCCGGG at 2691, GGGAGGTT at 2586, GGGGGTTT at 2497, GGGGGGTT at 2496, GGGAATGG at 2341, GGGTTTGT at 2040, GGGCGGGT at 2036, GGGGCGGG at 2035, GGGTTTGT at 1720, GGGTATTT at 1312, GGGTCTGG at 1045, GGGGCTGG at 773, GGGTTGGG at 741, GGGGTTGG at 740, GGGTCGGT at 464, GGGTTGGT at 255, GGGGTTGG at 254, GGGCTTTT at 219, GGGTTGGG at 43, GGGGTTGG at 42.
- KRUPr7: GGGCTTGG at 3724, GGGAAGGG at 3712, GGGCTTTT at 3257, GGGTCTTT at 3093, GGGAGTTG at 2872, GGGTTGTG at 2139, GGGTTTGG at 1848, GGGCGTGG at 1790, GGGGCGTG at 1789, GGGAGGGG at 1783, GGGTTGTG at 1311, GGGAGGTG at 1260, GGGGAGGT at 1259, GGGCTGTG at 917, GGGGCTGT at 916, GGGCGTGG at 453, GGGTTTTT at 348, GGGTGGGG at 134, GGGATGTG at 118.
- KRUPr9: GGGACGGT at 3280, GGGCTTGT at 3166, GGGTATTT at 2782, GGGATTTT at 2140, GGGCCTTT at 1266, GGGCCGTT at 820, GGGTGTTT at 232.
- KRUPr1ci: CACCGCCC at 3759, ACCCACCC at 3732, ACCTCCCC at 3544, AACCTCCC at 3543, AAACGCCC at 2860, ACACGCCC at 2665, CCCGACCC at 2355, AACCACCC at 2322, CCCCACCC at 1922, ACAAACCC at 1897, AACGACCC at 1737, AAATGCCC at 1426, CCCGGCCC at 124, ACAGGCCC at 78.
- KRUPr3ci: CCCGTCCC at 4037, CCCCTCCC at 3831, ACCAGCCC at 3793, CCAGTCCC at 3571, CACCGCCC at 3080, CAATCCCC at 2495, ACAATCCC at 2494, ACCCCCCC at 2425, AACCCCCC at 2424, AAACCCCC at 2423, AAAACCCC at 2422, CAAAACCC at 2421, CCCTTCCC at 1862, AACTACCC at 1856, CACCTCCC at 1725, CCATTCCC at 1462, CCCAGCCC at 1427, CACCGCCC at 440, AAAGCCCC at 108, CAAAGCCC at 107, CCAGCCCC at 52, CCCAGCCC at 51.
- KRUPr5ci: ACATTCCC at 3824, CAAGTCCC at 3422, CAATCCCC at 3013, ACCCCCCC at 2846, CACCCCCC at 2845, ACCCGCCC at 2816, CCACCCCC at 2623, CCCACCCC at 2622, ACAGGCCC at 2617, AAAAACCC at 2263, CCCTCCCC at 1856, CCCCTCCC at 1855, AACTGCCC at 1850, CCACTCCC at 1674, CAAGCCCC at 1634, CCAAGCCC at 1633, CAATACCC at 1467, AAACCCCC at 1403, CCCCGCCC at 988, ACAGCCCC at 984, AACAGCCC at 983, CCAATCCC at 914, CCCCGCCC at 350, AACTCCCC at 346.
- KRUPr7ci: AAAAGCCC at 3887, ACCTCCCC at 3805, AAATTCCC at 3638, CACTTCCC at 3085, AACGTCCC at 2861, CCCACCCC at 2730, CCCGACCC at 2414, AAACCCCC at 1597, AAAACCCC at 1596, CAAAACCC at 1595, AACCTCCC at 1371, CAAAACCC at 811, CACTGCCC at 616.
- KRUPr9ci: AACATCCC at 3751, CCCGTCCC at 3268, AAACCCCC at 3223, AAAACCCC at 3222, AAAAACCC at 3221, AACTTCCC at 2825, CAAGGCCC at 1826, CCCATCCC at 1785, ACAGCCCC at 420, CACAGCCC at 419, ACAAACCC at 388, CCATCCCC at 81.

## KRUPr alternate positive direction (evens) (4050-1) distal promoters
- KRUPr0: GGGTGTTT at 3708, GGGTATTT at 3513, GGGTTGTG at 3019, GGGGTTGT at 3018, GGGCGGTG at 2998, GGGGCTGG at 2469, GGGGGGGG at 1650, GGGCTGGG at 827, GGGATGTG at 764, GGGTTGTG at 724.
- KRUPr2: GGGGGTGG at 4009, GGGACTTG at 3503, GGGCATTT at 3299, GGGTTTTT at 2824, GGGCGGGT at 2820, GGGGCGGG at 2819, GGGAGTGT at 2791, GGGGAGTG at 2790, GGGCCGTT at 2702, GGGGAGGT at 2611, GGGCCTTT at 2286, GGGGAGTG at 2160, GGGTTGGG at 1287, GGGGTTGG at 1286, GGGTATTT at 808, GGGAGTGT at 193, GGGAAGGG at 47.
- KRUPr4: GGGCGTGG at 3733, GGGGCGTG at 3732, GGGATTTT at 2768, GGGGATTT at 2767, GGGTTGTT at 2436, GGGTTTTT at 2426, GGGACTGT at 2416, GGGTAGTT at 2397, GGGTATGG at 1830, GGGACGTT at 1606, GGGTTTTG at 1382, GGGCTTTT at 1345, GGGCCGGT at 355, GGGTAGGG at 33.
- KRUPr6: GGGGTTTG at 3933, GGGCAGGT at 3799, GGGCATTT at 3747, GGGTGGGG at 3741, GGGCTTGT at 3575, GGGAATTT at 2798, GGGGGGTT at 2115, GGGACGGT at 1512, GGGAGGTT at 1270, GGGGAGGT at 1269, GGGAGTTG at 430, GGGGAGTT at 429.
- KRUPr8: GGGACGTT at 3602, GGGCAGGG at 3535, GGGGGGGG at 3462, GGGTATGT at 3443, GGGGCTTG at 3322, GGGTGTTG at 3302, GGGCTTGG at 2637, GGGAGTGG at 2586, GGGTTGTT at 2381, GGGAATTG at 1976, GGGTGTTG at 1596, GGGCAGGT at 1515, GGGCAGGT at 1021, GGGTAGGG at 576, GGGCGGGG at 243, GGGGCGGG at 242, GGGTGGGG at 100, GGGTTTGT at 42.
- KRUPr0ci: ACCCCCCC at 3159, AACGACCC at 2629, ACCCCCCC at 1861, AACCCCCC at 1860, CAACCCCC at 1859, CCCGACCC at 1600, CCCAACCC at 1523, CCCTTCCC at 123, AAATTCCC at 118, CCCTCCCC at 29, ACCCTCCC at 28.
- KRUPr2ci: CACAACCC at 3840, AAATGCCC at 3832, CAAGACCC at 3311, CCACCCCC at 3215, ACCACCCC at 3214, AACCACCC at 3213, AACATCCC at 3180, CACATCCC at 2811, ACCCCCCC at 2722, CCAGCCCC at 2564, CACACCCC at 2425, CACTACCC at 2152, CACCCCCC at 2107, ACCCCCCC at 1622, CACCCCCC at 1621, CCCTCCCC at 959, CCCCTCCC at 958, ACAGCCCC at 952, AACAGCCC at 951.
- KRUPr4ci: ACATTCCC at 3701, AACCTCCC at 3640, CCAAGCCC at 3272, CAACCCCC at 3155, ACAACCCC at 2858, AAATACCC at 1781, ACCAGCCC at 1713, CCCCTCCC at 1523, AACACCCC at 1478, CACCACCC at 1150, ACACTCCC at 1056, CCCTACCC at 1037, CCCAGCCC at 1011, CACCCCCC at 917, CAAGTCCC at 632, CAAACCCC at 233, CCAAACCC at 232, CCACCCCC at 101, CCCACCCC at 100, AAACGCCC at 95.
- KRUPr6ci: AACACCCC at 3777, CAACACCC at 3776, ACCATCCC at 3707, AACGACCC at 2955, ACCCACCC at 2751, ACCGGCCC at 2430, ACCCTCCC at 2363, CACAACCC at 2359, ACACGCCC at 1675, CCAGGCCC at 1402, CCCGGCCC at 1077, CCCTACCC at 621, AAAGGCCC at 24.
- KRUPr8ci: AACCACCC at 3131, AACCTCCC at 3036, ACCCCCCC at 2002, AACCACCC at 1587, AAATGCCC at 1379, CCCGACCC at 1107, CCACACCC at 1052, AAAGGCCC at 939, AAAACCCC at 180, CAAAACCC at 179.

# Kruppel-like factor analysis and results
We "defined the consensus binding site as 5-NGG-GG(T/G)-(T/G)(T/G)(T/G)-3. It differs from the consensus binding sites for  WT-KLF1, 5-NGG-G(C/T)G-(T/G)GG-3, and for  Nan-KLF1, 5-NGG-G(C/A)N-(T/G)GG-3, as well."
Comparison:
The occurrences of real Kruppel-like factors are greater than the randoms for the UTRs, cores, positive direction proximals, and positive direction distals. Real Kruppel-like factors are less than the randoms for the negative direction proximals and negative direction distals, but the high end of the negative direction distals overlaps the low end of the random negative direction distals. This suggests that the real Kruppel-like factors are likely active or activable.