Hyaluronic acid (topical)

# Disclaimer
WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider.  WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery.  The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements.  WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.

# Overview
Hyaluronic acid (topical) is a musculoskeletal agent that is FDA approved for the treatment of osteoarthritis of knee, hair growth and loss prevention.   Common adverse reactions include injection site pain, injection site reaction , arthralgia.

# Adult Indications and Dosage

## FDA-Labeled Indications and Dosage (Adult)

# Indications

## Hyaluronic Acid Solution
- For hair growth and loss prevention
Dosage
- Spray on the scalp 2~3 times daily as needed
- Recommendable to apply enough on the scalp prior to going to bed

## Hyaluronic Acid Injection
- Osteoarthritis of knee
Dosage
- Osteoarthritis of knee: 30 mg per 2 mL (contents of prefilled syringe) INTRA-ARTICULARLY into the knee once weekly for a total of 3 to 4 injections (as a series of 3 to 4 injections each 1 week apart).

## Off-Label Use and Dosage (Adult)

### Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Hyaluronic acid (topical) in adult patients.

### NonGuideline-Supported Use
There is limited information regarding Off-Label NonGuideline-Supported Use of Hyaluronic acid (topical) in adult patients.

# Pediatric Indications and Dosage

## FDA-Labeled Indications and Dosage (Pediatric)
There is limited information regarding FDA-Labeled Use of Hyaluronic acid (topical) in pediatric patients.

## Off-Label Use and Dosage (Pediatric)

### Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Hyaluronic acid (topical) in pediatric patients.

### NonGuideline-Supported Use
There is limited information regarding Off-Label NonGuideline-Supported Use of Hyaluronic acid (topical) in pediatric patients.

# Contraindications
There is limited information regarding Hyaluronic acid (topical) Contraindications in the drug label.

# Warnings
- Stop using and see a doctor if any hypersensitivity symptom continues
- Avoid storing under direct sun light or high temperature

# Adverse Reactions

## Clinical Trials Experience
Dermatologic: Injection site pain, Injection site reaction
Musculoskeletal: arthralgia

## Postmarketing Experience
There is limited information regarding Postmarketing Experience of Hyaluronic acid (topical) in the drug label.

# Drug Interactions
There is limited information regarding Hyaluronic acid (topical) Drug Interactions in the drug label.

# Use in Specific Populations

### Pregnancy
Pregnancy Category (FDA): 
There is no FDA guidance on usage of Hyaluronic acid (topical) in women who are pregnant.
Pregnancy Category (AUS):
- Australian Drug Evaluation Committee (ADEC) Pregnancy Category
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Hyaluronic acid (topical) in women who are pregnant.

### Labor and Delivery
There is no FDA guidance on use of Hyaluronic acid (topical) during labor and delivery.

### Nursing Mothers
There is no FDA guidance on the use of Hyaluronic acid (topical) with respect to nursing mothers.

### Pediatric Use
There is no FDA guidance on the use of Hyaluronic acid (topical) with respect to pediatric patients.

### Geriatic Use
There is no FDA guidance on the use of Hyaluronic acid (topical) with respect to geriatric patients.

### Gender
There is no FDA guidance on the use of Hyaluronic acid (topical) with respect to specific gender populations.

### Race
There is no FDA guidance on the use of Hyaluronic acid (topical) with respect to specific racial populations.

### Renal Impairment
There is no FDA guidance on the use of Hyaluronic acid (topical) in patients with renal impairment.

### Hepatic Impairment
There is no FDA guidance on the use of Hyaluronic acid (topical) in patients with hepatic impairment.

### Females of Reproductive Potential and Males
There is no FDA guidance on the use of Hyaluronic acid (topical) in women of reproductive potentials and males.

### Immunocompromised Patients
There is no FDA guidance one the use of Hyaluronic acid (topical) in patients who are immunocompromised.

# Administration and Monitoring

### Administration
- IV
- Attach a small gauge needle (18- to 21-gauge) to tip of the syringe; inject the full contents of syringe into one knee only.
- If treatment is bilateral, use a separate syringe for each knee.
- For hair scalp spraying only

### Monitoring
- Reduction in pain associated with osteoarthritis of the knee is indicative of efficacy

# IV Compatibility
There is limited information regarding IV Compatibility of Hyaluronic acid (topical) in the drug label.

# Overdosage
There is limited information regarding Hyaluronic acid (topical) overdosage.  If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

# Pharmacology

## Mechanism of Action
There is limited information regarding Hyaluronic acid (topical) Mechanism of Action in the drug label.

## Structure
There is limited information regarding Hyaluronic acid (topical) Structure in the drug label.

## Pharmacodynamics
There is limited information regarding Pharmacodynamics of Hyaluronic acid (topical) in the drug label.

## Pharmacokinetics
There is limited information regarding Pharmacokinetics of Hyaluronic acid (topical) in the drug label.

## Nonclinical Toxicology
There is limited information regarding Nonclinical Toxicology of Hyaluronic acid (topical) in the drug label.

# Clinical Studies
There is limited information regarding Clinical Studies of Hyaluronic acid (topical) in the drug label.

# How Supplied
There is limited information regarding Hyaluronic acid (topical) How Supplied in the drug label.

## Storage
There is limited information regarding Hyaluronic acid (topical) Storage in the drug label.

# Images

## Drug Images

## Package and Label Display Panel

# Patient Counseling Information
There is limited information regarding Patient Counseling Information of Hyaluronic acid (topical) in the drug label.

# Precautions with Alcohol
- Alcohol-Hyaluronic acid (topical) interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

# Brand Names
- Orthovisc
- Monovisc
- Morisu

# Look-Alike Drug Names
There is limited information regarding Hyaluronic acid (topical) Look-Alike Drug Names in the drug label.

# Drug Shortage Status

# Price