Clinical trial NCT01008462: Autologous Peripheral Blood Stem Cell Transplant Followed by Donor Bone Marrow Transplant in Treating Patients With High-Risk Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Multiple Myeloma, or Chronic Lymphocytic Leukemia
Official title: Sequential Autologous HCT / Nonmyeloablative Allogeneic HCT Using Related, HLA-Haploidentical Donors for Patients With High-Risk Lymphoma, Multiple Myeloma, or Chronic Lymphocytic Leukemia
Conditions: B-Cell Prolymphocytic Leukemia
Hypodiploidy
Loss of Chromosome 17p
Plasma Cell Leukemia
Progression of Multiple Myeloma or Plasma Cell Leukemia
Recurrent Adult Hodgkin Lymphoma
Recurrent Adult Non-Hodgkin Lymphoma
Recurrent Childhood Hodgkin Lymphoma
Recurrent Childhood Non-Hodgkin Lymphoma
Recurrent Chronic Lymphocytic Leukemia
Recurrent Plasma Cell Myeloma
Recurrent Small Lymphocytic Lymphoma
Refractory Childhood Hodgkin Lymphoma
Refractory Chronic Lymphocytic Leukemia
Refractory Non-Hodgkin Lymphoma
Refractory Plasma Cell Myeloma
Refractory Small Lymphocytic Lymphoma
t(14;16)
t(4;14)
T-Cell Prolymphocytic Leukemia
Waldenstrom Macroglobulinemia
Summary: This phase II trial studies autologous peripheral blood stem cell transplant followed by donor bone marrow transplant in treating patients with high-risk Hodgkin lymphoma, non-Hodgkin lymphoma, multiple myeloma, or chronic lymphocytic leukemia. Autologous stem cell transplantation uses the patient's stem cells and does not cause graft versus host disease (GVHD) and has a very low risk of death, while minimizing the number of cancer cells. Peripheral blood stem cell (PBSC) transplant uses stem cells from the patient or a donor and may be able to replace immune cells that were destroyed by chemotherapy. These donated stem cells may help destroy cancer cells. Bone marrow transplant known as a nonmyeloablative transplant uses stem cells from a haploidentical family donor. Autologous peripheral blood stem cell transplant followed by donor bone marrow transplant may work better in treating patients with high-risk Hodgkin lymphoma, non-Hodgkin lymphoma, multiple myeloma, or chronic lymphocytic leukemia.
Interventions:
description: Undergo donor HCT
name: Allogeneic Bone Marrow Transplantation
other_name: Allo BMT
Allogeneic BMT
type: Procedure
description: Undergo donor HCT
name: Allogeneic Hematopoietic Stem Cell Transplantation
other_name: Allogeneic Hematopoietic Cell Transplantation
Allogeneic Stem Cell Transplantation
HSC
HSCT
type: Procedure
description: Undergo autologous PBSC transplant
name: Autologous Hematopoietic Stem Cell Transplantation
other_name: Autologous Hematopoietic Cell Transplantation
autologous stem cell transplantation
type: Procedure
description: Undergo autologous-donor tandem HCT
name: Autologous-Allogeneic Tandem Hematopoietic Stem Cell Transplantation
other_name: auto-allo HCT
type: Procedure
description: Given IV
name: Carmustine
other_name: BCNU
Becenum
Becenun
BiCNU
Bis(chloroethyl) Nitrosourea
Bis-Chloronitrosourea
Carmubris
Carmustin
Carmustinum
FDA 0345
Gliadel
N,N'-Bis(2-chloroethyl)-N-nitrosourea
Nitrourean
Nitrumon
SK 27702
SRI 1720
WR-139021
type: Drug
description: Given IV
name: Cyclophosphamide
other_name: (-)-Cyclophosphamide
2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate
CP monohydrate
CTX
CYCLO-cell
Carloxan
Ciclofosfamida
Ciclofosfamide
Cicloxal
Clafen
Claphene
Cycloblastin
Cycloblastine
Cyclophospham
Cyclophosphamid monohydrate
Cyclophosphamidum
Cyclophosphan
Cyclophosphane
Cyclophosphanum
Cyclostin
Cyclostine
Cytophosphan
Cytophosphane
Cytoxan
Fosfaseron
Genoxal
Genuxal
Ledoxina
Mitoxan
Neosar
Revimmune
Syklofosfamid
WR- 138719
type: Drug
description: Given IV
name: Cytarabine
other_name: .beta.-Cytosine arabinoside
1-.beta.-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone
1-.beta.-D-Arabinofuranosylcytosine
1-Beta-D-arabinofuranosyl-4-amino-2(1H)pyrimidinone
1-Beta-D-arabinofuranosylcytosine
1.beta.-D-Arabinofuranosylcytosine
2(1H)-Pyrimidinone, 4-Amino-1-beta-D-arabinofuranosyl-
2(1H)-Pyrimidinone, 4-amino-1.beta.-D-arabinofuranosyl-
ARA-cell
Alexan
Ara-C
Arabine
Arabinofuranosylcytosine
Arabinosylcytosine
Aracytidine
Aracytin
Aracytine
Beta-cytosine Arabinoside
CHX-3311
Cytarabinum
Cytarbel
Cytosar
Cytosine Arabinoside
Cytosine-.beta.-arabinoside
Cytosine-beta-arabinoside
Erpalfa
Starasid
Tarabine PFS
U 19920
U-19920
Udicil
WR-28453
type: Drug
description: Given IV
name: Etoposide
other_name: Demethyl Epipodophyllotoxin Ethylidine Glucoside
EPEG
Lastet
Toposar
VP 16-213
VP-16
VP-16-213
Vepesid
type: Drug
description: Given IV
name: Fludarabine Phosphate
other_name: 2-F-ara-AMP
9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)-
Beneflur
Fludara
SH T 586
type: Drug
description: Correlative study
name: Laboratory Biomarker Analysis
type: Other
description: Given IV
name: Melphalan
other_name: Alanine Nitrogen Mustard
CB-3025
L-PAM
L-Phenylalanine Mustard
L-Sarcolysin Phenylalanine mustard
L-Sarcolysine
L-sarcolysin
Melphalanum
Phenylalanine Mustard
Phenylalanine nitrogen mustard
Sarcoclorin
Sarkolysin
WR-19813
type: Drug
description: Given PO
name: Mycophenolate Mofetil
other_name: Cellcept
MMF
type: Drug
description: Undergo donor HCT
name: Peripheral Blood Stem Cell Transplantation
other_name: PBPC transplantation
PBSCT
Peripheral Blood Progenitor Cell Transplantation
Peripheral Stem Cell Support
Peripheral Stem Cell Transplant
Peripheral Stem Cell Transplantation
type: Procedure
description: Given IV or PO
name: Tacrolimus
other_name: FK 506
Fujimycin
Hecoria
Prograf
Protopic
type: Drug
description: Undergo TBI
name: Total-Body Irradiation
other_name: Total Body Irradiation
Whole-Body Irradiation
type: Radiation
Study arms:
design_group_description: See Detailed Description
design_group_title: Treatment (autologous HCT, donor HCT)
design_group_type: Experimental
Sponsor: Fred Hutchinson Cancer Research Center
Collaborators: National Cancer Institute
Drug name mappings:
name: 依托泊苷
lang: CN
name: Etoposide
lang: EN
name: エトポシド
lang: JP
name: 磷酸氟达拉滨
lang: CN
name: Fludarabine Phosphate
lang: EN
name: フルダラビンリン酸エステル
lang: JP
name: 环磷酰胺
lang: CN
name: Cyclophosphamide
lang: EN
name: シクロホスファミド水和物
lang: JP
name: 卡莫司汀
lang: CN
name: Carmustine
lang: EN
name: カルムスチン
lang: JP
name: 美法仑
lang: CN
name: Melphalan
lang: EN
name: メルファラン
lang: JP
name: 他克莫司
lang: CN
name: Tacrolimus
lang: EN
name: タクロリムス水和物
lang: JP
name: 吗替麦考酚酯
lang: CN
name: Mycophenolate Mofetil
lang: EN
name: ミコフェノール酸 モフェチル
lang: JP
name: 阿糖胞苷
lang: CN
name: Cytarabine
lang: EN
name: シタラビン
lang: JP