English:
[0001] With more than 563,000 deaths in the United States annually, cancer is the second leading cause of death behind heart disease (UBS Warburg "Disease Dynamics: The Cancer Market," Nov. 8, 2000). Surgery and radiotherapy may be curative if the disease is found early, but current drug therapies for metastatic disease are mostly palliative and seldom offer a long-term cure. Even with the new chemotherapies entering the market, improvement in patient survival is measured in months rather than in years, and the need continues for new drugs effective both in combination with existing agents as first line therapy and as second and third line therapies in treatment of resistant tumors.
[0002] A need remains in the art for improved cell proliferation disorder and cancer treatments.
[0003] The invention relates to compounds and methods of using the compounds to treat cell proliferation disorders.
[0004] The compounds of the present invention are useful as pharmaceutical agents. For example the compounds may be useful as antiproliferative agents, for treating mammals, such as for treating humans and animals. The compounds may be used without limitation, for example, as anti-cancer, anti-angiogenesis, anti-metastatic, anti-microbial, anti-bacterial, antifungal, anti-parasitic and/or anti-viral agents. The compounds of the invention are useful, for example, in treating lung cancer. The compounds of the invention are also useful, for example, in treating colon cancer. The compounds of the invention are also useful, for example, in treating breast cancer.
[0005] The compounds of the invention are useful in treating diseases and disorders that are modulated by tyrosine kinase inhibition. For example, the compounds of the invention are useful in treating diseases and disorders that are modulated by Src kinase. The compounds of the invention may also be useful in treating diseases and disorders that are modulated by focal adhesion kinase (FAK).
[000249] All percentages and ratios used herein, unless otherwise indicated, are by weight.

中文:
[0001]在美国每年超过563,000的死亡中,癌症是仅次于心脏病的第二大主要死因(UBS Warburg′′Disease Dynamics:TheCancer Market,′′Nov.8,2000)。如果疾病发现的早,外科手术和放射线疗法可能是有效的治疗方法,但是目前对转移性癌症的药物治疗主要起到减轻的作用,很少能够提供一种长期的治疗。尽管一种新的化学疗法进入市场,但是对病人存活期的改善只能用月而非年来计算,所以仍然需要新的药物。这种新的药物能够结合作为治疗恶性肿瘤的第一线治疗和作为第二线、第三线治疗的现存药物而发挥有效的作用。
[0002]在此领域仍然存在对改善细胞增殖紊乱和癌症治疗方法的需要。
[0003]本发明关于化合物及利用这些化合物治疗细胞增殖紊乱的方法。
[0004]本发明中的化合物作为药物制剂是有用的。例如作为抗增殖剂的化合物用于治疗哺乳动物如人和动物时,是有用的。这类化合物的有用性是无局限的,例如,作为抗癌的,抗血管发生的,抗新陈代谢的,抗微生物的,抗菌的,抗真菌的,抗寄生物的和/或抗滤过性病原体的制剂都是有用的。本发明的化合物在治疗肺癌,结肠癌以及治疗乳腺癌上也都是有用的。
[0005]本发明的化合物可以有效的治疗受酪氨酸激酶抑制剂调控的疾病和紊乱。例如,这些化合物可以有效的治疗受Src激酶调控的疾病和紊乱。这些化合物还可以有效地治疗受粘着斑激酶(FAK)调控的疾病和紊乱也是有用的。
[000249]在这里使用的全部的百分比和比率,除非另有说明,都是质量百分比和比率。