A Bifunctional Coordination Polymer for Al3+ Ion Detection and its Treatment Effect on Nonalcoholic Fatty Liver Disease by Promoting Lipoxygenases and Reducing Intrahepatic Triglyceride Content
Authors: Jingyuan Wang
Quan Shao
Miaojuan Wang
Jie-Peng Jia
Ji-Jun Zhang
Journal: Journal of Fluorescence (2021)
Discipline: CHEMISTRY
Keywords: Cd(II)-complex; Coordination polymer; Liver cell; Luminescent sensor; Mixed-ligand
Affiliations: Department of General Surgery, Sixth Hospital of Shanxi Medical University, Taiyuan, Shanxi, China., Department of General Surgery, Sixth Hospital of Shanxi Medical University, Taiyuan, Shanxi, China. ., Department of Medical Center, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.

Abstract:  In this study, a new Cd(II)-bearing coordination polymer with the chemical formula of {[Cd4(meda)3(dpe)4(H2O)4]·(NO3)2·2(H2O)}n (1, H2meda = 3,3'-methylenedibenzoic acid, dpe = 1,2-di(pyridin-4-yl)ethane) has been successfully prepared by reaction of Cd(NO3)·4H2O with a V-shape carboxyl ligand H2meda along with the linear dipyridine ligand dpe under the hydrothermal conditions. Due to its intensive luminescence, complex 1 could be utilized as the sensor of detecting Al3+ ion, and its detection limit is 4 × 10-6 M. Firstly, the toxicity of the compound on the normal liver cells was determined with Cell Counting Kit-8 detection kit. The triglyceride in liver cells was detected by detection kit after compound treatment and the relative expression of 15-lox and 12-lox in L02 cells was also measured by RT-PCR after compound treatment. In addition, multiple functional groups that provided by the synthesized Cd(II) complex have been studied by using molecular docking simulation for the confirmation of possible binding modes that formed between ligand and receptor. 

Retracted: No

PubPeer comments:
 Could the authors explain the reasoning behind their choices of References?  Non-alcoholic fatty liver disease (NAFLD) refers to the lipid droplets excessive accumulation in the liver. It is known as a series of pathologies related to abnormal accumulation of liver fat [1, 2]. - [2]. Chen W, Chang L, Ren SB, He ZC, Huang GB, Liu XH (2020) **Direct Z-scheme 1D 2D WO2.72 ZnIn2S4 hybrid photocatalysts with highly-efficient visible-light-driven photodegradation towards tetracycline hydrochloride removal**. J Hazard Mater 384:121308  According to the recent reports NAFLD is the most common and top cause of liver disease in the United States, which affects almost to a third of the total population, causing a heavy burden for the people [3]. - [3]. Kaul U, Parmar D, Manjunath K, Shah M, Parmar K, Patil KP, Jaiswal A (2019) New dual peroxisome proliferator activated receptor agonist-Saroglitazar in diabetic dyslipidemia and nonalcoholic fatty liver disease: integrated analysis of the real world evidence. Cardiovasc Diabetol 18:80  A new research about metabolomics in NASH patients showed that the production of lipoxygenase pathway products increases, which indicating an abnormal activity about lipoxygenases in the liver, the most well studied enzymes are 15-LOX and 12-LOX [5, 6]. - [6]. Zhao J, Xin M, Zhang J, Sun Y, Luo S, Wang H, Wang Y, Bi X (2020) **Diclofenac inhibited the biological phosphorus removal: performance and mechanism**. Chemosphere 243:125380 , 
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