Pluripotency of mesenchymal stem cells derived from adult marrow
Authors: Catherine M Verfaillie
Robert E Schwartz
Aaron Lisberg
Sara Aldrich
C Dirk Keene
R Lee Reinhardt
Walter C Low
Morayma Reyes
Yuehua Jiang
Balkrishna N Jahagirdar
Todd Lenvik
Xilma R Ortiz-Gonzalez
Jingbo Du
David A Largaespada
Mark Blackstad
Troy Lund
Journal: Nature (2002)
Discipline: Multidisciplinary
Keywords: mesenchymal stem cells; multipotent adult progenitor cells; differentiation; single cell level; visceral mesoderm
Affiliations: Stem Cell Institute, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA.

Abstract:  We report here that cells co-purifying with mesenchymal stem cells--termed here multipotent adult progenitor cells or MAPCs--differentiate, at the single cell level, not only into mesenchymal cells, but also cells with visceral mesoderm, neuroectoderm and endoderm characteristics in vitro. When injected into an early blastocyst, single MAPCs contribute to most, if not all, somatic cell types. On transplantation into a non-irradiated host, MAPCs engraft and differentiate to the haematopoietic lineage, in addition to the epithelium of liver, lung and gut. Engraftment in the haematopoietic system as well as the gastrointestinal tract is increased when MAPCs are transplanted in a minimally irradiated host. As MAPCs proliferate extensively without obvious senescence or loss of differentiation potential, they may be an ideal cell source for therapy of inherited or degenerative diseases. 

Retracted: No

PubPeer comments:
 March 2021 retraction found here: https: cdnsciencepub.com doi 10.1139 bcb-2021-0079 It reads:  u201c*GBP1 exerts inhibitory effects on acute viral myocarditis by inhibiting the inflammatory response of macrophages in miceu201d (Zhao et al. 2018) has been retracted at the authorsu2019 request due to errors in the results presented for their flow cytometry experiments, e.g., as presented in Fig. 7a. The retraction was initiated by Ping Yang at the request of all authors with agreement from the Editors-in-Chief. This retraction is consistent with the publishing policy of Biochemistry and Cell Biology and its publisher, Canadian Science Publishing.* I could not find an immediate problem in Figure 7A, but the Western blots in Figures 1D and 5B look remarkably similar to those found in the  Tadpole paper mill papers. This paper thus appears too belong to a set of over 500 papers that share very similar Western blots with tadpole-like shaped bands, the same background pattern, and striking similarities in title structures, paper layout, bar graph design, and - in a subset - flow cytometry panels. Despite these similarities, these papers are authored by researchers from different departments and institutes, with almost no overlap in authors. The list of these papers is available here: https: docs.google.com spreadsheets d 1KXqTAyl4j-jVorFPMD2XRpr76LcIKJ0CVyIvRj0exYQ edit?usp=sharing A more detailed description of this set of papers, suspected to all be generated by a common source, a paper mill , can be found here: https: forbetterscience.com 2020 01 24 the-full-service-paper-mill-and-its-chinese-customers (January 2020) https: scienceintegritydigest.com 2020 02 21 the-tadpole-paper-mill (February 2020) The same paper mill has been described in these papers: Jana Christopher - Systematic fabrication of scientific images revealed - FEBS Letters (2018) - https: febs.onlinelibrary.wiley.com doi full 10.1002 1873-3468.13201 Jennifer A Byrne and Jana Christopher - Digital magic, or the dark arts of the 21st centuryu2014how can journals and peer reviewers detect manuscripts and publications from paper mills? - FEBS Letters (2020) - https: febs.onlinelibrary.wiley.com doi full 10.1002 1873-3468.13747 Here is Figure 5B for illustration: ![file] , 
 #1 There is no doubt that the paper was a papermill product. With the benefit of hindsight, though I suggest that the source was **not** the  Tadpole papermill . This style of WBs, resembling strings of sausages, are one manifestation of [the  Contractor papermill] , discussed here: - https: forbetterscience.com 2020 09 14 dead-horses-wont-flog-themselves - https: forbetterscience.com 2021 09 22 the-scientific-sea-of-mir-and-exosome-related-knowledge ![file] The artisanal hand-stippled flow-cytometry scatterplots are also associated with that source. ![file] ,