Involvement of human primary somatosensory cortex in vibrotactile detection depends on task demand
Authors: Luigi Tamè
Nicholas P Holmes
Journal: NeuroImage (2016)
Discipline: NEUROSCIENCE & BEHAVIOR
Keywords: sensory stimuli; nervous system; primary somatosensory cortex; discrimination; detection
Affiliations: Centre for Integrative Neuroscience & Neurodynamics, School of Psychology & Clinical Language Sciences, University of Reading, Reading, UK; Center for Mind/Brain Sciences, University of Trento, Rovereto, Italy; Department of Psychological Sciences, Birkbeck, University of London, London, UK. Electronic address: ., School of Psychology, University of Nottingham, Nottingham, UK.

Abstract:  Detecting and discriminating sensory stimuli are fundamental functions of the nervous system. Electrophysiological and lesion studies suggest that macaque primary somatosensory cortex (SI) is critically involved in discriminating between stimuli, but is not required simply for detecting stimuli. By contrast, transcranial magnetic stimulation (TMS) studies in humans have shown near-complete disruption of somatosensory detection when a single pulse of TMS is delivered over SI. To address this discrepancy, we measured the sensitivity and decision criteria of participants detecting vibrotactile stimuli with individually-tailored fMRI-guided TMS over SI, over a control site not activated by vibrotactile stimuli (inferior parietal lobule, IPL), or away from the head (a no TMS condition). In a one-interval detection task, TMS increased participants' likelihood of reporting 'no' target present regardless of site, but TMS over SI also decreased detection sensitivity, and prevented improvement in tactile sensitivity over time. We then measured tactile thresholds in a series of two-interval forced-choice (2IFC) detection and discrimination tasks with lower dependence on response criteria and short-term memory load. We found that thresholds for detecting stimuli were comparable with TMS over SI and IPL, but TMS over SI specifically and significantly impaired frequency discrimination. We conclude that, in accordance with macaque studies, human SI is required for discriminating between tactile stimuli and for maintaining stimulus representations over time, or under high task demand, but may not be required for simple tactile detection. Significant statement: Studies on monkeys have suggested that the primary somatosensory cortex is responsible for discriminating between different vibrations on the fingertips, but not just for detecting these vibrations. However, similar studies in humans suggest that the somatosensory cortex is required both for detecting and discriminating between tactile stimuli. We used magnetic brain stimulation to interfere with human somatosensory cortex while healthy volunteers detected and discriminated between vibrations applied to their fingertips. We found that the somatosensory cortex is required for keeping vibrotactile stimuli in memory for short periods of time and for comparing two vibrotactile stimuli, but is not required merely for detecting vibrotactile stimulation. This suggests that human primary somatosensory cortex is not always needed for vibrotactile detection. 

Retracted: No

PubPeer comments:
 This paper was criticised as part of a self-reflection posted on Twitter on 2nd-3rd April, 2021 Criticism: This paper is in my all-time top-3. BUT: The time-window analysis shown in Figure 4 is a fudge. The stats are OK, but I picked the filter settings that *looked* best, after trying lots (e.g., average over 10 trials, 20, 30...). The stats were done only once - comparing the first and second halves of the block - it would be tricky noisy to get enough trials to calculate d-prime with any smaller divisions of the data. The decision to divide data into two halves was post-hoc. ,