AR-induced long non-coding RNA LINC01503 facilitates proliferation and metastasis via the SFPQ-FOSL1 axis in nasopharyngeal carcinoma
Authors: Qian Li
Shi-Wei He
Cheng Xu
Yuan Lei
Jun Ma
Ying-Qin Li
Ying-Qing Li
Pan-Pan Zhang
Yin Zhao
Na Liu
Jun-Yan Li
Ye-Lin Liang
Sheng-Yan Huang
Yang Chen
Journal: Oncogene (2020)
Discipline: MOLECULAR BIOLOGY & GENETICS
Keywords: lncRNAs; tumorigenesis; progression; nasopharyngeal carcinoma; LINC01503
Affiliations: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, No. 651 Dongfeng Road East, Guangzhou, 510060, Guangdong, China., Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, No. 651 Dongfeng Road East, Guangzhou, 510060, Guangdong, China. .

Abstract:  Increasing evidence indicates that long non-coding RNAs (lncRNAs) play vital roles in the tumorigenesis and progression of cancers. However, the functions and regulatory mechanisms of lncRNAs in nasopharyngeal carcinoma (NPC) are still largely unknown. Our previous lncRNA expression profiles identified that LINC01503 was overexpressed in NPC. Here, we verified that LINC01503 was highly expressed in NPC and correlated with poor prognosis. LINC01503 promoted NPC cell proliferation, migration, and invasion in vitro, and facilitated tumor growth and metastasis in vivo. Mechanistically, LINC01503 recruited splicing factor proline-and glutamine-rich (SFPQ) to activate Fos like 1 (FOSL1) transcription, and ectopic expression of FOSL1 reversed the suppressive effect of LINC01503 knockdown on NPC progression. Moreover, androgen receptor (AR)-mediated transcription activation was responsible for the overexpression of LINC01503, and AR ligand-dependent cell growth, migration, and invasion in NPC cells. Taken together, our findings reveal that AR-induced LINC01503 can promote NPC progression through the SFPQ-FOSL1 axis, which represents a novel prognostic biomarker and therapeutic target for NPC patients. 

Retracted: No

PubPeer comments:
 In figure 2f,g, a micrograph has been duplicated and presented as something else. ![file] , 
 Dear Tanganyikensis, Thank you for your comment about our article, and we apologize for our mistake, and for any inconvenience caused by this. We realized that we accidentally applied the same micrograph in Figures 2f and 2g. Then, we have checked our raw data and corrected it (Figure 2f and 2g) as following. We also had applied for correct this mistake for Oncogene publisher. Thank you! Yours sincerely!![file] , 
 See also Supplemental Figure 2d. These types of errors are sometimes seen in papers produced by paper mills as they presumably work through their supply of images. *** ![file] , 
 Correction Published: 11 October 2021 Following the publication of the above article, the authors (sic) noted two errors in Fig. 2 and Supplementary Fig. 2, in which the images of HK1 shCtrl group in Fig. 2g and 5-8F 1503 OE group at 0u2009h in Supplemental Fig. 2 were misused and have been replaced. The authors confirm that the mistakes do not affect the results and conclusions of the study and apologize for any inconvenience caused by this mistake. The corrected figures were provided below. The original article has been corrected. ![file] , 
 An image in this paper seems to overlap with an image in another paper. Readers should note that the field of view for both images is different, suggesting that whomever prepared this figure had access to a larger original image. I did not see any common authors on the two papers. I will drop a note to both journals. Figure 5d Oncogene (2020) doi: 10.1038 s41388-020-01388-8 https: pubpeer.com publications 2D356269DA57B0E4F1A973F5C40668 Figure 5D Frontiers in Oncology (2021) doi: 10.3389 fonc.2021.715635 https: pubpeer.com publications EE06E13CA8568C4869A1F0D77DE276 *** ![file] , 
 Dear Actinopolyspora biskrensis, Thank you very much for your comments. When received your comments, I immediately questioned the first authors of the two papers: Shi-Wei He (Oncogene, 2020) and Hui-Yun Yang (Front Oncol, 2021). Hui-Yun Yang is a doctoral student in Central South University. She previously applied to carry out her doctoral research in our Laboratory for one year, and she did some experiments in our Lab from May 2019 to May 2020. She told me she mistakenly downloaded the raw data from our Lab public computer, which is linked with a microscope for images capture and storage in our Lab. I apologize for the negligence in the management of the Lab, and I will strengthen the Lab management in future. Again, thank you. Yours sincerely, Na Liu ,