A New Mixed-Ligand Ni(II) Complex: Crystal Structure, Protective and Anti-Inflammatory Activities of its Nanoparticles on Acute Viral Myocarditis by Reducing the Release of Inflammatory Cytokines TNF-α and IL-1β
Authors: Zhao, M.
Zhang, Z. -F.
Huo, W. -X.
Bai, D. -S.
Liu, X. -T.
Journal: Journal of Structural Chemistry (2020)
Discipline: CHEMISTRY
Keywords: mixed-ligand strategy; Ni(II)-bearing coordination complex; nanoparticles; anti-inflammatory activity; acute viral myocarditis model

Abstract: By means of the mixed-ligand strategy, a new Ni(II)-bearing coordination complex [Ni(pda)(bimb)(H2O)](H2O)1.5(1, bimb = 6,6′-bis(1H-benzo[d]imidazol-2-yl)-2,2′-bipyridine, H2pda = 4,4′-(pyridine-2,6-diyl)dibenzoic acid) is successfully obtained by the reaction of Ni(NO3)2·6H2O, bimb, and H2pda under hydrothermal reaction conditions. Furthermore, the nanoparticles of 1 (nano-1) with a size distribution of around 160 nm can be produced via a grinding method. In the section of biological research, we describe the anti-inflammatory activity of nano-1 on the acute viral myocarditis model. In the CVB3-induced acute viral myocarditis model, the treatment effect of nano-1 is evaluated by determining the mice survival rate and the CVB3 titer. The anti-inflammatory activity of nano-1 is determined by the ELISA assay of TNF-α and IL-1β levels in plasma.

Retracted: No

PubPeer comments:
 A cluster of references are cited in one another s company in more papers than one would expect, with little regard for their relevance to the context, almost as if papers are being assembled by following a template. See e.g. [Gan et al (2020)] , [Wu Lian (2020)] .  The structure and design of metal-involved supramolecular architectures based on crystal engineering are currently of interest in the field of supramolecular and coordination chemistry [6]. The increasing interest in this field is justified not only by their valuable unit structure, but also their potential applications in luminescence, catalysis, and biochemistry, particularly in modern medicinal chemistry [7-10]. - [7]. C. Duan, F. Li, M. Yang, H. Zhang, Y. Wu, and H. Xi. Ind. Eng. Chem. Res., 2018, 57, 15385. * Rapid synthesis of hierarchically structured multifunctional metalu2013organic zeolites with enhanced volatile organic compounds adsorption capacity * - [8]. L. Niu, J. L. Xu, W. L. Yang, C. H. Kang, J. Q. Ma, and J. Q. Su. Sci. Adv. Mater., 2019, 11, 466. ** Synergistic Effect Between Nano-Sb2O3 and Brominated Epoxy Resin on the Flame Retardancy of Poly(butylene terephthalate) ** - [9]. Y. Y. Yang, L. Kang, and H. Li. Ceram. Int., 2019, 45, 8017. ** Enhancement of photocatalytic hydrogen production of BiFeO3 by Gd3+ doping ** - [10]. H. Zhao, X. Mu, C. Zheng, S. Liu, Y. Zhu, X. Gao, and T. Wu. J. Hazard. Mater., 2019, 366, 240. ** Structural defects in 2D MoS2 nanosheets and their roles in the adsorption of airborne elemental mercury ** , 
 This is one of a large number of coordination-chemistry papers that appear to have all been written according to a template. - All draw on the same small pool of papers to illustrate the broad range of applications and properties of MOFs. Even when the in-text citations match the references, one might expect independent authors to think of different examples. - Many cite Zhao, Kang and Yao (2019) -- **Research and Application of Acoustic Emission Signal Processing Technology** -- which is completely irrelevant to the topic, but became part of the template anyway. - The vast majority of email identities for corresponding authors were formed by taking an underscore-separated name and appending 666 or 66 . I am advised that these are auspicious numbers with positive associations. So one possibility is that the authors all decided independently to generate email accounts with this format. The alternative is that *some outside contractor* handled the task of negotiating with journals (generating these disposable accounts in the process) - perhaps also the task of writing the manuscripts, using a single Bibliography file to save time. For a (partial) list [see here] . In the following, (some of) the recurring References are labelled 1 to 14 . Searching for other papers that cite them might be informative. ------------------------------ - [1]. D. M. Chen, J. Y. Tian, Z. W. Wang, C. S. Liu, M. Chen, and M. Du (2017). Chem. Commun. 53, 10668.  An anionic Na(i)u2013organic framework platform: separation of organic dyes and post-modification for highly sensitive detection of picric acid - [2]. H. Du, C. Ma, W. Ma, and H. Wang. Process. Appl. Ceram., 2018, 12, 303  Microstructure evolution and dielectric properties of Ce-doped SrBi4Ti4O15 ceramics synthesized via glycine-nitrate process - [3]. C. Duan, J. Huo, F. Li, M. Yang, H. Xi, J. Mater. Sci. 53 (2018) 16276.  Ultrafast room-temperature synthesis of hierarchically porous metalu2013organic frameworks by a versatile cooperative template strategy - [4]. C. Duan, F. Li, M. Yang, H. Zhang, Y. Wu and H. Xi, Rapid Synthesis of Hierarchically Structured Multifunctional Metalu2013Organic Zeolites with Enhanced Volatile Organic Compounds Adsorption Capacity, Ind Eng Chem Res 57 (2018), 15385u201315394. - [5]. C. Duan, H. Zhang, F. Li, J. Xiao, S. Luo, and H. Xi. Soft Matter, 2018, 14, 9589.  Hierarchically porous metalu2013organic frameworks: rapid synthesis and enhanced gas storage - [6]. Y. Feng, M. Li, H. Fan, Q. Huang, D. Qiu, and H. Shi (2015). Dalton Trans. 44, 894.  A novel open-framework copper borophosphate containing 1-D borophosphate anion with 10-MR windows and 12-MR channels - [7]. L. Kang, H.L. Du, X. Du, H.T. Wang, W.L. Ma, M.L. Wang and F.B. Zhang, Study on dye wastewater treatment of tunable conductivity solid-waste-based composite cementitious material catalyst, Desalin Water Treat 125 (2018), 296u2013301. - [8]. L. Kang, L. Zhao, S. Yao, C. Duan, Ceram. Int. 45 (2019) 16717.  A new architecture of super-hydrophilic u03b2-SiAlON graphene oxide ceramic membrane for enhanced anti-fouling and separation of water oil emulsion - [9]. L. Niu, J. L. Xu, W. L. Yang, C. H. Kang, J. Q. Ma, and J. Q. Su. Sci. Adv. Mater., 2019, 11, 466.  Synergistic Effect Between Nano-Sb2O3 and Brominated Epoxy Resin on the Flame Retardancy of Poly(butylene terephthalate) - [10]. Y.Y. Yang, L. Kang, H. Li, Ceram. Int. 45 (2019) 8017.  Enhancement of photocatalytic hydrogen production of BiFeO3 by Gd3+ doping - [11]. Y. Yang, H. Li, W. Zheng, Y. Bai, Z. Liu, J. Zhang, Sci. Adv. Mater. 11 (2019) 208.  Experimental study on calcining process of secondary coated ceramsite solidified chromium contaminated soil - [12]. L. Zhao, L. Kang, and S. Yao (2019). IEEE Access 7, 984.  Research and Application of Acoustic Emission Signal Processing Technology - [13]. H. Zhao, X. Mu, C. Zheng, S. Liu, Y. Zhu, X. Gao, T. Wu, Structural defects in 2D MoS2 nanosheets and their roles in the adsorption of airborne elemental mercury, J. Hazard Mater. 366 (2019) 240u2013249. - [14]. Y. Feng, H. Fan, Z. Zhong, H. Wang and D. Qiu, Cd3(MoO4)(TeO3)2: A Polar 3D Compound Containing d10u2013d0 SCALP-Effect Cations, Inorg Chem 55 (2016), 11987u201311992. ,