Physiological Responses and Prognostic Value of Common Exercise Testing Modalities in Idiopathic Pulmonary Fibrosis
Authors: Jonathan Myers
Avraham Unterman
Mordechai Reuven Kramer
Shimon Izhakian
Baruch Vainshelboim
Jose Oliveira
Journal: Journal of cardiopulmonary rehabilitation and prevention (2019)
Discipline: CLINICAL MEDICINE
Keywords: physiological responses; cycle cardiopulmonary exercise tests; CPETs; 6-min walk tests; 6MWTs
Affiliations: Master of Cancer Care Program, School of Health Sciences, Saint Francis University, Loretto, Pennsylvania (Dr Vainshelboim); Pulmonary Institute, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel (Drs Vainshelboim, Izhakian, Unterman, and Kramer); Research Center in Physical Activity, Health and Leisure (CIAFEL), Faculty of Sport, University of Porto, Portugal (Drs Vainshelboim and Oliveira); Cardiology Division, Veterans Affairs Palo Alto Health Care System/Stanford University, California (Dr Myers); Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel (Drs Izhakian, Unterman, and Kramer).

Abstract:  Purpose: This pilot study aimed to compare physiological responses between cycle cardiopulmonary exercise tests (CPETs) and 6-min walk tests (6MWTs) and to assess their prognostic value among patients with idiopathic pulmonary fibrosis (IPF). Methods: Thirty-four patients with IPF (68 ± 8 yr) underwent CPETs and 6MWTs and were followed up for 40 mo. Differences, levels of agreement, and relative risks for mortality were analyzed between measured and estimated peak responses for the 2 tests. Results: Compared with the CPET, oxygen uptake ((Equation is included in full-text article.)O2), heart rate (HR), and the nadir of SpO2 were lower during the 6MWT, whereas work rate (WR) was higher. Mean differences were as follows: (Equation is included in full-text article.)O2 =-1.9 mL/kg/min, 95% CI, -1.1 to -2.7, P &lt; .001; HR =-9 beats/min, 95% CI, -4 to -14, P = .002; SpO2 =-6%, 95% CI, -4 to -7, P &lt; .001; and WR = 9 W/min, 95% CI, 3 to 16, P = .008. Interclass correlations ranged from 0.84 to 0.90 and both tests demonstrated prognostic value for mortality. Conclusions: Significant differences and variation in peak physiological responses were observed between cycle CPETs and 6MWTs in patients with IPF. However, good agreement was evident, suggesting that both tests provide value for clinical and research settings. Future studies should compare the physiological responses between treadmill CPETs and 6MWTs for prognostic utility in IPF. 

Retracted: No

PubPeer comments:
 Copy pasted from https: retractionwatch.com 2021 04 26 elsevier-journal-to-retract-widely-debunked-masks-study-whose-author-claimed-a-stanford-affiliation :  (......) Stanford isnu2019t the only bogus credential Vainshelboim has used as an author. He often lists an affiliation with Rabin Medical Center, in Israel. However, according to an email we have seen from a faculty member at the institution, Vainshelboim has not been on staff there for at least eight years and never held a professorship, as he has claimed in biographies. In his 2019 article, u201cPhysiological Responses and Prognostic Value of Common Exercise Testing Modalities in Idiopathic Pulmonary Fibrosis,u201d Vainshelboim has three institiontional affiliations: Stanford, Rabin Medical Center and the School of Health Sciences at Saint Francis University, in Loretto, Pa. (The official title is the School of Health Sciences Education.) That last one does appear to be true, according to this 2019 press release. However, the deanu2019s office for the school told us that Vainshelboim is no longer with the university. Donald Walkovich, the dean of the School of Health Sciences Education, confirmed that Vainshelboim worked there between August 2017 and May 2019, but would not discuss the reason for his departure. (......) ,