RETRACTED ARTICLE: Association of the polymorphisms in FOXO1 gene and diabetic nephropathy risk
Authors: Yongbin Pei
Yukun Li
Xiaoxue Bao
Jianxia Ma
Peng Xue
Yan Wang
Journal: Artificial Cells Nanomedicine and Biotechnology (2019)
Discipline: BIOLOGY & BIOCHEMISTRY
Keywords: diabetic nephropathy; haplotypes; polymorphisms.
Affiliations: Department of Endocrinology, The Third Hospital of Hebei Medical University, Shijiazhuang, China;, Department of General Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, China

Abstract:  Purpose: This study was aimed to study the hypothesis that forkhead box O1 (FOXO1) gene rs17446614 and rs17592236 single nucleotide polymorphisms (SNPs) influenced the development of diabetic nephropathy (DN). Methods: This study included 138 DN patients and 149 healthy controls. Controls were matched with the patients in age and gender. The method of polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) was used to detect FOXO1 gene polymorphisms. Haploview software was conducted to analyze the linkage disequilibrium and haplotypes of FOXO1 gene polymorphisms. Relative risk of DN was expressed by odds ratios (ORs) and 95% confidence intervals (95% CIs), then the results were adjusted by clinical characteristics of the study subjects using logistic regression analysis. Subgroup analysis was performed according to gender. Results: AA genotype of rs17446614 SNPs was significantly associated with the risk of DN (P = .037, adjusted OR = 5.412, 95% CI = 1.103-26.559), especially in female (OR = 8.700, 95% CI = 1.008-75.062, P = .021). FOXO1 rs17446614 A allele positively associated with the development of DN (P = .027, adjusted OR = 1.680, 95% CI = 1.060-2.662), particularly in women (OR = 2.003, 95% CI = 1.070-3.749, P = .028). A-C haplotype formed by FOXO1 gene rs17446614 and rs17592236 SNPs was significantly associated with the increased risk of DN (P = .011, OR = 1.850, 95% CI = 1.146-2.986). Conclusion: FOXO1 gene rs17446614 SNP, and the A-C haplotype of rs17446614 and rs17592236 polymorphisms were risk factors for the development of DN. 

Retracted: Yes

PubPeer comments:
 Retracted [11 January 2021] . ------------------------------------------- We, the Editors and Publisher of the journal Artificial Cells, Nanomedicine, and Biotechnology, have retracted the following article: Jianxia Ma, Yongbin Pei, Peng Xue, Yan Wang, Xiaoxue Bao Yukun Li (2019) Association of the polymorphisms in FOXO1 gene and diabetic nephropathy risk. Artificial Cells, Nanomedicine, and Biotechnology, 47:1, 1471-1475, DOI: 10.1080 21691401.2019.1601103 It has come to our attention that the full authorship list and affiliations for this manuscript, including the study site and ethics committee, were changed after the article was submitted. We have contacted the authors for an explanation, but we have not received a response within the requested timeframe. As determining authorship and the location of where the research was conducted is core to the integrity of published work, we are therefore retracting the article. The authors listed in this publication have been sent notification. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as u2018Retractedu2019. ,