Whey protein but not collagen peptides stimulate acute and longer-term muscle protein synthesis with and without resistance exercise in healthy older women: a randomized controlled trial
Authors: Michael J Kamal
Steven K Baker
Chris McGlory
Stuart M Phillips
Sara Y Oikawa
Erin K Webb
Journal: American Journal of Clinical Nutrition (2020)
Discipline: CLINICAL MEDICINE
Keywords: collagen peptides; muscle protein synthesis; older women; protein quality; resistance exercise
Affiliations: Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada., Department of Neurology, Michael G DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

Abstract:  Background: Aging appears to attenuate the response of skeletal muscle protein synthesis (MPS) to anabolic stimuli such as protein ingestion (and the ensuing hyperaminoacidemia) and resistance exercise (RE). Objectives: The purpose of this study was to determine the effects of protein quality on feeding- and feeding plus RE-induced increases of acute and longer-term MPS after ingestion of whey protein (WP) and collagen protein (CP). Methods: In a double-blind parallel-group design, 22 healthy older women (mean ± SD age: 69 ± 3 y, n = 11/group) were randomly assigned to consume a 30-g supplement of either WP or CP twice daily for 6 d. Participants performed unilateral RE twice during the 6-d period to determine the acute (via [13C6]-phenylalanine infusion) and longer-term (ingestion of deuterated water) MPS responses, the primary outcome measures. Results: Acutely, WP increased MPS by a mean ± SD 0.017 ± 0.008%/h in the feeding-only leg (Rest) and 0.032 ± 0.012%/h in the feeding plus exercise leg (Exercise) (both P &lt; 0.01), whereas CP increased MPS only in Exercise (0.012 ± 0.013%/h) (P &lt; 0.01) and MPS was greater in WP than CP in both the Rest and Exercise legs (P = 0.02). Longer-term MPS increased by 0.063 ± 0.059%/d in Rest and 0.173 ± 0.104%/d in Exercise (P &lt; 0.0001) with WP; however, MPS was not significantly elevated above baseline in Rest (0.011 ± 0.042%/d) or Exercise (0.020 ± 0.034%/d) with CP. Longer-term MPS was greater in WP than in CP in both Rest and Exercise (P &lt; 0.001). Conclusions: Supplementation with WP elicited greater increases in both acute and longer-term MPS than CP supplementation, which is suggestive that WP is a more effective supplement to support skeletal muscle retention in older women than CP.This trial was registered at clinicaltrials.gov as NCT03281434. 

Retracted: No

PubPeer comments:
 Copy pasted from https: doi.org 10.1093 ajcn nqaa275 :  Corrigendum for Oikawa et al, u201cWhey protein but not collagen peptides stimulate acute and longer-term muscle protein synthesis with and without resistance exercise in healthy older women: a randomized controlled trialu201d Am J Clin Nutr 2020;111(3):708u201318. https: doi.org 10.1093 ajcn nqz332 Dr. Stuart Phillips reports personal fees from Enhanced Recovery and equity from Exerkine, outside the submitted work. In addition, Dr. Phillips has a patent 3,052,324 issued to Exerkine, and a patent 16 182,891 pending to Exerkine. The author apologies for this omission. The American Journal of Clinical Nutrition, Volume 112, Issue 6, December 2020, Page 1656. Published: 10 December 2020. See https: retractionwatch.com 2021 02 12 eleven-papers-corrected-after-nutrition-prof-fails-to-disclose-patent-company-ties for backgrounds. ,