Bisphenols exert detrimental effects on neuronal signaling in mature vertebrate brains
Authors: Peter Machnik
Stefan Schuster
Elisabeth Schirmer
Journal: Communications Biology (2021)
Discipline: BIOLOGY & BIOCHEMISTRY
Keywords: Bisphenols; plasticizers; biosphere; adult brain; homeostatic mechanisms
Affiliations: Department of Animal Physiology, University of Bayreuth, Bayreuth, Germany., Department of Animal Physiology, University of Bayreuth, Bayreuth, Germany. .

Abstract:  Bisphenols are important plasticizers currently in use and are released at rates of hundreds of tons each year into the biosphere1-3. However, for any bisphenol it is completely unknown if and how it affects the intact adult brain4-6, whose powerful homeostatic mechanisms could potentially compensate any effects bisphenols might have on isolated neurons. Here we analyzed the effects of one month of exposition to BPA or BPS on an identified neuron in the vertebrate brain, using intracellular in vivo recordings in the uniquely suited Mauthner neuron in goldfish. Our findings demonstrate an alarming and uncompensated in vivo impact of both BPA and BPS-at environmentally relevant concentrations-on essential communication functions of neurons in mature vertebrate brains and call for the rapid development of alternative plasticizers. The speed and resolution of the assay we present here could thereby be instrumental to accelerate the early testing phase of next-generation plasticizers. 

Retracted: No

PubPeer comments:
 This paper appears to be heavily spun, though I haven t found an original version of text that it was spun from. It may just be a very poor translation. Sample phrases that appear spun are  cross breed bolster vector machine for  mixed support vector machine ,  fake neural systems for  artificial neural networks , and  conjugal condition for  marital status What s a bit more interesting are the references, which in many cases seem to have no relation to statements they cited on. Intro paragraph: ![file] For ref 8, on the statement  In the most recent two decades, a few quantitative strategies have been produced for the confirmation choice , we have the below paper, which has to do with stock forecasting models, not credit approval decisions (which is what I think  confirmation choice means). Perhaps the models described in the lit review of this reference are applicable, but there s no connection drawn. Cheng, Ching-Hsue, Tai-Liang Chen, and Liang-Ying Wei. u201cA Hybrid Model Based on Rough Sets Theory and Genetic Algorithms for Stock Price Forecasting.u201d _Information Sciences_ 180, no. 9 (2010): 1610u201329. For refs 10,11, on the statement  The individual finance score models are created to sort candidates as either acknowledged or rejected concerning the candidatesu2019 attributes, for example, age, pay, and conjugal condition . Neither of these appear relevant to this statement. In particular, reference 11 is a review of particle swarm optimization techniques, and this paper doesn t refer to PSOs at all. (10) Ding, Shifei, Han Zhao, Yanan Zhang, Xinzheng Xu, and Ru Nie. u201cExtreme Learning Machine: Algorithm, Theory and Applications.u201d _Artificial Intelligence Review_ 44, no. 1 (June 2015): 103u201315. (11) Esmin, Ahmed A. A., Rodrigo A. Coelho, and Stan Matwin. u201cA Review on Particle Swarm Optimization Algorithm and Its Variants to Clustering High-Dimensional Data.u201d _Artificial Intelligence Review_ 44, no. 1 (June 2015): 23u201345. Reference 3, for  Officers required in gathering the back are confronted with the issue of attempting to expand volume of individual finance score without exorbitantly expanding their presentation to default , may be somewhat relevant, as it has to do with improving genetic algorithm convergence. Cao, D. Y., and J. X. Cheng. u201cA Genetic Algorithm Based on Modified Selection Operator and Crossover Operator.u201d _Computer Technology and Development_ 20, no. 2 (2010): 44u201347. Reference 18, for  Thusly, to screen the applications, new procedures ought to be produced to anticipate the back to be brought about more precisely , is a survey of swarm intelligence algorithms, which seems to have no relevance statement it s supposed to support. Karaboga, Dervis, Beyza Gorkemli, Celal Ozturk, and Nurhan Karaboga. u201cA Comprehensive Survey: Artificial Bee Colony (ABC) Algorithm and Applications.u201d _Artificial Intelligence Review_ 42, no. 1 (2014): 21u201357. Reference 22, for  The advantages of individual finance score include diminishing the investigation cost individual back score, empowering quicker choices, nearer checking of existing records and organizing the accumulations of individual back score. , is a survey of solutions to the cell formation problem in manufacturing, which seems to have nothing to do with the  advantages of individual finance scores . Papaioannou, Grammatoula, and John M. Wilson. u201cThe Evolution of Cell Formation Problem Methodologies Based on Recent Studies (1997u20132008): Review and Directions for Future Research.u201d _European Journal of Operational Research_ 206, no. 3 (2010): 509u201321. The next para of section 1 starts with  Mechanical advancements have empowered theu2019 money related sectoring industry to open up productive conveyance channels. Data and innovation has helped the money related sectoring industry to manage the difficulties the new economy postures (6). and cites a retraction (retracted due to a peer review ring). The original paper appears to have nothing to do with what it s supposed to support, based on its abstract. ![file] abstract (see http: repository.ncku.edu.tw handle 987654321 146951) The stability analysis of a genetic algorithm-based adaptive neural network controller for a nonlinear system is discussed. First, we track the reference trajectory for an uncertain and nonlinear plant. We make sure that it is well approximated and described using the structure of a radial based function network. Then, we decide on the initial values of the consequent parameter vector utilizing a genetic algorithm. Next, a modified adaptive neural network controller is proposed to simultaneously stabilize and control the system. A stability criterion is also derived from Lyapunov s direct method to ensure the stability of the nonlinear system. Finally, we discuss an example and provide a numerical simulation. The results demonstrate that the control methodology can rapidly and efficiently control a complex and nonlinear system. At the end of section 3, we have this statement, referencing (1) and (16): As indicated by such information relating, best ten classes under which fakes have been accounted for by budgetary segments are given in the Fig. 1 underneath. Figure 1 is a list of top scams, which include  cash credit account ,  cash transactions ,  term loans . Neither citation mentions financial fraud, however both have an author in common with this paper, Haoxiang Wang. (1) Bakshi, Sambit, Pankaj K. Sa, Haoxiang Wang, Soubhagya Sankar Barpanda, and Banshidhar Majhi. u201cFast Periocular Authentication in Handheld Devices with Reduced Phase Intensive Local Pattern.u201d _Multimedia Tools and Applications_ 77, no. 14 (July 2018): 17595u2013623. (16) Huang, Wenzhun, Haoxiang Wang, Yucheng Zhang, and Shanwen Zhang. u201cA Novel Cluster Computing Technique Based on Signal Clustering and Analytic Hierarchy Model Using Hadoop.u201d _Cluster Computing_ 22, no. 6 (November 1, 2019): 13077u201384. , 
 It wasn t easy at all, but here you go: [Huang et al., 2007, doi: 10.1016 j.eswa.2006.07.007] * Recently, competition in the consumer credit market has become severe. With the rapid growth in the credit industry, credit scoring models have been extensively used for the credit admission evaluation (Thomas, 2000). In the last two decades, several quantitative methods have been developed for the credit admission decision. The credit scoring models are developed to categorize applicants as either accepted or rejected with respect to the applicantsu2019 characteristics such as age, income, and marital condition. Credit officers are faced with the problem of trying to increase credit volume without excessively increasing their exposure to default. Therefore, to screen credit applications, new techniques should be developed to help predict credits more accurately. The benefits of credit scoring involve reducing the credit analysis cost, enabling faster credit decisions, closer monitoring of existing accounts and prioritizing credit collections (Brill, 1998). , 
 Thanks, Alexander, for finding that match. A large part of Zhang et al (2019) is spun from that paper (Huang et al (2007)). There are large chunks of Zhang that I haven t matched yet, so i suspect there s another paper involved. I ll look more later. Here s the overlap I ve found so far from these two papers. Most of the Zhang et al (2019) abstract is spun from that paper (Zhang et al 2019 on right, Huang et al (2007) on left): ![file] The first para of the intro is from the same paper, as Alexander found (Zhang et al 2019 on right, Huang et al (2007) on left): ![file] The lit review of Zhang et al (2019) (right) is entirely spun from Huang et al (2007) (left): ![file] Section 6 of Zhang et al (2019) (right) is totally spun from section 3 of Huang et al (2007) (left): ![file] ![file] Figure 4 of Zhang et al (2019) (right) is figure 1 and 2 of Huang et al (2007) (left), which the latter credits to Liu and Motoda (1998). ![file] Section 7 of Zhang et al (2019) (right) is partially spun from section 4.3.2 of Huang et al (2007): ![file] Almost the entire conclusion of Huang et al (2007) (left)) has been spun into the conclusion of Zhang et al (2019) (right): ![file] ![file] ---- Huang, Cheng-Lung, Mu-Chen Chen, and Chieh-Jen Wang. u201cCredit Scoring with a Data Mining Approach Based on Support Vector Machines.u201d _Expert Systems with Applications_ 33, no. 4 (2007): 847u201356. [https: doi.org 10.1016 j.eswa.2006.07.007] . Liu, Huan, and Hiroshi Motoda. Feature Selection for Knowledge Discovery and Data Mining. Kluwer Academic, 1998. , 
 I found a match for a good bit of the rest of the paper. There s still a bit of text in this paper I haven t accounted for, but I think this is enough for now. To summarize, the text appears to be largely spun from at least two papers with citations changed to seemingly unrelated papers. The rest of the abstract and intro of Huang et al (2007) (right) appears to be spun from Chitra and Subashini (2013) (left) (which is a whole nother storyu2014I ve found a few close to identical papers with different authors; Citra and Subashini is the earliest I ve found of that bunch so far; I ll post about those separately): ![file] Section 4, 4.1 and parts of 4.2 of of Huang et al (2007) (right) also match Chitra and Subashini (2013) (left): ![file] ![file] ![file] And the first part of the conclusion matches the same paper (Huang et al (2007) (right); Chitra and Subashini (2013) (left)): ![file] --- Chitra, Dr K., and B. Subashini. u201cData Mining Techniques and Its Applications in Banking Sector.u201d _International Journal of Emerging Technology and Advanced Engineering_ 3, no. 8 (2013). [http: citeseerx.ist.psu.edu viewdoc download?doi=10.1.1.413.9171 rep=rep1 type=pdf](http: citeseerx.ist.psu.edu viewdoc download?doi=10.1.1.413.9171 rep=rep1 type=pdf). , 
 https: pubpeer.com search?q=%22harry+wang%22+OR+%22haoxiang+wang%22 Lots of irrelevant self-citation here.  As indicated by such information relating, best ten classes under which fakes have been accounted for by budgetary segments are given in the Fig. 1 underneath [1,16]. - [1]. Bakshi, S., Sa, P.K., **Wang, H.**, Barpanda, S.S., Majhi, B.: Fast periocular authentication in handheld devices with reduced phase intensive local pattern. Multimed. Tools Appl. https: doi.org 10. 1007 s11042-017-4965-6 (2017) - [16]. Huang, W., **Wang, H.**, Zhang, Y., et al.: Clust. Comput. (2017). https: doi.org 10.1007 s10586-017-1205-9 [A novel cluster computing technique based on signal clustering and analytic hierarchy model using hadoop]  Include choice is a vital issue in building arrangement frameworks [2,4,31,33]. - [2]. Bi, C., **Wang, H.**, Bao, R.: SAR image change detection using regularized dictionary learning and fuzzy clustering. In: 2014 IEEE 3rd International Conference on Cloud Computing and Intelligence Systems (CCIS), November 2014, pp. 327u2013330. IEEE (2014) - [33]. Zhang, S., **Wang, H.**, Huang, W.: Clust. Comput. 20, 1517 (2017). https: doi.org 10.1007 s10586-017-0859-7 [Two-stage plant species recognition by local mean clustering and Weighted sparse representation classification]  To effectively assemble individual finance score models, this study attempted three bolster vector machine-based procedures, for example, utilizing lattice pursuit to advance model parameters, utilizing network inquiry to streamline display parameters and utilizing F-measure figuring to choose input components, and utilizing GA to at the same time enhance show parameters and information highlights [20,26]. - [20]. Liang, R.Z., Shi, L., **Wang, H.**, Meng, J., Wang, J.J.Y., Sun, Q., Gu, Y.: Optimizing top precision performance measure of content-based image retrieval by learning similarity function. In: 2016 23rd International Conference on Pattern Recognition (ICPR), December 2016, pp. 2954u20132958.  Other than the framework algorithm, other streamlining instruments, for example, GA, which is received in this study, can likewise be connected to upgrade the element subset and model parameter [29]. - [29]. **Wang, H.**, Wang, J.: An effective image representation method using kernel classification. In: 2014 IEEE 26th International Conference on Tools with Artificial Intelligence (ICTAI), November 2014, pp. 853u2013858. IEEE (2014)  Misrepresentation examples can be comparative in substance and appearances however ordinarily are not indistinguishable [30,32]. - [30. Wang, J., **Wang, H.**, Zhou, Y., McDonald, N.: Multiple kernel multivariate performance learning using cutting plane algorithm. In: 2015 IEEE International Conference on Systems, Man, and Cybernetics (SMC), October 2015, pp. 1870u20131875. IEEE (2015) ,