A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial
Authors: Adrian Chabowski
Kirsten E Bell
Dinesh Kumbhare
Gianni Parise
Stuart M Phillips
Tim Snijders
Michael Zulyniak
Journal: PLoS ONE (2017)
Discipline: Multidisciplinary
Keywords: Protein; anabolic effects; skeletal muscle; nutritional supplement; strength
Affiliations: Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, ON, Canada., NUTRIM, Department of Human Biology and Movement Sciences, Maastricht University Medical Center, Maastricht, The Netherlands., Department of Medicine, McMaster University, Hamilton, ON, Canada., Department of Physiology, Medical University of Bialystok, Bialystok, Poland.

Abstract:  Protein and other compounds can exert anabolic effects on skeletal muscle, particularly in conjunction with exercise. The objective of this study was to evaluate the efficacy of twice daily consumption of a protein-based, multi-ingredient nutritional supplement to increase strength and lean mass independent of, and in combination with, exercise in healthy older men. Forty-nine healthy older men (age: 73 ± 1 years [mean ± SEM]; BMI: 28.5 ± 1.5 kg/m2) were randomly allocated to 20 weeks of twice daily consumption of either a nutritional supplement (SUPP; n = 25; 30 g whey protein, 2.5 g creatine, 500 IU vitamin D, 400 mg calcium, and 1500 mg n-3 PUFA with 700 mg as eicosapentanoic acid and 445 mg as docosahexanoic acid); or a control (n = 24; CON; 22 g of maltodextrin). The study had two phases. Phase 1 was 6 weeks of SUPP or CON alone. Phase 2 was a 12 week continuation of the SUPP/CON but in combination with exercise: SUPP + EX or CON + EX. Isotonic strength (one repetition maximum [1RM]) and lean body mass (LBM) were the primary outcomes. In Phase 1 only the SUPP group gained strength (Σ1RM, SUPP: +14 ± 4 kg, CON: +3 ± 2 kg, P &lt; 0.001) and lean mass (LBM, +1.2 ± 0.3 kg, CON: -0.1 ± 0.2 kg, P &lt; 0.001). Although both groups gained strength during Phase 2, upon completion of the study upper body strength was greater in the SUPP group compared to the CON group (Σ upper body 1RM: 119 ± 4 vs. 109 ± 5 kg, P = 0.039). We conclude that twice daily consumption of a multi-ingredient nutritional supplement increased muscle strength and lean mass in older men. Increases in strength were enhanced further with exercise training. Trial registration: ClinicalTrials.gov NCT02281331. 

Retracted: No

PubPeer comments:
 Copy pasted from a correction at https: doi.org 10.1371 journal.pone.0243876 :  The following information is missing from the Competing Interests statement: A preliminary patent application was filed by McMaster University on behalf of SMP and GP prior to publication. The rights to this patent are now assigned to Exerkine Corporation for the multi-nutrient supplement used in this study. This patent is now published as International Patent No. WO 2018 157258, September 7, 2018. Additionally, the Data Availability statement for this paper is incorrect. The correct statement is: Data underlying the study are available on the OSF repository at DOI: 10.17605 OSF.IO H35QC Published: December 15, 2020 See https: retractionwatch.com 2021 02 12 eleven-papers-corrected-after-nutrition-prof-fails-to-disclose-patent-company-ties for backgrounds. ,