Two Zn(II)-based Coordination Polymers: Fe3+ Ion and Prevention Activity Detection On Postpartum Hemorrhage By Regulating Anticoagulant Factor Activity
Authors: Xiao-Qing Tan
Miao Liang
Xia Wu
Xiao-Ling Gan
Yan Qin
Yu Wen
Journal: Journal of Fluorescence (2020)
Discipline: CHEMISTRY
Keywords: Coordination polymer; ELISA assay; Fe3+ sensor; postpartum hemorrhage.
Affiliations: Gynaecology and Obstetrics, Chongqing General Hospital, Chongqing, China., Gynaecology and Obstetrics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. .

Abstract:  Two new Zn(II)-based coordination polymers {[Zn3(L1)6(H2O)]∙(H2O)4}n (1, HL1 = 4-(tetrazol-5-yl)phenyl-4,2':6',4″-terpyridine) and [Zn2Cl2(L2)2H2O]n (2, HL2 = 4-([2,2':6',2″'-terpyridin]-4'-yl)benzoic acid) have been successfully prepared using two similar organic ligands with distinct donor groups under similar reaction conditions. The distinct structural features and donor atoms make the two complexes show different water stability, and the complex 1 with good water stability, which can be utilized as the sensor for Fe3+ ion detection in water. The value of Stern-Volmer quenching constant of 1 to the Fe3+ is 5.77 × 104 M- 1, which lies in the top region of the reported CP-based sensors. The mechanism investigation reveals that the energy transfer of resonance from the complex 1 to the Fe3+ ion can account for its fluorescent quenching behavior. The treatment activity of compounds 1 and 2 on the postpartum hemorrhage (PPH) was assessed. First, the cytotoxicity of compounds 1 and 2 on human umbilical vein endothelial cells was assessed with Cell Counting Kit-8 detection kit. Then, to evaluate the prevention of compounds 1 and 2 on the PPH, we conducted the Lowry method and detected the clotting factor IX and anticoagulant factor III contents after the indicated treatment. Finally, the inflammatory response in mice was determined by ELISA method, and the IL-6 and IL-8 levels were determined. 

Retracted: No

PubPeer comments:
 Are the authors sure that References [8-10] are about coordination polymers?  As a type of multipurpose materials, coordination polymers have been widely studied by chemists in the past because of their unique structures and latent applications in luminescence, catalysis, magnetism, gas storage, electrochemistry. and so on [5u201310]. - [8]. Zhang D, Wang MM, Jiang N, Liu Y, Yu XN, Zhang HB (2020) **Electrochemical corrosion behavior of Ni-doped ZnO thin film coated on low carbon steel substrate in 3.5% NaCl solution**. Int J Electrochem Sci 15:4117u20134126 - [9]. Du H, Ma C, Ma W, Wang H (2018) **Microstructure evolution and dielectric properties of Ce-doped SrBi4Ti4O15 Ceramics synthesized via glycine-nitrate process**. Process Appl Ceram 12:303u2013312 - [10]. Liu W, Li H, Zhu H, Xu P (2020) **The interfacial adhesion performance and mechanism of a modified asphaltu2013steel slag aggregate**. Materials 13:1180 , 
 Readers might wonder  What mice?! , as the authors forgot to specify any, or to describe what was done to them. - Finally, the inflammatory response in mice was determined by ELISA method, and the IL-6 and IL-8 levels were determined. - In brief, the mice were treated with compounds 1 and 2 at 5 mg kg concentration, and the same PBS volume was used as the negative control for the animal treatment - In brief, the mice were treated by compounds 1 and 2 at 5 mg kg concentration, and the identical PBS volume was used as the negative control for the animal Well done, journal editors and reviewers! , 
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