Luminescent Coordination Polymer for Picric Acid Detection and Treatment on Spinal Cord Injury Model Via Upregulating the trka Expression
Authors: Jin-Ju Xue
Yong-Gang Ma
Zhi Zhang
Ming Deng
Cheng-Hu Wang
Bin Sheng
Journal: Journal of Fluorescence (2020)
Discipline: CHEMISTRY
Keywords: Fluorescent sensor; Picric acid detection; Spinal cord injury; Tb(III)-MOF.
Affiliations: Department of orthopedics, Liaocheng People's Hospital, Liaocheng, Shandong, China., Department of orthopedics, Liaocheng People's Hospital, Liaocheng, Shandong, China. ., Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei, China., Department of Geriatrics, Haikou People's Hospital, Haikou, Hainan, China.

Abstract:  A luminescent coordination polymer based on Tb(III) has been synthesized with the tripodal carboxylic acid ligand containing N,O codonors (H2PBA = 5-[4-pyridin-3-yl-benzoylamino]-isophthalic acid) as ligand under solvothermal conditions. The chemical formula of this polymer is {[Tb2(PBA)3(H2O)3]·DMF·3H2O}n (1). Complex 1 has good sensitivity and selectivity to picric acid (PA). At 0-30 μmol/L, 1's quenching constant is 4.5 × 104 L/mol. In the biological function study, the motor function of spinal cord-injured animals after different treatments was evaluated using the blood-brain barrier (BBB) method. The trka expression level on the neural stem cells after treatment was measured to reveal the underlying mechanism. 

Retracted: No

PubPeer comments:
 It appears that the authors wrote an introduction for a piece about squamous-cell carcinoma, and kept most of the References when they altered it for a customer who wanted something about stem-cells and spinal injury. Other References were completely irrelevant to either topic, so required no alteration.  Spinal cord injury is a common physical trauma that usually occurs in traffic, working conditions, and sport accidents. Given the lack of effective treatment methods, spinal cord injury clinical treatment has always been widely investigated worldwide [1, 2] - [1]. Lin S, Zhou M, Li Y, Chen Y, Xu W, Xia W, Wang S, Yin R, Zhang Q, Xu L (2019) H3K27 trimethylation and H3K9 dimethylation as poor prognostic markers for patients with **esophageal squamous cell carcinoma**. Int J Clin Exp Patho 12:2657u20132664 - [2]. Zhou M, Li Y, Lin S, Chen Y, Qian Y, Zhao Z, Fan H (2019) H3K9me3, H3K36me3, and H4K20me3 expression correlates with patient outcome in **esophageal squamous cell carcinoma as epigenetic markers**. Digest Dis Sci 64:2147u20132157  At present, spinal cord injury treatment includes three strategies [3u20135]: controlling the secondary injury, including surgical decompression, hormone shock therapy, free radical scavenging; promoting the axonal regeneration and the repair of damaged myelin, including the transplantation of stem cell and the application of nerve growth factor; and removing the factors that inhibit axonal regeneration. - [3]. Su J, Sheng Z, Leung VCM, Chen Y (2019) **Energy efficient tag identification algorithms for RFID: survey, motivation and new design**. IEEE Wirel Commun 26:118u2013124 - [4]. Tang S, Wang Z, Yuan D, Zhang Y, Qi J, Rao Y, Lu G, Li B, Wang K, Yin K (2020) **Enhanced photocatalytic performance of BiVO4 for degradation of methylene blue under LED visible light irradiation assisted by peroxymonosulfate**. Int J Electrochem Sci 15: 2470u20132480 - [5]. Gautam P, Marasini RP, Shrestha R, Gautam P, Marasini L (2019) Quality of life in patients with spinal cord injury attending selected rehabilitation centers of Nepal. J Nepal Health Res Counc 17:297u2013300  The function and application of neural stem cells, which provide a novel strategy for spinal cord injury treatment, have been increasingly studied [6]. - [6]. Duan C, Yu Y, Yang P, Zhang X, Li F, Li L, Xi H (2020) Engineering new defects in MIL-100(Fe) via a mixed-ligand approach to effect enhanced volatile organic compound adsorption capacity. Ind Eng Chem Res 59:774u2013782 , 
 Figs 2a b. ![file] Please compare with *[left]* Fig 2b from [Hou et al (2020)] . *[right]* Fig 2b from [Ma et al (2020)] . Many other appearances of the same TGA curve are listed in those threads. ![] Here superimposed: ![] , 
 *[left]* Fig 2c,  SEM image of MOF 1 . *[right]* Fig 3d from [Lu et al (2020)] ,  The SEM diagrams of complexes 1 and 2 . ![file] UPDATE: Another sighting! Fig. 4 from [Cui et al (2020)] .  The SEM pictures of complexes 1 (a) and 2 (b) before the sonochemical treatment. ![] Another sighting! Fig S1 from [Feng et al (2021)] . ![] ,