Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart
Authors: Reinier A Boon
Stefanie Dimmeler
Leon de Windt
Rosa M Nevado
Thomas Thum
Shambhabi Chatterjee
Carlo G Tocchetti
Mauro Giacca
Serena Zacchigna
Joost P G Sluijter
Christian Bär
Patrícia Rodrigues
Rosalinda Madonna
Stephane Heymans
Vicente Andrés
Marida Sansonetti
Michele Ciccarelli
Stefan Engelhardt
Inês Falcão Pires
Nazha Hamdani
Raquel Figuinha Videira
Journal: Cardiovascular Research (2020)
Discipline: CLINICAL MEDICINE
Keywords: Aging; Cardiovascular disease; MicroRNA; Non-coding RNA; Non-coding RNA therapy
Affiliations: Institute for Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany, REBIRTH Center for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany, Cardiovascular Research and Development Center, Faculty of Medicine of the University of Porto, Porto, Portugal, Cardiovascular Research and Development Center, Faculty of Medicine, University of Porto, Porto, Portugal, Experimental Cardiology Laboratory, UMC Utrecht Regenerative Medicine Center, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands, Department of Physiology, Amsterdam Cardiovascular Sciences (ACS), Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands, Institute for Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany, Partner site Rhein/Main, German Center for Cardiovascular Research (DZHK), Frankfurt am Main, Germany, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain, Department of Molecular Genetics, Faculty of Science and Engineering, Maastricht University, Maastricht, The Netherlands, Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands, Department of Medicine, Surgery and Dentistry, University of Salerno, Italy, Department of Molecular and Experimental Cardiology, Ruhr University Bochum, Bochum, Germany, Department of Cardiology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany, Department of Cardiology, Maastricht University Medical Centre, University Hospital Maastricht, The Netherlands, Center for Heart Failure Research, Cardiovascular Research Institute Maastricht (CARIM), University Hospital Maastricht, The Netherlands, Department of Translational Medical Sciences and Interdepartmental Center of Clinical and Translational Research (CIRCET), Federico II University, Naples, Italy, Department of Molecular Genetics, Faculty of Science and Engineering; Maastricht University, Maastricht, The Netherlands, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences; Maastricht University, Maastricht, The Netherlands, International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy, School of Cardiovascular Medicine & Sciences, King’s College London, London, UK, Department of Medicine, Surgery and Health Sciences, University of Trieste, Italy, Institute of Pharmacology and Toxicology, Technische Universität München, Biedersteiner Str. 29, Munich 80802, Germany, DZHK (German Center for Cardiovascular Research), Partner site Munich Heart Alliance, Biedersteiner Str. 29, Munich 80802, Germany, Institute for Cardiovascular Regeneration, Goethe University, Germany, German Center for Cardiovascular Research (DZHK), Frankfurt, Germany, Cardio-Pulmonary Institute (CPI), Frankfurt, Germany, Institute of Cardiology, University of Pisa, Pisa, Italy, Department of Internal Medicine, University of Texas Medical School, Houston, TX, USA

Abstract:  Vast parts of mammalian genomes are actively transcribed, predominantly giving rise to non-coding RNA (ncRNA) transcripts including microRNAs, long ncRNAs, and circular RNAs among others. Contrary to previous opinions that most of these RNAs are non-functional molecules, they are now recognized as critical regulators of many physiological and pathological processes including those of the cardiovascular system. The discovery of functional ncRNAs has opened up new research avenues aiming at understanding ncRNA-related disease mechanisms as well as exploiting them as novel therapeutics in cardiovascular therapy. In this review, we give an update on the current progress in ncRNA research, particularly focusing on cardiovascular physiological and disease processes, which are under current investigation at the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart. This includes a range of topics such as extracellular vesicle-mediated communication, neurohormonal regulation, inflammation, cardiac remodelling, cardio-oncology as well as cardiac development and regeneration, collectively highlighting the wide-spread involvement and importance of ncRNAs in the cardiovascular system. 

Retracted: No

PubPeer comments:
 In Figure 3d, the two Tetramer+ flow plots for H25-4 and H25-31 are completely identical even though they are purported to show different cell lines ![file] ,