Physcion 8-O-β-glucopyranoside induced ferroptosis via regulating miR-103a-3p/GLS2 axis in gastric cancer
Authors: Ying Niu
Jinping Zhang
Bingrong Liu
Jiansheng Li
Yalin Tong
Journal: Life Sciences (2019)
Discipline: BIOLOGY & BIOCHEMISTRY
Keywords: Ferroptosis; Gastric cancer; Malignant biological behavior; Physcion 8-O-β-glucopyranoside.
Affiliations: Department of Gastroenterology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Department of Gastroenterology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Electronic address: .

Abstract:  This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of Editor-in-Chief and the authors. The journal was initially contacted by the corresponding author to request the retraction of the article because the author claimed that part of the paper was outsourced to a third-party company who offered them the “wrong picture”. During the investigation, the Editor became aware of allegations about this article on Pubpeer. Figure 7E is similar to Figure 7F from the article published by Xiaoping Pan, Chen Wang, Yan Li, Lida Zhu and Ti Zhang in Life Sciences, 214, (2018) 124-135 https://doi.org/10.1016/j.lfs.2018.10.064, a similar portion of Figure 6D from the article published by Qiang Wang, Yi Yan, Jie Zhang, Peng Guo, Yuqing Xing, Yong Wang, Fawei Qin and Qingyun Zeng in Biomedicine &amp; Pharmacotherapy, 104, (2018) 28-35 https://doi.org/10.1016/j.biopha.2018.05.013, portions of Figure 6C from the article published by Jun Zou, Yamei Wang, Mingdi Liu, Xiushu Huang, Wenjian Zheng, Qian Gao, Haijing Wang in Cell Biochemistry and Function, 36, (2018) 303-311 https://doi.org/10.1002/cbf.3349, portions of Figure 8C from the article published by Kaili Liu, Hui Gao, Qiaoyun Wang , Longyuan Wang, Bin Zhang , Zhiwu Han, Xuehong Chen, Mei Han, and Mingquan Gao in Cancer Science, 109, (2018) 1369-1381 https://doi.org/10.1111/cas.13575, portions of Figure 8D of the article published by Xiangyang Dou, Meihua Wang, Tao Zhang and Jiapei Yao in The Anatomical Record, 303, (2020) 3117-3128 https://doi.org/10.1002/ar.24324, portions of Figure 6F from the article published by Xuezhu Lin, Mingquan Gao, Ailing Zhang, Jingjie Tong, Xiaoyi Zhang, Quanzhong Su, Zhihong Yang, Hui Gao and Guohui Jiang in Life Sciences 239, (2019) 117074 https://doi.org/10.1016/j.lfs.2019.117074, portions of 6F from the article published by Luping Wang, Lu Yun, Xiaojun Wang, Liying Sha, Luning Wang, Yingying Sui and Hui Zhang in Life Sciences, 218, (2019) 16-24 https://doi.org/10.1016/j.lfs.2018.12.023, and portions of Figure 7F from the article published by Dong Li, Xiaoyan Li , Genqu Li , Yan Meng , Yanghong Jin , Shuang Shang , Yanjie Li in Life Sciences, 216, (2019) 259-270 https://doi.org/10.1016/j.lfs.2018.11.032. The journal requested the authors to provide the raw data. However, the authors were not able to fulfill this request and therefore the Editor-in-Chief has decided to retract the article. 

Retracted: Yes

PubPeer comments:
 Here are galleries of histology slices from four papers, with four non-overlapping teams of nominal authors, sharing surprisingly many slices in common. Identication of each slice in terms of treatment and immunohistochemistry stain is arbitrary. There are more duplicates but I lost interest when I ran out of colors. Upper left: Fig 6D from [Wang et al (2018)] . Physcion 8-O-u03b2-glucopyranoside and clear-cell renal cell carcinoma. Middle left: 8D from [Dou et al (2019)] . Physcion 8-O-u03b2-Glucopyranoside and Testicular Germ Cell Tumors. Upper right: 7E from [Niu et al (2019)] . Physcion 8-O-u03b2-glucopyranoside and gastric cancer. Lower: 6C from [Zou et al (2018)] . Euxanthone and epithelial ovarian cancer. ![] , 
 Fig 7E *[right]*. Tissue samples also appear in 8C from [Liu et al (2018)] [left] **AND** in 6C from [Zou et al (2018)] *[bottom]*. Differently identified. No authors in common. ![] , 
 Here are galleries of histology slices from **six** papers, with **six** non-overlapping teams of nominal authors, sharing surprisingly many slices in common. Identication of each slice in terms of treatment and immunohistochemistry stain is arbitrary. Focussing on connections to the uppermost image, due to lack of colors to show other inter-relationships. Clockwise from top: Fig 7F from [Pan et al (2018)] . Physcion and hepatoceullar carcinoma. 7E from [Niu et al (2019)] . Physcion 8-O-u03b2-glucopyranoside and gastric cancer. Fig 6D from [Wang et al (2018)] . Physcion 8-O-u03b2-glucopyranoside and clear-cell renal cell carcinoma. 6C from [Zou et al (2018)] . Euxanthone and epithelial ovarian cancer. 8C from [Liu et al (2018)] . Hispidulin and colorectal cancer. 8D from [Dou et al (2019)] . Physcion 8-O-u03b2-Glucopyranoside and Testicular Germ Cell Tumors. ![] , 
  Fig. 7. **PG** suppresses growth and metastasis of **gastric** cancer. A: The tumor size was obtained from nude mice .  FIGURE 8 In vivo efficacy of **hispidulin** in **colorectal** cancer tumor growth and metastasis. ... B, Reduction in tumor weight by hispidulin treatment . From [Liu et al (2018)] ,  Hispidulin suppresses cell growth and metastasis by targeting PIM1 through JAK2 STAT3 signaling in colorectal cancer . ![file] Who would have thought that gastric and colorectal xenograft cancers would appear so similar? , 
 #4 Hat-tip to [Xylocampa Areola] : ![] , 
 Fig 6E (below) appears to be derived from Fig 3E (above) from [Liu et al. (2018)] : ![file] , 
 *[Below]* Fig 7D.  PG suppresses growth and metastasis of gastric cancer.... D: The apoptotic cells was detected by TUNEL staining . Could the authors comment on the similarity between the results for 25 mg kg day of PG, and for 50 mg kg day of Soy B, in colorectal cancer, as in 6B of [Wang et al (2019)] ? *[Above]* ![file] , 
 Above: Fig 6F from Wang et al (2019),  Soy B did not cause marked histological damage in spleen, liver, heart, kidney and lung tissue. Below: 7H,  HE staining was applied to evaluate the changes in the lung, heart, kidney and liver tissues ![file] , 
 #8 I hope people appreciate the effort put into creating this montage. From top left, clockwise: 6F from [Lin et al (2019)] :  The toxicity of FL118 on the heart, liver, spleen, lung and kidneys were examined using H E staining . 6F [Wang et al (2019)] :  Soy B did not cause marked histological damage in spleen, liver, heart, kidney and lung tissue . 7H [Niu et al (2019)] :  HE staining was applied to evaluate the changes in the lung, heart, kidney and liver tissues . 7F [Li et al (2019)] :  Representative pictures of H E stained tissues of the heart, liver, spleen, lung and kidney of the AIF-treated mice . ![] In the  kidney column for Lin et al, the three panels are in the opposite sequence from the Wang et al and Niu et al kidney columns. To show that would require more colors. , 
 #7 Another appearance of these images in [Pan et al (2019)] . ![] , 
 Retracted [13 July 2022] . ------------------------- This article has been retracted at the request of Editor-in-Chief and the authors. The journal was initially contacted by the corresponding author to request the retraction of the article because the author claimed that part of the paper was outsourced to a third-party company who offered them the u201cwrong pictureu201d. During the investigation, the Editor became aware of allegations about this article on Pubpeer. Figure 7E is similar to Figure 7F from the article published by Xiaoping Pan, Chen Wang, Yan Li, Lida Zhu and Ti Zhang in Life Sciences, 214, (2018) 124-135 https: doi.org 10.1016 j.lfs.2018.10.064, a similar portion of Figure 6D from the article published by Qiang Wang, Yi Yan, Jie Zhang, Peng Guo, Yuqing Xing, Yong Wang, Fawei Qin and Qingyun Zeng in Biomedicine Pharmacotherapy, 104, (2018) 28-35 https: doi.org 10.1016 j.biopha.2018.05.013, portions of Figure 6C from the article published by Jun Zou, Yamei Wang, Mingdi Liu, Xiushu Huang, Wenjian Zheng, Qian Gao, Haijing Wang in Cell Biochemistry and Function, 36, (2018) 303-311 https: doi.org 10.1002 cbf.3349, portions of Figure 8C from the article published by Kaili Liu, Hui Gao, Qiaoyun Wang , Longyuan Wang, Bin Zhang , Zhiwu Han, Xuehong Chen, Mei Han, and Mingquan Gao in Cancer Science, 109, (2018) 1369-1381 https: doi.org 10.1111 cas.13575, portions of Figure 8D of the article published by Xiangyang Dou, Meihua Wang, Tao Zhang and Jiapei Yao in The Anatomical Record, 303, (2020) 3117-3128 https: doi.org 10.1002 ar.24324, portions of Figure 6F from the article published by Xuezhu Lin, Mingquan Gao, Ailing Zhang, Jingjie Tong, Xiaoyi Zhang, Quanzhong Su, Zhihong Yang, Hui Gao and Guohui Jiang in Life Sciences 239, (2019) 117074 https: doi.org 10.1016 j.lfs.2019.117074, portions of 6F from the article published by Luping Wang, Lu Yun, Xiaojun Wang, Liying Sha, Luning Wang, Yingying Sui and Hui Zhang in Life Sciences, 218, (2019) 16-24 https: doi.org 10.1016 j.lfs.2018.12.023, and portions of Figure 7F from the article published by Dong Li, Xiaoyan Li , Genqu Li , Yan Meng , Yanghong Jin , Shuang Shang , Yanjie Li in Life Sciences, 216, (2019) 259-270 https: doi.org 10.1016 j.lfs.2018.11.032. The journal requested the authors to provide the raw data. However, the authors were not able to fulfill this request and therefore the Editor-in-Chief has decided to retract the article. --------------------- Cited 64 times, by Google Scholar s count. ,