A New Ni(II)-Containing Coordination Complex Based on the Multiple N-Donor Ligand: Crystal Structure and Application of its Nanoparticle as a P. gingivalis Biofilm Inhibitor for Periodontitis Treatment
Authors: Zhao, J.-J.
Hu, Y.-T.
Dai, Y.
Gan, J.-C.
Journal: Journal of Structural Chemistry (2020)
Discipline: CHEMISTRY
Keywords: solvothermal reaction; Ni(II)-containing coordination complex; nanoparticles; antibiofilm activity; P. gingivalis

Abstract: A solvothermal reaction of Ni(NO3)2·6H2O, the multiple N-donor ligand 6,6′-bis (1H-benzo[d]imidazol-2-yl)-2,2′-bipyridine (H2L), in a mixed solvent of DMF and water give rise to a new Ni(II)-containing coordination complex with the chemical formula [Ni(HCOO) (HL)(H2O)] (1). The chemical composition of as-prepared complex 1 is determined via the elemental analysis and the structural arrangement is probed via single crystal X-ray diffraction. Furthermore, we use the grinding method to prepare nanoparticles of complex 1 with an average size of 89 nm. To overcome the difficulty of P. gingivalis infected periodontal diseases, the antibiofilm activity of nano 1 is evaluated by the crystal violet staining assay, and the RT-PCR measurement is performed to detect the activity of nano 1 on reducing hagB and hagC genes expression.

Retracted: No

PubPeer comments:
 References seem to be taken from a template rather than chosen for their relevance to the in-text citations. See e.g. [Wu Lian (2020)] .  Transition metal complexes of multidentate heterocyclic ligands containing nitrogen donor sites have gained prominence due to their versatile structural features, varied ligational behavior, beneficial biological activities, and potential applications in the fields of medicine, materials research and catalysis [6-9]. - [6]. C. Duan, F. Li, M. Yang, H. Zhang, Y. Wu, and H. Xi. Ind. Eng. Chem. Res., 2018, 57, 15385. * Rapid synthesis of hierarchically structured multifunctional metalu2013organic zeolites with enhanced volatile organic compounds adsorption capacity * - [7]. L. Niu, J. L. Xu, W. L. Yang, C. H. Kang, J. Q. Ma, and J. Q. Su. Sci. Adv. Mater., 2019, 11, 466. ** Synergistic Effect Between Nano-Sb2O3 and Brominated Epoxy Resin on the Flame Retardancy of Poly(butylene terephthalate) ** - [8]. Y. Y. Yang, L. Kang, and H. Li. Ceram. Int., 2019, 45, 8017. ** Enhancement of photocatalytic hydrogen production of BiFeO3 by Gd3+ doping ** - [9]. H. Zhao, X. Mu, C. Zheng, S. Liu, Y. Zhu, X. Gao, and T. Wu. J. Hazard. Mater., 2019, 366, 240. ** Structural defects in 2D MoS2 nanosheets and their roles in the adsorption of airborne elemental mercury **  Metal complexes, particularly those containing sp2 hybrid nitrogen atoms as a part of the aromatic system of ligands, find significant applications as drugs [10]. - [10]. H. Du, C. Ma, W. Ma, and H. Wang. Process. Appl. Ceram., 2018, 12, 303. ** Microstructure evolution and dielectric properties of Ce-doped SrBi4Ti4O15 ceramics synthesized via glycine-nitrate process ** Several derivatives of bipyridine and imidazole were reported to exhibit a wide range of pharmacological activities such as antimicrobial, anti-inflammatory, antidiabetic, antitumour, and antidepressant, in addition to their use in catalysis and organic synthesis [11-13]. - [11]. H. Zhang and Y. Fang. J. Alloy. Comp., 2019, 781, 201. ** Temperature dependent photoluminescence of surfactant assisted electrochemically synthesized ZnSe nanostructures ** , 
 This is one of a large number of coordination-chemistry papers that appear to have all been written according to a template. - All draw on the same small pool of papers to illustrate the broad range of applications and properties of MOFs. Even when the in-text citations match the references, one might expect independent authors to think of different examples. - Many cite Zhao, Kang and Yao (2019) -- **Research and Application of Acoustic Emission Signal Processing Technology** -- which is completely irrelevant to the topic, but became part of the template anyway. - The vast majority of email identities for corresponding authors were formed by taking an underscore-separated name and appending 666 or 66 . I am advised that these are auspicious numbers with positive associations. So one possibility is that the authors all decided independently to generate email accounts with this format. The alternative is that *some outside contractor* handled the task of negotiating with journals (generating these disposable accounts in the process) - perhaps also the task of writing the manuscripts, using a single Bibliography file to save time. For a (partial) list [see here] . In the following, (some of) the recurring References are labelled 1 to 14 . Searching for other papers that cite them might be informative. ------------------------------ - [1]. D. M. Chen, J. Y. Tian, Z. W. Wang, C. S. Liu, M. Chen, and M. Du (2017). Chem. Commun. 53, 10668.  An anionic Na(i)u2013organic framework platform: separation of organic dyes and post-modification for highly sensitive detection of picric acid - [2]. H. Du, C. Ma, W. Ma, and H. Wang. Process. Appl. Ceram., 2018, 12, 303  Microstructure evolution and dielectric properties of Ce-doped SrBi4Ti4O15 ceramics synthesized via glycine-nitrate process - [3]. C. Duan, J. Huo, F. Li, M. Yang, H. Xi, J. Mater. Sci. 53 (2018) 16276.  Ultrafast room-temperature synthesis of hierarchically porous metalu2013organic frameworks by a versatile cooperative template strategy - [4]. C. Duan, F. Li, M. Yang, H. Zhang, Y. Wu and H. Xi, Rapid Synthesis of Hierarchically Structured Multifunctional Metalu2013Organic Zeolites with Enhanced Volatile Organic Compounds Adsorption Capacity, Ind Eng Chem Res 57 (2018), 15385u201315394. - [5]. C. Duan, H. Zhang, F. Li, J. Xiao, S. Luo, and H. Xi. Soft Matter, 2018, 14, 9589.  Hierarchically porous metalu2013organic frameworks: rapid synthesis and enhanced gas storage - [6]. Y. Feng, M. Li, H. Fan, Q. Huang, D. Qiu, and H. Shi (2015). Dalton Trans. 44, 894.  A novel open-framework copper borophosphate containing 1-D borophosphate anion with 10-MR windows and 12-MR channels - [7]. L. Kang, H.L. Du, X. Du, H.T. Wang, W.L. Ma, M.L. Wang and F.B. Zhang, Study on dye wastewater treatment of tunable conductivity solid-waste-based composite cementitious material catalyst, Desalin Water Treat 125 (2018), 296u2013301. - [8]. L. Kang, L. Zhao, S. Yao, C. Duan, Ceram. Int. 45 (2019) 16717.  A new architecture of super-hydrophilic u03b2-SiAlON graphene oxide ceramic membrane for enhanced anti-fouling and separation of water oil emulsion - [9]. L. Niu, J. L. Xu, W. L. Yang, C. H. Kang, J. Q. Ma, and J. Q. Su. Sci. Adv. Mater., 2019, 11, 466.  Synergistic Effect Between Nano-Sb2O3 and Brominated Epoxy Resin on the Flame Retardancy of Poly(butylene terephthalate) - [10]. Y.Y. Yang, L. Kang, H. Li, Ceram. Int. 45 (2019) 8017.  Enhancement of photocatalytic hydrogen production of BiFeO3 by Gd3+ doping - [11]. Y. Yang, H. Li, W. Zheng, Y. Bai, Z. Liu, J. Zhang, Sci. Adv. Mater. 11 (2019) 208.  Experimental study on calcining process of secondary coated ceramsite solidified chromium contaminated soil - [12]. L. Zhao, L. Kang, and S. Yao (2019). IEEE Access 7, 984.  Research and Application of Acoustic Emission Signal Processing Technology - [13]. H. Zhao, X. Mu, C. Zheng, S. Liu, Y. Zhu, X. Gao, T. Wu, Structural defects in 2D MoS2 nanosheets and their roles in the adsorption of airborne elemental mercury, J. Hazard Mater. 366 (2019) 240u2013249. - [14]. Y. Feng, H. Fan, Z. Zhong, H. Wang and D. Qiu, Cd3(MoO4)(TeO3)2: A Polar 3D Compound Containing d10u2013d0 SCALP-Effect Cations, Inorg Chem 55 (2016), 11987u201311992. ,