RETRACTED ARTICLE: Decreased miR-154 expression and its clinical significance in human colorectal cancer
Authors: Yang Kai
Cheng Qiang
Lin Kuailu
Zhou Miaomiao
Pan Xinxin
Journal: World Journal of Surgical Oncology (2015)
Discipline: CLINICAL MEDICINE
Keywords: miRNA-154; tumor suppressor; colorectal cancer; clinicopathologic features; prognosis
Affiliations: Department of Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, 325000, China., Department of neurology, Huai'an No. 2 Hospital, Huai'an, Jiangsu Province, China., Department of Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, 325000, China. .

Abstract:  Background: miRNA-154 (miR-154) has been identified as a tumor suppressor in several types of human cancers. However, its clinical significance in colorectal cancer (CRC) is still unclear. The aim of this study was to analyze the association of miR-154 expression with clinicopathologic features and prognosis in CRC patients. Methods: Quantitative RT-PCR was performed to evaluate miR-154 levels in 169 pairs of CRC specimens and adjacent noncancerous tissues. Then, the associations of miR-154 expression with clinicopathological factors or survival of patients suffering CRC were determined. Results: The expression levels of miR-154 in CRC tissues were significantly lower than those in corresponding noncancerous tissues (P &lt; 0.001). Decreased miR-154 expression was significantly associated with large tumor size, positive lymph node metastasis, and advanced clinical stage. Moreover, the univariate analysis demonstrated that CRC patients with low miR-154 expression had poorer overall survival (P = 0.006). The multivariate analysis identified low miR-154 expression as an independent predictor of poor survival. Conclusions: These findings suggested that miR-154 downregulation may be associated with tumor progression of CRC, and that this miR may be an independent prognostic marker for CRC patients. 

Retracted: Yes

PubPeer comments:
 Retracted [14 June 2019] . ---------------------------------- The Editor-in-Chief is retracting this article [1] due to overlap with the following articles (amongst others) [2u20136]. None of the authors have responded to any correspondence from the Editor-in-Chief or publisher about this retraction. References - (1). Kai Y, Qiang C, Xinxin P, Miaomiao Z, Kuailu L. [Decreased miR-154 expression and its clinical significance in human colorectal cancer. World J Surg Oncol. 2015;13:195. doi: 10.1186 s12957-015-0607-5. **Retracted** - (2). Zhu, et al. [Decreased microRNA-224 and its clinical significance in non-small cell lung cancer patients] . Diagn Pathol. 2014;(9):198 http: diagnosticpathology.biomedcentral.com articles 10.1186 s13000-014-0198-4. [**Expression of Concern**] - (3). Fo, et al. [MiR-206 functions as a tumor suppressor and directly targets K-Ras in human oral squamous cell carcinoma] . OncoTargets and Therapy. 2014;7 https: www.dovepress.com front_end mir-206-functions-as-a-tumor-suppressor-and-directly-targets-k-ras-in%2D%2Dpeer-reviewed-article-OTT. [**Retracted**] - (4). Tang M, et al. [MicroRNA-145 downregulation associates with advanced tumor progression and poor prognosis in patients suffering osteosarcoma] . OncoTargets Therapy. 2013;6:833u2013838. - (5). Ye Jun, Wu Xianguo, Wu Dang, Wu Pin, Ni Chao, Zhang Zhigang, Chen Zhigang, Qiu Fuming, Xu Jinghong, Huang Jian. miRNA-27b Targets Vascular Endothelial Growth Factor C to Inhibit Tumor Progression and Angiogenesis in Colorectal Cancer. PLoS ONE. 2013;8(4):e60687. doi: 10.1371 journal.pone.0060687. - (6). Sun, et al. The microRNA-217 functions as a tumor suppressor and is frequently downregulated in human osteosarcoma. Biomed Pharmacother. 2015;71:58u201363. doi: 10.1016 j.biopha.2015.02.014. ------------------------------------------------- Some of this series of retractions was [covered by RetractionWatch] . A broader context is available from [a Chinese science-integrity enthusiast] , blogging in 2016 and citing work by the now-vanished site PlagiarismWatch, to reconstruct a network of **11** mutually-plagiarised papers. All presumably the work of a papermill. ![] ,