Identification of a new orthonairovirus associated with human febrile illness in China
Authors: Li-Xin Ma
Xiao-Long Lv
Shu-Zheng Han
Ying-Hua Zhao
He-Ting Sun
Jun Ma
Wei Wang
Liyan Sui
Quan Liu
Lin-Na Liu
Jun Qian
Chen Chen
Liang Li
Zheng-Lei Cheng
Jian-Wei Shao
Ze-Dong Wang
Xu Zhang
Journal: Nature Medicine (2021)
Discipline: MOLECULAR BIOLOGY & GENETICS
Keywords: Orthonairovirus; Nairoviridae; tick-transmitted pathogens; Songling virus; genomic
Affiliations: School of Life Sciences and Engineering, Foshan University, Foshan, Guangdong Province, China., Military Veterinary Institute, Academy of Military Medical Sciences, Changchun, Jilin Province, China., Second Affiliated Hospital of Inner Mongolia University for the Nationalities, Inner Mongolia General Forestry Hospital, Yakeshi, Inner Mongolia Autonomous Region, China., The First Hospital of Jilin University, Changchun, Jilin Province, China., State Forestry and Grassland Administration, Shenyang, Liaoning Province, China., Alongshan Forestry Bureau, Yakeshi, Inner Mongolia Autonomous Region, China., Alongshan Forest Pest Control Station, Yakeshi, Inner Mongolia Autonomous Region, China., Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China., Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, China. ., Second Affiliated Hospital of Inner Mongolia University for the Nationalities, Inner Mongolia General Forestry Hospital, Yakeshi, Inner Mongolia Autonomous Region, China. ., School of Life Sciences and Engineering, Foshan University, Foshan, Guangdong Province, China. ., Military Veterinary Institute, Academy of Military Medical Sciences, Changchun, Jilin Province, China. ., The First Hospital of Jilin University, Changchun, Jilin Province, China. .

Abstract:  The genus Orthonairovirus, which is part of the family Nairoviridae, includes the important tick-transmitted pathogens Crimean-Congo hemorrhagic fever virus and Nairobi sheep disease virus, as well as many other poorly characterized viruses found in ticks, birds and mammals1,2. In this study, we identified a new orthonairovirus, Songling virus (SGLV), from patients who reported being bitten by ticks in Heilongjiang Province in northeastern China. SGLV shared similar genomic and morphological features with orthonairoviruses and phylogenetically formed a unique clade in Tamdy orthonairovirus of the Nairoviridae family. The isolated SGLV induced cytopathic effects in human hepatoma cells in vitro. SGLV infection was confirmed in 42 hospitalized patients analyzed between 2017 and 2018, with the main clinical manifestations being headache, fever, depression, fatigue and dizziness. More than two-thirds (69%) of patients generated virus-specific antibody responses in the acute phase. Taken together, these results suggest that this newly discovered orthonairovirus is associated with human febrile illness in China. 

Retracted: No

PubPeer comments:
 Duplicate figures were used for two discoveries in China: SGLV AND  TcTV-2 !!! Nat Med. 2021 Feb 18. doi: 10.1038 s41591-020-01228-y. Identification of a new orthonairovirus associated with human febrile illness in China Jun Ma # 1 2, Xiao-Long Lv # 3, Xu Zhang # 1, Shu-Zheng Han # 3, Ze-Dong Wang # 4, Liang Li 2, He-Ting Sun 5, Li-Xin Ma 6, Zheng-Lei Cheng 7, Jian-Wei Shao 1, Chen Chen 4, Ying-Hua Zhao 4, Liyan Sui 4, Lin-Na Liu 8, Jun Qian 9, Wei Wang 10, Quan Liu 11 12 13 Dong Z, Yang M, Wang Z, Zhao S, Xie S, Yang Y, et al. Human Tacheng Tick Virus 2 Infection, China, 2019. Emerg Infect Dis. 2021;27(2):594-598. https: dx.doi.org 10.3201 eid2702.191486 ![file] ![file] , 
 #1 ![file] Thank you very much for your comment, The negative-stain electron micrograph of SGLV (Figure 1f) in our recent paper accepted by NM (NMED-L107436B: Identification of a new nairovirus associated with human febrile illness in China) have been misused. we have contacted the editor and revised the mistakes. Thank again. Quan Liu ,