Natural product inspired allicin analogs as novel anti-cancer agents
Authors: Parimal Karmakar
Kunal Pal
Utsab Debnath
Anup Kumar Misra
Ishani Bhaumik
Kuladip Jana
Journal: Bioorganic Chemistry (2019)
Discipline: BIOLOGY & BIOCHEMISTRY
Keywords: Allicin, garlic; Anti-cancer; Apoptosis; Caspase 3; ROS
Affiliations: Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII M, Kolkata 700054, India., Department of Life Science and Biotechnology, Jadavpur University, Kolkata 700 032, India., Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII M, Kolkata 700054, India. Electronic address: .

Abstract:  A series of novel analogs of Allicin (S-allyl prop-2-ene-1-sulfinothioate) present in garlic has been synthesized in high yield. Synthesized 23 compounds were evaluated against different breast cancer cells (MDA-MB-468 and MCF-7) and non-cancer cells (WI38). Four compounds (3f, 3h, 3m and 3u) showed significant cytotoxicity against cancer cells whereas nontoxic to the normal cells. Based on the LD50 values and selectivity index (SI), compound 3h (S-p-methoxybenzyl (p-methoxyphenyl)methanesulfinothioate) was considered as most promising anticancer agent amongst the above three compounds. Further bio-chemical studies confirmed that compound 3h promotes ROS generation, changes in mitochondrial permeability transition and induced caspase mediated DNA damage and apoptosis. 

Retracted: No

PubPeer comments:
 ![file] **bcl2 of fig 7a and b is same blot but author mention that they are from different cell type e.g. MDA-MB-468 and MCF7** **Further cleaved caspase 3 blot of fig 7a is the copy of p27 blot of previously published paper** (Pal K, Laha D, Parida PK, et al. An In Vivo Study for Targeted Delivery of Curcumin in Human Triple Negative Breast Carcinoma Cells Using Biocompatible PLGA Microspheres Conjugated with Folic Acid. J Nanosci Nanotechnol. 2019;19(7):3720-3733. doi:10.1166 jnn.2019.16292) ![file] , 
 ![file] further cleaved caspase 3 blot of fig 7a is the copy of p27 blot and reverse of p-akt of previously published paper (Pal K, Laha D, Parida PK, et al. An In Vivo Study for Targeted Delivery of Curcumin in Human Triple Negative Breast Carcinoma Cells Using Biocompatible PLGA Microspheres Conjugated with Folic Acid. J Nanosci Nanotechnol. 2019;19(7):3720-3733. doi:10.1166 jnn.2019.16292) ![file] , 
 In the erratum of their paper author again **duplicate the western blot picture**. Here author uses the cleaved caspase 3 blot of  Pal K, Laha D, Parida PK, et al. An In Vivo Study for Targeted Delivery of Curcumin in Human Triple Negative Breast Carcinoma Cells Using Biocompatible PLGA Microspheres Conjugated with Folic Acid. J Nanosci Nanotechnol. 2019;19(7):3720-3733. doi:10.1166 jnn.2019.16292 to the erratum of current paper Corrigendum to u201cNatural product inspired allicin analogs as novel anti-cancer agentsu201d [Bioorg. Chem. 86 (2019) 259u2013272]![file] , 
 ![file]  Natural product inspired allicin analogs as novel anti-cancer agents https: doi.org 10.1016 j.bioorg.2019.01.057 Fig. 6 The marked pictures have been found to be similar. It seems that the first picture has been enlarged and cropped and reported below. ,