Protective autophagy induced by physcion suppresses hepatocellular carcinoma cell metastasis by inactivating the JAK2/STAT3 Axis
Authors: Ti Zhang
Lida Zhu
Yan Li
Chen Wang
Xiaoping Pan
Journal: Life Sciences (2018)
Discipline: BIOLOGY & BIOCHEMISTRY
Keywords: Apoptosis; HCC; Metastasis; Physcion; Protective autophagy.
Affiliations: Tianjin Medical University Cancer Institute and Hospital, National Clinical Research for Cancer, Tianjin, China; The People's Hospital of Wuhai, Inner Mongolia, China., The People's Hospital of Wuhai, Inner Mongolia, China., Tianjin Medical University Cancer Institute and Hospital, National Clinical Research for Cancer, Tianjin, China; Key Laboratory of Cancer Prevention and Therapy, Tianjin, China; Tianjin's Clinical Research for Cancer, Tianjin, China. Electronic address: .

Abstract:  This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief and the authors, as panels from Figure 6F appear as similar to panels from Figure 2B of the article published by Ming-Quan Gao, Hui Gao, Mei Han, Kai-Li Liu, Jian-Jun Peng and Yan-Tao Han in the American Journal of Cancer Research 7 (2017) 1501–1514 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523031/ and Figures 2E and 3E of the article published by Meizhi Wang, Hui Gao, Haijun Qu, Jing Li, Kaili Liu and Zhiwu Han in Pharmacological Reports 70 (2018) 963–971 https://doi.org/10.1016/j.pharep.2018.04.006. Also, the Vehicle panel from Figure 7E appears as similar to the Vehicle panel from Figure 3D of the article published by Bo Liu and Shuo Yu in Biomedicine &amp; Pharmacotherapy 107 (2018) 243–253 https://doi.org/10.1016/j.biopha.2018.07.177. Figure 7E appears also as similar to Figure 6(b) of the article published by Mei Han, Hui Gao, Jing Xie, Yin-ping Yuan, Quan Yuan, Ming-quan Gao, Kai-li Liu, Xue-hong Chen, Yan-tao Han and Zhi-wu Han in Acta Pharmacologica Sinica volume 40 (2019) 666–676 https://doi.org/10.1038/s41401-018-0159-7. Moreover, panels from Figure 7F appear as similar to panels from Figure 7E of the Reference [1], Figure 6D of the Reference [2], Figure 6C of the Reference [3], Figure 8C of the Reference [4], Figure 8D of the Reference [5] and Figure 6B of the Reference [6]. One of the conditions of submission of a paper for publication is that authors declare explicitly that their work is original and has not appeared in a publication elsewhere. Re-use of any data should be appropriately cited. As such this article represents a severe abuse of the scientific publishing system. The scientific community takes a very strong view on this matter and apologies are offered to readers of the journal that this was not detected during the submission process. 

Retracted: Yes

PubPeer comments:
 [Top]  Fig. 4 G648C mutation enhanced the proliferation inhibition effect of chemotherapeutic agents in vivo. a The bioluminescence signal of the G648C group cells was relatively weaker than WT and polu03b2u2212 u2212 groups after treating with 5-FU. b The bioluminescence signal of the G648C group cells was relatively weaker than WT and polu03b2u2212 u2212 groups after treating with cisplatin. Also shown horizontally flipped, for ease of comparison. [Middle]:  Fig. 2 Upregulated miR-198 inhibited cell proliferation in lung adenocarcinoma in vitro and in vivo.... e, f The luciferase signal was clearly lower in the miR-198 nude mice than in the control groups at 2, 3, and 4 weeks . From  miR-198 targets SHMT1 to inhibit cell proliferation and enhance cell apoptosis in lung adenocarcinoma [(Wu et al 2016)] . [Bottom] :Fig 2D  The bioluminescence signal was relatively weaker in the miR-499 group than in the NC and Blank groups. From  MiR-499 Enhances the Cisplatin Sensitivity of Esophageal Carcinoma Cell Lines by Targeting DNA Polymerase u03b2 [(Wang et al 2015)] . Stars mark the mice shown in more than one treatment group. ![file] , 
 [Perhaps a systemic problem] . Journals and readers may wish to proceed with caution. ,