The molecular mechanism of serum microRNA124b induced coronary heart disease by inducing myocardial cell senescence
Authors: Q-J Qin
Y-Q Weng
Z-M Ge
Y-N Wang
M-L Guo
Y-B Wang
L-L Guo
J Yao
X-Z Zhang
Journal: European review for medical and pharmacological sciences (2018)
Discipline: PHARMACOLOGY & TOXICOLOGY
Keywords: coronary heart disease; microRNA124b; cell senescence; myocardial cell dysfunction; heart function
Affiliations: Department of Cardiology, Qilu Hospital of Shandong University, Jinan, Shandong, China. .

Abstract:  Objective: The incidence and mortality of coronary heart disease are rapidly increasing in recent years. Myocardial cell dysfunction and cell senescence may play a role in coronary heart disease. MicroRNA controls a variety of biological processes, but leaving its role in coronary heart disease has yet to be explored. Patients and methods: Patients with coronary heart disease were regarded as subjects, and healthy volunteers as the control, on both of which microRNA124b level of serum was studied by Real-time PCR, and the heart function of patients was detected by using ultrasound. The relationship between serum microRNA124b level and cardiac function was analyzed along with the model of rat coronary artery disease; the level of aging proteins P21 and P53 in cardiac muscle cells was also tested. Results: MicroRNA124b in the serum of patients with coronary heart disease was increased, and the heart function of patients was decreased (p &lt; 0.05). Serum level of microRNA124b in a rat model of coronary heart disease was increased, and the cardiac function was decreased (p &lt; 0.05). When myocardial cell appeared ageing, the level of P21 and P53 was increased, and the level of microRNA124b was related with P53. Conclusions: The level of microRNA124b in the serum of coronary heart disease patients and rat model may be related to the occurrence of coronary heart disease; microRNA124b may lead to the occurrence of coronary heart disease by causing cell senescence. 

Retracted: Yes

PubPeer comments:
 This article was reviewed on the error bar podcast episode 1: https: theerrorbar.com ?e=1. The review was done in the light of newspaper headlines about the article. The slightly-edited transcript is copied here: headline: URBAN LANDSCAPES SLOW YOU DOWN tweet: looking at pictures of urban scenes while you walk slows you down by about 1 meter per minute relative to rural scenes. but a blank scene speeds you up three times as much description: in a long room with a large video screen at one end, 20 adults were asked to walk over a 10 metre course while looking at a picture. they did this 105 times - once each for 100 scenes - 50 urban and 50 rural - as well as 5 times with a blank grey scene. the researchers recorded the positions of various parts of the volunteers bodies - ankles, knees, and hips, and measured walking speed, step length, step time and leg swing time. they found that when watching the urban scenes, people walked slowest - at 2.88 miles per hour while rural scenes were walked towards at 2.91 mph. the results are interpreted in terms of the visual stress or distraction of looking at urban landscapes. evaluation: while the slowest walking was indeed produced by the urban scenes, this was only very slightly slower than the rural scenes - by 0.03 miles per hour, or a difference of only 60 metres after walking for a whole hour. is this a big difference? not really. is it a statistically reliable difference? yes - the data and the analysis were powerful enough to find statistical differences, but these differences were not as strong as the control study reported in the supplementary materials, in which the volunteers walked along while doing some cognitively demanding stuff. most importantly, while the differences between urban and rural scenes were rather small, the differences between either of those conditions and a blank grey scene were much larger. walking towards neutral grey images was 0.1 mph faster than towards a rural scene - that s 150 meters extra per hour. conclusion: watching cityscapes may slow you down a bit, but watching a blank screen really puts a spring in your step ,