RETRACTED: Up-regulation of ANXA1 suppresses polymorphonuclear neutrophil infiltration and myeloperoxidase activity by activating STAT3 signaling pathway in rat models of myocardial ischemia-reperfusion injury
Authors: Yongliang Wang
Jing Jiang
Beibei Zhang
Yongquan Wu
Can Zhao
Journal: Cellular Signalling (2019)
Discipline: MOLECULAR BIOLOGY & GENETICS
Keywords: ANXA1; Inflammation; Myeloperoxidase activity; Myocardial ischemia-reperfusion injury; Polymorphonuclear neutrophil infiltration

Abstract:  This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief and authors. The authors reported that the paper had been submitted without permission of all authors (specifically Professor Wu). When asked to respond to alleged image manipulation by ‘Hoya camphorifolia’ in Fig. 8B and western blots, they responded that they regret the mistakes in figure 8B and that their technical collaborators could not provide the original images of the Western blots in this paper. The authors apologise for any misconceptions that this paper may have resulted in. 

Retracted: Yes

PubPeer comments:
 Fig 8B.  HE staining of PMN infiltration. Overlap marked. ![file] , 
 Here is a montage of curious Western Blots I collected, representing a distinct style. They are marked by high contrast and an absence of any background texture, and resemble ink blobs. They are not always sharp-edged; sometimes the ink appears to have spread, creating filaments. When there are double bands (ERK 1 2, JNK 1 2, LC3 I II, the sub-bands are somehow decoupled: differing in overall profile and in the width of the protein blobs, and with horizontal displacements, almost falling into different lanes. The papers that contain them tend to be problematic in other ways (some have been retracted). Their manifestations began in 2019 papers, and stopped in 2020 as if their use became deprecated. ![] Sources include - [He et al (2020)] - [Chang et al (2020)] - [Shang et al (2020)] - [Shi et al (2019)] *[RETRACTED]* - [Xu et al (2019)] *[RETRACTED]* - [Jia et al (2020)] - [Feng et al (2019)] Examples could be multiplied but I will settle for three more examples, to show the range of this gamut, from - [Qu et al (2019)] *[RETRACTED]* - [Song et al (2019)] *[RETRACTED]* - [Shi et al (2019)] . ![file] ---------------------------------------------- Here are the present 2E, 10B E:  , the protein expression of ANXA1, STAT3, VEGF, and the extent of STAT3 phosphorylation in MIRI rats and sham-operated rats examined by western blot analysis ... the protein expression of ANXA1, STAT3, VEGF, and the extent of STAT3 phosphorylation in myocardial tissues measured by western blot analysis ... the protein expression of STAT5 and STAT6 in myocardial tissues measured by western blot analysis . They appear to be manifestations of the same style. Is it possible for the authors to upload or link to scans of the original blots, to allay any concerns? ![file] , 
 Retracted [24 March 2022] . ---------------------- This article has been retracted at the request of the Editor-in-Chief and authors. The authors reported that the paper had been submitted without permission of all authors (specifically Professor Wu). When asked to respond to alleged image manipulation by u2018Hoya camphorifoliau2019 in Fig. 8B and western blots, they responded that they regret the mistakes in figure 8B and that their technical collaborators could not provide the original images of the Western blots in this paper. The authors apologise for any misconceptions that this paper may have resulted in. ,