Potential clinical applications of the personalized, disease-specific protein corona on nanoparticles
Authors: José Manuel Cameselle-Teijeiro
Cristina Núñez
Susana B Bravo
Sergio Vázquez-Estévez
María García Vence
María Del Pilar Chantada-Vázquez
Journal: Clinica Chimica Acta (2020)
Discipline: CLINICAL MEDICINE
Keywords: Diagnosis; Disease; Nanoparticles; Protein corona; Therapy.
Affiliations: Proteomic Unit, Instituto de Investigaciones Sanitarias-IDIS, Complejo Hospitalario Universitario de Santiago de Compostela (CHUS), 15706 Santiago de Compostela, Spain., Research Unit, Hospital Universitario Lucus Augusti (HULA), Servizo Galego de Saúde (SERGAS), 27002 Lugo, Spain., Oncology Division, Hospital Universitario Lucus Augusti (HULA), Servizo Galego de Saúde (SERGAS), 27002 Lugo, Spain., Department of Anatomic Pathology, Clinical University Hospital, School of Medicine, Galician Healthcare Service (SERGAS), University of Santiago de Compostela, Santiago de Compostela, Spain., Research Unit, Hospital Universitario Lucus Augusti (HULA), Servizo Galego de Saúde (SERGAS), 27002 Lugo, Spain. Electronic address: .

Abstract:  Nanoscale objects lose their original identity once in contact with biological fluids and get a new biological identity, referred to as a protein corona (PC). The PC modifies many of the physicochemical properties of nanoparticles (NPs), including surface charge, size, and aggregation state. These changes, in turn, affect the biological fate of NPs, including their biodistribution, pharmacokinetics, and therapeutic efficacy. It is well known that even small differences in the composition of a protein source (e.g., plasma and serum) can considerably change the composition of the corona formed on the surface of the same NPs. Recently, it has been shown that the PC is intensely affected by the patient's specific disease. Consequently, the same nanomaterial incubated with proteins of biological fluids belonging to patients with different pathologies adsorbs protein coronas with different compositions, giving rise to the concept of the personalized protein corona (PPC). Herein, we review recent advances on the topic of PPC, with a particular focus on their clinical significance. 

Retracted: No

PubPeer comments:
  Coordination polymers (CPs) have special structures and topological properties, as well as potential applications in gas preservation, catalysis, magnetism and sensing [5u20139]. For the purposes of the present literature,  coordination polymer can include purely inorganic catalysts and coatings. - [5] D. Yuan, M. Sun, M. Zhao, S. Tang, J. Qi, X. Zhang, K. Wang, B. Li, Int. J. Electrochem. Sci., 15, 8761 (2020). ** Persulfate Promoted ZnIn2S4 Visible Light Photocatalytic Dye Decomposition ** - [6] N. Jiang, Y. Liu, X.N. Yu, H.B. Zhang, M.M. Wang, Int. J. Electrochem. Sci., 15, 5520 (2020). ** Corrosion Resistance of Nickel-Phosphorus Nano-ZnO Composite Multilayer Coating Electrodeposited on Carbon Steel in Acidic Chloride Environments ** Even aluminium nanocomposites!  According to previous studies, the selection of appropriate bridging ligands and metals can create a specific structure and even make CPs have pre-designed functions [10u201312]. - [10] C. Duan, Z. Su, Y. Cao, L. Hu, D. Fu, J. Ma, Y. Zhang. J. Clean. Prod., 283, 124635 (2021) ** Synthesis of core-shell u03b1-AlH3@Al(OH)3 nanocomposite with improved low-temperature dehydriding properties by mechanochemical mixing and ionic liquid treatment ** ,