Atorvastatin improves cardiac function of rats with chronic cardiac failure via inhibiting Rac1/P47phox/P67phox-mediated ROS release
Authors: S-K An
H-A Wu
S-Y Fu
X-H Wei
L-P An
Journal: European review for medical and pharmacological sciences (2015)
Discipline: PHARMACOLOGY & TOXICOLOGY
Keywords: Atorvastatin; Isoproterenol; Chronic heart failure; Rac1; p47phox
Affiliations: Department of Cardiology, Heilongjiang Provincial Hospital, Harbin, China. .

Abstract:  Objective: To discuss the protective mechanisms of atorvastatin treatment for isoproterenol (ISO)-induced chronic heart failure. Materials and methods: The rats were randomly divided into three groups: normal group (n = 15, age-matched normal adult rats), ISO group (n = 11, ISO induced heart failure) and atorvastatin group (n = 14, ISO induced lesion but received atorvastatin treatment). The cardiac function was evaluated by echocardiography and hemodynamics analysis. In addition, the Rac1 activity in the myocardium and the expression levels of Rac1, p47phox and p67phox were measured by RT-PCR and western blot. Results: Rats in ISO group developed into heart failure with decreased cardiac function. The Rac1, p47phox and p67phox mRNA expressions and ROS release were increased in ISO group. Atorvastatin treatment improved cardiac function of rats with isoproterenol-induced chronic heart failure and decreased the Rac1, p47phox and p67phox mRNA expressions. Also, membrane protein expression of Rac1 and ROS release decreased significantly. Conclusions: Atorvastatin may improve cardiac function of rats with heart failure via inhibiting Rac1/P47phox/P67phox-mediated ROS release. 

Retracted: No

PubPeer comments:
  A variety of powerful CPs has been reported, such as unidimensional chains and ladders, 2-dimension grids, 3-dimension microporous frameworks, interpenetrated patterns, and spiral staircase frameworks [4u20137] For the purposes of this *oeuvre*,  coordination polymer* can include inorganic catalysts and coatings. - [5]. D. Yuan, M. Sun, M. Zhao, S. Tang, J. Qi, X. Zhang, K. Wang, and B. Li (2020). Int. J. Electrochem. Sci. 15, 8761. ** Persulfate Promoted ZnIn2S4 Visible Light Photocatalytic Dye Decomposition ** - [6]. N. Jiang, Y. Liu, X. N. Yu, H. B. Zhang, and M. M. Wang (2020). Int. J. Electrochem. Sci. 15, 5520. ** Corrosion Resistance of Nickel-Phosphorus Nano-ZnO Composite Multilayer Coating Electrodeposited on Carbon Steel in Acidic Chloride Environments  ** Even Aluminium nanocomposites!  At present, abundant CPs have been successfully manufactured, which indicates that the CPs formed by the combination of multiple ligands is more diversified and more powerful than that formed by single ligand [16u201319]. - [17]. C. Duan, Z. Su, Y. Cao, L. Hu, D. Fu, J. Ma, and Y. Zhang (2021). J. Clean. Prod. 283, 124635. ** Synthesis of core-shell u03b1-AlH3@Al(OH)3 nanocomposite with improved low-temperature dehydriding properties by mechanochemical mixing and ionic liquid treatment ** , 
  50 pregnant **rats** were used in this research were purchased from the Jinan University (Jinan, China). All the **rats** utilized in this study were placed at 12 h light or night and 20u201325 C standard environment. All the procedure in the present study was addmitted by the Jinan University Animal Ethics Committee (Jinan, China).  As we have concluded the inhibition of this compound on the levels of TNF-a and IL-1b in **mice** after distinct compound treatment. The authors should make up their minds whether they vivisected rats or mice. , 
 Tortured experimental section for X-ray crystallography. That sounds like a google translation (emphasis mine):  To collect the result of X-ray, the SuperNova diffractometer was utilized. Statistical analysis of **diverse intensity figures** was gathered through Crysalispro program and the data was recorded in **HKL pattern**. **The mode of SHELXS** using **direct means** was utilized to construct the **fundamental framework**, and the **mode of SHELXL-2014** using least square method was changed [25, 26]. Different **inhomogeneous parameters** are used to refine non hydrogen atoms. btw, SHELXL-2014 is considered as obsolete now. , 
  The cesarean section was conducted on the animals and the animal model of postpartum hemorrhage was constructed. After that, animal was injected with 1, 5, and 10 mg kg concentration of compound. Readers may wish to compare the present paper with [Yang, Li Zeng (2020)] and with [Wang et al (2020)] , which also claim to prevent postpartum hemorrhage using coordination polymers, involving the same absurd animal model. This allows me to recycle my comment from those threads: *After normal birth? Instead of? The defining feature of postpartum hemorrhage is placental non-separation. Do the authors and journal reviewers seriously believe that a surgical incision would be a valid model?* [Wu et al (2020)] are also of interest, for those authors again claimed to prevent postpartum hemorrhage (in mice) using CPs... though they forget to specify what strain of mice they used, or how many, or from where, or **what they did to induce bleeding**. ,