Long noncoding RNA SNHG14 promotes ovarian cancer cell proliferation and metastasis via sponging miR-219a-5p
Authors: R Zhang
S-J Li
L Li
Journal: European review for medical and pharmacological sciences (2019)
Discipline: PHARMACOLOGY & TOXICOLOGY
Keywords: ovarian cancer; long noncoding RNAs; lncRNA SNHG14; tumor progression; RT-qPCR
Affiliations: Department of Gynecology, Weifang People's Hospital, Weifang, China. .

Abstract:  Objective: The ovarian cancer is one of the most common fatal cancers. Recently, the role of long noncoding RNAs (lncRNAs) in tumor progression has attracted much attention in researchers. The aim of this study was to investigate the role of lncRNA SNHG14 in the progression of ovarian cancer and to explore the possible mechanism. Patients and methods: Real Time-quantitative Polymerase Chain Reaction (RT-qPCR) was utilized to detect SNHG14 expression in ovarian cancer tissues. To identify the function of SNHG14 in ovarian cancer, functional experiments were conducted in vitro and in vivo. In addition, the luciferase assays and RNA immunoprecipitation assay (RIP) were performed to investigate the underlying mechanism. Results: SNHG14 expression was remarkably higher in ovarian cancer tissues than that of corresponding normal tissues. SNHG14 expression was associated with patients' overall survival time as well. After SNHG14 was silenced in ovarian cancer cells, cell proliferation, migration, and invasion were remarkably inhibited. In addition, the expression of miR-219a-5p was significantly up-regulated after the silence of SNHG14. Further mechanism assays showed that miR-219a-5p was a direct target of SNHG14 in ovarian cancer. Conclusions: SNHG14 serves as a potential oncogene in ovarian cancer. In addition, it enhances ovarian cell metastasis and proliferation via sponging miR-219a-5p. 

Retracted: Yes

PubPeer comments:
 This paper is one of a set of 121 papers that all contain images from the same library of about 100 photos and plots. This is unexpected, because each paper has different authors and different affiliations, with little to no overlap, and describes different cancer types and molecules. It would be very hard to explain how authors from different labs would all obtain the same photo. Therefore, the papers might have all be derived from the same source, such as a paper mill that sells ready-to-be-published papers. This  Stock Photo paper set has been described in more detail on my blog post, https: scienceintegritydigest.com 2020 07 05 the-stock-photo-paper-mill and in a Wall Street Journal article by Eva Xiao (currently behind a paywall): https: www.wsj.com articles chinese-research-papers-raise-doubts-fueling-global-questions-about-scientific-integrity-11593939600 The vast majority (113 121) of the papers were published in the same journal, European Review for Medical and Pharmacological Sciences (ERMPS). A link to the full set of papers can be found here: https: docs.google.com spreadsheets d 172RWS18w1lTNJ9Nnj80fuXXTqTm4fGkoK0sdYyvKE3g edit?usp=sharing All papers have been reported to the journal editors on July 2, 2020. , 
 Retracted: https: www.europeanreview.org article 22175  Since this article has been suspected of research misconduct and the corresponding authors did not respond to our request to prove originality of data and figures, u201cLong noncoding RNA SNHG14 promotes ovarian cancer cell proliferation and metastasis via sponging miR-219a-5p, by L. Li, R. Zhang, S.-J. Li, published in Eur Rev Med Pharmacol Sci 2019; 23 (10): 4136-4142u2013DOI: 10.26355 eurrev_201905_17915u2013PMID: 31173283u201d has been withdrawn. The Publisher apologizes for any inconvenience this may cause. ,