Long non-coding RNA TTN-AS1 promotes tumorigenesis of ovarian cancer through modulating the miR-139-5p/ROCK2 axis
Authors: Xiaoxia Liu
Tingting Qi
Yiyang Li
Yanli Wang
Jihong Wen
Journal: Biomedicine & Pharmacotherapy (2020)
Discipline: PHARMACOLOGY & TOXICOLOGY
Keywords: Ovarian cancer; ROCK2; TTN-AS1; miR-139-5p.
Affiliations: Department of Gynecology, The First Hospital of Jilin University, 71#Xinmin Street, Chaoyang District, Changchun, 130021, China., Department of Gynecology, The First Hospital of Jilin University, 71#Xinmin Street, Chaoyang District, Changchun, 130021, China. Electronic address: .

Abstract:  This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief and the corresponding author. The panels from Figure 2C appear similar to panels from Figure 2C (after 180-deg flip) of the article previously published by Chunling Xu, Chunmei Hu, Yingxue Wang and Shu Liu in Biomedicine &amp; Pharmacotherapy 117 (2019) 109153 https://doi.org/10.1016/j.biopha.2019.109153 and Figure 8B of the article previously published by Dongmei Han, Jianfeng Wang and Guanghui Cheng in Oncotarget 9 (2018) 2395-2409 https://doi.org/10.18632/oncotarget.23416. The panels from figure 2G appear similar to panels from Figure 6D (after 180-deg flip) of the article previously published by Zhiguang Yang, Xingyu Lin, Peng Zhang, Yunpeng Liu, Zihao Liu, Benxin Qian, Xing Liu and Guoguang Shao in Biomedicine &amp; Pharmacotherapy 124 (2020) 109858 https://doi.org/10.1016/j.biopha.2020.109858 and Figure 5c of the article previously published by Zhen Liang, Xiao Wang, Xin Xu, Bo Xie, Alin Ji, Shuai Meng, Shiqi Li, Yi Zhu, Jian Wu, Zhenghui Hu, Yiwei Lin, Xiangyi Zheng, Liping Xie and Ben Liu in Molecular Cancer 16 (2017) 96 https://doi.org/10.1186/s12943-017-0664-1. 

Retracted: Yes

PubPeer comments:
 *[below]* Fig 2G.  Ki-67 expression was determined in xenograft tumors by IHC . *[above]* Fig 6D from [Yang et al (2020)] .  Immunohistochemistry examined the expression of Ki-67 in xenograft tissues from sh-LINC00525 and sh-NC groups . ![file] The panels appear to be the same, apart from a change in color balance and a 180-deg flip. How did this happen? , 
 Fig 2C.  Cell ... colony formation were determined in SKOV3 cells transduced with the lentivirus sh-TTN-AS1 and sh-NC . ![file] Fig 2C from [Xu et al (2019)] .  Cell colony formation was determined in SO-RB-50 and Y79 cells transfected with sh-NC or sh-SNHG6. With 180-deg flipped versions below, to facilitate comparisons. ![file] , 
 #2 Fig 2C again. ![] Now marked up for comparison with Figs 3C, 7D, 8B of [Han, Weng Cheng (2019)] . ![] , 
 #1 The panels of Fig 2G previously appeared as part of Figure 5c of  MicroRNA-608 inhibits proliferation of bladder cancer via AKT FOXO3a signaling pathway ([Liang et al, 2017] ) - Molecular Cancer, doi: 10.1186 s12943-017-0664-1. ![file] H t  [Actinopolyspora biskrensis]  . , 
 Retracted. No date or separate retraction notice yet. ---------------------------- This article has been retracted at the request of the Editor-in-Chief and the corresponding author. The panels from Figure 2C appear similar to panels from Figure 2C (after 180-deg flip) of the article previously published by Chunling Xu, Chunmei Hu, Yingxue Wang and Shu Liu in Biomedicine Pharmacotherapy 117 (2019) 109153 https: doi.org 10.1016 j.biopha.2019.109153 and Figure 8B of the article previously published by Dongmei Han, Jianfeng Wang and Guanghui Cheng in Oncotarget 9 (2018) 2395-2409 https: doi.org 10.18632 oncotarget.23416. The panels from figure 2G appear similar to panels from Figure 6D (after 180-deg flip) of the article previously published by Zhiguang Yang, Xingyu Lin, Peng Zhang, Yunpeng Liu, Zihao Liu, Benxin Qian, Xing Liu and Guoguang Shao in Biomedicine Pharmacotherapy 124 (2020) 109858 https: doi.org 10.1016 j.biopha.2020.109858 and Figure 5c of the article previously published by Zhen Liang, Xiao Wang, Xin Xu, Bo Xie, Alin Ji, Shuai Meng, Shiqi Li, Yi Zhu, Jian Wu, Zhenghui Hu, Yiwei Lin, Xiangyi Zheng, Liping Xie and Ben Liu in Molecular Cancer 16 (2017) 96 https: doi.org 10.1186 s12943-017-0664-1. ,