RETRACTED ARTICLE: LncRNA TUG1 protects against cardiomyocyte ischaemia reperfusion injury by inhibiting HMGB1
Authors: Hanyu Shi
Haiqing Gao
Zhenhua Dong
Journal: Artificial Cells Nanomedicine and Biotechnology (2019)
Discipline: BIOLOGY & BIOCHEMISTRY
Keywords: HMGB1; LncRNA TUG1; cardiomyocyte; ischaemia reperfusion injury.
Affiliations: Cadre Health Section, Qilu Hospital of Shandong University , Ji'nan , China., Department of Endocrinology, Jinan Central Hospital , Ji'nan , China.

Abstract:  The aim of this study was to investigate whether lncRNA TUG1 could mediate the progression of ischemia-reperfusion injury following acute myocardial infraction. Mouse cardiomyocytes HL-1 cells were subjected to oxygen glucose deprivation followed by reperfusion (OGD/R) to induce myocardial I/R injury. The expression of TUG1 was detected by real-time PCR. Overexpression or down expression of TUG1 was performed in mouse HL-1 cardiomyocytes. The myocardial cell viability and apoptosis were respectively detected. In addition, the expression levels of inflammatory factors, apoptosis-related proteins and HMGB1 proteins were detected. Besides, an inhibitor of HMGB1 was used to treat cells to verify the relationship between TUG1 and HMGB1 protein. The expression of TUG1 was significantly up-regulated in OGD/R-induced myocardial HL-1 cells. The overexpression of TUG1-induced inflammation and apoptosis in OGD-R-induced myocardial HL-1 cells. Knock down of TUG1 protected OGD/R-induced myocardial I/R injury by inhibiting HMGB1 expression. Suppression of lncRNA TUG1 may prevent myocardial I/R injury following acute myocardial infarction via inhibiting HMGB1 expression. 

Retracted: Yes

PubPeer comments:
 Retracted [11 January 2021] . ------------------------------- We, the Editors and Publisher of the journal Artificial Cells, Nanomedicine, and Biotechnology, have retracted the following article: Hanyu Shi, Zhenhua Dong Haiqing Gao (2019) LncRNA TUG1 protects against cardiomyocyte ischaemia reperfusion injury by inhibiting HMGB1. Artificial Cells, Nanomedicine, and Biotechnology, 47:1, 3511u20133516, DOI: 10.1080 21691401.2018.1556214 It has come to our attention that the full authorship list and affiliations for this manuscript were changed after the article was submitted. We have contacted the authors for an explanation, but we have not received a response within the requested timeframe. As determining authorship is core to the integrity of published work, we are therefore retracting the article. The authors listed in this publication have been sent notification. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as u2018Retractedu2019. , 
 Figs 3A and 4C in the paper do not bear close examination, with evidence of replication and manipulation. The journal should be aware of the possibility of peer-review shenanigans as well as authorship malarkey. ![file] The style of Western Blot composition shown here is unfamiliar to me, and worth looking out for, here and in other journals. ![file] ,