TWO Yb(III)-CONTAINING COORDINATION POLYMERS:STRUCTURAL INSIGHTS AND SYNERGY EFFECT WITH SEVENTY-FLAVOR PEARL PILLS ON CEREBRAL ISCHEMIA BY REGULATING MONOAMINE NEUROTRANSMITTERS
Authors: Ma, H.
Rong, H.
Zhang, J. -J.
Shi, J. -M.
Sun, Z. -Q.
Journal: Journal of Structural Chemistry (2020)
Discipline: CHEMISTRY
Keywords: Yb(III); coordination polymers; heterodonor organic ligands; solvothermal conditions; single crystal X-ray diffraction

Abstract: In this work, we report the synthesis of two new Yb(III)-based coordination polymers [Yb(Btca)(Idc)(H2O)]n (1, HBtca&nbsp;=&nbsp;1H-benzo[d][1,2,3]triazole-5-carboxylic acid and H3Idc&nbsp;=&nbsp;1H-imidazole-4,5-dicarboxylic acid) and [Yb2(Thz)3·8H2O)]·H2O (2, H2Thz&nbsp;=&nbsp;thiazolo[5,4-d]thiazole-2,5-dicarboxylic acid) prepared under the solvothermal conditions using two heterodonor organic ligands. The two complexes are fully determined via single crystal X-ray diffraction along with the elemental analysis. Furthermore, the synergy effect of compounds 1 and 2 with seventy-flavor pearl pills on the cerebral ischemic events is evaluated in vivo. Firstly, the enzyme-linked immunosorbent assay (ELISA) is performed to measure the content of dopamine and 5-serotonin in the brain after treatment with compounds 1 and 2. Then, the reactive oxygen species (ROS) detection is conducted to determine the inhibitory effect of the compounds on the inflammatory level in the brain.

Retracted: No

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 Fig 3: ![file] For comparison, Fig 3 of [Zheng Yang (2020)] : ![] , 
 The rationale for this paper is that the Yb(III) coordination polymers of the title apparently potentiate the effects of  Seventy-flavor pearl pills in reducing monoamine neurotransmitters (serotonin dopamine), thereby minimising the damage caused by cerebral ischemia in an animal model. Regrettably, the authors never describe the magic beans. We learn nothing about the constituents of the pearl pills, their supplier, the dosage. Without this information, the paper has no scientific value. How was it ever accepted for publication? Readers seeking more entertainment might enjoy  Two Yb(III) coordination polymers: treatment effect with seventy-flavor pearl pills on cerebral ischemia by reducing the content of monoamine neurotransmitters ([Zhao, Wang Sun 2020] ), which shares an author and appears to have come from the same production-line. -----------------------  Stroke is the third most deadly disease after heart disease and cancer. Annual health care costs in the United States are as high as $62 billion [1]. Currently, stroke treatments is imitated, and the only FDA-approved stroke treatment is the tissue plasminogen activator used to reopen blocked blood vessels [2]. - [2]. X. W. Ji, C. L. Wu, X. C. Wang, J. Liu, J. Z. Bi, and D. Y. Wang. Exp. Ther. Med., 2014, 8, 159. ** Monoamine neurotransmitters and fibroblast growth factor-2 in the brains of rats with post-stroke depression **  However, due to the narrow treatment window, this treatment is suitable only for a small number of patients. Therefore, it is imperative to find new therapies for clinic treatment [3]. - [3]. W. Chen, L. Chang, S. B. Ren, Z. C. He, G. B. Huang, and X. H. Liu. J. Hazard. Mater., 2020, 384, 121308. ** Direct Z-scheme 1D 2D WO 2.72 ZnIn 2 S 4 hybrid photocatalysts with highly-efficient visible-light-driven photodegradation towards tetracycline hydrochloride removal **  Both dopamine and 5-serotonin belong to monoamine neurotransmitters. Many studies have shown that the metabolism of extracellular monoamine neurotransmitters is disordered during cerebral ischemia, and the vital role of monoamine neurotransmitters in ischemic brain injury has received much attention of the researchers [4]. - [4]. J. Su, Z. Sheng, V. C. M. Leung, and Y. Chen. IEEE Wireless Commun., 2019, 26, 118. ** Energy Efficient Tag Identification Algorithms For RFID: Survey, Motivation And New Design **  Dopamine is mainly distributed in the nigra-striatum system in the brain. Previous studies have shown that the destruction of the substantia nigra causes dopamine depletion in the striatum, which protects striatal neurons from ischemic cell death [5]. - [5]. J. Zhao, M. Xin, J. Zhang, Y. Sun, S. Luo, H. Wang, Y. Wang, and X. Bi. Chemosphere, 2020, 243, 125380. ** Diclofenac inhibited the biological phosphorus removal: Performance and mechanism ** ,