miR-93-5p/IFNAR1 axis promotes gastric cancer metastasis through activating the STAT3 signaling pathway
Authors: Jing-Jing Liu
Shi-Ming Yang
Xin Yong
Hong-Bin Zhu
Yu-Feng Xiao
Dong-Hong Ma
Bo-Sheng Li
Dong-Xu Wang
Shu-Ming Wang
Yu-Yun Wu
Journal: Cancer Letters (2017)
Discipline: CLINICAL MEDICINE
Keywords: Gastric cancer; IFNAR1; Metastasis; STAT3; miR-93-5p.
Affiliations: Department of Gastroenterology, No. 254 Hospital of PLA, Tianjin, 300142, PR China., Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, PR China., Department of Gastroenterology, No. 254 Hospital of PLA, Tianjin, 300142, PR China. Electronic address: ., Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, PR China. Electronic address: .

Abstract:  Aberrant expression of microRNAs (miRNAs) plays an important role in gastric cancer (GC) development. miR-93-5p has shown opposing functions in different types of cancers, but the exact expression pattern and molecular mechanism of miR-93-5p in GC development remain to be elucidated. Here, we reported that miR-93-5p expression was increased in GC tissues compared with the adjacent normal tissues and that its overexpression was correlated with distant metastasis and poor survival in GC patients. miR-93-5p knockdown inhibited the migration, invasion and proliferation of GC cells in vitro and in vivo, while its overexpression displayed an opposite result. Using an mRNA microarray, we found that miR-93-5p significantly downregulated IFNAR1 expression in GC cells, which was further identified as a direct target of miR-93-5p. IFNAR1 knockdown promoted GC cell migration and invasion, but its restoration could rescue GC cell migration and invasion induced by miR-93-5p overexpression. Moreover, miR-93-5p-IFNAR1 axis increased MMP9 expression via STAT3 pathway in GC cells. Taken together, we reveal that miR-93-5p overexpression is associated with the poor survival of GC patients and miR-93-5p-IFNAR1 axis promotes GC metastasis through activation of STAT3 pathway. 

Retracted: No

PubPeer comments:
 Figure 2A shows an image duplication ![file] , 
 We thank the kind reader for indicating the mistake regarding to the representative picture of wound healing experiments in our paper. We did make a mistake of mixing up the picture reflecting wound healing of MKN28 with miR-93-5p mimics with that of MGC803 with anti-NC. Actually, the pictures of wound healing for 48 hours in MGC803 cells should be those of wound healing for 48 hours in MKN28 cells. We have corrected the wrong pictures and provided the corrected Figure 2, as shown as follow: ![file] We also applied to the editor of Cancer Letters to help us correct the misplaced pictures. The pictures of wound healing experiments for the repeat can be seen in online supplementary data Figure S3, and the website is: https: www.sciencedirect.com science article pii S0304383517305049 We apologize for the negligence in our work! We thank the reader again and thank the staff working for PuPeer very much! Best regards, Shiming Yang, Dong-Xu Wang, Dong-Hong Ma, Bo-Sheng Li, Jing-Jing Liu, Yu-Feng Xiao, Xin Yong, Shu-Ming Wang, Yu-Yun Wu, Hong-Bin Zhu , 
 February 1, 2021 The authors regret that an error occurred in Fig. 2, where, in Fig. 2A, two representative pictures of MGC803 cell wound healing for 48 hours had been provided wrongly. However, the error would not affect the general results of our paper at all. The authors carefully reviewed the paper again and made sure that no changes need to be made in other parts of the paper. The authors would like to apologize for any inconvenience caused. The correct Fig. 2 appears below. ![file] , 
 Thanks! We have asked the editor for help to make a Corrigendum to miR-93-5p IFNAR1 axis promotes gastric cancer metastasis through activating the STAT3 signaling pathway [Cancer Lett. 2017 Nov 1;408:23-32] in 2021 Feb 1, which can be observed in the website: https: pubmed.ncbi.nlm.nih.gov 32978018 . ![file] ![file] ,