Long non-coding RNA LINP1 induces tumorigenesis of Wilms' tumor by affecting Wnt/β-catenin signaling pathway
Authors: Q-F Sun
K-R Zhu
Y-Q Zhang
Journal: European review for medical and pharmacological sciences (2019)
Discipline: PHARMACOLOGY & TOXICOLOGY
Keywords: lncRNA; LINP1; Wilms' tumor; RT-qPCR; LUCAT1
Affiliations: Department of Pediatrics, Jining No. 1 People's Hospital, Jining, China. .

Abstract:  Objective: Recent studies have discovered that long non-coding RNAs (lncRNAs) play an important role in the development of malignant tumors. The aim of this work was to investigate the exact role of lncRNA LINP1 in the development of Wilms' tumor and to explore the possible underlying mechanism. Patients and methods: The expression of lncRNA in non-homologous end joining pathway 1 (LINP1) in tissue samples of Wilms' tumor was detected by Real Time-quantitative Polymerase Chain Reaction (RT-qPCR). The relationship between the expression of lung cancer associated transcript 1 (LUCAT1) and patients' overall survival time was analyzed. Subsequent functional experiments were conducted to identify the changes in biological behaviors of Wilms' tumor cells after the gain or loss of LINP1. Moreover, the underlying mechanism of LINP1 function was explored. Results: QRT-PCR results showed that LINP1 expression level in Wilms' tumor tissues was significantly higher than that of adjacent tissues. LINP1 expression was negatively associated with the overall survival time of patients with Wilms' tumor. Cell growth ability was markedly inhibited and promoted after down-regulation and overexpression of LINP1 in vitro, respectively. Moreover, after the loss and gain of LINP1 in vitro, cell migration and invasion abilities were remarkably repressed and promoted, respectively. Furthermore, the loss of LINP1 in vitro could significantly decrease the expressions of targeted proteins in the Wnt/β-catenin signaling pathway. However, the expressions of targeted proteins in the Wnt/β-catenin signaling pathway were remarkably up-regulated after over-expression of LINP1. Conclusions: LINP1 could enhance cell metastasis and proliferation via inducing the Wnt/β-catenin signaling pathway. Our findings might provide a new prospect for the diagnosis and therapy of Wilms' tumor. 

Retracted: Yes

PubPeer comments:
 This paper is one of a set of 121 papers that all contain images from the same library of about 100 photos and plots. This is unexpected, because each paper has different authors and different affiliations, with little to no overlap, and describes different cancer types and molecules. It would be very hard to explain how authors from different labs would all obtain the same photo. Therefore, the papers might have all be derived from the same source, such as a paper mill that sells ready-to-be-published papers. This  Stock Photo paper set has been described in more detail on my blog post, https: scienceintegritydigest.com 2020 07 05 the-stock-photo-paper-mill and in a Wall Street Journal article by Eva Xiao (currently behind a paywall): https: www.wsj.com articles chinese-research-papers-raise-doubts-fueling-global-questions-about-scientific-integrity-11593939600 The vast majority (113 121) of the papers were published in the same journal, European Review for Medical and Pharmacological Sciences (ERMPS). A link to the full set of papers can be found here: https: docs.google.com spreadsheets d 172RWS18w1lTNJ9Nnj80fuXXTqTm4fGkoK0sdYyvKE3g edit?usp=sharing All papers have been reported to the journal editors on July 2, 2020. , 
 Withdrawn [February 2021] .  Since this article has been suspected of research misconduct and the corresponding authors did not respond to our request to prove originality of data and figures, u201cLong non-coding RNA LINP1 induces tumorigenesis of Wilmsu2019 tumor by affecting Wnt u03b2-catenin signaling pathway, by K.-R. Zhu, Q.-F. Sun, Y.-Q. Zhang, published in Eur Rev Med Pharmacol Sci 2019; 23 (13): 5691-5698u2013DOI: 10.26355 eurrev_201907_18306u2013PMID: 31298321u201d has been withdrawn. The Publisher apologizes for any inconvenience this may cause. , 
 [Source: Jining First People s Hospital Release time: 2021-12-17] : In order to strengthen the construction of scientific research integrity, severely punish violations, and create a good environment for scientific and technological innovation, the relevant paper issues recently investigated and dealt with by this unit are hereby notified as follows. 18. The paper  Long non-coding RNA LINP1 induces tumorigenesis of Wilms tumor by affecting Wnt u03b2-catenin signaling pathway , published by Zhang Yanqin as the corresponding author, Zhu Kangru as the first author, and Sun Qiufen as the co-first author, was investigated. , there is academic misconduct by fabricating the research process. The relevant responsible persons are dealt with as follows: Zhang Yanqin (corresponding author): Cancellation of the application qualifications for scientific research projects, scientific research awards, scientific and technological achievements, scientific and technological talent plans within 5 years; and other qualifications; cancel the membership or membership of academic institutions such as societies, associations, etc.; recover the author s personal research awards and honorary titles; postpone promotion to a higher-level professional and technical position for 1 year; instruct the magazine to contact the magazine as soon as possible Withdrawal; Administrative Warning. Zhu Kangru (first author): Cancellation of application qualifications for scientific research projects, scientific research awards, scientific and technological achievements, scientific and technological talent plans, etc. within 5 years; cancellation of 5-year qualifications as nominees or recommenders, nominees or recommenders, review experts, etc.; Membership or membership of academic institutions such as societies, associations, etc.; recovering the author s personal research awards and honorary titles; deferring promotion to a higher-level professional and technical position for 1 year; administrative warning. Sun Qiufen (tied for the first author): The scientific research integrity admonition talk; the hospital circulates the criticism. ,