Two Mixed-Ligand Co(II)-Based Coordination Polymers: Application Value in the Later Rehabilitation of Fracture Patients by Activating WNT Signaling Pathway
Authors: Shen, Juan
Qi, Yu-Jun
Kan, Zheng-Hua
Bi, Chuan-Hao
Journal: Journal of Cluster Science (2020)
Discipline: CHEMISTRY
Keywords: Coordination polymers; Co(II) ions; hydrothermal reaction; chemical formulae; rehabilitation

Abstract: Two coordination polymers containing Co(II) ions as the metal source have been prepared by the hydrothermal reaction, and their chemical formulae are {[Co(Hnbta)(bimm)](3H2O)}n (1) and {[Co1.5(nbta)(pyim)(H2O)](2H2O)}n (2) (pyim\u2009=\u2009N-(4-pyridylmethyl)imidazole, bimm\u2009=\u2009bis(imidazol-1-yl)methane and H3nbta\u2009=\u20095-nitro-1,2,3-benzenetricarboxylic acid) and. The application values of the new compound in the later rehabilitation of fracture patients were assessed and the detailed mechanism was investigated as well. First of all, the Vascular endothelial growth factor (VEGF) content and Fibroblast growth factor (FGF) content was evaluated with enzyme linked immunosorbent assay (ELISA) detection kit, and the results indicated compound 1 was much stronger than compound 2 on increasing the VEGF and FGF content. In addition to this, the activation levels of the Wingless-type (Wnt) signaling pathway in mesenchymal stem cells was followed by western blotting assay, the data suggested that compound 1 could up-regulated the activation levels of the Wnt signaling pathway.

Retracted: No

PubPeer comments:
 The authors to have acquired mesenchymal stem cells from an unspecified source (animal? human? their own?) and cultivated them in an unspecified culture medium, before exposing them in an unspecified way to insoluble crystals.  In short, the mesenchymal stem cells in the **phage of logical growth** were harvested and inoculated into plates of 6 well at 10^6 cells each well ultimate destiny. Then, the cells were treated through the compound 1 or the compound 2 at 5 mg mL concentration, using the Insulin-like growth factor (IGF) was the positive control. After that, the cell supernatant was harvested and the VEGF and FGF content was detected through the indicated ELISA kit. That exposure supposedly changed the MSCs protein expression, therefore the crystals will be useful  in the later rehabilitation of fracture patients . The curious term  phage of logical growth is often found in [the products of a prolific papermill] (along with  ultimate destiny ,  preformation and  logical growth phage ). ![] , 
 In another indication of a production-line provenance, the examples in the References of coordination polymer include random papers (part of a recycled list) that are not about coordination polymers.  In the past several years, the design as well as development for the coordination polymers (CPs) have received great attention in many scientific fields, not only due to their topological structure and molecular connectivity, but also owing to their extensive range of potential industrial and social applications, for instance, molecular recognition, drug delivery, heterogeneous catalysis, luminescence, optics, and sensing, ion electron conductivity, and ion exchange, gas adsorption as well as biomedicine [5u201310]. - [9]. J. Zhao, J. Zhang, D. Zhang, Z. Hu, and Y. Sun (2021). Sci. Total Environ. 752, 141932. ** Effect of emerging pollutant fluoxetine on the excess sludge anaerobic digestion ** - [10]. F. K. Yu, Y. Wang, H. R. Ma, and M. H. Zhou (2020). Sep. Purif. Technol. 248, 117022. ** Hydrothermal synthesis of FeS2 as a highly efficient heterogeneous electro-Fenton catalyst to degrade diclofenac via molecular oxygen effects for Fe(II) Fe(III) cycle **  Furthermore, similar to the natural zeolites, the CPs also possesses large holes in the structures; nevertheless, the adaptability and versatility of the connector in the coordination pattern, as well as the metal ions geometric preference, are conducive to adjusting the topological structure and porosity of the synthesized structure, which is superior to mesoporous silica and zeolites [5, 11u201313] - [12]. F. K. Yu, Y. Chen, Y. W. Pan, Y. Yang, and H. R. Ma (2020). Sep. Purif. Technol. 241, 116695. ** A cost-effective production of hydrogen peroxide via improved mass transfer of oxygen for electro-Fenton process using the vertical flow reactor ** --------------------------------- The CCDC database informs me that the crystal-structure determination data and parameters for the present compounds were both deposited there as data sets [2015742] and [2015743] , with Haitao Yuan of Bohai University as the crystallographer. No-one of that name is credited in the paper. By my count, Haitao Yuan provided the CCDC database [with 134 data sets] , many of them used in problematic papers. ,