Higher dietary lycopene intake is associated with longer cardiac event-free survival in patients with heart failure
Authors: Debra Moser
Terry Lennie
Martha Biddle
Seongkum Heo
Susan Pressler
Eun Kyeung Song
Sandra B Dunbar
Heather Payne-Emerson
Journal: European Journal of Cardiovascular Nursing (2013)
Discipline: CLINICAL MEDICINE
Keywords: Lycopene; antioxidants; heart failure; sodium.
Affiliations: College of Nursing, University of Kentucky, USA, Department of Nursing, College of Medicine, University of Ulsan, South Korea, College of Nursing, University of Arkansas for Medical Sciences, USA, Department of Wellness and Therapeutic Sciences, Murray State University, USA, Nell Hodgson Woodruff School of Nursing, Emory University, USA, College of Nursing, University of Michigan, USA

Abstract:  Background: The antioxidant lycopene may be beneficial for patients with heart failure (HF). Processed tomato products are a major source of lycopene, although they are also high in sodium. Increased sodium intake may counter the positive antioxidant effect of lycopene. Methods: This was a prospective study of 212 patients with HF. Dietary intake of lycopene and sodium was obtained from weighted 4-day food diaries. Patients were grouped by the median split of lycopene of 2471 µg/day and stratified by daily sodium levels above and below 3 g/day. Patients were followed for 1 year to collect survival and hospitalization data. Cox proportional hazards modeling was used to compare cardiac event-free survival between lycopene groups within each stratum of sodium intake. Results: Higher lycopene intake was associated with longer cardiac event-free survival compared with lower lycopene intake (p = 0.003). The worst cardiac event-free survival was observed in the low lycopene intake group regardless of sodium intake (&gt; 3 g/day HR = 3.01; p = 0.027 and ≤ 3 g/day HR= 3.34; p = 0.023). Conclusion: These findings suggest that increased lycopene intake has the potential to improve cardiac event-free survival in patients with HF independent of sodium intake. 

Retracted: No

PubPeer comments:
 Plagiarising a comment by Elisabeth Bik: ----------------------------------------- This paper belongs to a set of over 600 papers (as per May 2021) that share very similar Western blots with tadpole-like shaped bands, the same background pattern, and striking similarities in title structures, paper layout, bar graph design, and - in a subset - flow cytometry panels. Despite these similarities, these papers are authored by researchers from different departments and institutes, with almost no overlap in authors. The list of these papers is available here: https: docs.google.com spreadsheets d 1KXqTAyl4j-jVorFPMD2XRpr76LcIKJ0CVyIvRj0exYQ edit?usp=sharing A more detailed description of this set of papers, suspected to all be generated by a common source, a paper mill , can be found here: - https: forbetterscience.com 2020 01 24 the-full-service-paper-mill-and-its-chinese-customers (January 2020) - https: scienceintegritydigest.com 2020 02 21 the-tadpole-paper-mill (February 2020) The same paper mill has been described in these papers: - Jana Christopher - Systematic fabrication of scientific images revealed - FEBS Letters (2018) - https: febs.onlinelibrary.wiley.com doi full 10.1002 1873-3468.13201 - Jennifer A Byrne and Jana Christopher - Digital magic, or the dark arts of the 21st centuryu2014how can journals and peer reviewers detect manuscripts and publications from paper mills? - FEBS Letters (2020) - https: febs.onlinelibrary.wiley.com doi full 10.1002 1873-3468.13747 ------------------------------------------------ E.g. Fig 10. ![file] ,