Castleman&rsquo;s disease in the HIV-endemic setting
Authors: Emmanuel-Akinola Abayomi
Minodora-Silvia Desmirean
Esam-Rajab Mahroug
Candice Sher-Locketz
Ciprian Tomuleasa
Ravnit Grewal
Journal: Cancer Management and Research (2018)
Discipline: CLINICAL MEDICINE
Keywords: CD4 count; Castleman’s disease; HHV-8 status; HIV-endemic setting; clinico-pathological correlation.
Affiliations: Division of Haematology, Department of Pathology, University of Stellenbosch, Tygerberg Academic Hospital, Cape Town, South Africa., Department of Pathology, Military Hospital of Cluj Napoca, Cluj Napoca, Romania., Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania, ., Department of Hematology, Nigeria Institute for Medical Research, Lagos, Nigeria., Research Center for Functional Genomics and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania, ., Department of Hematology, Ion Chiricuta Clinical Research Center, Cluj Napoca, Romania, ., Department of Pathology, South African Bioinformatics Institute, University of The Western Cape, Bellville, South Africa.

Abstract:  Introduction: Castleman's disease (CD), first described by Benjamin Castleman in 1954, is a giant or angiofollicular lymph node hyperplasia, described as a rare monotypic polyclonal B-cell lymphoproliferative disorder with an incompletely understood pathogenesis and variable clinical behavior. This study aimed to determine the incidence of CD diagnosis over an 11-year period. Additionally, the study aimed to describe the demographic, laboratory, and pathological features of CD. Methods: This is a retrospective study where the demographic and laboratory data were retrieved from the Tygerberg Academic Hospital (TAH) patient electronic records and Tygerberg Lymphoma Study Group (TLSG) and statistical analysis performed on the patients diagnosed with CD. Results: Fifty-four patients were diagnosed with CD during this period. The median age at presentation was 39 years (range: 9-58). HIV serology was available in 53 patients, of which 51 were HIV-positive and two were HIV-negative. The history of initiation of antiretroviral therapy at diagnosis was available in 43 patients (38 on treatment, four were not on treatment, and one defaulted treatment). The median CD4 count was 232.50 cells/μL (range: 2-883). The HIV viral load was performed in 43 patients at diagnosis, which was &lt;49 HIV-1 RNA copies/μL in more than half of the patients (58%). Diagnosis was made on lymph node biopsies in 53 patients, with one case diagnosed on a spleen biopsy. Kaposi sarcoma was found on the same tissue biopsy in 13 cases. A bone marrow biopsy was performed in 31 patients. The predominant features noted were a disorganized hypercellular marrow with plasmocytosis. Conclusion: CD is a rare polyclonal B-cell lymphoproliferative disorder. However, we demonstrated a significant increase in the incidence of HIV-associated multicentric CD over the last decade in our area in South Africa. 

Retracted: Yes

PubPeer comments:
 One of the bands in Figure 5C contains some unusually sharp areas of transition, that could suggest a copy and paste was performed. Could the authors share an image of the uncropped original scans? *** Closeup ![file] *** ![file] ,