Tumor-targeting peptides from combinatorial libraries
Authors: Wenwu Xiao
Ruiwu Liu
Xiaocen Li
Kit S Lam
Journal: Advanced Drug Delivery Reviews (2017)
Discipline: PHARMACOLOGY & TOXICOLOGY
Keywords: Biological library; Cell surface receptor; High throughput screening; One-bead one-compound peptide library; Phage-display peptide library
Affiliations: Department of Biochemistry and Molecular Medicine, University of California Davis, Sacramento, CA 95817, USA; University of California Davis Comprehensive Cancer Center, Sacramento, CA 95817, USA., Department of Biochemistry and Molecular Medicine, University of California Davis, Sacramento, CA 95817, USA; University of California Davis Comprehensive Cancer Center, Sacramento, CA 95817, USA; Division of Hematology & Oncology, Department of Internal Medicine, University of California Davis, Sacramento, CA 95817, USA.

Abstract:  Cancer is one of the major and leading causes of death worldwide. Two of the greatest challenges in fighting cancer are early detection and effective treatments with no or minimum side effects. Widespread use of targeted therapies and molecular imaging in clinics requires high affinity, tumor-specific agents as effective targeting vehicles to deliver therapeutics and imaging probes to the primary or metastatic tumor sites. Combinatorial libraries such as phage-display and one-bead one-compound (OBOC) peptide libraries are powerful approaches in discovering tumor-targeting peptides. This review gives an overview of different combinatorial library technologies that have been used for the discovery of tumor-targeting peptides. Examples of tumor-targeting peptides identified from each combinatorial library method will be discussed. Published tumor-targeting peptide ligands and their applications will also be summarized by the combinatorial library methods and their corresponding binding receptors. 

Retracted: No

PubPeer comments:
 The text below and Reference 20 is copied from the commented article and can be interpreted as stating that the synthesis of OBOC libraries is first described the article cited in the list of references. *OBOC combinatorial libraries can be created using synthetic chemistry to link various building blocks to form a large number of compounds, ranging from peptides to synthetic small molecules on beads, such that each bead displays an unique chemical entity [20]. 20. Lam KS, Salmon SE, Hersh EM, Hruby VJ, Kazmierski WM, Knapp RJ. A new type of synthetic peptide library for identifying ligand-binding activity. Nature. 1991; 354:82u2013 84. * There is however another statement written by one of the authors of the commented article (KSL) that can be found in the Ruiwu Liu, Xiaocen Li,Wenwu Xiao, Kit S. Lam Corrigendum to u2018Tumor-targeting peptides from combinatorial librariesu2019 [Adv Drug Deliv Rev.110u2013111 (2017) 13u201337]. *Standard solid phase peptide synthesis employing Fmocchemistry and split-mix strategy [Furka et al.] are commonly used for the synthesis of OBOC peptide libraries (Fig. 8) [11,94]. u00c1. Furka, F. Sebestyu00e9n, M. Asgedom, G. Dibu00f3, General method for rapid synthesis of multicomponent peptide mixtures, Int. J. Pept. Protein Res. 37 (1991) 487u2013493.* Only one of the two statements can be true. Can the co-author of both articles (Kit S. Lam) explain the discrepancy? ,