Protective effect of co-administration of curcumin and sildenafil in alcohol induced neuropathy in rats
Authors: Amarjeet Singh
T Prakash
Maninder Kaur
Amit Bhatia
Monica Gulati
Adil Hussain Malik
Sachin Kumar Singh
Palak Bawa
Bimlesh Kumar
Journal: European Journal of Pharmacology (2017)
Discipline: PHARMACOLOGY & TOXICOLOGY
Keywords: Alcohol neuropathy; Curcumin; Oxidative stress; Sildenafil.
Affiliations: School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India., School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India. Electronic address: ., Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India., Department of Physiology and Pharmacology, Acharya and B.M. Reddy College of Pharmacy, Bangalore, Karnataka, India.

Abstract:  Neuropathic pain associated with chronic alcohol consumption is a medico-socioeconomical problem that affects both central and peripheral nervous system and has no satisfactory treatment till date. The present study was designed to investigate the protective effect of co-administration of curcumin and sildenafil on alcohol induced neuropathic pain in rats. In order to carry out this, ethanol (35% v/v, 10g/kg, p.o.) was administered for 10 weeks to induce neuropathic pain. Curcumin (30 and 60mg/kg, i.p.) and sildenafil (5 and 10mg/kg, i.p.) were given alone and in combination at their lower doses (30mg/kg curcumin and 5mg/kg, sildenafil, i.p.) to investigate the changes in thermal and mechanical hyperalgesia, allodynia and histopathological parameters. Biochemical estimations of thiobarbituric acid reactive species, glutathione and protein was also carried out to evaluate oxidative stress. The results revealed that chronic alcohol consumption for 10 weeks caused significant thermal and mechanical hyperalgesia, allodynia and increased oxidative stress. Individual administration of both the drugs at their low as well as high doses were able to improve the symptoms of alcohol induced neuropathic pain. Whereas co-administration of curcumin and sildenafil at their lower doses itself were found to significantly improve nerve functions, biochemical and histopathological parameters as compared to their individual administration. It is therefore proposed that co-administration of curcumin and sildenafil may bring new dimension towards attenuation of alcohol induced neuropathic pain affecting central as well as peripheral nervous system. 

Retracted: No

PubPeer comments:
 Figure 3. * Red boxes: The two Day 14 panels, representing two different animal groups, appear to be showing an overlap. ![file] , 
 **Figure Overlap** **Before corrigendum** Fig.4A upper left, Fig.3A upper right, and Fig.3A lower right, representing two different animal groups (PRP Control) and staining groups (Ki67 a-SMA), came from one figure (overlap). ![file] **After corrigendum** Fig.4A upper left, and Fig.3A upper left, representing two different staining groups (Ki67 a-SMA), came from one figure (overlap). ![file] , 
 The authors provided the correspondence as below ** Corresponding Author: Yibing Wang, Department of plastic surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, 16766# Jing 10 Road, Jinan 250014, Shandong Province, PR China. E-mail address: wybslyy@163.com. Telephone number: +8618678185793. Fax number: +8605332360221. ** My wife (Chinese) told me that in China, legal cell-phone number was real-name registered, and every city got a unique area code for the call to a landline phone or fax. I searched the Fax number of the corresponding author,  **8605332360221** , on Google:  86 means China,  0533 means Zibo City, not Jinan. Then the phone number,  **8618678185793** , also belongs to someone in Zibo,  Zibo, China Unicom , not Jinan. It appears that the contact information of the corresponding author didn t belong to the claimed corresponding author, Yibing Wang, but someone in Zibo city. It s easy for the organization (their hospitals) and journal office (J Burn Care Res) to find out the truth, since the phone  **8618678185793** should be real-name registered. ,