Beneficial effects of sulfonamide‑based gallates on osteoblasts in vitro
Authors: Pan Jin
Li Huang
Li Zheng
Cuiwu Lin
Jinmin Zhao
Xiao Lin
Journal: Molecular Medicine Reports (2017)
Discipline: CLINICAL MEDICINE
Keywords: Osteoporosis; Antioxidants; Gallic acid; Sulfonamide; JEZ-C
Affiliations: Guangxi Engineering Center for Biomaterials for Tissue and Organ Regeneration, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China., School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi 530004, P.R. China.

Abstract:  Effective treatments for osteoporosis remain fairly elusive; however, studies have reported that antioxidants may aid in the maintenance of reactive oxygen species at a favorable level, in order to prevent osteoporosis. Gallic acid (GA) and its derivatives are potent antioxidative and anti‑inflammatory agents that affect several biochemical and pharmacological pathways; however, GA is slightly cytotoxic and suppresses cell proliferation. The present study modified GA by the introduction of sulfonamide, in order to obtain a novel compound known as JEZ‑C, and investigated its effects on osteoblasts by measuring cell proliferation, viability, morphology, alkaline phosphatase (ALP) activity, and the expression of relevant osteoblast markers. Results indicated that JEZ‑C may effectively promote osteoblast growth. JEZ‑C increased ALP activity, upregulated the expression of osteogenic‑related genes, including runt‑related transcription factor 2, bone sialoprotein, osteocalcin and alpha‑1 type I collagen, thus indicating that JEZ‑C enhances bone matrix production and mineralization. The recommended range of JEZ‑C concentration is between 6.25x10‑3 and 6.25x10‑1 µg/ml, within which cell growth was promoted compared with the control. Specifically, treatment with 6.25x10‑2 µg/ml JEZ‑C is ideal. These findings may represent a novel approach to cell‑based therapy for the treatment of osteoporosis. 

Retracted: No

PubPeer comments:
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 Corridendum [13 May 2021] . -------------------------  Following the publication of the above article, an interested reader drew to the authors attention that three figures in their paper (namely Figs. 2, 4 and 5) appeared to feature panels containing overlapping data. The authors reu2011examined their original data, and realized that they had made inadvertent errors in the compilation of the data in these figures; specifically, the data shown in the panels for Fig. 2G, Fig. 4C, D and I, and Fig. 5E and I had been selected incorrectly. The corrected versions of Figs. 2, 4 and 5 are shown below and on the next page. All the authors approve of this corrigendum, and are grateful of the Editor of *Molecular Medicine Reports* for granting them the opportunity to publish this corrigendum. Furthermore, they regret that these errors were introduced into the paper, even though they did not substantially alter any of the major conclusions reported in the paper, and apologize to the readership for any inconvenience caused. No figures are appended in the original. ,