KLF5 promotes cervical cancer proliferation, migration and invasion in a manner partly dependent on TNFRSF11a expression
Authors: Dong Ma
Shan Zhao
Qi Zhang
Ou Li
Ling-Ya Chang
Xin-Yue Wang
Fu-Yuan Cao
Jun-Jian Zhao
Mei-Li Geng
Huan-Yu Zheng
Lu Yuan
Yan-Jie Xiong
Journal: Scientific Reports (2017)
Discipline: Multidisciplinary
Keywords: KLF5; TNFRSF11a; cervical carcinogenesis; tumour cell proliferation; invasiveness
Affiliations: School of Public Health, North China University of science and technology, Jianshe Road 57, Tangshan, 063000, Hebei, China., Department of Cancer Second Division, The Second Hospital of Hebei Medical University, 215 Heping West Road, Shijiazhuang, 050000, Hebei, China., North China University of Science and Technology Affiliated Hospital, Jianshe Road 57, Tangshan, 063000, Hebei, China., Department of Obstetrics and Gynecology, Workers' Hospital of Tangshan, Wenhua road 27, Tangshan, 063000, Hebei, China., Department of Obstetrics and Gynecology, Workers' Hospital of Tangshan, Wenhua road 27, Tangshan, 063000, Hebei, China. .

Abstract:  Although the transcription factor Krüppel-like factor 5 (KLF5) plays important roles in both inflammation and cancer, the mechanism by which this factor promotes cervical carcinogenesis remains unclear. In this study, we demonstrated a potential role for tumour necrosis factor receptor superfamily member 11a (TNFRSF11a), the corresponding gene of which is a direct binding target of KLF5, in tumour cell proliferation and invasiveness. Coexpression of KLF5 and TNFRSF11a correlated significantly with tumorigenesis in cervical tissues (P &lt; 0.05) and manipulation of KLF5 expression positively affected TNFRSF11a mRNA and protein expression. Functionally, KLF5 promoted cancer cell proliferation, migration and invasiveness in a manner dependent partly on TNFRSF11a expression. Moreover, in vivo functional TNFRSF11a-knockdown mouse studies revealed suppression of tumorigenicity and liver metastatic potential. Notably, tumour necrosis factor (TNF)-α induced KLF5 expression by activating the p38 signalling pathway and high KLF5 and TNFRSF11a expression increased the risk of death in patients with cervical squamous cell carcinoma. Our results demonstrate that KLF5 and TNFRSF11a promote cervical cancer cell proliferation, migration and invasiveness. 

Retracted: No

PubPeer comments:
 Figures 2e and 3f appear to include an overlapping image for two conditions. *** ![file] , 
 There are many more. Journal notified. *** 5c and 5d ![file] *** 2d ![file] 2j ![file] , 
 Here s a consolidated view. *** From Figure 2 ![file] *** From Figure 3 ![file] *** From Figure 5 ![file] , 
 Dear Actinopolyspora Biskrensis, Thanks for your comments. We checked our original data. We thank you very much for pointing this out, as we hadnu2019t noticed this error till you mentioned it. We are really sorry about this and have corrected them. The corrigendum is available online.![file] ![file] ![file] , 
 #4 Thank you for responding. Are you saying the correction has already been published? I wasn t able to find it myself - perhaps you can share the link. TAM , 
 #5 We are communicating with the scientific reports journal to make corrections. Once the modification is completed, the link will be generated and we will send it to you as soon as possible. Ou Li , 
 #6 Is there an update on this correction? ,