Quercetin ameliorates lipopolysaccharide-caused inflammatory damage via down-regulation of miR-221 in WI-38 cells
Authors: Jianke Liu
Chong Wang
Mengxue Zhang
Zhenghai Qu
Lei Xu
Zhaochuan Yang
Lingpeng Kong
Journal: Experimental and Molecular Pathology (2019)
Discipline: CLINICAL MEDICINE
Keywords: Inflammatory response; JNK pathway; MicroRNA-221; NF-κB pathway; Pneumonia
Affiliations: Children's Medical Center, The Affiliated Hospital of Qingdao University, Qingdao 266000, China., Children's Medical Center, The Affiliated Hospital of Qingdao University, Qingdao 266000, China. Electronic address: .

Abstract:  This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. Given the comments of Dr Elisabeth Bik regarding this article “… the Western blot bands in all 400+ papers are all very regularly spaced and have a smooth appearance in the shape of a dumbbell or tadpole, without any of the usual smudges or stains. All bands are placed on similar looking backgrounds, suggesting they were copy/pasted from other sources, or computer generated”, the journal requested the authors to provide the raw data. However, the authors were not able to fulfil this request and therefore the Editor-in-Chief decided to retract the article. 

Retracted: No

PubPeer comments:
 Is this a joke? Or the result of preparing the References separately from the main text, following a different template?  Most patients may have normal liver function or only mild inflammation and necrosis of liver tissue, while the others may develop liver cirrhosis and liver cancer [2, 3]. - [3]. L. Kang, L. Zhao, S. Yao, and C. Duan (2019). Ceram. Int.45, 16717. ** A new architecture of super-hydrophilic u03b2-SiAlON graphene oxide ceramic membrane for enhanced anti-fouling and separation of water oil emulsion **  More and more research reports have shown that liver cirrhosis can be caused by HBV infection, which in turn causes cancer of liver cells [4]. - [4]. Y. Y. Yang, L. Kang, and H. Li (2019). Ceram. Int.45, 8017. ** Enhancement of photocatalytic hydrogen production of BiFeO3 by Gd3+ doping **  Thus, elucidating the characteristics of important pathogenic factors in the pathogenesis of hepatitis B in cirrhosis, and preventing cirrhosis of decompensated liver cirrhosis has great significance for the development of liver cancer treatment [5]. - [5]. D. Zhang, H. Q. Zhang, S. Zhao, Z. G. Li, and S. X. Hou (2019). Int. J. Electrochem. Sci.14, 4659. ** Electrochemical Impedance Spectroscopy Evaluation of Corrosion Protection of X65 Carbon Steel by Halloysite Nanotube-Filled Epoxy Composite Coatings in 3.5% NaCl Solution ** , 
 This is one of a large number of coordination-chemistry papers that appear to have all been written according to a template. - All draw on the same small pool of papers to illustrate the broad range of applications and properties of MOFs. Even when the in-text citations match the references, one might expect independent authors to think of different examples. - Many cite Zhao, Kang and Yao (2019) -- **Research and Application of Acoustic Emission Signal Processing Technology** -- which is completely irrelevant to the topic, but became part of the template anyway. - The vast majority of email identities for corresponding authors were formed by taking an underscore-separated name and appending 666 or 66 . I am advised that these are auspicious numbers with positive associations. So one possibility is that the authors all decided independently to generate email accounts with this format. The alternative is that *some outside contractor* handled the task of negotiating with journals (generating these disposable accounts in the process) - perhaps also the task of writing the manuscripts, using a single Bibliography file to save time. In the following, (some of) the recurring References are labelled 1 to 14 . Searching for other papers that cite them might be informative. ----------------------------- -  [A New Cu(II)-Based Metalu2013Organic Framework for Highly Selective C2H2 C2H4 Separation and Prevention Against Carcinogenesis of Cirrhosis via Down-Regulating the CXCR3 Mediated Inflammatory Pathway]  (Chen et al 2020; zhigang_chen**666**@sina.com). 8, 10 -  [Synthesis, Structure and In Vitro Anti-gastric Cancer Activity of Two New Mixed-Ligand Cu(II) and Cd(II)-Coordination Polymers]  (Wan et al 2019; xiaolong_wan**666**@126.com). 6 -  [A New Cu(I)-Based Coordination Polymer: Crystal Structure, Molecular Docking and Protective Effect in Streptococcuspneumoniae-Infected Mice by Promoting Immune Cell Response]  (Zhang et al 2019; yongji_wang**66**@126.com). 3, 4, 7, 8, 10, 12, 13 -  [A InIII-MOF with Imidazole Decorated Pores as 5-Fu Delivery System to Inhibit Colon Cancer Cells Proliferation and Induce Cell Apoptosis in vitro and in vivo]  (Li et al 2019; debao_lu**666**@126.com). 4, 5, 6, 7, 9, 10, 11, 14 -  [Three-Dimensional Ni(II)-MOF Containing an Asymmetric Pyridyl-Carboxylate Ligand: Catalytic Cyanosilylation of Aldehydes and Inhibits Human Promyelocytic Leukemia Cancer Cells]  (Xi et al 2019; zijian_li**666**@126.com) 4, 5, 6, 7, 10, 11, 14 -  [A New Zn(II)-Diisophthalate MOF for Solvent-Free Cyanosilylation of Aldehydes and Anti-colon Cancer Activity Study]  (Lu et al 2019; li_liao**666**@126.com). 4, 5, 6, 10, 11, 14 -  [Solvent-Free Cyanosilylation of Aldehydes and Anti-cervical Cancer Activity of a Highly Porous Zinc-MOF]  (Li et al 2019; liping_zhang**666**@163.com) 4, 5, 6, 7, 9, 10, 11, 13, 14 -  [A New Porous Metalu2013Organic Framework Constructed from 2, 5-Thiophenedicarboxylate and Melamine Ligands: Catalysis Dye Degradation and Anti-tumor Activity in Myocardioma]  (Liu et al 2020; ling_ma**666**@163.com). 1, 4, 6, 7, 10, 11, 14 -  [Multifunctional Zinc Metalu2013Organic Framework for Highly Selective Detection of Picric Acid and Inhibition of Laryngeal Cancer Cell Growth]  (Wu Guo 2020; wenkui_wu1968@126.com). 1, 4, 8, 10 -  [Zn(II)-Containing Metalu2013Organic Framework for Fluorescence Detection of Nitrobenzene and Prevention Effect on Hypertension via Down-Regulating the Expression of Vitamin D Receptor]  (Wei et al 2020; yongxin_zhang**66**@sina.com). 1, 4, 7, 10, 12 -  [Development of two Cu(II) and Cd(II) coordination complexes based on mixed-ligand approach and application of their nanostructures as potential anti-breast cancer agents]  (Wang et al 2019; guangdong_you**666**@126.com). 4, 5, 6, 7, 9, 10, 11, 14 -  [Catalytic cyanosilylation application and antitumor activity in osteosarcoma of a porous Gd(III)-based coordination polymer]  (Wang Xue 2019; guibin_xue**66**@126.com). 1, 3, 4, 7, 8, 10, 13, 14 -  [Crystal structure, molecular docking and protective activity on myocarditis of Co(II) coordination polymer based nanoparticles]  (Bai et al 2020; qingshan_zhang**666**@163.com). 3, 4, 8, 10, 12 -  [Three novel Schiff base transition metal(II) complexes induce gastric cancer cell death through ROS-mediated apoptotic pathway]  (Qi et al 2019; qian_guo**666**@126.com). 1, 2, 4, 9, 10, 13 -  [Two Novel Ca(II)-Carboxylate Coordination Polymers: Crystal Structures and Antimyeloma Activity Evaluation]  (Liang et al 2019; an_tong**666**@126.com). 4, 5, 7, 9, 10, 11, 13, 14 -  [Effects of Substituent Groups on the Crystal Structures and Anti-Cervical Cancer Activity of Zero- Two-Dimensional Cu(II) Complexes]  (Li et al 2020; xia_wu1974@126.com). 3, 4, 6, 7, 10, 14 -  [Crystal Structure and Evaluation of the Anti-Gastric Cancer Activity of a New Sr(II)-Based Coordination Polymer]  (Han et al 2020; xitao_liu81@sina.com). 2, 3, 7, 8, 9, 10, 12 -  [A New Coordination Polymer Based on Two Dual-Functional Ligands: Structural Insights and Treatment Effect Against Inflammatory Metrorrhagia by Inhibiting NF-u03bab Activation and IL-1u03b2 Release]  (Ren, Fu Li 2020; haiming_ren1970@126.com). 3, 8, 10, 12 -  [Two new coordination polymers based on the 2,4,6-tri(1H-imidazol-1-yl)-1,3,5-triazine ligand: Structures and anticancer activity on human osteogenic sarcoma cell]  (Liu et al 2020; Liangbo_jiang1985@126.com). 4, 6, 7, 10, 11, 14 -  [Synthesis, structures and anticancer activities of two coordination polymers based on 1,4-bis((1H-benzo[d]imidazol-1-yl)methyl)benzene ligand]  (Han et al 2020; zhenfang_lin**666**@yeah.net). 4, 5, 6, 7, 9, 10, 11, 14 ------------------------------ - [1]. D. M. Chen, J. Y. Tian, Z. W. Wang, C. S. Liu, M. Chen, and M. Du (2017). Chem. Commun. 53, 10668.  An anionic Na(i)u2013organic framework platform: separation of organic dyes and post-modification for highly sensitive detection of picric acid - [2]. H. Du, C. Ma, W. Ma, and H. Wang. Process. Appl. Ceram., 2018, 12, 303  Microstructure evolution and dielectric properties of Ce-doped SrBi4Ti4O15 ceramics synthesized via glycine-nitrate process - [3]. C. Duan, J. Huo, F. Li, M. Yang, H. Xi, J. Mater. Sci. 53 (2018) 16276.  Ultrafast room-temperature synthesis of hierarchically porous metalu2013organic frameworks by a versatile cooperative template strategy - [4]. C. Duan, F. Li, M. Yang, H. Zhang, Y. Wu and H. Xi, Rapid Synthesis of Hierarchically Structured Multifunctional Metalu2013Organic Zeolites with Enhanced Volatile Organic Compounds Adsorption Capacity, Ind Eng Chem Res 57 (2018), 15385u201315394. - [5]. C. Duan, H. Zhang, F. Li, J. Xiao, S. Luo, and H. Xi. 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Synergistic Effect Between Nano-Sb2O3 and Brominated Epoxy Resin on the Flame Retardancy of Poly(butylene terephthalate) - [10]. Y.Y. Yang, L. Kang, H. Li, Ceram. Int. 45 (2019) 8017.  Enhancement of photocatalytic hydrogen production of BiFeO3 by Gd3+ doping - [11]. Y. Yang, H. Li, W. Zheng, Y. Bai, Z. Liu, J. Zhang, Sci. Adv. Mater. 11 (2019) 208.  Experimental study on calcining process of secondary coated ceramsite solidified chromium contaminated soil - [12]. L. Zhao, L. Kang, and S. Yao (2019). IEEE Access 7, 984.  Research and Application of Acoustic Emission Signal Processing Technology - [13]. H. Zhao, X. Mu, C. Zheng, S. Liu, Y. Zhu, X. Gao, T. Wu, Structural defects in 2D MoS2 nanosheets and their roles in the adsorption of airborne elemental mercury, J. Hazard Mater. 366 (2019) 240u2013249. - [14]. Y. Feng, H. Fan, Z. Zhong, H. Wang and D. Qiu, Cd3(MoO4)(TeO3)2: A Polar 3D Compound Containing d10u2013d0 SCALP-Effect Cations, Inorg Chem 55 (2016), 11987u201311992. ,