H19 Functions as a ceRNA in Promoting Metastasis Through Decreasing miR-200s Activity in Osteosarcoma
Authors: Shuming Gao
Min Li
Yuejiang Zhao
Hanwen Chen
Cai Cheng
Journal: DNA and Cell Biology (2016)
Discipline: MOLECULAR BIOLOGY & GENETICS
Keywords: Osteosarcoma; pulmonary metastasis; H19; migration; invasion
Affiliations: Department of Orthopedics, Cangzhou Central Hospital , Hebei, China .

Abstract:  Osteosarcoma is the most common primary bone sarcoma around the world. The poor prognosis and high recurrence rate of osteosarcoma are largely due to the high rate of pulmonary metastasis. H19 has been reported to play a potential role in osteosarcoma progression. However, the exact molecular mechanism of metastasis involving H19 remains unclear. In the present study, we performed gain- and loss-of-function assays and found that H19 promotes migration and invasion in osteosarcoma cells. Furthermore, we showed that H19 promotes metastasis through upregulation of ZEB1 and ZEB2 by competitively binding the miR-200 family. Thus, our findings suggest important roles of H19 in osteosarcoma metastasis and indicate its potential application in osteosarcoma therapy. 

Retracted: Yes

PubPeer comments:
 It appears that multiple images in Figure 1A-E (left) and Figure 4A-B overlap with others. This type of issue is sometimes seen in papers that have been outsourced. *** ![file] , 
 Potentially supporting the concern that this paper may have been outsourced to a third party, one image in Figure 4B seems to overlap with an image Figure 4B of another paper: Biomedicine Pharmacotherapy (2018), doi: 10.1016 j.biopha.2017.12.114, discussed here: https: pubpeer.com publications 29A07BD9E3F27454B5AF867A937210. The Biomedicine Pharmacotherapy paper seems to share data with two other papers too. Hmm. *** ![file] , 
 https: doi.org 10.1089 dna.2015.3171.retract Published Online: 4 Mar 2022 The Editor-in-Chief of DNA and Cell Biology officially retracts the article entitled, u201cH19 Functions as a ceRNA in Promoting Metastasis Through Decreasing miR-200s Activity in Osteosarcoma,u201d by Min Li, Hanwen Chen, Yuejiang Zhao, Shuming Gao, and Cai Cheng (DNA Cell Biol 35(5):235u2013240; doi: 10.1089 dna.2015.3171) after receiving alerts from the PubPeer platform 1 and comments on Twitter 2 regarding multiple image duplications between Figure 1A-E and Figure 4A-B, and also with a separately published manuscript from a different author group (Figure 4B). 3 The journal publisher independently confirmed the suspected duplications. The corresponding author of the paper, Dr. Min Li, along with all co-authors, were contacted for an explanation but no response was received. DNA and Cell Biology is committed to upholding the rigors of scientific publishing and the veracity of the literature. --------------------------- References 1. PubPeer. Actinopolyspora biskrensis. https: pubpeer.com publications 717BB701CF9D81B2CF74F636201C22 2. Twitter. @Thatsregrettab1. https: twitter.com Thatsregrettab1 status 1498715251247775747 3. Zhao D, Jiang Z, Wang Z, Gao J. Retinoid interferon-induced mortality19 (GRIM19) inhibits proliferation and invasion in rheumatoid arthritis fibroblast-like synoviocytes. Biomed Pharmacother 2018;98:719-725; doi: 10.1016 j.biopha.2017.12.114 ,