Circular RNA hsa_circ_0000285 acts as an oncogene in laryngocarcinoma by inducing Wnt/β-catenin signaling pathway
Authors: J-B Qin
W Chang
L Huang
Z-F Qiu
G-H Yuan
Journal: European review for medical and pharmacological sciences (2019)
Discipline: PHARMACOLOGY & TOXICOLOGY
Keywords: Laryngocarcinoma; circRNAs; hsa_circ_0000285; RT-qPCR; cell proliferation
Affiliations: Department of Otolaryngology Head and Neck Surgery, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China. .

Abstract:  Objective: Laryngocarcinoma is one of the most ordinary head and neck cancers worldwide. Recent studies have revealed that circular RNAs (circRNAs) act as an important role in malignant tumors and participate in tumorigenesis. The purpose of our work is to uncover how hsa_circ_0000285 functions in laryngocarcinoma. Patients and methods: In this research, the Real Time-quantitative Polymerase Chain Reaction (RT-qPCR) was performed to monitor hsa_circ_0000285 expression in laryngocarcinoma samples. Besides, function assays were performed in laryngocarcinoma cells transfected with hsa_circ_0000285 shRNA or lentivirus. Furthermore, the RT-qPCR and Western blot assay were conducted to explore the target-signaling pathway of hsa_circ_0000285. Results: Hsa_circ_0000285 expression was found to be upregulated in laryngocarcinoma samples compared with adjacent tissues. The function assays showed that the inhibition of the cell proliferation was induced via knockdown of hsa_circ_0000285 in laryngocarcinoma in vitro, while the promotion of cell apoptosis was induced via the knockdown of hsa_circ_0000285 in laryngocarcinoma in vitro. On the other hand, the overexpression of hsa_circ_0000285 had the opposite function. In addition, the Wnt/β-catenin signaling pathway was repressed via knockdown of hsa_circ_0000285 in laryngocarcinoma, while the Wnt/β-catenin signaling pathway was promoted via overexpression of hsa_circ_0000285 in laryngocarcinoma. Conclusions: In our study, hsa_circ_0000285 was first identified as a novel oncogene and could induce the Wnt/β-catenin signaling pathway in laryngocarcinoma. 

Retracted: Yes

PubPeer comments:
 This paper is one of a set of 121 papers that all contain images from the same library of about 100 photos and plots. This is unexpected, because each paper has different authors and different affiliations, with little to no overlap, and describes different cancer types and molecules. It would be very hard to explain how authors from different labs would all obtain the same photo. Therefore, the papers might have all be derived from the same source, such as a paper mill that sells ready-to-be-published papers. This  Stock Photo paper set has been described in more detail on my blog post, https: scienceintegritydigest.com 2020 07 05 the-stock-photo-paper-mill and in a Wall Street Journal article by Eva Xiao (currently behind a paywall): https: www.wsj.com articles chinese-research-papers-raise-doubts-fueling-global-questions-about-scientific-integrity-11593939600 The vast majority (113 121) of the papers were published in the same journal, European Review for Medical and Pharmacological Sciences (ERMPS). A link to the full set of papers can be found here: https: docs.google.com spreadsheets d 172RWS18w1lTNJ9Nnj80fuXXTqTm4fGkoK0sdYyvKE3g edit?usp=sharing All papers have been reported to the journal editors on July 2, 2020. , 
 Withdrawn. https: www.europeanreview.org article 23169 *Since this article has been suspected of research misconduct and the corresponding authors did not respond to our request to prove originality of data and figures, u201cCircular RNA hsa_circ_0000285 acts as an oncogene in laryngocarcinoma by inducing Wnt u03b2-catenin signaling pathway, by J.-B. Qin, W. Chang, G.-H. Yuan, L. Huang, Z.-F. Qiu, published in Eur Rev Med Pharmacol Sci 2019; 23 (24): 10803-10809u2013DOI: 10.26355 eurrev_201912_19783u2013PMID: 31858548u201d has been withdrawn.* *The Publisher apologizes for any inconvenience this may cause.* , 
 http: www.most.gov.cn zxgz kycxjs kycxgzdt 202201 t20220127_179206.html Google Translated Date: January 27, 2022 14:44 Source: Ministry of Science and Technology u3000u300021. The paper  Circular RNA hsa_circ_0000285 acts as an oncogene in laryngocarcinoma by inducing Wnt u03b2-catenin signaling pathway by Qin Jiangbo of Peace Hospital Affiliated to Changzhi Medical College as the corresponding author and the first author. After investigation, the paper has falsified data and fabricated results. Qin Jiangbo will be dealt with as follows: order to withdraw the manuscript, give him an administrative warning, cancel his qualification to undertake financial support projects for 5 years, and cancel his qualifications for participating in scientific research awards, scientific and technological talent recommendation and selection, evaluation of excellence, and promotion of professional titles for 1 year. u3000u3000(Notification link: http: kjb.czmc.com info 1007 1782.htm) ,