Recent perspectives of epithelial ovarian carcinoma
Authors: Pei-Ying Zhang
Xiao-Ying Zhang
Journal: Oncology Letters (2016)
Discipline: CLINICAL MEDICINE
Keywords: epithelial ovarian carcinoma; gynecological cancer; resistance; therapeutic avenues.
Affiliations: Nanjing University of Chinese Medicine, Information Institute, Nanjing, Jiangsu 221009, P.R. China., Department of Cardiology, Xuzhou Central Hospital, The Affiliated Xuzhou Hospital of Medical College of Southeast University, Xuzhou, Jiangsu 221009, P.R. China.

Abstract:  Epithelial ovarian tumours have been reported to mainly arise from the simple cuboidal surface epithelium of the ovary, and account for 75% of all ovarian tumours, and 90-95% of ovarian malignancies. Epithelial ovarian carcinoma (EOC) is responsible for the highest number of deaths in women due to gynecologic malignancy, with a low 5-year relative survival of only 44%. The possible reasons for these low survival rates are the high incidence of chemoresistance found with EOC and a lack of consideration of the high degree of heterogeneity of EOC in the current standard of care. The present review highlights the recent perspectives of EOC including screening strategies of EOC, current therapeutic regimens for EOC and the recent strategies in pipeline in order to improve therapeutics for EOC. We searched the electronic database PubMed for pre-clinical as well as clinical controlled trials reporting diagnostic as well as therapeutic advances against epithelial ovarian cancer. It was observed that great effort is applied in research for the development of both highly efficient diagnostic as well as therapeutic strategies against EOC. 

Retracted: Yes

PubPeer comments:
 This review paper appears to be unexpectedly similar to a 2014 PhD thesis by Miow Qing Hao at the National University of Singapore called  Identification of Functional targets in Epithelial Ovarian Cancer . That thesis can be found here: https: core.ac.uk download pdf 48735866.pdf Here is a marked-up version of the text by Zhang and Zhang 2016, with highlighted text showing similarities to the Miow Qing Hao 2014 thesis. Generated in SimTexter : ![file] ![file] ![file] , 
 Retracted [1 September 2020] . --------------------------------------------- Following the publication of this article, an interested reader drew to our attention that the flow of the text, and the wording of numerous passages of text within the article, bore striking and unexpected similarities to the wording employed in a PhD thesis by Miow Qing Hao at the National University of Singapore in 2014 entitled u201cIdentification of Functional Targets in Epithelial Ovarian Canceru201d. After having conducted an internal investigation, the Editor of Oncology Letters has determined beyond all reasonable doubt that the review submitted to the Journal shared an unacceptable level of identity with the PhD thesis by Miow Qing Hao. The authors were contacted about these apparent similarities between their review and the thesis, although they failed to respond to our query in this regard. The Editor of Oncology Letters deeply regrets that this article was not intercepted by our own checks for plagiarism prior to the publication of the review, and sincerely apologizes to the author of the PhD thesis and the readership for the inconvenience caused. We also thank the reader for bringing this matter to our attention. ,