CVD-grown monolayer MoS in bioabsorbable electronics and biosensors
Authors: Gayoung Park
Minpyo Kang
Matthew R MacEwan
Yong Ju Park
Kyung-Mi Lee
Wilson Z Ray
Ying Yan
Sachin M Shinde
John A Rogers
Jong-Hyun Ahn
Seung-Kyun Kang
Jahyun Koo
Jiho Shin
Xiang Chen
Seunghyun Jeon
Journal: Nature communications (2018)
Discipline: Multidisciplinary
Keywords: Transient electronics; 2D materials; bioabsorption; CVD-grown monolayer MoS2; cytotoxicity
Affiliations: School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seoul, 03722, Republic of Korea., Department of Bio and Brain Engineering, KI for Health Science and Technology (KIHST), Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea., Department of Materials Science and Engineering, Northwestern University, Evanston, 60208, IL, USA., Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA., Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, 02841, Republic of Korea., Department of Neurological Surgery, Washington University School of Medicine, St Louis, MO, 63110, USA., Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, 02841, Republic of Korea. ., Department of Materials Science and Engineering, Northwestern University, Evanston, 60208, IL, USA. ., Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. ., Departments of Biomedical Engineering, Chemistry, Mechanical Engineering, Electrical Engineering and Computer Science, Center for Bio-Integrated Electronics, Simpson Querrey Institute for Nano/Biotechnology, Northwestern University, Evanston, IL, 60208, USA. ., School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seoul, 03722, Republic of Korea. .

Abstract:  Transient electronics represents an emerging technology whose defining feature is an ability to dissolve, disintegrate or otherwise physically disappear in a controlled manner. Envisioned applications include resorbable/degradable biomedical implants, hardware-secure memory devices, and zero-impact environmental sensors. 2D materials may have essential roles in these systems due to their unique mechanical, thermal, electrical, and optical properties. Here, we study the bioabsorption of CVD-grown monolayer MoS2, including long-term cytotoxicity and immunological biocompatibility evaluations in biofluids and tissues of live animal models. The results show that MoS2 undergoes hydrolysis slowly in aqueous solutions without adverse biological effects. We also present a class of MoS2-based bioabsorbable and multi-functional sensor for intracranial monitoring of pressure, temperature, strain, and motion in animal models. Such technology offers specific, clinically relevant roles in diagnostic/therapeutic functions during recovery from traumatic brain injury. Our findings support the broader use of 2D materials in transient electronics and qualitatively expand the design options in other areas. 

Retracted: No

PubPeer comments:
 In Figure 3b it seems that there is a possible image duplication (part of the filed of view at least). You can see here the original figure and the zoomed panels, one representing  None condition and the other representing  MoS2 condition.![file] ,