A New Eucalyptol-Rich Lavender (Lavandula stoechas L.) Essential Oil: Emerging Potential for Therapy against Inflammation and Cancer
Authors: Shaker A Mousa
Mehdi Rajabi
Aicha Houche
Thangirala Sudha
Fatma Benkebailli
Mohamed Nadjib Boukhatem
Asma Belkadi
Faiza Oudjida
Henni Chader
Noureldien H E Darwish
Journal: Molecules (2020)
Discipline: CHEMISTRY
Keywords: 1,8-Cineole; Lavandula stoechas essential oil; anticancer activity; melanoma cell lines; topical anti-inflammatory effect.
Affiliations: The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Rensselaer, New York, NY 12144, USA., Département de Biologie et Physiologie Celulaire, Faculté des Sciences de la Nature et de la Vie, Université-Saad Dahlab-Blida 1, Blida 09000, Algeria., Hematology Unit, Clinical Pathology Department, Mansoura Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt., Laboratoire de Pharmaco-Toxicologie, Laboratoire National de Contrôle des Produits Pharmaceutiques (LNCPP), Dely-Ibrahim, Algiers 16047, Algeria., Faculté de Médecine-Université Ben Youcef Ben Khedda-Alger I, Algiers 16000, Algeria., Laboratoire Pharmaco-Toxicologie, Centre de Recherche & Développement Saidal, Algiers 16004, Algeria., Laboratoire d'Anatomie Pathologique, Centre Hospitalo-Universitiare de Beni-Messous, Algiers 16206, Algeria.

Abstract:  Background/aim: natural products are a potential source for drug discovery and development of cancer chemoprevention. Considering that drugs currently available for the treatment of inflammatory and cancer conditions show undesirable side effects, this research was designed to evaluate, for the first time, the in vitro anticancer activity of Algerian Lavandula stoechas essential oil (LSEO) against different cancer cell lines, as well as its in vitro and in vivo topical and acute anti-inflammatory properties. Materials and methods: the LSEO was extracted by steam distillation, and chemical composition analysis was performed using gas chromatography. The main compounds identified in LSEO were oxygenated monoterpenes, such as 1,8-Cineole (61.36%). LSEO exhibited a potent anti-inflammatory activity using the xylene-induced mouse ear edema model. Results: LSEO (200 and 20 mg/kg) was able to significantly reduce (p &lt; 0.05) the carrageenan-induced paw edema with a similar effect to that observed for the positive control. Topical application of LSEO at doses of 82 and 410 mg/kg significantly reduced acute ear edema in 51.4% and 80.1% of the mice, respectively. Histological analysis confirmed that LSEO inhibited the skin inflammatory response. Moreover, LSEO was tested for its antitumor activity against different cancer cell lines. LSEO was found to be significantly active against human gastric adenocarcinoma (AGS), Melanoma MV3, and breast carcinoma MDA-MB-231 cells, with median inhibitory concentration (IC50) values of 0.035 ± 0.018, 0.06 ± 0.022 and 0.259 ± 0.089 µL/mL, respectively. Altogether, these results open a new field of investigation into the characterization of the molecules involved in anti-proliferative processes. Conclusion: We suggest that LSEO, with 1,8-Cineole as the major active component, is a promising candidate for use in skin care products with anti-inflammatory and anticancer properties. The results of this study may provide an experimental basis for further systematic research, rational development, and clinical utilization of lavender resources. 

Retracted: No

PubPeer comments:
 Two studies, the same Ethic Comitee number : https: doi.org 10.3390 cancers13092169 and https: doi.org 10.3390 cancers13133335 The numbers and the results of the two studies have significant overlaps. , 
 Dear Colleague Thank you for your interest in our articles. It is obvious for anyone reading the two studies that these articles are originating from the same project on a large chordoma series. These two studies are impossible to publish in the same paper: the two works have different aims, with different antibodies methodology used to answer the questions, and of course with different results. Besides, we do mention three times in the first published article (10.3390 cancers13092169), the other work (still under submission at that time). Best regards Georgia Karpathiou Michel Pu00e9oc h ,