Retracted: Cardiac release of urocortin precedes the occurrence of irreversible myocardial damage in the rat heart exposed to ischemia/reperfusion injury
Authors: Zhaokan Yuan
Tiziano M Scarabelli
Anastasis Stephanou
Carol Chen-Scarabelli
Alessandro Mazzucco
Giuseppe Faggian
Roy B McCauley
Richard A Knight
Paul A Townsend
David Latchman
Louis Saravolatz
Hardial S Chowdrey
J Di Rezze
Gabriele M Scarabelli
Journal: FEBS Letters (2008)
Discipline: BIOLOGY & BIOCHEMISTRY
Keywords: cardiac ischemia; urocortin; myocyte cell death; apoptosis; necrosis
Affiliations: Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom.  <>

Abstract:  This study evaluates whether cardiac ischemia induces release of urocortin, before and independently from myocyte cell death. Urocortin levels rose after 5-min ischemia and peaked after 10-min ischemia, when cell death was not detected. However, myocyte apoptosis and/or necrosis occurred following 20- and 30-min ischemia, which paralleled a fall in urocortin levels, suggesting that urocortin expression and release are mainly sustained by metabolically challenged, though still viable myocytes. Hence, since cardiac release of urocortin, unlike that of conventional biomarkers, occurs before and apart from cell death, urocortin levels may be clinically useful in the diagnosis of sublethal myocardial ischemia. 

Retracted: Yes

PubPeer comments:
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 2018 retraction notice. https: febs.onlinelibrary.wiley.com doi abs 10.1002 1873-3468.13014  FEBS Letters, Volume 582, Issue 6, Pages 984u2013990 DOI: 10.1016 j.febslet.2008.02.035 The above article from FEBS Letters, published online on February 22, 2008 in Wiley Online Library (http: wileyonlinelibrary.com), has been withdrawn by agreement between the authors, the Journal Managing Editor Felix Wieland, and John Wiley Sons Ltd., on behalf of the Federation of European Biochemical Societies. The retraction has been agreed following an initial investigation from the University College London that found clear signs of manipulation in Figures 1, 3, and 5. A subsequent investigation by the journal s Editorial Office with the assistance of an image integrity analyst corroborated these findings.  https: retractionwatch.com 2018 03 19 clear-signs-of-manipulation-in-paper-co-authored-by-prominent-geneticist , 
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 Itu2019s so disappointing that Wiley donu2019t use **red stencils** for the Retracted overlay. Even so, it is good to see this piece of fiction - with itu2019s overlapping yet outrageously manipulated bits of u201cheartu201d - is now retracted. Itu2019s also a bit disappointing that the retraction text is opaque about who did what. However, we can probably infer that those who had never worked in that UCL lab did not bodge the figures. ![image] The Masteru2019s group has been under investigation since 2013. It surely could have gone faster. But as it happens, 2018 is looking like a very special year for UCL which, as you well know, fancies itself to be the UKu2019s research powerhouse. Will 2018 bring a perfect storm? Thus, for Harry Potter fans, there is a fascinating parallel to the Hogwarts u201croom of requirementu201d. For there is a special room in UCL at the end of a very long corridor and entirely unbeknown to senior management. This room perfectly meets the requirements for white supremacist get togethers, such that a Danish neo-Nazi paedophile may consort happily with a eugenicist English education czar. http: londonstudent.coop news 2018 01 10 exposed-london-eugenics-conferences-neo-nazi-links And then there is the as yet unresolved issue of the scalpel-wielding Macchiarini Mini-Meu2019s and their hopeless quest to fix damaged tracheae by throwing stem cells onto dead bits of gristle. Niche? What niche? As any fule kno, there is no niche on dead gristle. Perhaps to compensate, there is serial image duplication in the papers https: forbetterscience.com 2017 12 27 image-reuse-the-new-low-of-ucl-trachea-transplanter-martin-birchall , 
 https: www.buzzfeednews.com article peteraldhous david-latchman-scientific-misconduct , 
 #21 Thank you for posting that link to the article which links to the redacted summary of the investigations. The first of the three investigations appears to have diligently sought original data for the papers listed in the 2013 complaint. It turned out that there was **ZERO DATUM** available prior to 2010. Only three years before the allegations were sent in :-( This FEBS Letts paper was fingered by Peer 1 in 2015 so was presumably examined in a later investigation as outside the remit of the first panel. But, as the first investigation explains, there would not have been any data before 2010 anyway: Which is only **two years after publication** of this paper. Overlaid on the retraction image below are excerpts from the first investigation. Remember that the panel was *not allowed to look beyond the original allegations*: Even as other papers were being routinely flagged up at PubPeer. But they did try to warn utGRP (ucl, the Global Research Powerhouse) that u201cthis might be just the tip of the icebergu201d. Which, we now know, it was. And, as we now also know, utGRP knows this too. ![image] ,