TWO NEW Co(II)-BASED COORDINATION POLYMERS:STRUCTURAL CHARACTERIZATION AND PROTECTIVEEFFECT ON PARKINSON DISEASE BY IMPROVINGTHE CONTENT OF DOPAMINE IN THE SUBSTANTIA NIGRA
Authors: Wen, X. -Q.
Yue, F. -L.
Cui, C. -F.
Wang, X.
Ma, S. -B.
Sang, C. -N.
Journal: Journal of Structural Chemistry (2020)
Discipline: CHEMISTRY
Keywords: Coordination polymers; 5-aminoisophthalic acid; 1,2-bis(4-pyridyl)ethylene; Co(II) salt; solvothermal reaction

Abstract: Two new mixed-ligand coordination polymers with the chemical formulae {[Co(5-amipa)(bpe)]DMF}n (1, H2amipa&nbsp;=&nbsp;5-aminoisophthalic acid, bpe&nbsp;=&nbsp;1,2-bis(4-pyridyl)ethylene, DMF&nbsp;=&nbsp;dimethylformamide) and {[Co(5-amipa)(bpe)](DMA)}n (2, DMA&nbsp;=&nbsp;dimethylacetamide) are successfully synthesized by the solvothermal reaction of 5-aminoisophthalic acid and the N-donor 1,2-bis((4-pyridyl)ethylene) co-ligand with Co(II) salt in different solvent systems. All compounds are adequately characterized, and their structures are verified by single crystal X-ray diffraction along with the elemental analysis. Furthermore, the protective effect of compounds 1 and 2 on Parkinson disease is evaluated in the biological function section. Firstly, the ELISA detection is performed to estimate the dopamine content in the substantia nigra after treatment with the compounds. Then the open field test is finished to reflect the treatment ability of the compounds on the cognitive ability of mice.

Retracted: No

PubPeer comments:
 This paper appears to have been written by following a template, populating the  Citation slots with a short list of recycled references that appear in dozens of other papers from the same production line.  Parkinson disease is one of the most common neurodegenerative diseases, with the character of slowness and paucity of movement (bradykinesia), muscle rigidity, resting tremors, and disordered posture [1]. - [1]. S. Humphries, N. Klooster, E. Cardillo, D. Weintraub, J. Rick, and A. Chatterjee. Cortex, 2019, 121, 362.  From action to abstraction: The sensorimotor grounding of metaphor in Parkinsonu2019s disease  Within the 10th to 25th years of initial symptoms, the character of Parkinson patients will slow progress to akinesia, severe tremors, physical disability, and even death [2]. - [2]. C. M. Koopman, E. Lutters, J. Nonnekes, B. R. Bloem, J. P. P. Vugt, and M. C. Tjepkema-Cloostermans. Parkinsonism Relat. Disord, 2019, 69, 59. * Vibrating socks to improve gait in Parkinson s disease *  In the USA, there is approximately 1% of Americans affected with Parkinson disease above the age of 60 years. However, the detailed mechanism of Parkinson disease has been unknown, but the researchers have revealed that usually there was a loss of dopamine-containing neurons in the substantia nigra pars compacta of the brainstem and disruption of normal dopaminergic neurotransmission [3, 4]. - [3]. W. Chen, L. Chang, S. B. Ren, Z. C. He, G. B. Huang, and X. H. Liu. J. Hazard. Mater., 2020, 384, 121308. ** Direct Z-scheme 1D 2D WO 2.72 ZnIn 2 S 4 hybrid photocatalysts with highly-efficient visible-light-driven photodegradation towards tetracycline hydrochloride removal ** - [4]. J. Su, Z. Sheng, V. C. M. Leung, and Y. Chen. IEEE Wireless Commun., 2019, 26, 118. ** Energy Efficient Tag Identification Algorithms For RFID: Survey, Motivation And New Design **  Now, more and more researchers are interested in Parkinson disease treatment and improvement of the quality of life and survival [5]. - [5]. J. Zhao, M. Xin, J. Zhang, Y. Sun, S. Luo, H. Wang, Y. Wang, and X. Bi. Chemosphere, 2020, 243, 125380. ** Diclofenac inhibited the biological phosphorus removal: Performance and mechanism **  The design and synthesis of coordination polymers (CPs) have attracted uprising research interest not only due to their structural and topological novelty but also owing to their tremendous potential applications in gas storage, chemical separations, ion exchange, microelectronics, nonlinear optics, and heterogeneous catalysis [6-10]. - [8]. D. Liu, C. Ding, F. Chi, N. Pan, J. Wen, J. Xiong, and S. Hu. J. Appl. Polym. Sci., 2019, 136, 48156. ** Polymer brushes on graphene oxide for efficient adsorption of heavy metal ions from water ** - [9]. Y. Zeng, L. Xie, F. Chi, D. Liu, H. Wu, N. Pan, and G. Sun. Macromol. Rapid Commun., 2019, 40, 1900078 ** Controlled Growth of Ultra-Thick Polymer Brushes via Surface-Initiated Atom Transfer Radical Polymerization with Active Polymers as Initiators ** - [10]. F. Chi, D. Liu, H. Wu, and J. Lei. Sol. Energy Mater. Sol. Cells, 2019, 200, 109939. ** Mechanically robust and self-cleaning antireflection coatings from nanoscale binding of hydrophobic silica nanoparticles ** , 
 According to Table 1, the crystal-structure determination data and parameters for the present compounds are in the CCDC database with Deposition Number [1963688] , [1963689] . The CCDC database informs me that these datasets were deposited by Meng Qinghua, of Hang Zhou University. By my reckoning, [Meng Qinghua has deposited 118 crystal structures with CCDC] . Most of them became parts of problematic papers by otherwise-unrelated teams of authors, including this one. , 
 Deposited structures [CCDC-1963688] (BUCVUT) and CCDC-[1963689] (SAJLAU) were copied from a *Journal of solid State Chemistry* [article](http: dx.doi.org 10.1016 j.jssc.2019.120933) published in 2019 and reporting on similar MOFs: see refcodes in the CCDC, including structure factors, [POQMEQ] and [POQNAN] , respectively. Note how formulas were slightly modified, by substituting a NH2 group by a CH3 group, changing the transition metal and the lattice solvent. I m afraid that the reported  new Co(II) compounds have absolutely no effect on the content of dopamine in the substantia nigra. These researchers are just wannabes. ![file] ![file] ,