RETRACTED: Physcion 8-O-β-glucopyranoside inhibits clear-cell renal cell carcinoma bydownregulating hexokinase II and inhibiting glycolysis
Authors: Fawei Qin
Yong Wang
Jie Zhang
Peng Guo
Yi Yan
Qiang Wang
Yuqing Xing
Qingyun Zeng
Journal: Biomedicine & Pharmacotherapy (2018)
Discipline: PHARMACOLOGY & TOXICOLOGY
Keywords: Apoptosis; Glycolysis; HK2; PG; ccRCC.
Affiliations: Shandong Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China., Hospital Affiliated to Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China. Electronic address: .

Abstract:  This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief and the authors. Panels from Figure 2A appear similar to panels from Figure 3A of the article published by Xiangyang Dou, Meihua Wang, Tao Zhang and Jiapei Yao in The Anatomical Record (2019) https://doi.org/10.1002/ar.24324, Figures 2B and 6B of the article published by C.-L. Xue, H.-G. Liu, B.-Y. Li, S.-H. He and Q.-F. Yue in the Eur. Rev. Med. Pharmacol. Sci. 23 (2019) 5101-5112 https://doi.org/10.26355/eurrev_201906_18174 and Figure 3B of the article published by Bo Liu and Shuo Yu in Biomedicine &amp; Pharmacotherapy 107 (2018) 243-253 https://doi.org/10.1016/j.biopha.2018.07.177. Panels from Figure 6D appear similar to panels from Figure 8D of the article published by The Anatomical Record (2019) https://doi.org/10.1002/ar.24324, Figure 7E of the article published by Ying Niu, Jinping Zhang, Yalin Tong, Jiansheng Li and Bingrong Liu in Life Sciences 237 (2019) 116893 https://doi.org/10.1016/j.lfs.2019.116893 and Figure 7F of the article published by Xiaoping Pan, Chen Wang, Yan Li, Lida Zhu and Ti Zhang in Life Sciences 214 (2018) 124-135 https://doi.org/10.1016/j.lfs.2018.10.064. Although this article was published earlier than the other articles, the Editor decided to retract this article given concerns about the reliability of the data. 

Retracted: Yes

PubPeer comments:
 Below: Fig 2A. Above: Fig 3A from [Dou et al (2019)] . Similar panel is marked. ![] As noted by Xylocampa Areola, the same panel also appears in [Xue et al (2019)] . Physcion 8-O-u03b2-glucopyranoside is magical! ![] , 
 Figure 2D. ![file] , 
 #1 Would it come as too great a surprise that Physcion 8-O-u03b2-glucopyranoside can also manifest as Amentoflavone? Fig 3B from [Liu Yu (2018)] ,  Amentoflavone suppresses hepatocellular carcinoma by repressing hexokinase 2 expression through inhibiting JAK2 STAT3 signaling : ![] Below: Fig 2A. Above: Fig 3A from Dou et al (2019): ![] , 
 Here are galleries of histology slices from four papers, with four non-overlapping teams of nominal authors, sharing surprisingly many slices in common. Identication of each slice in terms of teatment and immunohistochemistry stain is arbitrary. There may well be more duplicates but I lost interest when I ran out of colors. Upper left: Fig 6D from [Wang et al (2018)] . Physcion 8-O-u03b2-glucopyranoside and clear-cell renal cell carcinoma. Middle left: 8D from [Dou et al (2019)] . Physcion 8-O-u03b2-Glucopyranoside and Testicular Germ Cell Tumors. Upper right: 7E from [Niu et al (2019)] . Physcion 8-O-u03b2-glucopyranoside and gastric cancer. Lower: 6C from [Zou et al (2018)] . Euxanthone and epithelial ovarian cancer. ![] , 
 Here are galleries of histology slices from **six** papers, with **six** non-overlapping teams of nominal authors, sharing surprisingly many slices in common. Identication of each slice in terms of treatment and immunohistochemistry stain is arbitrary. Focussing on connections to the uppermost image, due to lack of colors to show other inter-relationships. Clockwise from top: Fig 7F from [Pan et al (2018)] . Physcion and hepatoceullar carcinoma. 7E from [Niu et al (2019)] . Physcion 8-O-u03b2-glucopyranoside and gastric cancer. Fig 6D from [Wang et al (2018)] . Physcion 8-O-u03b2-glucopyranoside and clear-cell renal cell carcinoma. 6C from [Zou et al (2018)] . Euxanthone and epithelial ovarian cancer. 8C from [Liu et al (2018)] . Hispidulin and colorectal cancer. 8D from [Dou et al (2019)] . Physcion 8-O-u03b2-Glucopyranoside and Testicular Germ Cell Tumors. ![] , 
 Below: Fig 6D ,  [PG] increased apoptosis and decreased HK2 expression in tumor tissue. Above, Fig 7D from [Li et al (2019)] ,  Representative pictures of IHC staining for Ki-67, cleaved caspase-3, Bcl-2, Bax and RAD51 in the xenograft tumor tissues . ![file] , 
 Retracted [February 2021] . ----------------------------------------------- This article has been retracted at the request of the Editor-in-Chief, Editor-in-Chief and the authors. Panels from Figure 2A appear similar to panels from Figure 3A of the article published by Xiangyang Dou, Meihua Wang, Tao Zhang and Jiapei Yao in The Anatomical Record (2019) https: doi.org 10.1002 ar.24324, Figures 2B and 6B of the article published by C.-L. Xue, H.-G. Liu, B.-Y. Li, S.-H. He and Q.-F. Yue in the Eur. Rev. Med. Pharmacol. Sci. 23 (2019) 5101u20135112 https: doi.org 10.26355 eurrev_201906_18174 and Figure 3B of the article published by Bo Liu and Shuo Yu in Biomedicine Pharmacotherapy 107 (2018) 243u2013253 https: doi.org 10.1016 j.biopha.2018.07.177. Panels from Figure 6D appear similar to panels from Figure 8D of the article published by The Anatomical Record (2019) https: doi.org 10.1002 ar.24324, Figure 7E of the article published by Ying Niu, Jinping Zhang, Yalin Tong, Jiansheng Li and Bingrong Liu in Life Sciences 237 (2019) 116,893 https: doi.org 10.1016 j.lfs.2019.116893 and Figure 7u2009F of the article published by Xiaoping Pan, Chen Wang, Yan Li, Lida Zhu and Ti Zhang in Life Sciences 214 (2018) 124u2013135 https: doi.org 10.1016 j.lfs.2018.10.064. Although this article was published earlier than the other articles, the Editor decided to retract this article given concerns about the reliability of the data. ,