RETRACTED ARTICLE: Omega-3 fatty acid levels in red blood cell membranes and physical decline over 3¬†years: longitudinal data from the MAPT study
Authors: Sophie Peiffer
C√©cile Laubarie-Mouret
Catherine Burdet
Lynda Touati
Alain Pesce
Fran√ßois Cotton
St√©phane Chanalet
Fran√ßoise Lala
Marie-Laure Pader
Bertrand Foug√®re
Sherry Willis
Pierre-Jean Ousset
H√©l√®ne Villars
Fran√ßois Chollet
Fran√ßoise Hugon
Jean-Pierre Cl√©ment
Laurence Bernard-Bourzeix
Isabelle Saulnier
Laurent Molinier
Sabine Goisser
Charlotte Dupuy
S√©bastien Gonfrier
Pierre Payoux
Fleur Delva
Ga√´lle Soriano
Emeline Combrouze
Marie Chupin
Bertrand Perret
Isabelle Carri√©
Sophie Guyonnet
Corinne Costes
Colette Blatge
Yves Rolland
Sylvie Chaillou
H√©l√®ne Derumeaux
St√©phane Leh√©ricy
Franck Le Duff
Jean-Fran√ßois Lefebvre
Isabelle Marcet
Audrey Zueras
Patrick Manckoundia
Alain Bonaf√©
Sylvie Belleville
Jacques Darcourt
Fabrice Bonneville
Laur√©ane Brigitte
Carole Badufle
Jean-Fran√ßois Dartigues
Bruno Vellas
Evelyne Franon
Pascale Olivier-Abbal
Gabor Abellan Van Kan
Christophe Cognard
Jean-Pierre Salles
Audrey Gabelle
Francine Fontaine
Lawrence Bories
Nad√®ge Barro-Belaygues
Christine Malick-Loiseau
Bruno Lapoujade
Jacques Touchon
Claire Vinel
Aur√©lia Romano
Claire G√©d√©on
Julien Delrieu
Carole Dufouil
Nicolas Lebrun
Marie-Agn√®s Picat
C√©line Caillaud
Marie-France Basset
Michel Zanca
Val√©rie Quipourt
Dani√®le Begorre
Kristel Sudres
Sandrine Cerda
Ali Bouhayia
Jacques Monteil
Sophie Marilier
Mich√®le Allard
Fran√ßoise Desclaux
Jean-Fran√ßois Mangin
Sandrine Louchart
C√©cilia Marelli
Catherine Faisant
Pascale Rebaudet
Nad√®ge Costa
Michael Li Yung Tong
Flavien Terracol
Thierry Voisin
Karim Bennys
Marie-No√´lle Cuffi
No√´lle Cardinaud
Evelyne Cazaban-Campistron
Marie Paule Bonceour Martel
Christian Vincent
Christian Carpuat
Philipe De Souto Barreto
Matteo Cesari
Pierre Skolil
Serge Bordes
St√©phanie Willebois
Christophe Morin
Il√©ana D√©sormais
Olivier Rouaud
Anne Hitzel
Brigitte Gilbert
Val√©rie Faure
Yannick Gasnier
Philippe Robert
Samira Misbah El Idrissi
Claire Gervais
MAPT Study Group
Alexandra Foubert
Thierry Dantoine
Fr√©d√©ric Ricolfi
St√©phanie Roth
Christelle Cantet
Dominique Dubois
Sandrine Andrieu
Khaled Khales
Pierre Livet
C√©cile Pays
Marc Bonnefoy
Journal: GeroScience (2017)
Discipline: CLINICAL MEDICINE
Keywords: Gait speed; MAPT; Omega-3 polyunsaturated fatty acids; Physical performance; SPPB.

Abstract:  Studies have shown that omega-3 polyunsaturated fatty acids (PUFAs) are associated with brain, cardiovascular, and immune function, as well as physical performance and bone health in older adults. So far, few studies have investigated the associations between PUFA status and performance-based tests of physical function. The objective of this study was to investigate the associations between the omega-3 PUFA levels (eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA)) in red blood cell (RBC) membranes and physical performance, in a sample of community-dwelling older adults. This is a longitudinal observational study using data from the Multidomain Alzheimer's Disease Trial (MAPT), a randomized, placebo-controlled trial. Four hundred participants from MAPT placebo group with available PUFA data were included. Omega-3 PUFA levels in RBC membranes were measured at baseline, and their percentage of total RBC membrane fatty acid content was calculated. We dichotomized the standardized omega-3 PUFA levels in RBC membranes as low (lowest quartile) vs. high (three upper quartiles). Gait speed (in m/s) and short physical performance battery (SPPB) score (range from 0 to 12, higher is better) were used to assess physical performance at baseline and after 6, 12, 24, and 36 months. Participants were 75.2 (¬± 4.3) years old and 68% were female. Bivariate analyses found that the characteristic of the participants in the lowest quartile of omega-3 PUFA levels (Q1) and those in the three upper quartiles (Q2-Q4) was not different at baseline; only those in Q1 were slightly older. In an unadjusted model, the difference in gait speed after 3 years of follow-up was significant (- 0.09 ¬± 0.03 m/s; p = 0.008) between participants in Q1 and those in Q2-Q4. In a model adjusted for age, gender, educational level, cognitive function, depressive status, body mass index, physical activity, grip strength, and their time interaction, this difference remained clinically relevant (- 0.07 ¬± 0.04 m/s; p = 0.075). No difference between the two groups was found for the SPPB score development over 3 years. Older adults with subjective memory complaints and in the lower quartile of omega-3 have a faster decline on gait speed compared to people in the three upper quartiles. Other longitudinal studies are needed to explore this association and to examine mechanisms. 

Retracted: Yes

PubPeer comments:
 Retraction, January 2022, found here: https: link.springer.com article 10.1007 s11357-021-00505-z  The Editors-in-Chief have retracted this article because it contains text in the introduction and discussion sections that overlaps with a previous published article by a different author group [1]. Bertrand Fougere, Christelle Cantet, Gaelle Soriano, Sophie Guyonnet, Philipe De Souto Barreto, Matteo Cesari, Sandrine Andrieu and Bruno Vellas agree with this retraction. Bertrand Fougere agrees with this retraction on behalf of the MAPT Study Group. Sabine Gossier has not responded to correspondence from the publisher about this retraction. ,