microRNA‚Ä?95 alleviates endothelial cell inflammatory injury in coronary heart disease via blockade of the NF‚ÄêŒ∫B pathway by targeting RALB
Authors: Zhe Li
Gang Wang
Feng-Feng Lv
Zheng Lian
Li-Qiu Yan
Journal: Journal of Cellular Physiology (2020)
Discipline: MOLECULAR BIOLOGY & GENETICS
Keywords: Retraction; microRNA-495; endothelial cell; inflammatory injury; coronary heart disease
Affiliations: The First Department of Cardiovascular Medicine, Cangzhou Central Hospital, Cangzhou, China.

Abstract:  Retraction: 'microRNA-495 alleviates endothelial cell inflammatory injury in coronary heart disease via blockade of the NF-?B pathway by targeting RALB', by Feng-Feng Lv, Zheng Lian, Li-Qiu Yan, Gang Wang, Zhe Li, J Cell Physiol.: The above article, published online on 18 August 2020 in Wiley Online Library (https://onlinelibrary.wiley.com/doi/full/10.1002/jcp.29679), has been retracted by agreement between the journal's Editor in Chief, Prof. Dr. Gregg Fields, and Wiley Periodicals LLC. The retraction has been agreed following an investigation based on allegations raised by a third party. Several flaws and inconsistencies between results presented and experimental methods described were found. Thus, the editors consider the conclusions of this article to be invalid. 

Retracted: No

PubPeer comments:
 Fig 2(c).  RALB positive expression rate and endothelial cell apoptosis rate are increased in arterial tissues of normal mice (u00d7200).... (c) Cell apoptosis in mouse arterial tissues in the ... CHD groups measured by TUNEL staining; the arrows in the figure represent apoptotic cells .  Readers are invited to count the occurrences of one particular nucleus. , 
 Fig 8(a).  Upregulation of miRu2010495 or silencing of RALB results in a shortened G0 G1 phase and extended the S phase of endothelial cells. (a) cell cycle diagrams in each group detected by PI staining .  I have concerns about these bunched-up, overhanging raw-data histograms. They are as if steeples with too much belly fat are doing sit-ups. , 
 Retracted (no separate retraction notice): ------------------------------------------- The above article, published online on 18 August 2020 in Wiley Online Library , has been retracted by agreement between the journal s Editor in Chief, Prof. Dr. Gregg Fields, and Wiley Periodicals LLC. The retraction has been agreed following an investigation based on allegations raised by a third party. Several flaws and inconsistencies between results presented and experimental methods described were found. Thus, the editors consider the conclusions of this article to be invalid. , 
 #3 Evidently the editors and publishers agreed with my doubts about the authenticity of the data. Is it fair to assume that the western blots in this paper are also suspect, along with WBs in other papers that seem to sample the same gamut?  Is it fair to assume that any scatterplots are also suspect, when they purport to be the results of low cytometry but resemble toppling pineapples?  , 
 Western Blots again:  For comparison, a compilation of WBs from other papers, each with its own PP thread. Clockwise from upper left: - [Wang et al (2020)] - [Gao et al (2021)] - [Chen et al (2020)] - [He et al (2021)] .  To my mind there is (as it were) a family kinship among them all, all sampling a small corner of  morphological space . ,