LncRNA SNHG3 enhances the malignant progress of glioma through silencing KLF2 and p21
Authors: Fan Fei
Mengni Li
Zhongze He
Youyu Wang
Sen He
Yongsheng He
Gang Wu
Journal: Bioscience reports (2018)
Discipline: MOLECULAR BIOLOGY & GENETICS
Keywords: KLF2; SNHG3; glioma; p21.
Affiliations: Department of Neurosurgery, Hospital of The University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, No.32 West Second Section First Ring Road, Chengdu 610072, Sichuan, China., Department of Neurosurgery, Graduate School of Zunyi Medical University, Zunyi 563003, Guizhou, China., Department of Thoracic Surgery, Hospital of The University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, No.32 West Second Section First Ring Road, Chengdu 610072, Sichuan, China., Department of¬†Hepatobiliary surgery, Hospital of The University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, No.32 West Second Section First Ring Road, Chengdu 610072, Sichuan, China., Department of Pediatrics, Hospital of The University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, No.32 West Second Section First Ring Road, Chengdu 610072, Sichuan, China .

Abstract:  As a newly discovered long non-coding RNA, small nucleolar RNA host gene 3 (SHNG3) has been reported to be dysregulated in certain cancers. Nevertheless, the details about clinical values and biological effects of SNHG3 on glioma are still covered. In this paper, we determined the expression level of SNHG3 in glioma tissues and cells and evaluated the effect of SNHG3 expression on the prognosis of glioma patients. The functional assays were applied to define the effects of SNHG3 on the biological behaviors in glioma including cell proliferation, cell cycle, and apoptosis. It was revealed that SNHG3 was much more enriched in glioma tissues and cell lines than in normal ones. Furthermore, gain- or loss-of-function experiments indicated that the up-regulation of SNHG3 promoted cell proliferation, accelerate cell cycle progress, and repressed cell apoptosis. The mechanistic assays disclosed that SNHG3 facilitated the malignant progression of glioma through epigenetically repressing KLF2 and p21 via recruiting enhancer of zeste homolog 2 to the promoter of KLF2 and p21. Generally, it was exposed that SNHG3 might function as an oncogene in glioma and could be explored as a potential prognostic biomarker and therapeutic target for glioma. 

Retracted: No

PubPeer comments:
 Images in figure 2C appear to have some unexpected overlap. ***  *** Nicely illustrated by Forensically  , 
 Also some unexpected similarities in Figure 3E. Not identical plots, but many repeated plot locations. ***  , 
 The Western blot and figure 6C appears to have some repeating motifs in the background, somewhat suggestive of evidence of editing. Perhaps the authors could provide an original uncropped scan. *** Enhanced contrast  , 
 https: doi.org 10.1042 BSR-20180420_EOC The Editorial Office has been made aware of potential issues surrounding the scientific validity of this paper, hence has issued an expression of concern to notify readers whilst the Editorial Office investigates. , 
 Perhaps it s time for the journal to address the concerns or remove the EoC? , 
 Retracted [14 October 2021] . ------------------------ This Retraction follows an Expression of Concern relating to this article previously published by Portland Press. This article is being retracted from Bioscience Reports at the request of the Editor-in-Chief and the Editorial Board following receipt of a notification from a reader, alerting the Editorial Board a duplicated image in Figure 2C as well as concerns with the similarity of data in Figure 3E and concerns with the Western blots in Figure 6C. After notification by the Editorial Office, the authors agreed to the Retraction. Given the extent of the issues raised, the Editorial Board stand by the decision to retract the article. ,