Two Coordination Polymers Containing 4,4‚Ä?Di(1H-Benzo[D]Imidazol-1-yl)Biphenyl Ligand: Crystal Structures and Anticancer Activity on Human Multiple Myeloma Cells
Authors: Li, S.
Li, X.
Guo, W.
Rao, B.
Wang, Y.
Yang, S.
Zhang, F.
Journal: Journal of Structural Chemistry (2020)
Discipline: CHEMISTRY
Keywords: Solvothermal reactions; Coordination polymers; RPMI-8226; CCK-8 assay; Hoechst staining

Abstract: Solvothermal reactions of Co(NO3)2¬∑6H2O or Ni(NO3)2¬∑3H2O with 4,4‚Ä?di(1H-benzo[d]imidazol-1-yl)biphenyl (bimbb) and 2,6-pyridinedicarboxylic acid (H2pdc) afford two one-dimensional coordination polymers with the chemical formulas [Co(bimbb)2(pdc)](H2O)2(1) and [Ni(bimbb)2(pdc)](H2O)2(2). Complexes 1 and 2 are characterized by the elemental analysis and single crystal X-ray diffraction. The RPMI-8226 human multiple myeloma cell proliferation is determined by the CCK-8 assay after treatment with complexes 1 and 2. The morphological changes of treated RPMI-8226 are observed with the Hoechst staining method, and the apoptotic related protein levels are determined by western blot after treatment with complexes 1 and 2.

Retracted: No

PubPeer comments:
 Retracted [15 February 2021] . From the wording of the Retraction, it appears that the authors were not able to perform the experiments described in the paper, implying that these were outsourced. ---------------- The named authors hereby wholly retract this Journal of Structural Chemistry article. The authors became aware that the crystal structure data and SEM images, namely Fig. 1 and Fig 4, do not correspond to the samples of the CPs that they used in the bioactivity evaluation section in this paper. The authors do not have the facilities to repeat these characterization methods in their laboratory to verify the characteristics and bioactivity of the reported CPs and therefore they are retracting this paper to protect the accuracy and integrity of the scientific record. -------------------------- I also have concerns with the References. Were these also outsourced?  The usefulness of coordination metal complexes in cancer chemotherapy has been demonstrated by cisplatin and other platinum coordination compounds which are amongst the most successfully used anticancer drugs [5]. - [5]. H. Li, G. Gao, R. Chen, X. Ge, S. Guo, and L. Y. Hao. Int. J. Softw. Eng. Know., 2019, 29, 93. ** The Influence Ranking for Testers in Bug Tracking Systems **  As a result of an intense and continued research on coordination complexes with an antitumor activity, compounds of different metals other than Pt are entering clinical studies [6]. - [6]. S. Guo, R. Chen, H. Li, T. Zhang, and Y. Liu. Int. J. Softw. Eng. Know., 2019, 29, 139. ** Identify Severity Bug Report with Distribution Imbalance by CR-SMOTE and ELM ** , 
 Fig 4(c,d).  *[left]* Fig 3d from [Liu Li (2020)] . *[right]* Fig 2 from [Zhu, Huang Liu (2020)] .  , 
 *[left]* Fig 2 from [Shu et al (2020)] . *[right]* the present Fig 4, and Fig 3 from [Liu Li (2020)] .  See also Fig 2c from [Deng et al (2020)] and Fig 3 from [Zhang (2021)] .  The SEM diagrams for nano 1 (c) and 2 (d). AND Supplementary Figure S1 from [Liu et al (2022)] . Fig 3(c) from [Yi et al (2020)] . ,