ABCB1 C3435T Polymorphism and the Risk of Ischemic Heart Disease: A Meta-Analysis
Authors: Ming-Ming Lei
Yong Wang
Chi Miao
Yuan-Zhe Jin
Shao-Bo Zhou
Qi Wang
Li-Jie Wang
Journal: Genetic testing and molecular biomarkers (2014)
Discipline: MOLECULAR BIOLOGY & GENETICS
Keywords: ABCB1; transporter; cardiovascular disease; polymorphisms; ischemic heart disease
Affiliations: Department of Cardiology, The Fourth Affiliated Hospital of China Medical University, Shenyang, People's Republic of China.

Abstract:  ATP binding cassette transporter 1 (ABCB1) plays a critical role in the development and progression of cardiovascular disease. Emerging evidence suggests that common functional polymorphisms in the ABCB1 gene might have an impact on an individual's susceptibility to ischemic heart disease, but individually published results are inconclusive. The MEDLINE (1966-2013), the Cochrane Library Database (Issue 12, 2013), EMBASE (1980-2013), CINAHL (1982-2013), Web of Science (1945-2013), and the Chinese Biomedical Database (CBM; 1982-2013) were searched without language restrictions. Meta-analysis was performed with the use of the STATA statistical software. Odds ratios (OR) with their 95% confidence intervals (95% CIs) were calculated. Seven case-control studies with a total of 2310 myocardial infarction (MI) patients and 10,506 acute coronary syndrome (ACS) patients met the inclusion criteria. Our meta-analysis results indicated that ABCB1 C3435T polymorphism may be associated with an increased risk of MI and ACS, especially among Asian populations (T allele vs. C allele: OR=1.40, 95% CI=1.31-1.49, ph=0.058). Meta-regression analyses showed that clinical subtype and ethnicity may be the main sources of heterogeneity (T allele vs. C allele: OR=1.16, 95% CI=0.97-1.37, ph=0.036). Our findings provide empirical evidence that ABCB1 C3435T polymorphism may contribute to the risk of MI and ACS, especially among Caucasian populations. Thus, detection of ABCB1 C3435T polymorphism may be a promising biomarker for the early detection of MI and ACS. 

Retracted: No

PubPeer comments:
 This meta-analysis is quite similar with a previous meta-analysis by the authors group in 2013 (10.1089 gtmb.2013.0407). Both articles have 7 figures. Figure 2 to 7 are the same in the two papers. It is a serious problem. The authors should clarify this. , 
  Heterogeneity among studies was estimated by the Cochranu2019s Q-statistic and I^2 tests (Zintzaras and Ioannidis, 2005). - Zintzaras E, Ioannidis JP (2005) HEGESMA: genome search meta-analysis and heterogeneity testing. Bioinformatics 21:3672u20133673. Could the authors comment on the relevance of Zintzaras and Ioannidis (2005) to Cochran s Q or the I^2 test?  The clinical significance of ABCB1 includes not only its involvement in multidrug resistance in cancer but also its effects on the pharmacokinetic properties of various drugs (Zintzaras and Ioannidis, 2005). Really? My curiosity was piqued by the prevalence of this irrelevant citation, with the citing papers sharing many other features in common. https: scholar.google.com scholar?hl=en as_sdt=0%2C5 q= We+would+like+to+acknowledge+the+reviewers+for+their+helpful+comments+on+this+paper +Zintzaras+Ioannidis+limitations btnG=   , 
 https: pubpeer.com search?q=%22Yuanzhe+Jin%22+OR+%22Yuan-zhe+Jin%22 ,