RETRACTED ARTICLE: Amygdalin reduces lipopolysaccharide-induced chronic liver injury in rats by down-regulating PI3K/AKT, JAK2/STAT3 and NF-Œ∫B signalling pathways
Authors: Xiaoqin Song
Fuqin Li
Jie Zhao
Wei-Wei Wang
Yang Yang
Lifeng Li
Jia Shang
Journal: Artificial Cells Nanomedicine and Biotechnology (2019)
Discipline: BIOLOGY & BIOCHEMISTRY
Keywords: Amygdalin; inflammation; lipopolysaccharide; liver injury.
Affiliations: a Department of Nosocomial Infection Management, the First Affiliated Hospital of Zhengzhou University , Zhengzhou , PR China., b Center of Telemedicine, the First Affiliated Hospital of Zhengzhou University , Zhengzhou , PR China., c Department of Infectious Diseases, Henan Provincial People's Hospital , Zhengzhou , Henan , PR China., d Department of Pathology, The Fourth Affiliated Hospital Of Nantong University & The Sixth People's Hospital of Yancheng City , Yancheng , PR China.

Abstract:  This study was aimed to evaluate the anti-inflammatory potential of AG on lipopolysaccharide (LPS) -induced liver injury and investigate the underlying mechanism. Administration of LPSs in the rat produced rat liver injury model which was ascertained at histological and molecular levels. Those models were treated with a range of doses of LPSs (0.5, 1.0 and 1.5 mg/kg body weight), followed by measurement physical parameter and function of the liver. Within the max treatment doses, no toxicity was shown but protective effects of AG were evidenced by regulation of physical parameters and functions of the liver. Interestingly, nuclear factor kappa B (NF-Œ∫B) levels and inflammatory factors were down-regulated by AG. Furthermore, the histopathological analysis demonstrated that AG promoted recovery from dysfunction of liver tissue in the rats, which was further confirmed by observing expression changes of inflammation-associated proteins. Particularly, alteration in the PI3K/AKT and JAK2/STAT3 signalling pathway protein expression were regulated by AG in a dose-dependent manner, indicating the mechanism underlying the relief effect of AG in liver injury. Our study demonstrated the potential of AG in the management of complications related to liver injury. 

Retracted: Yes

PubPeer comments:
 Retracted [11 January 2021] . -------------------------------------- We, the Editors and Publisher of the journal Artificial Cells, Nanomedicine, and Biotechnology, have retracted the following article:u202f Yang Yang, Jie Zhao, Xiaoqin Song, Lifeng Li, Fuqin Li, Jia Shang Wei-Wei Wang (2019) Amygdalin reduces lipopolysaccharide-induced chronic liver injury in rats by down-regulating PI3K AKT, JAK2 STAT3 and NF-u03baB signalling pathways. Artificial Cells, Nanomedicine, and Biotechnology, 47:1, 2688u20132697, DOI: https: doi.org 10.1080 21691401.2019.1634084 It has come to our attention that the full authorship and affiliations for this manuscript were changed entirely since submission. We have contacted the authors for an explanation, and they responded to all of our queries on the matter, but they were unable to provide a satisfactory explanation. The authors apologise for this situation. As determining authorship is core to the integrity of published work, we are therefore retracting the article. The corresponding author listed in this publication has been informed. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions.u202f The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as u2018Retractedu2019.u202f ,