The effects of magnesium and vitamin E co-supplementation on parameters of glucose homeostasis and lipid profiles in patients with gestational diabetes
Authors: Elaheh Amirani
Mehri Jamilian
Maryam Chamani
Zatollah Asemi
Maryam Maktabi
Journal: Lipids in Health and Disease (2018)
Discipline: BIOLOGY & BIOCHEMISTRY
Keywords: Gestational diabetes; Insulin; Lipid; Supplementation.
Affiliations: Endocrinology and Metabolism Research Center, Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran., Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran., Department of Gynecology and Obstetrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran. .

Abstract:  Background: Magnesium and vitamin E are known to exert multiple beneficial effects, such as anti-glycemic and anti-lipidemic properties. The aim of this study was to determine the effects of magnesium and vitamin E co-supplementation on metabolic status of women with gestational diabetes (GDM). Methods: This randomized, double-blinded, placebo-controlled trial was conducted among 60 subjects diagnosed with GDM, aged 18-40 years. Subjects were randomly allocated into two groups to receive 250 mg/day magnesium oxide plus 400 IU/day vitamin E supplements or placebo (n = 30 each group) for 6 weeks. Participants' blood samples were taken to determine their metabolic profiles. Results: Subjects who received magnesium plus vitamin E supplements had significantly lower fasting plasma glucose (Œ≤ - 5.20 mg/dL; 95% CI, - 7.88, - 2.52; P = 0.002), serum insulin levels (Œ≤ - 2.93 ŒºIU/mL; 95% CI, - 5.68, - 0.18; P = 0.02) and homeostasis model of assessment-insulin resistance (Œ≤ - 0.78; 95% CI, - 1.42, - 0.14; P = 0.01), and higher quantitative insulin sensitivity check index (Œ≤ 0.01; 95% CI, 0.005, 0.02; P = 0.002) compared with placebo. In addition, magnesium plus vitamin E supplementation resulted in a significant reduction in serum triglycerides (Œ≤ - 50.31 mg/dL; 95% CI, - 67.58, - 33.04; P &lt; 0.001), VLDL- (Œ≤ - 10.06 mg/dL; 95% CI, - 13.51, - 6.60; P &lt; 0.001), total- (Œ≤ - 26.10 mg/dL; 95% CI, - 41.88, - 10.33; P = 0.004), LDL- (Œ≤ - 15.20 mg/dL; 95% CI, - 29.50, - 0.91; P = 0.03) and total-/HDL-cholesterol ratio (Œ≤ - 0.46; 95% CI, - 0.72, - 0.19; P &lt; 0.001) compared with placebo. Magnesium and vitamin E co-supplementation did not affect HDL-cholesterol levels. Conclusions: Overall, magnesium and vitamin E co-supplementation for 6 weeks in women with GDM significantly improved glycemic control and lipid profiles, except for HDL-cholesterol levels. Clinical trial registration number: http://www.irct.ir : IRCT20170513033941N24. 

Retracted: No

PubPeer comments:
 There are many concerns about the integrity of 172 publications by this research group, including this one. Some of the concerns are published 1. Anaesthesia 2020;75:1683u201392, see Supplementary data. This paper is A148 2. Account Res 2020;28:149-61. 3. J Clin Epidemiol 2021;131:22-29. Journals and publishers were notified of these concerns in July 2019. 18 publications have an expression of concern, and 6 have been retracted. To our knowledge there has been no public response about any of the concerns. We think these publications are unreliable ,