Repression of lncRNA-SVUGP2 mediated by EZH2 contributes to the development of non-small cell lung cancer via brisking Wnt/Œ≤-catenin signal
Authors: Jinghao Liu
Xin Li
Xingyu Liu
Sen Wei
Journal: Artificial Cells Nanomedicine and Biotechnology (2019)
Discipline: BIOLOGY & BIOCHEMISTRY
Keywords: Wnt/Œ≤-catenin signal; EZH2; Non-small cell lung cancer; lncRNA-SVUGP2.
Affiliations: a Department of Lung Cancer Surgery, General Hospital of Tianjin Medical University , Tianjin 300052 , China.

Abstract:  To grab the possible impact of lncRNA-SVUGP2 in the biology and process of non-small cell lung cancer (NSCLC). Sixty paired NSCLC tumour and the adjacent non-tumour lung tissues were collected for detection of lncRNA-SVUGP2. lncRNA-SVUGP2 expression in NSCLC cells (SK-MES-1, A549, SPC-A1, and NCI-H1975) was also detected. lncRNA-SVUGP2 was overexpressed and depressed in A549 and H1975 cells, and the effects of lncRNA-SVUGP2 dysregulation on cell biological performances including viability, colony formation, apoptosis, migration and invasion were grabbed. Furthermore, the regulatory association of lncRNA-SVUGP2 vs. EZH2 in H1975 cells, as well as the association between lncRNA-SVUGP2 and Wnt/Œ≤-catenin pathway, was explored. lncRNA-SVUGP2 was depressed in NSCLC tissues and cells. Overexpression of lncRNA-SVUGP2 depressed proliferation, induced apoptosis, and suppressed migration and invasion of A549 and H1975 cells. In addition, lncRNA-SVUGP2 was repressed by EZH2 and was inversely correlated with EZH2 levels in H1975 cells. Repression of lncRNA-SVUGP2 potentially participated in the oncogenic function of EZH2. Besides, overexpression of lncRNA-SVUGP2 depressed the briskness of Wnt/Œ≤-catenin signal in H1975 cells. Our data reveal that lncRNA-SVUGP2 is under-expressed in NSCLC cells and the reduced expression of lncRNA-SVUGP2 may enhance the development and process of NSCLC by interacting with EZH2 and activating Wnt/Œ≤-catenin pathway. 

Retracted: Yes

PubPeer comments:
 Fig 1.  Stylised WBs and flaw cytometry; colony plates that appear to have been drawn with a felt-pen; smudgy smoky Invasion images full of repeated motifs... these are hallmarks of the [ tadpole papermill ] . , 
 Retracted [26 April 2022] . ------------------ We, the Editors and Publisher of the journal *Artificial Cells, Nanomedicine, and Biotechnology*, have retracted the following article: Sen Wei, Jinghao Liu, Xin Li Xingyu Liu (2019) Repression of lncRNA-SVUGP2 mediated by EZH2 contributes to the development of non-small cell lung cancer via brisking Wnt u03b2-catenin signal. Artificial Cells, Nanomedicine, and Biotechnology, 47:1, 3400u20133409, DOI: 10.1080 21691401.2019.1648279) Since publication, the authors repeated some of their experiments and found that under the same conditions they could not repeat the results reported in this paper. As this error directly impacts the reported results and conclusions the authors alerted the issue to the Editor and Publisher and all have agreed to retract the article to ensure correction of the scholarly record. We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as u2018Retractedu2019. , 
 #2  We have been informed in our decision-making by ... the COPE guidelines on retractions This must be the little-known clause in the COPE guidelines that says  Accept the authors excuse for requesting a retraction, however implausible it might be . , 
 #3 I suspect your concerns are well-placed. If one were to look within this paper for repetitive elements, one would likely be even more convinced. ,