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+<?xml version="1.0" encoding="UTF-8"?>
+<!DOCTYPE collection SYSTEM "BioC.dtd">
+<collection>
+  <source>PMC</source>
+  <date>20230813</date>
+  <key>pmc.key</key>
+  <document>
+    <id>5063996</id>
+    <infon key="license">CC BY</infon>
+    <infon key="tt_curatable">no</infon>
+    <infon key="tt_version">2</infon>
+    <infon key="tt_round">2</infon>
+    <passage>
+      <infon key="alt-title">Mechanism of Arabinoxylanase</infon>
+      <infon key="article-id_doi">10.1074/jbc.M116.743948</infon>
+      <infon key="article-id_pmc">5063996</infon>
+      <infon key="article-id_pmid">27531750</infon>
+      <infon key="article-id_publisher-id">M116.743948</infon>
+      <infon key="fpage">22149</infon>
+      <infon key="issue">42</infon>
+      <infon key="kwd">cellulosome crystallography enzyme kinetics enzyme mechanism glycoside hydrolase</infon>
+      <infon key="license">Author's Choice—Final version free via Creative Commons CC-BY license.</infon>
+      <infon key="lpage">22159</infon>
+      <infon key="name_0">surname:Labourel;given-names:Aurore</infon>
+      <infon key="name_1">surname:Crouch;given-names:Lucy I.</infon>
+      <infon key="name_10">surname:Najmudin;given-names:Shabir</infon>
+      <infon key="name_11">surname:Baslé;given-names:Arnaud</infon>
+      <infon key="name_12">surname:Cuskin;given-names:Fiona</infon>
+      <infon key="name_2">surname:Brás;given-names:Joana L. A.</infon>
+      <infon key="name_3">surname:Jackson;given-names:Adam</infon>
+      <infon key="name_4">surname:Rogowski;given-names:Artur</infon>
+      <infon key="name_5">surname:Gray;given-names:Joseph</infon>
+      <infon key="name_6">surname:Yadav;given-names:Madhav P.</infon>
+      <infon key="name_7">surname:Henrissat;given-names:Bernard</infon>
+      <infon key="name_8">surname:Fontes;given-names:Carlos M. G. A.</infon>
+      <infon key="name_9">surname:Gilbert;given-names:Harry J.</infon>
+      <infon key="section_type">TITLE</infon>
+      <infon key="type">front</infon>
+      <infon key="volume">291</infon>
+      <infon key="year">2016</infon>
+      <offset>0</offset>
+      <text>The Mechanism by Which Arabinoxylanases Can Recognize Highly Decorated Xylans*</text>
+      <annotation id="1">
+        <infon key="score">0.99930334</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:23Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="23" length="16"/>
+        <text>Arabinoxylanases</text>
+      </annotation>
+      <annotation id="925">
+        <infon key="type">protein_state</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:47:12Z</infon>
+        <location offset="54" length="16"/>
+        <text>Highly Decorated</text>
+      </annotation>
+      <annotation id="2">
+        <infon key="score">0.9991499</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:31Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="71" length="6"/>
+        <text>Xylans</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">ABSTRACT</infon>
+      <infon key="type">abstract</infon>
+      <offset>79</offset>
+      <text>The enzymatic degradation of plant cell walls is an important biological process of increasing environmental and industrial significance. Xylan, a major component of the plant cell wall, consists of a backbone of β-1,4-xylose (Xylp) units that are often decorated with arabinofuranose (Araf) side chains. A large penta-modular enzyme, CtXyl5A, was shown previously to specifically target arabinoxylans. The mechanism of substrate recognition displayed by the enzyme, however, remains unclear. Here we report the crystal structure of the arabinoxylanase and the enzyme in complex with ligands. The data showed that four of the protein modules adopt a rigid structure, which stabilizes the catalytic domain. The C-terminal non-catalytic carbohydrate binding module could not be observed in the crystal structure, suggesting positional flexibility. The structure of the enzyme in complex with Xylp-β-1,4-Xylp-β-1,4-Xylp-[α-1,3-Araf]-β-1,4-Xylp showed that the Araf decoration linked O3 to the xylose in the active site is located in the pocket (−2* subsite) that abuts onto the catalytic center. The −2* subsite can also bind to Xylp and Arap, explaining why the enzyme can utilize xylose and arabinose as specificity determinants. Alanine substitution of Glu68, Tyr92, or Asn139, which interact with arabinose and xylose side chains at the −2* subsite, abrogates catalytic activity. Distal to the active site, the xylan backbone makes limited apolar contacts with the enzyme, and the hydroxyls are solvent-exposed. This explains why CtXyl5A is capable of hydrolyzing xylans that are extensively decorated and that are recalcitrant to classic endo-xylanase attack.</text>
+      <annotation id="3">
+        <infon key="score">0.9984566</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:41Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="108" length="5"/>
+        <text>plant</text>
+      </annotation>
+      <annotation id="4">
+        <infon key="score">0.99672145</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:48Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="217" length="5"/>
+        <text>Xylan</text>
+      </annotation>
+      <annotation id="5">
+        <infon key="score">0.99865866</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:41Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="249" length="5"/>
+        <text>plant</text>
+      </annotation>
+      <annotation id="6">
+        <infon key="score">0.9991608</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:55Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="292" length="12"/>
+        <text>β-1,4-xylose</text>
+      </annotation>
+      <annotation id="7">
+        <infon key="score">0.99928457</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:01Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="306" length="4"/>
+        <text>Xylp</text>
+      </annotation>
+      <annotation id="8">
+        <infon key="score">0.99911076</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:08Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="348" length="15"/>
+        <text>arabinofuranose</text>
+      </annotation>
+      <annotation id="9">
+        <infon key="score">0.99916506</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:15Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="365" length="4"/>
+        <text>Araf</text>
+      </annotation>
+      <annotation id="10">
+        <infon key="score">0.9825443</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:23Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="392" length="20"/>
+        <text>penta-modular enzyme</text>
+      </annotation>
+      <annotation id="11">
+        <infon key="score">0.99902785</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:29Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="414" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="12">
+        <infon key="score">0.9981812</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="467" length="13"/>
+        <text>arabinoxylans</text>
+      </annotation>
+      <annotation id="13">
+        <infon key="score">0.9987552</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:48Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="591" length="17"/>
+        <text>crystal structure</text>
+      </annotation>
+      <annotation id="14">
+        <infon key="score">0.9991007</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:56Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="616" length="15"/>
+        <text>arabinoxylanase</text>
+      </annotation>
+      <annotation id="15">
+        <infon key="score">0.9980863</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:03Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="647" length="15"/>
+        <text>in complex with</text>
+      </annotation>
+      <annotation id="16">
+        <infon key="score">0.50939804</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:08Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="663" length="7"/>
+        <text>ligands</text>
+      </annotation>
+      <annotation id="17">
+        <infon key="score">0.9991667</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:19Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="767" length="16"/>
+        <text>catalytic domain</text>
+      </annotation>
+      <annotation id="18">
+        <infon key="score">0.99892145</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:25Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="800" length="41"/>
+        <text>non-catalytic carbohydrate binding module</text>
+      </annotation>
+      <annotation id="19">
+        <infon key="score">0.99877536</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:49Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="871" length="17"/>
+        <text>crystal structure</text>
+      </annotation>
+      <annotation id="20">
+        <infon key="score">0.99855906</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:12Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="929" length="9"/>
+        <text>structure</text>
+      </annotation>
+      <annotation id="21">
+        <infon key="score">0.9979739</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:04Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="953" length="15"/>
+        <text>in complex with</text>
+      </annotation>
+      <annotation id="22">
+        <infon key="score">0.998847</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:27:35Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="969" length="50"/>
+        <text>Xylp-β-1,4-Xylp-β-1,4-Xylp-[α-1,3-Araf]-β-1,4-Xylp</text>
+      </annotation>
+      <annotation id="23">
+        <infon key="score">0.9983198</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:15Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="1036" length="4"/>
+        <text>Araf</text>
+      </annotation>
+      <annotation id="24">
+        <infon key="score">0.9865536</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:32Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="1069" length="6"/>
+        <text>xylose</text>
+      </annotation>
+      <annotation id="25">
+        <infon key="score">0.9988514</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:27:57Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="1083" length="11"/>
+        <text>active site</text>
+      </annotation>
+      <annotation id="26">
+        <infon key="score">0.9991247</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:55:26Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="1113" length="6"/>
+        <text>pocket</text>
+      </annotation>
+      <annotation id="27">
+        <infon key="score">0.9987526</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:55:19Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="1121" length="11"/>
+        <text>−2* subsite</text>
+      </annotation>
+      <annotation id="28">
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+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:28:03Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="1154" length="16"/>
+        <text>catalytic center</text>
+      </annotation>
+      <annotation id="29">
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+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:55:30Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="1176" length="11"/>
+        <text>−2* subsite</text>
+      </annotation>
+      <annotation id="30">
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+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:01Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="1205" length="4"/>
+        <text>Xylp</text>
+      </annotation>
+      <annotation id="31">
+        <infon key="score">0.9991721</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:38:24Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="1214" length="4"/>
+        <text>Arap</text>
+      </annotation>
+      <annotation id="32">
+        <infon key="score">0.9986651</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:33Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="1258" length="6"/>
+        <text>xylose</text>
+      </annotation>
+      <annotation id="33">
+        <infon key="score">0.9984883</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:41Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="1269" length="9"/>
+        <text>arabinose</text>
+      </annotation>
+      <annotation id="34">
+        <infon key="score">0.99220085</infon>
+        <infon key="type">experimental_method</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:49Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="1308" length="20"/>
+        <text>Alanine substitution</text>
+      </annotation>
+      <annotation id="35">
+        <infon key="score">0.99950814</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:53Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="1332" length="5"/>
+        <text>Glu68</text>
+      </annotation>
+      <annotation id="36">
+        <infon key="score">0.99953973</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:59Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="1339" length="5"/>
+        <text>Tyr92</text>
+      </annotation>
+      <annotation id="37">
+        <infon key="score">0.99952006</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:27:04Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="1349" length="6"/>
+        <text>Asn139</text>
+      </annotation>
+      <annotation id="38">
+        <infon key="score">0.9983119</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="1377" length="9"/>
+        <text>arabinose</text>
+      </annotation>
+      <annotation id="39">
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+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:33Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="1391" length="6"/>
+        <text>xylose</text>
+      </annotation>
+      <annotation id="40">
+        <infon key="score">0.99881476</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:55:33Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="1417" length="11"/>
+        <text>−2* subsite</text>
+      </annotation>
+      <annotation id="41">
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+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:27:57Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="1474" length="11"/>
+        <text>active site</text>
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+      <annotation id="42">
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+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:49Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="1491" length="5"/>
+        <text>xylan</text>
+      </annotation>
+      <annotation id="43">
+        <infon key="score">0.99551225</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:48:32Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="1575" length="15"/>
+        <text>solvent-exposed</text>
+      </annotation>
+      <annotation id="44">
+        <infon key="score">0.9989027</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:30Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="1610" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="45">
+        <infon key="score">0.9959501</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:32Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="1644" length="6"/>
+        <text>xylans</text>
+      </annotation>
+      <annotation id="46">
+        <infon key="score">0.9521629</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:27:42Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="1719" length="13"/>
+        <text>endo-xylanase</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">INTRO</infon>
+      <infon key="type">title_1</infon>
+      <offset>1757</offset>
+      <text>Introduction</text>
+    </passage>
+    <passage>
+      <infon key="section_type">INTRO</infon>
+      <infon key="type">paragraph</infon>
+      <offset>1770</offset>
+      <text>The plant cell wall is an important biological substrate. This complex composite structure is depolymerized by microorganisms that occupy important highly competitive ecological niches, whereas the process makes an important contribution to the carbon cycle. Lignocellulosic degradation is also of continued interest to environmentally sensitive industries such as the biofuels and biorefinery sectors, where the use of sustainable or renewable substrates is of increasing importance. Given that the plant cell wall is the most abundant source of renewable organic carbon on the planet, this macromolecular substrate has substantial industrial potential.</text>
+      <annotation id="47">
+        <infon key="score">0.9988167</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:41Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="1774" length="5"/>
+        <text>plant</text>
+      </annotation>
+      <annotation id="48">
+        <infon key="score">0.9986657</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:43:54Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="1881" length="14"/>
+        <text>microorganisms</text>
+      </annotation>
+      <annotation id="49">
+        <infon key="score">0.9988594</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:42Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="2270" length="5"/>
+        <text>plant</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">INTRO</infon>
+      <infon key="type">paragraph</infon>
+      <offset>2425</offset>
+      <text>An example of the chemical complexity of the plant cell wall is provided by xylan, which is the major hemicellulosic component. This polysaccharide comprises a backbone of β-1,4-d-xylose residues in their pyranose configuration (Xylp) that are decorated at O2 with 4-O-methyl-d-glucuronic acid (GlcA) and at O2 and/or O3 with α-l-arabinofuranose (Araf) residues, whereas the polysaccharide can also be extensively acetylated. In addition, the Araf side chain decorations can also be esterified to ferulic acid that, in some species, provide a chemical link between hemicellulose and lignin. The precise structure of xylans varies between plant species, in particular in different tissues and during cellular differentiation. In specialized plant tissues, such as the outer layer of cereal grains, xylans are extremely complex, and side chains may comprise a range of other sugars including l- and d-galactose and β- and α-Xylp units. Indeed, in these cereal brans, xylans have very few backbone Xylp units that are undecorated, and the side chains can contain up to six sugars.</text>
+      <annotation id="50">
+        <infon key="score">0.9986474</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:42Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="2470" length="5"/>
+        <text>plant</text>
+      </annotation>
+      <annotation id="51">
+        <infon key="score">0.97633845</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:49Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="2501" length="5"/>
+        <text>xylan</text>
+      </annotation>
+      <annotation id="52">
+        <infon key="score">0.90193385</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:28:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="2558" length="14"/>
+        <text>polysaccharide</text>
+      </annotation>
+      <annotation id="53">
+        <infon key="score">0.99882466</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:28:55Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="2597" length="14"/>
+        <text>β-1,4-d-xylose</text>
+      </annotation>
+      <annotation id="1005">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:41:15Z</infon>
+        <location offset="2630" length="8"/>
+        <text>pyranose</text>
+      </annotation>
+      <annotation id="54">
+        <infon key="score">0.99762434</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:02Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="2654" length="4"/>
+        <text>Xylp</text>
+      </annotation>
+      <annotation id="55">
+        <infon key="score">0.99699223</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:29:48Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="2690" length="28"/>
+        <text>4-O-methyl-d-glucuronic acid</text>
+      </annotation>
+      <annotation id="56">
+        <infon key="score">0.99859554</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:29:53Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="2720" length="4"/>
+        <text>GlcA</text>
+      </annotation>
+      <annotation id="57">
+        <infon key="score">0.9988452</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:30:05Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="2751" length="19"/>
+        <text>α-l-arabinofuranose</text>
+      </annotation>
+      <annotation id="58">
+        <infon key="score">0.99826837</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:15Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="2772" length="4"/>
+        <text>Araf</text>
+      </annotation>
+      <annotation id="59">
+        <infon key="score">0.92519265</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:28:43Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="2800" length="14"/>
+        <text>polysaccharide</text>
+      </annotation>
+      <annotation id="60">
+        <infon key="score">0.99387217</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:15Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="2868" length="4"/>
+        <text>Araf</text>
+      </annotation>
+      <annotation id="61">
+        <infon key="score">0.99838805</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:38:30Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="2922" length="12"/>
+        <text>ferulic acid</text>
+      </annotation>
+      <annotation id="62">
+        <infon key="score">0.72233874</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:29:25Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="2990" length="13"/>
+        <text>hemicellulose</text>
+      </annotation>
+      <annotation id="899">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:29:37Z</infon>
+        <location offset="3008" length="6"/>
+        <text>lignin</text>
+      </annotation>
+      <annotation id="63">
+        <infon key="score">0.48770082</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:32Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="3041" length="6"/>
+        <text>xylans</text>
+      </annotation>
+      <annotation id="64">
+        <infon key="score">0.99851996</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:42Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="3063" length="5"/>
+        <text>plant</text>
+      </annotation>
+      <annotation id="65">
+        <infon key="score">0.99830014</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:42Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="3165" length="5"/>
+        <text>plant</text>
+      </annotation>
+      <annotation id="66">
+        <infon key="score">0.9969138</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:43:46Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="3207" length="6"/>
+        <text>cereal</text>
+      </annotation>
+      <annotation id="67">
+        <infon key="score">0.70049024</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:32Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="3222" length="6"/>
+        <text>xylans</text>
+      </annotation>
+      <annotation id="68">
+        <infon key="score">0.99178773</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:38:37Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="3298" length="6"/>
+        <text>sugars</text>
+      </annotation>
+      <annotation id="69">
+        <infon key="score">0.998679</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:29:15Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="3315" length="18"/>
+        <text>l- and d-galactose</text>
+      </annotation>
+      <annotation id="70">
+        <infon key="score">0.9987858</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:29:11Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="3338" length="13"/>
+        <text>β- and α-Xylp</text>
+      </annotation>
+      <annotation id="71">
+        <infon key="score">0.9947548</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:43:46Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="3376" length="6"/>
+        <text>cereal</text>
+      </annotation>
+      <annotation id="72">
+        <infon key="score">0.57896805</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:32Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="3390" length="6"/>
+        <text>xylans</text>
+      </annotation>
+      <annotation id="73">
+        <infon key="score">0.99786454</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:02Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="3420" length="4"/>
+        <text>Xylp</text>
+      </annotation>
+      <annotation id="74">
+        <infon key="score">0.93305</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:38:41Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="3495" length="6"/>
+        <text>sugars</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">INTRO</infon>
+      <infon key="type">paragraph</infon>
+      <offset>3517</offset>
+      <text>Reflecting the chemical and physical complexity of the plant cell wall, microorganisms that utilize these composite structures express a large number of polysaccharide-degrading enzymes, primarily glycoside hydrolases, but also polysaccharide lyases, carbohydrate esterases, and lytic polysaccharide monooxygenases. These carbohydrate active enzymes are grouped into sequence-based families in the CAZy database. With respect to xylan degradation, the backbone of simple xylans is hydrolyzed by endo-acting xylanases, the majority of which are located in glycoside hydrolase (GH)5 families GH10 and GH11, although they are also present in GH8. The extensive decoration of the xylan backbone generally restricts the capacity of these enzymes to attack the polysaccharide prior to removal of the side chains by a range of α-glucuronidases, α-arabinofuranosidases, and esterases. Two xylanases, however, utilize the side chains as essential specificity determinants and thus target decorated forms of the hemicellulose. The GH30 glucuronoxylanases require the Xylp bound at the −2 to contain a GlcA side chain (the scissile bond targeted by glycoside hydrolases is between subsites −1 and +1, and subsites that extend toward the non-reducing and reducing ends of the substrate are assigned increasing negative and positive numbers, respectively). The GH5 arabinoxylanase (CtXyl5A) derived from Clostridium thermocellum displays an absolute requirement for xylans that contain Araf side chains. In this enzyme, the key specificity determinant is the Araf appended to O3 of the Xylp bound in the active site (−1 subsite). The reaction products generated from arabinoxylans, however, suggest that Araf can be accommodated at subsites distal to the active site.</text>
+      <annotation id="75">
+        <infon key="score">0.99864966</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:42Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="3572" length="5"/>
+        <text>plant</text>
+      </annotation>
+      <annotation id="76">
+        <infon key="score">0.99864155</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:43:53Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="3589" length="14"/>
+        <text>microorganisms</text>
+      </annotation>
+      <annotation id="77">
+        <infon key="score">0.65709233</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:30:23Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="3670" length="32"/>
+        <text>polysaccharide-degrading enzymes</text>
+      </annotation>
+      <annotation id="78">
+        <infon key="score">0.9984101</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:30:27Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="3714" length="20"/>
+        <text>glycoside hydrolases</text>
+      </annotation>
+      <annotation id="79">
+        <infon key="score">0.9986268</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:30:38Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="3745" length="21"/>
+        <text>polysaccharide lyases</text>
+      </annotation>
+      <annotation id="80">
+        <infon key="score">0.99855816</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:30:43Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="3768" length="22"/>
+        <text>carbohydrate esterases</text>
+      </annotation>
+      <annotation id="81">
+        <infon key="score">0.99858</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:30:54Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="3796" length="35"/>
+        <text>lytic polysaccharide monooxygenases</text>
+      </annotation>
+      <annotation id="82">
+        <infon key="score">0.99558616</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:31:00Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="3839" length="27"/>
+        <text>carbohydrate active enzymes</text>
+      </annotation>
+      <annotation id="83">
+        <infon key="score">0.99593437</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:49Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="3946" length="5"/>
+        <text>xylan</text>
+      </annotation>
+      <annotation id="84">
+        <infon key="score">0.99739957</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:32Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="3988" length="6"/>
+        <text>xylans</text>
+      </annotation>
+      <annotation id="85">
+        <infon key="score">0.99709374</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:31:07Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="4012" length="21"/>
+        <text>endo-acting xylanases</text>
+      </annotation>
+      <annotation id="86">
+        <infon key="score">0.9923669</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:31:19Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="4072" length="19"/>
+        <text>glycoside hydrolase</text>
+      </annotation>
+      <annotation id="87">
+        <infon key="score">0.99262285</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:31:27Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="4093" length="2"/>
+        <text>GH</text>
+      </annotation>
+      <annotation id="88">
+        <infon key="score">0.9738185</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:31:44Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="4096" length="1"/>
+        <text>5</text>
+      </annotation>
+      <annotation id="89">
+        <infon key="score">0.9936046</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:31:49Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="4107" length="4"/>
+        <text>GH10</text>
+      </annotation>
+      <annotation id="90">
+        <infon key="score">0.99484766</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:31:54Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="4116" length="4"/>
+        <text>GH11</text>
+      </annotation>
+      <annotation id="91">
+        <infon key="score">0.9940958</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:31:59Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="4156" length="3"/>
+        <text>GH8</text>
+      </annotation>
+      <annotation id="92">
+        <infon key="score">0.9956683</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:49Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="4193" length="5"/>
+        <text>xylan</text>
+      </annotation>
+      <annotation id="93">
+        <infon key="score">0.99571615</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:28:43Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="4272" length="14"/>
+        <text>polysaccharide</text>
+      </annotation>
+      <annotation id="94">
+        <infon key="score">0.99883527</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:32:36Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="4337" length="16"/>
+        <text>α-glucuronidases</text>
+      </annotation>
+      <annotation id="95">
+        <infon key="score">0.9988317</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:32:43Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="4355" length="22"/>
+        <text>α-arabinofuranosidases</text>
+      </annotation>
+      <annotation id="96">
+        <infon key="score">0.9990785</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:32:49Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="4383" length="9"/>
+        <text>esterases</text>
+      </annotation>
+      <annotation id="97">
+        <infon key="score">0.99923325</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:33:02Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="4398" length="9"/>
+        <text>xylanases</text>
+      </annotation>
+      <annotation id="98">
+        <infon key="score">0.9843167</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:29:26Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="4519" length="13"/>
+        <text>hemicellulose</text>
+      </annotation>
+      <annotation id="99">
+        <infon key="score">0.99851674</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:33:15Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="4538" length="4"/>
+        <text>GH30</text>
+      </annotation>
+      <annotation id="100">
+        <infon key="score">0.99904984</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:33:19Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="4543" length="18"/>
+        <text>glucuronoxylanases</text>
+      </annotation>
+      <annotation id="101">
+        <infon key="score">0.99920505</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:02Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="4574" length="4"/>
+        <text>Xylp</text>
+      </annotation>
+      <annotation id="102">
+        <infon key="score">0.9013893</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:33:40Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="4579" length="8"/>
+        <text>bound at</text>
+      </annotation>
+      <annotation id="103">
+        <infon key="score">0.99698335</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:55:43Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="4592" length="2"/>
+        <text>−2</text>
+      </annotation>
+      <annotation id="104">
+        <infon key="score">0.94409853</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:29:53Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="4608" length="4"/>
+        <text>GlcA</text>
+      </annotation>
+      <annotation id="105">
+        <infon key="score">0.9941329</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:30:28Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="4655" length="20"/>
+        <text>glycoside hydrolases</text>
+      </annotation>
+      <annotation id="1015">
+        <infon key="type">site</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:56:02Z</infon>
+        <location offset="4687" length="18"/>
+        <text>subsites −1 and +1</text>
+      </annotation>
+      <annotation id="106">
+        <infon key="score">0.9901659</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:56:05Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="4711" length="8"/>
+        <text>subsites</text>
+      </annotation>
+      <annotation id="107">
+        <infon key="score">0.9971566</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:40:58Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="4865" length="3"/>
+        <text>GH5</text>
+      </annotation>
+      <annotation id="108">
+        <infon key="score">0.9978956</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:57Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="4869" length="15"/>
+        <text>arabinoxylanase</text>
+      </annotation>
+      <annotation id="109">
+        <infon key="score">0.99816823</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:30Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="4886" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="110">
+        <infon key="score">0.9986105</infon>
+        <infon key="type">species</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:33:35Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="4908" length="24"/>
+        <text>Clostridium thermocellum</text>
+      </annotation>
+      <annotation id="111">
+        <infon key="score">0.99725866</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:32Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="4970" length="6"/>
+        <text>xylans</text>
+      </annotation>
+      <annotation id="112">
+        <infon key="score">0.99785656</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:15Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="4990" length="4"/>
+        <text>Araf</text>
+      </annotation>
+      <annotation id="113">
+        <infon key="score">0.99804723</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:15Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="5063" length="4"/>
+        <text>Araf</text>
+      </annotation>
+      <annotation id="114">
+        <infon key="score">0.999025</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:02Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="5090" length="4"/>
+        <text>Xylp</text>
+      </annotation>
+      <annotation id="115">
+        <infon key="score">0.9891261</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:33:45Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="5095" length="8"/>
+        <text>bound in</text>
+      </annotation>
+      <annotation id="116">
+        <infon key="score">0.99886334</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:27:57Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="5108" length="11"/>
+        <text>active site</text>
+      </annotation>
+      <annotation id="117">
+        <infon key="score">0.9914019</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:56:14Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="5121" length="10"/>
+        <text>−1 subsite</text>
+      </annotation>
+      <annotation id="118">
+        <infon key="score">0.99909043</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="5171" length="13"/>
+        <text>arabinoxylans</text>
+      </annotation>
+      <annotation id="119">
+        <infon key="score">0.99802303</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:15Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="5208" length="4"/>
+        <text>Araf</text>
+      </annotation>
+      <annotation id="120">
+        <infon key="score">0.99847084</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:56:18Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="5236" length="8"/>
+        <text>subsites</text>
+      </annotation>
+      <annotation id="121">
+        <infon key="score">0.99856865</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:27:57Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="5259" length="11"/>
+        <text>active site</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">INTRO</infon>
+      <infon key="type">paragraph</infon>
+      <offset>5280</offset>
+      <text>CtXyl5A is a multimodular enzyme containing, in addition to the GH5 catalytic module (CtGH5); three non-catalytic carbohydrate binding modules (CBMs) belonging to families 6 (CtCBM6), 13 (CtCBM13), and 62 (CtCBM62); fibronectin type 3 (Fn3) domain; and a C-terminal dockerin domain Fig. 1. Previous studies of Fn3 domains have indicated that they might function as ligand-binding modules, as a compact form of peptide linkers or spacers between other domains, as cellulose-disrupting modules, or as proteins that help large enzyme complexes remain soluble. The dockerin domain recruits the enzyme into the cellulosome, a multienzyme plant cell wall degrading complex presented on the surface of C. thermocellum. CtCBM6 stabilizes CtGH5, and CtCBM62 binds to d-galactopyranose and l-arabinopyranose. The function of the CtCBM13 and Fn3 modules remains unclear. Similarly, the mechanism of substrate recognition and its impact on specificity are key unresolved issues. This report exploits the crystal structure of mature CtXyl5A lacking its C-terminal dockerin domain (CtXyl5A-Doc), and the enzyme in complex with ligands, to explore the mechanism of substrate specificity. The data show that the plasticity in substrate recognition enables the enzyme to hydrolyze highly complex xylans that are not accessible to classical GH10 and GH11 endo-xylanases.</text>
+      <annotation id="122">
+        <infon key="score">0.99918216</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:30Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="5280" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="123">
+        <infon key="score">0.67755586</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:40:58Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="5344" length="3"/>
+        <text>GH5</text>
+      </annotation>
+      <annotation id="124">
+        <infon key="score">0.9980315</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:35:54Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="5348" length="16"/>
+        <text>catalytic module</text>
+      </annotation>
+      <annotation id="125">
+        <infon key="score">0.860335</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:01Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="5366" length="5"/>
+        <text>CtGH5</text>
+      </annotation>
+      <annotation id="126">
+        <infon key="score">0.9982284</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:07Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="5380" length="42"/>
+        <text>non-catalytic carbohydrate binding modules</text>
+      </annotation>
+      <annotation id="127">
+        <infon key="score">0.9514713</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:11Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="5424" length="4"/>
+        <text>CBMs</text>
+      </annotation>
+      <annotation id="128">
+        <infon key="score">0.3509473</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:28Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="5452" length="1"/>
+        <text>6</text>
+      </annotation>
+      <annotation id="129">
+        <infon key="score">0.6156626</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:40Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="5455" length="6"/>
+        <text>CtCBM6</text>
+      </annotation>
+      <annotation id="130">
+        <infon key="score">0.29874778</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:53Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="5464" length="2"/>
+        <text>13</text>
+      </annotation>
+      <annotation id="131">
+        <infon key="score">0.874645</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:03Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="5468" length="7"/>
+        <text>CtCBM13</text>
+      </annotation>
+      <annotation id="132">
+        <infon key="score">0.6269602</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:18Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="5482" length="2"/>
+        <text>62</text>
+      </annotation>
+      <annotation id="133">
+        <infon key="score">0.8562604</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:35Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="5486" length="7"/>
+        <text>CtCBM62</text>
+      </annotation>
+      <annotation id="134">
+        <infon key="score">0.9989775</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:53Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="5496" length="18"/>
+        <text>fibronectin type 3</text>
+      </annotation>
+      <annotation id="135">
+        <infon key="score">0.9988217</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:38:03Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="5516" length="3"/>
+        <text>Fn3</text>
+      </annotation>
+      <annotation id="136">
+        <infon key="score">0.99874604</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:38:09Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="5546" length="8"/>
+        <text>dockerin</text>
+      </annotation>
+      <annotation id="137">
+        <infon key="score">0.999186</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:38:04Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="5590" length="3"/>
+        <text>Fn3</text>
+      </annotation>
+      <annotation id="138">
+        <infon key="score">0.9520046</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:51:22Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="5645" length="22"/>
+        <text>ligand-binding modules</text>
+      </annotation>
+      <annotation id="139">
+        <infon key="score">0.9833201</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:38:20Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="5743" length="28"/>
+        <text>cellulose-disrupting modules</text>
+      </annotation>
+      <annotation id="140">
+        <infon key="score">0.9987042</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:38:10Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="5841" length="8"/>
+        <text>dockerin</text>
+      </annotation>
+      <annotation id="141">
+        <infon key="score">0.99853694</infon>
+        <infon key="type">complex_assembly</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:38:32Z</infon>
+        <infon key="identifier">GO:</infon>
+        <location offset="5886" length="11"/>
+        <text>cellulosome</text>
+      </annotation>
+      <annotation id="142">
+        <infon key="score">0.98729646</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:42Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="5913" length="5"/>
+        <text>plant</text>
+      </annotation>
+      <annotation id="143">
+        <infon key="score">0.99846244</infon>
+        <infon key="type">species</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:38:26Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="5975" length="15"/>
+        <text>C. thermocellum</text>
+      </annotation>
+      <annotation id="144">
+        <infon key="score">0.57434464</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:40Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="5992" length="6"/>
+        <text>CtCBM6</text>
+      </annotation>
+      <annotation id="145">
+        <infon key="score">0.6251633</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:01Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="6010" length="5"/>
+        <text>CtGH5</text>
+      </annotation>
+      <annotation id="146">
+        <infon key="score">0.59856856</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:36Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="6021" length="7"/>
+        <text>CtCBM62</text>
+      </annotation>
+      <annotation id="147">
+        <infon key="score">0.99911016</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:38:43Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="6038" length="17"/>
+        <text>d-galactopyranose</text>
+      </annotation>
+      <annotation id="148">
+        <infon key="score">0.99909335</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:38:47Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="6060" length="17"/>
+        <text>l-arabinopyranose</text>
+      </annotation>
+      <annotation id="149">
+        <infon key="score">0.98460996</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:04Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="6099" length="7"/>
+        <text>CtCBM13</text>
+      </annotation>
+      <annotation id="905">
+        <infon key="type">structure_element</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:38:04Z</infon>
+        <location offset="6111" length="3"/>
+        <text>Fn3</text>
+      </annotation>
+      <annotation id="150">
+        <infon key="score">0.9985752</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:49Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="6272" length="17"/>
+        <text>crystal structure</text>
+      </annotation>
+      <annotation id="151">
+        <infon key="score">0.99908304</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:39:04Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="6293" length="6"/>
+        <text>mature</text>
+      </annotation>
+      <annotation id="152">
+        <infon key="score">0.9991793</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:30Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="6300" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="153">
+        <infon key="score">0.99882346</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:39:06Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="6308" length="7"/>
+        <text>lacking</text>
+      </annotation>
+      <annotation id="907">
+        <infon key="type">structure_element</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:38:10Z</infon>
+        <location offset="6331" length="8"/>
+        <text>dockerin</text>
+      </annotation>
+      <annotation id="154">
+        <infon key="score">0.7470989</infon>
+        <infon key="type">mutant</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:39:59Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="6348" length="11"/>
+        <text>CtXyl5A-Doc</text>
+      </annotation>
+      <annotation id="893">
+        <infon key="type">protein_state</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:04Z</infon>
+        <location offset="6377" length="15"/>
+        <text>in complex with</text>
+      </annotation>
+      <annotation id="910">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:40:19Z</infon>
+        <location offset="6393" length="7"/>
+        <text>ligands</text>
+      </annotation>
+      <annotation id="155">
+        <infon key="score">0.9989073</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:32Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="6559" length="6"/>
+        <text>xylans</text>
+      </annotation>
+      <annotation id="156">
+        <infon key="score">0.99873036</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:31:50Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="6603" length="4"/>
+        <text>GH10</text>
+      </annotation>
+      <annotation id="157">
+        <infon key="score">0.99821556</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:31:54Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="6612" length="4"/>
+        <text>GH11</text>
+      </annotation>
+      <annotation id="158">
+        <infon key="score">0.9986395</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:35:35Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="6617" length="14"/>
+        <text>endo-xylanases</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="file">zbc0441653440001.jpg</infon>
+      <infon key="id">F1</infon>
+      <infon key="section_type">FIG</infon>
+      <infon key="type">fig_caption</infon>
+      <offset>6633</offset>
+      <text>Molecular architecture of GH5_34 enzymes. Modules prefaced by GH, CBM, or CE are modules in the indicated glycoside hydrolase, carbohydrate binding module, or carbohydrate esterase families, respectively. Laminin_3_G domain belongs to the concanavalin A lectin superfamily, and FN3 denotes a fibronectin type 3 domain. Segments labeled D are dockerin domains.</text>
+      <annotation id="958">
+        <infon key="type">protein_type</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:36:54Z</infon>
+        <location offset="6659" length="6"/>
+        <text>GH5_34</text>
+      </annotation>
+      <annotation id="159">
+        <infon key="score">0.7534902</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:41:23Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="6695" length="2"/>
+        <text>GH</text>
+      </annotation>
+      <annotation id="160">
+        <infon key="score">0.9863507</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:51:27Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="6699" length="3"/>
+        <text>CBM</text>
+      </annotation>
+      <annotation id="161">
+        <infon key="score">0.99045384</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:51:31Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="6707" length="2"/>
+        <text>CE</text>
+      </annotation>
+      <annotation id="162">
+        <infon key="score">0.99766254</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:31:20Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="6739" length="19"/>
+        <text>glycoside hydrolase</text>
+      </annotation>
+      <annotation id="163">
+        <infon key="score">0.7450091</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:42:37Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="6760" length="27"/>
+        <text>carbohydrate binding module</text>
+      </annotation>
+      <annotation id="164">
+        <infon key="score">0.9983574</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:42:23Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="6792" length="21"/>
+        <text>carbohydrate esterase</text>
+      </annotation>
+      <annotation id="911">
+        <infon key="type">structure_element</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:41:42Z</infon>
+        <location offset="6838" length="11"/>
+        <text>Laminin_3_G</text>
+      </annotation>
+      <annotation id="165">
+        <infon key="score">0.99794406</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:41:46Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="6872" length="33"/>
+        <text>concanavalin A lectin superfamily</text>
+      </annotation>
+      <annotation id="166">
+        <infon key="score">0.998723</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:38:04Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="6911" length="3"/>
+        <text>FN3</text>
+      </annotation>
+      <annotation id="167">
+        <infon key="score">0.9979355</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:51:37Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="6925" length="25"/>
+        <text>fibronectin type 3 domain</text>
+      </annotation>
+      <annotation id="908">
+        <infon key="type">structure_element</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:38:10Z</infon>
+        <location offset="6975" length="8"/>
+        <text>dockerin</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">RESULTS</infon>
+      <infon key="type">title_1</infon>
+      <offset>6993</offset>
+      <text>Results</text>
+    </passage>
+    <passage>
+      <infon key="section_type">RESULTS</infon>
+      <infon key="type">title_4</infon>
+      <offset>7001</offset>
+      <text>Substrate Specificity of CtXyl5A</text>
+      <annotation id="168">
+        <infon key="score">0.99469876</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:30Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="7026" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">RESULTS</infon>
+      <infon key="type">paragraph</infon>
+      <offset>7034</offset>
+      <text>Previous studies showed that CtXyl5A is an arabinoxylan-specific xylanase that generates xylooligosaccharides with an arabinose linked O3 to the reducing end xylose. The enzyme is active against both wheat and rye arabinoxylans (abbreviated as WAX and RAX, respectively). It was proposed that arabinose decorations make productive interactions with a pocket (−2*) that is abutted onto the active site or −1 subsite. Arabinose side chains of the other backbone xylose units in the oligosaccharides generated by CtXyl5A were essentially random. These data suggest that O3, and possibly O2, on the xylose residues at subsites distal to the active site and −2* pocket are solvent-exposed, implying that the enzyme can access highly decorated xylans. To test this hypothesis, the activity of CtXyl5A against xylans from cereal brans was assessed. CtXyl5a was incubated with a range of xylans for 16 h at 60 °C, and the limit products were visualized by TLC. These xylans are highly decorated not only with Araf and GlcA units but also with l-Gal, d-Gal, and d-Xyl. Indeed, very few xylose units in the backbone of bran xylans lack side chains. The data presented in Table 1 showed that CtXyl5A was active against corn bran xylan (CX). In contrast typical endo-xylanases from GH10 and GH11 were unable to attack CX, reflecting the lack of undecorated xylose units in the backbone (the active site of these enzymes can only bind to non-substituted xylose residues). The limit products generated by CtXyl5A from CX consisted of an extensive range of oligosaccharides. These data support the view that in subsites out with the active site the O2 and O3 groups of the bound xylose units are solvent-exposed and will thus tolerate decoration.</text>
+      <annotation id="169">
+        <infon key="score">0.999027</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:31Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="7063" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="170">
+        <infon key="score">0.9967934</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:34:39Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="7077" length="30"/>
+        <text>arabinoxylan-specific xylanase</text>
+      </annotation>
+      <annotation id="171">
+        <infon key="score">0.9990753</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:45:39Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="7123" length="20"/>
+        <text>xylooligosaccharides</text>
+      </annotation>
+      <annotation id="172">
+        <infon key="score">0.99847776</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="7152" length="9"/>
+        <text>arabinose</text>
+      </annotation>
+      <annotation id="173">
+        <infon key="score">0.99852186</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:33Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="7192" length="6"/>
+        <text>xylose</text>
+      </annotation>
+      <annotation id="174">
+        <infon key="score">0.8807422</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:44:28Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="7234" length="5"/>
+        <text>wheat</text>
+      </annotation>
+      <annotation id="175">
+        <infon key="score">0.99000096</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:44:41Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="7244" length="3"/>
+        <text>rye</text>
+      </annotation>
+      <annotation id="176">
+        <infon key="score">0.99898416</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="7248" length="13"/>
+        <text>arabinoxylans</text>
+      </annotation>
+      <annotation id="177">
+        <infon key="score">0.99872786</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:45:23Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="7278" length="3"/>
+        <text>WAX</text>
+      </annotation>
+      <annotation id="178">
+        <infon key="score">0.9978104</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:45:27Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="7286" length="3"/>
+        <text>RAX</text>
+      </annotation>
+      <annotation id="179">
+        <infon key="score">0.9987662</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="7327" length="9"/>
+        <text>arabinose</text>
+      </annotation>
+      <annotation id="180">
+        <infon key="score">0.99883765</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:56:24Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="7385" length="6"/>
+        <text>pocket</text>
+      </annotation>
+      <annotation id="1016">
+        <infon key="type">site</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:56:40Z</infon>
+        <location offset="7393" length="3"/>
+        <text>−2*</text>
+      </annotation>
+      <annotation id="181">
+        <infon key="score">0.9989691</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:27:57Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="7423" length="11"/>
+        <text>active site</text>
+      </annotation>
+      <annotation id="182">
+        <infon key="score">0.99868107</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:56:44Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="7438" length="10"/>
+        <text>−1 subsite</text>
+      </annotation>
+      <annotation id="183">
+        <infon key="score">0.99863005</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="7450" length="9"/>
+        <text>Arabinose</text>
+      </annotation>
+      <annotation id="184">
+        <infon key="score">0.99874973</infon>
+        <infon key="type">chemical</infon>
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+&lt;table frame="hsides" rules="groups"&gt;&lt;thead valign="bottom"&gt;&lt;tr&gt;&lt;th align="center" rowspan="2" colspan="1"&gt;Enzyme&lt;/th&gt;&lt;th align="center" rowspan="2" colspan="1"&gt;Variant&lt;/th&gt;&lt;th align="center" rowspan="1" colspan="3"&gt;&lt;italic&gt;k&lt;/italic&gt;&lt;sub&gt;cat&lt;/sub&gt;/&lt;italic&gt;K&lt;sub&gt;m&lt;/sub&gt;&lt;/italic&gt;&lt;hr/&gt;&lt;/th&gt;&lt;/tr&gt;&lt;tr&gt;&lt;th align="center" rowspan="1" colspan="1"&gt;WAX&lt;/th&gt;&lt;th align="center" rowspan="1" colspan="1"&gt;RAX&lt;/th&gt;&lt;th align="center" rowspan="1" colspan="1"&gt;CX&lt;/th&gt;&lt;/tr&gt;&lt;/thead&gt;&lt;tbody valign="top"&gt;&lt;tr&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;td align="center" rowspan="1" colspan="3"&gt;&lt;italic&gt;min&lt;/italic&gt;&lt;sup&gt;−&lt;italic&gt;1&lt;/italic&gt;&lt;/sup&gt;
+&lt;italic&gt;mg&lt;/italic&gt;&lt;sup&gt;−&lt;italic&gt;1&lt;/italic&gt;&lt;/sup&gt;
+&lt;italic&gt;ml&lt;/italic&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;italic&gt;Ct&lt;/italic&gt;Xyl5A&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;italic&gt;Ct&lt;/italic&gt;GH5-CBM6-CBM13-Fn3-CBM62&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;800&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;ND&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;460&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;italic&gt;Ct&lt;/italic&gt;Xyl5A&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;italic&gt;Ct&lt;/italic&gt;GH5-CBM6-CBM13-Fn3&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;1,232&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;ND&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;659&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;italic&gt;Ct&lt;/italic&gt;Xyl5A&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;italic&gt;Ct&lt;/italic&gt;GH5-CBM6-CBM13&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;1,307&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;ND&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;620&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;italic&gt;Ct&lt;/italic&gt;Xyl5A&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;italic&gt;Ct&lt;/italic&gt;GH5-CBM6&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;488&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;ND&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;102&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;italic&gt;Ct&lt;/italic&gt;Xyl5A&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;italic&gt;Ct&lt;/italic&gt;GH5-CBM6: E68A&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;NA&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;NA&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;NA&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;italic&gt;Ct&lt;/italic&gt;Xyl5A&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;italic&gt;Ct&lt;/italic&gt;GH5-CBM6: Y92A&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;NA&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;NA&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;NA&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;italic&gt;Ct&lt;/italic&gt;Xyl5A&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;italic&gt;Ct&lt;/italic&gt;GH5-CBM6: N135A&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;260&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;ND&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;ND&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;italic&gt;Ct&lt;/italic&gt;Xyl5A&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;italic&gt;Ct&lt;/italic&gt;GH5-CBM6: N139A&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;NA&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;NA&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;NA&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;italic&gt;Ac&lt;/italic&gt;GH5&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;Wild type&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;628&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;1,641&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;289&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;italic&gt;Gp&lt;/italic&gt;GH5&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;Wild type&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;2,600&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;9,986&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;314&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;italic&gt;Vb&lt;/italic&gt;GH5&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;Wild type&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;ND&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;ND&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;ND&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;italic&gt;Vb&lt;/italic&gt;GH5&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;D45A&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;102&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;203&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;23&lt;/td&gt;&lt;/tr&gt;&lt;/tbody&gt;&lt;/table&gt;
+</infon>
+      <offset>8846</offset>
+      <text>Enzyme	Variant	kcat/Km	 	WAX	RAX	CX	 			min−1mg−1ml	 	CtXyl5A	CtGH5-CBM6-CBM13-Fn3-CBM62	800	ND	460	 	CtXyl5A	CtGH5-CBM6-CBM13-Fn3	1,232	ND	659	 	CtXyl5A	CtGH5-CBM6-CBM13	1,307	ND	620	 	CtXyl5A	CtGH5-CBM6	488	ND	102	 	CtXyl5A	CtGH5-CBM6: E68A	NA	NA	NA	 	CtXyl5A	CtGH5-CBM6: Y92A	NA	NA	NA	 	CtXyl5A	CtGH5-CBM6: N135A	260	ND	ND	 	CtXyl5A	CtGH5-CBM6: N139A	NA	NA	NA	 	AcGH5	Wild type	628	1,641	289	 	GpGH5	Wild type	2,600	9,986	314	 	VbGH5	Wild type	ND	ND	ND	 	VbGH5	D45A	102	203	23	 	</text>
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+      <infon key="type">paragraph</infon>
+      <offset>9333</offset>
+      <text>To explore whether substrate bound only at −2* and −1 in the negative subsites was hydrolyzed by CtXyl5A, the limit products of CX digested by the arabinoxylanase were subjected to size exclusion chromatography using a Bio-Gel P-2, and the smallest oligosaccharides (largest elution volume) were chosen for further study. HPAEC analysis of the smallest oligosaccharide fraction (pool 4) contained two species with retention times of 14.0 min (oligosaccharide 1) and 20.8 min (oligosaccharide 2) (Fig. 2). Positive mode electrospray mass spectrometry showed that pool 4 contained exclusively molecular ions with a m/z = 305 [M + Na]+, which corresponds to a pentose-pentose disaccharide (molecular mass = 282 Da) as a sodium ion adduct, whereas a dimer of the disaccharide with a sodium adduct (m/z = 587 [2M+Na]+) was also evident. The monosaccharide composition of pool 4 determined by TFA hydrolysis contained xylose and arabinose in a 3:1 ratio. This suggests that the two oligosaccharides consist of two disaccharides: one consisting of two xylose residues and the other consisting of an arabinose linked to a xylose. Treatment of pool 4 with the nonspecific arabinofuranosidase, CjAbf51A, resulted in the loss of oligosaccharide 2 and the production of both xylose and arabinose, indicative of a disaccharide of xylose and arabinose. Incubation of pool 4 with a β-1,3-xylosidase (XynB) converted oligosaccharide 1 into xylose, demonstrating that this molecule is the disaccharide β-1,3-xylobiose. This view is supported by the inability of a β-1,4-specific xylosidase to hydrolyze oligosaccharide 1 or oligosaccharide 2 (data not shown). The crucial importance of occupancy of the −2* pocket for catalytic competence is illustrated by the inability of the enzyme to hydrolyze linear β-1,4-xylooligosaccharides. The generation of Araf-Xylp and Xyl-β-1,3-Xyl as reaction products demonstrates that occupancy of the −2 subsite is not essential for catalytic activity, which is in contrast to all endo-acting xylanases where this subsite plays a critical role in enzyme activity. Indeed, the data demonstrate that −2* plays a more important role in productive substrate binding than the −2 subsite. Unfortunately, the inability to generate highly purified (Xyl-β-1,4)n-[β-1,3-Xyl/Ara]-Xyl oligosaccharides from arabinoxylans prevented the precise binding energies at the negative subsites to be determined.</text>
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+        <infon key="updated_at">2023-09-18T13:35:57Z</infon>
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+        <text>bound only at</text>
+      </annotation>
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+        <text>−1</text>
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+        <infon key="identifier">SO:</infon>
+        <location offset="9394" length="17"/>
+        <text>negative subsites</text>
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+        <infon key="identifier">PR:</infon>
+        <location offset="9430" length="7"/>
+        <text>CtXyl5A</text>
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+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:46:39Z</infon>
+        <location offset="9461" length="2"/>
+        <text>CX</text>
+      </annotation>
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+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:57Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="9480" length="15"/>
+        <text>arabinoxylanase</text>
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+        <infon key="updated_at">2023-09-18T10:59:02Z</infon>
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+        <text>size exclusion chromatography</text>
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+        <infon key="updated_at">2023-09-18T11:03:40Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="9582" length="16"/>
+        <text>oligosaccharides</text>
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+        <infon key="updated_at">2023-09-18T10:58:49Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="9655" length="5"/>
+        <text>HPAEC</text>
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+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:38:46Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="9686" length="15"/>
+        <text>oligosaccharide</text>
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+      <annotation id="998">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:39:31Z</infon>
+        <location offset="9776" length="15"/>
+        <text>oligosaccharide</text>
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+      <annotation id="999">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:39:32Z</infon>
+        <location offset="9809" length="15"/>
+        <text>oligosaccharide</text>
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+        <infon key="type">experimental_method</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:58:57Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="9838" length="44"/>
+        <text>Positive mode electrospray mass spectrometry</text>
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+      <annotation id="949">
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+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:16:00Z</infon>
+        <location offset="9990" length="7"/>
+        <text>pentose</text>
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+      <annotation id="950">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:16:00Z</infon>
+        <location offset="9998" length="7"/>
+        <text>pentose</text>
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+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T11:03:20Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="10006" length="12"/>
+        <text>disaccharide</text>
+      </annotation>
+      <annotation id="256">
+        <infon key="score">0.8210523</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T11:03:20Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="10092" length="12"/>
+        <text>disaccharide</text>
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+      <annotation id="257">
+        <infon key="score">0.9970212</infon>
+        <infon key="type">experimental_method</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:59:12Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="10220" length="14"/>
+        <text>TFA hydrolysis</text>
+      </annotation>
+      <annotation id="258">
+        <infon key="score">0.9957487</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:33Z</infon>
+        <infon key="identifier">CHEBI:</infon>
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+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="10256" length="9"/>
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+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T11:03:41Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="10309" length="16"/>
+        <text>oligosaccharides</text>
+      </annotation>
+      <annotation id="261">
+        <infon key="score">0.9897843</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T11:04:03Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="10341" length="13"/>
+        <text>disaccharides</text>
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+      <annotation id="262">
+        <infon key="score">0.9872656</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:33Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="10378" length="6"/>
+        <text>xylose</text>
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+      <annotation id="263">
+        <infon key="score">0.97808754</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="10425" length="9"/>
+        <text>arabinose</text>
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+      <annotation id="264">
+        <infon key="score">0.9635059</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:33Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="10447" length="6"/>
+        <text>xylose</text>
+      </annotation>
+      <annotation id="947">
+        <infon key="type">protein_type</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:15:03Z</infon>
+        <location offset="10484" length="31"/>
+        <text>nonspecific arabinofuranosidase</text>
+      </annotation>
+      <annotation id="265">
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+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:54:51Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="10517" length="8"/>
+        <text>CjAbf51A</text>
+      </annotation>
+      <annotation id="997">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:39:31Z</infon>
+        <location offset="10551" length="15"/>
+        <text>oligosaccharide</text>
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+      <annotation id="266">
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+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:33Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="10596" length="6"/>
+        <text>xylose</text>
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+      <annotation id="267">
+        <infon key="score">0.9963881</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="10607" length="9"/>
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+      <annotation id="944">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T11:03:20Z</infon>
+        <location offset="10634" length="12"/>
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+      <annotation id="268">
+        <infon key="score">0.9972711</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:33Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="10650" length="6"/>
+        <text>xylose</text>
+      </annotation>
+      <annotation id="269">
+        <infon key="score">0.9962746</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="10661" length="9"/>
+        <text>arabinose</text>
+      </annotation>
+      <annotation id="270">
+        <infon key="score">0.9963164</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:55:06Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="10700" length="16"/>
+        <text>β-1,3-xylosidase</text>
+      </annotation>
+      <annotation id="271">
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+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:55:11Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="10718" length="4"/>
+        <text>XynB</text>
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+      <annotation id="1000">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:39:32Z</infon>
+        <location offset="10734" length="15"/>
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+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:33Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="10757" length="6"/>
+        <text>xylose</text>
+      </annotation>
+      <annotation id="945">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T11:03:20Z</infon>
+        <location offset="10805" length="12"/>
+        <text>disaccharide</text>
+      </annotation>
+      <annotation id="273">
+        <infon key="score">0.9992453</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:40:06Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="10818" length="15"/>
+        <text>β-1,3-xylobiose</text>
+      </annotation>
+      <annotation id="274">
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+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:59:20Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="10880" length="25"/>
+        <text>β-1,4-specific xylosidase</text>
+      </annotation>
+      <annotation id="1001">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:39:32Z</infon>
+        <location offset="10919" length="15"/>
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+      <annotation id="1002">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:39:32Z</infon>
+        <location offset="10940" length="15"/>
+        <text>oligosaccharide</text>
+      </annotation>
+      <annotation id="275">
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+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:57:13Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="11019" length="10"/>
+        <text>−2* pocket</text>
+      </annotation>
+      <annotation id="276">
+        <infon key="score">0.9992246</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:55:39Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="11121" length="26"/>
+        <text>β-1,4-xylooligosaccharides</text>
+      </annotation>
+      <annotation id="277">
+        <infon key="score">0.999252</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:55:27Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="11167" length="9"/>
+        <text>Araf-Xylp</text>
+      </annotation>
+      <annotation id="278">
+        <infon key="score">0.9992756</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:40:11Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="11181" length="13"/>
+        <text>Xyl-β-1,3-Xyl</text>
+      </annotation>
+      <annotation id="279">
+        <infon key="score">0.9986477</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:57:16Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="11251" length="10"/>
+        <text>−2 subsite</text>
+      </annotation>
+      <annotation id="280">
+        <infon key="score">0.9981468</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:31:07Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="11331" length="21"/>
+        <text>endo-acting xylanases</text>
+      </annotation>
+      <annotation id="281">
+        <infon key="score">0.99076325</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:57:20Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="11364" length="7"/>
+        <text>subsite</text>
+      </annotation>
+      <annotation id="282">
+        <infon key="score">0.99634886</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:57:23Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="11448" length="3"/>
+        <text>−2*</text>
+      </annotation>
+      <annotation id="283">
+        <infon key="score">0.9985508</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:57:26Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="11521" length="10"/>
+        <text>−2 subsite</text>
+      </annotation>
+      <annotation id="951">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:18:33Z</infon>
+        <location offset="11590" length="32"/>
+        <text>(Xyl-β-1,4)n-[β-1,3-Xyl/Ara]-Xyl</text>
+      </annotation>
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+        <infon key="score">0.9294588</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T11:03:41Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="11623" length="16"/>
+        <text>oligosaccharides</text>
+      </annotation>
+      <annotation id="888">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:42Z</infon>
+        <location offset="11645" length="13"/>
+        <text>arabinoxylans</text>
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+    </passage>
+    <passage>
+      <infon key="file">zbc0441653440002.jpg</infon>
+      <infon key="id">F2</infon>
+      <infon key="section_type">FIG</infon>
+      <infon key="type">fig_caption</infon>
+      <offset>11762</offset>
+      <text>Identification of the disaccharide reaction products generated from CX. The smallest reaction products were purified by size exclusion chromatography and analyzed by HPAEC (A) and positive mode ESI-MS (B), respectively. The samples were treated with a nonspecific arabinofuranosidase (CjAbf51A) and a GH3 xylosidase (XynB) that targeted β-1,3-xylosidic bonds. X, xylose; A, arabinose. The m/z = 305 species denotes a pentose disaccharide as a sodium adduct [M + Na]+, whereas the m/z = 587 signal corresponds to an ESI-MS dimer of the pentose disaccharide also as a sodium adduct [2M + Na]+.</text>
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+        <infon key="identifier">CHEBI:</infon>
+        <location offset="11784" length="12"/>
+        <text>disaccharide</text>
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+        <infon key="identifier">CHEBI:</infon>
+        <location offset="11830" length="2"/>
+        <text>CX</text>
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+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:59:02Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="11882" length="29"/>
+        <text>size exclusion chromatography</text>
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+        <infon key="type">experimental_method</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:58:50Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="11928" length="5"/>
+        <text>HPAEC</text>
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+        <infon key="type">experimental_method</infon>
+        <infon key="annotator">cleaner0</infon>
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+        <infon key="identifier">MESH:</infon>
+        <location offset="11956" length="6"/>
+        <text>ESI-MS</text>
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+      <annotation id="946">
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+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:15:02Z</infon>
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+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
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+        <infon key="identifier">PR:</infon>
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+      <annotation id="948">
+        <infon key="type">protein_type</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:15:31Z</infon>
+        <location offset="12063" length="14"/>
+        <text>GH3 xylosidase</text>
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+      <annotation id="291">
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+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:55:12Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="12079" length="4"/>
+        <text>XynB</text>
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+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:33Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="12125" length="6"/>
+        <text>xylose</text>
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+      <annotation id="293">
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+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="12136" length="9"/>
+        <text>arabinose</text>
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+      <annotation id="294">
+        <infon key="score">0.9981957</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:16:00Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="12179" length="7"/>
+        <text>pentose</text>
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+        <infon key="score">0.76520646</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T11:03:20Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="12187" length="12"/>
+        <text>disaccharide</text>
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+      <annotation id="296">
+        <infon key="score">0.58194405</infon>
+        <infon key="type">experimental_method</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:14:37Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="12277" length="6"/>
+        <text>ESI-MS</text>
+      </annotation>
+      <annotation id="297">
+        <infon key="score">0.9983165</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:15:59Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="12297" length="7"/>
+        <text>pentose</text>
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+      <annotation id="298">
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+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T11:03:20Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="12305" length="12"/>
+        <text>disaccharide</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">RESULTS</infon>
+      <infon key="type">title_4</infon>
+      <offset>12357</offset>
+      <text>Crystal Structure of the Catalytic Module of CtXyl5A in Complex with Ligands</text>
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+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:49Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="12357" length="17"/>
+        <text>Crystal Structure</text>
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+        <infon key="score">0.998405</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:35:55Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="12382" length="16"/>
+        <text>Catalytic Module</text>
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+      <annotation id="301">
+        <infon key="score">0.95691925</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:31Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="12402" length="7"/>
+        <text>CtXyl5A</text>
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+      <annotation id="302">
+        <infon key="score">0.99861926</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:04Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="12410" length="15"/>
+        <text>in Complex with</text>
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+      <annotation id="303">
+        <infon key="score">0.46196067</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:40:17Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="12426" length="7"/>
+        <text>Ligands</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">RESULTS</infon>
+      <infon key="type">paragraph</infon>
+      <offset>12434</offset>
+      <text>To understand the structural basis for the biochemical properties of CtXyl5A, the crystal structure of the enzyme with ligands that occupy the substrate binding cleft and the critical −2* subsite were sought. The data presented in Fig. 3A show the structure of the CtXyl5A derivative CtGH5-CtCBM6 in complex with arabinose bound in the −2* pocket. Interestingly, the bound arabinose was in the pyranose conformation rather than in its furanose form found in arabinoxylans. O1 was facing toward the active site −1 subsite, indicative of the bound arabinose being in the right orientation to be linked to the xylan backbone via an α-1,3 linkage. As discussed on below, the axial O4 of the Arap did not interact with the −2* subsite, suggesting that the pocket might be capable of binding a xylose molecule. Indeed, soaking apo crystals with xylose showed that the pentose sugar also bound in the −2* subsite in its pyranose conformation (Fig. 3B). These crystal structures support the biochemical data presented above showing that the enzyme generated β-1,3-xylobiose from CX, which would require the disaccharide to bind at the −1 and −2* subsites. A third product complex was generated by co-crystallizing the nucleophile inactive mutant CtGH5E279S-CtCBM6 with a WAX-derived oligosaccharide (Fig. 3C). The data revealed a pentasaccharide bound to the enzyme, comprising β-1,4-xylotetraose with an Araf linked α-1,3 to the reducing end xylose. The xylotetraose was positioned in subsites −1 to −4 and the Araf in the −2* pocket. Analysis of the three structures showed that O1, O2, O3, and the endocyclic oxygen occupied identical positions in the Arap, Araf, and Xylp ligands bound in the −2* subsite and thus made identical interactions with the pocket. O1 makes a polar contact with Nδ2 of Asn139, O2 is within hydrogen bonding distance with Oδ1 of Asn139 and the backbone N of Asn135, and O3 interacts with the N of Gly136 and Oϵ2 of Glu68. Although O4 of Arap does not make a direct interaction with the enzyme, O4 and O5 of Xylp and Araf, respectively, form hydrogen bonds with Oϵ1 of Glu68. Finally Tyr92 makes apolar parallel interactions with the pyranose or furanose rings of the three sugars.</text>
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+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:31Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="12503" length="7"/>
+        <text>CtXyl5A</text>
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+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:49Z</infon>
+        <infon key="identifier">DUMMY:</infon>
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+        <text>crystal structure</text>
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+        <infon key="annotator">cleaner0</infon>
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+        <infon key="identifier">SO:</infon>
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+        <text>substrate binding cleft</text>
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+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:57:31Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="12618" length="11"/>
+        <text>−2* subsite</text>
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+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:50:13Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="12682" length="9"/>
+        <text>structure</text>
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+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:31Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="12699" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="1042">
+        <infon key="type">structure_element</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:29:50Z</infon>
+        <location offset="12718" length="12"/>
+        <text>CtGH5-CtCBM6</text>
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+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:04Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="12731" length="15"/>
+        <text>in complex with</text>
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+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="12747" length="9"/>
+        <text>arabinose</text>
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+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:33:46Z</infon>
+        <infon key="identifier">DUMMY:</infon>
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+        <text>bound in</text>
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+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:57:34Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="12770" length="10"/>
+        <text>−2* pocket</text>
+      </annotation>
+      <annotation id="314">
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+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:17:09Z</infon>
+        <infon key="identifier">DUMMY:</infon>
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+        <text>bound</text>
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+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="12807" length="9"/>
+        <text>arabinose</text>
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+      <annotation id="1004">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:41:14Z</infon>
+        <location offset="12828" length="8"/>
+        <text>pyranose</text>
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+      <annotation id="1008">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:41:26Z</infon>
+        <location offset="12869" length="8"/>
+        <text>furanose</text>
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+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="12892" length="13"/>
+        <text>arabinoxylans</text>
+      </annotation>
+      <annotation id="317">
+        <infon key="score">0.99867976</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:27:57Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="12932" length="11"/>
+        <text>active site</text>
+      </annotation>
+      <annotation id="318">
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+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:57:38Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="12944" length="10"/>
+        <text>−1 subsite</text>
+      </annotation>
+      <annotation id="319">
+        <infon key="score">0.9984829</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:17:11Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="12974" length="5"/>
+        <text>bound</text>
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+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="12980" length="9"/>
+        <text>arabinose</text>
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+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:49Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="13041" length="5"/>
+        <text>xylan</text>
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+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:40:21Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="13121" length="4"/>
+        <text>Arap</text>
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+      <annotation id="323">
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+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:57:41Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="13152" length="11"/>
+        <text>−2* subsite</text>
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+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:57:44Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="13185" length="6"/>
+        <text>pocket</text>
+      </annotation>
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+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:33Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="13222" length="6"/>
+        <text>xylose</text>
+      </annotation>
+      <annotation id="326">
+        <infon key="score">0.9983833</infon>
+        <infon key="type">experimental_method</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:21:15Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="13247" length="7"/>
+        <text>soaking</text>
+      </annotation>
+      <annotation id="327">
+        <infon key="score">0.99923503</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:21:10Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="13255" length="3"/>
+        <text>apo</text>
+      </annotation>
+      <annotation id="328">
+        <infon key="score">0.48547208</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:50:18Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="13259" length="8"/>
+        <text>crystals</text>
+      </annotation>
+      <annotation id="329">
+        <infon key="score">0.99908113</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:33Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="13273" length="6"/>
+        <text>xylose</text>
+      </annotation>
+      <annotation id="1003">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:40:56Z</infon>
+        <location offset="13296" length="7"/>
+        <text>pentose</text>
+      </annotation>
+      <annotation id="330">
+        <infon key="score">0.5487963</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:40:26Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="13304" length="5"/>
+        <text>sugar</text>
+      </annotation>
+      <annotation id="331">
+        <infon key="score">0.9981328</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:33:46Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="13315" length="8"/>
+        <text>bound in</text>
+      </annotation>
+      <annotation id="332">
+        <infon key="score">0.9983646</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:57:47Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="13328" length="11"/>
+        <text>−2* subsite</text>
+      </annotation>
+      <annotation id="1006">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:41:15Z</infon>
+        <location offset="13347" length="8"/>
+        <text>pyranose</text>
+      </annotation>
+      <annotation id="333">
+        <infon key="score">0.9988084</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:50:23Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="13386" length="18"/>
+        <text>crystal structures</text>
+      </annotation>
+      <annotation id="334">
+        <infon key="score">0.9991225</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:41:34Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="13484" length="15"/>
+        <text>β-1,3-xylobiose</text>
+      </annotation>
+      <annotation id="335">
+        <infon key="score">0.9822428</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:46:39Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="13505" length="2"/>
+        <text>CX</text>
+      </annotation>
+      <annotation id="336">
+        <infon key="score">0.9982703</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T11:03:20Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="13533" length="12"/>
+        <text>disaccharide</text>
+      </annotation>
+      <annotation id="1017">
+        <infon key="type">site</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:58:09Z</infon>
+        <location offset="13561" length="19"/>
+        <text>−1 and −2* subsites</text>
+      </annotation>
+      <annotation id="337">
+        <infon key="score">0.99872786</infon>
+        <infon key="type">experimental_method</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:05:47Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="13623" length="16"/>
+        <text>co-crystallizing</text>
+      </annotation>
+      <annotation id="338">
+        <infon key="score">0.99801016</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:36:02Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="13644" length="20"/>
+        <text>nucleophile inactive</text>
+      </annotation>
+      <annotation id="339">
+        <infon key="score">0.99902153</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:36:07Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="13665" length="6"/>
+        <text>mutant</text>
+      </annotation>
+      <annotation id="340">
+        <infon key="score">0.9535321</infon>
+        <infon key="type">mutant</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:09:45Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="13672" length="10"/>
+        <text>CtGH5E279S</text>
+      </annotation>
+      <annotation id="903">
+        <infon key="type">structure_element</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:40Z</infon>
+        <location offset="13683" length="6"/>
+        <text>CtCBM6</text>
+      </annotation>
+      <annotation id="341">
+        <infon key="score">0.98482054</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:45:23Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="13697" length="3"/>
+        <text>WAX</text>
+      </annotation>
+      <annotation id="342">
+        <infon key="score">0.9992003</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:39:32Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="13709" length="15"/>
+        <text>oligosaccharide</text>
+      </annotation>
+      <annotation id="343">
+        <infon key="score">0.9991468</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:41:37Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="13756" length="15"/>
+        <text>pentasaccharide</text>
+      </annotation>
+      <annotation id="344">
+        <infon key="score">0.9987526</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:19:16Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="13772" length="8"/>
+        <text>bound to</text>
+      </annotation>
+      <annotation id="345">
+        <infon key="score">0.99912447</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:41:41Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="13804" length="18"/>
+        <text>β-1,4-xylotetraose</text>
+      </annotation>
+      <annotation id="346">
+        <infon key="score">0.99879885</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:15Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="13831" length="4"/>
+        <text>Araf</text>
+      </annotation>
+      <annotation id="347">
+        <infon key="score">0.9987872</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:33Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="13869" length="6"/>
+        <text>xylose</text>
+      </annotation>
+      <annotation id="348">
+        <infon key="score">0.99923956</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:41:45Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="13881" length="12"/>
+        <text>xylotetraose</text>
+      </annotation>
+      <annotation id="349">
+        <infon key="score">0.9051479</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:58:13Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="13912" length="17"/>
+        <text>subsites −1 to −4</text>
+      </annotation>
+      <annotation id="350">
+        <infon key="score">0.9991596</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:15Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="13938" length="4"/>
+        <text>Araf</text>
+      </annotation>
+      <annotation id="351">
+        <infon key="score">0.9983297</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:58:16Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="13950" length="10"/>
+        <text>−2* pocket</text>
+      </annotation>
+      <annotation id="352">
+        <infon key="score">0.9958412</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:50:27Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="13984" length="10"/>
+        <text>structures</text>
+      </annotation>
+      <annotation id="353">
+        <infon key="score">0.99901795</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:40:22Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="14081" length="4"/>
+        <text>Arap</text>
+      </annotation>
+      <annotation id="354">
+        <infon key="score">0.9989477</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:15Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="14087" length="4"/>
+        <text>Araf</text>
+      </annotation>
+      <annotation id="355">
+        <infon key="score">0.9988612</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:02Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="14097" length="4"/>
+        <text>Xylp</text>
+      </annotation>
+      <annotation id="356">
+        <infon key="score">0.9988979</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:33:46Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="14110" length="8"/>
+        <text>bound in</text>
+      </annotation>
+      <annotation id="357">
+        <infon key="score">0.99790555</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:58:18Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="14123" length="11"/>
+        <text>−2* subsite</text>
+      </annotation>
+      <annotation id="358">
+        <infon key="score">0.9976653</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:58:22Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="14181" length="6"/>
+        <text>pocket</text>
+      </annotation>
+      <annotation id="359">
+        <infon key="score">0.9838765</infon>
+        <infon key="type">bond_interaction</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:20:15Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="14200" length="13"/>
+        <text>polar contact</text>
+      </annotation>
+      <annotation id="360">
+        <infon key="score">0.9994537</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:27:05Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="14226" length="6"/>
+        <text>Asn139</text>
+      </annotation>
+      <annotation id="361">
+        <infon key="score">0.99667907</infon>
+        <infon key="type">bond_interaction</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:20:11Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="14247" length="16"/>
+        <text>hydrogen bonding</text>
+      </annotation>
+      <annotation id="362">
+        <infon key="score">0.999443</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:27:05Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="14285" length="6"/>
+        <text>Asn139</text>
+      </annotation>
+      <annotation id="363">
+        <infon key="score">0.99943477</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:23:10Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="14314" length="6"/>
+        <text>Asn135</text>
+      </annotation>
+      <annotation id="364">
+        <infon key="score">0.99941826</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:06:25Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="14353" length="6"/>
+        <text>Gly136</text>
+      </annotation>
+      <annotation id="365">
+        <infon key="score">0.99930656</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:54Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="14371" length="5"/>
+        <text>Glu68</text>
+      </annotation>
+      <annotation id="366">
+        <infon key="score">0.99909437</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:40:22Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="14393" length="4"/>
+        <text>Arap</text>
+      </annotation>
+      <annotation id="367">
+        <infon key="score">0.9990483</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:02Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="14463" length="4"/>
+        <text>Xylp</text>
+      </annotation>
+      <annotation id="368">
+        <infon key="score">0.9990252</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:15Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="14472" length="4"/>
+        <text>Araf</text>
+      </annotation>
+      <annotation id="369">
+        <infon key="score">0.9971278</infon>
+        <infon key="type">bond_interaction</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:19:57Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="14497" length="14"/>
+        <text>hydrogen bonds</text>
+      </annotation>
+      <annotation id="370">
+        <infon key="score">0.99928504</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:54Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="14524" length="5"/>
+        <text>Glu68</text>
+      </annotation>
+      <annotation id="371">
+        <infon key="score">0.9993992</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:59Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="14539" length="5"/>
+        <text>Tyr92</text>
+      </annotation>
+      <annotation id="372">
+        <infon key="score">0.97813207</infon>
+        <infon key="type">bond_interaction</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:20:03Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="14558" length="21"/>
+        <text>parallel interactions</text>
+      </annotation>
+      <annotation id="1007">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:41:15Z</infon>
+        <location offset="14589" length="8"/>
+        <text>pyranose</text>
+      </annotation>
+      <annotation id="1009">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:41:27Z</infon>
+        <location offset="14601" length="8"/>
+        <text>furanose</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="file">zbc0441653440003.jpg</infon>
+      <infon key="id">F3</infon>
+      <infon key="section_type">FIG</infon>
+      <infon key="type">fig_caption</infon>
+      <offset>14671</offset>
+      <text>Representation of the residues involved in the ligands recognition at the −2* subsite. The protein backbone is represented as a cartoon in gray. Interacting residues are represented as stick in blue, and the catalytic residues and the mutated glutamate (into a serine) are in magenta. A, CtGH5-CBM6 in complex with an arabinopyranose. B, CtGH5-CBM6 in complex with a xylopyranose. C, CtGH5E279S-CBM6 in complex with a pentasaccharide (β1,4-xylotetraose with an l-Araf linked α1,3 to the reducing end xylose). The xylan backbone is shown transparently for more clarity. Densities shown in blue are RefMac maximum-likelihood σA-weighted 2Fo − Fc at 1.5 σ. The figure and all other structural figures were made with PyMOL unless otherwise stated.</text>
+      <annotation id="373">
+        <infon key="score">0.99794537</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:58:28Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="14745" length="11"/>
+        <text>−2* subsite</text>
+      </annotation>
+      <annotation id="374">
+        <infon key="score">0.99496317</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:58:36Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="14879" length="18"/>
+        <text>catalytic residues</text>
+      </annotation>
+      <annotation id="1018">
+        <infon key="type">experimental_method</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:58:46Z</infon>
+        <location offset="14906" length="7"/>
+        <text>mutated</text>
+      </annotation>
+      <annotation id="375">
+        <infon key="score">0.9964224</infon>
+        <infon key="type">residue_name</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:21:34Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="14914" length="9"/>
+        <text>glutamate</text>
+      </annotation>
+      <annotation id="376">
+        <infon key="score">0.9966878</infon>
+        <infon key="type">residue_name</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:21:37Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="14932" length="6"/>
+        <text>serine</text>
+      </annotation>
+      <annotation id="1043">
+        <infon key="type">structure_element</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:30:17Z</infon>
+        <location offset="14959" length="10"/>
+        <text>CtGH5-CBM6</text>
+      </annotation>
+      <annotation id="377">
+        <infon key="score">0.96348566</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:04Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="14970" length="15"/>
+        <text>in complex with</text>
+      </annotation>
+      <annotation id="378">
+        <infon key="score">0.9985078</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:41:51Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="14989" length="15"/>
+        <text>arabinopyranose</text>
+      </annotation>
+      <annotation id="1044">
+        <infon key="type">structure_element</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:30:42Z</infon>
+        <location offset="15009" length="10"/>
+        <text>CtGH5-CBM6</text>
+      </annotation>
+      <annotation id="379">
+        <infon key="score">0.9178238</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:04Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="15020" length="15"/>
+        <text>in complex with</text>
+      </annotation>
+      <annotation id="380">
+        <infon key="score">0.9992086</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:41:57Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="15038" length="12"/>
+        <text>xylopyranose</text>
+      </annotation>
+      <annotation id="381">
+        <infon key="score">0.99710983</infon>
+        <infon key="type">mutant</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:09:51Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="15055" length="10"/>
+        <text>CtGH5E279S</text>
+      </annotation>
+      <annotation id="939">
+        <infon key="type">structure_element</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:51:34Z</infon>
+        <location offset="15066" length="4"/>
+        <text>CBM6</text>
+      </annotation>
+      <annotation id="382">
+        <infon key="score">0.9848954</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:04Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="15071" length="15"/>
+        <text>in complex with</text>
+      </annotation>
+      <annotation id="383">
+        <infon key="score">0.99923825</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:42:01Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="15089" length="15"/>
+        <text>pentasaccharide</text>
+      </annotation>
+      <annotation id="384">
+        <infon key="score">0.99916303</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:42:04Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="15106" length="17"/>
+        <text>β1,4-xylotetraose</text>
+      </annotation>
+      <annotation id="385">
+        <infon key="score">0.999108</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:25:05Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="15132" length="6"/>
+        <text>l-Araf</text>
+      </annotation>
+      <annotation id="386">
+        <infon key="score">0.9986161</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:33Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="15171" length="6"/>
+        <text>xylose</text>
+      </annotation>
+      <annotation id="387">
+        <infon key="score">0.9975291</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:49Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="15184" length="5"/>
+        <text>xylan</text>
+      </annotation>
+      <annotation id="388">
+        <infon key="score">0.9933159</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:22:07Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="15240" length="9"/>
+        <text>Densities</text>
+      </annotation>
+      <annotation id="952">
+        <infon key="type">evidence</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:22:32Z</infon>
+        <location offset="15275" length="48"/>
+        <text>maximum-likelihood σA-weighted 2Fo − Fc at 1.5 σ</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">RESULTS</infon>
+      <infon key="type">paragraph</infon>
+      <offset>15430</offset>
+      <text>The importance of the interactions between the ligands and the side chains of the residues in the −2* pocket were evaluated by alanine substitution of these amino acids. The mutants E68A, Y92A, and N139A were all inactive (Table 1), demonstrating the importance of the interactions of these residues with the substrate and reinforcing the critical role the −2* subsite plays in the activity of the enzyme. N135A retained wild type activity because the O2 of the sugars interacts with the backbone N of Asn135 and not with the side chain. Because the hydroxyls of Xylp or Araf in the −2* pocket are not solvent-exposed, the active site of the arabinoxylanase can only bind to xylose residues that contain a single xylose or arabinose O3 decoration. This may explain why the kcat/Km for CtXyl5A against WAX was 2-fold higher than against CX (Table 1). WAX is likely to have a higher concentration of single Araf decorations compared with CX and thus contain more substrate available to the arabinoxylanase.</text>
+      <annotation id="389">
+        <infon key="score">0.99893385</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:58:53Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="15528" length="10"/>
+        <text>−2* pocket</text>
+      </annotation>
+      <annotation id="390">
+        <infon key="score">0.9966867</infon>
+        <infon key="type">experimental_method</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:23:04Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="15557" length="20"/>
+        <text>alanine substitution</text>
+      </annotation>
+      <annotation id="391">
+        <infon key="score">0.9985077</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:22:59Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="15604" length="7"/>
+        <text>mutants</text>
+      </annotation>
+      <annotation id="392">
+        <infon key="score">0.9990114</infon>
+        <infon key="type">mutant</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:49:08Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="15612" length="4"/>
+        <text>E68A</text>
+      </annotation>
+      <annotation id="393">
+        <infon key="score">0.9989949</infon>
+        <infon key="type">mutant</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:49:13Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="15618" length="4"/>
+        <text>Y92A</text>
+      </annotation>
+      <annotation id="394">
+        <infon key="score">0.99898463</infon>
+        <infon key="type">mutant</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:54:16Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="15628" length="5"/>
+        <text>N139A</text>
+      </annotation>
+      <annotation id="395">
+        <infon key="score">0.99903464</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:23:01Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="15643" length="8"/>
+        <text>inactive</text>
+      </annotation>
+      <annotation id="396">
+        <infon key="score">0.99899477</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:58:56Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="15787" length="11"/>
+        <text>−2* subsite</text>
+      </annotation>
+      <annotation id="397">
+        <infon key="score">0.9990736</infon>
+        <infon key="type">mutant</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:49:17Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="15836" length="5"/>
+        <text>N135A</text>
+      </annotation>
+      <annotation id="398">
+        <infon key="score">0.99906486</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:49:27Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="15851" length="9"/>
+        <text>wild type</text>
+      </annotation>
+      <annotation id="399">
+        <infon key="score">0.9993063</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:23:10Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="15932" length="6"/>
+        <text>Asn135</text>
+      </annotation>
+      <annotation id="400">
+        <infon key="score">0.9992543</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:02Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="15993" length="4"/>
+        <text>Xylp</text>
+      </annotation>
+      <annotation id="401">
+        <infon key="score">0.99923706</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:15Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="16001" length="4"/>
+        <text>Araf</text>
+      </annotation>
+      <annotation id="402">
+        <infon key="score">0.9989507</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:58:59Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="16013" length="10"/>
+        <text>−2* pocket</text>
+      </annotation>
+      <annotation id="926">
+        <infon key="type">protein_state</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:48:32Z</infon>
+        <location offset="16032" length="15"/>
+        <text>solvent-exposed</text>
+      </annotation>
+      <annotation id="403">
+        <infon key="score">0.99911714</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:27:57Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="16053" length="11"/>
+        <text>active site</text>
+      </annotation>
+      <annotation id="404">
+        <infon key="score">0.9991146</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:57Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="16072" length="15"/>
+        <text>arabinoxylanase</text>
+      </annotation>
+      <annotation id="405">
+        <infon key="score">0.99835086</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:33Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="16105" length="6"/>
+        <text>xylose</text>
+      </annotation>
+      <annotation id="406">
+        <infon key="score">0.9980102</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:33Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="16143" length="6"/>
+        <text>xylose</text>
+      </annotation>
+      <annotation id="407">
+        <infon key="score">0.9981377</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="16153" length="9"/>
+        <text>arabinose</text>
+      </annotation>
+      <annotation id="1012">
+        <infon key="type">evidence</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:50:52Z</infon>
+        <location offset="16203" length="4"/>
+        <text>kcat</text>
+      </annotation>
+      <annotation id="1013">
+        <infon key="type">evidence</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:51:00Z</infon>
+        <location offset="16208" length="2"/>
+        <text>Km</text>
+      </annotation>
+      <annotation id="408">
+        <infon key="score">0.9909752</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:31Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="16215" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="409">
+        <infon key="score">0.9985014</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:45:23Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="16231" length="3"/>
+        <text>WAX</text>
+      </annotation>
+      <annotation id="410">
+        <infon key="score">0.7723853</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:46:39Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="16266" length="2"/>
+        <text>CX</text>
+      </annotation>
+      <annotation id="411">
+        <infon key="score">0.99858814</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:45:23Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="16280" length="3"/>
+        <text>WAX</text>
+      </annotation>
+      <annotation id="412">
+        <infon key="score">0.99835324</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:15Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="16335" length="4"/>
+        <text>Araf</text>
+      </annotation>
+      <annotation id="413">
+        <infon key="score">0.926579</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:46:39Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="16366" length="2"/>
+        <text>CX</text>
+      </annotation>
+      <annotation id="414">
+        <infon key="score">0.99903345</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:57Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="16418" length="15"/>
+        <text>arabinoxylanase</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">RESULTS</infon>
+      <infon key="type">paragraph</infon>
+      <offset>16441</offset>
+      <text>In the active site of CtXyl5A the α-d-Xylp, which is in its relaxed 4C1 conformation, makes the following interactions with the enzyme (Fig. 4, A–C): O1 hydrogen bonds with the Nδ1 of His253 and Oϵ2 of Glu171 (catalytic acid-base) and makes a possible weak polar contact with the OH of Tyr255 and Oγ of Ser279 (mutation of the catalytic nucleophile); O2 hydrogen bonds with Nδ2 of Asn170 and OH of Tyr92. O3 (O1 of the Araf at the −2* subsite) makes a polar contact with Nδ2 of Asn139; the endocyclic oxygen hydrogens bonds with the OH of Tyr255. The Xylp in the active site makes strong parallel apolar interactions with Phe310. Substrate recognition in the active site is conserved between CtXyl5A and the closest GH5 structural homolog, the endoglucanase BaCel5A (PDB code 1qi2) as noted previously.</text>
+      <annotation id="415">
+        <infon key="score">0.99896586</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:27:57Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="16448" length="11"/>
+        <text>active site</text>
+      </annotation>
+      <annotation id="416">
+        <infon key="score">0.99930596</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:31Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="16463" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="417">
+        <infon key="score">0.9991194</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:23:44Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="16475" length="8"/>
+        <text>α-d-Xylp</text>
+      </annotation>
+      <annotation id="418">
+        <infon key="score">0.99690115</infon>
+        <infon key="type">bond_interaction</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:19:58Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="16594" length="14"/>
+        <text>hydrogen bonds</text>
+      </annotation>
+      <annotation id="419">
+        <infon key="score">0.9994248</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:23:59Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="16625" length="6"/>
+        <text>His253</text>
+      </annotation>
+      <annotation id="420">
+        <infon key="score">0.9993506</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:24:03Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="16643" length="6"/>
+        <text>Glu171</text>
+      </annotation>
+      <annotation id="421">
+        <infon key="score">0.9857984</infon>
+        <infon key="type">bond_interaction</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:20:16Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="16698" length="13"/>
+        <text>polar contact</text>
+      </annotation>
+      <annotation id="422">
+        <infon key="score">0.99934465</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:23:49Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="16727" length="6"/>
+        <text>Tyr255</text>
+      </annotation>
+      <annotation id="423">
+        <infon key="score">0.9993443</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:23:54Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="16744" length="6"/>
+        <text>Ser279</text>
+      </annotation>
+      <annotation id="424">
+        <infon key="score">0.99672544</infon>
+        <infon key="type">bond_interaction</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:19:58Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="16795" length="14"/>
+        <text>hydrogen bonds</text>
+      </annotation>
+      <annotation id="425">
+        <infon key="score">0.9993864</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:24:08Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="16822" length="6"/>
+        <text>Asn170</text>
+      </annotation>
+      <annotation id="426">
+        <infon key="score">0.9994099</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:59Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="16839" length="5"/>
+        <text>Tyr92</text>
+      </annotation>
+      <annotation id="427">
+        <infon key="score">0.999243</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:15Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="16860" length="4"/>
+        <text>Araf</text>
+      </annotation>
+      <annotation id="428">
+        <infon key="score">0.9981232</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:59:03Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="16872" length="11"/>
+        <text>−2* subsite</text>
+      </annotation>
+      <annotation id="429">
+        <infon key="score">0.9942347</infon>
+        <infon key="type">bond_interaction</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:20:16Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="16893" length="13"/>
+        <text>polar contact</text>
+      </annotation>
+      <annotation id="430">
+        <infon key="score">0.9994549</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:27:05Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="16919" length="6"/>
+        <text>Asn139</text>
+      </annotation>
+      <annotation id="431">
+        <infon key="score">0.9965925</infon>
+        <infon key="type">bond_interaction</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:24:38Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="16949" length="15"/>
+        <text>hydrogens bonds</text>
+      </annotation>
+      <annotation id="432">
+        <infon key="score">0.9993518</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:23:50Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="16980" length="6"/>
+        <text>Tyr255</text>
+      </annotation>
+      <annotation id="433">
+        <infon key="score">0.9992919</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:02Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="16992" length="4"/>
+        <text>Xylp</text>
+      </annotation>
+      <annotation id="434">
+        <infon key="score">0.99828696</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:27:57Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="17004" length="11"/>
+        <text>active site</text>
+      </annotation>
+      <annotation id="435">
+        <infon key="score">0.8674073</infon>
+        <infon key="type">bond_interaction</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:24:31Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="17029" length="28"/>
+        <text>parallel apolar interactions</text>
+      </annotation>
+      <annotation id="436">
+        <infon key="score">0.9994276</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:24:22Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="17063" length="6"/>
+        <text>Phe310</text>
+      </annotation>
+      <annotation id="437">
+        <infon key="score">0.9986855</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:27:57Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="17100" length="11"/>
+        <text>active site</text>
+      </annotation>
+      <annotation id="438">
+        <infon key="score">0.9959131</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:36:24Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="17115" length="9"/>
+        <text>conserved</text>
+      </annotation>
+      <annotation id="439">
+        <infon key="score">0.99930716</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:31Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="17133" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="440">
+        <infon key="score">0.99881834</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:40:58Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="17157" length="3"/>
+        <text>GH5</text>
+      </annotation>
+      <annotation id="441">
+        <infon key="score">0.9991805</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:34:45Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="17185" length="13"/>
+        <text>endoglucanase</text>
+      </annotation>
+      <annotation id="442">
+        <infon key="score">0.9994155</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:45:00Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="17199" length="7"/>
+        <text>BaCel5A</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="file">zbc0441653440004.jpg</infon>
+      <infon key="id">F4</infon>
+      <infon key="section_type">FIG</infon>
+      <infon key="type">fig_caption</infon>
+      <offset>17270</offset>
+      <text>Comparison of the ligand recognition at the distal negative subsites between CtGH5E279S-CBM6, the cellulase BaCel5A, and the xylanase GH10.
+A–C show CtGH5E279S-CBM6 is in complex with a pentasaccharide (β1,4-xylotetraose with an l-Araf linked α1,3 to the reducing end xylose). A, Poseview representation highlighting the hydrogen bonding and the hydrophobic interactions that occur in the negative subsites. C, density of the ligand shown in blue is RefMac maximum-likelihood σA-weighted 2Fo − Fc at 1.5 σ. D and E display BaCel5A in complex with deoxy-2-fluoro-β-d-cellotrioside (PDB code 1qi2), and F and G show CmXyn10B in complex with a xylotriose (PDB code 1uqy). The ligand are represented as sticks. B, D, and F are surface representations (CtGH5E279S-CBM6 in gray, BaCel5A in cyan, and the xylanase GH10 in light brown). C, E, and G show the protein backbone as a cartoon representation with the interacting residues represented as sticks. The black dashes represent the hydrogen bonds.</text>
+      <annotation id="443">
+        <infon key="score">0.99856913</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:59:11Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="17321" length="17"/>
+        <text>negative subsites</text>
+      </annotation>
+      <annotation id="444">
+        <infon key="score">0.9817981</infon>
+        <infon key="type">mutant</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:10:02Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="17347" length="10"/>
+        <text>CtGH5E279S</text>
+      </annotation>
+      <annotation id="445">
+        <infon key="score">0.8062502</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:51:34Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="17358" length="4"/>
+        <text>CBM6</text>
+      </annotation>
+      <annotation id="446">
+        <infon key="score">0.9989459</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:26:17Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="17368" length="9"/>
+        <text>cellulase</text>
+      </annotation>
+      <annotation id="447">
+        <infon key="score">0.999137</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:45:06Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="17378" length="7"/>
+        <text>BaCel5A</text>
+      </annotation>
+      <annotation id="448">
+        <infon key="score">0.99901605</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:34:52Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="17395" length="8"/>
+        <text>xylanase</text>
+      </annotation>
+      <annotation id="449">
+        <infon key="score">0.99872714</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:31:50Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="17404" length="4"/>
+        <text>GH10</text>
+      </annotation>
+      <annotation id="450">
+        <infon key="score">0.97036284</infon>
+        <infon key="type">mutant</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:10:05Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="17419" length="10"/>
+        <text>CtGH5E279S</text>
+      </annotation>
+      <annotation id="451">
+        <infon key="score">0.79618585</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:51:34Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="17430" length="4"/>
+        <text>CBM6</text>
+      </annotation>
+      <annotation id="452">
+        <infon key="score">0.9977508</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:04Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="17438" length="15"/>
+        <text>in complex with</text>
+      </annotation>
+      <annotation id="453">
+        <infon key="score">0.9992555</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:42:12Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="17456" length="15"/>
+        <text>pentasaccharide</text>
+      </annotation>
+      <annotation id="454">
+        <infon key="score">0.99919766</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:42:14Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="17473" length="17"/>
+        <text>β1,4-xylotetraose</text>
+      </annotation>
+      <annotation id="455">
+        <infon key="score">0.99904007</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:25:05Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="17499" length="6"/>
+        <text>l-Araf</text>
+      </annotation>
+      <annotation id="456">
+        <infon key="score">0.9987269</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:34Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="17538" length="6"/>
+        <text>xylose</text>
+      </annotation>
+      <annotation id="457">
+        <infon key="score">0.9961971</infon>
+        <infon key="type">bond_interaction</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:20:12Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="17591" length="16"/>
+        <text>hydrogen bonding</text>
+      </annotation>
+      <annotation id="458">
+        <infon key="score">0.99668086</infon>
+        <infon key="type">bond_interaction</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:25:53Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="17616" length="24"/>
+        <text>hydrophobic interactions</text>
+      </annotation>
+      <annotation id="459">
+        <infon key="score">0.9985068</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:59:14Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="17659" length="17"/>
+        <text>negative subsites</text>
+      </annotation>
+      <annotation id="460">
+        <infon key="score">0.9700168</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:25:48Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="17681" length="7"/>
+        <text>density</text>
+      </annotation>
+      <annotation id="953">
+        <infon key="type">evidence</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:25:42Z</infon>
+        <location offset="17727" length="48"/>
+        <text>maximum-likelihood σA-weighted 2Fo − Fc at 1.5 σ</text>
+      </annotation>
+      <annotation id="461">
+        <infon key="score">0.999212</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:45:09Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="17793" length="7"/>
+        <text>BaCel5A</text>
+      </annotation>
+      <annotation id="462">
+        <infon key="score">0.99365395</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:04Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="17801" length="15"/>
+        <text>in complex with</text>
+      </annotation>
+      <annotation id="463">
+        <infon key="score">0.9992079</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:42:17Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="17817" length="32"/>
+        <text>deoxy-2-fluoro-β-d-cellotrioside</text>
+      </annotation>
+      <annotation id="464">
+        <infon key="score">0.9983261</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:45:13Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="17884" length="8"/>
+        <text>CmXyn10B</text>
+      </annotation>
+      <annotation id="894">
+        <infon key="type">protein_state</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:04Z</infon>
+        <location offset="17893" length="15"/>
+        <text>in complex with</text>
+      </annotation>
+      <annotation id="465">
+        <infon key="score">0.9992083</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:42:26Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="17911" length="10"/>
+        <text>xylotriose</text>
+      </annotation>
+      <annotation id="466">
+        <infon key="score">0.9557879</infon>
+        <infon key="type">mutant</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:10:11Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="18018" length="10"/>
+        <text>CtGH5E279S</text>
+      </annotation>
+      <annotation id="467">
+        <infon key="score">0.9193694</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:51:34Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="18029" length="4"/>
+        <text>CBM6</text>
+      </annotation>
+      <annotation id="468">
+        <infon key="score">0.99914455</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:45:17Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="18043" length="7"/>
+        <text>BaCel5A</text>
+      </annotation>
+      <annotation id="469">
+        <infon key="score">0.9989845</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:34:57Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="18068" length="8"/>
+        <text>xylanase</text>
+      </annotation>
+      <annotation id="470">
+        <infon key="score">0.9984413</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:31:50Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="18077" length="4"/>
+        <text>GH10</text>
+      </annotation>
+      <annotation id="471">
+        <infon key="score">0.9951364</infon>
+        <infon key="type">bond_interaction</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:19:58Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="18249" length="14"/>
+        <text>hydrogen bonds</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">RESULTS</infon>
+      <infon key="type">paragraph</infon>
+      <offset>18283</offset>
+      <text>The capacity of CtXyl5A to act on the highly decorated xylan CX indicates that O3 and possibly O2 of the backbone Xylp units are solvent-exposed. This is consistent with the interaction of the xylotetraose backbone with the enzyme distal to the active site. A surface representation of the enzyme (Fig. 4B) shows that O3 and O2 of xylose units at subsites −2 to −4 are solvent-exposed and are thus available for decoration. Indeed, these pyranose sugars make very weak apolar interactions with the arabinoxylanase. At −2, Xylp makes planar apolar interactions with the Araf bound to the −2* subsite (Fig. 4C). Xylp at subsites −2 and −3, respectively, make weak hydrophobic contact with Val318, the −3 Xylp makes planar apolar interactions with Ala137, whereas the xylose at −4 forms parallel apolar contacts with Trp69. Comparison of the distal negative subsites of CtXyl5A with BaCel5A and a typical GH10 xylanase (CmXyn10B, PDB code 1uqy) highlights the paucity of interactions between the arabinoxylanase and its substrate out with the active site (Fig. 4). Thus, the cellulase contains three negative subsites and the sugars bound in the −2 and −3 subsites make a total of 9 polar interactions with the enzyme (Fig. 4, D and E). The GH10 xylanase also contains a −2 subsite that, similar to the cellulase, makes numerous interactions with the substrate (Fig. 4, F and G).</text>
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+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:31Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="18299" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="473">
+        <infon key="score">0.99818134</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:49Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="18338" length="5"/>
+        <text>xylan</text>
+      </annotation>
+      <annotation id="474">
+        <infon key="score">0.7490116</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:46:39Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="18344" length="2"/>
+        <text>CX</text>
+      </annotation>
+      <annotation id="475">
+        <infon key="score">0.9990195</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:02Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="18397" length="4"/>
+        <text>Xylp</text>
+      </annotation>
+      <annotation id="476">
+        <infon key="score">0.9982736</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:48:32Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="18412" length="15"/>
+        <text>solvent-exposed</text>
+      </annotation>
+      <annotation id="477">
+        <infon key="score">0.99916756</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:42:30Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="18476" length="12"/>
+        <text>xylotetraose</text>
+      </annotation>
+      <annotation id="478">
+        <infon key="score">0.9988993</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:27:57Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="18528" length="11"/>
+        <text>active site</text>
+      </annotation>
+      <annotation id="479">
+        <infon key="score">0.998987</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:34Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="18614" length="6"/>
+        <text>xylose</text>
+      </annotation>
+      <annotation id="1019">
+        <infon key="type">site</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:59:33Z</infon>
+        <location offset="18630" length="17"/>
+        <text>subsites −2 to −4</text>
+      </annotation>
+      <annotation id="480">
+        <infon key="score">0.99836254</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:48:32Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="18652" length="15"/>
+        <text>solvent-exposed</text>
+      </annotation>
+      <annotation id="481">
+        <infon key="score">0.9971443</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:41:15Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="18721" length="8"/>
+        <text>pyranose</text>
+      </annotation>
+      <annotation id="482">
+        <infon key="score">0.846215</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:42:39Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="18730" length="6"/>
+        <text>sugars</text>
+      </annotation>
+      <annotation id="1031">
+        <infon key="type">bond_interaction</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:07:27Z</infon>
+        <location offset="18752" length="19"/>
+        <text>apolar interactions</text>
+      </annotation>
+      <annotation id="483">
+        <infon key="score">0.9933171</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:57Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="18781" length="15"/>
+        <text>arabinoxylanase</text>
+      </annotation>
+      <annotation id="484">
+        <infon key="score">0.98697215</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:59:38Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="18801" length="2"/>
+        <text>−2</text>
+      </annotation>
+      <annotation id="485">
+        <infon key="score">0.9984598</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:02Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="18805" length="4"/>
+        <text>Xylp</text>
+      </annotation>
+      <annotation id="1030">
+        <infon key="type">bond_interaction</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:07:11Z</infon>
+        <location offset="18816" length="26"/>
+        <text>planar apolar interactions</text>
+      </annotation>
+      <annotation id="486">
+        <infon key="score">0.99914765</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:15Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="18852" length="4"/>
+        <text>Araf</text>
+      </annotation>
+      <annotation id="487">
+        <infon key="score">0.9965229</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:19:16Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="18857" length="8"/>
+        <text>bound to</text>
+      </annotation>
+      <annotation id="488">
+        <infon key="score">0.99492747</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:59:41Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="18870" length="11"/>
+        <text>−2* subsite</text>
+      </annotation>
+      <annotation id="489">
+        <infon key="score">0.9988463</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:02Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="18893" length="4"/>
+        <text>Xylp</text>
+      </annotation>
+      <annotation id="1020">
+        <infon key="type">site</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:00:00Z</infon>
+        <location offset="18901" length="18"/>
+        <text>subsites −2 and −3</text>
+      </annotation>
+      <annotation id="490">
+        <infon key="score">0.9847268</infon>
+        <infon key="type">bond_interaction</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:26:03Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="18945" length="19"/>
+        <text>hydrophobic contact</text>
+      </annotation>
+      <annotation id="491">
+        <infon key="score">0.9995246</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:06:30Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="18970" length="6"/>
+        <text>Val318</text>
+      </annotation>
+      <annotation id="492">
+        <infon key="score">0.8751849</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:00:03Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="18982" length="2"/>
+        <text>−3</text>
+      </annotation>
+      <annotation id="493">
+        <infon key="score">0.9987112</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:02Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="18985" length="4"/>
+        <text>Xylp</text>
+      </annotation>
+      <annotation id="1021">
+        <infon key="type">bond_interaction</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:00:26Z</infon>
+        <location offset="18996" length="26"/>
+        <text>planar apolar interactions</text>
+      </annotation>
+      <annotation id="494">
+        <infon key="score">0.99950683</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:06:33Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="19028" length="6"/>
+        <text>Ala137</text>
+      </annotation>
+      <annotation id="495">
+        <infon key="score">0.99882287</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:34Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="19048" length="6"/>
+        <text>xylose</text>
+      </annotation>
+      <annotation id="496">
+        <infon key="score">0.65771174</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:00:33Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="19058" length="2"/>
+        <text>−4</text>
+      </annotation>
+      <annotation id="1029">
+        <infon key="type">bond_interaction</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:06:50Z</infon>
+        <location offset="19067" length="24"/>
+        <text>parallel apolar contacts</text>
+      </annotation>
+      <annotation id="497">
+        <infon key="score">0.99949133</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:06:36Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="19097" length="5"/>
+        <text>Trp69</text>
+      </annotation>
+      <annotation id="498">
+        <infon key="score">0.9983335</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:00:44Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="19129" length="17"/>
+        <text>negative subsites</text>
+      </annotation>
+      <annotation id="499">
+        <infon key="score">0.9988159</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:31Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="19150" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="500">
+        <infon key="score">0.9990707</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:45:23Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="19163" length="7"/>
+        <text>BaCel5A</text>
+      </annotation>
+      <annotation id="501">
+        <infon key="score">0.9989895</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:31:50Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="19185" length="4"/>
+        <text>GH10</text>
+      </annotation>
+      <annotation id="502">
+        <infon key="score">0.9976179</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:35:03Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="19190" length="8"/>
+        <text>xylanase</text>
+      </annotation>
+      <annotation id="503">
+        <infon key="score">0.9923934</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:45:27Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="19200" length="8"/>
+        <text>CmXyn10B</text>
+      </annotation>
+      <annotation id="504">
+        <infon key="score">0.99495846</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:57Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="19276" length="15"/>
+        <text>arabinoxylanase</text>
+      </annotation>
+      <annotation id="505">
+        <infon key="score">0.9988996</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:27:57Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="19323" length="11"/>
+        <text>active site</text>
+      </annotation>
+      <annotation id="506">
+        <infon key="score">0.99886346</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:26:17Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="19355" length="9"/>
+        <text>cellulase</text>
+      </annotation>
+      <annotation id="507">
+        <infon key="score">0.9983138</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:00:38Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="19380" length="17"/>
+        <text>negative subsites</text>
+      </annotation>
+      <annotation id="508">
+        <infon key="score">0.98889786</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:42:36Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="19406" length="6"/>
+        <text>sugars</text>
+      </annotation>
+      <annotation id="509">
+        <infon key="score">0.98305774</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:33:46Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="19413" length="8"/>
+        <text>bound in</text>
+      </annotation>
+      <annotation id="510">
+        <infon key="score">0.9832241</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:00:48Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="19426" length="18"/>
+        <text>−2 and −3 subsites</text>
+      </annotation>
+      <annotation id="511">
+        <infon key="score">0.9674461</infon>
+        <infon key="type">bond_interaction</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:26:11Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="19463" length="18"/>
+        <text>polar interactions</text>
+      </annotation>
+      <annotation id="512">
+        <infon key="score">0.99883157</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:31:50Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="19521" length="4"/>
+        <text>GH10</text>
+      </annotation>
+      <annotation id="513">
+        <infon key="score">0.99209</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:35:16Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="19526" length="8"/>
+        <text>xylanase</text>
+      </annotation>
+      <annotation id="514">
+        <infon key="score">0.99729645</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:00:53Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="19551" length="10"/>
+        <text>−2 subsite</text>
+      </annotation>
+      <annotation id="515">
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+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:26:17Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="19583" length="9"/>
+        <text>cellulase</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">RESULTS</infon>
+      <infon key="type">title_4</infon>
+      <offset>19682</offset>
+      <text>The Influence of the Modular Architecture of CtXyl5A on Catalytic Activity</text>
+      <annotation id="516">
+        <infon key="score">0.98137945</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
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+        <infon key="identifier">PR:</infon>
+        <location offset="19727" length="7"/>
+        <text>CtXyl5A</text>
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+    </passage>
+    <passage>
+      <infon key="section_type">RESULTS</infon>
+      <infon key="type">paragraph</infon>
+      <offset>19757</offset>
+      <text>CtXyl5A, in addition to its catalytic module, contains three CBMs (CtCBM6, CtCBM13, and CtCBM62) and a fibronectin domain (CtFn3). A previous study showed that although the CBM6 bound in an exo-mode to xylo- and cellulooligosaccharides, the primary role of this module was to stabilize the structure of the GH5 catalytic module. To explore the contribution of the other non-catalytic modules to CtXyl5A function, the activity of a series of truncated derivatives of the arabinoxylanase were assessed. The data in Table 1 show that removal of CtCBM62 caused a modest increase in activity against both WAX and CX, whereas deletion of the Fn3 domain had no further impact on catalytic performance. Truncation of CtCBM13, however, caused a 4–5-fold reduction in activity against both substrates. Members of CBM13 have been shown to bind to xylans, mannose, and galactose residues in complex glycans, hinting that the function of CtCBM13 is to increase the proximity of substrate to the catalytic module of CtXyl5A. Binding studies, however, showed that CtCBM13 displayed no affinity for a range of relevant glycans including WAX, CX, xylose, mannose, galactose, and birchwood xylan (BX) (data not shown). It would appear, therefore, that CtCBM13 makes a structural contribution to the function of CtXyl5A.</text>
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+        <infon key="annotator">cleaner0</infon>
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+        <infon key="identifier">PR:</infon>
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+        <text>CtXyl5A</text>
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+        <infon key="identifier">SO:</infon>
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+        <text>catalytic module</text>
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+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
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+        <infon key="identifier">SO:</infon>
+        <location offset="19818" length="4"/>
+        <text>CBMs</text>
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+      <annotation id="520">
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+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:40Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="19824" length="6"/>
+        <text>CtCBM6</text>
+      </annotation>
+      <annotation id="521">
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+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:04Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="19832" length="7"/>
+        <text>CtCBM13</text>
+      </annotation>
+      <annotation id="522">
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+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:36Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="19845" length="7"/>
+        <text>CtCBM62</text>
+      </annotation>
+      <annotation id="523">
+        <infon key="score">0.9989512</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:51:47Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="19860" length="18"/>
+        <text>fibronectin domain</text>
+      </annotation>
+      <annotation id="524">
+        <infon key="score">0.99350643</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:45:53Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="19880" length="5"/>
+        <text>CtFn3</text>
+      </annotation>
+      <annotation id="525">
+        <infon key="score">0.9994</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:51:34Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="19930" length="4"/>
+        <text>CBM6</text>
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+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:33:46Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="19935" length="8"/>
+        <text>bound in</text>
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+      <annotation id="527">
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+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:36:32Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="19947" length="8"/>
+        <text>exo-mode</text>
+      </annotation>
+      <annotation id="528">
+        <infon key="score">0.986774</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:42:44Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="19959" length="33"/>
+        <text>xylo- and cellulooligosaccharides</text>
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+      <annotation id="529">
+        <infon key="score">0.99714065</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:40:58Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="20064" length="3"/>
+        <text>GH5</text>
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+      <annotation id="530">
+        <infon key="score">0.99528027</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:35:55Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="20068" length="16"/>
+        <text>catalytic module</text>
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+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:51:52Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="20127" length="21"/>
+        <text>non-catalytic modules</text>
+      </annotation>
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+        <infon key="score">0.99911505</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:31Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="20152" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="1032">
+        <infon key="type">protein_state</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:08:05Z</infon>
+        <location offset="20198" length="9"/>
+        <text>truncated</text>
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+      <annotation id="533">
+        <infon key="score">0.99889565</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:57Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="20227" length="15"/>
+        <text>arabinoxylanase</text>
+      </annotation>
+      <annotation id="534">
+        <infon key="score">0.96990776</infon>
+        <infon key="type">experimental_method</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:26:35Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="20288" length="10"/>
+        <text>removal of</text>
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+      <annotation id="535">
+        <infon key="score">0.7631579</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:36Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="20299" length="7"/>
+        <text>CtCBM62</text>
+      </annotation>
+      <annotation id="536">
+        <infon key="score">0.99899715</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:45:23Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="20357" length="3"/>
+        <text>WAX</text>
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+      <annotation id="537">
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+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:46:39Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="20365" length="2"/>
+        <text>CX</text>
+      </annotation>
+      <annotation id="538">
+        <infon key="score">0.8609744</infon>
+        <infon key="type">experimental_method</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:26:40Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="20377" length="11"/>
+        <text>deletion of</text>
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+      <annotation id="539">
+        <infon key="score">0.9990049</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:38:04Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="20393" length="3"/>
+        <text>Fn3</text>
+      </annotation>
+      <annotation id="540">
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+        <infon key="type">experimental_method</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:26:38Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="20452" length="10"/>
+        <text>Truncation</text>
+      </annotation>
+      <annotation id="541">
+        <infon key="score">0.99084926</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:04Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="20466" length="7"/>
+        <text>CtCBM13</text>
+      </annotation>
+      <annotation id="542">
+        <infon key="score">0.979066</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:52:05Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="20560" length="5"/>
+        <text>CBM13</text>
+      </annotation>
+      <annotation id="543">
+        <infon key="score">0.9990688</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:32Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="20593" length="6"/>
+        <text>xylans</text>
+      </annotation>
+      <annotation id="544">
+        <infon key="score">0.99915814</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:42:49Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="20601" length="7"/>
+        <text>mannose</text>
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+      <annotation id="545">
+        <infon key="score">0.9989704</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:42:52Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="20614" length="9"/>
+        <text>galactose</text>
+      </annotation>
+      <annotation id="546">
+        <infon key="score">0.777462</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:42:54Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="20636" length="15"/>
+        <text>complex glycans</text>
+      </annotation>
+      <annotation id="547">
+        <infon key="score">0.9620865</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:04Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="20682" length="7"/>
+        <text>CtCBM13</text>
+      </annotation>
+      <annotation id="548">
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+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:35:55Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="20739" length="16"/>
+        <text>catalytic module</text>
+      </annotation>
+      <annotation id="549">
+        <infon key="score">0.9991768</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:31Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="20759" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="550">
+        <infon key="score">0.9986268</infon>
+        <infon key="type">experimental_method</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:26:43Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="20768" length="15"/>
+        <text>Binding studies</text>
+      </annotation>
+      <annotation id="551">
+        <infon key="score">0.9760868</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:04Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="20806" length="7"/>
+        <text>CtCBM13</text>
+      </annotation>
+      <annotation id="552">
+        <infon key="score">0.99847585</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:42:57Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="20860" length="7"/>
+        <text>glycans</text>
+      </annotation>
+      <annotation id="553">
+        <infon key="score">0.99904245</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:45:24Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="20878" length="3"/>
+        <text>WAX</text>
+      </annotation>
+      <annotation id="554">
+        <infon key="score">0.99910945</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:46:39Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="20883" length="2"/>
+        <text>CX</text>
+      </annotation>
+      <annotation id="555">
+        <infon key="score">0.999185</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:34Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="20887" length="6"/>
+        <text>xylose</text>
+      </annotation>
+      <annotation id="556">
+        <infon key="score">0.9991738</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:43:00Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="20895" length="7"/>
+        <text>mannose</text>
+      </annotation>
+      <annotation id="557">
+        <infon key="score">0.99903405</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:43:03Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="20904" length="9"/>
+        <text>galactose</text>
+      </annotation>
+      <annotation id="558">
+        <infon key="score">0.99697894</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:26:57Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="20919" length="15"/>
+        <text>birchwood xylan</text>
+      </annotation>
+      <annotation id="559">
+        <infon key="score">0.9985886</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:43:07Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="20936" length="2"/>
+        <text>BX</text>
+      </annotation>
+      <annotation id="560">
+        <infon key="score">0.9839033</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:04Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="20991" length="7"/>
+        <text>CtCBM13</text>
+      </annotation>
+      <annotation id="561">
+        <infon key="score">0.99899536</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:31Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="21050" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">RESULTS</infon>
+      <infon key="type">title_4</infon>
+      <offset>21061</offset>
+      <text>Crystal Structure of CtXyl5A-D</text>
+      <annotation id="562">
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+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:49Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="21061" length="17"/>
+        <text>Crystal Structure</text>
+      </annotation>
+      <annotation id="563">
+        <infon key="score">0.9985922</infon>
+        <infon key="type">mutant</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:27:42Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="21082" length="9"/>
+        <text>CtXyl5A-D</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">RESULTS</infon>
+      <infon key="type">paragraph</infon>
+      <offset>21092</offset>
+      <text>To explore further the role of the non-catalytic modules in CtXyl5A the crystal structure of CtXyl5A extending from CtGH5 to CtCBM62 was sought. To obtain a construct that could potentially be crystallized, the protein was generated without the C-terminal dockerin domain because it is known to be unstable and prone to cleavage. Using this construct (CtXyl5A-D) the crystal structure of the arabinoxylanase was determined by molecular replacement to a resolution of 2.64 Å with Rwork and Rfree at 23.7% and 27.8%, respectively. The structure comprises a continuous polypeptide extending from Ala36 to Trp742 displaying four modules GH5-CBM6-CBM13-Fn3. Although there was some electron density for CtCBM62, it was not sufficient to confidently build the module (Fig. 5). Further investigation of the crystal packing revealed a large solvent channel adjacent to the area the CBM62 occupies. We postulate that the reason for the poor electron density is due to the CtCBM62 being mobile compared with the rest of the protein. The structures of CtGH5 and CtCBM6 have been described previously.</text>
+      <annotation id="564">
+        <infon key="score">0.99891555</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:51:56Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="21127" length="21"/>
+        <text>non-catalytic modules</text>
+      </annotation>
+      <annotation id="565">
+        <infon key="score">0.99892277</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:31Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="21152" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="566">
+        <infon key="score">0.99893296</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:49Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="21164" length="17"/>
+        <text>crystal structure</text>
+      </annotation>
+      <annotation id="567">
+        <infon key="score">0.9983997</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:31Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="21185" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="568">
+        <infon key="score">0.7888786</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:02Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="21208" length="5"/>
+        <text>CtGH5</text>
+      </annotation>
+      <annotation id="569">
+        <infon key="score">0.4889835</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:36Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="21217" length="7"/>
+        <text>CtCBM62</text>
+      </annotation>
+      <annotation id="570">
+        <infon key="score">0.94939154</infon>
+        <infon key="type">experimental_method</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:05:54Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="21285" length="12"/>
+        <text>crystallized</text>
+      </annotation>
+      <annotation id="571">
+        <infon key="score">0.9952478</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:36:36Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="21325" length="7"/>
+        <text>without</text>
+      </annotation>
+      <annotation id="909">
+        <infon key="type">structure_element</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:38:10Z</infon>
+        <location offset="21348" length="8"/>
+        <text>dockerin</text>
+      </annotation>
+      <annotation id="572">
+        <infon key="score">0.9989806</infon>
+        <infon key="type">mutant</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:27:42Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="21444" length="9"/>
+        <text>CtXyl5A-D</text>
+      </annotation>
+      <annotation id="573">
+        <infon key="score">0.9989059</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:49Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="21459" length="17"/>
+        <text>crystal structure</text>
+      </annotation>
+      <annotation id="574">
+        <infon key="score">0.9990243</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:57Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="21484" length="15"/>
+        <text>arabinoxylanase</text>
+      </annotation>
+      <annotation id="575">
+        <infon key="score">0.99872184</infon>
+        <infon key="type">experimental_method</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:06:00Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="21518" length="21"/>
+        <text>molecular replacement</text>
+      </annotation>
+      <annotation id="576">
+        <infon key="score">0.9985116</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:28:04Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="21571" length="5"/>
+        <text>Rwork</text>
+      </annotation>
+      <annotation id="577">
+        <infon key="score">0.99814725</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:28:06Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="21581" length="5"/>
+        <text>Rfree</text>
+      </annotation>
+      <annotation id="578">
+        <infon key="score">0.99822944</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:27:58Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="21625" length="9"/>
+        <text>structure</text>
+      </annotation>
+      <annotation id="579">
+        <infon key="score">0.967706</infon>
+        <infon key="type">residue_range</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:28:13Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="21685" length="15"/>
+        <text>Ala36 to Trp742</text>
+      </annotation>
+      <annotation id="1045">
+        <infon key="type">structure_element</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:31:31Z</infon>
+        <location offset="21725" length="18"/>
+        <text>GH5-CBM6-CBM13-Fn3</text>
+      </annotation>
+      <annotation id="580">
+        <infon key="score">0.998767</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:27:52Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="21769" length="16"/>
+        <text>electron density</text>
+      </annotation>
+      <annotation id="581">
+        <infon key="score">0.86748755</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:36Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="21790" length="7"/>
+        <text>CtCBM62</text>
+      </annotation>
+      <annotation id="1022">
+        <infon key="type">evidence</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:01:19Z</infon>
+        <location offset="21892" length="15"/>
+        <text>crystal packing</text>
+      </annotation>
+      <annotation id="582">
+        <infon key="score">0.9981135</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:01:00Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="21925" length="15"/>
+        <text>solvent channel</text>
+      </annotation>
+      <annotation id="583">
+        <infon key="score">0.61647874</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:52:00Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="21966" length="5"/>
+        <text>CBM62</text>
+      </annotation>
+      <annotation id="584">
+        <infon key="score">0.99834853</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:28:08Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="22024" length="16"/>
+        <text>electron density</text>
+      </annotation>
+      <annotation id="585">
+        <infon key="score">0.85926026</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:36Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="22055" length="7"/>
+        <text>CtCBM62</text>
+      </annotation>
+      <annotation id="586">
+        <infon key="score">0.8196963</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:36:40Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="22069" length="6"/>
+        <text>mobile</text>
+      </annotation>
+      <annotation id="587">
+        <infon key="score">0.9980434</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:27:55Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="22119" length="10"/>
+        <text>structures</text>
+      </annotation>
+      <annotation id="588">
+        <infon key="score">0.9983726</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:02Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="22133" length="5"/>
+        <text>CtGH5</text>
+      </annotation>
+      <annotation id="589">
+        <infon key="score">0.9979448</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:41Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="22143" length="6"/>
+        <text>CtCBM6</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="file">zbc0441653440005.jpg</infon>
+      <infon key="id">F5</infon>
+      <infon key="section_type">FIG</infon>
+      <infon key="type">fig_caption</infon>
+      <offset>22184</offset>
+      <text>Surface representation of the tetra-modular arabinoxylanase and zoom view on the CtGH5 loop. The blue module is the CtGH5 catalytic domain, the green module corresponds to the CtCBM6, the yellow module is the CtCBM13, and the salmon module is the fibronectin domain. Surfaces are semitransparent with the protein backbone represented as a cartoon. The CtGH5 loop is stabilized between the CtCBM6 and the CtCBM13 modules. The black dashes represent the hydrogen bonds. The protein backbone is represented as cartoon, and interacting residues are shown as sticks.</text>
+      <annotation id="590">
+        <infon key="score">0.9992005</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:58Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="22228" length="15"/>
+        <text>arabinoxylanase</text>
+      </annotation>
+      <annotation id="591">
+        <infon key="score">0.99799275</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:02Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="22265" length="5"/>
+        <text>CtGH5</text>
+      </annotation>
+      <annotation id="592">
+        <infon key="score">0.9989273</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:34:53Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="22271" length="4"/>
+        <text>loop</text>
+      </annotation>
+      <annotation id="593">
+        <infon key="score">0.9980647</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:02Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="22300" length="5"/>
+        <text>CtGH5</text>
+      </annotation>
+      <annotation id="594">
+        <infon key="score">0.9991582</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:20Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="22306" length="16"/>
+        <text>catalytic domain</text>
+      </annotation>
+      <annotation id="595">
+        <infon key="score">0.9944258</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:41Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="22360" length="6"/>
+        <text>CtCBM6</text>
+      </annotation>
+      <annotation id="596">
+        <infon key="score">0.9965469</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:05Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="22393" length="7"/>
+        <text>CtCBM13</text>
+      </annotation>
+      <annotation id="597">
+        <infon key="score">0.99827754</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:52:05Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="22431" length="18"/>
+        <text>fibronectin domain</text>
+      </annotation>
+      <annotation id="598">
+        <infon key="score">0.99751484</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:02Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="22536" length="5"/>
+        <text>CtGH5</text>
+      </annotation>
+      <annotation id="599">
+        <infon key="score">0.99883205</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:52:09Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="22542" length="4"/>
+        <text>loop</text>
+      </annotation>
+      <annotation id="600">
+        <infon key="score">0.9829196</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:41Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="22573" length="6"/>
+        <text>CtCBM6</text>
+      </annotation>
+      <annotation id="601">
+        <infon key="score">0.9829951</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:05Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="22588" length="7"/>
+        <text>CtCBM13</text>
+      </annotation>
+      <annotation id="602">
+        <infon key="score">0.99495596</infon>
+        <infon key="type">bond_interaction</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:19:58Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="22636" length="14"/>
+        <text>hydrogen bonds</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">RESULTS</infon>
+      <infon key="type">paragraph</infon>
+      <offset>22746</offset>
+      <text>CtCBM13 extends from Gly567 to Pro648. Typical of CBM13 proteins CtCBM13 displays a β-trefoil fold comprising the canonical pseudo 3-fold symmetry with a 3-fold repeating unit of 40–50 amino acid residues characteristic of the Ricin superfamily. Each repeat contains two pairs of antiparallel β-strands. A Dali search revealed structural homologs from the CBM13 family with an root mean square deviation less than 2.0 Å and sequence identities of less than 20% that include the functionally relevant homologs C. thermocellum exo-β-1,3-galactanase (PDB code 3vsz), Streptomyces avermitilis β-l-arabinopyranosidase (PDB code 3a21), Streptomyces lividans xylanase 10A (PDB code, 1mc9), and Streptomyces olivaceoviridis E-86 xylanase 10A (PDB code 1v6v).</text>
+      <annotation id="603">
+        <infon key="score">0.9912047</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:05Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="22746" length="7"/>
+        <text>CtCBM13</text>
+      </annotation>
+      <annotation id="604">
+        <infon key="score">0.79160744</infon>
+        <infon key="type">residue_range</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:29:19Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="22767" length="16"/>
+        <text>Gly567 to Pro648</text>
+      </annotation>
+      <annotation id="940">
+        <infon key="type">protein_type</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:29:04Z</infon>
+        <location offset="22796" length="5"/>
+        <text>CBM13</text>
+      </annotation>
+      <annotation id="605">
+        <infon key="score">0.97495085</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:05Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="22811" length="7"/>
+        <text>CtCBM13</text>
+      </annotation>
+      <annotation id="606">
+        <infon key="score">0.99881685</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:32:18Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="22830" length="14"/>
+        <text>β-trefoil fold</text>
+      </annotation>
+      <annotation id="607">
+        <infon key="score">0.99027336</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:52:13Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="22900" length="21"/>
+        <text>3-fold repeating unit</text>
+      </annotation>
+      <annotation id="608">
+        <infon key="score">0.78913796</infon>
+        <infon key="type">residue_range</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:29:24Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="22925" length="16"/>
+        <text>40–50 amino acid</text>
+      </annotation>
+      <annotation id="609">
+        <infon key="score">0.998422</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:35:21Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="22973" length="17"/>
+        <text>Ricin superfamily</text>
+      </annotation>
+      <annotation id="610">
+        <infon key="score">0.8408495</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:52:19Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="22997" length="6"/>
+        <text>repeat</text>
+      </annotation>
+      <annotation id="611">
+        <infon key="score">0.9983705</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:32:15Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="23026" length="22"/>
+        <text>antiparallel β-strands</text>
+      </annotation>
+      <annotation id="612">
+        <infon key="score">0.9987341</infon>
+        <infon key="type">experimental_method</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:06:09Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="23052" length="11"/>
+        <text>Dali search</text>
+      </annotation>
+      <annotation id="941">
+        <infon key="type">protein_type</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:29:39Z</infon>
+        <location offset="23102" length="5"/>
+        <text>CBM13</text>
+      </annotation>
+      <annotation id="613">
+        <infon key="score">0.998098</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:31:37Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="23123" length="26"/>
+        <text>root mean square deviation</text>
+      </annotation>
+      <annotation id="614">
+        <infon key="score">0.99859744</infon>
+        <infon key="type">species</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:38:26Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="23255" length="15"/>
+        <text>C. thermocellum</text>
+      </annotation>
+      <annotation id="955">
+        <infon key="type">protein_type</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:30:06Z</infon>
+        <location offset="23271" length="21"/>
+        <text>exo-β-1,3-galactanase</text>
+      </annotation>
+      <annotation id="615">
+        <infon key="score">0.9984226</infon>
+        <infon key="type">species</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:30:13Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="23310" length="24"/>
+        <text>Streptomyces avermitilis</text>
+      </annotation>
+      <annotation id="956">
+        <infon key="type">protein_type</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:30:39Z</infon>
+        <location offset="23335" length="23"/>
+        <text>β-l-arabinopyranosidase</text>
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+      <annotation id="616">
+        <infon key="score">0.9983331</infon>
+        <infon key="type">species</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:30:17Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="23376" length="21"/>
+        <text>Streptomyces lividans</text>
+      </annotation>
+      <annotation id="617">
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+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:47:34Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="23398" length="12"/>
+        <text>xylanase 10A</text>
+      </annotation>
+      <annotation id="1010">
+        <infon key="type">species</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:49:01Z</infon>
+        <location offset="23433" length="33"/>
+        <text>Streptomyces olivaceoviridis E-86</text>
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+      <annotation id="618">
+        <infon key="score">0.7191514</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:49:07Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="23467" length="12"/>
+        <text>xylanase 10A</text>
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+    </passage>
+    <passage>
+      <infon key="section_type">RESULTS</infon>
+      <infon key="type">paragraph</infon>
+      <offset>23509</offset>
+      <text>The Fn3 module displays a typical β-sandwich fold with the two sheets comprising, primarily, three antiparallel strands in the order β1-β2-β5 in β-sheet 1 and β4-β3-β6 in β-sheet 2. Although β-sheet 2 presents a cleft-like topology, typical of endo-binding CBMs, the surface lacks aromatic residues that play a key role in ligand recognition, and in the context of the full-length enzyme, the cleft abuts into CtCBM13 and thus would not be able to accommodate an extended polysaccharide chain (see below).</text>
+      <annotation id="906">
+        <infon key="type">structure_element</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:38:04Z</infon>
+        <location offset="23513" length="3"/>
+        <text>Fn3</text>
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+      <annotation id="619">
+        <infon key="score">0.9970993</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:32:51Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="23543" length="15"/>
+        <text>β-sandwich fold</text>
+      </annotation>
+      <annotation id="1014">
+        <infon key="type">structure_element</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:52:42Z</infon>
+        <location offset="23572" length="6"/>
+        <text>sheets</text>
+      </annotation>
+      <annotation id="620">
+        <infon key="score">0.9945593</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:52:48Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="23608" length="20"/>
+        <text>antiparallel strands</text>
+      </annotation>
+      <annotation id="621">
+        <infon key="score">0.99866545</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:32:37Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="23642" length="8"/>
+        <text>β1-β2-β5</text>
+      </annotation>
+      <annotation id="622">
+        <infon key="score">0.9991293</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:32:40Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="23654" length="9"/>
+        <text>β-sheet 1</text>
+      </annotation>
+      <annotation id="623">
+        <infon key="score">0.9986183</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:32:42Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="23668" length="8"/>
+        <text>β4-β3-β6</text>
+      </annotation>
+      <annotation id="624">
+        <infon key="score">0.99922734</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:32:44Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="23680" length="9"/>
+        <text>β-sheet 2</text>
+      </annotation>
+      <annotation id="625">
+        <infon key="score">0.999304</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:32:47Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="23700" length="9"/>
+        <text>β-sheet 2</text>
+      </annotation>
+      <annotation id="626">
+        <infon key="score">0.6592578</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:01:28Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="23721" length="5"/>
+        <text>cleft</text>
+      </annotation>
+      <annotation id="627">
+        <infon key="score">0.732665</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:31:58Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="23753" length="17"/>
+        <text>endo-binding CBMs</text>
+      </annotation>
+      <annotation id="628">
+        <infon key="score">0.9990554</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:07:19Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="23878" length="11"/>
+        <text>full-length</text>
+      </annotation>
+      <annotation id="629">
+        <infon key="score">0.66877615</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:49:11Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="23890" length="6"/>
+        <text>enzyme</text>
+      </annotation>
+      <annotation id="630">
+        <infon key="score">0.9982305</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:01:38Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="23902" length="5"/>
+        <text>cleft</text>
+      </annotation>
+      <annotation id="631">
+        <infon key="score">0.998874</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:05Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="23919" length="7"/>
+        <text>CtCBM13</text>
+      </annotation>
+      <annotation id="632">
+        <infon key="score">0.9986582</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:28:43Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="23981" length="14"/>
+        <text>polysaccharide</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">RESULTS</infon>
+      <infon key="type">paragraph</infon>
+      <offset>24045</offset>
+      <text>In the structure of CtXyl5A-D, the four modules form a three-leaf clover-like structure (Fig. 5). Between the interfaces of CtGH5-CBM6-CBM13 there are a number of interactions that maintain the modules in a fixed position relative to each other. The interaction of CtGH5 and CtCBM6, which buries a substantial apolar solvent-exposed surface of the two modules, has been described previously. The polar interactions between these two modules comprise 14 hydrogen bonds and 5 salt bridges. The apolar and polar interactions between these two modules likely explaining why they do not fold independently compared with other glycoside hydrolases that contain CBMs. CtCBM13 acts as the central domain, which interacts with CtGH5, CtCBM6, and CtFn3 via 2, 5, and 4 hydrogen bonds, respectively, burying a surface area of ∼450, 350, and 500 Å2, respectively, to form a compact heterotetramer. With respect to the CtCBM6-CBM13 interface, the linker (SPISTGTIP) between the two modules, extending from Ser514 to Pro522, adopts a fixed conformation. Such sequences are normally extremely flexible; however, the two Ile residues make extensive apolar contacts within the linker and with the two CBMs, leading to conformational stabilization. The interactions between CtGH5 and the two CBMs, which are mediated by the tip of the loop between β-7 and α-7 (loop 7) of CtGH5, not only stabilize the trimodular clover-like structure but also make a contribution to catalytic function. Central to the interactions between the three modules is Trp285, which is intercalated between the two CBMs. The Nϵ of this aromatic residue makes hydrogen bonds with the backbone carbonyl of Val615 and Gly616 in CtCBM13, and the indole ring makes several apolar contacts with CtCBM6 (Pro440, Phe489, Gly491, and Ala492) (Fig. 5). Indeed, loop 7 is completely disordered in the truncated derivative of CtXyl5A comprising CtGH5 and CtCBM6, demonstrating that the interactions with CtCBM13 stabilize the conformation of this loop. Although the tip of loop 7 does not directly contribute to the topology of the active site, it is only ∼12 Å from the catalytic nucleophile Glu279. Thus, any perturbation of the loop (through the removal of CtCBM13) is likely to influence the electrostatic and apolar environment of the catalytic apparatus, which could explain the reduction in activity associated with the deletion of CtCBM13.</text>
+      <annotation id="633">
+        <infon key="score">0.99554837</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:51:06Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="24052" length="9"/>
+        <text>structure</text>
+      </annotation>
+      <annotation id="634">
+        <infon key="score">0.99779385</infon>
+        <infon key="type">mutant</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:27:42Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="24065" length="9"/>
+        <text>CtXyl5A-D</text>
+      </annotation>
+      <annotation id="635">
+        <infon key="score">0.7459186</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:52:53Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="24085" length="7"/>
+        <text>modules</text>
+      </annotation>
+      <annotation id="636">
+        <infon key="score">0.9990779</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:01:43Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="24155" length="10"/>
+        <text>interfaces</text>
+      </annotation>
+      <annotation id="1046">
+        <infon key="type">structure_element</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:32:00Z</infon>
+        <location offset="24169" length="16"/>
+        <text>CtGH5-CBM6-CBM13</text>
+      </annotation>
+      <annotation id="637">
+        <infon key="score">0.9977719</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:02Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="24310" length="5"/>
+        <text>CtGH5</text>
+      </annotation>
+      <annotation id="638">
+        <infon key="score">0.99530184</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:41Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="24320" length="6"/>
+        <text>CtCBM6</text>
+      </annotation>
+      <annotation id="1023">
+        <infon key="type">site</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:02:09Z</infon>
+        <location offset="24355" length="30"/>
+        <text>apolar solvent-exposed surface</text>
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+      <annotation id="639">
+        <infon key="score">0.9960426</infon>
+        <infon key="type">bond_interaction</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:26:11Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="24441" length="18"/>
+        <text>polar interactions</text>
+      </annotation>
+      <annotation id="640">
+        <infon key="score">0.99697936</infon>
+        <infon key="type">bond_interaction</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:19:58Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="24498" length="14"/>
+        <text>hydrogen bonds</text>
+      </annotation>
+      <annotation id="641">
+        <infon key="score">0.9962404</infon>
+        <infon key="type">bond_interaction</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:10:23Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="24519" length="12"/>
+        <text>salt bridges</text>
+      </annotation>
+      <annotation id="1024">
+        <infon key="type">bond_interaction</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:02:27Z</infon>
+        <location offset="24537" length="29"/>
+        <text>apolar and polar interactions</text>
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+      <annotation id="642">
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+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:30:28Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="24666" length="20"/>
+        <text>glycoside hydrolases</text>
+      </annotation>
+      <annotation id="643">
+        <infon key="score">0.99762887</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:12Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="24700" length="4"/>
+        <text>CBMs</text>
+      </annotation>
+      <annotation id="644">
+        <infon key="score">0.9972363</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:05Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="24706" length="7"/>
+        <text>CtCBM13</text>
+      </annotation>
+      <annotation id="645">
+        <infon key="score">0.99929976</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:34:12Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="24726" length="14"/>
+        <text>central domain</text>
+      </annotation>
+      <annotation id="996">
+        <infon key="type">protein_state</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:37:21Z</infon>
+        <location offset="24748" length="14"/>
+        <text>interacts with</text>
+      </annotation>
+      <annotation id="646">
+        <infon key="score">0.9982716</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:02Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="24763" length="5"/>
+        <text>CtGH5</text>
+      </annotation>
+      <annotation id="647">
+        <infon key="score">0.9980007</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:41Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="24770" length="6"/>
+        <text>CtCBM6</text>
+      </annotation>
+      <annotation id="648">
+        <infon key="score">0.998733</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:33:43Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="24782" length="5"/>
+        <text>CtFn3</text>
+      </annotation>
+      <annotation id="649">
+        <infon key="score">0.99688613</infon>
+        <infon key="type">bond_interaction</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:19:58Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="24804" length="14"/>
+        <text>hydrogen bonds</text>
+      </annotation>
+      <annotation id="650">
+        <infon key="score">0.99871945</infon>
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+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:37:41Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="24907" length="7"/>
+        <text>compact</text>
+      </annotation>
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+        <infon key="type">oligomeric_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:37:35Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="24915" length="14"/>
+        <text>heterotetramer</text>
+      </annotation>
+      <annotation id="652">
+        <infon key="score">0.9980378</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:33:28Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="24951" length="22"/>
+        <text>CtCBM6-CBM13 interface</text>
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+        <infon key="score">0.9993907</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:34:15Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="24979" length="6"/>
+        <text>linker</text>
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+        <infon key="score">0.99948835</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:06:17Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="24987" length="9"/>
+        <text>SPISTGTIP</text>
+      </annotation>
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+        <infon key="score">0.9606576</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:52:56Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="25014" length="7"/>
+        <text>modules</text>
+      </annotation>
+      <annotation id="656">
+        <infon key="score">0.99290574</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:08:18Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="25038" length="6"/>
+        <text>Ser514</text>
+      </annotation>
+      <annotation id="657">
+        <infon key="score">0.9987361</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:08:21Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="25048" length="6"/>
+        <text>Pro522</text>
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+      <annotation id="658">
+        <infon key="score">0.88606876</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:37:47Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="25065" length="18"/>
+        <text>fixed conformation</text>
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+      <annotation id="659">
+        <infon key="score">0.9965569</infon>
+        <infon key="type">residue_name</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:34:08Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="25150" length="3"/>
+        <text>Ile</text>
+      </annotation>
+      <annotation id="1026">
+        <infon key="type">bond_interaction</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:03:28Z</infon>
+        <location offset="25178" length="15"/>
+        <text>apolar contacts</text>
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+      <annotation id="660">
+        <infon key="score">0.9991703</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:34:48Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="25205" length="6"/>
+        <text>linker</text>
+      </annotation>
+      <annotation id="661">
+        <infon key="score">0.9988801</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:12Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="25229" length="4"/>
+        <text>CBMs</text>
+      </annotation>
+      <annotation id="662">
+        <infon key="score">0.99847704</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:02Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="25301" length="5"/>
+        <text>CtGH5</text>
+      </annotation>
+      <annotation id="663">
+        <infon key="score">0.99815255</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:13Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="25319" length="4"/>
+        <text>CBMs</text>
+      </annotation>
+      <annotation id="664">
+        <infon key="score">0.99904627</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:33:53Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="25362" length="4"/>
+        <text>loop</text>
+      </annotation>
+      <annotation id="665">
+        <infon key="score">0.99917275</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:33:59Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="25375" length="3"/>
+        <text>β-7</text>
+      </annotation>
+      <annotation id="666">
+        <infon key="score">0.99806833</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:34:01Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="25383" length="3"/>
+        <text>α-7</text>
+      </annotation>
+      <annotation id="667">
+        <infon key="score">0.9991961</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:33:56Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="25388" length="6"/>
+        <text>loop 7</text>
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+      <annotation id="668">
+        <infon key="score">0.9988186</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:02Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="25399" length="5"/>
+        <text>CtGH5</text>
+      </annotation>
+      <annotation id="994">
+        <infon key="type">structure_element</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:05:50Z</infon>
+        <location offset="25429" length="17"/>
+        <text>trimodular clover</text>
+      </annotation>
+      <annotation id="669">
+        <infon key="score">0.5572531</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:53:02Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="25560" length="7"/>
+        <text>modules</text>
+      </annotation>
+      <annotation id="670">
+        <infon key="score">0.99958736</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:34:40Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="25571" length="6"/>
+        <text>Trp285</text>
+      </annotation>
+      <annotation id="1033">
+        <infon key="type">bond_interaction</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:08:51Z</infon>
+        <location offset="25588" length="20"/>
+        <text>intercalated between</text>
+      </annotation>
+      <annotation id="671">
+        <infon key="score">0.99859947</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:13Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="25617" length="4"/>
+        <text>CBMs</text>
+      </annotation>
+      <annotation id="672">
+        <infon key="score">0.997342</infon>
+        <infon key="type">bond_interaction</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:19:58Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="25661" length="14"/>
+        <text>hydrogen bonds</text>
+      </annotation>
+      <annotation id="673">
+        <infon key="score">0.99960214</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:34:35Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="25706" length="6"/>
+        <text>Val615</text>
+      </annotation>
+      <annotation id="674">
+        <infon key="score">0.9995946</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:34:37Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="25717" length="6"/>
+        <text>Gly616</text>
+      </annotation>
+      <annotation id="675">
+        <infon key="score">0.9986933</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:05Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="25727" length="7"/>
+        <text>CtCBM13</text>
+      </annotation>
+      <annotation id="1025">
+        <infon key="type">bond_interaction</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:02:58Z</infon>
+        <location offset="25770" length="15"/>
+        <text>apolar contacts</text>
+      </annotation>
+      <annotation id="676">
+        <infon key="score">0.9936412</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:41Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="25791" length="6"/>
+        <text>CtCBM6</text>
+      </annotation>
+      <annotation id="677">
+        <infon key="score">0.99960405</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:34:25Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="25799" length="6"/>
+        <text>Pro440</text>
+      </annotation>
+      <annotation id="678">
+        <infon key="score">0.99960774</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:34:28Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="25807" length="6"/>
+        <text>Phe489</text>
+      </annotation>
+      <annotation id="679">
+        <infon key="score">0.9996075</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:34:30Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="25815" length="6"/>
+        <text>Gly491</text>
+      </annotation>
+      <annotation id="680">
+        <infon key="score">0.99959916</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:34:32Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="25827" length="6"/>
+        <text>Ala492</text>
+      </annotation>
+      <annotation id="681">
+        <infon key="score">0.99917793</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:53:05Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="25853" length="6"/>
+        <text>loop 7</text>
+      </annotation>
+      <annotation id="682">
+        <infon key="score">0.98367256</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:37:51Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="25863" length="21"/>
+        <text>completely disordered</text>
+      </annotation>
+      <annotation id="683">
+        <infon key="score">0.9988607</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:37:55Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="25892" length="9"/>
+        <text>truncated</text>
+      </annotation>
+      <annotation id="684">
+        <infon key="score">0.69755924</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:31Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="25916" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="685">
+        <infon key="score">0.9978527</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:02Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="25935" length="5"/>
+        <text>CtGH5</text>
+      </annotation>
+      <annotation id="686">
+        <infon key="score">0.9964631</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:41Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="25945" length="6"/>
+        <text>CtCBM6</text>
+      </annotation>
+      <annotation id="687">
+        <infon key="score">0.99774665</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:05Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="25994" length="7"/>
+        <text>CtCBM13</text>
+      </annotation>
+      <annotation id="688">
+        <infon key="score">0.9942677</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:34:23Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="26037" length="4"/>
+        <text>loop</text>
+      </annotation>
+      <annotation id="689">
+        <infon key="score">0.9990918</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:34:18Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="26063" length="6"/>
+        <text>loop 7</text>
+      </annotation>
+      <annotation id="690">
+        <infon key="score">0.9989008</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:27:57Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="26122" length="11"/>
+        <text>active site</text>
+      </annotation>
+      <annotation id="691">
+        <infon key="score">0.9995603</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:34:43Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="26183" length="6"/>
+        <text>Glu279</text>
+      </annotation>
+      <annotation id="692">
+        <infon key="score">0.9958968</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:34:20Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="26221" length="4"/>
+        <text>loop</text>
+      </annotation>
+      <annotation id="693">
+        <infon key="score">0.5024981</infon>
+        <infon key="type">experimental_method</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:34:46Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="26239" length="7"/>
+        <text>removal</text>
+      </annotation>
+      <annotation id="694">
+        <infon key="score">0.99695325</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:05Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="26250" length="7"/>
+        <text>CtCBM13</text>
+      </annotation>
+      <annotation id="1027">
+        <infon key="type">experimental_method</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:04:06Z</infon>
+        <location offset="26417" length="8"/>
+        <text>deletion</text>
+      </annotation>
+      <annotation id="904">
+        <infon key="type">structure_element</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:05Z</infon>
+        <location offset="26429" length="7"/>
+        <text>CtCBM13</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">RESULTS</infon>
+      <infon key="type">paragraph</infon>
+      <offset>26451</offset>
+      <text>Similar to the interactions between CtCBM6 and CtCBM13, there are extensive hydrophobic interactions between CtCBM13 and CtFn3, resulting in very little flexibility between these modules. As stated above, the absence of CtCBM62 in the structure suggests that the module can adopt multiple positions with respect to the rest of the protein. The CtCBM62, by binding to its ligands (d-Galp and l-Arap) in plant cell walls, may be able to recruit the enzyme onto its target substrate. Xylans are not generally thought to contain such sugars. d-Galp, however, has been detected in xylans in the outer layer of cereal grains and in eucalyptus trees, which are substrates used by CtXyl5A. Thus, CtCBM62 may direct the enzyme to particularly complex xylans containing d-Galp at the non-reducing termini of the side chains, consistent with the open substrate binding cleft of the arabinoxylanase that is optimized to bind highly decorated forms of the hemicellulose. In general CBMs have little influence on enzyme activity against soluble substrates but have a significant impact on glycans within plant cell walls. Thus, the role of CBM62 will likely only be evident against insoluble composite substrates.</text>
+      <annotation id="695">
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+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:41Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="26487" length="6"/>
+        <text>CtCBM6</text>
+      </annotation>
+      <annotation id="696">
+        <infon key="score">0.983107</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:05Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="26498" length="7"/>
+        <text>CtCBM13</text>
+      </annotation>
+      <annotation id="697">
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+        <infon key="type">bond_interaction</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:25:53Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="26527" length="24"/>
+        <text>hydrophobic interactions</text>
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+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:05Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="26560" length="7"/>
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+      <annotation id="699">
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+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:35:31Z</infon>
+        <infon key="identifier">SO:</infon>
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+        <text>CtFn3</text>
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+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:53:10Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="26630" length="7"/>
+        <text>modules</text>
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+      <annotation id="701">
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+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:07:30Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="26660" length="10"/>
+        <text>absence of</text>
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+      <annotation id="702">
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+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:36Z</infon>
+        <infon key="identifier">SO:</infon>
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+        <text>CtCBM62</text>
+      </annotation>
+      <annotation id="703">
+        <infon key="score">0.997883</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:35:39Z</infon>
+        <infon key="identifier">DUMMY:</infon>
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+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:53:13Z</infon>
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+        <infon key="annotator">cleaner0</infon>
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+        <infon key="identifier">DUMMY:</infon>
+        <infon key="annotator">cleaner0</infon>
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+        <infon key="annotator">cleaner0</infon>
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+        <infon key="identifier">CHEBI:</infon>
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+        <infon key="updated_at">2023-09-18T10:24:42Z</infon>
+        <infon key="identifier">DUMMY:</infon>
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+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:32Z</infon>
+        <infon key="identifier">CHEBI:</infon>
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+        <infon key="annotator">cleaner0</infon>
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+        <infon key="identifier">CHEBI:</infon>
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+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:35:15Z</infon>
+        <infon key="identifier">CHEBI:</infon>
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+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:32Z</infon>
+        <infon key="identifier">CHEBI:</infon>
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+        <text>xylans</text>
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+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
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+        <infon key="identifier">DUMMY:</infon>
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+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:35:51Z</infon>
+        <infon key="identifier">DUMMY:</infon>
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+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:31Z</infon>
+        <infon key="identifier">PR:</infon>
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+        <text>CtXyl5A</text>
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+      <annotation id="716">
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+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
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+        <infon key="identifier">SO:</infon>
+        <location offset="27139" length="7"/>
+        <text>CtCBM62</text>
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+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:32Z</infon>
+        <infon key="identifier">CHEBI:</infon>
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+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:35:15Z</infon>
+        <infon key="identifier">CHEBI:</infon>
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+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:06:30Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="27286" length="4"/>
+        <text>open</text>
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+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:36:11Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="27291" length="23"/>
+        <text>substrate binding cleft</text>
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+        <infon key="identifier">MESH:</infon>
+        <location offset="27322" length="15"/>
+        <text>arabinoxylanase</text>
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+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:29:26Z</infon>
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+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:13Z</infon>
+        <infon key="identifier">SO:</infon>
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+        <text>CBMs</text>
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+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:43:24Z</infon>
+        <infon key="identifier">CHEBI:</infon>
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+        <text>glycans</text>
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+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
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+        <infon key="annotator">cleaner0</infon>
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+        <location offset="27577" length="5"/>
+        <text>CBM62</text>
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+    </passage>
+    <passage>
+      <infon key="section_type">RESULTS</infon>
+      <infon key="type">title_4</infon>
+      <offset>27651</offset>
+      <text>Exploring GH5 Subfamily 34</text>
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+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:36:02Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="27661" length="16"/>
+        <text>GH5 Subfamily 34</text>
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+    </passage>
+    <passage>
+      <infon key="section_type">RESULTS</infon>
+      <infon key="type">paragraph</infon>
+      <offset>27678</offset>
+      <text>CtXyl5A is a member of a seven-protein subfamily of GH5, GH5_34. Four of these proteins are distinct, whereas the other three members are essentially identical (derived from different strains of C. thermocellum). To investigate further the substrate specificity within this subfamily, recombinant forms of three members of GH5_34 that were distinct from CtXyl5A were generated. AcGH5 has a similar molecular architecture to CtXyl5A with the exception of an additional carbohydrate esterase family 6 module at the C terminus (Fig. 1). The GH5_34 from Verrucomicrobiae bacterium, VbGH5, contains the GH5-CBM6-CBM13 core structure, but the C-terminal Fn3-CBM62-dockerin modules, present in CtXyl5A, are replaced with a Laminin_3_G domain, which, by analogy to homologous domains in other proteins that have affinity for carbohydrates, may display a glycan binding function. The Verrucomicobiae enzyme also has an N-terminal GH43 subfamily 10 (GH43_10) catalytic module. The fungal GH5_34, GpGH5, unlike the two bacterial homologs, comprises a single GH5 catalytic module lacking all of the other accessory modules (Fig. 1). GpGh5 is particularly interesting as Gonapodya prolifera is the only fungus of the several hundred fungal genomes that encodes a GH5_34 enzyme. In fact there are four potential GH5_34 sequences in the G. prolifera genome, all of which show high sequence homology to Clostridium GH5_34 sequences. G. prolifera and Clostridium occupy similar environments, suggesting that the GpGH5_34 gene was acquired from a Clostridium species, which was followed by duplication of the gene in the fungal genome. The sequence identity of the GH5_34 catalytic modules with CtXyl5A ranged from 55 to 80% (supplemental Fig. S1). All the GH5_34 enzymes were active on the arabinoxylans RAX, WAX, and CX but displayed no activity on BX (Table 1 and Fig. 6) and are thus defined as arabinoxylanases. The limit products generated by CtXyl5A, AcGH5, and GpGH5 comprised a range of oligosaccharides with some high molecular weight material. The oligosaccharides with low degrees of polymerization were absent in the VbGH5 reaction products. However, the enzyme generated a large amount of arabinose, which was not produced by the other arabinoxylanases. Given that GH43_10 is predominantly an arabinofuranosidase subfamily of GH43, the arabinose generated by VbGH5 is likely mediated by the N-terminal catalytic module (see below). Kinetic analysis showed that AcGH5 displayed similar activity to CtXyl5A against both WAX and RAX and was 2-fold less active against CX. When initially measuring the activity of wild type VbGH5 against the different substrates, no clear data could be obtained, regardless of the concentration of enzyme used the reaction appeared to cease after a few minutes. We hypothesized that the N-terminal GH43_10 rapidly removed single arabinose decorations from the arabinoxylans depleting the substrate available to the arabinoxylanase, explaining why this activity was short lived. To test this hypothesis, the conserved catalytic base (Asp45) of the GH43_10 module of VbGH5 was substituted with alanine, which is predicted to inactivate this catalytic module. The D45A mutant did not produce arabinose consistent with the arabinofuranosidase activity displayed by the GH43_10 module in the wild type enzyme (Fig. 6). The kinetics of the GH5_34 arabinoxylanase catalytic module was now measurable, and activities were determined to be between ∼6- and 10-fold lower than that of CtXyl5A. Interestingly, the fungal arabinoxylanase displays the highest activities against WAX and RAX, ∼4- and 6-fold higher, respectively, than CtXyl5A; however, there is very little difference in the activity between the eukaryotic and prokaryotic enzymes against CX. Attempts to express individual modules of a variety of truncations of AcGH5 and VbGH5 were unsuccessful. This may indicate that the individual modules can only fold correctly when incorporated into the full-length enzyme, demonstrating the importance of intermodule interactions to maintain the structural integrity of these enzymes.</text>
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+        <text>CtXyl5A</text>
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+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:36:53Z</infon>
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+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:38:26Z</infon>
+        <infon key="identifier">MESH:</infon>
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+        <text>C. thermocellum</text>
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+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:50:32Z</infon>
+        <infon key="identifier">PR:</infon>
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+        <infon key="annotator">cleaner0</infon>
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+        <infon key="identifier">PR:</infon>
+        <location offset="28102" length="7"/>
+        <text>CtXyl5A</text>
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+        <infon key="identifier">SO:</infon>
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+        <text>carbohydrate esterase family 6 module</text>
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+        <infon key="identifier">MESH:</infon>
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+        <infon key="updated_at">2023-09-18T12:36:54Z</infon>
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+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:37:34Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="28228" length="16"/>
+        <text>Verrucomicrobiae</text>
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+        <infon key="score">0.7465725</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:37:44Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="28245" length="9"/>
+        <text>bacterium</text>
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+        <infon key="score">0.993269</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:49:41Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="28256" length="5"/>
+        <text>VbGH5</text>
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+      <annotation id="1047">
+        <infon key="type">structure_element</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:32:27Z</infon>
+        <location offset="28276" length="14"/>
+        <text>GH5-CBM6-CBM13</text>
+      </annotation>
+      <annotation id="1048">
+        <infon key="type">structure_element</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:32:42Z</infon>
+        <location offset="28326" length="18"/>
+        <text>Fn3-CBM62-dockerin</text>
+      </annotation>
+      <annotation id="737">
+        <infon key="score">0.99669635</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:31Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="28365" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="976">
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+        <text>VbGH5</text>
+      </annotation>
+      <annotation id="978">
+        <infon key="type">protein_type</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:42:40Z</infon>
+        <location offset="30502" length="7"/>
+        <text>GH43_10</text>
+      </annotation>
+      <annotation id="896">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:42Z</infon>
+        <location offset="30533" length="9"/>
+        <text>arabinose</text>
+      </annotation>
+      <annotation id="889">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:42Z</infon>
+        <location offset="30564" length="13"/>
+        <text>arabinoxylans</text>
+      </annotation>
+      <annotation id="890">
+        <infon key="type">protein_type</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:58Z</infon>
+        <location offset="30619" length="15"/>
+        <text>arabinoxylanase</text>
+      </annotation>
+      <annotation id="984">
+        <infon key="type">protein_state</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:44:44Z</infon>
+        <location offset="30711" length="9"/>
+        <text>conserved</text>
+      </annotation>
+      <annotation id="982">
+        <infon key="type">residue_name_number</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:44:04Z</infon>
+        <location offset="30737" length="5"/>
+        <text>Asp45</text>
+      </annotation>
+      <annotation id="979">
+        <infon key="type">structure_element</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:45:12Z</infon>
+        <location offset="30751" length="7"/>
+        <text>GH43_10</text>
+      </annotation>
+      <annotation id="934">
+        <infon key="type">protein</infon>
+        <infon key="identifier">PR:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:49:42Z</infon>
+        <location offset="30769" length="5"/>
+        <text>VbGH5</text>
+      </annotation>
+      <annotation id="985">
+        <infon key="type">experimental_method</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:44:57Z</infon>
+        <location offset="30779" length="16"/>
+        <text>substituted with</text>
+      </annotation>
+      <annotation id="983">
+        <infon key="type">residue_name</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:44:24Z</infon>
+        <location offset="30796" length="7"/>
+        <text>alanine</text>
+      </annotation>
+      <annotation id="901">
+        <infon key="type">structure_element</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:35:55Z</infon>
+        <location offset="30843" length="16"/>
+        <text>catalytic module</text>
+      </annotation>
+      <annotation id="927">
+        <infon key="type">mutant</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:49:23Z</infon>
+        <location offset="30865" length="4"/>
+        <text>D45A</text>
+      </annotation>
+      <annotation id="986">
+        <infon key="type">protein_state</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:45:25Z</infon>
+        <location offset="30870" length="6"/>
+        <text>mutant</text>
+      </annotation>
+      <annotation id="897">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:42Z</infon>
+        <location offset="30893" length="9"/>
+        <text>arabinose</text>
+      </annotation>
+      <annotation id="943">
+        <infon key="type">protein_type</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:54:58Z</infon>
+        <location offset="30923" length="19"/>
+        <text>arabinofuranosidase</text>
+      </annotation>
+      <annotation id="980">
+        <infon key="type">structure_element</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:43:05Z</infon>
+        <location offset="30969" length="7"/>
+        <text>GH43_10</text>
+      </annotation>
+      <annotation id="929">
+        <infon key="type">protein_state</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:49:27Z</infon>
+        <location offset="30991" length="9"/>
+        <text>wild type</text>
+      </annotation>
+      <annotation id="987">
+        <infon key="type">evidence</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:45:51Z</infon>
+        <location offset="31022" length="8"/>
+        <text>kinetics</text>
+      </annotation>
+      <annotation id="968">
+        <infon key="type">protein_type</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:36:54Z</infon>
+        <location offset="31038" length="6"/>
+        <text>GH5_34</text>
+      </annotation>
+      <annotation id="891">
+        <infon key="type">protein_type</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:58Z</infon>
+        <location offset="31045" length="15"/>
+        <text>arabinoxylanase</text>
+      </annotation>
+      <annotation id="902">
+        <infon key="type">structure_element</infon>
+        <infon key="identifier">SO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:35:55Z</infon>
+        <location offset="31061" length="16"/>
+        <text>catalytic module</text>
+      </annotation>
+      <annotation id="886">
+        <infon key="type">protein</infon>
+        <infon key="identifier">PR:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:31Z</infon>
+        <location offset="31178" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="974">
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:38:21Z</infon>
+        <location offset="31206" length="6"/>
+        <text>fungal</text>
+      </annotation>
+      <annotation id="892">
+        <infon key="type">protein_type</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:58Z</infon>
+        <location offset="31213" length="15"/>
+        <text>arabinoxylanase</text>
+      </annotation>
+      <annotation id="915">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:45:24Z</infon>
+        <location offset="31269" length="3"/>
+        <text>WAX</text>
+      </annotation>
+      <annotation id="918">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:45:28Z</infon>
+        <location offset="31277" length="3"/>
+        <text>RAX</text>
+      </annotation>
+      <annotation id="887">
+        <infon key="type">protein</infon>
+        <infon key="identifier">PR:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:32Z</infon>
+        <location offset="31324" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="988">
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:46:09Z</infon>
+        <location offset="31402" length="10"/>
+        <text>eukaryotic</text>
+      </annotation>
+      <annotation id="989">
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:46:19Z</infon>
+        <location offset="31417" length="11"/>
+        <text>prokaryotic</text>
+      </annotation>
+      <annotation id="923">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:46:39Z</infon>
+        <location offset="31445" length="2"/>
+        <text>CX</text>
+      </annotation>
+      <annotation id="938">
+        <infon key="type">protein</infon>
+        <infon key="identifier">PR:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:50:32Z</infon>
+        <location offset="31519" length="5"/>
+        <text>AcGH5</text>
+      </annotation>
+      <annotation id="935">
+        <infon key="type">protein</infon>
+        <infon key="identifier">PR:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:49:42Z</infon>
+        <location offset="31529" length="5"/>
+        <text>VbGH5</text>
+      </annotation>
+      <annotation id="995">
+        <infon key="type">protein_state</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:07:19Z</infon>
+        <location offset="31651" length="11"/>
+        <text>full-length</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="file">zbc0441653440006.jpg</infon>
+      <infon key="id">F6</infon>
+      <infon key="section_type">FIG</infon>
+      <infon key="type">fig_caption</infon>
+      <offset>31787</offset>
+      <text>Products profile generated of GH5_34 enzymes. The enzymes at 1 μm were incubated with the four different xylans at 1% in 50 mm sodium phosphate buffer for 16 h at 37 °C (GpGH5, VbGH5, and AcGH5) or 60 °C. The limit products were separated by TLC. The xylooligosaccharide standards (X) are indicated by their degrees of polymerization.</text>
+      <annotation id="969">
+        <infon key="type">protein_type</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:36:54Z</infon>
+        <location offset="31817" length="6"/>
+        <text>GH5_34</text>
+      </annotation>
+      <annotation id="774">
+        <infon key="score">0.93129015</infon>
+        <infon key="type">experimental_method</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:46:59Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="31858" length="9"/>
+        <text>incubated</text>
+      </annotation>
+      <annotation id="775">
+        <infon key="score">0.99875844</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:32Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="31892" length="6"/>
+        <text>xylans</text>
+      </annotation>
+      <annotation id="776">
+        <infon key="score">0.9989768</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:47:40Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="31957" length="5"/>
+        <text>GpGH5</text>
+      </annotation>
+      <annotation id="777">
+        <infon key="score">0.9987948</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:49:42Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="31964" length="5"/>
+        <text>VbGH5</text>
+      </annotation>
+      <annotation id="778">
+        <infon key="score">0.9988304</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:50:32Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="31975" length="5"/>
+        <text>AcGH5</text>
+      </annotation>
+      <annotation id="779">
+        <infon key="score">0.9960063</infon>
+        <infon key="type">experimental_method</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:47:03Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="32029" length="3"/>
+        <text>TLC</text>
+      </annotation>
+      <annotation id="780">
+        <infon key="score">0.99918824</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:43:43Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="32038" length="19"/>
+        <text>xylooligosaccharide</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">DISCUSS</infon>
+      <infon key="type">title_1</infon>
+      <offset>32125</offset>
+      <text>Discussion</text>
+    </passage>
+    <passage>
+      <infon key="section_type">DISCUSS</infon>
+      <infon key="type">paragraph</infon>
+      <offset>32136</offset>
+      <text>A characteristic feature of enzymes that attack the plant cell wall is their complex molecular architecture. The CBMs in these enzymes generally play a role in substrate targeting and are appended to the catalytic modules through flexible linker sequences. CtXyl5A provides a rare visualization of the structure of multiple modules within a single enzyme. The central feature of these data is the structural role played by two of the CBMs, CtCBM6 and CtCBM13, in maintaining the active conformation of the catalytic module, CtGH5. The crystallographic data described here are supported by biochemical data showing either that these two modules do not bind to glycans (CtCBM13) or that the recognition of the non-reducing end of xylan or cellulose chains (CtCBM6) is unlikely to be biologically significant. It should be emphasized, however, that glycan binding and substrate targeting may only be evident in the full-length enzyme acting on highly complex structures such as the plant cell wall, as observed recently by a CBM46 module in the Bacillus xyloglucanase/mixed linked glucanase BhCel5B.</text>
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+        <infon key="score">0.99862134</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:42Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="32188" length="5"/>
+        <text>plant</text>
+      </annotation>
+      <annotation id="782">
+        <infon key="score">0.9987355</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:13Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="32249" length="4"/>
+        <text>CBMs</text>
+      </annotation>
+      <annotation id="783">
+        <infon key="score">0.99867666</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:53:26Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="32340" length="17"/>
+        <text>catalytic modules</text>
+      </annotation>
+      <annotation id="784">
+        <infon key="score">0.865277</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:53:30Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="32366" length="25"/>
+        <text>flexible linker sequences</text>
+      </annotation>
+      <annotation id="785">
+        <infon key="score">0.5641079</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:32Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="32393" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="786">
+        <infon key="score">0.99627954</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:51:11Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="32438" length="9"/>
+        <text>structure</text>
+      </annotation>
+      <annotation id="787">
+        <infon key="score">0.99776864</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:13Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="32570" length="4"/>
+        <text>CBMs</text>
+      </annotation>
+      <annotation id="788">
+        <infon key="score">0.86189497</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:41Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="32576" length="6"/>
+        <text>CtCBM6</text>
+      </annotation>
+      <annotation id="789">
+        <infon key="score">0.95701545</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:05Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="32587" length="7"/>
+        <text>CtCBM13</text>
+      </annotation>
+      <annotation id="790">
+        <infon key="score">0.99906987</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:38:00Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="32615" length="6"/>
+        <text>active</text>
+      </annotation>
+      <annotation id="791">
+        <infon key="score">0.9981731</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:35:55Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="32642" length="16"/>
+        <text>catalytic module</text>
+      </annotation>
+      <annotation id="792">
+        <infon key="score">0.9962853</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:02Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="32660" length="5"/>
+        <text>CtGH5</text>
+      </annotation>
+      <annotation id="793">
+        <infon key="score">0.99705863</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:51:15Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="32671" length="21"/>
+        <text>crystallographic data</text>
+      </annotation>
+      <annotation id="794">
+        <infon key="score">0.998901</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:43:49Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="32795" length="7"/>
+        <text>glycans</text>
+      </annotation>
+      <annotation id="795">
+        <infon key="score">0.9889486</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:37:05Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="32804" length="7"/>
+        <text>CtCBM13</text>
+      </annotation>
+      <annotation id="796">
+        <infon key="score">0.99855596</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:49Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="32864" length="5"/>
+        <text>xylan</text>
+      </annotation>
+      <annotation id="797">
+        <infon key="score">0.99709713</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:43:53Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="32873" length="9"/>
+        <text>cellulose</text>
+      </annotation>
+      <annotation id="798">
+        <infon key="score">0.9898572</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:41Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="32891" length="6"/>
+        <text>CtCBM6</text>
+      </annotation>
+      <annotation id="799">
+        <infon key="score">0.9853876</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:43:56Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="32982" length="6"/>
+        <text>glycan</text>
+      </annotation>
+      <annotation id="800">
+        <infon key="score">0.99907523</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:07:18Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="33048" length="11"/>
+        <text>full-length</text>
+      </annotation>
+      <annotation id="801">
+        <infon key="score">0.9986217</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:42Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="33115" length="5"/>
+        <text>plant</text>
+      </annotation>
+      <annotation id="802">
+        <infon key="score">0.9963482</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:53:35Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="33158" length="5"/>
+        <text>CBM46</text>
+      </annotation>
+      <annotation id="803">
+        <infon key="score">0.9411532</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:47:23Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="33178" length="8"/>
+        <text>Bacillus</text>
+      </annotation>
+      <annotation id="804">
+        <infon key="score">0.99831474</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:35:26Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="33187" length="13"/>
+        <text>xyloglucanase</text>
+      </annotation>
+      <annotation id="805">
+        <infon key="score">0.9972825</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:35:29Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="33201" length="22"/>
+        <text>mixed linked glucanase</text>
+      </annotation>
+      <annotation id="806">
+        <infon key="score">0.9992636</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:47:30Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="33224" length="7"/>
+        <text>BhCel5B</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">DISCUSS</infon>
+      <infon key="type">paragraph</infon>
+      <offset>33233</offset>
+      <text>CtXyl5A is a member of GH5 that contains 6644 members. These proteins have been subdivided into 51 subfamilies based on sequence similarity. CtXyl5A is a member of subfamily GH5_34. Here we have explored the substrate specificity of the other members of this subfamily. Despite differences in sequence identity all of the homologs were shown to be arabinoxylanases. Consistent with the conserved substrate specificity, all members of GH5_34 contained the specificity determinants Glu68, Tyr92, and Asn139, which make critical interactions with the xylose or arabinose in the −2* subsite, which are 1,3-linked to the xylose positioned in the active site. The presence of a CBM62 in CtXyl5A and AcGH5 suggests that these enzymes target highly complex xylans that contain d-galactose in their side chains. The absence of a “non-structural” CBM in GpGH5 may indicate that this arabinoxylanase is designed to target simpler arabinoxylans present in the endosperm of cereals. Although the characterization of all members of GH5_34 suggests that this subfamily is monospecific, differences in specificity are observed in other subfamilies of GHs including GH43 and GH5. Thus, as new members of GH5_34 are identified from genomic sequence data and subsequently characterized, the specificity of this family may require reinterpretation.</text>
+      <annotation id="807">
+        <infon key="score">0.9979913</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:32Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="33233" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="808">
+        <infon key="score">0.94887006</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:40:58Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="33256" length="3"/>
+        <text>GH5</text>
+      </annotation>
+      <annotation id="809">
+        <infon key="score">0.9977837</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:32Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="33374" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="970">
+        <infon key="type">protein_type</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:36:54Z</infon>
+        <location offset="33407" length="6"/>
+        <text>GH5_34</text>
+      </annotation>
+      <annotation id="810">
+        <infon key="score">0.99929583</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:24Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="33581" length="16"/>
+        <text>arabinoxylanases</text>
+      </annotation>
+      <annotation id="971">
+        <infon key="type">protein_type</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:36:54Z</infon>
+        <location offset="33667" length="6"/>
+        <text>GH5_34</text>
+      </annotation>
+      <annotation id="811">
+        <infon key="score">0.99110305</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:04:24Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="33688" length="24"/>
+        <text>specificity determinants</text>
+      </annotation>
+      <annotation id="812">
+        <infon key="score">0.99954575</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:54Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="33713" length="5"/>
+        <text>Glu68</text>
+      </annotation>
+      <annotation id="813">
+        <infon key="score">0.9995704</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:59Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="33720" length="5"/>
+        <text>Tyr92</text>
+      </annotation>
+      <annotation id="814">
+        <infon key="score">0.99954885</infon>
+        <infon key="type">residue_name_number</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:27:05Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="33731" length="6"/>
+        <text>Asn139</text>
+      </annotation>
+      <annotation id="815">
+        <infon key="score">0.9985304</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:34Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="33781" length="6"/>
+        <text>xylose</text>
+      </annotation>
+      <annotation id="816">
+        <infon key="score">0.99864835</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="33791" length="9"/>
+        <text>arabinose</text>
+      </annotation>
+      <annotation id="817">
+        <infon key="score">0.9986283</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:04:29Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="33808" length="11"/>
+        <text>−2* subsite</text>
+      </annotation>
+      <annotation id="818">
+        <infon key="score">0.9983754</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:34Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="33849" length="6"/>
+        <text>xylose</text>
+      </annotation>
+      <annotation id="819">
+        <infon key="score">0.99908876</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:27:57Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="33874" length="11"/>
+        <text>active site</text>
+      </annotation>
+      <annotation id="820">
+        <infon key="score">0.99881303</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:53:39Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="33905" length="5"/>
+        <text>CBM62</text>
+      </annotation>
+      <annotation id="821">
+        <infon key="score">0.9981012</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:32Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="33914" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+      <annotation id="822">
+        <infon key="score">0.9863192</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:50:32Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="33926" length="5"/>
+        <text>AcGH5</text>
+      </annotation>
+      <annotation id="823">
+        <infon key="score">0.99910295</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:32Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="33982" length="6"/>
+        <text>xylans</text>
+      </annotation>
+      <annotation id="824">
+        <infon key="score">0.9990118</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:44:04Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="34002" length="11"/>
+        <text>d-galactose</text>
+      </annotation>
+      <annotation id="825">
+        <infon key="score">0.70076585</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:07:29Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="34040" length="10"/>
+        <text>absence of</text>
+      </annotation>
+      <annotation id="826">
+        <infon key="score">0.9968041</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:53:44Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="34070" length="3"/>
+        <text>CBM</text>
+      </annotation>
+      <annotation id="827">
+        <infon key="score">0.9990013</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:47:40Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="34077" length="5"/>
+        <text>GpGH5</text>
+      </annotation>
+      <annotation id="828">
+        <infon key="score">0.99921906</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:58Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="34106" length="15"/>
+        <text>arabinoxylanase</text>
+      </annotation>
+      <annotation id="829">
+        <infon key="score">0.9991093</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="34152" length="13"/>
+        <text>arabinoxylans</text>
+      </annotation>
+      <annotation id="830">
+        <infon key="score">0.9977469</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:44:50Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="34194" length="7"/>
+        <text>cereals</text>
+      </annotation>
+      <annotation id="972">
+        <infon key="type">protein_type</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:36:54Z</infon>
+        <location offset="34251" length="6"/>
+        <text>GH5_34</text>
+      </annotation>
+      <annotation id="831">
+        <infon key="score">0.9990747</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:35:33Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="34368" length="3"/>
+        <text>GHs</text>
+      </annotation>
+      <annotation id="832">
+        <infon key="score">0.97536546</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:49:58Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="34382" length="4"/>
+        <text>GH43</text>
+      </annotation>
+      <annotation id="833">
+        <infon key="score">0.993919</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:40:58Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="34391" length="3"/>
+        <text>GH5</text>
+      </annotation>
+      <annotation id="973">
+        <infon key="type">protein_type</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:36:54Z</infon>
+        <location offset="34420" length="6"/>
+        <text>GH5_34</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">DISCUSS</infon>
+      <infon key="type">paragraph</infon>
+      <offset>34568</offset>
+      <text>An intriguing feature of VbGH5 is that the limited products generated by this enzymes are much larger than those produced by the other arabinoxylanases. This suggests that although arabinose decorations contribute to enzyme specificity (VbGH5 is not active on xylans lacking arabinose side chains), the enzyme requires other specificity determinants that occur less frequently in arabinoxylans. This has some resonance with a recently described GH98 xylanase that also exploits specificity determinants that occur infrequently and are only evident in highly complex xylans (e.g. CX).</text>
+      <annotation id="834">
+        <infon key="score">0.9990096</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:49:42Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="34593" length="5"/>
+        <text>VbGH5</text>
+      </annotation>
+      <annotation id="835">
+        <infon key="score">0.9992551</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:24Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="34703" length="16"/>
+        <text>arabinoxylanases</text>
+      </annotation>
+      <annotation id="836">
+        <infon key="score">0.9983157</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="34749" length="9"/>
+        <text>arabinose</text>
+      </annotation>
+      <annotation id="837">
+        <infon key="score">0.999131</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:49:42Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="34805" length="5"/>
+        <text>VbGH5</text>
+      </annotation>
+      <annotation id="838">
+        <infon key="score">0.9985896</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:33Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="34828" length="6"/>
+        <text>xylans</text>
+      </annotation>
+      <annotation id="839">
+        <infon key="score">0.9986557</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="34843" length="9"/>
+        <text>arabinose</text>
+      </annotation>
+      <annotation id="840">
+        <infon key="score">0.9989998</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="34948" length="13"/>
+        <text>arabinoxylans</text>
+      </annotation>
+      <annotation id="841">
+        <infon key="score">0.99906427</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:35:38Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="35013" length="4"/>
+        <text>GH98</text>
+      </annotation>
+      <annotation id="842">
+        <infon key="score">0.9987771</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:35:42Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="35018" length="8"/>
+        <text>xylanase</text>
+      </annotation>
+      <annotation id="843">
+        <infon key="score">0.9987264</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:33Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="35134" length="6"/>
+        <text>xylans</text>
+      </annotation>
+      <annotation id="924">
+        <infon key="type">chemical</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:46:39Z</infon>
+        <location offset="35147" length="2"/>
+        <text>CX</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">DISCUSS</infon>
+      <infon key="type">paragraph</infon>
+      <offset>35152</offset>
+      <text>To conclude, this study provides the molecular basis for the specificity displayed by arabinoxylanases. Substrate specificity is dominated by the pocket that binds single arabinose or xylose side chains. The open xylan binding cleft explains why the enzyme is able to attack highly decorated forms of the hemicellulose. It is also evident that appending additional catalytic modules and CBMs onto the core components of these enzymes generates bespoke arabinoxylanases with activities optimized for specific functions. The specificities of the arabinoxylanases described here are distinct from the classical endo-xylanases and thus have the potential to contribute to the toolbox of biocatalysts required by industries that exploit the plant cell wall as a sustainable substrate.</text>
+      <annotation id="844">
+        <infon key="score">0.9992999</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:24Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="35238" length="16"/>
+        <text>arabinoxylanases</text>
+      </annotation>
+      <annotation id="845">
+        <infon key="score">0.99896705</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:05:33Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="35298" length="6"/>
+        <text>pocket</text>
+      </annotation>
+      <annotation id="846">
+        <infon key="score">0.99837506</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:42Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="35323" length="9"/>
+        <text>arabinose</text>
+      </annotation>
+      <annotation id="847">
+        <infon key="score">0.99813867</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:34Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="35336" length="6"/>
+        <text>xylose</text>
+      </annotation>
+      <annotation id="848">
+        <infon key="score">0.9551583</infon>
+        <infon key="type">protein_state</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:38:17Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="35360" length="4"/>
+        <text>open</text>
+      </annotation>
+      <annotation id="849">
+        <infon key="score">0.99909574</infon>
+        <infon key="type">site</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:49:02Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="35365" length="19"/>
+        <text>xylan binding cleft</text>
+      </annotation>
+      <annotation id="850">
+        <infon key="score">0.9953093</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:29:26Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="35457" length="13"/>
+        <text>hemicellulose</text>
+      </annotation>
+      <annotation id="851">
+        <infon key="score">0.9972641</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:53:50Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="35517" length="17"/>
+        <text>catalytic modules</text>
+      </annotation>
+      <annotation id="852">
+        <infon key="score">0.99897206</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:36:13Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="35539" length="4"/>
+        <text>CBMs</text>
+      </annotation>
+      <annotation id="853">
+        <infon key="score">0.9993069</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:24Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="35604" length="16"/>
+        <text>arabinoxylanases</text>
+      </annotation>
+      <annotation id="854">
+        <infon key="score">0.9992654</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:24Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="35696" length="16"/>
+        <text>arabinoxylanases</text>
+      </annotation>
+      <annotation id="855">
+        <infon key="score">0.9987754</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:35:36Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="35760" length="14"/>
+        <text>endo-xylanases</text>
+      </annotation>
+      <annotation id="856">
+        <infon key="score">0.9984994</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:42Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="35888" length="5"/>
+        <text>plant</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">METHODS</infon>
+      <infon key="type">title_1</infon>
+      <offset>35932</offset>
+      <text>Experimental Procedures</text>
+    </passage>
+    <passage>
+      <infon key="section_type">METHODS</infon>
+      <infon key="type">title_4</infon>
+      <offset>35956</offset>
+      <text>Cloning, Expression, and Purification of Components of CtXyl5A</text>
+    </passage>
+    <passage>
+      <infon key="section_type">METHODS</infon>
+      <infon key="type">paragraph</infon>
+      <offset>36019</offset>
+      <text>All recombinant forms of CtXyl5A used in this study were expressed in the cytoplasm of Escherichia coli because they lacked a signal peptide. DNA encoding CtGH5-CtCBM6 and CtXyl5A-D (CtXyl5A lacking the C-terminal dockerin domain (CtGH5-CtCBM6-CtCBM13-Fn3-CtCBM62)) were described previously. DNA encoding CtGH5-CtCBM6-CtCBM13-Fn3 and CtGH5-CtCBM6-CtCBM13 and mature Acetivibrio cellulolyticus GH5 (AcGH5) were amplified by PCR using plasmid encoding the full-length C. thermocellum arabinoxylanase or A. cellulolyticus genomic DNA as the respective templates. DNA encoding the G. prolifera GH5 (GpGH5) and V. bacterium GH5 (VbGH5) were initially generated by GeneArt® gene synthesis (Thermo Fisher Scientific). DNA encoding VbGH5 lacking the C-terminal cell surface anchoring residues was also amplified by PCR using the synthesized nucleic acid as the template. All the primers used in the PCRs required restriction sites and plasmids used are listed inj supplemental Table S1. All constructs were cloned such that the encoded proteins contain a C-terminal His6 tag. Site-directed mutagenesis was carried out using the PCR-based QuikChange method (Stratagene) deploying the primers listed in supplemental Table S1.</text>
+    </passage>
+    <passage>
+      <infon key="section_type">METHODS</infon>
+      <infon key="type">paragraph</infon>
+      <offset>37237</offset>
+      <text>To express the recombinant proteins, E. coli strain BL21(DE3), harboring appropriate recombinant plasmids, was cultured to mid-exponential phase in Luria broth at 37 °C. Isopropyl β-d-galactopyranoside at 1 mm was then added to induce recombinant gene expression, and the culture incubated for a further 18 h at 16 °C. The recombinant proteins were purified to &gt;90% electrophoretic purity by immobilized metal ion affinity chromatography using TalonTM (Clontech), cobalt-based matrix, and elution with 100 mm imidazole, as described previously. When preparing the selenomethionine derivative of CtXyl5A-D for crystallography, the proteins were expressed in E. coli B834 (DE3), a methionine auxotroph, cultured in medium comprising 1 liter of SelenoMet Medium BaseTM, 50 ml of SelenoMetTM nutrient mix (Molecular Dimensions), and 4 ml of a 10 mg/ml solution of l-selenomethionine. Recombinant gene expression and protein purification were as described above except that all purification buffers were supplemented with 10 mm β-mercaptoethanol.</text>
+    </passage>
+    <passage>
+      <infon key="section_type">METHODS</infon>
+      <infon key="type">title_4</infon>
+      <offset>38285</offset>
+      <text>Enzyme Assays</text>
+    </passage>
+    <passage>
+      <infon key="section_type">METHODS</infon>
+      <infon key="type">paragraph</infon>
+      <offset>38299</offset>
+      <text>CtXyl5A-D and its derivatives were assayed for enzyme activity using the method of Miller to detect the release of reducing sugar. The standard assay was carried out in 50 mm sodium phosphate buffer, pH 7.0, containing 0.1 mg/ml BSA and at substrate concentrations ranging from 1 to 6 mg/ml. The pH and temperature optima were previously determined to be 7 and 60 °C, respectively, for the CtXyl5A-D and its derivatives. The optimum temperature for the other enzymes was found to be 37 °C, and pH optima of 5, 7, and 4 were determined for AcGH5, GpGH5 and VbGH5, respectively. All enzymes were assayed for activity at their individual temperature and pH optimum. A FLUOstar Omega microplate reader (BMG Labtech) was used to measure activity in 96-well plates. Overnight assays to assess end point products were carried out with 6 mg/ml substrate and 1 μm enzyme concentrations. The identification of potential reaction products was also assessed by HPAEC or TLC using methodology described previously.</text>
+    </passage>
+    <passage>
+      <infon key="section_type">METHODS</infon>
+      <infon key="type">title_4</infon>
+      <offset>39304</offset>
+      <text>Oligosaccharide Analysis</text>
+    </passage>
+    <passage>
+      <infon key="section_type">METHODS</infon>
+      <infon key="type">paragraph</infon>
+      <offset>39329</offset>
+      <text>Approximately 5 g of CX or WAX were digested to completion (no further increase in reducing sugar and change in the HPAEC product profile) with 3 μm of CtXyl5A-D at 60 °C for 48 h. The oligosaccharide products were purified by size exclusion chromatography using a Bio-Gel P2 column as described previously. The structures of the oligosaccharides were analyzed by positive ion-mode infusion/offline electrospray ionization (ESI)-MS following either dilution with 30% acetonitrile or via desalting as described previously </text>
+    </passage>
+    <passage>
+      <infon key="section_type">METHODS</infon>
+      <infon key="type">title_4</infon>
+      <offset>39853</offset>
+      <text>Crystallography</text>
+    </passage>
+    <passage>
+      <infon key="section_type">METHODS</infon>
+      <infon key="type">paragraph</infon>
+      <offset>39869</offset>
+      <text>Purified SeMet CtXyl5A-D was concentrated and stored in 5 mm DTT, 2 mm CaCl2. Crystals of seleno-l-methionine-containing protein were obtained by hanging drop vapor diffusion in 40% (v/v) 2-methyl-2,4-pentandiol. The data were collected on Beamlines ID14-1 and ID14-4 at the European Synchrotron Radiation Facility (Grenoble, France) to a resolution of 2.64 Å. The data were processed using the programs iMOSFLM and SCALA from the CCP4 suite (Collaborative Computational Project, Number 4, 1994). The crystal belongs to the orthorhombic space group (P21212). The structure was solved by molecular replacement using independently solved structures of some of the modules of the CtXyl5A: CtGH5-CBM6 (PDB code 2y8k), Fn3 (PDB code 3mpc), and CtCBM62 (PDB codes 2y8m, 2yfz, and 2y9s) using PHASER. The CtCBM13 domain was built de novo. BUCCANEER and PHENIX were initially used for auto building. The structure was completed by iterative cycles of manual rebuilding in COOT in tandem with refinement with RefMac5. The final values for Rwork and Rfree) were 23.73 and 27.80%) using TLS and restraining refinement to amino acid residues 36–373 representing the CtGH5 module, 374–516 for the CtCBM6, 517–652 for CtCBM13, and 653–742 for CtFn3. Stereochemistry was assessed with COOT and PDBSUM (with 677 residues (96%) in preferred, 22 in allowed regions (3%), and 6 outliers (1%) in the Ramachandran plot).</text>
+    </passage>
+    <passage>
+      <infon key="section_type">METHODS</infon>
+      <infon key="type">paragraph</infon>
+      <offset>41279</offset>
+      <text>To obtain structures of CtGH5-CBM6 in complex with ligand the protein was crystallized using the sitting drop vapor phase diffusion method with an equal volume (100 nl) of protein and reservoir solution (unless otherwise stated), using the robotic nanodrop dispensing systems (mosquitoR LCP; TTPLabTech). Crystals of the protein (10 mg/ml) co-crystallized with arabinose (300 mm) were obtained in 1 m ammonium sulfate, 0.1 m Bis-Tris, pH 5.5, and 1% PEG 3350. Crystals with xylose (300 mm) grew in 100 mm sodium/potassium phosphate, 100 mm MES, pH 6.5, and 2 m sodium chloride. To obtain crystals of the arabinoxylanase in complex with an oligosaccharide, the nucleophile mutant E279S was used and mixed with a range of arabinoxylooligosaccharides that was generated by digestion of WAX with CtGH5-CBM6 (see above) and thereafter by 100 nm of the Cellvibrio japonicus GH43 exo-1,4-β-xylosidase. Only the inclusion of the largest purified oligosaccharide generated crystals of the arabinoxylanase. Crystals of CtGH5E279S-CBM6 were obtained by mixing an equal volume (100 nl) of the protein (11 mg/ml)/oligosaccharide (10 mm) solution and mother liquor solution consisting of 100 mm Tris-Bicine, pH 8.5, 12.5% (w/v) polyethylene glycol with an average molecular mass of 1,000 Da, 12.5% (w/v) polyethylene glycol with an average molecular mass of 3,350 Da and 12.5% (R,S)-2-methyl-2,4-pentanediol (racemic). Crystallographic data were collected on Beamlines IO2, IO4-1, and I24 at the DIAMOND Light Source (Harwell, UK). The data were processed using XDS The crystal structures were solved by molecular replacement using MolRep with CtGH5-CtCBM6 (PDB code 5AK1) as the search model. The refinement was done in RefMac5, and COOT was used for model (re)building. The final model were validated using Molprobity. The data collection and refinement statistics are listed in Table 2.</text>
+    </passage>
+    <passage>
+      <infon key="file">T2.xml</infon>
+      <infon key="id">T2</infon>
+      <infon key="section_type">TABLE</infon>
+      <infon key="type">table_caption</infon>
+      <offset>43158</offset>
+      <text>Data collection and refinement statistics</text>
+      <annotation id="990">
+        <infon key="type">evidence</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:51:14Z</infon>
+        <location offset="43158" length="41"/>
+        <text>Data collection and refinement statistics</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="file">T2.xml</infon>
+      <infon key="id">T2</infon>
+      <infon key="section_type">TABLE</infon>
+      <infon key="type">table_caption</infon>
+      <offset>43200</offset>
+      <text>The values in parentheses are for highest resolution shell.</text>
+    </passage>
+    <passage>
+      <infon key="file">T2.xml</infon>
+      <infon key="id">T2</infon>
+      <infon key="section_type">TABLE</infon>
+      <infon key="type">table</infon>
+      <infon key="xml">&lt;?xml version="1.0" encoding="UTF-8"?&gt;
+&lt;table xmlns:xlink="http://www.w3.org/1999/xlink" frame="hsides" rules="groups"&gt;&lt;thead valign="bottom"&gt;&lt;tr&gt;&lt;th rowspan="1" colspan="1"/&gt;&lt;th align="center" rowspan="1" colspan="1"&gt;CtXyl5A&lt;sub&gt;-D&lt;/sub&gt;&lt;/th&gt;&lt;th align="center" rowspan="1" colspan="1"&gt;GH5-CBM6-&lt;italic&gt;Arap&lt;/italic&gt;&lt;/th&gt;&lt;th align="center" rowspan="1" colspan="1"&gt;GH5-CBM6-&lt;italic&gt;Xylp&lt;/italic&gt;&lt;/th&gt;&lt;th align="center" rowspan="1" colspan="1"&gt;GH5-CBM6- (&lt;italic&gt;Araf&lt;/italic&gt;-Xyl&lt;italic&gt;p&lt;/italic&gt;&lt;sub&gt;4&lt;/sub&gt;)&lt;/th&gt;&lt;/tr&gt;&lt;/thead&gt;&lt;tbody valign="top"&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;bold&gt;Data collection&lt;/bold&gt;&lt;/td&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;    Source&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;ESRF-ID14-1&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;Diamond I04–1&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;Diamond I24&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;Diamond I02&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;    Wavelength (Å)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;0.9334&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;0.9173&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;0.9772&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;0.9791&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;    Space group&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;P2&lt;sub&gt;1&lt;/sub&gt;2&lt;sub&gt;1&lt;/sub&gt;2&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;P2&lt;sub&gt;1&lt;/sub&gt;2&lt;sub&gt;1&lt;/sub&gt;2&lt;sub&gt;1&lt;/sub&gt;&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;P2&lt;sub&gt;1&lt;/sub&gt;2&lt;sub&gt;1&lt;/sub&gt;2&lt;sub&gt;1&lt;/sub&gt;&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;P2&lt;sub&gt;1&lt;/sub&gt;2&lt;sub&gt;1&lt;/sub&gt;2&lt;sub&gt;1&lt;/sub&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;    Cell dimensions&lt;/td&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;        &lt;italic&gt;a&lt;/italic&gt;, &lt;italic&gt;b&lt;/italic&gt;, &lt;italic&gt;c&lt;/italic&gt; (Å)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;147.4, 191.7, 50.7&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;67.1, 72.4, 109.1&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;67.9, 72.5, 109.5&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;76.3, 123.2, 125.4&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;        α, β, γ (°)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;90, 90, 90&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;90, 90, 90&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;90, 90, 90&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;90, 90, 90&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;    No. of measured reflections&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;244,475 (29,324)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;224,842 (11,281)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;152,004 (4,996)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;463,237 (23,068)&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;    No. of independent reflections&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;42246 (5,920)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;63,523 (3,175)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;42,716 (2,334)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;140,288 (6,879)&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;    Resolution (Å)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;50.70–2.64 (2.78–2.64)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;44.85–1.65 (1.68–1.65)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;45.16–1.90 (1.94–1.90)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;48.43–1.65 (1.68–1.65)&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;    &lt;italic&gt;R&lt;/italic&gt;&lt;sub&gt;merge&lt;/sub&gt; (%)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;16.5 (69.5)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;6.7 (65.1)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;2.8 (8.4)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;5.7 (74.9)&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;    CC&lt;sub&gt;1/2&lt;/sub&gt;&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;0.985 (0.478)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;0.998 (0.594)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;0.999 (0.982)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;0.998 (0.484)&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;    &lt;italic&gt;I&lt;/italic&gt;/σ&lt;italic&gt;I&lt;/italic&gt;&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;8.0 (2.0)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;13 (1.6)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;26.6 (8.0)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;11.2 (1.6)&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;    Completeness (%)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;98.5 (96.4)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;98.5 (99.4)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;98.6 (85.0)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;98.8 (99.4)&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;    Redundancy&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;5.8 (5.0)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;3.5 (3.6)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;3.6 (2.1)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;3.3 (3.4)&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td colspan="5" rowspan="1"&gt;&lt;hr/&gt;&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;bold&gt;Refinement&lt;/bold&gt;&lt;/td&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;    &lt;italic&gt;R&lt;/italic&gt;&lt;sub&gt;work&lt;/sub&gt;/&lt;italic&gt;R&lt;/italic&gt;&lt;sub&gt;free&lt;/sub&gt;&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;23.7/27.8&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;12.2/17.0&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;12.9/16.1&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;14.5/19.9&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;    No. atoms&lt;/td&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;        Protein&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;5446&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;3790&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;3729&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;7333&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;        Ligand&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;19&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;20&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;20&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;92&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;        Water&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;227&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;579&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;601&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;923&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;    B-factors&lt;/td&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;        Protein&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;41.6&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;17.8&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;15.8&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;21.0&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;        Ligand&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;65.0&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;19.4&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;24.2&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;39.5&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;        Water&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;35.4&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;38.5&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;32.2&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;37.6&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;    R.m.s deviations&lt;/td&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;td rowspan="1" colspan="1"/&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;        Bond lengths (Å)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;0.008&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;0.015&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;0.012&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;0.012&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;        Bond angles (°)&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;1.233&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;1.502&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;1.624&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;1.554&lt;/td&gt;&lt;/tr&gt;&lt;tr&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;    Protein Data Bank code&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;ext-link ext-link-type="pdb" xlink:href="5G56"&gt;5G56&lt;/ext-link&gt;&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;ext-link ext-link-type="pdb" xlink:href="5LA0"&gt;5LA0&lt;/ext-link&gt;&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;ext-link ext-link-type="pdb" xlink:href="5LA1"&gt;5LA1&lt;/ext-link&gt;&lt;/td&gt;&lt;td align="left" rowspan="1" colspan="1"&gt;&lt;ext-link ext-link-type="pdb" xlink:href="2LA2"&gt;2LA2&lt;/ext-link&gt;&lt;/td&gt;&lt;/tr&gt;&lt;/tbody&gt;&lt;/table&gt;
+</infon>
+      <offset>43260</offset>
+      <text>	CtXyl5A-D	GH5-CBM6-Arap	GH5-CBM6-Xylp	GH5-CBM6- (Araf-Xylp4)	 	Data collection					 	    Source	ESRF-ID14-1	Diamond I04–1	Diamond I24	Diamond I02	 	    Wavelength (Å)	0.9334	0.9173	0.9772	0.9791	 	    Space group	P21212	P212121	P212121	P212121	 	    Cell dimensions					 	        a, b, c (Å)	147.4, 191.7, 50.7	67.1, 72.4, 109.1	67.9, 72.5, 109.5	76.3, 123.2, 125.4	 	        α, β, γ (°)	90, 90, 90	90, 90, 90	90, 90, 90	90, 90, 90	 	    No. of measured reflections	244,475 (29,324)	224,842 (11,281)	152,004 (4,996)	463,237 (23,068)	 	    No. of independent reflections	42246 (5,920)	63,523 (3,175)	42,716 (2,334)	140,288 (6,879)	 	    Resolution (Å)	50.70–2.64 (2.78–2.64)	44.85–1.65 (1.68–1.65)	45.16–1.90 (1.94–1.90)	48.43–1.65 (1.68–1.65)	 	    Rmerge (%)	16.5 (69.5)	6.7 (65.1)	2.8 (8.4)	5.7 (74.9)	 	    CC1/2	0.985 (0.478)	0.998 (0.594)	0.999 (0.982)	0.998 (0.484)	 	    I/σI	8.0 (2.0)	13 (1.6)	26.6 (8.0)	11.2 (1.6)	 	    Completeness (%)	98.5 (96.4)	98.5 (99.4)	98.6 (85.0)	98.8 (99.4)	 	    Redundancy	5.8 (5.0)	3.5 (3.6)	3.6 (2.1)	3.3 (3.4)	 		 	Refinement					 	    Rwork/Rfree	23.7/27.8	12.2/17.0	12.9/16.1	14.5/19.9	 	    No. atoms					 	        Protein	5446	3790	3729	7333	 	        Ligand	19	20	20	92	 	        Water	227	579	601	923	 	    B-factors					 	        Protein	41.6	17.8	15.8	21.0	 	        Ligand	65.0	19.4	24.2	39.5	 	        Water	35.4	38.5	32.2	37.6	 	    R.m.s deviations					 	        Bond lengths (Å)	0.008	0.015	0.012	0.012	 	        Bond angles (°)	1.233	1.502	1.624	1.554	 	    Protein Data Bank code	5G56	5LA0	5LA1	2LA2	 	</text>
+      <annotation id="954">
+        <infon key="type">mutant</infon>
+        <infon key="identifier">MESH:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:27:43Z</infon>
+        <location offset="43261" length="9"/>
+        <text>CtXyl5A-D</text>
+      </annotation>
+      <annotation id="857">
+        <infon key="score">0.9927343</infon>
+        <infon key="type">complex_assembly</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:52:03Z</infon>
+        <infon key="identifier">GO:</infon>
+        <location offset="43271" length="13"/>
+        <text>GH5-CBM6-Arap</text>
+      </annotation>
+      <annotation id="858">
+        <infon key="score">0.99599856</infon>
+        <infon key="type">complex_assembly</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:52:14Z</infon>
+        <infon key="identifier">GO:</infon>
+        <location offset="43285" length="13"/>
+        <text>GH5-CBM6-Xylp</text>
+      </annotation>
+      <annotation id="991">
+        <infon key="type">complex_assembly</infon>
+        <infon key="identifier">GO:</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:52:48Z</infon>
+        <location offset="43299" length="22"/>
+        <text>GH5-CBM6- (Araf-Xylp4)</text>
+      </annotation>
+      <annotation id="859">
+        <infon key="score">0.91044104</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:52:52Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="44339" length="5"/>
+        <text>Rwork</text>
+      </annotation>
+      <annotation id="860">
+        <infon key="score">0.8382509</infon>
+        <infon key="type">evidence</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T12:52:54Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="44345" length="5"/>
+        <text>Rfree</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">AUTH_CONT</infon>
+      <infon key="type">title_1</infon>
+      <offset>45145</offset>
+      <text>Author Contributions</text>
+    </passage>
+    <passage>
+      <infon key="section_type">AUTH_CONT</infon>
+      <infon key="type">paragraph</infon>
+      <offset>45166</offset>
+      <text>A. L. obtained crystals of the GH5-CBM6 complex. L. I. C. analyzed the biochemistry of GH5 subfamilies. J. L. A. B. obtained crystals of CtXyl5A-D. A. J. analyzed the biochemistry of GH5-CBM6 and obtained crystals of GH5-CBM6. A. R. analyzed the biochemistry of GH5-CBM6 products. J. G. performed mass spectrometry. M. P. Y. provided the substrate. B. H. performed analysis of GH5 sequences. C. M. G. A. F. designed the experiments. H. J. G. designed the experiments, analyzed data, and contributed to writing the paper. S. N. solved the structure of CtXyl5A-D and contributed to writing the paper. A. B. used crystallography to solve GH5-CBM6 structures. F. C. analyzed the biochemistry of GH5-CBM6 mutants, obtained crystals of GH5-CBM6, and contributed to writing the paper.</text>
+    </passage>
+    <passage>
+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">title_1</infon>
+      <offset>45944</offset>
+      <text>Supplementary Material</text>
+    </passage>
+    <passage>
+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">footnote</infon>
+      <offset>45967</offset>
+      <text>This work was supported in part by European Research Council Grant 322820 (to H. J. G. and B. H.), Biotechnology and Biological Research Council Grants BB/K020358/1 and BB/K001949/1 (to H. J. G.), Wellcome Trust Grant RES/0120/7613 (to H. J. G.), Agence Nationale de la Recherche Grant ANR 12-BIME-0006-01 (to B. H.), and Fundação para a Ciência e Tecnologia Grants PTDC/BIAPRO/103980/2008 and PTDC/BIAMIC/5947/2014 (to C. M. G. A. F.). The authors declare that they have no conflicts of interest with the contents of this article.</text>
+    </passage>
+    <passage>
+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">footnote</infon>
+      <offset>46502</offset>
+      <text>This article contains supplemental Table S1 and Fig. S1.</text>
+    </passage>
+    <passage>
+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">footnote</infon>
+      <offset>46559</offset>
+      <text>GH</text>
+      <annotation id="861">
+        <infon key="score">0.9930426</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:31:28Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="46559" length="2"/>
+        <text>GH</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">footnote</infon>
+      <offset>46562</offset>
+      <text>glycoside hydrolase</text>
+      <annotation id="862">
+        <infon key="score">0.9983388</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:31:20Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="46562" length="19"/>
+        <text>glycoside hydrolase</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">footnote</infon>
+      <offset>46582</offset>
+      <text>CtXyl5A</text>
+      <annotation id="863">
+        <infon key="score">0.9968766</infon>
+        <infon key="type">protein</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:32Z</infon>
+        <infon key="identifier">PR:</infon>
+        <location offset="46582" length="7"/>
+        <text>CtXyl5A</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">footnote</infon>
+      <offset>46590</offset>
+      <text>C. thermocellum arabinoxylanase</text>
+      <annotation id="864">
+        <infon key="score">0.9984484</infon>
+        <infon key="type">species</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:38:26Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="46590" length="15"/>
+        <text>C. thermocellum</text>
+      </annotation>
+      <annotation id="865">
+        <infon key="score">0.998863</infon>
+        <infon key="type">protein_type</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:25:58Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="46606" length="15"/>
+        <text>arabinoxylanase</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">footnote</infon>
+      <offset>46622</offset>
+      <text>CBM</text>
+      <annotation id="866">
+        <infon key="score">0.99871993</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:53:56Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="46622" length="3"/>
+        <text>CBM</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">footnote</infon>
+      <offset>46626</offset>
+      <text>non-catalytic carbohydrate binding module</text>
+      <annotation id="867">
+        <infon key="score">0.82269233</infon>
+        <infon key="type">structure_element</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:26:26Z</infon>
+        <infon key="identifier">SO:</infon>
+        <location offset="46626" length="41"/>
+        <text>non-catalytic carbohydrate binding module</text>
+      </annotation>
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+    <passage>
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+        <text>Fn</text>
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+    <passage>
+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">footnote</infon>
+      <offset>46671</offset>
+      <text>fibronectin</text>
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+        <text>fibronectin</text>
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+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">footnote</infon>
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+        <infon key="identifier">CHEBI:</infon>
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+    <passage>
+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">footnote</infon>
+      <offset>46687</offset>
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+        <infon key="type">taxonomy_domain</infon>
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+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">footnote</infon>
+      <offset>46710</offset>
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+        <infon key="identifier">CHEBI:</infon>
+        <location offset="46714" length="12"/>
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+      <infon key="section_type">SUPPL</infon>
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+        <infon key="identifier">CHEBI:</infon>
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+        <text>CX</text>
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+    <passage>
+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">footnote</infon>
+      <offset>46730</offset>
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+        <infon key="score">0.6373213</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
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+        <infon key="identifier">DUMMY:</infon>
+        <location offset="46730" length="4"/>
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+        <infon key="score">0.8507954</infon>
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+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:49Z</infon>
+        <infon key="identifier">CHEBI:</infon>
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+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">footnote</infon>
+      <offset>46746</offset>
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+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:58:50Z</infon>
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+        <location offset="46746" length="5"/>
+        <text>HPAEC</text>
+      </annotation>
+    </passage>
+    <passage>
+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">footnote</infon>
+      <offset>46752</offset>
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+      <annotation id="880">
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+        <infon key="annotator">cleaner0</infon>
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+        <infon key="identifier">MESH:</infon>
+        <location offset="46752" length="46"/>
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+    </passage>
+    <passage>
+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">footnote</infon>
+      <offset>46799</offset>
+      <text>PDB</text>
+    </passage>
+    <passage>
+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">footnote</infon>
+      <offset>46803</offset>
+      <text>Protein Data Bank</text>
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+    <passage>
+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">footnote</infon>
+      <offset>46821</offset>
+      <text>BX</text>
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+    <passage>
+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">footnote</infon>
+      <offset>46824</offset>
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+        <infon key="score">0.96442974</infon>
+        <infon key="type">taxonomy_domain</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T13:44:55Z</infon>
+        <infon key="identifier">DUMMY:</infon>
+        <location offset="46824" length="9"/>
+        <text>birchwood</text>
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+      <annotation id="882">
+        <infon key="score">0.99584645</infon>
+        <infon key="type">chemical</infon>
+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T10:24:49Z</infon>
+        <infon key="identifier">CHEBI:</infon>
+        <location offset="46834" length="5"/>
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+    </passage>
+    <passage>
+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">footnote</infon>
+      <offset>46840</offset>
+      <text>ESI</text>
+    </passage>
+    <passage>
+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">footnote</infon>
+      <offset>46844</offset>
+      <text>electrospray ionization.</text>
+      <annotation id="883">
+        <infon key="score">0.99849916</infon>
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+        <infon key="annotator">cleaner0</infon>
+        <infon key="updated_at">2023-09-18T14:06:20Z</infon>
+        <infon key="identifier">MESH:</infon>
+        <location offset="46844" length="23"/>
+        <text>electrospray ionization</text>
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+    </passage>
+    <passage>
+      <infon key="section_type">SUPPL</infon>
+      <infon key="type">footnote</infon>
+      <offset>46869</offset>
+      <text>The abbreviations used are: </text>
+    </passage>
+    <passage>
+      <infon key="section_type">REF</infon>
+      <infon key="type">title</infon>
+      <offset>46898</offset>
+      <text>References</text>
+    </passage>
+    <passage>
+      <infon key="fpage">444</infon>
+      <infon key="lpage">455</infon>
+      <infon key="name_0">surname:Gilbert;given-names:H. J.</infon>
+      <infon key="pub-id_pmid">20406913</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Plant Physiol</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">153</infon>
+      <infon key="year">2010</infon>
+      <offset>46909</offset>
+      <text>The biochemistry and structural biology of plant cell wall deconstruction</text>
+    </passage>
+    <passage>
+      <infon key="fpage">316</infon>
+      <infon key="lpage">317</infon>
+      <infon key="name_0">surname:Himmel;given-names:M. E.</infon>
+      <infon key="name_1">surname:Bayer;given-names:E. A.</infon>
+      <infon key="pub-id_pmid">19523813</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Curr. Opin. Biotechnol</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">20</infon>
+      <infon key="year">2009</infon>
+      <offset>46983</offset>
+      <text>Lignocellulose conversion to biofuels: current challenges, global perspectives</text>
+    </passage>
+    <passage>
+      <infon key="name_0">surname:Brett;given-names:C. W.</infon>
+      <infon key="name_1">surname:K.</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Physiology and biochemistry of plant cell walls: Topics in Plant Functional Biology</infon>
+      <infon key="type">ref</infon>
+      <infon key="year">1996</infon>
+      <offset>47062</offset>
+    </passage>
+    <passage>
+      <infon key="fpage">1</infon>
+      <infon key="lpage">67</infon>
+      <infon key="name_0">surname:Ebringerova;given-names:A.</infon>
+      <infon key="name_1">surname:Hromadkova;given-names:Z.</infon>
+      <infon key="name_2">surname:Heinze;given-names:T.</infon>
+      <infon key="name_3">surname:Hienzy;given-names:T.</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Polysaccharide I</infon>
+      <infon key="type">ref</infon>
+      <infon key="year">2005</infon>
+      <offset>47063</offset>
+      <text>Structure, characterization and use</text>
+    </passage>
+    <passage>
+      <infon key="fpage">6141</infon>
+      <infon key="lpage">6148</infon>
+      <infon key="name_0">surname:Agger;given-names:J.</infon>
+      <infon key="name_1">surname:Viksø-Nielsen;given-names:A.</infon>
+      <infon key="name_2">surname:Meyer;given-names:A. S.</infon>
+      <infon key="pub-id_pmid">20411987</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">J. Agric. Food Chem</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">58</infon>
+      <infon key="year">2010</infon>
+      <offset>47099</offset>
+      <text>Enzymatic xylose release from pretreated corn bran arabinoxylan: differential effects of deacetylation and deferuloylation on insoluble and soluble substrate fractions</text>
+    </passage>
+    <passage>
+      <infon key="fpage">D490</infon>
+      <infon key="lpage">D495</infon>
+      <infon key="name_0">surname:Lombard;given-names:V.</infon>
+      <infon key="name_1">surname:Golaconda Ramulu;given-names:H.</infon>
+      <infon key="name_2">surname:Drula;given-names:E.</infon>
+      <infon key="name_3">surname:Coutinho;given-names:P. M.</infon>
+      <infon key="name_4">surname:Henrissat;given-names:B.</infon>
+      <infon key="pub-id_pmid">24270786</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Nucleic. Acids Res</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">42</infon>
+      <infon key="year">2014</infon>
+      <offset>47267</offset>
+      <text>The carbohydrate-active enzymes database (CAZy) in 2013</text>
+    </passage>
+    <passage>
+      <infon key="fpage">338</infon>
+      <infon key="lpage">348</infon>
+      <infon key="name_0">surname:Gilbert;given-names:H. J.</infon>
+      <infon key="name_1">surname:Stålbrand;given-names:H.</infon>
+      <infon key="name_2">surname:Brumer;given-names:H.</infon>
+      <infon key="pub-id_pmid">18430603</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Curr. Opin. Plant Biol</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">11</infon>
+      <infon key="year">2008</infon>
+      <offset>47323</offset>
+      <text>How the walls come crumbling down: recent structural biochemistry of plant polysaccharide degradation</text>
+    </passage>
+    <passage>
+      <infon key="fpage">9597</infon>
+      <infon key="lpage">9605</infon>
+      <infon key="name_0">surname:Pell;given-names:G.</infon>
+      <infon key="name_1">surname:Taylor;given-names:E. J.</infon>
+      <infon key="name_2">surname:Gloster;given-names:T. M.</infon>
+      <infon key="name_3">surname:Turkenburg;given-names:J. P.</infon>
+      <infon key="name_4">surname:Fontes;given-names:C. M.</infon>
+      <infon key="name_5">surname:Ferreira;given-names:L. M.</infon>
+      <infon key="name_6">surname:Nagy;given-names:T.</infon>
+      <infon key="name_7">surname:Clark;given-names:S. J.</infon>
+      <infon key="name_8">surname:Davies;given-names:G. J.</infon>
+      <infon key="name_9">surname:Gilbert;given-names:H. J.</infon>
+      <infon key="pub-id_pmid">14668328</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">J. Biol. Chem</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">279</infon>
+      <infon key="year">2004</infon>
+      <offset>47425</offset>
+      <text>The mechanisms by which family 10 glycoside hydrolases bind decorated substrates</text>
+    </passage>
+    <passage>
+      <infon key="fpage">1666</infon>
+      <infon key="lpage">1677</infon>
+      <infon key="name_0">surname:Vrsanská;given-names:M.</infon>
+      <infon key="name_1">surname:Kolenová;given-names:K.</infon>
+      <infon key="name_2">surname:Puchart;given-names:V.</infon>
+      <infon key="name_3">surname:Biely;given-names:P.</infon>
+      <infon key="pub-id_pmid">17381510</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">FEBS J</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">274</infon>
+      <infon key="year">2007</infon>
+      <offset>47506</offset>
+      <text>Mode of action of glycoside hydrolase family 5 glucuronoxylan xylanohydrolase from Erwinia chrysanthemi</text>
+    </passage>
+    <passage>
+      <infon key="fpage">557</infon>
+      <infon key="lpage">559</infon>
+      <infon key="name_0">surname:Davies;given-names:G. J.</infon>
+      <infon key="name_1">surname:Wilson;given-names:K. S.</infon>
+      <infon key="name_2">surname:Henrissat;given-names:B.</infon>
+      <infon key="pub-id_pmid">9020895</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Biochem. J</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">321</infon>
+      <infon key="year">1997</infon>
+      <offset>47610</offset>
+      <text>Nomenclature for sugar-binding subsites in glycosyl hydrolases</text>
+    </passage>
+    <passage>
+      <infon key="fpage">22510</infon>
+      <infon key="lpage">22520</infon>
+      <infon key="name_0">surname:Correia;given-names:M. A.</infon>
+      <infon key="name_1">surname:Mazumder;given-names:K.</infon>
+      <infon key="name_2">surname:Brás;given-names:J. L.</infon>
+      <infon key="name_3">surname:Firbank;given-names:S. J.</infon>
+      <infon key="name_4">surname:Zhu;given-names:Y.</infon>
+      <infon key="name_5">surname:Lewis;given-names:R. J.</infon>
+      <infon key="name_6">surname:York;given-names:W. S.</infon>
+      <infon key="name_7">surname:Fontes;given-names:C. M.</infon>
+      <infon key="name_8">surname:Gilbert;given-names:H. J.</infon>
+      <infon key="pub-id_pmid">21378160</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">J. Biol. Chem</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">286</infon>
+      <infon key="year">2011</infon>
+      <offset>47673</offset>
+      <text>Structure and function of an arabinoxylan-specific xylanase</text>
+    </passage>
+    <passage>
+      <infon key="fpage">878</infon>
+      <infon key="lpage">880</infon>
+      <infon key="name_0">surname:Alahuhta;given-names:M.</infon>
+      <infon key="name_1">surname:Xu;given-names:Q.</infon>
+      <infon key="name_2">surname:Brunecky;given-names:R.</infon>
+      <infon key="name_3">surname:Adney;given-names:W. S.</infon>
+      <infon key="name_4">surname:Ding;given-names:S. Y.</infon>
+      <infon key="name_5">surname:Himmel;given-names:M. E.</infon>
+      <infon key="name_6">surname:Lunin;given-names:V. V.</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">66</infon>
+      <infon key="year">2010</infon>
+      <offset>47733</offset>
+      <text>Structure of a fibronectin type III-like module from Clostridium thermocellum</text>
+    </passage>
+    <passage>
+      <infon key="fpage">521</infon>
+      <infon key="lpage">554</infon>
+      <infon key="name_0">surname:Bayer;given-names:E. A.</infon>
+      <infon key="name_1">surname:Belaich;given-names:J. P.</infon>
+      <infon key="name_2">surname:Shoham;given-names:Y.</infon>
+      <infon key="name_3">surname:Lamed;given-names:R.</infon>
+      <infon key="pub-id_pmid">15487947</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Annu. Rev. Microbiol</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">58</infon>
+      <infon key="year">2004</infon>
+      <offset>47811</offset>
+      <text>The cellulosomes: Multienzyme machines for degradation of plant cell wall polysaccharides</text>
+    </passage>
+    <passage>
+      <infon key="fpage">655</infon>
+      <infon key="lpage">681</infon>
+      <infon key="name_0">surname:Fontes;given-names:C. M.</infon>
+      <infon key="name_1">surname:Gilbert;given-names:H. J.</infon>
+      <infon key="pub-id_pmid">20373916</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Annu. Rev. Biochem</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">79</infon>
+      <infon key="year">2010</infon>
+      <offset>47901</offset>
+      <text>Cellulosomes: highly efficient nanomachines designed to deconstruct plant cell wall complex carbohydrates</text>
+    </passage>
+    <passage>
+      <infon key="fpage">22499</infon>
+      <infon key="lpage">22509</infon>
+      <infon key="name_0">surname:Montanier;given-names:C. Y.</infon>
+      <infon key="name_1">surname:Correia;given-names:M. A.</infon>
+      <infon key="name_10">surname:Henrissat;given-names:B.</infon>
+      <infon key="name_11">surname:Fontes;given-names:C. M.</infon>
+      <infon key="name_12">surname:Gilbert;given-names:H. J.</infon>
+      <infon key="name_2">surname:Flint;given-names:J. E.</infon>
+      <infon key="name_3">surname:Zhu;given-names:Y.</infon>
+      <infon key="name_4">surname:Baslé;given-names:A.</infon>
+      <infon key="name_5">surname:McKee;given-names:L. S.</infon>
+      <infon key="name_6">surname:Prates;given-names:J. A.</infon>
+      <infon key="name_7">surname:Polizzi;given-names:S. J.</infon>
+      <infon key="name_8">surname:Coutinho;given-names:P. M.</infon>
+      <infon key="name_9">surname:Lewis;given-names:R. J.</infon>
+      <infon key="pub-id_pmid">21454512</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">J. Biol. Chem</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">286</infon>
+      <infon key="year">2011</infon>
+      <offset>48007</offset>
+      <text>A novel, noncatalytic carbohydrate-binding module displays specificity for galactose-containing polysaccharides through calcium-mediated oligomerization</text>
+    </passage>
+    <passage>
+      <infon key="fpage">1293</infon>
+      <infon key="lpage">1305</infon>
+      <infon key="name_0">surname:Vardakou;given-names:M.</infon>
+      <infon key="name_1">surname:Dumon;given-names:C.</infon>
+      <infon key="name_2">surname:Murray;given-names:J. W.</infon>
+      <infon key="name_3">surname:Christakopoulos;given-names:P.</infon>
+      <infon key="name_4">surname:Weiner;given-names:D. P.</infon>
+      <infon key="name_5">surname:Juge;given-names:N.</infon>
+      <infon key="name_6">surname:Lewis;given-names:R. J.</infon>
+      <infon key="name_7">surname:Gilbert;given-names:H. J.</infon>
+      <infon key="name_8">surname:Flint;given-names:J. E.</infon>
+      <infon key="pub-id_pmid">18078955</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">J. Mol. Biol</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">375</infon>
+      <infon key="year">2008</infon>
+      <offset>48160</offset>
+      <text>Understanding the structural basis for substrate and inhibitor recognition in eukaryotic GH11 xylanases</text>
+    </passage>
+    <passage>
+      <infon key="fpage">607</infon>
+      <infon key="lpage">614</infon>
+      <infon key="name_0">surname:Beylot;given-names:M. H.</infon>
+      <infon key="name_1">surname:McKie;given-names:V. A.</infon>
+      <infon key="name_2">surname:Voragen;given-names:A. G.</infon>
+      <infon key="name_3">surname:Doeswijk-Voragen;given-names:C. H.</infon>
+      <infon key="name_4">surname:Gilbert;given-names:H. J.</infon>
+      <infon key="pub-id_pmid">11535122</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Biochem. J</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">358</infon>
+      <infon key="year">2001</infon>
+      <offset>48264</offset>
+      <text>The Pseudomonas cellulosa glycoside hydrolase family 51 arabinofuranosidase exhibits wide substrate specificity</text>
+    </passage>
+    <passage>
+      <infon key="fpage">2942</infon>
+      <infon key="lpage">2951</infon>
+      <infon key="name_0">surname:Charnock;given-names:S. J.</infon>
+      <infon key="name_1">surname:Lakey;given-names:J. H.</infon>
+      <infon key="name_2">surname:Virden;given-names:R.</infon>
+      <infon key="name_3">surname:Hughes;given-names:N.</infon>
+      <infon key="name_4">surname:Sinnott;given-names:M. L.</infon>
+      <infon key="name_5">surname:Hazlewood;given-names:G. P.</infon>
+      <infon key="name_6">surname:Pickersgill;given-names:R.</infon>
+      <infon key="name_7">surname:Gilbert;given-names:H. J.</infon>
+      <infon key="pub-id_pmid">9006940</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">J. Biol. Chem</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">272</infon>
+      <infon key="year">1997</infon>
+      <offset>48376</offset>
+      <text>Key residues in subsite F play a critical role in the activity of Pseudomonas fluorescens subspecies cellulosa xylanase A against xylooligosaccharides but not against highly polymeric substrates such as xylan</text>
+    </passage>
+    <passage>
+      <infon key="fpage">32187</infon>
+      <infon key="lpage">32199</infon>
+      <infon key="name_0">surname:Charnock;given-names:S. J.</infon>
+      <infon key="name_1">surname:Spurway;given-names:T. D.</infon>
+      <infon key="name_2">surname:Xie;given-names:H.</infon>
+      <infon key="name_3">surname:Beylot;given-names:M. H.</infon>
+      <infon key="name_4">surname:Virden;given-names:R.</infon>
+      <infon key="name_5">surname:Warren;given-names:R. A.</infon>
+      <infon key="name_6">surname:Hazlewood;given-names:G. P.</infon>
+      <infon key="name_7">surname:Gilbert;given-names:H. J.</infon>
+      <infon key="pub-id_pmid">9822697</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">J. Biol. Chem</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">273</infon>
+      <infon key="year">1998</infon>
+      <offset>48585</offset>
+      <text>The topology of the substrate binding clefts of glycosyl hydrolase family 10 xylanases are not conserved</text>
+    </passage>
+    <passage>
+      <infon key="fpage">575</infon>
+      <infon key="lpage">585</infon>
+      <infon key="name_0">surname:Fujimoto;given-names:Z.</infon>
+      <infon key="name_1">surname:Kuno;given-names:A.</infon>
+      <infon key="name_2">surname:Kaneko;given-names:S.</infon>
+      <infon key="name_3">surname:Yoshida;given-names:S.</infon>
+      <infon key="name_4">surname:Kobayashi;given-names:H.</infon>
+      <infon key="name_5">surname:Kusakabe;given-names:I.</infon>
+      <infon key="name_6">surname:Mizuno;given-names:H.</infon>
+      <infon key="pub-id_pmid">10884353</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">J. Mol. Biol</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">300</infon>
+      <infon key="year">2000</infon>
+      <offset>48690</offset>
+      <text>Crystal structure of Streptomyces olivaceoviridis E-86 β-xylanase containing xylan-binding domain</text>
+    </passage>
+    <passage>
+      <infon key="fpage">25097</infon>
+      <infon key="lpage">25106</infon>
+      <infon key="name_0">surname:Ichinose;given-names:H.</infon>
+      <infon key="name_1">surname:Fujimoto;given-names:Z.</infon>
+      <infon key="name_2">surname:Honda;given-names:M.</infon>
+      <infon key="name_3">surname:Harazono;given-names:K.</infon>
+      <infon key="name_4">surname:Nishimoto;given-names:Y.</infon>
+      <infon key="name_5">surname:Uzura;given-names:A.</infon>
+      <infon key="name_6">surname:Kaneko;given-names:S.</infon>
+      <infon key="pub-id_pmid">19608743</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">J. Biol. Chem</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">284</infon>
+      <infon key="year">2009</infon>
+      <offset>48791</offset>
+      <text>A β-l-arabinopyranosidase from Streptomyces avermitilis is a novel member of glycoside hydrolase family 27</text>
+    </passage>
+    <passage>
+      <infon key="fpage">447</infon>
+      <infon key="lpage">457</infon>
+      <infon key="name_0">surname:Jiang;given-names:D.</infon>
+      <infon key="name_1">surname:Fan;given-names:J.</infon>
+      <infon key="name_2">surname:Wang;given-names:X.</infon>
+      <infon key="name_3">surname:Zhao;given-names:Y.</infon>
+      <infon key="name_4">surname:Huang;given-names:B.</infon>
+      <infon key="name_5">surname:Liu;given-names:J.</infon>
+      <infon key="name_6">surname:Zhang;given-names:X. C.</infon>
+      <infon key="pub-id_pmid">22960181</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">J. Struct. Biol</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">180</infon>
+      <infon key="year">2012</infon>
+      <offset>48901</offset>
+      <text>Crystal structure of 1,3Gal43A, an exo-beta-1,3-galactanase from Clostridium thermocellum</text>
+    </passage>
+    <passage>
+      <infon key="fpage">4246</infon>
+      <infon key="lpage">4254</infon>
+      <infon key="name_0">surname:Notenboom;given-names:V.</infon>
+      <infon key="name_1">surname:Boraston;given-names:A. B.</infon>
+      <infon key="name_2">surname:Williams;given-names:S. J.</infon>
+      <infon key="name_3">surname:Kilburn;given-names:D. G.</infon>
+      <infon key="name_4">surname:Rose;given-names:D. R.</infon>
+      <infon key="pub-id_pmid">11914070</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Biochemistry</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">41</infon>
+      <infon key="year">2002</infon>
+      <offset>48991</offset>
+      <text>High-resolution crystal structures of the lectin-like xylan binding domain from Streptomyces lividans xylanase 10A with bound substrates reveal a novel mode of xylan binding</text>
+    </passage>
+    <passage>
+      <infon key="fpage">769</infon>
+      <infon key="lpage">781</infon>
+      <infon key="name_0">surname:Boraston;given-names:A. B.</infon>
+      <infon key="name_1">surname:Bolam;given-names:D. N.</infon>
+      <infon key="name_2">surname:Gilbert;given-names:H. J.</infon>
+      <infon key="name_3">surname:Davies;given-names:G. J.</infon>
+      <infon key="pub-id_pmid">15214846</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Biochem. J</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">382</infon>
+      <infon key="year">2004</infon>
+      <offset>49165</offset>
+      <text>Carbohydrate-binding modules: fine-tuning polysaccharide recognition</text>
+    </passage>
+    <passage>
+      <infon key="fpage">669</infon>
+      <infon key="lpage">677</infon>
+      <infon key="name_0">surname:Gilbert;given-names:H. J.</infon>
+      <infon key="name_1">surname:Knox;given-names:J. P.</infon>
+      <infon key="name_2">surname:Boraston;given-names:A. B.</infon>
+      <infon key="pub-id_pmid">23769966</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Curr. Opin. Struct. Biol</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">23</infon>
+      <infon key="year">2013</infon>
+      <offset>49234</offset>
+      <text>Advances in understanding the molecular basis of plant cell wall polysaccharide recognition by carbohydrate-binding modules</text>
+    </passage>
+    <passage>
+      <infon key="fpage">2091</infon>
+      <infon key="lpage">2100</infon>
+      <infon key="name_0">surname:Poon;given-names:D. K.</infon>
+      <infon key="name_1">surname:Withers;given-names:S. G.</infon>
+      <infon key="name_2">surname:McIntosh;given-names:L. P.</infon>
+      <infon key="pub-id_pmid">17121820</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">J. Biol. Chem</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">282</infon>
+      <infon key="year">2007</infon>
+      <offset>49358</offset>
+      <text>Direct demonstration of the flexibility of the glycosylated proline-threonine linker in the Cellulomonas fimi xylanase Cex through NMR spectroscopic analysis</text>
+    </passage>
+    <passage>
+      <infon key="fpage">10572</infon>
+      <infon key="lpage">10586</infon>
+      <infon key="name_0">surname:Venditto;given-names:I.</infon>
+      <infon key="name_1">surname:Najmudin;given-names:S.</infon>
+      <infon key="name_2">surname:Luís;given-names:A. S.</infon>
+      <infon key="name_3">surname:Ferreira;given-names:L. M.</infon>
+      <infon key="name_4">surname:Sakka;given-names:K.</infon>
+      <infon key="name_5">surname:Knox;given-names:J. P.</infon>
+      <infon key="name_6">surname:Gilbert;given-names:H. J.</infon>
+      <infon key="name_7">surname:Fontes;given-names:C. M.</infon>
+      <infon key="pub-id_pmid">25713075</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">J. Biol. Chem</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">290</infon>
+      <infon key="year">2015</infon>
+      <offset>49516</offset>
+      <text>Family 46 carbohydrate-binding modules contribute to the enzymatic hydrolysis of xyloglucan and β-1,3–1,4-glucans through distinct mechanisms</text>
+    </passage>
+    <passage>
+      <infon key="fpage">15293</infon>
+      <infon key="lpage">15298</infon>
+      <infon key="name_0">surname:Hervé;given-names:C.</infon>
+      <infon key="name_1">surname:Rogowski;given-names:A.</infon>
+      <infon key="name_2">surname:Blake;given-names:A. W.</infon>
+      <infon key="name_3">surname:Marcus;given-names:S. E.</infon>
+      <infon key="name_4">surname:Gilbert;given-names:H. J.</infon>
+      <infon key="name_5">surname:Knox;given-names:J. P.</infon>
+      <infon key="pub-id_pmid">20696902</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Proc. Natl. Acad. Sci. U.S.A</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">107</infon>
+      <infon key="year">2010</infon>
+      <offset>49661</offset>
+      <text>Carbohydrate-binding modules promote the enzymatic deconstruction of intact plant cell walls by targeting and proximity effects</text>
+    </passage>
+    <passage>
+      <infon key="fpage">186</infon>
+      <infon key="name_0">surname:Aspeborg;given-names:H.</infon>
+      <infon key="name_1">surname:Coutinho;given-names:P. M.</infon>
+      <infon key="name_2">surname:Wang;given-names:Y.</infon>
+      <infon key="name_3">surname:Brumer;given-names:H.;suffix:3rd</infon>
+      <infon key="name_4">surname:Henrissat;given-names:B.</infon>
+      <infon key="pub-id_pmid">22992189</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">BMC Evol. Biol</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">12</infon>
+      <infon key="year">2012</infon>
+      <offset>49789</offset>
+      <text>Evolution, substrate specificity and subfamily classification of glycoside hydrolase family 5 (GH5)</text>
+    </passage>
+    <passage>
+      <infon key="fpage">165</infon>
+      <infon key="lpage">169</infon>
+      <infon key="name_0">surname:Cuskin;given-names:F.</infon>
+      <infon key="name_1">surname:Lowe;given-names:E. C.</infon>
+      <infon key="name_10">surname:Rogowski;given-names:A.</infon>
+      <infon key="name_11">surname:Hamilton;given-names:B. S.</infon>
+      <infon key="name_12">surname:Chen;given-names:R.</infon>
+      <infon key="name_13">surname:Tolbert;given-names:T. J.</infon>
+      <infon key="name_14">surname:Piens;given-names:K.</infon>
+      <infon key="name_2">surname:Temple;given-names:M. J.</infon>
+      <infon key="name_3">surname:Zhu;given-names:Y.</infon>
+      <infon key="name_4">surname:Cameron;given-names:E. A.</infon>
+      <infon key="name_5">surname:Pudlo;given-names:N. A.</infon>
+      <infon key="name_6">surname:Porter;given-names:N. T.</infon>
+      <infon key="name_7">surname:Urs;given-names:K.</infon>
+      <infon key="name_8">surname:Thompson;given-names:A. J.</infon>
+      <infon key="name_9">surname:Cartmell;given-names:A.</infon>
+      <infon key="pub-id_pmid">25567280</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Nature</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">517</infon>
+      <infon key="year">2015</infon>
+      <offset>49889</offset>
+      <text>Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism</text>
+    </passage>
+    <passage>
+      <infon key="fpage">1686</infon>
+      <infon key="lpage">1692</infon>
+      <infon key="name_0">surname:Mewis;given-names:K.</infon>
+      <infon key="name_1">surname:Lenfant;given-names:N.</infon>
+      <infon key="name_2">surname:Lombard;given-names:V.</infon>
+      <infon key="name_3">surname:Henrissat;given-names:B.</infon>
+      <infon key="pub-id_pmid">26729713</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Appl. Environ. Microbiol</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">82</infon>
+      <infon key="year">2016</infon>
+      <offset>49966</offset>
+      <text>Dividing the large glycoside hydrolase family 43 into subfamilies: a motivation for detailed enzyme characterization</text>
+    </passage>
+    <passage>
+      <infon key="fpage">12</infon>
+      <infon key="lpage">21</infon>
+      <infon key="name_0">surname:Chen;given-names:V. B.</infon>
+      <infon key="name_1">surname:Arendall;given-names:W. B.;suffix:3rd</infon>
+      <infon key="name_2">surname:Headd;given-names:J. J.</infon>
+      <infon key="name_3">surname:Keedy;given-names:D. A.</infon>
+      <infon key="name_4">surname:Immormino;given-names:R. M.</infon>
+      <infon key="name_5">surname:Kapral;given-names:G. J.</infon>
+      <infon key="name_6">surname:Murray;given-names:L. W.</infon>
+      <infon key="name_7">surname:Richardson;given-names:J. S.</infon>
+      <infon key="name_8">surname:Richardson;given-names:D. C.</infon>
+      <infon key="pub-id_pmid">20057044</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Acta Crystallogr. D Biol. Crystallogr</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">66</infon>
+      <infon key="year">2010</infon>
+      <offset>50083</offset>
+      <text>MolProbity: all-atom structure validation for macromolecular crystallography</text>
+    </passage>
+    <passage>
+      <infon key="fpage">14077</infon>
+      <infon key="lpage">14082</infon>
+      <infon key="name_0">surname:Charnock;given-names:S. J.</infon>
+      <infon key="name_1">surname:Bolam;given-names:D. N.</infon>
+      <infon key="name_2">surname:Nurizzo;given-names:D.</infon>
+      <infon key="name_3">surname:Szabó;given-names:L.</infon>
+      <infon key="name_4">surname:McKie;given-names:V. A.</infon>
+      <infon key="name_5">surname:Gilbert;given-names:H. J.</infon>
+      <infon key="name_6">surname:Davies;given-names:G. J.</infon>
+      <infon key="pub-id_pmid">12391332</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Proc. Natl. Acad. Sci. U.S.A</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">99</infon>
+      <infon key="year">2002</infon>
+      <offset>50160</offset>
+      <text>Promiscuity in ligand-binding: the three-dimensional structure of a Piromyces carbohydrate-binding module, CBM29–2, in complex with cello- and mannohexaose</text>
+    </passage>
+    <passage>
+      <infon key="fpage">426</infon>
+      <infon key="lpage">428</infon>
+      <infon key="name_0">surname:Miller;given-names:G. L.</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Anal. Chem</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">31</infon>
+      <infon key="year">1959</infon>
+      <offset>50318</offset>
+      <text>Use of dinitrosalicylic acid reagent for determination of reducing sugar</text>
+    </passage>
+    <passage>
+      <infon key="fpage">2697</infon>
+      <infon key="lpage">2702</infon>
+      <infon key="name_0">surname:Proctor;given-names:M. R.</infon>
+      <infon key="name_1">surname:Taylor;given-names:E. J.</infon>
+      <infon key="name_2">surname:Nurizzo;given-names:D.</infon>
+      <infon key="name_3">surname:Turkenburg;given-names:J. P.</infon>
+      <infon key="name_4">surname:Lloyd;given-names:R. M.</infon>
+      <infon key="name_5">surname:Vardakou;given-names:M.</infon>
+      <infon key="name_6">surname:Davies;given-names:G. J.</infon>
+      <infon key="name_7">surname:Gilbert;given-names:H. J.</infon>
+      <infon key="pub-id_pmid">15708971</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Proc. Natl. Acad. Sci. U.S.A</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">102</infon>
+      <infon key="year">2005</infon>
+      <offset>50391</offset>
+      <text>Tailored catalysts for plant cell-wall degradation: Redesigning the exo/endo preference of Cellvibrio japonicus arabinanase 43A</text>
+    </passage>
+    <passage>
+      <infon key="fpage">494</infon>
+      <infon key="lpage">505</infon>
+      <infon key="name_0">surname:Bui;given-names:N. K.</infon>
+      <infon key="name_1">surname:Gray;given-names:J.</infon>
+      <infon key="name_2">surname:Schwarz;given-names:H.</infon>
+      <infon key="name_3">surname:Schumann;given-names:P.</infon>
+      <infon key="name_4">surname:Blanot;given-names:D.</infon>
+      <infon key="name_5">surname:Vollmer;given-names:W.</infon>
+      <infon key="pub-id_pmid">18996994</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">J. Bacteriol</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">191</infon>
+      <infon key="year">2009</infon>
+      <offset>50519</offset>
+      <text>The peptidoglycan sacculus of Myxococcus xanthus has unusual structural features and is degraded during glycerol-induced myxospore development</text>
+    </passage>
+    <passage>
+      <infon key="name_0">surname:Leslie;given-names:A. G. W.</infon>
+      <infon key="name_1">surname:Powell;given-names:H. R.</infon>
+      <infon key="name_2">surname:Read;given-names:R. J.</infon>
+      <infon key="name_3">surname:Sussman;given-names:J. L.</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Evolving Methods for Macromolecular Crystallography</infon>
+      <infon key="type">ref</infon>
+      <infon key="year">2007</infon>
+      <offset>50662</offset>
+      <text>Processing diffraction data with mosflm</text>
+    </passage>
+    <passage>
+      <infon key="fpage">72</infon>
+      <infon key="lpage">82</infon>
+      <infon key="name_0">surname:Evans;given-names:P.</infon>
+      <infon key="pub-id_pmid">16369096</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Acta Crystallogr. D Biol. Crystallogr</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">62</infon>
+      <infon key="year">2006</infon>
+      <offset>50702</offset>
+      <text>Scaling and assessment of data quality</text>
+    </passage>
+    <passage>
+      <infon key="fpage">833</infon>
+      <infon key="lpage">836</infon>
+      <infon key="name_0">surname:Brás;given-names:J. L.</infon>
+      <infon key="name_1">surname:Correia;given-names:M. A.</infon>
+      <infon key="name_2">surname:Romão;given-names:M. J.</infon>
+      <infon key="name_3">surname:Prates;given-names:J. A.</infon>
+      <infon key="name_4">surname:Fontes;given-names:C. M.</infon>
+      <infon key="name_5">surname:Najmudin;given-names:S.</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">67</infon>
+      <infon key="year">2011</infon>
+      <offset>50741</offset>
+      <text>Purification, crystallization and preliminary x-ray characterization of the pentamodular arabinoxylanase CtXyl5A from Clostridium thermocellum</text>
+    </passage>
+    <passage>
+      <infon key="fpage">540</infon>
+      <infon key="lpage">545</infon>
+      <infon key="name_0">surname:Stierand;given-names:K.</infon>
+      <infon key="name_1">surname:Rarey;given-names:M.</infon>
+      <infon key="pub-id_pmid">24900245</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">ACS Med. Chem. Lett</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">1</infon>
+      <infon key="year">2010</infon>
+      <offset>50884</offset>
+      <text>Drawing the PDB: protein-ligand complexes in two dimensions</text>
+    </passage>
+    <passage>
+      <infon key="fpage">658</infon>
+      <infon key="lpage">674</infon>
+      <infon key="name_0">surname:McCoy;given-names:A. J.</infon>
+      <infon key="name_1">surname:Grosse-Kunstleve;given-names:R. W.</infon>
+      <infon key="name_2">surname:Adams;given-names:P. D.</infon>
+      <infon key="name_3">surname:Winn;given-names:M. D.</infon>
+      <infon key="name_4">surname:Storoni;given-names:L. C.</infon>
+      <infon key="name_5">surname:Read;given-names:R. J.</infon>
+      <infon key="pub-id_pmid">19461840</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">J. Appl. Crystallogr</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">40</infon>
+      <infon key="year">2007</infon>
+      <offset>50944</offset>
+      <text>Phaser crystallographic software</text>
+    </passage>
+    <passage>
+      <infon key="fpage">1002</infon>
+      <infon key="lpage">1011</infon>
+      <infon key="name_0">surname:Cowtan;given-names:K.</infon>
+      <infon key="pub-id_pmid">16929101</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Acta Crystallogr. D Biol. Crystallogr</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">62</infon>
+      <infon key="year">2006</infon>
+      <offset>50977</offset>
+      <text>The Buccaneer software for automated model building: 1. Tracing protein chains</text>
+    </passage>
+    <passage>
+      <infon key="fpage">61</infon>
+      <infon key="lpage">69</infon>
+      <infon key="name_0">surname:Terwilliger;given-names:T. C.</infon>
+      <infon key="name_1">surname:Grosse-Kunstleve;given-names:R. W.</infon>
+      <infon key="name_2">surname:Afonine;given-names:P. V.</infon>
+      <infon key="name_3">surname:Moriarty;given-names:N. W.</infon>
+      <infon key="name_4">surname:Zwart;given-names:P. H.</infon>
+      <infon key="name_5">surname:Hung;given-names:L. W.</infon>
+      <infon key="name_6">surname:Read;given-names:R. J.</infon>
+      <infon key="name_7">surname:Adams;given-names:P. D.</infon>
+      <infon key="pub-id_pmid">18094468</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Acta Crystallogr. D Biol. Crystallogr</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">64</infon>
+      <infon key="year">2008</infon>
+      <offset>51056</offset>
+      <text>Iterative model building, structure refinement and density modification with the PHENIX AutoBuild wizard</text>
+    </passage>
+    <passage>
+      <infon key="fpage">2126</infon>
+      <infon key="lpage">2132</infon>
+      <infon key="name_0">surname:Emsley;given-names:P.</infon>
+      <infon key="name_1">surname:Cowtan;given-names:K.</infon>
+      <infon key="pub-id_pmid">15572765</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Acta Crystallogr. D Biol. Crystallogr</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">60</infon>
+      <infon key="year">2004</infon>
+      <offset>51161</offset>
+      <text>Coot: model-building tools for molecular graphics</text>
+    </passage>
+    <passage>
+      <infon key="fpage">355</infon>
+      <infon key="lpage">367</infon>
+      <infon key="name_0">surname:Murshudov;given-names:G. N.</infon>
+      <infon key="name_1">surname:Skubák;given-names:P.</infon>
+      <infon key="name_2">surname:Lebedev;given-names:A. A.</infon>
+      <infon key="name_3">surname:Pannu;given-names:N. S.</infon>
+      <infon key="name_4">surname:Steiner;given-names:R. A.</infon>
+      <infon key="name_5">surname:Nicholls;given-names:R. A.</infon>
+      <infon key="name_6">surname:Winn;given-names:M. D.</infon>
+      <infon key="name_7">surname:Long;given-names:F.</infon>
+      <infon key="name_8">surname:Vagin;given-names:A. A.</infon>
+      <infon key="pub-id_pmid">21460454</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Acta Crystallogr. D Biol. Crystallogr</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">67</infon>
+      <infon key="year">2011</infon>
+      <offset>51211</offset>
+      <text>REFMAC5 for the refinement of macromolecular crystal structures</text>
+    </passage>
+    <passage>
+      <infon key="fpage">D355</infon>
+      <infon key="lpage">D359</infon>
+      <infon key="name_0">surname:Laskowski;given-names:R. A.</infon>
+      <infon key="pub-id_pmid">18996896</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Nucleic Acids Res</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">37</infon>
+      <infon key="year">2009</infon>
+      <offset>51275</offset>
+      <text>PDBsum new things</text>
+    </passage>
+    <passage>
+      <infon key="fpage">15483</infon>
+      <infon key="lpage">15495</infon>
+      <infon key="name_0">surname:Cartmell;given-names:A.</infon>
+      <infon key="name_1">surname:McKee;given-names:L. S.</infon>
+      <infon key="name_10">surname:Marles-Wright;given-names:J.</infon>
+      <infon key="name_2">surname:Peña;given-names:M. J.</infon>
+      <infon key="name_3">surname:Larsbrink;given-names:J.</infon>
+      <infon key="name_4">surname:Brumer;given-names:H.</infon>
+      <infon key="name_5">surname:Kaneko;given-names:S.</infon>
+      <infon key="name_6">surname:Ichinose;given-names:H.</infon>
+      <infon key="name_7">surname:Lewis;given-names:R. J.</infon>
+      <infon key="name_8">surname:Viksø-Nielsen;given-names:A.</infon>
+      <infon key="name_9">surname:Gilbert;given-names:H. J.</infon>
+      <infon key="pub-id_pmid">21339299</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">J. Biol. Chem</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">286</infon>
+      <infon key="year">2011</infon>
+      <offset>51293</offset>
+      <text>The structure and function of an arabinan-specific α-1,2-arabinofuranosidase identified from screening the activities of bacterial GH43 glycoside hydrolases</text>
+    </passage>
+    <passage>
+      <infon key="fpage">125</infon>
+      <infon key="lpage">132</infon>
+      <infon key="name_0">surname:Kabsch;given-names:W.</infon>
+      <infon key="pub-id_pmid">20124692</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">Acta Crystallogr D Biol. Crystallogr</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">66</infon>
+      <infon key="year">2010</infon>
+      <offset>51454</offset>
+      <text>XDS</text>
+    </passage>
+    <passage>
+      <infon key="fpage">1022</infon>
+      <infon key="lpage">1025</infon>
+      <infon key="name_0">surname:Vagin;given-names:A.</infon>
+      <infon key="name_1">surname:Teplyakov;given-names:A.</infon>
+      <infon key="section_type">REF</infon>
+      <infon key="source">J. Appl. Crystallogr</infon>
+      <infon key="type">ref</infon>
+      <infon key="volume">30</infon>
+      <infon key="year">1997</infon>
+      <offset>51458</offset>
+      <text>MolRep: an automated program for molecular replacement</text>
+    </passage>
+  </document>
+</collection>