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I like the French image. Again, just to sorta re-state where I'm coming from, even if the nebulizer girl was perfectly lit in high resolution, the main trouble is that this doesn't ""look"" like cystic fibrosis. There's absolutely nothing in it to the layman which says ""this is what cystic fibrosis, and cystic fibrosis alone, looks like"" - it's a girl with a breathing mask. The image could be used in the treatment subsection (where I originally placed it) or somewhere else in the article, but the top image should be as singularly ""cystic fibrosis"" as the title itself. For diseases like, off the top of my head, lupus, clubfoot, ALS, spina bifida, or Downs syndrome, images of people could be very suitable for the lede. But for other diseases, a picture of a person suffering from the disease really doesn't work - a person with a runny nose could have the flu, or could just have allergies. There's nothing so strikingly visual about how the flu manifests itself in a human being that justifies a picture of a person with the flu in the lede when a picture of the bug itself can be used. Same with Tay-Sachs, or Alzheimers, or AIDS - none of these articles have a picture of a human being in their lede, and for good reason. It's an article about cystic fibrosis, not ""living with"" cystic fibrosis, and as such, we should strive to present readers with an image that's as singularly CF as possible. The image of the girl is cute and touching and is suitable enough for the ""treatment"" section, but is unfitting of being the lead image in the article.   "