Question: Which protein can interact with amphetamine ?
Paraphrase: What protein can interact with amphetamine?
SPARQL (Wikidata):  select distinct ?obj where { wd:Q179452 wdt:P129 ?obj . ?obj wdt:P31 wd:Q8054 } 
Answer: Trace amine associated receptor 1, 5-hydroxytryptamine receptor 1A