Question: Cortisol interacts with what protein?
Paraphrase: What protein interacts with Cortisol?
SPARQL (Wikidata):  select distinct ?sbj where { ?sbj wdt:P129 wd:Q190875 . ?sbj wdt:P31 wd:Q8054 } 
Answer: Nuclear receptor subfamily 3 group C member 1, Nuclear receptor subfamily 3 group C member 2