Question: What chemical compounds have a significant interaction with cocaine?
Paraphrase: What synthetic mixes have a noteworthy association with cocaine?
SPARQL (Wikidata):  select distinct ?sbj where { ?sbj wdt:P769 wd:Q41576 . ?sbj wdt:P31 wd:Q11173 } 
Answer: clarithromycin, pimozide, azithromycin, droperidol, erythromycin, haloperidol, chlorpromazine, anagrelide, dronedarone, amiodarone, quinidine, sotalol, pentamidine, procainamide, terfenadine, sevoflurane, flecainide, sulpiride, chloroquine, astemizole, escitalopram, domperidone, moxifloxacin, disopyramide, cisapride, halofantrine, sparfloxacin, dofetilide, ibutilide, bepridil, mesoridazine, probucol, arsenic trioxide, thioridazine