Question: In which bio pharmaceutical has the highest defined daily dose ?
Paraphrase: What bio pharmaceutical has the defined daily dose that is the highest?
SPARQL (Wikidata): select ?ent where { ?ent wdt:P31 wd:Q679692 . ?ent wdt:P4250 ?obj } ORDER BY DESC(?obj)LIMIT 5 
Answer: eculizumab, Drotrecogin alfa, Basiliximab, Tenecteplase, Siltuximab