OpenRaiser/Intern-Atlas huggingface dataset:
Soft Graph Clustering for single-cell RNA Sequencing Data
Venue: arXiv cs.LG 2025
Year: 2025

Clustering analysis is fundamental in single-cell RNA sequencing (scRNA-seq) data analysis for elucidating cellular heterogeneity and diversity. Recent graph-based scRNA-seq clustering methods, particularly graph neural networks (GNNs), have significantly improved in tackling the challenges of high-dimension, high-sparsity, and frequent dropout events that lead to ambiguous cell population boundaries. However, their reliance on hard graph constructions derived from thresholded similarity matrices presents challenges:(i) The simplification of intercellular relationships into binary edges (0 or 1) by applying thresholds, which restricts the capture of continuous similarity features among cells and leads to significant information loss.(ii) The presence of significant inter-cluster connections within hard graphs, which can confuse GNN methods that rely heavily on graph structures, potentially causing erroneous message propagation and biased clustering outcomes. To tackle these challenges, we introduce scSGC, a Soft Graph Clustering for single-cell RNA sequencing data, which aims to more accurately characterize continuous similarities among cells through non-binary edge weights, thereby mitigating the limitations of rigid data structures. The scSGC framework comprises three core components: (i) a zero-inflated negative binomial (ZINB)-based feature autoencoder; (ii) a dual-channel cut-informed soft graph embedding module; and (iii) an optimal transport-based clustering optimization module. Extensive experiments across ten datasets demonstrate that scSGC outperforms 13 state-of-the-art clustering models in clustering accuracy, cell type annotation, and computational efficiency. These results highlight its substantial potential to advance scRNA-seq data analysis and deepen our understanding of cellular heterogeneity.
MixLoRA-DSI: Dynamically Expandable Mixture-of-LoRA Experts for Rehearsal-Free Generative Retrieval over Dynamic Corpora
Venue: arXiv cs.IR 2025
Year: 2025

Continually updating model-based indexes in generative retrieval with new documents remains challenging, as full retraining is computationally expensive and impractical under resource constraints. We propose MixLoRA-DSI, a novel framework that combines an expandable mixture of Low-Rank Adaptation experts with a layer-wise out-of-distribution (OOD)-driven expansion strategy. Instead of allocating new experts for each new corpus, our proposed expansion strategy enables sublinear parameter growth by selectively introducing new experts only when significant number of OOD documents are detected. Experiments on NQ320k and MS MARCO Passage demonstrate that MixLoRA-DSI outperforms full-model update baselines, with minimal parameter overhead and substantially lower training costs.
Intelligent Task Management via Dynamic Multi-region Division in LEO Satellite Networks
Venue: arXiv cs.DC 2025
Year: 2025

As a key complement to terrestrial networks and a fundamental component of future 6G systems, Low Earth Orbit (LEO) satellite networks are expected to provide high-quality communication services when integrated with ground-based infrastructure, thereby attracting significant research interest. However, the limited satellite onboard resources and the uneven distribution of computational workloads often result in congestion along inter-satellite links (ISLs) that degrades task processing efficiency. Effectively managing the dynamic and large-scale topology of LEO networks to ensure balanced task distribution remains a critical challenge. To this end, we propose a dynamic multi-region division framework for intelligent task management in LEO satellite networks. This framework optimizes both intra- and inter-region routing to minimize task delay while balancing the utilization of computational and communication resources. Based on this framework, we propose a dynamic multi-region division algorithm based on the Genetic Algorithm (GA), which adaptively adjusts the size of each region based on the workload status of individual satellites. Additionally, we incorporate an adaptive routing algorithm and a task splitting and offloading scheme based on Multi-Agent Deep Deterministic Policy Gradient (MA-DDPG) to effectively accommodate the arriving tasks. Simulation results demonstrate that our proposed framework outperforms comparative methods in terms of the task delay, energy consumption per task, and task completion rate.
Enhancing Retrieval Augmented Generation with Hierarchical Text Segmentation Chunking
Venue: arXiv cs.CL 2025
Year: 2025

Retrieval-Augmented Generation (RAG) systems commonly use chunking strategies for retrieval, which enhance large language models (LLMs) by enabling them to access external knowledge, ensuring that the retrieved information is up-to-date and domain-specific. However, traditional methods often fail to create chunks that capture sufficient semantic meaning, as they do not account for the underlying textual structure. This paper proposes a novel framework that enhances RAG by integrating hierarchical text segmentation and clustering to generate more meaningful and semantically coherent chunks. During inference, the framework retrieves information by leveraging both segment-level and cluster-level vector representations, thereby increasing the likelihood of retrieving more precise and contextually relevant information. Evaluations on the NarrativeQA, QuALITY, and QASPER datasets indicate that the proposed method achieved improved results compared to traditional chunking techniques.
Iceberg: Enhancing HLS Modeling with Synthetic Data
Venue: arXiv cs.LG 2025
Year: 2025

Deep learning-based prediction models for High-Level Synthesis (HLS) of hardware designs often struggle to generalize. In this paper, we study how to close the generalizability gap of these models through pretraining on synthetic data and introduce Iceberg, a synthetic data augmentation approach that expands both large language model (LLM)-generated programs and weak labels of unseen design configurations. Our weak label generation method is integrated with an in-context model architecture, enabling meta-learning from actual and proximate labels. Iceberg improves the geometric mean modeling accuracy by $86.4\%$ when adapt to six real-world applications with few-shot examples and achieves a $2.47\times$ and a $1.12\times$ better offline DSE performance when adapting to two different test datasets. Our open-sourced code is here: https://github.com/UCLA-VAST/iceberg
TextOmics-Guided Diffusion for Hit-like Molecular Generation
Venue: arXiv cs.CL 2025
Year: 2025

Hit-like molecular generation with therapeutic potential is essential for target-specific drug discovery. However, the field lacks heterogeneous data and unified frameworks for integrating diverse molecular representations. To bridge this gap, we introduce TextOmics, a pioneering benchmark that establishes one-to-one correspondences between omics expressions and molecular textual descriptions. TextOmics provides a heterogeneous dataset that facilitates molecular generation through representations alignment. Built upon this foundation, we propose ToDi, a generative framework that jointly conditions on omics expressions and molecular textual descriptions to produce biologically relevant, chemically valid, hit-like molecules. ToDi leverages two encoders (OmicsEn and TextEn) to capture multi-level biological and semantic associations, and develops conditional diffusion (DiffGen) for controllable generation. Extensive experiments confirm the effectiveness of TextOmics and demonstrate ToDi outperforms existing state-of-the-art approaches, while also showcasing remarkable potential in zero-shot therapeutic molecular generation. Sources are available at: https://github.com/hala-ToDi.
Leveraging Swin Transformer for enhanced diagnosis of Alzheimer's disease using multi-shell diffusion MRI
Venue: arXiv cs.CV 2025
Year: 2025

Objective: This study aims to support early diagnosis of Alzheimer's disease and detection of amyloid accumulation by leveraging the microstructural information available in multi-shell diffusion MRI (dMRI) data, using a vision transformer-based deep learning framework. Methods: We present a classification pipeline that employs the Swin Transformer, a hierarchical vision transformer model, on multi-shell dMRI data for the classification of Alzheimer's disease and amyloid presence. Key metrics from DTI and NODDI were extracted and projected onto 2D planes to enable transfer learning with ImageNet-pretrained models. To efficiently adapt the transformer to limited labeled neuroimaging data, we integrated Low-Rank Adaptation. We assessed the framework on diagnostic group prediction (cognitively normal, mild cognitive impairment, Alzheimer's disease dementia) and amyloid status classification. Results: The framework achieved competitive classification results within the scope of multi-shell dMRI-based features, with the best balanced accuracy of 95.2% for distinguishing cognitively normal individuals from those with Alzheimer's disease dementia using NODDI metrics. For amyloid detection, it reached 77.2% balanced accuracy in distinguishing amyloid-positive mild cognitive impairment/Alzheimer's disease dementia subjects from amyloid-negative cognitively normal subjects, and 67.9% for identifying amyloid-positive individuals among cognitively normal subjects. Grad-CAM-based explainability analysis identified clinically relevant brain regions, including the parahippocampal gyrus and hippocampus, as key contributors to model predictions. Conclusion: This study demonstrates the promise of diffusion MRI and transformer-based architectures for early detection of Alzheimer's disease and amyloid pathology, supporting biomarker-driven diagnostics in data-limited biomedical settings.
The Man Behind the Sound: Demystifying Audio Private Attribute Profiling via Multimodal Large Language Model Agents
Venue: arXiv cs.CR 2025
Year: 2025

Our research uncovers a novel privacy risk associated with multimodal large language models (MLLMs): the ability to infer sensitive personal attributes from audio data -- a technique we term audio private attribute profiling. This capability poses a significant threat, as audio can be covertly captured without direct interaction or visibility. Moreover, compared to images and text, audio carries unique characteristics, such as tone and pitch, which can be exploited for more detailed profiling. However, two key challenges exist in understanding MLLM-employed private attribute profiling from audio: (1) the lack of audio benchmark datasets with sensitive attribute annotations and (2) the limited ability of current MLLMs to infer such attributes directly from audio. To address these challenges, we introduce AP^2, an audio benchmark dataset that consists of two subsets collected and composed from real-world data, and both are annotated with sensitive attribute labels. Additionally, we propose Gifts, a hybrid multi-agent framework that leverages the complementary strengths of audio-language models (ALMs) and large language models (LLMs) to enhance inference capabilities. Gifts employs an LLM to guide the ALM in inferring sensitive attributes, then forensically analyzes and consolidates the ALM's inferences, overcoming severe hallucinations of existing ALMs in generating long-context responses. Our evaluations demonstrate that Gifts significantly outperforms baseline approaches in inferring sensitive attributes. Finally, we investigate model-level and data-level defense strategies to mitigate the risks of audio private attribute profiling. Our work validates the feasibility of audio-based privacy attacks using MLLMs, highlighting the need for robust defenses, and provides a dataset and framework to facilitate future research.
Qualitative Study for LLM-assisted Design Study Process: Strategies, Challenges, and Roles
Venue: arXiv cs.HC 2025
Year: 2025

Design studies aim to create visualization solutions for real-world problems of different application domains. Recently, the emergence of large language models (LLMs) has introduced new opportunities to enhance the design study process, providing capabilities such as creative problem-solving, data handling, and insightful analysis. However, despite their growing popularity, there remains a lack of systematic understanding of how LLMs can effectively assist researchers in visualization-specific design studies. In this paper, we conducted a multi-stage qualitative study to fill this gap, involving 30 design study researchers from diverse backgrounds and expertise levels. Through in-depth interviews and carefully-designed questionnaires, we investigated strategies for utilizing LLMs, the challenges encountered, and the practices used to overcome them. We further compiled and summarized the roles that LLMs can play across different stages of the design study process. Our findings highlight practical implications to inform visualization practitioners, and provide a framework for leveraging LLMs to enhance the design study process in visualization research.
LifelongPR: Lifelong point cloud place recognition based on sample replay and prompt learning
Venue: arXiv cs.CV 2025
Year: 2025

Point cloud place recognition (PCPR) determines the geo-location within a prebuilt map and plays a crucial role in geoscience and robotics applications such as autonomous driving, intelligent transportation, and augmented reality. In real-world large-scale deployments of a geographic positioning system, PCPR models must continuously acquire, update, and accumulate knowledge to adapt to diverse and dynamic environments, i.e., the ability known as continual learning (CL). However, existing PCPR models often suffer from catastrophic forgetting, leading to significant performance degradation in previously learned scenes when adapting to new environments or sensor types. This results in poor model scalability, increased maintenance costs, and system deployment difficulties, undermining the practicality of PCPR. To address these issues, we propose LifelongPR, a novel continual learning framework for PCPR, which effectively extracts and fuses knowledge from sequential point cloud data. First, to alleviate the knowledge loss, we propose a replay sample selection method that dynamically allocates sample sizes according to each dataset's information quantity and selects spatially diverse samples for maximal representativeness. Second, to handle domain shifts, we design a prompt learning-based CL framework with a lightweight prompt module and a two-stage training strategy, enabling domain-specific feature adaptation while minimizing forgetting. Comprehensive experiments on large-scale public and self-collected datasets are conducted to validate the effectiveness of the proposed method. Compared with state-of-the-art (SOTA) methods, our method achieves 6.50% improvement in mIR@1, 7.96% improvement in mR@1, and an 8.95% reduction in F. The code and pre-trained models are publicly available at https://github.com/zouxianghong/LifelongPR.
MP-RBFN: Learning-based Vehicle Motion Primitives using Radial Basis Function Networks
Venue: arXiv cs.RO 2025
Year: 2025

This research introduces MP-RBFN, a novel formulation leveraging Radial Basis Function Networks for efficiently learning Motion Primitives derived from optimal control problems for autonomous driving. While traditional motion planning approaches based on optimization are highly accurate, they are often computationally prohibitive. In contrast, sampling-based methods demonstrate high performance but impose constraints on the geometric shape of trajectories. MP-RBFN combines the strengths of both by coupling the high-fidelity trajectory generation of sampling-based methods with an accurate description of vehicle dynamics. Empirical results show compelling performance compared to previous methods, achieving a precise description of motion primitives at low inference times. MP-RBFN yields a seven times higher accuracy in generating optimized motion primitives compared to existing semi-analytic approaches. We demonstrate the practical applicability of MP-RBFN for motion planning by integrating the method into a sampling-based trajectory planner. MP-RBFN is available as open-source software at https://github.com/TUM-AVS/RBFN-Motion-Primitives.
Lightweight Model for Poultry Disease Detection from Fecal Images Using Multi-Color Space Feature Optimization and Machine Learning
Venue: arXiv cs.CV 2025
Year: 2025

Poultry farming is a vital component of the global food supply chain, yet it remains highly vulnerable to infectious diseases such as coccidiosis, salmonellosis, and Newcastle disease. This study proposes a lightweight machine learning-based approach to detect these diseases by analyzing poultry fecal images. We utilize multi-color space feature extraction (RGB, HSV, LAB) and explore a wide range of color, texture, and shape-based descriptors, including color histograms, local binary patterns (LBP), wavelet transforms, and edge detectors. Through a systematic ablation study and dimensionality reduction using PCA and XGBoost feature selection, we identify a compact global feature set that balances accuracy and computational efficiency. An artificial neural network (ANN) classifier trained on these features achieved 95.85% accuracy while requiring no GPU and only 638 seconds of execution time in Google Colab. Compared to deep learning models such as Xception and MobileNetV3, our proposed model offers comparable accuracy with drastically lower resource usage. This work demonstrates a cost-effective, interpretable, and scalable alternative to deep learning for real-time poultry disease detection in low-resource agricultural settings.
Frequency Regulation for Exposure Bias Mitigation in Diffusion Models
Venue: arXiv cs.CV 2025
Year: 2025

Diffusion models exhibit impressive generative capabilities but are significantly impacted by exposure bias. In this paper, we make a key observation: the energy of predicted noisy samples in the reverse process continuously declines compared to perturbed samples in the forward process. Building on this, we identify two important findings: 1) The reduction in energy follows distinct patterns in the low-frequency and high-frequency subbands; 2) The subband energy of reverse-process reconstructed samples is consistently lower than that of forward-process ones, and both are lower than the original data samples. Based on the first finding, we introduce a dynamic frequency regulation mechanism utilizing wavelet transforms, which separately adjusts the low- and high-frequency subbands. Leveraging the second insight, we derive the rigorous mathematical form of exposure bias. It is worth noting that, our method is training-free and plug-and-play, significantly improving the generative quality of various diffusion models and frameworks with negligible computational cost. The source code is available at https://github.com/kunzhan/wpp.
Foundation Model Driven Robotics: A Comprehensive Review
Venue: arXiv cs.RO 2025
Year: 2025

The rapid emergence of foundation models, particularly Large Language Models (LLMs) and Vision-Language Models (VLMs), has introduced a transformative paradigm in robotics. These models offer powerful capabilities in semantic understanding, high-level reasoning, and cross-modal generalization, enabling significant advances in perception, planning, control, and human-robot interaction. This critical review provides a structured synthesis of recent developments, categorizing applications across simulation-driven design, open-world execution, sim-to-real transfer, and adaptable robotics. Unlike existing surveys that emphasize isolated capabilities, this work highlights integrated, system-level strategies and evaluates their practical feasibility in real-world environments. Key enabling trends such as procedural scene generation, policy generalization, and multimodal reasoning are discussed alongside core bottlenecks, including limited embodiment, lack of multimodal data, safety risks, and computational constraints. Through this lens, this paper identifies both the architectural strengths and critical limitations of foundation model-based robotics, highlighting open challenges in real-time operation, grounding, resilience, and trust. The review concludes with a roadmap for future research aimed at bridging semantic reasoning and physical intelligence through more robust, interpretable, and embodied models.
Fusing Large Language Models with Temporal Transformers for Time Series Forecasting
Venue: arXiv cs.CL 2025
Year: 2025

Recently, large language models (LLMs) have demonstrated powerful capabilities in performing various tasks and thus are applied by recent studies to time series forecasting (TSF) tasks, which predict future values with the given historical time series. Existing LLM-based approaches transfer knowledge learned from text data to time series prediction using prompting or fine-tuning strategies. However, LLMs are proficient at reasoning over discrete tokens and semantic patterns but are not initially designed to model continuous numerical time series data. The gaps between text and time series data lead LLMs to achieve inferior performance to a vanilla Transformer model that is directly trained on TSF data. However, the vanilla Transformers often struggle to learn high-level semantic patterns. In this paper, we design a novel Transformer-based architecture that complementarily leverages LLMs and vanilla Transformers, so as to integrate the high-level semantic representations learned by LLMs into the temporal information encoded by time series Transformers, where a hybrid representation is obtained by fusing the representations from the LLM and the Transformer. The resulting fused representation contains both historical temporal dynamics and semantic variation patterns, allowing our model to predict more accurate future values. Experiments on benchmark datasets demonstrate the effectiveness of the proposed approach.
When Familiarity Remains: Procedural Memory, Symbolic Anchors, and Digital Engagement in Dementia Care
Venue: arXiv cs.HC 2025
Year: 2025

INTRODUCTION: Older adults with early-stage dementia often retain procedural memory, enabling continued use of familiar technologies. Additionally, symbolic anchors such as photos or personalized content may serve as memory cues to reinforce digital engagement. This study explores how these mechanisms support technology use in dementia care within the South Korean context. METHODS: We conducted in-depth interviews with 11 professional caregivers of community-dwelling older adults with cognitive decline. Grounded theory methods guided the analysis, using iterative coding and constant comparison to identify emergent themes. RESULTS: Caregivers reported that familiar digital routines (e.g., taking photos) persisted through procedural memory. Symbolic anchors such as family photos or recognizable icons enhanced interaction and emotional engagement. However, unfamiliar or anthropomorphic technologies often triggered fear or symbolic resistance. DISCUSSION: Findings highlight the dual role of procedural memory and symbolic anchors in sustaining digital engagement. Designing culturally responsive and cognitively accessible technologies may enhance autonomy and well-being in dementia care. Keywords: procedural memory, symbolic anchors, dementia care, digital engagement, older adults, cultural adaptation, caregiving technologies