OpenRaiser/Intern-Atlas huggingface dataset:
RexDrug: Reliable Multi-Drug Combination Extraction through Reasoning-Enhanced LLMs
Venue: arXiv cs.CL 2026
Year: 2026

Automated Drug Combination Extraction (DCE) from large-scale biomedical literature is crucial for advancing precision medicine and pharmacological research. However, existing relation extraction methods primarily focus on binary interactions and struggle to model variable-length n-ary drug combinations, where complex compatibility logic and distributed evidence need to be considered. To address these limitations, we propose RexDrug, an end-to-end reasoning-enhanced relation extraction framework for n-ary drug combination extraction based on large language models. RexDrug adopts a two-stage training strategy. First, a multi-agent collaborative mechanism is utilized to automatically generate high-quality expert-like reasoning traces for supervised fine-tuning. Second, reinforcement learning with a multi-dimensional reward function specifically tailored for DCE is applied to further refine reasoning quality and extraction accuracy. Extensive experiments on the DrugComb dataset show that RexDrug consistently outperforms state-of-the-art baselines for n-ary extraction. Additional evaluation on the DDI13 corpus confirms its generalizability to binary drugdrug interaction tasks. Human expert assessment and automatic reasoning metrics further indicates that RexDrug produces coherent medical reasoning while accurately identifying complex therapeutic regimens. These results establish RexDrug as a scalable and reliable solution for complex biomedical relation extraction from unstructured text. The source code and data are available at https://github.com/DUTIR-BioNLP/RexDrug
AutoAdapt: An Automated Domain Adaptation Framework for LLMs
Venue: arXiv cs.LG 2026
Year: 2026

Large language models (LLMs) excel in open domains but struggle in specialized settings with limited data and evolving knowledge. Existing domain adaptation practices rely heavily on manual trial-and-error processes, incur significant hyperparameter complexity, and are highly sensitive to data and user preferences, all under the high cost of LLM training. Moreover, the interactions and transferability of hyperparameter choices across models/domains remain poorly understood, making adaptation gains uncertain even with substantial effort. To solve these challenges, we present AutoAdapt, a novel end-to-end automated framework for efficient and reliable LLM domain adaptation. AutoAdapt leverages curated knowledge bases from literature and open-source resources to reduce expert intervention. To narrow the search space, we design a novel multi-agent debating system in which proposal and critic agents iteratively interact to align user intent and incorporate data signals and best practices into the planning process. To optimize hyperparameters under tight budgets, we propose AutoRefine, a novel LLM-based surrogate that replaces costly black-box search. Across 10 tasks, AutoAdapt achieves a 25% average relative accuracy improvement over state-of-the-art Automated Machine Learning baselines with minimal overhead.
SAVE: Speech-Aware Video Representation Learning for Video-Text Retrieval
Venue: arXiv cs.CV 2026
Year: 2026

For video-text retrieval, the use of CLIP has been a de facto choice. Since CLIP provides only image and text encoders, this consensus has led to a biased paradigm that entirely ignores the sound track of videos. While several attempts have been made to reintroduce audio -- typically by incorporating an audio encoder and fusing its output with visual features -- these methods face two challenges: ineffective representation of speech content and suboptimal vision-audio fusion. To address these issues jointly, we propose SAVE, a Speech Aware Video rEpresentation learning method. SAVE improves upon AVIGATE, a SOTA audiovisual method, with a dedicated speech branch for more effective speech embedding. Furthermore, we introduce soft-ALBEF for early vision-audio alignment that facilitates fusion. Extensive experiments on five benchmarks show that SAVE compares favorably against the SOTA, outperforming AVIGATE by +4.1% on MSRVTT-9k, +1.9% on MSRVTT-7k, +2.5% on VATEX, +9.8% on Charades, and +2.1% on LSMDC, in light of the SumR metric.
Practical Type Inference: High-Throughput Recovery of Real-World Structures and Function Signatures
Venue: arXiv cs.CR 2026
Year: 2026

The recovery of types from stripped binaries is a key to exact decompilation, yet its practical realization suffers. For composite structures in particular, both layout and semantic fidelity are required to enable end-to-end reconstruction. Many existing approaches either synthesize layouts or infer names post-hoc, which weakens downstream usability. This is further aggravated by an excessive runtime overhead that is especially prohibitive in automated environments. We present XTRIDE, an improved n-gram-based approach that focuses on practicality: highly optimized throughput and actionable confidence scores allow for deployment in automated pipelines. When compared to the state of the art in struct recovery, our method achieves comparable performance while being between 70 and 2300 times faster. As our inference is grounded in real-world types, we achieve the highest ratio of fully-correct struct layouts. With an optimized training regimen, our model outperforms the current state of the art on the DIRT dataset by 5.09 percentage points, achieving 90.15% type inference accuracy overall. Furthermore, we show that n-gram-based type prediction generalizes to function signature recovery: conducting a case study on embedded firmware, we show that this efficient approach to function similarity can assist in typical reverse engineering tasks.
A General Lie-Group Framework for Continuum Soft Robot Modeling
Venue: arXiv cs.RO 2026
Year: 2026

This paper introduces a general Lie group framework for modeling continuum soft robots, employing Cosserat rod theory combined with cumulative parameterization on the Lie group SE(3). This novel approach addresses limitations present in current strain-based and configuration-based methods by providing geometric local control and eliminating unit quaternion constraints. The paper derives unified analytical expressions for kinematics, statics, and dynamics, including recursive Jacobian computations and an energy-conserving integrator suitable for real-time simulation and control. Additionally, the framework is extended to handle complex robotic structures, including segmented, branched, nested, and rigid-soft composite configurations, facilitating a modular and unified modeling strategy. The effectiveness, generality, and computational efficiency of the proposed methodology are demonstrated through various scenarios, including large-deformation rods, concentric tube robots, parallel robots, cable-driven robots, and articulated fingers. This work enhances modeling flexibility and numerical performance, providing an improved toolset for designing, simulating, and controlling soft robotic systems.
Exploring Deep Learning and Ultra-Widefield Imaging for Diabetic Retinopathy and Macular Edema
Venue: arXiv cs.CV 2026
Year: 2026

Diabetic retinopathy (DR) and diabetic macular edema (DME) are leading causes of preventable blindness among working-age adults. Traditional approaches in the literature focus on standard color fundus photography (CFP) for the detection of these conditions. Nevertheless, recent ultra-widefield imaging (UWF) offers a significantly wider field of view in comparison to CFP. Motivated by this, the present study explores state-of-the-art deep learning (DL) methods and UWF imaging on three clinically relevant tasks: i) image quality assessment for UWF, ii) identification of referable diabetic retinopathy (RDR), and iii) identification of DME. Using the publicly available UWF4DR Challenge dataset, released as part of the MICCAI 2024 conference, we benchmark DL models in the spatial (RGB) and frequency domains, including popular convolutional neural networks (CNNs) as well as recent vision transformers (ViTs) and foundation models. In addition, we explore a final feature-level fusion to increase robustness. Finally, we also analyze the decisions of the DL models using Grad-CAM, increasing the explainability. Our proposal achieves consistently strong performance across all architectures, underscoring the competitiveness of emerging ViTs and foundation models and the promise of feature-level fusion and frequency-domain representations for UWF analysis.
Why Learn What Physics Already Knows? Realizing Agile mmWave-based Human Pose Estimation via Physics-Guided Preprocessing
Venue: arXiv cs.HC 2026
Year: 2026

We revisit millimeter-wave (mmWave) human pose estimation (HPE) from a signal preprocessing perspective. A single mmWave frame provides structured dimensions that map directly to human geometry and motion: range, angle, and Doppler, offering pose-aligned cues that are not explicitly present in RGB images. However, recent mmWave-based HPE systems require more parameters and compute resources yet yield lower estimation accuracy than vision baselines. We attribute this to preprocessing modules: most systems rely on data-driven modules to estimate phenomena that are already well-defined by mmWave sensing physics, whereas human pose could be captured more efficiently with explicit physical priors. To this end, we introduce processing modules that explicitly model mmWave's inter-dimensional correlations and human kinematics. Our design (1) couples range and angle to preserve spatial human structure, (2) leverages Doppler to retain human motion continuity, and (3) applies multi-scale fusion aligned with the human body. A lightweight MLP is involved as the regressor. In experiments, this framework reduces the number of parameters by 55.7-88.9% on the HPE task relative to existing mmWave baselines while maintaining competitive accuracy. Meanwhile, its lightweight nature enables real-time Raspberry Pi deployment. Code and deployment artifacts will be released upon acceptance.
Topologically Stable Hough Transform
Venue: arXiv cs.CG 2026
Year: 2026

We propose an alternative formulation of the well-known Hough transform to detect lines in point clouds. Replacing the discretized voting scheme of the classical Hough transform by a continuous score function, its persistent features in the sense of persistent homology give a set of candidate lines. We also devise and implement an algorithm to efficiently compute these candidate lines.
SAIL: Test-Time Scaling for In-Context Imitation Learning with VLM
Venue: arXiv cs.RO 2026
Year: 2026

In-context imitation learning allows robots to acquire skills from demonstrations, yet one-shot trajectory generation remains fragile under environmental variation. We propose SAIL, a framework that reframes robot imitation as an iterative refinement problem capable of scaling with test-time compute. SAIL utilizes Monte Carlo Tree Search, where each node is a complete trajectory and edges correspond to trajectory refinements. The process is guided by three core components: an automated archive of successful trajectories for contextually relevant retrieval, a vision language model-based scoring mechanism for trajectory evaluation, and a step-level feedback that provides trajectory-aligned scores for iterative refinement. Experiments across six diverse manipulation tasks in simulation and real-world validation clearly demonstrate that increasing test-time compute consistently improves success rates, achieving up to 95% on complex tasks. Our results suggest that trajectory-level test-time scaling is a robust path toward more generalizable robotic agents.
SCL-GNN: Towards Generalizable Graph Neural Networks via Spurious Correlation Learning
Venue: arXiv cs.LG 2026
Year: 2026

Graph Neural Networks (GNNs) have demonstrated remarkable success across diverse tasks. However, their generalization capability is often hindered by spurious correlations between node features and labels in the graph. Our analysis reveals that GNNs tend to exploit imperceptible statistical correlations in training data, even when such correlations are unreliable for prediction. To address this challenge, we propose the Spurious Correlation Learning Graph Neural Network (SCL-GNN), a novel framework designed to enhance generalization on both Independent and Identically Distributed (IID) and Out-of-Distribution (OOD) graphs. SCL-GNN incorporates a principled spurious correlation learning mechanism, leveraging the Hilbert-Schmidt Independence Criterion (HSIC) to quantify correlations between node representations and class scores. This enables the model to identify and mitigate irrelevant but influential spurious correlations effectively. Additionally, we introduce an efficient bi-level optimization strategy to jointly optimize modules and GNN parameters, preventing overfitting. Extensive experiments on real-world and synthetic datasets demonstrate that SCL-GNN consistently outperforms state-of-the-art baselines under various distribution shifts, highlighting its robustness and generalization capabilities.
Less is More: Robust Zero-Communication 3D Pursuit-Evasion via Representational Parsimony
Venue: arXiv cs.RO 2026
Year: 2026

Asymmetric 3D pursuit-evasion in cluttered voxel environments is difficult under communication latency, partial observability, and nonholonomic maneuver limits. While many MARL methods rely on richer inter-agent coupling or centralized signals, these dependencies can become fragility sources when communication is delayed or noisy. Building on an inherited path-guided decentralized pursuit scaffold, we study a robustness-oriented question: can representational parsimony improve communication-free coordination? We instantiate this principle with (i) a parsimonious actor observation interface that removes team-coupled channels (83-D to 50-D), and (ii) Contribution-Gated Credit Assignment (CGCA), a locality-aware credit structure for communication-denied cooperation. In Stage-5 evaluation (4 pursuers vs. 1 evader), our configuration reaches 0.753 +/- 0.091 success and 0.223 +/- 0.066 collision, outperforming the 83-D FULL OBS counterpart (0.721 +/- 0.071, 0.253 +/- 0.089). It further shows graceful degradation under speed/yaw/noise/delay stress tests and resilient zero-shot transfer on urban-canyon maps (about 61% success at density 0.24). These results support a practical paradigm shift: explicitly severing redundant cross-agent channels can suppress compounding error cascades and improve robustness in latency-prone deployment.
AdaCultureSafe: Adaptive Cultural Safety Grounded by Cultural Knowledge in Large Language Models
Venue: arXiv cs.CL 2026
Year: 2026

With the widespread adoption of Large Language Models (LLMs), respecting indigenous cultures becomes essential for models' culturally safety and responsible global applications. Existing studies separately consider cultural safety and cultural knowledge and neglect that the former should be grounded by the latter. This severely prevents LLMs from yielding culture-specific respectful responses. Consequently, adaptive cultural safety remains a formidable task. In this work, we propose to jointly model cultural safety and knowledge. First and foremost, cultural-safety and knowledge-paired data serve as the key prerequisite to conduct this research. However, the cultural diversity across regions and the subtlety of cultural differences pose significant challenges to the creation of such paired evaluation data. To address this issue, we propose a novel framework that integrates authoritative cultural knowledge descriptions curation, LLM-automated query generation, and heavy manual verification. Accordingly, we obtain a dataset named AdaCultureSafe containing 4.8K manually decomposed fine-grained cultural descriptions and the corresponding 48K manually verified safety- and knowledge-oriented queries. Upon the constructed dataset, we evaluate three families of popular LLMs on their cultural safety and knowledge proficiency, via which we make a critical discovery: no significant correlation exists between their cultural safety and knowledge proficiency. We then delve into the utility-related neuron activations within LLMs to investigate the potential cause of the absence of correlation, which can be attributed to the difference of the objectives of pre-training and post-alignment. We finally present a knowledge-grounded method, which significantly enhances cultural safety by enforcing the integration of knowledge into the LLM response generation process.
Evaluating LLM-Based Grant Proposal Review via Structured Perturbations
Venue: arXiv cs.CL 2026
Year: 2026

As AI-assisted grant proposals outpace manual review capacity in a kind of ``Malthusian trap'' for the research ecosystem, this paper investigates the capabilities and limitations of LLM-based grant reviewing for high-stakes evaluation. Using six EPSRC proposals, we develop a perturbation-based framework probing LLM sensitivity across six quality axes: funding, timeline, competency, alignment, clarity, and impact. We compare three review architectures: single-pass review, section-by-section analysis, and a 'Council of Personas' ensemble emulating expert panels. The section-level approach significantly outperforms alternatives in both detection rate and scoring reliability, while the computationally expensive council method performs no better than baseline. Detection varies substantially by perturbation type, with alignment issues readily identified but clarity flaws largely missed by all systems. Human evaluation shows LLM feedback is largely valid but skewed toward compliance checking over holistic assessment. We conclude that current LLMs may provide supplementary value within EPSRC review but exhibit high variability and misaligned review priorities. We release our code and any non-protected data.
SoK: Harmonizing Attack Graphs and Intrusion Detection Systems
Venue: arXiv cs.CR 2026
Year: 2026

Detecting and responding to cyber attacks is increasingly difficult as high-volume, complex network traffic allows threats to remain concealed. While Intrusion Detection Systems (IDSs) identify anomalous behavior, Attack Graphs (AGs) serve as the primary threat model for analyzing attacker strategies and informing any response. Despite the conceptual connection being recognized in early research, the field of AG and IDS integration lacks a common structure. This paper presents the first systematic analysis of AG-IDS integration, reviewing a 73 comprehensive works in literature. We introduce a novel taxonomy revealing that current research is dominated by specialized, single-purpose integrations, such as using AGs to filter IDS false positives or using IDS alerts to prune AGs. Our analysis highlights a critical gap: the absence of a unifying framework that treats IDSs and AGs as a cohesive, integrated system. To address this gap, we propose a formal AG-IDS lifecycle. This framework establishes a continuous feedback loop where IDSs refine the accuracy of AG models, and those updated models, in turn, enhance IDS detection capabilities. We provide a proof-of-concept implementation demonstrating the practical advantages of this lifecycle for threat detection and incident response. Finally, we conclude by elaborating on significant opportunities for future development within the AG-IDS domain.
Do Models See in Line with Human Vision? Probing the Correspondence Between LVLM Representations and EEG Signals
Venue: arXiv cs.HC 2026
Year: 2026

Large Vision Language Models (LVLMs) exhibit strong visual understanding and reasoning abilities. However, whether their internal representations reflect human visual cognition is still under-explored. In this paper, we address this by quantifying LVLM-brain alignment using image-evoked Electroencephalogram (EEG) signals, analyzing the effects of model architecture, scale, and image type. Specifically, by using ridge regression and representational similarity analysis, we compare visual representations from 32 open-source LVLMs with corresponding EEG responses. We observe a structured LVLM-brain correspondence: First, intermediate layers (8-16) show peak alignment with EEG activity in the 100-300 ms window, consistent with hierarchical human visual processing. Secondly, multimodal architectural design contributes 3.4 more to brain alignment than parameter scaling, and models with stronger downstream visual performance exhibit higher EEG similarity. Thirdly, spatiotemporal patterns further align with known cortical visual pathways. These results demonstrate that LVLMs learn human-aligned visual representations and establish neural alignment as a biologically grounded benchmark for evaluating and improving LVLMs. In addition, those results could provide insights that may inform the development of neuro-inspired applications.
Retrieval-Augmented Anatomical Guidance for Text-to-CT Generation
Venue: arXiv cs.CV 2026
Year: 2026

Text-conditioned generative models for volumetric medical imaging provide semantic control but lack explicit anatomical guidance, often resulting in outputs that are spatially ambiguous or anatomically inconsistent. In contrast, structure-driven methods ensure strong anatomical consistency but typically assume access to ground-truth annotations, which are unavailable when the target image is to be synthesized. We propose a retrieval-augmented approach for Text-to-CT generation that integrates semantic and anatomical information under a realistic inference setting. Given a radiology report, our method retrieves a semantically related clinical case using a 3D vision-language encoder and leverages its associated anatomical annotation as a structural proxy. This proxy is injected into a text-conditioned latent diffusion model via a ControlNet branch, providing coarse anatomical guidance while maintaining semantic flexibility. Experiments on the CT-RATE dataset show that retrieval-augmented generation improves image fidelity and clinical consistency compared to text-only baselines, while additionally enabling explicit spatial controllability, a capability inherently absent in such approaches. Further analysis highlights the importance of retrieval quality, with semantically aligned proxies yielding consistent gains across all evaluation axes. This work introduces a principled and scalable mechanism to bridge semantic conditioning and anatomical plausibility in volumetric medical image synthesis. Code will be released.
Concept-Guided Fine-Tuning: Steering ViTs away from Spurious Correlations to Improve Robustness
Venue: arXiv cs.CV 2026
Year: 2026

Vision Transformers (ViTs) often degrade under distribution shifts because they rely on spurious correlations, such as background cues, rather than semantically meaningful features. Existing regularization methods, typically relying on simple foreground-background masks, which fail to capture the fine-grained semantic concepts that define an object (e.g., ``long beak'' and ``wings'' for a ``bird''). As a result, these methods provide limited robustness to distribution shifts. To address this limitation, we introduce a novel finetuning framework that steers model reasoning toward concept-level semantics. Our approach optimizes the model's internal relevance maps to align with spatially grounded concept masks. These masks are generated automatically, without manual annotation: class-relevant concepts are first proposed using an LLM-based, label-free method, and then segmented using a VLM. The finetuning objective aligns relevance with these concept regions while simultaneously suppressing focus on spurious background areas. Notably, this process requires only a minimal set of images and uses half of the dataset classes. Extensive experiments on five out-of-distribution benchmarks demonstrate that our method improves robustness across multiple ViT-based models. Furthermore, we show that the resulting relevance maps exhibit stronger alignment with semantic object parts, offering a scalable path toward more robust and interpretable vision models. Finally, we confirm that concept-guided masks provide more effective supervision for model robustness than conventional segmentation maps, supporting our central hypothesis.