OpenRaiser/Intern-Atlas huggingface dataset:
Central Dogma Transformer II: An AI Microscope for Understanding Cellular Regulatory Mechanisms
Venue: arXiv cs.LG 2026
Year: 2026

Current biological AI models lack interpretability -- their internal representations do not correspond to biological relationships that researchers can examine. Here we present CDT-II, an "AI microscope" whose attention maps are directly interpretable as regulatory structure. By mirroring the central dogma in its architecture, CDT-II ensures that each attention mechanism corresponds to a specific biological relationship: DNA self-attention for genomic relationships, RNA self-attention for gene co-regulation, and DNA-to-RNA cross-attention for transcriptional control. Using only genomic embeddings and raw per-cell expression, CDT-II enables experimental biologists to observe regulatory networks in their own data. Applied to K562 CRISPRi data, CDT-II predicts perturbation effects (per-gene mean $r = 0.84$) and recovers the GFI1B regulatory network without supervision (6.6-fold enrichment, $P = 3.5 \times 10^{-17}$). Systematic comparison against ENCODE K562 regulatory annotations reveals that cross-attention autonomously focuses on known regulatory elements -- DNase hypersensitive sites ($201\times$ enrichment), CTCF binding sites ($28\times$), and histone marks -- across all five held-out genes. Two distinct attention mechanisms independently identify an overlapping RNA processing module (80% gene overlap; RNA binding enrichment $P = 1 \times 10^{-16}$). CDT-II establishes mechanism-oriented AI as an alternative to task-oriented approaches, revealing regulatory structure rather than merely optimizing predictions.
VedicTHG: Symbolic Vedic Computation for Low-Resource Talking-Head Generation in Educational Avatars
Venue: arXiv cs.CV 2026
Year: 2026

Talking-head avatars are increasingly adopted in educational technology to deliver content with social presence and improved engagement. However, many recent talking-head generation (THG) methods rely on GPU-centric neural rendering, large training sets, or high-capacity diffusion models, which limits deployment in offline or resource-constrained learning environments. A deterministic and CPU-oriented THG framework is described, termed Symbolic Vedic Computation, that converts speech to a time-aligned phoneme stream, maps phonemes to a compact viseme inventory, and produces smooth viseme trajectories through symbolic coarticulation inspired by Vedic sutra Urdhva Tiryakbhyam. A lightweight 2D renderer performs region-of-interest (ROI) warping and mouth compositing with stabilization to support real-time synthesis on commodity CPUs. Experiments report synchronization accuracy, temporal stability, and identity consistency under CPU-only execution, alongside benchmarking against representative CPU-feasible baselines. Results indicate that acceptable lip-sync quality can be achieved while substantially reducing computational load and latency, supporting practical educational avatars on low-end hardware. GitHub: https://vineetkumarrakesh.github.io/vedicthg
Addressing data annotation scarcity in Brain Tumor Segmentation on 3D MRI scan Using a Semi-Supervised Teacher-Student Framework
Venue: arXiv cs.CV 2026
Year: 2026

Accurate brain tumor segmentation from MRI is limited by expensive annotations and data heterogeneity across scanners and sites. We propose a semi-supervised teacher-student framework that combines an uncertainty-aware pseudo-labeling teacher with a progressive, confidence-based curriculum for the student. The teacher produces probabilistic masks and per-pixel uncertainty; unlabeled scans are ranked by image-level confidence and introduced in stages, while a dual-loss objective trains the student to learn from high-confidence regions and unlearn low-confidence ones. Agreement-based refinement further improves pseudo-label quality. On BraTS 2021, validation DSC increased from 0.393 (10% data) to 0.872 (100%), with the largest gains in early stages, demonstrating data efficiency. The teacher reached a validation DSC of 0.922, and the student surpassed the teacher on tumor subregions (e.g., NCR/NET 0.797 and Edema 0.980); notably, the student recovered the Enhancing class (DSC 0.620) where the teacher failed. These results show that confidence-driven curricula and selective unlearning provide robust segmentation under limited supervision and noisy pseudo-labels.
Equilibria: Fair Multi-Tenant CXL Memory Tiering At Scale
Venue: arXiv cs.OS 2026
Year: 2026

Memory dominates datacenter system cost and power. Memory expansion via Compute Express Link (CXL) is an effective way to provide additional memory at lower cost and power, but its effective use requires software-level tiering for hyperscaler workloads. Existing tiering solutions, including current Linux support, face fundamental limitations in production deployments. First, they lack multi-tenancy support, failing to handle stacked homogeneous or heterogeneous workloads. Second, limited control-plane flexibility leads to fairness violations and performance variability. Finally, insufficient observability prevents operators from diagnosing performance pathologies at scale. We present Equilibria, an OS framework enabling fair, multi-tenant CXL tiering at datacenter scale. Equilibria provides per-container controls for memory fair-share allocation and fine-grained observability of tiered-memory usage and operations. It further enforces flexible, user-specified fairness policies through regulated promotion and demotion, and mitigates noisy-neighbor interference by suppressing thrashing. Evaluated in a large hyperscaler fleet using production workloads and benchmarks, Equilibria helps workloads meet service level objectives (SLOs) while avoiding performance interference. It improves performance over the state-of-the-art Linux solution, TPP, by up to 52% for production workloads and 1.7x for benchmarks. All Equilibria patches have been released to the Linux community.
How2Everything: Mining the Web for How-To Procedures to Evaluate and Improve LLMs
Venue: arXiv cs.LG 2026
Year: 2026

Generating step-by-step "how-to" procedures is a key LLM capability: how-to advice is commonly requested in chatbots, and step-by-step planning is critical for reasoning over complex tasks. Yet, measuring and improving procedural validity at scale on real-world tasks remains challenging and understudied. To address this, we introduce How2Everything, a scalable framework to evaluate and improve goal-conditioned procedure generation. Our framework includes How2Mine, which mines 351K procedures from 980K web pages across 14 topics and readily scales to larger corpora. From this pool we build How2Bench, a 7K-example evaluation set balanced across topics. To reliably score model outputs, we develop How2Score, an evaluation protocol that uses an LLM judge to detect whether a generation contains any critical failure that would prevent achieving the goal. For low-cost, reproducible evaluation, we distill a frontier model into an open 8B model, achieving 80.5% agreement with human annotators. How2Bench reveals clear scaling trends across model sizes and training stages, providing signal early in pretraining. Finally, RL using How2Score as a reward improves performance on How2Bench by >10 points across three models without systematic regressions on standard benchmarks, with gains robust to superficial source-document memorization or format compliance. Taken together, How2Everything shows how pretraining web data can support a closed loop of capability evaluation and improvement at scale.
Kirin: Improving ANN efficiency with SNN Hybridization
Venue: arXiv cs.LG 2026
Year: 2026

Artificial neural networks (ANNs), particularly large language models (LLMs), demonstrate powerful inference capabilities but consume substantial energy. Conversely, spiking neural networks (SNNs) exhibit exceptional energy efficiency due to their binary and event-driven characteristics, thus motivating the study of ANN-to-SNN conversion. In this process, quantization plays a pivotal role, mapping LLMs' floating-point parameters to discrete SNN parameters via the temporal dimension of the time window. However, several challenges remain in the conversion process: (i) converting high bit-width quantization values into binary spikes requires longer time windows, increasing system latency; and (ii) the inherent trade-off between the information loss of single-spike schemes and the energy costs of multi-spike ones in SNN. To address these challenges, we propose Kirin, a integer and spike hybrid based SNN to achieve accuracy lossless ANN-to-SNN conversion with time and energy efficiency. Specifically, we first propose a Spike Matrix Hybridization strategy that encoding low bit-width parameters that leading to small time window size into binary spikes while preserving the rest in integer format, thereby reducing the overall latency of SNN execution. Second, we introduce a silence threshold mechanism to regulate the timing of single-spike firing, ensuring the output is mathematically equivalent to the LLM's output and preserves accuracy. Experimental results demonstrate that Kirin, under a W4A4\&8 quantization setting, achieves near-FP16 accuracy while reducing energy consumption by up to 84.66\% and shortening time steps by 93.75\%.
Bayesian Preference Learning for Test-Time Steerable Reward Models
Venue: arXiv cs.LG 2026
Year: 2026

Reward models are central to aligning language models with human preferences via reinforcement learning (RL). As RL is increasingly applied to settings such as verifiable rewards and multi-objective alignment, RMs are expected to encode more complex and multifaceted preference distributions. However, classifier RMs remain static once trained, limiting their adaptability at test time. We propose Variational In-Context Reward Modeling (ICRM), a novel Bayesian reward modeling objective that enables test-time steerability via in-context preference demonstrations. ICRM casts reward modeling as amortized variational inference over a latent preference probability under the Bradley-Terry model using a conjugate Beta prior. We show that ICRM adapt to unseen preference distributions at test time for both single and multi-objective settings. With more in-context demonstrations, ICRM gains 34% accuracy on SafeRLHF and 9% accuracy on RM-Bench in the single-objective setting, while widening the Pareto frontier with a 4% gain in hypervolume on helpfulness and refusal benchmarks. We further study the practical applicability of ICRM for RL training, showing that it can effectively encode verifiable rewards by outperforming a conventional RM in math reasoning. Finally, we provide theoretical guarantees that the variational objective admits a global interior optimum with finite confidence, and we analyze how KL regularization mitigates reward over-optimization.
Any-to-All MRI Synthesis: A Unified Foundation Model for Nasopharyngeal Carcinoma and Its Downstream Applications
Venue: arXiv cs.CV 2026
Year: 2026

Magnetic resonance imaging (MRI) is essential for nasopharyngeal carcinoma (NPC) radiotherapy (RT), but practical constraints, such as patient discomfort, long scan times, and high costs often lead to incomplete modalities in clinical practice, compromising RT planning accuracy. Traditional MRI synthesis methods are modality-specific, limited in anatomical adaptability, and lack clinical interpretability-failing to meet NPC's RT needs. Here, we developed a unified foundation model integrating contrastive visual representation learning and vision-language alignment (VLA) to enable any-to-all MRI synthesis. The model uses a contrastive encoder for modality-invariant representations and a CLIP-based text-informed decoder for semantically consistent synthesis, supporting any-to-all MRI synthesis via one unified foundation model. Trained on 40,825 images from 13 institutions, it achieves consistently high performance (average SSIM 0.90, PSNR 27) across 26 internal/external validation sites (15,748 images), with superior synthesis fidelity and robustness to noise and domain shifts. Meanwhile, its unified representation enhances downstream RT-relevant tasks (e.g., segmentation). This work advances digital medicine solutions for NPC care by leveraging foundation models to bridge technical synthesis and clinical utility.
Affective Flow Language Model for Emotional Support Conversation
Venue: arXiv cs.CL 2026
Year: 2026

Large language models (LLMs) have been widely applied to emotional support conversation (ESC). However, complex multi-turn support remains challenging.This is because existing alignment schemes rely on sparse outcome-level signals, thus offering limited supervision for intermediate strategy decisions. To fill this gap, this paper proposes affective flow language model for emotional support conversation (AFlow), a framework that introduces fine-grained supervision on dialogue prefixes by modeling a continuous affective flow along multi-turn trajectories. AFlow can estimate intermediate utility over searched trajectories and learn preference-consistent strategy transitions. To improve strategy coherence and empathetic response quality, a subpath-level flow-balance objective is presented to propagate preference signals to intermediate states. Experiment results show consistent and significant improvements over competitive baselines in diverse emotional contexts. Remarkably, AFlow with a compact open-source backbone outperforms proprietary LMMs such as GPT-4o and Claude-3.5 on major ESC metrics. Our code is available at https://github.com/chzou25-lgtm/AffectiveFlow.
Enhancing Generative AI Image Refinement with Scribbles and Annotations: A Comparative Study of Multimodal Prompts
Venue: arXiv cs.HC 2026
Year: 2026

Generative AI (GenAI) image tools are increasingly used in design practice, enabling rapid ideation but offering limited support for refinement tasks such as adjusting layout, scale, or visual attributes. While text prompts and inpainting allow localized edits, they often remain inefficient or ambiguous for precise, in-context, and iterative refinement -- motivating the exploration of alternative methods. This work examines how pen-based scribbles and annotations can enhance GenAI image refinement. A formative study with seven professional designers informed a prototype supporting three input modalities: text-only, visual-only, and combined prompting. A within-subjects study with 30 designers and design students compared these modalities across closed- and open-ended tasks, evaluating expressiveness, efficiency, workload, user experience, iteration, and multimodal strategies. Visual prompts improved clarity and speed for spatial edits while reducing workload, whereas text remained effective for semantic and global changes. The combined modality received the highest overall ratings, enabling complementary use, balancing spatial precision with semantic detail, and supporting smoother iteration. Task-specific preferences also emerged: adding new objects often required both modalities, while moving or modifying elements was typically handled through visual input. This work contributes (1) an empirical comparison of multimodal prompting for GenAI refinement, (2) a prototype integrating scribbles and annotations, and (3) insights into designers' multimodal strategies to inform future GenAI interfaces that better support refinement in GenAI-supported design workflows.
karl. - A Research Vehicle for Automated and Connected Driving
Venue: arXiv cs.AR 2026
Year: 2026

As highly automated driving is transitioning from single-vehicle closed-access testing to commercial deployments of public ride-hailing in selected areas (e.g., Waymo), automated driving and connected cooperative intelligent transport systems (C-ITS) remain active fields of research. Even though simulation is omnipresent in the development and validation life cycle of automated and connected driving technology, the complex nature of public road traffic and software that masters it still requires real-world integration and testing with actual vehicles. Dedicated vehicles for research and development allow testing and validation of software and hardware components under real-world conditions early on. They also enable collecting and publishing real-world datasets that let others conduct research without vehicle access, and support early demonstration of futuristic use cases. In this paper, we present karl., our new research vehicle for automated and connected driving. Apart from major corporations, few institutions worldwide have access to their own L4-capable research vehicles, restricting their ability to carry out independent research. This paper aims to help bridge that gap by sharing the reasoning, design choices, and technical details that went into making karl. a flexible and powerful platform for research, engineering, and validation in the context of automated and connected driving. More impressions of karl. are available at https://karl.ac.
FlattenGPT: Depth Compression for Transformer with Layer Flattening
Venue: arXiv cs.CV 2026
Year: 2026

Recent works have indicated redundancy across transformer blocks, prompting the research of depth compression to prune less crucial blocks. However, current ways of entire-block pruning suffer from risks of discarding meaningful cues learned in those blocks, leading to substantial performance degradation. As another line of model compression, channel pruning can better preserve performance, while it cannot reduce model depth and is challenged by inconsistent pruning ratios for individual layers. To pursue better model compression and acceleration, this paper proposes \textbf{FlattenGPT}, a novel way to detect and reduce depth-wise redundancies. By flatting two adjacent blocks into one, it compresses the network depth, meanwhile enables more effective parameter redundancy detection and removal. FlattenGPT allows to preserve the knowledge learned in all blocks, and remains consistent with the original transformer architecture. Extensive experiments demonstrate that FlattenGPT enhances model efficiency with a decent trade-off to performance. It outperforms existing pruning methods in both zero-shot accuracies and WikiText-2 perplexity across various model types and parameter sizes. On LLaMA-2/3 and Qwen-1.5 models, FlattenGPT retains 90-96\% of zero-shot performance with a compression ratio of 20\%. It also outperforms other pruning methods in accelerating LLM inference, making it promising for enhancing the efficiency of transformers.
Magnitude Distance: A Geometric Measure of Dataset Similarity
Venue: arXiv cs.LG 2026
Year: 2026

Quantifying the distance between datasets is a fundamental question in mathematics and machine learning. We propose \textit{magnitude distance}, a novel distance metric defined on finite datasets using the notion of the \emph{magnitude} of a metric space. The proposed distance incorporates a tunable scaling parameter, $t$, that controls the sensitivity to global structure (small $t$) and finer details (large $t$). We prove several theoretical properties of magnitude distance, including its limiting behavior across scales and conditions under which it satisfies key metric properties. In contrast to classical distances, we show that magnitude distance remains discriminative in high-dimensional settings when the scale is appropriately tuned. We further demonstrate how magnitude distance can be used as a training objective for push-forward generative models. Our experimental results support our theoretical analysis and demonstrate that magnitude distance provides meaningful signals, comparable to established distance-based generative approaches.
Near-optimal Swap Regret Minimization for Convex Losses
Venue: arXiv cs.LG 2026
Year: 2026

We give a randomized online algorithm that guarantees near-optimal $\widetilde O(\sqrt T)$ expected swap regret against any sequence of $T$ adaptively chosen Lipschitz convex losses on the unit interval. This improves the previous best bound of $\widetilde O(T^{2/3})$ and answers an open question of Fishelson et al. [2025b]. In addition, our algorithm is efficient: it runs in $\mathsf{poly}(T)$ time. A key technical idea we develop to obtain this result is to discretize the unit interval into bins at multiple scales of granularity and simultaneously use all scales to make randomized predictions, which we call multi-scale binning and may be of independent interest. A direct corollary of our result is an efficient online algorithm for minimizing the calibration error for general elicitable properties. This result does not require the Lipschitzness assumption of the identification function needed in prior work, making it applicable to median calibration, for which we achieve the first $\widetilde O(\sqrt T)$ calibration error guarantee.
ZK-Rollup for Hyperledger Fabric: Architecture and Performance Evaluation
Venue: arXiv cs.CR 2026
Year: 2026

A big challenge posed in blockchain centric platforms is achieving scalability while also preserving user privacy. This report details the design, implementation and evaluation of a Layer-2 scaling solution for Hyperledger Fabric using Zero Knowledge Rollups (ZK Rollups). The proposed architecture introduces an off chain sequencer that accepts transactions immediately and sends them for batching into a Merkle tree based rollup, using ZK proofs to attest to the correctness and verifiability of the entire batch. The design aims to decouple transaction ingestion from actual on chain settlements to address Fabric scalability limitations and increase throughput under high load conditions. The baseline architecture in Hyperledger Fabric constrains transaction requests due to endorsement, ordering and validation phases, leading to a throughput of 5 to 7 TPS with an average latency of 4 seconds. Our Layer-2 solution achieves an ingestion throughput of 70 to 100 TPS, leading to an increase of nearly ten times due to the sequencer immediate acceptance of each transaction and reducing client perceived latency by nearly eighty percent to 700 to 1000 milliseconds. This work demonstrates that integrating ZK Rollups in Hyperledger Fabric enhances scalability while not compromising the security guarantees of a permissioned blockchain network.
Scalable Delphi: Large Language Models for Structured Risk Estimation
Venue: arXiv cs.AI 2026
Year: 2026

Quantitative risk assessment in high-stakes domains relies on structured expert elicitation to estimate unobservable properties. The gold standard - the Delphi method - produces calibrated, auditable judgments but requires months of coordination and specialist time, placing rigorous risk assessment out of reach for most applications. We investigate whether Large Language Models (LLMs) can serve as scalable proxies for structured expert elicitation. We propose Scalable Delphi, adapting the classical protocol for LLMs with diverse expert personas, iterative refinement, and rationale sharing. Because target quantities are typically unobservable, we develop an evaluation framework based on necessary conditions: calibration against verifiable proxies, sensitivity to evidence, and alignment with human expert judgment. We evaluate in the domain of AI-augmented cybersecurity risk, using three capability benchmarks and independent human elicitation studies. LLM panels achieve strong correlations with benchmark ground truth (Pearson r=0.87-0.95), improve systematically as evidence is added, and align with human expert panels - in one comparison, closer to a human panel than the two human panels are to each other. This demonstrates that LLM-based elicitation can extend structured expert judgment to settings where traditional methods are infeasible, reducing elicitation time from months to minutes.