OpenRaiser/Intern-Atlas huggingface dataset:
Measuring AI Progress in Drug Discovery: A Reproducible Leaderboard for the Tox21 Challenge
Venue: arXiv cs.LG 2025
Year: 2025

Deep learning's rise since the early 2010s has transformed fields like computer vision and natural language processing and strongly influenced biomedical research. For drug discovery specifically, a key inflection - akin to vision's "ImageNet moment" - arrived in 2015, when deep neural networks surpassed traditional approaches on the Tox21 Data Challenge. This milestone accelerated the adoption of deep learning across the pharmaceutical industry, and today most major companies have integrated these methods into their research pipelines. After the Tox21 Challenge concluded, its dataset was included in several established benchmarks, such as MoleculeNet and the Open Graph Benchmark. However, during these integrations, the dataset was altered and labels were imputed or manufactured, resulting in a loss of comparability across studies. Consequently, the extent to which bioactivity and toxicity prediction methods have improved over the past decade remains unclear. To this end, we introduce a reproducible leaderboard, hosted on Hugging Face with the original Tox21 Challenge dataset, together with a set of baseline and representative methods. The current version of the leaderboard indicates that the original Tox21 winner - the ensemble-based DeepTox method - and the descriptor-based self-normalizing neural networks introduced in 2017, continue to perform competitively and rank among the top methods for toxicity prediction, leaving it unclear whether substantial progress in toxicity prediction has been achieved over the past decade. As part of this work, we make all baselines and evaluated models publicly accessible for inference via standardized API calls to Hugging Face Spaces.
Vision Large Language Models Are Good Noise Handlers in Engagement Analysis
Venue: arXiv cs.CV 2025
Year: 2025

Engagement recognition in video datasets, unlike traditional image classification tasks, is particularly challenged by subjective labels and noise limiting model performance. To overcome the challenges of subjective and noisy engagement labels, we propose a framework leveraging Vision Large Language Models (VLMs) to refine annotations and guide the training process. Our framework uses a questionnaire to extract behavioral cues and split data into high- and low-reliability subsets. We also introduce a training strategy combining curriculum learning with soft label refinement, gradually incorporating ambiguous samples while adjusting supervision to reflect uncertainty. We demonstrate that classical computer vision models trained on refined high-reliability subsets and enhanced with our curriculum strategy show improvements, highlighting benefits of addressing label subjectivity with VLMs. This method surpasses prior state of the art across engagement benchmarks such as EngageNet (three of six feature settings, maximum improvement of +1.21%), and DREAMS / PAFE with F1 gains of +0.22 / +0.06.
Robust Verification of Controllers under State Uncertainty via Hamilton-Jacobi Reachability Analysis
Venue: arXiv cs.RO 2025
Year: 2025

As perception-based controllers for autonomous systems become increasingly popular in the real world, it is important that we can formally verify their safety and performance despite perceptual uncertainty. Unfortunately, the verification of such systems remains challenging, largely due to the complexity of the controllers, which are often nonlinear, nonconvex, learning-based, and/or black-box. Prior works propose verification algorithms that are based on approximate reachability methods, but they often restrict the class of controllers and systems that can be handled or result in overly conservative analyses. Hamilton-Jacobi (HJ) reachability analysis is a popular formal verification tool for general nonlinear systems that can compute optimal reachable sets under worst-case system uncertainties; however, its application to perception-based systems is currently underexplored. In this work, we propose RoVer-CoRe, a framework for the Robust Verification of Controllers via HJ Reachability. To the best of our knowledge, RoVer-CoRe is the first HJ reachability-based framework for the verification of perception-based systems under perceptual uncertainty. Our key insight is to concatenate the system controller, observation function, and the state estimation modules to obtain an equivalent closed-loop system that is readily compatible with existing reachability frameworks. Within RoVer-CoRe, we propose novel methods for formal safety verification and robust controller design. We demonstrate the efficacy of the framework in case studies involving aircraft taxiing and NN-based rover navigation. Code is available at the link in the footnote.
NeuCLIRBench: A Modern Evaluation Collection for Monolingual, Cross-Language, and Multilingual Information Retrieval
Venue: arXiv cs.IR 2025
Year: 2025

To measure advances in retrieval, test collections with relevance judgments that can faithfully distinguish systems are required. This paper presents NeuCLIRBench, an evaluation collection for cross-language and multilingual retrieval. The collection consists of documents written natively in Chinese, Persian, and Russian, as well as those same documents machine translated into English. The collection supports several retrieval scenarios including: monolingual retrieval in English, Chinese, Persian, or Russian; cross-language retrieval with English as the query language and one of the other three languages as the document language; and multilingual retrieval, again with English as the query language and relevant documents in all three languages. NeuCLIRBench combines the TREC NeuCLIR track topics of 2022, 2023, and 2024. The 250,128 judgments across approximately 150 queries for the monolingual and cross-language tasks and 100 queries for multilingual retrieval provide strong statistical discriminatory power to distinguish retrieval approaches. A fusion baseline of strong neural retrieval systems is included with the collection so that developers of reranking algorithms are no longer reliant on BM25 as their first-stage retriever. NeuCLIRBench is publicly available.
An LLM-Powered Agent for Real-Time Analysis of the Vietnamese IT Job Market
Venue: arXiv cs.IR 2025
Year: 2025

Individuals entering Vietnam's dynamic Information Technology (IT) job market face a critical gap in reliable career guidance. Existing market reports are often outdated, while the manual analysis of thousands of job postings is impractical for most. To address this challenge, we present the AI Job Market Consultant, a novel conversational agent that delivers deep, data-driven insights directly from the labor market in real-time. The foundation of our system is a custom-built dataset created via an automated pipeline that crawls job portals using Playwright and leverages the Large Language Model (LLM) to intelligently structure unstructured posting data. The core of our system is a tool-augmented AI agent, based on the ReAct agentic framework, which enables the ability of autonomously reasoning, planning, and executing actions through a specialized toolbox for SQL queries, semantic search, and data visualization. Our prototype successfully collected and analyzed 3,745 job postings, demonstrating its ability to answer complex, multi-step queries, generate on-demand visualizations, and provide personalized career advice grounded in real-world data. This work introduces a new paradigm for labor market analysis, showcasing how specialized agentic AI systems can democratize access to timely, trustworthy career intelligence for the next generation of professionals.
Subnational Geocoding of Global Disasters Using Large Language Models
Venue: arXiv cs.AI 2025
Year: 2025

Subnational location data of disaster events are critical for risk assessment and disaster risk reduction. Disaster databases such as EM-DAT often report locations in unstructured textual form, with inconsistent granularity or spelling, that make it difficult to integrate with spatial datasets. We present a fully automated LLM-assisted workflow that processes and cleans textual location information using GPT-4o, and assigns geometries by cross-checking three independent geoinformation repositories: GADM, OpenStreetMap and Wikidata. Based on the agreement and availability of these sources, we assign a reliability score to each location while generating subnational geometries. Applied to the EM-DAT dataset from 2000 to 2024, the workflow geocodes 14,215 events across 17,948 unique locations. Unlike previous methods, our approach requires no manual intervention, covers all disaster types, enables cross-verification across multiple sources, and allows flexible remapping to preferred frameworks. Beyond the dataset, we demonstrate the potential of LLMs to extract and structure geographic information from unstructured text, offering a scalable and reliable method for related analyses.
IHearYou: Linking Acoustic Features to DSM-5 Depressive Behavior Indicators
Venue: arXiv cs.SD 2025
Year: 2025

Depression affects over millions people worldwide, yet diagnosis still relies on subjective self-reports and interviews that may not capture authentic behavior. We present IHearYou, an approach to automated depression detection focused on speech acoustics. Using passive sensing in household environments, IHearYou extracts voice features and links them to DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) indicators through a structured Linkage Framework instantiated for Major Depressive Disorder. The system runs locally to preserve privacy and includes a persistence schema and dashboard, presenting real-time throughput on a commodity laptop. To ensure reproducibility, we define a configuration-driven protocol with False Discovery Rate (FDR) correction and gender-stratified testing. Applied to the DAIC-WOZ dataset, this protocol reveals directionally consistent feature-indicator associations, while a TESS-based audio streaming experiment validates end-to-end feasibility. Our results show how passive voice sensing can be turned into explainable DSM-5 indicator scores, bridging the gap between black-box detection and clinically interpretable, on-device analysis.
Empowering Multi-Turn Tool-Integrated Reasoning with Group Turn Policy Optimization
Venue: arXiv cs.LG 2025
Year: 2025

Training Large Language Models (LLMs) for multi-turn Tool-Integrated Reasoning (TIR) - where models iteratively reason, generate code, and verify through execution - remains challenging for existing reinforcement learning (RL) approaches. Current RL methods, exemplified by Group Relative Policy Optimization (GRPO), suffer from coarse-grained, trajectory-level rewards that provide insufficient learning signals for complex multi-turn interactions, leading to training stagnation. To address this issue, we propose Group Turn Policy Optimization (GTPO), a novel RL algorithm specifically designed for training LLMs on multi-turn TIR tasks. GTPO introduces three key innovations: (1) turn-level reward assignment that provides fine-grained feedback for individual turns, (2) return-based advantage estimation where normalized discounted returns are calculated as advantages, and (3) self-supervised reward shaping that exploits self-supervision signals from generated code to densify sparse binary outcome-based rewards. Our comprehensive evaluation demonstrates that GTPO outperforms GRPO by 3.0% on average across diverse reasoning benchmarks, establishing its effectiveness for advancing complex mathematical reasoning in the real world.
Exact Learning of Weighted Graphs Using Composite Queries
Venue: arXiv cs.DS 2025
Year: 2025

In this paper, we study the exact learning problem for weighted graphs, where we are given the vertex set, $V$, of a weighted graph, $G=(V,E,w)$, but we are not given $E$. The problem, which is also known as graph reconstruction, is to determine all the edges of $E$, including their weights, by asking queries about $G$ from an oracle. As we observe, using simple shortest-path length queries is not sufficient, in general, to learn a weighted graph. So we study a number of scenarios where it is possible to learn $G$ using a subquadratic number of composite queries, which combine two or three simple queries.
InstructMix2Mix: Consistent Sparse-View Editing Through Multi-View Model Personalization
Venue: arXiv cs.CV 2025
Year: 2025

We address the task of multi-view image editing from sparse input views, where the inputs can be seen as a mix of images capturing the scene from different viewpoints. The goal is to modify the scene according to a textual instruction while preserving consistency across all views. Existing methods, based on per-scene neural fields or temporal attention mechanisms, struggle in this setting, often producing artifacts and incoherent edits. We propose InstructMix2Mix (I-Mix2Mix), a framework that distills the editing capabilities of a 2D diffusion model into a pretrained multi-view diffusion model, leveraging its data-driven 3D prior for cross-view consistency. A key contribution is replacing the conventional neural field consolidator in Score Distillation Sampling (SDS) with a multi-view diffusion student, which requires novel adaptations: incremental student updates across timesteps, a specialized teacher noise scheduler to prevent degeneration, and an attention modification that enhances cross-view coherence without additional cost. Experiments demonstrate that I-Mix2Mix significantly improves multi-view consistency while maintaining high per-frame edit quality.
FarSLIP: Discovering Effective CLIP Adaptation for Fine-Grained Remote Sensing Understanding
Venue: arXiv cs.CV 2025
Year: 2025

As CLIP's global alignment limits its ability to capture fine-grained details, recent efforts have focused on enhancing its region-text alignment. However, current remote sensing (RS)-specific CLIP variants still inherit this limited spatial awareness. We identify two key limitations behind this: (1) current RS image-text datasets generate global captions from object-level labels, leaving the original object-level supervision underutilized; (2) despite the success of region-text alignment methods in general domain, their direct application to RS data often leads to performance degradation. To address these, we construct the first multi-granularity RS image-text dataset, MGRS-200k, featuring rich object-level textual supervision for RS region-category alignment. We further investigate existing fine-grained CLIP tuning strategies and find that current explicit region-text alignment methods, whether in a direct or indirect way, underperform due to severe degradation of CLIP's semantic coherence. Building on these, we propose FarSLIP, a Fine-grained Aligned RS Language-Image Pretraining framework. Rather than the commonly used patch-to-CLS self-distillation, FarSLIP employs patch-to-patch distillation to align local and global visual cues, which improves feature discriminability while preserving semantic coherence. Additionally, to effectively utilize region-text supervision, it employs simple CLS token-based region-category alignment rather than explicit patch-level alignment, further enhancing spatial awareness. FarSLIP features improved fine-grained vision-language alignment in RS domain and sets a new state of the art not only on RS open-vocabulary semantic segmentation, but also on image-level tasks such as zero-shot classification and image-text retrieval. Our dataset, code, and models are available at https://github.com/NJU-LHRS/FarSLIP.
CPSL: Representing Volumetric Video via Content-Promoted Scene Layers
Venue: arXiv cs.CV 2025
Year: 2025

Volumetric video enables immersive and interactive visual experiences by supporting free viewpoint exploration and realistic motion parallax. However, existing volumetric representations from explicit point clouds to implicit neural fields, remain costly in capture, computation, and rendering, which limits their scalability for on-demand video and reduces their feasibility for real-time communication. To bridge this gap, we propose Content-Promoted Scene Layers (CPSL), a compact 2.5D video representation that brings the perceptual benefits of volumetric video to conventional 2D content. Guided by per-frame depth and content saliency, CPSL decomposes each frame into a small set of geometry-consistent layers equipped with soft alpha bands and an edge-depth cache that jointly preserve occlusion ordering and boundary continuity. These lightweight, 2D-encodable assets enable parallax-corrected novel-view synthesis via depth-weighted warping and front-to-back alpha compositing, bypassing expensive 3D reconstruction. Temporally, CPSL maintains inter-frame coherence using motion-guided propagation and per-layer encoding, supporting real-time playback with standard video codecs. Across multiple benchmarks, CPSL achieves superior perceptual quality and boundary fidelity compared with layer-based and neural-field baselines while reducing storage and rendering cost by several folds. Our approach offer a practical path from 2D video to scalable 2.5D immersive media.
Fine-tuning Pre-trained Audio Models for COVID-19 Detection: A Technical Report
Venue: arXiv cs.SD 2025
Year: 2025

This technical report investigates the performance of pre-trained audio models on COVID-19 detection tasks using established benchmark datasets. We fine-tuned Audio-MAE and three PANN architectures (CNN6, CNN10, CNN14) on the Coswara and COUGHVID datasets, evaluating both intra-dataset and cross-dataset generalization. We implemented a strict demographic stratification by age and gender to prevent models from exploiting spurious correlations between demographic characteristics and COVID-19 status. Intra-dataset results showed moderate performance, with Audio-MAE achieving the strongest result on Coswara (0.82 AUC, 0.76 F1-score), while all models demonstrated limited performance on Coughvid (AUC 0.58-0.63). Cross-dataset evaluation revealed severe generalization failure across all models (AUC 0.43-0.68), with Audio-MAE showing strong performance degradation (F1-score 0.00-0.08). Our experiments demonstrate that demographic balancing, while reducing apparent model performance, provides more realistic assessment of COVID-19 detection capabilities by eliminating demographic leakage - a confounding factor that inflate performance metrics. Additionally, the limited dataset sizes after balancing (1,219-2,160 samples) proved insufficient for deep learning models that typically require substantially larger training sets. These findings highlight fundamental challenges in developing generalizable audio-based COVID-19 detection systems and underscore the importance of rigorous demographic controls for clinically robust model evaluation.
SVBRD-LLM: Self-Verifying Behavioral Rule Discovery for Autonomous Vehicle Identification
Venue: arXiv cs.RO 2025
Year: 2025

As more autonomous vehicles operate on public roads, understanding real-world behavior of autonomous vehicles is critical to analyzing traffic safety, making policies, and public acceptance. This paper proposes SVBRD-LLM, a framework that automatically discovers, verifies, and applies interpretable behavioral rules from real traffic videos through zero-shot prompt engineering. The framework extracts vehicle trajectories using YOLOv8 and ByteTrack, computes kinematic features, and employs GPT-5 zero-shot prompting to compare autonomous and human-driven vehicles, generating 35 structured behavioral rule hypotheses. These rules are tested on a validation set, iteratively refined based on failure cases to filter spurious correlations, and compiled into a high-confidence rule library. The framework is evaluated on an independent test set for speed change prediction, lane change prediction, and autonomous vehicle identification tasks. Experiments on over 1500 hours of real traffic videos show that the framework achieves 90.0% accuracy and 93.3% F1-score in autonomous vehicle identification. The discovered rules clearly reveal distinctive characteristics of autonomous vehicles in speed control smoothness, lane change conservativeness, and acceleration stability, with each rule accompanied by semantic description, applicable context, and validation confidence.
Kandinsky 5.0: A Family of Foundation Models for Image and Video Generation
Venue: arXiv cs.CV 2025
Year: 2025

This report introduces Kandinsky 5.0, a family of state-of-the-art foundation models for high-resolution image and 10-second video synthesis. The framework comprises three core line-up of models: Kandinsky 5.0 Image Lite - a line-up of 6B parameter image generation models, Kandinsky 5.0 Video Lite - a fast and lightweight 2B parameter text-to-video and image-to-video models, and Kandinsky 5.0 Video Pro - 19B parameter models that achieves superior video generation quality. We provide a comprehensive review of the data curation lifecycle - including collection, processing, filtering and clustering - for the multi-stage training pipeline that involves extensive pre-training and incorporates quality-enhancement techniques such as self-supervised fine-tuning (SFT) and reinforcement learning (RL)-based post-training. We also present novel architectural, training, and inference optimizations that enable Kandinsky 5.0 to achieve high generation speeds and state-of-the-art performance across various tasks, as demonstrated by human evaluation. As a large-scale, publicly available generative framework, Kandinsky 5.0 leverages the full potential of its pre-training and subsequent stages to be adapted for a wide range of generative applications. We hope that this report, together with the release of our open-source code and training checkpoints, will substantially advance the development and accessibility of high-quality generative models for the research community.
A Quantitative Framework for Assessing Sleep Quality from EEG Time Series in Complex Dynamic Systems
Venue: arXiv cs.HC 2025
Year: 2025

Modern lifestyles contribute to insufficient sleep, impairing cognitive function and weakening the immune system. Sleep quality (SQ) is vital for physiological and mental health, making its understanding and accurate assessment critical. However, its multifaceted nature, shaped by neurological and environmental factors, makes precise quantification challenging. Here, we address this challenge by utilizing electroencephalography (EEG) for phase-amplitude coupling (PAC) analysis to elucidate the neurological basis of SQ, examining both states of sleep and wakefulness, including resting state (RS) and working memory. Our results revealed distinct patterns in beta power and delta connectivity in sleep and RS, together with the reaction time of working memory. A notable finding was the pronounced delta-beta PAC, a feature markedly stronger in individuals with good SQ. We further observed that SQ was positively correlated with increased delta-beta PAC. Leveraging these insights, we applied machine learning models to classify SQ at an individual level, demonstrating that the delta-beta PAC outperformed other EEG characteristics. These findings establish delta-beta PAC as a robust electrophysiological marker to quantify SQ and elucidate its neurological determinants.