OpenRaiser/Intern-Atlas huggingface dataset:
MERGE: Multi-faceted Hierarchical Graph-based GNN for Gene Expression Prediction from Whole Slide Histopathology Images
Venue: Conference CVPR 2025
Year: 2025

Recent advances in Spatial Transcriptomics (ST) pair histology images with spatially resolved gene expression profiles, enabling predictions of gene expression across different tissue locations based on image patches. This opens up new possibilities for enhancing whole slide image (WSI) prediction tasks with localized gene expression. However, existing methods fail to fully leverage the interactions between different tissue locations, which are crucial for accurate joint prediction. To address this, we introduce MERGE (Multi-faceted hiErarchical gRaph for Gene Expressions), which combines a multi-faceted hierarchical graph construction strategy with graph neural networks (GNN) to improve gene expression predictions from WSIs. By clustering tissue image patches based on both spatial and morphological features, and incorporating intra- and inter-cluster edges, our approach fosters interactions between distant tissue locations during GNN learning. As an additional contribution, we evaluate different data smoothing techniques that are necessary to mitigate artifacts in ST data, often caused by technical imperfections. We advocate for adopting gene-aware smoothing methods that are more biologically justified. Experimental results on gene expression prediction show that our GNN method outperforms state-of-the-art techniques across multiple metrics.
PTDiffusion: Free Lunch for Generating Optical Illusion Hidden Pictures with Phase-Transferred Diffusion Model
Venue: Conference CVPR 2025
Year: 2025

Optical illusion hidden picture is an interesting visual perceptual phenomenon where an image is cleverly integrated into another picture in a way that is not immediately obvious to the viewer. Established on the off-the-shelf text-to-image (T2I) diffusion model, we propose a novel training-free text-guided image-to-image (I2I) translation framework dubbed as \textbf{P}hase-\textbf{T}ransferred \textbf{Diffusion} Model (PTDiffusion) for hidden art syntheses. PTDiffusion harmoniously embeds an input reference image into arbitrary scenes described by the text prompts, producing illusion images exhibiting hidden visual cues of the reference image. At the heart of our method is a plug-and-play phase transfer mechanism that dynamically and progressively transplants diffusion features' phase spectrum from the denoising process to reconstruct the reference image into the one to sample the generated illusion image, realizing deep fusion of the reference structural information and the textual semantic information in the diffusion model latent space. Furthermore, we propose asynchronous phase transfer to enable flexible control to the degree of hidden content discernability. Our method bypasses any model training and fine-tuning process, all while substantially outperforming related text-guided I2I methods in image generation quality, text fidelity, visual discernibility, and contextual naturalness for illusion picture synthesis, as demonstrated by extensive qualitative and quantitative experiments. Our project is publically available at \href{https://xianggao1102.github.io/PTDiffusion_webpage/}{this web page}.
Preserving Clusters in Prompt Learning for Unsupervised Domain Adaptation
Venue: Conference CVPR 2025
Year: 2025

Recent approaches leveraging multi-modal pre-trained models like CLIP for Unsupervised Domain Adaptation (UDA) have shown significant promise in bridging domain gaps and improving generalization by utilizing rich semantic knowledge and robust visual representations learned through extensive pre-training on diverse image-text datasets. While these methods achieve state-of-the-art performance across benchmarks, much of the improvement stems from base pseudo-labels (CLIP zero-shot predictions) and self-training mechanisms. Thus, the training mechanism exhibits a key limitation wherein the visual embedding distribution in target domains can deviate from the visual embedding distribution in the pre-trained model, leading to misguided signals from class descriptions. This work introduces a fresh solution to reinforce these pseudo-labels and facilitate target-prompt learning, by exploiting the geometry of visual and text embeddings - an aspect that is overlooked by existing methods. We first propose to directly leverage the reference predictions (from source prompts) based on the relationship between source and target visual embeddings. We later show that there is a strong clustering behavior observed between visual and text embeddings in pre-trained multi-modal models. Building on optimal transport theory, we transform this insight into a novel strategy to enforce the clustering property in text embeddings, further enhancing the alignment in the target domain. Our experiments and ablation studies validate the effectiveness of the proposed approach, demonstrating superior performance and improved quality of target prompts in terms of representation.
DELT: A Simple Diversity-driven EarlyLate Training for Dataset Distillation
Venue: Conference CVPR 2025
Year: 2025

Recent advances in dataset distillation have led to solutions in two main directions. The conventional batch-to-batch matching mechanism is ideal for small-scale datasets and includes bi-level optimization methods on models and syntheses, such as FRePo, RCIG, and RaT-BPTT, as well as other methods like distribution matching, gradient matching, and weight trajectory matching. Conversely, batch-to-global matching typifies decoupled methods, which are particularly advantageous for large-scale datasets. This approach has garnered substantial interest within the community, as seen in SRe$^2$L, G-VBSM, WMDD, and CDA. A primary challenge with the second approach is the lack of diversity among syntheses within each class since samples are optimized independently and the same global supervision signals are reused across different synthetic images. In this study, we propose a new Diversity-driven EarlyLate Training (DELT) scheme to enhance the diversity of images in batch-to-global matching with less computation. Our approach is conceptually simple yet effective, it partitions predefined IPC samples into smaller subtasks and employs local optimizations to distill each subset into distributions from distinct phases, reducing the uniformity induced by the unified optimization process. These distilled images from the subtasks demonstrate effective generalization when applied to the entire task. We conduct extensive experiments on CIFAR, Tiny-ImageNet, ImageNet-1K, and its sub-datasets. Our approach outperforms the previous state-of-the-art by 2$\sim$5% on average across different datasets and IPCs (images per class), increasing diversity per class by more than 5% while reducing synthesis time by up to 39.3% for enhancing the training efficiency. Code is available at: https://github.com/VILA-Lab/DELT.
Attend to Not Attended: Structure-then-Detail Token Merging for Post-training DiT Acceleration
Venue: Conference CVPR 2025
Year: 2025

Diffusion transformers have shown exceptional performance in visual generation but incur high computational costs. Token reduction techniques that compress models by sharing the denoising process among similar tokens have been introduced. However, existing approaches neglect the denoising priors of the diffusion models, leading to suboptimal acceleration and diminished image quality. This study proposes a novel concept: attend to prune feature redundancies in areas not attended by the diffusion process. We analyze the location and degree of feature redundancies based on the structure-then-detail denoising priors. Subsequently, we introduce SDTM, a structure-then-detail token merging approach that dynamically compresses feature redundancies. Specifically, we design dynamic visual token merging, compression ratio adjusting, and prompt reweighting for different stages. Served in a post-training way, the proposed method can be integrated seamlessly into any DiT architecture. Extensive experiments across various backbones, schedulers, and datasets showcase the superiority of our method, for example, it achieves 1.55 times acceleration with negligible impact on image quality. Project page: https://github.com/ICTMCG/SDTM.
FlowRAM: Grounding Flow Matching Policy with Region-Aware Mamba Framework for Robotic Manipulation
Venue: Conference CVPR 2025
Year: 2025

Robotic manipulation in high-precision tasks is essential for numerous industrial and real-world applications where accuracy and speed are required. Yet current diffusion-based policy learning methods generally suffer from low computational efficiency due to the iterative denoising process during inference. Moreover, these methods do not fully explore the potential of generative models for enhancing information exploration in 3D environments. In response, we propose FlowRAM, a novel framework that leverages generative models to achieve region-aware perception, enabling efficient multimodal information processing. Specifically, we devise a Dynamic Radius Schedule, which allows adaptive perception, facilitating transitions from global scene comprehension to fine-grained geometric details. Furthermore, we integrate state space models to integrate multimodal information, while preserving linear computational complexity. In addition, we employ conditional flow matching to learn action poses by regressing deterministic vector fields, simplifying the learning process while maintaining performance. We verify the effectiveness of the FlowRAM in the RLBench, an established manipulation benchmark, and achieve state-of-the-art performance. The results demonstrate that FlowRAM achieves a remarkable improvement, particularly in high-precision tasks, where it outperforms previous methods by 12.0% in average success rate. Additionally, FlowRAM is able to generate physically plausible actions for a variety of real-world tasks in less than 4 time steps, significantly increasing inference speed.
Test-Time Visual In-Context Tuning
Venue: Conference CVPR 2025
Year: 2025

Visual in-context learning (VICL), as a new paradigm in computer vision, allows the model to rapidly adapt to various tasks with only a handful of prompts and examples. While effective, the existing VICL paradigm exhibits poor generalizability under distribution shifts. In this work, we propose test-time Visual In-Context Tuning (VICT), a method that can adapt VICL models on the fly with a single test sample. Specifically, we flip the role between the task prompts and the test sample and use a cycle consistency loss to reconstruct the original task prompt output. Our key insight is that a model should be aware of a new test distribution if it can successfully recover the original task prompts. Extensive experiments on six representative vision tasks ranging from high-level visual understanding to low-level image processing, with 15 common corruptions, demonstrate that our VICT can improve the generalizability of VICL to unseen new domains. In addition, we show the potential of applying VICT for unseen tasks at test time. Code: https://github.com/Jiahao000/VICT.
Prior Does Matter: Visual Navigation via Denoising Diffusion Bridge Models
Venue: Conference CVPR 2025
Year: 2025

Recent advancements in diffusion-based imitation learning, which show impressive performance in modeling multimodal distributions and training stability, have led to substantial progress in various robot learning tasks. In visual navigation, previous diffusion-based policies typically generate action sequences by initiating from denoising Gaussian noise. However, the target action distribution often diverges significantly from Gaussian noise, leading to redundant denoising steps and increased learning complexity. Additionally, the sparsity of effective action distributions makes it challenging for the policy to generate accurate actions without guidance. To address these issues, we propose a novel, unified visual navigation framework leveraging the denoising diffusion bridge models named NaviBridger. This approach enables action generation by initiating from any informative prior actions, enhancing guidance and efficiency in the denoising process. We explore how diffusion bridges can enhance imitation learning in visual navigation tasks and further examine three source policies for generating prior actions. Extensive experiments in both simulated and real-world indoor and outdoor scenarios demonstrate that NaviBridger accelerates policy inference and outperforms the baselines in generating target action sequences. Code is available at https://github.com/hren20/NaiviBridger.
Do We Really Need Curated Malicious Data for Safety Alignment in Multi-modal Large Language Models?
Venue: Conference CVPR 2025
Year: 2025

Multi-modal large language models (MLLMs) have made significant progress, yet their safety alignment remains limited. Typically, current open-source MLLMs rely on the alignment inherited from their language module to avoid harmful generations. However, the lack of safety measures specifically designed for multi-modal inputs creates an alignment gap, leaving MLLMs vulnerable to vision-domain attacks such as typographic manipulation. Current methods utilize a carefully designed safety dataset to enhance model defense capability, while the specific knowledge or patterns acquired from the high-quality dataset remain unclear. Through comparison experiments, we find that the alignment gap primarily arises from data distribution biases, while image content, response quality, or the contrastive behavior of the dataset makes little contribution to boosting multi-modal safety. To further investigate this and identify the key factors in improving MLLM safety, we propose finetuning MLLMs on a small set of benign instruct-following data with responses replaced by simple, clear rejection sentences. Experiments show that, without the need for labor-intensive collection of high-quality malicious data, model safety can still be significantly improved, as long as a specific fraction of rejection data exists in the finetuning set, indicating the security alignment is not lost but rather obscured during multi-modal pretraining or instruction finetuning. Simply correcting the underlying data bias could narrow the safety gap in the vision domain.
Acc3D: Accelerating Single Image to 3D Diffusion Models via Edge Consistency Guided Score Distillation
Venue: Conference CVPR 2025
Year: 2025

We present Acc3D to tackle the challenge of accelerating the diffusion process to generate 3D models from single images. To derive high-quality reconstructions through few-step inferences, we emphasize the critical issue of regularizing the learning of score function in states of random noise. To this end, we propose edge consistency, i.e., consistent predictions across the high signal-to-noise ratio region, to enhance a pre-trained diffusion model, enabling a distillation-based refinement of the endpoint score function. Building on those distilled diffusion models, we propose an adversarial augmentation strategy to further enrich the generation detail and boost overall generation quality. The two modules complement each other, mutually reinforcing to elevate generative performance. Extensive experiments demonstrate that our Acc3D not only achieves over a $20\times$ increase in computational efficiency but also yields notable quality improvements, compared to the state-of-the-arts.
Soft Self-labeling and Potts Relaxations for Weakly-supervised Segmentation
Venue: Conference CVPR 2025
Year: 2025

We consider weakly supervised segmentation where only a fraction of pixels have ground truth labels (scribbles) and focus on a self-labeling approach optimizing relaxations of the standard unsupervised CRF/Potts loss on unlabeled pixels. While WSSS methods can directly optimize such losses via gradient descent, prior work suggests that higher-order optimization can improve network training by introducing hidden pseudo-labels and powerful CRF sub-problem solvers, e.g. graph cut. However, previously used hard pseudo-labels can not represent class uncertainty or errors, which motivates soft self-labeling. We derive a principled auxiliary loss and systematically evaluate standard and new CRF relaxations (convex and non-convex), neighborhood systems, and terms connecting network predictions with soft pseudo-labels. We also propose a general continuous sub-problem solver. Using only standard architectures, soft self-labeling consistently improves scribble-based training and outperforms significantly more complex specialized WSSS systems. It can outperform full pixel-precise supervision. Our general ideas apply to other weakly-supervised problems/systems.
RoboBrain: A Unified Brain Model for Robotic Manipulation from Abstract to Concrete
Venue: Conference CVPR 2025
Year: 2025

Recent advancements in Multimodal Large Language Models (MLLMs) have shown remarkable capabilities across various multimodal contexts. However, their application in robotic scenarios, particularly for long-horizon manipulation tasks, reveals significant limitations. These limitations arise from the current MLLMs lacking three essential robotic brain capabilities: Planning Capability, which involves decomposing complex manipulation instructions into manageable sub-tasks; Affordance Perception, the ability to recognize and interpret the affordances of interactive objects; and Trajectory Prediction, the foresight to anticipate the complete manipulation trajectory necessary for successful execution. To enhance the robotic brain's core capabilities from abstract to concrete, we introduce ShareRobot, a high-quality heterogeneous dataset that labels multi-dimensional information such as task planning, object affordance, and end-effector trajectory. ShareRobot's diversity and accuracy have been meticulously refined by three human annotators. Building on this dataset, we developed RoboBrain, an MLLM-based model that combines robotic and general multi-modal data, utilizes a multi-stage training strategy, and incorporates long videos and high-resolution images to improve its robotic manipulation capabilities. Extensive experiments demonstrate that RoboBrain achieves state-of-the-art performance across various robotic tasks, highlighting its potential to advance robotic brain capabilities.
MVSAnywhere: Zero-Shot Multi-View Stereo
Venue: Conference CVPR 2025
Year: 2025

Computing accurate depth from multiple views is a fundamental and longstanding challenge in computer vision. However, most existing approaches do not generalize well across different domains and scene types (e.g. indoor vs. outdoor). Training a general-purpose multi-view stereo model is challenging and raises several questions, e.g. how to best make use of transformer-based architectures, how to incorporate additional metadata when there is a variable number of input views, and how to estimate the range of valid depths which can vary considerably across different scenes and is typically not known a priori? To address these issues, we introduce MVSA, a novel and versatile Multi-View Stereo architecture that aims to work Anywhere by generalizing across diverse domains and depth ranges. MVSA combines monocular and multi-view cues with an adaptive cost volume to deal with scale-related issues. We demonstrate state-of-the-art zero-shot depth estimation on the Robust Multi-View Depth Benchmark, surpassing existing multi-view stereo and monocular baselines.
Generating 6DoF Object Manipulation Trajectories from Action Description in Egocentric Vision
Venue: Conference CVPR 2025
Year: 2025

Learning to use tools or objects in common scenes, particularly handling them in various ways as instructed, is a key challenge for developing interactive robots. Training models to generate such manipulation trajectories requires a large and diverse collection of detailed manipulation demonstrations for various objects, which is nearly unfeasible to gather at scale. In this paper, we propose a framework that leverages large-scale ego- and exo-centric video datasets -- constructed globally with substantial effort -- of Exo-Ego4D to extract diverse manipulation trajectories at scale. From these extracted trajectories with the associated textual action description, we develop trajectory generation models based on visual and point cloud-based language models. In the recently proposed egocentric vision-based in-a-quality trajectory dataset of HOT3D, we confirmed that our models successfully generate valid object trajectories, establishing a training dataset and baseline models for the novel task of generating 6DoF manipulation trajectories from action descriptions in egocentric vision.
BIOMEDICA: An Open Biomedical Image-Caption Archive, Dataset, and Vision-Language Models Derived from Scientific Literature
Venue: Conference CVPR 2025
Year: 2025

The development of vision-language models (VLMs) is driven by large-scale and diverse multimodal datasets. However, progress toward generalist biomedical VLMs is limited by the lack of annotated, publicly accessible datasets across biology and medicine. Existing efforts are restricted to narrow domains, missing the full diversity of biomedical knowledge encoded in scientific literature. To address this gap, we introduce BIOMEDICA, a scalable, open-source framework to extract, annotate, and serialize the entirety of the PubMed Central Open Access subset into an easy-to-use, publicly accessible dataset. Our framework produces a comprehensive archive with over 24 million unique image-text pairs from over 6 million articles. Metadata and expert-guided annotations are also provided. We demonstrate the utility and accessibility of our resource by releasing BMCA-CLIP, a suite of CLIP-style models continuously pre-trained on the BIOMEDICA dataset via streaming, eliminating the need to download 27 TB of data locally. On average, our models achieve state-of-the-art performance across 40 tasks - spanning pathology, radiology, ophthalmology, dermatology, surgery, molecular biology, parasitology, and cell biology - excelling in zero-shot classification with a 6.56% average improvement (as high as 29.8% and 17.5% in dermatology and ophthalmology, respectively), and stronger image-text retrieval, all while using 10x less compute. To foster reproducibility and collaboration, we release our codebase and dataset for the broader research community.
Structure-Aware Correspondence Learning for Relative Pose Estimation
Venue: Conference CVPR 2025
Year: 2025

Relative pose estimation provides a promising way for achieving object-agnostic pose estimation. Despite the success of existing 3D correspondence-based methods, the reliance on explicit feature matching suffers from small overlaps in visible regions and unreliable feature estimation for invisible regions. Inspired by humans' ability to assemble two object parts that have small or no overlapping regions by considering object structure, we propose a novel Structure-Aware Correspondence Learning method for Relative Pose Estimation, which consists of two key modules. First, a structure-aware keypoint extraction module is designed to locate a set of kepoints that can represent the structure of objects with different shapes and appearance, under the guidance of a keypoint based image reconstruction loss. Second, a structure-aware correspondence estimation module is designed to model the intra-image and inter-image relationships between keypoints to extract structure-aware features for correspondence estimation. By jointly leveraging these two modules, the proposed method can naturally estimate 3D-3D correspondences for unseen objects without explicit feature matching for precise relative pose estimation. Experimental results on the CO3D, Objaverse and LineMOD datasets demonstrate that the proposed method significantly outperforms prior methods, i.e., with 5.7°reduction in mean angular error on the CO3D dataset.