OpenMed/multicare-articles huggingface dataset:
A Case of Malignant Melanoma Arising in Mediastinal Malignant Teratoma
Authors: Ikuma Nozaki, Yumi Tone, Junko Yamanaka, Hideko Uryu, Yuko Shimizu-Motohashi, Noriko Sato, Takeji Matsushita
Journal: Case Rep Pediatr (2018)
MeSH terms: Case Reports

We report about a 14-year-old boy who presented with an anterior mediastinal mass that was diagnosed as malignant teratoma. Surgical resection was performed along with pre- and postoperative chemotherapy. Although elevated alpha-fetoprotein became negative, he experienced pain in his right hip joint 3 months after resection. Systematic evaluation revealed multiple locations of metastasis, and the pathological diagnosis based on bone biopsy was malignant melanoma originating from malignant teratoma, which rapidly progressed. He died 15 months after diagnosis of the original malignant teratoma. Diagnosing and treating malignant transformation of teratoma, including malignant melanoma, is difficult because it is very rare. To our knowledge, this is the second reported case of malignant melanoma arising from a mediastinum malignant teratoma, with both cases having a poor prognosis. In addition to the follow-up of tumor markers, systematic evaluation, including imaging, should be considered even after remission to monitor malignant transformation of teratoma. We expect to establish a successful therapy and improve mortality rate after more such cases are accumulated.
Multiple myeloma: imaging evaluation of skeletal disease
Authors: Carlton Sexton, Candice Crichlow
Journal: J Community Hosp Intern Med Perspect (2013)
Keywords: imaging, multiple myeloma, pathological fracture, skeletal
MeSH terms: Case Reports

This patient is a 56-year-old woman with a history of IGG κ multiple myeloma diagnosed 15 years prior to admission. She had widespread lytic bone lesions and pathological fractures, which remarkably had not been accompanied by significant pain, but were mostly refactory to chemotherapy.
Malignant Mesothelioma of the Tunica Vaginalis Testis-A Malignancy Associated With Asbestos Exposure and Trauma: A Case Report and Literature Review
Authors: Aam A Baqui, Nicholas A Boire, Tajruba T Baqui, Dhanan J Etwaru
Journal: J Investig Med High Impact Case Rep (2019)
Keywords: asbestos, mesothelioma, testicular
MeSH terms: Asbestos / adverse effects, Lung Neoplasms / pathology, Mesothelioma / pathology, Testicular Hydrocele / pathology, Testicular Neoplasms / pathology, Testis / injuries, Testis / pathology, Case Reports, Review, Humans, Immunohistochemistry, Lung Neoplasms / etiology, Male, Mesothelioma / etiology, Mesothelioma, Malignant, Middle Aged, Occupational Exposure / adverse effects, Orchiectomy, Testicular Hydrocele / etiology, Testicular Neoplasms / etiology, Asbestos

In this article, we report an unusual case of a malignant mesothelioma of the testis, presenting as hydrocele. The patient has a known medical history of trauma and occupational exposure to asbestos. The clinical features of this injury are discussed together with its immunohistochemistry. Surgical intervention is discussed due to the nature of this pathology.
Beware of covert enemies: Candida orthopsilosis malignant otitis externa with base of the skull osteomyelitis, a case report and review of literature
Authors: Junais Koleri, Ahmad Al Bishawi, Israa' Al-Sheikh, Salman Qureshi, Muna AlMaslamani, Hamad Abdelhadi
Journal: IDCases (2021)
Keywords: candida orthopsilosis, moe, malignant otitis externa, osteomyelitis
MeSH terms: Case Reports

Background:
Malignant otitis externa (MOE) is a serious infection of the external auditory canal that is frequently associated with skull base osteomyelitis (SBO) as well as secondary neurological sequelae. Patients with poorly controlled diabetes mellitus or immunosuppression are at increased risk of developing such critical infection for multiple local and systemic factors. While most cases are secondary to bacterial infections particularlyPseudomonas aeruginosa, fungal infections are also occasionally encountered, often associated with delayed diagnosis and high morbidity and mortality.
Case report:
We report a case of a 63 years old man with uncontrolled diabetes mellitus who presented with symptoms and signs of MOE, supported by radiological assessments. The patient was treated presumptively with a prolonged course of antibiotics without clinical improvement, coupled with progression of radiological findings and significant disease extension. Reassessment with biopsies and tissue cultures from external auditory meatus, tempo-mandibular bone, as well as base of the skull grew Candida orthopsilosis. The patient received induction treatment with high dose liposomal amphotericin followed by fluconazole to control disease progression and complications.
Conclusion:

Candida MOE with secondary skull base osteomyelitis is rare and difficult to diagnose with no clear guidance on assessment and management. Clinicians should be aware of the unusual presentations where microbiological and histopathological evaluations are essential for proper management.
Dunbar syndrome - case report
Authors: Sarah Maria Lemos de Campos, Rafael Prado Pessoa, João Paulo de Araújo Pelegrini, Henrique Fernandes Silveira, Maria Fernanda Lopes Diniz, Maria Passos Bianchini, Leonardo Soares Lopes, Marcus Eduardo Valadares Meireles Martins da Costa
Journal: J Vasc Bras (2023)
Keywords: dunbar, celiac trunk, ligament
MeSH terms: Case Reports

Dunbar syndrome is diagnosed by excluding other possible causes of abdominal pains. Surgical treatment comprises complete dissection of the ligament and the surrounding nerve ganglion. This report describes the case of a previously healthy 45-year-old male patient who presented with epigastric abdominal pain irradiating to the back and weakness. Initially, abdominal computed tomography was ordered, showing arteriopathy of the celiac trunk and mesenteric artery with stenosis. The patient underwent surgical treatment because of the refractory pain, but findings were nonspecific. It was necessary to continue workup with serial angiotomography to follow the case. After around 6 months, thickening of the arcuate ligament was found, with compression of the proximal third of the celiac trunk and 80% stenosis. The patient therefore underwent laparoscopy to relieve celiac trunk compression, with satisfactory postoperative recovery.
Enterovesical fistula: a rare complication of urethral catheterization
Authors: Amr Hawary, Laurence Clarke, Alasdair Taylor, Peter Duffy
Journal: Adv Urol (2009)
MeSH terms: Case Reports

This report describes the case of an eighty-two-year old lady with an indwelling urethral catheter inserted eight years prior to her presentation to manage her urinary incontinence. She underwent radiotherapy for muscle-invasive bladder cancer (stage T2b) in 1991 and had a laparotomy and drainage of an appendicular abscess in her early twenties. She presented with a short history of fecaluria, pneumaturia, and passage of urine per rectum. On laparotomy she was found to have an inflated catheter balloon that has eroded through the bladder wall into the lumen of a terminal ileal segment. To our knowledge this is the first reported case in literature of a patient developing an enterovesical fistula as a result of a urethral catheter eroding through the bladder wall into the bowel lumen. There are numerous known complications of long-term urethral catheterization. They include recurrent urinary tract infections, recurrent pyelonephritis, sepsis, urethral stricture, blocked and retained catheters, among many other reported complications. This case describes an unusual presentation secondary to an even more unusual complication. This should be considered when handling patients with indwelling urethral catheters inserted in unhealthy bladders.
Autoimmune thyroiditis presenting as palmoplantar keratoderma
Authors: Sara Lestre, Eva Lozano, Cláudia Meireles, Ana Barata Feio
Journal: Case Rep Med (2010)
MeSH terms: Case Reports

Palmoplantar keratoderma is a heterogeneous group of hereditary and acquired disorders characterized by abnormal thickening of palms and soles. Hypothyroidism is an unusual cause of palmoplantar keratoderma, rarely reported in the literature. We report a case of a 43-year-old woman presented with a 3-month history of a diffuse palmoplantar hyperkeratosis unresponsive to topical keratolytics and corticosteroids. Her past medical and family histories were unremarkable. She complained of recent asthenia, mood changes and constipation. Laboratory evaluation revealed an autoimmune thyroiditis with hypothyroidism. Other causes of acquired palmoplantar keratoderma were excluded. After hormonal replacement therapy institution, a gradual improvement of skin condition was observed. The diagnosis of underlying causes for acquired palmoplantar keratoderma can be a difficult task; however its recognition is essential for successful treatment results. Although a very rare association, hypothyroidism must be suspected in patients with acquired palmoplantar keratoderma, particularly when it occurs in association with systemic symptoms.
Case Report: Compound Heterozygous Variants of SLC13A3 Identified in a Chinese Patient With Acute Reversible Leukoencephalopathy and α-Ketoglutarate Accumulation
Authors: Qingyun Kang, Liming Yang, Hongmei Liao, Sai Yang, Haiyang Yang, Zeshu Ning, Caishi Liao, Liwen Wu
Journal: Front Pediatr (2021)
Keywords: nadc3, slc13a3, case report, leukoencephalopathy, α-ketoglutarate
MeSH terms: Case Reports

Background: SLC13A3 gene encodes the Na+/dicarboxylate cotransporter 3 (NaDC3), which locates on the plasma membrane and is mainly expressed in kidney, astrocytes and the choroid plexus. It imports four to six carbon dicarboxylates together with three Na+ ions into the cytosol. Nowadays, pathogenic variants of SLC13A3 gene were found to cause acute reversible leukoencephalopathy and α-ketoglutarate accumulation (ARLIAK) in patients. Here, we report two novel SLC13A3 variants c.185C>T (p.T62M) and c.331C>T (p.R111*) identified in a Chinese patient with ARLIAK. Case Presentation: The patient was a Chinese girl aged 13 years and 7 months old, who had acute, recurrent neurological deterioration during two febrile episodes. She presented with reversible leukoencephalopathy and increased urinary excretion of α-ketoglutarate. Genetic studies revealed compound heterozygous variants (c.185C>T, p.T62M, and c.331C>T, p.R111*) in SLC13A3, which had not been reported previously. Conclusions: These findings expand the variant spectrum of SLC13A3, providing the basis for the further study of this rare disease.
Union of Brodsky type 1/Eichenholtz stage III Charcot neuroarthropathy after forefoot arthrodesis
Authors: Ananto Satya Pradana, Krisna Yuarno Phatama, Adhi Satrio Utomo, Muhammad Hilman Bimadi, Marvin Anthony Putera, William Putera Sukmajaya, Edi Mustamsir, Mohamad Hidayat
Journal: Int J Surg Case Rep (2020)
Keywords: case report, charcot neuroarthropathy, diabetes mellitus, forefoot arthrodesis, surgical intervention
MeSH terms: Case Reports

Introduction:
One of the surgical intervention options for Charcot neuroarthropathy (CN) is arthrodesis. The arthrodesis procedure for the foot and ankle joint have been widely used in previous studies. This study aimed to evaluate the functional and radiological outcomes after arthrodesis procedure for the CN patient with Brodsky type 1/Eichenholtz stage III.
Presentation of case:
A 49-years-old diabetic woman presented with alteration of her right foot's shape and a cracking sensation while walking in the last six months. Rocker-bottom deformity and a decreased sensation on the right foot were found, and the initial American Orthopaedic Foot & Ankle Society (AOFAS) score was 45. Subsequently, forefoot arthrodesis of the right foot was performed.
Discussion:
Several studies state that arthrodesis procedure is often used for CN management in order to achieve a plantigrade and stable foot. This study presents an improvement of the foot arch, AOFAS score, and union of the talus six months after surgery.
Conclusion:
The arthrodesis procedure by using screws and Kirschner wire (K-wire) fixation is an effective method in CN management if the patient is compliant. This study showed a good result, anatomically restored the foot arch, and excellent radiological union, but different tools to analyze foot functional status and longer follow up period are needed for a better analysis.
Systemic adverse events after screening of retinopathy of prematurity with mydriatic
Authors: Shumpei Obata, Taku Imamura, Masashi Kakinoki, Takahide Yanagi, Yoshihiro Maruo, Masahito Ohji
Journal: PLoS One (2021)
MeSH terms: Drug-Related Side Effects and Adverse Reactions / diagnosis, Mass Screening, Mydriatics / adverse effects, Retinopathy of Prematurity / diagnosis, Research Support, Non-U.S. Gov't, Body Weight, Drug-Related Side Effects and Adverse Reactions / epidemiology, Drug-Related Side Effects and Adverse Reactions / pathology, Female, Gestational Age, Humans, Infant, Infant, Newborn, Infant, Premature, Male, Medical Records, Mydriatics / administration & dosage, Ophthalmic Solutions / administration & dosage, Ophthalmic Solutions / adverse effects, Phenylephrine / administration & dosage, Phenylephrine / adverse effects, Retinopathy of Prematurity / complications, Retinopathy of Prematurity / epidemiology, Retinopathy of Prematurity / pathology, Tropicamide / administration & dosage, Tropicamide / adverse effects, Mydriatics, Ophthalmic Solutions, Phenylephrine, Tropicamide

Purpose:
To evaluate systemic adverse events after screening for retinopathy of prematurity (ROP) performed with mydriatic.
Methods:
This was a retrospective case series study. Medical records of consecutive patients who underwent screening for ROP with 0.5% phenylephrine and 0.5% tropicamide eyedrops were retrospectively reviewed. The score of abdominal distention (0-5), volume of milk sucked and volume of stool, along with systemic details (pulse and respiration rates, blood pressure and number of periods of apnea) were collected at 1 week and 1 day before ROP examination, and at 1 day after examination. Results were compared between the days before and after examination. Correlation between body weight at the time of examination and the score of abdominal distention was examined. The numbers of infants with abdominal and/or systemic adverse events were compared between pre- and post-examination periods.
Results:
Eighty-six infants met the inclusion criteria. The score of abdominal distention increased from 2.0 at 1 day before examination to 2.3 at 1 day after examination (p = 0.005), and the number of infants who had worsened abdominal distension increased after examination (p = 0.01). Infants with lower body weight had a higher score of abdominal distention (p < 0.0001, r = -0.57). The number of infants with reduced milk consumption increased after examination (p = 0.0001), as did the number of infants with decreased pulse rate (p = 0.0008).
Conclusions:
Screening for ROP with mydriatic may have adverse effects on systemic conditions. Infants should be carefully monitored after ROP screening with mydriatic.
Transient, Recurrent Central Nervous System Clinical Manifestations of X-Linked Charcot-Marie-Tooth Disease Presenting with Very Long Latency Periods between Episodes: Is Prolonged Sun Exposure a Provoking Factor?
Authors: Andria Tziakouri, Konstantinos Natsiopoulos, Kleopas A Kleopa, Costas Michaelides
Journal: Case Rep Neurol Med (2020)
MeSH terms: Case Reports

Charcot-Marie-Tooth disease is one of the most common inherited neurological disorders affecting the peripheral nervous system. The common clinical manifestations of the disease are distal muscle weakness and atrophy, often associated with a characteristic steppage gait and foot deformities. Transient acute and recurrent or chronic central nervous system manifestations, predominantly, dysarthria, dysphagia, motor weakness, and ataxia, have been recognized as a feature of the X-linked type 1 of CMT (CMTX1). The CNS symptoms occur typically in young age and often precede the clinical manifestation of the polyneuropathy. Several predisposing factors such as exercise, fever, and returning from areas of high altitude have been described as triggers of the CNS symptoms; however, in many cases, a substantial cause remains undetermined. In this report, we describe a patient with three attacks of transient CNS deficits at the ages of 11, 21, and 38 years, respectively, which were also accompanied by transient white matter abnormalities on MRI. Two of the attacks occurred after prolonged exposure to sunlight. In our knowledge, this is the first documented case with such long latency periods between CNS attacks as well as the only report describing intense sun exposure as a possible provoking factor.
Fatal Hypogammaglobulinemia 3 Years after Rituximab in a Patient with Immune Thrombocytopenia: An Underlying Genetic Predisposition?
Authors: Jean-François Viallard, Marie Parrens, Frédéric Rieux-Laucat
Journal: Case Reports Immunol (2019)
MeSH terms: Case Reports

We report the case of a young woman who developed, 3 years after stopping Rituximab (RTX) prescribed for immune thrombocytopenia (ITP), a severe immunodeficiency leading to fatal pulmonary Epstein-Barr virus-positive diffuse large B-cell lymphoma. Genetic analysis led us to identify four missense mutations known to affect immune-deficiency-associated genes (FAS-ligand (FASL) gene (p.G167R); perforin-1 (PRF1 (p.R55C) gene; the Bloom syndrome RecQ-Like helicase (BLM) gene and the Moesin (MSN) (p.A122T) gene). The heterozygous mutation in the FASL gene, not present in the Genome Aggregation Database or ClinVar database, could suggest atypical Autoimmune LymphoProliferative Syndrome and its role in this patient's immunodepression is discussed. This observation strengthens the role of FASL gene mutation in severe clinical phenotypes of primary immune deficiency and raises new questions about the genetic background of ITP occurring in young people in a context of immunodeficiency.
Case Report: Adult Right-Sided Bochdalek Hernia Complicated by Intrathoracic Bowel Perforation
Authors: Jan Philipp Ramspott, Stephan Regenbogen, Tarkan Jäger, Michael Lechner, Franz Mayer, Ana Gabersek, Klaus Emmanuel, Philipp Schredl
Journal: Front Surg (2021)
Keywords: bochdalek hernia, hernia, mesh, repair, suture, thoracic complication
MeSH terms: Case Reports

Right-sided Bochdalek hernia is a mostly congenital condition of the diaphragm caused by a persistence of the pleuroperitoneal cavity and a rare disease in adults. As it often presents as an emergent situation, urgent diagnostics and surgical intervention are essential to reduce morbidity and mortality rates. Choosing the right surgical approach (abdominal, thoracic, or a combination of both) can be very challenging for clinicians. Here, we report a case of a 40-year-old woman, who presented with severe abdominal pain and tachypnoea. Imaging revealed a right-sided Bochdalek hernia. Emergency laparotomy was performed followed by reduction of hernia content, right-sided hemicolectomy, and side-to-side anastomosis from the ileum to the transverse colon due to intestinal ischemia and intrathoracic bowel perforation. The post-operative course was complicated by a pleural empyema. Therefore, the patient underwent thoracotomy. One year after surgical repair the patient had no recurrence. Here, we discuss feasible approaches for the surgical management of complicated Bochdalek hernias.
MACI "Sandwich" Technique for a Large Osteochondritis Dissecans Lesion: A Case Report
Authors: Bhumit Desai, Graylin Jacobs, Deryk Jones
Journal: Case Rep Orthop (2023)
MeSH terms: Case Reports

There is widespread use of matrix-induced autologous chondrocyte implantation. Initial use of autologous bone grafting in combination with the matrix-induced autologous chondrocyte implantation procedure has shown efficacy in small- to medium-sized osteochondral lesions. This case report demonstrates use of the "Sandwich" technique in a large, deep osteochondritis dissecans lesion of the medial femoral condyle. Technical considerations that are key to containment of the lesion and outcomes are reported.
Case report: acute myocardial infarction in the setting of acute transcatheter aortic valve thrombus
Authors: Elsa Hebbo, Alessandro El Khoury, Dounia Iskandarani, Fadi Sawaya
Journal: Front Cardiovasc Med (2023)
Keywords: acute coronary syndrome, anticoagulation, interventional cardiology acute myocardial infarction, thromboembolism, transcatheter aortic valve replacement, valve thrombus
MeSH terms: Case Reports

We describe a case of valve thrombosis and a subsequent thromboembolic event within only 10 days of transcatheter aortic valve implantation (TAVI). Postprocedural anticoagulants are not standard of care medications post-TAVI in patients without atrial fibrillation. Valve thrombosis is an indication to initiate anticoagulation to resolve and prevent further thrombus.
Atrioventricular Cross-Talk Leading to Ventricular Pacing Inhibition in a Dual-Chamber ICD
Authors: Luuk Debie, Bernard Broers, Jurren van Opstal, Berry M van Gelder
Journal: Case Rep Cardiol (2011)
MeSH terms: Case Reports

We report atrio-ventricular cross talk in a patient with a dual chamber ICD leading to ventricular pacing inhibition. This was observed in an ICD without the ventricular safety pace option, which normally is a sufficient protection against this phenomenon. Cross talk could be prevented effectively by reprogramming ventricular sensitivity to a less sensitive setting.
Case Report: Ultrasound-Guided Percutaneous Microwave Ablation of Focal Nodular Hyperplasia in a 9-Year-Old Girl
Authors: Zhiguang Yao, Qingjing Zeng, Xuan Yu, Shulian Lin, Shuanglan Jiang, Da Ma, Kai Li
Journal: Front Pediatr (2021)
Keywords: ablation, case report, focal nodular hyperplasia, pediatrics, ultrasonics
MeSH terms: Case Reports

Focal nodular hyperplasia (FNH) is a rare benign tumor-like space-occupying lesion of the liver that is especially rare in children. Since there have been no reports of malignant progression of this disease and these lesions remain unchanged for a long period of time or even disappear in some cases, it remains controversial whether clinical treatment is needed. However, if the diagnosis is unclear, the patient has symptoms or the lesion becomes enlarged during follow-up, clinical treatment should be considered. Here, we report the first case of FNH near the gallbladder treated by ultrasound-guided percutaneous microwave ablation (MWA) in a 9-year-old girl.
Primary Peritoneal Angiosarcoma Metastatic to Liver and Bone without History of Radiation Therapy
Authors: Way Chiang, Zofia Tynski
Journal: Case Rep Pathol (2018)
MeSH terms: Case Reports

Angiosarcoma is a rare vascular soft tissue tumor of endothelial origin most commonly seen in the elderly as a primary cutaneous head and neck malignancy. Furthermore, a peritoneal angiosarcoma is an exceedingly rare entity. This is the second case of primary peritoneal angiosarcoma reported in literature that is not associated with prior radiotherapy. Herein, we describe a case of primary peritoneal angiosarcoma metastatic to both the liver and bone in a male patient with metachronous renal cell carcinoma and parathyroid adenoma.