OpenMed/multicare-articles huggingface dataset:
Pulmonary Veno-Occlusive Disease: A Rare Cause of Pulmonary Hypertension
Authors: Said Hajouli, Muhamad Alhaj Moustafa, Jessica S Wang Memoli
Journal: J Investig Med High Impact Case Rep (2019)
Keywords: hypoxia, lung transplantation, pulmonary hypertension, pulmonary veno-occlusive disease, ventilation-perfusion lung scan
MeSH terms: Pulmonary Arterial Hypertension / etiology, Pulmonary Veno-Occlusive Disease / diagnosis, Case Reports, Adult, Female, Humans, Lung Transplantation, Pulmonary Veno-Occlusive Disease / complications, Tomography, X-Ray Computed

Pulmonary veno-occlusive disease (PVOD) is a rare entity that is usually mistaken with pulmonary arterial hypertension (PAH) but is considered class I' of PAH. It is important to subclassify PVOD and distinguish it from PAH as treatment with vasodilators in PVOD patients is controversial and may be fatal. In this article, we describe a case of PVOD and how we diagnosed it.
A family pedigree of malignancies associated with BRCA1 pathogenic variants: a reflection of the state of art in China
Authors: Wenhui Li, Lei Li, Ming Wu
Journal: Hered Cancer Clin Pract (2019)
Keywords: brca mutations, genetic counseling, ovarian cancer, risk-reducing salpingo-oophorectomy
MeSH terms: Case Reports

Background:
Little is known about the status of genetic counseling for ovarian cancer in China.
Case presentation:
We report a four-generation Chinese family with several types of cancer. The proband was a patient with high-grade serous ovarian cancer (HGSOC) who was found to harbor a pathogenic BRCA1 variant. Cosegregation analysis identified 7 of 9 relatives with the same deleterious variant. One month after the genetic test, one female carrier 54 years of age was diagnosed with stage IVB HGSOC, and another female 55 years of age accepted risk-reducing salpingo-oophorectomy, which revealed occult cancer of the fallopian tube (Stage IA).
Conclusions:
Genetic counseling and testing for ovarian cancer in China have fallen behind international trends. Innovative studies and practices are urgently needed to establish models for cancer screening, prevention and treatment.
Abdominal heterotopic pregnancy after in vitro fertilization and embryo transfer following bilateral salpingectomy: A case report and literature review
Authors: Yifeng Liu, Yu Li, Keting Li, Shuangdi Li
Journal: Front Reprod Health (2022)
Keywords: assisted reproductive technology, bilateral salpingectomy, heterotopic pregnancy, intraperitoneal hemorrhage, laparoscopy
MeSH terms: Case Reports

Background:
Risk of heterotopic pregnancy following bilateral salpingectomy has increased considerably due to the widespread use of assisted reproductive technology. Poor understanding of this condition often causes delayed or missed diagnosis.
Objective:
In this report, we describe the case of a 30-year-old pregnant woman with lower abdominal pain lasting for half a day and a history of bilateral salpingectomy. Two embryos had been transferred 21 days preceding her presentation.
Methods:
Case report.
Results:
Laparoscopic surgery revealed intraperitoneal hemorrhage and proper ovarian ligament pregnancy confirmed by histopathology. Viable intrauterine pregnancy was verified 3 days later by ultrasound examination.
Conclusion:
Heterotopic pregnancy is a serious condition that may be life-threatening. Clinicians should be aware of the potential for heterotopic pregnancy in patients receiving in vitro fertilization and embryo transfer after bilateral salpingectomy.
Synchronous malignant renal mass in patient with a Lung cancer: case report and literature review
Authors: Aicha Mazouz, Lamiae Amaadour, Ihsane souaf, Hinde El Fatemi, Afaf Amarti, Mohamed Ait Erraisse, Essaadia Oubelkacem, Touria Bouhafa, Yassir Tahiri, Mohammed Fadl Tazi, Soufiane Mellas, Samia Arifi, Nawfel Mellas
Journal: Pan Afr Med J (2015)
Keywords: synchronous malignant renal mass, differentiating features, non-small cell lung cancer, synchronous primary tumor
MeSH terms: Carcinoma, Renal Cell / pathology, Kidney Neoplasms / pathology, Lung Neoplasms / pathology, Neoplasms, Multiple Primary / pathology, Case Reports, Review, Carcinoma, Renal Cell / therapy, Chemoradiotherapy, Adjuvant, Combined Modality Therapy, Humans, Kidney Neoplasms / therapy, Lung Neoplasms / therapy, Male, Middle Aged, Neoplasms, Multiple Primary / therapy, Nephrectomy

The finding on imaging (computed tomography scan or magnetic resonance imaging) of synchronous malignant renal mass in patient with an active nonrenal malignancy without renal specific symptoms is not frequent and diagnostic evaluation can be challenging. We describe a 54-year-old Moroccan male former chronic smoker who presented to our hospital with dry cough and impairment of the performance status. The imaging found a tumor mass in the left upper lobe of the lung associated to mediastinal lymph node and a scanno-guided biopsy of this tumor showed a non small cell lung cancer. The radiological staging revealed a solitary renal mass in the right kidney. The patient received firstly two cycles of a lung cancer chemotherapy with a partial response in the lung and a stability of the renal mass. Consequently, he underwent a scanno-guided biopsy of this mass which confirmed a synchronous clear cell renal carcinoma. The patient got chemo radiotherapy for the lung cancer and then after that he got a partial nephrectomy. He is still under a good control with more than 2 years after the initial diagnosis.
A case report of metastatic mixed adeno-neuroendocrine carcinoma of the anus presenting as anal pain
Authors: Li Xian Lim, Marie Shella De Robles, Robert Duncan Winn, Kimberly Anne Hart
Journal: Int J Surg Case Rep (2020)
Keywords: adenocarcinoma, case report, mixed adeno-neuroendocrine carcinoma, mixed neuroendocrine non-neuroendocrine neoplasm, small cell carcinoma
MeSH terms: Case Reports

Introduction:
Mixed adeno-neuroendocrine carcinoma (MANEC) is a rare disease, and much of the available literature to date has consisted of case reports. A recent systematic review revealed heterogeneity in the data as not all reports documented treatment regimens and course of disease. The recent 2019 WHO update on neuroendocrine carcinoma nomenclature adds to the pre-existing classification system based on biologic activity, to better represent the spectrum of neuroendocrine non-neuroendocrine tumours (Frizziero et al., 2020).
Presentation of case:
We present a case of a patient who presented with anal pain, had a wide local excision which on histopathology revealed poorly differentiated MANEC. Despite adjuvant chemotherapy with cisplatin and etoposide as well as pelvic radiotherapy, the patient developed bi-lobar liver metastases within 9 months of initial presentation. The patient succumbed to colonic perforation 10 months after initial presentation.
Discussion:
Most patients present with advanced disease with site-specific symptoms, and despite treatment of localised disease, many recur with distant metastasis.
Conclusion:
Although rare, this disease is highly aggressive, thus it is hoped that more clinicians can be made aware about its various clinical manifestations and disease course.
Syringomyelia with Chiari I malformation presenting as hip charcot arthropathy: a case report and literature review
Authors: Roya Memarpour, Basheer Tashtoush, Lydia Issac, Fernando Gonzalez-Ibarra
Journal: Case Rep Neurol Med (2015)

Neuroarthropathy (neuropathic osteoarthropathy), also known as Charcot joint, is a condition characterized by a progressive articular surface destruction in the setting of impaired nociceptive and proprioceptive innervation of the involved joint. It is seen most commonly in the foot and ankle secondary to peripheral neuropathy associated with diabetes mellitus. Cases of hip (Charcot) neuroarthropathy are rare and almost exclusively reported in patients with neurosyphilis (tabes dorsalis). We report a case of a 36-year-old man who presented to the emergency department complaining of right hip pain. On physical examination, pain and thermal sensory deficits were noted in the upper torso with a cape-like distribution, as well as signs of an upper motor neuron lesion in the left upper and lower extremities. A magnetic resonance imaging study (MRI) of the right hip showed evidence of early articular surface destruction and periarticular edema consistent with hip Charcot arthropathy. An MRI of the spine revealed an Arnold-Chiari type I malformation with extensive syringohydromyelia of the cervical and thoracic spine.
Recurrent Episodes of Fluid Retention in a Patient with Heart Failure and Chronic Kidney Disease: The Additional Value of Implantable Monitoring Systems
Authors: Marc Vanderheyden, Sofie Verstreken, Richard Houben
Journal: Case Rep Cardiol (2021)
MeSH terms: Case Reports

The additional role of continuous monitoring of filling pressures and impedance in heart failure patients with chronic kidney disease remains undetermined. In this case report, the effects of diuretic therapy and renal replacement therapy by hemodialysis upon right ventricular filling pressures and impedance are described in a patient with end-stage heart failure and end-stage chronic kidney disease (grade 5). We demonstrated that unloading of the heart by hemodialysis partly restored the blunted Frank-Starling relationship.
Delayed Guillain-Barré Syndrome after Bariatric Surgery: A Report of Three Cases
Authors: Alana H Sunbol, Sarah Almaghrabi, Shahd J Al Aslany, Mashael M Aldairi, Sara A Makhdum, Nora Trabulsi, Mohammed A Almekhlafi, Mohammed Nassif
Journal: Case Rep Surg (2018)
MeSH terms: Case Reports

Surgeries carry a risk of complications. Polyneuropathies, including Guillain-Barré syndrome (GBS), are potential complications of bariatric surgery. The incidence of these conditions is expected to increase as these surgeries become increasingly popular. We present a case report of three patients who developed a polyneuropathy after bariatric surgery. GBS was diagnosed in each patient, with nutritional deficiencies being suspected as a contributing factor. All patients began a 5-day intravenous immunoglobulin course in addition to receiving rehabilitative support, multivitamins, intravenous thiamine, vitamin D (therapeutic dose), and selenium. The patients' symptoms improved but did not completely resolve. GBS can be a complication of bariatric surgery. Although a clear cause-effect relationship cannot be established for the present cases, the cumulative literature on the subject suggests that it is important to include it as a potential risk when counseling patients for such surgeries.
Increasing threat of brucellosis to low-risk persons in urban settings, China
Authors: Shouyi Chen, Hao Zhang, Xiaoning Liu, Wenjing Wang, Shuiping Hou, Tingting Li, Shuoxian Zhao, Zhicong Yang, Chengyao Li
Journal: Emerg Infect Dis (2014)
Keywords: china, bacteria, brucellosis, human infection, public health, risk, urban setting
MeSH terms: Brucella melitensis / classification, Brucellosis / diagnosis, Twins, Case Reports, Research Support, Non-U.S. Gov't, Adult, Brucella melitensis / genetics, Brucella melitensis / isolation & purification, Brucellosis / drug therapy, Brucellosis / transmission, China, DNA, Bacterial, Female, Humans, Infant, Male, Multilocus Sequence Typing, Phylogeny, DNA, Bacterial

Cases of brucellosis were diagnosed in 3-month-old twins and their mother. An epidemiologic survey suggested that raw sheep or goat meat might be the source of Brucella melitensis infection. This finding implies that the increasing threat of brucellosis might affect low-risk persons in urban settings in China.
Toxic Anterior Segment Syndrome following Phacoemulsification Secondary to Overdose of Intracameral Gentamicin
Authors: Yaran Koban, Selim Genc, Gorkem Bilgin, Halil Huseyin Cagatay, Metin Ekinci, Melin Gecer, Zeliha Yazar
Journal: Case Rep Med (2014)

Objective. To report a case of toxic anterior segment syndrome (TASS) that was caused by inadvertent anterior chamber and cornea stromal injection with high dose gentamicin following cataract surgery. Methods. Case report. Results. We report a 72-year-old female patient who developed TASS that was caused by high dose gentamicin (20 mg/0.5 mL), which was inadvertently used during the formation of the anterior chamber and hydration of the corneal incision. Unlike previous cases, hyphema and hemorrhagic fibrinous reaction were seen in the anterior chamber. Despite treatment, bullous keratopathy developed and penetrating keratoplasty was performed. The excised corneal button was sent for histopathological examination. Conclusions. Subconjunctival gentamicin is highly toxic to the corneal endothelium and anterior chamber structures. Including it on the surgical table carries a potentially serious risk for contamination of the anterior chamber.
A newly developed robot suit hybrid assistive limb facilitated walking rehabilitation after spinal surgery for thoracic ossification of the posterior longitudinal ligament: a case report
Authors: Harutoshi Sakakima, Kosei Ijiri, Fumiyo Matsuda, Hiroyuki Tominaga, Takanori Biwa, Kazunori Yone, Yoshiyuki Sankai
Journal: Case Rep Orthop (2013)

Most patients with thoracic ossification of the posterior longitudinal ligament (OPLL) exhibit delayed recovery of gait dysfunction after spinal injury. The hybrid assistive limb (HAL) is a new robot suit controlling knee and hip joint motion by detecting very weak bioelectric signals on the surface of the skin. This study is to report the feasibility and benefits of patient-assistive HAL walking rehabilitation for facilitating locomotor function after spinal surgery. The patient was a 60-year-old woman with thoracic OPLL, and her motor and sensory paralyses did not improve after spinal surgery, indicating severe impairment in the paretic legs. The subject underwent 6 HAL sessions per week for 8 weeks, consisting of a standing and sitting exercise and walking on the ground with HAL. Clinical outcomes were evaluated before and after HAL training and 1 year after surgery. The subject improved considerably as a result of HAL training. Subsequently, her walking ability recovered rapidly, and she was able to walk unaided six months after surgery. This case study suggests that HAL training is a feasible and effective option to facilitating locomotor function and the early HAL training with physiotherapy may enhance motor recovery of patients with residual paralysis after surgery.
The Rare Coincidence: Nonrecurrent Laryngeal Nerve Pointed by a Zuckerkandl's Tubercle
Authors: Emin Gurleyik, Sami Dogan, Omer Gunal, Mevlut Pehlivan
Journal: Case Rep Med (2012)
MeSH terms: Case Reports

The safety of thyroid operations mainly depends on complete anatomical knowledge. Anatomical and embryological variations of the inferior laryngeal nerve (ILN), of the thyroid gland itself and unusual relations between ILN and the gland threaten operation security are discussed. The patient with toxic multinodular goiter is treated with total thyroidectomy. During dissection of the right lobe, the right ILN which has nonrecurrent course arising directly from cervical vagus nerve is identified and fully isolated until its laryngeal entry. At the operation, we observe bilateral Zuckerkandl's tubercles (ZTs) as posterior extension of both lateral lobes. The left ILN has usual recurrent course in the trachea-esophageal groove. The right ZT is placed between upper and middle third of the lobe points the nonrecurrent ILN. The coincidence of non-recurrent ILN pointed by a ZT is rare anatomical and embryological feature of this case. Based on anatomical and embryological variations, we suggest identification and full exposure of ILN before attempting excision of adjacent structures, like the ZT which has surgical importance for completeness of thyroidectomy.
Intramedullary non-specific inflammatory lesion of thoracic spine: a case report
Authors: Alessandro Landi, Valerio Di Norcia, Demo Eugenio Dugoni, Roberto Tarantino, Martina Cappelletti, Manila Antonelli, Antonio Santoro, Roberto Delfini
Journal: World J Surg Oncol (2010)
MeSH terms: Inflammation / diagnosis, Spinal Cord Neoplasms / diagnosis, Thoracic Wall / pathology, Case Reports, Aged, Diagnosis, Differential, Female, Humans, Inflammation / therapy, Magnetic Resonance Imaging, Spinal Cord Neoplasms / therapy

Background:
There are several non-neoplastic lesions which mimick intramedullary spinal cord neoplasm in their radiographic and clinical presentation. These can be classified as either infectious (TB, fungal, bacterial, parasytic, syphilis, CMV, HSV) and non-infectious (sarcoid, MS, myelitis, ADEM, SLE) inflammatory lesions, idiopathic necrotizing myelopathy, unusual vascular lesions and radiation myelopathy. Although biopsy may be indicated in many cases, an erroneous diagnosis of intramedullary neoplasm can often be eliminated pre-operatively.
Case description:
the authors report a very rare case of intramedullary non-specific inflammatory lesion of unknown origin, without signs of infection or demyelinization, in a woman who showed no other evidence of systemic disease.
Conclusions:
Intramedullary lesions that mimick a tumor can be various and difficult to interpret. Preoperative MRI does not allow a certain diagnosis because these lesions have a very similar signal intensity pattern. Specific tests for infective pathologies are useful for diagnosis, but histological examination is essential for establishing a certain diagnosis. In our case the final histological examination and the specific tests that we performed have not cleared our doubts regarding the nature of the lesion that remains controversial.
Case report: VA-ECMO for fulminant myocarditis in an infant with acute COVID-19
Authors: Hao-Ting Hsu, Ni-Chun Kuo, Po-Yen Chen, Sheng-Ling Jan
Journal: Front Pediatr (2023)
Keywords: covid-19, va-ecmo, coronavirus disease 2019, fulminant myocarditis, myocarditis, pediatric
MeSH terms: Case Reports

Fulminant myocarditis in children was rare during the coronavirus disease 2019 pandemic, but it had the potential for high morbidity and mortality. We describe the clinical course of a previously healthy 9-month-old young male infant who rapidly deteriorated into cardiogenic shock due to coronavirus disease 2019-related fulminant myocarditis. He developed severe heart failure and multiple organ dysfunction syndrome that were treated promptly with central venoarterial extracorporeal membrane oxygenation and continuous venovenous hemofiltration. He made a good recovery without significant morbidity.
Type A Aortic Dissection with Antegrade Intimointimal Intussusception
Authors: Christine Lannon, Priya Arunachalam, Lamees I El Nihum, Nina Manian, Amr Telmesani, Qasim Al Abri, Michael J Reardon
Journal: Methodist Debakey Cardiovasc J (2023)
Keywords: intimointimal intussusception, type a aortic dissection
MeSH terms: Aortic Aneurysm, Thoracic / complications, Aortic Aneurysm, Thoracic / diagnostic imaging, Aortic Aneurysm, Thoracic / surgery, Aortic Dissection / complications, Aortic Dissection / diagnostic imaging, Aortic Dissection / surgery, Intussusception, Case Reports, Aorta, Aorta, Thoracic, Humans, Male, Middle Aged, Tomography, X-Ray Computed

We describe a 60-year-old man with a history of hypertension who presented to an outside emergency department with chest pain and left lower extremity numbness and weakness. Computed tomography (CT) revealed Stanford type A aortic dissection (TAAD), and he was transferred to our institution for emergent open surgical repair. Review of the outside CT showed no dissection flap in the ascending aorta and a complex flap in the proximal descending thoracic aorta consistent with complex intimal transection at the sinotubular junction and intimointimal intussusception. This case presents high-resolution diagnostic and intraoperative images and illustrates the importance of rapid diagnosis and recognition of the potentially complex nature of the aortic dissection to avoid impending hemodynamic deterioration.
Treatment of T-Cell Prolymphocytic Leukemia with Central Nervous System Involvement Using Intrathecal Alemtuzumab Administration
Authors: Jinichi Mori, Kumi Oshima, Satoshi Kimura, Takayuki Ikezoe
Journal: Case Rep Hematol (2020)
MeSH terms: Case Reports

T-cell prolymphocytic leukemia (T-PLL) is a rare hematologic cancer with a dismal prognosis. Although a small number of patients have central nervous system (CNS) involvement, a standard treatment approach for these patients has not been established. Herein, we present a case of T-PLL with CNS involvement that was treated with a higher dose of intrathecal alemtuzumab than that previously reported. A 66-year-old man who had T-PLL with CNS involvement was admitted to our hospital. Intravenously administered alemtuzumab, a monoclonal antibody against the CD52 antigen, successfully reduced leukemia cells in peripheral blood; however, intrathecal treatment with methotrexate, cytarabine, and prednisone had a limited effect on the CNS involvement. Therefore, we intrathecally injected alemtuzumab as an experimental treatment. Although we escalated the dose of intrathecal alemtuzumab up to 5 mg, no adverse reaction was noted; however, this treatment did not completely clear the leukemia cells from the patient's cerebrospinal fluid (CSF). We performed whole brain and whole spinal irradiation therapies and subsequently performed allogeneic transplantation from a human leukocyte antigen-matched sibling donor with a conditioning regimen containing total body irradiation. At 21 days after transplantation, leukemia cells remained in his CSF. Although intrathecal alemtuzumab did not eliminate the CNS-invading leukemia cells, it was well-tolerated in our case. Further accumulation of similar cases is needed to determine the benefits and safety of intrathecal alemtuzumab administration.
Pleomorphic Rhabdomyosarcoma Arising from True Vocal Fold of Larynx: Report of a Rare Case and Literature Review
Authors: Sevdegül Mungan, Selçuk Arslan, Eda Küçüktülü, Şafak Ersöz, Bengü Çobanoğlu
Journal: Case Rep Otolaryngol (2016)

We present an extremely rare case of a pleomorphic rhabdomyosarcoma of the true vocal fold. The histopathological diagnosis was confirmed by immunohistochemistry. The patient was treated with radical surgery including total laryngectomy and radical neck dissection followed by postoperative radiotherapy. The clinicopathologic features of this rare malignancy are discussed together with a review of the literature. This case report and literature review highlights the more favorable prognosis of pleomorphic rhabdomyosarcoma in the larynx than in other locations.
The Pathophysiology and Management of Coprophagia: A Report of Two Cases and Literature Review
Authors: Heela Azizi, Tasmia Khan, Cecilia Canale, Jisha Kallikkadan, Ivan Leung, Alexa Kahn, Dina Rimawi, Shantale Williams, Chidubem Matthew Obegolu, Sharon Paul, Shazia Chaudhry, Chiedozie Ojimba, Kodjovi Kodjo, Olaniyi Olayinka, Oluwole Jegede, Ayodeji Jolayemi
Journal: Case Rep Psychiatry (2018)
MeSH terms: Case Reports

Coprophagia is a rare and distressing disorder characterized by symptoms of compulsive consumption of feces. Several attempts have been made in literature to explore the pathophysiology, management, and outcomes of this disorder. However, critical questions remain, related to characterizing effective management, features of associated comorbidities, time to recovery of symptoms, sustainability of recovery, and the determinants of outcomes. Unfortunately, there is a dearth of available literature addressing these questions. We present two cases of patients with coprophagia in seeking to address these questions. Common symptoms of thought content disorder related to coprophagic behavior are noted in both cases. A shorter time to resolution of coprophagia is noted in one of the patients compared to previously reported studies. Recent and pertinent literature was reviewed and the implications for diagnosis and management of coprophagia are discussed.