OpenMed/multicare-articles huggingface dataset:
Multiple dural tuberculomas presenting as leptomeningeal carcinomatosis
Authors: Hasan Kocaeli, Ozgür Taşkapılıoğlu, Elif Başaran, Ahmet Karaoğlu, Ahmet Bekar
Journal: Case Rep Neurol Med (2011)
MeSH terms: Case Reports

Objective and Importance. We present the rare occurrence of multiple dural-based tuberculomas mimicking leptomeningeal carcinomatosis in a young immunocompetent patient. Clinical Presentation. A 36-year-old man presented with a 2-month history of generalized epileptic activity and altered perception. Neurological examination was remarkable for bilateral Babinski's sign. Cranial magnetic resonance imaging (MRI) revealed multiple dural-based enhancing lesions with cerebral edema. Intervention. A right frontal craniotomy was performed for diagnosis. Histological examination revealed multiple confluent necrotizing and nonnecrotizing granulomas with giant cells which was consistent with tuberculosis (TB), and the patient was placed on anti-TB therapy for 24 months. Conclusion. To the best of our knowledge isolated diffuse involvement of the dura mater by TB, mimicking leptomeningeal carcinomatosis, as the sole manifestation of disease has not been reported before. Since pachymeningeal TB is rarely suspected when atypical radiological appearance is combined with the absence of systemic disease, biopsy is inevitably required for diagnosis.
Macroglossia Associated With Clobazam Administration: A Case Report and Literature Review
Authors: Jeff F Zhang, Kevin Nickerson, Ravi Piryani, Osman Farooq, Anil K Swayampakula
Journal: Front Neurol (2022)
Keywords: clobazam, antiseizure drug, epilepsy, macroglossia, pediatric neurology
MeSH terms: Case Reports

Clobazam is a benzodiazepine derivative used as an antiepileptic agent for the treatment of focal and generalized seizures and drug-resistant epilepsy associated with Lennox-Gastaut Syndrome. While somnolence and mood-related side effects are commonly observed, acute macroglossia following initiation of Clobazam therapy has not been previously reported in the medical literature. In this case report, we present a female pediatric patient who developed significant tongue swelling with protrusion beyond the oral cavity after initiation of Clobazam for treatment-resistant epilepsy. Symptoms were unresponsive to antihistamines and steroids but resolved gradually in the days following discontinuation of Clobazam with no lingering sequelae.
An Acute Ibuprofen Overdose Masking a Severe Staphylococcus aureus Meningitis: A Case Report
Authors: Matthew Smetana, Katy Picard, Kevin M Boehm
Journal: Case Rep Emerg Med (2013)

Acute bacterial meningitis has a low incidence (3/100,000 in the United States) and yet high fatality rate (approximately 14-16%) and classically presents as a triad of fever, neck stiffness, and altered mental status. However, less than half of patients with meningitis present with this classic triad. We present the clinical course of a patient who initially presented to the emergency department after overdosing on ibuprofen for what he described as back pain secondary to mechanical injury. However, the patient's condition quickly deteriorated: he developed tachycardia, mental status changes, was intubated due to respiratory distress, and then suffered an 8-minute PEA arrest before return of spontaneous circulation was achieved. After the patient was stabilized, in addition to the nonsteroidal anti-inflammatory drug (NSAID) overdose Staphylococcus aureus meningitis, bacteremia, and pneumonia were diagnosed. We report this case to illustrate that the initial presentation of meningitis may be extremely unusual especially in the setting of NSAID overdose and the acutely decompensating patient. As the risk of adverse clinical outcomes increases with delays in appropriate antibiotic therapy, it is therefore crucial to recognize the many signs and symptoms of meningitis, typical and atypical, and quickly begin appropriate treatment.
Transcallosal Removal of a Choroid Plexus Tumor From the Lateral Ventricle in a Dog. Case Report
Authors: László Lehner, Kálmán Czeibert, Judit Benczik, Csaba Jakab, Gábor Nagy
Journal: Front Vet Sci (2020)
Keywords: choroid plexus tumor, dog, lateral ventricle, papilloma, surgery
MeSH terms: Case Reports

A 6-years-old female Staffordshire terrier was referred for periodic generalized seizures and asymmetric visual deficits. Magnetic resonance imaging revealed a 23.2 × 19.3 × 23.0 mm soft tissue mass within the right lateral ventricle and consequential dilatation of the lateral ventricles. Surgically, an interhemispheric approach was performed next to the marginal gyrus after a right parieto-parasagittal craniotomy, and a large choroid plexus tumor was transcallosally removed. After 3 days, the dog was discharged to home, and supportive treatment was continued. Histology revealed a choroid plexus papilloma, which was also confirmed by immunohistochemistry. One month after surgery, a control MRI showed that the ventricles were still dilated, but there was no sign of recurrent tumor. The dog had two additional seizures at home during the month following the intervention and one more grand mal episode was observed 4 months after the surgery. Nine months after the surgery, the dog showed no seizure activity, but her vision had not yet returned.
Prevention of Fascial Retraction in the Open Abdomen with a Novel Device
Authors: Anita Hees, Frank Willeke
Journal: Case Rep Surg (2020)
MeSH terms: Case Reports

The open abdomen requires intensive and specific treatment efforts. Long hospital admissions, treatment duration, high mortality rates, deferred and delayed wound closures with alloplastic materials or elaborate closure techniques, and the need for subsequent surgical procedures justify and call for implementation of new therapy options. The case presented here demonstrates the use of a new product (Fasciotens Abdomen) to prevent fascial retraction in the open abdomen of an extubated, conscious patient with four-quadrant peritonitis after perforated appendicitis. Controlled, anteriorly directed fascial traction of 50-60 Newtons prevented fascial retraction during open treatment of the abdomen. Once edema was reduced, abdominal closure was completed without difficulty. This new form of therapy was well tolerated by the patient and led to a markedly more rapid abdominal closure without mesh or abdominal wall reconstruction.
Changes in the Foveal Outer Nuclear Layer of Central Serous Chorioretinopathy Patients Over the Disease Course and Their Response to Photodynamic Therapy
Authors: Kaixin Deng, Yufei Gui, Yi Cai, Zhiqiao Liang, Xuan Shi, Yaoyao Sun, Mingwei Zhao
Journal: Front Med (Lausanne) (2022)
Keywords: oct, central serous chorioretinopathy, disease duration, outer nuclear layer, photodynamic therapy

Objective:
To investigate the association between foveal outer nuclear layer (ONL) thickness and the natural course of central serous chorioretinopathy (CSC), as well as the thickness change after photodynamic therapy (PDT), exploring the PDT timing for CSC.
Methods:
This retrospective consecutive case series included 358 CSC patients between January 2014 and December 2019. All patients were divided into four groups depending on disease duration: Group A: ≤1 month; Group B: >1 and ≤3 months; Group C: >3 and≤6 months and Group D: >6 months. Foveal ONL thickness of the CSC eye and the clinically healthy fellow eye were measured and compared in all patients. Fifty-six patients were successfully treated with half-dose of PDT, showing complete subretinal fluid absorption, were followed up for more than 6 months and further investigated. The recovery of foveal ONL thickness was analyzed in the affected eyes of patients with different disease duration.
Results:
No significant reduction was found in CSC foveal ONL thickness (μm) compared to the fellow eye in patients with disease duration less than 1 week (112.3 ± 12.2 vs. 116.7 ± 15.3, P = 0.268). Patients with longer disease duration had varying degrees of ONL thinning compared to the contralateral eye (all P < 0.05) and this difference was more pronounced in patients with disease duration greater than 6 months (75.8 ± 12.9 vs. 113.0 ± 11.5, P < 0.001). At 6-month follow-up after PDT, foveal ONL thickness of patients with <1 month disease duration recovered significantly from onset (97.3 ± 18.2 to 113.6 ± 8.7, P < 0.001) and became similar to that of the healthy fellow eye. Foveal ONL thickness of patients with duration>1 and≤3 months recovered significantly (88.5 ± 11.5 to 95.8 ± 11.3, P = 0.012) but remained thinner than that of the healthy fellow eye. Foveal ONL thickness did not improve significantly in cases with disease duration longer than 3 months (P > 0.05).
Conclusion:
Foveal ONL thinning was positively associated with disease duration prior to treatment suggesting that longer disease duration limits scope for foveal ONL recovery. CSC patients should be treated with PDT as soon as possible to prevent disease development and reduced visual function.
A case series of negative pressure wound therapy as a promising treatment in patients with burn injury
Authors: M Rosadi Seswandhana, Sharfan Anzhari, Ishandono Dachlan, Yohanes Widodo Wirohadidjojo, Teguh Aryandono
Journal: Int J Surg Case Rep (2020)
Keywords: burn dressing, burn treatment, burns, npwt, negative pressure wound therapy

Introduction:
Burn injuries continue to be a global burden. Burn wound treatment often requires a long treatment time and often results in high morbidity and mortality. Until now, there is still no ideal burn wound treatment for all patients.
Presentation of cases:
Here we report 3 cases of burn patients. Every patient underwent wound debridement and followed by installation of Negative Pressure Wound Therapy (NPWT) on the site of burn injuries. All of patients was discharged in a good condition.
Discussion:
NPWT is an application of sub-atmospheric pressure that is placed on the wound. Today, the use of negative pressure therapy is a new strategy in managing burn injuries. NPWT can reduce the length of stay of burn patients that can be associated with faster wound healing, and reduce bacterial levels in burns.
Conclusion:
The combination of debridement and NPWT in burn patients can be an alternative procedure because it can promote faster wound healing and reduce the length of hospitalization. Furthermore, this is the first report of NPWT usage for the treatment of burn patients in Indonesia.
Case Report: Isolated Lingual Dystonia
Authors: Zaland Ahmed Yousafzai, Wajeeha Qayyum, Sohail Khan, Mawara Iftikhar, Qazi Kamran Amin
Journal: F1000Res (2020)
Keywords: dystonia, focal dystonia, isolated dystonia, lingual dystonia, neurology, oromandibular dystonai
MeSH terms: Dystonic Disorders / diagnosis, Case Reports, Adult, Female, Humans, Magnetic Resonance Imaging, Tongue / physiopathology

Oromandibular dystonia is defined as a focal dystonia that manifests as forceful contractions of the face, jaw, and/or tongue. Lingual dystonia is a rare subtype of oromandibular dystonia that specifically affects the tongue. Multiple etiologies are thought to attribute to oromandibular dystonia, including brain damage, the use of neuroleptic medications, neurodegenerative disorders, metabolic disorders, neurodevelopmental disorders, and viral infections. Idiopathic cases of isolated lingual dystonia are rare and seldom reported in the literature. This report describes a 35-year-old female patient with lingual dystonia that was present at rest and aggravated during speech. Despite detailed history taking and a thorough examination, along with multiple imaging and laboratory studies, no cause could be established and her case was classified as being that of an idiopathic etiology.
Management of a nine litre abdominal wall seroma post ventral hernia repairs: A case report
Authors: Danika Jurat, Parveen Kumar, Kim Goddard
Journal: Int J Surg Case Rep (2020)
Keywords: case report, mesh repair, partial capsulectomy, scarification, seroma, ventral wall hernia
MeSH terms: Case Reports

Introduction:
seromas are a common and challenging complication post mesh hernia repairs (Morales-Conde, 2012; Salamone, 2015; Vasilakis, 2014).
Presentation of case:
A 52-year-old male was referred to General Surgery with a large abdominal mass in the setting of morbid obesity and multiple abdominal operations culminating in a ventral hernia repair seven years prior. He had no other abdominal symptoms or malignancy red flags. Imaging demonstrated a large, complex anterior abdominal wall seroma of 40 × 25 × 20 cm. No seromas of this size and location have been reported in the literature.
Discussion:
Surgical management required drainage, partial capsulectomy and scarification of the remnants with multidisciplinary team involvement for recovery including general surgeons, anaesthesia, intensivists and allied health professionals.
Conclusion:
The patient recovered well from his operation.
Hemoptysis following Talc Pleurodesis in a Pneumothorax Patient
Authors: Yusuke Kakiuchi, Fumihiro Yamaguchi, Makoto Hayashi, Yusuke Shikama
Journal: Case Rep Pulmonol (2017)
MeSH terms: Case Reports

The purpose of this article is to report a case of hemoptysis occurring in combination with secondary spontaneous pneumothorax following chemical pleurodesis by talc. A Japanese male with cancer of renal pelvis was found with the left pneumothorax and multiple lung metastases. A computed-tomography scan revealed severe emphysema throughout the lungs. Talc pleurodesis was employed to arrest air leakage. The patient developed hemoptysis 45 minutes after talc injection into the thorax. This is the first report of hemoptysis following talc pleurodesis. The agent could induce severe inflammation in capillary vessels of the lung following visceral pleura infiltration.
Dystrophic Myopathy of the Diaphragm with Recurrent Severe Respiratory Failure is Congenital Myasthenic Syndrome 11
Authors: J J Kramer, H T M Boon, Q H Leijten, Henk Ter Laak, L Eshuis, B Kusters, J L M van Doorn, E J Kamsteeg, B Eymard, J Doorduin, N C Voermans
Journal: J Neuromuscul Dis (2023)
Keywords: cms11, congenital myasthenic syndrome, rapsn, rapsyn, whole exome sequencing, diaphragmatic dystrophy
MeSH terms: Muscular Dystrophies, Myasthenic Syndromes, Congenital / genetics, Case Reports, Diaphragm, Humans, Male, Mutation, Quality of Life

We here present the case of a patient with a congenital myasthenic syndrome (CMS) due to pathogenic variants in the RAPSN gene. During childhood he experienced recurrent episodes of respiratory failure during respiratory infections. This and other cases were reported as isolated dystrophy of the diaphragmatic musculature. In adulthood, whole exome sequencing revealed two heterozygous pathogenic variants in the RAPSN gene. This led to the revision of the diagnosis to rapsyn CMS11 (OMIM:616326, MONDO:0014588). EMG, muscle ultrasound and the revision of muscle biopsies taken in childhood support this diagnosis. After the revision of the diagnosis, treatment with pyridostigmine was started. This resulted in a reduction of fatigability and an improvement in functional abilities and quality of life.
Rural South Africans' rehabilitation experiences: Case studies from the Northern Cape Province
Authors: Surona Visagie, Leslie Swartz
Journal: S Afr J Physiother (2016)

Background:
Rehabilitation is often challenging in South Africa, but South Africans living in remote rural settings might experience unique challenges.
Objective:
This article interrogates issues of access to rehabilitation in a selected sample from rural South Africa through case studies.
Method:
This qualitative study utilised a case study design. Eight case studies were done in a purposively sampled rural town in the Northern Cape Province. Data were collected through in-depth interviews. Data were analysed according to the principles of interpretative phenomenological analysis.
Results:
The case study participants were not integrated into the community. They experienced higher levels of disability than one would expect from their impairments. Their impairments were not modified. No retraining of function was implemented. Early intervention and childhood development activities were not provided. Participants were not linked with self-help or peer support groups. Provision of assistive devices was challenged. Environmental barriers aggravated the situation.
Conclusion:
We theorise that one-on-one therapy is not the solution to the rehabilitation needs of persons with disabilities in remote, rural settings. We recommend a move to community-based rehabilitation and transdisciplinary teamwork supported by family members, community health workers and peer mentors. Therapists are ideally situated to explore the feasibility of such programmes and to pilot them in various communities.
Laboratory-acquired dengue virus infection by needlestick injury: a case report, South Korea, 2014
Authors: Changhwan Lee, Eun Jung Jang, Donghyok Kwon, Heun Choi, Jung Wan Park, Geun-Ryang Bae
Journal: Ann Occup Environ Med (2016)
Keywords: dengue, laboratories, needlestick injuries
MeSH terms: Case Reports

Background:
Dengue fever is one of the most dominant vector-borne diseases, putting approximately 3.9 billion people at risk worldwide. While it is generally vector-borne, other routes of transmission such as needlestick injury are possible. Laboratory workers can be exposed to dengue virus transcutaneously by needlestick injury. This is the first case, to our knowledge, of dengue virus infection by needlestick injury in a laboratory environment. This paper evaluates the risk and related health concerns of laboratory workers exposed to dengue virus.
Case presentation:
We evaluated a 30-year-old female laboratory worker exposed to the dengue virus by needlestick injury while conducting virus filtering. During admission, she showed symptoms of fever, nausea, myalgia, and a characteristic maculopapular rash with elevated aspartate aminotransferase (AST) of 235 IU/L and alanine aminotransferase (ALT) of 269 IU/L. She had been diagnosed by a positive nonstructural protein 1 (NS1) antigen (Ag) rapid test one day prior to symptom onset along with positive immunoglobulin M (IgM) enzyme-linked immunosorbent assay (ELISA) on the ninth day of symptom onset. Reverse transcription polymerase chain reaction (RT-PCR), also conducted on the ninth day, was negative. After proper symptomatic treatment, she recovered without any sequelae. As a result of thorough epidemiologic investigation, it was determined that she had tried to recap the needle during the virus filtering procedure and a subsequent needlestick injury occurred.
Conclusions:
In the context of health promotion of laboratory workers, we suggest that the laboratory biosafety manual be revised and reinforced, and related prevention measures be implemented. Furthermore, health authorities and health care providers in Korea should be fully informed of proper dengue fever management.
A Rare Case of Renal Infarct due to Noncompaction Cardiomyopathy: A Case Report and Literature Review
Authors: Karan Wats, On Chen, Nupur Nippun Uppal, Syeda Atiqa Batul, Norbert Moskovits, Vijay Shetty, Jacob Shani
Journal: Case Rep Cardiol (2016)

Left ventricular noncompaction cardiomyopathy is a rare myocardial disorder which results from failure of left ventricle to compact in embryogenesis. We present a case of a 53-year-old female who came because of abdominal pain and was found to have renal infarct secondary to noncompaction cardiomyopathy.
Carcinosarcoma of the Gallbladder with Chondrosarcomatous Differentiation and Intracytoplasmic Eosinophilic Hyaline Globules (Thanatosomes): A Report of a Case and Review of the Literature
Authors: Jumana A Alratroot, Amani A Joudeh, Samir S Amr
Journal: Case Rep Pathol (2019)
MeSH terms: Case Reports

A 52-year-old woman presented with abdominal pain and vomiting. Computed tomography (CT) scan of the abdomen revealed a huge exophytic gallbladder mass displacing or invading the surrounding structures. The patient underwent radical cholecystectomy, transverse colectomy, distal gastrectomy, and liver bed resection. Histologically, the tumor showed both carcinomatous and sarcomatous components, with prominent chondrosarcomatous differentiation. In addition, several malignant cells showed intracytoplasmic eosinophilic hyaline globules (Thanatosomes). The tumor showed metastatic deposits to the omentum, the liver, and the peripancreatic lymph nodes. We report this unusual case and present a review of all cases of carcinosarcoma of the gallbladder with chondrosarcomatous differentiation.
Mantle Cell Lymphoma in the Thyroid: A Rare Presentation
Authors: Uzma Mohammad Siddiqui, Sarika N Rao, Pallavi Kanwar Galera, Nahida Islam, Mira S Torres
Journal: Case Rep Pathol (2017)
MeSH terms: Case Reports

Background:
While 2% of all extranodal Non-Hodgkin Lymphomas present in the thyroid, there exists insufficient data to describe the incidence of mantle cell lymphoma in the thyroid. A case series of 1400 patients revealed that <1% of thyroid lymphomas may be MCL; hence better understanding of the disease course is essential.
Patient findings:
A 65-year-old female was referred for a multinodular goiter. Multiple fine needle aspirations from the dominant right nodule were consistent with Hashimoto's thyroiditis and flow cytometry was negative. Due to progressing dysphagia, she underwent total thyroidectomy.
Summary:
Pathology revealed MCL with mantle zone growth pattern in the right thyroid. Flow cytometry showed monoclonal B cells comprising 9% of total cells. The Ki-67 index was 10%. She was diagnosed as having stage IIE MCL and offered conservative management by medical oncology, given that she had no B symptoms.
Conclusion:
Though chemotherapy is the treatment of choice in MCL, a subset of patients with low-grade disease may be observed. As in our patient, mantle zone growth pattern and a Ki-67 index < 10% suggest a favorable prognosis. A diagnosis of primary MCL in the thyroid remains rare and staging modalities as well as treatment options continue to evolve.
SAPHO Syndrome Masquerading as Metastatic Breast Cancer
Authors: Devin Malik, Richa Handa, Andrew Petraszko, Sheela Tejwani
Journal: Case Rep Rheumatol (2018)
MeSH terms: Case Reports

SAPHO syndrome is a rare clinical entity composed of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO). We describe a case of SAPHO syndrome masquerading as metastatic breast cancer in a patient with localized breast cancer who presented with cord compression. There was no pathologic evidence of metastatic cancer; however, a bone scan indicated osseous involvement. After multidisciplinary review of images and with additional findings of pustulosis and acne, a clinical diagnosis of SAPHO was made.
Rare Benign Large Lymphoid Colonic Polyp
Authors: Yousef Alshamali, Ahmad Al Taleb, Talal Al-Taweel
Journal: Case Rep Gastrointest Med (2018)
MeSH terms: Case Reports

Benign lymphoid polyps are uncommon lesions of the small bowel and the colon to a lesser degree that are mostly found in children. There are only few reported cases in adults in which the lesions were predominantly polypoid and described as lymphonodular hyperplasia. We present a case of a large benign lymphoid polyp in the transverse colon of a 64-year-old lady who was referred to our care for a history of alteration in her bowel habit and anemia. Colonoscopy showed a 3 cm (Paris 1p) friable polyp which was excised and retrieved. Histopathology examination confirmed its benign nature supported by immunohistochemical studies. Benign lymphoid polyp is a rare condition posing a diagnostic challenge as it can be misinterpreted as a malignant lesion.