OpenMed/multicare-articles huggingface dataset:
Andes virus and first case report of Bermejo virus causing fatal pulmonary syndrome
Authors: Paula Padula, Marcelo González Della Valle, María Garcia Alai, Pedro Cortada, Mario Villagra, Alberto Gianella
Journal: Emerg Infect Dis (2002)
MeSH terms: Hantavirus Pulmonary Syndrome / virology, Orthohantavirus / isolation & purification, Case Reports, Adult, Bolivia, Fatal Outcome, Hantavirus Pulmonary Syndrome / diagnosis, Humans, Male, Middle Aged, Orthohantavirus / genetics, Risk Factors, Sequence Analysis, DNA

Two suspected hantavirus pulmonary syndrome (HPS) cases from Bolivia occurred in May and July 2000 and were confirmed by enzyme-linked immunosorbent assay (ELISA)-ANDES using N-Andes recombinant antigen serology. Clot RNAs from the two patients were subjected to reverse transcription-polymerase chain reaction (PCR) amplification and sequencing. We describe two characterized cases of HPS. One was caused by infection with Bermejo virus and the other with Andes Nort viral lineage, both previously obtained from Oligoryzomys species. This is the first report of molecular identification of a human hantavirus associated with Bermejo virus.
Case report: Recurrent nocturnal awakenings in cluster headache: a different type of ghost attack
Authors: Giada Giuliani, Maurizio Gorgoni, Marta Altieri, Vittorio Di Piero
Journal: Front Neurol (2023)
Keywords: cluster headache, ghost attacks, nocturnal awakenings, prophylactic treatment, verapamil
MeSH terms: Case Reports

Introduction:
Cluster headache (CH) is a trigeminal autonomic cephalalgia characterized by attacks of severe unilateral pain associated with ipsilateral autonomic symptoms. Cluster headache attacks exhibit nocturnal predilection, and sleep disorders could be the first manifestation of an incipient cluster period. Sleep alterations in cluster headache patients may reflect the pivotal role of the hypothalamus, which is crucially involved in the pathophysiology of this primary headache. We describe the case of a patient affected by episodic cluster headache who experienced a sleep disorder after starting therapy with verapamil.
Case presentation:
A 47-year-old man was affected by episodic cluster headache, characterized by attacks of excruciating pain in the left orbital and temporal regions, associated with prominent ipsilateral vegetative symptoms. Headaches occurred during the night, with one or two nocturnal attacks appearing at 11.30-12 p.m. and 4-4.30 a.m. Preventive treatment with verapamil was started, with immediate pain relief. Later, he experienced consecutive nocturnal awakenings for a couple of weeks, always at the same time, without any pain or autonomic symptoms. He was not agitated and did not need to get out of bed; after the awakenings, he reported sleep disturbances with vivid dreams.
Discussion and conclusion:
This case represents the first description of recurrent cyclic nocturnal awakenings, without pain and autonomic symptoms, in a patient with episodic cluster headache during the active phase of a cluster bout. Nocturnal awakenings, started after the introduction of effective preventive therapy, might be an unusual form of "ghost attacks." After the beginning of prophylactic therapy, patients often describe mild pain or localized pressure in the same localization of CH attack. Similarly, the appearance of sleep disturbances, without any pain or vegetative symptoms, should be regarded as a warning sign of a still active cluster bout. Since these manifestations may influence therapeutic management, they should be carefully investigated.
Case report: Transcatheter edge-to-edge repair after prior surgical tricuspid annuloplasty
Authors: Shazia Afzal, Jafer Haschemi, Florian Bönner, Malte Kelm, Patrick Horn
Journal: Front Cardiovasc Med (2022)
Keywords: triclip, annuloplasty, percutaneous, surgery, tricuspid regurgitation
MeSH terms: Case Reports

Residual and recurrent tricuspid regurgitation may occur frequently after surgical tricuspid valve repair. However, reoperation for tricuspid regurgitation is rare, although many patients are again highly symptomatic. Tricuspid transcatheter edge-to-edge repair (TEER) is a promising therapy for severe tricuspid regurgitation. Herein, we report a 77-year-old woman with recurrent symptomatic massive tricuspid regurgitation 2 years after sutured annuloplasty of the tricuspid valve. TEER was successfully performed using the TriClip® device and tricuspid regurgitation was reduced to a mild degree. In conclusion, tricuspid TEER is feasible following surgical suture annuloplasty. TEER is an alternative option for patients with a failed previous annuloplasty repair for tricuspid regurgitation to undergo a less invasive treatment rather than a potentially higher-risk reoperation.
Acute ulnar nerve compression associated with pisiform fracture - a case report and literature review
Authors: Min Kai Chang, Robert Tze Jin Yap
Journal: Case Reports Plast Surg Hand Surg (2019)
Keywords: carpal, guyon’s canal, fracture, pisiform, pisiformectomy, ulnar nerve
MeSH terms: Case Reports

We evaluated a case of pisiform fracture with ulnar nerve compression managed with pisiformectomy. At 11 months' follow-up, the patient regained range of motion of the wrist and grip strength with no subjective loss of function and normal nerve conduction study. We compared other treatment modalities and reviewed their outcomes.
Carfilzomib-Induced Tumor Lysis Syndrome and Biventricular Heart Failure in a Patient With Multiple Myeloma
Authors: Farhan Azad, Ross Moyer, Clive J Miranda, Matthew Gravina
Journal: Cureus (2023)
Keywords: bortezomib, carfilzomib, multiple myeloma, proteasome, tls, tumor lysis syndrome
MeSH terms: Case Reports

Carfilzomib is a proteasome inhibitor (PI) used in multiple myeloma (MM) that is resistant to other therapies. Despite its efficacy and potency, carfilzomib has been associated with kidney injuries, cardiovascular toxic effects, and hematological adverse events. Tumor lysis syndrome (TLS) following the use of PIs in MM, a malignancy not known to cause TLS, has seldom been reported. We present a case of a patient with a known diagnosis of MM who received prior therapy including bortezomib, a first-generation PI, developing worsening heart failure and new onset TLS days after the administration of carfilzomib.
Severe Wound Infection with Photobacterium damselae ssp. damselae and Vibrio harveyi, following a Laceration Injury in Marine Environment: A Case Report and Review of the Literature
Authors: Jörg Hundenborn, Steffi Thurig, Mechthild Kommerell, Heike Haag, Oliver Nolte
Journal: Case Rep Med (2013)

Marine microorganisms are uncommon etiologies of skin and skin structure infections, that is, wound infections. We report a case of severe wound infection, caused by the marine Photobacterium damselae (Vibrionaceae), in a 64-year-old male patient, returning from Australia. The isolate tested positive for pPHDD1, a plasmid conferring high-level virulence. Furthermore, the wound was coinfected with Vibrio harveyi, a halophile bacterium, which has never been reported from human infections before. Identification was achieved by use of Matrix-Assisted Laser Desorption-Ionization Time of Flight Mass Spectrometry (MALDI-TOF) and confirmed by 16S rDNA sequencing. Data retrieval from bibliography was complicated since P. damselae has been renamed often with a number of synonyms present in the literature: Photobacterium damsela, Vibrio damselae, Vibrio damsela, Pasteurella damselae, and Listonella damsela. With all synonyms used as query terms, a literature search provided less than 20 cases published worldwide. A majority of those cases presenting as severe wound infection are even fatal following progression into necrotizing fasciitis. Management with daily wound dressing and antibiotic therapy (ofloxacin empirically, followed by doxycycline after availability of microbiology) led in the reported case to a favorable outcome, which seems to be, however, the exception based on a review of the available literature.
Bilateral Sturge-Weber and Phakomatosis Pigmentovascularis with Glaucoma, an Overlap Syndrome
Authors: Bharat Patil, Gautam Sinha, Bhagabat Nayak, Reetika Sharma, Sadhana Kumari, Tanuj Dada
Journal: Case Rep Ophthalmol Med (2015)

Aim. To report a case of bilateral Sturge-Weber and Phakomatosis pigmentovascularis with secondary glaucoma in a child. Method.
Case report:
Results. A 4-year-old male child was referred to us for control of intraocular pressure (IOP). Sleeping IOP was 36 mm Hg in right eye and 28 mm Hg in the left eye. The sclera of both the eyes showed bluish black pigmentation-melanosis bulbi. Fundus examination of both eyes showed diffuse choroidal hemangiomas with glaucomatous cupping. Nevus flammeus was present on both sides of face along all the 3 divisions of trigeminal nerve with overlying hypertrophy of skin and on left forearm. Nevus fuscocaeruleus was present on upper trunk. All skin lesions were present since birth and were stationary in nature. CT scan of head revealed left-sided cerebral atrophy. Intraocular pressure was controlled after treatment with topical antiglaucoma medications. Pulsed Dye Laser has been advised by dermatologist for skin lesions. Patient has been advised for regular follow-up. Conclusion. The two overlapping dermatological disorders and their association with glaucoma are a rare entity. Management should be targeted both for dermatological and eye conditions.
QT interval prolongation after sertraline overdose: a case report
Authors: Rudolf A de Boer, Tonnis H van Dijk, Nicole D Holman, Joost P van Melle
Journal: BMC Emerg Med (2005)

Background:
Selective serotonin reuptake inhibitors (SSRIs) are the most common antidepressants used in first-world countries and are generally well tolerated. Specifically, less cardiovascular toxicity has been reported in comparison with tricyclic antidepressants. Here we report QT interval prolongation after an overdose of the SSRI sertraline.
Case presentation:
A previously healthy female patient presented with an attempted suicide with overdoses sertraline (2250 mg), diazepam (200 mg), and temazepam (400 mg). Routine laboratory studies were normal and her ECG upon admission showed a normal QT interval. The next day, her ECG showed prolongation of the QTc interval up to 525 ms. After discontinuation of sertraline the QT interval normalized. Echocardiography and exercise electrocardiography were normal. After hospitalization, the patient resumed sertraline in the normally recommended dose and QT interval remained within normal ranges.
Conclusion:
It seems that the SSRI sertraline in overdose may cause QT interval prolongation.
Laugier-Hunziker Syndrome in an 8-Year-Old Boy with Scleral Melanocytosis, Lingual Pigmentation, Labial Pigmentation, and Melanonychia Striata
Authors: Alexander K C Leung, Kin Fon Leong, Benjamin Barankin, Joseph M Lam
Journal: Case Rep Pediatr (2020)
MeSH terms: Case Reports

Laugier-Hunziker syndrome is a rare, acquired disorder characterized by mucocutaneous hyperpigmentation and melanonychia striata with no underlying systemic abnormalities. We report an 8-year-old boy with Laugier-Hunziker syndrome who presented with melanonychia striata affecting all the fingernails and toenails, macular pigmentation on the tongue and the lower lip, and scleral melanocytosis. Melanonychia striata rarely affect all the twenty nails, and scleral melanocytosis has rarely been reported in association with Laugier-Hunziker syndrome. Laugier-Hunziker syndrome occurs predominately in adults. Our patient is the youngest reported patient with Laugier-Hunziker syndrome.
Massive hematochezia: a complication of methamphetamine-induced vasculitis treated by transcatheter hemostasis
Authors: Daniel P Link, Yung-Wei Chi
Journal: Case Rep Radiol (2011)
MeSH terms: Case Reports

A long-term, heavy methamphetamine user with life-threatening rectal hemorrhage was treated with transcatheter occlusion of the bleeding arteries. The bleeding blood vessels were vulnerable submucosal arteries, part of the collateral supply to the distal colon. Visceral arteriography demonstrates severe arterial stenotic lesions of the celiac axis, superior mesenteric artery and the inferior mesenteric artery. Collateral vessels were seen with corkscrew morphology similar to that seen with thromboangiitis obliterans.
Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy
Authors: Dahlene N Fusco, Lilia Ganova-Raeva, Yury Khudyakov, Lili Punkova, Aisha Mohamed, Scarlett Se Yun Cheon, Prapti Koirala, Karin L Andersson, Gonzague Jourdain, Camille Sureau, Raymond T Chung, Georg Lauer
Journal: Front Med (Lausanne) (2018)
Keywords: hbv vaccine escape mutant, hcv, hepatitis b virus, pres2 deletion, surface antibody escape mutant
MeSH terms: Case Reports

A 76-year-old Cambodian man co-infected with hepatitis B virus (HBV) and hepatitis C virus (HCV) 6c-1 presented for care. HBV DNA was intermittently detectable despite anti-HBs levels being above the protective threshold. During treatment for HCV, HBV DNA levels increased. Sequencing revealed multiple mutations including vaccine escape mutation and mutations predicted to enhance fitness. This case represents exacerbation of an HBV vaccine escape mutant during a direct-acting antiviral therapy.
Rhino-orbito-cerebral mucormycosis in patients with uncontrolled diabetes: A case series
Authors: Fatimah Al Hassan, Marwah Aljahli, Fadel Molani, Ali Almomen
Journal: Int J Surg Case Rep (2020)
Keywords: diabetes mellitus, mucorales, mucormycosis, paranasal sinuses, zygomycosis

Introduction:
Mucormycosis is a rare, aggressive, and invasive disease with a fatal outcome. It most commonly affects patients with compromised immunity, particularly those with poorly controlled diabetes. We present a case series of patients with uncontrolled diabetes and mucormycosis.
Presentation of case:
We present a series of three patients with uncontrolled diabetes, with main symptoms of paranasal sinusitis, nasal discharge, ophthalmic changes, and facial nerve involvement. Diagnoses of mucormycosis were made via microbiological testing and computed tomography. These cases were managed by combination therapy of tight glycemic control, urgent endoscopic sinus debridement, and antifungal therapy.
Discussion:
Diagnosing rhino-orbito-cerebral mucormycosis requires a high degree of suspicion and both microbiologic and microscopic evidence. Better clinical outcomes can be obtained by combining medical and surgical management.
Conclusion:
We describe our experience in handling three cases of poorly controlled diabetes with rhino-orbito-cerebral mucormycosis.
Alagille Syndrome: A Novel Mutation in JAG1 Gene
Authors: Rita Fischetto, Viviana V Palmieri, Maria E Tripaldi, Alberto Gaeta, Angela Michelucci, Maurizio Delvecchio, Ruggiero Francavilla, Paola Giordano
Journal: Front Pediatr (2019)
Keywords: alagille syndrome, jag1, next generation sequencing, hypertransaminasemia, stop codon mutation
MeSH terms: Case Reports

Alagille syndrome is an autosomal dominant multisystem disorder with variable phenotypic penetrance, caused by heterozygous mutations in JAG1 or NOTCH2, encoding for the components of the Notch signaling pathway. In this paper, we described a novel mutation not yet reported in literature. This 3-years old male child was referred to our Clinical Genetics Unit because of delayed psychomotor development, systolic murmur, dysmorphic facial features, and hypertransaminasemia. The novel JAG1 heterozygous c.2026delT variant in exon 16 was found. JAG1 mutations are classified as protein truncating and non-protein truncating, without any genotype-phenotype correlation. The detected mutation determines a stop codon (p.Cys676AlafsTer67) in the gene sequence, encoding a truncated protein. Our report broadens the spectrum of JAG1 gene mutations.
An Extremely Rare Presentation of Four Coronary Anomaly Patterns Originating from the Right Coronary Sinus
Authors: Nabil Braiteh, Wajeeh Rehman, Wajiha Ali, Owais Ahmed
Journal: Case Rep Cardiol (2022)
MeSH terms: Case Reports

Background:
"Coronary anomaly" is defined as the coronary feature or pattern seen in <1% of the population. The most common CAAs are anomalies of origin, specifically having a separate LCX and LAD origin with an incidence of 0.41%. The second most common anomaly is the LCX arising from the RCA (0.37%). Treatment options include CABG, coronary unroofing, reimplantation, or medical therapy. Case Presentation. We present the case of an 85-year-old male who presents with an acute coronary syndrome who was found to have an extremely rare combination of different coronary anomaly patterns including left main coronary artery (LMCA) atresia, small LAD arising posteriorly from the right coronary cusp, anomalous left circumflex artery arising from the RCA, and an anomalous LAD arising from the left circumflex artery which is originating from the RCA.
Conclusions:
To the best of our knowledge, this is the first case report to describe four coronary anomalies in a single patient. When CAAs are diagnosed, it is of utmost importance for cardiologists to do further imaging and workup that might include a stress test to be able to offer patients the best management options.
Extravasation of fluid in arthroscopic shoulder surgery requiring prolonged intubation: a case report
Authors: Brandon R Vier, Kyle W Mombell, Erin L Gagliano, Nicole M King, Lucas S McDonald
Journal: Patient Saf Surg (2019)
Keywords: airway, arthroscopy, fluid extravasation, shoulder
MeSH terms: Case Reports

Background:
Shoulder arthroscopy is a safe and effective procedure with a low complication rate. Although rare, there are potentially life-threatening risks such as fluid extravasation causing airway compromise.
Case presentation:
We report the case of a 65-year-old female treated with an arthroscopic rotator cuff repair who had significant extravasation of arthroscopic fluid causing severe facial and neck swelling. Overnight intubation was required for respiratory monitoring until the edema had resolved enough to allow safe extubation.
Conclusion:
This case highlights the risk factors and clinical course of a patient with airway compromise caused by extravasation of fluid during shoulder arthroscopy. Although shoulder arthroscopy is a safe procedure, surgeon familiarity with the risk factors for this complication and close monitoring can aid in its identification and allow for appropriate treatment.
Spinal arteriovenous fistula coexisting within a spinal lipoma: report of two cases
Authors: Yosuke Horiuchi, Akio Iwanami, Takenori Akiyama, Tomohiro Hikata, Kota Watanabe, Mitsuru Yagi, Nobuyuki Fujita, Eijiro Okada, Narihito Nagoshi, Osahiko Tsuji, Ken Ishii, Kazunari Yoshida, Masaya Nakamura, Morio Matsumoto
Journal: Spinal Cord Ser Cases (2017)

Introduction:
Spinal lipoma and spinal arteriovenous fistula (sAVF) are different pathologies and their co-existence is extremely rare. Here we reported two cases of adult-onset sAVF occurring within a spinal lipoma and with review the literature in an attempt to identify the mechanisim of and optimal treatment of this condition.
Case presentation:
Case 1 was a 51-year-old man who was treated by embolization of the feeding artery and ligation of the draining vein. Case 2 was a 53-year-old man who was treated by embolization and resection of the tumor containing the shunt zone. In both cases, symptoms improved after surgery. However, in Case 1, angiography at 1 month after the surgery revealed recurrence of the arteriovenous shunt.
Discussion:
A literature search revealed only nine other similar case reports. All cases, including ours occurred in adults. In almost all cases, the shunt was located within the spinal lipoma. Pathologic examination revealed venous hypertension, but no evidence of congenital vascular malformation. Given that lipomas release angiogenic factors, the presence of a spinal lipoma may indicate its involvement in the development of acquired sAVF. Our two cases might represent a new subtype of sAVF. Based on our experiences, we recommend resection of the tumor containing the shunt for the management of sAVF.
Preoperative Y-90 microsphere selective internal radiation treatment for tumor downsizing and future liver remnant recruitment: a novel approach to improving the safety of major hepatic resections
Authors: Seza A Gulec, Kenneth Pennington, Michael Hall, Yuman Fong
Journal: World J Surg Oncol (2009)
MeSH terms: Carcinoma, Squamous Cell / radiotherapy, Hepatectomy, Liver Neoplasms / radiotherapy, Yttrium Radioisotopes / therapeutic use, Case Reports, Carcinoma, Squamous Cell / diagnosis, Carcinoma, Squamous Cell / secondary, Embolization, Therapeutic, Female, Fluorodeoxyglucose F18, Humans, Liver Neoplasms / diagnosis, Liver Neoplasms / secondary, Middle Aged, Portal Vein / pathology, Positron-Emission Tomography, Preoperative Care, Tomography, X-Ray Computed, Uterine Cervical Neoplasms / pathology, Yttrium Radioisotopes, Fluorodeoxyglucose F18

Background:
Extended liver resections are being performed more liberally than ever. The extent of resection of liver metastases, however, is restricted by the volume of the future liver remnant (FLR). An intervention that would both accomplish tumor control and induce compensatory hypertrophy, with good patient tolerability, could improve clinical outcomes.
Case presentation:
A 53-year-old woman with a history of cervical cancer presented with a large liver mass. Subsequent biopsy indicated poorly differentiated carcinoma with necrosis suggestive of squamous cell origin. A decision was made to proceed with pre-operative chemotherapy and Y-90 microsphere SIRT with the intent to obtain systemic control over the disease, downsize the hepatic lesion, and improve the FLR. A surgical exploration was performed six months after the first SIRT (three months after the second). There was no extrahepatic disease. The tumor was found to be significantly decreased in size with central and peripheral scarring. The left lobe was satisfactorily hypertrophied. A formal right hepatic lobectomy was performed with macroscopic negative margins.
Conclusion:
Selective internal radiation treatment (SIRT) with yttrium-90 (Y-90) microspheres has emerged as an effective liver-directed therapy with a favorable therapeutic ratio. We present this case report to suggest that the portal vein radiation dose can be substantially increased with the intent of inducing portal/periportal fibrosis. Such a therapeutic manipulation in lobar Y-90 microsphere treatment could accomplish the end points of PVE with avoidance of the concern regarding tumor progression.
Case report of a duplicated cystic duct: A unique challenge for the laparoscopic surgeon
Authors: Semeret Munie, Hassan Nasser, Pauline H Go, Kelly Rosso, Ann Woodward
Journal: Int J Surg Case Rep (2019)
Keywords: bile duct variation, double cystic duct, duplicated cystic duct, laparoscopic cholecystectomy

Introduction:
Anatomical variants of the extrahepatic biliary tree are numerous, adding significantly to the risk of bile duct injury during cholecystectomy, especially when laparoscopic approach is employed. Duplicated cystic ducts draining a single gallbladder are extremely rare.
Presentation of case:
A 34-year-old female presented with signs and symptoms of acute cholecystitis which was confirmed on imaging. She was found to have an accessory cystic duct on laparoscopic cholecystectomy requiring conversion to open laparotomy with intraoperative cholangiogram to delineate the anatomy.
Discussion:
In the English literature, there has been 20 reported cases of double cystic duct with a single gallbladder. Most of these cases were diagnosed intraoperatively despite the completion of a preoperative endoscopic retrograde cholangiopancreatography in a few of these patients.
Conclusion:
The limited success of preoperative biliary tract imaging in demonstrating anatomic aberrancies prior to cholecystectomy clearly highlights the importance of maintaining constant vigilance for even the slightest anatomic abnormality at operation. Any uncertainty or concern for ductal injury mandates immediate operative cholangiogram with cannulation of all structures in question.