OpenMed/multicare-articles huggingface dataset:
Dural Plasmacytoma with Meningeal Myelomatosis in a Patient with Multiple Myeloma
Authors: Nieves Gascón, Héctor Pérez-Montero, Sandra Guardado, Rafael D'Ambrosi, María Ángeles Cabeza, José Fermín Pérez-Regadera
Journal: Case Rep Hematol (2018)
MeSH terms: Case Reports

Here, we describe the case of a 66-year-old male diagnosed with multiple myeloma who presented with generalized tonic-clonic seizures. Magnetic resonance imaging demonstrated a right solid extra-axial parieto-occipital lesion with typical characteristics of meningeal myelomatosis. Biopsy was performed, which diagnosed a dural plasmacytoma. Because of this, we started concomitant therapy with radiotherapy and lenalidomide, but the patient has a poor response to treatment and died few weeks after its initiation. Myelomatous involvement of the dura mater is a rare occurrence, given that only few cases were reported in the English literature. This presentation confers an ominous prognosis and must be a suspect diagnosis in patients diagnosed with multiple myeloma presenting neurological symptoms.
Urinary incontinence as a possible signal of neuromuscular toxicity during immune checkpoint inhibitor treatment: Case report and retrospective pharmacovigilance study
Authors: Yizhang Hu, Wenchao Lu, Borui Tang, Zhixia Zhao, Zhuoling An
Journal: Front Oncol (2022)
Keywords: faers, immune checkpoint inhibitors, immune-related adverse events, neuromuscular adverse events, urinary incontinence

Background:
Immune checkpoint inhibitors (ICIs) are associated with different immune-related adverse events (irAEs), but there is limited evidence regarding the association between urinary incontinence and ICIs.
Methods:
We described the case of a patient experiencing urinary incontinence who later experienced a series of irAEs such as myocarditis, myositis, and neurologic diseases while on ICI treatment in our hospital. In addition, we queried the Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) from the third quarter of 2010 to the third quarter of 2020 to perform a retrospective study to characterize the clinical features of urinary incontinence associated with ICIs.
Result:
In the FAERS study, 59 cases of ICI-related urinary incontinence were retrieved, and approximately 32.2% of the cases were fatal. Combination therapy with nervous system drugs and age >80 years old were the significant risk factors for fatal outcomes. Among these cases of ICI-related urinary incontinence, 40.7% (n = 24) occurred concomitantly with other adverse events, especially, neurological (fifteen cases), cardiovascular (seven cases), musculoskeletal (six cases), and urological disorders (five cases). Five cases had an overlapping syndrome similar to our case report, including one case of myasthenia gravis with myocarditis and another of myasthenic syndrome with polymyositis.
Conclusion:
ICI-related urinary incontinence might be a signal of fatal neuromuscular irAEs, especially when it occurs concomitantly with ICI-associated neuromuscular-cardiovascular syndrome. Clinicians should be aware of the occurrence of urinary incontinence to identify potentially lethal irAEs in the early phase.
Storage Artifact Masquerading as Yeast: Presenting a Diagnostic Pitfall
Authors: Elena M Fenu, Tawfeq Naal, Elizabeth Palavecino
Journal: Case Rep Pathol (2022)
MeSH terms: Case Reports

Abnormal cell morphology can result from prolonged specimen storage, both for red and white blood cells. In particular, nuclear pyknosis of segmented neutrophils can occur in both peripheral blood and body fluids and may represent a diagnostic pitfall as it can mimic intracellular yeast or bacteria morphology. Pathologists are frequently asked to examine body fluid smears which are thought to contain microorganisms, and the presence of an unexpected organism can be especially concerning. Morphologic changes from prolonged storage may be encountered infrequently, and it is important to be aware of them in order to avoid misrepresentation, as additional work-up may be required for a suspected case of an unexpected fungal infection.
Case report: Toceranib as adjuvant chemotherapy in a dog with incompletely resected combined hepatocellular-cholangiocarcinoma
Authors: Sang-Won Kim, Ju-Won Choi, Jeon-Mo Kim, Hun-Young Yoon, Kieun Bae, Kyong-Ah Yoon, Jung-Hyun Kim
Journal: Front Vet Sci (2023)
Keywords: chemotherapy, combined hepatocellular-cholangiocarcinoma, dog, toceranib, tyrosine kinase inhibitor
MeSH terms: Case Reports

An 11-year-old intact female mixed breed dog was presented with abdominal distention and elevated hepatic enzyme levels. Computed tomography revealed a multicystic hepatic mass at the left medial lobe adjacent to the diaphragm and caudal vena cava. The mass was surgically removed with partial hepatectomy, but it could not be removed completely because of adhesion to the diaphragm. The tissue was submitted for histopathologic evaluation, and the patient was diagnosed with stage IIIA combined hepatocellular-cholangiocarcinoma (cHCC-CC). Considering the residual tumor tissue from incomplete surgical excision, adjuvant chemotherapy was recommended. Tumor tissue obtained from the patient was assessed using an anticancer drug response prediction test, and the results showed that toceranib phosphate was the most effective chemotherapeutic agent for this patient. Toceranib was initiated (3.1 mg/kg, PO, q48 h), and routine adverse effect assessment, including systemic blood pressure measurement, complete blood count, serum biochemical evaluations, and urinalysis were performed at two-week intervals for the first 2 months and every 2 months thereafter. Radiography and ultrasonography were conducted at one-month intervals for the first two months and then every 2 months subsequently. Concurrent hyperadrenocorticism was managed with trilostane (1 to 5 mg/kg, PO, q12h). The patient showed no critical adverse effects of chemotherapy, obvious recurrence, or metastasis. The response to toceranib was assessed as a partial response, and the patient is still alive over 23 months after tumor excision. This is the first case report describing chemotherapy for a dog with cHCC-CC.
An adult female patient with single atrium and single ventricle undergoing appendectomy: A case report
Authors: Yu Wu, Zenghua Cai, Jianzheng Cheng, Bo Zhang, Guoji Wang, Wei Li, Zaiwang Zhang
Journal: Front Cardiovasc Med (2023)
Keywords: adult patient, anesthesia, appendicitis, low metabolic equivalent, single atrium and single ventricle
MeSH terms: Case Reports

Appendicitis is one of the common diseases, and appendectomy is one of the most commonly performed procedures. Single atrium and single ventricle are rare heart diseases, and very few patients survive to adulthood. We report a patient with single atrial and single ventricles undergoing appendectomy with transverse abdominis plane block and dexmedetomidine sedation anesthesia with smooth postoperative appendectomy.
Anti-MuSK-Positive Myasthenia Gravis in a Patient with Parkinsonism and Cognitive Impairment
Authors: S Lanfranconi, S Corti, P Baron, G Conti, L Borellini, N Bresolin, A Bersano
Journal: Neurol Res Int (2011)
MeSH terms: Case Reports

Muscle-specific tyrosine kinase- (MuSK-) antibodies-positive Myasthenia Gravis accounts for about one third of Seronegative Myasthenia Gravis and is clinically characterized by early onset of prominent bulbar, neck, shoulder girdle, and respiratory weakness. The response to medical therapy is generally poor. Here we report a case of late-onset MuSK-antibodies-positive Myasthenia Gravis presenting with signs of cognitive impairment and parkinsonism in addition to bulbar involvement and external ophthalmoplegia. The pattern of involvement of both peripheral and central nervous system dysfunction might suggest a common pathogenic mechanism, involving impaired cholinergic transmission.
Prolonged QT Syndrome and Seizure Secondary to Alkaline Earth Metal Deficiency: A Case Report
Authors: A McKinney, B C Keegan
Journal: Case Rep Med (2011)
MeSH terms: Case Reports

Introduction. Alkaline earth metal deficiency is recognized as a cause of both seizure and long QT syndrome. Their deficiency can have significant repercussions on the function of cells, tissues, and organs of the body. An understanding of the role of electrolytes allows an appreciation of the significance of depleted levels on cell function. Case Report. A 65-year-old lady was admitted with symptoms of chest discomfort, vomiting, increased stoma output, and dizziness. Two days following admission she suffered a tonic-clonic seizure. ECG review demonstrated a prolonged QTc interval, raising the possibility of an underlying Torsades de Pointes as the precipitant. This was attributed to electrolyte disturbance arising as a result of multiple aetiologies. Discussion. This paper highlights the multisystem effects of electrolyte disturbance, with emphasis upon its role in precipitating cardiac arrhythmia and neurological symptoms.
Late-Life Presentation of Unsuspected G6PD Deficiency
Authors: Marcos Benchimol, Laura Bernardo Madeira, Ricardo de Oliveira-Souza
Journal: Case Rep Crit Care (2018)
MeSH terms: Case Reports

Deficiency of glucose-6-phosphate dehydrogenase (G6PD) is the commonest enzyme deficiency in humans with a wide range of possible clinical manifestations depending on the specific genetic variant in each case. Here we present the case of an 86-year-old male of African descent who acutely developed symptoms of G6PD deficiency immediately after he received methylene blue for treating methemoglobinemia. The contrast between a low SO2 on pulse oximetry and a normal arterial gas sampling raised the possibility of methemoglobinemia. The patient was treated with packed red blood cells and folic acid, and a rapid clinical improvement followed by normalization of the red blood cell count ensued. In view of the patient's advanced age, the lack of a history of similar episodes in the past, and the normal laboratory results during the hemolytic crisis, this case remained a diagnostic challenge for over three months, when a follow-up measure of G6DP activity eventually confirmed the diagnosis. A latent deficiency of G6PD may become clinically manifest under the appropriate triggering conditions even in elderly patients and in the absence of past or current clinical and laboratory evidence of G6PD deficiency.
Case Report: Diagnosis of Myelodysplastic Syndrome in a 72-Year-Old Female With Interstitial Lung Disease
Authors: Nikoleta Bizymi, Georgios Pitsidianakis, Despo Ierodiakonou, Georgios Stathakis, Eirini Vasarmidi, Stavroti Hiraki, Maria Bolaki, Konstantinos Karagiannis, Michail Fanaridis, Konstantinos Liopyrakis, Leonidas Marinos, Irini Xilouri, Katerina M Antoniou, Nikolaos Tzanakis
Journal: Front Med (Lausanne) (2021)
Keywords: corticosteroid-therapy, immune deregulation, mycophenolate mofetil, myelodysplastic syndrome, pulmonary infiltrates
MeSH terms: Case Reports

Acute fibrinous and organizing pneumonia (AFOP) is an entity that can be secondary to various conditions leading to lung injury, such as infections, malignancies, and various autoimmune conditions or idiopathic interstitial lung disease, when no obvious underlying cause is identified. Myelodysplastic syndromes (MDS), on the other hand, are a spectrum of clonal myeloid disorders, with a higher risk of acute leukemia, characterized by ineffective bone marrow (BM) hematopoiesis and, thus, peripheral blood (PB) cytopenias. Immune deregulation is thought to take part in the pathophysiology of the disease, including abnormal T and/or B cell responses, innate immunity, and cytokine expression. In the literature, there are a few case reports of patients with MDS that have presented pulmonary infiltrates and were diagnosed as having AFOP or organizing pneumonia (OP). It is rare, though, to have isolated pulmonary infiltrates without Sweet's syndrome or even the pulmonary infiltrates to precede the diagnosis and treatment of MDS, which was our case. We present a 72-year-old female developing new lung infiltrates refractory to antibiotic treatment that responded well to corticosteroids and was histologically described as having OP. The treatment was gradually successfully switched to mycophenolate mofetil (MMF). The patient was later diagnosed with MDS. This interesting case report suggests firstly that a diagnosis of AFOP or OP should alert the clinician to search for an underlying cause including MDS and vice versa, the use of systemic steroids should not be postponed, and, finally, that MMF can successfully be used in these patients.
Novel mutation in exon11 of PRKCG (SCA14): A case report
Authors: Rong Sun, Xiang Tang, Xueqin Cao, Xinyu Shao, Hong Sun
Journal: Front Genet (2023)
Keywords: prkcg gene mutation, case report, dystaxia, exon11, spinocerebellar ataxia type 14
MeSH terms: Case Reports

Introduction: PRKCG mutations have been implicated in the pathogenesis of spinocerebellar ataxia type 14 (SCA14), which is a rare autosomal dominant disease marked by cerebellar degeneration, dysarthria, and nystagmus. Until now, there has never been a report of patients with mutations of c.1232G>C worldwide. Case description: We report a case of a 30-year-old Chinese man with episodic dystaxia, speech disorder, and cognitive impairment; however, his father exclusively exhibited a speech disorder regardless of the same mutation. Whole-exome sequencing revealed a heterozygous c.1232G>C (p.G411A) variant of PRKCG. Conclusion: This case presents an extended genotype and phenotype of SCA14, and emphasizes the importance of gene sequencing in patients with spinocerebellar ataxia.
Salt losing obstructive uropathy with paradoxically low urinary sodium concentration: salt entrapment in an obstructed ectopic ureterocele
Authors: Steven M Zangan, David K Yousefzadeh
Journal: ISRN Pediatr (2011)
MeSH terms: Case Reports

A 6-month-old hyponatremic female with failure to thrive had low urinary sodium concentration. Renal sonography revealed a duplex left collecting system with obstruction of the upper moiety as a blind-ended ectopic ureterocele extending to the bladder base. The echogenicity of the urine within the upper pole system was greater than the bladder contents. We believed that low urinary sodium concentration represented a false negative test and the salt loss by the obstructed left kidney was entrapped in the upper pole collecting system. Prior to ureterocele repair, intraoperative bladder and ureterocele aspirates revealed discordant sodium concentration supporting the sonographic conclusion.
Retinal Artery Occlusion Secondary to Buerger's Disease (Thromboangiitis Obliterans)
Authors: Erdem Eris, Mehmet Emin Sucu, Irfan Perente, Zeynep Alkın, Abdullah Ozkaya, Hatice Nur Tarakcioglu
Journal: Case Rep Ophthalmol Med (2017)
MeSH terms: Case Reports

Purpose. To report a case report of one patient suffering from retinal artery occlusion secondary to Buerger's disease, in order to raise awareness to this etiology in the differential diagnosis of retinal artery occlusion. Methods. A retrospective case report of a patient with retinal artery occlusion secondary to Buerger's disease. Data retrieved from the medical records included exposure, complaints, visual acuity, clinical findings and imaging, laboratory assessment, treatment, disease course, and visual outcome. Results. Diagnosis of retinal artery occlusion secondary to Buerger's disease was established based on ruling out other causes of retinal artery occlusion. Inflammatory retinal vascular disease, permanent vision loss, and macular atrophy were shown in this case. Conclusion. The very first case of central retinal artery occlusion (CRAO) in a 64-year-old male patient with Buerger's disease. Although diagnosing CRAO based on both fundoscopic and fluorescein angiographic findings is not difficult, revealing underlying condition of CRAO occasionally could be challenging.
Cognitive Therapy for Social Anxiety Disorder in Adolescents: A Development Case Series
Authors: Eleanor Leigh, David M Clark
Journal: Behav Cogn Psychother (2016)
Keywords: cognitive therapy, adolescent, social anxiety, young people
MeSH terms: Anxiety Disorders / therapy, Cognitive Behavioral Therapy / methods, Case Reports, Research Support, Non-U.S. Gov't, Adolescent, Case-Control Studies, Child, Depressive Disorder / therapy, Female, Humans, Male, Phobic Disorders / therapy, Pilot Projects, Social Behavior, Social Behavior Disorders / therapy, Surveys and Questionnaires

Background:
Social anxiety disorder is common and typically starts in childhood or adolescence. Cognitive Therapy for Social Anxiety Disorder (CT-SAD) in adults is a well-established treatment that shows strong evidence of differential effectiveness when compared to other active treatments. In contrast, CBT approaches to social anxiety in young people have yet to demonstrate differential effectiveness and there is some evidence that young people with social anxiety disorder respond less well than those with other anxiety disorders.
Aims:
To adapt CT-SAD for use with adolescents and conduct a pilot case series.
Method:
Five adolescents, aged 11-17 years, with a primary DSM-5 diagnosis of social anxiety disorder received a course of CT-SAD adapted for adolescents. Standardized clinical interview and questionnaire assessments were conducted at pre and posttreatment, and 2 to 3-month follow-up.
Results:
All five participants reported severe social anxiety at baseline and achieved remission by the end of treatment. Significant improvements were also observed in general anxiety, depression, concentration in the classroom, and putative process measures (social anxiety related thoughts, beliefs and safety behaviours).
Conclusions:
An adapted form of CT-SAD shows promise as a treatment for adolescents.
Resection of a solitary bone metastasis using preoperative computed tomography (CT)-guided hook wire localization: a case report
Authors: Benjamin Augereau, Nicolas Pointet, Pier-Olivier Duboe, Tanguy Vendeuvre
Journal: Pan Afr Med J (2022)
Keywords: bone metastasis, case report, computed tomography, hook-wire
MeSH terms: Bone Neoplasms / diagnostic imaging, Bone Neoplasms / surgery, Lung Neoplasms / diagnostic imaging, Lung Neoplasms / pathology, Lung Neoplasms / surgery, Solitary Pulmonary Nodule / pathology, Solitary Pulmonary Nodule / surgery, Case Reports, Female, Humans, Margins of Excision, Thoracic Surgery, Video-Assisted / methods, Tomography, X-Ray Computed / methods

Secondary bone metastasis are a common evolution of many types of cancer. In some instance, it is needed to remove those metastases to improve the prognosis of the patient. Bone metastasis that are invisible and non-palpable during the intervention are difficult to remove while being sure to respect safe resection margins. We present the case of a woman suffering from breast cancer. Despite the treatment of the primitive lesion, she presented a solitary bone metastasis on her iliac crest. The lesion was removed surgically but could not be seen or touched during the procedure due to its location. To be certain to remove this lesion during surgery, while respecting safe resection margins, we performed a pre-operative computed tomography (CT)-guided hook wire localization. Using this method, the anatomopathological examination confirmed the tumoral nature of the lesion and that the resection margins were in a safe zone. This technique frequently used to target soft lesion in cases of breast or lung cancers could therefore be used the same way with solid bone lesion.
Hepatic artery mycotic aneurysm associated with staphylococcal endocarditis with successful treatment: case report with review of the literature
Authors: Dhara Chaudhari, Atif Saleem, Pranav Patel, Sara Khan, Mark Young, Gene LeSage
Journal: Case Reports Hepatol (2013)

Mycotic hepatic artery aneurysm is a vascular pathology associated with bacterial endocarditis. It is rare in occurrence after the introduction of effective antibiotics. We present a young patient with injection drug abuse associated staphylococcal endocarditis which was successfully treated with antibiotics and valve replacement who presented with abdominal pain. He was found to have mycotic aneurysm of hepatic artery which was successfully treated with coil embolization.
Hepatic primary neuroendocrine carcinoma: about a new case
Authors: Hasna Derouich, Fouad Haddad, Mohamed Moukhlissi, Wafaa Hliwa, Ahmed Bellabah, Wafaa Badre
Journal: Pan Afr Med J (2015)
Keywords: carcinoma, liver, neuroendocrine
MeSH terms: Abdominal Pain / etiology, Antineoplastic Combined Chemotherapy Protocols / therapeutic use, Carcinoma, Neuroendocrine / pathology, Liver Neoplasms / pathology, Case Reports, Biopsy, Carcinoma, Neuroendocrine / diagnosis, Carcinoma, Neuroendocrine / drug therapy, Follow-Up Studies, Humans, Liver Neoplasms / diagnosis, Liver Neoplasms / drug therapy, Male, Middle Aged, Remission Induction

We report a new case of Primary hepatic neuroendocrine carcinoma admitted in our hospital and revealed in 53 years man by epigastric pain and flush syndrome. A liver biopsy with immunohistochemical study confirmed the original location of a neuroendocrine carcinoma. After 12 cures of Chemotherapy and a follow up of 12 months, the patient is still in complete remission.
Acute Disseminated Encephalomyelitis following Vaccination against Hepatitis B in a Child: A Case Report and Literature Review
Authors: Jun-Liang Yuan, Shuang-Kun Wang, Xiao-Juan Guo, Wen-Li Hu
Journal: Case Rep Neurol Med (2016)

Acute disseminated encephalomyelitis (ADEM) is an inflammatory demyelinating disease of the central nervous system, which has been associated with several vaccines such as rabies, diphtheria-tetanus-polio, smallpox, measles, mumps, rubella, Japanese B encephalitis, pertussis, influenza, and the Hog vaccine. Here, we presented a case of 12-year-old child who suffered from ADEM three weeks after hepatitis B vaccination. He was admitted to our hospital with symptoms of weakness of limbs, high fever, and alteration of consciousness. Some abnormalities were also found in CSF. Treatment with high-dose corticosteroids and intravenous immunoglobulin had significant effect, with marked improvement of the clinical symptoms and the results of CSF. The findings of MRI also detected some abnormal lesions located in both brain and spinal cord. The clinical features, the findings of CSF and MRI, and therapeutic effect may contribute to such diagnosis of ADEM.
Brain Parenchyma (pons) Involvement by Visceral Leishmaniasis: A Case Report
Authors: Moslem Sedaghattalab, Arsalan Azizi
Journal: Iran J Parasitol (2018)
Keywords: brain, leishmaniasis, pons, visceral
MeSH terms: Case Reports

Leishmaniasis, as a vector-borne disease, is transmitted by sandfly and caused by Leishmania protozoa. Brain involvement rarely occurs in visceral leishmaniasis. In this paper, a rare case of pons involvement by visceral leishmaniasis (VL) is reported. A 54 yr old man from Southwest of Iran (Yasuj) presented to the Emergency Ward with a 3-wk history of headache (continuous, throbbing, and general), fever, chills, weakness, anorexia, and weight loss.
Splenic Infarction in Acute Cytomegalovirus and Human Parvovirus Concomitant Infection
Authors: Tomoya Harada, Yuriko Sueda, Kensaku Okada, Tsuyoshi Kitaura, Kosuke Yamaguchi, Haruhiko Makino, Masaki Nakamoto, Hiroki Chikumi, Akira Yamasaki
Journal: Case Rep Infect Dis (2018)
MeSH terms: Case Reports

We present a case report of a 35-year-old woman who had splenic infarction. She had persistent high fever, systemic joint pain, and abnormal liver function. She was diagnosed with cytomegalovirus and human parvovirus B19 concomitant infection. Her coagulopathy test revealed no abnormal results. She was treated with intravenous ganciclovir for 13 days; consequently, her splenic infarction improved after 7 weeks. As per our knowledge, this is the first case of cytomegalovirus and parvovirus B19 coinfection complicated by splenic infarction. Cytomegalovirus and parvovirus B19 may induce a hypercoagulation state during the acute phase.