OpenMed/multicare-articles huggingface dataset:
Implantation of an Intraosseous Transcutaneous Amputation Prosthesis Restoring Ambulation After Amputation of the Distal Aspect of the Left Tibia in an Arabian Tahr ( Arabitragus jayakari)
Authors: Andrzej Golachowski, Masoud Rashid Al Ghabri, Barbara Golachowska, Hamood Al Abri, Marek Lubak, Michal Sujeta
Journal: Front Vet Sci (2019)
Keywords: arabian tahr, arabitragus jayakari, itap, intraosseous transcutaneous amputation prosthesis, amputation, prosthesis, rehabilitation, wildlife
MeSH terms: Case Reports

Objective: This document is to report the clinical application and outcome of custom designed Intraosseous Transcutaneous Amputation Prosthesis (ITAP) in the left hind limb in a wildlife Arabian Tahr (Arabitragus jayakari). Sample Population: A 4-year-old, 15 kg Arabian female Tahr from the Omani Mammals Breeding Center. Method: The distal aspect of the left tibia was amputated due to trauma. A custom designed ITAP was inserted into the tibia 5 months after amputation. Two weeks after the surgery an exoprosthesis was attached to the limb. The outcome of the surgery was measured by means of assessments of the limb function and radiographic examination. Results: Fourteen days after surgery the exoprosthesis was attached. The animal was walking showing lameness grade 2/5 (AAEP lameness scale). Within three weeks lameness improved to grade 1/5. Skin integration with the ITAP was achieved within 28 days. The Tahr was successfully reunited with the breeding herd. Conclusion: Application of the ITAP to the left tibia of the Arabian Tahr resulted in positive functional outcomes. Six months post-surgery observations confirmed ambulation with grade 1/5 lameness was restored. The animal was reintroduced to the breeding group. Clinical Relevance: ITAP offers a viable option to restore functionality and ambulation in wildlife.
A Rare Case of Rivaroxaban Causing Delayed Symptomatic Hepatocellular Injury and Hyperbilirubinemia
Authors: Keith Glenn, Patrick Chen, Mustafa Musleh, Rao Pallivi, Melissa Grilliot
Journal: Case Rep Gastrointest Med (2017)
MeSH terms: Case Reports

Importance. As Rivaroxaban has increased in popularity, it has been accompanied with a growing body of evidence displaying its ability to cause drug induced liver injury (DILI). Observation. A 74-year-old Caucasian female developed Rivaroxaban DILI two weeks after finishing a 14-day course. The patient was symptomatic and jaundiced with elevated transaminases and hyperbilirubinemia with normal lab values two months priorly. Liver biopsies showed mixed inflammatory infiltrate of lymphocytes, neutrophils and eosinophils, rare necrotic hepatocytes, and canalicular and intrahepatocellular cholestasis, all of which are consistent with DILI. Conclusion and Relevance. We present this case to add to the growing evidence that Rivaroxaban can be associated with severe, symptomatic liver injury and to ensure physicians are aware of these possible side effects of novel anticoagulants with their increasing use.
Aggregatibacter actinomycetemcomitans pneumonia mimicking lung cancer in a previously healthy 12-year-old child from Saudi Arabia: a case report
Authors: Abdullah Al-Nafeesah
Journal: Pan Afr Med J (2020)
Keywords: aggregatibacter actinomycetemcomitans, saudi arabia, children, pneumonia
MeSH terms: Aggregatibacter actinomycetemcomitans / isolation & purification, Lung Neoplasms / diagnosis, Pasteurellaceae Infections / diagnosis, Pneumonia, Bacterial / diagnosis, Case Reports, Anti-Bacterial Agents / administration & dosage, Child, Follow-Up Studies, Humans, Male, Pasteurellaceae Infections / drug therapy, Pneumonia, Bacterial / drug therapy, Saudi Arabia, Treatment Outcome, Anti-Bacterial Agents

Aggregatibacter actinomycetemcomitans formely known as Actinobacillus actinomycetemcomitans is a known part of the normal oral flora. It can sometimes cause oral or rarely extra-oral infections secondary to hematogenous extension or aspiration. It is a rare cause of invasive pneumonia. It can resemble tuberculosis or lung cancer in its presentation. Making the diagnosis in such case is crucial for better management that usually require tissue biopsy. We report a case of Aggregatibacter actinomycetemcomitans invasive pneumonia in a 12-year-old previously healthy boy from Saudi Arabia. After a prolonged course of antibiotics, clinical and radiological follow up showed complete resolution of the infection.
Bone Metastases of Glioblastoma: A Case Report and Review of the Literature
Authors: Wei Zhang, Yuan-Yuan Cai, Xiao-Li Wang, Xiao-Xiao Wang, Yang Li, Gui-Yan Han, Yu-Jing Chu, Yun-Xiang Zhang, Fu-Rong Hao
Journal: Front Oncol (2021)
Keywords: case report, extracranial metastasis, glioblastoma, intercostal nerve, nerve root, soft tissue metastasis
MeSH terms: Case Reports

Background:
Glioblastoma (GBM) is the most common primary intracranial tumor and originates from the small pool of adult neural stem and progenitor cells (NSPCs). According to the World Health Organization (WHO) classification of brain tumors, gliomas are classified into grades I-IV, and GBM is defined as the highest grade (IV). GBM can be disseminated by cerebrospinal fluid (CSF), but extracranial metastasis is rare. Additionally, the pathway and mechanism involved remain unclear.
Case presentation:
We report a rare case of left temporal lobe GBM with multiple bone metastases and soft tissue metastasis. This 49-year-old right-handed man who was diagnosed with GBM underwent surgery on May 9, 2017, followed by radiochemotherapy in June 2017. On August 13, 2019, local relapse was found. Then, the patient received a second surgery but not radiochemotherapy. In November 2019, the patient was reported to be suffering from low back pain for nearly 1 month. On December 6, 2019, magnetic resonance imaging (MRI) of the thoracolumbar vertebrae and abdominal computed tomography (CT) confirmed metastases on the ninth posterior rib on the right, the third anterior rib on the left, and the T7 and T10 vertebrae and their appendages. CT-guided rib space-occupying puncture biopsy was performed, and GBM was identified by pathology.
Conclusion:
We should pay attention to extracranial metastasis of GBM. Timely detection and early treatment improve overall quality of patients' life. The extracranial metastasis in this patient may have occurred through the spinal nerve root or intercostal nerve. Further clinical observations are required to clarify the pathway and mechanism involved.
Two Children With Steroid-Resistant Significant Proteinuria Due to Nonsense Mutations of the TRIM8 Gene: A Case Report and Literature Review
Authors: Xiaojie Li, Yaqin Wei, Meiqiu Wang, Lili Jia, Zhuo Shi, Xiao Yang, Tao Ju, Qianhuining Kuang, Zhengkun Xia, Chunlin Gao
Journal: Front Pediatr (2022)
Keywords: fsgs, trim8 gene, children, epileptic encephalopathy, steroid-resistant significant proteinuria
MeSH terms: Case Reports

Background:

TRIM8 gene mutations have been reported as the genetic basis of autosomal dominant (AD) neuro-renal syndrome in children, which presents with epileptic encephalopathy, focal segmental glomerulosclerosis (FSGS), developmental delay, and mental retardation. In this study, we report the cases of two children with significant proteinuria due to de novo nonsense mutations of the TRIM8 gene.
Case presentation:
Case 1 was a 7-year-old girl who presented with proteinuria and developmental delay, and her renal biopsy showed FSGS. She developed end-stage renal disease (ESRD) 3 years after onset. Case 2 was another 7-year-old girl who developed proteinuria only at age 3, and renal biopsy showed glomerular segmental mesangial proliferative lesions. The two girls underwent genetic testing but we did not find a positive result in the whole exon. However, cluster analysis revealed two new nonsense mutations of the TRIM8 gene (c.1461C>A, p.Tyr 487* and c.1453C>T, p.Gln485*).
Conclusions:
We reported the clinical manifestation of this neuro-renal syndrome for the first time in China. It is necessary to perform genetic testing in children with steroid-resistant significant proteinuria to identify its etiology and avoid the side effects of immunosuppressants.
A case report: high dose melphalan as a conditioning regimen for multiple myeloma induces sinus arrest
Authors: Liang-Liang Ma, Ying Liu, Si-Xun Jia, Hai-Chen Lv, Mei-Yun Fang, Yun-Long Xia
Journal: Cardiooncology (2020)
Keywords: arrhythmia, autologous stem cell transplantation, melphalan, multiple myeloma, sinus arrest

High dose melphalan is commonly used as a conditioning regimen for autologous stem cell transplantation in multiple myeloma. There are reports of adverse cardiac events with melphalan manifested by supraventricular tachycardia and atrial fibrillation. Here, we report a rare case of a 58 year old female with multiple myeloma, who developed sinus arrest after autologous stem cell transplantation using high dose melphalan as a conditioning regimen. It was severe and rare, therefore, monitoring for cardiac toxicity in patients receiving high-dose melphalan is mandatory.
Pneumoperitoneum without Intestinal Perforation in a Neonate: Case Report and Literature Review
Authors: Prabhavathi Gummalla, Gratias Mundakel, Maksim Agaronov, Haesoon Lee
Journal: Case Rep Pediatr (2017)
MeSH terms: Case Reports

Pneumoperitoneum in a preterm neonate usually indicates perforation of the intestine and is considered a surgical emergency. However, there are cases of pneumoperitoneum with no evidence of rupture of the intestine reported in the literature. We report a case of pneumoperitoneum with no intestinal perforation in a preterm neonate with respiratory distress syndrome who was on high frequency oscillatory ventilation (HFOV). He developed bilateral pulmonary interstitial emphysema with localized cystic lesion, likely localized pulmonary interstitial emphysema, and recurrent pneumothoraces. He was treated with dexamethasone to wean from the ventilator. Pneumoperitoneum developed in association with left sided pneumothorax following mechanical ventilation and cardiopulmonary resuscitation. Pneumoperitoneum resolved after the pneumothorax was resolved with chest tube drainage. He died from acute cardiorespiratory failure. At autopsy, there was no evidence of intestinal perforation. This case highlights the fact that pneumoperitoneum can develop secondary to pneumothorax and does not always indicate intestinal perforation or require exploratory laparotomy.
A Challenging Case of Hepatoblastoma Concomitant with Autosomal Recessive Polycystic Kidney Disease and Caroli Syndrome-Review of the Literature
Authors: Nevil Kadakia, Steven J Lobritto, Nadia Ovchinsky, Helen E Remotti, Darrell J Yamashiro, Jean C Emond, Mercedes Martinez
Journal: Front Pediatr (2017)
Keywords: caroli syndrome, autosomal recessive polycystic kidney disease, congenital hepatic fibrosis, hepatoblastoma, hepatorenal fibrocystic diseases
MeSH terms: Case Reports

We report a rare case of an 18-month-old female with autosomal recessive polycystic kidney disease, Caroli syndrome, and pure fetal type hepatoblastoma. The liver tumor was surgically resected with no chemotherapy given. Now 9 years post resection she demonstrates no local or distant recurrence and stable renal function.
Musicogenic seizures in temporal lobe epilepsy: Case reports based on ictal source localization analysis
Authors: Ionut-Flavius Bratu, Adriana Elena Nica, Irina Oane, Andrei Daneasa, Sergiu Stoica, Andrei Barborica, Ioana Mindruta
Journal: Front Neurol (2023)
Keywords: anti-gad, focal cortical dysplasia, ictal source localization, independent component analysis, musicogenic epilepsy, temporal lobe
MeSH terms: Case Reports

Musicogenic epilepsy is a rare form of reflex epilepsy in which seizures are provoked by music. Different musicogenic stimuli have been identified: pleasant/unpleasant music or specific musical patterns. Several etiologies have been uncovered, such as focal cortical dysplasia, autoimmune encephalitis, tumors, or unspecific gliosis. In this article, we report two patients with musicogenic seizures. The first patient was diagnosed with structural temporal lobe epilepsy. Her seizures were elicited by music that she liked. Interictal and ictal video-electroencephalography (video-EEG) and signal analysis using independent component analysis revealed the right temporal lobe seizure onset extending over the neocortical regions. The patient underwent right temporal lobectomy (including the amygdala, the head, and the body of the hippocampus) and faced an Engel IA outcome 3 years post-surgery. The second patient was diagnosed with autoimmune temporal lobe epilepsy (GAD-65 antibodies). Her seizures were triggered by contemporary hit radio songs without any personal emotional significance. Interictal and ictal video-electroencephalography (video-EEG) and independent component analysis highlighted the left temporal lobe seizure onset extending over the neocortical regions. Intravenous immunoglobulin therapy was initiated, and the patient became seizure-free at 1 year. In conclusion, musicogenic seizures may be elicited by various auditory stimuli, the presence or absence of an emotional component offering an additional clue for the underlying network pathophysiology. Furthermore, in such cases, the use of independent component analysis of the scalp EEG signals proves useful in revealing the location of the seizure generator, and our findings point toward the temporal lobe, both mesial and neocortical regions.
Successful treatment of tracheal stenosis by rigid bronchoscopy and topical mitomycin C: a case report
Authors: Jyi Lin Wong, Siew Teck Tie, Bohari Samril, Chee Lun Lum, Mohammad Rizal Abdul Rahman, Jamalul Azizi Abdul Rahman
Journal: Cases J (2010)

Tracheal stenosis is a known complication of prolonged intubation. It is difficult to treat and traditional surgical approach is associated with significant risk and complications. Recurrent stenosis due to granulation tissue necessitates repeated procedures. We describe a case of short web-like tracheal stenosis (concentric membranous stenosis less than 1 cm in length without associated cartilage damage) managed by a minimally invasive thoracic endoscopic approach. Topical application of Mitomycin C, a potent fibroblast inhibitor reduces granulation tissue formation and prevents recurrence.
Concordant nephrotic syndrome in twins with PAX2 and MYO1E mutations
Authors: Oulimata K Grossman, Claire F Schretlen, Linda S Nield
Journal: Clin Nephrol Case Stud (2022)
Keywords: pax2-myo1e, focal segmental glomerulosclerosis, nephrotic syndrome, paired box gene 2
MeSH terms: Case Reports

Introduction:
The medical literature is scant with reports of twins diagnosed with nephrotic syndrome associated with genetic mutations. Mutations in the protein coding paired box gene 2 (PAX2) and in the non-muscle class I myosin, myosin 1E, (MYO1E) have been implicated in the development of steroid-resistant nephrotic syndrome. We describe the first case, to our knowledge, of the concordant presentation of nephrotic syndrome in twins with simultaneous mutations in PAX2 and MYO1E.
Case report:
At 32 months and 33 months of age, monochorionic, diamniotic twin girls presented with nephrotic syndrome. Each twin experienced three relapses during or after completion of corticosteroid treatment. Sustained remission was achieved with tacrolimus. Genetic testing of each twin revealed two heterozygous mutations of MYO1E and one homozygous mutation of PAX2. Renal biopsy results of one twin revealed pathologic findings consistent with minimal change nephropathy. The twins' phenotypes have been essentially identical.
Conclusion:
Our cases add to the scant medical literature addressing nephrotic syndrome in twins with genetic mutations. Close monitoring of our unique patients will provide novel information about the clinical significance of combined mutations in PAX2 and MYO1E.
Congenital Membranous Stapes Footplate Producing Episodic Pressure-Induced Perilymphatic Fistula Symptoms
Authors: Han Matsuda, Yasuhiko Tanzawa, Tatsuro Sekine, Tomohiro Matsumura, Shiho Saito, Susumu Shindo, Shin-Ichi Usami, Yasuhiro Kase, Akinori Itoh, Tetsuo Ikezono
Journal: Front Neurol (2020)
Keywords: ctp, plf, cochlin-tomoprotein, perilymph fistula, pneumolabyrinth, stapes, superior canal dehiscence, third window syndrome
MeSH terms: Case Reports

Introduction: Recent third window syndrome studies have revealed that the intact bony labyrinth and differences in the stiffness of the oval and round windows are essential for proper cochlear and vestibular function. Herein we report a patient with a congenital dehiscence of the right stapes footplate. This dehiscence caused long-standing episodic pressure-induced vertigo (Hennebert sign). At the time of presentation, her increased thoracic pressure changes induced the rupture of the membranous stapes footplate. Perilymph leakage was confirmed by imaging and a biochemical test [perilymph-specific protein Cochlin-tomoprotein (CTP) detection test]. Case Report: A 32-year-old woman presented with a sudden onset of right-sided hearing loss and severe true rotational vertigo, which occurred immediately after nose-blowing. CT scan showed a vestibule pneumolabyrinth. Perilymphatic fistula (PLF) repair surgery was performed. During the operation, a bony defect of 0.5 mm at the center of the right stapes footplate, which was covered by a membranous tissue, and a tear was found in this anomalous membrane. A perilymph-specific protein CTP detection test was positive. The fistula in the footplate was sealed. Postoperatively, the vestibular symptoms resolved, and her hearing improved. A more detailed history revealed that, for 15 years, she experienced true rotational vertigo when she would blow her nose. After she stopped blowing her nose, she would again feel normal. Discussion: There is a spectrum of anomalies that can occur in the middle ear, including the ossicles. The present case had a dehiscence of the stapes, with a small membranous layer of tissue covering a bony defect in the center of the footplate. Before her acute presentation to the hospital, this abnormal footplate with dehiscence induced pathological pressure-evoked fluid-mechanical waves in the inner ear, which resulted in Hennebert sign. When patients have susceptibility (e.g., weak structure) to rupture, such as that identified in this case, PLF can be caused by seemingly insignificant events such as nose-blowing, coughing, or straining. Conclusion: This case demonstrates that PLF is a real clinical entity. Appropriate recognition and treatment of PLF can improve a patient's condition and, hence, the quality of life.
Orthodontic Replacement of Lost Permanent Molar with Neighbor Molar: A Six-Year Follow-Up
Authors: Taisa Boamorte Raveli, Ricardo Lima Shintcovsk, Luegya Amorim Henriques Knop, Luana Paz Sampaio, Dirceu Barnabé Raveli
Journal: Case Rep Dent (2017)
MeSH terms: Case Reports

Extraction is very frequent indication in orthodontic planning, especially when there are crowding, biprotrusion, and aesthetically unpleasant profiles. Next to extraction comes space closure, which represents a challenge for orthodontists because of extended treatment time, discomfort created for the patient, tissue tolerance, and stability concerns. When it comes to what mechanics to choose for space closure, loops present two major advantages in relation to sliding mechanics: absence of abrasion and possibility to reach pure dental translation. A case is presented where an adult female patient with early loss of the first lower permanent molars, minor lower crowding, and tooth biprotrusion was treated with upper first bicuspids extraction along with upper and lower space closure done with T-loops to promote best space closure control in order to correct the malocclusion and enhance facial aesthetics.
Nonimmunoglobulin Crystal-Storing Histiocytosis (CSH): Case Report and Literature Review
Authors: Manuel Beltran, Sharad Khurana, Yennifer Gil, Jason T Lewis, Rohit Kumar, James M Foran
Journal: Case Rep Hematol (2020)
MeSH terms: Case Reports

Crystal-storing histiocytosis (CSH) is an uncommon condition in which histiocytes accumulate a crystalline matter within their cytoplasm. Generally, those crystals are composed of either monoclonal or polyclonal immunoglobulin chains, which have a strong association with an underlying lymphoproliferative or plasma cell disorder (LP-PCD). Rarely, CSH has been reported as local or generalized manifestation of a variety of benign disorders. These cases are associated with crystals composed of nonimmunoglobulin substances. We are reporting an exceptional case of a local colonic CSH with Charcot-Leyden crystals. This patient underwent a screening colonoscopy that detected some polyps. The biopsy reported tubular adenomas, with a markedly dense, transmural inflammatory infiltrates, which were predominantly composed of eosinophils and crystal-storing histiocytes containing Charcot-Leyden crystals. The patient had a negative workup for LP-PCD and autoimmune conditions, including a normal skeletal survey and bone marrow aspirate/biopsy. The only positive laboratory workup was an elevated absolute eosinophil count and a positive IgG anti-Strongyloides antibody. Giving those findings, this parasitic infection is the most likely etiology of the CSH in our patient. Although there was an initial negative evaluation for LP-PCD, close monitoring of patients with either immunoglobulin or nonimmunoglobulin CSH is recommended.
Uncommon metastases of invasive lobular breast cancer to the endometrium: a report of two cases and review of the literature
Authors: Raja Briki, Ons Cherif, Badra Bannour, Samir Hidar, Sassi Boughizane, Hedi Khairi
Journal: Pan Afr Med J (2018)
Keywords: invasive lobular breast carcinoma, endometrium, metastases
MeSH terms: Breast Neoplasms / pathology, Carcinoma, Lobular / pathology, Endometrial Neoplasms / diagnosis, Case Reports, Review, Aged, Endometrial Neoplasms / secondary, Female, Follow-Up Studies, Humans, Middle Aged, Uterine Hemorrhage / etiology

Although it is known that breast cancer can metastasize to many organ sites, metastasis to the uterus is uncommon and usually occurs during widespread metastatic disease. Lobular carcinoma is not the most common histological subtypes of breast carcinoma, but it is the most frequent histologic type that causes gastrointestinal, gynecological and peritoneal metastases. The main symptoms of the uterine metastasis depend on the anatomic involvement site. Abnormal uterine bleeding is by far the most important symptom.We highlight the importance of the follow up of patient with breast cancer. A rapid endometrial sampling for confirmation of the diagnosis, should be performed when the routine gynecological follow-up revealed any abnormality. We report two original observations of endometrium metastases of invasive lobular carcinoma of the breast which we detected during follow-up.
Combination treatment of periungual warts
Authors: Sukhdeo Patidar
Journal: J Cutan Aesthet Surg (2008)
Keywords: verruca, electrodessication, trichloroacetic acid
MeSH terms: Case Reports

Periungual wart presents challenge for management in view of their frequent recurrence. The case report demonstrates the efficacy of a combination treatment of electrodessication and trichloroacetic acid application.