OpenMed/multicare-articles huggingface dataset:
Temozolomide-Induced Shrinkage of Invasive Pituitary Adenoma in Patient with Nelson's Syndrome: A Case Report and Review of the Literature
Authors: Maria Kurowska, Andrzej Nowakowski, Grzegorz Zieliński, Joanna Malicka, Jerzy S Tarach, Maria Maksymowicz, Piotr Denew
Journal: Case Rep Endocrinol (2015)

Introduction. Invasive tumours in Nelson's syndrome need aggressive therapy. Recent reports have documented the efficacy of temozolomide (TMZ) in the treatment of adenomas resistant to conventional management. Objective. The review of the literature concerning TMZ treatment of atypical corticotroph adenomas and a case study of 56-year-old woman who developed Nelson's syndrome. Treatment Proceeding. The patient with Cushing's disease underwent transsphenoidal adenomectomy followed by a 27-month-long period of remission. Due to a regrowth of the tumor, she underwent two reoperations followed by stereotactic radiotherapy. Because of treatment failures, bilateral adrenalectomy was performed. Then she developed Nelson's syndrome. A fourth transsphenoidal adenomectomy was performed, but there was a rapid recurrence. Five months later, she underwent a right frontotemporal craniotomy. Due to a rapid regrowth of the tumour, the patient did not receive gamma-knife therapy and was treated with cabergoline and somatostatin analogue for some time. Only TMZ therapy resulted in marked clinical, biochemical, and radiological improvement. To date, this is the first case of invasive corticotroph adenoma in Nelson's syndrome treated with temozolomide in Poland. Conclusion. In our opinion, temozolomide can be an effective treatment option of invasive adenomas in Nelson's syndrome.
Case Series of COVID-19 Asymptomatic Newborns With Possible Intrapartum Transmission of SARS-CoV-2
Authors: Jean-Michel Hascoët, Jean-Marc Jellimann, Cedric Hartard, Apolline Wittwer, Hélène Jeulin, Patricia Franck, Olivier Morel
Journal: Front Pediatr (2020)
Keywords: covid-19, antibodies, case report, newborn, pregnancy, vertical transmission
MeSH terms: Case Reports

Background: Despite the pandemic, data are limited regarding COVID-19 infection in pregnant women and newborns. This report aimed to bring new information about presentation that could modify precautionary measures for infants born of mothers with a remote history of COVID-19. Methods: We report two infants with possible maternofetal transmission, and four mothers without immunologic reactions. Data were collected from the patient files. Results: One mother exhibited infection signs 10 days before uncomplicated delivery, with negative RT-PCR and no antibody detection thereafter. Another mother exhibited infection 6 weeks pre-delivery, confirmed by nasopharyngeal swab testing with positive RT-PCR, and positive antibody detection (IgM and IgG). Both newborns were asymptomatic but tested positive for nasopharyngeal and stool RT-PCR at 1 and 3 days of age for the first one and at 1 day of age for stool analysis for the second one. Two additional mothers exhibited infection confirmed by positive RT-PCR testing at 28- and 31-days pre-delivery but did not present detectable antibody reaction at the time of delivery. Conclusion: These observations raise concerns regarding contamination risk by asymptomatic newborns and the efficacy of immunologic reactions in pregnant mothers, questioning the reliability of antibody testing during pregnancy.
Arthroscopic Resection for Benign Fibrous Histiocytoma in the Epiphysis of the Femur
Authors: Junya Shimizu, Makoto Emori, Yohei Okada, Tadashi Hasegawa, Toshihiko Yamashita
Journal: Case Rep Orthop (2018)
MeSH terms: Case Reports

A 16-year-old woman presented to her local hospital with a few-month history of right knee pain. On MRI, the lesion exhibited an intermediate signal on T1-weighted and T2-weighted images. The orthopedic physician made a diagnosis of osteochondritis dissecans. After 13 months from the first visit, the patient underwent MRI of the knee once more, which demonstrated that the osteolytic lesion grew larger. To achieve a definitive diagnosis, we attempted to perform a resection biopsy with knee arthroscopy. We performed biopsy, and the tumor was removed completely. The tumor occurred in an epiphysis, and the pathological findings concluded that the pathological diagnosis was benign fibrous histiocytoma. One year after surgery, she was asymptomatic. Computed tomography revealed that the previous tumor bone cavity was filled with bone formation and no evidence of recurrence.
Reparo de aneurisma de artéria ilíaca roto em criança
Authors: Fernando Massaru Hoshiko, Elisa Helena Subtil Zampieri, Marcelo Bellini Dalio, Nei Rodrigues Alves Dezotti, Edwaldo Edner Joviliano
Journal: J Vasc Bras (2017)
MeSH terms: Case Reports

Abstract:
We describe the case of a 12-year-old girl who presented at the emergency department with hemorrhagic acute abdomen, an abdominal pulsating mass and hemodynamic instability. A diagnosis of ruptured right iliac artery aneurysm was confirmed and an emergency open repair procedure was performed with extra-anatomic reconstruction, using a small-caliber synthetic graft, compatible with her anatomy. The treatment was successful and the child was doing well at short-term follow-up.
Computational Hemodynamic Analysis for the Diagnosis of Atherosclerotic Changes in Intracranial Aneurysms: A Proof-of-Concept Study Using 3 Cases Harboring Atherosclerotic and Nonatherosclerotic Aneurysms Simultaneously
Authors: Shin-Ichiro Sugiyama, Hidenori Endo, Kuniyasu Niizuma, Toshiki Endo, Kenichi Funamoto, Makoto Ohta, Teiji Tominaga
Journal: Comput Math Methods Med (2016)
MeSH terms: Atherosclerosis / physiopathology, Hemodynamics, Intracranial Aneurysm / physiopathology, Case Reports, Aged, Arteries / physiopathology, Atherosclerosis / complications, Cerebral Angiography, Computer Simulation, Female, Humans, Hydrodynamics, Imaging, Three-Dimensional, Intracranial Aneurysm / complications, Lipids / chemistry, Magnetic Resonance Imaging, Male, Microscopy, Phase-Contrast, Middle Aged, Models, Statistical, Oscillometry, Protein Domains, Shear Strength, Stress, Mechanical, Lipids

This was a proof-of-concept computational fluid dynamics (CFD) study designed to identify atherosclerotic changes in intracranial aneurysms. We selected 3 patients with multiple unruptured aneurysms including at least one with atherosclerotic changes and investigated whether an image-based CFD study could provide useful information for discriminating the atherosclerotic aneurysms. Patient-specific geometries were constructed from three-dimensional data obtained using rotational angiography. Transient simulations were conducted under patient-specific inlet flow rates measured by phase-contrast magnetic resonance velocimetry. In the postanalyses, we calculated time-averaged wall shear stress (WSS), oscillatory shear index, and relative residence time (RRT). The volume of blood flow entering aneurysms through the neck and the mean velocity of blood flow inside aneurysms were examined. We applied the age-of-fluid method to quantitatively assess the residence of blood inside aneurysms. Atherosclerotic changes coincided with regions exposed to disturbed blood flow, as indicated by low WSS and long RRT. Blood entered aneurysms in phase with inlet flow rates. The mean velocities of blood inside atherosclerotic aneurysms were lower than those inside nonatherosclerotic aneurysms. Blood in atherosclerotic aneurysms was older than that in nonatherosclerotic aneurysms, especially near the wall. This proof-of-concept study demonstrated that CFD analysis provided detailed information on the exchange and residence of blood that is useful for the diagnosis of atherosclerotic changes in intracranial aneurysms.
Case Report: Hyperplastic Callus of the Femur Mimicking Osteosarcoma in Osteogenesis Imperfecta Type V
Authors: Ying Deng, Yanan Huo, Jinfeng Li
Journal: Front Endocrinol (Lausanne) (2021)
Keywords: bony callus, osteogenesis imperfecta, osteosarcoma, pathology, type v
MeSH terms: Bony Callus / diagnostic imaging, Femur / diagnostic imaging, Osteogenesis Imperfecta / diagnostic imaging, Osteosarcoma / diagnostic imaging, Case Reports, Research Support, Non-U.S. Gov't, Adolescent, Bony Callus / pathology, Diagnosis, Differential, Femur / pathology, Humans, Magnetic Resonance Imaging, Male, Osteogenesis Imperfecta / pathology, Osteosarcoma / pathology

Background:
Osteogenesis imperfecta (OI) type V is a rare form of OI which is often characterized by hyperplastic callus. Misdiagnosis is a possibility due to its rarity and because patients involved are mostly in adolescence, a predisposing age for osteosarcoma. Here, we report this case and aim to improve understanding of patients with OI type V and avoid misdiagnosis.
Case presentation:
A male, 14-year-old patient was admitted to Jiangxi Provincial People's Hospital affiliated to Nanchang University in August 2020 due to repeated fractures for more than 11 years and swelling in his right leg for more than 4 years. The patient was diagnosed with OI in 2014 due to repeated fracture and was treated with bisphosphonates. The swelling was accompanied by huge callus formation. Prior to admission to our hospital in 2016 osteosarcoma was suspected by imaging and pathology, and amputation was recommended. OI-V was confirmed after more than four years of follow-up and genetic diagnosis, and the affected limb was preserved.
Conclusion:
The history of OI and lack of rapid progression suggested OI-V with a hyperplastic callus. Combined with genetic testing, the diagnosis was OI-V. Although the patient was at a predisposing age for osteosarcoma, diagnosis and treatment should be based on the medical history of the patient, imaging,and genetic testing, and sometimes even time-consuming retrospective observation.
Intralobar pulmonary sequestration with bronchial atresia and a systemic artery feeding a normal contralateral lung
Authors: Marica Giannotta, Maria Barbara Leone, Laura Greco, Michelangelo Baldazzi, Maurizio Zompatori
Journal: BJR Case Rep (2015)
MeSH terms: Case Reports

We report a case of an intralobar pulmonary sequestration in the left lower lobe presenting with aspects of bronchial atresia associated with an anomalous systemic artery supplying the basal segments of the right lower lobe, which showed no bronchial or parenchymal anomalies. This is an extremely rare occurrence and has been reported only twice in the literature so far.
A Case Report of Leptomeningeal Myelomatosis and Rapid Improvement with Regimen Consisting of Daratumumab, Pomalidomide, Vincristine, Procarbazine, and Dexamethasone
Authors: Jew Win Kuan, Sing Ling Chai, Pathmanathan Rajadurai, Lee Gong Lau, Joseph Uchang, Sharifah Noor Akmal Syed Husain
Journal: Case Rep Hematol (2022)
MeSH terms: Case Reports

Central nervous system (CNS) involvement in multiple myeloma (MM) (MM-CNS) in the form of leptomeningeal myelomatosis or brain parenchyma plasmacytoma is rare, causing challenges in clinical diagnosis and treatment. We would like to report a case of leptomeningeal myelomatosis and illustrated the challeges. A 61-year-old man was diagnosed with MM with left paravertebral plasmacytoma, R-ISS II with high suspicion of double-hit MM, either biallelic aberrancy of TP53 or del(17p) and IGH aberrancy depending on the definition chosen, treated with lenalidomide-bortezomib-dexamethasone and local radiotherapy, later developed systemic relapse and progression to MM-CNS in the form of leptomeningeal myelomatosis. A modified CNS-based treatment not reported before, consisting of daratumumab, pomalidomide, vincristine, procarbazine, and dexamethasone, brought a rapid clinical improvement and warrants a further study. Incorporation of intrathecal thiotepa into the regimen would likely increase the efficacy.