OpenMed/multicare-articles huggingface dataset:
Retroperitoneal schwannoma sandwiched between abdominal aorta and inferior vena cava. A case report
Authors: Pramod Nepal, Yuko Mataki, Kosei Maemura, Hiroshi Kurahara, Kiyonori Tanoue, Yota Kawasaki, Tetsuya Idichi, Yuto Hozaka, Satoshi Iino, Shinichiro Mori, Hiroyuki Shinchi, Shoji Natsugoe
Journal: Int J Surg Case Rep (2020)
Keywords: case report, preoperative diagnosis of schwannoma, retroperitoneal schwannoma
MeSH terms: Case Reports

Introduction:
Schwannomas are tumors that originate from the Schwann cells present in the nerve sheath of peripheral nerves. They are commonly seen in cephalocervical areas. Schwannomas in the abdominal cavity are rare. Here, we discuss a case of retroperitoneal schwannoma lying dorsal to pancreas with critical relations to surrounding vessels.
Presentation of case:
A 74 years old asymptomatic male was found with elevated amylase level on his routine blood examination. MR imaging revealed retroperitoneal mass of size 21*18*24 mm. EUS-FNA confirmed retroperitoneal schwannoma. The patient had co-morbid renal disease and was on hemodialysis. During the latest follow up, the tumor was 41*37*41 mm in size located dorsal to the confluence of right renal vein and inferior vena cava. The tumor was in contact with inferior vena cava, horizontal part of duodenum, right renal artery, right kidney, and adrenal gland. The patient underwent laparotomy and the tumor was extract with intact capsule. There were no post-operative complications.
Discussion:
Pre-operative diagnosis in retroperitoneal schwannomas is challenging because imaging features are usually non-specific, and biopsy is the only diagnostic technique. EUS-FNA, which has low diagnostic accuracy, is useful in pre-operative diagnosis of small tumors devoid of intra-tumoral degeneration.
Conclusion:
Retroperitoneal schwannoma is a rare entity. Preoperative diagnosis and curative resection are technically difficult. Care should be given during preoperative investigations and surgical resection of the tumor. EUS-FNA can be a useful diagnostic tool.
Actinic keratosis underlying cutaneous horn at an unusual site-a case report
Authors: Pragya A Nair, Arvind H Chaudhary, Malay J Mehta
Journal: Ecancermedicalscience (2013)
Keywords: actinic keratosis, cornucutaneum, cutaneous horn
MeSH terms: Case Reports

Cutaneous horns are usually found on chronic sun-damaged skin. A cutaneous horn is a rare tumour, often conical, circumscribed, and composed of dead keratin usually derived from base keratinocytes. It occurs mainly in association with underlying benign, premalignant, and malignant cutaneous diseases. The commonest malignancy is squamous cell carcinoma. Thus, to accurately ascertain the nature of the condition at the base of the lesion and to rule out malignancy, an excision biopsy is indicated. Here, we report a case of cutaneous horn over the palmar aspect of the left middle finger in a 45-year-old man whose histopathology showed actinic keratosis.
Successful every-other-day liothyronine therapy for severe resistance to thyroid hormone beta with a novel THRB mutation; case report
Authors: Yoshihiro Maruo, Asami Mori, Yoriko Morioka, Chihiro Sawai, Yu Mimura, Katsuyuki Matui, Yoshihiro Takeuchi
Journal: BMC Endocr Disord (2016)
MeSH terms: Mutation, Thyroid Hormone Receptors beta / genetics, Thyroid Hormone Resistance Syndrome / drug therapy, Thyroid Hormone Resistance Syndrome / genetics, Triiodothyronine / therapeutic use, Case Reports, Research Support, Non-U.S. Gov't, Base Sequence, Child, Congenital Hypothyroidism / genetics, DNA Mutational Analysis, Female, Hormone Replacement Therapy, Humans, Molecular Sequence Data, Severity of Illness Index, Treatment Outcome, Thyroid Hormone Receptors beta, Triiodothyronine

Background:
Resistance to thyroid hormone beta (RTHβ) is a rare and usually dominantly inherited syndrome caused by mutations of the thyroid hormone receptor β gene (THRB). In severe cases, it is rarely challenging to control manifestations using daily therapeutic replacement of thyroid hormone.
Case presentation:
The present case study concerns an 8-year-old Japanese girl with a severe phenotype of RTH (TSH, fT3, and fT4 were 34.0 mU/L, >25.0 pg/mL and, >8.0 ng/dL, respectively), caused by a novel heterozygous frameshift mutation in exon 10 of the thyroid hormone receptor beta gene (THRB), c.1347-1357 del actcttccccc : p.E449DfsX11. RTH was detected at the neonatal screening program. At 4 years of age, the patient continued to suffer from mental retardation, hyperactivity, insomnia, and reduced resting energy expenditure (REE), despite daily thyroxine (L-T4) therapy. Every-other-day high-dose liothyronine (L-T3) therapy improved her symptoms and increased her REE, without thyrotoxicosis.
Conclusion:
In a case of severe RTH, every-other-day L-T3 administration enhanced REE and psychomotor development, without promoting symptoms of thyrotoxicosis. Every-other-day L-T3 administration may be an effective strategy for the treatment of severe RTH.
The therapeutic effect of glucocorticoids on type II respiratory failure, heart failure, and massive pericardial effusion caused by hypothyroidism: A case report
Authors: Jingyue Wang, Xiangjun Li, Botao Shen, Shipeng Wang, Jiahuan He, Yushi Wang
Journal: Front Pharmacol (2022)
Keywords: dyspnea, glucocorticoids, hypothyroidism, heart failure, invasive ventilator assisted ventilation, severe case report, type ii respiratory failure
MeSH terms: Case Reports

Background: Hypothyroidism is a disease commonly observed in outpatient clinics but can occasionally cause severe cardiovascular and respiratory diseases requiring hospitalization. Case report: The patient reported herein suffered from heart failure, massive pericardial effusion, type II respiratory failure, and hypothyroidism. There was no related basic diseases of respiratory and cardiovascular system in the past. She failed to be weaned from invasive ventilation multiple times after routine treatment and was finally successfully weaned on day five of receiving the combination therapy of a high-dose methylprednisolone intravenous drip and levothyroxine oral administration. Conclusion: This case report indicates that hypothyroidism may be a cause of type II respiratory failure, heart failure, and massive pericardial effusion without cardiac tamponade and that a combination of levothyroxine and corticosteroids could effectively treat the disease. Clinical workers should consider the role of thyroid function in diagnosis, and the admission team should include this aspect in the monitoring scope. Moreover, the role of hormones in the treatment of patients with severe hypothyroidism should not be ignored, and timely treatment should be provided.
Prenatal diagnosis and postnatal management of congenital mesoblastic nephroma: A case report and literature review
Authors: Xiaoxiao Zhang, Huijing Zhang, Shuang Wang, Yangxu Gao, Li Liang, Huixia Yang
Journal: Front Pediatr (2022)
Keywords: classic, congenital mesoblastic nephroma (cmn), nephrorectomy, prenatal ultrasound, solid renal mass
MeSH terms: Case Reports

Background:
Congenital mesoblastic nephroma (CMN) is a rare renal tumour in children, the most common kidney tumour in the neonatal period. It can be divided into three types, classical, cellular and mixed.
Case presentation:
A 31-year-old Chinese woman had no apparent foetal abnormality in regular prenatal care during the first and second trimesters. At 33 weeks of gestation, a solid mass in the right kidney was noted with echoes similar to liver and hypervascularity. It grew larger during late pregnancy. The infant was transferred to have a radical nephrectomy on the 9th day after birth. The postoperative histopathological result indicated classical CMN.
Conclusion:
CMN could be detected prenatally, mainly during late pregnancy. The postnatal outcome is good.
Preclinical polymodal hallucinations for 13 years before dementia with Lewy bodies
Authors: Carlo Abbate, Pietro Davide Trimarchi, Silvia Inglese, Niccolò Viti, Alessandra Cantatore, Lisa De Agostini, Federico Pirri, Lorenza Marino, Renzo Bagarolo, Daniela Mari
Journal: Behav Neurol (2014)
MeSH terms: Hallucinations / diagnosis, Lewy Body Disease / diagnosis, Prodromal Symptoms, Case Reports, Aged, 80 and over, Disease Progression, Female, Hallucinations / psychology, Humans, Lewy Body Disease / psychology, Neuropsychological Tests

Objective:
We describe a case of dementia with Lewy bodies (DLB) that presented long-lasting preclinical complex polymodal hallucinations.
Background:
Few studies have deeply investigated the characteristics of hallucinations in DLB, especially in the preclinical phase. Moreover, the clinical phenotype of mild cognitive impairment-(MCI-) DLB is poorly understood.
Methods:
The patient was followed for 4 years and a selective phenomenological and cognitive study was performed at the predementia stage.
Results:
The phenomenological study showed the presence of hypnagogic and hypnopompic hallucinations that allowed us to make a differential diagnosis between DLB and Charles Bonnet syndrome (CBS). The neuropsychological evaluation showed a multiple domain without amnesia MCI subtype with prefrontal dysexecutive, visuoperceptual, and visuospatial impairments and simultanagnosia, which has not previously been reported in MCI-DLB.
Conclusions:
This study extends the prognostic value of hallucinations for DLB to the preclinical phases. It supports and refines the MCI-DLB concept and identifies simultanagnosia as a possible early cognitive marker. Finally, it confirms an association between hallucinations and visuoperceptual impairments at an intermediate stage of the disease course and strongly supports the hypothesis that hallucinations in the earliest stages of DLB may reflect a narcolepsy-like REM-sleep disorder.
A Patient With a Chronic Cough: An Unexpected Case of Calcium Pill Aspiration
Authors: Pooja Poudel, Andrew Chu, Kanish Mirchia, Manju Paul
Journal: J Investig Med High Impact Case Rep (2019)
Keywords: calcium pill aspiration, chronic cough
MeSH terms: Bronchi, Cough / etiology, Foreign Bodies / complications, Respiratory Aspiration / complications, Tablets / adverse effects, Case Reports, Aged, Bronchoscopy, Calcium / administration & dosage, Chronic Disease, Delayed Diagnosis, Female, Humans, Tomography, X-Ray Computed, Tablets, Calcium

Foreign body aspiration is a life-threatening medical condition that requires prompt action. Delayed diagnosis is associated with long-term serious complication often leading to death. In adults, it can remain undetected for a long period of time. The patient gives a long history of a cough, which clinicians often ignore. A chest radiograph is unreliable to exclude the disease as it may not show radiolucent objects. Diagnostic bronchoscopy is necessary to exclude the disease. We report a case of 70-year-old woman who had a 1-month history of a cough and was admitted for shortness of breath, and on further evaluation, we incidentally detected calcium tablets in her bronchus. The present case demonstrates the need for early bronchoscopy especially when the cause of a chronic cough is not known.
Use of savolitinib as neoadjuvant therapy for non-small cell lung cancer patient with MET exon 14 skipping alterations: A case report
Authors: Yu Zhang, Hao Zhang, Hanqing Wang, Jingtong Zeng, Bo Zhang, Ning Zhou, Lingling Zu, Zuoqing Song, Changli Wang, Song Xu
Journal: Front Oncol (2022)
Keywords: met exon 14 skipping, nsclc, neoadjuvant, savolitinib, targeted therapy
MeSH terms: Case Reports

Savolitinib is a tyrosine kinase inhibitor being developed for the treatment of metastatic non-small cell lung cancer (NSCLC) with mesenchymal-epithelial transition (MET) factor exon 14 skipping alterations. However, the role of savolitinib in neoadjuvant therapy for lung cancer remains unclear. Here, we present a case of a 65-year-old woman diagnosed with stage IIIA (cT2bN2M0, eighth TNM stage) upper right lung adenocarcinoma harboring MET exon 14 skipping alterations. After 4 weeks of therapy, a partial response was achieved with neoadjuvant savolitinib, and significant shrinkage in tumor and lymph nodes was observed. We also measured the immune microenvironment of the primary tumor pre- and posttreatment with savolitinib.
Acute Thrombocytopenia, Leucopenia, and Multiorgan Dysfunction: The First Case of SFTS Bunyavirus outside China?
Authors: Srdjan Denic, Joumana Janbeih, Suresh Nair, Walter Conca, Waheed Uz Zaman Tariq, Suhail Al-Salam
Journal: Case Rep Infect Dis (2011)
MeSH terms: Case Reports

We report a 57-year-old man with acute thrombocytopenia, leucopenia, and multiorgan dysfunction. Patient was from North Korea and was temporarily working in Dubai, United Arab Emirates, when he fell ill in March 2009. At the same time and unknown to us, many patients with similar clinical manifestations were admitted to hospitals in China. The Chinese cases-identified between March and July 2009-were recently reported to have been infected with a tick-born strain of bunyavirus, a new disease. The virus infection was documented in patients from central China and the region that shares the border with North Korea. The clinical manifestations, the time of disease onset, and geographical link of the patient with the region in which the disease is endemic suggest that the patient had SFTS bunyavirus infection.
Angioid streaks - a rare cause of neovascular glaucoma. Case report
Authors: E Ungureanu, A Geamanu, I Careba, M Grecescu, S Gradinaru
Journal: J Med Life (2014)
Keywords: bevacizumab, angioid streaks, neovascular glaucoma
MeSH terms: Angioid Streaks / complications, Glaucoma, Neovascular / etiology, Case Reports, Female, Fovea Centralis / pathology, Humans, Macular Edema / complications, Middle Aged

Rationale. Neovascular glaucoma is the type of glaucoma most refractory to treatment. The most frequent causes are those associated with retinal hypoxia, such as proliferative diabetic retinopathy, central retinal vein occlusion, branch retinal vein occlusion, central retinal arterial occlusion, ischemic ocular syndrome etc. Rare causes of neovascular glaucoma are multiple and are due to VEGF synthesis associated with chorioretinal inflammations or degenerations. We present a case with neovascular glaucoma associated with an extremely rare cause, angioid streaks Objective. The objective of our prsentation was to asses efficacy of the 5-FU associated trabeculectomy following bevacizumab intravitreal administration Methods and results. Case report of a 48 years old female patient which presented at the emergency room with painful red left eye. At presentation best corrected left eye visual acuity was 1/10, intraocular pressure was 36 mm Hg. Examination established the diagnosis of Neovascular glaucoma associated with angioid streaks. After intravenous Manitol, oral Acetazolamide and topical treatment with fixed combination timolol-brinzolamide, topical steroid and mydriatic intraocular pressure decreased. Intravitreal bevacizumab injection was performed, followed after 3 weeks by trabeculectomy. Discussion. Angioid streaks are an extremely rare cause of neovascular glaucoma. The treatment is similar to the treatment for other causes of neovascular glaucoma.
Familial tuberculosis mimicking advanced ovarian cancer
Authors: Fakhrolmolouk Yassaee, Farah Farzaneh
Journal: Infect Dis Obstet Gynecol (2009)
MeSH terms: Ovarian Neoplasms / diagnosis, Tuberculosis, Female Genital / diagnosis, Case Reports, Adult, Diagnosis, Differential, Female, Histocytochemistry, Humans, Middle Aged, Ovarian Neoplasms / pathology, Tuberculosis, Female Genital / pathology

Genital TB may present as on abdominopelvic mass mimicking ovarian malignancy because clinical and laboratory findings are similar. Family history is very important and should be considered for differential diagnosis. Three cases of genital TB with presentation of abdominopelvic masses and with no signs and symptoms of TB were presented. Two of them had positive family history of pulmonary TB. Tissue diagnosis was the best method for diagnosis of genital TB, but it should be reminded that if positive family history of TB was present, mini laparotomy should be done to take biopsy and to make rapid diagnosis before treatment.
Haemorrhagic cystitis due to BK virus in a child with ALL on standard chemotherapy without stem cell transplant
Authors: Samin Alavi, Mohammad Kaji Yazdi, Mahmoud Parvin, Farahnaz Zohrehbandian, Roxana Azma
Journal: Ecancermedicalscience (2013)
Keywords: bk virus, acute leukaemia, chemotherapy, haemorrhagic cystitis, nontransplantation
MeSH terms: Case Reports

The BK virus (BKV) is a nonenveloped double-stranded DNA virus of the polyomavirus family that primarily affects immunocompromised people. BKV infects humans at an early age. Initial infections with BKV are mainly asymptomatic and usually remain latent in the brain, peripheral blood, kidneys, and urothelium. Following the primary infection, viruses persist indefinitely as 'latent' infections of the kidney and urinary system because the virus is urotheliotropic. Reactivation of the virus infections occurs in individuals with severe immunosuppression states such as kidney and stem cell transplantation and rarely in pregnancy. In this line, BKV has been implicated as a common cause of late-onset haemorrhagic cystitis (HC) in patients who have undergone stem cell transplantation. In contrast, reports of BKV-associated diseases in nontransplant paediatric patients are almost exclusively in patients with human immunodeficiency virus infection. Herein, we report the first case of a child with acute lymphoblastic leukaemia who developed BKV-associated HC without receiving stem cell transplantation while on standard maintenance chemotherapy.
Joubert syndrome in three children in a family: a case series
Authors: Javad Akhondian, Farah Ashrafzadeh, Mehran Beiraghi Toosi, Nasrin Moazen, Toktam Mohammadpoor, Reza Karami
Journal: Iran J Child Neurol (2013)
Keywords: joubert syndrome, molar tooth sign, vermian dysgenesis
MeSH terms: Case Reports

Joubert syndrome (JS) is a rare autosomal recessive central nervous system malformation characterized by hypoplasia of the cerebellar vermis, hypotonia and abnormal psychomotor development, along with altered respiratory pattern and various ophthalmologic features. Here, we describe three children with Joubert syndrome in a family that had almost similar presentations, including ataxia, developmental delay, mental retardation and ocular disorders. Prevalence of Joubert syndrome is about 1 in 100,000 live birth. It may be accompanied by other organs' disorders. The molar tooth sign is pathognomonic for joubert syndrome that is ascertained by brain MRI.
Atypical emphysema formation in a never-smoker with scleroderma-related interstitial pneumonia: a case report
Authors: Rahma Ben Jazia, Jihene Ayachi, Raja Ghzel, Ameni Kacem, Iteb Ben Limem, Amira Faidi, Dhouha Ben Braiek, Farouk Chatbouri, Anis Maatallah
Journal: Pan Afr Med J (2022)
Keywords: systemic sclerosis, case report, combined-pulmonary emphysema, lung fibrosis
MeSH terms: Emphysema, Lung Diseases, Interstitial / diagnostic imaging, Lung Diseases, Interstitial / etiology, Pulmonary Emphysema / diagnostic imaging, Pulmonary Emphysema / etiology, Scleroderma, Localized, Scleroderma, Systemic / complications, Case Reports, Adult, Female, Fibrosis, Humans, Male, Smokers

Scleroderma is an autoimmune connective tissue disorder which is characterized by fibrosis of visceral organs, blood vessels and skin. The most common manifestations of lung disease in systemic sclerosis are interstitial lung disease and pulmonary hypertension and, together, are the leading cause of mortality in systemic sclerosis. Recently, we notice a new pattern called Combined-pulmonary emphysema and lung fibrosis. Most patients with this entity are male smokers or ex-smokers. This entity is characterized by the coexistence of both centro-lobular and para-septal emphysema in the upper lobes and interstitial lung disease in the lower lobes. Here, we present a case of a nonsmoker adult woman with systemic sclerosis, in which High Resolution Computed Tomography of lung showed combined fibrosis and emphysema with atypical radiological presentation and unusual distribution. This case outlines the importance of recognizing the presence of combined fibrosis and emphysema in patient with systemic sclerosis even without smoking history.
Asymmetric Expansion with a Modified Quad Helix for Treatment of Isolated Crossbite
Authors: Marisabel Magnifico, Alberto Di Blasio, Diana Cassi, Chiara Di Blasio, Mauro Gandolfini
Journal: Case Rep Dent (2017)
MeSH terms: Case Reports

Unilateral posterior crossbite often involves only one tooth, especially upper first molar; in these cases it is never easy to obtain an asymmetrical movement of a molar and a proper planning of the orthodontic device with its anchorage is necessary to avoid arch overexpansion. Thanks to its simplicity and efficacy, the modified Quad Helix here described represents a valid therapeutic tool in cases of isolated posterior crossbite.
Perforated Appendicitis with Peri-Appendicular Abscess in an Amyand's Hernia
Authors: Ruquia Khatoon, Yousuf Aziz Khan, Nasir Salim Saddal
Journal: APSP J Case Rep (2013)
Keywords: amyand’s hernia, perforated appendix, peri-appendicular abscess
MeSH terms: Case Reports

Amyand's hernia is a rare clinical condition in which a normal or an inflamed appendix lies in the inguinal hernial sac. Perforated appendicitis in an Amyand's hernia is even more uncommon. Herein we report such a rare case in a 4 month old baby who presented with an irreducible right inguino-scrotal swelling. Exploration revealed perforated appendix in the hernial sac with local abscess. A transherniotomy appendectomy was done. Postoperatively, the patient developed wound infection, which resolved with wound care. Pediatric / hernia surgeons must remember this rare clinical situation while managing children with acute right inguino-scrotal swellings.
Case Report: Multimodal Imaging Guides the Management of an Eosinophilic Leukemia Patient With Eosinophilic Myocarditis and Intracardiac Thrombus
Authors: Jinping Si, Xinxin Zhang, Na Chen, Fangfang Sun, Ping Du, Zhiyong Li, Di Tian, Xiuli Sun, Guozhen Sun, Tao Cong, Xuemei Du, Ying Liu
Journal: Front Cardiovasc Med (2022)
Keywords: 18f-fapi, pet/ct, eosinophilic leukemia, fibroblast activation protein, thrombotic
MeSH terms: Case Reports

Background:
Eosinophilic leukemia (EL) is a rare, serious and potentially life-threatening condition characterized by the overproduction of eosinophils leading to tissue eosinophilic infiltration and damage. Although multiple organ systems may be involved, progressive eosinophilic myocarditis (EM) is the most common cause of morbidity and mortality. Early diagnosis and follow-up surveillance combined with multimodal imaging are crucial for appropriate treatment of EM.
Case summary:
It's a rare case of EL with EM and intracardiac thrombus in a 59-year-old patient who presented with asthenia for 3 weeks. Full blood count analysis indicated significant eosinophilia. Bone marrow aspirate revealed dysplastic eosinophilia and a FIP1L1-PDGFRA fusion gene (4q12) was detected, confirming EL. Echocardiography revealed EM with intracardiac thrombus. This was later confirmed by cardiac magnetic resonance imaging. The patient was commenced on imatinib and prednisolone and good clinical response was obtained. Through 18F-FAPI PET/CT imaging, we obtained in vivo visualization of fibroblast activation changes in the early stage of cardiac structure remodeling. With anti-fibrotic therapy after heart failure, the patient achieved a good clinical response.
Conclusion:
This case demonstrates in vivo visualization of fibroblast activation after EM. Multimodality imaging can provide early diagnosis and may guide tailored antifibrotic therapy in early stage of EM.