OpenMed/multicare-articles huggingface dataset:
Integration of HPV6 and downregulation of AKR1C3 expression mark malignant transformation in a patient with juvenile-onset laryngeal papillomatosis
Authors: Christian Ulrich Huebbers, Simon Florian Preuss, Jutta Kolligs, Julia Vent, Markus Stenner, Ulrike Wieland, Steffi Silling, Uta Drebber, Ernst-Jan M Speel, Jens Peter Klussmann
Journal: PLoS One (2013)
MeSH terms: 3-Hydroxysteroid Dehydrogenases / genetics, Carcinoma / genetics, Cell Transformation, Neoplastic / genetics, Human papillomavirus 6 / genetics, Hydroxyprostaglandin Dehydrogenases / genetics, Laryngeal Neoplasms / genetics, Papilloma / genetics, Case Reports, Research Support, Non-U.S. Gov't, Adult, Age of Onset, Aldo-Keto Reductase Family 1 Member C3, Carcinoma / pathology, Cell Transformation, Neoplastic / pathology, Cyclin-Dependent Kinase Inhibitor p16 / genetics, Down-Regulation, Fatal Outcome, Female, Human papillomavirus 6 / pathogenicity, Humans, Laryngeal Neoplasms / pathology, Papilloma / pathology, Retinoblastoma Protein / genetics, Tumor Suppressor Protein p53 / genetics, Cyclin-Dependent Kinase Inhibitor p16, Retinoblastoma Protein, Tumor Suppressor Protein p53, 3-Hydroxysteroid Dehydrogenases, Hydroxyprostaglandin Dehydrogenases, AKR1C3 protein, human, Aldo-Keto Reductase Family 1 Member C3, Laryngeal papillomatosis

Juvenile-onset recurrent respiratory papillomatosis (RRP) is associated with low risk human papillomavirus (HPV) types 6 and 11. Malignant transformation has been reported solely for HPV11-associated RRP in 2-4% of all RRP-cases, but not for HPV6. The molecular mechanisms in the carcinogenesis of low risk HPV-associated cancers are to date unknown. We report of a female patient, who presented with a laryngeal carcinoma at the age of 24 years. She had a history of juvenile-onset RRP with an onset at the age of three and subsequently several hundred surgical interventions due to multiple recurrences of RRP. Polymerase chain reaction (PCR) or bead-based hybridization followed by direct sequencing identified HPV6 in tissue sections of previous papilloma and the carcinoma. P16(INK4A), p53 and pRb immunostainings were negative in all lesions. HPV6 specific fluorescence in situ hybridization (FISH) revealed nuclear staining suggesting episomal virus in the papilloma and a single integration site in the carcinoma. Integration-specific amplification of papillomavirus oncogene transcripts PCR (APOT-PCR) showed integration in the aldo-keto reductase 1C3 gene (AKR1C3) on chromosome 10p15.1. ArrayCGH detected loss of the other gene copy as part of a deletion at 10p14-p15.2. Western blot analysis and immunohistochemistry of the protein AKR1C3 showed a marked reduction of its expression in the carcinoma. In conclusion, we identified a novel molecular mechanism underlying a first case of HPV6-associated laryngeal carcinoma in juvenile-onset RRP, i.e. that HPV6 integration in the AKR1C3 gene resulted in loss of its expression. Alterations of AKR1C gene expression have previously been implicated in the tumorigenesis of other (HPV-related) malignancies.
Successful treatment with docetaxel plus nintedanib in a patient with lung adenocarcinoma and pulmonary fibrosis: A case report and literature review
Authors: Tanya Zlatanova, Jeliazko Arabadjiev, Galina Kirova-Nedyalkova, Diana Nikova
Journal: Front Oncol (2022)
Keywords: case report, docetaxel, idiopathic pulmonary fibrosis, lung carcinoma, nintedanib
MeSH terms: Case Reports

Despite the rare incidence of idiopathic pulmonary fibrosis (IPF), coexisting IPF and lung cancer is common. Both diseases have unfavorable outcomes and are often associated with impaired quality of life. In this study, we present a clinical case of a patient with coexisting IPF and lung adenocarcinoma who was successfully treated with nintedanib plus docetaxel as a second-line treatment, and achieved a substantial improvement in the quality of life. To our knowledge, very few cases in the literature address the concurrent treatment of both diseases, which makes this case a valuable illustration of a successful treatment strategy and a basis for future investigations.
Adult ADHD: Questioning Diagnosis and Treatment in a Patient with Multiple Psychiatric Comorbidities
Authors: Robert Karoly Chu, Tea Rosic, Zainab Samaan
Journal: Case Rep Psychiatry (2017)
MeSH terms: Case Reports

Adult Attention-Deficit/Hyperactivity Disorder (ADHD) is a contentious diagnostic issue, which has been increasing in prevalence in recent years, and is often comorbid with other psychiatric disorders. This report presents a detailed account of a clinical case involving a middle-aged man with a history of recurrent depressive episodes and an unsubstantiated diagnosis of ADHD, treated with stimulants. There is persistent debate around the use of psychostimulants both in adult ADHD and in the treatment of depression. Despite promising activating properties, psychostimulants carry significant risks of misuse and substance use disorder. In this report, we consider the potential benefits and adverse effects of stimulants in the treatment of adult ADHD and mood disorders and review the learning points of this complicated, but not uncommon, clinical case.
Advanced epithelioid malignant peripheral nerve sheath tumor showing complete response to combined surgery and chemotherapy: a case report
Authors: Tomohiro Minagawa, Ryuta Shioya, Chigusa Sato, Ryuji Shichinohe, Go Yasui, Kohsuke Ishikawa, Hiroko Takahashi
Journal: Case Rep Oncol Med (2011)
MeSH terms: Case Reports

Malignant peripheral nerve sheath tumor (MPNST) is a rare high-grade soft tissue sarcoma. The epithelioid variant accounts for 5% or less of MPNSTs; the clinical behavior of this variant is unclear. Reports of approximately 40 cases are available in the English literature; however, most reports addressed clinicopathological features rather than therapeutic procedures or clinical courses. We describe a case of a 62-year-old male with an epithelioid MPNST of the left foot. Multiple lung metastases developed after radical surgery on the primary lesion. The response to adjuvant chemotherapy including doxorubicin and ifosfamide was favorable, and thoracoscopic resection was subsequently performed on the remaining three metastases. No evidence of recurrence or metastasis was observed at the 12-month followup after the first operation. Further followup and chemotherapy may be required.
The outcome of kyphosis tuberculosis treated with one stage reconstruction surgery. A case series
Authors: Fachrisal, Luthfi Gatam, Asrafi Rizki Gatam, Aji Antoro
Journal: Int J Surg Case Rep (2019)
Keywords: anterior column reconstruction, kyphotic deformity, modified lateral extracavitary approach

Introduction:
Commonly, two stage combined anterior - posterior approaches were performed to treat significant kyphotic deformity, but potentially increase morbidity level. Recently, single - stage posterior approach for anterior column reconstruction have shown sagittal alignment improvement. The objective of this study is to describe a series of kyphotic deformity patients whom were treated using modified lateral extracavitary approach for anterior column reconstruction and posterior instrumentation.
Methods:
Data collected from all kyphotic deformity patients whom treated with modified lateral extracavitary approach between 2016 until 2017 and this research work has been reported in line with the PROCESS criteria. In addition this technique could address kyphotic correction.
Results:
7 patients were reported, 4 males and 3 females with local and regional kyphotic more than 40 degrees. Procedures performed mostly on the right side to avoid the aorta with approximately 2 cm of the rib distal to the transverse processes. The average estimated blood loss and length of surgery were 1280 ml and 3.9 h. None of the patient had neurological deficit, and all of them have shown kyphotic improvement.
Conclusion:
The modified lateral extracavitary approach for anterior column reconstruction and posterior instrumentation is a viable alternative to the standard combined approach. This approach continues to evolve as instrumentation development and possesses significant advantages.
At the heart of organ donation. Case reports of organ donation after cardiac death in two patients with successfully repaired AAST grade V cardiac injuries
Authors: Paola Fugazzola, Luca Ansaloni, Marco Benni, Alessandro Circelli, Federico Coccolini, Emiliano Gamberini, Andrea Nanni, Emanuele Russo, Matteo Tomasoni, Vanni Agnoletti
Journal: World J Emerg Surg (2019)
Keywords: donation after circulatory death (dcd), extracorporeal membrane oxygenation (ecmo), heart injury, organ donation
MeSH terms: Death, Heart / physiopathology, Organ Preservation / methods, Tissue and Organ Procurement / methods, Case Reports, Adult, Female, Heart Injuries / complications, Heart Injuries / mortality, Humans, Male, Middle Aged, Tissue Donors, Wounds and Injuries / complications, Wounds and Injuries / mortality

Background:
Trauma victims could be an important source of organs. This article presents two cases of successful organ donation and transplant, after Maastricht category III cardiac death in patients with successfully repaired AAST grade V traumatic cardiac injuries.
Case presentation:
The first donor was an adult patient with self-inflicted heart stab wound and non-survivable burn injury. The second one was an adult patient with blunt cardiac and abdominal trauma and an anoxic brain injury due to a car accident. The cardiac injury was promptly repaired in both patients. In the first case, adequate organ perfusion ante-mortem was achieved thanks to venoarterial extracorporeal membrane oxygenation and intensive care unit support. The above procedure allowed successful organ donation and transplantation even after Maastricht category III cardiac death. This is the first case reported where, for organ donation purposes, it was made necessary first thing to avoid the immediate death of the patient, due to a rare and frequently not survivable cardiac injury. The challenge of preserving organ perfusion, due to major burn injury effects, was faced afterwards.
Conclusions:
The outcomes of these two cases suggest that a repaired heart injury should not be considered as an absolute contraindication to organ donation, even if it is associated with non-survivable major burns. Therefore, cardiac death could provide an opportunity for these kinds of patients to contribute to the pool of potential organ donors.
Intrauterine contraceptive device migration presenting as abdominal wall swelling: a case report
Authors: Imtiaz Wani, Adil Syed, Muddasir Maqbool, Iftikhar Bakshi, Hilal Bhat, Faheem Ul Hassan Andrabi, Naveed Mohsin
Journal: Case Rep Surg (2011)
MeSH terms: Case Reports

A number of complications are reported with the use of intrauterine contraceptive devices. These may pursue asymptomatic course or present as an acute abdomen after migration into peritoneal cavity. The authors here are reporting an abdominal wall swelling caused by transuterine migration of a copper intrauterine contraceptive device in a 28-year-old female. An open approach was used, and impacted foreign body was retrieved.
Intrarenal Adrenocortical Adenoma Treated by Robotic Partial Nephrectomy with Adrenalectomy
Authors: Samay Sappal, Jay Sulek, Steven C Smith, Lance J Hampton
Journal: J Endourol Case Rep (2016)
MeSH terms: Case Reports

Background:
We present an intrarenal adrenocortical adenoma discovered incidentally after robot-assisted partial nephrectomy and total adrenalectomy for a suspicious renal mass. Current literature describes the rare occurrence of an adrenocortical adenoma arising from a renal-adrenal fusion. This case represents an uncommon, benign pathology that should be considered in the differential diagnosis of an enhancing renal mass.
Case presentation:
The patient is a 62-year-old female found to have an enhancing mass at the anterolateral aspect of the upper pole of the right kidney concerning for renal-cell carcinoma. CT imaging was performed to work up a cause for hyperparathyroidism. During robot-assisted partial nephrectomy, the lesion was found to be partially adherent to the lateral limb of the right adrenal gland. Microscopic evaluation with Melan-A staining showed the mass to be of adrenal origin with benign features and lack of capsulation, indicating an adrenal adenoma arising from intrarenal ectopic adrenal rests.
Conclusion:
An intrarenal adrenal adenoma arising from ectopic adrenal tissue is a unique pathology that represents a benign differential diagnosis in the evaluation of an enhancing renal mass. However, it cannot be differentiated from renal-cell carcinoma based on cross-sectional imaging alone and requires postoperative pathologic assessment to confirm the diagnosis.
Treatment of Common Femoral Artery Pseudoaneurysm: A Novel Approach Utilizing a VASCADE Percutaneous Closure Device
Authors: Mark Dalvin, Brandon Dessecker, Eugene Vitvitsky
Journal: Case Rep Surg (2019)
MeSH terms: Case Reports

Iatrogenic common femoral artery pseudoaneurysm is a well-known complication to vascular access. Many options, both surgical and nonsurgical, have been implemented as means to treat pseudoaneurysms such as thrombin injection, image-guided compression, and percutaneous closure devices. This case report demonstrates a novel technique using a VASCADE closure device to successfully treat an iatrogenic common femoral pseudoaneurysm.
Liver Hydatid Cyst Masquerading as a Liver Abscess
Authors: Hezborn M Magacha, Venkata Vedantam, Neethu Vedantam, Ashwin Jagadish
Journal: Cureus (2023)
Keywords: cyst hydatid, hepatic hydatid cyst, incidental liver abscess, liver abscess aspiration, masquerading conditions
MeSH terms: Case Reports

Hydatid cyst of the liver is a rare zoonotic disease in the United States. It is caused by Echinococcus granulosus. This disease is mainly seen among immigrants from countries where this parasite is endemic. Differential diagnoses of such lesions can include pyogenic or amebic abscesses, in addition to other benign or malignant lesions. We report the case of a 47-year-old woman who presented with symptoms of abdominal pain and was diagnosed with a hydatid cyst of the liver masquerading as a liver abscess. Microscopic and parasitological tests confirmed this diagnosis. The patient was treated and discharged without further complications during follow-up.
Endosonography-guided biliary drainage with one-step placement of a newly developed fully covered metal stent followed by duodenal stenting for pancreatic head cancer
Authors: Kei Ito, Naotaka Fujita, Yutaka Noda, Go Kobayashi, Takashi Obana, Jun Horaguchi, Shinsuke Koshita, Yoshihide Kanno, Takahisa Ogawa, Yuhei Kato, Yasunobu Yamashita
Journal: Diagn Ther Endosc (2010)
MeSH terms: Case Reports

An 83-year-old man was admitted to our department, presenting with jaundice, fever, and nausea. CT revealed a pancreatic head tumor with duodenal invasion. Endoscopic transpapillary biliary drainage was unsuccessful due to stenosis at the second portion of the duodenum and tumor invasion to the papilla of Vater. Using a convex linear array echoendoscope, a fully-covered metal stent was placed across the puncture tract to bridge the duodenum and the bile duct. After improvement of jaundice, a duodenal metal stent was placed across the stricture of the duodenum. No procedure-related complications occurred. Neither migration nor obstruction of the two stents was observed during the three months followup period. Combination of ESBD using a fully covered metal stent and duodenal stenting is a feasible technique and possibly a less invasive treatment option for malignant biliary and duodenal obstruction compared to surgery.
Habit breaking appliance for multiple corrections
Authors: Reji Abraham, Geetha Kamath, Jasmeet Singh Sodhi, Sonia Sodhi, Chandki Rita, S Sai Kalyan
Journal: Case Rep Dent (2013)

Tongue thrusting and thumb sucking are the most commonly seen oral habits which act as the major etiological factors in the development of dental malocclusion. This case report describes a fixed habit correcting appliance, Hybrid Habit Correcting Appliance (HHCA), designed to eliminate these habits. This hybrid appliance is effective in less compliant patients and if desired can be used along with the fixed orthodontic appliance. Its components can act as mechanical restrainers and muscle retraining devices. It is also effective in cases with mild posterior crossbites.
Surgical treatment for thyrotoxic hypokalemic periodic paralysis: case report
Authors: Yi-Chu Lin, Che-Wei Wu, Hui-Chun Chen, Hsiu-Ya Chen, I-Cheng Lu, Cheng-Jing Tsai, Wen-Rei Kuo, Feng-Yu Chiang
Journal: World J Surg Oncol (2012)
MeSH terms: Hyperthyroidism / surgery, Hypokalemic Periodic Paralysis / surgery, Thyroidectomy, Thyrotoxicosis / surgery, Case Reports, Research Support, Non-U.S. Gov't, Adult, Humans, Hyperthyroidism / complications, Hyperthyroidism / pathology, Hypokalemic Periodic Paralysis / etiology, Hypokalemic Periodic Paralysis / pathology, Male, Middle Aged, Thyrotoxicosis / etiology, Thyrotoxicosis / pathology

Thyrotoxic hypokalemic periodic paralysis (THPP) is a rare, potentially life-threatening endocrine emergency. It is characterized by recurrent muscle weakness and hypokalemia. Because many THPP patients do not have obvious symptoms and signs of hyperthyroidism, misdiagnosis may occur. The published studies revealed that definitive therapy for THPP is control of hyperthyroidism by medical therapy, radioactive iodine or surgery, but the long-term post-operative follow-up result was not observed. We reported two cases of medically refractory THPP with recurrent paralysis of extremities and hypokalemia, and both were combined with thyroid nodules. Both patients were treated with total thyroidectomy; the pathology revealed that one is Graves' disease with thyroid papillary carcinoma, and the other is adenomatous goiter with papillary hyperplasia. No episode of periodic paralysis was noted and laboratory evaluation revealed normal potassium level during the post-operative follow up. Our experience suggests that total thyroidectomy by experienced surgeon is an appropriate and definite treatment for medically refractory THPP, especially in cases combined with thyroid nodules.
Ethics in the interface between multidisciplinary teams: a narrative in stages for inter-professional education
Authors: Katherine Wiles, Nawal Bahal, Hilary Engward, Andrew Papanikitas
Journal: London J Prim Care (Abingdon) (2016)
Keywords: ethics, education, inter-professional, multi-disciplinary, narrative

An ethically problematic clinical case is used to illustrate the potential importance of understanding clinical ethics in an interdisciplinary context. Whilst much has been written on ethics education for multidisciplinary and interdisciplinary teams, we argue that it is important that both healthcare professions and healthcare teams are able to look outside their own disciplinary ethos and sometimes outside their formal teams when considering the ramifications of an ethical issue. A complex (fictional but based on the authors' pooled experiences) case involving the delivery of a new-born from a mother with HIV is used to illustrate this, because multiple clinical teams will be involved at different times and in parallel with one another.
Liver venous deprivation for resection of advanced hilar cholangiocarcinoma-a case report and review of the literature
Authors: Radoslava Stoyanova, Helmut Kopf, Wolfgang Schima, Wolfgang Karl Matzek, Alexander Klaus
Journal: Explor Target Antitumor Ther (2022)
Keywords: hilar cholangiocarcinoma, klatskin, extended hepatectomy, future liver remnant, liver venous deprivation, portal vein embolization
MeSH terms: Case Reports

Hilar cholangiocarcinoma is a rare primary malignancy associated with a dismal prognosis. Currently, complete extended right or left-sided hepatectomy is the primary curative therapy. Achieving a negative resection margin is associated with long-term survival and better quality of life, while post-hepatectomy liver failure (PHLF) due to insufficient liver remnant remains the most dreaded complication with a negative effect on overall survival. Precise preoperative management with sufficient future remnant liver (FRL) volume is the key to achieving good results in the treatment of bile duct carcinoma. To present a case report and a literature review for preoperative FRL optimization prior to major hepatectomies for hilar cholangiocarcinoma. Improvement of postoperative outcomes after extended liver resections in the case of hilar cholangiocarcinoma. A 62-year-old Caucasian woman with Lynch syndrome presented to our department with a hilar cholangiocarcinoma Bismuth type IIIa. The patient had an insufficient future liver volume for extended liver resection. She underwent preoperative preconditioning using a liver venous deprivation (LVD) and underwent two weeks later a right trisectorectomy without any interventional complications. Liver function remained stable postoperatively. The patient was discharged on the 20th postoperative day without major surgical post-operative complications or the need for readmission. LVD is a technically feasible, safe, and effective procedure to increase the FRL in a short period of time with low intra and post-operative complications and therefore improving the survival of patients with hilar cholangiocarcinoma.
Cerebral Sinus and Venous Thrombosis Associated with von Willebrand Factor, Independently of Factor VIII
Authors: Mari Terashima, Hiroshi Kataoka, Hirosei Horikawa, Hiroyuki Nakagawa, Toshiaki Taoka, Masanori Matsumoto, Kozue Saito, Kimihiko Kichikawa, Satoshi Ueno
Journal: Clin Med Case Rep (2008)
Keywords: cerebral sinus, procoagulant factor viii, rheolytic thrombectomy, venous infarction, venous thrombosis, von willebrand factor
MeSH terms: Case Reports

Background and purpose:
Previous studies have linked procoagulant factor VIII (F VIII) to an increased risk of venous thrombosis, whereas the relation between plasma von Willebrand factor (VWF) and venous thrombosis remains poorly understood. Elevated VWF levels are frequently found in patients with cerebral sinus and venous thrombosis (CSVT), always in association with high F VIII levels. We describe a patient with CSVT accompanied by elevated VWF levels without high F VIII levels.
Case description:
A 23-year-old healthy man who had headache noticed difficulty in moving the right hand. On the following day, he lost consciousness and had partial seizures of the right hand. After regaining consciousness, weakness of the right extremities developed. The cranial angiogram confirmed occlusion of the superior sagittal sinus. The levels of VWF and F VIII were 238% and 101.9 IU/dl, respectively. We performed balloon percutaneous transluminal angioplasty and mechanical thrombectomy, leading to successful recanalization of the intracranial sinuses. VWF levels were decreased along with radiographic improvement, independently of F VIII.
Conclusion:
VWF may contribute to CSVT and that inhibition of VWF activity potentially has a role in the future treatment of pathological conditions related to venous thrombosis.