OpenMed/multicare-articles huggingface dataset:
HeartMate 3 Explantation Using Felt Plug for Ventriculotomy Occlusion
Authors: Melissa Medina, Amit Alam, Amarinder Bindra, Nishi Patel, Cesar Guerrero-Miranda, Katharina Fetten, Dan M Meyer, Aldo E Rafael-Yarihuaman
Journal: Methodist Debakey Cardiovasc J (2023)
Keywords: lvad explantation, myocardial recovery, ventriculotomy occlusion
MeSH terms: Heart Failure / diagnosis, Heart Failure / surgery, Heart-Assist Devices, Case Reports, Device Removal / methods, Humans, Myocardium, Retrospective Studies

Left ventricular assist devices (LVAD) can be utilized for heart failure patients as a bridge to transplant, bridge to destination, or bridge to recovery. Given the lack of a universally accepted consensus for assessing myocardial recovery, techniques and strategies in LVAD explantation also vary. In addition, the incidence of LVAD explantation remains relatively low, and surgical techniques of explantation continue to be areas of interest. Our approach using a felt-plug Dacron technique is an effective way to preserve left ventricular geometry and cardiac function.
Two cases of COVID-19 presenting with severe malaria: a clinical challenge (case report)
Authors: Nana Kwame Ayisi-Boateng, Kwadwo Boampong, Betty Nkansah Osei Mensah, Eric Oduro, Kingsley Badu
Journal: Pan Afr Med J (2023)
Keywords: covid-19, ghana, malaria, case report, sub-saharan africa
MeSH terms: COVID-19 / complications, COVID-19 / diagnosis, Malaria / complications, Malaria / diagnosis, Case Reports, Adolescent, Child, Female, Ghana, Humans, Public Health, SARS-CoV-2

The novel coronavirus (COVID-19) pandemic has stretched the medical resources of both developed and developing countries. The global focus on COVID-19 may lead to the neglect of other infectious diseases such as malaria which is still endemic in many African countries. Some similarities in malaria and COVID-19 disease presentations may also lead to late diagnosis of either disease which could complicate the effects. Here, we present two cases of a 6-year-old child and a 17-year-old female who presented to a primary care facility in Ghana with a clinical and microscopy-confirmed diagnosis of severe malaria complicated by thrombocytopenia. As their symptoms worsened with associated respiratory complications, nasopharyngeal samples were taken for real-time polymerase chain reaction (RT-PCR) and tested positive for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Clinicians, policymakers, and public health practitioners should be alert to the variety of presenting symptoms of COVID-19 and its similarity to malaria to mitigate the risk of mortality from either disease.
Oral Rehabilitation of Oral Cancer Patients Using Zygomatic Implant-Supported Maxillary Prostheses with Magnetic Attachment: Three Case Reports
Authors: Hisashi Ozaki, Hiromasa Sakurai, Yukie Yoshida, Hideyuki Yamanouchi, Mitsuyoshi Iino
Journal: Case Rep Dent (2018)
MeSH terms: Case Reports

Maxillectomy for malignant tumor often results in a maxillary defect and serious oral dysfunction. A prosthesis is usually provided for postoperative oral rehabilitation of such patients with maxillary defects. However, the further the resected region extends, the less stable the prosthesis becomes, due to insufficient bone and tooth support. Therefore, in many cases, conventional resection dentures may not be adequate to restore the oral function. Effective utilization of dental and zygomatic implants may help to restore oral function in patients with severe maxillary defects. This clinical report describes the management of three patients with severe maxillary defects following cancer ablative surgery who were rehabilitated using maxillary prostheses with magnetic attachments supported by dental and zygomatic implants. Occlusal reconstruction was performed with removable prostheses supported with two or four implants and magnetic attachment. The oral function was evaluated before and after prosthodontic treatment with implants using the Oral Health Impact Profile (OHIP-14) and functional chewing score. Results indicated improvement in all cases. These findings show that quality of life (QOL) and oral function were improved.
Intra-articular dislocation of patella with femoral impaction-A case report and review of literature
Authors: A Al Khalifa, K Syed
Journal: Int J Surg Case Rep (2019)
Keywords: case report, dislocation, intra-articular, patella

Introduction and case presentation:
Acute traumatic patella dislocations are common injuries seen in emergency departments. We present a rare injury which involves an acute, irreducible intra-articular dislocation of the patella. In this particular case, we describe a horizontal type intra-articular dislocation of the patella in a 66-year-old lady, which was complicated by impaction into the distal femur. She underwent two failed closed reduction attempts, but subsequently reduced spontaneously on the orthopaedic floor as she was waiting for an open reduction in the operating room.
Discussion:
The management of acute patellar dislocations can be divided into closed and open reduction methods. In cases where a closed reduction is unsuccessful, an open reduction under general anesthesia may be pertinent to treat this acute condition.
Conclusion:
We report a case of an intra-articular patella dislocation which has shown that spontaneous reduction is possible for cases following unsuccessful initial closed reduction, yet it still remains unadvisable to delay open reduction. We highlight, through this case, the importance of maintaining a high index of suspicion for these uncommon injuries.
Granulomatous gingival manifestation in Melkersson Rosenthal syndrome: a case report
Authors: Mouna Snoussi, Faten Frikha, Hela Mnif, Donia Chebbi, Sameh Marzouk, Tahya Boudawara, Zouhir Bahloul
Journal: Pan Afr Med J (2023)
Keywords: facial edema, melkersson rosenthal syndrome, case report, facial palsy, fissured tongue
MeSH terms: Bell Palsy, Gingival Hyperplasia, Melkersson-Rosenthal Syndrome / diagnosis, Case Reports, Adult, Face, Female, Gingiva, Humans

Melkersson-Rosenthal syndrome is a rare condition of unknown etiology. It is characterized by a classical triad of symptoms: relapsing facial and lip swelling, facial palsy and a fissured tongue. We report the case of a 29-year-old female patient who presented with the above-mentioned symptoms of Melkersson-Rosenthal syndrome. However, clinical examination revealed an exceptional manifestation, which is the gingival hyperplasia. The symptoms were partially managed with systemic steroids and surgical resection of gingival hyperplasia. The most significant finding to emerge from our case is that gingival enlargement can be identified as a rare clinical feature of the MRS disease, which is confirmed difficult to be managed.
Swyer-James-MacLeod syndrome with unilateral pulmonary fibrosis: a case report
Authors: Omar Abdulla, John Cain, John Howells
Journal: BJR Case Rep (2017)
MeSH terms: Case Reports

Swyer-James-MacLeod syndrome is a rare, complex disease characterized by the radiological finding of unilateral hyperlucent lung due to pulmonary oligaemia and alveolar hyperdistention as a consequence of previous obliterative bronchiolitis (bronchiolitis obliterans). Idiopathic pulmonary fibrosis is a chronic, progressive, fibrosing interstitial pneumonia of unknown cause characterized by bilateral, chronic, progressive and irreversible fibrosis limited to the lungs. We report an interesting case of Swyer-James-MacLeod syndrome affecting one lung and Idiopathic pulmonary fibrosis affecting the contralateral lung.
Recurrent isolated oculomotor nerve palsy after radiation of a mesencephalic metastasis. Case report and mini review
Authors: Olga Grabau, Jochen Leonhardi, Carl D Reimers
Journal: Front Neurol (2014)
Keywords: breast carcinoma, meningeal carcinomatosis, mesencephalic metastasis, radiation, recurrent oculomotor nerve palsy

Introduction:
Recurrent oculomotor nerve palsies are extremely rare clinical conditions.
Case report:
Here, we report on a unique case of a short-lasting recurrent unilateral incomplete external and complete internal oculomotor nerve palsy. The episodic palsies were probably caused by an ipsilateral mesencephalic metastasis of a breast carcinoma and occurred after successful brain radiation therapy.
Discussion:
While the pathogenic mechanism remains unclear, the recurrent sudden onset and disappearance of the palsies and their decreasing frequency after antiepileptic treatment suggest the occurrence of epilepsy-like brainstem seizures. A review of case reports of spontaneous reversible oculomotor nerve palsies is presented.
Anaphylactoid purpura triggered by cellulitis as a favorable prognosis: case report and literature review
Authors: Natsuko Saito-Sasaki, Yu Sawada, Shun Ohmori, Daisuke Omoto, Sanehito Haruyama, Manabu Yoshioka, Daisuke Nishio, Motonobu Nakamura
Journal: Springerplus (2016)
Keywords: anaphylactoid purpura, cellulitis, inflammation

Background:
An anaphylactoid purpura affects small capillaries in the skin and other organs. Although two cases of anaphylactoid purpura exacerbated by cellulitis have been reported in Japanese literatures, its prognosis remains still unclear. Because cellulitis exacerbates various cutaneous inflammations, it has been speculated that cellulitis might also exacerbate cutaneous inflammation, such as vasculitis.
Findings:
In this article, we report that 78-year-old woman exhibited anaphylactoid purpura, following cellulitis. We also reviewed the literature concerning about this subject.
Conclusions:
This type of anaphylactoid purpura is thought to have a favorable prognosis dependent on the treatment for cellulitis.
Primary localized cutaneous nodular amyloidosis presenting as lymphatic malformation: A case report
Authors: Xiujuan Wu, Zongfeng Zhao
Journal: Open Life Sci (2021)
Keywords: lymphatic malformation, nodular amyloidosis
MeSH terms: Case Reports

Primary skin amyloidosis is a chronic skin disease in which amyloid deposits in the normal skin tissues without involving other organs. At present, the causes and mechanisms of morbidity have not been fully elucidated. There are few clinical reports of nodular skin amyloidosis, and the domestic reports are mostly limited cases. This study reported a rare case of a 46-year-old woman with primary localized cutaneous nodular amyloidosis (PLCNA). The patient presented with features of lymphatic malformation, a plexiform nodule of small blisters. Histological examination revealed amyloid deposits involving the superficial and deep dermis with a small number of plasma cells. Further examinations did not reveal evidence of systemic involvement, indicating a PLCNA. The presentation as lymphatic malformation lesions illustrates the importance of clinical pathology. Nodular amyloidosis typically manifests as single or multiple yellow-brown nodules or plaques of a few millimeters to several centimeters. The center of the nodule sometimes shows atrophy and relaxation or forms a bullous. It is recommended to perform a pathological examination to confirm the diagnosis to distinguish it from lymphatic malformation.
Nonsyndromic bilateral multiple impacted supernumerary mandibular third molars: a rare and unusual case report
Authors: G Siva Prasad Reddy, G V Reddy, I Venkata Krishna, Shravan Kumar Regonda
Journal: Case Rep Dent (2013)

A supernumerary tooth is that which is present additionally to the normal series and can be found in any region of the dental arch. An impacted tooth is defined as the one which is embedded in the alveolus, so that its eruption is prevented, or the tooth is locked in position by bone or the adjacent teeth. The occurrence of multiple supernumerary teeth in only one patient in the absence of an associated systemic condition or syndrome is considered as a rare phenomenon. The occurrence of supernumerary teeth in the lower molar region is rare. A prevalence of less than 2% of cases occurring in this region has been estimated. Their occurrence presents a clinical problem for orthodontists and oral surgeons. The cause, frequency, complications, and surgical operation of impacted teeth are always interesting subjects for study and research. An impacted tooth can result in caries, pulp disease, periapical and periodontal disease, temporomandibular joint disorder, infection of the fascial space, root resorption of the adjacent tooth, and even oral and maxillofacial tumours. The management of impacted wisdom teeth has changed over the past 20 years from removal of nonsymptomatic third molars to simple observation. The aim of this paper is to present a rare case of bilateral multiple impacted supernumerary mandibular third molars.
Effect of extracorporeal cytokine removal on vascular barrier function in a septic shock patient
Authors: Sascha David, Kristina Thamm, Bernhard M W Schmidt, Christine S Falk, Jan T Kielstein
Journal: J Intensive Care (2017)
Keywords: cytokines, endothelial permeability, extracorporeal removal, sepsis, vascular leakage
MeSH terms: Case Reports

Background:
Sepsis and septic shock are major healthcare problems, affecting millions of individuals around the world each year. Pathophysiologically, septic multiple organ dysfunction (MOD) is a life-threatening condition caused by an overwhelming systemic inflammatory response of the host's organism to an infection. We experimentally tested if high circulating cytokine levels might increase vascular permeability-a critical hallmark of the disease-and if this phenomenon can be reversed by therapeutic cytokine removal (CytoSorb®) in an exemplary patient.
Case presentation:
A 32-year-old Caucasian female presented with septic shock and accompanying acute kidney injury (Sequential Organ Failure Assessment (SOFA) = 18) to our ICU. In spite of a broad anti-infective regimen, adequate fluid resuscitation, and high doses of inotropics and catecholamines, she remained refractory hypotensive. The extraordinary severity of septic shock suggested an immense overwhelming host response assumingly accompanied by a notable cytokine storm such as known from patients with toxic shock syndrome. Thus, a CytoSorb® filter was added to the dialysis circuit to remove excess shock-perpetuating cytokines. To analyze the endothelial phenotype in vitro before and after extracorporeal cytokine removal, we tested the septic shock patient's serum on human umbilical vein endothelial cells (HUVECs). The effect on endothelial integrity was assessed both on the morphological (fluorescent immunocytochemistry for VE-cadherin and F-actin) and functional (transendothelial electrical resistance (TER)) level that was recorded in real time with an "electric cell-substrate impedance sensing" (ECIS) system (ibidi). We found (1) severe alterations of cell-cell contacts and the cytoskeletal architecture and (2) profound functional permeability changes, the putative cellular correlate of the clinical vascular leakage syndrome. However, the endothelial barrier was protected from these profound adverse effects when HUVECs were challenged with septic shock serum that was collected after extracorporeal cytokine removal.
Conclusions:
Beneficial observations of extracorporeal cytokine removal in septic shock patients might-at least in part-be promoted via protection of vascular barrier function.
Abdominal angina in occlusive mesenteric vascular disease: a case report
Authors: Bjoern Kitzing
Journal: Cases J (2009)

Introduction:
Abdominal angina is a descriptive term for abdominal pain that can occur postprandially in patients with occlusive mesenteric vascular disease due to insufficient increase in blood flow.
Case presentation:
In this case a 60-year-old Caucasian woman with a 2 year history of abdominal angina presented to hospital for elective mesenteric revascularization surgery. Postoperative recovery was complicated by graft occlusion resulting in hepatic ischemia as well as splenic and small bowel infarction.
Conclusion:
This case highlights the importance of keeping this differential diagnosis in mind when dealing with patients who have a long history of abdominal pain and discusses some of the complications that may occur after surgical treatment.
Uterine Arteriovenous Fistula with Concomitant Pelvic Varicocele: Endovascular Embolization with Onyx-18®
Authors: Francesco Giurazza, Fabio Corvino, Andrea Paladini, Antonio Borzelli, Domenico Scognamiglio, Giulia Frauenfelder, Giuseppe Albano, Fabio Sirimarco, Raffaella Niola
Journal: Case Rep Vasc Med (2017)
MeSH terms: Case Reports

Uterine arteriovenous fistulas are rare and acquired causes of life-threatening vaginal bleeding. They usually present with intermittent menometrorrhagia in young patients in childbearing age with history of gynecological procedures on uterus. Traditional management is hysterectomy; endovascular embolization represents nowadays an alternative strategy for patients wishing to preserve fertility. Here, the endovascular approach to a 29-year-old woman affected by severe menometrorrhagia caused by a uterine arteriovenous fistula with a concomitant pelvic varicocele is reported; a bilateral uterine arteries embolization with Onyx-18 (ev3, Irvine, CA, USA) has successfully resolved the fistula with clinical success.
Case report: Efficacy analysis of radiofrequency catheter ablation combined with atrial appendage resection for atrial tachycardia originating from the atrial appendage in children
Authors: Jing Liu, Xiaoxiao Cao, Changjian Li, Xiaoyuan Feng, Dongming Sun, Yong Zhang
Journal: Front Cardiovasc Med (2022)
Keywords: atrial appendage, atrial appendage resection, atrial tachycardia, cardiology, case report, heart surgery, radiofrequency catheter ablation, tachycardia-induced cardiomyopathy
MeSH terms: Case Reports

Objective:
The aim of this study was to investigate the efficacy of radiofrequency catheter ablation (RFCA) combined with atrial appendage (AA) resection to treat atrial tachycardia (AT) originating from the AA in children.
Materials and methods:
Using the Ensite three-dimensional electroanatomic mapping system, three children with AT originating from the AA were diagnosed. Clinical features and electrocardiographic (ECG) manifestations were analyzed. Ablations were performed using a cold saline-infused catheter at appendages targeting loci of AT origin under the guidance of the Ensite system. Atrial appendage resection was performed in combination with cardiac surgery, and the curative effect was evaluated.
Results:
The ages of the three patients were 3.5, 5.75, and 12.9 years. Two cases originated from the right atrial appendage (RAA) and one originated from the left atrial appendage (LAA). The ECG characteristics of AT from the RAA were as follows: (1) negative P waves in lead V1; (2) positive P waves in leads II, III, and aVF; (3) positive P wave in lead I with varying shapes in lead aVL; and (4) prolonged PR interval with no QRS wave after some P waves. The ECG of the LAA was characterized by (1) positive P waves in lead V1 with a bimodal pattern; (2) positive P waves in leads II, III, and aVF; and (3) negative P waves in leads I and aVL. Preoperative echocardiography showed cardiac enlargement and a decreased left ventricular ejection fraction (LVEF) in all three cases. One case was cured after RFCA, and the remaining two cases required AA resection after RFCA. No recurrence was detected at 1-18 months of follow-up, and the left ventricular end-diastolic diameter and LVEF returned to normal.
Conclusion:
Atrial tachycardia originating from the AA in children showed a characteristic P-wave presentation on ECG, and sustained episodes of AT resulted in tachycardia-induced cardiomyopathy. Children who are not successfully controlled by RFCA or who have a recurrence after RFCA could benefit from AA resection.
Blastoid Variant Mantle Cell Lymphoma Expressing Aberrant CD3 and CD10 with Concurrent Small Lymphocytic Lymphoma: Establishment of a Clonal Relationship by B- and T-Cell Receptor Gene Rearrangements
Authors: Christopher L Felten, Joel A Chan, Dulce R DeCastro, Jean Lopategui, Swapnil P Rajurkar
Journal: Case Rep Hematol (2018)
MeSH terms: Case Reports

Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin B-cell lymphoma typically expressing CD19, CD20, CD5, FMC-7, CyclinD1, and SOX-11 and harboring the IgH/CCND1 translocation. We report a blastoid variant of mantle cell lymphoma (MCL) involving an inguinal lymph node that, in addition to classical phenotypic and genetic findings, also aberrantly coexpresses surface CD10 and cytoplasmic CD3. Small lymphocytic lymphoma (SLL) was also present in the same lymph node and in the bone marrow. B- and T-cell gene rearrangement studies by PCR show the MCL and SLL to be clonally related. Expression of multiple aberrant antigens and concurrent lymphomas of different classifications can cause a diagnostic challenge. Awareness of such a presentation and integration of the data from morphologic evaluation, flow cytometry, immunohistochemistry, and FISH studies is required for proper diagnosis, prognosis, and therapy.
Clinical and genetic analysis of Christianson syndrome caused by variant of SLC9A6: case report and literature review
Authors: Yan Dong, Ruofei Lian, Liang Jin, Shichao Zhao, Wenpeng Tao, Lijun Wang, Mengchun Li, Tianming Jia, Xuejing Chen, Shushi Cao
Journal: Front Neurol (2023)
Keywords: christianson syndrome, slc9a6 gene variant, epilepsy, genetics, global developmental delay, whole-exome sequencing

Background:
Intellectual disability, X-linked, syndromic, Christianson type (MRXSCH, OMIM: 300243)-known as Christianson syndrome (CS)-is characterized by microcephaly, epilepsy, ataxia, and absence of verbal language ability. CS is attributed to mutations in the solute carrier family 9 member A6 gene (SLC9A6).
Materials and methods:
This study reports the case of a boy 1 year and 3 months of age who was diagnosed with CS in our department. Genetic etiology was determined by whole-exome sequencing, and a minigene splicing assay was used to verify whether the mutation affected splicing. A literature review of CS cases was conducted and the clinical and genetic features were summarized.
Results:
The main clinical manifestations of CS include seizures, developmental regression, and exceptional facial features. Whole-exome sequencing revealed a de novo splice variant in intron 11 (c.1366 + 1G > C) of SLC9A6. The mutation produced two abnormal mRNA products (verified by a minigene splicing assay), resulting in the formation of truncated protein. A total of 95 CS cases were identified in the literature, with various symptoms, such as delayed intellectual development (95/95, 100.00%), epilepsy (87/88, 98.86%), and absent verbal language (75/83, 90.36%). At least 50 pathogenic variants of SLC9A6 have been identified, with the highest frequency observed in exon 12.
Conclusion:
Our patient is the first case with the c.1366 + 1G > C variant of SLC9A6 in CS. The summary of known cases can serve as a reference for analyzing the mutation spectrum and pathogenesis of CS.
A Recurrent Episode of Dermatomyositis Associated with Papillary Thyroid Cancer
Authors: Vijay Gopal Eranki
Journal: Case Rep Endocrinol (2017)
MeSH terms: Case Reports

Objective:
It is uncommon for dermatomyositis to be associated with papillary thyroid cancer. We report an unusual case of papillary thyroid cancer presenting with dermatomyositis.
Methods:
The case history, imaging and laboratory data is reviewed.
Results:
We report the case of a 62-year-old female with a prior history of dermatomyositis and breast cancer who presented with a recurrent episode of dermatomyositis. Extensive evaluation of the cause of the dermatomyositis recurrence revealed no recurrence of the breast cancer but a thyroid nodule was identified. The nodule was biopsied and the patient was noted to have papillary thyroid cancer. The patient subsequently underwent total thyroidectomy and had gradual improvement in her dermatomyositis.
Conclusion:
It is very uncommon for dermatomyositis to be associated with papillary thyroid cancer.