OpenMed/multicare-articles huggingface dataset:
Necrotizing Fasciitis Resulting from an Anastomotic Leak after Colorectal Resection
Authors: Anthony Nagib, Chauniqua Kiffin, Eddy H Carrillo, Andrew A Rosenthal, Rachele J Solomon, Dafney L Davare
Journal: Case Rep Surg (2018)
MeSH terms: Case Reports

One of the most feared complications in colorectal surgery is an anastomotic leak (AL) following a colorectal resection. While various recommendations have been proposed to prevent this potentially fatal complication, anastomotic leaks still occur. We present a case of an AL resulting in a complicated and fatal outcome. This case demonstrates the importance of high clinical suspicion, early recognition, and immediate management.
Isolated Congenital Absence of Lumbosacral Facet Joint
Authors: Joseph Maalouly, Dany Aouad, Hicham G Abd El Nour, Alexandre Nehme, Fouad Jabbour
Journal: Case Rep Orthop (2019)
MeSH terms: Case Reports

A congenital absence of the lumbar facet joint is a rare reported condition. This is the case of a 32-year-old male patient presenting with severe low back pain radiating to his right lower limb. Physical examination revealed no motor deficits, but right lower limb numbness was reported over dorsum aspect of the right foot. No other sensory or motor disturbances were reported or found on exam. Imaging studies, consisting of a spine MRI and spine CT scan with 3D reconstruction, revealed the absence of the right L5-S1 zygapophyseal joint. The patient was treated conservatively with resolution of his symptoms on one-month follow-up.
Case Series of Recurring Spontaneous Closure of Macular Hole
Authors: Abdelrahman M Elhusseiny, William E Smiddy, Harry W Flynn, Stephen G Schwartz
Journal: Case Rep Ophthalmol Med (2019)
MeSH terms: Case Reports

Macular hole can undergo spontaneous reopening and reclosure. This is a retrospective review of three patients who had spontaneous reopening and reclosure of previously spontaneously closed macular hole documented by optical coherence tomography. We report the first case of nivolumab-uveitis-associated macular hole formation. The authors hypothesize that cystoid macular edema (CME) might alter the integrity of foveal tissues or conversely the orientation of the macular hole edges and play a role in formation and resolution of a macular hole.
Actinobaculum schaalii: An Emerging Uropathogen?
Authors: Peyman Tavassoli, Ryan Paterson, Jennifer Grant
Journal: Case Rep Urol (2012)
MeSH terms: Case Reports

A. schaalii is a rare uropathogen. We report urosepsis with Actinobaculum schaalii detected serendipitously in blood and urine culture in a 79-year-old with urinary tract obstruction. This paper illuminates the flaws in our current system in detecting A. schaalii and raises awareness among clinicians and laboratory teams.
Intrapericardial giant lipoma displacing the heart
Authors: C M Steger
Journal: ISRN Cardiol (2011)
MeSH terms: Case Reports

Despite their benign character, intrapericardial lipomas can cause life-threatening complications by rapid growth. This paper presents a case of an intrapericardial lipoma in an almost asymptomatic 41-year-old female patient only suffering from mild dyspnoea on exertion. The tumour was found incidentally by chest X-ray. Echocardiographic examination and a CT scan of the thorax revealed a 16 × 14 × 12 cm lipomatous tumour mass highly suspective of a lipoma. Histological examination of excised tumour specimens confirmed the diagnosis of a lipoma. The patient is currently asymptomatic and has not presented with evidence of recurrence at the 6-month followup.
Calcitriol-Mediated Hypercalcemia, Somatostatin Receptors Expression and 25-Hydroxyvitamin D3-1α- Hydroxylase in GIST Tumors
Authors: Yiraldine Herrera-Martínez, María José Contreras González, Sergio Pedraza-Arévalo, Maria Del Carmen Guerrero Martínez, Ángela Rodrigo Martínez, Alberto González Menchen, Maria Angeles Blanco Molina, Maria Angeles Gálvez-Moreno, Alberto L Moreno-Vega, Raúl M Luque, Aura D Herrera-Martínez
Journal: Front Endocrinol (Lausanne) (2022)
Keywords: gist tumor, calcitriol, corticoids, hypercalcemia, somatostatin receptors
MeSH terms: Gastrointestinal Stromal Tumors / drug therapy, Hypercalcemia / genetics, Case Reports, Research Support, Non-U.S. Gov't, Review, Calcifediol, Calcitriol / therapeutic use, Female, Humans, Mixed Function Oxygenases, Receptors, Somatostatin, Vitamin D / analogs & derivatives, Receptors, Somatostatin, Vitamin D, 25-hydroxyvitamin D, Mixed Function Oxygenases, Calcitriol, Calcifediol

Hypercalcemia is a common complication in cancer patients Mainly caused by Parathyroid hormone-related protein (PTHrP) secretion and metastasis. Calcitriol secretion is a rare source of hypercalcemia in solid tumors, especially in gastrointestinal stromal tumors (GIST). We present a case report of a female patient with a 23 cm gastric GIST that expressed somatostatin-receptors and presented with severe hypercalcemia due to calcitriol secretion. Calcium control was achieved with medical treatment before the use of targeted-directed therapies. Surgery was performed and allowed complete tumor resection. Two years later, patient remains free of disease. Molecular analysis revealed the mRNA expression of 25-hydroxyvitamin D3-1-hydroxylase (1αOHase) and vitamin-D receptors in the tumor cells, confirming the calcitriol-mediated mechanism. Furthermore, the expression of the endotoxin recognition factors CD14 and TLR4 suggests an inflammatory mediated mechanism. Finally, the expression of somatostatin-receptors, especially SST2 might have been related with clinical evolution and prognosis in this patient.
Primary Cutaneous CD4-Positive Small/Medium-Sized Pleomorphic T-Cell Lymphoma Following Heart Transplantation
Authors: B Shakerian, N Razavi, M H Mandegar
Journal: Int J Organ Transplant Med (2017)
Keywords: cd4-positive t-lymphocytes, heart transplantation, lymphoma, lymphoproliferative disorders, t-cell, cutaneous
MeSH terms: Case Reports

Post-transplantation cutaneous lymphoproliferative diseases (PTCLD) are rare, with 29 cases have so far been reported in the literature-only 4 cases underwent cardiac transplantation. Herein, we report on, to the best of our knowledge, the first case in the English literature of primary cutaneous CD4-positive small/medium-sized pleomorphic T-cell lymphoma in a cardiac transplant recipient.
Carbon Dioxide Embolism During Transanal Total Mesorectal Excision: Case Report and Literature Review
Authors: Youzhuang Zhu, Weiwei Wang, Dingsheng Liu, Hong Zhang, Lina Chen, Zhichao Li, Shangyuan Qin, Yihan Kang, Jun Chai
Journal: Front Surg (2022)
Keywords: carbon dioxide embolism, case report, etiology, prevention, transanal total mesorectal excision
MeSH terms: Case Reports

The actual incidence of carbon dioxide embolism during transanal total mesorectal excision (taTME) is unknown, but the reported incidence in the existing literature is reassuring. However, the incidence of CO2 embolism, which can be life-threatening, is severely underestimated. By reviewing the available data on carbon dioxide embolism during taTME and synthesizing other reports on CO2 embolism in laparoscopic procedures, we provide the first comprehensive account of the etiology, pathophysiology, and recommend tools to monitor carbon dioxide embolism during taTME. Additionally, we provide guidance and recommendations on preventive and therapeutic measures to minimize the adverse consequences of this potentially severe complication, knowledge about which we hope will improve patients' safety.
Bilateral vallecular cysts as a cause of Dysphagia: case report and literature review
Authors: Jonathan J Romak, Steven M Olsen, Cody A Koch, Dale C Ekbom
Journal: Int J Otolaryngol (2010)
MeSH terms: Case Reports

Cysts of the vallecula are rare, accounting for 10.5% to 20.1% of all laryngeal cysts. Vallecular cysts may present with diverse symptoms affecting the voice, airway, and swallowing. We describe the evaluation and treatment of a 70-year-old woman who presented with dysphagia caused by large bilateral vallecular cysts.
Neurolymphomatosis mimicking neurosarcoidosis: a case report
Authors: Ernestina Santos, Neil J Scolding
Journal: J Med Case Rep (2010)

Introduction:
Both neurosarcoidosis and central nervous system lymphoma can be very difficult to diagnose. We describe the case of a patient in whom neurosarcoidosis was strongly suspected, but who was eventually found to have lymphoma. We believe the case to be of interest and practical value to neurologists, oncologists and internists with an interest in inflammatory diseases.
Case presentation:
A diagnosis of neurosarcoidosis was considered in a 49-year-old Caucasian man on the basis of the following symptoms and indications: a cough, bilateral hilar lymphadenopathy confirmed by thoracic computed tomography, the development of an S1 radiculopathy, cerebrospinal fluid abnormalities (raised protein level), bilateral lung hilar and lachrymal gland uptake on a gallium scan, and erythema nodosum confirmed with skin biopsy. These were followed by the development of multiple cranial neuropathies, including seventh nerve palsy. Exhaustive further investigations yielded no evidence for an alternative diagnosis. Treatments with steroids, cyclophosphamide, intravenous immunoglobulin and finally infliximab were of no benefit. He eventually developed cutaneous nodules, a biopsy of which revealed lymphoma that proved resistant to therapy.
Conclusion:
Constant diagnostic vigilance is required in disorders such as neurosarcoidosis.
Avoiding misdiagnosis in patients with dyspnea and wheezing: a case report illustrating the clinical implications of fixation error
Authors: Fabiano Di Marco, Giuseppe Francesco Sferrazza Papa, Dejan Radovanovic, Pierachille Santus
Journal: Clin Mol Allergy (2017)
Keywords: asthma, dyspnea, fluticasone/formoterol, pulmonary function tests, tracheal stenosis
MeSH terms: Case Reports

Background:
Bronchial asthma is a heterogeneous respiratory condition which can be mimicked by a wide range of pathologies including upper airways stenosis. The accurate diagnosis of asthma, as with other conditions, may be influenced by fixation errors, which are common in medicine and occur when a physician concentrates on only one element of a clinical case without considering other relevant aspects. Here we report a challenging case characterized by the contemporaneous presence of a common disease, asthma, together with a rare respiratory disease, idiopathic tracheal stenosis.
Case presentation:
The 56-year-old female patient, a former smoker, was referred to our outpatient clinic for exertional dyspnea and persistent wheezing. There were no other respiratory or systemic symptoms over the past three months, and a psychological component was suspected. Spirometry with flow-volume evaluation and bronchoscopy were the key elements to establish the diagnoses and provide treatments. Once the diagnosis of asthma was confirmed, the combination of the anti-inflammatory corticosteroid fluticasone and the rapid-acting bronchodilator formoterol in a single inhaler effectively controlled the patient's symptoms, confirming the favorable efficacy and safety profile which are reflected in the recommendations of the international guidelines.
Conclusions:
In this paper we describe the clinical investigations and interventions that eventually confirmed a diagnosis of asthma complicated by an idiopathic tracheal stenosis and led to effective treatment of the patient. Awareness of fixation error may avoid misdiagnosis in patients with respiratory disease and a complicated history at presentation.
Having Difficult Conversations: The Advanced Practitioner's Role
Authors: Therese Svarovsky
Journal: J Adv Pract Oncol (2013)
MeSH terms: Review

Throughout the course of their disease, patients with cancer and their families look to the oncology advanced practitioner (AP) for support and guidance as they struggle with the emotional impact of a life-limiting illness, complex treatment decisions, and the challenge of sustaining hope while maintaining realistic goals. At various points along the disease trajectory, difficult conversations between the AP and the patient are essential. In this case report of a 43-year-old woman with metastatic breast cancer, we model the use of various strategies available for the AP to help make these difficult conversations as productive, relevant, and emotionally safe for the patient as possible.
On frogs, toxins and true friendship: an atypical case report
Authors: Cláudio Tadeu Daniel-Ribeiro, Christian Roussilhon
Journal: J Venom Anim Toxins Incl Trop Dis (2016)
Keywords: dart frogs, dendrobatidae, french guiana, toxins
MeSH terms: Case Reports

The authors report a series of events including the scientific interest for poisonous dendrobates of French Guiana, the human confrontation with the immensity of the evergreen rainforest, the fragility of the best-prepared individuals to a rough life, and the unique and very special manifestation of a solid friendship between two experts and enthusiasts of outdoor life. In the evergreen forest of South America, as in many other scientific field expeditions, everything may suddenly go wrong, and nothing can prepare researchers to accidents that may occur in a succession of uncontrollable errors once the first mistake is done. This is what happened during an expedition in search for dendrobates by an experienced forest guide and naturalist. The authors decided to report the story, considering that it deserved to be brought to the attention of those interested in venomous animals and toxins, in order to illustrate the potential danger of dealing with these organisms.
Giant viable hydatid cyst of the lung revealed by hiccups
Authors: Bouchentouf Rachid, Benjelloun Amine, Chafik Aziz, Aitbenasser Moulay Ali
Journal: Pan Afr Med J (2012)
Keywords: hiccups, giant hydatid cyst, lung, surgery
MeSH terms: Echinococcosis, Pulmonary / diagnosis, Hiccup / diagnosis, Case Reports, Adolescent, Diagnosis, Differential, Dyspnea / diagnosis, Dyspnea / etiology, Echinococcosis, Pulmonary / complications, Echinococcosis, Pulmonary / physiopathology, Female, Hiccup / etiology, Humans, Organ Size

Hydatid cystic disease is still a significant clinical problem in endemic countries. Hydatid cysts are usually located in the liver and lung. The resulting large cysts in the lung are a special clinical entity called giant hydatid cysts. We present a case of this rare entity: An 18-year-old woman presented with three month history of hiccups and progressive dyspnea. Chest X-ray revealed a very large homogenous opacity of the left lung. A diagnosis of giant hydatid cyst was made intra operatively; the patient was treated surgically using cystotomy and capitonnage without post-operative complications. This report illustrates that the hydatid cyst of the lung may occasionally present with signs of mediastinal compression.
Intervention to severe lower trachea obstruction supported by extracorporeal membrane oxygenation in a human immunodeficiency virus patient: A case report and literature review
Authors: Xiaolin Zhang, Lei Pan, Lei Wang, Li Q Li, Peng Zhang, Hai C Tang, Qing G Wu, Feng Li
Journal: Front Med (Lausanne) (2022)
Keywords: hiv, extracorporeal membrane oxygenation, interventional operation, trachea intubation, trachea obstruction
MeSH terms: Case Reports

Here we reported a case, male, 33 years old, diagnosed with human immunodeficiency virus (HIV) infection 5 months ago, but he didn't take antiretroviral drugs regularly. He was admitted to intensive care unit emergently due to hypoxemia, hypercapnia, and hypotension. CT showed severe lower trachea obstruction caused by soft tissue. After rapid bedside assessment, the patient was considered to need endotracheal operation, but he couldn't tolerate intubation and mechanical ventilation. Extracorporeal membrane oxygenation (ECMO) was used. Hemodynamics improved significantly along with rehydration and low-dose vasoactive drugs. Subsequently, the patient underwent rigid bronchoscopy, airway tumor resection and Y-type silicone stent implantation. Postoperatively protective endotracheal intubation and mechanical ventilation was followed. ECMO was weaned off after the operation, and endotracheal cannula was removed 6 h later. The pathological examination of excisional tissue showed lung squamous cell carcinoma. Finally, the patient was discharged safely and went to local hospital for further treatment. From this case, we conclude that ECMO could play a key role for those who need endotracheal surgery while cannot endure conventional intubation and mechanical ventilation.
Missing Inferior Vena Cava on POCUS: A Case of Left-Sided IVC with Azygos Continuation
Authors: Ankit Mehta, Kreegan Reierson, Benji Mathews
Journal: POCUS J (2023)
Keywords: diagnostic pitfalls, inferior vena cava, pocus
MeSH terms: Case Reports

The merits of utilizing point of care ultrasound (POCUS) in acutely ill patients is leading to a widespread embrace. Assessment of IVC via POCUS as part of a comprehensive multi-organ approach can help guide volume tolerance. Anatomical/developmental variations of IVC can vary widely in prevalence. As the use of POCUS expands as a diagnostic modality, it is prudent for frontline POCUS users to be cognizant of the IVC anomalies. We present a case of left sided IVC with azygous continuation discovered with POCUS that was performed to assess the volume status of the patient. This case illustrates that the awareness of different anomalies of the IVC is necessary for POCUS users to prevent misinterpretation of aberrant vessels and avoid diagnostic pitfalls.
Case Report: Infectious prophylaxis in hematological malignancies
Authors: Mauro Passucci, Chiara Masucci, Francesca Paoletti, Claudia Ielo, Alessandro Costa, Ida Carmosino, Emilia Scalzulli, Maurizio Martelli, Giuseppe Gentile, Massimo Breccia
Journal: Front Oncol (2023)
Keywords: hbv reactivation, myelofibrosis, prophylaxis, ruxolitinib, tenofovir
MeSH terms: Case Reports

Patients with hematological malignancies and past serological evidence of hepatitis B are at risk for HBV reactivation. In myeloproliferative neoplasms, continuous treatment with the JAK 1/2 inhibitor ruxolitinib confers a moderate risk of reactivation (1-10%); nevertheless, no prospective randomized data are available to strongly recommend HBV prophylaxis in these patients. Here, we report a case of primary myelofibrosis and past serological evidence of HBV infection, treated with ruxolitinib and concomitant lamivudine, developing HBV reactivation due to premature withdrawal of prophylaxis. This case underlines the potential need for persistent HBV prophylaxis in the setting of ruxolitinib treatment.
Bilateral vertical gaze palsy due to midbrain infarct associated with iron deficiency anemia in a young boy
Authors: Virna M Shah, Ratnesh Ranjan, Mrunmayi Jeste, Peter MacIntosh, Duraiswamy Ashwath
Journal: GMS Ophthalmol Cases (2020)
Keywords: iron-deficiency anemia, midbrain infarction, vertical gaze palsy
MeSH terms: Case Reports

An 8-year-old boy presented with complaints of sudden-onset binocular vertical diplopia of one day duration. Ophthalmic examination showed restricted up- and downgaze movement with rotatory nystagmus. Systemic investigations revealed iron-deficiency anemia and localized acute infarct in the left paramedian rostral and dorsal part of the upper midbrain at the level of the red nucleus on magnetic resonance imaging. The patient was started on oral iron supplement, which resulted in symptomatic as well as clinical improvement after 2 weeks.
Two cases of mimics of bone metastasis in breast cancer
Authors: Aung Win Tin, John Hardman, Geoffrey Naisby
Journal: BJR Case Rep (2017)
MeSH terms: Case Reports

In patients with breast cancer, the appearance of sclerotic bone lesions on imaging should raise the suspicion of skeletal metastases. However, before making the diagnosis it is important to consider the clinical context and remember that there are conditions that can mimic bone metastasis. We present two cases of mimics of bone metastasis: systemic mastocytosis and osteopoikilosis. These cases demonstrate clinical and radiological characteristics that would make a diagnosis of bone metastasis less likely, and highlight the need for an awareness of mimics of bone metastasis.
A Case of Resection of Hepatocellular Carcinoma in a Patient With Fontan-Associated Liver Disease
Authors: Satoshi Tokuda, Hideyuki Kanemoto, Akihiko Takagi, Yuichi Masui, Noriyuki Oba
Journal: Cureus (2023)
Keywords: cvp, fald, fontan procedure, hepatectomy, hepatocellular carcinoma
MeSH terms: Case Reports

The Fontan procedure (FP) is an operation used in patients with congenital single ventricle disease. The long-term prognosis after surgery has improved due to technological advances. However, the hemodynamics after FP are complicated. There are some reports of Fontan-associated liver disease (FALD) after FP. We report a case of a young woman who developed hepatocellular carcinoma due to FALD.
Case report: Relapsed/refractory extranodal natural killer/T-cell lymphoma nasal type with extensive central nervous system involvement
Authors: Austėja Dapkevičiūtė-Purlienė, Vytautas Augustinavičius, Andrius Žučenka
Journal: Pathol Oncol Res (2023)
Keywords: nk-cell, t-cell, case report, central nervous system, lymphoma
MeSH terms: Epstein-Barr Virus Infections / complications, Lymphoma, Lymphoma, T-Cell / complications, Case Reports, Adult, Antineoplastic Combined Chemotherapy Protocols / therapeutic use, Central Nervous System, Cytarabine / therapeutic use, Herpesvirus 4, Human, Humans, Killer Cells, Natural, Young Adult, Cytarabine

Background: Extranodal natural killer/T-cell lymphoma (ENKL) is a rare subtype of mature T and natural killer cell lymphomas associated with Epstein-Barr virus. Case: A 20-year-old presented with severe neurological symptoms and was diagnosed with stage IV ENKL, nasal type, with CNS involvement. Overall, the patient received nine treatment lines, including chemotherapy, craniospinal irradiation, allogeneic stem cell transplant (alloSCT), donor lymphocyte infusions, and novel agents (Nivolumab, Daratumumab, Thalidomide, Lenalidomide, virus-specific T cells) combined with intrathecal chemotherapy. The treatment effect was evaluated in both blood and CSF (cerebrospinal fluid). First-line SMILE chemotherapy resulted in systemic and CNS remission. Later Cytarabine-based chemotherapy and Daratumumab combination helped to reinduce remission before alloSCT. Conclusion: We show that efficacy monitoring should include both blood and CSF analysis. High-dose Cytarabine-based chemotherapy in combination with Daratumumab and intrathecal chemotherapy may be considered as salvage CNS-directed therapies. We add to existing limited data that Daratumumab penetrates the blood-brain barrier.
Hemophagocytic Lymphohistiocytosis (HLH) in a Patient with Disseminated Histoplasmosis
Authors: Neeraja Swaminathan, Jorge M Vinicius, Jesse Serrins
Journal: Case Rep Hematol (2020)
MeSH terms: Case Reports

Hemophagocytic lymphohistiocytosis (HLH) is a rare condition characterized by an overwhelming inflammatory cascade activation which is often associated with rapid progression and high mortality. It may be familial with an underlying genetic mutation or triggered by infection, malignancy, and autoimmune disease. Disseminated histoplasmosis caused by histoplasma capsulatum is a granulomatous fungal disease seen typically in immunocompromised patients with varied clinical manifestations and requires long-term antifungal therapy. We present the case of a 61-year-old immunocompromised female with significant travel history who came with fever, pancytopenia, and liver failure raising suspicion for HLH that prompted a bone marrow biopsy procedure. Hemophagocytic figures consistent with HLH and numerous encapsulated fungi resembling histoplasma were visualized. She was treated with intravenous (IV) liposomal amphotericin B. Etoposide chemotherapy and interleukin-1 (IL-1) antagonist anakinra were deferred in order to limit her immunosuppression, and treatment was focused on antifungal therapy.