OpenMed/multicare-articles huggingface dataset:
Unusual Localisation for Onychomatricoma on the 5th Toenail: A Case Report and Review of the Literature
Authors: A Coutellier, I Théate, O Vanhooteghem
Journal: Case Rep Dermatol Med (2016)

Onychomatricoma is a rare and benign tumour of the nail matrix but originates rarely from the ventral portion of the proximal nail fold. This tumour is characterised by fingerlike projections that invade the nail plate. This lesion, of unknown aetiology, is typically asymptomatic with slow progression. Localisation on the finger is the most frequently described. We report the case of a 68-year-old woman who has an onychomatricoma in an unusual location, the fifth toe of the left foot. Due to its clinical appearance, the tumour can be confused with and treated as onychomycosis. However, if it is resistant to an oral antifungal well behaved treatment, one must consider onychomatricoma diagnosis.
Mucormycotic osteomyelitis of maxilla post-COVID patient: a case report
Authors: Deeplata Mendhe, Pratibha Wankhede, Mayur Wanjari, Sagar Alwadkar
Journal: Pan Afr Med J (2021)
Keywords: fungal osteomyelitis, case report, diabetes mellitus, paranasal sinuses, seldom
MeSH terms: COVID-19 / complications, Maxillary Diseases / diagnosis, Mucormycosis / diagnosis, Osteomyelitis / diagnosis, Case Reports, Adult, Diabetes Mellitus / physiopathology, Humans, Male, Maxillary Diseases / microbiology, Maxillary Diseases / pathology, Mucormycosis / pathology, Opportunistic Infections / diagnosis, Opportunistic Infections / microbiology, Opportunistic Infections / pathology, Osteomyelitis / microbiology, Osteomyelitis / pathology

Fungal osteomyelitis is a life-threatening and seldom seen opportunistic infection. It is commonly an affectation of the nose and paranasal sinuses within the orofacial region. It is an aggressive infection that needs to be addressed promptly to prevent fatal consequences. The mode of infection is via the inhalation route and infection begins initially in the nose and paranasal sinuses with subsequent invasion into the vascular tissue, eventually leading to thrombosis and necrosis of nearby hard and soft tissues. Here, we report a case of a 31-year-old male who presented with pain over the upper jaw that was sudden in onset, continuous, dull aching, radiating towards forehead and neck of the left side, aggravates on mastication and relives on its own. He had a history of uncontrolled diabetes mellitus. On further investigation, using diagnostic and Interventional aids, a final diagnosis of mucormycotic osteomyelitis of the maxilla was made.
Case Report: No Response to Liposomal Daunorubicin in a Patient with Drug-Resistant HIV-Associated Visceral Leishmaniasis
Authors: Nicholas J Gow, Robert N Davidson, Rob Ticehurst, Andrew Burns, Mark G Thomas
Journal: PLoS Negl Trop Dis (2015)
MeSH terms: Antiprotozoal Agents / administration & dosage, Coinfection / drug therapy, Daunorubicin / administration & dosage, Drug Resistance, HIV Infections / drug therapy, Leishmaniasis, Visceral / drug therapy, Case Reports, Anti-HIV Agents / administration & dosage, HIV-1 / physiology, Humans, Leishmania donovani / physiology, Male, Middle Aged, Treatment Failure, Anti-HIV Agents, Antiprotozoal Agents, Daunorubicin

Visceral leishmaniasis (VL) in patients with HIV co-infection presents a significant therapeutic challenge due to the lessened chance of achieving long-term cure. We report a case of VL in a 60-year-old man with HIV infection who became refractory to anti-leishmania treatment due to multi-drug resistance. In the face of a worsening clinical situation, and with no other options available, he was treated with an experimental regimen of liposomal daunorubicin, which has previously been shown to have in vitro activity against Leishmania donovani and to be effective treatment of VL in animal studies. To our knowledge, he was the first patient with VL and HIV co-infection to have this treatment evaluated. We report on the lack of response to this treatment and possible causes for its failure.
Case Report: Esophageal Bronchus in a Neonate, With Image, Histological, and Molecular Analysis
Authors: Stephen L Trisno, Nara S Higano, Dan Kechele, Talia Nasr, Wendy Chung, Aaron M Zorn, Jason C Woods, James M Wells, Paul S Kingma
Journal: Front Pediatr (2021)
Keywords: mri, esophagus, fistula, foregut malformation, trachea
MeSH terms: Case Reports

In this case report, we describe the clinical course of a neonate who presented initially with respiratory distress and later with choking during feeding. He was subsequently found to have an esophageal bronchus to the right upper lung lobe, a rare communicating bronchopulmonary foregut malformation. Histological and molecular analysis of the fistula and distal tissues revealed that the proximal epithelium from the esophageal bronchus has characteristics of both esophageal and respiratory epithelia. Using whole exome sequencing of the patient's and parent's DNA, we identified gene variants that are predicted to impact protein function and thus could potentially contribute to the phenotype. These will be the subject of future functional analysis.
Osteonecrosis of the jaw in an AIDS patient: a case report
Authors: Yusuke Zushi, Kazuma Noguchi, Kuniyasu Moridera, Kazuki Takaoka, Hiromitsu Kishimoto
Journal: AIDS Res Ther (2015)
Keywords: aids, haart, osteonecrosis of the jaw

We report a rare case of osteonecrosis of the jaw following necrotizing gingivitis in a Japanese AIDS patient. Intraoral examination showed exposed necrotic bone in the left mandible and spontaneous loss of teeth. This patient was successfully treated with highly active anti-retroviral therapy combined with minimally invasive surgical procedures to remove the osteonecrosis of the jaw.
Methotrexate-related lymphoproliferative disorder of the stomach in a patient with rheumatoid arthritis: a case of disease regression after methotrexate cessation
Authors: Kazuki Ikeda, Takefumi Nakamura, Takahiro Kinoshita, Mikio Fujiwara, Suguru Uose, Hitoshi Someda, Takashi Miyoshi, Katsuhiro Io, Ken-Ichi Nagai
Journal: Clin J Gastroenterol (2016)
Keywords: lymphoproliferative disorder (lpd), methotrexate (mtx), rheumatoid arthritis (ra), stomach
MeSH terms: Antirheumatic Agents / adverse effects, Arthritis, Rheumatoid / drug therapy, Lymphoproliferative Disorders / chemically induced, Methotrexate / adverse effects, Case Reports, Aged, Antirheumatic Agents / therapeutic use, Female, Humans, Lymphoma, Large B-Cell, Diffuse / chemically induced, Lymphoma, Large B-Cell, Diffuse / diagnosis, Lymphoproliferative Disorders / diagnosis, Methotrexate / therapeutic use, Multimodal Imaging, Neoplasm Regression, Spontaneous / pathology, Positron-Emission Tomography, Stomach Neoplasms / chemically induced, Stomach Neoplasms / diagnosis, Tomography, X-Ray Computed, Antirheumatic Agents, Methotrexate

We report the case of a 78-year-old woman with methotrexate-related gastric lymphoproliferative disorder (LPD). The patient had a history of rheumatoid arthritis (RA) and had been treated with methotrexate (MTX). Endoscopic examination revealed round elevated lesions in the stomach, and a biopsy specimen showed atypical lymphoid cell proliferation. Immunohistological study found these atypical cells to be positive for L-26 but not for CD3 or EBER. Therefore, we made a diagnosis of MTX-related LPD showing features of diffuse large B-cell lymphoma. Combined positron emission tomography-computed tomography (PET-CT) using 18F-fluorodeoxyglucose (FDG) showed increased avidity in the stomach in addition to slightly increased FDG-avidity in the mediastinum and left chest wall. We decided not to start chemotherapy but to discontinue administration of MTX, with follow-up using endoscopy and PET-CT. The endoscopic examinations after cessation of MTX demonstrated gradual regression of the elevated lesions. PET-CT 6 months after cessation showed no increased FDG avidity in the stomach. While disease regression was observed in the stomach, the other FDG-avid spots remained unchanged on PET-CT. Therefore, we performed chemotherapy as additional therapy. On PET-CT after chemotherapy, the FDG-avid spots remained unchanged for more than 1 year, and we eventually concluded that they were RA-related inflammatory lesions. In patients with MTX-related LPD, cessation of MTX may be a therapeutic option, but careful follow-up and chemotherapy in accordance with the clinical course are essential.
Idiopathic infantile arterial calcification: a possible cause of refractory cardiopulmonary failure in infancy
Authors: A Nael, P J Siaghani, D Chen, S G Romansky, L Shane
Journal: Case Rep Pathol (2014)

Idiopathic Infantile Arterial Calcification is a rare autosome recessive disease characterized by extensive calcification of medium and large arteries. Loss-of-function mutations in ectonucleotide pyrophosphatase/phosphodiesterase 1 gene have been described in more than 80% of the cases. Although the diagnosis is usually made at autopsy, it is possible to identify cases based on clinical presentation, radiology findings, and molecular studies. Appropriate treatment can be initiated and has been shown to successfully induce permanent remission. We report a 4-week-old neonate who initially presented with respiratory distress, heart failure, and Coxsackie B viremia suggestive of viral induced cardiomyopathy. His symptoms progressed to multiple organ failure and he eventually expired at four weeks of age. On autopsy, diffuse calcium deposition within the internal elastic lamina of medium and large arteries was identified, as well as narrowing of lumen due to myointimal proliferation. This case report will emphasize the importance of taking this rare curable disease into consideration in all cases of infants with cardiopulmonary failure.
Case report: Traumatic lumbosacral spondyloptosis with locked L5 inferior articular process
Authors: Tao Tang, Yuchi Liu, Jian Cao, Tianlong Wu, Dingwen He, Xigao Cheng, Shuihua Xie
Journal: Front Surg (2023)
Keywords: case report, lumbosacral dislocation, posterior lumbar fusion, reduction, traumatic lumbosacral spondyloptosis
MeSH terms: Case Reports

Background:
Traumatic lumbosacral spondyloptosis is a very rare spinal disease caused by high-energy trauma. We report a case of traumatic lumbosacral spondyloptosis with locked L5 inferior articular process.
Case presentation:
A 33-year-old man presented with multisite pain for 6 h following waist trauma and was admitted to the hospital. He suffered multiple injuries from severe impact on the waist after driving an out of control forklift truck. Preoperative imaging examinations revealed that the patient was diagnosed with traumatic lumbosacral spondyloptosis and the L5 inferior articular process was locked into the anterior margin of the S1 vertebra. A posterior instrumentation, decompression of the cauda equina, and interbody fusion procedure was performed. The patient received hyperbaric oxygen and rehabilitation treatment 10 days after the surgery. At the 6-month postoperative follow-up, the muscle strength of the lower limbs was improved, the patient had no numbness of both lower limbs, and the urinary retention symptom was significantly improved. The American Spinal Injury Association grade improved from grade C preoperatively to grade D postoperatively. As far as we know, there have been no relevant reports on traumatic lumbosacral spondyloptosis with locked L5 inferior articular process yet.
Conclusion:
We believe that the hyperflexion and shear forces were the potential causes of this injury. In addition, the preoperative imaging examinations should be evaluated carefully. If the inferior articular process of L5 were locked, we suggest removing the bilateral inferior articular processes first and then perform reduction.
Ossifying fibromyxoid tumor of the oral cavity: rare case report and long-term follow-up
Authors: Maria Eduarda Pérez-de-Oliveira, Thayná Melo de Lima Morais, Márcio Ajudarte Lopes, Oslei Paes de Almeida, Willie F P van Heerden, Pablo Agustin Vargas
Journal: Autops Case Rep (2020)
Keywords: head and neck neoplasms, mouth, soft tissue neoplasms
MeSH terms: Case Reports

Ossifying fibromyxoid tumor (OFMT) is a rare mesenchymal soft tissue benign neoplasm with an uncertain line of differentiation, which arises most frequently in extremities. The head and neck region involvement is uncommon, with only ten intraoral cases published in the English-language literature. One additional case of OFMT is reported here, including a literature review of intraoral reported cases. A 45-year-old female patient presented a painless nodule involving the buccal mucosa of approximately two years duration, measuring nearly 1.3 cm in maximum diameter. The main histopathological features include ovoid to round cells embedded in a fibromyxoid matrix with a perpheral shell of lamellar bone. Immunohistochemically, the tumor showed immunoreactivity for vimentin and S100. No recurrence has been detected after 7 years of follow-up.
Interdisciplinary Management of Gingivitis Artefacta Major: A Case Series
Authors: Naina Pattnaik, Anurag Satpathy, Rinkee Mohanty, Rashmita Nayak, Surjeet Sahoo
Journal: Case Rep Dent (2015)

Cases described here discuss interdisciplinary (periodontal and behavioral) approach in the management of rare and difficult to diagnose self-inflicted injuries of gingiva such as gingivitis artefacta major. Self-inflicted injuries to the gingiva are rare and their management by periodontal therapy alone is inadequate. Proper management of this condition requires early detection and effective psychological treatment through behavioral therapy in addition to the treatment of dental lesion. Three male patients in their twenties presented with traumatic injuries of gingiva with history of self-injury and underlying emotional disturbances. Following basic periodontal intervention, their self-inflicting behavior was confirmed on psychiatric consultation. All of them underwent cognitive behavior therapy and were able to successfully curb their self-inflicting behavior prior to any definitive dental procedures. These cases illustrate the essentiality of behavioral intervention in addition to periodontal procedures in the management of such lesions.
Laparoscopic Cholecystectomy in a Patient With Situs Inversus Totalis Presenting With Cholelithiasis: A Case Report
Authors: Tao He, Jieyu Zou, Haiyu Song, Bin Yi, Ke Sun, Juan Yang, Tingting Lei, Lin Xu, Guangkuo Li
Journal: Front Surg (2022)
Keywords: case report, cholecystectomy, cholelithiasis, laparoscope, situs inversus
MeSH terms: Case Reports

Laparoscopic cholecystectomy is the standard treatment for cholelithiasis. A very rare condition named situs inversus should not be considered as a contraindication for laparoscopic cholecystectomy. Here, we reported a case of successful laparoscopic cholecystectomy in a patient with situs inversus totalis. We also described the technical advantages of this treatment and reviewed the literature.
Recurrent Episodes of Diffuse Alveolar Hemorrhage in Systemic Sclerosis 30 Days Apart
Authors: Hussien Saab, Tushar Bajaj, Kirandeep Bains, Ralph Garcia-Pacheco
Journal: J Investig Med High Impact Case Rep (2019)
Keywords: critical care, diffuse alveolar hemorrhage, education, hemorrhage, pulmonary, systemic sclerosis
MeSH terms: Hemorrhage / etiology, Lung Diseases / etiology, Pulmonary Alveoli / blood supply, Scleroderma, Systemic / complications, Case Reports, Bronchoalveolar Lavage Fluid / cytology, Bronchoscopy, Female, Hemorrhage / pathology, Humans, Lung Diseases / drug therapy, Lung Diseases / pathology, Methylprednisolone Hemisuccinate / administration & dosage, Middle Aged, Pulmonary Alveoli / pathology, Radiography, Thoracic, Recurrence, Scleroderma, Systemic / drug therapy, Time Factors, Tomography, X-Ray Computed, Methylprednisolone Hemisuccinate

Diffuse alveolar hemorrhage (DAH) is a life-threatening clinicopathologic condition caused by accumulation of intra-alveolar red blood cells (RBCs) after disruption of the alveolar-capillary basement membrane that is often seen as a complication of various diseases, but is rare in systemic sclerosis. A 46-year-old female with systemic sclerosis presented to the emergency department complaining of right-sided chest pain. Initially, her electrocardiogram and chest X-ray (CXR) were unremarkable; however, she progressively decompensated into acute respiratory failure resulting in intubation. Repeat CXR and computed tomography scan showed diffuse bilateral alveolar infiltrates and pleural effusions. Video bronchoscopy with bronchoalveolar lavage showed numerous RBCs, neutrophils, macrophages, and respiratory epithelial cells consistent with acute DAH. She was started on intravenous pulse-dosing Solu-Medrol 1 g daily for 5 days. One month later, the patient returned with intractable nausea and vomiting. Again, she went into acute respiratory distress with a PaO2 of 59 while on a 10-L non-rebreather mask. CXR revealed development of alveolar infiltrates in the right lung. A bronchoscopy with bronchoalveolar lavage again showed numerous RBCs and neutrophils along with staining positive for hemosiderin-laden macrophages. Systemic sclerosis with alveolar hemorrhage is a rare occurrence; however, most cases are single episodes of hemorrhage, whereas we present a case with 2 confirmed episodes within 30 days. Its life-threatening nature makes a systemic approach and aggressive treatment crucial to decreasing morbidity and mortality-making it a diagnosis that should not be overlooked, especially in patients with nonspecific symptoms.
"White cord syndrome" of acute tetraplegia after anterior cervical decompression and fusion for chronic spinal cord compression: a case report
Authors: Kingsley R Chin, Jason Seale, Vanessa Cumming
Journal: Case Rep Orthop (2013)

Paralysis is the most feared postoperative complication of ACDF and occurs most often due to an epidural hematoma. In the absence of a clear etiology, inadequate decompression or vascular insult such as ischemia/reperfusion injury are the usual suspects. Herewith we report a case of complete loss of somatosensory evoked potentials (SSEPs) during elective ACDF at C4-5 and C5-6 followed by postoperative C6 incomplete tetraplegia without any discernible technical cause. A postoperative MRI demonstrated a large area of high signal changes on T2-weighted MRI intrinsic to the cord "white cord syndrome" but no residual compression. This was considered consistent with spinal cord gliosis with possible acute edema. The acute decompression of the herniated disc resulted in cord expansion and rush-in reperfusion. We postulate that this may have led to disruption in the blood brain barrier (BBB) and triggered a cascade of reperfusion injuries resulting in acute neurologic dysfunction. At 16 months postoperatively our patient is recovering slowly and is now a Nurick Grade 4.
Percutaneous stenting of left hepatic vein followed by Ex vivo Liver Resection and Autotransplantation in a patient with hepatic alveolar echinococcosis with Budd-Chiari syndrome
Authors: Yu Zhang, Ping Xie, Chong Yang, Hongji Yang, Jun Liu, Guo Zhou, Shaoping Deng, Wan Yee Lau
Journal: Int J Surg Case Rep (2020)
Keywords: autotransplantation, budd-chiari syndrome, hepatic alveolar echinococcosis, hepatic venous stenting
MeSH terms: Case Reports

Background and aims:
Infiltration of hepatic venous outflow in hepatic alveolar echinococcosis can lead to development of Budd-Chiari syndrome. Medical treatment of this condition is generally unsatisfactory. Radical hepatic resection is impossible for extensive parasitic involvement of liver. This is a case report on a patient who was successfully treated with percutaneous stenting of left hepatic vein followed by Ex vivo Liver Resection and Autotransplantation (ELRA).
Methods:
Using the transjugular approach, a metal mesh stent was placed in the left hepatic vein of a 45-year-old man who presented with Budd-Chiari syndrome. After disappearance of ascites and improvement in liver function, Ex vivo Liver Resection and Autotransplantation were performed.
Results:
The patient underwent left hepatic vein stenting for Budd-Chiari syndrome without complication. Three months later, liver biopsy showed fibrous proliferation of interlobular portal areas and normal hepatic lobules. After successful Ex vivo Liver Resection and Autotransplantation, follow-up examination at 6 months showed normal liver function and no evidence of recurrence.
Conclusions:
Allotransplantation is an accepted treatment for advanced hepatic alveolar echinococcosis with Budd-Chiari syndrome. However, shortage of organ donors and need for immunosuppression are challenging problems. In selected patients with hepatic vein stenoses presenting as Budd-Chiari syndreme, percutaneous stenting of hepatic veins followed by ex vivo liver resection and autotransplantation represent an alternative curative treatment option.
Orthodontic management of congenitally missing maxillary lateral incisors: a case report
Authors: Sergio Paduano, Iacopo Cioffi, Roberto Rongo, Antonello Cupo, Rosaria Bucci, Rosa Valletta
Journal: Case Rep Dent (2014)

This case report describes the orthodontic treatment of a woman, aged 15 years, with permanent dentition, brachyfacial typology, with congenitally missing maxillary lateral incisors. Multibracket straightwire fixed appliance was used to open the space for dental implant placement, and treat the impaired occlusion. The missing lateral incisors were substituted with oral implants.
Case Report: Disseminated Nocardiosis Caused by Nocardia vulneris in a Patient With Macroglobulinemia
Authors: Fulan Qiu, Zhiyi Ma, Rongrong Zhong, Haonan Huang, Yuehua Wang, Hui Liu
Journal: Front Public Health (2022)
Keywords: 16s rrna, nocardia vulneris, disseminated nocardiosis, linezolid, macroglobulinemia, mass spectrometry, minocycline, trimethoprim-sulfamethoxazole
MeSH terms: Anti-Infective Agents, Nocardia Infections / diagnosis, Nocardia Infections / drug therapy, Nocardia, Waldenstrom Macroglobulinemia, Case Reports, Research Support, Non-U.S. Gov't, Amikacin / therapeutic use, Humans, Linezolid / therapeutic use, Male, Microbial Sensitivity Tests, Middle Aged, Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use, Anti-Infective Agents, Trimethoprim, Sulfamethoxazole Drug Combination, Amikacin, Linezolid, Nocardia vulneris

This report describes a case of disseminated nocardiosis, caused by Nocardia vulneris, in a 61-year-old man with macroglobulinemia and presenting with repeated fever, cough, shortness of breath, and muscle pain. The isolated Nocardia strain was resistant to ciprofloxacin, but susceptible to amikacin, gentamicin, tobramycin, linezolid, trimethoprim-sulfamethoxazole, amoxicillin/clavulanic, moxifloxacin, ceftriaxone, cefotaxim, and imipenem. The patient was started on combined meropenem and doxycycline treatment, followed by trimethoprim-sulfamethoxazole, which was subsequently switched to a combination treatment of linezolid, amikacin, and trimethoprim-sulfamethoxazole. The patient recovered, and his condition remained stable. Although infection by Nocardia vulneris is rare, and it is easy to miss detection in clinical practice, clinicians should be aware of the possibility of this infection. In addition, the MIC value of the drug sensitivity test should be ascertained when there is a wide choice of medicines. The current case was treated successfully with linezolid, amikacin, and trimethoprim-sulfamethoxazole. In cases of disseminated nocardiosis, the patient should be treated with antimicrobial therapy for at least 12 months. Furthermore, bacteriological examination and antimicrobial susceptibility testing should be performed regularly.