OpenMed/multicare-articles huggingface dataset:
Case Report: Autoimmune Hemolysis Anemia After Dihydroartemisinin and Piperaquine for Uncomplicated Plasmodium falciparum Malaria
Authors: Marion Louvois, Loïc Simon, Christelle Pomares, Pierre-Yves Jeandel, Elisa Demonchy, Michel Carles, Pascal Delaunay, Johan Courjon
Journal: Front Med (Lausanne) (2022)
Keywords: artemisinin derivatives, artemisinin-based combination, autoimmune, direct antiglobulin test, hemolytic anemia, malaria
MeSH terms: Case Reports

Malaria is still an endemic disease in Africa, with many imported cases in Europe. The standard treatment is intravenous artesunate for severe malaria and oral artemisinin-based combination therapy (ACT) for uncomplicated malaria. Delayed hemolytic anemia (DHA) after intravenous artesunate has been extensively described, and guidelines recommend biological monitoring until 1 month after the end of the treatment. A link with an autoimmune process is still unsure. Nevertheless, cases with positive direct antiglobulin test (DAT) have been reported. Conversely, DHA is not recognized as an adverse effect of oral ACT. Previously, only few cases of DHA occurring after oral ACT without intravenous artesunate administration have been reported. We report the case of a 42-year-old man returning from Togo. He was treated with dihydroartemisinin/piperaquine combination for uncomplicated Plasmodium falciparum malaria, with low parasitemia. Nine days after the end of the treatment, the patient developed hemolytic anemia with positive DAT. Eventually, the patient recovered after corticotherapy. After excluding common causes of autoimmune hemolytic anemia, we considered that dihydroartemisinin/piperaquine treatment was involved in this side effect.
Unusual Presentation of Primary Squamous Cell Carcinoma of Mandible
Authors: Karpagavalli Shanmugasundaram, Sathasiva Subramanian, Vaishnavi Vedam, Vimal Kumar
Journal: Case Rep Pathol (2016)
MeSH terms: Case Reports

Carcinoma arising primarily from the jaw is a locally aggressive lesion with poor prognosis. Primary intraosseous carcinoma (PIOC) lesion develops either de novo remnants of odontogenic epithelium, odontogenic cyst/tumor, epithelium remnants, or/and salivary gland residues. We describe very interesting case of primary intraosseous carcinoma of mandible. This extensive lesion was sent for oncological opinion and further management. Due to the uncertainty of diagnostic criteria of PIOC, only few cases of this lesion with a typical presentation have been reported. This article presents a case of primary intraosseous carcinoma with a unique appearance and detailed review stating its clinicopathological correlation.
Spontaneous Macular Hole Closure after Valsalva Retinopathy and Nd:YAG Laser Treatment
Authors: Elcin Suren, Melih Akidan, Muhammet Kazim Erol, Devrim Toslak
Journal: Case Rep Ophthalmol Med (2018)
MeSH terms: Case Reports

Purpose:
The purpose of this report is to present a case who had spontaneous macular hole closure after Nd:YAG laser membranotomy applied to premacular haemorrhage associated with Valsalva retinopathy.
Methods:
Case report.
Results:
A 19-year-old young male patient presented to our clinic with sudden vision loss in his right eye, which had occurred 2 weeks before, following push-up and sit-up exercise. The patient was found to have premacular haemorrhage associated with Valsalva retinopathy. Nd:YAG laser membranotomy was performed. During his follow-up at week 1, full-thickness MH was observed and he was put under observation. At month 6, his vision acuity improved, laser coagulation sites in the fundus disappeared, and macular hole closed spontaneously.
Conclusion:
Macular hole that develops after Nd:YAG laser treatment of Valsalva retinopathy may spontaneously be closed like in our case. However, there is a need for further research to understand the mechanism of closure.
Unilateral gynaecomastia in a 16-month-old boy with neurofibromatosis type 1 - case report and brief review of the literature
Authors: Reinhard E Friedrich, Christian Hagel, Victor-Felix Mautner
Journal: GMS Interdiscip Plast Reconstr Surg DGPW (2015)
Keywords: breast surgery, gynaecomastia, neurofibroma, neurofibromatosis type 1
MeSH terms: Case Reports

Neurofibromatosis type 1 (NF1) is an autosomal dominant disease that shows high penetrance with a wide variability in the phenotype. Prepubertal enlargement of the breast in male subjects affected by this condition is well known, but rarely reported. The present case report describes diagnosis and therapy of unilateral gynaecomastia in a toddler showing integumental stigmata of NF1. Furthermore, the report provides a brief review of the literature concerning this finding in NF1. According to this review, the present case appears to be one of the youngest NF1-affected males affected by gynaecomastia that has been reported.
Successful management of coronary artery rupture with stent-graft: a case report
Authors: Berkay Ekici, Aycan Fahri Erkan, Utku Kütük, Hasan Fehmi Töre
Journal: Case Rep Med (2014)

Perforation of coronary arteries is a relatively rare yet life-threatening complication of percutaneus coronary interventions and is encountered in approximately 0.5% of these procedures. According to the type of coronary perforation, various methods of correction are employed, ranging from conservative approach to emergency cardiac surgery. Coronary stent-grafts are composed of two metal stents and a polytetrafluoroethylene layer between them. Advent of such stents enabled efficient endovascular repair of coronary artery perforation. We present a case of coronary artery perforation which had occurred during stent implantation for the treatment of a bridged segment in the distal portion of the left anterior descending artery. This perforation was successfully managed by implanting a stent-graft.
Extramedullary Leukemia, Presenting at the Cervix of the Uterus
Authors: Nikolaos Tsagkas, Androniki Troussa, George Vorgias, Olympia Tzaida, Nektaria Zagorianakou, Maria Gonidi
Journal: Case Rep Obstet Gynecol (2020)
MeSH terms: Case Reports

Extramedullary relapse of leukemia is encountered more often than in the past. The reason is that leukemia survival rates increase with improved treatment schemes. We present a rare case of involvement of the cervix of the uterus in an adult B Acute Lymphocytic Leukemia (B-ALL) survivor. Relapses affect various organs but rarely the female genital tract. Nevertheless, in this case, a woman with a history of induced amenorrhea due to treatment for leukemia presented to the gynecologist because of vaginal spotting. Colposcopy evaluation of the vagina/cervix, sonography and cytological and histological sampling established the diagnosis of leukemia relapse in the cervix of the uterus. Under these circumstances, our study highlights the rare extramedullary presentation of leukemia in the cervix of the uterus of a young lady considered to be disease-free and listed for bone marrow transplantation. In this rare case of relapse in the cervix of the uterus, Pap smears alarmed physicians, and radiology examinations assisted the diagnostic workup. Still, only biopsy, microscopic evaluation, and immunohistochemistry studies established the exact diagnosis. Prognosis in the situation of extramedullary disease relapse in the female genital tract was poor, but gynecologists' high suspicion led to a prompt diagnosis. Survival is in general limited, but together with high suspicion, multidisciplinary team involvement is imperative to improve the reduced chances of survival.
Cyclophosphamide-induced seizures in a patient with neuropsychiatric systemic lupus erythematosus (NPSLE): A case report
Authors: Lingshu Zhang, Ying Shi, Jingyao Zhang, Jing Wu, Wei Jiang
Journal: Front Immunol (2023)
Keywords: cyclophosphamide, immunotherapy, neuropsychiatric lupus erythematosus, seizure, side effect analysis
MeSH terms: Lupus Erythematosus, Systemic / complications, Lupus Erythematosus, Systemic / diagnosis, Lupus Erythematosus, Systemic / drug therapy, Lupus Vasculitis, Central Nervous System / diagnosis, Lupus Vasculitis, Central Nervous System / drug therapy, Case Reports, Research Support, Non-U.S. Gov't, Cyclophosphamide / adverse effects, Female, Humans, Immunosuppressive Agents / adverse effects, Seizures / chemically induced, Seizures / drug therapy, Cyclophosphamide, Immunosuppressive Agents

Seizures are life-threatening complications of neuropsychiatric systemic lupus erythematosus (NPSLE) and are often associated with poor outcomes. Cyclophosphamide immunotherapy is the mainstay of NPSLE treatment. We report the unique case of a patient with NPSLE who developed seizures soon after her first and second doses of low-dose cyclophosphamide. The exact pathophysiological mechanism underlying cyclophosphamide-induced seizures is not well understood. However, this unusual drug-associated side effect of cyclophosphamide is thought to be due to the drug's unique pharmacology. Clinicians should be aware of this complication to make a correct diagnosis and adjust the immunosuppressive regimens very carefully.
Hepatic Squamous Cell Carcinoma Diagnosed by Endoscopic Ultrasound-Guided Fine-Needle Aspiration
Authors: Koki Yamada, Susumu Shinoura, Kaoru Kikuchi
Journal: Case Rep Gastrointest Med (2021)
MeSH terms: Case Reports

Primary hepatic squamous cell carcinoma (SCC) is a rare malignancy with aggressive clinical features. This is the first case report of a primary hepatic SCC diagnosed by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), which is a reliable and safe procedure for the histopathological diagnosis of liver lesions, even if the percutaneous approach is difficult due to ascites or hypervascularity at the puncture site. A 52-year-old man presented to the emergency department of a tertiary referral hospital with right upper quadrant abdominal pain and abdominal distention. Given the laboratory data, a diagnosis of spontaneous bacterial peritonitis (SBP) was made. Concurrently, an abdominal computed tomography (CT) scan revealed an 8 cm hypodense mass with delayed peripheral enhancement in the left hepatic lobe and paraaortic and perihepatic lymphadenopathy. As persistent ascites precluded percutaneous liver biopsy, we performed EUS-FNA of the liver mass, and the obtained specimen showed SCC. As otorhinolaryngological consultation and whole-body investigations, including chest CT, upper and lower endoscopy, and positron emission tomography CT, were all unremarkable except for the liver lesion and lymph nodes, a diagnosis of primary hepatic SCC with systemic lymph node metastasis was made. After treatment of SBP with antibiotics, we initiated chemotherapy concurrent with radiation therapy, adapted to his liver function. Radiation and three cycles of chemotherapy were not effective as the disease progressed, as seen on the follow-up CT scan, and the patient died of hepatic failure on the 134th day after diagnosis. In conclusion, EUS-FNA was a reliable method for tissue sampling in liver malignancies, particularly in selected patients with contraindications for percutaneous biopsy.
Narrative Exposure Therapy as a treatment for child war survivors with posttraumatic stress disorder: two case reports and a pilot study in an African refugee settlement
Authors: Lamaro P Onyut, Frank Neuner, Elisabeth Schauer, Verena Ertl, Michael Odenwald, Maggie Schauer, Thomas Elbert
Journal: BMC Psychiatry (2005)
MeSH terms: Aversive Therapy / methods, Black People / psychology, Narration, Refugees / psychology, Stress Disorders, Post-Traumatic / therapy, Survivors / psychology, Research Support, Non-U.S. Gov't, Adolescent, Child, Depressive Disorder / psychology, Depressive Disorder / therapy, Developing Countries, Habituation, Psychophysiologic, Humans, Pilot Projects, Somalia / ethnology, Treatment Outcome, Uganda, Warfare

Background:
Little data exists on the effectiveness of psychological interventions for children with posttraumatic stress disorder (PTSD) that has resulted from exposure to war or conflict-related violence, especially in non-industrialized countries. We created and evaluated the efficacy of KIDNET, a child-friendly version of Narrative Exposure Therapy (NET), as a short-term treatment for children.
Methods:
Six Somali children suffering from PTSD aged 12-17 years resident in a refugee settlement in Uganda were treated with four to six individual sessions of KIDNET by expert clinicians. Symptoms of PTSD and depression were assessed pre-treatment, post-treatment and at nine months follow-up using the CIDI Sections K and E.
Results:
Important symptom reduction was evident immediately after treatment and treatment outcomes were sustained at the 9-month follow-up. All patients completed therapy, reported functioning gains and could be helped to reconstruct their traumatic experiences into a narrative with the use of illustrative material.
Conclusions:
NET may be safe and effective to treat children with war related PTSD in the setting of refugee settlements in developing countries.
Posterior Ankle Arthroscopy for Osteochondromatosis of the Posterior Ankle Extra-Articular Space with a Longitudinal Tear of Flexor Hallucis Longus
Authors: Ichiro Tonogai, Koichi Sairyo
Journal: Case Rep Orthop (2020)
MeSH terms: Case Reports

We report a rare case of osteochondromatosis of the posterior ankle extra-articular space with a longitudinal tear of flexor hallucis longus (FHL). A 77-year-old woman was referred to our hospital with an approximately 4-year history of pain and swelling in the right posterior ankle joint without obvious trauma. The pain had worsened in the previous 2 years. On presentation, she had tenderness at the posteromedial and posterolateral ankle. Imaging revealed several ossified loose bodies in the posterior ankle extra-articular space. We removed the loose bodies, performed tenosynovectomy around the FHL, and released the FHL tendon using a posterior arthroscopic technique via standard posterolateral and posteromedial portals. A longitudinal tear and fibrillation were detected in the FHL. The patient was able to return to her daily activities approximately 3 weeks after surgery. At the 1-year follow-up visit, she continued to have minor discomfort and slight swelling on the posteromedial aspect of the right ankle but had no recurrence of the ossified loose bodies. To our knowledge, this is the first report of osteochondromatosis of the posterior ankle extra-articular space with a longitudinal tear of the FHL that was treated by removal of loose bodies, tenosynovectomy around the FHL, and release of the FHL tendon via posterior ankle arthroscopy.
Osteoclastic giant cell rich squamous cell carcinoma of the uterine cervix: a case report and review of the literature
Authors: Lucía Alemán-Meza, Gabriela Sofía Gómez-Macías, Oralia Barboza-Quintana, Raquel Garza-Guajardo, Abelardo Loya-Solis
Journal: Case Rep Pathol (2014)

Cervical carcinoma is the most common malignancy of the female genital tract and represents the second most common malignancy in women worldwide. Histologically 85 to 90% of cervical cancers are squamous cell carcinoma. Osteoclastic giant cell rich squamous cell carcinoma is an unusual histological variant of which only 4 cases have been reported. We present the case of a 49-year-old woman with a 6-month history of irregular vaginal bleeding. Examination revealed a 2.7 cm polypoid mass in the anterior lip of the uterine cervix. The patient underwent hysterectomy with bilateral salpingo-oophorectomy. Microscopically the tumor was composed of infiltrative nests of poorly differentiated nonkeratinizing squamous cell carcinoma. Interspersed in between these tumor cells were numerous osteoclastic giant cells with abundant eosinophilic cytoplasm devoid of nuclear atypia, hyperchromatism, or mitotic activity. Immunohistochemistry was performed; CK and P63 were strongly positive in the squamous component and negative in the osteoclastic giant cells, while CD68 and Vimentin were strongly positive in the giant cell population and negative in the squamous component. The patient received chemo- and radiotherapy for recurrent disease identified 3 months later on a follow-up CT scan; 7 months after the surgical procedure the patient is clinically and radiologically disease-free.
Mazabraud's Syndrome
Authors: Masset Adrien, Bottosso Nadège, Kurth William
Journal: J Belg Soc Radiol (2022)
Keywords: mazabraud, syndrome, fibrous dysplasia, intramuscular myxoma
MeSH terms: Case Reports

Teaching point: Mazabraud's Syndrome defines the association of bone fibrous dysplasia and intramuscular myxoma, sometimes with pathological fractures or deformities in the lower limbs.
Association of nasal nostril stenosis with bilateral choanal atresia: a case report
Authors: Shahin Abdollahifakhim, Mehrnoush Mousaviagdas
Journal: Iran J Otorhinolaryngol (2014)
Keywords: choanal atresia, nostril stenosis, rare case
MeSH terms: Case Reports

Introduction:
Neonatal nasal airway obstruction induces various degrees of respiratory distress. The management of this disease, including surgical repair, will depend on the severity and location of the obstruction. We describe here a case of congenital nasal nostril stenosis that required surgical repair for stenting of both nares after coanal atresia repair.
Case report:
A 2 days old female newborn referred to neonatal department of Tabriz Children's Hospital affiliated to the University of Medical Sciences of Tabriz, Iran on the 3rd of December, 2011 immediately after birth with respiratory distress due to bilateral coanal atresia and nasal hypoplasia with very small nostrils. CT scan showed normal brain and bilateral choanal atresia with normal size Pyriform apertures.
Conclusion:
Nasal obstruction can lead to airway compromise and respiratory distress. Congenital bony nasal deformities are being recognized as an important cause of newborn airway obstruction. Nasal hypoplasia is seen in many craniofacial syndromes. Although our patient had hypoplastic nostrils with respiratory distress due to bilateral coanal atresia, correction of hypoplastic nostrils was necessary for completing the operation of choanal atresia.
Spontaneous Rupture of Leiomyoma Diagnosed Preoperatively with Noncontrast Computed Tomography
Authors: Angel Shan, Rahana Harjee, Patrick McLaughlin, Edward C Jones, Mohamed A Bedaiwy
Journal: Case Rep Obstet Gynecol (2020)
MeSH terms: Case Reports

Background:
Spontaneous rupture of benign uterine fibroids is extremely rare and has been associated with fibroid degeneration. It can cause acute intraperitoneal bleeding requiring immediate surgical intervention.
Case:
A previously healthy 50-year-old, Caucasian, nullipara presented with syncope, hemodynamic instability, and an acute abdomen. Noncontrast computed tomography images showed a positive sentinel clot sign in the pelvis as well as a large uterine fibroid with internal hyperdense clot suggesting acute rupture. Urgent laparotomy and hysterectomy confirmed a ruptured, actively bleeding, uterine fibroid with final pathological diagnosis of a benign leiomyoma.
Conclusion:
Prompt diagnosis and emergency surgical intervention were necessary to control acute hemorrhage from a ruptured uterine fibroid. Noncontrast computed tomography is an important adjunct to contrast-enhanced computed tomography and was vital for diagnosis in this case.
Is hospital discharge administrative data an appropriate source of information for cancer registries purposes? Some insights from four Spanish registries
Authors: Enrique E Bernal-Delgado, Carmen Martos, Natalia Martínez, María Dolores Chirlaque, Mirari Márquez, Carmen Navarro, Lauro Hernando, Joaquín Palomar, Isabel Izarzugaza, Nerea Larrañaga, Olatz Mokoroa, M Cres Tobalina, Joseba Bidaurrazaga, María José Sánchez, Carmen Martínez, Miguel Rodríguez, Esther Pérez, Yoe Ling Chang
Journal: BMC Health Serv Res (2010)
MeSH terms: Hospital Records, Medical Record Linkage, Patient Discharge, Prostatic Neoplasms / diagnosis, Registries, Case Reports, Research Support, Non-U.S. Gov't, Validation Study, Algorithms, Diagnostic Errors, Forms and Records Control, Humans, Male, Population Surveillance / methods, Prostatic Neoplasms / classification, Prostatic Neoplasms / epidemiology, Sensitivity and Specificity, Spain

Background:
The use of hospital discharge administrative data (HDAD) has been recommended for automating, improving, even substituting, population-based cancer registries. The frequency of false positive and false negative cases recommends local validation.
Methods:
The aim of this study was to detect newly diagnosed, false positive and false negative cases of cancer from hospital discharge claims, using four Spanish population-based cancer registries as the gold standard. Prostate cancer was used as a case study.
Results:
A total of 2286 incident cases of prostate cancer registered in 2000 were used for validation. In the most sensitive algorithm (that using five diagnostic codes), estimates for Sensitivity ranged from 14.5% (CI95% 10.3-19.6) to 45.7% (CI95% 41.4-50.1). In the most predictive algorithm (that using five diagnostic and five surgical codes) Positive Predictive Value estimates ranged from 55.9% (CI95% 42.4-68.8) to 74.3% (CI95% 67.0-80.6). The most frequent reason for false positive cases was the number of prevalent cases inadequately considered as newly diagnosed cancers, ranging from 61.1% to 82.3% of false positive cases. The most frequent reason for false negative cases was related to the number of cases not attended in hospital settings. In this case, figures ranged from 34.4% to 69.7% of false negative cases, in the most predictive algorithm.
Conclusions:
HDAD might be a helpful tool for cancer registries to reach their goals. The findings suggest that, for automating cancer registries, algorithms combining diagnoses and procedures are the best option. However, for cancer surveillance purposes, in those cancers like prostate cancer in which care is not only hospital-based, combining inpatient and outpatient information will be required.
Reversible MR Findings in Marchiafava-Bignami Disease
Authors: Carmine Franco Muccio, Luca De Lipsis, Rossella Belmonte, Alfonso Cerase
Journal: Case Rep Neurol Med (2019)
MeSH terms: Case Reports

Marchiafava-Bignami Disease (MBD) is a toxic demyelinating disease often diagnosed in chronic alcoholics. The disease process typically involves the corpus callosum and clinically presents with various manifestations resulting in MBD type A and type B on the basis of clinical condition, extent of callosal involvement and extracallosal involvement at brain magnetic resonance imaging (MRI), and prognosis. The death rate is high. We report a patient affected by MBD type B, who presented an isolated reversible splenial lesion at brain MRI and achieved a favorable recovery.