OpenMed/multicare-articles huggingface dataset:
Elastofibroma Dorsi: Case Report with Point of Care Ultrasound Primary Care Applications
Authors: Trent Mazer, Karam Nabeel Gagi, Michael Bishop
Journal: POCUS J (2021)
Keywords: elastofibroma dorsi, lipoma, primary care, shoulder pain
MeSH terms: Case Reports

Elastofibroma dorsi (ED) is an uncommon, benign, slow-growing soft tissue tumor with an unclear etiology. The growth often presents as a local deformity with mild pain or discomfort in the subscapular region of geriatric populations. The following paper discusses a 73 year old female with mildly painful ED who presented to her primary care physician. We further review current literature on epidemiology, utilization of point of care ultrasound (POCUS) and treatment options.
Forty-nine-month survival in a metastatic renal cell carcinoma patient across six lines of targeted therapy
Authors: T Raja
Journal: Ecancermedicalscience (2014)
Keywords: everolimus, metastatic renal cell carcinoma, sequential therapy
MeSH terms: Case Reports

A better understanding of the aetiopathogenetic molecular targets in renal cell carcinoma (RCC) and the subsequent advent of targeted therapeutic agents have greatly improved the management and prognosis of RCC and patient survival. However, optimising therapeutic outcomes through appropriate sequential or combination therapy remains a challenge. Our 45-year-old male patient presented with metastatic renal cell carcinoma (mRCC); we effectively managed his aggressive, progressive disease across six lines of treatment, including sequential monotherapy and combination therapy, with targeted agents like sunitinib, everolimus, sorafenib, temsirolimus, and bevacizumab, resulting in a >48-month survival. Appropriate therapy with agents that have non-overlapping target profiles minimised treatment-related toxicities, enabling our patient to tolerate therapy at full doses. This case represents a good example of a significant clinical benefit of targeted therapy beyond the fourth line in mRCC. The survival and prognosis of mRCC patients may thus be significantly improved with the suitable use of newer targeted agents.
Melkersson-Rosenthal Syndrome with Orofacial Swelling and Recurrent Lower Motor Neuron Facial Nerve Palsy: A Case Report and Review of the Literature
Authors: Jerome Okudo, Yemi Oluyide
Journal: Case Rep Otolaryngol (2015)

Melkersson-Rosenthal Syndrome (MRS) is a rare otoneurologic condition, which is poorly understood and often underdiagnosed. Etiology and incidence are unclear, although infectious, inflammatory, and genetic causes have been implicated. Recurrent facial nerve palsy, facial swelling, and fissured tongue are the symptoms and signs of this condition. However, this triad is not typical in all patients as patients may present with one or more of the symptoms, which makes management of this condition difficult. Steroids may prove to be useful especially in patients who have facial nerve palsy. In this case report, we have described a 46 year-old Caucasian male who presented to the clinic for the evaluation of orofacial swelling and left facial deviation with a history of multiple treatments for recurrent lower motor neuron type facial nerve palsy.
Isolated parachute mitral valve in a 29 years old female; a case report
Authors: Mehrnoush Toufan, Seyed Sajjad Mahmoudi
Journal: J Cardiovasc Thorac Res (2016)
Keywords: isolated parachute mitral valve, mitral stenosis, shone’s complex
MeSH terms: Case Reports

A 29-year old female patient was referred to our hospital for evaluation of dyspnea NYHA class I which begun from several months ago. The only abnormal sign found on physical examination was a grade 2/6 systolic murmur at the apex position without radiation. Echocardiography revealed normal left and right ventricular sizes and systolic function, and only one papillary muscle in left ventricular (LV) cavity which all chordae tendineae inserted into that muscle. The mitral valve orifice was eccentrically located at the lateral side with mild to moderate mitral regurgitation but without significant mitral stenosis. No other congenital heart anomalies were identified. Thus, the final diagnosis was isolated parachute mitral valve (IPMV). She was one of the very rare IPMV cases have ever been reported in adults.
Case Report: Endocapillary Glomerulopathy Associated With Large Granular T Lymphocyte Leukemia
Authors: Tao Zhao, Nan Hu, Xiaojuan Yu, Tao Su
Journal: Front Immunol (2022)
Keywords: acute kidney injury, endocapillary glomerulonephritis, histology, immunohistochemistry, large granular lymphocyte (lgl) leukemia
MeSH terms: Glomerulonephritis / complications, Glomerulonephritis / diagnosis, Leukemia, Large Granular Lymphocytic / diagnosis, Leukemia, Large Granular Lymphocytic / etiology, Case Reports, Research Support, Non-U.S. Gov't, Biomarkers, Biopsy, Combined Modality Therapy, Disease Susceptibility, Fatal Outcome, Glomerulonephritis / etiology, Humans, Immunohistochemistry, Immunophenotyping, Leukemia, Large Granular Lymphocytic / therapy, Male, Middle Aged, Symptom Assessment, T-Lymphocytes / metabolism, T-Lymphocytes / pathology, Biomarkers

Large granular T lymphocyte leukemia (T-LGLL) is a rare indolent lymphocyte leukemia. The clonal proliferation of T cells, which is related to STAT3 gene mutation and abnormal Fas-mediated apoptosis pathway after cell activation, plays a major role in disease progression. Some studies have found that the exogenous and continuous stimulation of endogenous antigens, such as virus infection, is related to the pathogenesis of T-LGLL. The renal pathological manifestations of T-LGLL have rarely been described. In this study, we report a case of T-LGLL with kidney involvement as proteinuria, acute kidney injury, with the appearance of circulating T-LGL infiltrating intra-glomerular capillaries, and endocapillary glomerulopathy. We also summarize reported cases of renal injury associated with LGLL.
Toxoplasmic encephalitis after allogeneic hematopoietic stem cell transplantation
Authors: Feyza Izci Cetinkaya, Necati Mumcu, Gamze Kalin Unuvar, Aysegul Ulu Kilic, Leylagul Kaynar
Journal: North Clin Istanb (2022)
Keywords: allogeneic stem cell transplantation, encephalitis, toxoplasmosis
MeSH terms: Case Reports

Cerebral toxoplasmosis is a rare but often life-threatening infection after hematopoietic stem cell transplantation (HSCT). In such cases, early diagnosis and initiation of treatment are vital. We describe a case of cerebral toxoplasmosis in a patient who underwent HSCT for acute myeloid leukemia. Infection was diagnosed with polymerase chain reaction (PCR) test of cerebrospinal fluid and cranial magnetic resonance imaging scan. The patient treated with trimethoprim-sulfamethoxazole and clindamycin combination. However, she died from nosocomial infection after 15 days of treatment. This life-threatening infection should be considered in a patient who is post-HSCT present with neurologic symptoms and brain lesions. PCR is an important and rapid diagnostic tool for toxoplasmosis. Cranial imaging scan and PCR should be used together to diagnosed.
Olfactory neuroblastoma treated by endoscopic surgery followed by combined external beam radiation and gamma knife for optic nerve and chiasm sparing: a case report
Authors: Hansi Z Jiang, Ameer L Elaimy, Guy C Jones, Alexander R Mackay, Robert K Fairbanks, Wayne T Lamoreaux, John J Demakas, Barton S Cooke, Christopher M Lee
Journal: Case Rep Med (2011)
MeSH terms: Case Reports

We describe the multimodality treatment regimen of a 53-year-old man diagnosed with olfactory neuroblastoma (Kadish stage C) in the right nasal cavity extending into the ethmoid sinus and across the cribriform plate. Endoscopic surgery for tumor resection was followed by a combination of external beam radiotherapy and stereotactic radiosurgery boost with concurrent chemotherapy. The novel combination of dual radiation therapies allowed for the preservation of the nearby optic structures while providing an adequate dosage to a sufficient volume of the afflicted tissue.
Pleuroperitoneal leak complicating peritoneal dialysis: a case series
Authors: C Kennedy, C McCarthy, S Alken, J McWilliams, R K Morgan, M Denton, P J Conlon, C Magee
Journal: Int J Nephrol (2011)
MeSH terms: Case Reports

Pressure related complications such as abdominal wall hernias occur with relative frequency in patients on peritoneal dialysis. Less frequently, a transudative pleural effusion containing dialysate can develop. This phenomenon appears to be due to increased intra-abdominal pressure in the setting of congenital or acquired diaphragmatic defects. We report three cases of pleuroperitoneal leak that occurred within a nine-month period at our institution. We review the literature on this topic, and discuss management options. The pleural effusion resolved in one patient following drainage of the peritoneum and a switch to haemodialysis. One patient required emergency thoracocentesis. The third patient developed a complex effusion requiring surgical intervention. The three cases highlight the variability of this condition in terms of timing, symptoms and management. The diagnosis of a pleuroperitoneal leak is an important one as it is managed very differently to most transudative pleural effusions seen in this patient population. Surgical repair may be necessary in those patients who wish to resume peritoneal dialysis, or in those patients with complex effusions. Pleuroperitoneal leak should be considered in the differential diagnosis of a pleural effusion, particularly a right-sided effusion, in a patient on peritoneal dialysis.