OpenMed/multicare-articles huggingface dataset:
Multifunctional Templates for Minimized Osteotomy, Implantation, and Palatal Distraction with a Mini-Screw-Assisted Expander in Schizodontism and Maxillary Deficit
Authors: Manfred Nilius, Katrin Hess, Dominik Haim, Bernhard Weiland, Guenter Lauer
Journal: Case Rep Dent (2020)
MeSH terms: Case Reports

Purpose:
Schizodontism is complete separation of a dental germ. It results in a twin tooth and supernumerary teeth. The treatment of transverse constriction in combination with supernumerary dental germs and impacted central incisors can pose a challenge, especially in young patients, when the number of permanent teeth is not adequate to ensure secure anchorage. The use of navigation templates based on three-dimensional X-ray images allows for precise insertion of temporary mini-implants for the acquisition of palatal distractors. In addition, templates allow for minimally invasive biopsies and osteotomies.
Methods:
The treatment of schizodontism, dentitio tarda, and transverse constriction is to be assessed as an interdisciplinary method by using mini-screw-assisted devices. Minimized osteotomy of impacted supernumerary teeth or dental implantation can be carried out in a one-step-procedure based on digital preplanning and prefabrication of orthodontic devices.
Results:
Multifunctional templates allow for early planning, preoperative fabrication, and intraoral fixation of orthodontic appliances. In the case of an adolescent patient, a sustainable, interdisciplinary treatment concept could be demonstrated that shows age-appropriate gnathological development and stable growth conditions over a follow-up period of 10 years.
Conclusion:
One can likely assume that multifunctional templates allow for minimally invasive one-step surgeries as an interdisciplinary tool between orofacial surgery and modern orthodontics.
The Natural History of X-Linked Lymphoproliferative Disease (XLP1): Lessons from a Long-Term Survivor
Authors: Yike Jiang, Mihail Firan, Sarada L Nandiwada, Anaid Reyes, Rebecca A Marsh, Tiphanie P Vogel, Joud Hajjar
Journal: Case Reports Immunol (2020)
MeSH terms: Case Reports

X-linked lymphoproliferative disease (XLP1) is a rare primary immunodeficiency characterized by EBV-triggered immune dysregulation, lymphoproliferation, dysgammaglobulinemia, and lymphoma. Early childhood mortality from overwhelming inflammation is expected in most patients. The only curative therapy is hematopoietic stem cell transplant (HSCT); however, whether to perform HSCT on an asymptomatic patient remains debatable. This uncertainty arises because the natural history of XLP1 patients without transplantation is not clear. In this case report, we present the natural history of XLP1 in a 43-year-old male patient who did not receive HSCT. We also review the literature on untransplanted XLP1 patients who lived into mid-adulthood. Despite surviving childhood presentations that are typically fatal, we found that these rare patients remain susceptible to manifestations of XLP1 decades later.
Fatal Blastoid Variant Mantle Cell Lymphoma in a Patient with Sjögren's Syndrome
Authors: Fabio Bonilla-Abadía, Manuel A Pérez, Evelyn Muñoz-Buitrón, Joaquín D Rosales, Carlos A Cañas, Gabriel J Tobón
Journal: Case Rep Rheumatol (2013)

Primary Sjögren's syndrome (pSS) is an autoimmune disorder of the exocrine glands presenting with progressive ocular and oral dryness, parotid gland enlargement, and often with extraglandular manifestations. In this group of patients the risk of development of non-Hodgkin's lymphoma is 16-fold compared to healthy population, mainly of the MALT lymphoma type. This case reports a 52-year-old woman with pSS developing a progressively growing mass at face and neck compatible with blastoid variant mantle cell lymphoma and a fatal outcome.
Rotational Thromboelastometry-Guided Venoarterial Extracorporeal Membrane Oxygenation in the Treatment of Amniotic Fluid Embolism
Authors: Jillian K Wothe, Elizabeth Elfstrand, Michael R Mooney, Donald D Wothe
Journal: Case Rep Obstet Gynecol (2022)
MeSH terms: Case Reports

Amniotic fluid embolism (AFE) is a rare and often fatal complication of pregnancy that occurs during the puerperium. The low incidence of AFE has resulted in few large studies, which makes evidence-based management of AFE challenging. The use of extracorporeal membrane oxygenation (ECMO) has been reported but is limited by availability and challenges managing anticoagulation. In this report, we detail the case of a 29-year-old female who suffered from an AFE leading to cardiac arrest and disseminated intravascular coagulopathy. She was treated with protocolized A-OK (adenosine, ondansetron, and ketorolac), emergency c-section, cardiopulmonary resuscitation, massive blood transfusion, and rotational thromboelastometry-guided ECMO, allowing her to forgo initial anticoagulation. After a prolonged rehabilitation with initial poor neurological status, she made a complete recovery. In this report, we describe the protocols that contributed to her recovery and detail management of complicated AFE for other clinicians.
Partial Nephrectomy for a Massive Sporadic Renal Angiomyolipoma: Case Report and Review of the Literature
Authors: Jacob Albersheim-Carter, Molly Klein, Paari Murugan, Christopher J Weight
Journal: Case Rep Urol (2016)

Introduction. Angiomyolipomas are the most common benign tumor of the kidney, associated with Tuberous Sclerosis in 20% of cases and arising sporadically in 80% of cases. Renal angiomyolipomas are neoplasms of mesenchymal origin with varying proportions of vasculature, smooth muscle spindle cells, and adipocytes, making management of such neoplasms a challenging endeavor. Possible management options include partial or radical nephrectomy and segmental renal artery embolization. Case Presentation. A 61-year-old woman admitted for a large retroperitoneal hemorrhage was discovered to have a giant, sporadic, 3818.3 g, 30.0 × 26.5 × 18.0 cm left perinephric angiomyolipoma. Given her hemodynamic instability upon presentation, she underwent segmental arterial embolization, followed by an open left partial nephrectomy. Ten-month follow-up revealed no noticeable loss of renal function. Discussion. Literature review revealed occasional renal angiomyolipomas of comparable size, with all angiomyolipomas larger than this requiring treatment with radical nephrectomy. Conclusion. We show that nephron-sparing surgery may be considered in the treatment of even the largest of renal angiomyolipomas.
Multiple Retinal Holes Secondary to Valsalva Retinopathy
Authors: Rajya L Gurung
Journal: Case Rep Ophthalmol Med (2018)
MeSH terms: Case Reports

Valsalva retinopathy is a common condition but retinal holes secondary to Valsalva retinopathy are rarely reported. The author believes this to be the first report to describe multiple retinal holes after hyaloidotomy for Valsalva retinopathy.
A long-term surviving patient with recurrent low-grade serous ovarian carcinoma treated with the MEK1/2 inhibitor, selumetinib
Authors: Munetaka Takekuma, Kwong K Wong, Robert L Coleman
Journal: Gynecol Oncol Res Pract (2016)
Keywords: kras mutation, low-grade serous ovarian cancer, mek inhibitor, selumetinib
MeSH terms: Case Reports

Background:
Selumetinib is a potent, selective, orally available, and non-ATP competitive small molecule inhibitor of mitogen-activated protein kinase kinase 1/2 (MEK1/2) that has demonstrated single agent activity in a number of solid tumor including recurrent low-grade serous ovarian carcinoma (LGSOC). However, the long-term prognosis of patients who receive selumetinib, as well as the late toxicity of the agent, have not yet been described.
Case presentation:
In this case report, we present a patient with recurrent LGSOC with KRAS mutation whose tumor has not progressed and who has maintained a good general condition without severe toxicities following treatment with selumetinib for more than 7 years. Next generation sequencing of her tumor revealed a G12V mutation in KRAS. MAPK signaling inhibition plays a role in the biology of LGSOC.
Conclusions:
Although biomarkers have yet to definitively define patients with LGSOC who are likely to respond to therapy, exploration of specific alterations should be pursued in an excersie to develop a reliable companion diagnostic test.
Multiparametric Ultrasound (mpUS) of a Rare Testicular Capillary Hemangioma
Authors: Paul Spiesecke, Thomas Fischer, Carsten Stephan, Andreas Maxeiner, Bernd Hamm, Markus Lerchbaumer
Journal: Case Rep Radiol (2019)
MeSH terms: Case Reports

Capillary hemangioma is a rare entity among testicular tumors. We demonstrate the case of an 18-year-old patient with palpatoric and sonographic conspicuous left testicle and negative serum tumor markers (α-fetoprotein, β-human chorionic gonadotropin, and lactate dehydrogenase). Ultrasound (US) imaging represented an isoechogenic lesion with high vascularization in both power Doppler and microflow imaging with central feeding artery. Both strain elastography and shear wave elastography demonstrated a stiff lesion compared to surrounding testicular tissue. While contrast-enhanced ultrasound (CEUS) clearly depicted high vascular load, time intensity curve (TIC) analysis was able to show shorter median transit time, higher peak enhancement, and higher wash-in area under the curve compared to regular testicular tissue. Histopathological examination revealed a lobular constructed and rich vascularized proliferation without cellular atypia and feeder vessels with positive reaction to CD34, CD31, CD99, and Vimentin. Proliferative activity was quantified to 3-5% by Ki-67 index. Two days after surgery, the patient could leave the hospital in subjective wellbeing. While histology remains the gold standard to make a precise diagnosis of capillary hemangiomas due to small case numbers and variety of this benign tumor, the combination of multiparametric US and clinical information may be a promising future tool in preoperative assessment.
A Laparoscopic Management Combined with a Flexible Ureteroscope for Ureteral Polyps of More Than 3 cm Length
Authors: Mitsunori Matsuo, Kousuke Ueda, Kiyoaki Nishihara, Makoto Nakiri, Shunsuke Suyama, Katsuaki Chikui, Shuichiro Hayashi, Hirofumi Kurose, Naoyuki Ogasawara, Shigetaka Suekane, Tsukasa Igawa
Journal: J Endourol Case Rep (2016)
MeSH terms: Case Reports

Ureteral polyps are benign tumors of the ureter, which are relatively rare. The etiology has proposed various hypotheses, involving chronic inflammation and congenital disease. Most of them are commonly diagnosed in the upper ureter including the ureteropelvic junction. Some studies have reported polypectomy using a holmium laser, but several studies presented laparoscopic ureteroureterostomy for patients in whom the mentioned procedure is difficult. We underwent laparoscopic ureteroureterostomy with a combination of flexible ureteroscope for ureteral polyps of more than 3 cm length. We used ureteroscopy with a laparoscopic approach to minimize the length of ureter resection. Using the light guide of ureteroscopy is useful to decide the exact and minimal excision range for ureteroureterostomy.
Surgical treatment in oligometastatic breast cancer
Authors: Catalina Vargas, Cristóbal Maiz, María Elena Navarro, David Oddó, César Sánchez, Marisa Bustos, Mauricio Camus
Journal: Ecancermedicalscience (2019)
Keywords: locoregional treatment, metastatic breast cancer, oligometastatic, stage iv breast cancer, surgery
MeSH terms: Case Reports

Metastatic breast cancer (MBC) management is based on systemic treatment (ST), while the local therapy role remains controversial. We present the case of a 36-year-old woman with a diagnosis of hormone receptor-positive and human epidermal growth factor receptor type 2-positive breast cancer and isolated sternal metastasis, who received neoadjuvant ST with complete remission and later primary tumour surgery. Oligometastatic patients are a subgroup of MBC that can benefit from aggressive local therapies, even with curative intent.
Case report: Vitiligo-like toxicity due to ribociclib during first-line treatment of metastatic breast cancer: two cases of premature interruption of therapy and exceptional response
Authors: Mariangela Pasqualoni, Armando Orlandi, Antonella Palazzo, Giovanna Garufi, Maria Chiara Cannizzaro, Letizia Pontolillo, Sergio Pannunzio, Claudia Cutigni, Pietro Sollena, Francesco Federico, Emilio Bria, Giampaolo Tortora
Journal: Front Oncol (2023)
Keywords: cdk4/6 inhibitor, breast cancer, lymphocytic infiltration, skin adverse event, vitiligo
MeSH terms: Case Reports

Cancer treatment-related adverse events (AEs) are sometimes associated with outcomes for cancer patients, especially with the newest therapies such as target therapy and immunotherapy. A few years ago, the first-line therapy for hormone-receptor-positive metastatic breast cancer (mBC) patients has been deeply changed by the introduction of cyclin-dependent kinase (CDK) 4/6 inhibitors, and now, we are improving our knowledge about their AEs and significance in clinical practice. Here, we report our experience with two cases of vitiligo-like lesions that occur early during treatment with ribociclib. We tried to change the CDK4/6 inhibitor for one patient, but the skin reaction persisted. Both patients retained only the endocrine therapy alone and had an unexpected durable progression-free survival (PFS). Some data on skin toxicities, including vitiligo-like lesions by CDK4/6 inhibitors, have recently been reported in the literature, but for the first time, we highlight a possible correlation with improved survival outcomes of patients. Uncovering the etiology of this toxicity, verifying the involvement of the immune system, and demonstrating a possible positive impact in survival represent an intriguing research objective for the near future.
Breast Implant-Associated Anaplastic Large Cell Lymphoma
Authors: P L Moori, F Ibison, D Jacob, J Iddon
Journal: Case Rep Pathol (2020)
MeSH terms: Case Reports

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare, non-Hodgkin lymphoma which arises within the capsules of breast implants. These particular tumours have expression of CD30 and are negative for Anaplastic Lymphoma Kinase (ALK). Here, we report a case of BIA-ALCL in a 48-year-old woman post breast reconstruction. This case report is aimed at raising awareness and education on the significance of considering the development of BIA-ALCL in cases where cytology is negative and helping better understand this disease process.
Differential Diagnosis of COVID-19 Pneumonia in Cancer Patients Received Radiotherapy
Authors: Qi Zeng, Caihua Tang, Lisi Deng, Sheng Li, Jiani Liu, Siyang Wang, Hong Shan
Journal: Int J Med Sci (2020)
Keywords: covid-19, multidetector computed tomography, pneumonia, radiation pneumonitis
MeSH terms: Betacoronavirus, Coronavirus Infections / diagnostic imaging, Diagnosis, Differential, Neoplasms / radiotherapy, Pneumonia, Viral / diagnostic imaging, Radiation Pneumonitis / diagnostic imaging, Case Reports, Adult, COVID-19, COVID-19 Testing, Clinical Laboratory Techniques, Coronavirus Infections / diagnosis, Esophageal Neoplasms / diagnostic imaging, Esophageal Neoplasms / pathology, Esophageal Neoplasms / radiotherapy, Female, Humans, Lung Neoplasms / diagnostic imaging, Lung Neoplasms / radiotherapy, Male, Middle Aged, Nasopharyngeal Neoplasms / diagnostic imaging, Nasopharyngeal Neoplasms / pathology, Nasopharyngeal Neoplasms / radiotherapy, Neoplasms / virology, Pandemics, Retrospective Studies, SARS-CoV-2, Tomography, X-Ray Computed

Background: During the outbreak period of COVID-19 pneumonia, cancer patients have been neglected and in greater danger. Furthermore, the differential diagnosis between COVID-19 pneumonia and radiation pneumonitis in cancer patients remains a challenge. This study determined their clinical presentations and radiological features in order to early diagnose and separate COVID-19 pneumonia from radiation pneumonitis patients promptly. Methods and Findings: From January 21, 2020 to February 18, 2020, 112 patients diagnosed with suspected COVID-19 were selected consecutively. A retrospective analysis including all patients' presenting was performed. Four patients from 112 suspected individals were selected, including 2 males and 2 females with a median age of 54 years (range 39-64 years). After repeated pharyngeal swab nucleic acid tests, 1 case was confirmed and 3 cases were excluded from COVID-19 pneumonia. Despite the comparable morphologic characteristics of lung CT imaging, the location, extent, and distribution of lung lesions between COVID-19 pneumonia and radiation pneumonitis differed significantly. Conclusions: Lung CT imaging combined with clinical and laboratory findings can facilitate early diagnosis and appropriate management of COVID-19 pneumonia with a history of malignancy and radiation therapy.
Case Report: Expanding Clinical, Immunological and Genetic Findings in Sideroblastic Anemia With Immunodeficiency, Fevers and Development Delay (SIFD) Syndrome
Authors: Leonardo Oliveira Mendonca, Alex Isidoro Prado, Izelda Maria Carvalho Costa, Marcia Bandeira, Rafael Dyer, Samar Freschi Barros, Karen Francine Khöler, Luiz Augusto Marcondes Fonseca, Jorge Kalil, Fabio Morato Castro, Myrthes Anna Maragna Toledo-Barros
Journal: Front Immunol (2021)
Keywords: b-cell deficiency, sifd, trnt1, erythema nodosum, recurrent fever
MeSH terms: Anemia, Sideroblastic / diagnosis, Anemia, Sideroblastic / etiology, Developmental Disabilities / diagnosis, Disease Susceptibility, Fever, Immunologic Deficiency Syndromes / diagnosis, Phenotype, Case Reports, Alleles, Biopsy, DNA Mutational Analysis, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Humans, Lymphocytes / immunology, Lymphocytes / metabolism, Mutation

Since the first description of the syndrome of sideroblastic anemia with immunodeficiency, fevers and development delay (SIFD), clinical pictures lacking both neurological and hematological manifestations have been reported. Moreover, prominent skin involvement, such as with relapsing erythema nodosum, is not a common finding. Up to this moment, no genotype and phenotype correlation could be done, but mild phenotypes seem to be located in the N or C part. B-cell deficiency is a hallmark of SIFD syndrome, and multiple others immunological defects have been reported, but not high levels of double negative T cells. Here we report a Brazilian patient with a novel phenotype of SFID syndrome, carrying multiple immune defects and harboring a novel mutation on TRNT1 gene.
Early onset of capsular contracture after breast augmentation with implant: report of two cases & review of literature
Authors: Subhi M K Zino Alarki, Hatan Mortada, Asma I Abdullah, Hisham Alkhalidi, Musab Alrehaili
Journal: Case Reports Plast Surg Hand Surg (2022)
Keywords: capsular contracture, breast reconstruction, capsulectomy, complications, early-onset
MeSH terms: Case Reports

Capsular contracture (CC) is a local complication caused by an inflammatory reaction that leads to fibrosis. CC commonly occurs after one year of surgery. Hence, there has been no previously reported early onset of CC. Therefore, we report two unusual cases of early onset of post-breast reconstruction capsular contracture.
Protein C Deficiency Caused by a Novel Mutation in the PROC Gene in an Infant with Delayed Onset Purpura Fulminans
Authors: Mariam S Al Harbi, Ayman W El-Hattab
Journal: Case Rep Dermatol Med (2017)
MeSH terms: Case Reports

Protein C is an anticoagulant that is encoded by the PROC gene. Protein C deficiency (PCD) is inherited in an autosomal dominant or recessive pattern. Autosomal dominant PCD is caused by monoallelic mutations in PROC and often presents with venous thromboembolism. On the other hand, biallelic PROC mutations lead to autosomal recessive PCD which is a more severe disease that typically presents in neonates as purpura fulminans. In this report, we describe an 8-month-old infant with autosomal recessive PCD who presented with multiple lumps on his lower extremities at the age of 2 months and later developed purpura fulminans after obtaining a muscle biopsy from the thigh at the age of 5 months. Protein C level was less than 10% and PROC gene sequencing identified a novel homozygous missense mutation, c.1198G>A (p.Gly400Ser). Autosomal recessive PCD typically presents with neonatal purpura fulminans which is often fatal if not recognized and treated early. Therefore, early recognition is critical in preventing morbidity and mortality associated with autosomal recessive PCD.
Actinomyces europaeus Isolated from a Breast Abscess in a Penicillin-Allergic Patient
Authors: Sarah E White, Stephen D Woolley
Journal: Case Rep Infect Dis (2018)
MeSH terms: Case Reports

This is a case of Actinomyces europaeus in the breast abscess of a penicillin-allergic woman. The mainstay of treatment for actinomycosis is penicillin, and there is a lack of literature describing nonpenicillin treatment options. A 69-year-old woman presented acutely with a breast abscess which was managed with incision and drainage and antibiotic therapy to good response. 21 days after presentation, Actinomyces were grown from the culture of pus, so the patient was recalled and more rigorous treatment and follow-up were initiated. The penicillin allergy led to difficulty in the identification of an appropriate antimicrobial agent that was also logistically feasible to be given on an outpatient IV basis. IV tigecycline followed by oral clarithromycin was found to be effective treatment.
Urachal sinus presenting with abscess formation
Authors: Jalal Eddine El Ammari, Youness Ahallal, Oussama El Yazami Adli, Mohammed Jamal El Fassi, My Hassan Farih
Journal: ISRN Urol (2011)
MeSH terms: Case Reports

Urachal affections are rare. Their variable ways of presentation may represent a diagnostic challenge. Urachal sinuses are a rare type of these abnormalities. They are usually incidental findings and remain asymptomatic unless a complication (most commonly the infection) occurs. Infection of the urachal sinus would clinically present as purulent umbilical discharge, abdominal pain, and periumbilical mass. We report herein a case of infected urachal sinus in male adult. The diagnosis was suspected clinically and confirmed with ultrasonography and computed tomography scan. A preoperative cysto-fibroscopy showed normal aspect of the bladder and excluded sinus communication. An initial broad spectrum antibiotic therapy followed by complete excision of the sinus and fibrous tract without cuff of bladder has been therefore performed. The postoperative course was uneventful. No recurrence was observed after 18 months of followup. Histological examination did not reveal any sign of malignancy.
Adolescent male with anorexia nervosa: a case report from Iraq
Authors: Maha S Younis, Lava D Ali
Journal: Child Adolesc Psychiatry Ment Health (2012)

This is the first reported case of an adolescent male with anorexia nervosa in Iraq. This disorder is believed to be rare in males across cultures and uncommon for both genders in Arab countries. The patient met the DSM-IV diagnostic criteria for anorexia nervosa. He was hospitalized and received medical and psychiatric treatment at local facilities as discussed below and responded well to treatment.