OpenMed/multicare-articles huggingface dataset:
ST-segment elevation after blunt chest trauma: myocardial contusion with normal coronary arteries or myocardial infarction following coronary lesions
Authors: Amine Ghalem, Hanane Boussir, Kamal Ahsayan, Nabila Ismaili, Noha El Ouafi
Journal: Pan Afr Med J (2017)
Keywords: blunt chest trauma, coronary angiography, myocardial contusion, myocardial infarction
MeSH terms: Myocardial Contusions / diagnosis, ST Elevation Myocardial Infarction / diagnosis, Thoracic Injuries / complications, Wounds, Nonpenetrating / complications, Case Reports, Coronary Vessels / pathology, Electrocardiography, Humans, Interdisciplinary Communication, Male, Middle Aged, Myocardial Contusions / etiology

Cardiac lesions secondary to blunt chest trauma vary from insignificant arrhythmias to fatal cardiac rupture. Of these, a distinction remains difficult; face to ST-segment elevation on ECG with positive cardiac biomarkers, is it a myocardial contusion or a genuine myocardial infarction (MI) secondary to coronary lesions? We report the case of a patient admitted for multiple trauma. Initial assessment showed an ST segment elevation on ECG, along with multiple fractures and abdominal injuries. We would like to discuss, through this case, the similarities and the differences between myocardial infarction due to coronary lesions and myocardial contusion in a traumatic context, but also emphasize the difficulty of striking the right balance between thrombotic and bleeding risks in this situation, and insist on the importance of a multidisciplinary and collegial reflexion so we can offer these patients the best care there is.
A rare case of long-term dialysis catheter-associated Agromyces mediolanus bacteremia: A case report and literature review
Authors: Kanza Haq, Samuel Pan, Enrique Pacheco, Medhat Ghaly
Journal: Clin Nephrol Case Stud (2023)
Keywords: agromyces mediolanus, esrd, catheter-related blood stream infection, endocarditis, hemodialysis
MeSH terms: Case Reports

Agromyces mediolanus is a catalase-positive gram-positive rod typically found in the soil and not commonly known to be pathogenic. We present a rare case of Agromyces mediolanus bacteremia with aortic valve endocarditis in a patient who required prolonged inpatient care with a tunneled dialysis catheter for renal replacement therapy (RRT). Infection is the second leading cause of mortality among patients with end-stage renal disease and vascular access. The incidence of bacteremia is higher in patients with indwelling tunneled catheters than in those with an arteriovenous fistula or graft. The most critical risk factor is its prolonged use. Anticipation of the need for long-term definitive renal replacement therapy and planning for the best approach is crucial in preventing catheter-related bloodstream infections (CRBSIs). Human infections caused by Agromyces mediolanus are rare; it has been reported twice, and both cases were associated with prolonged use of catheters, not only parenteral catheter but also peritoneal catheter, which is of special importance for patients with end-stage renal disease (ESRD). Limited data is available for the appropriate antibiotic therapy.
Case Report: Novel Biallelic Variants in the COL18A1 Gene in a Chinese Family With Knobloch Syndrome
Authors: Shuk Ching Chong, Yuet-Ping Yuen, Ye Cao, Sze-Shing Fan, Tak Yeung Leung, Emily K Y Chan, Xian Lun Zhu
Journal: Front Neurol (2022)
Keywords: col18a1, knobloch syndrome, case report, collagenopathy, retinal detachment
MeSH terms: Case Reports

Knobloch syndrome is a rare collagenopathy characterized by severe early onset myopia, retinal detachment, and occipital encephalocele with various additional manifestations due to biallelic changes in the COL18A1 gene. Here we reported a Chinese family with two affected siblings presented with antenatal occipital encephalocele, infantile onset retinal detachment, and pronounced high myopia at early childhood. Quartet whole exome sequencing was performed in this family and identified that both siblings carried novel compound heterozygous variants in the COL18A1 gene (NM_001379500.1): the maternally inherited variant c.1222-1G>A at the consensus acceptor splice site of intron 8, and the paternally inherited frameshift variant c.3931_3932delinsT p.(Gly1311Serfs*25) in the last exon. Both patients had successful surgical treatment for the occipital encephalocele soon after birth. They had normal neurocognitive outcome and good general conditions examined at the age of 7 years old for the elder sister and 4 years old for the younger brother. The younger brother developed infantile onset retinal detachment at 7 months of age while the sister had high myopia without signs of retinal detachment until 7 years old. This report expands the phenotype and genotype spectrum of Knobloch syndrome with antenatal and postnatal findings.
Massive thymic hyperplasia in a 15-month-old boy: Case report and literature review
Authors: Elisa Tadiotto, Maria Clemente, Luca Pecoraro, Giorgio Piacentini, Daniela Degani, Angelo Pietrobelli
Journal: Clin Case Rep (2018)
Keywords: computerized tomography scan, pediatric, thymectomy, true thymic hyperplasia
MeSH terms: Case Reports

A surgical approach is the choice in young infants with MTH, who are furthest from the time of physiological involution of the thymus, and when the thymus achieves the largest relative size, a surgical approach is the choice. Steroid therapy has been shown to be ineffective (4, 9, 16, 18-20). No surgical complications have been reported, and the outcome is excellent. Recurrence has been seen in only one case.
Early diagnosis of femoral neck stress fractures may decrease incidence of bilateral progression and surgical interventions: A case report and literature review
Authors: Kruten M Patel, Brian A Handal, William K Payne
Journal: Int J Surg Case Rep (2018)
Keywords: bilateral femoral neck fractures, case report, osteoporosis, stress fractures, vitamin d deficiency

Introduction:
Early intervention in femoral neck stress fractures (FNSFs) can be self- limiting, but they have an insidious presentation. High index of suspicion for an occult fracture is necessary to avoid bilateral progression and/or operative interventions.
Case presentation:
A 83-year-old female, non-athlete, presents with multiple comorbidities and progressive bilateral FNSFs. Initially the patient presented with groin pain and radiographs demonstrated a non-displaced compression type fracture of the right femoral neck without any inciting events. Subsequently, during a post-operative visit of her right hip, a work-up for new onset contralateral groin pain revealed a non-displaced tension type fracture on the left femoral neck. Both FNSFs were treated with percutaneous cannulated screw fixation.
Discussion:
Vitamin D deficiency, poor nutrition, and osteoporosis have been associated with developing stress fractures. This presents an interesting question of whether these frequently referenced risk factors play an interrelated role. Treatment algorithms are controversial, but have been successful in preventing the progression of occult stress fractures. Yet, identification of FNSFs represents a major challenge in diagnosis for clinicians.
Conclusion:
This case report documents an uncommon fracture pattern in the elderly population. With an aging population, it is pertinent to avoid missed opportunities for prompt diagnosis and implementation of noninvasive methods of treatment. Therefore, paying attention to the risk factors with a high index of suspicion would be ideal.
Conservative treatment of a psoas hematoma revealed by a lower limb palsy
Authors: Zidouh Saad, Belkouch Ahmed, Rafai Mostafa, Bakkali Hicham, Belyamani Lahcen
Journal: Pan Afr Med J (2017)
Keywords: palsy, conservative treatment, hematoma
MeSH terms: Conservative Treatment / methods, Hematoma / therapy, Paralysis / etiology, Case Reports, Anticoagulants / administration & dosage, Anticoagulants / adverse effects, Hematoma / chemically induced, Hematoma / diagnosis, Humans, Lower Extremity, Male, Middle Aged, Psoas Muscles / pathology, Anticoagulants

The psoas hematoma is a rare complication of the anticoagulation therapy. It cause abdominal or lumbar pain, muscle dysfunction and sometimes nerve palsy. The optimal treatment is not well established, surgery or conservative treatment? We report here a case of psoas hematoma revealed by a lower limb palsy.
A serious adverse surgical event: Management of suspected HSV-1 keratitis in a donor cornea
Authors: Rebecca Kaye, Bernhard Steger, Jern Y Chen, Vito Romano
Journal: Spektrum Augenheilkd (2017)
Keywords: corneal transplant, donor, herpes simplex (hsv), keratitis, recipient

Purpose:
To describe the management of a serious adverse event in a patient undergoing penetrating keratoplasty (PK).
Case report:
A 68-year-old man underwent PK for an aphakic bullous keratopathy following previous complicated cataract surgery. He had no past history of herpetic disease. Storage of the corneoscleral disc in the transport bottle precluded microscopic examination. After placement of the trephined donor cornea on the open eye of the recipient, a large dendritiform geographic ulcer was noted on the donor cornea. A replacement cornea was used after changing potentially contaminated instruments. Intravenous antiviral treatment was commenced intraoperatively to reduce the risk of infection to the central nervous system. Postoperatively, oral and topical antiviral treatment was commenced and 6 months following surgery the patient developed a geographic corneal ulcer at the graft host interface.
Conclusion:
Containers to transport corneoscleral discs should enable microscopic examination by the surgeon prior to use. High dose systemic antivirals may reduce the risk of herpetic disease involving the posterior segment of the eye and neuroretina in the aphakic eye and spread to the central nervous system.
A useful treatment for patients with advanced mixed-type small cell neuroendocrine carcinoma of the prostate: A case report
Authors: Kei-Ichiro Uemura, Go Nakagawa, Katsuaki Chikui, Fukuko Moriya, Makoto Nakiri, Tokumasa Hayashi, Shigetaka Suekane, Kei Matsuoka
Journal: Oncol Lett (2013)
Keywords: external-beam radiotherapy with intra-arterial chemotherapy, ischuria, locally advanced tumor, prostatic small cell neuroendocrine carcinoma

Treating extended prostatic small cell neuroendocrine carcinoma (PSCNC) is extremely difficult and no standard treatment has yet been established. We experienced a case of advanced mixed-type PSCNC in which the patient achieved long-term survival and local control following combined therapy. Locally advanced PSCNC causing lower urinary obstruction was detected during androgen-ablation therapy for stage D2 mixed adenocarcinoma PSCNC. The patient was treated with intra-arterial infusion chemotherapy using a reservoir system and external-beam radiotherapy (EBRT) to the whole pelvis and local tumor. After chemoradiotherapy, the patient's lower urinary obstruction was reduced and did not return during the remaining 40 months of the patient's life. The patient survived for 70 months following the start of the androgen-ablation therapy. The present study reports a useful treatment for advanced mixed-type PSCNC, androgen-ablation therapy and chemoradiotherapy. The present results also suggest that the prognostic factors for advanced mixed-type PSCNC are the sensitivity of the conventional adenocarcinoma to androgen-ablation therapy, degree of metastasis and extent of the small cell neuroendocrine carcinoma component.
Uretero-iliac artery fistula: a diagnostic and therapeutic challenge
Authors: Muhammad Z Aslam, Ferhad Kheradmund, Nilay Patel, David Cranston
Journal: Adv Urol (2010)
MeSH terms: Case Reports

Uretero-Iliac artery fistulas (UAFs) are very uncommon in urological practice. The rarity of this clinical entity may lead to a delayed or missed diagnosis which can result in life-threatening consequences. We present a case of a right ureteric and right external iliac artery fistula, its presentation, diagnosis, and management along with the review of the literature.
Rare Co-occurrence of Ocular Myasthenia Gravis and Thyroid-Associated Orbitopathy (Ophthalmopathy) in an Individual With Hypothyroidism
Authors: Ran An, Yan Li, Baiyuan Yang, Hui Wang, Yanming Xu
Journal: Front Endocrinol (Lausanne) (2019)
Keywords: graves' disease, tao, hyperthyroidism, hypothyroidism, myasthenia gravis, radioactive iodine therapy, thyroid-associated ophthalmopathy, thyroid-associated orbitopathy
MeSH terms: Case Reports

Ocular myasthenia gravis (Ocular MG, OMG) shares many clinical features with thyroid-associated orbitopathy or thyroid-associated ophthalmopathy (TAO). In the rare instance of their coexistence, clinicians may fail to diagnose ocular MG when TAO is also present. Here we report the case of a patient with both TAO and ocular MG, whose "hyperthyroidism"-most likely the hashitoxicosis variant of Hashimoto's thyroiditis-rapidly transformed to hypothyroidism after radioactive iodine therapy. This is reminiscent of a previous case of a patient with MG, in whom disease onset coincided with the methimazole-induced transformation from hyper- to hypothyroidism. It is possible that the same transformation from "hyper-" to hypothyroidism, which occurred after radioactive iodine therapy and was accompanied by hypothyroidism-associated orbitopathy (ophthalmopathy), may have induced the development of myasthenia gravis in our patient. The hypothyroidism may have been caused by the radioactive iodine therapy and/or it may simply reflect the natural course of the hashitoxicosis variant of Hashimoto's thyroiditis. The co-occurrence of hypothyroidism, hypothyroidism-associated orbitopathy (ophthalmopathy) and ocular MG has never been reported. Our case highlights the need for clinicians to focus on overlapping symptoms of hyperthyroidism and the hashitoxicosis variant of Hashimoto's thyroiditis, and to carefully differentiate between them, especially when deciding on radioactive iodine therapy. In addition, our case highlights that the possible co-occurrence of TAO should be considered when a patient with thyroid disease displays both ptosis and eye movement dysfunction, and when only the ptosis is dramatically resolved after treatment with pyridostigmine bromide.
A Case of Implantable Collamer Lens (ICL) with Reverse Orientation for 10 Years
Authors: Bader S AlQahtani, Abdulaziz A Alshamrani, Raed E Alsulami, Jose M Vargas
Journal: Case Rep Ophthalmol Med (2021)
MeSH terms: Case Reports

Background:
Implantable collamer lens (ICL) might rarely cause complications that warrant explantation. Here, we presented a case of inverted ICL that has undergone explantation after a 10-year duration. Case Presentation. A 49-year-old male with past ocular history of ICL implantation 10 years ago presented complaining of progressive decrease of visual acuity in the left eye for a long time. On examination, decreased visual acuity, anterior subcapsular cataract, and low ICL vault were noted. The anterior segment optical coherence tomography (AS OCT) showed inverted ICL. The ICL was explanted, and cataract surgery was done.
Conclusion:
Inverted ICL should be kept in mind as a rare cause of long-term poor visual acuity in patient with a history of ICL surgery.
A Case Report of Subacute Thyroiditis following mRNA COVID-19 Vaccine
Authors: Leidy Plaza-Enriquez, P Khatiwada, M Sanchez-Valenzuela, A Sikha
Journal: Case Rep Endocrinol (2021)
MeSH terms: Case Reports

Background:
Subacute thyroiditis has been reported after administration of influenza vaccine. We describe a case of a patient who developed subacute thyroiditis after administration of. Moderna mRNA COVID-19 vaccine. Case Presentation. A 42-year-old female, with a past medical history of stage IIIB pT3N1aM0 right adenocarcinoma of colon status, after right hemicolectomy on 01/2020, followed by adjuvant chemotherapy, paroxysmal supraventricular tachycardia, iron deficiency anemia, chemotherapy-induced neuropathy, and lumbar radiculopathy, presented to our clinic with anterior neck pain that started 6 days after the second dose of Moderna mRNA COVID-19 vaccine. She was diagnosed with subacute thyroiditis and treated conservatively with pain medications.
Conclusion:
Subacute thyroiditis could represent one of the side effects of Moderna mRNA COVID-19 vaccine. Further reports are lacking.
A rare case of small-cell neuroendocrine tumour of the lung metastasising to the urinary bladder
Authors: Humphrey Mapuranga, Siseko Silolo, Abraham C van Wyk, Sucari S C Vlok
Journal: SA J Radiol (2023)
Keywords: biopsy, cystoscopy, immunohistochemistry, metastases, small-cell neuroendocrine carcinoma
MeSH terms: Case Reports

A 77-year-old woman with suspected lung carcinoma had multiple bladder masses and lymphadenopathy outside the normal urinary bladder drainage area. Fine needle aspiration and immunocytochemistry of the cervical lymph node complex and transurethral biopsy of the bladder masses confirmed metastatic small-cell neuroendocrine carcinoma.
Contribution:
Clinical correlation, imaging findings, tumour markers and immunohistochemistry are necessary for metastatic bladder tumour work-up.
A case report of postoperative VRSA enteritis: Effective management of rifampicin for vancomycin resistant Staphylococcus aureus enteritis after esophagectomy and colon reconstruction
Authors: Naoya Okada, Takeo Fujita, Jun Kanamori, Ataru Sato, Yasumasa Horikiri, Takuji Sato, Hisashi Fujiwara, Hiroyuki Daiko
Journal: Int J Surg Case Rep (2018)
Keywords: colon reconstruction, enteritis, esophagectomy, rifampicin, vrsa

Introduction:
Vancomycin is one of the most widely used antibiotics for the treatment of serious infectious caused by methicillin-resistant Staphylococcus aureus (MRSA). However, reduced susceptibility of S. aureus to vancomycin has been observed in recent years. We report on a case of vancomycin resistant methicillin-resistant Staphylococcus aureus (VRSA) enteritis after colon reconstruction followed by esophagectomy and completion gastrectomy, with extended lymph node dissection for esophageal squamous cell carcinoma.
Presentation of case:
A 66-year old male was referred to our hospital for esophageal carcinoma of clinical stage T3 N0 M0, Stage IIA. From the postoperative day 3, the patient reported heavy watery stools on more then 10 occasions and high fever, and was diagnosed with the methicillin-resistant Staphylococcus aureus (MRSA) enteritis. We administered vancomycin to treat the enteritis, although a subsequent stool culture indicated VRSA instead of MRSA. Rifampincin treatment was initiated and the patient's symptoms improved.
Discussion:
In this case report, this patient underwent esophagectomy, total resection of the gastric remnant, and colon reconstruction, and it is likely that methicillin-resistant Staphylococcus aureus (MRSA) from the upper airway system, which is not exposed to gastric acid, proliferated in the interposed colon and resulted in MRSA enteritis.
Conclusions:
Rifampicin represents an effective treatment strategy for postoperative VRSA enteritis.
Heterozygous PLA2G6 Mutation Leads to Iron Accumulation Within Basal Ganglia and Parkinson's Disease
Authors: Rosangela Ferese, Simona Scala, Francesca Biagioni, Emiliano Giardina, Stefania Zampatti, Nicola Modugno, Claudio Colonnese, Marianna Storto, Francesco Fornai, Giuseppe Novelli, Stefano Ruggieri, Stefano Gambardella
Journal: Front Neurol (2018)
Keywords: l-dopa responsive, park14, parkinson and iron accumulation, genetic of parkinson's disease, incomplete penetrance
MeSH terms: Case Reports

Mutations of PLA2G6 gene are responsible for PARK14, an autosomal recessive L-DOPA responsive dystonia/parkinsonism with early/adult onset. This phenotype possesses an high clinical variability, which consists in the occurrence of cerebral and cerebellar atrophy, iron accumulation in the basal ganglia, and cognitive decline. This report describes a PD patient carrying an heterozygous PLA2G6 mutation, which was identified also in his PD affected sister. This patient is characterized by a L-DOPA responsive typical parkinsonian syndrome without the occurrence of dystonia, a slight cognitive decline, presence of iron accumulation both in neo and paleostriatum while cerebellar atrophy was absent. Clinical and imaging features are compatible with the PARK14 phenotype. Although PARK14 has been previously reported to be inherited as a recessive disorder, clinical and genetic analysis of this proband and his family rise the hypothesis that even heterozygous PLA2G6 mutations may cause PARK14. It remains to be analyzed whether these heterozygous variants may act as dominant mutations, or they merely increase the risk to develop PD by acting within a context of synergistic genetic and/or environmental backgrounds.
Imaging of a case of extramedullary solitary plasmacytoma of the trachea
Authors: M Garelli, C Righini, C Faure, A Jankowski, C Brambilla, G R Ferretti
Journal: Case Rep Radiol (2011)
MeSH terms: Case Reports

We describe a case of extramedullary tracheal plasmacytoma that was incidentally discovered in a 73-year-old man on a PET scan performed for assessing the extent of colon cancer. CT scan showed the tumor; multiplanar reformation coupled with virtual bronchoscopy allowed proper treatment planning. The tracheal tumor was resected during rigid bronchoscopy. Relevant investigations excluded multiple myeloma. Follow-up CT showed persistent thickening of the tracheal wall, but there has been no recurrence after one-year followup.
Unicentric epithelioid hemangioendothelioma of the calcaneus: a case report and review of literature
Authors: Mark C Plumby, Patrick Bacaj, Brock A Lindsey
Journal: Clin Sarcoma Res (2018)
Keywords: angiosarcoma, epithelioid, hemangioendothelioma, vascular tumor
MeSH terms: Case Reports

Background:
This review of the literature combined with a clinical case will allow the illustration of a favorable outcome of this variable low grade malignancy, display a role for limb salvage surgery with intralesional treatment, and offer a clinical example of epithelioid hemangioendothelioma, a rare malignancy.
Case presentation:
The case report presents a case of solitary epithelioid hemangioendothelioma (EHE) of the calcaneus in a 60-year-old male. Primary vascular tumors of the bone are rare; however, EHE is one of the most common primary malignant vascular tumors to occur in bone. A review of the literature found few cases that involved the calcaneus; those cases found that involved the calcaneus were either part of a multifocal or metastatic disease process. Our case presents a 45-month clinical follow-up of solitary EHE in the calcaneus treated with surgical excision by curettage and cementing.
Conclusion:
This case has clinical follow-up greater than 2 years post-operatively and could be a guide for treatment of a rare disorder with a substantial paucity of literature.
Transnasal marsupialization using endoscopic sinus surgery for treatment of keratocystic odontogenic tumor in maxillary sinus
Authors: Masafumi Ohki
Journal: Case Rep Otolaryngol (2012)

Objective. We report the first utilisation of transnasal marsupialization to treat a keratocystic odontogenic tumor in the maxillary sinus of a 37-year-old man. Case Report. A 37-year-old man presented with a nasal discharge and right odontalgia. Computed tomography revealed an expanding cystic lesion with a calcificated wall containing an impacted tooth in the right maxillary sinus. The diagnosis was keratocystic odontogenic tumor. Transnasal marsupialization was performed using endoscopic sinus surgery to enlarge the maxillary ostium and remove a portion of the cystic wall. Pathological findings included lining squamous epithelium and inflammation. The remaining tumor shrank, becoming free of infection after surgery, without proliferation. Conclusion. Transnasal marsupialization using endoscopic sinus surgery is effective in treating keratocystic odontogenic tumors. It offers minimal surgical invasion and reductive change, making it advantageous for complete removal with fewer complications in the bones and surrounding tissue in the case of secondary surgery.