OpenMed/multicare-articles huggingface dataset:
Diagnosis of acquired generalized lipodystrophy in a single patient with T-cell lymphoma and no exposure to Metreleptin
Authors: Nazanene H Esfandiari, Melvyn Rubenfire, Adam H Neidert, Rita Hench, Abdelwahab Jalal Eldin, Rasimcan Meral, Elif A Oral
Journal: Clin Diabetes Endocrinol (2019)
Keywords: acquired generalized lipodystrophy, diabetes, insulin resistance, leptin, t-cell lymphoma
MeSH terms: Case Reports

Background:
Metreleptin, a recombinant methionyl -human -leptin, was approved to treat patients with generalized lipodystrophy (GL) in February 2014. However, leptin therapy has been associated with the development of lymphoma. We present a unique case of a patient with prior history of T cell lymphoma in remission, who was diagnosed with Acquired Generalized Lipodystrophy (AGL) during the following year after a clinical remission of her lymphoma without receiving leptin therapy.
Case presentation:
A 33-year-old woman with a diagnosis of stage IV subcutaneous panniculitis like T-cell lymphoma in 2011, underwent chemotherapy. Shortly after completion therapy, she had a relapse and required more chemotherapy with complete response, followed by allogenic stem cell transplant on June 28, 2012. Since that time, she has been on observation with no evidence of disease recurrence. Subsequent to the treatment, she was found to have high triglycerides, loss of fat tissue from her entire body and diagnosis of diabetes. Constellation of these findings led to the diagnosis of AGL in 2013. Her leptin level was low at 3.4 ng/mL (182 pmol/mL). She is currently not receiving any treatment with Metreleptin for her AGL.
Conclusions:
Causal association between exogenous leptin therapy and T-cell lymphoma still remains unclear. We hereby present a case of a young woman who was diagnosed with AGL after going into remission from T-cell lymphoma and who has never been treated with Metreleptin. Steroid therapy and chemotherapy might have masked the diagnosis of AGL in this patient. We believe that patients can develop these 2 conditions independent of each other.
Pott's Puffy Tumor, a Forgotten Complication of Sinusitis: Report of Two Cases
Authors: Elnaz Jalali, Anusha Vaddi, Kandasamy Rengasamy, Aditya Tadinada
Journal: Cureus (2023)
Keywords: frontal sinus, frontal sinusitis, hemi pansinusitis, osteomyelitis of frontal bone, pott’s puffy tumor
MeSH terms: Case Reports

Pott's puffy tumor (PPT) is a life-threatening complication of infectious sinusitis/osteomyelitis of the frontal bone. It occurs due to infection or trauma and is often seen in late childhood and adolescence. If left untreated for a protracted period, intracranial complications such as epidural abscess, subdural empyema, meningitis, and a cerebral abscess may occur. The diagnosis is often confirmed with CT. Prompt medical and surgical treatment is mandatory as there is the potential for significant morbidity if not quickly diagnosed and treated. This paper presents two cases of PPT manifested in patients with hemi pansinusitis.
Squamous Cell Carcinoma of the Thyroid as a Result of Anaplastic Transformation from BRAF-Positive Papillary Thyroid Cancer
Authors: Alina Basnet, Aakriti Pandita, Joseph Fullmer, Abirami Sivapiragasam
Journal: Case Rep Oncol Med (2017)
MeSH terms: Case Reports

Papillary thyroid carcinoma (PTC) is the most common malignant neoplasm of the thyroid. Majority of the PTC carries an excellent prognosis. However, patients with tall cell variant (TCV) of papillary thyroid carcinoma have a worse prognosis than those with the classic variant. On the other hand, squamous cell carcinoma of the thyroid (SCT) is an unusual neoplasm thought to arise as a primary tumor or as a component of an anaplastic or undifferentiated carcinoma. We report a patient with TCV of PTC presenting years later with squamous transformation. In addition, the patient was found to have BRAF mutation. Such dedifferentiation is considered to be a rare phenomenon and has been reported only in the form of case reports in the literature. The relationship between BRAFV600E mutation and squamous cell transformation of papillary thyroid cancer is unknown at this time. Meticulous pathology is needed to identify such variants. Our patient responded to treatment with concurrent chemotherapy with carboplatin and paclitaxel along with radiation.
The Community Health Experience Model-value generation from person-centered health transaction network
Authors: Zoltán Lantos, Judit Simon
Journal: Public Health Rev (2018)
Keywords: co-creation, health experience, medication management, person-centeredness, value-based healthcare

Background:
Network society is creating new opportunities for value generation in all areas of our lives: new collaborative methods and tools are increasingly available for use by closely connected individuals and organizations. The stakeholders of the health ecosystem are potential winners of this networking process as a consequence of the increase in knowledge about health value generation supported by teamwork and collaborative approaches in this field.
Case presentation:
In this paper, we focus on the transactional nature of health value generation networks. First, we analyze the transactions in the networks. We then propose a design structure-the Community Health Experience Model-for effective person-centered health value generation networks. In the second phase of the work, we describe how the system design of the complete transaction network was tested in a real-life pilot environment focusing on fall prevention in individuals with osteoporosis.As a result of the network-based collaborative service approach, fall risk decreased by 11.8% and the number of falls decreased by 4.5% within 3 months. Regarding the major health experience outcomes, self-evaluated condition-specific health literacy improved from 7.85 to 8.26 (an improvement of 0.41), while self-evaluated condition-specific self-management capability changed from 7.25 to 8.06 (0.81 improvement).
Conclusions:
In conclusion, the proposed Community Health Experience Model is a novel and promising approach to designing the structure of more effective and efficient health services and collaborative networks.
Transient Neonatal Diabetes Mellitus in SHORT Syndrome: A Case Report
Authors: Shin-Hee Kim, Minsung Kim, Jisook Yim, Myungshin Kim, Dae-Hyun Jang
Journal: Front Pediatr (2021)
Keywords: pik3r1 gene, short syndrome, dysmorphic feature, insulin resistance, transient neonatal diabetes mellitus
MeSH terms: Case Reports

SHORT syndrome is a rare autosomal dominant disorder characterized by multiple congenital defects and is historically defined by its acronym: short stature, hyperextensibility of joints and/or inguinal hernia, ocular depression, Rieger anomaly, and teething delay. Herein, we report a male infant with SHORT syndrome who presented with transient neonatal diabetes mellitus (TNDM) with insulin resistance. The proband was born at 38 weeks of gestation but displayed facial dysmorphic features. Intrauterine growth restriction (IUGR) was detected on a prenatal ultrasonography test. His birth weight was 1.8 kg (<3rd percentile), length 44 cm (<3rd percentile), and head circumference 31 cm (<3rd percentile). The patient's blood glucose level started to increase at 5 days of age (218-263 mg/dl) and remained high at 20 days of age (205-260 mg/dl). He was treated with subcutaneous insulin and the blood glucose level gradually stabilized. Blood glucose level was stabilized over time without insulin treatment at 6 weeks of age. Clinical exome sequencing showed a heterozygous pathogenic variant, NM_181523.3:c.1945C>T (p.Arg649Trp) in exon 15 of the phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) known as the causative gene for SHORT syndrome. Examination of the patient at 10 months of age revealed no hyperglycemic episode and glycated hemoglobin level was 5.2%. To the best of our knowledge, this is the first case of TNDM in SHORT syndrome due to a pathogenic variant of PIK3R1. We believe that our case can aid in expanding the phenotypes of SHORT syndrome.
Myocardial Infarction after Endoscopic Removal of Foreign Body
Authors: Carola Maraboto, Florentino Lupercio, Ileana L Piña
Journal: Case Rep Cardiol (2017)
MeSH terms: Case Reports

The development of cardiac complications during or after endoscopic procedures is rare. However, mortality from myocardial ischemia, particularly in the elderly population, is elevated. We illustrate the rare case of a 79-year-old man with multiple cardiovascular risk factors who developed a non-ST elevation myocardial infarction (NSTEMI) after endoscopic removal of a foreign body. This case report summarizes a rare complication of a low-risk procedure and highlights the importance of considering this potential adverse event, particularly in patients with significant cardiovascular risk factors, to promote early diagnosis and proper treatment.
Hydrogen peroxide poisoning: an unusual cause of portal venous gas
Authors: Evyn Arnfield, Hemant Bhardwaj, Nicholas Brown, Michael Handy, Perry Cleland
Journal: BJR Case Rep (2016)
MeSH terms: Case Reports

Hydrogen peroxide (H2O2) is an oxidizing agent found in many household products. It is a clear liquid at room temperature, allowing it to be mistaken for water if unlabelled. Ingestion of H2O2 can have serious sequelae even in low volumes and concentrations.We present a case study of H2O2 poisoning and discuss the pertinent radiographical findings.
Case report: A hybrid technique for a safe nephrectomy in a giant kidney angiomyolipoma
Authors: Vincenzo Vento, Andrea Benedetto Galosi, Andrea Ranghino, Luca Montecchiani, Luca Felici, Silvia Loggi, Elisabetta Cerutti, Giulio Milanese, Carmine Franzese, Daniele Castellani, Emanuele Gatta
Journal: Front Surg (2022)
Keywords: angiomyolipoma, endovascular procedures, nephrectomy, rare diseases, tuberous sclerosis
MeSH terms: Case Reports

Background:
Giant angiomyolipoma is usually associated with genetic syndromes and complications (spontaneous rupture and bleeding, hematuria, hypertension) and mass-related symptoms (flank and abdominal pain).
Case presentation:
We present a case of a 20-year-old woman suffering from tuberous sclerosis who was referred to our hospital with a giant angiomyolipoma causing abdominal pain. A contrast-enhanced computed tomography showed a left angiomyolipoma, measuring 28 cm × 17 cm × 27 cm. After a multidisciplinary team discussion, the patient was submitted for a nephrectomy. Percutaneous temporary occlusion of the main renal artery was achieved through an endovascular balloon catheter. Through the balloon catheter guidewire, 2,500 IU of heparin was infused to reduce the risk of tumor vein thrombosis and venous embolism. This allowed a safe kidney manipulation through a left thoracoabdominal approach. The postoperative course was uneventful. Pathology showed a 40 cm × 30 cm × 9 cm and 10 kg AML. One year after surgery, the patient is on follow-up, and her estimated glomerular filtration is 120.5 ml/min/1.73 m2.
Conclusion:
The present case showed that the endovascular control of the main renal artery could be considered a useful approach to safely managing huge renal masses when renal hilar control is expected to be very difficult.
Fabrication of customized sectional impression trays in management of patients with limited mouth opening: a simple and unique approach
Authors: Vamsi Krishna Ch, K Mahendranadh Reddy, Nidhi Gupta, Y Mahadev Shastry, N Chandra Sekhar, Venkat Aditya, G V K Mohan Reddy
Journal: Case Rep Dent (2013)

Impression making is not only important but is also the most significant step in the fabrication of any fixed or removable prosthesis. Proper impression making may be hindered by certain pathologic conditions. Reduced mouth opening is one of the common mechanical obstructions for proper orientation of the impression tray in the patient's mouth. In patients with trismus induced by submucous fibrosis, the procedure may be even more difficult to carry out because of reduced tissue resiliency and obliteration of vestibular spaces. Use of sectional trays offers one of the alternatives to overcome the problem of restricted mouth opening. Fabrication of customized impression trays according to the patient dentition improves the accuracy of impression making. The present case reports describe the fabrication of sectional custom trays designed for dentulous patients with chronic tobacco-induced submucous fibrosis.
Endodontic management of mandibular first molar with middle distal canal: a case report
Authors: Vijay Reddy Venumuddala, M Sridhar, M Rajasekaran, Saravanan Poorni, Gnanaprakasam Senthilkumaran
Journal: Case Rep Dent (2012)
MeSH terms: Case Reports

The knowledge of variations in root canal morphology is critical for a successful endodontic treatment. This article presents the endodontic management of a unique case of mandibular molar with middle distal canal which is quite uncommon.
Agenesis of multiple primary teeth and
Authors: Svsg Nirmala, Niraj Gokhale, N Sivakumar, Md Akhil Quadar
Journal: Int J Clin Pediatr Dent (2013)
Keywords: agenesis, nonsyndromic, oligodontia, primary dentition
MeSH terms: Case Reports

Agenesis of multiple primary teeth is rare. A 6-year-old girl visited our department, in the absence of any other systemic abnormalities, on clinical and radiographic evaluation, it was revealed that she had only 6 primary teeth in her mouth. Maxillary and mandibular removable partial dentures were fabricated for prosthodontic rehabilitation. At the 6 months follow-up nutrition of the patient as well as self-confident appearance was improved. How to cite this article: Nirmala SVSG, Gokhale N, Sivakumar N, Quadar MA. Agenesis of Multiple Primary Teeth and Its Rehabilitation: A Case Report. Int J Clin Pediatr Dent 2013; 6(1):55-57.
Uterine perivascular epithelioid tumors (PEComas) with lung metastasis showed good responses to mTOR and VEGFR inhibitors: A case report
Authors: Chengxu Sui, Jie Wu, Dan Mei, Evenki Pan, Peng Yang, Tingting Wu, Yutong Ma, Qiuxiang Ou, Lei Song
Journal: Front Oncol (2022)
Keywords: tsc2, apatinib, everolimus, lung metastasis, uterine pecoma
MeSH terms: Case Reports

Perivascular epithelioid cell tumors (PEComas) are extremely rare mesenchymal neoplasms for which the uterus is the most common site. The prognosis of malignant PEComa is poor as it is characterized by resistance to classical chemotherapies. Both mTOR inhibitors and VEGFR inhibitors exhibited clinical utility in treating malignant PEComas, but the combination of these two regimens has rarely been reported. In the present case, a uterine PEComa patient developed lung and bone metastases after the failure of chemotherapies and derived benefit from the combination regimen of an mTOR inhibitor (everolimus) and a VEGFR inhibitor (apatinib), achieving a 15-month progression-free survival. Targeted NGS revealed TP53 and TSC2 mutations in the patient's primary uterine tumors and plasma ctDNA at disease progression. Plasma ctDNA clearance was consistent with a radiologic partial response determined by RECIST 1.1 and a reduction of neuron-specific enolase (NSE) and cancer antigen 125 (CA125) levels. Thus, we provided clinical evidence supporting the administration of combined therapy of mTOR and VEGFR inhibitors to metastatic uterine PEComa patients and highlighted the application of serial plasma ctDNA profiling for dynamic disease monitoring.
A CT-FFR-guided unroofing procedure for repairing the anomalous origin of the left coronary artery-a case report
Authors: Hairun Zuo, Chengyi Xu, Li Wang, Chengwei Liu, Li Liu, Xi Su
Journal: Front Cardiovasc Med (2023)
Keywords: anomalous aortic origin of a coronary artery, computed tomography angiography, fractional flow reserve, sudden cardiac death, unroofing procedure
MeSH terms: Case Reports

Anomalous aortic origin of a coronary artery (AAOCA) is a congenital malformation of the coronary arteries that includes several subtypes. It is a leading cause of sudden cardiac death in young people, especially in competitive athletes. An accurate diagnosis and identification of high-risk patients with AAOCA for referral for surgical repair can help in the management of these patients. However, current diagnostic tools such as invasive angiography, echocardiography, and intravascular ultrasound have known limitations in visualizing coronary orifices and characterizing vessels. In this case report, we report on a 14-year-old adolescent who suffered from repeated incidents of syncope during exercise. Using the computed tomographic fractional flow reserve (CT-FFR) technique, we diagnosed AAOCA, which revealed that his left coronary artery (LCA) originated from the right sinus of Valsalva and ran between the aorta and the pulmonary artery with an intra-arterial wall course (∼20 mm in length), with an abnormal FFR of the LCA at rest. The patient was referred for undergoing unroofing surgery, and the results of repeat CT-FFR showed a significantly improved FFR of the LCA. The patient resumed his normal physical activities without the recurrence of syncope. In this report, we highlight the usefulness of CT-FFR as a non-invasive, feasible, and effective tool to guide whether a patient with AAOCA requires surgical revascularization and to evaluate the effectiveness of the procedure after surgery.
Osteomyelitis of the Patella in a 10-Year-Old Girl: A Case Report and Review of the Literature
Authors: Matthias Sperl, Michael Novak, Daniela Sperl, Martin Svehlik, Georg Singer, Tanja Kraus
Journal: Case Rep Orthop (2017)
MeSH terms: Case Reports

The incidence of osteomyelitis constantly declines. While the disease most commonly affects the long bones, involvement of the patella is rarely seen. Due to this rarity and the variable clinical presentation, diagnosis is often delayed. The present case report describes a 10-year-old female patient with a delayed diagnosis of patella osteomyelitis. The diagnostic procedures and the treatment regimen are described. Additionally, a detailed literature review of the available publications reporting osteomyelitis of the patella in children is presented.
Heart failure monitoring with a cardiac resynchronization therapy device-based cardiac contractility sensor: a case series
Authors: Jacques Mansourati, Mélanie Heurteau, Jérôme Abaléa
Journal: J Med Case Rep (2014)

Introduction:
The SonR signal has been shown to reflect cardiac contractility. It is recorded with an atrial lead connected to a cardiac resynchronization therapy defibrillator. For the first time, clinical evidence on the use of the SonR signal in the monitoring of the clinical status of heart failure patients implanted with cardiac resynchronization therapy defibrillator are presented through three clinical cases.
Case presentation:
In the two first patients (non-Hispanic/Latino white), the SonR amplitude increases concomitantly to clinical status improvement subsequent to cardiac resynchronization therapy defibrillator implantation. In the third patient (non-Hispanic/Latino white), a decrease in SonR amplitude is observed concomitantly to atrial fibrillation and clinical status deterioration.
Conclusions:
This case series reports the association between SonR signal amplitude changes and patients' clinical status. Combined with remote monitoring, early SonR signal amplitude remote monitoring could be a promising tool for heart failure patients' management.
Subjective Well-Being of Professional Females: A Case Study of Dalian High-Tech Industrial Zone
Authors: Yuqing Zhang, Ya Gao, Chengcheng Zhan, Tianbao Liu, Xueming Li
Journal: Front Psychol (2022)
Keywords: emotional cognition, extra-household life, intra-household life, life satisfaction, professional females

The education level and social participation of contemporary Chinese women have reached their historical peak; work is fast becoming the dominant theme of their lives. However, influenced by traditional attitudes, women are still expected to undertake the main family care tasks, thus, facing dual constraints of family and work, which seriously affect their life happiness. Based on the theory of subjective well-being and feminist geography, this study used the questionnaire survey and in-depth interview results of professional females in Dalian High-tech Industrial Zone as basic data to explore the life satisfaction and emotional cognition in intra- and extra-household life of professional females (Professional females: In this study, they are the women who have received formal education and currently have full-time and steady job (including regular employees in the national systems and those who have signed labor contracts with labor units).). The following results were obtained: (1) Most professional females reported higher life satisfaction in intra- rather than extra-household life, and it varied with individual attributes, reflecting the internal differences among them. (2) The positive emotions of professional females came from the company of family and friends in intra-household life, and satisfaction with the working environment and treatment in extra-household life. (3) The negative emotions came from the pressure of "marriage," "birth," and other traditional concepts in intra-household life. In extra-household life, it came from the health problems caused by working stress, interpersonal problems and gender inequality in the workplace, and the anxiety of age and future career development. Therefore, this study committed to revealing the living status and subjective feelings of contemporary professional females in China, hoping to improve women's life quality and enhance their life happiness from a theoretical and realistic perspective.
Surgical treatment of a symptomatic os acromiale by arthroscopy-assisted double-button fixation: a case report
Authors: Larissa Eckl, Markus Scheibel
Journal: Arch Orthop Trauma Surg (2023)
Keywords: acromion, arthroscopy, case report, double-button fixation, shoulder
MeSH terms: Acromion / diagnostic imaging, Acromion / surgery, Arthroscopy, Case Reports, Female, Humans, Middle Aged, Neurosurgical Procedures

Case:
We present the case of a symptomatic os acromiale in a 51-year-old female patient. Arthroscopy-assisted treatment was performed using a double-button fixation system and additional suture cerclage. The patient presented with complete radiographic bone union, pain relief, improved range of motion and did not require hardware removal at the 12-month follow-up.
Conclusion:
The achievement of persistent consolidation between the two fragmented bone surfaces, without further need for hardware removal and improved clinical outcome, suggests that our minimally invasive technique is appropriate for this specific indication. To our knowledge, this technique has not been described in the literature yet.
Budd-Chiari syndrome due to right hepatic lobe herniation: CT image findings of two rare clinical conditions
Authors: Shyamal Saujani, Safi Rahman, Bruce Fox
Journal: BJR Case Rep (2017)
MeSH terms: Case Reports

Hepatic herniation is a rare clinical condition. Most commonly it is associated with congenital diaphragmatic herniation or acquired through blunt diaphragmatic trauma. We present a case of a right hepatic lobe incisional hernia in a 75-year-old female who underwent partial right-sided nephrectomy 52 years previously. Evidence of partial Budd-Chiari syndrome was seen on CT scan that was presumed to be as a result of traction of the herniated liver. As far as we are aware this is the first case of a right-sided hepatic hernia with evidence of partial Budd-Chiari syndrome. The patient was treated conservatively with anticoagulation and analgesia.