OpenMed/multicare-articles huggingface dataset:
Hook worm caused chronic anemia found during the procedure of acute gastrointestinal bleeding: a case report
Authors: Yuan Zhao, Liangjing Wang, Jianmin Si
Journal: Cases J (2009)

Background:
Upper gastrointestinal bleeding with complicated factors is always difficult to find the primary origin.
Case presentation:
Here we present a case of a 74-year-old male farmer suffered from acute upper gastrointestinal bleeding caused by gastric ulcer and Mallory-Weiss syndrome and chronic anemia which was at last found caused by hook worm infection.
Conclusion:
It tells us that considering multi-possibility when can not explain the symptom with monophyletism is very important for clinicians.
Congenital Afibrinogenemia presenting as antenatal intracranial bleed: a case report
Authors: Gopakumar Hariharan, Sivji Ramachandran, Rajiv Parapurath
Journal: Ital J Pediatr (2010)
MeSH terms: Afibrinogenemia / diagnosis, Fibrinogen / metabolism, Intracranial Hemorrhages / etiology, Case Reports, Afibrinogenemia / complications, Afibrinogenemia / congenital, Diagnosis, Differential, Female, Humans, Infant, Newborn, Intracranial Hemorrhages / blood, Intracranial Hemorrhages / diagnosis, Magnetic Resonance Imaging / methods, Tomography, X-Ray Computed, Fibrinogen

Congenital afibrinogenemia is a very rare inherited coagulation disorder, characterized by virtual absence of plasma fibrinogen (factor I). There are only about 250 cases reported in the world literature 1. We describe a case of congenital afibrinogenemia which presented as an antenatally detected intracranial bleed.
Case Report: Acute Splenic Artery Thrombosis in a COVID 19, Postpartum Patient
Authors: Sebastian Daniel Trancǎ, Oana Antal, Anca Daniela Farcaş
Journal: Front Med (Lausanne) (2021)
Keywords: covid 19 complications, case report, post-partum, splenic artery thrombosis, splenic infarction
MeSH terms: Case Reports

The incidence of thromboembolic disease is reported to be high in SARS-CoV2 disease. Pregnancy, an already physiologically hypercoagulable state, associated to COVID 19, generates even more concern regarding the potentially increased risk of thrombotic events. The exact incidence of such complications is yet unknown, but there is data suggesting that coagulopathy and thromboembolism are both increased in pregnancies affected by COVID-19. Since the outbreak of the COVID 19 pandemics, the most common described thrombotic events associated with SARS-COV2 infection have been venous thromboembolism and disseminated intravascular coagulation, while arterial thrombotic events are less commonly described. Splenic infarction is a rare disorder that can be secondary to a hypercoagulable state. There are only few cases of splenic infraction described, but none with splenic artery thrombosis, in a post-partum patient, on therapeutic anticoagulation regimen. We present the case of a 31-year-old Caucasian, 26 weeks pregnant woman, with no prior medical history, admitted to the hospital with a severe form of COVID 19 pneumonia and who, during the course of the disease, developed a massive splenic infarction with splenic artery thrombosis.
Adenomatoid Odontogenic Tumor Associated with an Impacted Maxillary Lateral Incisor: A Case Report with Five-Year Follow-Up
Authors: Najwa Karam Genno, Nicole Aoun, Sami El Toum
Journal: Case Rep Dent (2017)
MeSH terms: Case Reports

Adenomatoid odontogenic tumor (AOT), a benign (hamartomatous) lesion of odontogenic origin, is an uncommon tumor which affects mainly females in the second decade. This lesion is most commonly associated with an impacted maxillary canine. This paper reported a case of AOT, in a 16-year-old female, associated with an impacted maxillary left lateral incisor. The evolution of this tumor was followed over 36 months and 24 months after excision.
Case report: A giant bilateral inguinal hernia requiring artificial mesh and multi-stage surgery in infancy; hernioplasty with silo placement to prevent acute compartment syndrome
Authors: Yoichi Nakagawa, Satoshi Makita, Hiroo Uchida, Akinari Hinoki, Chiyoe Shirota, Wataru Sumida, Hizuru Amano, Masamune Okamoto, Aitaro Takimoto, Akihiro Yasui, Seiya Ogata, Shunya Takada, Daiki Kato, Yousuke Gohda, Guo Yaohui
Journal: Front Pediatr (2022)
Keywords: abdominal compartment syndrome, infants, inguinal hernia, muti-stage surgery, silo placement
MeSH terms: Case Reports

Hernioplasty for giant inguinal hernias can cause abdominal compartment syndrome (ACS) in adults but rarely does in infants. We encountered a case of a giant bilateral inguinal hernia in infancy complicated by ACS after hernioplasty. Silo placement via a skin incision effectively treated ACS, after which the abdominal wall was safely closed. Hernioplasty performed early in the clinical course can help expand the abdominal cavity and avoid ACS. Thus, hernioplasty should be performed earlier if the hernia size in the flank space gradually increases.
Primary synovial sarcoma of the thyroid gland: a CARE compliant case report and literature review
Authors: Chutong Ren, Yashan Li, Jiangsheng Huang, Sushun Liu, Zhexu Cao, Qin Jiang, Xiang Lin, Fei Ye, Yi Gong
Journal: Front Med (Lausanne) (2023)
Keywords: ss18 gene, case report, literature review, perioperative evaluation, primary synovial sarcoma of the thyroid gland
MeSH terms: Case Reports

Rationale:
Synovial sarcoma is a subtype of soft tissue sarcoma. Synovial sarcoma in the head and neck region is relatively unusual. Primary synovial sarcoma of the thyroid gland (PSST) is first reported in 2003 by Inako Kikuchi. PSST is extremely rare with only 15 cases documented globally. PSST shows rapid disease progression and a relatively poor prognosis. However, diagnosis and therapy are challenging for clinical surgeons. In this article, we reported the 16th PSST case and reviewed the PSST cases globally for further clinical application.
Patient concerns:
The patient was referred to us because of gradually worsened dyspnea and dysphagia for 20 days. Physical examination showed a 5 × 4 cm mass with a clear boundary and good mobility. Contrast-enhanced ultrasonography (CEUS) and computed tomography (CT) showed a mass in the isthmus of the thyroid gland. The imageology diagnosis tends to be a benign thyroid nodule.
Diagnosis:
After surgery, histopathology, immunohistochemistry, and fluorescence, in situ hybridization indicated the mass to be primary synovial sarcoma of the thyroid gland with no local and distant metastasis.
Interventions:
The patient underwent total thyroidectomy and dissected the lymph nodes in the central compartment. This patient received postoperative chemotherapy (a combination of ifosfamide and epirubicin for five cycles). Patients tolerated chemotherapy well. No recurrence was found during the 9-month follow-up.
Lessons:
Although PSST is an extremely rare disease, we should raise our awareness when we encounter a rapidly growing, cystic-solid mixed thyroid mass with neck compression symptoms to avoid misdiagnosis. Intraoperatively, surgeons should refine surgical procedures to avoid capsular rupture and tumor local implantation metastasis. Intraoperative frozen section pathology is necessary sometimes, especially when the diagnosis could not be established before surgery.
Pedunculated angiomyofibroblastoma of the vulva: case report and review of the literature
Authors: Luca Giannella, Matteo Costantini, Kabala Mfuta, Alberto Cavazza, Lillo Bruno Cerami, Giorgio Gardini, Fausto Boselli
Journal: Case Rep Med (2011)
MeSH terms: Case Reports

Angiomyofibroblastoma (AMFB) is a rare benign mesenchymal tumour that occurs almost exclusively in the vulvovaginal region of women but can also occur occasionally in the inguinoscrotal region of men. It is a well-circumscribed lesion that clinically is often thought to represent a Bartholin's gland cyst and usually does not form a pedunculated mass. To our knowledge, only five cases of vulvar AMFB with pedunculated mass have been reported in the English literature and all cases involving the labia majora and middle-aged women. We report the first case of pedunculated AMFB of the vulva occurring in a young woman of 21 years old and involving the left labia minora. After excluding the most common diseases, pedunculated AMFB should be part of differential diagnosis in the workup of any pedunculated vulvar mass even in young women with a lesion involving the labia minora. We reviewed the literature and summarized all reported cases.
Administration of Immunoglobulins in SARS-CoV-2-Positive Patient Is Associated With Fast Clinical and Radiological Healing: Case Report
Authors: Novella Carannante, Giuseppe Fiorentino, Antonio Corcione, Raffaele Di Sarno, Micaela Spatarella, Nicola Maturo, Fiorentino Fragranza, Pierpaolo Di Micco
Journal: Front Med (Lausanne) (2020)
Keywords: covid 19, pentaglobin, sars-cov2, case report, immunoglobulin, pneumonia
MeSH terms: Case Reports

Polyclonal preparation of IgM as an adjuvant therapy has been reported as a relevant immunomodulant therapy in several infectious diseases, exhibiting, in most cases, improvement of the clinical course. No drug has demonstrated therapeutic efficacy for COVID-19. Immunomodulatory treatment with hydroxychloroquine and biologics as tocilizumab, in fact, has not proven to show satisfactory results in several reports. We therefore treated a selected patient with interstitial multifocal pneumonia, positive to COVID-19, with polyclonal preparation of immunoglobulins as an adjuvant therapy, obtaining in few days clinical remission and improvements in radiological findings. Based on this case report, we suggest that clinical trials are conducted to test the efficacy and safety of polyclonal immunoglobulins for adjunctive therapy of COVID-19.
Case Report: Pulmonary Metastases From Epithelioid Sarcoma in Extremity Favourably Responding to Immunotherapy With Camrelizumab
Authors: Tao-Jun Gong, Fan Tang, Chuan-Xi Zheng, Jie Wang, Yi-Tian Wang, Ya-Han Zhang, Yi Luo, Yong Zhou, Li Min, Chong-Qi Tu
Journal: Front Oncol (2021)
Keywords: pd-l1, epithelioid sarcoma, immune checkpoint inhibitor, pulmonary metastases, tumour immune microenvironment
MeSH terms: Case Reports

Epithelioid sarcoma (ES) is a rare soft tissue sarcoma (STS), with limited therapies available for metastatic disease. Here, we describe a case of a 30-year-old male with ES of the left knee and underwent surgery and radiation therapy for the primary disease. After 2 years, he had local recurrence and underwent extensive resection surgery; however, adjuvant chemotherapies were delayed due to recurrent wound infection. Nine months after the second surgery, progressive disease was confirmed after detection of metastases to the lungs and inguinal lymph nodes. Amputation was performed for the local recurrence, followed by inguinal lymph nodes dissection. Pazopanib was transiently administered but discontinued as a result of wound dehiscence. The tumour specimens were detected with unexpected high level of PD-L1 expression and tumoural infiltrating lymphocytes. Subsequently, he received camrelizumab 2.0 mg/kg every 21 days for 18 cycles with rapid remission of the pulmonary metastases. This promising response to camrelizumab indicates that immunotherapies may be an alternative choice for patients with metastatic ES in lung based on analysing the tumour immune microenvironment.
Secondary primary tumor mimicking osteoradionecrosis
Authors: Giovanna Lopes Carvalho, Daniele Heguedusch, Antônio Cássio Assis Pellizzon, Renan Bezerra Lira, Fábio Abreu Alves, Graziella Chagas Jaguar
Journal: Autops Case Rep (2022)
Keywords: nasopharyngeal carcinoma, case reports, osteoradionecrosis, second primary neoplasms, squamous cell carcinoma of head and neck

Nasopharyngeal carcinoma (NPC) is a malignant tumor rarely found in the head and neck, representing about 1% of all malignancies. The main treatment for NPC is radiation therapy, which is often given in combination with chemotherapy. However, such treatment may lead to long-term complications, including second primary tumors (SPTs) and osteoradionecrosis (ORN). Both complications have similar radiological characteristics, which can lead to erroneous diagnoses. This paper describes a case of a second primary tumor in a patient after 20 years of radiotherapy in the area where a previous extraction was performed, mimicking an osteoradionecrosis process.
Malaria and COVID-19 coinfection in a non-malaria-endemic area in Brazil
Authors: Verônica Diniz Rocha, Larissa W Brasil, Erika de Oliveira Gomes, Ricardo Khouri, Gilcivaldo de Jesus Ferreira, Beatriz Vasconcelos, Marcela de Sá Gouveia, Thais Souza Santos, Mitermayer G Reis, Marcus Vinícius Guimarães Lacerda
Journal: Rev Soc Bras Med Trop (2023)
MeSH terms: COVID-19, Coinfection, Malaria, Case Reports, Adult, Brazil, Diagnosis, Differential, Female, Humans, SARS-CoV-2

Differential diagnosis of coronavirus disease 2019 (COVID-19) from other febrile diseases is one of several challenges imposed by the pandemic. We present a case of severe malaria and COVID-19 coinfection in a non-malaria-endemic region. A 44-year-old female with malaise, fever, hypotension, jaundice, and enlarged liver and spleen was admitted to the intensive care unit. Reverse transcription-quantitative PCR results for severe acute respiratory syndrome coronavirus 2 were positive. Rapid tests, microscopy, and quantitative PCR were positive for Plasmodium vivax. Cytokine storm profiles were identified. We could not determine whether the severe vivax malaria in our patient was triggered by COVID-19 coinfection.
Beneficial Effects of GLP-1 Agonist in a Male With Compulsive Food-Related Behavior Associated With Autism
Authors: Anna Järvinen, Merja K Laine, Roope Tikkanen, Maija L Castrén
Journal: Front Psychiatry (2019)
Keywords: autism, glucagon-like peptide-1 agonist, intellectual disability, obsessive-compulsive disorder, overeating, weight
MeSH terms: Case Reports

Individuals with autism spectrum disorder (ASD) frequently display intensely repetitive, restricted thoughts, and behaviors. These behaviors have similarities to compulsions and/or obsessions in obsessive compulsive disorder (OCD) and are primarily treated with behaviourally-based interventions and serotonin uptake inhibitors (SSRIs). Due to the lack of treatment responses in many cases, however, new treatments are being sought. Here we report beneficial effects of treatment with liraglutide, a glucagon-like peptide-1 (GLP-1) analog, on severe obsessive food craving, binge eating, weight gain, and behavioral problems in an adolescent male with infantile autism and moderate intellectual impairment. Liraglutide treatment reduced weight and unwanted behavior seemingly by preventing food-related repetitive thoughts and compulsions. Our report provides clinical evidence that GLP-1 signaling pathway may represent a novel target for treating food-related behavioral problems and aggressive behavior in ASD.
Bridge Plate Failure with Extensor Tendon Injury: A Case Report and Literature Review
Authors: Rachel Lefebvre, Jessica Intravia, Lisa Cao, Alidad Ghiassi, Milan Stevanovic
Journal: Case Rep Orthop (2018)
MeSH terms: Case Reports

Background:
Dorsal spanning plate fixation is an increasingly popular method of fixation for certain distal radius fractures. Published outcomes are encouraging, but complications are still reported.
Methods:
We present a case report of a 26-year-old woman with spanning plate breakage and extensor pollicis longus (EPL) metallosis, fraying, and near-complete rupture. The patient's unsuccessful follow-up led to this complication. Metallosis and damage to the extensor indices (EI) and distal extensor carpi radialis longus (ECRL) were intraoperative obstacles for tendon transfer to restore EPL function.
Results:
Tendon transfer in the setting of bridge plate failure has not yet been described in the literature. There are reports of spanning plate failure indicating that breakage often happens through the plate's holes and after fracture healing.
Conclusions:
The compounded complication of plate failure with extensor tendon injury emphasizes the important relationship between the local anatomy, barriers to patient care, and potential problems after spanning plate fixation.
A Rare Case of Plasma Cell Gingivitis with Cheilitis
Authors: Yashodeep Chauhan, Shaleen Khetarpal, Madhu Singh Ratre, Manish Varma
Journal: Case Rep Dent (2019)
MeSH terms: Case Reports

Background:
Plasma cell gingivitis (PCG) is a rare condition of the gingiva, characterized histopathologically by infiltration of plasma cells in connective tissue. Hypersensitivity reaction due to antigen is considered as primary etiological factor.
Case presentation:
The present case is of an 18-year-old male patient suffering from gingival enlargement along with cheilitis. Histopathological and immunohistochemistry of tissue revealed lesion as plasma cell gingivitis. After gingivectomy, the follow up of the patient was done for 8 months. Gradual reduction of lip swelling was observed after gingivectomy during subsequent visits.
Conclusion:
Early diagnosis is essential as plasma cell gingivitis has similar pathologic changes seen clinically as in leukemia, multiple myeloma, discoid lupus erythematosus, atrophic lichen planus, desquamative gingivitis, or cicatricial pemphigoid which must be differentiated through hematologic examination.
Pneumorrhachis: An uncommon radiological entity
Authors: Atish Vanmali, Kamlesh D Daji
Journal: SA J Radiol (2021)
Keywords: epidural air, pnuemorrhachis, spontaneous pneumomediastinum
MeSH terms: Case Reports

Pneumorrhachis (PR) is a rare and interesting phenomenon, in which air is present within the spinal canal. The aetiologies are varied, broadly grouped as traumatic, non-traumatic or iatrogenic. Pneumorrhachis secondary to spontaneous pneumomediastinum (SPM) and barotrauma of the lungs is uncommon and even rarer within the paediatric group. This report describes a paediatric patient presenting with a persistent cough who developed a SPM and subsequent PR.
Brown syndrome with severe amblyopia: a case report from Africa
Authors: Bolutife Ayokunnu Olusanya
Journal: Pan Afr Med J (2015)
Keywords: africa, brown syndrome, amblyopia, child, eye movement, squint
MeSH terms: Amblyopia / etiology, Ocular Motility Disorders / diagnosis, Strabismus / etiology, Case Reports, Child, Female, Humans, Nigeria, Ocular Motility Disorders / physiopathology, Severity of Illness Index, Syndrome, Visual Acuity

Brown syndrome is a rare form of strabismus that is characterised by restriction of elevation of the eye in adduction. This is a case report of an eleven year old Nigerian girl who presented with a history of squint and poor vision. She had visual acuities of 6/24 and counting fingers in her right and left eyes respectively. There was a left hypotropia in the primary position of gaze with associated marked restriction of elevation in adduction and a positive forced duction test. Refraction revealed a refractive error of +4.50 diopters in each eye. The right visual acuity improved significantly to 6/9 with the refractive correction while the left visual acuity improved marginally to 6/60. This report demonstrates the occurrence of Brown syndrome with associated severe amblyopia in Africa. Health care providers are encouraged to promptly refer all patients, especially children, who have ocular motility disorders for early specialist intervention.
Hepatitis E during Tocilizumab Therapy in a Patient with Rheumatoid Arthritis: Case Report and Literature Review
Authors: Hidekazu Ikeuchi, Kana Koinuma, Masao Nakasatomi, Toru Sakairi, Yoriaki Kaneko, Akito Maeshima, Yuichi Yamazaki, Hiroaki Okamoto, Toshihide Mimura, Satoshi Mochida, Yoshihisa Nojima, Keiju Hiromura
Journal: Case Rep Rheumatol (2018)
MeSH terms: Case Reports

Hepatitis E is an acute self-limiting disease caused by hepatitis E virus (HEV). Recent reports show that HEV can induce chronic hepatitis or be reactivated in immunocompromised hosts. We report a 63-year-old woman with rheumatoid arthritis (RA) who developed hepatitis E during treatment with tocilizumab. Analysis of serially stocked serum samples confirmed that hepatitis was caused by primary infection with HEV and not by viral reactivation. Her liver function improved after discontinuing tocilizumab and remained within the normal range without reactivation of HEV for >5 years after restarting tocilizumab. We also reviewed the published cases of hepatitis E that developed during RA treatment.
Acute myocardial infarction after inactivated COVID-19 vaccination: a case report and literature review
Authors: Weimei Ou, Bin Wang, Guoming Zhang, Licheng Ding, Zhixian Liu, Kaimin Wu, Guangfeng Sun, Chengmin Huang, Zhaokai Li, Shuyuan Feng, Rui Gao
Journal: Front Cardiovasc Med (2023)
Keywords: covid-19 vaccination, acute myocardial infarction (ami), coronary heart disease (chd), coronary thrombosis, kounis syndrome (ks)
MeSH terms: Case Reports

A number of vaccines have been developed and deployed globally to restrain the spreading of the coronavirus disease 2019 (COVID-19). The adverse effect following vaccination is an important consideration. Acute myocardial infarction (AMI) is a kind of rare adverse event after COVID-19 vaccination. Herein, we present a case of an 83-year-old male who suffered cold sweat ten minutes after the first inactivated COVID-19 vaccination and AMI one day later. The emergency coronary angiography showed coronary thrombosis and underlying stenosis in his coronary artery. Type II Kounis syndrome might be a potential mechanism, which is manifested as coronary thrombosis secondary to allergic reactions in patients with underlying asymptomatic coronary heart disease. We also summarize the reported AMI cases post COVID-19 vaccination, as well as overview and discuss the proposed mechanisms of AMI after COVID-19 vaccination, thus providing insights for clinicians to be aware of the possibility of AMI following COVID-19 vaccination and potential underlying mechanisms.
Lack of Catch-Up Growth with Growth Hormone Treatment in a Child Born Small for Gestational Age Leading to a Diagnosis of Noonan Syndrome with a Pathogenic PTPN11 Variant
Authors: Daniel J Olivieri, Lauren J Massingham, Jennifer L Schwab, Jose Bernardo Quintos
Journal: Case Rep Endocrinol (2021)
MeSH terms: Case Reports

Background:
Growth hormone (GH) treatment increases the adult height of short children born small for gestational age (SGA). Catch-up growth is associated with a younger age, shorter height, and prepubertal status at the onset of GH treatment. We report a 12 11/12-year-old girl born SGA who received GH for 5 years without catch-up growth and was diagnosed with Noonan Syndrome (NS).
Results:
A 5-year-and-9-month-old 46, XX girl born SGA was started on GH treatment at a dose of 0.32 mg/kg/week. Her midparental target height is 158.6 cm. Endocrine work up showed an IGF-1 level 69 ng/ml (Normal (N): 55-238 ng/ml), IGFBP3 2.6 mg/L (N: 1.9-5.2 mg/L), TSH 3.2 mIU/L (N: 0.35-5.5 mIU/L), and a normal skeletal survey. Height was 96 cm (0.1%; Ht SDS -2.9), weight 14 kgs (1%; Wt SDS -2.3), and Tanner 1 breast and pubic hair were observed. Due to the poor catch-up growth on GH treatment, she was referred to Genetics to elucidate genetic or syndromic causes of short stature. She was noted to have posteriorly rotated ears and slight down slanting of the palpebral fissures. Genetic findings showed a heterozygous pathogenic variant in PTPN11 (c.922A > G (p.Asn308Asp)) diagnostic for NS. This finding is de novo given negative parental testing. She was noted to have a heterozygous missense variant of unknown significance (VUS) in FGFR3: c.746C > A (p.Ser249Tyr). FGFR3 is associated with multiple skeletal dysplasias including thanatophoric dysplasia, achondroplasia, and Crouzon syndrome and hypochondroplasia. Clinical correlation is poor for these syndromes.
Conclusion:
Diminished catch-up growth and response to GH treatment in a child born SGA led to the diagnosis of NS. The concomitant diagnosis of SGA and NS may have affected the responsiveness of this child to the growth promoting effect of GH treatment.