OpenMed/multicare-articles huggingface dataset:
Case report: Directional infusion of peripheral blood stem cells into the necrotic zone in femoral heads through the medial circumflex femoral artery: A tracing study
Authors: Qiang Mao, Weijie Shao, Shuaijie Lv, Peijian Tong, Bangjian He
Journal: Front Med (Lausanne) (2022)
Keywords: 18f-fdg, cell tracking, medial circumflex femoral artery, osteonecrosis of the femoral head, peripheral blood stem cells
MeSH terms: Case Reports

Objective:
This study aimed to explore whether peripheral blood stem cells (PBSCs) infused through the medial circumflex femoral artery to treat osteonecrosis of the femoral head (ONFH) could migrate into the necrotic area of femoral head.
Methods:
We collected PBSCs from a patient who had bilateral ONFH by apheresis technique using COBE spectra apheresis system (COBE BCT Inc, Lakewood, CO, USA) after subcutaneous injections of granulocyte-colony stimulating factor (G-CSF) at a dosage of 10 μg/kg for 4 days to mobilize PBSCs. After that, 100 MBq 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) was used to label PBSCs. 18F-FDG labeled PBSCs were infused into the left femoral head via the medial circumflex femoral artery to treat ONFH. Then the patient was underwent three-dimensional positron emission tomography (3D-PET) examination 60 min after cell infusion to monitor the biological distribution of 18F-FDG-labeled PBSCs, and to observe whether the transplanted PBSCs could migrate into the necrotic area of femoral head.
Results:
The total number of monouclear cells in the peripheral blood stem cell suspension was 1.95 × 108 which contained 2.20 × 106 CD34+ cells. The activity of 18F-FDG in the labeled cells was 1.8Bq/103 monouclear cells. 3D-PET imaging showed that 18F-FDG radioactivity was detected in the necrotic area of femoral head, acetabulum and femoral bone marrow cavity after transplantation of 18F-FDG-labeled PBSCs via the medial circumflex femoral artery. It is worth noting that although PBSCs labeled with 18F-FDG were widely distributed around the hip, such as femoral bone marrow cavity, femoral head and acetabulum, PBSCs were generally located in the necrotic area of femoral head.
Conclusions:
PBSCs could enter into the femoral head and migrate into the necrotic field of femoral head participating in the repair of osteonecrosis after infusion through the medial circumflex femoral artery.
Ocular Dirofilariasis after Clinically Manifested Subcutaneous Migration of the Parasite: A Case Report
Authors: František Ondriska, Vojtech Boldiš, Marta Stanislavová, Daniela Antolová, Martina Miterpáková, Anton Hanáček, Soňa Vešperová, Ivan Jančovič
Journal: Iran J Parasitol (2020)
Keywords: dirofilaria repens, dirofilariasis, ocular infection, slovakia, subcutaneous migration
MeSH terms: Case Reports

Dirofilaria repens is the causative agent of human subcutaneous or, less often, ocular dirofilariasis. The work presents a rare case of ocular dirofilariasis manifested by previous subcutaneous migration accompanied by severe headache symptoms. In February 2017, a 58-yr-old man from Trnava region, western Slovakia, noticed red and itchy stripes on his left leg. Inflamed but painless stripes disappeared and showed up again every 5-7 days, migrating gradually towards the head. Approximately one month after the first skin's alterations, strong pain in the left temple, with the swelling of the left face and the enlargement of mandibular lymph nodes appeared. Several days later, the patient felt excruciating pain of the right eyeball accompanied by strong nausea and subsequent vomiting. Ocular examination revealed the presence of a live worm in the subconjunctival space and morphological and molecular analyses of extracted helminth confirmed D. repens as etiological agent of the infection. According to clinical manifestation of the infection, it could be supposed that ocular form of the disease was the result of the migration of a parasite through the subcutaneous tissues. Moreover, a rare phenomenon of lymphadenitis of underlying lymph nodes and the swelling of left face accompanied the migration.
Left Ventricular Thrombus as a Complication of Clozapine-Induced Cardiomyopathy: A Case Report and Brief Literature Review
Authors: Shahbaz A Malik, Sarah Malik, Taylor F Dowsley, Balwinder Singh
Journal: Case Rep Cardiol (2015)

A 48-year-old male with history of schizoaffective disorder on clozapine presented with chest pain, dyspnea, and new left bundle branch block. He underwent coronary angiography, which revealed no atherosclerosis. The patient's workup was unrevealing for a cause for the cardiomyopathy and thus it was thought that clozapine was the offending agent. The patient was taken off clozapine and started on guideline directed heart failure therapy. During the course of hospitalization, he was also discovered to have a left ventricular (LV) thrombus for which he received anticoagulation. To our knowledge, this is the first case report of clozapine-induced cardiomyopathy complicated by a LV thrombus.
AIRE Gene Mutation Presenting at Age 2 Years With Autoimmune Retinopathy and Steroid-Responsive Acute Liver Failure: A Case Report and Literature Review
Authors: Hirotaka Sakaguchi, Tatsuki Mizuochi, Masatoshi Haruta, Ryuta Takase, Shigeo Yoshida, Yushiro Yamashita, Ryuta Nishikomori
Journal: Front Immunol (2021)
Keywords: aire, acute liver failure, autoimmune hepatitis, children, corticosteroid
MeSH terms: Adrenal Cortex Hormones / administration & dosage, Autoimmune Diseases / drug therapy, Liver Failure, Acute / drug therapy, Methylprednisolone / administration & dosage, Mutation, Polyendocrinopathies, Autoimmune / drug therapy, Retinal Diseases / drug therapy, Transcription Factors / genetics, Case Reports, Review, Administration, Intravenous, Autoantibodies / blood, Autoimmune Diseases / diagnosis, Autoimmune Diseases / genetics, Autoimmune Diseases / immunology, Azathioprine / administration & dosage, Child, Preschool, Drug Therapy, Combination, Female, Genetic Predisposition to Disease, Humans, Immunosuppressive Agents / administration & dosage, Liver Failure, Acute / diagnosis, Liver Failure, Acute / genetics, Liver Failure, Acute / immunology, Phenotype, Polyendocrinopathies, Autoimmune / diagnosis, Polyendocrinopathies, Autoimmune / genetics, Polyendocrinopathies, Autoimmune / immunology, Pulse Therapy, Drug, Recoverin / immunology, Retinal Diseases / diagnosis, Retinal Diseases / genetics, Retinal Diseases / immunology, Treatment Outcome, APECED protein, Adrenal Cortex Hormones, Autoantibodies, Immunosuppressive Agents, RCVRN protein, human, Transcription Factors, Recoverin, Azathioprine, Methylprednisolone

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare monogenic autosomal recessive disorder caused by mutation in the autoimmune regulator (AIRE) gene. Patients usually are diagnosed at ages between 5 and 15 years when they show 3 or more manifestations, most typically mucocutaneous candidiasis, Addison's disease, and hypoparathyroidism. APECED-associated hepatitis (APAH) develops in only 10% to 40% of patients, with severity varying from subclinical chronic active hepatitis to potentially fatal acute liver failure (ALF). Ocular abnormalities are fairly common, most often keratopathy but sometimes retinopathy. Here we report a 2-year-old Japanese girl with an AIRE gene mutation who developed APAH with ALF, preceded by autoimmune retinopathy associated with anti-recoverin antibody before major symptoms suggested a diagnosis of APECED. Intravenous pulse methylprednisolone therapy followed by a corticosteroid combined with azathioprine treatment resolved ALF and achieved control of APAH. To our knowledge, our patient is the youngest reported to have ALF resulting from an AIRE gene mutation. Pulse methylprednisolone induction therapy followed by treatment with corticosteroid plus azathioprine may well be effective in other children with APAH and AIRE gene mutations.
Necrotizing Pseudomonas aeruginosa Community-Acquired Pneumonia: A Case Report and Review of the Literature
Authors: Satish Maharaj, Carmen Isache, Karan Seegobin, Simone Chang, Grant Nelson
Journal: Case Rep Infect Dis (2017)
MeSH terms: Case Reports

Lung cavities are not typically associated with community-acquired pneumonia (CAP). CAP due to P. aeruginosa is rare and even less commonly causes necrotizing pneumonia. We report a case of P. aeruginosa CAP that progressed to necrotizing pneumonia and was eventually fatal. Procalcitonin (PCT) has been well investigated in guiding antibiotic therapy (especially CAP) in adults. In this case, PCT at presentation and sequentially was negative. We discuss this caveat and present hypotheses as to the sensitivity and specificity of PCT and C-reactive protein (CRP) in these patients. To better characterize P. aeruginosa CAP, we undertook a review of cases indexed in PubMed from 2001 to 2016 (n = 9). The data reveal that risk factors for P. aeruginosa CAP include smoking, alcohol use, obstructive lung disease, sinusitis, and hot tub use. The route of infection for P. aeruginosa CAP remains unknown. One of the most interesting findings on reviewing cases was that P. aeruginosa CAP involves the right upper lobe in the vast majority. We suggest that when physicians in the community see patients with distinctly upper lobe necrotizing or cavitary pneumonia, they should consider P. aeruginosa in their differential diagnosis. Further studies are needed to clarify route of infection, role of PCT and CRP, and optimal therapy including drug and duration.
Peritoneal metastases from malignant degeneration of ectopic gastric epithelium in Meckel's diverticulum: A case report
Authors: Ehab El Bahesh, Bruce M Abell, Paul H Sugarbaker, Antoine Finianos, Marilyn Baird-Howell, James D Ahlgren
Journal: Int J Surg Case Rep (2019)
Keywords: complete remission, meckel diverticulum, metastatic adenocarcinoma, o-max chemotherapy

Background:
Meckel's diverticulum is the most common congenital anomaly of the gastrointestinal tract, resulting from incomplete obliteration of the omphalomesenteric duct in early fetal development. The diverticulum frequently contains ectopic gastrointestinal epithelial tissue, most commonly gastric or pancreatic. Adenocarcinoma can arise from either of these epithelia but is extremely rare, with less than 50 cases reported in the world literature.
Methods:
In a patient with peritoneal metastases from ectopic gastric mucosae in a Meckel's diverticulum a multidisciplinary treatment plan was initiated.
Results:
Diagnosis was evident from study of the resected specimen of small bowel in a patient with acute abdominal pain. A multiagent chemotherapy regimen using oxaliplatin, mitomycin C, doxorubicin, and capecitabine (O-Max) resulted in a clinical and radiologic response. A second surgery with extensive sampling of tissues from the abdomen and pelvis confirmed a complete response to systemic chemotherapy. At four years from onset of disease the patient has no evidence of recurrence.
Conclusions:
Peritoneal metastases from malignant degeneration of ectopic gastric epithelium in a Meckel's diverticulum was reported. Multidisciplinary treatments were beneficial.
Odontoameloblastoma
Authors: Alka Dive, Shubhangi Khandekar, Ashish Bodhade, Akshay Dhobley
Journal: J Oral Maxillofac Pathol (2011)
Keywords: odontoameloblastoma, ameloblasic dentinoma, mixed odontogenic tumor
MeSH terms: Case Reports

Odontoameloblastoma (OA) is an extremely rare mixed odontogenic tumor with both epithelial and mesenchymal components. OA develops from proliferating odontogenic epithelium and mesenchymal tissue. Till date, around 20 cases have fulfilled the histologic criteria of the current World Health Organization (WHO) histologic classification of odontogenic tumors. It affects predominantly young patients with a median age of 20.12 years, and has a predilection for males and occurs in posterior segments of either jaw with slight inclination for mandible. Review of literature shows only three reported cases in the anterior mandible. Here, we report a case of OA in the anterior mandible.
An arcane presentation of pustular psoriasis in pregnancy: case report
Authors: Arun Raja, Pragadeesh Palaniappan, Devika Sankar, Krishna Prasanth Baalann
Journal: Pan Afr Med J (2022)
Keywords: pustular psoriasis of pregnancy, case report, generalized pustular psoriasis, impetigo herpetiformis
MeSH terms: Dermatitis Herpetiformis / diagnosis, Impetigo / complications, Impetigo / diagnosis, Impetigo / pathology, Psoriasis / diagnosis, Psoriasis / drug therapy, Skin Diseases, Vesiculobullous / pathology, Case Reports, Adult, Cesarean Section, Female, Humans, Pregnancy, Skin / pathology

Pustular psoriasis of pregnancy (PPP) also known as impetigo herpetiformis is a well-described dermatosis of pregnancy characterized by the fatal progression of disease for both the mother and the foetus if left untreated. A 28-year-old G2P1L1 pregnant mother at 28 weeks of gestation, came to outpatient department (OPD) with complaints of scaly skin lesions all over her body along with fever, nausea and generalised weakness. On examination, there were erythematous scaly patches in the trunk, back, hands and legs accompanied by formation of pustules in the periphery of the lesions. Histopathological examination was consistent with pustular psoriasis. Patient was managed with prednisolone (40 mg/day which was later tapered). Serial antenatal visits and ultrasounds were done to monitor the health of the mother and foetal growth. Under the support of obstetrician, patient delivered a healthy female baby through caesarean section under general anaesthesia. Her lesions persisted in the postpartum period, which later started reducing gradually.
Environmental factors influencing the risk of ANCA-associated vasculitis
Authors: Wen-Man Zhao, Zhi-Juan Wang, Rui Shi, Yu-Yu Zhu, Sen Zhang, Rui-Feng Wang, De-Guang Wang
Journal: Front Immunol (2022)
Keywords: aav (anca-associated vasculitis), anca, air pollution, environmental risks, etiology, vasculitis
MeSH terms: Air Pollutants, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / drug therapy, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / epidemiology, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / etiology, Churg-Strauss Syndrome / complications, Granulomatosis with Polyangiitis, Meta-Analysis, Review, Research Support, Non-U.S. Gov't, Antibodies, Antineutrophil Cytoplasmic, Carbon Monoxide / therapeutic use, Endothelial Cells / pathology, Humans, Inflammation / complications, Peptide Hydrolases, Silicon Dioxide, Air Pollutants, Antibodies, Antineutrophil Cytoplasmic, Silicon Dioxide, Carbon Monoxide, Peptide Hydrolases

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of diseases characterized by inflammation and destruction of small and medium-sized blood vessels. Clinical disease phenotypes include microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA), and eosinophilic granulomatosis with polyangiitis (EGPA). The incidence of AAV has been on the rise in recent years with advances in ANCA testing. The etiology and pathogenesis of AAV are multifactorial and influenced by both genetic and environmental factors, as well as innate and adaptive immune system responses. Multiple case reports have shown that sustained exposure to silica in an occupational environment resulted in a significantly increased risk of ANCA positivity. A meta-analysis involving six case-control studies showed that silica exposure was positively associated with AAV incidence. Additionally, exposure to air pollutants, such as carbon monoxide (CO), is a risk factor for AAV. AAV has seasonal trends. Studies have shown that various environmental factors stimulate the body to activate neutrophils and expose their own antigens, resulting in the release of proteases and neutrophil extracellular traps, which damage vascular endothelial cells. Additionally, the activation of complement replacement pathways may exacerbate vascular inflammation. However, the role of environmental factors in the etiology of AAV remains unclear and has received little attention. In this review, we summarized the recent literature on the study of environmental factors, such as seasons, air pollution, latitude, silica, and microbial infection, in AAV with the aim of exploring the relationship between environmental factors and AAV and possible mechanisms of action to provide a scientific basis for the prevention and treatment of AAV.
Extreme Procalcitonin Elevation without Proven Bacterial Infection Related to Amphetamine Abuse
Authors: András Lovas, Zsuzsanna Agoston, Klára Késmárky, Péter Hankovszky, Zsolt Molnár
Journal: Case Rep Crit Care (2014)

Systemic inflammatory response with rhabdomyolysis and consequent multiorgan failure is a known sequela of psychotropic drug abuse. However, in cases with uncertain past medical history the initial diagnosis can be challenging. Here we report the case of a 21-year-old male who was admitted to the intensive care unit with severe neurological impairment caused by amphetamine intoxication. First laboratory investigations revealed extremely high serum procalcitonin (PCT) levels reaching a maximum concentration of 1640 ng/mL on the second day of observation. Although PCT has high sensitivity and specificity in differentiating bacterial sepsis from nonbacterial inflammation, our case report shows for the first time that it can be extremely elevated following serious amphetamine intoxication without bacterial infection.
Huge desmoid tumor of the anterior abdominal wall mimicking an intraabdominal mass in a postpartum woman: a case report
Authors: Khaled Trigui, Mahdi Bouassida, Houda Kilani, Mohamed Mongi Mighri, Selim Sassi, Fathi Chebbi, Hassen Touinsi, Sadok Sassi
Journal: Pan Afr Med J (2013)
Keywords: desmoid tumors, post partum, surgery
MeSH terms: Abdominal Neoplasms / pathology, Abdominal Wall, Fibromatosis, Aggressive / pathology, Soft Tissue Neoplasms / pathology, Case Reports, Adult, Diagnosis, Differential, Female, Humans, Postpartum Period

Desmoid tumors are benign neoplasms that most often arise from muscle aponeurosis and have been associated with both trauma and pregnancy. The etiology of desmoids has not been determined. We report the case of anterior abdominal wall desmoid tumor in a female patient with previous history of cesarean section. Preoperative ultrasound and computed tomography demonstrated a large mass mimicking a large hematoma or an intraabdominal mass. The tumor was removed by wide excision with safe margins. The abdominal wall defect was reconstructed with polypropylene mesh. Subsequent histology revealed a desmoid tumor. Desmoid tumors in females are often associated with pregnancy or occur post-partum. The reasons behind this association are unclear. The most common sites are in the abdominal muscles.
Pediatric fibroma in maxillary sinus following nasal trauma: A case report
Authors: M Akdağ
Journal: Int J Surg Case Rep (2019)
Keywords: fibroma, maxillofacial trauma, surgery of maxiller fibroma

Introduction:
Fibroma is a benign tumor of the connective tissue and is classified among the fibrous and fibrous histiocytic lesions. In the pediatric age group, both the differential diagnosis and surgery of maxillary swellings are difficult.
Case reports:
A 26-month old girl applied with swelling and malformation in the nose. She complained of swelling in the right cheek, nasal obstruction and dyspnea during the night time. Her family stated that she had a head trauma 45 days before the application. We observed a rigid mass in the lateral side of the right nasal region consistent with severe edema. The pediatric endoscopic examination displayed a passage obstruction and an expansion of the lateral wall towards the septum. We performed right Caldwell-Luc approach with the endoscopic transnasal approach. The pathological examination with the light microscope displayed dense and thick collagen fibers and fusiform fibroblasts mixed up with these collagen fibers.
Discussion:
Fibroma and fibroma like lesions are rare and difficult to diagnose. In the Pubmed database, we did not encounter any large-scale study focused on this type of tumors except for some case reports of fibromyxoma. In respect of the findings in the literature, along with the pathological criteria, the clinicopathological correlation and radiological imaging may facilitate the diagnosis. Furthermore, a good cooperation with the patient and his/her family and a reliable history like trauma are also critical.
Conclusion:
The possibility of trauma should be definitively questioned during the history of pediatric patients, who applied with a maxillofacial swelling with the presence of persistent edema and differential diagnosis for the soft tissue tumors like fibroma should be considered.
A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Epstein-Barr Virus-Negative Reed-Sternberg-Like B-Cells, Chylous Ascites, and Chylothorax
Authors: Mathijs Willemsen, Arne W J H Dielis, Iryna V Samarska, Ad Koster, Arienne M van Marion
Journal: Case Rep Hematol (2017)
MeSH terms: Case Reports

Angioimmunoblastic T-cell lymphoma is a rare non-Hodgkin lymphoma with dismal prognosis. The median age of presentation ranges from 62 to 69 years with generalized lymphadenopathy, B symptoms, and hepatosplenomegaly as the most prevalent symptoms. The combination of B-cell and T-cell proliferations is common in AITL and the B-cell component may resemble Reed-Sternberg-like B-cells. Epstein-Barr virus is estimated to be present in 80-95% of AITL biopsies. Only a handful of EBV-negative AITL cases with EBV-negative RS-like B-cells have been reported over the last decade. We present a rare case of EBV-negative AITL with chylous ascites and chylothorax. Microscopic and immunohistochemical analysis revealed the presence of EBV-negative Reed-Sternberg-like B-cells in the tumor.
A case study of the construction of inter-embedded multi-ethnic community of urban migrants in Nanyang
Authors: Qiang Sun, Dongxu Liu
Journal: Int J Anthropol Ethnol (2022)
Keywords: china, domestic population mobility, inter-embedded multi-ethnic community, jade trade, living around the market, uygurs

As the domestic interprovincial migrants, Uygur traders have been engaged in the Hetian jade trade from Xinjiang Uygur Autonomous Region to the city of Nanyang in Henan Province. Having lived in the private rented houses around the market in the early days, they moved into the government-built public rental housing in 2017, an independently managed community. They have maintained their past residential pattern of living around the market, and gradually develop the community into an inter-embedded multi-ethnic community together with other ethnic groups. Through the history of the formation of the Uygur community in Nanyang Stone Town, this paper presents the process of interaction between the ethnic minority migrants and the local community, examines the responses and influence of the market, society, government, and individuals in this process, aiming to understand how the minority community was formed, to deepen understanding of the "inter-embedded multi-ethnic community", and, in turn, to promote research and reflection on the development of the ethnic community during urbanization in China. This study suggests that such communities surrounding the market are socially extended based on inter-embedded livelihood. The open national market is the core of the social structure of inter-embedded ethnic groups, and market exchange is one of the main relations generated in the current interactions between the ethnic groups. The government's efforts to build inter-embedded communities are conducive to transforming the relationships among ethnic groups from limited interaction to comprehensive and balanced development. Moreover, the improvement of common living environments and increase in exchanges are conducive to upgrading interactions between individuals to extensive and in-depth exchanges among different ethnic groups.