OpenMed/multicare-articles huggingface dataset:
A Case of Recurrent Esophageal Cancer Treated with Concurrent Chemoradiation Therapy in Pregnancy
Authors: Kaori Yamada, Yoshitsugu Chigusa, Motoo Nomura, Katsuyuki Sakanaka, Mitsuhiro Nakamura, Shinsuke Yano, Shigeru Tsunoda, Eiji Kondoh, Masaki Mandai
Journal: Case Rep Obstet Gynecol (2018)
MeSH terms: Case Reports

Esophageal cancer rarely coincides with pregnancy, and only five cases have been reported thus far. The management of esophageal cancer during pregnancy is extremely challenging due to its aggressive nature. We herein report a case of recurrent esophageal cancer in pregnancy. A 41-year-old multigravida with a history of esophageal squamous cell cancer treated with esophagectomy and perioperative chemotherapy was diagnosed with local recurrent carcinoma of the residual esophagus at 16 weeks of gestation. The patient strongly desired to continue the pregnancy, and concurrent chemoradiation therapy (CRT) consisting of 50.4 Gy of radiation, cisplatin, and 5-fluorouracil was carried out from 19 weeks of gestation. CRT was dramatically effective, and the recurrent lesion disappeared. At 38 weeks of gestation, she underwent cesarean section and delivered a healthy female baby. Both maternal and fetal courses were satisfactory, and the patient has been free of disease for 12 months. This is the first case of recurrent esophageal cancer in pregnancy in which CRT was completed without reducing treatment intensity and led to a complete response. Nevertheless, little is known regarding the safety and possible adverse effects of CRT on the fetus. Therefore, deliberate selection of patients and long-term follow-up of the child are necessary.
Penetrating head trauma: 03 rare cases and literature review
Authors: Youssef Fahde, Mehdi Laghmari, Mohamed Skoumi
Journal: Pan Afr Med J (2017)
Keywords: ct scan, penetrating head trauma, craniectomy, infection
MeSH terms: Foreign Bodies / complications, Head Injuries, Penetrating / therapy, Case Reports, Review, Adolescent, Child, Preschool, Female, Humans, Intracranial Hemorrhage, Traumatic / therapy, Intracranial Pressure, Male, Prognosis

Penetrating head trauma (PHT) include all open head injuries with foreign object in the brain. Although less common than closed head trauma, penetrating head trauma carry a worse prognosis. We received three unusual cases of penetrating head injuries whose prognosis was different according to clinical presentation and initial management of the patient. Treatment of penetrating head trauma aims at controlling bleeding, controlling intracranial pressure and preventing infections. Despite the efforts made by national authorities as well as the adequate management in hospitals, penetrating head injuries are still frequent with significant mortality and morbidity.
Case Report of Bilateral 3-4 Metatarsal Syndactyly in a Pet Rabbit
Authors: M Gallego, L Avedillo
Journal: Case Rep Vet Med (2016)
MeSH terms: Case Reports

We report the first case of spontaneous syndactyly reported in a pet rabbit. Syndactyly only caused an atypical gait in the rabbit. The radiological study revealed bilateral 3rd and 4th metatarsal bones fused in its entire length preserving normal joint surfaces resembling syndactyly type Ia. The cause of this congenital malformation was unknown.
A giant aneurysmal bone cyst of the rib: Case report
Authors: Juntang Guo, Chaoyang Liang
Journal: Oncol Lett (2014)
Keywords: aneurysmal bone cyst, rib, tumor

An aneurysmal bone cyst (ABC) is a benign tumor of the skeletal system, which most frequently occurs in long bones. An ABC arising from the rib is extremely rare and it is difficult to distinguish from other types of rib tumors. The present study describes an unusual case of a large ABC in the rib of a 17-year-old male. The entity is discussed with particular emphasis on the clinicopathological features, differential diagnosis and treatment. Due to difficulties in the pre-operative diagnosis, a possible diagnosis of ABC should be made aware when confronting an expansile rib mass. An en bloc resection of the mass and the affected portion of the rib is mandatory to obtain a satisfactory outcome.
Complete Regression of Giant Aneurysms in an Infant with Delayed Diagnosis and Refractory Kawasaki Disease via Combination Anticytokine Therapy: Case Report and Review of Similar Cases
Authors: Maegan Williams, Lakshmi Nagaraju, Mark Gorelik
Journal: Case Rep Rheumatol (2020)
MeSH terms: Case Reports

Background:
Kawasaki disease (KD) is an inflammatory vasculitis and is the most common cause of acquired childhood heart disease in developed countries. Current treatment with intravenous immunoglobulin (IVIG) is often ineffective in patients with delayed or refractory disease. We present a case of combination anticytokine therapy in an infant with delayed and refractory KD. Case Presentation. A 3-month-old infant presented with refractory KD with giant aneurysms after a delayed diagnosis of one month. Use of combination anticytokine therapy led to resolution of giant aneurysms over approximately 6 months.
Conclusions:
Our case is unique in effective use of anticytokine therapy in very delayed disease with giant aneurysms. Additionally, we review other cases for a broader perspective. Prospective study of anticytokine therapy for patients with giant aneurysms may be warranted.
Right Atrial Fibroelastoma Presenting as Typical Atrial Flutter: Rare Disease in Unusual Location
Authors: Ahmad Abuarqoub, Ghada Elshimy, Muhammed Shittu, Aiman Hamdan, Fayez Shamoon
Journal: Case Rep Cardiol (2017)
MeSH terms: Case Reports

Typical atrial flutter as initial presentation of papillary fibroelastoma involving the cavotricuspid isthmus is not described before in literature. To our knowledge only 14 cases have been reported in literature involving the right atrium. Very unusual location is at the junction between inferior vena cava (IVC) and right atria as only 1 case has been reported.
Fish bone perforation mimicking colon cancer: A case report
Authors: Thokozani Sibanda, Pria Pakkiri, Anne Ndlovu
Journal: SA J Radiol (2020)
Keywords: abscess, bowel perforation, colonic malignancy, computed tomography, fish bone, hemicolectomy

Most patients who ingest fish bones do not develop any complications. The small proportion of patients who do complicate, present with non-specific symptoms. A 64-year-old female patient presented with a 2-month history of abdominal pain. Following clinical evaluation and computed tomography scan of the abdomen, a provisional diagnosis of colon cancer was made. Histology of the resected bowel at hemicolectomy demonstrated a perforation by fish bone with an associated abscess. The case illustrates how fish bone perforation may mislead unsuspecting clinicians and may be misdiagnosed as colonic cancer.
Diagnostic aspects and retinal imaging in ocular toxocariasis: a case report from Italy
Authors: Onelia Verallo, Serena Fragiotta, Francesca Verboschi, Enzo Maria Vingolo
Journal: Case Rep Med (2012)
MeSH terms: Case Reports

Toxocara canis is a nematode parasite, commonly found in dogs. This roundworm parasite can invade the eye, causing visual impairment. Toxocara should be considered as a possible causative agent of posterior and diffuse uveitis, and it could be considered in the differential diagnosis of retinoblastoma. Ocular manifestations vary from severe endophthalmitis to silent incidental findings on a routine examination. We report a case of ocular toxocariasis in a 24-year-old Asiatic female that presented to us complaining of visual impairment. Fundoscopic examination revealed a posterior pole granuloma and exudative retinal detachment along with exudates. Presentation, clinical findings, morphological changes, and treatment are discussed. The enzyme-linked immunosorbent assay serology for Toxocara canis was performed, demonstrating the positivity for IgG and IgE. Treatment with the antihelminthic albendazole was initiated. Fluorescein angiography (FA; HRA 2, Heidelberg engineering) and optical coherence tomography (OCT; Spectralis, Heidelberg tomography) were performed, and results have been reported.
Enactive Approach and Dual-Tasks for the Treatment of Severe Behavioral and Cognitive Impairment in a Person with Acquired Brain Injury: A Case Study
Authors: David Martínez-Pernía, David Huepe, Daniela Huepe-Artigas, Rut Correia, Sergio García, María Beitia
Journal: Front Psychol (2016)
Keywords: behavioral disorder, cognitive impairment, dual-tasks, enaction, neurorehabilitation, seated affordance

One of the most important sequela in persons who suffer from acquired brain injury is a behavioral disorder. To date, the primary approaches for the rehabilitation of this sequela are Applied Behavior Analysis, Cognitive-Behavior Therapy, and Comprehensive-Holistic Rehabilitation Programs. Despite this theoretical plurality, none of these approaches focuses on rehabilitating behavioral disorders considering the relation between affordance and environmental adaptation. To introduce this therapeutic view to neurorehabilitation, we apply the theoretical tenets of the enactive paradigm to the rehabilitation of a woman with severe behavioral and cognitive impairment. Over seventeen sessions, her behavioral and cognitive performance was assessed in relation to two seated affordances (seated on a chair and seated on a ball 65 cm in diameter) and the environmental adaptation while she was working on various cognitive tasks. These two seated affordances allowed to incorporate the theoretical assumptions of the enactive approach and to know how the behavior and the cognition were modified based on these two postural settings and the environmental adaptation. The findings indicate that the subject exhibited better behavioral (physical and verbal) and cognitive (matching success and complex task) performances when the woman worked on the therapeutic ball than when the woman was on the chair. The enactive paradigm applied in neurorehabilitation introduces a level of treatment that precedes behavior and cognition. This theoretical consideration allowed the discovery of a better relation between a seated affordance and the environmental adaptation for the improvement behavioral and cognitive performance in our case study.
Diffuse Pancreatic Carcinoma with Hepatic Metastases
Authors: Hoang Quan Nguyen, Ngoc Trinh Thi Pham, Van Trung Hoang, Hoang Anh Thi Van, Chinh Huynh, Duc Thanh Hoang
Journal: Case Rep Oncol Med (2020)
MeSH terms: Case Reports

Pancreatic cancer is one of the seven leading causes of cancer death worldwide. Diffuse pancreatic carcinoma is very rare and underreported in the literature. Many advances have been made in the diagnosis and management of pancreatic cancer. However, most pancreatic cancer cases are detected at the terminal or metastatic stages. Therefore, timely diagnosis and therapeutic management are desirable goals for this disease. Although the proliferation of pancreatic cancer has been reduced by intervention, more work is needed to treat and prevent the disease. The purpose of this article is to present a case of a 54-year-old male with pancreatic cancer and to review the epidemiology, diagnosis, management, and prevention of pancreatic tumors in general as well as pancreatic carcinoma in particular.
Bicornuate uterus and pregnancy: ambiguity diagnosis (a case report)
Authors: Hamidou Soumana Diaouga, Houegbelo Lazare Laurent, Maimouna Chaibou Yacouba, Fougou Laouane Ari Mamane, Madeleine Garba Rahamatou, Nafiou Idi, Madi Nayama
Journal: Pan Afr Med J (2022)
Keywords: bicornuate uterus, case report, pregnancy, uterine malformation
MeSH terms: Bicornuate Uterus, Urogenital Abnormalities / diagnostic imaging, Case Reports, Cesarean Section, Female, Humans, Pregnancy, Uterus / abnormalities, Uterus / diagnostic imaging, Uterine Anomalies

The frequency of uterine malformations is estimated in the general population to be between 1 and 4%. The bicornuate uterus accounts for about half of uterine abnormalities. The conception of a pregnancy and its evolution to term on this uterine abnormality is rare. During pregnancy, this malformation is asymptomatic and may go unnoticed in the absence of prenatal care. Ultrasound is essential for the diagnosis, which is often difficult in an environment of socio-economic precariousness and low technical facilities. We present the diagnostic difficulties, the therapeutic aspects and the obstetric prognosis of an unusual case of a unicervical bicornuate uterus revealed during a laparotomy which is both exploratory and diagnostic. Treatment consisted of close monitoring until 38 weeks when the patient underwent a scheduled cesarean section.
Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Psoriasis: A Case Report and Review of the Literature
Authors: Carolina Afonso, Adriana Roque, Cátia Almeida, Maria Beatriz Pimentão, Maria José Julião, Rodolfo Silva, Catarina Geraldes, Marília Gomes
Journal: Case Rep Hematol (2022)
MeSH terms: Case Reports

Iatrogenic immunodeficiency-associated lymphoproliferative disorders (LPDs) are heterogeneous clinicopathological entities developing in patients receiving immunosuppression. Outside the posttransplant setting, methotrexate (MTX), a drug commonly used for the treatment of autoimmune diseases, is an immunosuppressive agent frequently reported to be associated with LPD. MTX-associated LPD (MTX-LPD) includes a spectrum of lymphocytic proliferations, ranging from polyclonal hyperplasia to malignant lymphoma. MTX-LPD diagnosis can be challenging, as signs and symptoms are often nonspecific and may overlap with those of several other conditions, including exacerbation of the underlying autoimmune disease. Spontaneous regression of LPD after MTX discontinuation is characteristic of MTX-LPD, therefore avoiding chemotherapeutic intervention in a significant proportion of patients. Other cases, however, should receive chemotherapy.
Case report: Novel use of the conventional method- chemical nail avulsion may be effective for treatment of green nail syndrome
Authors: Qian Yu, Yuanyuan Wang, Hong Yang, Wei Li, Lianjuan Yang
Journal: Front Med (Lausanne) (2022)
Keywords: pseudomonas aeruginosa, chemical nail avulsion, green nail syndrome, predisposing factors, urea powder
MeSH terms: Case Reports

Green nail syndrome (GNS) is a triad of green discoloration of the nail plate, proximal paronychia, and distal onycholysis. Pseudomonas aeruginosa is known to be the most common causative agent; however, there is no unified standard for the diagnosis and treatment of GNS. Thus, treatment is challenging and often refractory. Here, we report three representative cases with different predisposing factors, including trauma-related, occupation-related, and onychosis-related GNS. Patients with GNS accompanied by onycholysis were instructed to undergo chemical nail avulsion combined with topical antibiotics, and favorable curative effects were observed in all cases. Chemical nail avulsion with urea powder as a conventional method may be an effective treatment for GNS and warrants clinical generalization.
A young man with myelosuppression caused by clindamycin: a case report
Authors: Manuel Polanco Morales, Anna Paola Thome Carvallo, Karla Adriana Bautista Espinosa, Edgar Enrique Meza Murillo
Journal: J Med Case Rep (2014)

Introduction:
Clindamycin is used to treat various bacterial infections, but its administration can cause anaphylaxis, liver reactions, pseudomembranous colitis, and peripheral blood cytopenias (anemia, neutropenia, and thrombocytopenia), alone or in combination. We report the case of a patient with a recurrent infection of the tonsils who received clindamycin. Pancytopenia, a previously unreported hematological disorder related to clindamycin use, was observed in conjunction with the infection and clindamycin treatment.
Case presentation:
One month prior to hospitalization, a 22-year-old man of Hispanic origin had a tonsillar infection and cough and began to have anal pain. These conditions became exacerbated three weeks later, coinciding with a new tonsillar infection, frequent nonproductive cough, and febrile syndrome. He received clindamycin for four days prior to his admission, without improvement. While hospitalized, he was found to have fever, tonsillar abscess, hemorrhoid thrombosis, and anal fissure; the latter was immediately resected under general anesthesia. Before surgery, our patient's blood count showed intense leukoneutropenia and mild thrombocytopenia that increased 12 hours later, along with the establishment of anemia. A bone marrow study showed decreased cell content, micromegakaryocytes, and an interruption of the differentiation of granulocytes and erythroblasts. Post-surgery, our patient received metronidazole, meropenem, and amikacin along with acetaminophen, ketoprofen, omeprazole, and pegfilgrastim, with resulting clinical and hematological improvement.
Conclusion:
Our experience with this patient establishes that well-documented clinical cases should be the basis for identifying and publicizing unknown or uncommon undesirable effects of drugs. We report that, in some individuals, clindamycin can cause pancytopenia, a complication that in our patient's case was caused by direct injury of his hematopoietic tissue.
Rickettsialpox in North Carolina: a case report
Authors: Allan Krusell, James A Comer, Daniel J Sexton
Journal: Emerg Infect Dis (2002)
MeSH terms: Rickettsiaceae / isolation & purification, Rickettsiaceae Infections / diagnosis, Rickettsiaceae Infections / microbiology, Case Reports, Anti-Bacterial Agents / therapeutic use, Cefazolin / therapeutic use, Cephalosporins / therapeutic use, Doxycycline / therapeutic use, Humans, Male, Middle Aged, North Carolina / epidemiology, Rickettsiaceae Infections / drug therapy, Rickettsiaceae Infections / epidemiology, Serologic Tests, Anti-Bacterial Agents, Cephalosporins, Cefazolin, Doxycycline

We report a case of rickettsialpox from North Carolina confirmed by serologic testing. To our knowledge, this case is the first to be reported from this region of the United States. Including rickettsialpox in the evaluation of patients with eschars or vesicular rashes is likely to extend the recognized geographic distribution of Rickettsia akari, the etiologic agent of this disease.
Impacts of Regional Speed Control Strategy Based on Macroscopic Fundamental Diagram on Energy Consumption and Traffic Emissions: A Case Study of Beijing
Authors: Wensi Wang, Zirui Wang, Guangjun Wang, Bin Yu, Yuhe Xu, Kun Yu
Journal: Front Public Health (2022)
Keywords: macroscopic fundamental diagram, pm25 exposures, energy consumption, respiratory health, urban built roads
MeSH terms: Air Pollutants / analysis, Air Pollution / analysis, Research Support, Non-U.S. Gov't, Beijing, Environmental Monitoring / methods, Particulate Matter / analysis, Vehicle Emissions / analysis, Air Pollutants, Particulate Matter, Vehicle Emissions

Numerous studies shown that particulate matter in the ambient environment has a significant impact on the health of the respiratory system. To understand the interrelationships between urban built environment, transportation operations and health, this study proposes an innovative approach that uses real-world GPS datasets to calculate energy consumption and emissions from transportation. The experiment used the traffic operation state in the Fourth Ring Road of Beijing as the research object and tested the impact of using the Regional speed optimization (RSO) strategy based on Macroscopic Fundamental Diagram (MFD) on energy consumption and emissions during peak hours. The impact of traffic emission on the health of roadside pedestrians is also considered. Changes in PM2.5 concentrations around four different built-up areas were calculated and compared. The computational experiments indicate that the PM2.5 pollutants exhausted by the traffic on the Ring Road during peak hours can reach up to 250 μg/m3, while the traffic emission on general roads near residential areas is only 50 μg/m3. Adopting Regional speed optimization can reduce the energy consumption of the road network by up to 18.8%. For roadside runners, the PM2.5 inhalation caused by night running in commercial and recreational areas is about 1.3-2.6 times that of night running in residential areas. Compared with morning or night running, the risk of respiratory disease caused by PM2.5 inhalation was about 10.3% higher than commuter running behavior. The research results provide a useful reference for energy conservation and emission reduction control strategies for different road types in cities and help existing cities to establish a traveler health evaluation system caused by traffic operation.
Solid pseudopapillary neoplasm of the pancreas in an old man: age does not matter
Authors: Mahdi Bouassida, Mohamed Monji Mighri, Dhouha Bacha, Mohamed Fadhel Chtourou, Hassen Touinsi, Mohamed Msaddak Azzouz, Sadok Sassi
Journal: Pan Afr Med J (2012)
Keywords: solid pseudopapillary tumor, old, pancreas, prognosis, surgery
MeSH terms: Carcinoma, Papillary / diagnosis, Pancreas / pathology, Pancreatic Neoplasms / pathology, Case Reports, Aged, Carcinoma, Papillary / pathology, Carcinoma, Papillary / surgery, Diagnosis, Differential, Humans, Male, Pancreas / surgery, Pancreatic Neoplasms / diagnosis, Pancreatic Neoplasms / surgery

Solid pseudopapillary tumor (SPN) of the pancreas is a rare tumor, but has favorable prognosis. It is typically observed in young women. Only few cases have been reported in young men. We report the observation of a 73-year-old man presented with a palpable mass in the left upper abdomen. CT scan showed 10 cm mass at the tail of the pancreas. This mass had mixed cystic and solid components. The patient underwent a distal pancreatectomy and splenectomy. SPN of the pancreas was diagnosed based on histopathological features. The patient recovered uneventfully and didn't receive adjuvant therapy. A CT scan performed 16 months postoperatively showed no evidence of disease recurrence. Although SPN of the pancreas is typically observed in young women, the diagnosis should not be discounted in old male patients. Male patients and those with old age, atypical histopathology and incomplete resection may have a higher risk of recurrence and death, deserving particular attention.
Identification of MPL R102P Mutation in Hereditary Thrombocytosis
Authors: Christine Bellanné-Chantelot, Matthieu Mosca, Caroline Marty, Rémi Favier, William Vainchenker, Isabelle Plo
Journal: Front Endocrinol (Lausanne) (2017)
Keywords: camt, jak2, mpl r102p, thrombocytopenia, thrombocytosis, thrombopoietin
MeSH terms: Case Reports

The molecular basis of hereditary thrombocytosis is germline mutations affecting the thrombopoietin (TPO)/TPO receptor (MPL)/JAK2 signaling axis. Here, we report one family presenting two cases with a mild thrombocytosis. By sequencing JAK2 and MPL coding exons, we identified a germline MPL R102P heterozygous mutation in the proband and his daughter. Concomitantly, we detected high TPO levels in the serum of these two patients. The mutation was not found in three other unaffected cases from the family except in another proband's daughter who did not present thrombocytosis but had a high TPO level. The MPL R102P mutation was first described in congenital amegakaryocytic thrombocytopenia in a homozygous state with a loss-of-function activity. It was previously shown that MPL R102P was blocked in the endoplasmic reticulum without being able to translocate to the plasma membrane. Thus, this case report identifies for the first time that MPL R102P mutation can differently impact megakaryopoiesis: thrombocytosis or thrombocytopenia depending on the presence of the heterozygous or homozygous state, respectively. The paradoxical effect associated with heterozygous MPL R102P may be due to subnormal cell-surface expression of wild-type MPL in platelets inducing a defective TPO clearance. As a consequence, increased TPO levels may activate megakaryocyte progenitors that express a lower, but still sufficient level of MPL for the induction of proliferation.