OpenMed/multicare-articles huggingface dataset:
Extraskeletal myxoid chondrosarcoma: a case report
Authors: Anass Haloui, Nassira Karich, Asmae Aissaoui, Nada Akouh, Chaimae Bekhakh, Omar Mokhtari, Najib Abdeljaouad, Amal Bennani
Journal: Pan Afr Med J (2023)
Keywords: extraskeletal myxoid chondrosarcoma, case report, sarcoma, soft tissue
MeSH terms: Chondrosarcoma / diagnosis, Neoplasms, Connective and Soft Tissue, Sarcoma / diagnosis, Soft Tissue Neoplasms / pathology, Case Reports, Adult, Aged, Female, Humans, Chondrosarcoma, Extraskeletal Myxoid

Extraskeletal myxoid chondrosarcoma is a rare mesenchymal neoplasm of uncertain differentiation, characterized morphologically by abundant myxoid stroma, a multinodular growth pattern, and uniform cells arranged in strands, clusters, and reticular networks. It usually occurs in adults in the fifth decade, most often in the deep soft tissues of the proximal extremities. The molecular hallmark of this tumor, present in over 90% of cases, is the fusion of NR4A3 with EWSR1 at 22q12.2 or TAF15 at 17q12. Many other tumors with uniform tumor cells embedded in a myxoid matrix can mimic Extraskeletal myxoid chondrosarcoma, and the distinction can be difficult, often requiring immunohistochemistry and/or molecular testing. We herein report the case of an Extraskeletal myxoid chondrosarcoma that occurred in a 74-year-old woman who consulted for a slowly enlarging thigh mass, while highlighting the key morphologic, immunohistochemical, and molecular features of this rare type of soft tissue sarcoma, as well as a summary table gathering diagnostic features of relevance to the differential diagnosis.
Next-Generation Sequencing and Proteomics of Cerebrospinal Fluid From COVID-19 Patients With Neurological Manifestations
Authors: Haijun Wang, Zili Zhang, Junfen Zhou, Shuqing Han, Zhenyu Kang, Haoyu Chuang, Heng Fan, Hongyang Zhao, Lin Wang, Yunjia Ning, Alexey Sarapultsev, Willis X Li, Jinghong Li, Zhicheng Lin, Shanshan Luo, Nian Xiong, Desheng Hu
Journal: Front Immunol (2021)
Keywords: sars-cov-2, complement system, neurological manifestations, next-generation sequencing, proteomics
MeSH terms: COVID-19 / cerebrospinal fluid, Central Nervous System Diseases / virology, Cerebrospinal Fluid / metabolism, Cerebrospinal Fluid / virology, RNA, Viral / cerebrospinal fluid, Research Support, Non-U.S. Gov't, Adult, Aged, Aged, 80 and over, Female, High-Throughput Nucleotide Sequencing, Humans, Male, Middle Aged, Proteomics, SARS-CoV-2, Sequence Analysis, RNA, RNA, Viral

The SARS-CoV-2 and its variants are still hitting the world. Ever since the outbreak, neurological involvements as headache, ageusia, and anosmia in COVID-19 patients have been emphasized and reported. But the pathogenesis of these new-onset neurological manifestations in COVID-19 patients is still obscure and controversial. As difficulty always lay in the diagnosis of neurological infection, current reports to validate the presence of SARS-CoV-2 in cerebrospinal fluid (CSF) almost relied on the basic methods and warranted improvement. Here we reported a case series of 8 patients with prominent new-onset neurological manifestations, who were screened out from a patch of 304 COVID-19 confirmed patients. Next-generation sequencing (NGS) and proteomics were conducted in the simultaneously obtained CSF and serum samples of the selected patients, with three non-COVID-19 patients with matched demographic features used as the controls for proteomic analysis. SARS-CoV-2 RNA was detected in the CSF of four COVID-19 patients and was suspicious in the rest four remaining patients by NGS, but was negative in all serum samples. Proteomic analysis revealed that 185 and 59 proteins were differentially expressed in CSF and serum samples, respectively, and that only 20 proteins were shared, indicating that the proteomic changes in CSF were highly specific. Further proteomic annotation highlighted the involvement of complement system, PI3K-Akt signaling pathway, enhanced cellular interaction, and macrophages in the CSF proteomic alterations. This study, equipped with NGS and proteomics, reported a high detection rate of SARS-CoV-2 in the CSF of COVID-19 patients and the proteomic alteration of CSF, which would provide insights into understanding the pathological mechanism of SARS-CoV-2 CNS infection.
The Tree Drought Emission MONitor (Tree DEMON), an innovative system for assessing biogenic volatile organic compounds emission from plants
Authors: Marvin Lüpke, Rainer Steinbrecher, Michael Leuchner, Annette Menzel
Journal: Plant Methods (2017)
Keywords: bvoc, castanea sativa mill, drought, dynamic chambers, monoterpene, sweet chestnut

Background:
Biogenic volatile organic compounds (BVOC) emitted by plants play an important role for ecological and physiological processes, for example as response to stressors. These emitted compounds are involved in chemical processes within the atmosphere and contribute to the formation of aerosols and ozone. Direct measurement of BVOC emissions requires a specialized sample system in order to obtain repeatable and comparable results. These systems need to be constructed carefully since BVOC measurements may be disturbed by several side effects, e.g., due to wrong material selection and lacking system stability.
Results:
In order to assess BVOC emission rates, a four plant chamber system was constructed, implemented and throughout evaluated by synthetic tests and in two case studies on 3-year-old sweet chestnut seedlings. Synthetic system test showed a stable sampling with good repeatability and low memory effects. The first case study demonstrated the capability of the system to screen multiple trees within a few days and revealed three different emission patterns of sweet chestnut trees. The second case study comprised an application of drought stress on two seedlings compared to two in parallel assessed seedlings of a control. Here, a clear reduction of BVOC emissions during drought stress was observed.
Conclusion:
The developed system allows assessing BVOC as well as CO2 and water vapor gas exchange of four tree specimens automatically and in parallel with repeatable results. A canopy volume of 30 l can be investigated, which constitutes in case of tree seedlings the whole canopy. Longer lasting experiments of e.g., 1-3 weeks can be performed easily without any significant plant interference.
Case study: chronic recurrent multifocal osteomyelitis in the femoral diaphysis of a young female
Authors: Jeffrey S Quon, Anne K Dzus, David A Leswick
Journal: Case Rep Radiol (2012)
MeSH terms: Case Reports

Chronic recurrent multifocal osteomyelitis (CRMO) is relatively uncommon. Even though the name suggests it is the result of infection, this is not likely the case. Instead it is more likely the result of genetic, autoimmune, or autoinflammatory causes. Although CRMO has a benign course and responds well to anti-inflammatory medications, it can have a very aggressive clinical and imaging presentation overlapping with infectious osteomyelitis and malignancy. Therefore, radiologists and clinicians need to be aware of its clinical and imaging presentation to avoid morbidity associated with more aggressive treatment. We present the case of a ten-year-old female with CRMO as a solitary expansile-mixed lytic and sclerotic lesion in the distal femoral diaphysis. The diaphyseal location and mixed lytic and sclerotic appearance are less common and have an aggressive imaging appearance. We also review the pathophysiology, imaging findings, and therapeutic approach to this uncommon but clinically important condition.
An alternative surgical procedure for a patient with critically restenosed and kinked carotid artery: graft interposition
Authors: Haydar Yaşa, Ovünç Aslan, Barçın Ozcem, Muhammet Akyuz, Ali Gürbüz, Galip Akhan
Journal: Case Rep Surg (2011)
MeSH terms: Case Reports

According to the literature data, the prevalence of restenosis after carotid endarterectomy ranges between 6 and 36%. The etiological factor is intimal hyperplasia for early period, whereas it is atherosclerosis for late period. A 67-year-old male patient admitted to our clinic with a history of headache and minor stroke. His medical history was significant for right carotid endarterectomy 8 years ago. Recent Doppler ultrasound and digital substraction angiography revealed 75% stenosis and kinking corresponding to the segment distal to the endarterectomy region. Surgical endarterectomy is the treatment of choice in critical carotid stenosis. Endovascular therapy is primarily considered for patients if there is restenosis after carotid endarterectomy. However, the treatment modality is controversial in cases with concomitant carotid stenosis and kinking of internal carotid artery. We present our surgical approach to a case with significant stenosis and kinking of internal carotid artery. We performed a 6-mm-PTFE graft interposition between common and internal carotid artery and resection of the kinking segment.
Incidence of injury and illness during the 2013 world dwarf games
Authors: Mathew R Saffarian, Jensen J Swampillai, Michael T Andary, Jim R Sylvain, Salina E Halliday, Brian Bratta
Journal: Inj Epidemiol (2019)
Keywords: achondroplasia, athletics, dwarfism, exercise, skeletal dysplasia, sports, world dwarf games

Background:
Dwarfism, or skeletal dysplasia, is a term used to describe short stature. Injuries to athletes with disabilities and medical co-morbidities, such as those present in the dwarf population, can have significant consequences on functionality. The main objectives of this retrospective descriptive study were to 1) evaluate the safety of athletic participation among athletes with skeletal dysplasia, 2) investigate the incidence and characteristics of injuries and illnesses among athletes with skeletal dysplasia during the 2013 World Dwarf Games held on the campus of Michigan State University, 3) describe details and overview of the World Dwarf Games, and 4) identify possible safety and rule issues to improve safety at future World Dwarf Games.
Methods:
This was a retrospective review of case series interactions between dwarf athletes and the medical staff present at the 2013 World Dwarf games from August 3-10, 2013. Injury incidence rates were calculated by dividing the number of incident injuries by total athlete-competitions. Epidemiologic incidence proportion calculations were used to measure average injury risks.
Results:
A total of 24 competition related injuries were recorded among the 409 athletes. Only 1 illness (otitis media) was reported during the week of games. The overall injury incidence rate was found to be 0.78 injuries per 100 athlete-competitions. The overall epidemiologic incidence proportion was 5.9% (7.2% for males, 3.0% for females). The most common type of injury was a muscle/tendon strain (41.7% of all injuries). The sport with the most reported injuries was soccer with 4.63 injuries per 100 athlete-competitions.
Conclusions:
Based on the data collected, it does appear that athletes with skeletal dysplasia can safely participate in the events offered during the World Dwarf Games. None of the reported injuries or illnesses precluded the athletes from returning to play. Data collected at future competitions will help identify trends, which may lead to rule changes to improve safety and a decrease in injuries. Adding a designated spectator area for athletes as well as modifying rules to prevent excessive physical contact in soccer and basketball competitions may reduce the incidence of injury.
Case Report: Lupoid cutaneous leishmaniasis mimicking verruca plana
Authors: Emin Ozlu, Aysegul Baykan, Ozan Yaman, Ragıp Ertas, Mustafa Atasoy, Kemal Ozyurt, Abdullah Turasan, Nazan Taslıdere
Journal: F1000Res (2017)
Keywords: diagnosis, leishmaniasis, viral disease

Cutaneous leishmaniasis (CL) is an infectious disease caused by various species of leishmania protozoan parasites. Lupoid CL is a rare form of CL that has a stunning similarity to other granulomatous cutaneous conditions of infectious or inflammatory origin. Verruca plana, also known as a "flat wart", is a benign proliferation of the skin resulting from infection with human papilloma virus (HPV). Herein, we presented a case of lupoid CL mimicking verruca plana on the face.
Case Report: Clinical Responses to Tislelizumab as a First-Line Therapy for Primary Hepatocellular Carcinoma With B-Cell Indolent Lymphoma
Authors: Qijun Li, Yong Dong, Yubin Pan, Honglin Tang, Da Li
Journal: Front Immunol (2021)
Keywords: b-cell indolent lymphoma, case report, double primary tumors, hepatocellular carcinoma, immune checkpoint inhibitors, misdiagnosis, tislelizumab
MeSH terms: Antibodies, Monoclonal, Humanized / therapeutic use, Carcinoma, Hepatocellular / drug therapy, Immune Checkpoint Inhibitors / therapeutic use, Liver Neoplasms / drug therapy, Lymphoma, B-Cell / drug therapy, Neoplasms, Multiple Primary / drug therapy, Case Reports, Research Support, Non-U.S. Gov't, Review, Carcinoma, Hepatocellular / diagnostic imaging, Carcinoma, Hepatocellular / immunology, Carcinoma, Hepatocellular / metabolism, Humans, Liver Neoplasms / diagnostic imaging, Liver Neoplasms / immunology, Liver Neoplasms / metabolism, Lymphoma, B-Cell / diagnostic imaging, Lymphoma, B-Cell / immunology, Lymphoma, B-Cell / metabolism, Male, Middle Aged, Neoplasms, Multiple Primary / diagnostic imaging, Neoplasms, Multiple Primary / immunology, Neoplasms, Multiple Primary / pathology, Treatment Outcome, Antibodies, Monoclonal, Humanized, Immune Checkpoint Inhibitors, tislelizumab

Background:
As an emerging therapy with a promising efficacy, immunotherapy has been widely used in the treatment of solid tumors and hematologic malignancies. This clinical study compares the efficacy of tislelizumab, a domestic immune checkpoint inhibitor (ICI), to that of sorafenib when used as a first-line therapeutic option in hepatocellular carcinoma (HCC), and the concurrence of HCC and non-Hodgkin's lymphoma (NHL) is rare, especially in the treatment of ICIs.
Case presentation:
A 61-year-old patient presenting with primary HCC and indolent B-cell lymphoma had a partial clinical response to tislelizumab for his primary HCC. Besides, we described a phenomenon of pseudo-progression and delayed diagnosis of his lymphoma during a long course of treatment.
Conclusion:
Tislelizumab, an immunotherapeutic option with a favorable efficacy and toxicity, can be used to manage double primary tumors. However, studies should aim to elucidate the probable mechanisms of this therapy. Pseudo-progression and separation remission make the treatment of double primary tumors even more challenging, which calls for additional caution in patients undergoing immunotherapy to avoid misdiagnosis and, therefore, begin early appropriate interventions.
Acute Failure of a Glenoid Component in Anatomic Shoulder Arthroplasty
Authors: William E Daner Iii, Norman D Boardman Iii
Journal: Case Rep Orthop (2016)

Glenoid loosening is the most common cause of failure in primary total shoulder arthroplasty (TSA) and often occurs years after the initial surgery. It is rare for a glenoid component to fail acutely. Several case reports of complete glenoid dissociation appear in the literature. It is important to report these failures to identify technical errors or component design flaws to improve outcomes in TSA. In this case report, we present an unrecognized acute failure of a cemented hybrid glenoid component at the time of surgery.
Case Report: Acute Fulminant Myocarditis and Cardiogenic Shock After Messenger RNA Coronavirus Disease 2019 Vaccination Requiring Extracorporeal Cardiopulmonary Resuscitation
Authors: Yongwhan Lim, Min Chul Kim, Kye Hun Kim, In-Seok Jeong, Yong Soo Cho, Yoo Duk Choi, Jong Eun Lee
Journal: Front Cardiovasc Med (2021)
Keywords: covid-19, case report, extracorporeal membrane oxygenation, fulminant myocarditis, vaccination
MeSH terms: Case Reports

Recently, myocarditis following messenger RNA (mRNA) coronavirus disease 2019 (COVID-19) vaccination has become an important social issue worldwide. According to the reports so far, myocarditis related to mRNA COVID-19 vaccination is rare and usually associated with a benign clinical course without intensive care or any sequelae of fulminant myocarditis. Here, we report a case of acute fulminant myocarditis and cardiogenic shock after the mRNA COVID-19 vaccination, requiring extracorporeal cardiopulmonary resuscitation. Clinicians should keep in mind the possibility of progression to fulminant myocarditis in patients who presented with suggestive symptoms or signs of myocarditis after the COVID-19 vaccination.
Persistent Type I Endoleak after Endovascular Treatment with Chimney Technique
Authors: Ana Isabel Azevedo, Pedro Braga, Alberto Rodrigues, Nuno Ferreira, Marlene Fonseca, Adelaide Dias, Vasco Gama Ribeiro
Journal: Front Cardiovasc Med (2016)
Keywords: aortic dissection, endoleak, endovascular aortic repair, endovascular intervention, vascular complications
MeSH terms: Case Reports

Thoracic endovascular aortic repair (TEVAR) is increasingly used in the treatment of acute type B aortic dissection. Type Ia endoleaks are a common complication of the procedure, but its clinical significance and the best treatment strategy remain poorly defined. We present a case of a type Ia endoleak following TEVAR in the treatment of acute type B aortic dissection. Chimney technique approach was used in an attempt to seal the endoleak. Although technical success was suboptimal, the patient remained clinically stable and event free. Data regarding the natural course and management of type Ia endoleaks following TEVAR for aortic dissection are sparse. Future research is required to establish the clinical and technical determinants of the need to treat these endoleaks and the best treatment strategy.
The Third Finger Middle Phalanx Maturation (MPM) Method to Assess Timing of Functional Treatment for Skeletal Class II Malocclusion: Report of Three Cases
Authors: Giuseppe Perinetti
Journal: Case Rep Dent (2019)
MeSH terms: Case Reports

A deficient mandibular growth on the sagittal plane is the most frequent diagnostic finding in dentoskeletal Class II malocclusion. Evidence indicated that functional treatment for such malocclusion is efficient only if performed during the pubertal growth spurt, as identified through radiographical growth indicators. With the aim of reducing the radiation to the patients and to follow longitudinally individual growth phases, the use of the sole third finger middle phalanx maturation (MPM), as a 5-stage method, has been proposed. Herein, three clinical cases of skeletal Class II malocclusion in growing patients treated by removable functional appliances (with or without full-fixed appliance treatment) are reported. Timing of intervention was strictly planned according to the MPM method, and skeletal effects have been recorded up to 21 months of follow-up. In all the cases, noteworthy skeletal effects have been achieved in terms of mandibular elongation, with relevant occlusal and aesthetic outcomes. It has also been showed that results are stable or slightly improved after functional treatment. These results would be achieved irrespective of the appliance used and support the use of the MPM method in everyday clinical practice.
Hemangiopericytoma of the spleen: unusual presentation as multiple abscess
Authors: Mukesh Kumar, Kamlakar Tripathi, Rahul Khanna, Mohan Kumar, Ajay K Khanna
Journal: World J Surg Oncol (2005)

Background:
Hemangiopericytoma is a soft tissue vascular neoplasm arising from capillary pericytes and is found throughout the body in soft tissues and bone. It was first described in 1942. Primary vascular neoplasm of the spleen constitutes the majority of nonhaematolymphoid splenic tumors like haemangioma, lymphangioma, hemangioendothelioma, hemangiopericytoma etc. Splenic hemangiopericytoma is a rare tumor and probably first case was described in 1989. Uptill now only eight cases are reported in the English literature.
Case presentation:
A-35-year old male presented with fever and dull aching pain in left hypochondriac region. Radiological evaluation showed presence of multiple abscesses in spleen. Investigations were done to rule out common causes of abscess in spleen. After failure of medical management, he was subjected to elective splenectomy. There were dense adhesions between the spleen and the adjacent structures and the diaphragm. The histopathology of the resected specimen showed hemangiopericytoma of spleen.
Conclusion:
The present case illustrate that the hemangiopericytoma of spleen can mimic as multiple abscess. Splenectomy is the treatment of choice.
Contralateral Traumatic Hemopneumothorax
Authors: Quevedo-Florez Leonardo Alexander, Montenegro-Apraez Alvaro Andrés, Aguiar-Martinez Leonar Giovanni, Hernández Juan Carlos, Cortés-Tascón Juan David
Journal: Case Rep Emerg Med (2018)
MeSH terms: Case Reports

Pneumothorax is the entry of air into the virtual space between the visceral and the parietal pleurae, which can occur spontaneously or to a greater extent in a traumatic way. In daily clinical practice it is frequent to find injuries that generate traumatic pneumothorax that is ipsilateral to the lesion. However, there are case reports of contralateral pneumothorax that occurred in procedures such as insertion of pacemakers, or in cases of pneumonectomy. The following is the case report of a 37-year-old man who was admitted with a sharp wound to the right paravertebral region who developed a left haemopneumothorax due to a tangential course of the injuring agent. Adequate clinical judgment was followed, and several imaging studies were carried out, leading to the diagnosis of traumatic pneumothorax that was contralateral to the described injury.
Case Report: Changes of Vascular Reactivity and Arterial Stiffness in a Patient With Covid-19 Infection
Authors: Philipp Jud, Harald H Kessler, Marianne Brodmann
Journal: Front Cardiovasc Med (2021)
Keywords: covid-19, arterial stiffness, endothelial dysfunction, vascular reactivity, vasculopathy
MeSH terms: Case Reports

Covid-19 infection may be associated with a higher incidence developing cardiovascular complications, however, the underlying mechanisms contributing to cardiovascular complications are largely unknown, while endothelial cell damage may be present. We want to report a 24-year-old woman with Covid-19 infection who had undergone measurements of vascular reactivity and arterial stiffness, including flow-mediated dilation (FMD), nitroglycerin-mediated dilation (NMD), aortic pulse wave velocity (PWV), augmentation index and carotid intima-media-thickness (cIMT) at the time when Covid-19 was diagnosed. Reduced FMD of 0.0% and NMD of 15.5% were observed, while PWV (5.9 m/s), Aix (27%) and cIMT with 0.4 mm of both common carotid arteries were unremarkable. Repeated measurements of FMD, NMD, PWV, Aix, and cIMT 6 weeks after Covid-19 infection revealed persistently reduced FMD (0.0%), while NMD (17.24%), PWV (5.6 m/s) and augmentation index (13%) ameliorated. This case suggests potential impact of Covid-19 infection on endothelial function, also in young Covid-19 patients without any co-morbidity.