OpenMed/multicare-articles huggingface dataset:
Case report: Surgical treatment of McCune-Albright syndrome with hyperthyroidism and retrosternal goiter: A case report and literature review
Authors: Zhiwei Xing, Gongshuai Tao, Wanwan Pan, Delin Wu, Tingting Pan, Lingfeng Wan, Xiaopeng Ma, Yangyi Wang
Journal: Front Surg (2023)
Keywords: 131i treatment, mccune albright syndrome, case report, hyperthyroidism, retrosternal goiter, thyroidectomy
MeSH terms: Case Reports

Introduction:
McCune-Albright syndrome (MAS) is a low-incidence syndrome consisting of the clinical triad of fibrous structural dysplasia of bone, endocrine disease, and skin pigmentation. Thyroid dysfunction is the second most common endocrine dysregulation in MAS. However, there are no treatment guidelines for MAS complicated with hyperthyroidism. Notably, no case of MAS complicated with retrosternal goiter and hyperthyroidism has been reported to our knowledge.
Case presentation:
We report a 27-year-old man with MAS who developed the typical triad of bone fibrous dysplasia, skin pigmentation and hyperthyroidism, complaining of recent fast-growing neck mass and difficulty in breathing. Hyperthyrodism was under control by Thiamazole, and computed tomography showed an enlarged thyroid extending retrosternally. We performed a total thyroidectomy on the patient. At the 1-year follow-up, the patient's dyspnea, hyperthyroidism, and bone pain were all significantly alleviated.
Review:
We searched the literature for previous case reports concerning MAS patients complicated with thyroid dysregulation. A total of 17 articles and 22 patients were identified to form our database. Among them, 9 studies clearly mentioned surgical intervention in 11 patients, and prognoses were also reported. Surgery was the most common intervention chosen and indicated a satisfactory prognosis.
Conclusion:
We report a rare case of MAS patient complicated with retrosternal goiter and hyperthyroidism. Our review provides an overview of MAS cases requiring interventions on thyroid function, and total thyroidectomy should be a proper treatment for these patients.
Dynamic Contrast Enhanced MRI Can Monitor the Very Early Inflammatory Treatment Response upon Intra-Articular Steroid Injection in the Knee Joint: A Case Report with Review of the Literature
Authors: Mikael Boesen, Olga Kubassova, Marco A Cimmino, Mikkel Ostergaard, Peter Taylor, Bente Danneskiold-Samsoe, Henning Bliddal
Journal: Arthritis (2011)

Dynamic contrast-enhanced MRI in inflammatory arthritis, especially in conjunction with computer-aided analysis using appropriate dedicated software, seems to be a highly sensitive tool for monitoring the early inflammatory treatment response in patients with rheumatoid arthritis. This paper gives a review of the current knowledge of the emerging technique. The potential of the technique is demonstrated and discussed in the context of a case report following the early effect of an intra-articular steroid injection in a patient with rheumatoid arthritis flare in the knee.
Coexistence of granular cell tumor with squamous cell carcinoma on the tongue: a case report
Authors: Recep Bedir, Rukiye Yilmaz, Ibrahim Sehitoglu, Abdulkadir Ozgur
Journal: Iran J Otorhinolaryngol (2015)
Keywords: granular cell tumor, immunohistochemistry, squamous cell carcinoma, tongue
MeSH terms: Case Reports

Introduction:
Granular cell tumors (GCTs) are rare and mostly benign soft tissue tumors. Though they have been reported in all parts of body, they are generally located in the head and neck region, especially on the tongue. Some malign forms exist, but these have been rarely reported. Granular cell tumors have a neural origin and, in immunohistochemical evaluations, they express S-100 and neuron specific enolase (NSE). The treatment of these tumors is bulky surgical excision.
Case report:
In this case, a cauliflower shaped lesion with a 1 cm diameter was excised from the midline tongue of a 65 year old woman. The histopathological evaluation indicated that it was squamous cell carcinoma (SCC) covering GCT. Herein, the coexistence of GCT and SCC we describe on the same region of the tongue, in accordance with literature review, since this is a very rare condition.
Conclusion:
Pseudoepitheliomatous hyperplasia may accompany GCTs on the tongue and this condition may mimic well-differentiated SCC. For this reason, with the help of Ki-67 and p63 expression, in addition to immunohistochemical markers, well-differentiated SCC should be differentiated from pseudoepitheliomatous hyperplasia through careful investigation.
Case Report: Solitary Extramedullary Plasmacytoma in the Cervix Misdiagnosed as Cervical Cancer
Authors: Ji Wang, Lin Jiang, Xuejin Ma, Tingchao Li, Heng Liu, Xiaoxi Chen, Shiguang Li
Journal: Front Oncol (2021)
Keywords: mri, case report, cervical cancer, solitary extramedullary plasmacytoma, solitary plasmacytoma
MeSH terms: Case Reports

Solitary plasmacytoma (SP) is a malignant tumor caused by the monoclonal proliferation of plasma cells, representing less than 5% of plasma cell tumors. SP can be categorized into two groups: solitary bone plasmacytoma (SBP) and solitary extramedullary plasmacytoma (SEP). SEP most commonly occurs in the head and neck and is rarely located in the reproductive system. Here, we report a case of a 77-year-old woman with SEP in the cervix who had a 7-day history of vaginal bleeding. Ultrasonography and magnetic resonance imaging (MRI) showed an oval mass in the cervix, which was initially considered as neoplastic lesions and highly suspected to be cervical cancer, but cervical leiomyoma and other benign tumors cannot be completely excluded. Subsequently, cervical biopsy showed that the tumor was SEP, and then the patient underwent surgery. The postoperative pathological diagnosis was also SEP, which confirmed the radiologist's misjudgment. In conclusion, SEP that occurs in the cervix is remarkably rare, and only nine cases have been reported in the cervix. No case reports to date have described in detail the imaging findings of cervical SEP. This study demonstrates the MRI imaging characteristics of a patient with SEP of the cervix and reviews the imaging findings of SEP reported in the previous literature, in order to provide more extensive insights for radiologists to consider the differential diagnosis of cervical lesions.
Case report: COPA syndrome with interstitial lung disease, skin involvement, and neuromyelitis spectrum disorder
Authors: Xiao Li, Yu Tang, Lei Zhang, Yuan Wang, Weihua Zhang, Ying Wang, Yuelin Shen, Xiaolei Tang
Journal: Front Pediatr (2023)
Keywords: children, copa syndrome, neuromyelitis optica spectrum disorder, rashes, sirolimus
MeSH terms: Case Reports

This report describes a case of a 22 months Chinese boy with COPA syndrome bearing the c.715G > C (p.A239P) genotype. In addition to interstitial lung diseae, he also suffered from recurrent chilblain-like rashes, which has not been previously reported, and neuromyelitis optica spectrum disorder (NMOSD), which is a very rare phenotype. Clinical manifestations expanded the phenotype of COPA syndrome. Notably, there is no definitive treatment for COPA syndrome. In this report, the patient has achieved short-term clinical improvement with sirolimus.
Case Report: Evidence of Migratory Silicone Particles Arising From Cohesive Silicone Breast Implants
Authors: Jessica C R Mustafá, Eduardo de Faria Castro Fleury, Henry B P M Dijkman
Journal: Front Glob Womens Health (2022)
Keywords: cohesive silicone gel, histology, non-cohesive silicone gel, silicone breast implant, silicone gel bleed, silicone migration
MeSH terms: Case Reports

Background:
Silicone implants have been used since the 1960s for aesthetic purposes and breast reconstructions. During this period, many women have reported up to 40 similar symptoms, including fatigue, the emergence of autoimmune diseases, Raynaud Phenomenon, arthritis, arthralgias, and hair loss, among others. However, most of the time, these symptoms are neglected by doctors across different specialties and are most often considered a psychosomatic disease. Since 2017, many women suffering from the same complaints have formed social media groups to report their histories and subsequently describe the disease as Breast Implant Illness (BII). The phenomenon of gel bleed and silicone toxicity is known and accepted in literature, but silicone migration into the extracapsular space is still poorly demonstrated, due to the difficulty of monitoring its particles and access to patient data.
Methods:
This work demonstrated the presence of silicone through pathological examination in post-explant breast capsules and in the synovial tissue of the right wrist, detected with special Modified Oil Red O (MORO) staining in a patient with a history of BII. The pathological results were compared to the breast MRI imaging files.
Results:
The MRI images show the permeability change of the implant shell diagnosed as a water-droplet signal. It was also possible to diagnose the gel bleeding as the silicone-induced granuloma of breast implant capsule (SIGBIC) in both implants. Silicone gel bleed and migration of silicone were detected with MORO staining in and outside the capsule and in the synovial tissue of the right wrist.
Conclusion:
In this case study, we showed that silicone migration is possible via cohesive silicone gel breast implant leakage. The accumulation of silicone in the synovial tissue of the right wrist suggests local silicone toxicity and defects.
Thrombotic Microangiopathy Secondary to Intravenous Abuse of Opana® ER
Authors: Kamia Thakur, Vaibhav Agrawal, Ashley Kass, Lauren M Dimarino, R Patrick Dorion, Joseph Vadakara
Journal: Case Rep Hematol (2017)
MeSH terms: Case Reports

Opana ER (oxymorphone) is an opioid drug available throughout the United States, and intravenous abuse of the crushed oral formulation has been associated with drug-induced thrombotic microangiopathy. In this abstract, we describe two young patients who lived together and used Opana ER intravenously. Both presented with microangiopathic hemolytic anemia that mimicked thrombotic thrombocytopenic purpura (TTP). Treating this condition poses a clinical challenge, as it is difficult to distinguish it from TTP. The role for plasma exchange is not clear but can be used while awaiting the results of the ADAMTS-13 activity, but ultimately supportive care with drug discontinuation is the recommended therapy of choice. Patients should be counseled against Opana ER's intravenous use, and users should be offered drug rehabilitation therapy.
Granulocytic Sarcoma of the Stomach Presenting as Dysphagia during Pregnancy
Authors: Anuradha Sekaran, Santosh Darisetty, Sandeep Lakhtakia, Mohan Ramchandani, Duvuru Nageshwar Reddy
Journal: Case Rep Gastrointest Med (2011)
MeSH terms: Case Reports

Granulocytic sarcoma also known as extramedullary myeloid sarcoma or chloroma is an uncommon manifestation of leukemia and presents as a deposit of leukemic cells outside the bone marrow. We report a case of a twenty-five-year-old pregnant woman who presented with progressive dysphagia and recurrent postprandial vomiting. Upper GI endoscopy had shown large flat laterally spread nodular lesions in the cardia and proximal body of stomach. Biopsies from the gastric lesion showed granulocytic sarcoma of the stomach. Concurrent peripheral and bone marrow picture was suggestive of acute myeloid leukemia (AML-M4). There is limited reported literature on granulocytic sarcoma of the stomach. Concurrent gastric granulocytic sarcoma involving cardia and AML in pregnancy has not been reported till date.
Conservative approach in patients with pemphigus gingival vulgaris: a pilot study of five cases
Authors: Alessio Gambino, Mario Carbone, Paolo G Arduino, Paola Carcieri, Lucio Carbone, Roberto Broccoletti
Journal: Int J Dent (2014)

Objectives. The aim of this pilot study was to describe the clinical efficacy of a conservative oral hygiene protocol in patients affected by gingival pemphigus vulgaris (PV) applied in a case series. Methods. Subjects suffering from PV with gingival localisation and slightly responsive to conventional treatment with systemic corticosteroids and immunosuppressive drugs were selected among individuals treated in the Unit of Oral Medicine Section of the University of Turin. Five subjects received nonsurgical periodontal therapy, over a 7-day period, including oral hygiene instructions; patients were instructed about domiciliary oral hygiene maintenance and instructions were reinforced at each visit and personalised if necessary. Clinical outcome variables were recorded at baseline (before starting) and 16 weeks after intervention, including full mouth plaque score (FMPS), bleeding scores (FMBS), probing pocket depth (PPD), oral pemphigus clinical score (OPCS), and patient related outcomes (visual analogue score of pain). Results. Five patients were treated and, after finishing the proposed therapy protocol, a statistical significant reduction was observed for FMBS (P = 0.043) and OPCS (P = 0.038). Conclusions. Professional oral hygiene procedures with nonsurgical therapy are related to an improvement of gingival status and a decrease of gingival bleeding in patients affected by PV with specific gingival localization.
Coronary arteriovenous fistula secondary to percutaneous coronary intervention of chronic total occlusion
Authors: Seshasayee Narasimhan
Journal: Case Rep Vasc Med (2013)

This is a case report of a 61-year-old female presenting with ongoing chest pain in the setting of an NSTEMI with lateral ST-T changes. On attempting to open the left circumflex (LCX), it resulted in a proximal LCX dissection. The patient remained stable with no further chest pain. She was treated with IV Eptifibatide for 48 hours and restudied in 72 hours. Repeat coronary angiography showed a marginally improved proximal dissection plane with a coronary AV fistula. She was managed conservatively and discharged with a non-invasive assessment in 8 weeks. The patient had a negative stress echocardiogram and was managed with maximal medical therapy.
Breast metastatic localization of signet-ring cell gastric carcinoma
Authors: C Parrell Soler, A Palacios Marqués, L Saco López, R Bermejo De Las Heras, S Pertusa Martínez
Journal: ISRN Obstet Gynecol (2011)
MeSH terms: Case Reports

Metastatic tumors in the breast are quite rare and constitute 0,5 to 6% of all breast malignancies. They often occur in a polymetastatic context. Gastrointestinal lesions rarely metastasize to the breast. The first case of a metastasis deposit to the breast and ovary from gastric signet-ring cell carcinoma was reported in the literature in 1999. Since this report, only 5 cases have been reported. We present a case report of a 37-year-old woman who complained of a lump in the left breast. Two months earlier, the woman underwent a subtotal gastrectomy and a total hysterectomy with double anexectomy, which histologically was diagnosed of gastric signet-ring carcinoma, disseminated with Krukenberg's tumor. In those days, the patient was following a chemotherapy treatment. A core needle biopsy of the lesion in left breast revealed cells with signet-ring features, with probably gastric origin.
Clear Cell Myoepithelial Carcinoma Arising from the Hard Palate with Metastasis to the Lungs
Authors: Jiayun Fang, Amanda Kornfield, Alex Clavijo, Shikhar Vyas, Alison Ulbrandt, Carsten Schroeder, J Kenneth Byrd, Daniel Kleven
Journal: Case Rep Pathol (2019)
MeSH terms: Case Reports

Myoepithelial carcinoma is an uncommon tumor of the salivary glands, most commonly the parotid gland. Clear cell myoepithelial carcinoma is a rare variant with an aggressive behavior. Here, we describe a case of clear cell myoepithelial carcinoma arising from the hard palate in an elderly male who underwent resection of the tumor and postop radiation. Posttreatment imaging demonstrated bilateral pulmonary nodules and a C2 body lesion concerning for metastasis. Biopsy of the lung lesions revealed a monomorphous population of optically clear cells with hyperchromatic and pleomorphic nuclei which were morphologically similar to the prior resection specimen. There are few reported cases of clear cell myoepithelial carcinoma arising from the hard palate, and there are even fewer reports on metastases to the lungs. Due to the low number of reported cases, prognosis and treatment of this neoplasm is not well defined.
Anesthetic management of a child with Apert syndrome
Authors: Yavor Metodiev, Nadezhda Gavrilova, Atanas Katzarov
Journal: Saudi J Anaesth (2011)
Keywords: apert syndrome, axillary block, transversus abdominis plane block, ultrasound guidance
MeSH terms: Case Reports

In this paper, the authors describe an anesthetic technique for a child with Apert syndrome, presenting to the operating room for a syndactyly separation. The anesthetic approach is innovative for the clinic and is a combination of intravenous anesthesia and two regional techniques (axillary block and transversus abdominis plane block, respectively). They were performed under ultrasound guidance and provided analgesia in the two body regions, which were to be operated.
New psychoactive substance α-PVP in a traffic accident case
Authors: Sebastian Rojek, Karol Kula, Martyna Maciów-Głąb, Małgorzata Kłys
Journal: Forensic Toxicol (2016)
Keywords: druid, new psychoactive substances (npss), psychological symptoms, traffic accident, α-pyrrolidinovalerophenone (α-pvp)

The problems of new psychoactive substances (NPSs), especially related to drivers, constitute an open research area. In this case report, we present a traffic accident case, in which two passengers of five individuals died instantly, while the other three persons survived the accident with minor injuries only. From the blood samples of the driver and the passengers, α-pyrrolidinovalerophenone (α-PVP), an NPS belonging to the category of cathinone derivatives, was disclosed. Therefore, we established a detailed procedure for analysis of α-PVP in blood samples by liquid chromatography-tandem mass spectrometry. After careful validation tests of this method, α-PVP concentration in blood samples from the surviving driver and passengers, and from the two deceased, were measured. The concentrations varied from 20 to 650 ng/mL. Access to detailed information originating from the court files and from explanations provided by the driver and eye witnesses revealed extremely valuable illustrative details addressing the symptoms and pharmacological effects of α-PVP on the human organism, thus contributing to enriching the body of knowledge of α-PVP abuse.
A Novel Probable Pathogenic PSEN2 Mutation p.Phe369Ser Associated With Early-Onset Alzheimer's Disease in a Chinese Han Family: A Case Report
Authors: Ke Wan, Zhen-Juan Ma, Xia Zhou, Yi-Mei Zhang, Xian-Feng Yu, Meng-Zhe You, Chao-Juan Huang, Wei Zhang, Zhong-Wu Sun
Journal: Front Aging Neurosci (2021)
Keywords: psen2, early-onset alzheimer's disease, magnetic resonance imaging, novel pphe369ser mutation, transmembrane domain 7
MeSH terms: Case Reports

The pathogenesis of Alzheimer's disease is complex, and early-onset Alzheimer's disease (EOAD) is mostly influenced by genetic factors. Presenilin-1, presenilin-2 (PSEN2), and amyloid precursor protein are currently known as the three main causative genes for autosomal dominant EOAD, with the PSEN2 mutation being the rarest. In this study, we reported a 56-year-old Chinese Han proband who presented with prominent progressive amnesia, aphasia, executive function impairment, and depression 5 years ago. The 3-year follow-up showed that the patient experienced progressive brain atrophy displayed on magnetic resonance imaging (MRI) and dramatic cognitive decline assessed by neuropsychological evaluation. This patient was clinically diagnosed as EOAD based on established criteria. A heterozygous variant (NM_000447.2: c.1106T>C) of PSEN2 was identified for the first time in this patient and her two daughters. This mutation causing a novel missense mutation (p.Phe369Ser) in transmembrane domain 7 encoded by exon 11 had not been reported previously in 1000Genomes, ExAC, or ClinVar databases. This mutation was predicted by four in silico prediction programs, which all strongly suggested that it was damaging. Our results suggest that this novel PSEN2 Phe369Ser mutation may alter PSEN2 protein function and associate with EOAD.
Lutembacher syndrome presenting as heart failure in a young Nigerian at Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife: a case report
Authors: Opeyemi Ezekiel Ojo, Anthony Olubunmi Akintomide, Rasaaq Ayodele Adebayo, Olumide Akinniyi Akinyele, Ikponmwosa Godfrey Akhionbare, Oyeronke Titilope Williams, Busayo Onafowoke Oguntola, Obafemi Sunday Adesanya, Adebiyi Lukman Obasanjo
Journal: Pan Afr Med J (2022)
Keywords: lutembacher syndrome, case report, heart failure, late presentation, rare case
MeSH terms: Heart Failure / diagnosis, Heart Failure / etiology, Heart Failure / therapy, Heart Septal Defects, Atrial / complications, Heart Septal Defects, Atrial / diagnosis, Hypertension, Pulmonary / diagnosis, Hypertension, Pulmonary / etiology, Lutembacher Syndrome / complications, Lutembacher Syndrome / diagnosis, Mitral Valve Stenosis / complications, Case Reports, Adult, Dyspnea / etiology, Hospitals, Teaching, Humans, Male, Nigeria, Universities

Lutembacher syndrome (LS) is a rare syndrome comprising a combination of atrial septal defect (ASD) and mitral stenosis. We present the case of a 28-year-old man, who presented with progressively worsening dyspnea of 2 months associated with orthopnea, paroxysmal nocturnal dyspnea, bilateral leg swelling and productive cough. Chest X-ray revealed plethoric lung fields with prominent pulmonary conus and cardiomegaly. Transthoracic echocardiography revealed a large ostium secundum ASD with left to right shunt, mild mitral stenosis, severe mitral and tricuspid regurgitations and pulmonary hypertension. A diagnosis of Lutembacher syndrome in heart failure with pulmonary hypertension was made. The patient was managed conservatively, but declined surgery primarily because of financial reasons. This rare case of LS presenting with heart failure and complicated by pulmonary hypertension is the first reported case in our centre and our region. The patient's inability to afford the cost of definitive care posed a significant problem in his management.