OpenMed/multicare-articles huggingface dataset:
Ewing's sarcoma of proximal femur: case report of extreme osteotomy with 3D-printed prosthesis for the reconstruction
Authors: Xiaoying Niu, Wen Tian, Xiaoxiao Liang, Weitao Yao, Peng Zhang
Journal: Front Bioeng Biotechnol (2023)
Keywords: 3d-printed, ewing’s sarcoma, bone tumor, proximal femur, reconstruction
MeSH terms: Case Reports

Background: Resection and reconstruction of malignant bone tumors at the proximal femur in adolescent patients has remained a clinical challenge. Considering the growth and development requirements of adolescents, there is no unified standard for the reconstruction of bone defects at the proximal femur. Here, we report a case of 3D-printed titanium alloy customized prosthesis for the construction of proximal femoral bone defects in an adolescent patient with Ewing's sarcoma of the proximal femur. Case presentation: A 7-year-old female patient presented to a local hospital with left hip pain, and was diagnosed with Ewing's sarcoma on the proximal left femur. The patient received two courses of neoadjuvant chemotherapy before surgery according to the standard protocol. Considering growth and development problems associated with adolescents, we adopted a customized 3D-printed prosthesis of proximal femur for preservation of the femoral head and part of the femoral neck in the affected limb. Clinical outcomes, recorded after 12 months of follow-up, revealed excellent functional recovery and satisfactory functional scores of the affected limb, with no immediate complications. Conclusion: 3D-printed prosthesis is a feasible method for preserving femoral head and reconstruction of bone defects in adolescents' proximal femur.
Takayasu's Arteritis: An Uncommon Cause of Hemorrhagic Stroke in Young Individuals
Authors: Ebad-Ur Rehman Syed, Noman Salih, Hidayat Ullah, Abdul Wahab, Muhammad Younas Ali, Muhammad Ayub, Numan Ghani
Journal: Cureus (2024)
Keywords: aorta, asian woman, cyclophosphamide, ischemic infarcts, neurovascular complications, prednisolone, seizures, takayasu's arteritis, vasculitis
MeSH terms: Case Reports

The aorta is particularly damaged by Takayasu's arteritis (TA), a rare form of vasculitis. Chest discomfort, exhaustion, fever, elevated blood pressure, heart failure, and stroke can all result from this. Major intimal fibrosis with vascular constriction is the disease's hallmark; although anybody can have it, Asian females in their 20s or 30s seem to be most typically affected. The treatment of a 23-year-old Asian female with Takayasu's arteritis (TA) is discussed in this case study, along with her presentation. Before developing seizures, the patient first showed signs of left-sided weakness and facial droop. Ischemic infarcts and vasculopathy were detected by imaging. The patient fulfilled several American College of Rheumatology (ACR) criteria for TA with a positive erythrocyte sedimentation rate (ESR). During treatment, high-dose prednisolone, cyclophosphamide, and neuroprotective measures were used. The patient's attentiveness and mobility improved despite early complications, such as vascular friability. This case illustrates the difficulties and effective treatment of neurovascular problems connected to TA.
Bovine herpesvirus meningoencephalitis in the State of Tocantins, Brazil
Authors: Ilgner Aimar Bezerra Pinheiro, Bianca Pereira Dias, Jardel Martins Ferreira, Alessandro José Ferreira Dos Santos, Sandro Estevan Moron, Gilzelle Maria da Luz Silva, Liana Bezerra Dias de Lima, Fabiano Mendes de Cordova
Journal: Braz J Vet Med (2024)
Keywords: bohv, cattle, herpetic encephalitis, necrotizing meningoencephalitis, neuropathy
MeSH terms: Case Reports

Three outbreaks of herpesvirus meningoencephalitis in cattle have been reported in three municipalities in the northern region of the State of Tocantins, Brazil. In one outbreak, 41 predominantly young bovines were affected, with 2-3 deaths in some cases. The animals showed neurological signs of incoordination, blindness, and recumbency, with death occurring within approximately 4-5 d. At necropsy, hyperemia and leptomeningeal hemorrhages were observed in the brain. Histology revealed more intense lesions in the rostral portions of the brain, mainly affecting the frontoparietal cerebral cortex, with nonsuppurative encephalitis and meningitis, glial nodules, neuronophagia, and eosinophilic intranuclear inclusion bodies in the astrocytes and neurons. This study shows the presence of bovine herpesvirus in Tocantins, probably the highly neurotropic type 5 strain, and emphasizes its importance in the differential diagnosis of bovine neuropathies.
Successful treatment with bortezomib in combination with dexamethasone in a middle-aged male with idiopathic multicentric Castleman's disease: A case report
Authors: Hongling Li, Yang He, Yongying Wang, Mengwei Xu
Journal: Open Med (Wars) (2024)
Keywords: bortezomib, case report, idiopathic multicentric castleman disease, refractory, salvage strategy
MeSH terms: Case Reports

Multicentric Castleman disease (MCD) is a heterogeneous, life-threatening disease. A subgroup of HIV-negative and HHV-8-negative MCD is defined as idiopathic MCD (iMCD) with a poor prognosis. Here we report an unusual case of a 47-year-old male patient with iMCD who experienced multiple treatment regimens such as chemotherapy, immunomodulatory therapy, and targeted therapy, all of which were considered ineffective. Subsequently, he was started on bortezomib in combination with dexamethasone for six cycles and he was in complete remission. The patient has survived nearly 13 years to date - the longest survival of any iMCD patient treated with bortezomib in combination with dexamethasone. Bortezomib combined with dexamethasone may be an effective salvage strategy for severe and refractory iMCD.
Neural leprosy investigation using electroneuromyography and the ML Flow rapid test: a case report
Authors: Roque Rafael de Oliveira Neto, Gabriela Belmonte Dorilêo, Ana Carolina da Silva Ferreira Mendonça, Amílcar Sabino Damazo
Journal: Rev Soc Bras Med Trop (2024)
MeSH terms: Leprosy / diagnosis, Leprosy / pathology, Leprosy, Tuberculoid / pathology, Case Reports, Adult, Humans, Mycobacterium leprae, Skin / pathology

Neural leprosy, which is characterized by nerve involvement without visible skin lesions, presents a diagnostic challenge. This case report examined the significance of diverse diagnostic modalities in the identification of pure neural leprosy. A 28-year-old patient with symptoms of edema, pain, paresthesia, and diminished sensitivity in the lower limbs underwent various tests. A stilt skin smear yielded negative results on bacilloscopy, whereas a Fast ML Flow leprosy test and electroneuromyography supported the diagnosis. This discussion highlights the importance of accessible methods for early investigation. This study emphasizes the multidisciplinary approach and value of the Fast ML Flow leprosy test and electroneuromyography for diagnosing neural leprosy.
Case report: lipoprotein apheresis reduces the risk of cardiovascular events and prolongs pregnancy in a woman with severely elevated lipoprotein(a), cardiovascular disease, and a high risk of preeclampsia
Authors: Joanna Marlȩga-Linert, Katarzyna Wartecka-Zielińska, Dariusz Wydra, Marcin Fijałkowski, Marcin Gruchała, Agnieszka Mickiewicz
Journal: Front Med (Lausanne) (2023)
Keywords: case report, lipoprotein (a), lipoprotein apheresis, preeclampsia, pregnancy
MeSH terms: Case Reports

Background:
Preeclampsia is a common and serious pregnancy-induced disease, with potential severe maternal and fetal complications. Recently, an increased lipoprotein (a) (Lp[a]) concentration, an important factor in cardiovascular diseases (CVDs) pathogenesis, has been identified as a sensitive and specific marker of preeclampsia severity. Although lipoprotein apheresis (LA) is currently used in patients with hyperlipoproteinemia(a) and CVD, real-life data on its efficacy among pregnant women with an increased risk of preeclampsia are limited.
Case presentation:
We present the case of a pregnant woman with severely elevated Lp(a), two previous episodes of the acute coronary syndrome and multivessel coronary disease treated with long-term LA before pregnancy, and a high risk of preeclampsia (as assessed using combined test screening). An increased pulsatility index and early diastolic notch were observed on Doppler interrogation at 18 weeks' gestation. Biweekly LA therapy was re-initiated at 21 weeks' gestation. The LA safely removed 70% of the serum Lp(a) concentration and reduced low-density lipoprotein-cholesterol (LDL-C) levels by 60%. We also observed an improvement in her urine protein/creatinine ratio, a reduction in the pulsatility index, and a notch on Doppler interrogation. The pregnancy lasted until week 36, when severe preeclampsia prompted an emergency cesarean delivery.
Conclusion:
Pregnancy in women with elevated Lp(a), CVD, and a high risk of preeclampsia can present challenges in clinical management. Our case report indicates the benefits of LA in preventing atherosclerotic CVD progression during pregnancy, its potential influence on uteroplacental circulation, and prolongation of pregnancy for the best possible intrauterine fetus development. LA may be considered as a treatment option during pregnancy in such conditions. In addition, in pregnant women with CVD, we suggest screening using a combined test and measurement of Lp(a) as a marker of preeclampsia severity.
An Unusual Case of Peripheral Nerve Vasculitis
Authors: S Wang, Arsany A, D Feinstein, P Traisak, H Eid, M Karpoff
Journal: Case Rep Rheumatol (2024)
MeSH terms: Case Reports

Peripheral neuropathy is a common manifestation of systemic vasculitis. The etiology of vasculitic peripheral neuropathy is generally classified into two groups: systemic and nonsystemic. In systemic vasculitic neuropathy (SVN), neuropathy is a consequence of a systemic disease, most commonly involving medium and small vessels throughout the body. There are three main clinical presentations: multifocal neuropathy, distal symmetric polyneuropathy, and overlapping multifocal neuropathy. Specifically, distal symmetric polyneuropathy affects multiple somatic nerves diffusely in a symmetric and length-dependent pattern (also known as the classic stocking-glove pattern). This case represents an atypical presentation of SVN, presenting with widespread symmetric polyneuropathy.A 73-year-old woman presented with distal acute on chronic bilateral upper and lower extremity weakness, sensory changes, and widespread pain. Symptoms started about three months prior and gradually worsened with progressive difficulty with ambulation and required assistive devices. Elevated ESR is at 70 mm/hour, CRP at 25.66 mg/dL, elevated c-ANCA titers at 1 : 320 and PR3 at 5.0 AI, and elevated creatine kinase (CK) at 500-600 U/L. A muscle biopsy of the left vastus showed neurogenic atrophy without myositis. Initial improvement was with oral prednisone, but was stopped on discharge. Many purpuric and petechial lesions were developed on distal legs/feet and right fourth digit distal gangrene. EMG showed distal, symmetric, and axonal polyneuropathy affecting the upper and lower extremities and acute denervation in more distal muscles. The patient received pulse dose steroids and two doses of rituximab induction therapy and was discharged with an oral steroid taper. The patient's symptoms started as distal symmetric neuropathy at the onset and progressively worsened over the course of 3 months. Neuropathy, both on the exam and on EMG, seemed to have developed more rapidly than expected, regardless of its distribution. The EMG showed severe peripheral nerve damage and denervation, which is unusual for ANCA-associated systemic vasculitis.
Rethinking the MBA through Hip Hop innovation and Hip Hop innovators: Fat Joe and DJ Khaled pair with two sport × entertainment faculty
Authors: C Keith Harrison, Reggie Saunders, Whitney Griffin, Scott Bukstein, Jeffrey Porter, Brandon Martin
Journal: Front Sports Act Living (2024)
Keywords: hip hop, mba program, creativity, ethnic entrepreneurship, innovation, sport management

Theory without relevance for practice in a professional graduate degree has been critiqued by some scholars as a deficit approach when preparing MBA students for the workforce. Scholars and practitioners alike call for more pedagogy in the curriculum with a focus on innovation, creativity, and the involvement of industry practitioners. This paper serves as a case study of a moment in time on Monday, 14 June 2021, when the concept of "pracademics" was realized between two artists and two faculty. Following the transcription of the dialogue between two guest speakers from the Hip Hop world (i.e., Fat Joe and DJ Khaled) and two faculty from the sport management MBA program, the paper analyzes the deeper meaning of their intellectual presence with their expertise in the business of culture (i.e., Hip Hop). Findings reveal how the pairing of Hip Hop artists and faculty in an MBA program can address the innovation gap within global business curricula and models. The broader umbrella of pedagogy and application has implications for other academic disciplines to embrace this concept of pairing academics and industry practitioners.
COVID-19, A New Possible Mimicker of Interstitial Lung Disease Related to Primary Sjögren's Syndrome
Authors: Alessia Laneri, Stefania Cerri, Giovanni Della Casa, Antonio Moretti, Andreina Manfredi, Marco Sebastiani, Enrico Clini, Carlo Salvarani
Journal: Case Rep Med (2023)
MeSH terms: Case Reports

Introduction. Acute exacerbation of interstitial lung disease (ILD) and COVID-19 pneumonia show many similarities, but also COVID-19 sequelae, mainly when fibrotic features are present, can be difficult to distinguish from chronic ILD observed in connective tissue diseases. Case Report. In 2018, a 52-year-old woman, was diagnosed with primary Sjogren's syndrome (pSS). The patient did not show respiratory symptoms, and a chest X-ray was normal. During March 2020, the patient was hospitalized for acute respiratory failure related to COVID-19 pneumonia. Three months later, follow-up chest high-resolution computed tomography (HRCT) showed ground glass opacity (GGO) and interlobular interstitial thickening. Pulmonary function tests (PFTs) showed slight restrictive deficit and mild reduction in diffusion lung of carbon monoxide (DLCO). The patient complained of asthenia and exertional dyspnoea. A multidisciplinary discussion including rheumatologist, pulmonologist, and thoracic radiologist did not allow a definitive differential diagnosis between COVID-19 persisting abnormalities and a previous or new-onset pSS-ILD. A "wait and see" approach was decided, monitoring clinical conditions, PFTs, and chest HRCT over time. Only 2 years after the hospitalization, improvement of clinical symptoms was reported; PFT also improved, and HRCT showed almost complete resolution of GGO and interlobular interstitial thickening, confirming the diagnostic hypothesis of long-COVID lung manifestations. Discussion. In the above-reported case report, 3 differential diagnoses were possible: a COVID-19-related ILD, a preexisting pSS-ILD, or a new-onset pSS-ILD triggered by COVID-19. Regardless of the diagnosis, the persistence of clinical and PFT alterations, suggested a chronic disease but, surprisingly, clinical and radiologic manifestations disappeared 2 years later.
Navigating Idiopathic Masseter Muscle Hypertrophy in a 14-Year-Old Female Child: A Report of a Unique Case
Authors: Chaitanya Kumar Javvaji, Keta Vagha, Jayant D Vagha, Rahul Desale, Punam Uke, Ashish Varma, Anirudh Kommareddy, SreeHarsha Damam, Naramreddy Sudheesh Reddy
Journal: Cureus (2024)
Keywords: benign vascular tumors, botulinum injection, mandible tumor, masseter muscle, parotid tumours, sialography
MeSH terms: Case Reports

This case report documents the clinical journey of a 14-year-old female child experiencing bilateral swelling and pain in the mandibular region, suggestive of idiopathic masseter muscle hypertrophy. This condition, although relatively uncommon, can present itself either unilaterally or bilaterally. While cosmetic concerns, often denoted as a "square face," are commonly expressed by patients, additional symptoms like protrusion, bruxism, or trismus may also be present. The patient reported a gradual and asymptomatic bilateral bulging in the mandible angle region, with an explicit complaint of pain. The physical examination revealed bilateral masseter hypertrophy without accompanying local inflammatory changes. Diagnosing this condition necessitates discerning its characteristics, evaluating clinical and radiographic findings, and excluding more severe pathologies like parotid diseases, lymphangioma, and rhabdomyoma. In cases of diagnostic uncertainty, complementary tests are deemed appropriate. Treatment strategies range from conservative measures to surgical interventions. This investigation aims to fulfill its primary objectives by presenting a case study elucidating the intricacies of idiopathic masseter hypertrophy, detailing associated symptoms, and exploring the spectrum of potential treatment options. Through this exploration, we contribute to the evolving understanding and management of this unique condition, especially within the pediatric age group.
Case Report: Can preoperative implantation of veno-arterial extracorporeal membrane oxygenation lead to embolic events in infective endocarditis?
Authors: Tianlong Li, Xiaoxiao Wu, Tingrui Chen, Chun Pan, Ruiming Yue, Chunlin Xiang, Tao Yu, Zhenjie Jiang, Xiaobo Huang, Xuemei Tang, Yiping Wang
Journal: Front Cardiovasc Med (2024)
Keywords: cardiogenic shock, embolism, extracorporeal membrane oxygenation, infective endocarditis, multidisciplinary team (mdt)
MeSH terms: Case Reports

Early-stage infective endocarditis (IE) can lead to severe complications, including infarctions and metastatic infections caused by inflammatory embolus shedding. Common embolism sites include the brain, spleen, kidneys, lungs, and intestines. Additionally, acute heart failure (AHF) can occur in up to 40% of cases, and its presence can impact the clinical outcomes of patients with IE. Cardiogenic shock (CGS) is often more likely to occur after AHF has taken place. If bacteria invade the blood, infectious shock can occur. Patients with IE can experience simple CGS, septic shock, or a combination of the two. Extracorporeal membrane oxygenation (ECMO) typically serves as a Bridge for Heart failure and Cardiogenic shock. Previous research indicates that there are limited reports of ECMO support for patients with IE after CGS has occurred. Because CGS may occur at any time during IE treatment, it is important to understand the timing of ECMO auxiliary support and how to carry out comprehensive treatment after support. Timely treatment can help to reduce or avoid the occurrence of serious complications and improve the prognosis of patients with IE. Our work combines a case study to review the ECMO support of IE patients after CGS through a literature review. Overall, we suggest that when patients with IE have large bacterial thrombosis and a greater risk of shedding, it is recommended to carefully evaluate the indications and contraindications for ECMO after discussion by a multidisciplinary team (MDT). Still, active surgical treatment at an early stage is recommended.
Hope amidst crisis: exploring perinatal mental health and family dynamics in out-of-home care through virtual assessments during the UK COVID-19 response
Authors: Udita Iyengar, Jessica Heller-Bhatt
Journal: Front Glob Womens Health (2024)
Keywords: covid-19, attachment, parenting, perinatal mental health, virtual dyadic assessments

Caring for a young child exposed to early trauma, along with caregiving stress and heightened by the impact of lockdowns as a result of the COVID-19 response, may compromise the development of the parent-child relationship. Understanding a foster carer's attachment history and considering relational dynamics through an attachment lens may shed light on areas they need support in, to enhance their parenting capacity for vulnerable children. The feasibility of collecting and coding observational data and attachment interviews of foster carers and their children, when conducted remotely during COVID-19, needs to be explored. This perspective piece considers the impact on infant and perinatal health in the context of COVID-19 with particular emphasis on relational dynamics and attachment assessments, using a case study of a foster carer and her child in an out-of-home-care placement. Understanding these dynamics is crucial for safeguarding the well-being of both caregivers and vulnerable children during this challenging time.
Intractable Parathyromatosis despite extensive surgical interventions: A case report with literature review
Authors: Shada Khaled Bashantoof, Mansoor Abdulmajeed Alramadhan, Modhi Hamad Alawadh, Nada Abdulaziz Bin Samaih, Rania Abdullah Alshammari, Abdulsalam Aodah
Journal: Int J Surg Case Rep (2024)
Keywords: case report, parathyromatosis, primary hyperparathyroidism, recurrence
MeSH terms: Case Reports

Introduction and importance:
Parathyromatosis is a very rare condition where persistent hyperparathyroidism occurs after surgical excision of the parathyroid gland. That is explained by many theories mainly a seeding of parathyroid gland tissue post parathyroidectomy. We report a rare case presentation of Parathyromatosis and the clinical course with the consequences of her condition.
Case presentation:
a 38 years old female presented first time in 2003 with a parathyroid cyst that underwent excision which was ruptured accidentally and seeding of content happened. As a consequence, she had multiple presentations of recurrent hyperparathyroidism with different locations in the neck region in which parathyroid tissue was found invading muscle, subcutaneous tissue, and surrounding structure, she was managed surgically eight times during 20 years combined with medical management with intermittent remission.
Discussion:
Parathyromatosis diagnosis is challenging and requires differentiating it from other gland pathology such as adenoma or carcinoma, management must include meticulous en-block resection to eliminate all parathyroid tissue, recurrence is high which may require multiple surgeries.
Conclusion:
managing such a rare condition is very challenging in diagnosis and management ranging from medical therapy to Surgery which may reach multiple attempts to control the disease, we also refer to the reason possibly due to multiple theories of getting this condition. Such a long-term disease, it needs surveillance follow-up to prevent the complication and recurrence.