OpenMed/multicare-articles huggingface dataset:
Combined Treatment of Uterine Arteriovenous Malformation Using a 16 Fr Miniresectoscope in an Office Setting Without Anesthesia: A Case Report
Authors: Giovanni Lipari, Alessandro Messina, Carolina Teston, Paolo Alessi, Alessia Mariani, Tiziana Bruno, Fernanda Florio, Sofia Vegro, Livio Leo, Bianca Masturzo
Journal: Case Rep Obstet Gynecol (2024)
Keywords: hysteroscopy, miniresectoscope, nitrous oxide, office hysteroscopy, pericervical anesthesia, uterine arteriovenous malformation
MeSH terms: Case Reports

Arteriovenous malformations (AVMs) are abnormal connections between arteries and veins that bypass the capillary system. Among AVMs, uterine ones are very rare, and it is not possible to have clear data on their incidence, as a good part of the patients remain clinically asymptomatic. Uterine AVMs consist of abnormal communications between branches of the uterine artery and the myometrial venous plexus. They can lead to significant bleeding, resulting in severe anemia and the need for transfusions. Both medical and surgical therapeutic approaches are described in the literature; as regards surgical treatments, the hysteroscopic excision of the endometrial mass represents a conservative and minimally invasive approach. However, there are no reported cases in the literature of AVMs treated using a hysteroscopic approach under local anesthesia and in an office setting. In this article, we propose the case of a young woman diagnosed with postpartum uterine AVM, treated using a 16 Fr miniresectoscope (GUBBINI system; Tontarra Medizintechnik®, Tuttlingen, Germany) in an office setting with a pain control protocol (pericervical infiltration and nitrous oxide via bucconasal mask). No complications occurred, and the woman was discharged immediately after the procedure. Finally, the patient was asked how tolerable and acceptable the procedure was compared to expectations; the woman defined the procedure as very bearable and well tolerated. The outpatient treatment, with an adequate pain control protocol, proved to be less invasive for the woman, did not require narcosis and hospital admission, but was equally therapeutic and effective compared to the treatment performed in the operating room.
Pregnant patient with Xp11.2/transcription factor E3 translocation renal cell carcinoma: a case report and literature review
Authors: Yanchen Wang, Xiaoyan Guo, Zhe Meng, Yong Cui, Yaofei Sun
Journal: Front Oncol (2024)
Keywords: mit family translocation, pregnancy, renal cell carcinoma, transcription factor e3, transcription factor eb
MeSH terms: Case Reports

MiT family translocation renal cell carcinomas (tRCCs) primarily include Xp11.2/transcription factor E3 (TFE3) gene fusion-associated renal cell carcinoma (Xp11.2 tRCC) and t(6;11)/TFEB gene fusion-associated RCC. Clinical cases of these carcinomas are rare. Fluorescence in situ hybridization can be used to identify the type, but there are no standard diagnostic and treatment methods available, and the prognosis remains controversial. Herein, we present a case of a patient with Xp11.2 tRCC at 29 weeks of gestation. The baby was successfully delivered, and radical surgery was performed for renal cancer at the same time. This is a unique and extremely rare case. We have described the case and performed a literature review to report the progress of current research on the treatment and prognosis of pregnant patients with Xp11.2/TFE3 translocation renal cell carcinoma. This study aims to contribute to improving the diagnosis and treatment of Xp11.2 tRCC in pregnant patients.
Lipofibromatosis arising in a right labiocrural fold in a 14-month-old female: a case report study with a 3-year follow-up
Authors: Zlatan Zvizdic, Emir Milisic, Nurija Bilalovic, Nermina Ibisevic, Melika Bukvic, Semir Vranic
Journal: J Surg Case Rep (2024)
Keywords: children, diagnosis, histopathology, lipofibromatosis, surgery
MeSH terms: Case Reports

Lipofibromatosis (LF) is a rare benign fibrofatty tumor of infancy and childhood with a predilection for distal extremities, poor margination, and a high local recurrence rate. We report a toddler who presented with an LF involving her right labiocrural fold. Imaging showed a soft tissue mass extending through the right labiocrural fold with possible infiltration into the underlying muscles. The mass was excised entirely, preserving adjacent structures. The histopathologic report revealed the mass to be LF. A 3-year follow-up revealed no disease recurrence. No other cases of LF in this localization have been presented in the literature. Despite its rarity, LF should be considered in diagnosing soft tissue neoplasms in children. Accurate diagnosis and proper surgical management with complete resection are essential to reduce the postoperative recurrence risk.
Case report: A case of giant breast skin warts caused by HPV infection
Authors: Chaohui Wang, Yuyang Zhao, Zhenhua Sun, Mingjun Li
Journal: Front Oncol (2024)
Keywords: buschke-lowenstein tumor, condyloma acuminatum (ca), human papillomavirus (hpv), skin tumor, squamous cell carcinoma (scc)
MeSH terms: Case Reports

GCA, also known as Buschke-Lowenstein tumor, is a rare sexually transmitted disease associated with HPV types 6 and 111. These warts are considered histologically benign, but there is a risk of localized invasion and development of malignancy. This malignant transformation occurs most often in the perianal and vulvar areas, and involvement of other sites is relatively rare2. In this case, we report a rare case of a giant wart originating from breast skin infected with HPV and progressing to cutaneous squamous cell carcinoma.
Case Report: Leathery black plaque on the temple and scalp
Authors: Kaveri Rusia, Bhushan Madke, Soham Meghe, Yash Kashikar
Journal: F1000Res (2024)
Keywords: case report, hamartoma, nevus sebaceous, scalp
MeSH terms: Scalp / pathology, Case Reports, Adolescent, Forehead / pathology, Humans, Male, Nevus, Sebaceous of Jadassohn / pathology, Skin Neoplasms / pathology

Background:
Epidermal nevus sebaceous, commonly known as the nevus sebaceous of Jadassohn, is a congenital sebaceous hamartoma. It typically manifests as a single yellowish plaque across the head and neck and is composed of sebaceous glands. It commonly occurs during infancy and grows during puberty. Usually, it follows a benign course; however, in a few cases, it can be malignant. This is the case of a 13-year-old child with verrucous plaques on the temple and scalp.
Case report:
We report the case of a 13-year-old boy with a steadily developing hyperpigmented verrucous plaque on the scalp and ipsilateral side of his face. A dermoscopic examination revealed ridges and fissures in a cerebriform pattern with yellowish-gray globules and a papillary appearance. Physical examination and laboratory tests revealed no abnormalities. Biopsies were taken from the scalp and temple area, and the findings were consistent with the diagnosis of nevus sebaceous. The patient was referred to a plastic surgeon for a staged excision.
Conclusions:
We describe a unique example of a sebaceous nevus that affected the scalp and ipsilateral side of the face. As this hamartomatous growth carries the risk of cancer development, a dermatologist must identify the condition and begin treatment before malignant transformation occurs. This example of multiple verrucous plaques is an exception.
Post-Radiotherapy Complications in Ewing Sarcoma: A Case Report and Literature Review
Authors: Zubir S Rentiya, Resheek Nerella, Ishaan Thassu, Pugazhendi Inban, Ihab Sheikh Hanafi, Parvinder Kaur
Journal: Cureus (2024)
Keywords: chemotherapy, ewing's sarcoma (es), immunohistochemistry, metastatic es, radiation therapy
MeSH terms: Case Reports

Ewing's sarcoma (ES), the second most prevalent malignant osseous tumor in children and adolescents, primarily affects the extremities' long bones and pelvic region. Characterized by its aggressive growth, ES often presents with symptoms like swelling, pain, and neurological deficits, impacting various skeletal sites. ES involving the spine, particularly the sacral region, poses a significant challenge due to its rarity, aggressive nature, and limited sensitivity to treatments. We report the case of an 18-year-old male with recurrent metastatic ES presenting with fever, cough, and a lesion in the right humerus. Despite prior treatments and complications including spinal metastasis and cord compression, the patient's condition deteriorated, resulting in an unfortunate outcome. This case highlights the complexities in managing recurrent metastatic ES, emphasizing the need for tailored multidisciplinary approaches and early detection strategies.
Durvalumab-Induced Myocarditis and Dilated Cardiomyopathy in a Patient With Non-small Cell Lung Cancer: A Diagnostic Conundrum
Authors: Ali Khreisat, Nathanial Bartosek, Tanya Amal, Bhavinkumar Dalal
Journal: Cureus (2024)
Keywords: dilated cardiomyopthy, durvalumab, immune-checkpoint inhibitors, myocarditis, non-small cell lung carcinoma (nsclc), nonischemic cardiomyopathy
MeSH terms: Case Reports

Immune checkpoint inhibitors have been a therapeutic oncological breakthrough in managing diverse malignancies. We present a 78-year-old male with stage IIIb non-small cell lung cancer (NSCLC) managed by concurrent chemotherapy with carboplatin/pemetrexed and radiotherapy followed by monthly durvalumab injections. He presented to the hospital with shortness of breath and fluid overload after eight months of starting durvalumab. Workup, including laboratory investigations, coronary angiography, and stress myocardial magnetic resonance imaging, increased our suspicion for the diagnosis of durvalumab-induced myocarditis and nonischemic dilated cardiomyopathy. He was managed with aggressive diuresis and pulse dose steroids with an improvement in his symptoms and his cardiac function. This case illustrates an under-reported clinical side effect in the era of advancement in oncological immunotherapy.
Case Report: A Chinese child with Barth syndrome caused by a novel TAFAZZIN mutation
Authors: Mingxuan Che, Fuhai Li, Yaning Jia, Qingzheng Liu, Jian Hu, Jidong Zhang, Shiguo Liu
Journal: Front Cardiovasc Med (2024)
Keywords: barth syndrome, cardiomyopathy, neutropenia, rare x-linked disease, tafazzin
MeSH terms: Case Reports

Barth syndrome (BTHS) is a rare X-linked recessive genetic disorder characterized by a broad spectrum of clinical features including cardiomyopathy, skeletal myopathy, neutropenia, growth delay, and 3-methylglutaconic aciduria. This disease is caused by loss-of-function mutations in the TAFAZZIN gene located on chromosome Xq28, resulting in cardiolipin deficiency. Most patients are diagnosed in childhood, and the mortality rate is highest in the early years. We report a case of acute, life-threatening metabolic decompensation occurring one day after birth. A novel TAFAZZIN splice site mutation was identified in the patient, marking the first reported case of such a mutation in BTHS identified in China. The report aims to expand our understanding of the spectrum of TAFAZZIN mutations in BTHS.
Case Report: One heart with two lobes: a rare infantile congenital giant left atrial appendage aneurysm
Authors: Yu-Jen Chan, Nguyen Thi Ly Ly, Nguyen Minh Hai, Sheng-Ling Jan
Journal: Front Pediatr (2023)
Keywords: cardiomegaly, congenital heart disease, dextroposition of heart, left atrial appendage aneurysm, surgical repair
MeSH terms: Case Reports

Left atrial appendage aneurysm (LAAA) is an extremely rare congenital heart abnormality, with varying degrees of symptoms, ranging from asymptomatic to arrhythmia, thromboembolic event or airway obstruction. Most infantile cases were incidentally found by echocardiography. Contrast-enhanced chest tomography can confirm the diagnosis and inform surgical plan. We describe an asymptomatic young female infant who had a unique extreme cardiomegaly on a chest x-ray and received surgical aneurysmectomy. Her heart was restored to a normal cardiac size after the heart surgery.
Case report: Pheochromocytoma complicated by type B aortic dissection
Authors: Dan Yi, Xiatian Liu, Libin Fan
Journal: Front Cardiovasc Med (2023)
Keywords: aortic dissection, case report, computed tomography, pheochromocytoma, type b
MeSH terms: Case Reports

Introduction:
Pheochromocytomas combined with aortic dissections are rare. Treatment of aortic dissection can be complicated by the presence of pheochromocytomas.
Case presentation:
we present the case of a 48-year-old male who visited the hospital with chest and back pain for 13 h. Enhanced computed tomography (CT) revealed a type B aortic dissection combined with a left adrenal mass (72 mm). Elevated 24-h urinary vanillylmandelic acid levels can aid in the diagnosis of pheochromocytomas. Aortic dissection due to unstable hypertension secondary to pheochromocytoma is rare and complicates the procedure. Thoracic endovascular aortic repair was performed, and antihypertensive treatments were administered after surgery. After hypertension was addressed and the patient was stable, laparoscopic resection of the adrenal mass was performed.
Conclusions:
despite its rarity, it is important to consider pheochromocytoma as a differential factor for unstable hypertension when an aortic dissection is found.
Mycobacterium interjectum causing submandibular lymphadenitis in a child
Authors: Sallie Lin, Connie Trieu
Journal: Access Microbiol (2024)
Keywords: mycobacterium interjectum, nontuberculous mycobacteria, antibiotic, susceptibilities
MeSH terms: Case Reports

Nontuberculous mycobacteria (NTM) commonly manifest as cervical lymphadenitis in immunocompetent children. Only a few species, such as Mycobacterium avium complex (MAC), cause infection in children. With recent advances in gene sequencing, Mycobacterium interjectum has been identified as a rare cause of adenitis in children, with at least ten cases reported since 1993. Curative treatment for NTM lymphadenitis, particularly when caused by MAC, usually involves complete surgical excision of the affected lymph nodes. This case report highlights successful treatment of submandibular lymphadenitis caused by M. interjectum in a paediatric patient, despite multi-drug resistance in vitro.
Rhabdomyolysis and Resultant Acute Renal Failure due to Legionella Pneumonia in a Patient with Human Immunodeficiency Virus
Authors: Margaret Kypreos, Roma Mehta
Journal: Case Rep Nephrol (2023)
MeSH terms: Case Reports

Legionnaires' disease is a severe pneumonia caused by Legionella that results in laboratory abnormalities including hyponatremia and elevated liver enzymes. Rarely skeletal muscle and renal abnormalities occur. This case report describes a case of Legionella pneumonia complicated by rhabdomyolysis and acute renal failure in a patient with the human immunodeficiency virus.
Tubarial salivary glands on PSMA ligands based PET imaging and post 177Lu PSMA therapy scan: reiterating its importance
Authors: Srinivas Ananth Kumar, Anjali Meena, Ashwani Sood, Rajender Kumar, Bhagwant Rai Mittal
Journal: Asia Ocean J Nucl Med Biol (2024)
Keywords: lu-177 psma-617, pet/ct, psma, tubarial salivary glands
MeSH terms: Case Reports

68Ga-PSMA PET/CT has been routinely utilized in patients with intermediate to high-risk category prostate carcinoma for staging, biochemical recurrence and before planning the PSMA radioligand therapy (RLT). 177Lu-PSMA RLT has also been approved by FDA as a novel treatment modality in metastatic carcinoma prostate patients who have failed to other lines of treatment. The non-target organs like salivary and lacrimal glands have shown to have high physiological PSMA uptake on PSMA PET/CT. Recently, strong uptake of PSMA ligand has also been noted in the dorsal wall of the nasopharynx in the region of torus tubarius on PSMA PET/CT, which has led to the identification of new pair of salivary gland structures called "tubarial salivary glands". The clinical significance of these distinct anatomical structures lies in the fact these structures might be involved in a variety of immune related, inflammatory disorders, malignancies and could be a probable organ at risk during radiotherapy in case of head and neck malignancies, causing adverse effects to the patient.
Disaster-related deaths with alcohol-related diseases after the Fukushima Daiichi nuclear power plant accident: case series
Authors: Kemmei Kitazawa, Toyoaki Sawano, Yuna Uchi, Moe Kawashima, Hiroki Yoshimura, Michio Murakami, Saori Nonaka, Hiroaki Saito, Mamoru Sakakibara, Kazuko Yagiuchi, Mako Otsuki, Akihiko Ozaki, Chika Yamamoto, Tianchen Zhao, Taiga Uchiyama, Tomoyoshi Oikawa, Shinichi Niwa, Masaharu Tsubokura
Journal: Front Public Health (2024)
Keywords: alcohol-related diseases, disaster-related deaths, evacuation, indirect-effect, radiation disaster
MeSH terms: Disasters, Fukushima Nuclear Accident, Mental Disorders, Research Support, Non-U.S. Gov't, Ethanol, Humans, Male, Nuclear Power Plants, Ethanol

Introduction:
The health of patients with mental disorders, such as alcohol-related diseases, often deteriorates after disasters. However, the causes of death among those with alcohol-related diseases during and after radiation disasters remain unclear.
Methods:
To minimize and prevent alcohol-related deaths in future radiation disasters, we analyzed and summarized six cases of alcohol-related deaths in Minamisoma City, a municipality near the Fukushima Daiichi nuclear power plant.
Results:
Patients were generally treated for alcohol-related diseases. In one case, the patient was forced to evacuate because of hospital closure, and his condition worsened as he was repeatedly admitted and discharged from the hospital. In another case, the patient's depression worsened after he returned home because of increased medication and drinking for insomnia and loss of appetite.
Discussion:
The overall findings revealed that, in many cases, evacuation caused diseases to deteriorate in the chronic phase, which eventually resulted in death sometime after the disaster. To mitigate loss of life, alcohol-related diseases must be addressed during the chronic phases of future large-scale disasters, including nuclear disasters.
A Case report: Synovial sarcoma of the mediastinum in an 18-year-old teenager
Authors: Yan Liu, Manman Cui, Xiuzhi Zhou, Duchang Zhai, Mingyu Qin, Guohua Fan, Wu Cai
Journal: Front Oncol (2024)
Keywords: chest imaging, mediastinum, mesenchymal cell, oncology, synovial sarcoma
MeSH terms: Case Reports

Synovial sarcomas (SSs) are a rare group of malignant tumors originating from pluripotential mesenchymal cells, which commonly occur as the primary tumor in the soft tissues near the articular surface, tendons, and articular synovium. Herein, we report a rare case of mediastinal SS in an 18-year-old teenager who initially presented with cough as the primary symptom. In this case, plain chest CT and contrast-enhanced CT clearly revealed the lesion presenting as a round-like and uneven density mass in the mediastinum with heterogeneous enhancement, which compressed the trachea and invaded the adjacent vessels. Based on the results of immunohistochemistry and fluorescence in situ hybridization (FISH), combined with the differential diagnosis with other types of tumors in the mediastinum on imaging, we were able to diagnose the tumor as an SS located in the mediastinum. Subsequent resection of the lesion coupled with chemotherapy and immunotherapy led to an improvement in the patient's symptoms.
Haemophagocytic lymphohistiocytosis due to Burkholderia pseudomallei in a primigravida
Authors: Shaikh Mohammed Haroon Al Waseem, Tessa Antony, Suchitra Suresh, Sowmya Gopalan
Journal: Access Microbiol (2023)
Keywords: burkholderia pseudomallei, blood culture, haemophagocytic lymphohistiocytosis
MeSH terms: Case Reports

Introduction:
Melioidosis is caused by Burkholderia pseudomallei, a Gram-negative, saprophytic bacillus, commonly found in soil or contaminated water. As infection with this bacterium produces a wide variety of clinical manifestations the organism is aptly called the 'great mimicker'. Even though it is non-fastidious and an easily cultivable organism, it can be misidentified in automated identification systems.
Case report:
A 24-year-old primigravida presented with complaints of fever and myalgia of 45 days' duration. She was diagnosed to have haemophagocytic lymphohistiocytosis (HLH) based on clinical and laboratory parameters. Blood and bone marrow culture sent to the microbiology laboratory grew non-fermenting Gram-negative bacilli which were misidentified as Burkholderia cepacia by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) technology. It was subsequently identified as B. pseudomallei by 16S rRNA gene sequencing. The patient was commenced on intensive phase therapy with intravenous ceftazidime for 2 weeks, followed by maintenance therapy with oral trimethoprim and sulfamethoxazole for 3 months. In view of HLH, she was treated with intravenous dexamethasone for 2 weeks which was later switched to oral dexamethasone for a period of 6 weeks. She responded well to the treatment, but had to undergo medical termination of her pregnancy as there was severe intrauterine growth restriction of the fetus.
Conclusion:
Prognosis of melioidosis is excellent if early diagnosis and appropriate antibiotic treatment is provided. In this era of automation, it is important to determine if the suspected pathogen is listed in the database of the automated identification system.
Teachers as caregivers of grieving children in school in the post-COVID-19 era: using the self-determination theory to conceptualize teachers' needs when supporting grieving children's mental health
Authors: Rivi Frei-Landau
Journal: Front Pediatr (2024)
Keywords: childhood grief, post-covid-19, qualitative case study research, self-determination theory, teachers as caregivers

Background:
It has been estimated in recent studies that more than 1.5 million children worldwide lost a caregiver due to the COVID-19 pandemic. Childhood bereavement is associated with heightened risks of impaired academic and social performance, mental health issues, substance use disorders, and higher mortality rates. Yet children may receive insufficient support post-loss. Although the role of school psychologists in supporting grieving students has been examined, little is known about the role of teachers in this context. Specifically, knowledge about teachers' needs when supporting bereaved children is lacking.
Objective:
The study's aim was to explore teachers' needs, drawing upon a well-established framework-self-determination theory (SDT)-which focuses on three human needs considered essential for optimal functioning: autonomy, competence, and relatedness.
Methods:
Employing a qualitative approach, 36 teachers were interviewed about their needs when supporting grieving students. Interviews were transcribed and then analyzed using thematic content analysis.
Results:
Analysis revealed three SDT-related needs: knowledge (theory- and practice-related), acknowledgment, and support (emotional and practical).
Conclusions:
The findings enhance our theoretical understanding of childhood bereavement and may promote policy changes that ensure teachers' needs satisfaction. Its significance lies in the basic premise that supporting teachers' needs in the context of pediatric grief may eventually lead to their optimal ability to enact best practices for supporting grieving students' well-being.