OpenMed/multicare-articles huggingface dataset:
Effects of tailored interventions for anxiety management in choking-susceptible performing artists: a mixed-methods collective case study
Authors: Veronika J Lubert, Sanna M Nordin-Bates, Peter Gröpel
Journal: Front Psychol (2023)
Keywords: choking, mixed-methods, performance anxiety, performance under pressure, performing arts, psychological interventions, tailored interventions

Introduction:
Not being able to manage performance anxiety and subsequently experiencing a decline in performance have been called "choking under pressure". High trait anxiety and fear of negative evaluation, as well as low self-efficacy or self-confidence, can put performers especially at risk of experiencing choking. This study, therefore, examined the effects of psychological choking interventions tailored to "choking-susceptible" performing artists individually in a coaching setting.
Methods:
We conducted a mixed-methods (QUANT + QUAL) collective case study with nine performing artists, who each received five individual coaching sessions. The tailored choking interventions comprised acclimatization training, goal setting, and pre-performance routines, including elements such as imagery, self-talk, and relaxation techniques. Before and after the 10-week intervention phase, they filled in questionnaires on trait performance anxiety, fear of negative evaluation, and self-efficacy, performed in front of a jury, and were interviewed about their experiences. Transcripts of interviews and coaching sessions were analyzed using thematic analysis. Heart rate measurements, weekly performance videos, and expert evaluations were also part of our comprehensive data.
Results:
Quantitative data showed reductions in performance anxiety and fear of negative evaluation, and increases in self-efficacy and performance quality, from before to after the intervention phase. Most participants also had a lower heart rate when performing for the jury. Themes from qualitative analysis comprised managing nervousness and feeling more relaxed, becoming more self-confident, satisfaction with artistic and mental performance, feeling good and enjoying performing, and general positive effects.
Conclusion:
Tailoring psychological interventions may provide several benefits for choking-susceptible performing artists.
Floating-Harbor Syndrome Treated With Recombinant Human Growth Hormone: A Case Report and Literature Review
Authors: Hui Bo, Lihong Jiang, Jiaqi Zheng, Jie Sun
Journal: Front Pediatr (2021)
Keywords: floating-harbor syndrome, srcap gene, recombinant human growth hormone, short stature, treatment

Introduction: We aimed to summarize the clinical characteristics of Floating-Harbor syndrome (FHS) and the effect of recombinant human growth hormone (rhGH) to increase height. Methods: The clinical manifestations, gene sequencing results, treatment, and regression of one child with FHS were reported at the Department of Pediatrics, General Hospital of Tianjin Medical University, in July 2020. PubMed was searched using the keyword "Floating-Harbor Syndrome" up to March 2021 to obtain clinical information on children with FHS for review. Results: The child, who was a male aged 6 years and 9 months, presented to the clinic with main complaints of delayed language development since childhood and a short stature for 4 years. The child's short stature, peculiar facial features, delayed language development, and delayed bone development were considered alongside genetic testing and Sanger sequencing to verify the results. A heterozygous mutation (c.7401delC; p.Ile2468Phefs*7) was identified in exon 34 of the SRCAP gene, which was a frameshift mutation, and Sanger verification showed that neither parent had this mutation. The child was administered subcutaneous injection of rhGH (0.13 U/kg/day) and was followed up regularly. At the time of writing, the child had been treated for 6 months and was 7 years and 3 months old with a height of 106.3 cm (-3.69 SDS), which was a height increase of 6.3 cm. The patient did not complain of discomfort during treatment and presented normal laboratory tests results. Twenty-two children with FHS treated with rhGH were included in the literature review, and most of these patients demonstrated an increase in height SDS without adverse effects. Conclusion: Short stature, delayed skeletal maturation, impaired language expression, intellectual deficits, and peculiar facial features are the main clinical features of FHS. rhGH can be used as a treatment to increase height in patients with FHS, but its effectiveness and safety still need to be monitored in larger sample sizes over longer periods of time.
Isolated Fallopian Tube Torsion: A Rare Entity
Authors: Indranil Banerjee, Yatin Thakur, Gargi Mukherjee, Jitendra Jadhav, Amita Sahare
Journal: Case Rep Obstet Gynecol (2021)
MeSH terms: Case Reports

Isolated fallopian tube torsion is an extremely rare occurrence in a young female. The lady concerned presented with acute abdominal pain and the ovaries were normal on the scan with dilated fallopian tubes. On laparoscopy, it was revealed that she was suffering from fallopian tube torsion and laparoscopic salpingectomy was performed. The patient recovered well postoperatively.
A Novel c.91dupG JAG1 Gene Mutation Is Associated with Early Onset and Severe Alagille Syndrome
Authors: Alejandra Del Pilar Reyes-de la Rosa, Gustavo Varela-Fascinetto, Constanza García-Delgado, Edgar Ricardo Vázquez-Martínez, Pedro Valencia-Mayoral, Marco Cerbón, Verónica Fabiola Morán-Barroso
Journal: Case Rep Genet (2018)
MeSH terms: Case Reports

Alagille syndrome (MIM 118450) is an autosomal dominant disorder characterized by paucity of intrahepatic bile ducts, chronic cholestasis, pulmonary stenosis, butterfly-like vertebrae, posterior embryotoxon, and dysmorphic facial features. Most cases are caused by JAG1 gene mutations. We report the case of a 2-year-old Mexican mestizo patient with Alagille syndrome, having exhibited jaundice and cholestatic syndrome as of three weeks of age. Sequencing analysis of the JAG1 gene revealed the novel heterozygous mutation c.91dupG that originates a truncated protein and therefore a possibly diminished activation of the Notch signaling pathway. The latter may explain the severe phenotype of the patient. Since the mutation was not identified in the parents, it was considered a de novo event, highlighting the importance of molecular diagnosis and genetic counseling. In conclusion, this report widens the spectrum of JAG1 gene mutations associated with Alagille syndrome.
Case Report: Next-Generation Sequencing-Based Detection in A Patient with Three Synchronous Primary Tumors
Authors: Tianqi Wu, Jian Wan, Kai Xia, Muqing Yang, Lijin Feng, Lu Yin, Chunqiu Chen
Journal: Front Oncol (2022)
Keywords: bc, brca2, gist, mpt, ngs
MeSH terms: Case Reports

Clinically rare, multiple primary tumors are a growth or development of two or more neoplasms in the same individual. A 57-year-old woman with two primary cancers, namely, breast and gastric cancers, and a gastrointestinal stromal tumor was admitted. Next-generation sequencing (NGS) of the three tumors and blood was performed to determine their clonal origin and identify genetic cancer susceptibility. NGS identified that germline genetic variants potentially correlated with an individual risk of developing multiple cancers and that additional mutations are required to drive the formation of different tumors.
Endodontic Surgery of the Palatal Root of a Maxillary Molar Associated with Simultaneous Management of a Maxillary Sinus Lesion
Authors: Silvio Taschieri, Stefano Corbella, Luca Francetti, Alice Alberti, Benedetta Morandi
Journal: Case Rep Dent (2023)
MeSH terms: Case Reports

This case report describes a particular application of endodontic microsurgery with a palatal approach in the presence of a radiopaque lesion inside the maxillary sinus. The patient presented complaining of pain related to the first maxillary molar and events of nasal obstruction and facial pain in the cheek and nasal area. The endodontic orthograde treatment and retreatment were done, respectively, 7 and 4 years earlier. The cone-beam computed tomography (CBCT) scan taken before the treatment showed two separate lesions: one associated with the palatine root of the molar and another one inside the maxillary sinus. The patient agreed to solve both problems in one surgical step: endodontic surgery of the palatine root with palatal access with the simultaneous asportation of a lesion from the maxillary sinus floor. Complete bone healing of the periapical area and the maxillary sinus was visualized on intra-oral radiographs, and CBCT was taken one year after the treatment. As far as the authors know, no one in literature has ever described this approach and solved in such a conservative way both the problems at the tooth and in the maxillary sinus.
Self-arranged exposure for overcoming blood-injection-injury Phobia: a case study
Authors: Michelle R Pitkin, John M Malouff
Journal: Health Psychol Behav Med (2014)
Keywords: blood, injection, injury, phobia, self-exposure, treatment

Blood-injection-injury (BII) phobia is both common and dangerous, because it can lead to avoidance of medical procedures for diagnosis and treatment. It also tends to prevent individuals from donating blood for use in the healthcare of others. BII phobia often has an unusual characteristic for a type of phobia - fainting. The typical treatment for BII phobia involves teaching the client how to avoid fainting and staging multiple gradual-exposure trials for the client. In this case report, an adult with the phobia obtained initial, mostly written, guidance from a psychologist, arranged her own applied muscle-tension practice sessions to learn how to keep from fainting, created her own fear hierarchy, and staged exposure trials herself, ending years of avoidance of blood withdrawal. By the end of the trials, she was able to give blood for a medical test and to donate blood for the first time in her life and to work as a volunteer at a blood-donation center. The results provide the first evidence that adults with BII phobia can end the phobia by arranging their own sessions of applied-tension practice and gradual self-exposure. The results suggest a new option for treating specific phobias in general with some adults: initial professional guidance followed by self-arranged gradual-exposure trials.
Mediastinal Extension of a Pancreatic Pseudocyst: A Rare Intrathoracic Complication of Pancreatitis
Authors: Carol Vitellas, Ivo Besong Mangeb, Luis Regalado, Chiemezie Chianotu Amadi
Journal: Case Rep Radiol (2021)
MeSH terms: Case Reports

Pancreatic pseudocysts are a common complication of pancreatitis. However, mediastinal extension of a pseudocyst is rare and often presents with atypical symptoms. We present a case of mediastinal extension of a pancreatic pseudocyst in a 56-year-old woman with a history of alcohol-related chronic pancreatitis, who presented with acute on chronic epigastric abdominal pain and atypical chest pain. Serum lipase was elevated, and imaging by contrast-enhanced computed tomography (CT) demonstrated a paraesophageal fluid collection. This collection was continuous with a peripancreatic pseudocyst and extended into the posterior mediastinum via the esophageal hiatus. Mediastinal extension of a pancreatic pseudocyst was confirmed by magnetic resonance imaging (MRI). The patient was managed conservatively in the hospital with parenteral nutrition therapy, pain control, and close imaging observation. The patient was discharged home to continue conservative management and close imaging follow-up. An initial follow-up CT examination 8 weeks after discharge revealed interval decrease in the posterior mediastinal collection but also interval development of loculated left pleural and pericardial effusions.
A Case of Acute Myocardial Infarction in a Patient Whose Initial Complaints Were Hematemesis and Epigastric Discomfort
Authors: Kazuhiko Omori, Youichi Yanagawa
Journal: Case Rep Emerg Med (2019)
MeSH terms: Case Reports

The patient was a 64-year-old woman with systemic lupus erythematosus, thrombophlebitis of the lower legs, cerebral infarction with left hemiparesis, and colostomy after perforation of the sigmoid colon. On the morning of her presentation, the patient felt epigastric abnormality. Thereafter, hematemesis occurred twice, leading her to call an ambulance in the afternoon. Upon arrival, electrocardiography before securing a venous route and obtaining blood samples revealed ST segment elevation in leads II, III, and aVF. As her vital signs were stable and her hemoglobin level had decreased by just 1.1 g/dl in comparison to the previous day, emergency coronary angiography (CAG) was performed. CAG revealed complete occlusion at section #4. She underwent right coronary angioplasty with stent placement. The patient's course after angioplasty was uneventful. On the 15th hospital day, esophagogastroduodenoscopy revealed esophageal erosion and superficial gastritis. She was discharged on foot the following day. When physicians treat patients with hematemesis, electrocardiography and the measurement of troponin are essential before esophagogastroduodenoscopy.
Pulmonary thromboembolism in conjunction with intracavitary thrombus caused by severe acute respiratory syndrome coronavirus-2 infection in a patient living with human immunodeficiency virus
Authors: Ana Carolina Veronese Silva, Paulo André Bispo Machado-Junior, Leticia Bressan Anizelli, Rebecca Benicio Stocco, Lidia Ana Zytynski Moura, Jarbas da Silva Motta Junior, Gustavo Gavazzoni Blume
Journal: Rev Soc Bras Med Trop (2021)
MeSH terms: COVID-19, HIV Infections / complications, Pulmonary Embolism / etiology, Thrombosis, Case Reports, Adult, HIV, Humans, Male, SARS-CoV-2

Approximately one-third of patients with coronavirus disease 2019 (COVID-19) present with coagulation disorders and hematological changes. However, the clinical manifestations of COVID-19 and prognoses of people living with human immunodeficiency virus (HIV) remain controversial. This study reports the case of a 27-year-old HIV-infected man who regularly used antiretroviral medications, had no other comorbidities and was admitted for acute respiratory distress syndrome caused by COVID-19. Complementary examinations during hospitalization revealed a diagnosis of pulmonary thromboembolism in association with an intracavitary thrombus.
Successful Selective Embolization for Recurrent Hemarthrosis after Knee Arthroplasty
Authors: Cristian Barrientos, Maximiliano Barahona, Tomas Cermenati, Rodrigo Wulf, Jaime Hinzpeter
Journal: Case Rep Orthop (2019)
MeSH terms: Case Reports

Knee replacement has demonstrated to be a cost-effective treatment for severe knee osteoarthritis. Nevertheless, perioperative complications may occur, including recurrent hemarthrosis reaching an incidence between 0.3 and 1.6%. Success rate after conservative treatment has been reported to be above 80%, but in case of recurrence, computed tomography angiography, magnetic resonance angiography, and Doppler ultrasound have been used to conduct the diagnosis. Arthroscopy or selective embolization is used for treatment depending on the etiology of the bleeding. Open surgery is performed in the rare cases of failure of the above alternatives. The patient consulted seven months after total knee arthroplasty with sudden pain in the medial side of the knee. Infection was ruled out, and arthrocentesis shows hemarthrosis. Successful selective embolization of medial superior and lateral superior genicular artery was performed. After two years, the patients report 92 points in the Forgotten joint score, 0 in Womac pain, 1 in Womac stiffness, and 3 in Womac functional score.
Alveolar Hemorrhage, a Rare and Life-Threatening Complication of Catastrophic Antiphospholipid Syndrome
Authors: Grace Loza, Carlos Hallo, Byron Chiliquinga, Alejandro Hallo
Journal: Case Rep Rheumatol (2019)
MeSH terms: Case Reports

Alveolar hemorrhage is the rarest pulmonary complication of catastrophic antiphospholipid syndrome and is associated with high mortality risk. This life-threatening complication results from autoimmune damage to the alveolar blood vessels. Given the limited literature addressing the association of these two pathologies, we report a series of three cases with this complication and then compare our findings with 6 cases reported in the literature.
Chronic Active Epstein-Barr Virus Infection With Systemic Vasculitis and Pulmonary Arterial Hypertension in a Child
Authors: Hongjun Ba, Lingling Xu, Huimin Peng, Yuese Lin, Xuandi Li, Huishen Wang, Youzhen Qin
Journal: Front Pediatr (2019)
Keywords: cardiac insufficiency, chronic active epstein–barr virus infection, coronary artery aneurysm, pulmonary arterial hypertension, vasculitis
MeSH terms: Case Reports

Introduction: A chronic active Epstein-Barr virus (EBV) infection (CAEBV), which is characterized by persistent "infectious mononucleosis-like" symptoms, can lead to cardiovascular complications, including coronary artery aneurysms. No published studies have reported an occurrence of chronic EB virus infection in conjunction with systemic vasculitis and pulmonary hypertension. Case Presentation: Herein, we present a case of a 9-year-old boy with CAEBV, associated with pulmonary arterial hypertension (PAH) and systemic vasculitis. Recurrent skin ulcers were a major early clinical manifestation in this case. The histopathological examination of a dermal biopsy sample from the lesions revealed vasculitis, and the in-situ hybridization test was positive for EBV-encoded small RNA. Results: The patient was administered immunosuppressants (prednisolone and cyclophosphamide) and targeted drugs (sildenafil and bosentan) to control the pulmonary pressure. This combination therapy decreased the systolic pulmonary arterial pressure to 40 mm Hg (on echocardiography), and the N-terminal pro b-type natriuretic peptide level also reduced to 62.3 pg/ml. After discontinuation of prednisone, the child developed shortness of breath, edema, and oliguria. He was again started on prednisone, with an addition of thalidomide. Sildenafil was replaced by riociguat, due to the side effect of penile erection. The patient is being followed up every 2 months at the clinic. The most recent follow-up visit was 2 weeks before this report was written, during which, the child was observed to have no rash, shortness of breath, edema, and other symptoms. Written informed consent was obtained from the parents for the publication of this case report. Conclusion: A CAEBV should be considered among the differential diagnoses while managing a pediatric patient with secondary PAH and systemic vasculitis. However, elucidation of its potential pathophysiological mechanisms requires further study.
Cytohistological correlation of early changes in spontaneously infarcted fibroadenoma-a rare case report
Authors: Ht Kamra, Pa Gadgil, Sa Chaware, Ab Kolhe, Pw Sakinlawar
Journal: Ecancermedicalscience (2012)
MeSH terms: Case Reports

Fibroadenoma is the most commonly diagnosed benign tumour in adolescents and young women but spontaneous infarction in fibroadenoma is rarely seen. We report here a case of spontaneously infracted fibroadenoma in a 20 year old unmarried female without history of trauma or previous fine needle aspiration. It is important to recognize this entity because microscopic findings in an infarct are influenced by the duration of the infarct and on cytology it mimics mastitis, duct ectasia and even carcinoma.
Case Report: Signal Transducer and Activator of Transcription 3 Gain-of-Function and Spectrin Deficiency: A Life-Threatening Case of Severe Hemolytic Anemia
Authors: Sara Ciullini Mannurita, Rayan Goda, Ebe Schiavo, Maria Luisa Coniglio, Annachiara Azzali, Ilaria Fotzi, Annalisa Tondo, Veronica Tintori, Stefano Frenos, Maria Chiara Sanvito, Marina Vignoli, Cristina Luceri, Elisabetta Bigagli, Alessia Grassi, Mario Milco D'Elios, Claudio Favre, Eleonora Gambineri
Journal: Front Immunol (2021)
Keywords: stat3 gain-of-function, autoimmune lymphoproliferative syndrome, hematopoietic stem cell transplantation, hemolytic anemia, hereditary spherocytosis, lymphadenopathy, primary immune regulatory disorders, spectrin deficiency
MeSH terms: Agammaglobulinemia / genetics, Anemia, Hemolytic, Autoimmune / genetics, Gain of Function Mutation, Lymphoproliferative Disorders / genetics, STAT3 Transcription Factor / genetics, Spectrin / deficiency, Case Reports, Research Support, Non-U.S. Gov't, Agammaglobulinemia / immunology, Age of Onset, Anemia, Hemolytic, Autoimmune / immunology, Child, Cyclosporine / adverse effects, Cyclosporine / pharmacokinetics, Cyclosporine / therapeutic use, Cytochrome P-450 CYP3A / genetics, Female, Germ-Line Mutation, Graft vs Host Disease / drug therapy, Graft vs Host Disease / etiology, Growth Disorders / genetics, Hematopoietic Stem Cell Transplantation, Humans, Immunoglobulins, Intravenous / therapeutic use, Immunosuppressive Agents / therapeutic use, Lymphoproliferative Disorders / drug therapy, Lymphoproliferative Disorders / immunology, Mutation, Missense, Polymorphism, Single Nucleotide, Prednisolone / therapeutic use, Retinal Hemorrhage / chemically induced, STAT3 Transcription Factor / physiology, Spectrin / genetics, Unrelated Donors, Immunoglobulins, Intravenous, Immunosuppressive Agents, STAT3 Transcription Factor, STAT3 protein, human, Spectrin, Cyclosporine, Prednisolone, Cytochrome P-450 CYP3A, CYP3A4 protein, human

STAT3 gain-of-function (GOF) mutations can be responsible for an incomplete phenotype mainly characterized by hematological autoimmunity, even in the absence of other organ autoimmunity, growth impairment, or severe infections. We hereby report a case with an incomplete form of STAT3 GOF intensified by a concomitant hereditary hematological disease, which misleads the diagnosis. The patient presented with lymphadenopathy, splenomegaly, hypogammaglobulinemia, and severe autoimmune hemolytic anemia (AIHA) with critical complications, including stroke. A Primary Immune Regulatory Disorders (PIRD) was suspected, and molecular analysis revealed a de novo STAT3 gain-of-function mutation. The response to multiple immune suppressive treatments was ineffective, and further investigations revealed a spectrin deficiency. Ultimately, hematopoietic stem cell transplantation from a matched unrelated donor was able to cure the patient. Our case shows an atypical presentation of STAT3 GOF associated with hereditary spherocytosis, and how achievement of a good long-term outcome depends on a strict clinical and laboratory monitoring, as well as on prompt therapeutic intervention.