OpenMed/multicare-articles huggingface dataset:
Integrated Development Environment for EEG-Driven Cognitive-Neuropsychological Research
Authors: Shoham Jacobsen, Oded Meiron, David Yoel Salomon, Nir Kraizler, Hagai Factor, Efraim Jaul, Elishai Ezra Tsur
Journal: IEEE J Transl Eng Health Med (2020)
Keywords: emotiv, python, working memory in elderly

Background: EEG-driven research is paramount in cognitive-neuropsychological studies, as it provides a non-invasive window to the underlying neural mechanisms of cognition and behavior. A myriad collection of software and hardware frameworks has been developed to alleviate some of the technical barriers involved in EEG-driven research. Methods: we propose an integrated development environment which encompasses the entire technical "data-collection pipeline" of cognitive-neuropsychological research, including experiment design, data acquisition, data exploration and analysis in a state-of-the-art user interface. Our framework is based on a unique integration between a python-based web framework, time-oriented databases and object-based data schemes. Results: we demonstrated our framework with the recording and analysis of an n-Back task completed by 15 elderly (ages 50 to 80) participants. This case study demonstrates the highly utilized nature of our integrated framework with a challenging target population. Furthermore, our results may provide new insights into the correlation between brain activity and working memory performance in elderly people, who are prone to experience accelerated decline in executive prefrontal cortex functioning. Conclusion: our framework extends the range of EEG-driven experimental methods for assessing cognition available for cognitive-neuroscientists, allowing them to concentrate on the creative part of their work instead of technical aspects.
Case Report: Late-Onset Lennox-Gastaut Syndrome Treated With Stereotactic Electroencephalography-Guided Radiofrequency Thermocoagulation Before Craniotomy
Authors: Sixian Li, Xiaodong Cai, Chen Yao, Yuanqing Wang, Xiaohua Xiao, Huafeng Yang, Yi Yao, Lei Chen
Journal: Front Neurol (2022)
Keywords: case report, late-onset lennox-gastaut syndrome, radiofrequency thermocoagulation, refractory epilepsy, stereotactic electroencephalography
MeSH terms: Case Reports

The onset of Lennox-Gastaut syndrome (LGS), a severe epilepsy syndrome, is typically before 8 years of age. Late-onset LGS (with onset in adolescence and adulthood) is relatively rare clinically and has some differences from classical LGS. Herein, we describe the case of a patient with late-onset LGS and provide a literature review of such cases. The patient had focal epilepsy onset at 8 years of age. After a 9-year evolution, he suffered seizures of different types and had a diagnosis of late-onset LGS. Drug treatment was ineffective. Nothing was found on stereotactic electroencephalography (SEEG) and magnetic resonance imaging (MRI) during the course of the disease. After the second presurgical evaluation, we found a suspicious focus on high-resolution structural MRI which was verified by SEEG at last. After SEEG-guided radiofrequency thermocoagulation (RFTC), his seizures were controlled, and his cognitive function and quality of living clearly improved. However, his seizures recurred 2 years later, and he underwent left occipital resection. Thereafter, his seizures have been controlled until now. This case emphasizes the importance of high-resolution structural MRI in the treatment of LGS. Furthermore, it suggests that late-onset LGS may be caused by focal lesions and evolve from focal epilepsy. Thus, characterizing the clinical symptoms and performing individualized electroencephalographic follow-up are both very important. Additionally, the clinical outcome in this case implies the value and limitations of RFTC in patients with epilepsy and a clear focal lesion. Moreover, this case further supports differences between late-onset and classical LGS in terms of clinical manifestation, cognitive changes, prognosis, and treatment.
Transperitoneal Robot-Assisted Radical Prostatectomy Should Be Considered in Prostate Cancer Patients with Pelvic Kidneys
Authors: Sophie Plagakis, Darren Foreman, Peter Sutherland, Andrew Fuller
Journal: J Endourol Case Rep (2016)
MeSH terms: Case Reports

We highlight two cases of transperitoneal robot-assisted radical prostatectomy (RARP) in patients with pelvic kidneys because of congenital development and renal transplant. These uncommon cases present a challenge to the surgeon contemplating surgery because of access and anomalous vascular and ureteral anatomy. We describe the technical considerations that are paramount in effectively completing transperitoneal RARP, and believe it should be considered as a treatment option in men with pelvic kidneys.
Suspected Brugada Phenocopy Secondary to Coronary Slow Flow
Authors: Alicia Shim, Rajeev Seecheran, Valmiki Seecheran, Sangeeta Persad, Shiva Sreenivasan, Ronald Henry, Naveen Anand Seecheran
Journal: Case Rep Cardiol (2019)
MeSH terms: Case Reports

Brugada syndrome (BrS) is a genetic condition that accentuates the risk of potentially lethal ventricular arrhythmias and sudden cardiac death (SCD) in a structurally normal heart. The Brugada electrocardiographic pattern may manifest separately from the syndrome-this clinical scenario has been described as Brugada phenocopy (BrP). Many etiologies of BrP have been reported, but it has not yet been reported as a result of coronary slow flow (CSF) phenomenon. This case report highlights a suspected coronary slow flow-associated Brugada type 1 electrocardiographic pattern, which subsequently normalized following the institution of guideline-directed medical therapy for acute coronary syndrome.
Pulmonary sequestration presented as massive left hemothorax and associated with primary lung sarcoma
Authors: Vincenzo Di Crescenzo, Paolo Laperuta, Filomena Napolitano, Chiara Carlomagno, Alfredo Garzi, Mario Vitale
Journal: BMC Surg (2013)
MeSH terms: Bronchopulmonary Sequestration / complications, Fibrosarcoma / complications, Hemothorax / etiology, Lung Neoplasms / complications, Case Reports, Adult, Bronchopulmonary Sequestration / diagnosis, Female, Humans

Pulmonary sequestration is an uncommon disease, accounting for only approximately 1.5% of all congenital pulmonary malformations. In most cases, the diagnosis is a result of accidental radiological findings; it is rarely accompanied by clinical symptoms, and is more commonly associated with other congenital malformations. Herein, we reported a case of pulmonary sequestration presented as massive left hemothorax and associated with primary lung sarcoma. A pneumonectomy via thoracotomy was attended with complete resection of sequestration and of sarcoma. The postoperative course was unremarkable, and the patient was discharged on postoperative day 11.
Neural Plasticity in a French Horn Player with Bilateral Amelia
Authors: Daniel S Scholz, Marcus Heldmann, Bahram Mohammadi, Thomas F Münte, Eckart Altenmüller
Journal: Neural Plast (2021)
MeSH terms: Brain / physiopathology, Ectromelia / physiopathology, Motor Skills / physiology, Neuronal Plasticity / physiology, Case Reports, Adolescent, Brain / diagnostic imaging, Brain Mapping, Ectromelia / diagnostic imaging, Humans, Male, Movement / physiology

Precise control of movement and timing play a key role in musical performance. This motor skill requires coordination across multiple joints, muscles, and limbs, which is acquired through extensive musical training from childhood on. Thus, making music can be a strong driver for neuroplasticity. We here present the rare case of a professional french horn player with a congenital bilateral amelia of the upper limbs. We were able to show a unique cerebral and cerebellar somatotopic representation of his toe and feet, that do not follow the characteristic patterns of contralateral cortical and ipsilateral cerebellar layout. Although being a professional horn player who trained his embouchure muscles, including tongue, pharyngeal, and facial muscle usage excessively, there were no obvious signs for an expanded somatosensory representation in this part of the classic homunculus. Compared to the literature and in contrast to control subjects, the musicians' foot movement-related activations occurred in cerebellar areas that are typically more related to hand than to foot activation.
Tooth Reattachment and Palatal Veneer on a Multidisciplinary Approach of Crown Fractures in Upper Central Incisors
Authors: Vanessa Machado, Ricardo Alves, Luísa Lopes, João Botelho, José João Mendes
Journal: Case Rep Dent (2017)
MeSH terms: Case Reports

Dental trauma is more common in young patients and its sequelae may have great impact on the esthetics, functions, and phonetics. This paper reports a case of trauma in both central incisors in a young 17-year-old patient who was treated using adhesive tooth fragment reattachment on tooth 2.1 and a palatal indirect composite veneer on tooth 1.1. Regarding the available literature and fracture extension, the treatment approach proposed for this case provided good functional and esthetic outcomes. Clinical and radiographic results after 1 year were successful. This case demonstrates the importance of establishing a multidisciplinary approach for successful dental trauma management.
A delayed-onset rectourethral fistula after intersphincteric resection for very low rectal cancer: a case report and literature review
Authors: Koji Komori, Kenya Kimura, Takashi Kinoshita, Seiji Ito, Tetsuya Abe, Yoshiki Senda, Kazunari Misawa, Yuichi Ito, Norihisa Uemura, Seiji Natsume, Jiro Kawakami, Yoshinori Iwata, Masayuki Tsutsuyama, Itaru Shigeyoshi, Tomoyuki Akazawa, Daisuke Hayashi, Yasuhiro Shimizu
Journal: Surg Case Rep (2015)
Keywords: intersphincteric resection, rectal cancer, rectourethral fistula

Rectourethral fistula is one of the complications that can occur after prostatectomy in the urologic discipline. However, a delayed-onset rectourethral fistula after intersphincteric resection (ISR) for low rectal cancer is extremely rare. Here, we report one such case in a 57-year-old man. After ISR for low rectal cancer with a diverting stoma (DS), the DS was closed. After approximately 1 year, frequent pneumaturia and right orchitis were observed. Results of contrast enemas and abdominal computed tomography examinations revealed a rectourethral fistula from an anastomosis to the urethra. The colonoscopic appearance revealed a pinhole fistula on the anastomotic line, with thick pus. We performed a transverse colostomy, and the pneumaturia and right orchitis were no longer observed. Two months later, colonoscopy, contrast enemas, and cystoscopy revealed no rectourethral fistula. To the best of our knowledge, our case is the first report of a delayed-onset rectourethral fistula after ISR.
Treatment of sexual trauma dissolves contamination fear: case report
Authors: Mirjam J Nijdam, Marthe M van der Pol, Ron E Dekens, Miranda Olff, Damiaan Denys
Journal: Eur J Psychotraumatol (2013)
Keywords: eye movement desensitization and reprocessing, obsessive–compulsive disorder, combined treatment, comorbidity, pharmacological treatment, posttraumatic stress disorder, psychotherapy
MeSH terms: Case Reports

Background:
In patients with co-morbid obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD), repetitive behavior patterns, rituals, and compulsions may ward off anxiety and often function as a coping strategy to control reminders of traumatic events. Therefore, addressing the traumatic event may be crucial for successful treatment of these symptoms.
Objective:
In this case report, we describe a patient with comorbid OCD and PTSD who underwent pharmacotherapy and psychotherapy.
Methods:
Case Report. A 49-year-old Dutch man was treated for severe PTSD and moderately severe OCD resulting from anal rape in his youth by an unknown adult man.
Results:
The patient was treated with paroxetine (60 mg), followed by nine psychotherapy sessions in which eye movement desensitization and reprocessing (EMDR) and exposure and response prevention (ERP) techniques were applied. During psychotherapy, remission of the PTSD symptoms preceded remission of the OCD symptoms.
Conclusions:
This study supports the idea of a functional connection between PTSD and OCD. Successfully processing the trauma results in diminished anxiety associated with trauma reminders and subsequently decreases the need for obsessive-compulsive symptoms.
Case Report: Infection With SARS-CoV-2 in the Presence of High Levels of Vaccine-Induced Neutralizing Antibody Responses
Authors: Bianca Schulte, Benjamin Marx, Marek Korencak, Dorian Emmert, Souhaib Aldabbagh, Anna Maria Eis-Hübinger, Hendrik Streeck
Journal: Front Med (Lausanne) (2021)
Keywords: sars-cov-2, breakthrough infection, mrna vaccines, neutralizing antibodies, virus variants
MeSH terms: Case Reports

We present a case of SARS-CoV-2 B.1. 525 infection in a healthcare worker despite the presence of highly neutralizing, multivariant-specific antibodies 7 weeks after full vaccination with the mRNA vaccine BNT162b2. We show that the virus replicated to high levels in the upper respiratory tract over the course of several days in the presence of strong antibody responses. The virus was readily propagatable in vitro, demonstrating the potential to transmit to others, bolstered by the fact that several household members were equally infected. This highlights the importance of protective measures even in vaccinated individuals.
Case report: Diagnosis and treatment of delayed epidural pyogenic abscess after brain tumor operation: a report of 5 cases and review of the literature
Authors: HePing Shen, YingCong Lin, ZhengMin Chu, GengHuan Wang, WenLai Chu
Journal: Front Surg (2023)
Keywords: brain tumor, epidural abscess, prognosis, surgery, treatment
MeSH terms: Case Reports

Objective:
To explore the clinical manifestations and treatment of delayed epidural pyogenic abscess after brain tumor surgery.
Method:
To retrospectively analyze the medical records of 5 patients with delayed epidural pyogenic abscess after brain tumor surgery in our hospital from January 2010 to December 2020, including clinical manifestations, laboratory results, imaging findings, treatment measures, prognosis, etc. The causes of epidural abscesses were analyzed, and the treatment methods and prognosis were evaluated.
Result:
Among the 5 cases, there were 4 male and 1 female patient, aged 52-75 years. Three cases were gliomas and 2 cases were meningiomas. Four cases received postoperative radiotherapy, and 1 case had open frontal sinus during operation. None of the surgical incisions were infected. The time between the tumor surgery and the discovery of an epidural abscess was 1.5 to 24 months. All 5 patients had headaches, 1 case had a fever, and 2 cases had limb dysfunction. Three cases had elevated blood inflammatory markers. MRI- DWI showed restricted diffusion. All 5 patients underwent surgery, 4 patients had bone flap removed, and 1 patient had bone flap retained. Bacterial culture was positive in 3 cases and negative in 2 cases. All 5 cases were cured, followed up for 1.5-9 years, and no epidural abscess recurred.
Conclusion:
The clinical manifestations and laboratory results of delayed epidural pyogenic abscess after brain tumor surgery are not specific, but MRI-DWI has specificity. Postoperative radiotherapy for brain tumors and intraoperative opening of the frontal sinus may be associated with delayed epidural pyogenic abscess. For patients with normal skin flap and no serious inflammation of the bone flap, clinicians can attempt to preserve the bone flap.
Significant Bradycardia in Critically Ill Patients Receiving Dexmedetomidine and Fentanyl
Authors: Channing Hui, Maria Cardinale, Balaji Yegneswaran
Journal: Case Rep Crit Care (2017)
MeSH terms: Case Reports

Purpose:
To report a case series of three patients who developed significant bradycardia while receiving the combination of dexmedetomidine and fentanyl for sedation and analgesia.
Materials and methods:
This is a case series of patients obtained from a mixed medical, surgical, and cardiac ICU in a community teaching hospital. Three intubated patients receiving fentanyl and dexmedetomidine infusion developed sudden bradycardia requiring intervention. In all three cases, adjustments to therapy were required.
Results:
All three patients experienced significant bradycardia, with a heart rate less than 50 bpm, and one patient briefly developed asystole. In Case 1, the fentanyl infusion rate was reduced by 67% and the dexmedetomidine infusion rate was reduced by 25%. In Case 2, the sedation was changed to midazolam, and in Case 3, both fentanyl and dexmedetomidine were discontinued. In all three cases, there were no further incidences of significant bradycardia following intervention.
Conclusions:
Fentanyl used in combination with dexmedetomidine can result in clinically significant bradycardia. Further study is warranted to identify risk factors and elucidate the mechanisms that result in life-threatening bradycardia.
A case report of puffer fish poisoning in singapore
Authors: Y S Yong, L S Quek, E K Lim, A Ngo
Journal: Case Rep Med (2013)

Although many Asians regard puffer fish as a delicacy since ancient times, puffer fish (Lageocephalus scitalleratus) is also a well-known source of possibly lethal food poisoning. The fish is gaining popularity in Singapore and can be found in quite a few restaurants now. Puffer fish contains tetrodotoxin (TTX), a potent poison affecting the neural pathway. Puffer fish poisoning may cause a constellation of symptoms, such as giddiness, numbness and tingling sensation of the mouth, paresthesia, and muscle weakness. Severe cases may present with respiratory depression, circulatory failure, and death. TTX poisonings have been reported in Japan, Taiwan, Hong Kong, Bangladesh, and the United States (Haque et al. 2008). We report a case of mild poisoning and suggest observation for such cases.
Pilonidal sinus of the perianal region: Difficult to diagnose
Authors: Ozlem Zeliha Sert
Journal: Int J Surg Case Rep (2020)
Keywords: abscess, perianal gland, phenol, pilonidal sinus
MeSH terms: Case Reports

Background:
Pilonidal sinus usually arises in the area of natal cleft in young men. Hair accumulation in the wound in the perianal region is very rare. Although pelvic magnetic resonance imaging (MRI) is used in the differential diagnosis of perianal region diseases, it is not possible to diagnose perianal pilonidal sinus by MRI.
Case:
A 24-year-old male patient presented with the complaint of swelling and itching in the anus for several months. On physical examination, the area giving endure and fluctuation was detected in the perianal region. An area of ​​2 × 2 cm hyperintense in T2 was seen in pelvic MRI. In the surgical exploration, collection of hair was seen at 7 o'clock at perianal region with pus discharge. After the cavity was cleaned, crystallized phenol was applied to the area and the wound was left to secondary healing. Granulation was observed after 4 weeks.
Conclusion:
Perianal pilonidal sinus is very rare in the literature and is often confused with other perianal diseases such as perianal abscess or anal fistula. In this respect, when examining perianal diseases, especially in young men, perianal pilonidal sinus should be kept in mind in the differential diagnosis.
Arthroscopic Management and Radiographic Interpretation of an Everted Bony Bankart Lesion
Authors: Alexander J Hron, Benjamin C Noonan
Journal: Case Rep Orthop (2018)
MeSH terms: Case Reports

Soft tissue injuries are prevalent after traumatic anterior shoulder dislocation. However, bony fractures, often referred to as bony Bankart injuries, are less common. The authors describe the case of a 16-year-old male who displayed a bony Bankart with a unique, everted presentation. The patient presented with left shoulder pain, restricted range of motion, and crepitus. Two weeks prior to physical examination, he sustained a traumatic anterior glenohumeral dislocation after a bicycle accident, which reduced spontaneously. Plain film imaging revealed a bony fragment off the anterior glenoid. Upon critical examination of magnetic resonance imaging axial cuts, the bony fragment was found to be flipped. Intraoperatively, this orientation was confirmed. The fragment was reduced and stabilized in an anatomic position using a double row technique with the capsule then advanced over the top of the fragment using three additional anchors. Imaging four months postoperatively revealed an anatomical reduction of the fragment. To the authors' knowledge, this is the first reported case of bony fragment eversion following traumatic anterior shoulder dislocation. Although the incidence of everted bony fragments following traumatic dislocation is unknown, such a situation presents unique challenges to the orthopedic surgeon. The authors discuss potential eversion mechanisms, fragment identification by imaging, surgical indications, and operative techniques.
Case Report: A Chronological Combination Treatment of Icotinib, Osimertinib, and Crizotinib on Lung Adenocarcinoma Guided by Serial Genetic Tests of Circulating Tumor DNA and Sediment Cell Genomic DNA From Pleural Effusion
Authors: Zhihua Miao, Tianhao Mu, Longying Liu, Jingjie Rao, Min Jin, Zhizheng Wang, Hui Wang, Chao Lu, Xiaolin Gong, Dongcai Zheng, Daoming Zheng, Xin Li, Yingmei Li, Shifu Chen, Xinhua Shu
Journal: Front Oncol (2020)
Keywords: egfr mutation, met amplification, ctdna and pe-sdna, lung adenocarcinoma, serial genetic monitoring
MeSH terms: Case Reports

Precision medicine has been getting more attention in lung cancer treatment. Here, we report an unusual case of a 71-year-old Chinese male patient with poorly differentiated lung adenocarcinoma with lymph node metastasis. A 5 years' treatment history of this patient is reported. By serial genetic tests of circulating tumor DNA (ctDNA) from peripheral blood and sediment cell genomic DNA (PE-sDNA) from pleural effusion, a novel chronological combination treatment of icotinib, osimertinib, and crizotinib was adopted for the present genetic mutations, including EGFR exon 19 deletion, EGFR p.T790M, and MET amplification.
Meningoencephalitis with Streptococcus equi Subspecies equi Leading to a Dural Arteriovenous Fistula
Authors: Jeroen Kerstens, Busra Durmus, Stijn Lambrecht, Ingrid Baar, Margareta M Ieven, Thijs Van Der Zijden, Paul M Parizel, Tomas Menovsky, Martin M Y Lammens, Philippe G Jorens
Journal: Case Rep Neurol Med (2021)
MeSH terms: Case Reports

Invasive infection with Lancefield group C streptococci in humans is extremely rare, with the vast majority of clinical isolates belonging to Streptococcus dysgalactiae subsp. equisimilis. We report a case of meningoencephalitis in a 69-year-old man caused by Streptococcus equi subsp. equi, a microbe that causes strangles in Equus caballus (i.e., the horse). This is only the fourth infection with this subtype of the central nervous system (CNS) reported in humans. The invasiveness of these bacteria, known to be capable of releasing strongly immunogenic exotoxins, is illustrated by white matter lesions that are present in the acute phase. This patient initially recovered well after treatment with antibiotics and glucocorticoids. However, the patient was readmitted 5 months later with multiple intraparenchymatous cerebral haemorrhages. Cerebral angiography confirmed the presence of a suspected superficial dural arteriovenous fistula (DAVF), which is seldom reported after CNS infection. The invasiveness of these bacteria was illustrated by white matter lesions present in the acute phase and the occurrence of a de novo dural arteriovenous fistula in the follow-up period.