OpenMed/multicare-articles huggingface dataset:
Kikuchi-fujimoto disease associated with myasthenia gravis: a case report
Authors: Olukayode Onasanya, David Nochlin, Victor Casas, Leema Reddy Peddareddygari, Raji P Grewal
Journal: Case Rep Med (2010)
MeSH terms: Case Reports

Kikuchi-Fujimoto disease is a self-limited benign condition of unknown etiology characterized by cervical lymphadenopathy, fever, and leucopenia. An autoimmune hypothesis has been suggested and an association with systemic lupus erythematosus, Sjogren's disease, and antiphospholipid syndrome has been noted. We report a 27-year-old male who presented for evaluation of weakness and he was diagnosed with seropositive generalized myasthenia gravis and underwent a thymectomy. He was stable until five months post-thymectomy, when he developed a high fever associated with nontender cervical lymphadenopathy, chills, and night sweats. Histopathology of a cervical lymph gland biopsy was compatible with Kikuchi-Fujimoto lymphadenitis. He improved spontaneously and was asymptomatic at the followup six months later. Our case expands the association of Kikuchi-Fujimoto disease with autoimmune disorders to include myasthenia gravis.
Recurrent Unprovoked Venous Thrombosis (Cerebral Sinus Thrombosis and Mesenteric Vein Thrombosis) in Young Patient with Crohn's Disease: A Case Report and Review
Authors: Abdullah Mohammed Albishi, Rafaat Chakik, Ali Saleh Alshamrani
Journal: Case Rep Gastrointest Med (2020)
MeSH terms: Case Reports

Inflammatory bowel disease (IBD) patients have a higher risk of thrombosis. Most data about thrombosis in inflammatory bowel disease are related mainly to inpatients with disease activity, but in this article, we report one case of inflammatory bowel disease with two different sites of venous thrombosis which happened in a patient with nonactive IBD at an outpatient setting.
A Case of Metaplastic Breast Cancer with Prolonged Response to Single Agent Liposomal Doxorubicin
Authors: Lamya Hamad, Thaer Khoury, Karen Vona, Jill Nestico, Mateusz Opyrchal, Kilian E Salerno
Journal: Cureus (2016)
Keywords: anthracyclines, brca1, breast cancer, metaplastic carcinoma, oncology, triple negative breast cancer
MeSH terms: Case Reports

Female breast cancer accounts for 14% of all new cancer cases in the United States. Metaplastic breast carcinomas (MpBC) are less than 1% of all mammary tumors. Limited clinical information exists on the prognosis and treatments for MpBC due to its rarity and the histological diversity of the tumor cells. We report a case of metastatic MpBC with osseous differentiation who had a marked response to liposomal doxorubicin. This 54-year-old female presented with a 2.5 x 2.6 cm oval-shaped irregularly marginated density in the outer lower quadrant of the left breast, cT2N0M0. Biopsy revealed an invasive metaplastic carcinoma, triple negative, with osseous and focal chondroid differentiation. Genetic testing showed a mutation in the BRCA1 gene. Approximately seven months after a left mastectomy, the patient presented with biopsy-proven metastatic disease and was initiated on therapy with a single agent, liposomal doxorubicin, 50 mg/m(2) every 28 days. The patient achieved maximum response after cycle three and continued to have stable disease for 18 months (20 cycles). Based on the pathologic phenotype, we would have predicted that she would have had a poor and short response to anthracycline. This case illustrates an increased sensitivity of BRCA1-mutated cancers to anthracycline therapies, irrespective of pathologic classification.
Boxer's Knuckle
Authors: Nina Watté, Luc Walschot, Filip Vanhoenacker
Journal: J Belg Soc Radiol (2021)
Keywords: boxer’s knuckle, dynamic ultrasound, magnetic resonance imaging, metacarpophalangeal joint
MeSH terms: Case Reports

Teaching Point: Persistent metacarpophalangeal joint pain after clenched-fist trauma with an unremarkable conventional radiography justifies further examination with dynamic ultrasound for detecting extensor hood injuries.
Multisystem Involvement Induced by Human Parvovirus B19 Infection in a Non-immunosuppressed Adult: A Case Report
Authors: Qihang Zou, Peisong Chen, Jiaxin Chen, Dingbang Chen, Han Xia, Ling Chen, Huiyu Feng, Li Feng
Journal: Front Med (Lausanne) (2022)
Keywords: case report, human parvovirus b19, immunosuppressed, mngs, multiple organ dysfunction
MeSH terms: Case Reports

Background:
Human parvovirus B19 (B19V) infection is usually symptomless and occurs in the childhood. While in immunocompromised adults, B19V infection also presents various clinical symptoms due to the host's immune status. The classic symptoms include erythema, anemia, arthropathy, and edema, but neurological involvement is rare.
Case presentation:
In this report, we present a case of B19V infection caused multiple organ dysfunction in a non-immunosuppressed adult. Metagenomic next-generation sequencing (mNGS) was used and successfully detected the pathogen in multiple types of samples, including blood, cerebrospinal fluid (CSF), and bronchoalveolar lavage fluid (BALF). The diagnosis was subsequently confirmed by polymerase chain reaction (PCR). He was treated with intravenous gamma globulin, resulting in a significant resolution of symptoms after 1 month.
Conclusion:
Multisystem involvement induced by B19V infection was found in this case report. mNGS performed great advantages in rapidly and accurately diagnosing B19V infection in multiple types of samples, which helps the timely adjustment of treatment and improves the prognosis.
"Everybody breastfeeds if they have milk": factors that shape exclusive breastfeeding practices in informal settlements of Mumbai, India
Authors: Sudha Ramani, Nikhat Shaikh, Sushmita Das, Shanti Pantvaidya, Armida Fernandez, Anuja Jayaraman
Journal: Int Breastfeed J (2019)
Keywords: exclusive breastfeeding, informal settlements, qualitative
MeSH terms: Breast Feeding / psychology, Milk, Human / metabolism, Research Support, Non-U.S. Gov't, Adolescent, Adult, Breast Feeding / economics, Breast Feeding / statistics & numerical data, Female, Health Knowledge, Attitudes, Practice, Health Promotion, Humans, India, Mothers / psychology, Perception, Qualitative Research, Young Adult

Background:
In India, though breastfeeding is universally practiced, exclusive breastfeeding (EBF) rates in urban informal settlements are low; and health programs face several challenges in promoting EBF. In this study, ensconced in one program area of a non-government organization, we focused on "positive deviant"- mothers who were able to practice EBF for six months and attempted to delineate factors that shaped their EBF practices. Typically, qualitative research from Lower and Middle Income countries on EBF has focused on understanding why women do not practice EBF; the converse perspective taken in this study has been less explored.
Methods:
We employed the positive deviance approach which contends that important programmatic learnings can be attained from persons who adopt positive behaviours. We conducted twenty-five diverse, purposively sampled case-studies of "positive deviant" mothers from two urban informal settlements in Mumbai; and analysed these using a framework approach. The results were summarised using a socioecological framework (consisting of individual, interpersonal, organizational and environment levels).
Results:
We found that mothers typically construed EBF as not giving breastmilk substitutes. Giving the infant minor supplements (water, honey) was not considered a violation of the EBF practice. The main themes that emerged as influencers of EBF included: at individual level, perceptions of having adequate milk; at interpersonal level, having role models who practiced EBF and having family support; at organizational level, advice from health workers (which was purported to play a secondary role); and at environmental level, financial constraints that limited access to supplements. One important finding was that women who practiced EBF could not always do it optimally; we encountered several instances of "poor EBF" practices, where mothers had breastfed infants inconsistently, allowing for long gaps between feeds, and had continued EBF even after six months.
Conclusions:
There is an urgent need for health programs to clarify the meaning of EBF and counsel against "poor EBF" practices. Messages received by women from immediate family on EBF were powerful and families play an important role in the actualization of optimal EBF practices. Hence, it is imperative to counsel entire families on EBF rather than women alone.
Compensatory orthodontic treatment of skeletal Class III malocclusion with anterior crossbite
Authors: José Valladares Neto
Journal: Dental Press J Orthod (2014)
Keywords: corrective orthodontics, crossbite, tooth extraction
MeSH terms: Malocclusion, Angle Class III / therapy, Orthodontics, Corrective / methods, Case Reports, Bicuspid / surgery, Cephalometry / methods, Diastema / therapy, Esthetics, Dental, Follow-Up Studies, Humans, Male, Mastication / physiology, Orthodontic Appliance Design, Orthodontic Space Closure / instrumentation, Orthodontic Space Closure / methods, Orthodontics, Corrective / instrumentation, Patient Care Planning, Smiling, Tooth Extraction / methods, Tooth Movement Techniques / instrumentation, Tooth Movement Techniques / methods, Vertical Dimension, Young Adult

Introduction:
This case report describes the orthodontic treatment of an adult patient with skeletal Class III malocclusion and anterior crossbite. A short cranial base led to difficulties in establishing a cephalometric diagnosis. The patient's main complaint comprised esthetics of his smile and difficulties in mastication.
Methods:
The patient did not have the maxillary first premolars and refused orthognathic surgery. Therefore, the treatment chosen was orthodontic camouflage and extraction of mandibular first premolars. For maxillary retraction, the vertical dimension was temporarily increased to avoid obstacles to orthodontic movement.
Results:
At the end of the treatment, ideal overjet and overbite were achieved.
Conclusions:
Examination eight years after orthodontic treatment revealed adequate clinical stability. This case report was submitted to the Brazilian Board of Orthodontics and Facial Orthopedics (BBO) as part of the requirements to become a BBO diplomate.
Low Level Laser Therapy to Reduce Recurrent Oral Ulcers in Behçet's Disease
Authors: D B Gandhi Babu, Sunanda Chavva, Shefali Waghray, Neeharika Satya Jyothi Allam, Marella Kondaiah
Journal: Case Rep Dent (2016)

Behçet's disease (BD) is a chronic, relapsing multisystemic vascular condition. Behçet's disease was described by Hulusi Behçet in 1937. This rare multisystem relapsing-remitting inflammatory disease is poorly understood but is thought to be an autoimmune inflammatory vasculitic process in a genetically predisposed population. Diagnosis of Behçet's disease is based on International Criteria of Behçet's Disease (ICBD). The present paper describes a case report of Behçet's syndrome where aphthous stomatitis was treated with low level laser therapy.
Farmers' perceptions on the causes of cassava root bitterness: A case of konzo-affected Mtwara region, Tanzania
Authors: Matema L E Imakumbili, Ernest Semu, Johnson M R Semoka, Adebayo Abass, Geoffrey Mkamilo
Journal: PLoS One (2019)
MeSH terms: Farmers, Glycosides / metabolism, Manihot / growth & development, Plant Roots / growth & development, Taste, Thiocyanates / metabolism, Research Support, Non-U.S. Gov't, Humans, Perception, Tanzania, Glycosides, Thiocyanates

In areas where konzo (a cassava cyanide related paralytic disorder) persists, the agronomic factors causing increased cyanogenic glucoside levels in cassava, during periods without water stress, are hardly known. However, through their assessment of cassava root toxicity, using its bitter taste, farmers may have noticed factors unrelated to water stress that additionally influence the cyanogenic glucoside content of cassava cultivated in these areas. Increased cassava root bitterness is often associated with an increase in cyanogenic glucoside levels, making it a good indicator of changes in root cyanogenic glucoside content. Bitter cassava varieties that are preferentially planted by people living in most konzo-affected areas, are an additional known contributor to high cyanogenic glucosides. It is water stress that further increases the inherent toxicity of the planted bitter cassava varieties. Using konzo-affected Mtwara region in Tanzania as a case study, a household survey was carried out to identify the overlooked agronomic factors that additionally influence cyanogenic glucoside levels in cassava cultivated in konzo-affected areas. A total of 120 farmers were interviewed and they mentioned a number of factors unrelated to water stress, as agronomic factors that influenced cassava root bitterness and hence cyanogenic glucoside production in cassava. The mentioned factors included; certain soil characteristics (14.2%), plant age at harvest (7.5%), poor weeding (0.8%), piecemeal harvesting (0.8%), and branch pruning (0.8%). The revealed factors constitute permanent environmental characteristics and crop management practices commonly used by farmers living in konzo-affected Mtwara region in Tanzania. The revealed factors could be contributing to increased cyanogenic glucoside levels in cassava, during periods without water stress in areas where konzo persists.
Case report: Clinical manifestations and genotype analysis of a child with PTPN11 and SEC24D mutations
Authors: Yuqi Miao, Jiahui Chen, Xiaoya Guo, Yu Wei, Xiaozhi Wu, Yanmei Sang, Di Wu
Journal: Front Pediatr (2022)
Keywords: cole-carpenter syndrome-2, leopard syndrome, ptpn11, sec24d, case report, dual mutations
MeSH terms: Case Reports

Background:
The PTPN11 gene, located at 12q24. 13, encodes protein tyrosine phosphatase 2C. Mutations in the PTPN11 gene can lead to various phenotypes, including Noonan syndrome and LEOPARD syndrome. The SEC24D gene is located at 4q26 and encodes a component of the COPII complex, and is closely related to endoplasmic reticulum protein transport. Mutations in SEC24D can lead to Cole-Carpenter syndrome-2. To date, dual mutations in these two genes have not been reported in the literature.
Methods:
We report a patient with short stature and osteogenesis imperfecta as the primary clinical manifestation. Other clinical features were peculiar facial features, deafness, and a history of recurrent fractures. Whole exome sequencing was performed on this patient.
Results:
After whole-exome sequencing, three mutations in two genes were identified that induced protein alterations associated with the patient's phenotype. One was a de novo variant c.1403C>T (p.Thr468Met) on exon 12 of the PTPN11 gene, and the other was a compound heterozygous mutation in the SEC24D gene, a novel variant c.2609_2610delGA (p.Arg870Thrfs*10) on exon 20 and a reported variant c.938G>A (p.Arg313His) on exon 8.
Conclusions:
Concurrent mutations in PTPN11 and SEC24D induced a phenotype that was significantly different from individual mutations in either PTPN11 or SEC24D gene. Personalized genetic analysis and interpretation could help us understand the patient's etiology and hence develop treatments and improve the prognosis of these patients.
Case Report: Tropheryma whipplei Hide in an AIDS Patient With Pneumocystis Pneumonia
Authors: Jun Yan, Binhai Zhang, Zhongdong Zhang, Jinchuan Shi, Shourong Liu, Jianjiang Qi, Mengyan Wang
Journal: Front Public Health (2021)
Keywords: hiv, ngs, pneumocystis pneumonia, tropheryma whipplei, case report
MeSH terms: Acquired Immunodeficiency Syndrome / complications, Pneumocystis carinii, Pneumonia, Pneumocystis / complications, Case Reports, Research Support, Non-U.S. Gov't, Adult, Humans, Male, Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use, Tropheryma / genetics, Trimethoprim, Sulfamethoxazole Drug Combination

Introduction:Pneumocystis pneumonia (PCP) is one of the most common opportunistic infections in HIV-infected patients. However, coinfection with Tropheryma whipplei is infrequent in AIDS patients with PCP. Case Presentation: We report a 28-year-old male AIDS patient coinfected with T. whipplei and Pneumocystis jirovecii diagnosed in the bronchoalveolar lavage. After sulfamethoxazole-trimethoprim and meropenem treatment, the patient showed clinical improvement in 2 weeks. Conclusion: Clinicians need to be alert to the occurrence of T. whipplei infection in AIDS patients with PCP and timely diagnosis and antibacterial treatments are essential. This case may help clinicians for timely diagnosis of the coinfection of T. whipplei and P. jirovecii in AIDS patients.
Tibial plateau fracture and RNA sequencing with osteogenesis imperfecta: a case report
Authors: Yixiao Chen, Guoqing Li, Liangchen Wei, Jian Weng, Su Liu, Mingxi Gu, Pei Liu, Yuanchao Zhu, Ao Xiong, Hui Zeng, Fei Yu
Journal: Front Endocrinol (Lausanne) (2023)
Keywords: rna transcriptome sequencing, diagnosis, osteogenesis imperfecta, surgery, tibial plateau fracture
MeSH terms: Fractures, Bone / epidemiology, Osteogenesis Imperfecta / complications, Osteogenesis Imperfecta / epidemiology, Osteogenesis Imperfecta / genetics, Tibial Plateau Fractures, Case Reports, Research Support, Non-U.S. Gov't, Adult, Humans, Male, Mutation, Collagen Type I, alpha2 Subunit

Osteogenesis imperfecta (OI) is a hereditary skeletal dysplasia with an incidence of approximately 1:15,000 to 20,000. OI is usually caused by the mutation of COL1A1 and COL1A2, which would encode the α-chain of type I collagen. OI is clinically characterized by decreased bone mass, increased risk of bone fragility, blue sclerae, and dentinogenesis.
Case presentation:
A 29-year-old male patient was diagnosed with right tibial plateau fracture caused by slight violence. Physical examination revealed the following: height, 140 cm; weight, 70 kg; body mass index (BMI), 35.71 kg/m2; blue sclera and barrel chest were observed. X-ray examination showed left convex deformity of the thoracic vertebrae with reduced thoracic volume. Laboratory examinations revealed a decrease in both vitamin D and blood calcium levels. Bone mineral density (BMD) was lower than the normal range. After the preoperative preparation was completed, the open reduction and internal fixation of the right tibial plateau fracture were performed. Meanwhile, whole blood samples of this OI patient and the normal control were collected for RNA transcriptome sequencing. The RNA sequence analysis revealed that there were 513 differentially expressed genes (DEGs) between this OI patient and the normal control. KEGG-enriched signaling pathways were significantly enriched in extracellular matrix (ECM)-receptor interactions.
Conclusion:
In this case, DEGs between this OI patient and the normal control were identified by RNA transcriptome sequencing. Moreover, the possible pathogenesis of OI was also explored, which may provide new evidence for the treatment of OI.
"Hair in the Bladder": An Unusual Finding
Authors: Luca Cindolo, Maida Bada, Roberto Bellocci, Piergustavo De Francesco, Pietro Castellan, Francesco Berardinelli, Fabio Neri, Luigi Schips
Journal: J Endourol Case Rep (2017)
Keywords: bladder, chronic indwelling catheter, intermittent catheterization, trichobezoar, trichotillomania, urinary tract infection
MeSH terms: Case Reports

Trichobezoar is a rare condition whereby a hairball is found in the human stomach or gastrointestinal tract, most frequently in young women, mainly in association with a psychiatric disorder. Trichobezoar cases have also been reported in the bladder and represent a rare complication of foreign bodies, called "hair nidus or hair ball," in patients with chronic catheter. Approximately 10% to 15% of patients on long-term urethral catheter or clean intermittent self-catheterization develop urinary tract stones. In a small minority of cases, bladder stones can develop around a foreign body that was introduced into the bladder. In the literature, there are few cases of foreign bladder bodies that formed stones over a hair nidus. Recognizing this condition can optimize the patient's quality of life. Herein, we present a case of a 71-year-old Caucasian male with a long-term catheter in hypocontractile urinary bladder secondary to injury of pelvic plexus after rectal surgery. He had a bladder stone caused by hair encrusted together. Hair is introduced into the bladder either by adherence to the catheter directly or by overlying the urethral meatus and being pushed internally. Regular hygiene and shaving of pubic area represent effective preventive measures to reduce this kind of complications in patients with chronic indwelling catheter or under a self-catheterization regimen.
Orthodontic management of a non-syndromic patient with concomitant bimaxillary hypohyperdontia: a case report
Authors: Ei Ei Hsu Hlaing, Yoshihito Ishihara, Atsuro Fujisawa, Takashi Yamashiro, Hiroshi Kamioka
Journal: Dental Press J Orthod (2020)
MeSH terms: Malocclusion, Angle Class II, Orthodontic Anchorage Procedures, Case Reports, Adult, Cephalometry, Esthetics, Dental, Female, Humans, Tooth Movement Techniques, Young Adult

Introduction:
Tooth agenesis is one of the most common dental anomalies; however, the concomitant occurrence of opposite dental numerical variation of hypohyperdontia is extremely rare.
Objective:
To report the successful orthodontic management of a patient with non-syndromic concomitant bilateral agenesis of mandibular canines and two midline inverted supernumerary maxillary teeth.
Case report:
21-year-old female patient with a chief complaint of protrusive right maxillary central incisor. The patient was diagnosed with a mild Class II skeletal base, Angle Class III molar relationship and increased overjet associated with hypohyperdontia. Anterior open bite accompanied with tongue-thrusting habit were also observed. Two temporary anchorage devices (TADs) were implanted at the buccal side of the maxillary molar region to control vertical height. Anterior teeth retraction was done after extraction of the maxillary first premolars, to improve the excessive overjet. The treatment mechanics involved lingual brackets system for the maxillary arch and transpalatal arch for anchorage control.
Results:
The total active treatment period was 35 months. Acceptable occlusion with increased bite force and contact area as well as functional excursion were established without interference, following complex orthodontic treatment with premolar substitution. The resultant occlusion and a satisfactory facial profile were maintained after 29 months of retention.
Conclusion:
The present case report provides implications regarding the orthodontic treatment of hypohyperdontia-associated substitution for missing teeth as an effective option for improving aesthetic and functional aspects.