OpenMed/multicare-articles huggingface dataset:
Pazopanib: a novel treatment option for aggressive fibromatosis
Authors: Gulcan Bulut, Anil Ozluk, Atike Pınar Erdogan, Ruchan Uslu, Nevra Elmas, Burcak Karaca
Journal: Clin Sarcoma Res (2016)
Keywords: aggressive fibromatosis, desmoid tumor, oral tyrosine kinase inhibitor, pazopanib
MeSH terms: Case Reports

Background:
Aggressive fibromatosis (AF), also known as desmoid tumor, is an uncommon soft tissue neoplasm. AF does not metastasize, but it is locally invasive and its propensity for recurrence after conservative resection is well documented. No effective cytotoxic treatment has been reported, hence there is a need for novel treatment strategies.
Case presentation:
We present the case of an AF successfully treated with an oral tyrosine kinase inhibitor, pazopanib, with mild side effects. As far as we know, this is the first case of AF with complete response to pazopanib.
Conclusion:
Pazopanib might be an effective treatment option for AF.
Hand-assisted laparoscopic nephrectomy in a high risk overweight donor with left-sided IVC, and previous abdominal surgery
Authors: Giuseppe Serena, Javier González, Leonardo E Garcia, Giselle Guerra, Mahmoud Morsi, Gaetano Ciancio
Journal: Int J Surg Case Rep (2019)
Keywords: left-sided inferior vena cava, living donor nephrectomy, operative complications, risk factors, venous anomalies

Introduction:
The extension of donor eligibility criteria represents one of the possible ways to increase the organ shortage, thus decreasing the waiting time for kidney transplantation. Expectedly, this strategy is associated with a growing number of more technically demanding living donor nephrectomy procedures requiring careful assessment, and sound surgical experience in order to avoid intraoperative complications.
Case presentation:
After a thorough evaluation through preoperative imaging, we performed a hand-assisted left laparoscopic living donor nephrectomy in a 56 year-old overweight patient with history of prior abdominal surgery, harboring a left-sided inferior vena cava (IVC).
Discussion/conclusion:
This case describes our comprehensive approach in this complex surgical scenario to preserve donor safety and provide an optimal kidney graft.
Urachal Carcinoma with Peritoneal Dissemination Treated with Chemotherapy and Surgical Resection Leading to Prolonged Survival with No Recurrence
Authors: Masato Yasui, Ryosuke Jikuya, Tomoyuki Tatenuma, Kentaro Muraoka, Susumu Umemoto, Masaki Kawai, Tsutomu Kouno, Takeshi Kishida
Journal: Case Rep Urol (2018)
MeSH terms: Case Reports

A 56-year-old man was admitted to our hospital for urachal carcinoma with peritoneal dissemination. He received first-line chemotherapy with gemcitabine and cisplatin. After the fifth cycle, a computed tomography (CT) scan revealed abdominal fluid, and his serum tumor marker levels were increased. The patient was started on second-line therapy with FOLFIRI. After 11 cycles, his tumor decreased in size and no new metastatic lesions were detected. The patient underwent complete tumor resection with partial cystectomy and pelvic lymph node dissection. The tumor was removed, along with adhering surrounding organs, including the omentum, peritoneum, abdominal rectus muscle, and vermiform appendix. Although pathological examination confirmed peritoneal dissemination, his tumor markers normalized soon after surgery. The patient has survived 62 months after surgery without any adjuvant therapy and with no evidence of recurrence. To our knowledge, this is the longest duration of survival without recurrence of a patient with urachal carcinoma with peritoneal dissemination who received multimodal therapy.
Pectus excavatum correction enhanced by pectoralis muscle transposition: A new approach
Authors: Beatrice Aramini, Uliano Morandi, Giorgio De Santis, Alessio Baccarani
Journal: Int J Surg Case Rep (2020)
Keywords: modified ravitch, pectoralis muscle flap transposition, pectus excavatum
MeSH terms: Case Reports

Background:
Indications for the surgical correction of pectus excavatum include functional/physiological, cosmetic, and psychosocial reasons. The most popular open technique for pectus excavatum repair was proposed by Ravitch in 1949 as an open approach that requires partial resection of the costal cartilage, xiphoid excision, and osteotomy of the sternum. The goal is to remove abnormal rib cartilage while preserving the perichondrium, allowing regrowth of the rib cartilage to the sternum in a more anatomic manner.
Operative technique:
We present a case of bilateral pectoralis muscle flap transposition during a modified Ravitch procedure is presented herein.
Conclusion:
This approach allows for a significant reduction in late complications and improves both functional and aesthetic outcomes.
Acute visual loss induced by dexamethasone during neoadjuvant docetaxol
Authors: D L Gregory, C D Jones, E R E Denton, A N Harnett
Journal: Clin Med Oncol (2008)
Keywords: central serous retinopathy, dexamethasone, docetaxol, steroid premedication, taxanes
MeSH terms: Case Reports

We present a case of a female patient who developed acute onset of visual loss due to central serous retinopathy as a consequence of steroid premedication for docetaxol given as second line neoadjuvant chemotherapy for breast cancer. Central serous retinopathy is a recognised association with steroids but has not been previously reported in association with the management of solid tumours. Reduction in steroid dose and duration permitted recovery of her visual acuity while allowing completion of the prescribed chemotherapy regimen. An overview of the presentation, pathogenesis, aetiologies and management of central serous retinopathy is given.
Colonic mucosa-associated lymphoid tissue lymphoma: A case report
Authors: Dan Chen, Ding-Fu Zhong, Yi Yang, Si-Shuang Chen, Dong Liu
Journal: Front Surg (2023)
Keywords: colonic mucosa–associated lymphoid tissue lymphoma, electronic staining endoscopy, magnifying endoscopy, pigmented endoscopy, treatment
MeSH terms: Case Reports

Background:
Mucosa-associated lymphoid tissue (MALT) lymphoma is a group of extranodal lymphomas that originate from B cells. Primary colonic MALT lymphoma is a rare disease, and there is no consensus on its endoscopic features and standard therapies. It is essential to raise awareness of colonic MALT lymphoma and choose the appropriate treatment.
Case presentation:
In this case report, we describe a 0-IIb-type lesion that was found by electronic staining endoscopy and magnifying endoscopy. The patient underwent a definitive diagnostic ESD for diagnosis. The patient was evaluated for lymphoma after diagnostic ESD according to the Lugano 2014 evaluation criteria, which are divided into imaging remission on the basis of CT and/or magnetic resonance imaging (MRI) evaluation and metabolic remission on the basis of PET-CT evaluation. Based on the PET-CT results suggesting increased glucose metabolism in the sigmoid colon, the patient underwent additional surgical treatment. According to the pathological results of the surgery, we found that ESD could treat such lesions, which may provide a new option for colorectal MALT lymphoma.
Conclusion:
The low incidence of colorectal MALT lymphoma, especially for 0-IIb lesions, which are difficult to detect, requires the use of electronic staining endoscopy to improve the detection rate. The combination with magnification endoscopy can improve the understanding of colorectal MALT lymphoma, which ultimately requires pathological support for diagnosis. According to our experience with the present patient case, ESD seems to be a feasible and economical choice for the treatment of massive colorectal MALT lymphoma. However, the combined application of ESD and another therapy scheme needs further clinical investigation.
Soft tissue sarcoma affecting the right shoulder of a man with paraplegia from a remote traumatic spinal cord injury: a case report
Authors: Colin K Franz, Kyriakos Dalamagkas, Lewis A Jordan, Gayle R Spill
Journal: Spinal Cord Ser Cases (2018)

Introduction:
People with spinal cord injury (SCI) are getting older due to a combination of increased life expectancy and older age at the time of injury. This trend makes it more likely for these patients to have other chronic health conditions including cancer. Inevitably relatively rare cancers such as soft tissue sarcomas (STS), which are more common with advancing age, will occur in some SCI patients. The present case represents the first report of a limb STS in a patient with chronic paraplegia from a traumatic SCI.
Case presentation:
We report a case of a 50-year-old right handed male with a T6 chronic, complete SCI (American Spinal Injury Association Impairment Scale A) who presented with a large mass involving his right shoulder musculature that was determined to be a high grade spindle cell sarcoma. The patient was followed closely by Physiatry over an approximately 6-month time course including prior to his tumor diagnosis, during the pre-radiation and pre-surgical planning phase, and then post-operatively for his acute inpatient rehabilitation. He was successfully discharged home to live alone in his accessible apartment complex.
Discussion:
This case is the first ever reported case of a person living with a traumatic SCI who subsequently developed a limb STS. In addition to its novelty, this case illustrates how health conditions such as rare cancers are presenting more often as the chronic SCI population is getting older, which creates both unique diagnostic and management challenges for cancer rehabilitation specialists.
Severe Agranulocytosis following Simultaneous Administration of Chlorpromazine and Trimethoprim-Sulfamethoxazole in a Patient with Sepsis: A Possible Toxic Combination
Authors: Anil Jha, Hassan Ghoz, Nicholas James
Journal: Case Rep Med (2016)

Background. Chlorpromazine and trimethoprim-sulfamethoxazole (TMP/SMX) are two commonly prescribed medications by physicians. Either of those medications could cause fatal drug-induced agranulocytosis, with an unclear underlying mechanism. The likelihood of simultaneous prescription of both medications is high and could hypothetically result in severe agranulocytosis that is resistant to treatment. Case Presentation. We are presenting a case of a patient with psychosis on chlorpromazine who was prescribed TMP/SMX for a urinary tract infection. Consequently, the patient developed severe agranulocytosis and septicemia. Patient was managed by granulocyte colony-stimulating factor; however, the time to neutrophil recovery was delayed when compared to the average reported time published by previous studies. Conclusions. Simultaneous use of chlorpromazine and TMP/SMX is a possible toxic combination that could induce severe agranulocytosis. Further reports are needed to confirm this observation.
Irreducible Knee Dislocation With Vastus Medialis Muscle Interposition: A Case Report
Authors: Nicolae Angan, Boris Feghiu, Nicolae Gheorghiu, Valentin Feghiu, Muhammad Usaama Bahadoor
Journal: Cureus (2023)
Keywords: complicated knee dislocation, irreducible knee dislocation, open reduction, posterolateral knee dislocation, vastus medialis interposition
MeSH terms: Case Reports

Irreducible knee dislocation (KD) is a rare high-velocity injury (determined by shear and/or rotational forces) that is associated with the interposition of capsule-ligamentous or muscle structures in the joint space. This condition often requires open reduction. To our knowledge, irreducible KD is not widely reported in the literature. Here, we report the case of a 69-year-old man with a right KD that occurred after falling from a height and entrapment of the leg between concrete blocks. The patient presented to the emergency department with a right knee deformity without distal neurovascular deficit. After two failed attempts of close reduction (under sedation and spinal anesthesia), open reduction was performed. Intraoperatively, there were cruciate ligament tears, wide capsule tears, and intra-articular vastus medialis interposition, preventing reduction. The decision to release the muscle from the notch, suture of the medial capsule, temporary K-wire stabilization, and cast immobilization were taken. After K-wire removal, the patient underwent rehabilitation to regain function and resume activities of daily living. This case report highlights the need for open reduction in some KD cases. Identifying possible soft-tissue interposition can accelerate surgical treatment and minimize the risk of complications.
Idiopathic membranous nephropathy with renal amyloidosis: A case report
Authors: Yue Wang, Xueyao Wang, Jinyu Yu, Shan Wu, Zhonggao Xu, Weixia Sun
Journal: Front Med (Lausanne) (2022)
Keywords: case report, idiopathic membranous nephropathy, phospholipase a2 receptor, renal amyloidosis, renal biopsy
MeSH terms: Case Reports

Background:
Immunoglobulin light chain amyloidosis is a clonal, non-proliferative plasma cell disorder, in which fragments of immunoglobulin light chain are deposited in tissues. Clinical features depend on organs involved but can include restrictive cardiomyopathy, nephrotic syndrome, hepatic failure, peripheral/autonomic neuropathy, and atypical multiple myeloma. Membranous nephropathy (MN) is a group of diseases characterized by deposition of immune complexes under the epithelial cells of glomerular basement and diffuse thickening of the basement membrane. Most patients with idiopathic MN (IMN) have been exposed to phospholipase A2 receptor (PLA2R) antigen, and anti-PLA2R antibodies that attack podocytes can be detected in their blood. IMN combined with amyloidosis nephropathy without secondary factors is rare. The present study describes a patient with IMN combined with immunoglobulin light chain amyloidosis nephropathy.
Case report:
A 39-year-old man was admitted to our hospital because of weight loss and edema. His clinical manifestation was nephrotic syndrome. Renal pathology revealed MN. A positive Congo red staining and the pathognomonic apple-green birefringence under cross-polarized light were considered to be associated with amyloid nephropathy. Immunofluorescence showed that λ light chain was positive. Heavy chain deposition disease and amyloid-associated protein amyloidosis were excluded by immunofluorescence and immunohistochemistry, respectively. Subsequent examinations showed that his serum was negative for antibodies against the PLA2R, but PLA2R was present in renal tissue. The final diagnosis was IMN with light chain amyloid nephropathy.
Conclusion:
Renal amyloidosis accompanied by IMN is uncommon. Attention should be paid to the subtype of the disease and the exclusion of secondary factors. Perfect clinical and pathological examination are helpful for the classification and staging of the disease. Congo red staining, light microscopy, immunofluorescence, immunohistochemistry, electron microscopic examination, pathological tissue staining for PLA2R antigen and testing for anti-PLA2R antibody in serum are helpful.
Toxic epidermal necrolysis associated with antiepileptic drugs and cranial radiation therapy
Authors: Shereen Elazzazy, Taghrid Abu Hassan, Ashraf El Seid, Cicy Mary Jacob
Journal: Case Rep Oncol Med (2013)

Case reports on the development of toxic epidermal necrolysis (TEN) associated with concurrent administration of phenytoin with cranial radiation therapy (Ahmed (2004), Criton et al. (1997), and Rzany et al. (1996)), but reports about erythema multiforme, which can develop in patients treated with levetiracetam and cranial irradiation, are very limited. This paper presents evidence that TEN may be induced by concurrent use of radiation with both phenytoin and levetiracetam. Our case is a 42-year-old male patient, a case of gliosarcoma who developed purpuric dermatitis associated with phenytoin when combined with cranial radiation therapy; although phenytoin was discontinued and switched to levetiracetam, the patient had more severe symptoms of toxic epidermal necrolysis (TEN) on levetiracetam; the patient improved with aggressive symptom management, discontinuation of antiepileptic drugs (AEDs), and holding radiotherapy. Although TEN is a rare toxicity, physicians should pay a special attention to the monitoring of brain tumor patients on antiepileptic prophylaxis during cranial irradiation; furthermore, patients should be counselled to notify their physicians if they develop any new or unusual symptoms.
Neonatal hepatitis as first manifestation of hyperimmunoglobulinemia d syndrome
Authors: Marie-Louise von Linstow, Vibeke Rosenfeldt
Journal: Case Rep Pediatr (2014)

Hyper IgD syndrome (HIDS) is a rare metabolic autoinflammatory syndrome characterised by recurrent febrile episodes, accompanied by various inflammatory symptoms. We present a case of severe HIDS in a young girl, whose symptoms started in the neonatal period with hepatomegaly, hepatitis, thrombocytopenia, and conjugated hyperbilirubinemia. From the age of five months, the child had recurrent febrile episodes, stomatitis, adenitis, and persistent hepatomegaly. The diagnosis of HIDS was established when she was three years and eight months old. This case report suggests that HIDS should be included in the differential diagnosis of neonatal hepatitis and conjugated hyperbilirubinemia.
Expansion of CD8+CD57+ T Cells in an Immunocompetent Patient with Acute Toxoplasmosis
Authors: R García-Muñoz, P Rodríguez-Otero, A Galar, J Merino, J J Beunza, J A Páramo, R Lecumberri
Journal: Adv Hematol (2009)
MeSH terms: Case Reports

CD57+ T cells increase in several viral infections like cytomegalovirus, herpesvirus, parvovirus, HIV and hepatitis C virus and are associated with several clinical conditions related to immune dysfunction and ageing. We report for the first time an expansion of CD8+ CD57+ T cells in a young patient with an acute infection with Toxoplasma gondii. Our report supports the concept that CD8+ CD57+ T cells could be important in the control of chronic phase of intracellular microorganisms and that the high numbers of these cells may reflect the continuing survey of the immune system, searching for parasite proliferation in the tissues.
Unilateral cataract and vitreoretinopathy in a case with klippel-trenaunay syndrome
Authors: Osman Okan Olcaysu, Ahmet Altun, Elif Olcaysu, Ebru Marzıoğlu Ozdemır, Berrin Demır
Journal: Case Rep Ophthalmol Med (2014)

Purpose. We present a case with Klippel-Trenaunay (KT) syndrome that had unilateral mature cataract and vitreoretinopathy. Case Report. A 17-year-old boy with KT syndrome presented to the clinic of ophthalmology for low vision in the right eye. His best corrected visual acuity (BCVA) was hand motion in the right eye and 20/20 in the left eye. Anterior segment examination revealed mature cataract in the right. During the physical examination, port-wine stains were noted over right side of his face, ankle, and toes. He had asymmetric face and his head was larger on the right side. Leg lengths were symmetrical, although he had skin hypertrophy. Cranial magnetic resonance imaging studies showed cortical atrophy discordant to his age, asymmetric vascular dilatations in the right hemisphere, hypertrophy in the right periorbital soft tissue, and choroidal plexus. The patient received an uncomplicated cataract surgery. His BCVA in the right eye improved to 20/200 after the surgery. After removing cataractous lens, we were able to examine the fundus that revealed severe vitreoretinopathy and choroidal hemangioma. Conclusion. This case emphasizes the importance of prompt ophthalmic examination in patients with KT syndrome.
First report of CTNS mutations in a Chinese family with infantile cystinosis
Authors: Yong-jia Yang, Yuan Hu, Rui Zhao, Xinyu He, Liu Zhao, Ming Tu, Lijun Zhou, Jihong Guo, Linqian Wu, Tantai Zhao, Yi-min Zhu
Journal: ScientificWorldJournal (2015)
MeSH terms: Amino Acid Transport Systems, Neutral / genetics, Mutation, Case Reports, Research Support, Non-U.S. Gov't, Cystinosis, Female, Humans, Infant, Male, Pedigree, Amino Acid Transport Systems, Neutral, CTNS protein, human

Infantile cystinosis (IC) is a rare autosomal recessive disorder characterized by a defect in the lysosomal-membrane transport protein, cystinosin. It serves as a prototype for lysosomal transport disorders. To date, several CTNS mutations have been identified as the cause of the prototypic disease across different ethnic populations worldwide. However, in Asia, the CTNS mutation is very rarely reported. For the Chinese population, no literature on CTNS mutation screening for IC is available to date. In this paper, by using the whole exome sequencing and Sanger sequencing, we identified two novel CTNS splicing deletions in a Chinese IC family, one at the donor site of exon 6 of CTNS (IVS6+1, del G) and the other at the acceptor site of exon 8 (IVS8-1, del GT). These data give information for the genetic counseling of the IC that occurred in Chinese population.
Aortic root replacement and valvuloplasty in a woman with severe pectus excavatum
Authors: Panagiotis Kalogris, Kosmas Iliadis, Gregory Amanatidis, Alexandros Demis, Anna Smyrli, Konstantinos Petsios
Journal: J Cardiovasc Thorac Res (2018)
Keywords: aortic root, marfan, pectus excavatum, valvuloplasty
MeSH terms: Case Reports

We describe a case of a 43-year old woman with Marfan's syndrome, tricuspid valve regurgitation and severe pectus excavatum who required an aortic root replacement and valvuloplasty for an ascending aortic aneurism with aortic valve regurgitation and tricuspid valve regurgitation. There was a severe angulation of the sternum which was close to 1.5 cm to the column vertebrae. Such cases are quite rare and always a challenge for surgeons to achieve adequate exposure of the heart and prevent excessive cardiac compression. We present our access, a safe and efficient exposure of the heart in order to achieve the best outcome.
POCUS Evaluation in Acute Kidney Injury
Authors: Vanessa A Hoytfox, Brittney C Ward, Emily J Cox, Kang X Zhang
Journal: POCUS J (2021)
Keywords: pocus, hydronephrosis, renal colic, ultrasound
MeSH terms: Case Reports

Acute kidney injury is a common clinical problem encountered in general internal medicine. The evaluation of acute kidney injury is mainly driven by the patient's clinical history, physical exam, and laboratory investigation including urinalysis and urine sediment examination. Point of care ultrasound (POCUS) may be a useful tool to help clinicians to narrow and/or prioritize differential diagnosis in patients presenting with acute kidney injury. Here we present a case of a 67-year-old male presenting with dysuria, fevers, and flank pain along with elevation in serum creatinine who was admitted with concern for acute kidney injury secondary to complicated urinary tract infection. Subsequent kidney POCUS of the kidneys and bladder showed bilateral anechoic fluid collection within the kidney sinus with dilated calyces suggestive of bilateral hydronephrosis, most likely due to a new diagnosis of benign prostatic hyperplasia. This case demonstrates the use of POCUS-obtained valuable diagnostic information and subsequent therapeutic management for this patient presenting with suspected acute kidney injury.