OpenMed/multicare-articles huggingface dataset:
Extensive necrotizing fasciitis of scrotum and abdominal wall: Report of two cases and a review of the literature
Authors: Zhe Meng, Yanchen Wang, Jun Chao, Yongjian Ji, Yaofei Sun, Jiang Zhu, Tongbin Gao, Si Chen, Shenyang Wang
Journal: Front Surg (2022)
Keywords: antibiotic, debridement, necrotizing fasciitis, vacuum sealing draina(vsd)
MeSH terms: Case Reports

The incidence rate of necrotizing fasciitis(NF) is low, but it has a high mortality rate. At present, it lacks experience in clinical treatment in municipal and county-level hospitals, insufficient awareness of disease risk, lack of experience in disease surgical intervention, and lack of a set of mature treatment norms and standards. Most patients have no time to transfer to a higher hospital for treatment. In January and April 2022, two cases of large-scale necrotizing fasciitis of the scrotum and abdominal wall were treated in the Department of Urology of Weifang people's Hospital respectively and were clinically cured after active surgical debridement combined with broad-spectrum antibiotics. Through the retrospective analysis of the diagnosis and treatment of two cases of necrotizing fasciitis, this paper analyzes and summarizes the scope of surgical debridement of NF, postoperative dressing changing skills, timing of multiple debridements, application and timing of vacuum sealing drainage(VSD), and the combined use of antibiotics. To provide experience for clinical diagnosis and treatment of necrotizing fasciitis.
Career adaptability of interpreting students: A case study of its development and interactions with interpreter competences in three Chinese universities
Authors: Sha Tian, Zhining Zhang, Lingxiao Jia
Journal: Front Psychol (2022)
Keywords: mti program, career adaptability, curriculum modification, interpreter competences, interpreting students

The issue of employability has already become a well-delineated topic of study among interpreting educators. However, the current literature still lacks descriptive research on interpreting students' employability development and ignores the developmental effects of interpreter competences in this process. Moreover, the advantage of using career adaptability for measurement is also under-researched. This exploratory case study aims at taking an initial step forward, surveying interpreting students' career adaptability development and the developmental effects of different interpreter competences on major adaptability resources, and ultimately diagnosing curriculum problems and making modifications accordingly. Thirty grade 2019 interpreting students from three Chinese universities contributed to data collection, through six questionnaires in a two-wave survey. The results highlight that, throughout the Chinese MTI program, interpreting students could become more concerned and well prepared for their future (concern), more curious to explore themselves and their surroundings (curiosity), and more capable of solving problems (confidence). The results also indicate that students' knowledge and language competence serve as the major facilitators in this process, and that other interpreter competences, such as psychological competence, transfer competence, professionalism, and cross-cultural competence, are also instrumental. In order to further boost their adaptability constructs, the results suggest that students' language and knowledge competence, professionalism, and cross-cultural and mental agility still need to be improved. Five suggestions for curriculum revision have been raised accordingly. As an initial effort, the current study will hopefully inspire further studies on interpreting students' career adaptability and add more knowledge to the curriculum design from this viewpoint.
Relapsing Malaria: A Case Report of Primaquine Resistance
Authors: Christopher Dijanic, Jillian Nickerson, Sunita Shakya, Amanda Dijanic, Marilyn Fabbri
Journal: Case Rep Infect Dis (2018)
MeSH terms: Case Reports

Primaquine (an 8-aminoquinoline malarial therapy) is the only FDA-approved therapy to treat the hypnozoite stage of P. vivax. We think of relapse occurring because of parasitic resistance or poor compliance secondary to drug toxicities. However, in patients with repeated treatment failure, we must consider CYP-450 mutations affecting drug metabolism as an important cause of relapse. A 47-year-old man who travelled to a jungle in Venezuela was diagnosed with P. falciparum and P. vivax in July 2015. He was treated with seven rounds of primaquine-based therapy in the following year, all resulted in relapse without further exposure to endemic areas. On his eighth presentation, he was found to have CYP-4502D6 mutation that affected the metabolism and activation of primaquine. Thereafter, he was treated without relapse. Primaquine efficacy depends on many factors. Understanding the mechanism responsible for malaria relapse is paramount for successful treatment and reduction in morbidity and mortality. This case illustrates the importance of considering cytochrome mutations that affect drug efficacy in cases of relapsing malaria.
Case Report: Liver Cysts and SARS-CoV-2: No Evidence of Virus in Cystic Fluid
Authors: Francesco Enrico D'Amico, Dajana Glavas, Giulia Noaro, Domenico Bassi, Riccardo Boetto, Enrico Gringeri, Maurizio De Luca, Umberto Cillo
Journal: Front Surg (2021)
Keywords: cov-2, fenestration cyst, jaundice, liver benign disease, liver cyst infection
MeSH terms: Case Reports

Background: In December 2019, an outbreak of pneumonia, caused by a new type of coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It quickly spread worldwide, resulting in a pandemic. The clinical manifestations of SARS-CoV-2 range from mild non-specific symptoms to severe pneumonia with organ function damage. In addition, up to 60% of patients have liver impairment or dysfunction, confirmed by several studies by the presence of SARS-CoV-2 in the liver tissue. Methods: We report two cases of symptomatic liver cyst requiring fenestration after recent SARS-CoV-2 infection. Both patients had hospital admission due to documented SARS-CoV-2 infection. Recently, after the infection, they developed symptoms caused by an enlarged hepatic cyst: one had abdominal pain, and the other had jaundice. They underwent surgery after two negative swab tests for SARS-CoV-2. Results: Cystic fluid was sent for microbiological test, and real-time fluorescence polymerase chain reaction COVID-19 nucleic-acid assay of the cyst fluid was found to be negative in both cases. Discussion: Although there are no current data that can document a viral contamination of cystic fluid, there are data that document a hepatotropism of COVID-19 virus. Herein we report that after viral clearance at pharyngeal and nasal swab, there is no evidence of viral load in such potential viral reservoir.
Massive ascites as the only sign of ovarian juvenile granulosa cell tumor in an adolescent: a case report and a review of the literature
Authors: Azin Ashnagar, Samin Alavi, Yalda Nilipour, Roxana Azma, Farahnaz Falahati
Journal: Case Rep Oncol Med (2013)

Ovarian neoplasms are relatively rare in childhood and adolescence; only 5% to 8% of the cases are of sex cord stromal origin. Granulosa cell tumors are a group of estrogen producing sex cord stromal tumors of the ovary. They occur in 95% of the cases in adults, and only about 5% of the cases, which differ in histologic characteristics, are of juvenile type. A 13-year-old girl is reported who presented with massive abdominal distention and ascites. An abdominopelvic computed tomography scan showed a predominantly cystic mass lesion with septations arising from the left ovary. All tumor markers were normal, but serum inhibin level was increased. The patient underwent mass resection with salpingoophorectomy. Histopathology was compatible with the juvenile granulosa cell tumor. Interestingly, menarche was started in the patient soon after the surgery. To the best of our knowledge, massive ascites as the only clinical manifestation in the juvenile granulosa cell tumor has not reported as yet.
Use of Nonabsorbable Spiral Tacks for Mesh Reinforcement in Thoracoscopic Repair of Congenital Diaphragmatic Hernia
Authors: Anna Poupalou, Celine Vrancken, Erwin Vanderveken, Henri Steyaert
Journal: European J Pediatr Surg Rep (2018)
Keywords: diaphragmatic hernia, patch, tack, thoracoscopy
MeSH terms: Case Reports

Thoracoscopic prosthetic repair of congenital diaphragmatic hernia (CDH) is a well-established and safe technique in experienced hands but the patching procedure is technically demanding and time consuming. To address the challenges associated with this process (confined working space and restricted time), the aim of this article is to assess the potential improvements in feasibility, efficacy, and safety of patch fixation by using nonabsorbable helicoidal tacks in neonates and infants for the repair of large CDH by thoracoscopy. The new technique has all the advantages of minimal invasive surgery in very young children combined with the advantages of reduced operating time and increased simplicity, and may be a good option in cases of recurrence.
Case report: Bilateral parotid abscess in a 54-day-old infant
Authors: Lilin Huang, Xiaole Yang, Shumei Peng, Ronghan Li
Journal: Front Pediatr (2023)
Keywords: staphylococcus aureus, infant, lymphadenitis, parotid abscess, surgical incision
MeSH terms: Case Reports

Acute parotid abscess (PA) is rare in children and is prone to occur in neonates or preterm infants with high-risk factors. Sporadic cases of unilateral PA have been reported in older children. Here, we report a case of a 54-day-old child who developed bilateral PA due to Staphylococcus aureus infection. The infant showed bilateral cervical lymphadenopathy initially following a 13-valent pneumococcal conjugate vaccine (PCV13). However, bilateral PA developed 6 h after he was diagnosed with lymphadenitis on Day 9 of illness. Rapid PA progression from cervical lymphadenitis is rare. He recovered quickly under treatment with appropriate antibiotics based on susceptibility testing and surgical incision and drainage.
Novel KAT6B-KANSL1 fusion gene identified by RNA sequencing in retroperitoneal leiomyoma with t(10;17)(q22;q21)
Authors: Ioannis Panagopoulos, Ludmila Gorunova, Bodil Bjerkehagen, Sverre Heim
Journal: PLoS One (2015)
MeSH terms: Histone Acetyltransferases / genetics, Leiomyoma / genetics, Nuclear Proteins / genetics, Retroperitoneal Neoplasms / genetics, Case Reports, Research Support, Non-U.S. Gov't, Amino Acid Sequence, Base Sequence, Chromosomes, Human, X / genetics, DNA Mutational Analysis, Female, HMGA Proteins / metabolism, Humans, Mediator Complex / genetics, Middle Aged, Molecular Sequence Data, Oncogene Proteins, Fusion / genetics, Sequence Analysis, RNA, Sex Chromosome Aberrations, HMGA Proteins, MED12 protein, human, Mediator Complex, NSL1 protein, human, Nuclear Proteins, Oncogene Proteins, Fusion, Histone Acetyltransferases, KAT6B protein, human

Retroperitoneal leiomyoma is a rare type of benign smooth muscle tumor almost exclusively found in women and with histopathological features similar to uterine leiomyomas. The pathogenesis of retroperitoneal leiomyoma is unclear and next to nothing is known about the cytogenetics and molecular genetics of the tumor. Here we present the first cytogenetically analyzed retroperitoneal leiomyoma. It had a t(10;17)(q22;q21) as the sole chromosomal abnormality. Using RNA-Sequencing and the 'grep' command to search the fastq files of the sequence data we found that the translocation resulted in fusion of the genes KAT6B (10q22) with KANSL1 (17q21). RT-PCR together with direct (Sanger) sequencing verified the presence of a KAT6B-KANSL1 fusion transcript. No reciprocal KANSL1-KAT6B transcript was amplified suggesting that it was either absent or unexpressed. The KAT6B-KANSL1 fusion transcript consists of exons 1 to 3 of KAT6B and exons 11 to 15 of KANSL1, is 3667 bp long, has a 1398 bp long open reading frame, and codes for a 466 amino acid residue protein. The corresponding KAT6B-KANSL1 protein contains the NEMM domain (including the linker histone H1/H5, domain H15) of KAT6B and the PEHE domain of KANSL1. The function of the fusion protein might be regulation of transcription with an affinity for chromatin (linker histone H1/H5) and interaction with the HAT domain of KAT8 (PEHE domain). The tumor expressed HMGA2 and HMGA1 even though 12q14-15 and 6p looked normal by G-banding analysis. The tumor also expressed MED12 in the absence of exon 2 mutations. Overall, the data show that the examined retroperitoneal leiomyoma resembles a subset of uterine leiomyomas in terms of histology and genetics.
Adenosquamous Carcinoma of the Pancreas in a Patient with BRCA2 Mutation: A Case Report
Authors: Vincent Yeung, Joshua D Palmer, Noelle Williams, Jonathan C Weinstein, Danielle Fortuna, Ashwin Sama, Jordan Winter, Voichita Bar-Ad
Journal: Case Rep Pancreat Cancer (2015)
Keywords: brca, adenosquamous, pancreas, platinum
MeSH terms: Case Reports

Background: Pancreatic adenosquamous carcinoma (ASC) is an uncommon subtype of pancreatic neoplasm, representing 1-4% of all pancreatic cancers. Given the rarity of this tumor, there is no well-established standard of care regarding treatment. We present the case of a BRCA2-deficient patient who responded tremendously well to a combination of gemcitabine and cisplatin therapy. Case presentation: A 66-year-old Caucasian man presented with a 2-week duration of progressively worsening clay-colored stools, tea-colored urine, and jaundice. Computed tomography scan of the abdomen revealed a 4-cm mass at the head of the pancreas. Preoperative carbohydrate antigen (CA) 19-9 was 255 U/mL (normal <37 U/mL). The patient underwent an uncomplicated pylorus-preserving pancreaticoduodenectomy with pathology revealing 11/12 positive lymph nodes, positive resection margins, perineural invasion, lymphovascular invasion, and positive disease in two distant perihepatic lymph nodes. The patient received one cycle of combination of gemcitabine and abraxane, was subsequently found to be BRCA2 deficient, and completed five cycles of gemcitabine and cisplatin thereafter. CA 19-9 before chemotherapy was 203 U/mL. Postchemotherapy CA 19-9 was 13 U/mL. As of today, the patient continues to do well 22 months postresection without radiographical or gross evidence of disease. Conclusion: Gemcitabine in combination with a platinum agent shows promise in the treatment of pancreatic ASC, particularly in setting of BRCA2 deficiency.
Primary appendiceal mucinous adenocarcinoma mimicking bladder carcinoma: A case report and review of the literature
Authors: Kai Deng, Cheng-Qi Zhang, Guang-Li Wang, Wei Li
Journal: Oncol Lett (2014)
Keywords: appendix, bladder carcinoma, invade, mucinous adenocarcinoma

Primary appendiceal mucinous adenocarcinoma is a rare entity, while appendiceal carcinoma invading the urinary bladder is even rarer. The current study presents the case of a 54-year-old male with primary appendiceal mucinous adenocarcinoma, without gastrointestinal symptoms, presenting only with signs of bladder irritation. Abdominal computed tomography scans demonstrated a mass at the right anterior level of the bladder. During intraoperative exploration, the mass was detected to connect and adhere to the ileocecal junction, and normal appendix tissues were not found. The frozen section revealed a mucinous adenocarcinoma of the appendix and the patient immediately underwent a subsequent hemicolectomy. The present case indicates that a diagnosis of a primary appendiceal mucinous carcinoma must considered by radiologists and clinicians for patients who do not exhibit gastrointestinal symptoms, but show involvement of the nearest organs and the bladder wall.
Erdheim-Chester Disease and Small Lymphocytic Lymphoma Collision Tumour Presenting as a Perirenal Mass
Authors: Antonio Maietta, Maryam Razmpoosh
Journal: Case Rep Pathol (2020)
MeSH terms: Case Reports

Background:
Erdheim-Chester disease is a rare histiocytic neoplasm associated with MAPK pathway mutations. Disease manifestation is variable often involving many different organs, mainly bone, retroperitoneum, the heart, and the central nervous system. Histological findings include foamy histiocytes in a fibrous stroma with scattered inflammatory infiltrate. Histiocytes are CD68 positive and S100 negative. Case Report. We report a case of Erdheim-Chester disease associated with small lymphocytic lymphoma presenting as a perirenal mass with a review of the recent literature.
Conclusions:
Erdheim-Chester disease rarely can be associated with other cancers, namely myeloid neoplasms. We report a case of Erdheim-Chester disease presenting with small lymphocytic lymphoma as a perirenal mass. The association of Erdheim-Chester disease with lymphoproliferative disorders needs to be elucidated.
Duodenal gangliocytic paraganglioma: A very rare cause for upper gastrointestinal bleeding: Case report with review of literature
Authors: Sardar Hassan Arif, Ayad Ahmad Mohammed, Rafil T Yaqo
Journal: Int J Surg Case Rep (2020)
Keywords: epithelial cells, gangliocytic paraganglioma, ganglion cells, gastrointestinal bleeding, spindle cells
MeSH terms: Case Reports

Introduction:
Gangliocytic paraganglioma is a rare tumors mainly arises from the second part of the duodenum. The tumor is generally benign, but some cases are associated with lymph node or distant metastasis. It must be differentiated from other tumors. The main treatment is good local surgical resection. Most patients have good prognosis after an appropriate resection.
Case presentation:
A 47-year-old male patient presented with recurrent attacks of epigastric pain and melena. The general examination revealed pallor with no jaundice. The abdomen was soft with no tenderness. There were no stigmata of chronic liver diseases. The hemoglobin level was 8 gm/dl with normal liver and renal functions. The patients received compatible blood. Endoscopy showed a large pedunculated polyp with ulceration in the second part of the duodenum just distal to ampulla of Vater. During surgery, the anterior wall of duodenum was opened, and a 4 cm pedunculated polyp was excised which was arising from the posterior wall of the duodenum just distal to the ampulla of Vater. The frozen section examination revealed a benign lesion. The final histopathology result was consistent with the diagnosis of gangliocytic paraganglioma. The patient had smooth post-operative recovery and no postoperative complications.
Conclusions:
Gangliocytic paraganglioma is a rare tumor which mostly affects the second part of the duodenum. The tumor is considered benign but the possibility of the malignancy with lymphatic and distant metastases must be excluded before any surgery. The management plan must be addressed carefully and continuous follow up is recommended.
Plunging ranula: a case report
Authors: Ambika Gupta, F R Karjodkar
Journal: ISRN Dent (2011)
MeSH terms: Case Reports

Plunging ranulas, also known as deep, diving, cervical or deep plunging ranula, usually appear in conjunction with oral ranula. Rarely, these ranulas may arise independent of oral swelling. A rare case of plunging ranula without oral swelling is discussed along with review of literature.
A Rare Case of Raoultella planticola and Enterococcus casseliflavus Coinfection
Authors: Varsha Prasad, Baina Barouni, Bashar Khiatah, Musab Saeed
Journal: Case Rep Infect Dis (2022)
MeSH terms: Case Reports

Raoultella planticola, a Gram-negative bacterium, is a nonmotile rod usually found in soil and aquatic environments. It can be found in association with gastrointestinal malignancy. Enterococcus casseliflavus is a rare vancomycin-resistant Enterococcus that is responsible for some bacteremia. Our case describes a unique presentation of colonization with both R. planticola and E. casseliflavus isolated from the biliary stent isolates of a patient with known pancreatic malignancy and concomitant E. casseliflavus bacteremia. This is the first case ever reported of infection with both species.
Goodpasture's Syndrome and Silica: A Case Report and Literature Review
Authors: James Dahlgren, Marla Wardenburg, Trevor Peckham
Journal: Case Rep Med (2010)
MeSH terms: Case Reports

We report a case of Goodpasture's syndrome following chronic low level and an acute, high level of exposure to crystalline silica. A 38-year-old male tilesetter was admitted to the emergency room with dyspnea and respiratory failure. He reported that his symptoms had developed over the previous week after inhaling a large amount of dust while dry-sanding and sweeping a silica-based product used to fill cracks in a cement floor. Over the following days, his pulmonary function declined and he developed acute renal failure. Tests of antiglomerular basement membrane antibody were positive and renal biopsy revealed global glomerulonephritis. He was diagnosed with Goodpasture's syndrome and treated with steroids, plasmapheresis, and hemodialysis. This man had a history of childhood asthma and a remote, one pack-year history of cigarette use. He used the flooring product for seven years prior to the inciting event, however, previous jobs had utilized significantly smaller amounts. Goodpasture's syndrome and other autoimmune diseases have been reported in association with silica exposure. The acute onset following high level silica exposure in this previously healthy man, suggest that clinicians should investigate silica exposure as a causal factor in cases of Goodpasture's syndrome.
A straight pin foreign body in a child: ingested or aspirated?
Authors: Xicheng Deng, Jinghua Wang, Renwei Chen, Peng Huang, Pingbo Liu, Xinyou Luo
Journal: Springerplus (2016)
Keywords: airway, child, foreign body, surgery

Background:
Though foreign body (FB) aspiration or ingestion is not uncommon in children, a straight pin as the culprit FB is rarely seen. The nature of such a FB makes it sometimes difficult to diagnose and deal with, especially in children.
Case report:
Here we present such a case who was initially misdiagnosed with FB ingestion but turned out to be an aspiration case. Moreover, its remote location from the hilum made a more invasive surgical retrieval inevitable. A thoracotomy was finally performed to retrieve the pin. And the postoperative course was uneventful.
Conclusion:
For pediatric FB cases, especially in such a case, it is very important to diagnose timely and accurately. A multidisciplinary team approach would facilitate prompt and accurate diagnosis and potentially simplify treatment.
Digit loss due to Demodex spp. infestation in a dog: clinical and pathological features
Authors: F Grandi, A Pasternak, H E O Beserra
Journal: Open Vet J (2013)
Keywords: acaricidal treatment, canine, parasite, pododemodicosis, skin
MeSH terms: Case Reports

Here we describe a rare clinical manifestation of canine pododemodicosis. A dog was presented with pedal erythema, scaling, crusting, severe edema and digit loss. The following diseases were taken into account for the differential diagnosis: pododemodicosis, lethal acrodermatitis, zinc responsive dermatosis and pemphigus foliaceus. Results from skin biopsies revealed the presence of Demodex spp. of mites in the follicular infundibula and a severe inflammatory process (pododemodicosis). Upon the acaricidal treatment, the patient exhibited favorable signs of clinical improvement.