OpenMed/multicare-articles huggingface dataset:
COVID-19 infection during autoimmune disease: study of 2 cases in Republic of Guinea
Authors: Kaba Condé, Hugues Ghislain Atakla, Mahaman Salissou Garba, Idé Garba
Journal: Pan Afr Med J (2020)
Keywords: covid-19, guinea, rheumatoid arthritis, systemic scleroderma
MeSH terms: Arthritis, Rheumatoid / virology, COVID-19 / complications, Scleroderma, Systemic / virology, Case Reports, Arthritis, Rheumatoid / immunology, COVID-19 / diagnosis, COVID-19 / immunology, COVID-19 Nucleic Acid Testing, Female, Guinea, Humans, Male, Middle Aged, Retrospective Studies, Scleroderma, Systemic / immunology

Introduction:
Coronavirus is a virus that can target the respiratory, musculoskeletal systems with a cascade of inflammatory processes. The objective of this work is to establish the link between autoimmune diseases and a COVID-19 infection in Guinea.
Methods:
Retrospective patient data were obtained from medical records. Informed consent was obtained under the direction of the national health security agency (ANSS).
Results:
We report the case of two patients aged 52 and 64 years respectively, known to have rheumatoid arthritis (RA) and systemic scleroderma (SDS) admitted with clinical signs suggesting underlying infection with COVID-19. They were tested with RT-PCR, which was positive within hours.
Conclusion:
In view of the rapid clinical worsening of patients with COVID-19 infection and autoimmune diseases, increased surveillance should be undertaken with abstinence of any factors that might weaken the immunity of these patients.
Case report: Colonic bezoar due to Box Myrtle seeds: A very rare occurrence
Authors: Narvir Singh Chauhan, Dinesh Sood
Journal: Indian J Radiol Imaging (2011)
Keywords: box myrtle, colonic bezoar, hyperechoic arc, kaiphal, seed bezoar, sigmoid stricture
MeSH terms: Case Reports

Large bowel seed bezoars are rare and are mostly due to seeds of sunflower, prickly pear cactus, sesame and cucumber. We present a rare case of sigmoid colon seed bezoar due to Box Myrtle seeds because of an underlying benign stricture.
Chondrosarcoma Arising from the Posterior Iliac Crest Extending into the Spinal Canal
Authors: Kota Wada, Akio Sakamoto, Rei Kato, Takashi Noguchi, Takayoshi Shimizu, Bungo Otsuki, Koichi Murata, Shunsuke Fujibayashi, Shuichi Matsuda
Journal: Case Rep Orthop (2021)
MeSH terms: Case Reports

Chondrosarcoma is a malignant tumor characterized by the production of a cartilage matrix. Extension into the spinal canal from the extracannular space is seen mainly for neurogenic tumors, but it is rare in nonneurogenic tumors. A 75-year-old woman suffered from sciatic pain and numbness in her lower left extremity. The diagnosis was of a low-grade conventional chondrosarcoma, which originated from the posterior ilium with an intraspinal extension at the level of the sacrum, compressing the cauda equina. The tumor extended further into the S1 sacral anterior foramen, in the shape of a dumbbell. The tumor was resected in several blocks posteriorly, and the dumbbell-shaped tumor in the S1 foramen was resected by widening the S1 foramen from behind. The posterior extension of the iliac tumor seemed prevented by the posterior sacroiliac ligament, and the tumor extended into the canal. Here, we report that the iliac chondrosarcoma extending into the spinal canal is rare for this tumor type. An understating of the tumor extension is important for planning the surgical strategy.
Systemic sclerosis manifesting as intractable gastro-oesophageal reflux and diarrhoea: a case report from Kenya
Authors: Gloria Wangechi Mugo, Eric Mwenda Murunga
Journal: Pan Afr Med J (2021)
Keywords: kenya, systemic sclerosis, case report, gastrointestinal system
MeSH terms: Diarrhea / etiology, Gastroesophageal Reflux / etiology, Scleroderma, Systemic / diagnosis, Case Reports, Aged, Deglutition Disorders / etiology, Female, Humans, Kenya, Scleroderma, Systemic / complications, Scleroderma, Systemic / therapy

Systemic sclerosis is a rare condition that has not been well reported in Africa, and several multisystemic manifestations, including gastrointestinal ones, have not been well documented locally. We present an unusual case of persistent gastro-oesophageal reflux and diarrhoea in a 74-year-old Kenyan female, who progressively developed abdominal distention, dysphagia and Raynaud´s phenomenon. Stool tests were unremarkable, whereas antinuclear antibody, ribonucleoproteins antibody (anti-nRNP/Sm) and anti-Sjögren's-syndrome-related antigen A autoantibody (anti-SSA) tests were positive. Endoscopic and imaging investigations revealed features of gastrointestinal dysmotility including reflux oesophagitis, gastroparesis and chronic intestinal pseudo-obstruction. A diagnosis of systemic sclerosis was made, and she responded well to medical treatment. We present this case to contribute to the limited literature of a disease associated with high morbidity and mortality, as well as encourage fellow clinicians to have a high level of suspicion in their differentials of persistent gastrointestinal dysmotility.
Accessibility calculation and equality evaluation of medical facilities for COVID-19 pandemic treatment: A case study of the Wuhan metropolitan development zone
Authors: Xiumei Shen
Journal: PLoS One (2022)
MeSH terms: COVID-19 / epidemiology, Catchment Area, Health, China / epidemiology, Cities, Health Services Accessibility, Humans, Pandemics / prevention & control

Medical facility equality is a critical metric for determining equal access to medical care. Their spatial distribution is important for effective pandemic treatment and daily prevention in cities. This paper used the Kernel Density Two-Step Floating Catchment Area (KD2SFCA) and shortest distance methods to calculate the accessibility of designated COVID-19 Fangcang hospitals and fever clinics in the Wuhan Metropolitan Development Zone. Their equality was evaluated by the Gini coefficient and Lorentz curve. Several results were obtained: (1) The facilities' accessibility declines radial from the central to peripheral areas. (2) Most of the demand points in the study area can reach the medical facilities for COVID-19 pandemic treatment within 60 minutes. (3) For the spatial distribution of these facilities, the equality evaluated for different time thresholds differed significantly, with long time thresholds having better equality than for short time thresholds. (4) While the distances distribution of fever clinics is balanced, the equality gap in various areas remains enormous when considering population distribution. Suggestions for optimizing the spatial distribution of pandemic treatment medical facilities in Wuhan are proposed, and which will serve as references for the planning of Wuhan's pandemic medical facilities in the future.
A Case of Ovarian Dysplasia and a Vaginal Fibroleiomyoma in a Young Golden Retriever
Authors: Samantha McCarter, D Phillip Sponenberg, Geoffrey Saunders, Julie Cecere
Journal: Front Vet Sci (2021)
Keywords: disorder of sexual development, dog, hyperplastic granulosa cells, ovarian dysplasia, persistent estrus, vaginal fibroleiomyoma
MeSH terms: Case Reports

This case demonstrates a unique ovarian congenital anomaly that likely contributed to the development of a rare fibroleiomyoma in the cranial vagina of a young bitch. A 13 month old intact female Golden Retriever presented to the veterinary teaching hospital for urinary incontinence, hematuria, and persistent vaginal discharge. Physical examination revealed a mucopurulent serosanguinous malodorous vulvar discharge, and after further diagnostics was reclassified as persistent estrus. Abdominal palpation and ultrasound revealed uterine thickening and poorly visualized ovaries. The reproductive tract was removed during an ovariohysterectomy, revealing small ovaries and a white anterior vaginal mass. Histopathology revealed dysplastic ovaries with hyperplastic granulosa cells and a benign vaginal fibroleiomyoma. These morphologic changes are consistent with elevated estrogen levels. It was thus concluded that her persistent estrus and the fibroleiomyoma were both secondary to persistent estrogen production by the hyperplastic granulosa cells.
A novel SLC8A1-ALK fusion in lung adenocarcinoma confers sensitivity to alectinib: A case report
Authors: Ling Deng, Panwen Tian, Zhixin Qiu, Ke Wang, Yalun Li
Journal: Open Life Sci (2022)
Keywords: alk fusion protein partners, slc8a1-alk, alectinib, lung adenocarcinoma
MeSH terms: Case Reports

ALK fusion genes are diverse. Approximately 30 different ALK fusion protein partners have been described previously, and some of these fusion proteins have been reported to be effective against ALK-tyrosine kinase inhibitor (TKI). ALK rearrangements often occur at a common breakpoint in exon 20 of the genome. SLC8A1-ALK, a novel fusion protein partner, comes from exon 2 of the SLC8A1 gene rearranged with exon 20 of the ALK gene. Here, we reported a patient with advanced lung adenocarcinoma harboring a SLC8A1-ALK fusion who benefited from first-line treatment with alectinib. After 2 months of taking alectinib, the targeted lung lesions and intrahepatic metastases regressed significantly. To date, the patient has achieved nearly 1 year of progression-free survival while taking the drug. Given the diversity of ALK fusion genes and the different efficacy of ALK-TKIs, we believe that this case report has an important clinical reference.
Severe methanol poisoning treated with a novel hemodialysis system: a case report, analysis, and review
Authors: Alisa C Illescas, Christos P Argyropoulos, Sara A Combs, Saeed K Shaffi, Zhi Q Xu, Michael A Aragon, J Pedro Teixeira
Journal: Ren Replace Ther (2021)
Keywords: hemodialysis, hemodialysis delivery systems, kinetics, methanol poisoning, toxic alcohol
MeSH terms: Case Reports

In May and June 2020, an outbreak of methanol poisoning arose in the southwest United States linked to ingestion of contaminated hand sanitizer imported during the coronavirus disease 2019 pandemic, ultimately resulting in over a dozen hospitalizations and at least four deaths in New Mexico and Arizona. In this report, we describe one of these cases in which profound methanol intoxication was successfully treated with the Tablo® Hemodialysis System, the first reported case of toxic alcohol poisoning treated with this novel device. We carry out a formal regression analysis of the serial methanol levels obtained in this case to conservatively estimate that intermittent hemodialysis with Tablo achieved a clearance of methanol of 239 mL/min (95% confidence interval, 173-305 mL/min), a clearance that is well within the previously published standard of care. We conclude by reviewing both the treatment of toxic alcohol poisoning and the determinants of small molecule clearance with hemodialysis, emphasizing the importance of optimizing the dialytic treatment of intoxications with extended treatment times and the use of high-efficiency dialyzers.
Symptomatic cardiac metastases of breast cancer 27 years after mastectomy: a case report with literature review--pathophysiology of molecular mechanisms and metastatic pathways, clinical aspects, diagnostic procedures and treatment modalities
Authors: Darko Katalinic, Ranka Stern-Padovan, Irena Ivanac, Ivan Aleric, Damir Tentor, Nora Nikolac, Fedor Santek, Antonio Juretic, Stjepko Plestina
Journal: World J Surg Oncol (2013)
MeSH terms: Breast Neoplasms / surgery, Heart Neoplasms / secondary, Mastectomy / adverse effects, Postoperative Complications, Case Reports, Review, Breast Neoplasms / pathology, Combined Modality Therapy, Female, Heart Neoplasms / etiology, Heart Neoplasms / therapy, Humans, Middle Aged, Prognosis, Review Literature as Topic, Tomography, X-Ray Computed

Metastases to the heart and pericardium are rare but more common than primary cardiac tumours and are generally associated with a rather poor prognosis. Most cases are clinically silent and are undiagnosed in vivo until the autopsy. We present a female patient with a 27-year-old history of an operated primary breast cancer who was presented with dyspnoea, paroxysmal nocturnal dyspnoea and orthopnoea. The clinical signs and symptoms aroused suspicion of congestive heart failure. However, the cardiac metastases were detected during a routine cardiologic evaluation and confirmed with computed tomography imaging. Additionally, this paper outlines the pathophysiology of molecular and clinical mechanisms involved in the metastatic spreading, clinical presentation, diagnostic procedures and treatment of heart metastases. The present case demonstrates that a complete surgical resection and systemic chemotherapy may result in a favourable outcome for many years. However, a lifelong medical follow-up, with the purpose of a detection of metastases, is highly recommended. We strongly call the attention of clinicians to the fact that during the follow-up of all cancer patients, such heart failure may be a harbinger of the secondary heart involvement.
Case report: Surgery combined with extracorporeal membrane oxygenation for a patient with type A aortic dissection complicated with myocardial infarction after percutaneous coronary intervention
Authors: Junjian Yu, Wenbo Yu, Hui Zeng, Jianfeng Gao, Jianxian Xiong
Journal: Front Cardiovasc Med (2023)
Keywords: sun’s procedure, acute myocardial infarction, aortic dissection, case report, extracorporeal membrane oxygenation, percutaneous coronary intervention
MeSH terms: Case Reports

Background:
Aortic dissection (AD) is a severe cardiovascular disease characterized by aortic rupture, aortic valve insufficiency, aortic branch lumen stenosis, and occlusion. Acute ST-segment elevation myocardial infarction may be the primary manifestation when aortic dissection affects the coronary artery, leading to delayed or missed diagnosis of aortic dissection, and preventing patients from receiving timely and comprehensive treatment. Simultaneous aortic repair and coronary artery bypass grafting surgery are controversial because of their high mortality rates. Personalized and optimal treatment plans for patients should be taken seriously based on their different conditions and treatment options.
Case presentation:
A 42-year-old man who experienced 1 h of persistent precordialgia was admitted to a local second-level hospital for emergency treatment. Electrocardiogram (ECG) showed evidence of ST-segment elevation, and myocardial enzyme levels were CK-MB 18.35 ng/ml and troponin 0.42 ng/ml. The patient was treated for acute myocardial infarction (AMI) and urgently sent to the interventional catheter room. Coronary angiography showed stenosis of the starting part of the right coronary artery trunk. Thus, stent implantation was performed, and the stenosis section recovered patency; however, postoperative precordialgia was not alleviated. Computed tomography angiography (CTA) revealed a type A AD. The patient was immediately transferred to a higher-level hospital, underwent emergency surgery with cardiopulmonary bypass (CPB) ascending aorta replacement, SUN's procedure (total arch replacement and stented elephant trunk implantation), and simultaneous implantation of extracorporeal membrane oxygenation (ECMO), and regained consciousness within intensive care unit care. ECMO was discontinued when hemodynamics stabilized. The patient ultimately recovered well and was discharged.
Conclusion:
This case demonstrated that precordialgia is not limited to myocardial infarction but may also be accompanied by aortic dissection. Percutaneous coronary intervention (PCI) can timely and effectively restore coronary artery perfusion, strive for the opportunity of aortic repair surgery, and can overcome pump failure caused by myocardial infarction, cardiopulmonary bypass, heart block time, and myocardial ischemia-reperfusion injury. Personalized treatment is crucial for patients with complex type A aortic dissection.
The Relevance of the MCP Risk Polymorphism to the Outcome of aHUS Associated With C3 Mutations. A Case Report
Authors: Javier Lumbreras, Marta Subias, Natalia Espinosa, Juana María Ferrer, Emilia Arjona, Santiago Rodríguez de Córdoba
Journal: Front Immunol (2020)
Keywords: c3, mcp risk polymorphism, atypical hemolytic uremic syndrome, case report, de novo mutation
MeSH terms: Atypical Hemolytic Uremic Syndrome / genetics, Complement C3 / genetics, Membrane Cofactor Protein / genetics, Case Reports, Research Support, Non-U.S. Gov't, Atypical Hemolytic Uremic Syndrome / diagnosis, Child, Humans, Male, Mutation, Pedigree, Polymorphism, Single Nucleotide, CD46 protein, human, Complement C3, Membrane Cofactor Protein

Thrombotic microangiopathy (TMA) has different etiological causes, and not all of them are well understood. In atypical hemolytic uremic syndrome (aHUS), the TMA is caused by the complement dysregulation associated with pathogenic mutations in complement components and its regulators. Here, we describe a pediatric patient with aHUS in whom the relatively benign course of the disease confused the initial diagnosis. A previously healthy 8-year-old boy developed jaundice, hematuria, hemolytic anemia, thrombopenia, and mild acute kidney injury (AKI) in the context of a diarrhea without hypertension nor oliguria. Spontaneous and complete recovery was observed from the third day of admission. Persistent low C3 plasma levels after recovery raised the suspicion for aHUS, which prompted clinicians to discard the initial diagnosis of Shigatoxin-associated HUS (STEC-HUS). A thorough genetic and molecular study of the complement revealed the presence of an isolated novel pathogenic C3 mutation. The relatively benign clinical course of the disease as well as the finding of a de novo pathogenic C3 mutation are remarkable aspects of this case. The data are discussed to illustrate the benefits of identifying the TMA etiological factor and the relevant contribution of the MCP aHUS risk polymorphism to the disease severity.
Kimura's disease affecting multiple body parts in a 57-year-old female patient: a case report
Authors: Bo Yu, Guoxing Xu, Xiaofan Liu, Wen Yin, Hao Chen, Baoqing Sun
Journal: Allergy Asthma Clin Immunol (2019)
Keywords: eosinophils, immunoglobulin e, kimura’s disease, lymphocyte, multiple body
MeSH terms: Case Reports

Background:
Kimura's disease (KD) is a rare chronic inflammatory disease with unknown etiology. It usually manifests as a painless soft tissue mass or subcutaneous nodule on one side of the patient's head and/or neck and rarely affects multiple parts of the body. The disease is more common among young Asian males.
Case presentation:
A 57-year-old Chinese woman complained of multiple masses on her body surface. Ultrasonography was used to examine the retroperitoneal, bilateral neck, bilateral supraclavicular, bilateral axillary, and bilateral inguinal superficial lymph nodes. Enlargement of multiple lymph nodes was found in all areas. Many solid nodules were also found in the right parotid gland and right posterior neck area, respectively. Numerous solid nodules were seen on the left chest wall. Laboratory tests showed that the percentage of eosinophils in the whole blood was 39.40%, total immunoglobulin E (IgE) level was > 5000 kU/L, and serum special IgE to Phadiatop (inhaled allergens) and fx5 (food allergens) were 1.01 and 1.04 kUA/L, respectively. After a complete examination, the masses located in the right neck, retroauricular and left axillary regions, and left chest wall were resected directly. Postoperative pathological findings revealed KD.
Conclusions:
The case discussed in this study is extremely rare and did not meet the common affected areas and age characteristics of KD. This presentation can be used to improve disease awareness among physicians.
Transhiatal esophagectomy with gastric pull-up, pyloric exclusion and Roux-en-Y gastroenterostomy for the management of esophageal caustic injury
Authors: Edson Gonçalves Ferreira Junior, Philippos Apolinario Costa, Larissa Melo Freire Golveia Silveira, Nayane Carolina Pertile Salvioni, Bruna Menon Loureiro, Sandra Lúcia Lodi Peres, Thiago Jardim Pereira
Journal: Int J Surg Case Rep (2019)
Keywords: caustic ingestion, esophagectomy, gastric pull-up, roux-en-y gastroenterostomy

Introduction:
Ingestion of caustic materials can lead to digestive tube perforation involving the mouth, pharynx, esophagus and stomach (Vezakis et al., 2016 [1]). In this case report, the authors opted for gastric pull-up in a case of esophageal and pyloric stenosis secondary to caustic ingestion, and a Roux-en-Y gastroenterostomy in the lower portion of the gastric pull-up.
Presentation of case:
A 37 years-old male presented complaints of dysphagia, which had started 28 days before admission after the ingestion of a caustic liquid. An esophagogastroduodenoscopy was performed, and showed a complete occlusion of the esophagus, without the possibility of performing an esophagus dilatation or placing a nasoenteric tube. The option was made for a transhiatal esophagectomy with gastric pull-up, pyloric exclusion and Roux-en-Y gastroenterostomy. The patient was later admitted with a stenosis of the esophageal anastomosis, which was resolved after performing endoscopic dilatation.
Discussion:
The medical team opted to use the stomach for the reconstruction of the gastrointestinal transit due to less morbidity during manipulation of that organ, as well as safer anastomosis, when compared to the colon. In this case report, the esophagus and pylorus were generally compromised, however, with no apparent damage whatsoever in the stomach. Therefore, we opted to resect the esophagus and used the stomach to perform a gastric pull-up with the exclusion of the pylorus and reconstruction with a Roux-en-Y gastroenterostomy.
Conclusion:
The proposed surgery is an option when dealing with similar cases, where endoscopic dilatation is not an option, and there is an associated pyloric stenosis.
Hematemesis as Initial Presentation in a 10-Week-Old Infant with Eosinophilic Gastroenteritis
Authors: Varun Shetty, Kayla E Daniel, Anil Kesavan
Journal: Case Rep Pediatr (2017)
MeSH terms: Case Reports

Eosinophilic gastroenteritis is a rare condition characterized by eosinophilic inflammation in the gastrointestinal tract resulting in a variety of gastrointestinal symptoms. There is currently a dearth of information on this topic in the pediatric literature, as very few cases have been reported. In this report, we present a case of eosinophilic gastroenteritis in a 10-week-old patient with initial presenting symptom of hematemesis. To our knowledge, this is the youngest case reported in the literature and is unique in its initial presentation.
Refractory Head and Neck Lymphatic Malformation in Infants Treated With Sirolimus: A Case Series
Authors: Changhua Wu, Dan Song, Lei Guo, Liang Wang
Journal: Front Oncol (2021)
Keywords: head and neck, infant, lymphatic malformation, sclerotherapy, sirolimus

Background:
Extensive and complex head and neck lymphatic malformations (LMs) are challenging to manage through traditional therapy. The purpose of this retrospective study was to assess the efficacy and safety of sirolimus in infants with refractory head and neck LMs.
Methods:
Sirolimus was administered orally on a continuous dosing schedule. Patients were seen every month for the first three months and then subsequently every three months. The primary endpoints were safety and efficacy based on clinical and radiological evaluations.
Results:
Eight patients, refractory to standard care, were enrolled and received sirolimus continuously. After 12 months of follow-up, the response and safety to medication was evaluated: all patients experienced reductions in LMs bulk, ranging from modest to significant. Some minor adverse effects were reported: mouth sores, eczema, gastrointestinal reaction, dyslipidemia, and neutropenia.
Conclusion:
Sirolimus was efficient in children with refractory head and neck LMs and was well tolerated.