OpenMed/multicare-articles huggingface dataset:
Intravascular Large B-Cell Lymphoma
Authors: Mehdi Loukhnati, Fatima Ezzahra Lahlimi, Illias Tazi
Journal: Case Rep Hematol (2023)
MeSH terms: Case Reports

Intravascular large B-cell lymphoma (IVBCL) is a very rare and aggressive subtype of extranodal diffuse large B-cell lymphoma (DLBCL) involving the growth of lymphoma cells within blood vessels of all organ types. We present the case of a 55-year-old North-African man with no prior history of neoplastic disease presenting with weight loss and an isolated splenomegaly. Investigations led to the diagnosis of this disease. To the best of our knowledge, this is the first case recorded in Africa. Through this article, we discuss this case and outline the common presentation, paraclinical investigations, and treatment options of IVBCL.
Multiple benign metastasizing leiomyoma in the abdominal wall: a case report and literature review
Authors: Jiaqi Hu, Shuyuan Tian, Qing Pan, Yonghong Yu
Journal: Front Oncol (2024)
Keywords: ceus, abdominal wall, benign metastasizing leiomyoma, myomectomy, smooth muscle cell
MeSH terms: Case Reports

Benign metastasizing leiomyoma (BML) is a rare disease that results from metastasis of uterine leiomyoma to distant sites with benign pathologic features. The lung is the most common metastatic site for BML. This report describes the case of a 49-year-old woman who presented with a mass in the abdominal wall with a surgical history of uterine myomectomy. Ultrasound and Magnetic resonance imaging (MRI) revealed multiple mass lesions. The histopathology of the mass specimen indicated BML. The imaging and clinical features of BML are discussed based on the characteristics of this case and related literature reports.
Presidents and vaccines: head of state inoculation as a tool for vaccine promotion
Authors: Lara Collart, Elie Lunanga, Nik Stoop, Marijke Verpoorten
Journal: Front Public Health (2024)
Keywords: democratic republic of congo, immunization, institutional trust, public health, vaccine hesitancy
MeSH terms: COVID-19 Vaccines, COVID-19 / prevention & control, Vaccination Hesitancy / psychology, Vaccination Hesitancy / statistics & numerical data, Adult, Democratic Republic of the Congo, Female, Health Promotion / methods, Humans, Immunization Programs, Leadership, Male, Middle Aged, Politics, SARS-CoV-2, Surveys and Questionnaires, Vaccination, COVID-19 Vaccines

Introduction:
Vaccine hesitancy, an important threat to global health, has increased since the onset of the COVID-19 pandemic. The public vaccination of high-profile figures, such as heads of state, has been touted as a potential tool for increasing vaccine acceptance among the general population. However, systematic information on such role modelling is lacking and existing studies focus on a small number of high-income countries. We take advantage of the COVID-19 pandemic to fill this gap.
Methods:
Through a systematic search of internet sources, we first document that most global leaders supported the vaccination campaign and actively communicated their vaccination status to the public. We then turn to a case study to provide experimental evidence on vaccine role modelling for a country in Africa - the region that is most lagging behind in achieving universal immunization coverage. We rely on a randomized survey experiment with 600 citizens in the Democratic Republic of Congo and take advantage of the fact that the Congolese President publicly received a COVID-19 vaccine during the survey period.
Results and discussion:
Our findings demonstrate that the impact of political leader's role modelling is moderated by trust and depends on media outreach and access. When trust in leaders is lacking, or news on their actions is inaccessible, alternative ambassadors and effective communication methods become crucial in motivating and informing the public. This may be especially relevant in fragile states and remote regions.
A Case Report of Whitmore's Disease: A True Masquerader
Authors: Chandrashekar Patil, Nikhitha Mangalagiri, Prakash Ajmera, Prashanth Kumar Ks, Haritha Reddy
Journal: Cureus (2024)
Keywords: burkholderia pseudomallei, cavitatory lung nodules, retrospective diagnosis, septicemia, thoracic melioidosis
MeSH terms: Case Reports

Melioidosis is an uncommon bacterial infection that is endemic to countries like Southeast Asia and Northern Australia but less common in temperate zones than when seen in returned travelers. This disease can affect almost every organ, with the lung being the most common organ to be involved. Here, we present a 21-year-old diabetic male who came with complaints of fever, nonproductive cough, and sore throat with grade III-IV shortness of breath. Laboratory investigations revealed hypokalemia and isolates of Burkholderia pseudomallei on blood culture and sensitivity. High-resolution computed tomography (HRCT) of the chest showed widespread, variable-sized nodules with central cavitations diffusely scattered in bilateral lungs.
Technique notes on the management of superior sagittal or transverse sinus during the falcotentorial meningioma surgery: a case report
Authors: Jun Liu, Di Fan, Ligang Chen, Zheng Zou, Xinning Li, Minghao Zhou, Zhongcheng Wen, Shun Gong, Guobiao Liang
Journal: Front Neurol (2024)
Keywords: approach, confluence sinuses, meningioma, technique note, venous bleeding
MeSH terms: Case Reports

Background:
Falcotentorial meningiomas (FM) are surgical challenges for protecting sinus, and the technique notes on the management of superior sagittal or transverse sinus are required for good results.
Methods:
We improved the technique notes on the management of superior sagittal or transverse sinus in three FM patients with signs of increased intracranial pressure or chronic headache.
Results:
All patients underwent surgeries in the prone position, and occipital/sup-occipital/sub-occipital craniotomy was performed. In one patient, the skull was removed traditionally with exposure of the confluence of sinuses, superior sagittal, and transverse sinus, while the longitudinal skull bridge was left to suspend the dura for protecting the superior sagittal sinus in one patient, and the transverse skull bridge was left to suspend the dura for protecting the transverse sinus in one patient. The dura was opened infratentorially or supratentorially to spare the sinus and then the "skull bridge" was suspended. The tumor was then removed completely without brain swelling or significant venous bleeding. Complete tumor resection was confirmed by early postoperative imaging, and all patients recovered well without postoperative morbidity.
Conclusion:
The authors recommend the "skull bridge" to suspend the dura for optimal control of the venous sinuses during FM surgery (less venous bleeding).
The Zurkurnai ECG Pattern: A Novel ECG Pattern of the High-Risk Features of Acute Pulmonary Embolism
Authors: Mohd Khairi Othman, Zurkurnai Yusof, Zul Khairul Azwadi Ismail, Khairil Amir Sayuti, W Yus Haniff W Isa
Journal: Cureus (2024)
Keywords: acute pulmonary embolism, mc connels sign, pseudo wellen, right ventricular dysfunction, zurkurnai ecg pattern
MeSH terms: Case Reports

Acute pulmonary embolism is an important differential diagnosis in patients presenting with acute shortness of breath. However, the overlapping clinical presentation between acute coronary syndrome, aortic dissection, pneumonia, and heart failure made the diagnosis of pulmonary embolism very challenging in a limited resources center. We present a case of acute pulmonary embolism with an uncommon ECG pattern that was initially misdiagnosed as acute coronary syndrome. The authors made the appropriate diagnosis using the Zurkurnai ECG pattern in acute pulmonary embolism, which is defined as the presence of right axis deviation, deep symmetrical T wave inversion in V1 to V5, II, III, and AVF with the maximum at V3-V4 and poor R wave progression, which indicates the high-risk features of acute pulmonary embolism.
Virtual surgical planning/3D printing assisted fibula osteoseptocutaneous flap combined with anterolateral thigh flaps for extensive composite oromandibular defects reconstruction: a retrospective study of case series
Authors: Yaoxiang Xu, Yali Li, Wenlin Xiao, Jin Yue, Lingfa Xue, Li Li, Zexian Xu, Jian Sun
Journal: Front Bioeng Biotechnol (2023)
Keywords: 3d printing, flap transplantation, multipleflap, reconstructive surgery, virtual surgical planning

Oromandibular tumors or osteoradionecrosis often lead to extensive composite defects encompassing intraoral, bone and extraoral tissues. A single flap cannot simultaneously offer sufficient bone and soft tissue. The combination of free flaps could be a prospective approach to overcome the challenge. The study aims to assess the efficacy of virtual surgical planning (VSP) and 3D printing assisted fibula osteoseptocutaneous flap (FOSCF) combined with anterolateral thigh flaps (ALT) in reconstructing extensive composite defects in the oromandibular region. A retrospective analysis was conducted on 8 patients who underwent reconstruction using FOSCFs combined with ALTs. Post-surgical excision of the lesions, we obtained mean values for the defects of intraoral soft tissue, bone, extraoral soft tissue, namely, being 42.7 cm2, 96 mm, and 68.9 cm2. The mean surgical procedures took 712.5 min. A total of 16 flaps were harvested and transplanted for the 8 patients, with all successfully surviving. Postoperatively, complications manifested as localized intraoral infections in 2 cases, intermuscular vein thrombosis in another 2 cases, and pulmonary infections in 2 patients. Two patients unfortunately experienced tumor recurrence, at 12 and 3 months post-operation respectively. For the surviving 6 patients, the average follow-up period was 12.2 months. Regarding patient satisfaction, one expressed dissatisfaction with the contour of the mandible, and two exhibited moderate trismus. Objective assessments identified 1 case of oral incontinence and 2 cases where external flap contractures were observed. All 8 patients experienced restoration of masticatory function and were able to consume a soft diet within a month post-surgery. VSP/3D printing assisted FOSCFs combined with ALTs can be performed safely to reconstruct the extensive composite tissue defects in our study, with desirable esthetic and functional results, and it is a reliable option in selecting patients with defects involving multiple tissue types. However, the benefits of this method needed more cases to validate.
A Case of Trueperella bernardiae Bacteremia due to a PICC-Associated Infection in a Paraplegic Patient
Authors: Carter Chapman, Jacob Nichols
Journal: Case Rep Infect Dis (2023)
MeSH terms: Case Reports

Trueperella bernardiae is a Gram-positive bacterium known to cause a wide variety of opportunistic infections in humans. We report a novel case of T. bernardiae bacteremia in a paraplegic patient due to a peripherally inserted central catheter- (PICC-) associated infection that was treated successfully with piperacillin/tazobactam.
Case report: a step-by-step body contouring approach in a case of young patient with CLOVES syndrome
Authors: Stefano Vaccari, Beniamino Bortoli, Camilla Maria Ester Bonzi, Arianna Balza, Edoardo Caimi, Riccardo Di Giuli, Flavio Bucci, Stefania Andreoletti, Valeriano Vinci, Francesco Klinger
Journal: Case Reports Plast Surg Hand Surg (2023)
Keywords: cloves, dermolipectomy, lipoaspiration, macrosomy
MeSH terms: Case Reports

CLOVES syndrome is a rare overgrowth disorder caused by gene mutations. This case study describes a 28-year-old woman with CLOVES syndrome who underwent multiple surgeries to achieve a positive outcome while preserving lymphovascular structures. The report underscores the importance of a multidisciplinary approach and tailored surgical interventions for managing CLOVES.
Tibial Plateau Fracture With Use of Tibia Strut and Bone Filler in a 37-Year-Old Male: A Case Report
Authors: Wayne Ngo, Germain Craddock, Alex Frangenberg, Amber Park, Niladri Basu
Journal: Cureus (2024)
Keywords: comminuted bicondylar tibial plateau fracture, orthopedics, schatzker tibial plateau classification, tibial osteotomy, tibial plateau fracture
MeSH terms: Case Reports

Tibial plateau fractures (TPFs) are orthopedic challenges with multiple injury modalities and clinical presentations. TPFs are often classified using the Schatzker classification system, which can dictate management. In our case, a 37-year-old male presented at an orthopedic specialty hospital with right knee pain after a fall from a truck ramp. X-rays and CT imaging demonstrated a comminuted bicondylar TPF in the emergency room with metaphyseal dissociation. The patient was placed in a knee immobilizer, made non-weight bearing, and scheduled for outpatient follow-up with a local orthopedic surgeon. The patient was lost to follow-up and referred to our clinic six months after the fall with the chief complaint of inability to ambulate with severe pain and instability in the knee. X-rays demonstrated a malunion of the bicondylar tibial plateau with fracture deformities of the medial femoral condyle and lateral tibial plateau. The patient's deformity was corrected with a medial opening wedge proximal tibial osteotomy with a fibula strut allograft and filled with beta-tricalcium bone filler. At the first month follow-up, the patient's pain was well controlled, fragments and the knee were appropriately aligned, and no significant soft tissue or joint effusion was appreciated on imaging. After failing nonoperative treatment, this patient with comminuted bicondylar TPF has received definitive treatment with open reduction and internal fixation. Higher rates of unacceptable results from nonoperative treatment are in line with the Schatzker series, in which operative treatment resulted in more acceptable outcomes. Because the fracture in this patient is consistent with a Schatzker VI classification with intra-articular depression, the patient should have initially been treated with an external fixator and not been sent home in a knee immobilizer. This led to a malunion that necessitated corrective surgery. Therefore, correctly classifying fracture severity is important for selecting the best treatment course and minimizing complications.
A Case of Distal Common Bile Duct Obstruction Due to a Neuroendocrine Tumor
Authors: Ramsey Rayes, Omeed Partovi, Stephanie Strohbeen, Britta L Bureau, Tamara Giorgadze, Mohamed Mostafa, Nisar Asmi
Journal: Cureus (2024)
Keywords: case report, common bile duct dilatation, common bile duct neoplasm, grade 3 neuroendocrine carcinoma, neuroendocrine tumors (nets)
MeSH terms: Case Reports

Neuroendocrine tumors (NETs) are a rare subset of malignancies in the biliary tract that may have an aggressive and initially asymptomatic course. A 93-year-old female presented with four days of abdominal pain with associated nausea, jaundice, and brown-colored urine. A CT scan revealed a soft-tissue lesion measuring 1.9 x 1.5 x 1.9 cm within the distal-most aspect of the common bile duct and papilla with marked bile duct dilatation, pancreatic duct dilatation, and multiple hepatic lesions of varying sizes. The biliary stricture was palliated with a stent via endoscopic retrograde cholangiopancreatography. Biopsies taken from the biliary mass were consistent with a well-differentiated NET: World Health Organization, Grade 3. The patient was minimally symptomatic after stenting and was discharged home. She ultimately decided not to pursue further treatment and passed away two months after the initial presentation. Currently, surgical excision is considered the main and only curative treatment for localized NETs, although chemotherapy and radiation therapy may be suitable. Early detection and treatment of these rare NETs in the biliary tree can potentially result in curative treatment.
A case report of small intestinal volvulus caused by lipomatosis of the small intestine successfully treated with enterectomy
Authors: Hao Qin, Yu Wei Zhao, Xiao Zhou Wang, Lei Jiang, Qiang Liu, Zhan Wu Li, Guang Sheng Zhao
Journal: Front Oncol (2024)
Keywords: intestinal volvulus, lipomatosis, resection, small intestinal tumor, small intestine
MeSH terms: Case Reports

Small intestinal lipomatosis is a rare condition that presents a diagnostic challenge due to the absence of identifiable clinical symptoms and limitations of small intestine examination methods. Consequently, preoperative diagnosis is difficult and only a limited number of cases have been documented in the scientific literature. Here, we report a rare case of volvulus caused by small intestinal lipomatosis. A 58-year-old female patient was tentatively diagnosed with acute ileus. The whirl sign was detected using abdominal three-dimensional enhanced computed tomography, along with marked local intestinal dilation and multiple irregular fat-like containing lesions. During surgery, abnormal dilation of the small intestine between 80 and 220 cm from the ileocecal valve was detected and the affected intestine displayed a folded and twisted configuration. Examination of the resected intestine showed that the inner wall of the diseased intestinal lumen was covered with more than 100 lipomas of different sizes, the largest of which measured ~8.0 cm in diameter. Based on clinical symptoms alone, it was difficult to identify the cause of intestinal volvulus before surgery. Complete resection of the affected small intestine and subsequent pathological analysis yielded a definitive diagnosis of small intestinal lipomatosis. While small intestinal lipomatosis is a rare condition, prognosis is favorable if diagnosed early and treated appropriately. The application of three-dimensional enhanced computed tomography imaging can aid in accurate diagnosis, while complete resection of the affected small intestine is crucial to improve patient prognosis.
Solitary bone plasmacytoma of the axis, a rare and challenging case with good outcomes
Authors: Ahmed Zendeoui, Mouadh Nefiss, Anis Bousrih, Anis Tborbi, Ramzi Bouzidi, Khelil Ezzaouia
Journal: Int J Surg Case Rep (2024)
Keywords: case report, cervical spine, plasmocytoma
MeSH terms: Case Reports

Introduction:
Plasmacytoma is a rare hematological malignancy with a more favorable prognosis than multiple myeloma. This case report focuses on a unique solitary bone plasmacytoma (SBP) at the craniovertebral junction (CVJ), managed through surgery and radiotherapy.
Case presentation:
A 50-year-old patient presented with four months of worsening neck pain and cervicobrachial neuralgia. Despite treatment and physiotherapy, symptoms persisted. Clinical examination revealed neck stiffness, with no motor or sensory deficits. Radiographs and MRI showed an infiltrating axis lesion without instability signs. A CT-guided biopsy yielded inconclusive results. To address instability and establish a diagnosis, a curettage biopsy of the C2 posterior arch was performed, followed by occipito-C4 fusion using an iliac crest graft. Histological examination confirmed SBP. Adjuvant radiotherapy and chemotherapy were administered. At four-year follow-up, there was no multiple myeloma progression, but limited neck mobility were reported, with stable fusion observed on imaging.
Discussion:
Solitary bone plasmacytoma primarily affects the axial skeleton, with rare upper cervical spine involvement. Diagnostic criteria include histological confirmation, normal bone marrow analysis, unremarkable imaging (except for the primary lesion), and absence of end-organ damage related to lymphoplasmacytic proliferative disorders. Clinical presentation is nonspecific, and MRI is valuable for soft tissue assessment. Radiotherapy is the primary treatment, with surgery reserved for specific indications.
Conclusion:
Solitary bone plasmacytoma is a rare condition with a favorable prognosis when promptly managed. This case underscores the importance of early diagnosis and treatment to prevent recurrence or multiple myeloma progression. A multidisciplinary approach, including surgery when necessary, is crucial for optimal outcomes.
Use of surgical grafting as a part of multidisciplinary treatment for a patient treated with fixed orthodontic therapy to improve treatment outcomes
Authors: Hoang Viet, Tran Hong Phuoc, Hoang Ming Tuyen, Anand Marya
Journal: Clin Case Rep (2023)
Keywords: diastema gingival grafting, multidisciplinary, surgery
MeSH terms: Case Reports

Key clinical abstract:
Multidisciplinary treatment options can help provide good clinical outcomes if these are appropriately sequenced and carried out correctly. This case exemplifies interdisciplinary involvement to ensure the patient received an improved esthetic outcome.
Abstract:
The presence of anterior diastemas may compromise the esthetics of a patient's smile, causing mental, and social trauma in many patients. After careful evaluation Periodontal, surgical, and prosthodontic treatments are sometimes required to ensure successful treatment outcomes using a multidisciplinary staged treatment approach. These approaches must be carefully planned to ensure timely treatment progress. Surgical intervention must be planned at the right point in treatment to ensure adequate healing before placement of esthetic restorations.
Complete response to disitamab vedotin in HER2-low metastatic endometrial carcinoma: a case report and review of the literature
Authors: Hu Feng, Shasha Bi, Shanshan Sun, Hongbo Yang, Haoxing Zhou, Jingjing Mao, Na Li, Fujun Yang
Journal: Front Oncol (2024)
Keywords: adcs, her2-low, rc48, complete response, endometrial cancer, recurrent metastasis
MeSH terms: Case Reports

Endometrial cancer (EC) is one of the most common gynecologic malignancies with increasing morbidity. The prognosis for patients diagnosed with early-stage EC remains favorable; however, for patients with recurrent or metastatic EC, the prognosis is poor and treatment options, until recently, are limited. Antibody drug conjugates (ADCs) represent innovative strategies in cancer treatment; however, there are less investigations regarding their efficacy in EC. This report describes an EC case with low human epidermal growth factor receptor 2 (HER2) immunohistochemistry (IHC) expression score (IHC 2+) that experienced recurrent metastasis in the abdominal and peritoneal following post-surgical chemotherapy and radiotherapy. Subsequently, the commencement of HER2-targeted ADC, disitamab vedotin (RC48; 2.5 mg/kg), administered intravenously every two weeks, was initiated. The tumor lesions shrunk markedly after three cycles of treatment and disappeared by the completion of ten cycles of therapy. The patient is still in remission at present. The current findings imply the potential efficacy of HER2-targeted ADCs for patients with HER2-low metastatic EC.
Blindness in Right Eyes after Enema: A Case of Klebsiella pneumoniae-Related Invasive Liver Abscess Syndrome with Endophthalmitis-Caused Blindness as the First Symptom
Authors: Qi Jin, Xinrui Zhang, Huifen Yang, Bo Zhao, Yubao Wang
Journal: Case Rep Med (2024)
MeSH terms: Case Reports

We report a case of Klebsiella pneumoniae invasive liver abscess syndrome (KPILAS) with endophthalmitis-caused blindness as the first symptom after enema. The patient had diabetes, and his blood glucose was poorly controlled. She developed hematuria after four enemas for cosmetic purposes and later became blind. The eye discharge was cultured, which revealed a Klebsiella pneumoniae infection. B ultrasound did not show liver lesions, but computed tomography exhibited abscesses in the right lobe of the liver. Magnetic resonance imaging of the head indicated abscesses. These confirmed the diagnosis of invasive liver abscess syndrome. The patient was given ophthalmic and systemic anti-infection treatments, and her condition was effectively controlled. Unfortunately, the diseased eye still needed to be removed. This case underlines the necessity of avoiding unnecessary risky procedures (such as enemas) in vulnerable populations, the importance of early detection of invasive liver abscess syndrome, and the advantage of computed tomography in detecting liver abscesses.