OpenMed/multicare-articles huggingface dataset:
Extensive Subcutaneous Emphysema Post-traumatic Tube Thoracostomy
Authors: Mariam Mallat, Abdallah Diab, Jerar Bleibel, Layal Olaywan
Journal: Cureus (2023)
Keywords: broncho cutaneous fistula, lung injury, subcutaneous emphysema, thoracic radiology, traumatic tube thoracostomy
MeSH terms: Case Reports

Bronchocutaneous fistula (BCF) is a pathologic communication between the bronchus and the subcutaneous tissue. Its diagnosis is made mainly by chest imaging, and bronchoscopy can help in accurately localizing the fistula. Treatment options include conservative and non-conservative approaches. We report a case of iatrogenic bronchocutaneous fistula occurring after traumatic chest tube placement in an 81-year-old man, treated efficiently with conservative management.
Torsion of a giant pedunculated liver hemangioma mimicking acute appendicitis: a case report
Authors: Feyzullah Ersoz, Ozhan Ozcan, Ahmet Burak Toros, Serdar Culcu, Hasan Bektas, Serkan Sari, Esra Pasaoglu, Soykan Arikan
Journal: World J Emerg Surg (2010)

Hemangiomas are the most common benign neoplasms affecting the liver. They occur at all ages. Most cases are asymptomatic and do not require any treatment. Rarely, hemangiomas can be pedunculated. If they undergo torsion and infarction, they become symptomatic. Herein; we report the case of a 31 year old male presenting with features of acute appendicitis: continuous right iliac fossa pain, rebound, guarding tenderness at McBurney' s point, nausea, anorexia, shifted white blood cell count and a Mantrels score of 6. At laparotomy a normal appendix was observed and a torsioned pedinculated liver hemangioma turned out to be the cause.
A case of stridor due to subglottic stenosis resulting from relapsing polychondritis in a young woman
Authors: V Gnanasoundran, K K Santhoshraj, M N Prakash
Journal: Afr J Thorac Crit Care Med (2018)
Keywords: relapsing polychondritis, respiratory emergency, stridor
MeSH terms: Case Reports

Relapsing polychondritis is a rare and severe progressive, multisystem autoimmune disease that affects cartilaginous tissues predominantly of the ear, nose, respiratory system and joints. The rarity of the disease, its unknown aetiology, the array of many possible presenting symptoms, lack of specific investigation for diagnosis and episodic nature, often cause a significant delay in diagnosis. We report a case of a young woman presenting with stridor due to subglottic stenosis of the trachea. In this case, identification of symptoms associated with the stridor facilitated the diagnosis of relapsing polychondritis and initiation of appropriate treatment.
Case report: Two cases of Poirier-Bienvenu neurodevelopmental syndrome and review of literature
Authors: Xiaolan Chen, Yunli Han, Xing Li, Shiqin Huang, Hai Yuan, Yuanhan Qin
Journal: Front Pediatr (2023)
Keywords: csnk2b gene, mosaic, poirier-bienvenu neurodevelopmental syndrome (pobinds), developmental delay, seizure, variant
MeSH terms: Case Reports

The Poirier-Bienvenu neurodevelopmental syndrome (POBINDS) is a rare disease caused by mutations in the CSNK2B gene, which is characterized by intellectual disability and early-onset epilepsy. Mosaicism has not been previously reported in CSNK2B gene. POBINDS is autosomal dominant and almost all reported cases were de novo variants. Here, we report two patients were diagnosed with POBINDS. Using Whole Exome Sequencing (WES), we detected two novel CSNK2B variants in the two unrelated individuals: c.634_635del (p.Lys212AspfsTer33) and c.142C > T (p.Gln48Ter) respectively. Both of them showed mild developmental delay with early-onset and clustered seizures. The patient with c.634_635del(p.Lys212AspfsTer33) variant was mutant mosaicism, and the proportion of alleles in peripheral blood DNA was 28%. Further, the literature of patients with a de novo mutation of the CSNK2B gene was reviewed, particularly seizure semiology and genotype-phenotype correlations.
Case Report: Refractory Listeria innocua Meningoencephalitis in a Three-Year-Old Boy
Authors: Yi Liao, Lingling Liu, Hua Zhou, Feng Fang, Xinglou Liu
Journal: Front Pediatr (2022)
Keywords: listeria innocua, blood culture, hydrocephalus, infection, meningoencephalitis
MeSH terms: Case Reports

Listeria innocua is widely distributed in the environment and food and is considered a non-pathogenic bacterium for both humans and animals. To our knowledge, only a few cases of L. innocua infection in humans and ruminants have been reported. Moreover, there has been no report on human L. innocua meningoencephalitis. Here, we report a case of severe refractory meningoencephalitis in a three-year-old boy after infection with L. innocua. The child's first symptoms were a runny nose, high fever, and rashes, which quickly progressed to unconsciousness and convulsions. The initial analysis of cerebral spinal fluid revealed remarkably elevated protein levels and increased white blood cells count. The blood culture of the patient in the early stage was positive for L. innocua. In addition, his brain imaging tests were observed dynamically, and the result showed a speedy progression from multiple intracranial abnormal signals to hydrocephalus and interstitial cerebral edema. After receiving antibiotics and symptomatic treatment for nearly 3 months, the patient's condition improved markedly. However, he still had residual complications such as hydrocephalus. Although L. innocua is considered harmless, it can still cause disease in humans, even severe meningoencephalitis, with rapid progression and poor prognosis. Early discovery, diagnosis, and treatment are necessary to elevate the survival rate and life quality of those patients. Antibiotics should be used with sufficient duration and dosage. Cephalosporins are not suitable for the treatment of L. innocua meningoencephalitis and penicillin antibiotics are preferred for children. The presentation of this case will help to expand our knowledge of Listeria infections and provide a potential candidate for pathogens causing severe childhood central nervous system infection.
Ruxolitinib improves symptoms and quality of life in a patient with systemic mastocytosis
Authors: Abdulraheem Yacoub, Lindsey Prochaska
Journal: Biomark Res (2016)
Keywords: mastocytosis, quality of life, ruxolitinib, systemic mastocytosis
MeSH terms: Case Reports

Background:
Systemic mastocytosis is a clonal myeloproliferative neoplasm associated with constitutional symptoms from mast cell mediated chemical and cytokine release. According to the literature, Ruxolitinib, a JAK1/JAK2 inhibitor, has been shown to reduce symptoms related to proinflammatory cytokine release in other myeloproliferative neoplasms.
Case presentation:
Here we present a case using Ruxolitinib for disabling constitutional symptoms despite complete bone marrow response in a patient with aggressive systemic mastocytosis. Assessment tools used to monitor symptoms in previously published Ruxolitinib trials were adopted to track symptom improvement and quality of life.
Conclusions:
Ruxolitinib significantly improved symptoms and quality of life in our patient with systemic mastocytosis.
An unusual case of abdominal wall bleeding after renal allograft biopsy
Authors: C G Koshy, B R Chacko, S Babu, G Basu, D Selvaraj, G T John
Journal: Indian J Nephrol (2011)
Keywords: abdominal wall bleeding, angiography, pseudoaneurysm, renal allograft biopsy complication
MeSH terms: Case Reports

We report an unusual case of a enlarging anterior abdominal wall hematoma after percutaneous biopsy of a renal allograft. Angiography-directed embolization of the vessels filling the pseudoaneurysm was done and followed up with surgical exploration of the hematoma. In order to avoid this complication, Color Doppler evaluation of the overlying abdominal wall is suggested to look for significant vessels before the biopsy procedure.
Yokenella regensburgei Septicemia in a Chinese Farmer Immunosuppressed by HIV: A Case Report and Literature Review
Authors: Xiangbo Chi, Min Liu, Yaokai Chen
Journal: Case Rep Infect Dis (2017)
MeSH terms: Case Reports

Yokenella regensburgei is a member in the family Enterobacteriaceae and a few cases have been reported in immunocompromised hosts. Herein, we described a case of septicemia in a human immunodeficiency virus (HIV) infected patient in South West China, which is the first reported case of Y. regensburgei infection in HIV-infected populations. We then reviewed the literature on all the reported cases of Y. regensburgei infection worldwide and presented some common features of them. Our case report and literature review will help increase the knowledge of the bacterium Y. regensburgei and its clinical implications.
Utilization of Platelet-Rich Plasma for a Fistula With Subcutaneous Cavity Following Septic Bursitis: A Case Report
Authors: Satoshi Kushida, Natsuko Kakudo, Naoki Morimoto, Yudai Mori, Kenji Kusumoto
Journal: Eplasty (2015)
Keywords: fistula, platelet-rich plasma, septic bursitis, subcutaneous cavity, wound healing
MeSH terms: Case Reports

In platelet-rich plasma (PRP) therapy, various growth factors and cytokines released the α-granules contained in platelets after activation can potentially enhance wound healing by delivering. We report a patient in whom treatment with PRP, prepared using a syringe-centrifugation-system PRP kit (KYOCERA Medical PRP Kit), for a fistula following bursitis of the lateral malleolus, which could not be healed with conventional wound therapy, led to successful healing. A 58-year-old man was on dialysis for type II diabetes and chronic renal failure. In the left lateral malleolus, septic bursitis developed, leading to a refractory fistula with a subcutaneous cavity measuring 4 × 3 cm, which persisted for more than 2 months. Platelet-rich plasma was prepared using the KYOCERA Medical PRP Kit (KYOCERA Medical Corporation, Osaka, Japan) and infused into the cavity twice to close it. After this procedure, the cavity size reduced, but the orifice and subcutaneous cavity were not closed. Therefore, additional PRP therapy was conducted after 10 weeks of the first PRP session. Complete closure was achieved 13 weeks after the first PRP therapy. In the present case, PRP was prepared using the KYOCERA Medical PRP Kit, and wound healing of a fistula with subcutaneous cavity following bursitis of the lateral malleolus was successfully cured. The KYOCERA Medical PRP Kit was useful, because PRP could be prepared simply and inexpensively using the syringe-centrifugation system.
Metastases to Both Parotid Glands Six and Twelve Years after Resection of Renal Cell Carcinoma
Authors: Achim M Franzen, Shirrell Glitzky, Ashok Moganti, Frank Lippek, Annekatrin Coordes
Journal: Case Rep Med (2018)
MeSH terms: Case Reports

Metastases of renal cell carcinoma (RCC) involving the parotid gland are very rare. We present to our knowledge the first case of a 74-year-old woman with metastases of an RCC which affected both parotid glands six and twelve years following curative therapy.
Clinical manifestation and risk factors of tuberculosis infection in Malaysia: case study of a community clinic
Authors: Rohan Shanmuganathan, Indra Devi Subramaniam
Journal: Glob J Health Sci (2015)
MeSH terms: Community Health Centers, Tuberculosis / epidemiology, Research Support, Non-U.S. Gov't, Adult, Age Factors, Comorbidity, Diabetes Mellitus / epidemiology, Female, HIV Infections, Humans, Malaysia / epidemiology, Male, Middle Aged, Qualitative Research, Risk Factors, Young Adult

Introduction:
The main aim of this study was to describe the clinical manifestation of tuberculosis infection cases in Malaysia and to determine the individual risk factors for their occurrence.
Methodology:
The study adopted a quantitative research approach with use of descriptive statistical approach. The study setting was a community clinic which treats walk in patients who are mainly living and working in the surrounding areas. The study was conducted for a period of one year. All tuberculosis patients who sought treatment in the clinic during the time were included in this study. The total number of cases was 40. Data was collected from the medical records of the tuberculosis patients. The risk factors selected for investigation were demographic characteristics of age and sex, personal habits such as smoking, drug use and alcohol and presence of diseases such as human immunodeficiency virus positive (HIV+), diabetes mellitus, cancer, cyanotic heart disease, renal failure and steroid use.
Results:
Patients in the age group ranging from 41 to 50 years had the highest incidence of the infection. Smoking appears to be the most important risk factor for contracting followed by drug abuse, HIV+ infection and diabetes mellitus.
Conclusions:
People with diseases such as diabetes mellitus and HIV that are high risk factors for TB should be screened for TB so that early detection and intervention is possible. Educational programs should be carried out to create awareness among the at risk groups.
COVID-19 Transmission Within a Family Cluster in Yancheng, China
Authors: Hongming Zhang, Runzhe Chen, Jibei Chen, Baoan Chen
Journal: Front Med (Lausanne) (2020)
Keywords: covid-19, sars-cov-2, asymptomatic, family cluster, intimate contact, transmission
MeSH terms: Case Reports

We report the clinical features of novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in a family setting of 13 people with person-to-person transmission in Yancheng, Jiangsu Province, China.
Best management modality of trichobezoar: A case report
Authors: Emad M Al-Osail, N Y Zakary, Yasir Abdelhadi
Journal: Int J Surg Case Rep (2018)
Keywords: case report, endoscopy, laparotomy, psychiatric, trichobezoar

Introduction:
Trichobezoar is a rare condition, usually diagnosed in children and young female especially with psychiatric illness. Diagnosis of trichbezoar is usually dependent on the disease history, examination, diagnostic modality including CT scan. Generally this condition can be treated by endoscopy, laparoscopy or laparotomy. Here, we have presented a rare case of trichobezoar which has failed to be treated endoscopically but was eventually treated successfully by laparotomy.
Case report:
A 17 years old girl was presented with the initial complaint of epigastric pain for about 9 months duration with symptoms including vomiting and weight loss. Clinical examination showed tenderness and hard mass over epigastric area and it was extending towards the right hypochondrial area. CT scan results also showed that the stomach was filled with large intra-luminal abnormal mass like contents with mottled air pattern extended to fill the pylorus and first part of the duodenum. These findings were the proofs for possible trichobezoar. Endoscopic surgery failed significantly and hence laparotomy was performed, as a result, trichbezoar was removed successfully.
Discussion:
Trichobezoar can be treated by using endoscopy for removal of hair, laparoscopy or Laparotomy. Laparotomy had 100% successful rate while 5% for endoscopy and 75% for laparoscopy.
Conclusion:
Laparotomy is the best treatment method for trichobezoare. Psychiatric management should be done for any patient with trichotillomania to avoid trichobezoar.
Case Report: MIS-C Temporarily Associated With COVID-19 Complicated by Reye's Syndrome
Authors: Fabrício Silva Pessoa, Eliza Maria da Costa Brito Lacerda, Valdênia Costa Gonçalves, Barbara Neiva Tanaka
Journal: Front Pediatr (2021)
Keywords: covid-19, covid-19 pandemic, reye syndrome, sars-cov-2 (covid-19), multisystem inflammatory syndrome in children
MeSH terms: Case Reports

We describe a 7-year-old child with multisystemic inflammatory syndrome that was temporarily associated with the novel coronavirus disease which evolved into serious illness, with coronary aneurysm, using human immunoglobulin and acetylsalicylic acid, in which clinical manifestations including hepatitis, convulsions, and coma were aggravated with Reye's syndrome. To date, there has been no report of the association of multisystemic inflammatory syndrome that is temporarily associated with the novel coronavirus disease and Reye's syndrome.
A Review Leveraging a Rare and Unusual Case of Basal Cell Carcinoma of the Prostate
Authors: Lin He, Christopher Metter, Vitaly Margulis, Payal Kapur
Journal: Case Rep Pathol (2021)
MeSH terms: Case Reports

Basal cell carcinoma (BCC) is a rare nonacinar variant of prostatic carcinoma. In spite of prostatic acinar adenocarcinoma being one of the most common carcinomas in prostate, <100 prostatic BCC cases have been reported to date. Adenoid cystic/cribriform histology has been described in varying proportions to occur in prostatic BCC and is reported to be associated with aggressive behavior and high risk of metastasis. Herein, we present a case of prostatic BCC with adenoid cystic morphology, comprehensively describe its immunohistochemical and MYB/MYBL1 gene rearrangement findings, discuss its differential diagnosis, and review the literature of this rare entity.
Resistance to thyroid hormone beta coexisting with papillary thyroid carcinoma-two case reports of a thyroid hormone receptor beta gene mutation and a literature review
Authors: Yingxin Fang, Tingting Liu, Huimin Hou, Zhihong Wang, Zhongyan Shan, Yanli Cao, Xiaochun Teng
Journal: Front Genet (2022)
Keywords: thrb gene mutation, tsh suppression therapy, papillary thyroid carcinoma, resistance to thyroid hormone, thyroid hormone receptor
MeSH terms: Case Reports

Resistance to thyroid hormone beta (RTHβ) is an autosomal dominant hereditary disorder that is difficult to diagnose because of its rarity and variable clinical features, which are caused by mutations in the thyroid hormone receptor beta (THRB) gene. Recent studies have indicated a close association between THRB mutations and human cancers, but the mechanistic role of THRB mutations in carcinogenesis is unknown. Herein, we report two cases of RTHβ coexisting with papillary thyroid carcinoma (PTC) and their follow-up results. Two female patients presented with elevated serum thyroid hormone levels and nonsuppressed thyrotropin (TSH). Genetic analysis showed that each patient had a THRB gene mutation (p.P453T and p. R320H). Based on the results of ultrasound-guided fine-needle aspiration biopsy, the thyroid nodules were suspected to be PTC. Intraoperative pathology confirmed that the two patients had PTC with multifocal carcinoma of both lobes. One patient underwent total thyroidectomy and central lymph node dissection, and the other underwent total thyroidectomy alone. Following surgery, large doses of levothyroxine were administered to suppress TSH levels and prevent recurrent or persistent disease. However, it is difficult to continually suppress TSH levels below the upper limit of the normal range. To date, the two patients have experienced no recurrence of PTC on ultrasound.
Case report: Coexistence of Labbe vein thrombosis and autoimmune encephalitis with two different antibodies
Authors: Lu Yang, Dongqing Zhang
Journal: Front Neurol (2023)
Keywords: gababr, mri, nmdar, autoimmune encephalitis (ae), child, venous thrombosis
MeSH terms: Case Reports

Anti-NMDA receptor encephalitis is an autoimmune encephalitis well- known to pediatric neurologists. The characteristic combination of symptoms and detection of NMDA receptor antibody can confirm the diagnosis. Most children respond well to immunosuppressive therapy. Anti-GABAB receptor encephalitis usually occurs in adult patients. Most patients present clinically with symptoms of limbic encephalitis. Cases in pediatric patients are rare. Cerebral venous thrombosis also has a very low incidence in children without underlying diseases. Patients usually present with headaches, convulsions, and focal deficits. Anticoagulants are the first choice treatment. We report a boy initially diagnosed with Labbe vein thrombosis and later tested positive for both NMDA and GABAB receptors. Anticoagulants did not relieve the boy's symptoms, and immunosuppressive therapy achieved good results. The antibody titers were significantly reduced or even turned negative. Although the Labbe vein was not recanalized at four months follow-up, the brain lesion was significantly absorbed. We learn from this case that a child can be inflicted with cerebral venous thrombosis and autoimmune encephalitis simultaneously. Child patients respond well to treatment.
Asymptomatic Coccidioidal Meningitis Relapse: A Demon in Disguise
Authors: Lovedip Kooner, Arash Heidari, Royce Johnson
Journal: J Investig Med High Impact Case Rep (2023)
Keywords: coccidioidal meningitis, coccidioidal meningitis relapse, coccidioidomycosis, meningitis, meningitis relapse, valley fever
MeSH terms: Coccidioidomycosis / complications, Coccidioidomycosis / diagnosis, Coccidioidomycosis / drug therapy, Meningitis / diagnosis, Meningitis, Fungal / diagnosis, Meningitis, Fungal / drug therapy, Case Reports, Coccidioides, Humans, Male, Middle Aged, Recurrence

Coccidioides spp is a soil-dwelling, dimorphic fungus that causes coccidioidomycosis. It is endemic to the western hemisphere. Although primarily a respiratory disease, it can also cause a myriad of clinical manifestations, from asymptomatic disease to meningitis. In fact, Coccidioides species is probably the most common etiologic agent of long-term meningitis in California and Arizona. Early diagnosis and treatment are critical to avoid fatal complications. With treatment, the cerebral spinal fluid analysis may return to normal. Relapse of coccidioidal meningitis is usually suspected with recurrence of meningitis symptoms. The patient is a 53-year-old man with a 2-decade history of coccidioidal meningitis who was diagnosed with an asymptomatic relapse of coccidioidal meningitis.
Recurrent Testicular Torsion of a Fixed Testis
Authors: Ibrahim Alnadhari, Ausama Abdulmuhsin, Omar Ali, Ahmad Shamsodini, Morshed Salah, Osama Abdeljaleel
Journal: Case Rep Urol (2019)
MeSH terms: Case Reports

Recurrent testicular torsion after previous orchiopexy is rare and needs high index of suspension to avoid misdiagnosis and delayed management. This case showed that this diagnosis can occur even when the testis is still fixed to the scrotal wall. A 31-year-old male who had previous testicular fixation for testicular torsion with a single stitch to the lower pole before 6 years presented with recurrent testicular torsion and missed diagnosis. This case confirm that recurrent testicular torsion after previous fixation should be included in the differential diagnosis of acute scrotum and emphasis on the testicular fixation with nonabsorbable suture in at least two points to prevent recurrent torsion.
Angioedema Secondary to IV Tissue Plasminogen Activator Administration for Treatment of Acute Ischemic Stroke
Authors: Benjamin Chaucer, Dustin Whelan, Christopher Veys, Manas Upadhyaya
Journal: Case Rep Crit Care (2018)
MeSH terms: Case Reports

Background:
IV tissue plasminogen activator (tPA) is the treatment of choice for ischemic strokes that present within the treatment window. In the majority of patients, this offers an effective and often life-prolonging treatment in the acute setting. In a rare set of patients treated with IV tPA, side effects can be seen. One rare and potentially dangerous side effect is angioedema.
Case report:
We present the case of a patient treated for ischemic stroke who developed angioedema and discuss the etiology and risk factors for this rare, but dangerous side effect.
Conclusion:
Given the frequent and widespread use of tPA, awareness of the rare life-threatening side effects is paramount. This is of particular importance for practitioners in the acute care setting.