OpenMed/multicare-articles huggingface dataset:
A new technique for trans-perirectal iodine-125 seed implantation in prostatic cancer guided by CT and 3D printed template: Two case reports
Authors: Xuemin Di, Hongtao Zhang, Xiaoli Liu, Jinxin Zhao, Zhen Gao, Huimin Yu, Xiaohua Su, Yansong Liang, Juan Wang
Journal: Front Oncol (2022)
Keywords: 3d-printed template, ct guidance, brachytherapy, iodine-125 seed implantation, low-dose-rate brachytherapy, prostate cancer
MeSH terms: Case Reports

Low-dose-rate prostate brachytherapy with permanent iodine-125 is an important curative treatment for low-risk prostate cancer, and it has been demonstrated that brachytherapy with permanent seeds is an effective treatment. However, differences in prostate volume, spatial location, and gland deformation between images obtained in the pre-planning phase and those obtained during the implantation procedure affect accurate delivery of the pre-planned dose. Furthermore, the complicated procedure could be a burden to elderly patients, for example, the risks associated with general anesthesia. In addition, ultrasound images are not as clear as computed tomography (CT) images with regard to identifying the location of seeds. Therefore, a new method for guidance during the procedure is urgently needed. Here, we have described a new method for precise trans-perirectal insertion of radioactive iodine-125 seeds in patients with prostate cancer under the guidance of CT and a 3D-printed template. These are some of the advantages of this technique over the standard procedure for seed implantation in the prostate: It requires only local anesthesia, the pre-planning phase can be completed before the procedure, and the operation time is considerably shorter. This report describes trans-pararectal iodine-125 seed brachytherapy for prostate cancer under local anesthesia and the guidance of a 3D printed template in two elderly patients. The dose parameters determined in the preoperative planning phase were verified postoperatively and found to be consistent. Further, the procedure was completely successfully with no major complications in both cases, and the patients' prostate-specific antigen levels were normal at the most recent follow-up conducted 50 months after the procedure. Therefore, this technique seems promising for prostate cancer brachytherapy, and its application needs to be researched and extended further in the future.
Another de novo mutation in the SOD1 gene: the first Turkish patient with SOD1-His47Arg, a case report
Authors: Elif Bayraktar, Vildan Çiftçi, Hilmi Uysal, A Nazlı Başak
Journal: Front Genet (2023)
Keywords: his47arg, sod1, de novo mutation, fals, sals
MeSH terms: Case Reports

Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease of motor neurons. Most ALS cases are considered sporadic due to the presence of a combination of environmental and complex genetic risk factors, while approximately 10% of cases have a family history. Pathogenic variants in the SOD1 gene are the second most frequent causative factor of genetics-based ALS worldwide, after C9ORF72 hexanucleotide repeat expansion. The De novo occurrence of pathogenic mutations in ALS-associated genes and its effect on disease progression have been studied previously, especially in the FUS gene. Recent studies have shown that a very small portion of SOD1 cases occurred de novo. Here, we present the first de novo case of the SOD1 His47Arg mutation in a young female patient with mild symptoms and, currently, a slow progression for 7 years.
A case of sepsis-induced cardiomyopathy successfully treated with venoarterial extracorporeal membrane oxygenation
Authors: Keigo Sato, Akihiro Naito, Taichi Shiratori, Masahiro Yamamoto, Kenichi Shimane, Manabu Mikami, Mariko Senda, Haruki Kume, Motofumi Suzuki
Journal: IJU Case Rep (2022)
Keywords: cardiomyopathy, echocardiography, left ventricular ejection fraction, sepsis, urolithiasis, venoarterial extracorporeal membrane oxygenation
MeSH terms: Case Reports

Introduction:
Sepsis with concomitant acute pyelonephritis, secondary to urolithiasis, is common. We report a case of sepsis-induced cardiomyopathy with acute pyelonephritis, successfully managed with venoarterial extracorporeal membrane oxygenation.
Case presentation:
A 64-year-old woman presented with fever and disturbed consciousness. Abdominal computed tomography revealed right hydronephrosis with ipsilateral ureteral stone. Despite ureteral stent placement and antibiotic treatment, her hemodynamics worsened. She was diagnosed with sepsis-induced cardiomyopathy and underwent venoarterial extracorporeal membrane oxygenation. Her hemodynamics improved rapidly; venoarterial extracorporeal membrane oxygenation was withdrawn on postoperative day-3. She was discharged from our hospital after sufficient antibiotic treatment.
Conclusion:
Venoarterial extracorporeal membrane oxygenation may be initiated in patients with sepsis-induced cardiomyopathy. Evaluation of left ventricular ejection fraction via echocardiography is important to determine the indication for venoarterial extracorporeal membrane oxygenation.
Pulmonary Langerhans cell histiocytosis with thyroid involvement manifesting as recurrent bilateral pneumothorax and tension bullae in a 3-year-old child
Authors: Satoshi Yokoyama, Tatsuo Nakaoka, Daisuke Fukao, Koji Yokoyama, Shigeto Hara, Keigo Hamahata, Akira Yoshida
Journal: Int J Surg Case Rep (2019)
Keywords: pneumothorax, positive pressure ventilation, pulmonary langerhans cell histiocytosis, tension bullae

Introduction:
Pulmonary Langerhans cell histiocytosis (PLCH) is a well known entity in adults but is exceedingly rare in children. The main complication of PLCH is the occurrence of pneumothorax (PTX) and tension bullae with subsequent recurrence and persistence despite conservative management.
Case presentation:
A 3-year-old child was diagnosed with PLCH with thyroid involvement. Chemotherapy was immediately initiated and continued with chest tube drainage for repeated bilateral PTX. Tension bullae developed in the right lung 1 month after initiating treatment. Emergency resection of the bullae and ligation of pulmonary cysts were performed. On the tenth postoperative day, she developed a tension bulla in the left lung. Emergency thoracotomy was performed. On the tenth postoperative day, chest X-ray and CT suggested return of the right bulla and mediastinal shift, and reoperation was performed. Repeated lung biopsy showed no sign of active LCH. Although her condition improved after the operation, subsequent repeated PTXs occurred and were difficult to treat. She was discharged home after four months. Currently, she is receiving maintenance therapy as an outpatient. During the 12-month follow-up, the pulmonary lesions also showed a tendency for improvement.
Discussion:
Although it is difficult to treat recurrent PTX and tension bullae in advanced PLCH, continuous treatment of the primary disease (LCH) and the complications of pulmonary lesions can improve prognosis.
Conclusion:
Treatment of PLCH accompanied by recurrent PTX and tension bullae is challenging. The condition can be resolved by treating the primary disease in parallel with combined modality treatment, including surgical operation for complications.
An 18-year-old patient with type 1 diabetes undergoing surgery
Authors: Massimo Pietropaolo
Journal: PLoS Med (2005)
MeSH terms: Diabetes Mellitus, Type 1 / complications, Elective Surgical Procedures, Knee Injuries / surgery, Preoperative Care, Case Reports, Adolescent, Diet, Humans, Hypoglycemic Agents / administration & dosage, Hypoglycemic Agents / therapeutic use, Insulin / administration & dosage, Insulin / therapeutic use, Male, Orthopedic Procedures / methods, Hypoglycemic Agents, Insulin

A young patient with type 1 diabetes needs an elective operation under general anesthesia. How will you manage his diabetes before, during, and after the surgery?
Stone in the distal jejunum presenting as small bowel obstruction: A case report
Authors: Nafeesah Fatimah, Abubaker Shafiq Ahmed, Muhammad Umar Warraich, Usman Ismat Butt, Qamar Ashfaq Ahmad, Mahmood Ayyaz
Journal: Int J Surg Case Rep (2018)
Keywords: fistula repair, gallstones, intestinal obstruction

Introduction:
Gallstone ileus is a rare presentation of cholelithiasis accounting for around 4% of cases of small bowel obstruction under 65 years of age but rises to 25% in those more than 65 years of age. Most gall stones, if impact in the bowel, are seen to lodge at the ileocecal valve as this is the most narrow part of the bowel.
Presentation of case:
We present a case of small intestinal obstruction because of a gallstone stuck in the distal jejunum. Patient was explored and one-stage surgery was done i.e. cholecystectomy, enterotomy and stone retrieval, and fistula repair. Our patient had uneventful postoperative recovery and was discharged after a week.
Discussion:
Gallstone ileus is a rare entity presenting a significant diagnostic challenge to surgeons due to lack of specific findings. Moreover, the surgical management options to be adopted are diverse and depend upon the condition of the patient. Stable patients can be managed with two-stage procedures i.e. enterotomy and stone retrieval earlier with cholecystectomy in an elective setting. Our patient was managed with one-stage procedure i.e. cholecystectomy was done in the same setting and our patient did well.
Conclusion:
Gallstone ileus needs to be kept in the differential diagnosis list of intestinal obstruction in middle aged patients even in the absence of history of gallstones as this may be the first presentation of gallstone disease.
A rare combination of tibial artery aneurysm and traumatic arteriovenous fistula: a case report
Authors: Chrysanthi Papageorgopoulou, Konstantinos Nikolakopoulos, Ioannis Ntouvas, Spyros Papadoulas, Neoklis Kritikos
Journal: Pan Afr Med J (2022)
Keywords: tibial artery aneurysm, arteriovenous fistula, case report, endovascular treatment, trauma
MeSH terms: Aneurysm / complications, Aneurysm / surgery, Arteriovenous Fistula / etiology, Arteriovenous Fistula / surgery, Vascular System Injuries / surgery, Case Reports, Humans, Male, Middle Aged, Stents / adverse effects, Tibial Arteries

Aneurysms of the tibial arteries are rare, and they most commonly occur due to trauma of the lower extremities. Acquired arteriovenous fistulas of the tibial arteries are a recognized complication of trauma of the lower extremity and they are related to the mechanism of the injury. Although the natural history of stable arteriovenous fistula is relatively benign, the aneurysms of the tibial arteries should be repaired with autologous vein bypass grafts, if there is distal ischemia. Endovascular repair has been reported as an effective alternative treatment for traumatic tibial artery aneurysms. The case of a 60-year-old male with the rare combination of a tibial artery aneurysm and traumatic arteriovenous fistula of the left lower extremity is reported in view of its rarity and the modern holistic endovascular approach used for treatment. A covered stent graft in the anterior tibial artery was used for the treatment of both the aneurysm and the arteriovenous fistula. The patient was discharged under dual antiplatelet treatment for three months, continued by clopidogrel as monotherapy. At the six-month follow-up, the patient has restored palpable peripheral pulses and no sign of recurrence or complication was recognized. A total endovascular approach can be an effective treatment for these complicated traumatic aneurysms.
An 18-Year-Old Female Experiences Unilateral Vocal Cord Paralysis during Mild COVID-19 Infection
Authors: John M Coggins, Charisse Wright, Michael P Underbrink
Journal: Case Rep Otolaryngol (2022)
MeSH terms: Case Reports

The COVID-19 pandemic has shown with certainty that SARS-CoV-2 can cause a variety of clinical findings, with some of the most notable being lasting chemosensory changes. Severe infections with SARS-CoV-2 can also lead to a variety of complications. For example, vocal cord paralysis can be caused by trauma sustained during intubation, which is a necessary procedure for many severe cases. Rarely, SARS-CoV-2 related vocal cord paralysis has occurred outside the context of intubation. These cases contribute to an emerging assortment of evidence supporting the neuropathic capacity of SARS-CoV-2. This report documents a case of COVID-19 related vocal cord paralysis in an 18-year-old female. The patient had a significant history of muscle tension dysphonia, chronic laryngitis, and vocal cord nodules. The patient developed vocal cord paralysis concurrently with the onset of mild viral symptoms and was never intubated or hospitalized. Based on the onset of symptoms and other causes being excluded with CT, a diagnosis of COVID-19-related vocal cord paralysis was performed.
Endovascular Management of Right Subclavian Artery Pseudoaneurysm due to War Injury in Adolescent Patient
Authors: Onur Saydam, Deniz Şerefli, Mehmet Atay, Cengiz Sert
Journal: Case Rep Vasc Med (2017)
MeSH terms: Case Reports

Today there is a widespread use of endovascular treatment (EVT) for traumatic vascular injuries in adults, but there is lack of evidence of its use in adolescent patients with vascular injuries. With this case, we present successful EVT of 14-year-old adolescent with a right subclavian artery pseudoaneurysm (SAP) due to war injury. SAP was successfully excluded with deployment of 6 × 50 mm flexible, self-expanding covered nitinol stent graft (The GORE® VIABAHN® Endoprosthesis (W.L. Gore & Associates, Flagstaff, AZ)). Patient was discharged from hospital 2 days after the procedure with dual antiplatelet therapy (clopidogrel and aspirin). 3 months after discharge control DUS showed patent stent graft without any residual lesions. As a result, EVT is an alternative approach to treatment of SAP. It is safe, effective, and less invasive therapy for SAP in adults as well as in adolescents. We aim to contribute to the literature with this first case report.
Regression of metastatic melanoma in a patient by antibody targeting of cancer stem cells
Authors: Max Schlaak, Patrick Schmidt, Christopher Bangard, Peter Kurschat, Cornelia Mauch, Hinrich Abken
Journal: Oncotarget (2012)
MeSH terms: Antibodies, Monoclonal, Murine-Derived / therapeutic use, Melanoma / therapy, Neoplastic Stem Cells / immunology, Skin Neoplasms / therapy, Case Reports, Research Support, Non-U.S. Gov't, Aged, Antibodies / administration & dosage, Antibodies / therapeutic use, Antibodies, Monoclonal, Murine-Derived / administration & dosage, Antineoplastic Combined Chemotherapy Protocols / therapeutic use, Dacarbazine / administration & dosage, Foot, Humans, Male, Melanoma / pathology, Molecular Targeted Therapy, Neoplastic Stem Cells / drug effects, Neoplastic Stem Cells / pathology, Remission Induction, Rituximab, Skin Neoplasms / pathology, Tumor Burden, Antibodies, Antibodies, Monoclonal, Murine-Derived, Rituximab, Dacarbazine

Current therapeutic regimens attempt to eliminate all malignant cells of a melanoma lesion; pre-clinical data, however, indicate that melanoma, once established, is maintained by a minor, non-random subset of cancer cells which are characterized by CD20 expression. We asked to eliminate those cells in a progressing, chemotherapy-refractory metastatic melanoma patient by lesional injections of the anti-CD20 therapeutic antibody rituximab and concomitant low dose systemic dacarbazine treatment. Although the frequencies of CD20+ melanoma cells within the tumor lesions were initially about 2% and the bulk of tumor cells did not express CD20, rituximab treatment produced lasting remission of treated tumor lesions in the long-term. Remission was accompanied by a decline of the melanoma serum marker S-100 to physiological levels. Detailed in-depth-analyses revealed a switch of serum cytokines from a T helper-2 to a pro-inflammatory T helper-1 cell profile. Apart from B cell elimination and decline in gammaglobulin levels, no grade 3/4 toxicity related to treatment was observed. Data provide the first clinical evidence that targeting the minor subset of CD20+ "melanoma sustaining cells" produces regression of chemotherapy-refractory melanoma and highlight the potency of selective cancer cell targeting in the treatment of melanoma.
Laparoscopic management of gastric liposarcoma: A case report and review of the literature
Authors: Hector W Cure, Daniel Gómez, Mauricio Pedraza, Hector Cure Bulicie, Luis Felipe Cabrera, Luis Paolo Gil Gil, David Acevedo, Laura Cabrera, Valery Moreno, Andrés Mendoza
Journal: Int J Surg Case Rep (2020)
Keywords: case report, diagnostic imaging, endoscopy, liposarcoma, surgery
MeSH terms: Case Reports

Introduction:
Liposarcoma is one of the most common mesenchymal neoplasms in adults. Predominant locations are the retroperitoneum and limbs, it rarely occurs in the gastrointestinal tract. Gastric liposarcoma is extremely rare, with fewer than 30 cases reported around the world.
Presentation of case:
Here we present the case of a 70-year-old female patient who was diagnosed with gastric liposarcoma and managed with laparoscopic surgical resection. The patient is currently being followed up and is alive without recurrence 12 months after the operation.
Discussion:
Gastric liposarcoma approach requires proper diagnosis with computed tomography and endoscopy, in order to develop an adequate surgical plan. Laparoscopic en-bloc resection and gastrointestinal reconstruction is the ideal management in this type of patient.
Conclusion:
Gastric liposarcoma is an extremely rare entity, his management consists of wide en-bloc resection with a gastrointestinal reconstruction.
Bipolar affective disorder and migraine
Authors: Birk Engmann
Journal: Case Rep Med (2012)
MeSH terms: Case Reports

This paper consists of a case history and an overview of the relationship, aetiology, and treatment of comorbid bipolar disorder migraine patients. A MEDLINE literature search was used. Terms for the search were bipolar disorder bipolar depression, mania, migraine, mood stabilizer. Bipolar disorder and migraine cooccur at a relatively high rate. Bipolar II patients seem to have a higher risk of comorbid migraine than bipolar I patients have. The literature on the common roots of migraine and bipolar disorder, including both genetic and neuropathological approaches, is broadly discussed. Moreover, bipolar disorder and migraine are often combined with a variety of other affective disorders, and, furthermore, behavioural factors also play a role in the origin and course of the diseases. Approach to treatment options is also difficult. Several papers point out possible remedies, for example, valproate, topiramate, which acts on both diseases, but no first-choice treatments have been agreed upon yet.
Case report: Cryoablation as a novel bridging strategy prior to CAR-T cell therapy for B cell malignancies with bulky disease
Authors: Xiaomin Zhang, Jinming Wu, Liangliang Qiao, Lixuan Chen, Chaolin Chen, Hui Zhang, Rongcheng Luo, Yang Xiao
Journal: Front Oncol (2023)
Keywords: car-t cell therapy, bridging therapy, cryoablation, multiple myeloma, primary cutaneous diffuse large b-cell lymphoma leg type
MeSH terms: Case Reports

Chimeric antigen receptor (CAR) T-cell therapy has emerged as a powerful immunotherapy in relapsed/refractory (R/R) hematological malignancies, especially in R/R B-cell acute lymphocytic leukemia (B-ALL), non-Hodgkin lymphoma (NHL), and multiple myeloma (MM). To prevent disease progression and reduce tumor burden during CAR-T cell manufacturing, bridging therapies prior to CAR-T cell infusion are crucial. At present, it has been demonstrated that targeted therapy, radiotherapy and autologous stem cell transplantation (ASCT) could serve as effective bridging strategies. However, whether cryoablation could serve as a novel bridging strategy is unknown. In this paper, we report 2 cases of R/R B cell malignancies with bulky disease that were successfully treated with a combination of cryoablation and CAR-T cell therapy. Patient 1 was a 65-year-old female who was diagnosed with R/R MM with extramedullary disease (EMD). She was enrolled in the anti-BCMA CAR-T cell clinical trial. Patient 2 was a 70-year-old man who presented with a subcutaneous mass in the right anterior thigh and was diagnosed with primary cutaneous diffuse large B cell lymphoma, leg type (PCLBCL-LT) 1 year ago. He failed multiline chemotherapies as well as radiotherapy. Thus, he requested anti-CD19 CAR-T cell therapy. Unfortunately, they all experienced local progression during CAR-T cell manufacturing. To rapidly achieve local tumor control and reduce tumor burden, they both received cryoablation as a bridging therapy. Patient 1 achieved a very good partial response (VGPR) 1 month after CAR-T cell infusion, and patient 2 achieved a partial response (PR) 1 month after CAR-T cell infusion. In addition, adverse effects were tolerable and manageable. Our study demonstrated the favorable safety and efficacy of combination therapy with cryoablation and CAR-T cell therapy for the first time, and it also indicates that cryoablation could serve as a novel therapeutic strategy for local tumor control in B cell malignancies.
Lymphangitis carcinomatosa as an unusual presentation of renal cell carcinoma: a case report
Authors: James E Kirk, Maruti Kumaran
Journal: J Med Case Rep (2008)

Introduction:
Renal cell carcinoma is a common adult malignancy that can present incidentally or with a multitude of clinical symptoms and signs. Metastatic spread is frequent, occurring via haematogenous and lymphatic routes, although it does not typically present with lymphangitis carcinomatosa.
Case presentation:
We describe a patient who presented with cough and increasing dyspnoea. Initial chest x-ray and computed tomography were consistent with lymphangitis carcinomatosa that proved secondary to underlying renal cell carcinoma.
Conclusion:
Lymphangitis carcinomatosa occurs with many different primary tumours and can rarely be the presenting feature of renal cell carcinoma. Underlying renal cell carcinoma should be considered in the differential diagnosis of lymphangitis carcinomatosa and excluded with subsequent investigations.
A case of airway aluminosis with likely secondary pleuroparenchymal fibroelastosis
Authors: Yuki Yabuuchi, Hitomi Goto, Mizu Nonaka, Hiroaki Tachi, Tatsuya Akiyama, Naoki Arai, Hiroaki Ishikawa, Kentaro Hyodo, Kenji Nemoto, Yukiko Miura, Isano Hase, Shuji Oh-Ishi, Kenji Hayashihara, Takefumi Saito, Tatsuya Chonan
Journal: Multidiscip Respir Med (2019)
Keywords: elemental analysis, interstitial pneumonia, occupational lung disease, trans-bronchial lung biopsy
MeSH terms: Case Reports

Background:
Excessive inhalation of aluminium powder occasionally results in upper lobe predominant lung fibrosis, which is similar to idiopathic pleuroparenchymal fibroelastosis (IPPFE) and has been suggested to be secondary PPFE.
Case presentation:
A 67-year-old man who had worked in an aluminum-processing factory for 50 years visited our hospital complaining of exertional dyspnea. Chest computed tomography (CT) showed bilateral dense sub-pleural consolidation in the upper and middle lung fields, which was consistent with IPPFE; however, the possibility of secondary PPFE associated with aluminosis was not ruled out. Considering the patient's critical condition, trans-bronchial lung biopsy (TBLB) rather than surgical lung biopsy was performed, with elemental analysis of the biopsied specimen. Unfortunately, the specimen obtained by TBLB did not contain alveolar tissue; therefore, pathological diagnosis of PPFE was not possible. However, radiographic findings were highly suggestive of PPFE. On elemental analysis, excessive amounts of aluminum were detected in the bronchiolar walls, establishing a diagnosis of airway aluminosis with likely secondary PPFE resulting from aluminium exposure.
Conclusions:
TBLB with elemental analysis might be useful in differentiating idiopathic PPFE from secondary causes in dust inhalation related disease, such as aluminosis. This case indicated that inhalation of aluminium might cause secondary PPFE, with attention needing to be paid to avoid further exposure.