OpenMed/multicare-articles huggingface dataset:
Case Report: Use of Amniotic Microvesicles for Regenerative Medicine Treatment of a Mare With Chronic Endometritis
Authors: Anna Lange-Consiglio, Federico Funghi, Carlo Cantile, Antonella Idda, Fausto Cremonesi, Pietro Riccaboni
Journal: Front Vet Sci (2020)
Keywords: biopsy, embryo, endometritis, mare, micrornas, microvesicles, regenerative medicine
MeSH terms: Case Reports

Chronic endometritis is an inflammation in the inner layer of uterine mucosa, with or without an infectious process, which affects the animal's fertility but not its general health. A variety of treatments has been adopted over the years but to date, no effective cures have been able to renew the injured tissue. Since the defects in the fetal-maternal communication are caused by degenerative changes due to chronic endometrial inflammation, our working hypothesis was a new approach to this disease by the regenerative medicine using amniotic derived microvesicles (MVs) for their anti-inflammatory and regenerative effects. The MVs are responsible for horizontal transfer of genetic materials, including microRNA (miRNAs) that are involved in paracrine communication between origin cells and target cells. Thus, intrauterine MV infusion may be beneficial in degenerative chronic endometritis and in the fetal-maternal talk. The selected mare was an 11-year-old Friesian, with a history of failed pregnancies despite numerous insemination attempts. Punctual and evident heats characterized the reproductive history, but no insemination attempts had been made for many years. The first (failed) insemination was when the mare was 9-years-old. In the next two reproductive seasons, other attempts were made at regular intervals but none was successful. After a final insemination attempt using a stallion of proven fertility, the collection of an 8-day old embryo suggested that the mare was affected by implantation failure related to endometritis. The mare was treated with two cycles of intrauterine administration of amniotic-derived MVs. The success of the intrauterine administration of MVs was demonstrated by an improvement in the classification of endometritis and in a successful artificial insemination (AI) with implantation of an embryo, as detected at day 14 and with a pregnancy that is still ongoing. Probably, MVs were able to restore the injured endometrium and re-establish the proper communication for a successful embryo implantation.
Celiac Disease Presenting with Immune Thrombocytopenic Purpura
Authors: Hakan Sarbay, Billur Cosan Sarbay, Mehmet Akın, Halil Kocamaz, Mahya Sultan Tosun
Journal: Case Rep Hematol (2017)
MeSH terms: Case Reports

Celiac disease (CD) is an immunological disorder. Clinical manifestations occur as a result of intestinal mucosa damage and malabsorption. CD is also associated with extraintestinal manifestations and autoimmune disorders. The coexistence of CD and autoimmune diseases has been described before. In this article, a patient with CD presenting with thrombocytopenia is discussed.
Apexification in non-vital teeth with immature roots: report of two cases
Authors: Rogério Vieira Silva, Frank Ferreira Silveira, Eduardo Nunes
Journal: Iran Endod J (2015)
Keywords: apexification, apical plug, calcium hydroxide, mta, mineral trioxide aggregate
MeSH terms: Case Reports

Apexification is a method of inducing apical closure for non-vital immature permanent teeth. During this treatment a mineralized barrier is induced [with long term calcium hydroxide (CH) treatment]; or artificially created [with mineral trioxide aggregate (MTA) plug]. This article describes two cases of apexification in immature necrotic teeth treated with these two different techniques. After 6 years of follow-up, clinical and radiographic control showed that both treatments were successful.
A Novel Approach to Treat Traumatized Alveolar Ridges: Two Case Reports
Authors: Mahesh Verma, Sneha Menghani, Jyoti Devi, Rekha Gupta, Shubhra Gill
Journal: Case Rep Dent (2016)

Functional forces are transmitted to the basal seat mucosa through a hard denture base during mastication. Such hard base dentures are not comfortably tolerated in patients with fragile oral mucosa and will cause sore spots, masticatory pain, and further resorption of alveolar bone. Soft liners materials can be advocated successfully to manage such clinical situations. The soft liner material absorbs masticatory forces by means of the cushioning effect and distributes occlusal forces uniformly to prevent trauma to compromised residual ridges.
The Remission of Social Anxiety Disorder After Trauma: A Case Report of Posttraumatic Growth?
Authors: Verônica Hühne, Paula Vigne, Gabriela B de Menezes, Leonardo F Fontenelle
Journal: Front Psychiatry (2021)
Keywords: anxiety disorders, case report, posttraumatic growth, resilience, social anxiety, trauma, traumatic event
MeSH terms: Case Reports

Posttraumatic growth (PTG) describes positive psychological change and improvement beyond one's previous functioning. It manifests as a change of self-perception, improvement in the relationship with others, and a better outlook on life. Despite consistent literature on the occurrence of PTG in healthy subjects, there is still a dearth of studies in people with pre-existing mental disorders, especially anxiety disorders. We report the case of a patient previously diagnosed with social anxiety disorder (SAD), whose symptoms remitted, and life view improved after a traumatic event, illustrating a case of PTG. The trauma shattered the patient's previous belief system, allowing the emergence of a new cognitive schema. Although PTG and symptom remission do not necessarily correspond to the same construct, we believe that these phenomena were related to each other in this case, probably because of a notable change in our patient's underlying belief system.
A Rare Cause of a Fluctuating Cystic Lesion in the External Auditory Canal
Authors: Aaron Esmaili, Allen Y Y Wang, Jafri Kuthubutheen
Journal: Case Rep Otolaryngol (2018)
MeSH terms: Case Reports

Temporomandibular joint (TMJ) ganglionic cyst is an uncommon entity and only a few have been reported in the literature. TMJ ganglion within the external auditory canal presenting clinically as a fluctuating cystic lesion has never been reported. Here, we present a unique case of such a lesion together with otoscopic and radiological images as well as provide a descriptive review of TMJ ganglionic cysts.
Case report: Early carotid stent shortening in patient with radiation-induced carotid stenosis
Authors: Woochan Choi, Yang-Ha Hwang, Yong-Won Kim
Journal: Front Neurol (2023)
Keywords: carotid artery stenosis, carotid stent, closed cell stent, radiation-induced carotid stenosis, stent shortening
MeSH terms: Case Reports

Carotid artery stenting (CAS) for carotid stenosis has been widely used as an alternative treatment in patients not eligible for surgery. The shortening of a carotid stent rarely occurs. We report a case of early shortening of CAS in a patient with radiation-induced carotid stenosis and discuss the potential pathophysiology and strategies for prevention. This case presents a 67-year-old man who underwent radiotherapy for oral cavity squamous cell carcinoma 7 years ago and subsequently developed severe stenosis in the left proximal internal carotid artery. The patient underwent CAS for symptomatic severe carotid stenosis. Follow-up CT angiography revealed shortening of the carotid stent, and additional carotid stenting was performed. We speculate that the possible mechanism of early complication of CAS could be slippage and shortening of the stent due to weak anchoring between the stent strut and the fibrotic arterial wall in radiation-induced carotid stenosis.
HPV 16 Is Related to the Progression of Cervical Intraepithelial Neoplasia Grade 2: A Case Series
Authors: Maria Gabriela Loffredo D'Ottaviano, Michelle Garcia Discacciati, Maria Antonieta Andreoli, Maria Cecília Costa, Lara Termini, Silvia H Rabelo-Santos, Luisa Lina Villa, Luiz Carlos Zeferino
Journal: Obstet Gynecol Int (2013)

Purpose. To describe the acquisition, persistence, and clearance of HPV infection in women with CIN 2 followed up for 12 months. Methods. Thirty-seven women with CIN 2 biopsy, who have proven referral to cervical smear showing low-grade squamous intraepithelial lesions or atypical squamous cells of undetermined significance and tested for HPV, were followed up for one year with cervical smear, colposcopy, and HPV test every three months. HPV DNA was detected by the polymerase chain reaction and genotyping by reverse line blot hybridization assay. Results. CIN 2 regression rate was 49% (18/37), persistence as CIN 1 or CIN 2 was 22% (8/37), and progression to CIN 3 was 29% (11/37). Multiple HPV types were observed at admission in 41% (15/37) of cases. HPV 16 was detected at admission in 58% (11/19) of the cases that persisted/progressed and in 39% (7/18) of the cases that regressed. HPV 16 was considered possibly causal in 67% (10/15) of the cases that persisted or progressed and in 10% (1/10) of the cases that regressed (P = 0.01). Conclusion. Multiple HPV infections were frequently detected among women with CIN 2 at admission and during the followup. The CIN 2 associated with HPV 16 was more likely to persist or to progress to CIN 3.
An Undiagnosed Paraganglioma in a 58-Year-Old Female Who Underwent Tumor Resection
Authors: William C Fox, Matthew Read, Richard E Moon, Eugene W Moretti, Brian J Colin
Journal: Case Rep Anesthesiol (2017)
MeSH terms: Case Reports

Paragangliomas and pheochromocytomas are rare neuroendocrine tumors that can have high morbidity and mortality if undiagnosed. Here we report a case of an undiagnosed paraganglioma in a 58-year-old female who underwent tumor resection. The patient became severely hypertensive intraoperatively with paroxysmal swings in blood pressure and then later became acutely hypotensive after tumor removal. She was managed in the surgical intensive care unit (SICU) postoperatively and discharged from the hospital without acute complications. We briefly discuss the epidemiology, clinical presentation, perioperative management, and possible complications of these tumors to assist healthcare providers if one were to encounter them.
Case Report: Azathioprine: An Old and Wronged Immunosuppressant
Authors: Pedro R Chocair, Precil Diego Miranda de Menezes Neves, Sara Mohrbacher, Maurilio Pacheco Neto, Victor A H Sato, Érico S Oliveira, Leonardo V Barbosa, Alessandra M Bales, Fagner Pereira da Silva, Américo L Cuvello-Neto, John A Duley
Journal: Front Immunol (2022)
Keywords: 6-tgn, allopurinol, azathioprine, metabolites, mycophenolate, renal transplant
MeSH terms: Azathioprine, Kidney Transplantation, Case Reports, Research Support, Non-U.S. Gov't, Enzyme Inhibitors, Humans, Immunosuppressive Agents / adverse effects, Thioguanine / therapeutic use, Enzyme Inhibitors, Immunosuppressive Agents, Thioguanine, Azathioprine

Mycophenolate rapidly substituted azathioprine (AZA) in transplant immunosuppression regimens since the 1990s, when early clinical trials indicated better outcomes, although opposite results were also observed. However, none of these trials used the well-established optimization methods for AZA dosing, namely, thiopurine methyltransferase pharmacogenetics combined with monitoring of the thiopurine metabolites 6-thioguanine nucleotides (6-TGN) and 6-methylmercaptopurine (6-MMP). Resistance to optimize AZA therapy remains today in transplant therapy, despite the fact that thiopurine metabolite testing is being used by other medical disciplines with evident improvement in clinical results. In a previous analysis, we found that active 6-TGN metabolites were not detectable in about 30% of kidney transplant patients under continuous use of apparently adequate azathioprine dosage, which demonstrates the need to monitor these metabolites for therapeutic optimization. Two of four case studies presented here exemplifies this fact. On the other hand, some patients have toxic 6-TGN levels with a theoretically appropriate dose, as seen in the other two case studies in this presentation, constituting one more important reason to monitor the AZA dose administered by its metabolites. This analysis is not intended to prove the superiority of one immunosuppressant over another, but to draw attention to a fact: there are thousands of patients around the world receiving an inadequate dose of azathioprine and, therefore, with inappropriate immunosuppression. This report is also intended to draw attention, to clinicians using thiopurines, that allopurinol co-therapy with AZA is a useful therapeutic pathway for those patients who do not adequately form active thioguanine metabolites.
Anxiolysis in the Surgical Management of a Compound Odontoma in a Pediatric Patient
Authors: Pier Paolo Poli, Luca Creminelli, Emma Grecchi, Silvia Pieriboni, Gregorio Menozzi, Carlo Maiorana
Journal: Case Rep Dent (2019)
MeSH terms: Case Reports

Among odontogenic tumors, odontoma is the most frequent. The common treatment contemplates a conservative approach. While this procedure is generally accepted and tolerated, some difficulties may be encountered in the case of pediatric patients. Indeed, negative feelings of tension, apprehension, nervousness, and fear are likely to occur. The present report is aimed at discussing the management of a compound odontoma in a pediatric patient under anxiolysis with diazepam on an outpatient basis. The surgery was carried out without complications, and the discharge was completed safely. Oral premedication with diazepam should be considered to avoid more invasive sedation procedures in anxious pediatric patients.
The Claustrum Sign in Febrile Infection-Related Epilepsy Syndrome (FIRES)
Authors: Kelly Di Dier, Lucas Dekesel, Sven Dekeyzer
Journal: J Belg Soc Radiol (2023)
Keywords: fires, norse, claustrum sign, magnetic resonance imaging, neuroradiology
MeSH terms: Case Reports

Teaching Point: Bilateral mesiotemporal edema and the claustrum sign can be seen in febrile infection-related epilepsy syndrome (FIRES) and new onset refractory status epilepticus (NORSE) but are neither diagnostic nor pathognomonic for these entities.
Anesthetic Management of a Child with Mitochondrial Neurogastrointestinal Encephalopathy
Authors: Vianey Q Casarez, Acsa M Zavala, Pascal Owusu-Agyemang, Katherine Hagan
Journal: Case Rep Anesthesiol (2015)

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an autosomal recessive disorder associated with deficiency of thymidine phosphorylase (TP). Associated manifestations include visual and hearing impairments, peripheral neuropathies, leukoencephalopathy, and malnutrition from concomitant gastrointestinal dysmotility and pseudoobstruction. Given the altered metabolic state in these patients, specific consideration of medication selection is advised. This case report will describe the anesthetic management used in a 10-year-old girl with MNGIE. She had multiple anesthetics while undergoing allogeneic hematopoietic stem cell transplantation. This case report will discuss the successful repeated use of the same anesthetic in this pediatric patient, with the avoidance of volatile anesthetic agents, propofol, and muscle relaxant.
Glomus Tumor Presenting as Raynaud's Phenomenon
Authors: M H Abdelrahman, M Hammoudeh
Journal: Case Rep Med (2012)

Glomus tumors are rare tumors that often include hands and feet; they present characteristically with paroxysmal pain, exquisite point tenderness, and cold sensitivity. Such diagnosis needs to be confirmed by imaging like ultrasound and magnetic resonance imaging (MRI). Surgical excision is the treatment of choice for glomus tumors. There are only few case reports of glomus tumors in association with Raynaud's phenomenon; this is considered to be the 4th case.
Facial skin metastasis of colorectal cancer: a case report
Authors: Zilvinas Saladzinskas, Algimantas Tamelis, Saulius Paskauskas, Darius Pranys, Dainius Pavalkis
Journal: Cases J (2010)

Introduction:
Liver and lungs are common locations of distant metastases of colorectal cancer. Skin metastases of colorectal cancer are very rare, and facial lesions are extremely uncommon.
Case presentation:
An anterior resection of the rectum was performed for rectal cancer T3N0M0G3. A small ulcer on the upper lip developed 3.5 years after primary operation. Metastasis of adenocarcinoma was confirmed histologically, and local excision was performed. At the same time, a solitary metastasis in the right lung was diagnosed, and the right lower lobectomy was performed. No other metastasis or local recurrences were observed during the next 7 months.
Conclusion:
Skin metastases in the face from colorectal cancer are very rare and may indicate tumour relapse several years after primary resection. These patients have a worse prognosis.
Historical Case of Cervical Penetrating Wound: From First Aid to Surgical Intervention
Authors: Koné Fatogoma Issa, Keïta Mohamed Amadou, Soumahoro Siaka, Konaté N'faly, Diarra Kassim, Timbo Samba Karim
Journal: Case Rep Otolaryngol (2017)
MeSH terms: Case Reports

Objective:
We report a case of cervical penetrating wound by posing the problem of its support and by analyzing the chain of survival of a patient to human sacrifice.
Case report:
It was an 11-year-old boy admitted to the hosting service of cervical penetrating wound emergency occurring in a context of human sacrifice by weapon (knife). On admission, the conscious patient had a left cervical hematoma at the level of the cervical zone II and severe signs of acute anemia. The exploratory cervicotomy, carried out 12 hours after the trauma under transfusion, allowed us to highlight a section of the front edge of the sternocleidomastoid and previous jugular muscles under hyoid. We noted the presence of a linear wound of 1 cm at the level of the left internal jugular vein. The wound of the internal jugular vein has been repaired with the Prolene 4.O. The outcome was good, allowing the exit 10 days after cervicotomy.
Conclusion:
The causal circumstances of cervical penetrating wounds are diverse. Their importance or their severity depends on the causative circumstances dominated by aggression and attempts to autolysis. Human sacrifice, with use of the weapon, is an exceptional circumstance.
Transcranial magnetic stimulation therapy for focal leg dystonia: a case report
Authors: Kush Sharma, Alberto Cucca, Andrea Lee, Shashank Agarwal, Steven Joel Frucht, Milton Cesar Biagioni
Journal: J Clin Mov Disord (2019)
Keywords: dystonia therapy, focal dystonia, repetitive transcranial magnetic stimulation, task-specific dystonia
MeSH terms: Case Reports

Background:
Dystonia is a debilitating disease that causes abnormal, often repetitive, movements, postures or both. The pathophysiology is unknown but related to loss of neuronal inhibition, aberrant sensorimotor integration, and/or derangements of synaptic plasticity. Current treatments include pharmacotherapy, botulinum toxin injections and deep brain stimulation (DBS). The response to these treatments are often limited and carry the risk of side effects requiring alternative therapies such as non-invasive brain stimulation.
Case presentation:
We present a case report of a 65-year -old man with refractory focal 'task-specific' dystonia. The treatment plan included 10-daily sessions of 1 Hz, 2600 pulses of repetitive transcranial magnetic stimulation (rTMS) targeting the primary motor cortex.
Conclusion:
There were no clinical benefits noticed. Currently, there are no rTMS protocol treatments for dystonia. Publication of negative results will help in refining the optimal stimulation parameters, thus maximizing the effectiveness and reproducibility of future therapeutic protocols.
Case report: Birk-Landau-Perez syndrome linked to the SLC30A9 gene-identification of additional cases and expansion of the phenotypic spectrum
Authors: Praseetha Kizhakkedath, Watfa AlDhaheri, Ibrahim Baydoun, Mohammed Tabouni, Anne John, Taleb M Almansoori, Saeed Al-Turki, Fatma Al-Jasmi, Hiba Alblooshi
Journal: Front Genet (2023)
Keywords: bilapes, ataxia, developmental regression, hyperechogenic kidneys, oculomotor apraxia, tubulointerstitial nephritis, zinc transporter
MeSH terms: Case Reports

Birk-Landau-Perez syndrome (BILAPES) is an autosomal recessive cerebro-renal syndrome associated with genetic defects in the SLC30A9 gene, initially reported in 2017 in six individuals belonging to a large Bedouin kindred. The SLC30A9 gene encodes a putative mitochondrial zinc transporter with ubiquitous expression, the highest found in the brain, kidney, and skeletal muscle. Since the first report, only one additional affected patient has been described, but there were some inconsistencies, such as hearing loss, failure to thrive, and neuroimaging findings between the clinical presentation of the disease in the Bedouin family and the second patient. Here, we present two more patients from a consanguineous Middle Eastern family with features of chronic kidney disease, neurodevelopmental regression, ataxia, hearing loss, and eye abnormalities, which were largely consistent with BILAPES. Whole-exome sequencing detected a homozygous in-frame deletion c.1049_1051delCAG (p.Ala350del) in the SLC30A9 gene, which was the same variant detected in the patients from the primary literature report and the variant segregated with disease in the family. However, in the patients described here, brain MRI showed cerebellar atrophy, which was not a cardinal feature of the syndrome from the primary report. Our findings provide further evidence for SLC30A9-associated BILAPES and contribute to defining the clinical spectrum.
Alteration of Occlusal Plane in Orthognathic Surgery: Clinical Features to Help Treatment Planning on Class III Patients
Authors: Daniel Amaral Alves Marlière, Tony Eduardo Costa, Saulo de Matos Barbosa, Rodrigo Alvitos Pereira, Henrique Duque de Miranda Chaves Netto
Journal: Case Rep Dent (2018)
MeSH terms: Case Reports

Dentofacial deformities (DFD) presenting mainly as Class III malocclusions that require orthognathic surgery as a part of definitive treatment. Class III patients can have obvious signs such as increasing the chin projection and chin throat length, nasolabial folds, reverse overjet, and lack of upper lip support. However, Class III patients can present different facial patterns depending on the angulation of occlusal plane (OP), and only bite correction does not always lead to the improvement of the facial esthetic. We described two Class III patients with different clinical features and inclination of OP and had undergone different treatment planning based on 6 clinical features: (I) facial type; (II) upper incisor display at rest; (III) dental and gingival display on smile; (IV) soft tissue support; (V) chin projection; and (VI) lower lip projection. These patients were submitted to orthognathic surgery with different treatment plannings: a clockwise rotation and counterclockwise rotation of OP according to their facial features. The clinical features and OP inclination helped to define treatment planning by clockwise and counterclockwise rotations of the maxillomandibular complex, and two patients undergone to bimaxillary orthognathic surgery showed harmonic outcomes and stables after 2 years of follow-up.
Acute Myocardial Infarction following Naltrexone Consumption; a Case Report
Authors: Bita Dadpour, Arash Gholoobi, Shahrad Tajoddini, Amir Habibi
Journal: Emerg (Tehran) (2017)
Keywords: naltrexone, myocardial infarction, narcotic antagonists, substance withdrawal syndrome
MeSH terms: Case Reports

Cardiovascular effects of opioid withdrawal have long been studied. It was reported that patients with underlying ischemic heart disease and atherosclerotic vessels may be complicated by a sudden physical and emotional stress due to withdrawal syndrome. But some other believes sudden increase in catecholamine level as a sympathetic overflow might effect on heart with and without underlying ischemia. In the current study, a patient on methadone maintenance therapy (MMT) who experienced myocardial infarction (MI) after taking naltrexone was described.