OpenMed/multicare-articles huggingface dataset:
Scorpion sting and allergic reaction to scorpion venom: A case-based review
Authors: Jozélio Freire de Carvalho
Journal: Allergol Select (2024)
Keywords: allergy, envenomation, scorpion, scorpionism, urticaria
MeSH terms: Review

Objective:
To describe a young patient with scorpion sting (SS) with typical lesions of urticaria besides the local SS clinical picture.
Materials and methods:
A systematic screening of articles dating from 1966 to 2021 was conducted in the main databases. All articles included the association between SS and urticaria. A new case report is added to the published list.
Results:
The literature search found 5 articles with 29 patients with SS and urticaria/allergic reactions. We performed our analysis by adding our present case, resulting in a total of 30 cases. Most were male, and their ages varied from 29 to 48 years. Regarding SS severity, most were mild or moderate. In two articles, patients had more than one sting. The allergic reaction varied from urticaria, pruritus, flushing, angioedema, wheezing, rhinorrhea, sneezing, consciousness alterations, and gastrointestinal and cardiovascular alterations. In 5/6 (83%) articles, the patients were alive at the study time. One subject died from anaphylactic shock.
Conclusion:
The present article systematically reviewed all published cases of SS and allergic reactions to scorpion venom. It is an infrequent association; most patients are male and in the productive age, and reaction may vary from mild to severe, including death.
Case report: A healthy baby achieved after preimplantation genetic testing from an infertile woman with hereditary leiomyomatosis and renal cell cancer syndrome
Authors: Qianhui Hu, Qing Zhang, Mengxi Guo, Haixia Ding, Ji Xi, Meiling Zhang, Min Wang, Lin Zhang, Shuyuan Li, Dandan Wu, Wen Li
Journal: Front Med (Lausanne) (2024)
Keywords: pgt-m, case report, embryo transplantation, hereditary leiomyomatosis and renal cell cancer, uterine leiomyomas
MeSH terms: Case Reports

Background:
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a rare autosomal dominant inheritable disease caused by Fumarate hydratase (FH) gene germline mutation. It is speculated that for HRLCC infertility women with multiple uterine leiomyomas, preimplantation genetic testing may help block transmission of mutated FH gene during pregnancy.
Case presentation:
We present the case of a 26-year-old nulligravida with a history of early-onset uterine leiomyomatosis had a heterozygous nonsense mutation [NM_000143.4 (FH): c.1027C > T(p.Arg343Ter)] in the HRLLC gene. After ovulation induction and in vitro fertilization, preimplantation genetic testing for monogenic disorders (PGT-M) on embryos revealed the absence of the pathogenic allele in two blastomeres. Uterine fibroids were identified before embryo transfer, leading to a submucosal myomectomy and long period of pituitary suppression by Gonadotropin-releasing hormone analog (GnRHa). The patient achieved a healthy live birth after the second cycle of frozen-thawed embryo transfer.
Conclusion:
This case details the successful treatment of an infertile patient with an HRLLC family history, resulting in a healthy birth through myomectomy and PGT-M selected embryo transplantation. Our literature search indicates the first reported live birth after HRLLC-PGT-M.
Enhancing Efficacy and Quality of Life in Patients with Herpes Zoster Infection in Hairy Cell Leukemia
Authors: Xiaowei Feng, Yuchen Tao, Qi Hu, Yuanxia Liu, Jizhang Bao, Wenwen Jiang
Journal: Case Rep Hematol (2024)
MeSH terms: Case Reports

Hairy cell leukemia (HCL) is an infrequent and persistent B-cell inert lymphoid leukemia. In this study, we present the case of a 71-year-old female patient with a previous diagnosis of variant HCL who experienced a severe herpes zoster infection leading to an extensive skin eruption. The patient's initial diagnosis of HCL occurred 7 years ago, and she underwent treatment with cladribine, interferon, COP (cyclophosphamide, vincristine, and prednisone), benztropine tablets + clarithromycin dispersible, and ibrutinib. Immune disorders resulting from repeated prior chemotherapy and targeted therapy may potentially precipitate herpes zoster infection. Despite an initial two-week period of unresponsiveness to antivirals and nerve nutrition treatments, the introduction of topical Coptis liquid to the treatment regimen yielded significant efficacy. This case report underscores the potential of Chinese medicine as an adjunct to conventional antiviral therapy in the management of herpes zoster infection in immunocompromised patients. This treatment protocol has the potential to enhance efficacy, enhance quality of life, and serve as a more robust foundation for clinical diagnosis and improved treatments.
Case Report: Progressive disease of BRCA2-mutant colon adenocarcinoma following talazoparib therapy
Authors: Elizaveta Polyanskaya, Alexandra Lebedeva, Olesya Kuznetsova, Ekaterina Belova, Alexandra Kavun, Maxim Ivanov, Mikhail Fedyanin, Alexey Tryakin, Vladislav Mileyko, Dmitry Nosov
Journal: Front Oncol (2023)
Keywords: brca2, mtb, parp inhibitors, case report, colorectal cancer, talazoparib
MeSH terms: Case Reports

Colorectal cancer (CRC) is currently one of the most common tumor types diagnosed worldwide. In the early stages, the disease responds well to surgical and chemotherapeutic treatment, but in the later stages when therapeutic options are exhausted, comprehensive genomic profiling can guide further treatment decisions. We present the case of a 46-year-old man of Ashkenazi Jewish ancestry who was diagnosed with KRAS-mutated metastatic colorectal cancer. After surgery and progression on standard FOLFOX/FOLFIRI + bevacizumab therapy, as well as on Trifluridine/Tipiracil, comprehensive genomic profiling was performed with the hope of expanding therapeutic options. Following comprehensive tumor molecular profiling via NGS, a discussion of the case was discussed at the local molecular tumor board in order to determine further treatment strategy. An activating variant of KRAS and PIK3CA, FLT3 and SRC amplification and damaging TP53 and APC variants were discarded by MTB as potential targetable biomarkers. The BRCA2 p.S1415fs*4 founder frameshift variant was of interest and the patient was included in the clinical trial investigating the efficacy of a PARP inhibitor talazoparib. Unfortunately, the disease progression was detected within one month of talazoparib treatment and the patient died during the 8th cycle of FOLFIRI + bevacizumab therapy rechallenge.
The Role of Colon in Isolated Intestinal Transplantation: Description of 4 Cases
Authors: Pierpaolo Di Cocco, Giulia Bencini, Alessandro Martinino, Egor Petrochenkov, Stepan Akshelyan, Kentaro Yoshikawa, Mario Spaggiari, Jorge Almario-Alvarez, Ivo Tzvetanov, Enrico Benedetti
Journal: Int J Surg Oncol (2024)
MeSH terms: Colon / surgery, Colon / transplantation, Case Reports, Adult, Female, Humans, Intestines / surgery, Intestines / transplantation, Male, Middle Aged

Intra-abdominal desmoid tumors are a rare and complex clinical problem. These tumors are locally invasive, and surgical ablation represents the mainstay of treatment. When localized at the root of the mesentery, their resection may require extensive excision of the intestine resulting in intestinal failure and life-long total parenteral nutrition. Intestinal transplantation, either autotransplantation or allotransplantation, has been used as a viable option to treat this group of patients. Herein, we describe a series of 4 patients with unresectable intra-abdominal desmoid tumor who underwent cadaveric isolated intestinal and ascending colon transplantation.
PARTIAL DISTAL DUODENECTOMY IN PATIENT WITH ADENOCARCINOMA
Authors: Héctor Losada, Norberto Portillo, Andrés Troncoso, Renato Becker, Rocio Vera
Journal: Arq Bras Cir Dig (2024)
MeSH terms: Adenocarcinoma / pathology, Adenocarcinoma / surgery, Duodenum / surgery, Case Reports, Aged, Anastomosis, Surgical, Biopsy, Female, Humans, Pancreaticoduodenectomy, Treatment Outcome

Background:
Duodenal adenocarcinoma is a small percentage of gastrointestinal neoplasms, around 0.5%, and its treatment is based on resection of the tumor, classically by pancreaticoduodenectomy. In recent years, however, segmental resections of duodenal lesions, that do not involve the second portion or the periampullary region, have gained relevance with good surgical and oncological outcomes as well as the benefit of avoiding surgeries that can result in high morbidity and mortality.
Aims:
To report a case of an elderly female patient with malignant neoplastic lesion in the third and fourth duodenal portion, non-obstructive, submitted to surgical treatment.
Methods:
The technical option was the resection of the distal duodenum and proximal jejunum with preservation of the pancreas and reconstruction with side-to-side duodenojejunal anastomosis.
Results:
The evolution was satisfactory and the surgical margins were free of neoplasia.
Conclusions:
Segmental resections of the duodenum are feasible and safe, offering the benefit of preventing complications of pancreaticoduodenectomies.
Repeated misdiagnosis of small intestine bronchogenic cyst: a case report
Authors: Xiaodong Chen, Danfei Hu, Wenbo Gao, Qihang Wu, Xiangcheng Qin, Zhichao Wang, Yangkai Xu, Dong Chen, Nan Li, Guobin Weng
Journal: Front Oncol (2024)
Keywords: case report, ectopic bronchogenic cyst, misdiagnosis, small intestine bronchogenic cyst, surgery
MeSH terms: Case Reports

Bronchogenic cysts are uncommon congenital malformations of the respiratory system. These cysts can be categorized as intrapulmonary, mediastinal, or ectopic. Ectopic bronchogenic cysts, which lack distinctive clinical and imaging features, are particularly challenging to diagnose. This study presents a 48-year-old woman having a small intestinal bronchogenic cyst. She was repeatedly misdiagnosed as having an ovarian chocolate cyst or a cystic mass of bladder origin three years ago. However, no cyst was found during the operation. Half a year prior to presenting at our hospital, the patient developed frequent urination, prompting her to seek further treatment. We eventually discovered a cyst in the small intestine. The histological evaluation of the specimen showed a bronchogenic cyst. Small intestine bronchogenic cysts are extremely rare and easily misdiagnosed. It should be considered as one of the differential diagnoses of pelvic cysts. Particularly, when intraoperative exploration of the pelvic cavity fails to detect any cysts, consideration should be given to the possibility of small intestine bronchogenic cysts.
Case report: "Scared to deaf": medical-legal evaluation of a suspected post -traumatic stress disorder"
Authors: Emanuele Capasso, Mariagrazia Marisei, Marco Macculi, Pierpaolo Di Lorenzo
Journal: Front Psychiatry (2024)
Keywords: ptsd, barotrauma, medical-legal assessment, post-traumatic stress disorder, psychiatry, soldier
MeSH terms: Case Reports

The case concerns the alleged failure by the resisting administration to fulfill obligations arising from the contract and employment relationship, as well as the violation of safety regulations leading to the workplace accident reported by an Airforce Sergeant. Following the accident, the soldier complains of developing barotraumatic hearing loss with tinnitus and reactive post-traumatic stress disorder to the traumatic event. The case provides an opportunity to analyze the relevance of forensic medical assessment and its integration with psychodiagnostic examination for the correct nosographic classification aimed at evaluating and quantifying biological damage.
Zanubrutinib-induced aseptic meningitis: a case report and literature review
Authors: Jinjun Yang, Lian Wang, Xiao Zhong, Chenlu Yang, Yu Wu
Journal: Front Pharmacol (2023)
Keywords: zanubrutinib, aseptic meningitis, bruton tyrosine kinase, follicular lymphoma, hematological diseases
MeSH terms: Case Reports

Zanubrutinib is a Bruton tyrosine kinase (BTK) inhibitor used in B cell malignancy treatment and is generally well tolerated in most patients. Zanubrutinib-induced aseptic meningitis is currently not reported. Herein, we present the first case of zanubrutinib-induced aseptic meningitis. A 33-year-old woman was diagnosed with relapsed/refractory follicular lymphoma and subsequently developed aseptic meningitis after receiving zanubrutinib treatment. We reviewed the literature and uncovered the lack of current reports on zanubrutinib or other BTK inhibitor-induced aseptic meningitis. Moreover, we summarized cases on aseptic meningitis induced by common chemotherapy and targeted drugs used for hematological diseases. Drug-induced aseptic meningitis (DIAM) is a drug-induced meningeal inflammation. The possible pathogenesis is the direct stimulation of the meninges via intrathecal injection of chemotherapy drugs and immune hypersensitivity response caused by immunosuppressive drugs. It is more common in women with immune deficiency and mainly manifests as persistent headache and fever. Cerebrospinal fluid examinations mainly demonstrate a significant increase in cells and proteins. DIAM diagnosis needs to exclude bacterial, fungal, viral, and tuberculosis infections; neoplastic meningitis; and systemic diseases involving the meninges. The prognosis of DIAM is usually favorable, and physicians should detect and stop the causative drug. In conclusion, zanubrutinib-induced aseptic meningitis is a rare but serious complication, and physicians should be promptly aware of this adverse event to avoid serious consequences.
Minimally invasive management of combined esophageal atresia with tracheoesophageal fistula and duodenal atresia: a comprehensive case report
Authors: Eunyoung Jung
Journal: Front Pediatr (2023)
Keywords: duodenal atresia, esophageal atresia, laparoscopy, minimally invasive surgical procedures, thoracoscopy, tracheoesophageal fistula
MeSH terms: Case Reports

A newborn presented with a rare combination of esophageal atresia with tracheoesophageal fistula (EA/TEF) and duodenal atresia (DA), which was successfully managed using minimally invasive surgical techniques. The patient was a 1-day-old male for whom passing a feeding tube was infeasible and who had a double bubble sign on radiography. The neonate underwent a thoracoscopic ligation of the tracheoesophageal fistula (TEF) and a laparoscopic duodeno-duodenostomy on the same day, resulting in stabilized vital signs. Ten days after the initial operation, a thoracoscopic esophago-esophagostomy was successfully performed. The patient demonstrated full feeding capability and normal weight gain after the surgeries. The co-occurrence of EA/TEF and DA is a rare and complex anomaly. This case indicates that minimally invasive techniques can effectively manage this condition.
Gallbladder cancer masquerading as xanthogranulomatous cholecystitis: a case report and literature review
Authors: Xu Deng, Chun-Yuan Yang, Wei Tian, Zong-Long Zhu, Jian-Xing Tian, Rui Huang, Ming Xia, Wei Pan
Journal: Front Oncol (2024)
Keywords: surgery 5, gallbladder cancer (gbc), laparoscopic cholecystectomy (lc), pathology, xanthogranulomatous cholecystitis (xgc)
MeSH terms: Case Reports

Xanthogranulomatous cholecystitis (XGC) is a rare type of cholecystitis that, despite being benign poses diagnostic challenges due to its low prevalence and need for consensus on diagnostic criteria. Consequently, distinguishing XGC from gallbladder cancer (GBC) is challenging, leading to clinical misdiagnoses. This article presents a case where a patient initially diagnosed with GBC was later found to have XGC.
When the Gut Took a Wrong Turn to the Right: A Case Report of a Rare Complication of Closed Loop Small Bowel Obstruction With Small Bowel Volvulus in a Right Paraduodenal Hernia With Midgut Malrotation
Authors: Samanvitha H, Sushmitha Puttappa Shivagange, Shantkumar S Sajjan, Naveen S G, Harsha M T
Journal: Cureus (2024)
Keywords: closed-loop obstruction, gut malrotation, internal hernia, right paraduodenal hernia, small bowel obstruction, strangulation, volvulus
MeSH terms: Case Reports

Internal hernias constitute 5.8% of all small bowel obstructions. The right paraduodenal hernia is a less common subtype of the paraduodenal hernia. Lack of specific signs and symptoms precludes its clinical diagnosis, which emphasizes the need for computed tomography in diagnosis. We present a case of a 24-year-old male patient with a right paraduodenal hernia and midgut malrotation causing closed loop small bowel obstruction and small bowel volvulus within the hernial sac who underwent laparoscopy-assisted reduction of hernia and adhesiolysis with closure of the peritoneal defect. Since the right paraduodenal hernia is associated with gut malrotation, risk of strangulation, closed-loop obstruction, and rarely volvulus, these patients need prompt radiological diagnosis and surgical intervention.
Is there any difference between the owners and the public in their visual impact assessments?--A case study of the front garden of multi-storey residential buildings
Authors: Tao Gu, Chenping Han, Mengmeng Zhao, Lin Zhang, Zhongju Yang, Jian Zhang
Journal: PLoS One (2024)
MeSH terms: Gardening, Plants, China, Gardens, Research Design

As a special garden unique to China, the front garden of multi-storey residential buildings has certain public attributes but is managed by a single owner. In this study, the front gardens of multi-storey residential buildings in Jiangsu province, China, were set as research object. Meanwhile, the size of garden, plant type, plant vertical structure, color number, plant coverage, and fence material were chosen as the landscape features to be explored. Then the experiments were conducted to reveal the visual impact assessment rendered by the public with different demographic attributes and the results obtained were analyzed. As is indicated by the statistical analysis, significant differences exist between the owners and the public in their visual impact assessments of the front gardens; the six landscape features are the main factors that influence the public's visual impact assessment; and the public with different demographic attributes would render different visual impact assessments of front gardens. This study offers valuable help for the design of front gardens of multi-storey residential buildings.
Infertility in Fabry's Disease: role of hypoxia and inflammation in determining testicular damage
Authors: Luigi Sansone, Federica Barreca, Manuel Belli, Michele Aventaggiato, Andrea Russo, Giulietta A Perrone, Matteo A Russo, Marco Tafani, Andrea Frustaci
Journal: Front Endocrinol (Lausanne) (2024)
Keywords: fabry’s disease, cellular and molecular rehabilitation, hypoxia, inflammation, new therapeutic targets for infertility rehabilitation, testicular damage
MeSH terms: Fabry Disease / complications, Fabry Disease / pathology, Infertility / pathology, Case Reports, Adult, Humans, Hypoxia / pathology, Inflammation / complications, Inflammation / pathology, Male, Oxygen, Testis / pathology, Oxygen, NFKB1 protein, human, HIF1A protein, human

Introduction:
Fabry's disease (FD) is a genetic X-linked systemic and progressive rare disease characterized by the accumulation of globotriaosylceramide (GB3) into the lysosomes of many tissues. FD is due to loss-of-function mutations of α-galactosidase, a key-enzyme for lysosomal catabolism of glycosphingolipids, which accumulate as glycolipid bodies (GB). In homozygous males the progressive deposition of GB3 into the cells leads to clinical symptoms in CNS, skin, kidney, etc. In testis GB accumulation causes infertility and alterations of spermatogenesis. However, the precise damaging mechanism is still unknown. Our hypothesis is that GB accumulation reduces blood vessel lumen and increases the distance of vessels from both stromal cells and seminiferous parenchyma; this, in turn, impairs oxygen and nutrients diffusion leading to subcellular degradation of seminiferous epithelium and sterility.
Methods:
To test this hypothesis, we have studied a 42-year-old patient presenting a severe FD and infertility, with reduced number of spermatozoa, but preserved sexual activity. Testicular biopsies were analyzed by optical (OM) and transmission electron microscopy (TEM). Activation and cellular localization of HIF-1α and NFκB was analyzed by immunofluorescence (IF) and RT-PCR on homogeneous tissue fractions after laser capture microdissection (LCMD).
Results:
OM and TEM showed that GB were abundant in vessel wall cells and in interstitial cells. By contrast, GB were absent in seminiferous epithelium, Sertoli's and Leydig's cells. However, seminiferous tubular epithelium and Sertoli's cells showed reduced diameter, thickening of basement membrane and tunica propria, and swollen or degenerated spermatogonia. IF showed an accumulation of HIF-1α in stromal cells but not in seminiferous tubules. On the contrary, NFκB fluorescence was evident in tubules, but very low in interstitial cells. Finally, RT-PCR analysis on LCMD fractions showed the expression of pro-inflammatory genes connected to the HIF-1α/NFκB inflammatory-like pathway.
Conclusion:
Our study demonstrates that infertility in FD may be caused by reduced oxygen and nutrients due to GB accumulation in blood vessels cells. Reduced oxygen and nutrients alter HIF-1α/NFκB expression and localization while activating HIF-1α/NFκB driven-inflammation-like response damaging seminiferous tubular epithelium and Sertoli's cells.
Unaddressed regulatory issues in xenotransplantation: a hypothetical example
Authors: Koko Kwisda
Journal: Front Transplant (2023)
Keywords: biotechnology, genome editing technologies, interspecies blastocyst complementation, organ shortage, regulation, transgenic pigs, transplantation, xenotransplantation

The last few years have seen a significant increase in the use of technology to manipulate genetic sequences and generate animals as a source of xeno-organs. This has made the generation of genetically bespoke organisms a reality. This paper will analyze the regulatory and practical aspects of such an innovative approach to xenotransplantation on the basis of a hypothetical case study applied to Germany and highlight the gaps in the current regulation. This paper thus provides the basis for legal debate within a specific country. In addition, the identified gaps also pose a barrier toward the harmonization of international regulation. This publication therefore lays the groundwork for guiding the international debate regarding the regulatory framework for solid organ xenotransplantation toward specific issues.