OpenMed/multicare-articles huggingface dataset:
Characteristics of tumor thrombosis in the inferior mesenteric vein from colorectal cancer: A report of three cases and review of the literature
Authors: Shota Izukawa, Hiroyuki Mushiake, Takuo Watanabe, Tetsushi Ishiguro, Kenki Segami, Tadao Fukushima
Journal: Int J Surg Case Rep (2023)
Keywords: case report, colorectal cancer, inferior mesenteric vein, tumor thrombosis
MeSH terms: Case Reports

Introduction:
Intravenous tumor thrombosis is a rare condition in colorectal cancer and shows a locally aggressive biological behavior. We herein report three cases of colorectal cancer with tumor thrombosis in the inferior mesenteric vein (IMV) treated by colorectal resection combined with resection of the IMV under laparoscopic surgery.
Case presentation:
In these three colorectal cancer patients with IMV tumor thrombus, IMV tumor thrombus was detected in all instances on preoperative computed tomography. Preoperative chemotherapy was also performed in one patient with concurrent liver metastasis. All patients underwent laparoscopic locally R0 resection; however, the pathological findings showed a positive margin for IMV resection in all patients.
Clinical discussion:
We reviewed 19 previously reported cases along with our 3 present cases and clarified the characteristics of colorectal cancer accompanied by IMV tumor thrombosis. IMV tumor thrombosis may be a risk factor for liver metastasis and R1 resection, and systemic treatment, including neoadjuvant chemotherapy (NAC), may be quite important.
Conclusion:
IMV tumor thrombosis may have a tendency to cause hematogenous metastasis. Systemic therapy, including NAC, may be useful, but since this is a rare condition, the accumulation of further cases is needed.
Pericardial Tamponade following Asymptomatic SARS-CoV-2 Infection: A Diagnostic Journey
Authors: Christian Birner, Matthias Gasche, Rainer Voisard, Christian Neumann
Journal: Case Rep Cardiol (2022)
MeSH terms: Case Reports

Background. Pericardial tamponade is a known life-threatening condition rarely reported in COVID-19 but has not been reported following asymptomatic SARS-CoV-2 infection. Its pathomechanism is still elusive. Case Summary. We report the case of a 66-year-old man with progressive shortness of breath and leg swelling due to new-onset heart failure and pericardial tamponade following asymptomatic SARS-CoV-2 infection. Ultrasound-guided placement of a pericardial drainage led to significant improvement of symptoms and revealed an exudative effusion. Throughout the diagnostic process, we were confronted with a systemic inflammatory syndrome suspicion of an induced autoimmune condition. After steroid pulse therapy and oral anticoagulation for subclavian vein thrombosis, the patient was discharged and followed in our outpatient clinic. Discussion. Patients with asymptomatic SARS-CoV-2 infection are at risk for developing life-threatening complications. Induced autoimmune conditions could be a potential explanation for late-onset pericardial tamponade in this population. A multimodal imaging approach is crucial in the diagnosis and characterization of cardiac inflammation. An interdisciplinary approach is essential. Awareness of uncommon cardiac complications following a SARS-CoV-2 infection is crucial for the initial assessment and the appropriate treatment of these patients.
Sellar Metastasis of Cervical Adenocarcinoma
Authors: Krishnan Ravindran, Brandon M Zsigray, Michael P Wemhoff, John D Spencer, Ewa Borys, Chirag R Patel, Anand V Germanwala
Journal: Case Rep Neurol Med (2019)
MeSH terms: Case Reports

Background:
Pituitary metastasis of cervical adenocarcinoma is an exceedingly rare phenomenon.
Case description:
The authors present a case of a 66-year-old female with cervical adenocarcinoma who was discovered to have a rapidly growing intrasellar mass in the work-up of adrenal insufficiency and hypothyroidism. The patient underwent subsequent endoscopic endonasal subtotal resection of the mass. Histopathological analysis of the resected lesion demonstrated features consistent with metastatic mucinous adenocarcinoma of the cervix. While initially neurologically asymptomatic following surgery, the patient developed an oculomotor nerve palsy several weeks following surgical debulking, at which time neuroimaging revealed marked regrowth and suprasellar extension of the metastatic lesion.
Conclusions:
While metastatic cervical adenocarcinoma to the sella is rare, it should be considered in the differential based on the history of the patient.
Sentinel lymph node biopsy in porocarcinoma: A case reports
Authors: Simona Reina, Denise Palombo, Alexandru Boscaneanu, Nicola Solari, Sergio Bertoglio, Luca Valle, Ferdinando Cafiero
Journal: Int J Surg Case Rep (2018)
Keywords: eccrine carcinomas, malignant skin lesions, porocarcinoma, sentinel node biopsy

Introduction:
Eccrine porocarcinoma (EPC) is a slow-growing carcinoma arising from the eccrine sweat glands. Based on its clinical presentation it can be confused with malignant and benign skin lesions, both. Histological examination is essential to formulate a correct diagnosis. Surgical excision with clear margins is the standard therapeutic approach while the role of sentinel lymph node biopsy (SNLB) remains controversial.
Case presentation:
The Authors report two cases of EPC of the lower limbs occurred in two women. Patients were treated by wide surgical excision of the lesion and SNLB. 6 months follow-up was disease free for both patients.
Conclusion:
Although a rare cutaneous tumor, EPC has to be taken into account in the differential diagnosis of malignant skin lesions because of its possible loco-regional aggressiveness and related morbidity. Among the available treatment options, surgical excision is considered the standard approach whereas the role of SNLB is controversial although the Authors discuss a possible usefulness for staging and diagnosis.
Long-standing iron-deficiency anemia in an atypical celiac disease - a case report
Authors: I Dina, C Iacobescu, C Vrabie, S Omer
Journal: J Med Life (2014)
Keywords: anemia, diarrhea, gluten intolerance, young
MeSH terms: Anemia, Iron-Deficiency / complications, Celiac Disease / complications, Case Reports, Adult, CD3 Complex / metabolism, CD8 Antigens / metabolism, Celiac Disease / pathology, Endoscopy, Gastrointestinal, Female, Humans, Immunohistochemistry, T-Lymphocytes / pathology, CD3 Complex, CD8 Antigens

Celiac disease is a complex disorder characterized by digestive symptoms as well as extraintestinal manifestations, sometimes difficult to diagnose. Commonly described as a disease of childhood, adult celiac disease is a well known entity that should be taken into the differential diagnosis of a chronic diarrhea or of a malabsorption syndrome. The pathogenesis encompasses an autoimmune pathway that acts on a genetic background. The mucosa of the small intestine became damaged in reponse to foods that contain gluten in subjects with genetic susceptibility. The clinical presentation is variable, ranging from typical gastrointestinal symptoms to extradigestive and systemic manifestations. The simple withdrawal of the dietary gluten results in clinical improvement and healing of the intestinal mucosa. We report the case of an young women diagnosed with celiac disease after 7 years of iron deficiency anemia without a clear etiology.
Cecal lipoma presenting as acute intestinal obstruction in an elderly woman: a case report
Authors: Miltiades Kastanakis, Dimitrios Anyfantakis, Emmanouil K Symvoulakis, Nikolaos Katsougris, Alexandros Papadomichelakis, Ioannis Kokkinos, George Petrakis, Emmanouil Bobolakis
Journal: Case Rep Surg (2013)

Colonic lipomas are rare nonepithelial tumors that are usually detected incidentally during surgery or colonoscopy. Although lipomas generally remain asymptomatic, when they exceed 2 cm of diameter they may cause abdominal pain, obstruction, or intussusception. Here we present a case of an elderly woman referred by her general practitioner to a general hospital of Crete because of acute abdominal pain along with signs of intestinal obstruction and a positive history of appetite loss. Abdominal computed tomography was performed. To marginalise the risk of malignancy, a right hemicolectomy was performed. Histopathological examination of the resected specimen confirmed the diagnosis of cecal lipoma.
A case report of human immunodeficiency virus-associated anaplastic lymphoma kinase protein-negative anaplastic large cell lymphoma
Authors: Hiroaki Taniai, Norihiro Furusyo, Masayuki Murata, Fujiko Mitsumoto, Motohiro Shimizu, Kazuhiro Toyoda, Eiichi Ogawa, Mosaburo Kainuma, Kyoko Okada, Jun Hayashi
Journal: Springerplus (2013)
Keywords: anaplastic large cell lymphoma, anaplastic lymphoma kinase, human immunodeficiency virus

Human immunodeficiency virus (HIV)-associated anaplastic large cell lymphoma (ALCL) is not so common, and anaplastic lymphoma kinase protein (ALK)-negative ALCL is rare and has a low survival rate. We report a case of a 31-year-old Japanese man diagnosed with HIV-associated ALK-negative ALCL who presented with long-lasting fever of unknown origin. The diagnosis was based on a full work-up that included inguinal lymph-node biopsy. Eight-cycle chemotherapy that included cyclophosphamide, doxorubicin, vincristine, and prednisone in addition to antiretroviral therapy for HIV infection provided a complete remission of his ALCL and over 5-year survival for him.
Spontaneous gastrocnemius muscle haematoma formation in a patient with alcoholic liver disease
Authors: Ndawapeka Tulonga Nhinda, Innocent Lule Segamwenge, Twitileni Nampweya, Chrizelda Engels
Journal: Pan Afr Med J (2020)
Keywords: alcoholic hepatitis, liver cirrhosis, muscle haematoma
MeSH terms: Antifibrinolytic Agents / administration & dosage, Hematoma / etiology, Liver Cirrhosis, Alcoholic / complications, Case Reports, Adult, Hematoma / drug therapy, Humans, Male, Muscle, Skeletal / pathology, Antifibrinolytic Agents

Advanced liver disease is associated with several haemostatic alterations which can lead to either thrombosis or bleeding complications. Spontaneous muscle haematomas although a rare complication of liver cirrhosis is increasingly being described in the literature and hyperfibrinolysis is an emerging plausible pathophysiological mechanism. We describe a patient who presented with a life threatening spontaneous haematoma in his gastrocnemius muscle that required treatment with antifibrinolytic therapy to control further bleeding.
Case Report: Emphysematous Cystitis and Pyelonephritis Induced by Uterine Prolapse in a Subject With Untreated Diabetes Mellitus
Authors: Hideyuki Iwamoto, Takatoshi Anno, Haruka Takenouchi, Kaio Takahashi, Megumi Horiya, Yukiko Kimura, Fumiko Kawasaki, Kohei Kaku, Koichi Tomoda, Shinya Uehara, Hideaki Kaneto
Journal: Front Med (Lausanne) (2021)
Keywords: diabetes mellitus, emphysematous cystitis, emphysematous pyelonephritis, obstructive uropathy, uterine prolapse
MeSH terms: Case Reports

Type 2 diabetes mellitus (T2DM) is often accompanied by a lot of complications due to chronic hyperglycemia and inflammation. Emphysematous cystitis and pyelonephritis are rare types of urinary tract infections and are often complicated with DM. Herein, we report a case of emphysematous cystitis and pyelonephritis complicated with untreated DM. In addition, this case was very rare and interesting in that her emphysematous cystitis and pyelonephritis were induced by severe uterine prolapse, obstructive uropathy and urination disorders. Both uterine prolapse and DM should be appropriately treated because both can lead to the development of emphysematous cystitis and pyelonephritis.
Mid-Left Ventricular Ballooning Variant Takotsubo Syndrome Induced by Treadmill Exercise Stress Testing
Authors: Gregg Cantor, Getu Teressa
Journal: Case Rep Cardiol (2018)
MeSH terms: Case Reports

Stress-induced cardiomyopathy, also known as takotsubo cardiomyopathy, presents similar to a myocardial infarction after a physical or emotional stressor but without any evidence of obstructive coronary artery disease. Different patterns of myocardial involvement and several triggering events have been reported, but classically this condition is characterized by a stress-induced transient left ventricular apical systolic dysfunction. We describe a case of treadmill exercise stress testing-triggered variant of takotsubo cardiomyopathy with mid-left ventricular hypokinesis.
Bipolar affective disorder and Parkinson's disease
Authors: Birk Engmann
Journal: Case Rep Med (2011)
MeSH terms: Case Reports

Little is known about comorbidities of bipolar disorder such as Parkinson's disease. A case history and a literature survey indicate that bipolar disorder is linked with or influences Parkinson's disease and vice versa. Underlying mechanisms are poorly understood, and, more importantly, no treatment options are established in such double diagnoses. The few data in comorbid Parkinson cases seem to point to a rapid cycling pattern of bipolar symptoms. With regard to therapeutic intervention, the literature supports pramipexole for treatment of both Parkinson and depressive symptoms in bipolar depression. Lithium, the mood stabilizer of choice for treating manic states, is problematical for use in Parkinson patients because of its side effects. Valproate might be an alternative, especially for treatment of rapid cycling.
A BRAF V600E Mutation in RET-Negative Medullary Thyroid Cancer
Authors: Richard J Robbins, Jessica S Thomas, Patricia Mejia Osuna, Jawairia Shakil
Journal: Case Rep Endocrinol (2020)
MeSH terms: Case Reports

We report the case of a woman with a sporadic medullary thyroid carcinoma. Genomic analysis found that her tumor did not contain any common RET mutations but did harbor a BRAF V600E mutation. Only one other well-confirmed example of the BRAF V600E mutation has been reported in an MTC patient. We conclude that this common BRAF mutation may independently drive neoplastic transformation of human parafollicular C cells.
Surgical Treatment of Radiation-Induced Late-Onset Scalp Wound in Patients Who Underwent Brain Tumor Surgery: Lessons from a Case Series
Authors: Jinhyun Kim, Kyung Chan Ahn, Hak Chang, Jae Hoon Jeong, Changsik John Pak, Byung Jun Kim
Journal: Biomed Res Int (2022)
MeSH terms: Brain Neoplasms / radiotherapy, Brain Neoplasms / surgery, Craniocerebral Trauma / surgery, Plastic Surgery Procedures / methods, Radiation Injuries / etiology, Radiation Injuries / surgery, Humans, Postoperative Complications / surgery, Retrospective Studies, Scalp / surgery, Surgical Flaps / surgery

Objective:
The management of late-onset scalp wounds following irradiation is troublesome, especially in patients with a surgical history of intracranial neoplasms. It, insidiously, starts with wound dehiscence or discharge and never heals spontaneously without appropriate surgical treatment. Nevertheless, definite treatment guidelines have not yet been established. Here, we present our clinical experience with radiation-induced scalp wounds and suggest a surgical principle for their treatment. Patients and Methods. The medical records of 13 patients with brain tumors, who were treated for intractable scalp wounds after irradiation between January 2000 and August 2015, were retrospectively reviewed. All the patients underwent a craniotomy for brain tumor resection. Surgical treatment for a late-onset scalp wound was decided based on the "reconstructive ladder" and according to the status of bone flap and scalp tissue. The patients' clinical characteristics and information regarding irradiation, surgery, and postoperative complications were recorded.
Results:
Scalp wounds developed 4.4 years, on average, after the completion of irradiation. Revision operations were performed an average of 2.3 times, and 6 patients (46%) required more than 2 operations. The bone flap was removed in 11 patients (84.6%) to achieve complete wound healing. Among them, 3 patients underwent a cranioplasty using artificial materials, but 2 patients underwent removal due to recurrent wound problems.
Conclusions:
Postirradiation scalp wounds are difficult to treat and have a high risk of recurrence. If osteoradionecrosis is suspected, the bone flap should be removed. It is important to debride unhealthy tissues aggressively and cover defects with robust tissue.
Case Report: Ramipril and microscopic colitis; a necessary tool of cardiologists can rarely be devastating for patients
Authors: Saad Hasan, Haseeb Ur Rahman, Stephen Hutchison
Journal: F1000Res (2020)
Keywords: ramipril, bowel incontinence, diarrhoea, microscopic colitis
MeSH terms: Case Reports

Angiotensin converting enzyme inhibitors could lead to severe diarrhoea related to microscopic colitis. Few of such cases have been reported before and this serious problem, from a widely used class of drugs in hypertension and heart failure, needs to be more recognised. We describe the case of collagenous colitis related to ramipril use in the following case report. A 74-year-old farmer who had a history of triple vessel coronary artery disease was admitted to district general hospital with non-ST elevation myocardial infarction. He had known alcohol-related chronic pancreatitis with chronic diarrhoea as a complication, which was managed with pancreatic enzyme replacement therapy. However, he developed severe worsening of diarrhoea causing bowel incontinence and nocturnal symptoms during his admission to hospital. The explosive and watery nature of diarrhoea with urgency was so troublesome that it delayed coronary revascularisation and lead him to have significant psychological distress and low mood while nocturnal bowel motions meant he was unable to sleep. He was compliant with his pancreatic enzyme replacement therapy during this period. Infective causes were ruled out by stool microbiology examination and coeliac disease by oesophagogastroscopy and biopsy. It was noticed that he was recently prescribed ramipril that was later stopped as a possible diarrhoea trigger. Diarrhoea started settling immediately and resolved to his baseline within a week. A colonoscopy was performed in the meantime and biopsies demonstrated microscopic colitis (MC). He did not tolerate budesonide well so was stopped. However, a follow-up colonoscopy with biopsy in two months showed resolution of MC.
Henoch-Schönlein Purpura with Adalimumab Therapy for Ulcerative Colitis: A Case Report and Review of the Literature
Authors: Joseph J LaConti, Jean A Donet, Jeong Hee Cho-Vega, Daniel A Sussman, Dana Ascherman, Amar R Deshpande
Journal: Case Rep Rheumatol (2016)

Tumor necrosis factor-α (TNFα) inhibitor therapy has signified an important milestone in the fight against many rheumatological disorders and inflammatory bowel disease (IBD). Cutaneous adverse events caused by this class of medications are well known but relatively uncommon. Most reactions are mild and rarely warrant treatment withdrawal. Henoch-Schönlein purpura (HSP) is a disease with cutaneous vasculitis, arthritis, and gastrointestinal and renal involvement that is usually seen in children, though the worst complications are typically seen in adults. We present a case of HSP complicating adalimumab treatment in a patient with ulcerative colitis who had achieved endoscopic remission. We review similar cases reported in the literature and discuss the consequences of these autoimmune diseases.
Metacognitive Therapy for Alcohol Use Disorder: A Systematic Case Series
Authors: Gabriele Caselli, Francesca Martino, Marcantonio M Spada, Adrian Wells
Journal: Front Psychol (2018)
Keywords: addiction, alcohol use disorder, metacognition, metacognitive therapy, outcome, treatment

Alcohol Use Disorder (AUD) is a debilitating condition with serious adverse effects on health and psycho-social functioning. The most effective psychological treatments for AUD show moderate efficacy and return to dysregulated alcohol use after treatment is still common. The aim of the present study was to evaluate Metacognitive Therapy (MCT) as applied to AUD. Five patients were treated using a non-concurrent multiple baseline design with follow-up at 3- and 6-months time points. Each patient received 12 one-hour sessions of MCT. Following MCT all patients demonstrated large and clinically meaningful reductions in weekly alcohol use and number of binge drinking episodes that were upheld at follow-up in almost all cases. Metacognitive beliefs, as secondary outcome, also changed substantially. The findings from this study offer preliminary evidence of positive effects associated with MCT in AUD and support the need for a definitive trial of MCT in addictive behaviors.
Team dynamics and clinician's experience influence decision-making during Upper-GI multidisciplinary team meetings: A multiple case study
Authors: J C H B M Luijten, M J Westerman, G A P Nieuwenhuijzen, J E W Walraven, M N Sosef, L V Beerepoot, R van Hillegersberg, K Muller, R Hoekstra, J J G H M Bergman, P D Siersema, H W M van Laarhoven, C Rosman, L Brom, P A J Vissers, R H A Verhoeven
Journal: Front Oncol (2022)
Keywords: clinicians, experience, multidisciplinary team meeting (mdt), team dynamics, upper-gi cancer

Background:
The probability of undergoing treatment with curative intent for esophagogastric cancer has been shown to vary considerately between hospitals of diagnosis. Little is known about the factors that attribute to this variation. Since clinical decision making (CDM) partially takes place during an MDTM, the aim of this qualitative study was to assess clinician's perspectives regarding facilitators and barriers associated with CDM during MDTM, and second, to identify factors associated with CDM during an MDTM that may potentially explain differences in hospital practice.
Methods:
A multiple case study design was conducted. The thematic content analysis of this qualitative study, focused on 16 MDTM observations, 30 semi-structured interviews with clinicians and seven focus groups with clinicians to complement the collected data. Interviews were transcribed ad verbatim and coded.
Results:
Factors regarding team dynamics that were raised as aspects attributing to CDM were clinician's personal characteristics such as ambition and the intention to be innovative. Clinician's convictions regarding a certain treatment and its outcomes and previous experiences with treatment outcomes, and team dynamics within the MDTM influenced CDM. In addition, a continuum was illustrated. At one end of the continuum, teams tended to be more conservative, following the guidelines more strictly, versus the opposite in which hospitals tended towards a more invasive approach maximizing the probability of curation.
Conclusion:
This study contributes to the awareness that variation in team dynamics influences CDM during an MDTM.