OpenMed/multicare-articles huggingface dataset:
A Rare Case of Gastrointestinal Tract Foreign Body; Glassy Stomach
Authors: Mohsen Ebrahimi, Jafar Malmir, Azadeh Mahmoudi-Gharaee, Mahdi Foroughian
Journal: Emerg (Tehran) (2017)
Keywords: foreign bodies, case management, emergencies, gastrointestinal tract, glass
MeSH terms: Case Reports

Ingestion of foreign bodies is common and conservative treatment can eliminated most particlesfrom the gastrointestinal tractunless peritoneal signs appear. A 22-year-old man presented to emergency department who had ingested glass particles of a crushed beveragebottle.Hecomplained ofepigastric and periumbilical pain. Physical examination did not revealany peritoneal signs. Abdominal X-ray showed stomach full of small glass particles. Conservative treatment, without any surgical intervention,resulted insafely eliminating glass particlesin this patient.
Rapid Progression to Complete Paraplegia After Electroacupuncture in a Patient With Spinal Dural Arteriovenous Fistula: A Case Report
Authors: Ki-Hoon Park, Chang-Hoon Jeon, Nam-Su Chung, Han-Dong Lee
Journal: Front Surg (2021)
Keywords: electroacupuncture, neurologic deficits, paraplegia, spinal dural arteriovenous fistula, spinal vascular malformation
MeSH terms: Case Reports

Spinal dural arteriovenous fistula (SDAVF) usually has an insidious clinical course, but 5-15% of the cases have acute exacerbations. In some cases, there is an abrupt progression to paraplegia following an epidural injection or anesthesia. Electroacupuncture is a form of acupuncture that applies a small electrical current to needles inserted at specific points in the body. It is widely used for its analgesic effect on back pain. In this study, we report a rare case of SDAVF in which the symptoms of a patient worsened rapidly to complete paraplegia within a few hours after applying electroacupuncture to his back. A 49-year-old man had rapid progression to complete paraplegia within a few hours of electroacupuncture on his back. MRI showed SDAVF and worsening of cord signal change. An emergency operation was performed to ligate the SDAVF. The patient was able to walk 1 month post-operatively. Most of the neurological deficits had disappeared by 1 year post-operatively, with normalization of MRI. Our case emphasizes that SDAVF patients should be careful when exposed to any circumstances that might affect the circulation around the dural arteriovenous fistula, such as electroacupuncture. Patients should also be warned in advance about the possibility of rapid exacerbation of neurological symptoms. Regardless of the severity of the neurological symptoms, immediate treatment is essential for recovery and a better outcome.
Surgery Versus ATMPs: An Example From Ophthalmology
Authors: Federica M Magrelli, Alessia Merra, Graziella Pellegrini
Journal: Front Bioeng Biotechnol (2020)
Keywords: atmp, cost of treatment, ophthalmology, public–private health care, surgery
MeSH terms: Review

Advanced therapy medicinal products (ATMPs) are the new frontier of medicine. Advanced therapy medicinal products are set out to satisfy unmet medical needs and provide new innovative, cutting-edge therapies for serious or life-threatening diseases, thus providing new therapeutic options for people with few or no possibility of treatment. They are divided into four groups including gene therapy medicinal products, cell-based therapy medicinal products, tissue-engineered products, and combined ATMPs, which in Europe refer to products that incorporate one or more medical devices with any of the previously mentioned ATMPs as part of the advanced medicine product (AIFA, 2017; Ten Ham et al., 2018). Advanced therapy medicinal products can potentially have long-term benefits, thus bringing a long-lasting positive impact on patient health. Advanced therapy medicinal product therapies are often administered just once or twice, which gives patients the possibility to heal quickly compared to traditional therapies. They also provide a long-term saving opportunity, both in terms of costs of treatments and procedures that are no longer necessary and in terms of quality of life and productivity. The resolution of the patient's illness has a monetary impact on the patient, the patient's caretakers, and especially on the society (Alliance for Regenerative Medicine, 2019). The aim of this paper was to provide an overview on the use of ATMPs approved in Europe, with a focus on blindness and visual impairment and the related economic burden. In this case study, the effective cost of a blind patient in different European countries was compared after treatment with ATMPs or traditional therapies, focusing on visual impairment caused by corneal opacity. Our evaluation includes an overview of the global economic impact of the two types of therapies on the society. We estimated direct healthcare costs, direct non-healthcare costs, and labor productivity losses, to include costs on healthcare, services, patients, their families and for the society in general. We could conclude that the costs of the two therapeutic approaches are comparable.
Pneumatosis intestinalis in oncologic patients: when should the radiologist not be afraid?
Authors: Claudia Sassi, Milena Pasquali, Giancarlo Facchini, Alberto Bazzocchi, Giuseppe Battista
Journal: BJR Case Rep (2016)
MeSH terms: Case Reports

Pneumatosis intestinalis (PI) is a term used to describe the presence of submucosal and subserosal gas in the gastrointestinal tract. It can occur as a primary disease or, more commonly, secondary to various other causes ranging from benign conditions to fulminant diseases. We present four cases of benign PI in patients being treated for various types of cancer. They had no abdominal symptoms, the physical examination was normal and PI was an isolated incidental CT finding in the absence of other signs of bowel wall distress. A conservative non-surgical approach was advocated and follow-up imaging documented the resolution of PI. The radiologist should recognize this condition in order to help the oncologist to interpret its clinical significance and avoid unnecessary surgical procedures.
The Use of Miswak as Toothbrush for Orthodontic Patient
Authors: Khoirulzariah Ismail
Journal: Case Rep Dent (2016)

This case report presents a patient who is undergoing orthodontic treatment with upper and lower fixed appliance. An interesting point on this case is that the patient only uses Miswak as her oral hygiene tool due to her religious belief. The oral hygiene protocol was allowed and her oral health was closely monitored throughout her orthodontic treatment.
Acute disseminated encephalomyelitis following the COVID-19 vaccine Ad26.COV2.S, a case report
Authors: Stefan Gustavsen, Mette Maria Nordling, Arkadiusz Weglewski
Journal: Bull Natl Res Cent (2023)
Keywords: adem, acute disseminated encephalomyelitis, ad26cov2s, covid-19, johnson & johnson, sars-cov-2, vaccine
MeSH terms: Case Reports

Background:
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has been leading to dramatic health, social and economic problems around the world. It was necessary to introduce worldwide vaccination program against SARS-CoV-2 virus. Vaccination of billions of people around the world leads to many questions about risk of vaccines and possible side effects. It is well known that acute disseminated encephalomyelitis (ADEM) is a rare, but possible complication of vaccines. Previously, cases of ADEM following various COVID-19 vaccines, including the vaccines from AstraZenica, Pfizer, Sputnik V, SinoVac, Moderna, Sinopharm, have been described. In this case report, we present the first documented case of ADEM following the COVID-19 vaccine Ad26.COV2.S from Johnson & Johnson.
Case presentation:
We present the case of a 31-year-old female with gradually progression of right-sided weakness and numbness during a three-week period. Four weeks prior to symptom onset, the patient received the single-dose SARS-CoV-2 vaccine Ad26.COV2.S. Neuroimaging revealed five large juxtacortical T2 FLAIR hyperintense lesions with incomplete contrast enhancement on post-contrast T1 images located supratentorial: one in the right cerebral hemisphere and four in left cerebral hemisphere. The patient was followed up for four months. Symptom debut, clinical picture and MRI were typical for ADEM and the patient completely recovered after high dose intravenous methylprednisolone treatment.
Conclusions:
This is, to the best of our knowledge, the first case report of ADEM following the COVID-19 vaccine Ad26.COV2.S. This case illustrates, although ADEM is a rare complication following SARS-CoV-2 vaccines, the necessity of maintaining a vaccine safety monitoring system to identify patients at high risk from developing severe complications from the vaccines.
A Neonatal Case With Perinatal Lethal Gaucher Disease Associated With Missense G234E and H413P Heterozygous Mutations
Authors: Meili Wei, Aiqin Han, Liping Wei, Liji Ma
Journal: Front Pediatr (2019)
Keywords: convulsions, hepatosplenomegaly, ichthyosis, premature neonate, thrombocytopenia
MeSH terms: Case Reports

Perinatal lethal Gaucher disease (PLGD), a particular and serious form of type 2 Gaucher disease (GD), often causes lethality in utero or death within hours after birth. The typical clinical manifestations include non-immune hydrops fetalis (NIHF), premature birth, fetal growth restriction, fetal intrauterine death, or neonatal distress and rapid death after birth. Here, we present a premature neonate with GD whose main clinical manifestations included intrauterine growth retardation, anasarca, facial dysmorphia, ichthyosis, respiratory distress, hepatosplenomegaly, joint contractures, myoclonus, refractory thrombocytopenia, anemia, elevated levels of liver enzymes, bile acid and direct bilirubin, cholestasis, pulmonary hypoplasia, intracranial hemorrhage, and abnormal electroencephalogram. The activity of β- glucocerebrosidase was 0 in the peripheral white blood cells of the neonate. The sequencing analysis identified the presence of missense G234E and H413P heterozygous mutations in glucerebrosidase (GBA) exon 7 and 10, with the latter first observed to be associated with PLGD. This infant died at 73 days of age.
Relapsing polychondritis following alopecia areata
Authors: John C Starr, Nidhika Taneja, George W Brasher
Journal: Case Rep Med (2010)
MeSH terms: Case Reports

A case of alopecia areata followed by relapsing polychondritis is presented. Similar cases from the literature are reviewed and speculation about the relationship of these diseases is offered. Although the occurrence of these diseases together could be coincidental, an association seems immunologically plausible. Thus, relapsing polychondritis might be an unusual systemic manifestation of alopecia areata.
MRI and FDG PET/CT Findings for Borderline Brenner Tumor of the Ovary: A Case Report and Literature Review
Authors: Hiroki Matsutani, Go Nakai, Takashi Yamada, Kazuhiro Yamamoto, Masahide Ohmichi, Keigo Osuga
Journal: Case Rep Obstet Gynecol (2020)
MeSH terms: Case Reports

The imaging features of borderline Brenner tumor (BT) of the ovary are very limited, especially regarding apparent diffusion coefficient (ADC) value and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET)/CT. We report a case of borderline BT in a 54-year-old woman with diffusion-weighted imaging (DWI) and FDG-PET/CT findings. Furthermore, ADC values and maximum standardized uptake value (SUV max) in the present case were compared with those of an additional 7 cases of benign BT in this institution in addition to literature reviews. Magnetic resonance imaging (MRI) revealed a pelvic unilocular cystic tumor with two solid components. The solid mass showing a low signal intensity (SI) in T2-weighted images (T2WI) and DWI was diagnosed as a benign BT histologically. The papillary tumor adjacent to the solid mass showing intermediate SI in T2WIs and high SI on DWI was a borderline BT. The mean ADC value (×10-3 mm2/s) of benign BTs (n = 7) and benign component in this case (n = 1) was 1.13, and the range of ADC values was broad (0.51-1.8). While, the ADC value of borderline Brenner component in this case was 1.10. The mean SUVmax of the benign BTs (n = 4) demonstrated mild FDG uptakes (2.3, range 1.9-2.6) in contrast with moderate FDG uptake (SUVmax: 5.8) of borderline Brenner component in this case and high FDG uptake (SUVmax: 9.6) of a malignant BT in a previous report. ADC values for the solid component of BTs are not useful for differentiating benign from malignant or borderline components, whereas PET/CT could be useful.
Multiple Culprit Coronary Artery Thrombosis in a Patient with Coronary Ectasia
Authors: Bruno da Silva Matte, Gustavo Neves de Araujo, Felipe Homem Valle, Ana Maria Rocha Krepsky
Journal: Case Rep Cardiol (2018)
MeSH terms: Case Reports

We here report a case of ST-elevation myocardial infarction (STEMI) due to simultaneous acute coronary artery occlusions of two major coronary arteries in a patient with coronary ectasia. The patient had been previously submitted to percutaneous coronary angioplasty with bare metal stent implantation in both culprit vessels. Very late stent thrombosis could be the cause of the first occlusion, triggering the event in the other vessel. In addition, concomitant embolic sources were not identified. Although routine aspiration thrombectomy in STEMI was not proven to be beneficial in randomized clinical trials, it was of great value in this case. We also discuss the relation between coronary ectasia, chronic inflammatory status, and increased platelet activity which may have caused plaque disruption in another already vulnerable vessel.
Diabetic-ketoacidosis in a nine-year-old child with homozygous sickle cell anaemia: a rare case report
Authors: Nuraddeen Ibrahim, Abubakar Sani Lugga, Olayinka Rasheed Ibrahim
Journal: Pan Afr Med J (2019)
Keywords: type i diabetes mellitus, child, diabetic ketoacidosis, mesenteric crisis, sickle cell anaemia
MeSH terms: Anemia, Sickle Cell / physiopathology, Diabetes Mellitus, Type 1 / complications, Diabetic Ketoacidosis / diagnosis, Case Reports, Child, Diabetic Ketoacidosis / physiopathology, Diabetic Ketoacidosis / therapy, Humans, Hyperglycemia / diagnosis, Hyperglycemia / etiology, Ketosis / diagnosis, Ketosis / etiology, Male

Sickle cell anaemia (SCA) and type 1 diabetes mellitus (type 1 DM) are chronic medical conditions whose co-existence is uncommon in childhood. Furthermore, complications of SCA such as mesenteric crisis typically present with abdominal pain, which is also common in children with diabetic ketoacidosis (DKA) and this may possess diagnostic challenge. Herewith in, we report a rare case of a nine-year-old child with homozygous sickle cell anaemia, who presented with features of mesenteric crisis and diabetic ketoacidosis. The DKA was diagnosed based on the presence of hyperglycaemia (32.2 mmol/L), ketonaemia (4.6 mmol/L) and acidosis (11.6 mmol/L). The fluids deficit was corrected over 24 hours, with improvement in the vaso-occlusive crises (VOC) without precipitating cerebral oedema.
Pulmonary Kaposi sarcoma in a human immunodeficiency virus - infected woman: a case report
Authors: Rafael Ferracini Cabral, Edson Marchiori, Tatiana Chinem Takayasu, Fernanda Caseira Cabral, Raquel Ribeiro Batista, Gláucia Zanetti
Journal: Cases J (2009)

Approximately 90% to 95% of Kaposi sarcoma cases occur in human immunodeficiency virus - infected homosexual and bisexual men. Pulmonary Kaposi sarcoma is uncommon in women, and rarely considered as a potential cause of diffuse lung disease in women with acquired immunodeficiency syndrome. The disease is usually mistaken clinically for pulmonary infection. A 32-year-old woman was admitted with a 2-month history of dyspnea, evening fever, hemoptysis, weight loss, and generalized adenomegaly. Physical examination showed erythematous macules in the lower limbs. Skin and open lung biopsy demonstrated Kaposi sarcoma. Computerized tomography demonstrated peribronchovascular interstitial thickening. Although uncommon, pulmonary Kaposi sarcoma should be considered in the differential diagnosis of diffuse lung disease in women with AIDS.
Case Report: Thrombotic-Thrombocytopenic Purpura Following Ipilimumab and Nivolumab Combination Immunotherapy for Metastatic Melanoma
Authors: W J Mullally, F J Cooke, I M Crosbie, S Kumar, V E Abernethy, E J Jordan, M O'Connor, A M Horgan, R Landers, J Naidoo, P M Calvert
Journal: Front Immunol (2022)
Keywords: combination checkpoint inhibitors, hematological adverse events, ipilimumab, nivolumab, thrombotic-thrombocytopenic purpura
MeSH terms: Melanoma / drug therapy, Neoplasms, Second Primary, Purpura, Thrombocytopenic, Idiopathic, Purpura, Thrombotic Thrombocytopenic / diagnosis, Case Reports, Humans, Immunologic Factors, Immunotherapy, Ipilimumab / adverse effects, Male, Nivolumab / adverse effects, Immunologic Factors, Ipilimumab, Nivolumab

A man in his early 50s presented with small bowel obstruction, requiring emergency laparoscopic small bowel resection for the metastatic melanoma of the jejunum with no identifiable primary lesion. One week after his first treatment with ipilimumab and nivolumab, he presented with diffuse abdominal pain, constipation, and fatigue. A computerized tomography scan did not identify a cause for his symptoms. This was rapidly followed by thrombocytopenia on day 11 and then anemia. He commenced intravenous corticosteroids for a suspected diagnosis of immune-related thrombocytopenia. On day 15, a generalized onset motor seizure occurred, and despite plasmapheresis later that day, the patient died from fatal immune-related thrombotic thrombocytopenic purpura (TTP). This was confirmed with suppressed ADAMTS13 (<5%) testing on day 14. Immune-related TTP is a rare and, in this case, fatal immune- related adverse event. Further studies are required to identify additional immunosuppressive management for immune-related TTP.
Tongue Tied after Shoulder Surgery: A Case Series and Literature Review
Authors: Molly B Kraus, Rachel B Cain, David M Rosenfeld, Renee E Caswell, Michael L Hinni, Michael J Molloy, Terrence L Trentman
Journal: Case Rep Anesthesiol (2019)
MeSH terms: Case Reports

This article presents three cases of cranial nerve palsy following shoulder surgery with general anesthesia in the beach chair position. All patients underwent preoperative ultrasound-guided interscalene nerve block. Two cases of postoperative hypoglossal and one case of combined hypoglossal and recurrent laryngeal nerve palsies (Tapia's syndrome) were identified. Through this case series, we provide a literature review identifying postoperative cranial nerve palsies in addition to the discussion of possible etiologies. We suggest that intraoperative patient positioning and/or airway instrumentation is most likely causative. We conclude that the beach chair position is a risk factor for postoperative hypoglossal nerve palsy and Tapia's syndrome.
A Case of Invasive Gastrointestinal Mycotypha Infection in a Patient with Neutropenia
Authors: Polina Trachuk, Wendy A Szymczak, Peter Muscarella, Uzma N Sarwar
Journal: Case Rep Infect Dis (2018)
MeSH terms: Case Reports

Gastrointestinal mucormycosis is a rare life-threatening infection to which neutropenic patients are especially vulnerable. Mycotypha microspora is a mucormycete that has not been described as a human pathogen. We discuss the successful eradication of gastrointestinal Mycotypha microspora in a neutropenic patient with simultaneous pulmonary Aspergillus fumigatus infection.
Duplication of the Pituitary Gland (DPG)-Plus Syndrome Associated With Midline Anomalies and Precocious Puberty: A Case Report and Review of the Literature
Authors: Giovanni Prezioso, Maddalena Petraroli, Michela Bergonzani, Giusy Davino, Marialuisa Labate, Francesca Ormitti, Marilena Anghinoni, Enrico Sesenna, Susanna Esposito
Journal: Front Endocrinol (Lausanne) (2021)
Keywords: craniofacial abnormalities, midline malformations, pediatric endocrinology, pituitary, precocious puberty
MeSH terms: Abnormalities, Multiple / diagnostic imaging, Abnormalities, Multiple / drug therapy, Abnormalities, Multiple / surgery, Craniofacial Abnormalities / diagnostic imaging, Craniofacial Abnormalities / drug therapy, Craniofacial Abnormalities / surgery, Pituitary Diseases / diagnostic imaging, Pituitary Diseases / drug therapy, Pituitary Diseases / surgery, Puberty, Precocious / diagnostic imaging, Puberty, Precocious / drug therapy, Puberty, Precocious / surgery, Case Reports, Research Support, Non-U.S. Gov't, Review, Child, Female, Humans, Magnetic Resonance Imaging, Pituitary Gland / abnormalities, Pituitary Gland / diagnostic imaging, Syndrome, Tomography, X-Ray Computed, Triptorelin Pamoate / therapeutic use, Triptorelin Pamoate

Duplication of the pituitary gland (DPG)-plus syndrome is a very rare developmental disorder with few cases described in the literature and characterized by multiple midline and central nervous system malformations. The hypothalamus and hypophysis involvement may be clinically associated with endocrine abnormalities. A 5.9-year-old female child was admitted to our Clinic for premature thelarche and acceleration of growth. DPG-plus syndrome with paired infundibula and pituitary glands was diagnosed after birth, when she appeared small for gestational age and she presented with lingual hypoplasia, cleft palate, right choanal stenosis, nasopharyngeal teratoma, and facial dysmorphisms. Neuroimaging revealed a duplication of the infundibula, the pituitary gland, and the dens of the epistropheus despite surgical removal of a rhino-pharyngeal mass performed at the age of two months. An array-CGH revealed a 2p12 deletion. At our evaluation, bone age assessment resulted advanced and initial pubertal activation was confirmed by Gonadotropin-Releasing Hormone stimulation test. Hormonal suppression treatment was started with satisfactory results. This case shows that DPG-plus syndrome must be considered in presence of midline and craniofacial malformations and endocrinological evaluations should be performed for the prompt and appropriate management of pubertal anomalies.
Unusual cup reconstruction of massive acetabulum perforation in neglected femoral neck osteoporotic fracture: A case report
Authors: Franky Hartono, Karina Besinga, Daniel Petrus Marpaung, Andrew B Budisantoso, Tessi Ananditya
Journal: Int J Surg Case Rep (2019)
Keywords: case report, massive acetabulum perforation, neglected femoral neck fracture, osteoporotic bone

Introduction:
Uncemented total hip for neglected nonunion femoral neck fracture hopefully could minimize the post operative complications. Nevertheless, due to plasticity of the brittle osteoporotic bone, unexpected fracture may occur. We presented an unusual reconstruction of acetabulum which was accidently perforated during uncemented cup insertion.
Presentation of case:
A 76 years old wheelchair bound female showed a nonunion fracture of the right femoral neck due to a fall 7 years ago. She had right hip instability with 5 cm leg shortening. Uncemented total hip replacement was originally planned, however, due to unexpected perforation of the acetabulum, it was ended in total hip after creating a composite layers to fix a cemented cup. Patient was full ambulatory with walker at 4 months. Harris Hip Score at 15 months showed 71.3%, compared with 20.2% before surgery.
Discussion:
The plasticity of the osteoporotic acetabulum floor was the reason why the uncemented cup could not be fixed, instead it caused massive perforation of the floor. The acetabulum reconstruction was done by composite layers made from remaining chondral bone shell, absorbable hemostatic gelatin sponge and cancellous bone of the femoral head, porous collagen matrix and uncemented titanium acetabulum cup fixed with two screws.
Conclusion:
In unexpected acetabulum perforation, the remaining chondral shell of femoral head together with uncemented cup as a cage support and bone cement can be used to reconstruct the acetabulum floor. More stability can be achieved using reconstruction cage with allograft and or metal augments or using a cemented total hip arthroplasty.