OpenMed/multicare-articles huggingface dataset:
Lower lip squamous cell carcinoma: A Vietnamese case report of surgical treatment with reconstruction by local flap
Authors: Hau Xuan Nguyen, Hung Van Nguyen, Hien Xuan Nguyen, Quang Van Le
Journal: Int J Surg Case Rep (2018)
Keywords: local flap, lower lip cancer, reconstruction, squamous cell carcinoma, vietnam

Introduction:
Squamous cell carcinoma (SCC) of lower lip comprises over 25% of oral cancer. Surgical treatment plan for SCC patients includes tumor excision, lymph node dissection and reconstruction.
Case presentation:
A 68-year-old patient was admitted with 1-year history of tumor in his lower lip. Examination revealed a large lower lip tumor with expansion to the upper lip and a 2 cm submental lymph node. Biopsy result of the tumor was SCC and fine needle aspiration result of the lymph node was metastasis SCC. He underwent a complete removal of the lower lip and 1/3 external of the upper lip plus dissection of bilateral cervical lymph node plus reconstruction with local flap. After a 4-hour operation and 14-day hospitalization, patient recovered with flap in excellent condition and without any complications.
Conclusion:
Treatment with tumor excision, lymph node dissection and reconstruction by local flap is primary treatment for patients with lower lip cancer. Choice of reconstruction method depends on various factors, whereas V-Y advancement flap presents dominant advantage in lower lip cancer treatment.
EML4-ALK rearrangement in primary malignant fibrous histiocytoma of the lung treated with alectinib: A case report
Authors: Shuai Zhang, Xuqiang Liao, Jiawei Chen
Journal: Front Oncol (2022)
Keywords: alectinib, case report, lung, malignant fibrous histiocytoma (mfh), treatment
MeSH terms: Case Reports

Primary malignant fibrous histiocytoma of the lung (PMFHL) is extremely rare. It is more common in the right lung and has no specific symptoms. Lymph node metastasis is rare, but hematogenous metastasis is more common. The common metastatic sites are the brain and bone. In this study, a 59-year-old male patient was diagnosed with PMFHL with brain metastasis due to persistent cough and blood in the sputum for the past week. Genetic testing revealed EML4-ALK gene rearrangement (fusion). We first used alectinib in a patient with advanced PMFHL with EML4-ALK gene rearrangement (fusion) accompanied by brain metastasis. The treatment was effective and successfully delayed the development of the disease. Satisfactory results were observed, with an overall survival time of 19 months. Therefore, genetic testing in PMFHL and the choice of treatment plan are important. Local treatment methods, including surgery and radiotherapy, are important when the disease is less advanced. Multidisciplinary discussion is recommended for the best prognosis.
Neoadjuvant Chemotherapy and Appleby Procedure for Pancreatic Acinar Cell Carcinoma: A Case Report
Authors: Masaya Jimbo, Philip M Batista, Jeffrey P Baliff, Charles J Yeo
Journal: Case Rep Pancreat Cancer (2016)
Keywords: appleby procedure, acinar cell carcinoma, neoadjuvant chemotherapy
MeSH terms: Case Reports

Background: Acinar cell carcinoma is a rare form of pancreatic cancer, accounting for 1-2% of all cases of exocrine pancreatic neoplasms in adults. Due to its rarity, no randomized controlled trials have been performed to determine the optimal treatment options. As such, high-quality case reports and case series are needed to help guide clinicians in the management of this deadly disease. Case Presentation: A 56-year-old Caucasian male presenting with abdominal pain and weight loss was diagnosed with stage III acinar cell carcinoma of the pancreatic body with celiac axis involvement. Although initially deemed unresectable, the patient responded favorably to nine cycles of 5-fluorouracil-based neoadjuvant chemotherapy. The tumor was successfully resected through distal pancreatectomy with en bloc splenectomy and en bloc celiac artery resection (Appleby procedure). Final pathology analysis showed negative resection margins and complete chemotherapeutic response within the pancreas, with residual tumor cells detected in only a single peripancreatic lymph node. Conclusion: 5-fluorouracil-based chemotherapy may be a promising option for the neoadjuvant treatment of locally unresectable acinar cell carcinoma. With sufficient expertise, negative surgical resection margins are possible even with vascular involvement. Due to the generally poor prognosis associated with acinar cell carcinoma, such aggressive treatment measures are warranted.
Imaging Findings of Adenocarcinoma Arising from Lingual Foregut Duplication Cyst
Authors: Jung Youn Kim, Na Yeon Yoon, Sung-Eun Choi
Journal: J Belg Soc Radiol (2023)
Keywords: adenocarcinoma, foregut duplication cyst, head and neck, head and neck imaging, lingual, tongue
MeSH terms: Case Reports

Lingual foregut duplication cysts are rare developmental anomalies with varied symptoms, and adenocarcinomas may develop from them. Radiological evaluations, including computed tomography and magnetic resonance imaging, can help diagnose these lesions and determine their extent. Abnormal enhancement should raise the suspicion of malignancy of a lingual foregut duplication cyst. Early detection and complete surgical resection of lingual foregut duplication cysts are necessary to prevent malignant transformations. Complete tumor resection with adjuvant radiotherapy or radiochemotherapy is recommended. The teaching point is that mucinous adenocarcinoma can develop from a lingual foregut duplication cyst, and radiological studies may aid in the diagnosis.
Teaching point:
Adenocarcinomas can develop from lingual foregut duplication cysts, which are rare developmental anomalies, and radiologic studies may aid in the diagnosis.
A case report of Lipoblastoma: Presenting as a swelling in the nape of the neck of 14 years old girl
Authors: Shabbar Hussain Changazi, Ghulam Mujtaba Ghuman, Aamir Bashir, Samiullah Bhatti, Mustansar Iqbal, Usman Ismat
Journal: Int J Surg Case Rep (2018)
Keywords: adolescence, case report, lipoblastoma, neck swelling

Introduction:
Lipoblastoma usually develops in extremities and trunk during infancy or childhood. Its occurrence in head and neck is rare.
Case presentation:
Here we present a case of lipoblastoma in 14 years old female who developed swelling in the nape of her neck. Initially the diagnosis of lymphangioma was made on the basis MRI findings but histopathology after excisional biopsy confirmed it to be lipoblastoma.
Conclusion:
Lipoblastoma can rarely present as swelling in the nape of neck in adolescents.
Mild reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant: First case report from Indonesia
Authors: Naniek Isnaini, Yan Mardian, Dewi Lokida, Fajar Budiono, Deni P Butar-Butar, Dona Arlinda, Gustiani Salim, Herman Kosasih, Wahyu Nawang Wulan, Jacqueline Perodin, Aaron Neal, H Clifford Lane, Muhammad Karyana
Journal: Front Med (Lausanne) (2022)
Keywords: covid-19, delta variant, indonesia, case report, reinfection
MeSH terms: Case Reports

Background:
Reinfection with SARS-CoV-2 has been well documented, yet little is known about the degree of protection a previous infection provides against reinfection, especially against Variants of Concern (VOC).
Case presentation:
Here we describe a case of an unvaccinated 49-year-old man who experienced two sequential SARS-CoV-2 infections with two different variants, as evidenced by genomic sequencing. The first episode was caused by the Pango lineage B.1.466.2 and resulted in severe COVID-19 with 5 days in an intensive care unit (ICU). The second episode occurred approximately 6 months later, during the Delta surge in Indonesia. Genomic analysis showed that the second infection was caused by the Delta variant (Pango lineage B.1.617.2) and resulted in mild disease that did not require hospitalization. No SARS-CoV-2 nucleic acid was detected between the two episodes, but both binding and neutralizing antibodies to SARS-CoV-2 were detected prior to the reinfection, with the second infection leading to an increase in the levels of antibody.
Conclusion:
We confirmed that the patient experienced a reinfection instead of persistent viral shedding from the first infection based on epidemiological, clinical, serological, and genomic analyses. Our case supports the hypothesis that SARS-CoV-2 reinfection may occur once antibody titers decrease or following the emergence of a new variant. The milder presentation in the patient's second infection deserves further investigation to provide a clear picture of the role of post-infection immunity in altering the course of subsequent disease.
Diagnosis and management of intramural ectopic pregnancy in the second trimester-a case report
Authors: Long Kong, Ning Mao, Yinghong Shi, Heng Ma, Haizhu Xie
Journal: BJR Case Rep (2017)
MeSH terms: Case Reports

Intramural ectopic pregnancy is one of the rarest types of ectopic pregnancy, with risk of 1:30000. Confirmation of intramural ectopic pregnancy is difficult and is often performed intraoperatively. Intramural ectopic pregnancy often requires hysterectomy to avoid life-threatening haemorrhage. We present a case of intramural ectopic pregnancy in the second trimester, including its diagnostic criteria and treatment plan. Transvaginal ultrasound and MRI are important non-invasive methods in diagnosing this type of ectopic pregnancy. Clinicians should provide consideration to a combination of strategies and do their best to preserve patients' uteri and fertility. In this case, clinicians excluded the gestational sac, repaired the uterus and saved the patient's fertility.
A Challenging Case of Refractory Hepatic Encephalopathy in a Postliver Retransplant Patient with Thrombosed Portal Vein: A Shunt for a Shunt
Authors: Fady Salama, Anna Christina Leyson, Malay Shah, Roberto Galuppo Monticelli
Journal: Case Reports Hepatol (2023)
MeSH terms: Case Reports

Hepatic encephalopathy (HE) is a frequent and serious complication of chronic liver disease. The mechanism of hepatic encephalopathy is not entirely clear. Hepatic encephalopathy is defined as brain dysfunction caused by liver insufficiency and/or portal-systemic blood shunting. It manifests as a wide spectrum of neurological or psychiatric abnormalities, ranging from subclinical alterations, detectable only by neuropsychological or neurophysiological assessment, to coma. Liver transplant (LT) is the definitive treatment for refractory hepatic encephalopathy. In this case, we present a challenging case of refractory hepatic encephalopathy in a postliver transplant patient with portal vein thrombosis and a splenorenal shunt treated with a novel technique to address his complex anatomy.
Clinical Case Studies in Psychoanalytic and Psychodynamic Treatment
Authors: Jochem Willemsen, Elena Della Rosa, Sue Kegerreis
Journal: Front Psychol (2017)
Keywords: clinical case study, methodology, psychoanalysis, psychoanalytic schools, psychotherapy research, review, theoretical pluralism
MeSH terms: Review

This manuscript provides a review of the clinical case study within the field of psychoanalytic and psychodynamic treatment. The method has been contested for methodological reasons and because it would contribute to theoretical pluralism in the field. We summarize how the case study method is being applied in different schools of psychoanalysis, and we clarify the unique strengths of this method and areas for improvement. Finally, based on the literature and on our own experience with case study research, we come to formulate nine guidelines for future case study authors: (1) basic information to include, (2) clarification of the motivation to select a particular patient, (3) information about informed consent and disguise, (4) patient background and context of referral or self-referral, (5) patient's narrative, therapist's observations and interpretations, (6) interpretative heuristics, (7) reflexivity and counter-transference, (8) leaving room for interpretation, and (9) answering the research question, and comparison with other cases.
Successful Anti-CLL1 CAR T-Cell Therapy in Secondary Acute Myeloid Leukemia
Authors: Hui Zhang, Wen-Ting Gan, Wen-Ge Hao, Peng-Fei Wang, Zhuo-Yan Li, Lung-Ji Chang
Journal: Front Oncol (2020)
Keywords: car t-cell therapy, cll1, myelodysplastic syndrome, myeloproliferative neoplasm, secondary acute myeloid leukemia
MeSH terms: Case Reports

Secondary acute myeloid leukemia (sAML) is a high-risk AML evolving from heterogenous prior hematological disorders. Compared to de novo AML, sAML has even worse responses to current therapy and thus is associated with lower remission rates, inferior overall survival (OS) and higher relapse rates. Many efforts have been devoted to improving the overall but with limited success, and novel strategy is thus highly needed. Recent research has identified that CLL1 is highly expressed on AML leukemia stem cells and blasts cells but not on normal hematopoietic stem cells. In this case report, we treated a secondary AML patient with anti -CLL1 CAR-T therapy and achieved morphological, immunophenotypic and molecular complete remission for over 10 months. Although only one successful case is presented here, the anti-CLL1 CAR T-cells should be considered as another treatment option for secondary AML in the future.
Bilateral anterior ischemic optic neuropathy and choroidal ischemia in a patient with COVID-19 infection
Authors: Seyed Hossein Ghavami Shahri, Mojtaba Abrishami, Helia Shayanfar, Sahel Khazaei
Journal: Clin Case Rep (2023)
Keywords: sars‐cov‐2, angle‐closure glaucoma, anterior ischemic optic neuropathy, choroidal ischemia
MeSH terms: Case Reports

A 57-year-old male known case of diabetes mellitus presented with gradually bilateral decreased vision accompanied by ocular pain two weeks after diagnosis of SARS-CoV-2 infection. The results of examination and imaging were indicative of bilateral anterior ischemic optic neuropathy (AION) and massive choroidal ischemia, which may be associated with SARS-CoV-2-induced damages, including endothelial damage, hypercoagulable state, and hypoxia.
Case report: Intraoperative frozen section analysis of Thyroid paraganglioma
Authors: Huanyu Zhao, Yudie Lu, Jingrong Zheng, Yuyao Xie, Qingchang Li
Journal: Front Oncol (2022)
Keywords: case report, differential diagnosis, immunohistochemical staining, intraoperative frozen section, management approach, thyroid follicular adenoma, thyroid paraganglioma
MeSH terms: Case Reports

Paraganglioma (PGL) is a neuroendocrine tumor that arises from the sympathetic or parasympathetic paraganglia. Primary thyroid PGL is extremely rare. PGL may be difficult to diagnose on frozen sections because its histopathological features, such as polygonal tumor cells with eosinophilic cytoplasm arranged irregularly, overlap with those of thyroid follicular adenoma. We present a case of thyroid PGL in a female patient and provide a detailed description of the patient's clinicopathologic characteristics. Cervical computed tomography showed a left thyroid mass with uneven density. Intraoperative frozen section analysis showed an uneven fibrous septa and rich networks of delicate vessels surrounding tumor cell nests. The tumor cells were polygonal or epithelioid with eosinophilic cytoplasm, arranged in a nest, trabecular, or organoid pattern were and diagnosed as thyroid follicular adenoma. However, in postoperative immunohistochemistry, these were diagnosed as thyroid PGL. The postoperative recovery was uneventful. The patient showed no signs of tumor recurrence or metastasis until 16 months of follow-up. Herein, we summarize the characteristic features of thyroid PGL based on frozen section analysis. In the appropriate clinical context, its proper use as diagnostic and differential diagnostic management strategies is recommended.
Caseous Calcification of the Mitral Valve
Authors: Birgitt Janssens, Thiebault Saveyn, Benjamin Leenknegt
Journal: J Belg Soc Radiol (2023)
Keywords: cmac, caseous mitral valve calcification, computed tomography, transthoracic ultrasound
MeSH terms: Case Reports

Teaching Point: Caseous calcification of the mitral annulus is a benign mass-like lesion which can mimic cardiac tumor or abscess; therefore, multimodal imaging should be considered, avoiding unnecessary interventions.
Peripheral Neuropathy and VIth Nerve Palsy Related to Randall Disease Successfully Treated by High-Dose Melphalan, Autologous Blood Stem Cell Transplantation, and VIth Nerve Decompression Surgery
Authors: C Foguem, P Manckoundia, P Pfitzenmeyer, J-L Dupond
Journal: Case Rep Med (2010)
MeSH terms: Case Reports

Randall disease is an unusual cause of extraocular motor nerve (VI) palsy. A 35-year-old woman was hospitalized for sicca syndrome. The physical examination showed general weakness, weight loss, diplopia related to a left VIth nerve palsy, hypertrophy of the submandibular salivary glands, and peripheral neuropathy. The biological screening revealed renal insufficiency, serum monoclonal kappa light chain immunoglobulin, urinary monoclonal kappa light chain immunoglobulin, albuminuria, and Bence-Jones proteinuria. Bone marrow biopsy revealed medullar plasma cell infiltration. Immunofixation associated with electron microscopy analysis of the salivary glands showed deposits of kappa light chains. Randall disease was diagnosed. The patient received high-dose melphalan followed by autostem cell transplantation which led to rapid remission. Indeed, at the 2-month followup assessment, the submandibular salivary gland hypertrophy and renal insufficiency had disappeared, and the peripheral neuropathy, proteinuria, and serum monoclonal light chain had decreased significantly. The persistent diplopia was treated with nerve decompression surgery of the left extraocular motor nerve. Cranial nerve complications of Randall disease deserve to be recognized.
Identification of a novel homozygous LAMB3 mutation in a Chinese male with junctional epidermolysis bullosa and severe urethra stenosis: A case report
Authors: Wei Wang, Qiang Guo, Jinshan Chen, Xi Zhang, Chengyong Li, Shuangping Li, Jialin Liang, Chuan Hao, Jingqi Wang
Journal: Front Genet (2022)
Keywords: lamb3, epidermolysis bullosa, mutation, urethral stricture, urological complications
MeSH terms: Case Reports

Introduction: Epidermolysis bullosa (EB) is a skin fragility disorder that is caused by molecular aberrations in the epidermal basement membrane zone. Based primarily on the cleavage plane within the skin, EB is classified into four major subtypes: EB simplex; junctional EB (JEB); dystrophic EB; and Kindler EB. The junctional form (JEB) can lead to blistering and a variety of extracutaneous complications, including genitourinary tract involvement. Despite therapeutic progress, treatment modalities for urological complications of JEB are currently limited. Results: We present the case of a Chinese male with intermediate JEB and profound urinary tract stenosis. Due to the progression of the urinary tract stenosis, he presented with repeated urological symptoms, such as high frequency of urination, painful urination, and difficult voiding. After birth, multiple blisters on the fingers, feet, and limbs, as well as nail dystrophies and spare hair were noted. Mutation analysis revealed that the patient carried a homozygous frameshift mutation in the LAMB3 gene [c.1172_1179delinsTGTGTGTGCAAGGAG/p. (P391Lfs*23)]. After receiving treatment for urethral dilatation, lingual mucosa for anterior urethroplasty, and repair of urethral stricture using a ventral onlay penile skin flap, the patient still experienced a relapse of urinary tract stenosis. Finally, the patient underwent perineal urethrostomy. In contrast, his older brother with similar urological symptoms received regular urethral dilatation, and the curative effect was positive. Conclusion: Here we report on a case with a novel LAMB3 mutation that led to JEB with profound urinary tract stenosis, which has expanded our experience in the treatment of EB urological complications.
Post-operative transmesosigmoid hernia causing small bowel obstruction: a case report
Authors: Robleh Hassan Farah, Yassine Fahmi, Driss Khaiz, Khalid Elhattabi, Fatimazahra Bensardi, Rachid Lefriyekh, Saad Berrada, Abdelaziz Fadil, Najib Zerouali Ouariti
Journal: Pan Afr Med J (2015)
Keywords: internal hernia, intestinal obstruction, transmesosigmoid hernia
MeSH terms: Hernia, Abdominal / complications, Herniorrhaphy / methods, Incisional Hernia / complications, Intestinal Obstruction / etiology, Case Reports, Abdominal Pain / etiology, Adult, Hernia, Abdominal / surgery, Humans, Incisional Hernia / surgery, Intestinal Obstruction / diagnosis, Intestinal Obstruction / surgery, Intestine, Small / pathology, Laparotomy, Male

Internal hernia is an unusual cause of small bowel obstruction and classified several types according to locations. Transmesosigmoid hernia is rare type among others mesosigmoid hernia was rarely reported in the literature. We report the case of a 44-year-old male who presented with acute abdominal pain and developed a small intestinal obstruction. History, clinical and radiography examination were suggested intestinal obstruction due to postoperative adhesion. The diagnosis of small bowel obstruction due to internal hernia was confirmed by laparotomy exploration. The herniated loop was reduced successfully and the defect was approximated with interrupted sutures. The postoperative course was uneventful and the patient is free from symptoms and recurrence. This case report highlight difficulty and importance of high index of suspicion considering an internal hernia as a cause of small bowel obstruction in individuals of all age groups with or without a previous history of abdominal surgery.
Duodenal perforation with an unusual presentation: a case report
Authors: Arif Hussain Sarmast, Fazl Q Parray, Hakim Irfan Showkat, Yasir A Lone, Naseer A Bhat
Journal: Case Rep Infect Dis (2011)
MeSH terms: Case Reports

A young female presented with classical complaints suggestive of peptic ulcer disease leading to signs of peritonitis. The said patient after being subjected to baseline workup was subjected to laparotomy which proved to be a surgical surprise. A live ascaris lumbricoides worm was seen pouting out of a duodenal perforation.
High-Resolution Transperineal Ultrasound in Anorectal Malformations-Can We Replace the Distal Colostogram?
Authors: Francesca Palmisani, Wilfried Krois, Janina Patsch, Martin Metzelder, Carlos A Reck-Burneo
Journal: European J Pediatr Surg Rep (2022)
Keywords: anorectal malformations, diagnostics, reconstructive surgery, ultrasound
MeSH terms: Case Reports

Introduction Anorectal malformations (ARM) affect 1 in 5,000 newborns with a wide range of defects. In the absence of a visible fistula, the diagnosis and classification of ARM require an augmented pressure distal colostogram. This procedure can be done after a diverting colostomy has been performed and implies exposing the child to radiation. We hypothesized that high-resolution transperineal ultrasound could correctly diagnose the type of ARM, thus sparing radiation exposure. Case Description Four full-term male newborns with ARM and no visible anal opening were referred to our center for further management. A diverting descendostomy was performed in the first 48 hours of life in all cases. Prior to the reconstructive surgery, we performed a high-resolution transperineal ultrasound with 3D tomographic reconstruction of the perineal region to assess the urethra, the rectum, and a possible fistula. Findings were compared with a conventional augmented pressure distal colostogram. The image acquisition was fast and did not cause any additional distress to the children. Conclusion In all cases the results of the distal colostogram nicely correlated with the high-resolution transperineal ultrasound with 3D tomographic reconstruction. In the future, we envision a time when it can potentially replace the distal colostogram in preoperative assessment of ARM with no distress and exposure to radiation.