OpenMed/multicare-articles huggingface dataset:
Early Stone Manipulation in Urinary Tract Infection Associated with Obstructing Nephrolithiasis
Authors: Megan L Swonke, Ali M Mahmoud, Elias J Farran, Tamer J Dafashy, Preston S Kerr, Christopher D Kosarek, Joseph Sonstein
Journal: Case Rep Urol (2018)
MeSH terms: Case Reports

A urinary tract infection (UTI) and sepsis secondary to an obstructing stone are one of the few true urological emergencies. The accepted management of infected ureteral stones includes emergent decompression of the collecting system as well as antibiotic therapy. Despite this, no consensus guidelines clarify the optimal time to undergo definitive stone management following decompression. Historically, our institution has performed ureteroscopy with laser lithotripsy (URS-LL) treatment at least 1 to 2 weeks after decompression to allow for clinical improvement and completion of an antibiotic course. In this case series, we retrospectively review four cases in which patients had a documented UTI secondary to an obstructive ureteral stone. The patients underwent urgent decompression and, based on labs and clinical improvement, were subsequently treated with URS-LL. The presented patients received URS-LL within 5 days of decompression and antibiotics. The patients had no sepsis related postoperative complications from the accelerated course of treatment, resulting in discharge within 2 days following URS-LL. We provide a detailed examination of each patient presentation to describe our institution's experience with treating infected kidney stones within days of urgent decompression in order to question the previous standard of treating an infected kidney stone with a more delayed intervention.
Hard and Soft Tissue Augmentation with Single-Implant Restoration in the Esthetic Zone
Authors: Igor Ashurko, Nataliia Blagushina, Anisa Borodiy, Mary Magdalyanova
Journal: Case Rep Dent (2021)
MeSH terms: Case Reports

The removal of the central incisor of the upper jaw is a challenging process, since the restoration of a single implant in the esthetic zone is of great responsibility. When tooth extraction with immediate implant placement is not possible, modern protocols imply the use of the socket preservation technique. This method of preserving socket properties significantly reduces changes that occur during the healing process of the postextracted area and along with soft tissue augmentation allows to achieve a satisfying aesthetic result. The aim of present case report is to assess capabilities of socket preservation concept and application of soft tissue augmentation in the anterior maxillary region. The treatment steps of a 35-year-old woman who needed to remove tooth 11 with further dental implant placement are described. The clinical case is of interest because after socket preservation and soft tissue augmentation, an acceptable aesthetic result was not reached. However, additional soft tissue augmentation made it possible to achieve the desired result, which was stable for 7 years.
Asymptomatic Mediastinal Extra-adrenal Paraganglioma as a Cause of Sudden Death: A Case Report
Authors: Qiancheng Xu, Yingya Cao, Hongzhen Yin, Rongrong Wu, Tao Yu, Weihua Lu
Journal: Open Life Sci (2019)
Keywords: cardiothoracic surgery, endocrine

A 23-year-old female patient was referred for treatment of a posterior mediastinal tumour. There was no history of hypertension or headache and no other complaints. The patient's blood pressure increased to 210/125 mmHg after surgically manipulating the tumour, subsequently reversing to severe hypotension (25/15 mmHg) immediately after the tumour was removed. The life-threatening and irreversible blood pressure drop was difficult to treat with fluid and vasopressors, and the patient ultimately died of cardio-respiratory failure. Asymptomatic paraganglioma can be non-functional but can also be fatal. For any lump in the thoracic cavity, paraganglioma should be ruled out.
Fulminant Course of Neuromyelitis Optica in a Patient With Anti-MDA5 Antibody-Positive Dermatomyositis: A Case Report
Authors: You-Ri Kang, Kun-Hee Kim, Tai-Seung Nam, Kyung-Hwa Lee, Kyung Wook Kang, Seung-Jin Lee, Seok-Yong Choi, Gopalakrishnan Chandrasekaran, Myeong-Kyu Kim
Journal: Front Med (Lausanne) (2020)
Keywords: antibody, clinically amyopathic dermatomyositis, ferritin, interstitial lung disease, neuromyelitis optica, rituximab
MeSH terms: Case Reports

Anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody is a myositis-specific marker detected in clinically amyopathic dermatomyositis (DM). DM with anti-MDA5 antibody can be accompanied by rapidly progressive interstitial lung disease (RP-ILD) and other autoimmune disorders. Until now, only one case of neuromyelitis optica (NMO) with anti-MDA5-positive DM has been reported worldwide, in which the patient achieved a favorable outcome with intensive immunotherapy. We report a case of NMO in a patient with anti-MDA5-positive DM complicated by ILD and rheumatoid arthritis. Our patient experienced a fulminant course of NMO, rather than RP-ILD, in the presence of hyperferritinemia, which resulted in profound neurological sequelae despite immunotherapy including rituximab.
The importance of audio-video documentation during polysomnography for diagnosis of catathrenia in a 6-year-old child: case report
Authors: Nubia Santana Argollo, Diderot Rodrigues Parreira, Lucas Carneiro Pereira
Journal: Sleep Sci (2021)
Keywords: central sleep apnea, polysomnography, sleep apnea syndromes

Catathrenia is a rare disorder classified as a respiratory one and characterized by expiratory groans during sleep. We report a case of catathrenia in a 6-year-old male patient, with documented video and audio polysomnography. The diagnosis of catathrenia is made through a detailed analysis of video and audio recordings during the examination. Although there is no association with the risk of physical damage known today, catathrenia presents itself as a source of anxiety among patients and their families. The differentiation of catathrenia with central apnea, obstructive apnea, primary snoring, and parasomnias will influence both the prognosis and the diagnosis and treatment of the patient.
Laparoscopic excision of a retroperitoneal mucinous cystic neoplasm: A case report
Authors: John Lung, Allison Gracey, Abigail Rosales, Eva Bashover, Alan Sbar, M Haris Nazim, Ferdinand Rico
Journal: Int J Surg Case Rep (2019)
Keywords: case report, laparoscopic removal, mucinous cystic neoplasm

Introduction:
A 22-year-old female presented with a large abdominal mass that was revealed to be a primary retroperitoneal mucinous cystadenoma.
Presentation of case:
A 22-year-old female presented with a two day history of bloating, mid-epigastric pain, and nausea without vomiting. A CT scan of her abdomen/pelvis showed a large left retroperitoneal mass, possibly a mesenteric cyst. The patient underwent laparoscopic surgery for mass excision. Once the cystic mass was completely dissected laparoscopically, it was placed in a large endobag. The fluid was then aspirated while in the bag to decompress and then completely taken out through a port site. She was discharged the following day. Final pathology revealed a benign mucinous cystadenoma/cystadenofibroma of mesenteric origin.
Discussion:
Primary retroperitoneal mucinous cysts are rare occurrences and benign mucinous cystadenomas are the rarest subtype. We use an innovative laparoscopic technique with complete excision of the cyst without spillage of content, thus preventing possible seeding in case of malignancy.
Conclusion:
There is some previous caution in using a laparoscopic approach for cystic masses due to potential seeding intra-operatively, in case of fluid spillage of a possible malignant neoplasm. We show through our case that it is possible to efficiently and safely use such an approach.
Combined treatment of transluminal Nd:YAG laser embolysis and hyperbaric oxygen for branch retinal artery occlusion
Authors: Hasim Uslu, Ayse Yagmur Kanra
Journal: GMS Ophthalmol Cases (2020)
Keywords: nd
MeSH terms: Case Reports

Objective: To describe the clinical efficiency of transluminal Nd:YAG laser embolysis (TYE) and hyperbaric oxygen (HBO) as an off-label combined treatment for branch retinal artery occlusion (BRAO) with visible emboli. Methods: A 77-year-old woman had a history of seeing a "shadow" in the lower visual field of the left eye for three days. Platelet-fibrin embolus at the arterial bifurcation was disintegrated by TYE technique and the patient was referred to HBO treatment for 20 sessions. Results: One week after treatment, best-corrected visual acuity improved to 0.8 while a good arterial blood flow in the affected branch was seen. Platelet fibrin plaques had disappeared at fundus, and the pale appearance in the retina had decreased. Conclusions: TYE and HBO combination treatment may be an effective and feasible treatment for restoration of blood flow and vision in BRAO cases caused by visible platelet-fibrin emboli.
Methotrexate induced lung injury in a patient with primary CNS lymphoma: a case report
Authors: Puneet Chhabra, Arjun Dutt Law, Vikas Suri, Pankaj Malhotra, Subhash Varma
Journal: Mediterr J Hematol Infect Dis (2012)
MeSH terms: Case Reports

Methotrexate is an antimetabolite commonly used in clinical practice for a variety of indications ranging from rheumatoid arthritis and other connective tissue disorders to high dose regimens in many malignancies. This folate antagonist has got a spectrum of toxicities among which gastrointestinal effects predominate. Lung injury is a well described but rare event and has been reported most often in patients who have been on long term oral therapy for rheumatic disorders. Acute lung injury in a patient receiving a high dose regimen for haematological malignancies has not been reported previously. We present one such case of methotrexate related acute lung injury in a patient of primary CNS lymphoma receiving high dose methotrexate.
Novel Management for Severe Odontogenic Maxillary Sinusitis Based on Pathophysiology
Authors: Yoshio Ohyama, Masaru Ogawa, Satoshi Yokoo
Journal: Case Rep Dent (2022)
MeSH terms: Case Reports

Endoscopic sinus surgery is commonly performed to treat odontogenic maxillary sinusitis. However, recurrence and natural ostium reclosure often occur due to the inadequate patency of the excretory route. Furthermore, classical maxillary sinus radical surgery is still performed for odontogenic maxillary sinusitis even though it can cause postoperative maxillary sinus deformation, loss of function, and a postoperative maxillary cyst. A management that addresses these issues has not yet been identified. This study reported a conservative maxillary sinus management, wherein a nasoantral window is prepared and the thickened maxillary sinus mucosa is preserved, using the Caldwell-Luc approach. This study presents a case of severe odontogenic maxillary sinusitis that spread to the frontal sinus. This novel management facilitated complete recovery from severe odontogenic maxillary sinusitis in this case.
An enormous arteriovenous malformation presenting in a child in sacro-gluteal region and managed successfully by recurrent embolisation and surgery
Authors: Amjad Ghareeb, Ameer Kakaje, Ayham Ghareeb, Mohamad Ali Nahas
Journal: Int J Surg Case Rep (2020)
Keywords: arteriovenous malformations, buttocks, embolisation, middle east, paediatric, vascular surgery, financial disadvantage
MeSH terms: Case Reports

Background:
Arteriovenous malformations (AVMs) are rare congenital lesions that affect multiple regions. AVMs often affect the brain and the buttock is the least common. They are usually congenital, but discovered later in life as they are asymptomatic, small and resemble a benign lesion. However, they can abruptly grow and become symptomatic and life-threatening as they can bleed and get infected.
Presentation of case:
An eight-year-old girl presented with ulcerated and bleeding AVM at the sacro gluteal region. However, due to financial difficulty, it grew to reach an enormous size of (15*15*2 cm) in the buttock. It was later managed by multiple embolisation followed by total surgical resection.
Discussion:
This case reflects the first case of enormous AVM in the sacro-gluteal region in a child in the Middle East as they rarely reach such huge sizes. Total resection was possible by repeat embolisation and surgery.
Conclusion:
Embolisation can render even huge AVM operable. AVMs should be treated as early as possible as they continue to grow and drastically decrease the quality of life of the patient.
Family COVID-19 cluster analysis of an infant without respiratory symptoms
Authors: Myrela Conceição Santos de Jesus, Alexandra Giovanna Aragão Lima, Victor Santana Santos, Luciane Moreno Storti-Melo, Tatiana Rodrigues de Moura, Rafaela Windy Farias Dos Santos, Cliomar Alves Dos Santos, Paulo Ricardo Martins-Filho, Luis Eduardo Cuevas, Ricardo Queiroz Gurgel
Journal: Rev Soc Bras Med Trop (2020)
MeSH terms: Coronavirus / isolation & purification, Coronavirus Infections / diagnosis, Diarrhea / diagnosis, Pandemics, Pneumonia, Viral / diagnosis, Case Reports, Abdominal Pain / etiology, Betacoronavirus, COVID-19, Child, Preschool, Clinical Laboratory Techniques, Cluster Analysis, Contact Tracing, Diarrhea / etiology, Fever / etiology, Humans, Male, Pharyngitis / etiology, SARS-CoV-2

Diagnosing cases of coronavirus disease (COVID-19) with only non-respiratory symptoms has been challenging. We reported the diagnosis of a child who tested positive for COVID-19 with abdominal pain/diarrhea and tracked his family cluster. One member of the family tested positive for COVID-19 on real-time reverse-transcription polymerase chain reaction assay and three other family members had anti-SARS-CoV-2 antibodies.
Case report: A rare variant m.4135T>C in the MT-ND1 gene leads to Leber hereditary optic neuropathy and altered respiratory chain supercomplexes
Authors: Tereza Rákosníková, Silvie Kelifová, Hana Štufková, Kateřina Lokvencová, Petra Lišková, Bohdan Kousal, Tomáš Honzík, Hana Hansíková, Václav Martínek, Markéta Tesařová
Journal: Front Genet (2023)
Keywords: complex i, mitochondria, mtdna, optic neuropathy, supercomplexes
MeSH terms: Case Reports

Leber hereditary optic neuropathy is a primary mitochondrial disease characterized by acute visual loss due to the degeneration of retinal ganglion cells. In this study, we describe a patient carrying a rare missense heteroplasmic variant in MT-ND1, NC_012920.1:m.4135T>C (p.Tyr277His) manifesting with a typical bilateral painless decrease of the visual function, triggered by physical exercise or higher ambient temperature. Functional studies in muscle and fibroblasts show that amino acid substitution Tyr277 with His leads to only a negligibly decreased level of respiratory chain complex I (CI), but the formation of supercomplexes and the activity of the enzyme are disturbed noticeably. Our data indicate that although CI is successfully assembled in the patient's mitochondria, its function is hampered by the m.4135T>C variant, probably by stabilizing CI in its inactive form. We conclude that the m.4135T>C variant together with a combination of external factors is necessary to manifest the phenotype.
En Face Optical Coherence Tomography Imaging Ellipsoid Zone Regeneration in Laser-Induced and Solar Maculopathies
Authors: Jeanne M Gunzinger, Katrin Fasler, Daniel Barthelmes, Peter Maloca, Pascal W Hasler, Christian Böni, Sandrine A Zweifel
Journal: Case Rep Ophthalmol Med (2019)
MeSH terms: Case Reports

The purpose of the study was to analyze imaging findings in spectral domain en face optical coherence tomography (SD OCT) in patients with laser-induced and solar maculopathies focusing on the possible regeneration of the ellipsoid zone. In a retrospective case series of 3 patients (4 eyes) with solar maculopathy and 2 patients (3 eyes) with laser-induced maculopathy who underwent a comprehensive ocular examination, ellipsoid zone (EZ) was segmented from SD OCT data. Evaluation of EZ in en face OCT revealed a hyporeflective lesion surrounded by a hyperreflective border. The area of EZ alteration was measured manually in en face OCT. All patients showed partial EZ regeneration. Mean EZ alteration decreased from 0.12 mm2 (range: 0.05-0.32) at baseline to 0.07 mm2 (range: 0.01-0.22) at last follow-up (p = 0.018, mean follow-up: 372 days; range: 115-592). Mean best visual acuity (BVA) improved from 20/36 at baseline to 20/30 (p = 0.018). In conclusion, en face OCT imaging clearly delineated the area of EZ alteration in patients with laser-induced and solar maculopathies. Follow-up showed significant reformation of the EZ as well as improvement of BVA.
Sumatriptan Induced Takotsubo Cardiomyopathy; the Headache of the Heart: A Case Report
Authors: Jay Mohan, Akarsh Parekh, Michael DeYoung
Journal: Front Cardiovasc Med (2019)
Keywords: takotsubo cardiomyopathy, broken heart syndrome, cardiomyopathy, headaches, migraines, stress-induced cardiomyopathy, sumatriptan, triptans
MeSH terms: Case Reports

Takotsubo Cardiomyopathy (TCM) is an increasing recognized form of acute reversible left ventricular systolic dysfunction not related to obstructive coronary disease. The exact physiology of this disorder is not yet known, however multiple agents have been hypothesized to have a link to this condition. Most commonly, TCM has been hypothesized as being triggered by a catecholamine surge after an inciting event. New evidence now suggests certain medications as a link to the disease. We describe a unique case of TCM in a woman after taking Treximet (naproxen and sumatriptan) as abortive therapy for a migraine.
Papillary fibroelastoma arising from the coumadin ridge
Authors: Mahim Malik, Konstantin Shilo, Ahmet Kilic
Journal: J Cardiovasc Thorac Res (2017)
Keywords: fibroelastoma, left atrium, tumor
MeSH terms: Case Reports

Cardiac papillary fibroelastomas (CPF) are rare cardiac tumors, mostly found on the valvular surfaces in the heart. These tumors are frond like in nature and are benign, intracardiac masses, rarely causing any hemodynamic disturbances. However, excision of these masses is indicated due to their propensity to embolize. We present a case report of the tumor found on the coumadin ridge, causing transient ischemic attacks in a patient. We performed complete excision of the tumor via median sternotomy on cardiopulmonary bypass support with cardiac arrest. The diagnosis was confirmed by histological examination. The patient had an uneventful postoperative course and was discharghed on postoperative day 4. She has had complete resolution of her symptoms post excision. The diagnosis of the mass was confirmed on histological examination.
A family with Robertsonian translocation: a potential mechanism of speciation in humans
Authors: Jieping Song, Xi Li, Lei Sun, Shuqin Xu, Nian Liu, Yanyi Yao, Zhi Liu, Weipeng Wang, Han Rong, Bo Wang
Journal: Mol Cytogenet (2016)
Keywords: chromosome karyotype, evolution, fish, robertsonian translocation homozygosity, acgh
MeSH terms: Case Reports

Background:
Robertsonian translocations occur in approximately one in every 1000 newborns. Although most Robertsonian translocation carriers are healthy and have a normal lifespan, they are at increased risk of spontaneous abortions and risk of producing unbalanced gametes and, therefore unbalanced offspring. Here we reported a previously undescribed Robertsonian translocation.
Case presentation:
We identified three Robertsonian translocation carriers in this family. Two were heterozygous translocation carriers of 45,XX or XY,der(14;15)(q10;q10) and their son was a homozygous translocation carrier of a 44,XY,der(14;15)(q10;q10), der(14;15)(q10;q10) karyotype. Chromosomal analysis of sperm showed 99.7 % of sperm from the homozygous translocation carrier were normal/balanced while only 79.9 % of sperm from the heterozygous translocation carrier were normal/balanced. There was a significantly higher frequency of aneuploidy for sex chromosome in the heterozygous translocation carrier.
Conclusions:
The reproductive fitness of Robertsonian translocation carriers is reduced. Robertsonian translocation homozygosity can be a potential speciation in humans with 44 chromosomes.
Cocaine-associated myocardial infarction: should they all be stented?
Authors: Sazzli Kasim, Ronan O'Donabhain, Eugene Mcfadden
Journal: Case Rep Cardiol (2011)
MeSH terms: Case Reports

Cocaine use is a known cause of chest pain and acute myocardial infarction and frequently leads to cardiac catheterization procedure. The treatment of cocaine-related acute coronary syndromes presents unique challenges because a variety of mechanisms including atherosclerotic plaque rupture, platelet activation, and coronary vasospasm may contribute to the pathogenesis. Our case highlights important considerations taken in dealing with this acute scenario.
Occam's Razor Versus Hickam's Dictum: A Case Report of Junctional Epidermolysis Bullosa and Lower Urinary Tract Infection
Authors: Abdur Rehman, Hassan Raza, Beenish Fatima Zia, Fatima Farahi, Meeran Asher Syed
Journal: Cureus (2023)
Keywords: hemorrhagic bullae, junctional epidermolysis bullosa, newborn and child health, oral mucosal lesions, urinary tract infection
MeSH terms: Case Reports

Epidermolysis bullosa (EB) is a rare heterogeneous group of diseases which typically presents with extensive blistering and mucocutaneous erosions. EB is mechanobullous in nature and thus commonly involves sites of trauma and friction. It is a painful and disfiguring disorder. The involvement of different internal organs and systems, such as respiratory, genitourinary, and gastrointestinal systems, has been reported in the literature depending on the type of EB. We report a case of junctional epidermolysis bullosa (JEB) with urogenital involvement in a female child in Pakistan. JEB is a rare subtype of EB which is transmitted in an autosomal recessive pattern of inheritance. It classically affects neonates. Diagnosis is established after clinical examination, and investigations are directed at the exploration of skin lesions such as histopathological and direct immunofluorescence studies. Management of patients is primarily supportive.
Failure of ketamine anesthesia in a patient with lamotrigine overdose
Authors: Daniel Kornhall, Erik Waage Nielsen
Journal: Case Rep Crit Care (2014)

Introduction. It is important to know which clinical situations prevent ketamine from working. Case Report. We present the case of the psychiatric inpatient who was admitted to our emergency department after ingesting a toxic dose of lamotrigine, unknown at that time. On admission, she was clearly in distress, displaying extreme agitation and violent ataxic movements. We opted to achieve sedation using intravenous ketamine boluses. Unexpectedly, after being injected with a total of 250 mg ketamine, our patient displayed no signs of dissociative anaesthesia. Discussion. There was no apparent reason for why ketamine failed, but an interaction between lamotrigine and ketamine was suspected. A literature search was performed. Very few articles describe interactions between lamotrigine and ketamine. Experimental studies, however, demonstrate how lamotrigine attenuates the neuropsychiatric effects of ketamine. Ketamine is classically described as an NMDA antagonist. Ketamine's dissociative effects, however, are thought to be mediated by increased glutamate release via a pathway not dependent on NMDA receptors. Lamotrigine, on the other hand, is known to reduce cortical glutamate release. Conclusion. Lamotrigine reduces the glutamate release needed to mediate ketamine's dissociative anaesthesia. This is important knowledge for anaesthesiologists in the emergency room where ketamine is often administered to unstable patients.