OpenMed/multicare-articles huggingface dataset:
A conservative treatment for eosinophilic cystitis
Authors: Franco Alchiede Simonato, Nicola Pavan, Mirko Pinelli, Gabriele Tulone, Rosa Giaimo, Anna Martorana, Alchiede Simonato
Journal: IJU Case Rep (2022)
Keywords: conservative therapy, eosinophilic cystitis, hematuria, hyperbaric therapy, hypereosinophilic syndrome
MeSH terms: Case Reports

Introduction:
Eosinophilic cystitis is a rare condition which causes common symptoms and may mimic other conditions. Eosinophilic cystitis has several causes such as hypereosinophilic syndrome, inflammatory diseases, neoplasia, parasites or fungal infection, IgE-related diseases, Drug Reaction and Eosinophilia and Systemic Symptoms (DRESS) syndrome, or Churg-Strauss syndrome. Therefore, differential diagnosis is difficult.
Case presentation:
We report the case of a middle-aged man affected by eosinophilic cystitis with persistent hematuria and other peculiar symptoms that may be brought back to hypereosinophilic crisis.
Conclusion:
Conservative approach is preferred, avoiding radical cystectomy rather than corticosteroid, antihistaminic and second line therapy. Hyperbaric therapy is an innovative approach for severe relapsing gross hematuria without specific literature and should be studied for further indications.
Left ventricular free wall impeding rupture in post-myocardial infarction period diagnosed by myocardial contrast echocardiography: case report
Authors: Maria Luciana Zacarias Hannouche da Trindade, Jeane Mike Tsutsui, Ana Clara Tude Rodrigues, Márcia Azevedo Caldas, José Antônio Franchini Ramires, Wilson Mathias Junior
Journal: Cardiovasc Ultrasound (2006)
MeSH terms: Echocardiography, Heart Ventricles / diagnostic imaging, Myocardial Infarction / complications, Myocardial Infarction / diagnostic imaging, Ventricular Septal Rupture / diagnostic imaging, Ventricular Septal Rupture / etiology, Case Reports, Humans, Male, Middle Aged

Background:
Left ventricular free wall rupture occurs in up to 10% of the in-hospital deaths following myocardial infarction. It is mainly associated with posterolateral myocardial infarction and its antemortem diagnosis is rarely made. Contrast echocardiography has been increasingly used for the evaluation of myocardial perfusion in patients with acute myocardial infarction, with important prognostic implications. In this case, we reported its use for the detection of a mechanical complication following myocardial infarction.
Case presentation:
A 50-year-old man with acute myocardial infarction in the lateral wall underwent myocardial contrast echocardiography for the evaluation of myocardial perfusion in the third day post-infarction. A perfusion defect was detected in lateral and inferior walls as well as the presence of contrast extrusion from the left ventricular cavity into the myocardium, forming a serpiginous duct extending from the endocardium to the epicardial region of the lateral wall, without communication with the pericardial space. Magnetic resonance imaging confirmed the diagnosis of impending rupture of the left ventricular free wall. While waiting for cardiac surgery, patient presented with cardiogenic shock and died. Anatomopathological findings were consistent with acute myocardial infarction in the lateral wall and a left ventricular free wall rupture at the infarct site.
Conclusion:
This case illustrates the early diagnosis of left ventricular free wall rupture by contrast echocardiography. Due to its ability to be performed at bedside this modality of imaging has the potential to identify this catastrophic condition in patients with acute myocardial infarction and help to treat these patients with emergent surgery.
Emergent pulmonary embolectomy and advanced glioblastoma multiforme
Authors: Michael S Firstenberg, Danielle Blais, Erik Abel, Herbert B Newton, Juan Crestanello
Journal: Case Rep Med (2010)
MeSH terms: Case Reports

Pulmonary emboli are frequent causes of morbidity and mortality in patients with brain tumors. Treatment options are limited in these complex patients. We report a case of successful acute pulmonary embolectomy in a patient with an advanced brain cancer.
Left Atrial Mass Invasion from Pulmonary Neoplasm Extension via the Right Upper Pulmonary Vein Presenting as Ipsilateral Stroke
Authors: Piercarlo Ballo, Raffaele Laureano, Mariapia Briganti, Maria Teresa Passaleva, Fiorella Piani, Cecilia Piga, Stefano Tatini, Giovanni Maria Santoro
Journal: Case Rep Med (2016)

Left atrial invasion by lung cancer via haematogenous pathways is a relatively uncommon but potentially life-threatening event. While several cardiac complications of cardiac involvement have been previously described, the evolution towards cerebral stroke has been rarely reported. In this case report, we describe an atypical case of haematogenous metastatic invasion of the left atrium from pulmonary neoplasm extension presenting as an ipsilateral stroke whose ASCO classification changed during the clinical management.
Case report: Unusual patient with dermatomyositis associated with SARS-CoV-2 infection
Authors: Joanna Niedzielska, Monika Chaszczewska-Markowska, Justyna Chojdak-Łukasiewicz, Jakub Berezowski, Seema Kalra, Przemysław Jazwiec
Journal: Front Neurol (2023)
Keywords: covid-19, sars-cov-2, dermatomyositis, extrapulmonary manifestation, neurological complication
MeSH terms: Case Reports

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak is a major challenge for clinicians. SARS-CoV-2 infection results in coronavirus disease 2019 (COVID-19), and it is best known for its respiratory symptoms. It can also result in several extrapulmonary manifestations such as neurological complications potentially experienced during the course of COVID-19. The association of dermatomyositis (DM) with COVID-19 pathogenesis has not been well-studied. This study aimed to present a previously healthy 37-year-old man, a soldier by profession, with symptoms of DM on the 4th day from the onset of COVID-19. The patient presented DM symptoms with both skin and muscle manifestations. The patient suffered from cough, fever, and fatigue to begin with, and reverse-transcription polymerase chain reaction (RT-PCR) reported positive for SARS-CoV-2 infection. The laboratory findings showed, intra alia, elevated muscle enzymes CK 8253 U/l (N: <145 U/l), a positive test for myositis-specific autoantibodies (anti-Mi-2), electrodiagnostic tests exhibited features of myopathy, with the presence of muscle and skin symptoms. The patient improved with corticosteroids and immunosuppressive agent therapy. In summary, the association between COVID-19 and the development of multi-system autoimmune disorders such as DM remains unclear. Nevertheless, viral infections such as SARS-CoV-2 may likely serve as a trigger.
Primary retroperitoneal paraganglioma simulating a pancreatic mass: a case report and review of the literature
Authors: Guillermo Sangster, Daniel Do, Carlos Previgliano, Benjamin Li, Delecia LaFrance, Maureen Heldmann
Journal: HPB Surg (2010)
MeSH terms: Pancreatic Neoplasms / diagnosis, Paraganglioma / diagnosis, Retroperitoneal Neoplasms / diagnosis, Case Reports, Review, Abdominal Pain / etiology, Biopsy, Fine-Needle, Carcinoma, Renal Cell / diagnosis, Carcinoma, Renal Cell / surgery, Diagnosis, Differential, Frozen Sections, Humans, Immunohistochemistry, Kidney Neoplasms / diagnosis, Kidney Neoplasms / surgery, Male, Middle Aged, Neoplasms, Second Primary / diagnosis, Neoplasms, Second Primary / surgery, Paraganglioma / complications, Paraganglioma / radiotherapy, Positron-Emission Tomography, Rare Diseases, Retroperitoneal Neoplasms / complications, Retroperitoneal Neoplasms / radiotherapy, Tomography, X-Ray Computed

Paragangliomas are extra-adrenal tumors of the autonomic nervous system and may be found within the skull base, neck, chest, and abdomen. When presenting within the abdominal cavity, they may arise as a primary retroperitoneal neoplasm and can mimic vascular malformations or other conditions related to specific retroperitoneal organs such as the pancreas, kidneys, or adrenals. Retroperitoneal paragangliomas are mostly benign with good prognosis; however, they can present with abdominal pain, palpable mass, or hypertensive episodes. Patients should be initially evaluated with catecholamine levels, followed by computed tomography or magnetic resonance imaging to locate the primary lesion. Surgical excision remains the mainstay of treatment, although advanced disease and proximity to vital organs can make excision difficult or impossible. This case report describes a patient who initially underwent work up for a suspected pancreatic head mass which was discovered to be a retroperitoneal paraganglioma by frozen section.
Laparoscopic Adnexectomy for Ovarian Torsion during Late Pregnancy: Case Report of a Non-Conservative Treatment and Literature Analysis
Authors: Jean Bouquet de Joliniere, J B Dubuisson, F Khomsi, A Fadhlaoui, G Grant, N Ben Ali, A Major, A Feki
Journal: Front Surg (2017)
Keywords: adnexectomy, laparoscopy, ovarian torsion, pregnancy, ultrasound
MeSH terms: Case Reports

Diagnosis of adnexial torsion is difficult during pregancy (1). The time of decision and laparoscopy is that of the risk of necrosis of the adnexa and, therefore, of the ovarian prognosis. The loss of an ovary can compromise the following fertility. Even if concerns related to laparoscopy in pregnant patients include a limited surgical field, with a risk of uterine injury and negative fetal effects of CO2 insufflation. Evidence base suggests that minimally invasive surgery can be safe and better than laparotomy for management of adnexal masses during late pregnancy with good postoperative and obstetric outcomes. If for most authors laparoscopy appears to become the best approach for ovarian torsion during pregnancy (2), nonetheless, the ideal surgical laparoscopic approach of adnexa in late pregnancy remains controversial. Since there is no technical gold standard to overcome surgical difficulties which could make laparoscopic procedures as real challenge in patients in second and third trimester (3); at least, in case of radical and non-conservative treatment, the risk for a first trimester of pregnancy is to remove the corpus luteum (1).
A Novel Cost-Effective Technique for Speedy Resolution of Infantile Umbilical Hernia: Ammannaya's Technique
Authors: Ganesh Kumar K Ammannaya, Ninada Sripad
Journal: Case Rep Surg (2019)
MeSH terms: Case Reports

Umbilical hernia in the infant is common and resolves in majority of the cases by 6 years of age. Observation till this age and surgery in the event of persistence are the widely followed management strategies. Trusses, taping, and adhesive strapping have been tried to achieve speedy resolution with variable success and a significant incidence of skin complications. We present a novel, simple, easily reproducible, and highly cost-effective technique to achieve complete resolution of infantile umbilical hernia in a span of 8 weeks, with no skin complications.
Ultrasound guided lipofilling as a suggested method for implant salvage in implant based breast reconstruction: A case report
Authors: Tarek Hashem, Amira Radwan, Maged Yousry
Journal: Int J Surg Case Rep (2019)
Keywords: breast implants, breast reconstruction, case report, implant exposure, lipofilling

Background:
Implant based reconstruction is one of the well-established methods to restore shape and volume after total mastectomy. Exposure of an implant is a serious complication that could lead to failure of the whole process of breast reconstruction. There are no uniform guidelines on the management of such complication. Several methods have been described including antibiotic irrigation, implant replacement and flap coverage. This case report describes the use of ultrasound guided lipofilling for implant salvage in case of an exposed non-infected implant.
Case presentation:
A 29-year-old patient with T3N1 post neoadjuvant chemotherapy breast cancer underwent skin sparing mastectomy and immediate subpectoral implant based reconstruction. She presented a week post hospital discharge with an exposed non infected silicone implant. Antibiotic irrigation and secondary sutures were done with satisfactory wound healing within eight days. However, ultrasound examination revealed a sizeable area where the implant was in direct contact with the skin. Utrasound guided lipofilling was done in the same setting as contralateral mastopexy to achieve symmetry. The patient had a smooth postoperative course. She was referred to radiation therapy department where she received adjuvant chest wall irradiation according to her pathological result. Follow up after radiation therapy by clinical and ultrasound examination revealed no implant related complications.
Conclusion:
Lipofilling is a very useful tool that could help in cases of an uninfected exposed implant. It could also be used primarily as an adjunct procedure to implant based reconstruction to optimize the outcome.
Mental Health Technologies: Designing With Consumers
Authors: Simone Orlowski, Ben Matthews, Niranjan Bidargaddi, Gabrielle Jones, Sharon Lawn, Anthony Venning, Philippa Collin
Journal: JMIR Hum Factors (2016)
Keywords: design thinking, mental health, participatory design, technology

Despite growing interest in the promise of e-mental and well-being interventions, little supporting literature exists to guide their design and the evaluation of their effectiveness. Both participatory design (PD) and design thinking (DT) have emerged as approaches that hold significant potential for supporting design in this space. Each approach is difficult to definitively circumscribe, and as such has been enacted as a process, a mind-set, specific practices/techniques, or a combination thereof. At its core, however, PD is a design research tradition that emphasizes egalitarian partnerships with end users. In contrast, DT is in the process of becoming a management concept tied to innovation with strong roots in business and education. From a health researcher viewpoint, while PD can be reduced to a number of replicable stages that involve particular methods, techniques, and outputs, projects often take vastly different forms and effective PD projects and practice have traditionally required technology-specific (eg, computer science) and domain-specific (eg, an application domain, such as patient support services) knowledge. In contrast, DT offers a practical off-the-shelf toolkit of approaches that at face value have more potential to have a quick impact and be successfully applied by novice practitioners (and those looking to include a more human-centered focus in their work). Via 2 case studies we explore the continuum of similarities and differences between PD and DT in order to provide an initial recommendation for what health researchers might reasonably expect from each in terms of process and outcome in the design of e-mental health interventions. We suggest that the sensibilities that DT shares with PD (ie, deep engagement and collaboration with end users and an inclusive and multidisciplinary practice) are precisely the aspects of DT that must be emphasized in any application to mental health provision and that any technology development process must prioritize empathy and understanding over innovation for the successful uptake of technology in this space.
Balancing Therapy with Thrombopoietin Receptor Agonists and Splenectomy in Refractory Immune Thrombocytopenic Purpura: A Case of Postsplenectomy Thrombocytosis Requiring Plateletpheresis
Authors: Jacquelyn Zimmerman, Kelly J Norsworthy, Robert Brodsky
Journal: Case Rep Hematol (2016)

Immune thrombocytopenic purpura (ITP) causes thrombocytopenia through the autoimmune destruction of platelets. Corticosteroids remain the first line of therapy, and traditionally splenectomy has been the second. While the availability of thrombopoietin receptor agonists (TPO-RAs) has expanded treatment options, there is little data for the ideal management of these agents in preparation for splenectomy. Thrombocytosis has been reported after splenectomy in patients treated with TPO-RA preoperatively, with one prior case requiring plateletpheresis for symptomatic thrombocytosis. We present a case report and review of the literature pertaining to this complication and provide recommendations for preventing postsplenectomy thrombocytosis in ITP patients on TPO-RAs.
IgG4 Related Lung Disease
Authors: Mihir Patel, Beena Kumar, My Linh Diep, Deepali Nandurkar
Journal: Can Respir J (2016)
MeSH terms: Immunoglobulin G, Lung Diseases / immunology, Case Reports, Aged, Female, Humans, Lung Diseases / diagnostic imaging, Immunoglobulin G

IgG4 related disease is a poorly understood immune mediated condition. Lung involvement is rare and difficult to diagnose and can mimic primary lung malignancy on imaging. A patient who was found to have an incidental lung lesion with risk factors for primary pulmonary malignancy is reported.
Case report: Clinical features and prognosis of two Infants with rhabdomyosarcoma of the tongue
Authors: Peiyi Yang, Na Xu, Yan Su, Chao Duan, Shengcai Wang, Libing Fu, Tong Yu, Ruolan Guo, Xiaoli Ma
Journal: Front Oncol (2023)
Keywords: case report, infant, spindle cell rhabdomyosarcoma, susceptibility gene, tongue
MeSH terms: Case Reports

Background:
Rhabdomyosarcoma (RMS) is the most common soft tissue tumor in children, and its most common pathological types include embryonal RMS and alveolar RMS. In contrast, spindle cell RMS (SRMS) is a rare type. Moreover, the tongue is a rare primary site of RMS, and infancy is a rare age at onset.
Case presentation:
Two infants were diagnosed with lingual RMS at 3 and 5 months after birth, respectively, and were admitted to Beijing Children's Hospital. The pathological type in both cases was SRMS. Both were classified as low-risk and were treated with surgery and chemotherapy. Case 1 was in complete remission at the latest follow-up, and Case 2 had a relapse 10 months after stopping chemotherapy, achieving complete remission after the multimodal treatment of chemotherapy, surgery, and radiotherapy. The venous blood gene test of the two infants did not indicate a pathogenic mutation or a possible pathogenic mutation related to RMS. In Case 1, variants of the CDK4 and BRCA1 genes, both with unknown significance and a possible relation to RMS, were detected. In Case 2, three gene variants of unknown significance that were possibly associated with RMS-TRIP13, APC, and RAD54L-were identified.
Conclusion:
Lingual RMS in infants is rare. Its clinical manifestations lack specificity, and early recognition is complex. The success and timing of local treatment are important prognostic factors. Genetic testing may be helpful for the early detection of tumor susceptibility and the estimation of prognosis.
Primary retroperitoneal mucinous cystadenocarcinoma: report of two cases
Authors: David Cantú de León, Delia Pérez-Montiel, José Chanona-Vilchis, Alfonso Dueñas-González, Verónica Villavicencio-Valencia, Gladys Zavala-Casas
Journal: World J Surg Oncol (2007)
MeSH terms: Cystadenocarcinoma, Mucinous / pathology, Retroperitoneal Neoplasms / pathology, Case Reports, Adult, Cystadenocarcinoma, Mucinous / diagnosis, Female, Humans, Retroperitoneal Neoplasms / diagnosis, Young Adult

Background:
Retroperitoneal cystadenocarcinomas are rare lesions, the majority of cases presented as one-patient reports.
Methods:
We present two cases of retroperitoneal cystadenocarcinoma, both in women of reproductive age: one with aggressive behavior, and the remaining case, with a more indolent clinical evolution.
Results:
One case presented as pelvic tumor, was treated with surgical resection of the disease, but manifested with recurrent disease a few months later despite use of chemotherapy. The second case involved a patient with diagnosis of abdominal tumor; during laparotomy, a retroperitoneal tumor was found and was totally removed. At follow-up, the patient is disease-free with no other treatment.
Conclusion:
The behavior and treatment of retroperitoneal cystadenocarcinoma are controversial. We suggest aggressive surgery including radical hysterectomy and bilateral salpingoopherectomy with adjuvant chemotherapy in these cases.
Case report: Detection of anti-bullous pemphigoid antigen 180 antibodies in a patient with Behçet's disease
Authors: Dario Didona, Antonio Manuel Sequeira Santos, Tomas Cunha, Julia Hinterseher, Jacqueline Kussini, Michael Hertl
Journal: Front Med (Lausanne) (2022)
Keywords: behçet’s disease, autoantibodies, bullous pemphigoid, diagnosis, epitope spreading
MeSH terms: Case Reports

Behçet's disease (BD) is a systemic inflammatory disease of unknown etiology. BD is characterized by relapsing oral and genital ulcers, several different cutaneous features, relapsing bilateral uveitis, and involvement of internal organs, showing vascular, gastrointestinal, and neurological manifestations. Serologically, BD is not characterized by disease-specific autoantibodies. In fact, only laboratory markers of inflammation, such as C-reactive protein, may be increased in association with increased disease activity. Bullous pemphigoid (BP) is an autoimmune disease characterized mainly by tense blisters and urticaria-like plaques on the skin. In addition, BP can involve oral mucosa in up to 20% of patients. Patients with BP show serum IgG autoantibodies against BP antigen 180 (BP180) and/or BP antigen 230 (BP230). Tissue-bound autoantibodies can be visualized as linear IgG staining along the basement membrane by direct immunofluorescence microscopy. In this report, we first described a young patient with BD who showed IgG autoantibodies against BP180 without developing blisters or urticaria-like plaques.
Fulminant Disseminated Intravascular Coagulation as Initial Presentation of BRAF-Mutated Melanoma
Authors: Jeremy Chuang, An Uche, Rohan Gupta, Kim Margolin, Phyllis Kim
Journal: Case Rep Oncol Med (2019)
MeSH terms: Case Reports

Acute disseminated intravascular coagulation (DIC) is a pathological process involving dysfunction of the coagulation cascade. In this case report, we discuss a 33-year-old woman with BRAF V600E-mutated metastatic melanoma who presented in fulminant DIC with concurrent hemorrhagic and thrombotic manifestations and discuss the patient's brief response to combination therapy. In our discussion, we highlight the current understanding of DIC and also identify opportunities for future research to elucidate the genetic aberrations in melanoma that may result in treatment resistance to combination therapy.
Intracranial metastatic neuroblastoma treated with gamma knife stereotactic radiosurgery: report of two novel cases
Authors: Nathan C Rowland, Jennifer Andrews, Daxa Patel, David V Laborde, Adam Nowlan, Bradley George, Claire Mazewski, Andrew Reisner, Howard M Katzenstein
Journal: Case Rep Neurol Med (2012)
MeSH terms: Case Reports

Intracranial metastasis of neuroblastoma (IMN) is associated with poor survival. No curative therapy for the treatment of IMN currently exists. Unfractionated radiotherapy may be beneficial in the treatment of IMN given the known radiosensitivity of neuroblastoma as well as its proclivity to metastasize as discrete lesions. We present two patients with IMN treated with Gamma Knife stereotactic radiosurgery (SRS). Single-fraction radiotherapy yielded temporary reduction of tumor burden and stability of disease in both patients. SRS may be a useful palliative tool in the treatment of IMN and expands the overall treatment options for this disease.