OpenMed/multicare-articles huggingface dataset:
Digital Workflow for Indirect Bonding with 2D Lingual Brackets: A Case Report and Procedure Description
Authors: Federico Rosti, Maria Francesca Sfondrini, Davide Bressani, Marina Consuelo Vitale, Paola Gandini, Andrea Scribante
Journal: Case Rep Dent (2019)
MeSH terms: Case Reports

Objective:
During orthodontic therapy, accuracy in bonding procedures makes it easier to correct tooth alignment by decreasing the need for midcourse corrections by changing bracket positions. Indirect bonding allows the transfer of the appliance components from model casts to patient's teeth potentially meaning shorter appointments for bracket bonding and rebonding and best comfort during chairside practice. At the same time, there has been a steady increase in requests for invisible lingual orthodontic treatment.
Clinical considerations:
Accordingly, the aim of the present report is to illustrate the workflow to realize a complete digital indirect bonding for lingual brackets (2D, Forestadent). The procedure starts with intraoral digital scans, digital 3D model, and virtual bracket positioning, ending with the realization of a CAD-CAM prototyped transfer tray. A 3D intraoral scanner (True Definition, 3M) is used to create digital scans and digital models. A virtual bracket positioning is performed using software (NemoCast, Dentaurum), and a prototyped transfer tray is created by a CAD-CAM device. 2D lingual brackets were positioned inside the tray, so the appliance was bonded to the dental surface using light curing adhesive resin.
Conclusions:
During orthodontic treatment, CAD/CAM technology could help clinicians. Computer-constructed transfer trays can reduce clinician error and improve the everyday workflow in the office.
Case Report: Anlotinib Combined With Sintilimab as Third-Line Treatment in a Metastatic Urothelial Bladder Carcinoma Patient With FGFR3 Mutation
Authors: Jian-Zhou Cao, Wei Wu, Jin-Feng Pan, Hong-Wei Wang, Jun-Hui Jiang, Qi Ma
Journal: Front Oncol (2021)
Keywords: anlotinib, immunotherapy, metastatic urothelial bladder carcinoma, sintilimab, targeted therapy
MeSH terms: Case Reports

We report on a case of metastatic urothelial bladder carcinoma (mUBC) treated with anlotinib combined with sintilimab. A 69-year-old male was diagnosed with non-muscle invasive bladder cancer (NMIBC). He received transurethral resection of bladder tumor (TURBT) and intravesical gemcitabine chemotherapy. After the patients' cancer progressed to mUBC, cisplatin-based chemotherapy (gemcitabine combined with cisplatin, GC) was performed to this patient as first line therapy for four cycles. However, the disease progressed again within 6 months. Local radiotherapy was performed on the metastatic lesions, and after radiotherapy, the patient received anti-PD-1 antibody (sintilimab 200 mg, q3w)combined with Albumin-bound (Nab)-paclitaxel (100 mg, qw) as the second-line therapy, but the patient's cancer was still observed to be progressing. Molecular characterization confirmed the presence of FGFR3 mutations in the patient. Anlotinib was recommended to this patient. After the patient was fully informed and he was aware of off-label use of the drug, then, Nab-paclitaxel was replaced by anlotinib (10 mg D1-14, q3w) and sintilimab infusions were maintained for every 3 weeks. Partial response (PR) was observed through imaging examinations and stable disease (SD) was observed for more than 11 months; the patient's quality of life also improved. This case suggested that anlotinib combined with sintilimab may be a safe and effective choice in the treatment of mUBC in patients with FGFR3 mutations.
Split right coronary artery with split posterior descending artery
Authors: Niraj Nirmal Pandey, Aprateem Mukherjee, Vineeta Ojha, Raghav Bansal, Sanjeev Kumar
Journal: J Cardiovasc Thorac Res (2023)
Keywords: cardiac-gated imaging techniques, computed tomography angiography, coronary artery disease, right coronary artery
MeSH terms: Case Reports

We report a case of an 87-year-old man where coronary CT angiography incidentally demonstrated a "split" right coronary artery (RCA) featuring a "split" posterior descending artery. This case focusses on the morphological description of this variant as well as its differentiation from a "dual" or "duplicated" RCA.
A case of caudal regression syndrome: walking or sitting?
Authors: Irem Bicakci, Selin Turan Turgut, Bekir Turgut, Afitap Icagasioglu, Zeliha Egilmez, Yasemin Yumusakhuylu
Journal: Pan Afr Med J (2014)
Keywords: caudal regression syndrome, congenital malformation, knee flexion contracture, maternal diabetes, sacral agenesis
MeSH terms: Contracture / congenital, Lower Extremity Deformities, Congenital / diagnosis, Muscle Hypotonia / congenital, Spinal Cord / abnormalities, Case Reports, Child, Preschool, Female, Humans, Hydronephrosis / etiology, Kidney / abnormalities, Pregnancy, Pregnancy in Diabetics, Thoracic Vertebrae / abnormalities, Urinary Bladder, Neurogenic / etiology, Vesico-Ureteral Reflux / etiology

Caudal regression syndrome (CRS) is a congenital disorder which is seen vertebral anomalies in varying degrees from lower thoracic spineto the level of the coccyx. We present a case of CRS which is not intended operation for orthopedic deformities considering functionality. 2, 5 year-old girl referred to our clinic with complaints about walking disability, knee and foot deformities. Patient's mother with unregulated diabetes did not have a history of drug use, radiation exposure and serious illness during pregnancy. Diagnosis had been put during antenatal follow-ups. On physical examination, her lower extremities were hypoplastic and had no muscle activity. Her hips were flexed and abducted, but did not have contractures. Her knees had 75 degrees of flexion contractures with popliteal webs and feet had equinovarus deformity. Frog belly was present due to abdominal muscles weakness. Also hypoplasic labia majora has been identified. In lumbar MRI, spinal cord was terminated at 6th thoracic (T6) vertebrae and the last solid vertebrae level was at T10. Patient who has been following by urology with clean intermittent catheterization had also severe urological problems including horseshoe kidney, neurologic bladder, vesico-ureteral reflux and grade 2 hydronephrosis. Orthopedic consultation was made for her deformities. They decided that ambulation unexpected patient's knee flexion contractures were helping sitting balance. Because of this operation was not considered. Prognosis, treatment options, strength exercises for upper extremities, skin care were told to parents and patient was taken to follow. CRS is a rare congenital abnormality which is associated with orthopedic deformities, as well as urological, anorectal and cardiac malformations. Treatment requires a multidisciplinary approach. It should not be forgotten that purpose of rehabilitation is not to correct all deformities but increase the functionality of everyday life.
Gastric trichobezoar causing intermittent small bowel obstruction: report of a case and review of the literature
Authors: Nicole G Coufal, Akash P Kansagra, Jay Doucet, Jeanne Lee, Raul Coimbra, Vishal Bansal
Journal: Case Rep Med (2011)
MeSH terms: Case Reports

We report the unusual case of a 45-year-old woman who presented with multiple episodes of small bowel obstruction. Initial exploratory lap-roscopy did not reveal an etiology of the obstruction. Subsequent upper endoscopy identified a non-obstructing gastric trichobezoar which could not be removed endoscopically but was not thought to be responsible for the small bowel obstruction given its location. One week postoperatively, the patient experienced recurrence of small bowel obstruction. Repeat endoscopy disclosed that the trichobezoar was no longer located in the stomach and upon repeat laparotomy was extracted from the mid-jejunum. In the following 8 months, the patient had no further episodes of small bowel obstruction. Consequently, gastric bezoars should be included in the differential diagnosis of recurrent small bowel obstruction.
HPV Type 6 and 18 Coinfection in a Case of Adult-Onset Laryngeal Papillomatosis: Immunization with Gardasil
Authors: Virginia Fancello, Andrea Melis, Andrea Fausto Piana, Paolo Castiglia, Andrea Cossu, Giovanni Sotgiu, Corrado Bozzo, Emma Victoria King, Francesco Meloni
Journal: Case Rep Otolaryngol (2015)

Laryngeal papillomatosis (LP) is a rare human papillomavirus (HPV) related disease that often requires multiple surgical interventions and residual impairment of voice is almost inevitable. We report the case of a patient with adult onset recurrent LP, showing moderate dysplasia and coinfection with HPV types 6 and 18. The tetravalent HPV vaccine Gardasil was prescribed off label, with the aim of triggering an immunogenic response and consequently reducing the probability of further recurrences. The patient was followed for 9 months with no sign of relapse of his LP. The postexposure use of the anti-HPV vaccine could represent a promising therapeutic agent in established LP. Unfortunately, the potential efficacy of this new therapeutic option in this situation has been suggested only by isolated case reports. Further controlled studies, with a longer follow-up and a larger sample size, are needed to assess efficacy of Gardasil in LP.
Gallstone Ileus in a Young Patient: A Clinical Case Report and Literature Review
Authors: Milton A Muñoz-Leija, Marion C Alemán-Jiménez, Alejandro Quiroga-Garza, Rodrigo E Elizondo-Omaña, Santos Guzmán-López
Journal: Cureus (2023)
Keywords: abdominal pain, bowel obstruction, gallbladder, gallstone ileus, surgical approach
MeSH terms: Case Reports

Gallstone ileus is a rare presentation of gallbladder disease. It is mostly encountered in female and elderly patients. It occurs when a stone causes a fistula between the gallbladder and the intestinal lumen. More than half of the patients do not have a history of biliary disease. Surgical intervention is still considered the best treatment option; however, the best choice between one-stage and two-stage surgery is still unknown. We present a gallstone Ileus case in a patient with uncommon epidemiological characteristics: a 28-year-old male Hispanic patient without a gallbladder disease history.
Cricoarytenoiditis as an initial manifestation of systemic lupus erythematosus
Authors: Jean-Michel Hougardy, Nicolas Roper, Alain Michils, Muhammad S Soyfoo
Journal: Case Rep Rheumatol (2011)
MeSH terms: Case Reports

Systemic lupus erythematosus (SLE) is a chronic inflammatory disease encompassing a broadened spectrum of clinical manifestations. Vocal cords involvement in SLE is not a frequent entity but can be life threatening if not treated. We hereby report the case of a patient presenting with cricoarytenoiditis and vocal cord dysfunction revealing SLE.
Use of Foscarnet Therapy for EBV Infection following Control of PTLD with Enhancement of Cellular Immunity in a Lung-Transplant Recipient
Authors: Kamyar Afshar, A Purush Rao, Vipul Patel, Kevin Forrester, Sivagini Ganesh
Journal: J Transplant (2011)
MeSH terms: Case Reports

Posttransplant lymphoproliferative disorder (PTLD) is a serious complication following solid organ transplantation with an annual incidence rate of 3-5% in lung-transplant recipients. Pathogenesis indicates a strong association with functional over-immunosuppression and EBV infection. Clinical improvement is generally observed with reduction in immunosuppression intensity alone. We present a case of a 24-year-old woman with EBV-associated PTLD following lung transplant where decreasing the immunosuppression improved PTLD but was ineffective against controlling the EBV infection. Foscarnet in combination with immunoglobulins was successfully administered to cause a remission of the EBV infection. This is the second case reported of a persistent EBV infection after reducing immunosuppression levels and evidence of PTLD remission that required foscarnet for EBV infection control.
Immediate provisionalization and nonfunctional loading of a single implant in the maxillary esthetic zone: a clinical presentation and parameters for consideration
Authors: Konstantinos X Michalakis, Christos D R Kalpidis, Yvone Kirmanidou, Hiroshi Hirayama, Pasquale Lino Calvani, Argiris L Pissiotis
Journal: Case Rep Dent (2013)

Restoration of single tooth loss with implant supported prosthesis is now considered a highly predictable treatment. However, the maxillary anterior region still presents a challenge for both the prosthodontist and the periodontist because of the inherent difficulties encountered in the provisionalization and harmonic incorporation of the definitive prosthesis into patient's dentogingival complex. This paper presents a clinical case of a single implant placed immediately after the extraction of a maxillary central incisor, followed by immediate provisionalization and nonfunctional loading. The surgical and the restorative techniques are described, and the parameters of consideration for this approach are presented.
"Magic Bullet": Eccentric Macular Hole as a Complication from Dexamethasone Implant Insertion
Authors: Logan Christensen, Riley Sanders, Jeffrey Olson
Journal: Case Rep Ophthalmol Med (2016)

Introduction. Intravitreal drug injections and implants are generally safe but do carry some risk, from both the procedure itself and adverse effects of the medications. We report a case of an eccentric macular hole after dexamethasone implant (Ozurdex®) administration. Ex vitro force testing was performed to evaluate dexamethasone implant injection force. Methods. Five dexamethasone implant (Ozurdex) applicators were placed 16 mm from a force plate and the force of the injected dexamethasone pellet was recorded in Newtons. Four dexamethasone implant applicators were placed 16 mm from a force plate in a basic saline solution and the force of the pellet was recorded. Results. Average maximum force in air was 0.77 N and 0.024 N in a basic saline solution (BSS). Conclusion. We present a case report of an eccentric macular hole after dexamethasone implant administration. We hypothesize a mechanical injury to the retina during insertion caused the macular hole. Force testing done in air demonstrated sufficient force from the pellet injection to cause retinal damage though injections done in BSS showed reduced forces.
Impacts of population structure and analytical models in genome-wide association studies of complex traits in forest trees: a case study in Eucalyptus globulus
Authors: Eduardo P Cappa, Yousry A El-Kassaby, Martín N Garcia, Cintia Acuña, Nuno M G Borralho, Dario Grattapaglia, Susana N Marcucci Poltri
Journal: PLoS One (2013)
MeSH terms: Eucalyptus / genetics, Genome-Wide Association Study, Models, Theoretical, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Genes, Plant, Genetic Markers, Principal Component Analysis, Quantitative Trait Loci, Genetic Markers

The promise of association genetics to identify genes or genomic regions controlling complex traits has generated a flurry of interest. Such phenotype-genotype associations could be useful to accelerate tree breeding cycles, increase precision and selection intensity for late expressing, low heritability traits. However, the prospects of association genetics in highly heterozygous undomesticated forest trees can be severely impacted by the presence of cryptic population and pedigree structure. To investigate how to better account for this, we compared the GLM and five combinations of the Unified Mixed Model ( UMM ) on data of a low-density genome-wide association study for growth and wood property traits carried out in a Eucalyptus globulus population (n = 303) with 7,680 Diversity Array Technology (DArT) markers. Model comparisons were based on the degree of deviation from the uniform distribution and estimates of the mean square differences between the observed and expected p-values of all significant marker-trait associations detected. Our analysis revealed the presence of population and family structure. There was not a single best model for all traits. Striking differences in detection power and accuracy were observed among the different models especially when population structure was not accounted for. The UMM method was the best and produced superior results when compared to GLM for all traits. Following stringent correction for false discoveries, 18 marker-trait associations were detected, 16 for tree diameter growth and two for lignin monomer composition (S:G ratio), a key wood property trait. The two DArT markers associated with S:G ratio on chromosome 10, physically map within 1 Mbp of the ferulate 5-hydroxylase (F5H) gene, providing a putative independent validation of this marker-trait association. This study details the merit of collectively integrate population structure and relatedness in association analyses in undomesticated, highly heterozygous forest trees, and provides additional insights into the nature of complex quantitative traits in Eucalyptus.
Unilateral phrenic nerve lesion in Lyme neuroborreliosis
Authors: Marija Djukic, Jörg Larsen, Paul Lingor, Roland Nau
Journal: BMC Pulm Med (2013)
MeSH terms: Lyme Neuroborreliosis / complications, Lyme Neuroborreliosis / diagnosis, Peripheral Nervous System Diseases / microbiology, Phrenic Nerve / microbiology, Case Reports, Research Support, Non-U.S. Gov't, Aged, 80 and over, Diagnosis, Differential, Diaphragm / diagnostic imaging, Diaphragm / physiology, Fluoroscopy, Humans, Lyme Neuroborreliosis / physiopathology, Male, Peripheral Nervous System Diseases / diagnosis, Peripheral Nervous System Diseases / diagnostic imaging, Phrenic Nerve / physiology, Respiratory Mechanics / physiology

Background:
Among a variety of more common differential diagnoses, the aetiology of acute respiratory failure includes Lyme neuroborreliosis.
Case presentation:
We report an 87-years old huntsman with unilateral phrenic nerve palsy as a consequence of Lyme neuroborreliosis.
Conclusion:
Although Lyme neuroborreliosis is a rare cause of diaphragmatic weakness, it should be considered in the differential workup because of its potentially treatable nature.
Functional Antibody Responses Following Allogeneic Stem Cell Transplantation for TP53 Mutant pre-B-ALL in a Patient With X-Linked Agammaglobulinemia
Authors: Menno C van Zelm, Marsus Pumar, Peter Shuttleworth, Pei M Aui, Joanne M Smart, Andrew Grigg, Julian J Bosco
Journal: Front Immunol (2019)
Keywords: btk, igg, x-linked agammaglobulinemia, allogeneic stem cell transplantation, pre-b-all, vaccination response
MeSH terms: Agammaglobulinemia / genetics, Genetic Diseases, X-Linked / genetics, Hematopoietic Stem Cell Transplantation, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / therapy, Tumor Suppressor Protein p53 / genetics, Case Reports, Research Support, Non-U.S. Gov't, Adult, Cyclosporine / therapeutic use, Graft vs Host Disease / prevention & control, Humans, Immunoglobulin A / blood, Immunoglobulin G / blood, Immunoglobulin M / blood, Immunosuppressive Agents / therapeutic use, Male, Prednisolone / therapeutic use, Transplantation Conditioning, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Immunosuppressive Agents, TP53 protein, human, Tumor Suppressor Protein p53, Cyclosporine, Prednisolone, Bruton type agammaglobulinemia

Patients with X-linked agammaglobulinemia (XLA) have failure of B-cell development with lack of immunoglobulin (Ig) production. While immunoglobulin replacement therapy (IgRT) is beneficial, XLA patients remain at risk for infections, structural lung damage, and rarely, neoplasia. Allogeneic stem cell transplantation (alloSCT) may offer a potential cure, but is associated with significant life-threatening complications. Here, we present a 25-year old XLA patient who developed pre-B acute lymphocytic leukemia (ALL) with somatic TP53 mutation, and treatment for this high-risk malignancy involved full myeloablative conditioning and a HLA-matched sibling alloSCT. Full donor chimerism was achieved for CD3+ and CD3- cell fractions. The patient remains in morphological and flow cytometric remission 14 months post-transplant, with late-onset oral GvHD requiring low dose prednisolone and cyclosporin. Following IgRT discontinuation at 4 months post-transplantation, humoral immunity was established within 14 months as reflected by normal numbers of total B cells, memory B cells, serum IgG, IgM, and IgA, and production of specific IgG responses to Prevenar-13 vaccination. This is only the second reported case of an XLA patient with pre-B-ALL, and the most detailed report of engraftment following alloSCT in XLA. Together with the two previous XLA cases treated with alloSCT, our report provides evidence for the potential for successful humoral reconstitution with alloSCT in patients with B-cell intrinsic antibody deficiency. These observations may be relevant given IgRT, while beneficial, remains an imperfect solution to long-term infectious complications.
Adnexal Torsion during Pregnancy after Oocyte In Vitro Maturation and Intracytoplasmic Sperm Injection Cycle
Authors: Simone Giulini, Giulia Dante, Susanna Xella, Antonio La Marca, Tiziana Marsella, Annibale Volpe
Journal: Case Rep Med (2010)
MeSH terms: Case Reports

We report a case of right adnexal torsion during pregnancy after an oocyte in vitro maturation and intracitoplasmic sperm injection cycle in patient with polycystic ovary syndrome. A 31-year-old woman with a typical clinical disorder of polycystic ovarian syndrome was included in an oocyte in vitro maturation program. Right adnexal torsion occurred two days after embryo transfer, and laparoscopy detorsion was successfully performed with preservation of adnexa. The patient had a full-term pregnancy and delivered a healthy infant at 40 weeks of gestation. To our knowledge this is the first report of adnexal torsion after an oocyte in vitro maturation and intracitoplasmic sperm injection program.
Osteoradionecrosis of the jaws triggered by dental implants placement: A case report
Authors: Jorge Toledano-Serrabona, Gabriela Párraga-Manzol, Mª Ángeles Sánchez-Garcés, Cosme Gay-Escoda
Journal: J Clin Exp Dent (2019)
MeSH terms: Case Reports

Background:
The decision-making process about how to rehabilitate edentulous osseous defects in patients with head and neck cancer history can be complex. Even though, endosseous dental implants could be considered to be the first choice for treating these patients, it is highly important to be aware of the complications that might occur. The aim of this report was to describe the clinical features of mandibular fracture after dental implants placement on a cancer irradiated patient and update the available information about this event.
Case report:
The case describes a 70-year-old man, with medical background of radiotherapy in jaw bones to treat a carcinoma in the floor of the mouth and later on in the soft palate and cheek. One week after dental implant surgery, the patient presented a mandibular osteoradionecrosis that healed in 8 months. A fracture on the right side of the body mandible was diagnosed one year after implant placement. Although several options were suggested in order to repair the fracture, the patient did not accept any further treatment despite the callus formation not being radiographically evident. The implant-supported prosthesis is functionally useful for more than 8 years of follow-up without significant problems.
Conclusions:
The implant treatment and management of oncologic irradiated patients require special considerations due to the risk of osteoradionecrosis and its possible complications, such as pathologic fracture. It is necessary to provide full information to the patient about risk factors and complications. Key words:Dental implants, mandibular fracture, osteoradionecrosis jaw, complications, fracture, cancer.