OpenMed/multicare-articles huggingface dataset:
A Novel Nontraumatic Gingival Retraction Method for a Single-Unit Crown Impression
Authors: Hozaifa Al-Nasser, Nabil Al-Houri, Anas Mouti, Heba Alajami
Journal: Case Rep Dent (2022)
MeSH terms: Case Reports

Until now, there have been three traditional options for gingival retraction procedures, mechanical, chemicomechanical, and surgical methods, which have a degree of trauma that varies according to the clinical experience. The gingival tissue may be very delicate and susceptible to recession if too much trauma was applied. This article describes a novel nontraumatic gingival retraction method, without cords, chemicals, surgery, or any special equipment.
A Comprehensive Discussion in Vaginal Cancer Based on Mechanisms, Treatments, Risk Factors and Prevention
Authors: Sumit Kumar Baral, Partha Biswas, Md Abu Kaium, Md Aminul Islam, Dipta Dey, Md Al Saber, Tanjim Ishraq Rahaman, A M, Talha Bin Emran, Md Nazmul Hasan, Mi-Kyung Jeong, Ihn Han, Md Ataur Rahman, Bonglee Kim
Journal: Front Oncol (2022)
Keywords: hpv type 16, carcinogenesis mechanisms, human papillomavirus (hpv) e6 and e7 proteins, postmenopausal, synchronous or metachronous, vaginal cancer
MeSH terms: Review

Vaginal cancer is a rare and uncommon disease that is rarely discussed. Although vaginal cancer traditionally occurs in older postmenopausal women, the incidence of high-risk human papillomavirus (HPV)-induced cancers is increasing in younger women. Cervical cancer cells contain high-risk human papillomavirus (HPV) E6 and E7 proteins and inhibiting HPV gene expression leads the cells to stop proliferating and enter senescence. As E6, and E7 protein promoted the carcinogenesis mechanism, and here not only regulate the cellular degradation of P53, and pRb but also enhances the cell proliferation along with E6 protein targets the p53 for breakdown and subsequently promote the apoptotic cell death, and DNA repair inhibition, that is indispensable to the continue the lifecycle of the HPV. As a synchronous or metachronous tumor, vaginal cancer is frequently found in combination with cervical cancer. It is uncertain what causes invasive female vaginal organ cancer. HPV type 16 is the most often isolated HPV type in female vaginal organ cancers. Due to cancer's rarity, case studies have provided the majority of etiologic findings. Many findings demonstrate that ring pessaries, chronic vaginitis, sexual behavior, birth trauma, obesity, vaginal chemical exposure, and viruses are all risk factors. Because of insufficient understanding and disease findings, we are trying to find the disease's mechanism with the available data. We also address different risk factors, therapy at various stages, diagnosis, and management of vaginal cancer in this review.
Calcific myonecrosis and the role of imaging in the diagnosis: a case report
Authors: Atsushi Okada, Masahito Hatori, Masami Hosaka, Munenori Watanuki, Eiji Itoi
Journal: Ups J Med Sci (2009)
MeSH terms: Calcinosis / pathology, Muscle, Skeletal / pathology, Case Reports, Calcinosis / diagnostic imaging, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Muscle, Skeletal / diagnostic imaging, Tomography, X-Ray Computed

Calcific myonecrosis is a rare posttraumatic complication characterized by the replacement of muscles of one or more compartments with central liquefaction and peripheral calcification. We report magnetic resonance imaging (MRI) and CT imaging features of calcific myonecrosis arising 43 years after trauma. A 62-year-old man presented with a slowly enlarging mass in the left lower leg. Plain radiographs revealed a soft tissue mass with extensive amorphous calcification. The middle third of the tibia and fibula were eroded. MRI demonstrated peripheral ring enhancement on postcontrast fat-suppressed T1-weighted images. Volume-rendered images extracting only the images of bone and vessels also showed many branches from the tibialis posterior and peroneal arteries around the bone defect. During the operation, bleeding continued heavily from the vessels penetrating the cortical bone of the tibia, from the posterior compartment, and from the branches of tibialis posterior artery. The total blood loss was approximately 2,400 milliliters. There may be a causal relationship between massive bleeding and the hypervascularity of this tumor as evidenced by MRI and volume-rendering CT studies.
Clopidogrel-Induced Severe Hepatitis: A Case Report and Literature Review
Authors: Hesam Keshmiri, Anuj Behal, Shawn Shroff, Charles Berkelhammer
Journal: Case Reports Hepatol (2016)

Clopidogrel is a commonly prescribed antiplatelet agent that carries a rare risk of hepatotoxicity. We describe a case of severe clopidogrel-induced hepatitis with liver biopsy assessment. Prompt recognition and withdrawal of the offending agent are imperative to prevent progression and potentially fatal liver injury.
Simultaneous bilateral spontaneous pneumothorax as the first manifestation of primary pulmonary MALT lymphoma
Authors: Asma Migaou, Nader Slama, Manel Njima, Asma Achour, Ahmed Ben Saad, Sarra Boukhris, Nesrine Fahem, Sabrine Dimassi, Adnene Laatiri, Saoussen Cheikh Mhammed, Naceur Rouatbi, Sameh Joobeur
Journal: Pan Afr Med J (2020)
Keywords: bilateral pneumothorax, malt lymphoma, organizing pneumonia, pneumothorax
MeSH terms: Lung Neoplasms / diagnosis, Lymphoma, B-Cell, Marginal Zone / diagnosis, Pneumothorax / etiology, Case Reports, Antineoplastic Combined Chemotherapy Protocols / administration & dosage, Chest Pain / etiology, Chest Tubes, Cyclophosphamide / administration & dosage, Doxorubicin / administration & dosage, Dyspnea / etiology, Female, Humans, Lung Neoplasms / pathology, Lung Neoplasms / therapy, Lymphoma, B-Cell, Marginal Zone / pathology, Lymphoma, B-Cell, Marginal Zone / therapy, Middle Aged, Prednisone / administration & dosage, Rituximab / administration & dosage, Vincristine / administration & dosage, R-CHOP protocol, Rituximab, Vincristine, Doxorubicin, Cyclophosphamide, Prednisone

Primary pulmonary lymphoma is a rare entity. Furthermore, simultaneous bilateral spontaneous pneumothorax (SBSP) is a very rare condition which is often related to therapeutic complications. We present, to the best of our knowledge, the first case of primary pulmonary mucosa associated lymphoid tissue (MALT) lymphoma revealed by SBSP. A 50-year-old female was diagnosed with organizing pneumonia. One month later, she presented with sudden chest pain and shortness of breath due to SBSP. Bilateral chest tubes were inserted. A scan- guided right lung biopsy led to the diagnosis of primary pulmonary MALT lymphoma. The patient was treated with R-CHOP chemotherapy. The association between lymphoma and pneumothorax is extremely rare, often related to therapeutic toxicity. We report the case of SBSP as the first manifestation of primary pulmonary MALT lymphoma.
Infected urachal remnants: an unusual presentation
Authors: Victor Hugo Ramos Pacheco, Yolanda Saldaña Dominguez, Alicia Maria Del Consuelo Cervantes Sánchez
Journal: BJR Case Rep (2016)
MeSH terms: Case Reports

The urachus is the remnant of the cloaca and allantois, and attaches the umbilicus to the bladder dome. Urachal anomalies are symptomatically identified during childhood. It rarely occurs in adults, making diagnosis difficult. We present and discuss the case of an infected patent urachus in a 30-year-old male.
Long-term effects of the gait treatment using a wearable cyborg hybrid assistive limb in a patient with spinal and bulbar muscular atrophy: a case report with 5 years of follow-up
Authors: Kensuke Iijima, Hiroki Watanabe, Yuichi Nakashiro, Yuki Iida, Michio Nonaka, Fumio Moriwaka, Shinsuke Hamada
Journal: Front Neurol (2023)
Keywords: gait treatment, spinal and bulbar muscular atrophy, walking endurance, walking symmetry, wearable cyborg hybrid assistive limb (hal)
MeSH terms: Case Reports

Background:
Spinal and bulbar muscular atrophy (SBMA) is a progressive neuromuscular degenerative disease characterized by the degeneration of lower motor neurons in the spinal cord and brainstem and neurogenic atrophy of the skeletal muscle. Although the short-term effectiveness of gait treatment using a wearable cyborg hybrid assistive limb (HAL) has been demonstrated for the rehabilitation of patients with SBMA, the long-term effects of this treatment are unclear. Thus, this study aimed to investigate the long-term effects of the continued gait treatment with HAL in a patient with SBMA.
Results:
A 68-year-old man with SBMA had lower limb muscle weakness and atrophy, gait asymmetry, and decreased walking endurance. The patient performed nine courses of HAL gait treatment (as one course three times per week for 3 weeks, totaling nine times) for ~5 years. The patient performed HAL gait treatment to improve gait symmetry and endurance. A physical therapist adjusted HAL based on the gait analysis and physical function of the patient. Outcome measurements, such as 2-min walking distance (2MWD), 10-meter walking test (maximal walking speed, step length, cadence, and gait symmetry), muscle strength, Revised Amyotrophic Lateral Sclerosis Functional Assessment Scale (ALSFRS-R), and patient-reported outcomes, were evaluated immediately before and after gait treatment with HAL for each course. 2MWD improved from 94 m to 101.8 m, and the ALSFRS-R gait items remained unchanged (score 3) for approximately 5 years. The patient could maintain walking ability in terms of gait symmetry, walking endurance, and independence walking despite disease progression during HAL treatment.
Conclusion:
The long-term gait treatment with HAL in a patient with SBMA may contribute to the maintenance and improvement of the gait endurance and ability to perform activities of daily living. The cybernics treatment using HAL may enable patients to relearn correct gait movements. The gait analysis and physical function assessment by a physical therapist might be important to maximize the benefits of HAL treatment.
Nivolumab Effective for Gastric and Lung Cancers but Not for Multiple Myeloma in a Multiple Primary Cancer Patient
Authors: Tsukasa Yasuda, Junji Hiraga, Michihiko Narita, Yoshimasa Tanikawa, Tomoyuki Tsuzuki
Journal: Case Rep Hematol (2021)
MeSH terms: Case Reports

The case of a 76-year-old man with multiple primary cancers that were treated with nivolumab is presented. Six years earlier, he was diagnosed with multiple myeloma (MM) and was treated with several chemotherapies. He was also diagnosed with gastric cancer with liver metastasis and primary lung cancer by upper gastrointestinal endoscopy and computed tomography (CT). Nivolumab treatment was given as third-line therapy, and it was effective for gastric and lung cancers. But MM worsened, and the patient died. There is no standard treatment for multiple primary cancers, and the development of effective treatments for multiple primary cancers is important.
Gastrointestinal Involvement of Testicular Germ Cell Tumor: A Case Report and Literature Review
Authors: Oluwaseun Shogbesan, Abdullateef Abdulkareem, Asad Jehangir, Sunila Byreddy, Sharon Swierczynski, Anthony Donato
Journal: Case Rep Gastrointest Med (2017)
MeSH terms: Case Reports

Testicular germ cell tumors (GCT) are the commonest solid tumors in young men. Typical presentation is with painless scrotal swelling; however, symptoms related to complications or metastasis may be the initial presentation. Gastrointestinal (GI) metastasis is seen in about 5% of patients with germ cell tumors and presentation is commonly with GI bleed. It is important to have GCT as a differential diagnosis of GI bleed in young men presenting with unexplained anemia as direct questioning about scrotal swelling and genital examination when appropriate will guide further investigation and facilitate prompt diagnosis. We present a case of a 26-year-old man with testicular germ cell tumor and severe anemia secondary to extension and perforation of duodenum by retroperitoneal metastasis and a review of the literature on the gastrointestinal manifestations of testicular germ cell tumors.
Case Report: Case Series of Children With Multisystem Inflammatory Syndrome Following SARS-CoV-2 Infection in Switzerland
Authors: Athina Fouriki, Yves Fougère, Caroline De Camaret, Géraldine Blanchard Rohner, Serge Grazioli, Noémie Wagner, Christa Relly, Jana Pachlopnik Schmid, Johannes Trück, Lisa Kottanatu, Estefania Perez, Marie-Helene Perez, Damien Schaffner, Sandra Andrea Asner, Michael Hofer
Journal: Front Pediatr (2021)
Keywords: anakinra, il-1ra, mis-c, sars-cov-2, child
MeSH terms: Case Reports

Since the beginning of the severe SARS-CoV-2 pandemic, an increasing number of countries reported cases of a systemic hyperinflammatory condition defined as multi-system inflammatory syndrome in children (MIS-C). The clinical features of MIS-C can be an overlap of Kawasaki Disease (KD), Toxic Shock Syndrome (TSS), Macrophage Activation Syndrome (MAS), or have often an acute abdominal presentation. Intravenous immunoglobulin (IVIG) is recommended as first line therapy in KD. Recent evidence suggests intravenous immunoglobulins (IVIG) resistance in some cases of SARS-CoV-2 related MIS-C, thereby questioning the benefit of immunomodulators such as IL-1 or IL-6 blocking agents. We report on a cohort of 6 Swiss children with SARS-CoV2 related MIS-C presenting with clinical features compatible with Incomplete KD and Toxic Shock Syndrome associated to a cytokine storm. Serum cytokine profile investigations showed increased IL1RA levels (8 to 22-fold) in 5 of the 6 patients (one patient had not been tested), whereas, IL-6 serum levels were increased only in the 3 patients of the 6 who were tested. With exception of one patient who had only benefited by Anakinra, all patients received at least one dose of IVIG. One patient has only received Anakinra with favorable evolution, and three patients had also a steroid treatment. In addition to all this anti-inflammatory medication two patients have also received one dose of anti-IL6. In conclusion, our case series reports on clinical and laboratory findings of most of Swiss cases with MIS-C and suggests the use of Anakinra as an alternative to steroids in these children, most of whom presented with high IL-1RA levels.
Recurrence and Familial Inheritance of Intronic NIPBL Pathogenic Variant Associated With Mild CdLS
Authors: Maura Masciadri, Anna Ficcadenti, Donatella Milani, Francesca Cogliati, Maria Teresa Divizia, Lidia Larizza, Silvia Russo
Journal: Front Neurol (2018)
Keywords: cornelia de lange, familial inheritance, intronic variant, mild phenotype, recurrent variant
MeSH terms: Case Reports

Splicing pathogenic variants account for a notable fraction of NIPBL alterations underlying Cornelia de Lange syndrome but are likely underrepresented, due to overlooking of non-canonical intronic variants by traditional and contemporary sequencing methods. We describe five subjects, belonging to three families, displaying a mild Cornelia de Lange syndrome phenotype who carry the NIPBL pathogenic variant c.5329-15A>G, affecting the IVS27 branch site, yet reported in a single case. By RNA analysis we evidenced two alternative transcripts: the exon 28 in frame skipped transcript, described in the published case and an out-of-frame transcript retaining 14 nucleotides of IVS27 3'end. Even if both aberrant transcripts are at negligible levels, their presence justifies the CdLS phenotype shared by our patients consisting of borderline-mild cognitive impairment and slight but typical facial dysmorphisms. Transmission of the pathogenic variant from pauci-symptomatic mother to her siblings emphasizes the need of molecular diagnosis extended to deep intronic regions in patients with subtle but recognizable CdLS phenotype.
Lifetime development of behavioural phenotype in the house mouse (Mus musculus)
Authors: Vera Brust, Philipp M Schindler, Lars Lewejohann
Journal: Front Zool (2015)
Keywords: adolescence, adulthood, behavioural phenotype, behavioural stability, life stages, ontogeny, phenotypic plasticity, post-reproductive age, postnatal, prenatal
MeSH terms: Review

With each trajectory taken during the ontogeny of an individual, the number of optional behavioural phenotypes that can be expressed across its life span is reduced. The initial range of phenotypic plasticity is largely determined by the genetic material/composition of the gametes whereas interacting with the given environment shapes individuals to adapt to/cope with specific demands. In mammalian species, the phenotype is shaped as the foetus grows, depending on the environment in the uterus, which in turn depends on the outer environment the mother experiences during pregnancy. After birth, a complex interaction between innate constitution and environmental conditions shapes individual lifetime trajectories, bringing about a wide range of diversity among individual subjects. In laboratory mice inbreeding has been systematically induced in order to reduce the genetic variability between experimental subjects. In addition, within most laboratories conducting behavioural phenotyping with mice, breeding and housing conditions are highly standardised. Despite such standardisation efforts a considerable amount of variability persists in the behaviour of mice. There is good evidence that phenotypic variation is not merely random but might involve individual specific behavioural patterns consistent over time. In order to understand the mechanisms and the possible adaptive value of the maintenance of individuality we review the emergence of behavioural phenotypes over the course of the life of (laboratory) mice. We present a literature review summarizing developmental stages of behavioural development of mice along with three illustrative case studies. We conclude that the accumulation of environmental differences and experiences lead to a "mouse individuality" that becomes increasingly stable over the lifetime.
De novo 2.3 Mb microdeletion of 1q32.2 involving the Van der Woude Syndrome locus
Authors: Ene-Choo Tan, Eileen Cp Lim, Seng-Teik Lee
Journal: Mol Cytogenet (2013)
Keywords: 1q32, irf6 gene, microdeletion, orofacial clefting, snp array, syndromic clefting, van der woude syndrome
MeSH terms: Case Reports

Background:
Van der Woude syndrome is the most common among syndromes which include cleft lip and/or cleft palate as one of the presentations. It is usually caused by mutations in the interferon regulatory factor 6 (IRF6) gene.
Case presentation:
We previously reported on a patient with suspected deletion of the IRF6 gene. Using the Affymetrix Human SNP 6.0 Array, the interstitial deletion has been confirmed and found to be approximately 2.327-2.334 Mb within the 1q32.2 region. Although several known genes were deleted, the patient has no other phenotype apart from the orofacial presentations typical of VWS. The same deletion was not present in either parent and his two siblings were also phenotypically normal.
Conclusions:
Other than IRF6, the genes which are deleted in this patient appear to be insensitive to copy number and haploinsufficiency. We compared the deletion in this patient with another case which was also mapped by high resolution array but had additional phenotypic features.
An unusual cause of a complete heart block in a young healthy man! (a case report)
Authors: Salma Charfeddine, Syrine Triki, Wiem Feki, Tarak Ellouze, Leila Abid, Rania Hammami, Samir Kammoun
Journal: Pan Afr Med J (2020)
Keywords: myocarditis, case report, heart-block, high degree atrioventricular block
MeSH terms: Heart Block / etiology, Myocarditis / complications, Syncope / etiology, Case Reports, Acute Disease, Adult, Electrocardiography, Heart Block / diagnosis, Heart Block / virology, Humans, Magnetic Resonance Imaging, Male, Myocarditis / diagnostic imaging, Myocarditis / virology

Acute myocarditis represents a challenging diagnosis as there is no pathognomonic clinical presentation. It is rare to see heart block as the first-and-only presentation of infectious myocarditis. We report the case of a young healthy patient who presented with syncope secondary to a complete heart block. It was caused by acute presumed viral myocarditis. The diagnosis was confirmed with cardiac magnetic resonance imaging. With close monitoring, the EKG abnormalities resolved over the following 5 days. In this case report, we present the importance of several imaging tools to diagnose a rare and reversible cause of conduction disturbances. In at-risk individuals, clinicians should rule out a treatable cause of heart block before proceeding with permanent pacemaker implantation due to enormous clinical and cost implications involved.
Jejunal perforation and upward migration of double J stents during the cystoscopic procedure: a case report and review of literature
Authors: Faisal Ahmed, Qasem Alyhari, Saif Ghabisha, Saleh Al-Wageeh, Ebrahim Al-Shami, Menawar Dajenah, Waleed Aljbri, Fawaz Mohammed
Journal: Pan Afr Med J (2022)
Keywords: double-j stent, case report, complications, jejunal perforation, upward migration
MeSH terms: Intestinal Perforation / etiology, Intestinal Perforation / surgery, Peritonitis / etiology, Peritonitis / surgery, Ureter / surgery, Case Reports, Review, Aged, Humans, Male, Stents, Ureteroscopy, Urinary Bladder

While double J (DJ) stenting is common worldwide in the urological procedure, it may associate with severe and catastrophic complications. Penetration of the jejunum and upward migration of double J (DJ) stents during cystoscopic DJ stent procedure are rare complications with few reported cases in the literature. We present a 65-year-old male presented with acute renal failure and peritonitis one week after failed cystoscopic removal of DJ stents. Radiographic investigations showed upward migration of the right DJ stent and a total displacement of the left DJ stent to the peritoneal cavity with peritonitis, bladder perforation, and jejunal injuries. The right DJ stent was removed via the ureteroscopic procedure. Then, open abdominal surgery was performed to remove the left DJ stent and repair the injured bladder wall and jejunal segment. In conclusion, synchronous upward DJ stent migration and peritoneal DJ stent malposition with jejunal and bladder injuries are rare and severe complications of the cystoscopic DJ stent procedure. The treatment should be performed depending on the time of diagnosis, nature of the injury, and general clinical conditions of the patient.
Deinagkistrodon acutus envenomation: a report of three cases
Authors: Chin-Lung Cheng, Yan-Chiao Mao, Po-Yu Liu, Liao-Chun Chiang, Shu-Chen Liao, Chen-Chang Yang
Journal: J Venom Anim Toxins Incl Trop Dis (2017)
Keywords: coagulopathy, deinagkistrodon acutus, envenomation, snakebite, thrombocytopenia
MeSH terms: Case Reports

Background:

Deinagkistrodon acutus envenomation is associated with severe hematological and wound complications but is rarely described.
Case presentation:
Herein, we report three cases of victims bitten by D. acutus and indicate that rapid-onset severe coagulopathy and thrombocytopenia are distinct features of D. acutus snakebite, which are not observed in other crotaline snakebites (i.e., Trimeresurus stejnegeri and Protobothrops mucrosquamatus) in Taiwan. The toxic effects could occur as early as 2 to 3 h following D. acutus envenomation and persist if the administration of specific antivenom is delayed or even not commenced. Based on our findings, 2 to 4 vials of specific antivenom as the first dose should be administered to victims and repeated at 6 to 8 h intervals if coagulopathy or thrombocytopenia persists. Fresh frozen plasma or platelet replacement is probably safe as an adjunct therapy for D. acutus bite in the presence of venom-induced consumptive coagulopathy.
Conclusion:
Severe coagulopathy and thrombocytopenia could occur as early as 2 to 3 h after D. acutus envenomation. The current recommendation for antivenom is 2 to 4 vials as the first dose and repeated every 6- to 8 h if coagulopathy or thrombocytopenia persists. These cases studied may be helpful to first-line medical personnel in the early diagnosis and management of D. acutus envenomation among other crotaline snakebites in Taiwan.