OpenMed/multicare-articles huggingface dataset:
A Fatal Case of Influenza B Myocarditis with Cardiac Tamponade
Authors: Dominick Roto, Michelle L Malnoske, Shira Winters, Steve N Georas
Journal: Case Rep Crit Care (2018)
MeSH terms: Case Reports

Background:
Influenza B is generally regarded as a less severe counterpart to influenza A, typically causing mild upper respiratory symptoms. Myocardial involvement with influenza B is a rare complication, better described in children than adults. However, when it occurs, it can lead to profound myocarditis with progression to shock requiring aggressive supportive care.
Case presentation:
We present a case of cardiac tamponade in the setting of influenza B infection in a previously healthy 57-year-old woman, with progression to refractory shock and death. Autopsy revealed myocardial necrosis with infiltration of CD3+ lymphocytes, and little evidence of viral pneumonia.
Conclusions:
Myocarditis is a rare complication of influenza B in adults, and subsequent pericardial effusion with tamponade physiology is a previously unreported event in an otherwise healthy adult without other medical comorbidities. While rare, this is a serious and potentially fatal complication that clinicians should be aware of when evaluating a patient with suspected viral illness who is exhibiting shock physiology.
The effect of recombinant granulocyte colony-stimulating factor on oral and periodontal manifestations in a patient with cyclic neutropenia: a case report
Authors: Sergio Matarasso, Vincenzo Daniele, Vincenzo Iorio Siciliano, Michele D Mignogna, Gianmaria Andreuccetti, Carlo Cafiero
Journal: Int J Dent (2009)
MeSH terms: Case Reports

Cyclic Neutropenia (CN) is characterized by recurrent infections, fever, oral ulcerations, and severe periodontitis as result of the reduced host defences. The previous studies have established the effectiveness of recombinant granulocyte colony-stimulating factor (GCSF) to increase the number and the function of neutrophils in the peripheral blood in this disease. In a 20-year-old Caucasian female with a diagnosis of cyclic neutropenia, oral clinical examination revealed multiple painful ulcerations of the oral mucosa, poor oral hygiene conditions, marginal gingivitis, and moderate periodontitis. The patient received a treatment with G-CSF (Pegfilgrastim, 6 mg/month) in order to improve her immunological status. Once a month nonsurgical periodontal treatment was carefully performed when absolute neutrophil count (ANC) was >/=500/muL. The treatment with G-CSF resulted in a rapid increase of circulating neutrophils that, despite its short duration, leaded to a reduction in infection related events and the resolution of the multiple oral ulcerations. The disappearance of oral pain allowed an efficacy nonsurgical treatment and a normal tooth brushing that determined a reduction of probing depth (PD </= 4 mm) and an improvement of the oral hygiene conditions recorded at 6-month follow-up.
Bilateral Bone Ridge Splitting in Maxilla with Immediate Implant Placement in a Patient with Osteoporosis: A Clinical Report with 2-Year Follow-up
Authors: Rafał Flieger
Journal: Case Rep Dent (2019)
MeSH terms: Case Reports

Every year, a higher percentage of bisphosphonates is prescribed for osteoporosis treatment which can lead to bone osteonecrosis after several surgical procedures in the oral cavity. This report describes an approach to restore two missing teeth, employing bilateral bone ridge splitting in the maxilla with immediate placement of implants in a patient using bisphosphonates in the management of osteoporosis. Two titanium implants with a width of 3.45 mm and a length of 10 mm were placed in the maxillary ridge with a diameter of 4.4 mm and 3.0 mm in positions 15 and 24 according to the classification of the World Dental Federation. The implants were placed immediately by bone splitting, using a piezosurgery device and guided bone regeneration with an alloplastic material and a collagen membrane. Five months later, the implants were uncovered and the final porcelain crowns were cemented. 24 months later, the control through clinical and radiographical examinations showed no bone loss in the collar part of the implants and the proper status of the peri-implant soft tissue without any signs of inflammation. Piezosurgery is a useful and safe method of ridge splitting in a very thin ridge (4.5 and 3.0 mm).
Seatbelt: a double-edged sword
Authors: P Raychaudhuri, N K Cheung, C Bendinelli, M Puvaneswary, R Ferch, Rajendra Kumar
Journal: Case Rep Pediatr (2012)
MeSH terms: Case Reports

Intra-abdominal vascular injury due to blunt trauma is unusual in children. Due to its rarity, detailed reports dealing with its management are scarce in paediatric literature. Diagnosis of these injuries is challenging, and a high degree of awareness is necessary for rapid identification and treatment of these injuries. We report the case of a child with seatbelt sign and mesenteric vein injury due to blunt trauma to the abdomen during a motor vehicle accident where the seatbelt was incorrectly placed. She also sustained cervical vertebral injury. The pattern of injuries in children in these situations may differ from that found in adults. While seatbelts have undoubtedly saved many lives, awareness about correct placement of these restraints is extremely necessary.
Adenosine kinase deficiency with neurodevelopemental delay and recurrent hepatic dysfunction: A case report
Authors: Marjan Shakiba, Fatemeh Mahjoub, Hassan Fazilaty, Fereshteh Rezagholizadeh, Arghavan Shakiba, Maryam Ziadlou, William A Gahl, Babak Behnam
Journal: Adv Rare Dis (2016)

Hypermethioninemia may be benign, present as a nonspecific sign of nongenetic conditions such as liver failure and prematurity, or a severe, progressive inborn error of metabolism. Genetic causes of hypermethioninemia include mitochondrial depletion syndromes caused by mutations in the MPV17 and DGUOK genes and deficiencies of cystathionine β-synthase, methionine adenosyltransferase types I and III, glycine N-methyltransferase, S-adenosylhomocysteine hydrolase, citrin, fumarylacetoacetate hydrolase, and adenosine kinase. Here we present a 3-year old girl with a history of poor feeding, irritability, respiratory infections, cholestasis, congenital heart disease, neurodevelopmental delay, hypotonia, sparse hair, facial dysmorphisms, liver dysfunction, severe hypermethioninemia and mild homocystinemia. Genetic analysis of the adenosine kinase (ADK) gene revealed a previously unreported variant (c.479-480 GA>TG) resulting in a stop codon (p.E160X) in ADK. A methionine-restricted diet normalized the liver function test results and improved her hypotonia.
Traumatic implantation: a novel aetiology in the development of peritoneal mesothelioma
Authors: Nicola Humphrys, Amy Downing, Luke Evans, Martin Sinclair
Journal: Case Rep Emerg Med (2013)

Peritoneal mesothelioma is a rare intra-abdominal malignancy. Its aetiology has been thought to be due to either inhalation or ingestion of asbestos particles. We present a case of peritoneal mesothelioma developing as a result of a novel third route and the inoculation of fibres into the peritoneal cavity by penetrating trauma and direct transport. This case report highlights the important long term consequences of penetrating abdominal trauma and the need for vigilance in undertaking peritoneal toilet.
An Unusual Visit from an Old Foe: Oral Presentation of Syphilis in a Teenage Patient
Authors: Bedirhan Tarhan, Sydur Rahman, Diana Halloran, Jeremy Sites, Avni Bhatt, Kathleen Ryan, Maritza Plaza-Verduin, Thao Vu
Journal: Case Rep Pediatr (2021)
MeSH terms: Case Reports

The authors report an atypical case of secondary syphilis in an adolescent female presenting to a tertiary-care center with fever, weight loss, oral sores, painful inguinal lymphadenopathy, and transient macular rash. Given the lower prevalence of syphilis in adolescent females, this infection was not included on the initial differential diagnosis. The evolving presentation of syphilis over time complicates the diagnosis and management of these infections, as it did for the patient in this report. The authors provide a detailed discussion of the patient's clinical findings, including the protean features of syphilis infection. This case is particularly relevant to the fields of general pediatrics and pediatric hospital medicine.
Fat Embolism and Nonconvulsive Status Epilepticus
Authors: Yanetsy Olivera Arencibia, Mai Vo, Jennifer Kinaga, Jorge Uribe, Gloria Velasquez, Mario Madruga, S J Carlan
Journal: Case Rep Neurol Med (2018)
MeSH terms: Case Reports

Fat embolism syndrome (FES) typically occurs following orthopedic trauma and may present with altered mental status and even coma. Nonconvulsive status epilepticus is an electroclinical state associated with an altered level of consciousness but lacking convulsive motor activity and has been reported in fat embolism. The diagnosis is clinical and is treated with supportive care, antiepileptic therapy, and sedation. A 56-year-old male presented with altered mental status following internal fixation for an acute right femur fracture due to a motor vehicle accident 24 hours earlier. Continued neuromonitoring revealed nonconvulsive status epilepticus. Magnetic resonance imaging of the brain showed multiple bilateral acute cerebral infarcts with a specific pattern favoring the diagnosis of fat embolism syndrome. He was found to have a significant right to left intracardiac shunt on a transesophageal echocardiogram. He improved substantially over time with supportive therapy, was successfully extubated on day 6, and discharged to inpatient rehabilitation on postoperative day 15. Fat embolisms can result in a wide range of neurologic manifestations. Nonrefractory nonconvulsive status epilepticus that responds to antiepileptic drugs, sedation, and supportive therapy can have a favorable outcome. A high index of suspicion and early recognition reduces the chances of unnecessary interventions and may improve survival.
Clinical Heinz Body Anemia in a Cat After Repeat Propofol Administration Case Report
Authors: Courtney L Baetge, Lauren C Smith, Carolina P Azevedo
Journal: Front Vet Sci (2020)
Keywords: heinz body, anemia, anesthesia, case report, feline, propofol, repeated
MeSH terms: Case Reports

Heinz body formation has been reported in cats repeatedly administered propofol for anesthesia induction, although the resultant changes were deemed of little clinical significance (1, 2). This report suggests repeated propofol administration to some individual cats might induce anemia with clinical signs and cessation of propofol administration may result in rapid resolution. A 9-years-old American Domestic Shorthair cat receiving a 20-fraction radiation protocol for lateral thoracic fibrosarcoma showed lethargy, decreased appetite and activity, and Heinz body (3+ on blood smear examination) anemia (packed cell volume 22%; reference interval 24-45%) after 12 repeated propofol anesthesia inductions. The anesthesia induction protocol was adjusted to exclude propofol. Over the following week, the anemia resolved (packed cell volume, 30%), and the cat's activity level, appetite and attitude improved. The total dose of propofol received over the 12 treatments was 62.4 mg/kg.
Ultrasound Guided Continuous Sciatic Nerve Block for Acute Herpetic Neuralgia
Authors: Thierry C Bagaphou, Domenico Santonastaso, Eleonora Gargaglia, Lucia Norgiolini, Cinzia Tiburzi, Stefano Cristallini, Vittorio Cerotto, Fabio Gori
Journal: Case Rep Anesthesiol (2019)
MeSH terms: Case Reports

Herpes Zoster (HZ) is the reactivation of a well-known viral disease which manifests itself with painful skin lesions. An effective analgesic method during the acute phase of HZ can contribute to decrease the incidence of postherpetic neuralgia (PHN) by reducing neural sensitization. Sciatic nerve block (SNB) is useful in the management of distal lower extremity pain sustained by the sciatic nerve. We describe our experience with a continuous ultrasound guided subgluteus sciatic nerve block in a patient with herpetic neuralgia- (HN-) related refractory acute left leg pain.
Regenerative Endodontic Treatment of Maxillary Incisors with a History of Severe Traumatic Injury
Authors: Nazanin Chitsaz, Mehrfam Khoshkhounejad, Hadi Assadian, Behnam Bolhari, Mohammadreza Sharifian, Zahra Mohammadi
Journal: Case Rep Dent (2021)
MeSH terms: Case Reports

The treatment objective for children with avulsed anterior teeth should concentrate on preserving the alveolar bone volume and contour. Posttraumatic external inflammatory root resorption (EIRR) is also a high-risk complication often observed in children. Regenerative endodontic procedure (REP) has been considered a successful treatment to arrest EIRR, especially in posttraumatic cases. This case report presents clinical outcomes of REP in two teeth of an 8-year-old systemically healthy patient with a history of severe dentoalveolar traumatic injury, one with a history of avulsion, and the other with an EIRR. The treatment consisted of REP on both teeth #8 and #9. The results showed some evidence of maturation in the apical third of tooth #9 and resolution of signs and symptoms on tooth #8.
The Challenges of Apnea Tests in the Determination of Brain Death in Child Patient on Extracorporeal Membrane Oxygenation
Authors: Lingling Xu, Yujian Liang, Yuan Liao, Jian Rong, Guixing Xu, Wen Tang
Journal: Front Pediatr (2020)
Keywords: ecmo, apnea test, brain death, child, donation
MeSH terms: Case Reports

Extracorporeal membrane oxygenation (ECMO) is a life-support modality used in patients with refractory cardiac and/or respiratory failure. ECMO is linked with high risk of neurological complications including brain death. Neurological monitoring during ECMO is important for identifying patients who are suspected of brain death and allows to discontinue ineffective medical treatments. Brain death (BD) is an irreversible cessation of functions of the entire brain, containing the brainstem. The apnea test (AT) is an essential part in the clinical determination of brain death. An apnea test is by neurologic criteria compulsory to confirm BD in China. Apnea test remains a problem for patients receiving ECMO. Currently, there are not any consensus guidelines for the safe performance of AT during ECMO. We report the case of a child on venous-arterial ECMO post-cardiac arrest in whom we performed an apnea test to determine death by neurologic criteria. Decreasing sweep gas flow rate 0.05 L/min every 5 min led to a PaCO2 increase of more than 20 mmHg of apnea. The results of the AT was positive. When he was determined brain dead, his parents decided to donate his organs. AT can be performed on potential donor children on ECMO by decreasing the sweep gas flow. It is a safe and effective method and is important for BD determination.
Laparoscopic Finding of Ectopic Adrenocortical Tissue in a 2-Year-Old Boy with Vanishing Testis
Authors: Antonio Marte
Journal: European J Pediatr Surg Rep (2018)
Keywords: ectopic adrenocortical tissue, laparoscopy, vanishing testis
MeSH terms: Case Reports

Ectopic adrenocortical tissue (EAT) along the spermatic cord is an unusual condition in children. The author reports on a 2-year-old boy with impalpable testis. On laparoscopy, EAT was detected along the hypotrophic spermatic vessels and excised. These remnants should be removed to prevent hormone production or malignant transformation.
A rare case of urinary tract infection due to Trichosporon asahii in a diabetic patient
Authors: Maryem Iken, Ahmed Belkouch, Badia Bellarj, Hafida Naoui, Laila Boumhil, Anass El Bouti, Said Jidane, Lahcen Belyamani, Badreddine Lmimouni
Journal: Pan Afr Med J (2015)
Keywords: trichosporon asahii, amphotericin b, urinary tract infection
MeSH terms: Diabetes Mellitus, Type 1 / complications, Opportunistic Infections / microbiology, Trichosporon / isolation & purification, Trichosporonosis / microbiology, Urinary Tract Infections / microbiology, Case Reports, Acute Kidney Injury / etiology, Amphotericin B / therapeutic use, Antifungal Agents / therapeutic use, Diabetes Mellitus, Type 1 / immunology, Humans, Immunocompromised Host, Male, Middle Aged, Opportunistic Infections / diagnosis, Opportunistic Infections / drug therapy, Trichosporon / classification, Trichosporon / pathogenicity, Trichosporonosis / diagnosis, Trichosporonosis / drug therapy, Urinary Tract Infections / drug therapy, Urine / microbiology, Virulence, Antifungal Agents, Amphotericin B

Trichosporon asahii is a basidiomycete yeast responsible for white piedra and onychomycosis in the immunocompetent host. In the immunocompromised patients, invasive infections are reported; their diagnosis is difficult and they are associated with high mortality rate. Urinary infection due to Trichosporon Asahi is rare but its incidence increasing. We report the case of a 58 year old diabetic patient. The yeast was isolated from urine samples of three consecutive crops in pure form. The patient improved after antifungal therapy.
Dandy-Walker malformation: An incidental finding
Authors: Jyothi Tadakamadla, Santhosh Kumar, G P Mamatha
Journal: Indian J Hum Genet (2010)
Keywords: dandy–walker, high arch palate, hypertelorism
MeSH terms: Case Reports

Dandy-Walker malformation (DWM) is a rare intracranial congenital abnormality that affects the cerebellum and some of its components; particularly cerebellar vermis, fourth ventricle and is characterized by an enlarged posterior fossa. Although there is an extensive list of signs attributed to DWM, final diagnosis is solely dependent on imaging techniques as there are no signs that are characteristic of DWM. This article reports a case with DWM who was diagnosed by magnetic resonance imaging.
Diagnostic traction and dorsal locking plate stabilization of a fifth and sixth thoracic vertebral fracture/luxation in a golden retriever: Case report
Authors: William J Tammaro, Peter J Early, Robert Bergman, Brian L Petrovsky, Karl H Kraus
Journal: Front Vet Sci (2022)
Keywords: case report, diagnostic traction, dorsal locking plates, spinal stabilization, thoracic vertebral fracture/luxation
MeSH terms: Case Reports

Traction was used to diagnose instability of a T5-T6 traumatic luxation that was stabilized with locking plates in the laminae and dorsal pedicles. A two-year-old, 27 kg, female spayed golden retriever was presented to a veterinary teaching hospital after being referred for possible mandibular and spinal fractures after being hit by a car. The dog presented non-ambulatory paraparetic with intact pain perception. Computed tomographic (CT) imaging showed a fifth and sixth thoracic vertebral fracture/luxation, with and without manual traction. Surgical stabilization of the spine was performed with bilateral dorsally placed locking plates (String-of-Pearls, Orthomed, UK) in the laminae and dorsal aspects of the vertebral pedicles. The dog recovered well, and neurologic status improved significantly overnight and continued to improve up until discharge, which was 6 days postoperatively. Upon recheck exam at 8 weeks postoperatively, the dog appeared neurologically normal with no obvious surgical complications. This case demonstrates that diagnostic traction-the process of pulling, during imaging, on the dog's pelvis while the forelimbs are secured in extension-demonstrated instability of the spine which was not readily apparent on initial CT imaging. Additionally, the dorsal locking plate stabilization is a viable fixation option that provided acceptable stabilization of the mid-thoracic vertebrae.
A Rare Case of Bradycardia and Hypotension Following Administration of Ondansetron to a Patient During Spinal Fixation Surgery
Authors: Sandeep Dey, Stuti Bhamri, Manish Arora, Mukesh Gupta
Journal: Cureus (2023)
Keywords: bradycardia, hypotension, lumbar spine surgery, ondansetron, prone position surgery
MeSH terms: Case Reports

Ondansetron is commonly used during the peri-operative period for the prophylaxis of postoperative nausea and vomiting (PONV). It is a 5-hydroxytryptamine 3 (5-HT3) receptor antagonist. Although relatively safe, few cases of ondansetron-induced bradycardia are described in the literature. Here, we present the case of a 41-year-old female with a burst fracture of the lumbar (L2) vertebrae following a fall from height. The patient underwent spinal fixation in the prone position. The intra-operative period was otherwise uneventful, except for an unprecedented incidence of bradycardia and hypotension following administration of intravenous (IV) ondansetron, at the time of closure of the surgical wound site. It was managed with IV atropine and fluid bolus. The patient was shifted to a intensive care unit (ICU) postoperatively. The postoperative period was uneventful, and the patient was discharged in good health on postoperative day three.
RUNX1-PDCD6 fusion resulting from a novel t(5;21)(p15;q22) chromosome translocation in myelodysplastic syndrome secondary to chronic lymphocytic leukemia
Authors: Ioannis Panagopoulos, Ludmila Gorunova, Eva-Marie Jacobsen, Kristin Andersen, Francesca Micci, Sverre Heim
Journal: PLoS One (2018)
MeSH terms: Apoptosis Regulatory Proteins / genetics, Calcium-Binding Proteins / genetics, Core Binding Factor Alpha 2 Subunit / genetics, Leukemia, Lymphocytic, Chronic, B-Cell / genetics, Leukemia, Lymphocytic, Chronic, B-Cell / pathology, Myelodysplastic Syndromes / etiology, Oncogene Proteins, Fusion / genetics, Translocation, Genetic, Case Reports, Research Support, Non-U.S. Gov't, Amino Acid Sequence, Chromosome Banding, Chromosomes, Human, Pair 21, Chromosomes, Human, Pair 5, Female, Humans, In Situ Hybridization, Fluorescence, Middle Aged, Myelodysplastic Syndromes / diagnosis, Sequence Analysis, DNA, Apoptosis Regulatory Proteins, Calcium-Binding Proteins, Core Binding Factor Alpha 2 Subunit, Oncogene Proteins, Fusion, PDCD6 protein, human, RUNX1 protein, human

Leukemic cells often carry chromosome aberrations which generate chimeric genes of pathogenetic, diagnostic, and prognostic importance. New rearrangements giving rise to novel fusion genes define hitherto unrecognized genetic leukemia subgroups. G-banding, fluorescence in situ hybridization (FISH), and molecular genetic analyses were done on bone marrow cells from a patient with chronic lymphocytic leukemia (CLL) and secondary myelodysplasia. The G-banding analysis revealed the karyotype 46,XX,del(21)(q22)[9]/46,XX[2]. FISH on metaphase spreads with a RUNX1 break apart probe demonstrated that part of RUNX1 (from 21q22) had moved to chromosome band 5p15. RNA sequencing showed in-frame fusion of RUNX1 with PDCD6 (from 5p15), something that was verified by RT-PCR together with Sanger sequencing. Further FISH analyses with PDCD6 and RUNX1 home-made break apart/double fusion probes showed a red signal (PDCD6) on chromosome 5, a green signal on chromosome 21 (RUNX1), and two yellow fusion signals, one on der(5) and the other on der(21). Reassessment of the G-banding preparations in light of the FISH and RNA-sequencing data thus yielded the karyotype 46,XX,t(5;21)(p15;q22)[9]/46,XX[2]. The t(5;21)(p15;q22)/RUNX1-PDCD6 was detected only by performing molecular studies of the leukemic cells, but should be sought after also in other leukemic/myelodysplastic cases with del(21q).