OpenMed/multicare-articles huggingface dataset:
Radiation Treatment for Inoperable Local Relapse of Parathyroid Carcinoma With Symptomatic Hypercalcemia: A Case Report
Authors: Heleen Bollen, Brigitte Decallonne, Sandra Nuyts
Journal: Front Oncol (2021)
Keywords: case report, hypercalcemia, parathyroid carcinoma, radiosensitivity, radiotherapy, symptomatic treatment
MeSH terms: Case Reports

Background:
Parathyroid carcinoma (PC) is an extremely rare malignancy, characterized by slow progression, frequent recurrences and difficult-to-control hypercalcemia which is typically the main contributor to the morbidity and mortality of these patients. Patients often undergo repeated surgical resections, whether or not in combination with adjuvant radiation treatment. The role of radiation therapy within the symptomatic treatment of PC currently remains unclear.
Case description:
We describe a 30-year-old male patient with an inoperable local relapse of PC and secondary symptomatic hypercalcemia, maximally pharmacologically treated. After a local radiation treatment to a total dose of 70 Gray in 35 fractions serum calcium and parathyroid hormone (PTH) levels decreased, accompanied by improvement of the severe gastro-intestinal disturbances.
Conclusion:
For patients with inoperable symptomatic PC despite maximal medical treatment who are in a good overall condition, radiation treatment can be considered in well-defined cases to decrease symptoms and improve quality of life.
Unilateral Intraparotid Swelling: A Case Report of Kimura's Disease and Review of Differential Diagnosis
Authors: N W Savage, V Vucicevic Boras
Journal: Case Rep Otolaryngol (2013)

An interesting case of Kimura's disease was described in the 42-year-old patient manifesting itself as a unilateral parotid swelling, albeit the disease usually affects both parotid glands. Furthermore, first pathohistological finding was not suggestive of the disease, revealing only fatty tissue, but on the repeated biopsy together with CT the correct diagnosis was established. It should be emphasized that Kimura's disease has to be taken into account while making differential diagnosis in parotid gland swellings, especially in people of Oriental origin.
Application of a chairside anaerobic culture test for endodontic treatment
Authors: Masahiro Yoneda, Seidai Kita, Nao Suzuki, Sonia M Macedo, Kosaku Iha, Takao Hirofuji
Journal: Int J Dent (2010)
MeSH terms: Case Reports

Periapical lesions are caused by bacterial infections. The fundamental objective of endodontic treatment is to eliminate bacteria present in the root canal system because they play an important role in the development and maintenance of periapical lesions. Therefore, confirming the absence of bacteria before filling root canals is important. Anaerobic culture tests have been used in many endodontic cases, and they have brought about good treatment outcomes. These tests, however, require specific apparatuses and bacteriological techniques. Here, we report a chairside anaerobic culture test that does not require any specialized apparatuses or techniques. We also report two endodontic cases in which this simple test was used. Both patients were diagnosed with chronic purulent periapical lesions. After confirming the absence of bacteria in the root canals, they were filled with gutta-percha points. At followup, the radiolucencies showed recovery, although longterm observation is under way. From these results, the authors conclude that this simple chairside anaerobic culture test is effective for evaluating periapical lesion treatment procedures.
Case report: Use of 68Ga-DOTATATE-PET for treatment guidance in complex meningioma disease
Authors: Anna-Katharina Meißner, Niklas von Spreckelsen, Abdulkader Al Shughri, Anna Brunn, Gina Fuertjes, Marc Schlamann, Matthias Schmidt, Markus Dietlein, Daniel Rueß, Maximilian I Ruge, Norbert Galldiks, Roland Goldbrunner
Journal: Front Oncol (2022)
Keywords: 68 ga-dotatate-pet, sstr2 expression, atypical meningioma, case report, complex meningioma disease
MeSH terms: Case Reports

Currently, contrast-enhanced MRI is the method of choice for treatment planning and follow-up in patients with meningioma. However, positron emission tomography (PET) imaging of somatostatin receptor subtype 2 (SSTR2) expression using 68Ga-DOTATATE may provide a higher sensitivity for meningioma detection, especially in cases with complex anatomy or in the recurrent setting. Here, we report on a patient with a multilocal recurrent atypical meningioma, in which 68Ga-DOTATATE PET was considerably helpful for treatment guidance and decision-making.
Case Report: Glaucoma in an Infant With Retinopathy of Prematurity
Authors: Tamara Lee Lenis, Nahomy Ledesma Vicioso, Varun Reddy, Kyle D Kovacs, Sarah H Van Tassel, Anton Orlin
Journal: Front Pediatr (2021)
Keywords: anti-vegf (vascular endothelial growth factor), case report, glaucoma, laser retinal photocoagulation, myopia, retinopathy of prematurity (rop)
MeSH terms: Case Reports

Retinopathy of prematurity (ROP) is a leading cause of childhood blindness that occurs due to incomplete development of retinal blood vessels in preterm infants. Glaucoma is an ocular comorbidity in some patients with ROP, and it may be associated with immature anterior chamber development, ROP itself, or the treatment for ROP. There have been a few reports of narrow-angle glaucoma after laser treatment for ROP. In this case report, we describe the course of a female infant born at 24 weeks and 5 days of gestational age with treatment-requiring ROP treated with laser photocoagulation who subsequently developed very elevated intraocular pressure and shallow anterior chambers without pupillary block. The patient required bilateral ab externo trabeculotomy for elevated intraocular pressure, which normalized after the procedure. The patient has remained stable at the last follow-up at 51 weeks postmenstrual age. Differing from previous glaucoma presentations in this setting, we illustrate a case of elevated intraocular pressure and anterior chamber narrowing after laser therapy without pupillary block or synechiae. The possible multifactorial etiology of glaucoma in this patient, including incomplete angle development, ischemia, and laser treatment, highlight the need for glaucoma screening in patients with ROP, both in the short and long term.
Platelet-rich plasma for the treatment of lichen sclerosus
Authors: Beija K Villalpando, Saranya P Wyles, Lauren A Schaefer, Katherine J Bodiford, Alison J Bruce
Journal: Plast Aesthet Res (2021)
Keywords: platelet rich plasma, lichen sclerosus, penile lichen sclerosus, vulvar lichen sclerosus

Aim:
Evaluate the clinical effectiveness of platelet-rich plasma as a treatment for lichen sclerosus.
Methods:
A systematic review was performed. The electronic databases PubMed, Ovid MEDLINE®, Web of Science, Cochrane, clinicaltrials.gov were used to identify case studies, case series, prospective uncontrolled, and randomized controlled studies published between 1946 and April 21, 2021. Six prospective uncontrolled studies, one randomized double-blind prospective study, and one case report were included.
Results:
Platelet-rich plasma treatment was subjectively reported to improve quality of life, but objective measures demonstrating treatment efficacy were not observed. In addition, platelet-rich plasma preparation and administration between studies lacked standardization.
Conclusion:
Platelet-rich plasma may be used for symptomatic adjuvant treatment of lichen sclerosus, though additional double-blind controlled studies with standardized platelet-rich plasma protocols are needed to better characterize the efficacy of platelet-rich plasma.
Eight-Year Follow-Up Using a Fresh Osteochondral Allograft for a Femoral Head Chondroblastoma in a 17-Year-Old Patient
Authors: Louis-Charles Moreau, Philippe Beauchamp-Chalifour, Etienne L Belzile, Norbert Dion
Journal: Case Rep Orthop (2019)
MeSH terms: Case Reports

Chondroblastoma is a rare benign tumor that affects the epiphysis of long bones in adolescents. Chondroblastoma located in the femoral head is associated with a higher recurrence rate and carries the additional risks of head collapse and degenerative hip disease. Aggressive curettage followed by bone grafting is the current mainstay of treatment. To our knowledge, the long-term postoperative outcome of this technique remains unknown due to the short follow-up of previous case reports. We present the case of a 17-year-old male who underwent fresh osteochondral allograft following curettage of a femoral head chondroblastoma, using a Ganz surgical hip dislocation. He made an uneventful recovery without tumor recurrence. The patient was followed up to 8 years postoperatively. However, there were clinical and radiographic degenerative changes at 6 years of follow-up.
Topiramate-associated acute glaucoma in a migraine patient receiving concomitant citalopram therapy: a case-report
Authors: Luca Spaccapelo, Silvia Leschiutta, Claudio Aurea, Anna Ferrari
Journal: Cases J (2009)

We describe the case of a 34 year-old man with diagnosis of migraine with and without aura that developed myopia and acute glaucoma after 7 days of treatment with topiramate. The patient had also been taking citalopram daily for two months. Both topiramate and citalopram have been related to the increase of intraocular pressure and the development of glaucoma. We can't exclude that in this patient citalopram caused an increase of the ocular pressure in dose-dependent manner, facilitating topiramate-induced glaucoma. We recommend to pay particular attention in prescribing of topiramate in migraine patients who are already under treatment with citalopram or other antidepressants with a similar mechanisms of action.
A New MAMLD1 Variant in an Infant With Microphallus and Hypospadias With Hormonal Pattern Suggesting Partial Hypogonadotropic Hypogonadism-Case Report
Authors: Diego Yeste, Cristina Aguilar-Riera, Gennaro Canestrino, Paula Fernández-Alvarez, María Clemente, Núria Camats-Tarruella
Journal: Front Endocrinol (Lausanne) (2022)
Keywords: mamld1 gene, different sex development (dsd), hypogonadotropic hypogonadism, hypospadias, microphallus, minipuberty
MeSH terms: Hypogonadism / genetics, Hypospadias / genetics, Case Reports, DNA-Binding Proteins / genetics, Dihydrotestosterone, Humans, Luteinizing Hormone, Male, Nuclear Proteins / genetics, Testis / metabolism, Testosterone, Transcription Factors / genetics, Transcription Factors / metabolism, DNA-Binding Proteins, MAMLD1 protein, human, Nuclear Proteins, Transcription Factors, Dihydrotestosterone, Testosterone, Luteinizing Hormone

MAMLD1 (X chromosome) is one of the recognized genes related to different sex development. It is expressed in testis and ovaries and seems to be involved in fetal sex development and in adult reproductive function, including testosterone biosynthesis. However, its exact role remains unclear. Over 40 genetic variants have been described, mainly in male individuals and mostly associated with hypospadias. Although MAMLD1 has been shown to regulate the expression of the steroidogenic pathway, patients with MAMLD1 variants mostly show normal gonadal function and normal testosterone levels. Here we describe a patient (46,XY) with hypospadias and microphallus, with low testosterone and dihydrotestosterone (DHT) levels, and with inappropriately low values of luteinizing hormone (LH) during minipuberty. This hormonal pattern was suggestive of partial hypogonadotropic hypogonadism. A stimulation test with hCG (4 months) showed no significant increase in both testosterone and dihydrotestosterone concentrations. At 5 months of age, he was treated with intramuscular testosterone, and the penis length increased to 3.5 cm. The treatment was stopped at 6 months of age. Our gonadal function massive-sequencing panel detected a previously unreported nonsense variant in the MAMLD1 gene (c.1738C>T:p.Gln580Ter), which was classified as pathogenic. This MAMLD1 variant, predicting a truncated protein, could explain his genital phenotype. His hormonal profile (low testosterone, dihydrotestosterone, and LH concentrations) together with no significant increase of testosterone and DHT plasma concentrations (hCG test) highlight the potential role of this gene in the biosynthesis of testosterone during the fetal stage and minipuberty of the infant. Besides this, the LH values may suggest an involvement of MAMLD1 in the LH axis or a possible oligogenesis. It is the first time that a decrease in DHT has been described in a patient with an abnormal MAMLD1.
Case report: Xenotransfusion of canine lyophilized platelets for hemostasis in a feline patient with post-operative abdominal hemorrhage
Authors: Elizabeth Mannucci, April Blong, Chelsea Zorn, Rebecca Walton
Journal: Front Vet Sci (2023)
Keywords: hemorrhage, platelets, thrombocytopenia, transfusions, xenotransfusion
MeSH terms: Case Reports

Objective:
To describe the management of post-operative abdominal hemorrhage with a xenotransfusion of canine lyophilized platelets in a feline patient.
Case summary:
A 9-year-old male castrated domestic shorthair presented for a spontaneous hemoabdomen secondary to hepatic amyloidosis. Clinically significant hemorrhage occurred in the perioperative and post-operative period and the patient received a massive transfusion and anti-fibrinolytic therapy in combination with a xenotransfusion of canine lyophilized platelets at 0.9 × 109 particles/kg and recombinant human factor VIIa (rhFVIIa). The combination of these interventions decreased transfusion requirements in this patient and the xenotransfusion was well tolerated with no acute or immediate transfusion reactions noted.
New or unique information provided:
This case report describes the xenotransfusion of canine lyophilized platelets in a feline patient with severe, non-compressible abdominal hemorrhage.
An Unusual Complication of Congenital Diaphragmatic Hernia
Authors: E Tian Tan, Keren Sloan, Kokila Lakhoo
Journal: European J Pediatr Surg Rep (2017)
Keywords: complications, congenital diaphragmatic hernia, gastrointestinal, neonatal, obstruction, surgery
MeSH terms: Case Reports

A term newborn was referred to our unit with a postnatal diagnosis of a right-sided congenital diaphragmatic hernia (CDH). She was managed with high-frequency oscillatory ventilation, inotropic support, and nitric oxide, with planned surgical repair when she was medically optimized. On day 6 of life, there was an acute deterioration causing difficulty maintaining adequate ventilation and the infant requiring increasing analgesia and paralysis, especially during abdominal examination. A repeat X-ray showed distended bowel loops in the right hemithorax when compared with previous films raising suspicion of bowel obstruction. The infant proceeded to emergency laparotomy in the neonatal intensive care unit. She was found to have a right-sided Bochdalek (posterolateral) defect. The entire small bowel was within the thoracic cavity and appeared dusky secondary to obstruction caused by compression of a herniated right liver lobe against the hernia defect. Bowel perfusion improved after reduction and a BioDesign patch was used to repair the defect. The infant went on to have a straightforward recovery and was transferred to her local hospital for ongoing care on day 17. Bowel obstruction is an uncommon complication in the perinatal period in infants with CDH. A high index of suspicion for bowel compromise is needed in neonates who deteriorate acutely after a period of stabilization. Imaging should be obtained as soon as possible and early surgical intervention may be life-saving.
Catheter-Related Acremonium kiliense Fungemia in a Patient with Ulcerative Colitis under Treatment with Infliximab
Authors: Fernando A Díaz-Couselo, Marcelo Zylberman
Journal: Case Rep Infect Dis (2011)
MeSH terms: Case Reports

Acremonium spp. are filamentous, cosmopolitan fungi commonly isolated from plant debris and soil. They are infrequent pathogens in humans. Acremonium fungemia has been reported in neutropenic patients associated with central venous catheters and in nonneutropenic patients receiving long-term total parenteral nutrition. TNF-α blockade is associated with fungal infections, but no Acremonium spp. infection had been reported up to the present. In this paper, we present a patient with ulcerative colitis who developed Acremonium kiliense fungemia associated with infliximab therapy while receiving total parenteral nutrition. The patient was successfully treated with voriconazole. Acremonium sp. infection must be suspected as another cause of fungal infection in patients under treatment with infliximab.
The Dark Pituitary: Hemochromatosis as a Lesser-Known Cause of Pituitary Dysfunction
Authors: Bert Verberckmoes, Sven Dekeyzer, Karen Decaestecker
Journal: J Belg Soc Radiol (2022)
Keywords: hemochromatosis, hypogonadotropic hypogonadism, iron deposition, magnetic resonance imaging, pituitary
MeSH terms: Case Reports

Teaching Point: Iron deposition in the pituitary gland in patients with primary and secondary hemochromatosis is a lesser-known cause of pituitary dysfunction and results in T2- and T2*-signal loss on MRI, other brain structures, in which iron deposition can be seen, are the choroid plexus and sporadically the circumventricular organs (e.g., the pineal gland).
Ketogenic Weight Loss Diet Rapidly Unmasks an Insulinoma
Authors: Erin Meier, Lydia Winnicka, Michael Lau, Duc Vo, Alla Joutovsky, Mangalore Amith Shenoy
Journal: Case Rep Endocrinol (2019)
MeSH terms: Case Reports

The ketogenic diet, a diet high in fat and extremely low in carbohydrates, has recently gained momentum and is increasingly employed by patients in order to lose weight. We report a case of an otherwise healthy 47-year-old male who developed seizures and hypoglycemia shortly after initiating this diet. Biochemical testing confirmed hyperinsulinemic hypoglycemia and a subsequent abdomen MRI showed a pancreatic mass. The tumor was ultimately excised with pathology confirming an insulinoma. It was felt that his abrupt decrease in carbohydrate consumption led to the rapid unmasking of this tumor.
Amputation Following Hand Escharotomy in Patients with Burn Injury
Authors: Scott M Schulze, Dexter Weeks, Joshua Choo, Damon Cooney, Alyssa L Moore, Matt Sebens, Michael W Neumeister, Bradon J Wilhelmi
Journal: Eplasty (2016)
Keywords: amputation burn patient, burn patient escharotomy, hand burn, hand burn amputation, hand escharotomy

Objective:
Hand burns are commonly seen in patients with burn injury. In the past, focus was on lifesaving measures, but with advances in burn care during the last century, the paradigm shifted to digital salvage and eventually to functional digital salvage. Good outcomes are heavily dependent on the care that is rendered during the initial management of the burn.
Methods:
A retrospective medical record review was conducted through the Central Illinois Regional Burn Center Patient Registry. Patients with burn injury treated with upper extremity and hand escharotomy between January 1, 2000, and December 31, 2005, were included in the study.
Results:
We identified a total of 34 patients with 57 burned hands. Six hands required delayed amputation of digits despite recognition of neurovascular compromise and escharotomy, yielding a 10% amputation rate. No correlation could be drawn with regard to total body surface area, age, or sex.
Conclusion:
Important principles in the acute phase include early splinting, recognition of the need for escharotomy and complete escharotomy when necessary, early excision and grafting, and involvement of occupational therapy for splinting and to guide both active and passive exercises. Although uncommon, some extremity burns may require subsequent amputation despite prompt attention and optimal treatment. In our case series, the need for amputation after successful escharotomies of salvageable digits was associated with full-thickness and electrical burns.
Endourologic Management of a 15-Year-Old Neglected, Fragmented, and Encrusted Ureteral Stent
Authors: Sarwar Noori Mahmood, Hewa Mahmoud Toffeq, Muhamed Hussen, Aram Karim, Choman Jamal, Aree Ali Said, Bryar Othman Aziz
Journal: J Endourol Case Rep (2018)
Keywords: double-j stents, broken, encrustations, forgotten
MeSH terms: Case Reports

Background: Ureteral stents (Double-J stents) have been widely used in urology to prevent or relieve ureteral obstruction and have become an integral part of urologic practice. However, if ureteral stents are kept for a prolonged period or neglected, they can cause significant morbidity because of complications such as stent migration, encrustation, occlusion, stone formation, and fragmentation. Therefore, it is crucial to remove stents as soon as possible after they have served their purpose, to prevent complications and morbidity. Case Presentation: In this study, we present a case of a 28-year-old man who presented with broken extensively encrusted Double-J stent, with bulky stones at both ends of the stents that had been inserted 15 years ago, after an open right pyelolithotomy, and that was lost to follow-up. Cystolithotripsy, ureteroscopic laser lithotripsy, and two consecutive mini-percutaneous nephrolithotomies were necessary to extract the stent and the patient became stone free. Conclusion: Forgotten Double-J stents for long times with extensive encrustation and stone formation can be managed safely with a combined endourologic approach with minimal morbidity.
Enhancing Geometric Fidelity of 3-Dimensional Electroanatomic Mapping During Open Chest Epicardial Radiofrequency Catheter Ablation
Authors: Gabriel E Soto, Joseph G Gibbons
Journal: J Investig Med High Impact Case Rep (2019)
Keywords: ablation, electroanatomic mapping, electrophysiology, epicardial, open chest, ventricular tachycardia
MeSH terms: Catheter Ablation, Electrophysiologic Techniques, Cardiac, Imaging, Three-Dimensional, Tachycardia, Ventricular / surgery, Case Reports, Aged, Electrocardiography, Heart Failure / complications, Humans, Male, Mitral Valve Insufficiency / complications, Pericardium / physiopathology, Pericardium / surgery, Tachycardia, Ventricular / physiopathology, User-Computer Interface

Although electroanatomic mapping techniques have been previously applied to open chest epicardial ablation procedures, such efforts have often been limited by significant geometric distortions introduced by the need to use nonstandard mapping patch placements and by intrathoracic conductance changes introduced by having the pericardial space exposed. In this article, we present a case of a patient with recurrent hemodynamically unstable ventricular tachycardia who underwent a successful open chest epicardial ablation procedure with electroanatomic mapping in which geometric distortions were minimized by judicious placement of mapping patches and the use of a saline bath within the pericardial space.
Left Atrial Ball-Shaped Thrombus with Concomitant Biatrial Appendage Thrombi in a Patient with Prior Mitral Valve Replacement
Authors: Kanako Akamatsu, Takahide Ito, Kazushi Sakane, Yumiko Kanzaki, Koichi Sohmiya, Masaaki Hoshiga
Journal: Case Rep Cardiol (2019)
MeSH terms: Case Reports

We reported a 67-year-old woman in whom large atrial thrombi were found by chance during discontinuation of therapeutic anticoagulation. The patient, with a history of mitral valve replacement surgery, had stopped anticoagulation for months because of intractable gastrointestinal bleeding, during which she was found to have 3 large thrombi in the atria on transesophageal echocardiography: left atrial free-floating ball-shaped thrombus, left atrial appendage thrombus, and right atrial appendage thrombus. One month following diagnosis, she still had the free-floating thrombus despite adequate anticoagulation. Free-floating ball-shaped thrombus is a rare finding observed on echocardiography in patients with mitral valve disease and an even rarer finding in case of appendage thrombi coexisting.