Encephalitis Associated to Metabotropic Glutamate Receptor 5 (mGluR5) Antibodies in Cerebrospinal Fluid
Authors: Carlos Guevara, Gonzalo Farias, Carlos Silva-Rosas, Pablo Alarcon, Gabriel Abudinen, Julio Espinoza, Andrés Caro, Heather Angus-Leppan, Jose de Grazia
Journal: Front Immunol (2018)
Keywords: hodgkin's lymphoma, ophelia syndrome, encephalitis, limbic encephalitis, metabotropic glutamate receptor 5
MeSH terms: Autoantibodies / cerebrospinal fluid, Encephalitis / cerebrospinal fluid, Encephalitis / diagnosis, Hashimoto Disease / cerebrospinal fluid, Hashimoto Disease / diagnosis, Immunoglobulin G / cerebrospinal fluid, Limbic Encephalitis / diagnosis, Receptor, Metabotropic Glutamate 5 / immunology, Case Reports, Aged, Encephalitis / drug therapy, Hashimoto Disease / drug therapy, Hodgkin Disease / diagnosis, Hodgkin Disease / drug therapy, Humans, Limbic Encephalitis / cerebrospinal fluid, Limbic Encephalitis / drug therapy, Male, Methylprednisolone / therapeutic use, Autoantibodies, GRM5 protein, human, Immunoglobulin G, Receptor, Metabotropic Glutamate 5, Methylprednisolone, Hashimoto's encephalitis

A 68-years-old Hispanic man, complained of night sweats, low grade fewer, unexplained weight loss, and memory problems over 3 months. Abdominal tomography showed multiple intra-abdominal adenopathy and biopsy confirmed classic Hodgkin's lymphoma. He commenced treatment with chemotherapy. Three months later, he had acute onset of inattention, auditory hallucinations and alterations of anterograde memory. The patient developed psychomotor agitation, unresponsive to a combination of neuroleptics and benzodiazepines. Brain MRI showed a small established cerebellar infarction. Electroencephalogram was normal. Tests for toxic metabolic encephalopathy were negative. One oligoclonal IgG bands was found in the Cerebrospinal fluid (CSF), which was not observed in corresponding serum, but cell count and protein were normal. Extensive testing for infectious encephalitis was unremarkable. CSF testing for commercially available neural and non-neural autoantibodies was negative. The patient fulfilled the Gultekin diagnostic criteria for paraneoplastic limbic encephalitis and methylprednisolone IV 1g/d for 5 days was given. He recovered rapidly, with progressive improvement in memory and psychomotor agitation. After treatment commenced, results for antibodies to mGluR5 in CSF taken prior to treatment were returned as positive. mGluR5 is found on post-synaptic terminals of neurons and microglia and is expressed primarily in the hippocampus and amygdala. This case highlights the difficulties in diagnosing this type of encephalitis: the CSF did not show pleocytosis, the MRI showed only chronic change and the electroencephalogram was normal. The dramatic recovery after methylprednisolone help to better characterized the clinical spectrum of auto-immune encephalitis. Diagnosing anti mGlutR5 encephalitis may lead to potentially highly effective treatment option and may anticipate the diagnostic of a cancer. A high index of suspicion is needed to avoid missed diagnosis. In patients with unexplained encephalitis, testing for antibodies to mGluR5 in CSF and serum should be considered. When there is a reasonable index of suspicion of auto-immune encephalitis, treatment should not be delayed for the antibody results.