OpenMed/multicare-articles huggingface dataset:
Peripheral T-cell lymphoma of the oral cavity: A case report
Authors: Amir Ali Asadi, Hamed Mahmoudi, Abbas Mofidi, Masoud Mortezazadeh, Alireza Hadizadeh
Journal: Cancer Rep (Hoboken) (2023)
Keywords: case report, non-hodgkin lymphoma, oral cavity, peripheral t-cell lymphoma
MeSH terms: Lymphoma, T-Cell, Peripheral / diagnosis, Lymphoma, T-Cell, Peripheral / drug therapy, Lymphoma, T-Cell, Peripheral / radiotherapy, Mouth Neoplasms / diagnosis, Mouth Neoplasms / drug therapy, Mouth Neoplasms / radiotherapy, Case Reports, Adult, Disease-Free Survival, Follow-Up Studies, Humans, Male

Background:
Peripheral T-Cell Lymphoma Not Otherwise Specified (PTCL-NOS) is a rare type of non-Hodgkin T-cell lymphoma which frequently seen in immunocompromised individuals. It is estimated that only 2% of lymphomas are located on the buccal mucosa. In this case report, we present a 34-year-old male with a PTCL diagnosis.
Case:
A 34-year-old immune-competent male presented with a buccal progressive ulcerated lesion. Histopathologic and immunohistochemical findings were compatible with PTCL-NOS and classified as stage IIEA according to the Ann Arbor staging. The patient underwent chemotherapy followed by radiotherapy. He remained disease-free after 12 months of follow-up.
Conclusion:
Although lymphoma is uncommon in the oral cavity, physicians especially dentists in ordinary dental checkups should consider persistent progressive lesions as an important differential diagnosis of lymphoma.
Plasmacytoid urothelial carcinoma of the bladder metastatic to the stomach: a case report
Authors: Philippe Nabbout, James Furr, Murugan Paari, Gennady Slobodov
Journal: Case Rep Urol (2012)

Introduction. Plasmacytoid urothelial carcinoma (PUC) of the bladder is a rare histological variant of urothelial carcinoma that was recently identified. Available data on this histological variant is limited. Case Report. We report the case of a 75-year-old man with presumed history of high-grade urothelial cancer of the bladder, treated with transurethral resection and Bacille Calmette-Guérin (BCG) in 2004. Six years after treatment of the bladder cancer, the patient underwent gastrectomy for an undifferentiated carcinoma of the stomach. On followup, patient developed right ureterohydronephrosis and peritoneal carcinomatosis. Biopsy of the bladder during stent placement revealed a plasmacytoid urothelial carcinoma of the bladder. Rereadings revealed that the initial bladder and gastric malignancies were also plasmacytoid carcinoma, indicating that, the patient had since 2004, a PUC of the bladder that spread to the stomach and peritoneal cavity. Conclusion. Plasmacytoid urothelial carcinoma of the bladder is an aggressive variant of urothelial carcinoma. Based on our case and the literature review, this tumor can be misdiagnosed because of its rarity, leading to treatment delays. Both the urologist and the pathologist need to have a high index of suspicion for PUC whenever they encounter unusual clinical and/or pathological findings.
Chronic Benign CD8+ Proliferation: A Rare Affection that Can Mimic a Lymphoma Relapse
Authors: Marcela Osovská, Andrea Janíková, Leoš Křen, Andrea Marečková
Journal: Case Rep Hematol (2019)
MeSH terms: Case Reports

Chronic benign CD8+ proliferation is a rare syndrome that can take the form of a variety of other diseases. Peripheral adenopathy, cytopenia, and infiltration of the liver, kidneys, bowels, or other organs are the most common clinical presentations of the syndrome. CD8+ expansion can be clonal and nonclonal. It generally occurs in patients with innate or acquired immunodeficiency (HIV+) or in patients receiving immunosuppressive therapy. It has been found repeatedly in patients who developed severe hypogammaglobulinemia after treatment with rituximab. Diagnosis of the disease can be difficult because it can mimic relapse of a lymphoma, and a common biopsy examination cannot identify the problem at first. The authors describe a case of a patient pretreated with rituximab who developed agammaglobulinemia and peripheral adenopathy. Biopsy of an enlarged lymph node showed "reactive lymphadenitis." Additionally, a flow-cytometric examination revealed a pathological population of CD8+ lymphocytes. The treatment, which differed from treatments of lymphoma relapse, consisted of corticosteroids and IVIG substitutions and has led to a regression of clinical symptoms. With more frequent usage of rituximab, one can expect increased occurrence of a very rare CD8+ expansion that can reliably emulate the relapse of a lymphoma.
Metformin-Associated Lactic Acidosis in a Diabetic Patient with Normal Kidney Function and Occult Cirrhosis
Authors: Jad Chidiac, Rebecca Kassab, Mirella Iskandar, Sahar Koubar, Mabel Aoun
Journal: Case Rep Crit Care (2022)
MeSH terms: Case Reports

Background:
Lactic acidosis is a well-known complication of metformin accumulation in diabetic patients with kidney failure. However, it is not usual to raise the diagnosis of metformin-associated lactic acidosis when patients have normal kidney function. The causes of metformin-induced high lactate include the accumulation of normal doses of metformin in chronic kidney disease, an overdose of this drug without kidney failure, or an increase in lactate production due to the inhibition of liver gluconeogenesis. Case Presentation. We report the case of a 61-year-old diabetic man who was brought to the emergency room in a comatose state. His family reported abdominal pain with diarrhea in the last two days. He was found to have severe lactic acidosis with normal serum creatinine. He was on a regular dose of metformin, and his family denied any other medical history or any alcohol abuse. He showed no signs of infection, his liver enzymes were slightly elevated, and he had severe anemia. His hemodynamics deteriorated quickly within hours, and an abdominal computed tomography scan revealed no abnormalities. He underwent a laparotomy that ruled out mesenteric ischemia and revealed an abnormal liver. The liver biopsy later confirmed the diagnosis of cirrhosis.
Conclusions:
We discuss here the probable causes of severe lactic acidosis and the role of metformin in exacerbating this acid-base disturbance in cirrhotic patients. Future research is needed to determine whether these patients might benefit from dialysis.
Soft-Tissue Chondroma of Anterior Gingiva: A Rare Entity
Authors: Dhana Lakshmi Jeyasivanesan, Shameena Pazhaningal Mohamed, Deepak Pandiar
Journal: Case Rep Dent (2018)
MeSH terms: Case Reports

Soft-tissue chondroma is a rare, benign, slow-growing tumor made up of heterotopic cartilaginous tissue. It occurs most commonly in the third and fourth decades in the hands and feet. Oral soft-tissue chondromas are uncommon and soft-tissue chondroma of gingiva is extremely uncommon. Here, we report an unusual case of soft-tissue chondroma of gingiva in a 50-year-old woman.
Case report: Advice for schools on managing functional tic-like behaviours
Authors: Tamsin Owen, Juliana Silva, Claire Grose, Alice Bailey, Sally Robinson, Seonaid Anderson, Amanda Ludlow, Sarah Sharp, Lucy Toghill, Tammy Hedderly
Journal: Front Psychiatry (2022)
Keywords: advice, case study, education, functional tic-like behaviours, schools, support
MeSH terms: Case Reports

There has been an increase in the occurrence of sudden onset functional tic-like behaviours in adolescents during the COVID-19 pandemic, which has had a significant impact on the affected individual's ability to engage with education. The aim of this article is to generate discussion and inform practice within schools with regard to the management of functional tic-like behaviours. An advice sheet for schools has been produced based on clinical expertise and experience of consulting with schools around the management within education settings. Case examples are presented highlighting the importance and impact of these strategies. We also highlight the need for further evaluation of the effectiveness of the advice sheet in collaboration with schools and families.
Social determinants and access to induced abortion in burkina faso: from two case studies
Authors: Ramatou Ouédraogo, Johanne Sundby
Journal: Obstet Gynecol Int (2014)

Unsafe abortion constitutes a major public health problem in Burkina Faso and concerns mainly young women. The legal restriction and social stigma make abortions most often clandestine and risky for women who decide to terminate a pregnancy. However, the exposure to the risk of unsafe induced abortion is not the same for all the women who faced unwanted pregnancy and decide to have an abortion. Drawn from a qualitative study on the issue of abortion in Ouagadougou, Burkina Faso's capital, the contrasting cases of two young women who had abortion allow us to show how the women's personal resources (such as the school level, financial resources, the compliance to social norms, the social network, etc.) may determine the degree of vulnerability of women, the delay to have an abortion, the type of care they are likely to benefit from, and the cost they have to face. This study concludes that the poorest always pay more (cost and consequences), take longer to have an abortion, and have more exposure to the risk of unsafe abortion.
Novel mutations in FKBP10 and PLOD2 cause rare Bruck syndrome in Chinese patients
Authors: Peiran Zhou, Yi Liu, Fang Lv, Min Nie, Yan Jiang, Ou Wang, Weibo Xia, Xiaoping Xing, Mei Li
Journal: PLoS One (2014)
MeSH terms: Arthrogryposis / genetics, Mutation, Osteogenesis Imperfecta / genetics, Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase / genetics, Tacrolimus Binding Proteins / genetics, Case Reports, Research Support, Non-U.S. Gov't, Adult, Arthrogryposis / pathology, Child, Humans, Male, Osteogenesis Imperfecta / pathology, Pedigree, PLOD2 protein, human, Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase, Tacrolimus Binding Proteins, FKBP10 protein, human, Bruck syndrome 1

Bruck syndrome (BS) is an extremely rare form of osteogenesis imperfecta characterized by congenital joint contracture, multiple fractures and short stature. We described the phenotypes of BS in two Chinese patients for the first time. The novel compound heterozygous mutations c.764_772dupACGTCCTCC (p.255_257dupHisValLeu) in exon 5 and c.1405G>T (p.Gly469X) in exon 9 of FKBP10 were identified in one proband. The novel compound heterozygous mutations c.1624delT (p.Tyr542Thrfs*18) in exon 14 and c.1880T>C (p.Val627Ala) in exon 17 of PLOD2 were identified in another probrand. Intravenous zoledronate was a potent agent for these patients, confirmed the efficacy of bisphosphonates on this disease. In conclusion, the novel causative mutations identified in the patients expand the genotypic spectrum of BS.
Simultaneous occurrence of follicular and papillary thyroid carcinomas in same thyroid lobe: A case series of six patients from Qatar
Authors: Abdelrahman Abdelaal, Walid El Ansari, Abdelrahman Abusabeib, Hanan Farghaly, Abdelhakem A M Tabeb
Journal: Int J Surg Case Rep (2020)
Keywords: differentiated, follicular thyroid carcinoma, papillary thyroid carcinoma

Background:
Papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) are the first and second most common thyroid cancers comprising about 85% and 10% of all thyroid cancers. Simultaneous occurrence of medullary and papillary thyroid cancer has been reported with various presentations, but simultaneous occurrence of FTC in addition to PTC as differentiated cancers, is an unusual event that is rarely reported.
Presentation of cases:
We report our experience of six rare cases of synchronous coexistence of FTC and PTC with unique features. Case 1 is 31 old Egyptian female. Case 2 is a 61 year old Sudanese male. Case 3 is a 59 year old Sudanese male. Case 4 is a 56 years old Indian female. Case 5 is a 35 years old Filipina female. Case 6 is a 52 years old Qatari female. The six cases are special in their co-occurrence of two thyroid carcinoma, consisting of histologic features of follicular thyroid carcinomas, and classical papillary thyroid carcinoma, possibly the first case series of simultaneous occurrence of these two types of thyroid cancer in the Middle East and North Africa Region.
Conclusions:
We present rare cases of concurrent FTC and PTC. These six cases add more data highlighting the coincidental simultaneous coexistence of FTC and PTC. Endocrinologists and pathologists should be aware of and vigilant to this variety.
A Successful Pregnancy Despite the Presence of an Intrauterine Fetal Bone Fragment
Authors: Evangelos Petrakis, Ioannis Chatzipapas, Ioannis K Papapanagiotou, Panagiotis Fotinopoulos, Panagiota Siemou, Konstantinos Ntzeros, Dimitrios Loutradis
Journal: Case Rep Obstet Gynecol (2019)
MeSH terms: Case Reports

Objective:
Intrauterine retention of fetal bones following a termination of a pregnancy is a rare complication. Among the few reported cases in literature, there has been no report describing the birth of a live fetus, despite the presence of an embryonic ossicle within the endometrial cavity.
Case report:
A 28-year-old woman, with an obstetrical history of a miscarriage at the 19th week of gestation, underwent a diagnostic hysteroscopy for evaluation of pelvic pain and infertility, which revealed an intrauterine embryonic ossicle. The patient did not comply with our recommendations to undergo a surgical hysteroscopy. The patient's next visit was during her 9th week of gestation. She was followed up regularly at our Obstetrics Department. Her gestation was uneventful, while an elective caesarean section at the 39th week of gestation was performed.
Conclusion:
The present clinical case has demonstrated that achieving childbearing is possible, despite the requirement of removing such bone fragments.
Successful Management of Vinblastin Overdose with Exchange Transfusion: A Case Report
Authors: M R Bordbar, A Bazrafshan, M Karimi
Journal: Iran J Ped Hematol Oncol (2015)
Keywords: exchange transfusion, overdose, vinblastin

Accidental overdose of chemotherapy drugs including vinblastin (VBL) have been reported in the literature. As VBL overdose is potentially fatal, we decided to introduce a 2-year-old girl affected by langerhans' cell histiocytosis who was accidentally injected 10-times the prescribed dose of VBL (16 mg), and was saved with whole blood double exchange transfusion at 8 and 20 hrs after the accidental injection. The earliest manifestations were irritability and sinus tachycardia which alleviated after starting digoxin and at the end of the 2(nd) exchange transfusion. Other reported adverse effects were myelosuppression, weakness of extremities, diminished deep tendon reflexes and ileus which resolved at the time of discharge from hospital on day 13 of admission. It is speculated that exchange transfusion is an effective modality in reducing the serious adverse effects of VBL overdose.
Case Report: An Internal Mammary Rhabdomyosarcoma After Mastectomy and Systemic and Radiation Therapy in a Patient With Breast Cancer
Authors: Dan-Qiong Wang, Jing-Yi Zhang, Jing Li, Jian-Ming Ying, Xiang Wang, Ying Fan, Shu-Lian Wang
Journal: Front Oncol (2021)
Keywords: breast cancer, case report, post-radiation soft tissue sarcomas, radiation therapy, rhabdomyosarcomas
MeSH terms: Case Reports

Post-radiation soft tissue sarcomas (PRSTSs) are rare secondary malignancies. In this report, we describe the clinical presentation of a 52-year-old woman who underwent postmastectomy radiation therapy (PMRT) for left-sided breast cancer 2.7 years ago and presented with a left internal mammary mass and left interpectoral nodule on computed tomography. On further evaluation, she was diagnosed with internal mammary rhabdomyosarcoma and interpectoral nodal breast cancer relapse, and was treated with chemotherapy, followed by surgery and endocrine therapy. She developed left pleural metastases and is currently receiving targeted therapy. Internal mammary rhabdomyosarcomas are rare among PRSTSs and pose a diagnostic challenge for patients with breast cancer. Histological evaluation is important for the differential diagnosis of breast cancer relapses with secondary malignancies. The management of post-radiation thoracic rhabdomyosarcomas is challenging, and the prognosis is poor.
Coexistence of Hodgkin's Lymphoma and Castleman's Disease: A Case Report with Successful Response to Chemotherapy and Radiotherapy
Authors: Amina Mohtaram, Mohammed Afif, Tanae Sghiri, Amal Rami, Rachida Latib, Fouad Kettani, Meryam Ben Ameur El Youbi, Saber Boutayeb, Tayeb Kebdani, Noureddine Benjaafar, Imane Aaribi, Hassan Errihani
Journal: Case Rep Oncol Med (2013)

Background. Castleman's disease is a rare clinicopathological entity of unknown origin. Coexistence of Hodgkin's lymphoma and Castleman's disease is rare. We report a case of Hodgkin's disease of cervical lymph nodes in a patient previously diagnosed with Castleman's disease. Case Presentation. A 43-year-old man admitted in July 2009 for a right cervical pain with lymph node at the physician examination. He underwent a right adenectomy and histological studies showed typical features of Castleman's disease. Three years after, the patient consulted for increasing the volume of cervical lymph node. Clinical examination showed a right cervical lymph node of 3 cm. The computed tomography scan of chest, abdominal and pelvic was normal. Histological and immunohistochemical studies of cervical lymph node biopsy specimen were in favor of Castleman's disease associated with Hodgkin's disease. Reed-Sternberg cells were positive for CD15 and CD30. The patient received chemotherapy based on anthracyclines, bleomycin, vinblastine, and dacarbazine (ABVD) and radiotherapy with complete response. Conclusion. Prevalence of Hodgkin's lymphoma in Castleman's disease is more difficult to establish because of the low number of cases reported in the literature.
Latanoprost Induced Iris Pigment Epithelial and Ciliary Body Cyst Formation in Hypermetropic Eyes
Authors: Abhijit Anand Mohite, Rangarajan V Prabhu, Thomas Ressiniotis
Journal: Case Rep Ophthalmol Med (2017)
MeSH terms: Case Reports

Purpose:
Latanoprost has become one of the most widely prescribed topical antihypertensive medications in recent years. Yet there have been few reports of secondary iris pigment epithelial (IPE) and ciliary body (CB) cyst formation to date and none, to our knowledge, reported in eyes predisposed to primary angle closure.
Methods:
We report the first documented case of bilateral IPE and CB cysts in a hypermetropic patient with prior laser peripheral iridotomies (LPIs) as a rare, delayed side effect of topical Latanoprost treatment. The cysts subsided with discontinuation of Latanoprost, thereby demonstrating a causal relationship. We discuss the pathogenesis of such cysts and advocate using of serial ultrasound biomicroscopic (UBM) images to monitor them.
Results and conclusions:
Latanoprost may cause iris pigment epithelial and ciliary body cysts that remain clinically undetected. In eyes predisposed to angle closure, such cysts may become clinically detectable and masquerade as iris tumours. Prior laser peripheral iridotomies in these eyes may delay or prevent the detection of these cysts. Ultrasound biomicroscopy (UBM) imaging is therefore a valuable tool in diagnosing and monitoring these cysts.
Hyponatremia: An Unusual Presentation in a Neonate With Chromosome 1q21.1 Deletion Syndrome
Authors: Bakri Alzarka, Rachel Usala, Matthew T Whitehead, Sun-Young Ahn
Journal: Front Pediatr (2018)
Keywords: siadh, hyponatremia, hypothalamus, neonate, tolvaptan
MeSH terms: Case Reports

Chromosome 1q21.1 deletion syndrome is associated with a wide variety of clinical features including mild to moderate mental retardation, microcephaly, cardiac abnormalities, and cataracts. We report an unusual case of a premature neonate with persistent hyponatremia, markedly elevated plasma arginine vasopressin level (32.7 pg/mL), and clinical findings consistent with the syndrome of inappropriate antidiuretic hormone secretion (SIADH). The patient, who also had microcephaly and dextrocardia, was subsequently diagnosed with chromosome 1q21.1 deletion syndrome. Further evaluation revealed hypothalamic abnormalities, features not previously described with this syndrome. To our knowledge, this is the first report of SIADH associated with congenital hypothalamic anomalies in a neonate with chromosome 1q21.1 deletion syndrome. We also report our experience using tolvaptan, a vasopressin receptor antagonist, in this patient to effectively maintain eunatremia.
A Dog with Pseudo-Addison Disease Associated with Trichuris vulpis Infection
Authors: Luigi Venco, Valentina Valenti, Marco Genchi, Giulio Grandi
Journal: J Parasitol Res (2011)
MeSH terms: Case Reports

A female Rottweiler dog was presented with a history of intermittent vomiting and diarrhoea, dysorexia, weakness, and weight loss. Haemocytometry and biochemistry values were within normal ranges except for electrolyte analyses, that demonstrated hyponatremia and hyperkalemia with a decreased sodium/potassium ratio. A diagnosis of hypoadrenocorticism was suspected. Basal and post-ACTH stimulation cortisolemia were within the normal values. Electrocardiography was normal, and thoracic radiography showed no significant modifications. On abdominal ultrasonography, adrenal glands appeared normal, while the bowel was distended, and several thin linear hyperechoic objects floating in the lumen were observed. Two adult female whipworms (Trichuris vulpis) were collected following bowel irrigation. Anthelmintic treatment against the parasite was curative.
Unusual Etiology and Diagnosis of Oroantral Communication due to Late Implant Failure
Authors: Rabah Nedir, Nathalie Nurdin, Marion Paris, Marc El Hage, Semaan Abi Najm, Mark Bischof
Journal: Case Rep Dent (2017)
MeSH terms: Case Reports

Oroantral communication (OAC) rarely occurs long after implant placement. The present report describes the rare etiology and the difficulty of the diagnosis of an uncommon OAC occurring 10 years after the implant placement in the posterior maxilla. The difficulty of the diagnosis lies in the absence of clinical symptoms of sinusitis and presence of multiunit prosthesis hiding implant failure. This case report supports the need for sinus check-up during a routine implant examination.
Ectopic Thyroid Mass Separately Present in Mediastinum and Not a Retrosternal Extension: A Report of Two Cases
Authors: Abdul Ahad Sohail, Syed Shahabuddin, Moghira Iqbaluddin Siddiqui
Journal: Case Rep Surg (2019)
MeSH terms: Case Reports

Retrosternal extension of goiter is one of the most common types of masses in the superior mediastinum. These types of goiters classically present with compressive symptoms such as dyspnea, dysphonia, dysphagia, or sleep apnea. Surgical treatment with a total thyroidectomy and complete removal of the intrathoracic portion of thyroid is the gold standard treatment. These cervicomediastinal lesions at times may not be continuous, and a sternotomy may be required for complete and safe excision of the mediastinal mass to achieve decompression of the surrounding structures and preventing the hemorrhagic complications if attempted from cervical incision. We present a summary of two cases that gave an initial impression of retrosternal extension of thyroid gland, however intraoperatively were found to be separately encapsulated and required sternotomy for its safe and complete excision.