OpenMed/multicare-articles huggingface dataset:
A Case of Trousseau's Syndrome Accompanying Ovarian Cancer with Widespread Thromboembolisms
Authors: Hiroharu Kobayashi, Yoshifumi Arai, Kentaro Iga, Misa Kobayashi, Takashi Suzuki, Satoru Nakayama, Hiroshi Adachi
Journal: Case Rep Obstet Gynecol (2020)
MeSH terms: Case Reports

The patient was a 41-year-old woman, gravida 0. She had no notable medical history. Laparoscopic right salpingo-oophorectomy and left cystectomy were performed for bilateral ovarian endometriomas, which were both pathologically diagnosed as benign. Six months later, she presented with left lower abdominal pain and expressive aphasia. Examination revealed multiple cerebral infarctions and pulmonary embolism. The patient was diagnosed with Trousseau's syndrome secondary to ovarian cancer, and anticoagulant therapy was initiated. Despite treatment, she developed visual field loss due to occlusion of the left retinal artery; dizziness due to cerebellar infarction and myocardial infarction; and right hemiplegia due to new cerebral infarction. She received chemotherapy (two courses of paclitaxel and carboplatin), which did not improve her condition, and died two months after onset. An autopsy revealed that her left ovary was enlarged to a size of 12 cm and an endometrioid carcinoma G2 was identified. Ovarian cancer had spread throughout the abdominal cavity, and a large amount of pleural and ascites fluid was present. Multiple thrombi were found in bilateral pulmonary arteries and bilateral common iliac veins. There was a 2.5 cm thrombus in the left ventricle apex, and the anterior descending branch was obstructed by thrombus with recanalization.
Cardiac pacemaker-related endocarditis complicated with pulmonary embolism: Case report
Authors: Dalila Šačić, Olga Petrović, Danijela Zamaklar-Trifunović, Branislava Ivanović
Journal: Front Cardiovasc Med (2023)
Keywords: staphylococcus, embolism, endocarditis, pacemaker, vegetation
MeSH terms: Case Reports

Cardiac device-related endocarditis as a device-therapy complication is a growing problem due to higher life expectancy and the increasing number of abandoned leads and subclinical symptoms. We reported a case of a 47-year-old woman with an implanted pacemaker who was admitted to the clinic for cardiology due to the right-sided device-related infective endocarditis of the pacemaker leads with vegetations, predominantly in the right atrium and right ventricle and complicated by pulmonary embolism. Several years after pacemaker implantation, she was diagnosed with systemic lupus erythematosus and started immunosuppressive therapy. The patient was treated with prolonged intravenous antibiotic therapy. The atrial and ventricular lead was extirpated, and the posterior leaflet of the tricuspid valve was shaved.
A series of patients with unusual lung cancers with unusual presentations
Authors: D M Maphanga
Journal: Afr J Thorac Crit Care Med (2019)
Keywords: cancer, lung
MeSH terms: Case Reports

Lung malignancies have become increasingly prevalent. Occasionally, an unusual tumour is diagnosed, or a common tumour type presents unusually. This case report reviews 3 cases of thoracic neoplasm, including two cases of uncommon cancers (primary lung adenoid cystic carcinoma and thoracic desmoplastic small round cell high-grade sarcoma) and an atypical presentation of malignant mesothelioma.
Intra-Articular Giant Heterotopic Ossification following Total Knee Arthroplasty for Charcot Arthropathy
Authors: Arata Nakajima, Shintaro Tsuge, Yasuchika Aoki, Masato Sonobe, Yoshifumi Shibata, Yu Sasaki, Koichi Nakagawa
Journal: Case Rep Orthop (2013)

Although the Charcot arthropathy may be associated with serious complications, total knee arthroplasty (TKA) is the preferred choice of treatment by patients. This case report presents an 80-year-old man with intra-articular giant heterotopic ossification following loosening of femoral and tibial implants and femoral condylar fracture. He had undergone TKA because of Charcot neuropathy seven years ago and had been doing well since. Immediately after a left knee sprain, he became unable to walk. Because he had developed a skin ulcer on his left calf where methicillin-resistant Staphylococcus aureus was detected, we postponed revision surgery until the ulcer was completely healed. While waiting, intra-articular bony fragments grew larger and formed giant heterotopic ossified masses. Eventually, the patient underwent revision surgery, and two major ossified masses were carefully and successfully extirpated. It should be noted that intra-articular heterotopic giant ossification is a significant complication after TKA for neuropathic arthropathy.
Radiation Recall Pneumonitis Induced by Anti-PD-1 Blockade: A Case Report and Review of the Literature
Authors: Yu Chen, Zhaoqin Huang, Ligang Xing, Xiangjiao Meng, Jinming Yu
Journal: Front Oncol (2020)
Keywords: camrelizumab, anti-pd-1 blockade, immunotherapy, radiation recall pneumonitis (rrp), thoracic radiation
MeSH terms: Case Reports

Background: Radiation recall pneumonitis (RRP) is an unpredictable but relatively severe subclinical radiation damage which occurs in the previously irradiated fields of pulmonary tissue after administration of a systemic agent. Previous reports of RRP were mainly attributed to chemotherapy and molecular-target agents. RRP induced by immunotherapy has been rarely reported. Here we describe a case of a novel pattern of RRP induced by anti-PD-1 blockade Camrelizumab 2 years after radiotherapy, with some focus on further understanding of this phenomenon. Case Report: A 64-year-old man with non-small cell lung cancer (NSCLC) received two cycles of chemotherapy with cisplatin and pemetrexed first. Subsequently, he underwent concomitant chemoradiotherapy with cisplatin and pemetrexed to simultaneous integrated boost (SIB) radiotherapy. After 15 months, due to tumor progression and brain metastasis, he started with administration of anti-PD-1 blockade Camrelizumab (200 mg q2w) and stereotactic radiosurgery (SRS). The patient developed fever, dyspnea and cough after the eighth administration of Camrelizumab. Meanwhile, his chest CT revealed patchy consolidation and ground-glass opacities localized within the previously irradiated area. Subsequent treatment regimen was adjusted to 80 mg q12h prednisolone with discontinuation of Camrelizumab. Then the symptoms gradually eased and reexamination of CT showed significant improvement in RRP after 2 weeks. Conclusion: Our case report presents a novel pattern of RRP induced by anti-PD-1 blockade Camrelizumab 2 years after radiotherapy. This indicates that previous radiotherapy combined with subsequent anti-PD-1 blockade has a potential to cause overlapping damage to lung, suggesting that intensive attention might be needed for patients who are treated with anti-PD-1 blockade in conjunction with a prior history of thoracic radiation.
A Case of Drug-Induced Liver Injury Secondary to Natalizumab
Authors: Phillip P Santoiemma, Haripriya Maddur, Christopher M Moore
Journal: Case Reports Hepatol (2020)
MeSH terms: Case Reports

A 33-year-old Caucasian female with relapsing-remitting multiple sclerosis presented with abdominal pain, nausea, and vomiting and was found to have acute liver injury. After thorough investigation, she was diagnosed with drug-induced liver injury (DILI) thought secondary to redosing of Natalizumab therapy.
A Challenging Case of Severe Ulcerative Colitis following the Initiation of Secukinumab for Ankylosing Spondylitis
Authors: Dean Ehrlich, Nimah Jamaluddin, Joseph Pisegna, David Padua
Journal: Case Rep Gastrointest Med (2018)
MeSH terms: Case Reports

Secukinumab is an interleukin-17 inhibitor used for the treatment of ankylosing spondylitis (AS), psoriasis, and psoriatic arthritis. The risk of exacerbating underlying inflammatory bowel disease (IBD) in patients being treated with secukinumab for other conditions is controversial. We document a patient with AS and previously undiagnosed IBD, found to be in a severe ulcerative colitis flare shortly after receiving the loading dose of secukinumab. There are no guidelines regarding biologic salvage therapy for IBD in the setting of active treatment with another biologic agent. After waiting one half-life of secukinumab, our patient had an excellent response to initiation of infliximab.
Multiple Venous Malformations as a Cause of Pulsatile Tinnitus
Authors: Ayham Al Afif, Uthman Alamoudi, Ahmed A Al-Sayed, Manohar Bance
Journal: Case Rep Otolaryngol (2020)
MeSH terms: Case Reports

Introduction:
Pulsatile tinnitus is a relatively common presentation in otolaryngology clinics, most cases of which have a treatable cause. This presentation warrants a thorough workup to identify treatable, and rule out life-threatening, etiologies. We present a case of a patient with pulsatile tinnitus arising from multiple dilated venous channels in the head and neck. Case Presentation. We present the case of a 65-year-old Caucasian female with a two-year history of progressive, bilateral pulsatile tinnitus, which had become debilitating. Computed-tomographic angiography (CTA) studies ruled out an intracranial vascular cause for her symptoms. However, computed tomography (CT) scanning and magnetic resonance imaging (MRI) revealed multiple dilated bilateral, low-flow, venous channels throughout the head and neck. The proximity of such dilated venous channels to the temporal bone provides a route for sound to be transmitted to the inner ear.
Conclusion:
Arterial, venous, and systemic etiologies can cause pulsatile tinnitus. Arteriovenous malformations (AVMs) of the head and neck represent less than 1% of cases. In our patient, dilated low-flow venous malformations are the likely source of her symptoms, which is the first reported case in the literature.
Prednisolone-induced virginal mammary hypertrophy: Case report
Authors: Samir Jabaiti, Luma Fayyad, Ula Isleem
Journal: Int J Surg Case Rep (2019)
Keywords: case report, mammaplasty, prednisolone, virginal mammary hypertrophy

Introduction:
Virginal mammary hypertrophy (VMH) is a rare benign disorder of the breast characterized by excessive enlargement of one or both breasts. It usually presents during adolescence. Drug-induced VMH has been scarcely reported in case reports. Review of the literature showed that prednisolone-induced gigantomastia was reported in a single study on a 47-year-old female. In this study, a case of VMH in a 17-year-old girl following prednisolone treatment will be described. Clinical presentation, clinical findings, diagnostic work-up, management and follow up are discussed.
Presentation of case:
A 17-year-old, single female presented to the plastic surgery department at our institute with progressive enlargement of both breasts, 2 months following treatment with prednisolone. Incisional biopsy excluded other breast differential diagnoses. The patient was managed surgically with bilateral mammaplasty with free nipple-areola graft. A total of 8.325 kg of breast tissue was resected. Follow-up 48 months postoperatively revealed good patient satisfaction with no recurrence of breast hypertrophy.
Discussion:
Although the estrogen theory is regarded as the most credible explanation for VMH, several cases of drug-induced mammary hypertrophy have been reported. This study may be the first reported case of adolescent prednisolone-induced VMH. Mammaplasty is an accepted treatment despite its possible association with a higher recurrence rate.
Conclusion:
VMH may be a rare complication of prednisolone treatment. It should be considered in patients presenting with breast hypertrophy following steroid administration.
Intranodal palisaded myofibroblastoma: a case report from an unusual site
Authors: Laraqui Hicham, Mouna Khmou, Mohammed Najih, Fouad Zouaidia, Khalid Sair, Basma El Khannoussi
Journal: Pan Afr Med J (2015)
Keywords: intranodal palisaded myofibroblastoma, lymph node, retroperitoneum
MeSH terms: Lymph Nodes / pathology, Neoplasms, Germ Cell and Embryonal / pathology, Neoplasms, Muscle Tissue / diagnosis, Testicular Neoplasms / pathology, Case Reports, Adult, Diagnosis, Differential, Humans, Laparotomy, Male, Neoplasms, Muscle Tissue / pathology, Tomography, X-Ray Computed, Testicular Germ Cell Tumor

Intranodal palisaded myofibroblastoma is a rare lymph node benign tumor, of unknown pathogenesis. Although benign, this lesion is frequently confused with metastatic lesions, especially in atypical sites. We report a 39-year-old man with a history of testicular malignant mixed germ cell tumor, presented with abdominal painless mass. The computed tomography of the abdomen confirmed the presence of 180 × 140 mm2 mass in the retroperitoneum with lympadenopathy on the right measuring 20 x 15 mm. The patient underwent exploratory laparotomy, and a surgical exerese of the retroperitoneeum lymph node was made. Histological and immunohistochemical examination confirmed the diagnosis of intranodal palissaded myofibroblastoma. This entity has been previously described, only once, in retroperitoneal region. Despite to the rarity of this neoplasm, we discuss clinicopathologic features and differential diagnosis.
Video-assisted thoracoscopic surgery for bilateral intralobar pulmonary sequestration
Authors: Norichika Iga, Hideyuki Nishi, Shinichiro Miyoshi
Journal: Int J Surg Case Rep (2018)
Keywords: intralobar pulmonary sequestration, limited resection, thoracoscopic surgery

Introduction:
Intralobar pulmonary sequestration (ILS) is a rare congenital malformation, and is supplied by an aberrant systemic artery. The conventional surgical resection for ILS is lobectomy through an open thoracotomy. However, lobectomy might lead to a significantly compromised pulmonary function. There have been some reports on the feasibility or advantages of the VATS approach in recent years. We report a rare case where we performed a two staged segmentectomy and wedge resection of the affected lesions using a VATS approach for bilateral ILS, and achieved a successful outcome.
Case presentation:
A 30-year-old woman was diagnosed with pneumonia. Chest CT showed multiple cystic masses containing fluid, in the posterobasal segment of the right lung and a hyper infiltrated area in the identical segment of the left lung. 3D CT angiography showed that the area of the right sided lesion received its blood supply from the left gastric artery and the area of the left sided lesion from the proximal celiac artery. The patient was diagnosed with bilateral ILS, and a staged, sequential lung resection was planned using the VATS approach. Anatomical basilar segmentectomy with VATS minithoracotomy for the right ILS, and resection of only the sequestrated lung by VATS for the left ILS were performed.
Conclusions:
It is important to plan the surgical treatment strategy for bilateral ILS for the preservation of respiratory function. Limited resection using the VATS approach for bilateral ILS can be performed safely and might be useful as a minimally invasive surgery.
Case report: De novo SAMD9L truncation causes neonatal-onset autoinflammatory syndrome which was successfully treated with hematopoietic stem cell transplantation
Authors: María Soledad Caldirola, Analía Gisela Seminario, Paula Carolina Luna, Renata Curciarello, Guillermo Horacio Docena, Nicolás Fernandez Escobar, Guillermo Drelichman, Marco Gattorno, Adriana A de Jesus, Raphaela Goldbach-Mansky, María Isabel Gaillard, Liliana Bezrodnik
Journal: Front Pediatr (2023)
Keywords: candle-like syndrome, samd9l, autoinflammatory syndromes, case report, primary immunodeficiencies, sterile alpha motif domain containing 9 like
MeSH terms: Case Reports

During recent years, the identification of monogenic mutations that cause sterile inflammation has expanded the spectrum of autoinflammatory diseases, clinical disorders characterized by uncontrolled systemic and organ-specific inflammation that, in some cases, can mirror infectious conditions. Early studies support the concept of innate immune dysregulation with a predominance of myeloid effector cell dysregulation, particularly neutrophils and macrophages, in causing tissue inflammation. However, recent discoveries have shown a complex overlap of features of autoinflammation and/or immunodeficiency contributing to severe disease phenotypes. Here, we describe the first Argentine patient with a newly described frameshift mutation in SAMD9L c.2666delT/p.F889Sfs*2 presenting with a complex phenotypic overlap of CANDLE-like features and severe infection-induced cytopenia and immunodeficiency. The patient underwent a fully matched unrelated HSCT and has since been in inflammatory remission 5 years post-HSCT.
Unusual Complication following a Myomectomy: Colic Migration of a Forgotten Abdominal Swab
Authors: Boyodi Tchangai, Fousseni Alassani, Mazamesso Tchaou
Journal: Case Rep Surg (2017)
MeSH terms: Case Reports

Surgical sponges are the most common retained foreign bodies following surgery. The morbidity of this condition is illustrated herein with the case of a 36-year-old female patient with a history of myomectomy 5 months before her admission into our unit for enterocutaneous fistula. Although imaging and etiological investigations were made, diagnosis was carried out only by laparotomy. The foreign body found was an abdominal swab that migrated from abdominal cavity to the colon causing several intestinal injuries. The lack of specific clinical signs and the death of the patient raise the necessity of preventing these complications that involve the surgeon liability.
Radiological Manifestations of Ketamine Abuse
Authors: Amin Da'meh, Alexandre Al-Awa, Sadeq Da'meh
Journal: J Belg Soc Radiol (2021)
Keywords: ketamine, abuse, computed tomography, cystitis, hydronephrosis, pneumomediastinum
MeSH terms: Case Reports

Teaching point: Awareness of the radiological manifestations helps recognition of ketamine abuse.
Retinoblastoma in Adults: Clinical Features, Gene Mutations and Treatment Outcomes: A Study of Six Cases
Authors: Nan Zhou, Lihong Yang, Xiaolin Xu, Yueming Liu, Wenbin Wei
Journal: Front Oncol (2022)
Keywords: clinical features, genetic analysis, onset in adult, retinoblastoma, treatment outcomes

Purpose:
To report six Asian adult patients with retinoblastoma (RB).
Design:
Retrospective and observational small case series.
Participants:
Six patients with a white dome-shaped tumor of the retina were evaluated from May 10, 1995, to September 10, 2021.
Main outcome measures:
Initial tumor and associated fundus features, pathology, gene mutation, treatment, tumor course on follow-up, and salvage globe outcome.
Results:
The six affected Asian patients consisted of three men and three women. The mean age at the time of diagnosis was 36.5 years (median: 31 years, range: 20-55 years). All patients were unilateral. In all cases, the tumors were white, dome-shaped, with full-thickness retinal involvement, and mushroom-like protrusions into the vitreous cavity. The mean tumor thickness measured by ultrasonography was 4.5 mm (median: 3.2 mm, range: 3.2-6.8 mm). Associated characteristic symptoms included dilated retinal feeding artery and draining vein (100%), surrounding subretinal infiltration (83%), exudative retinal detachment (83%), and vitreous seeds (67%). Local tumor resection was performed in three patients, I-125 plaque brachytherapy combined with transpupillary thermotherapy (TTT) and intravitreous injection of melphalan (combination treatment) in one patient, I-125 plaque brachytherapy in two patients, and enucleation in one (20%) patient. RB1 gene testing was carried out on four patients and pathological diagnosis on five patients. Genetic analysis revealed that the RB1 mutation was a mosaic c.709dupG (p.Glu237GlyfsTer4) duplication in one patient, a mosaic c.763C>T(p.Arg255Ter) mutation in another patient, while the remaining two patients were RB1 negative. At the end of the follow-up, none of the patients had developed tumor-related metastasis or died. The findings were consistent in all patients who had an adequate follow-up. This study focused on this rare lesion to distinguish it from other intraocular white lesions in adults, including choroidal osteoma, vitreoretinal lymphoma, and retinal capillary hemangioma, all of which are different clinical entities.
Conclusion:
In adults, RB is typically a white, full-thickness retinal mass that is unilateral, often combining with retinal feeding vessels, subretinal infiltration, and vitreous seeds. Genetic studies on adult-onset RB are essential and still require elucidation. Despite RB being a malignant tumor, patient survival was minimally affected.
A Rare Case of Esophageal Adenocarcinoma with Urinary Bladder Metastasis
Authors: Heather Katz, Rahoma E Saad, Krista Denning, Toni O Pacioles
Journal: Case Rep Gastrointest Med (2017)
MeSH terms: Case Reports

Metastatic esophageal adenocarcinoma to the urinary bladder is extremely rare. We describe a previously healthy 49-year-old female with recent diagnosis of adenocarcinoma of the gastroesophageal junction with metastatic disease to the liver. Biopsy was positive for human epidermal growth factor receptor 2 (HER2) by Fluorescence In Situ Hybridization (FISH). She received six cycles of Cisplatin, 5-Fluorouracil, and Herceptin and subsequently developed symptomatic anemia and hematuria. Cystoscopy with retroflexion was performed and she received a transurethral resection of bladder tumor with fulguration. Pathology of the bladder tumor revealed similar morphology to her liver metastasis and immunohistochemical stains were consistent with metastatic esophageal cancer. Three weeks after being diagnosed with metachronous urinary bladder metastasis from esophageal adenocarcinoma primary, she expired. She only received her first cycle of palliative chemotherapy with Ramucirumab and Paclitaxel.
Taxus baccata intoxication: the sun after the electrical storm
Authors: Alexandre Pinto, Tiago Lemos, Inês Silveira, Irene Aragão
Journal: Rev Bras Ter Intensiva (2021)
MeSH terms: Taxus, Case Reports, Humans, Plant Leaves

European yew (Taxus baccata) is a tree with alternate branchlets, green needles and reddish-brown bark. A high-dose ingestion of Taxus baccata for suicidal purposes usually results in death. The systemic toxicity is mainly cardiac. The authors describe the case of a young patient who ingested a high dose of yew needles and presented to the emergency department with a serious intoxication, which manifested as a chaotic malignant arrhythmia that was successfully treated after exhaustive supportive care.
Idiopathic giant abdominal lymph cyst: a case report
Authors: Thorsten H Ecke, Holger Gerullis, Christoph J Heuck, Steffen Hallmann, Carsten Lange, Jürgen Ruttloff
Journal: J Med Case Rep (2011)

Introduction:
Giant lymph cysts are a relatively frequent complication after surgical procedures in the abdomen, often after kidney transplantation, but there are also cases after pelvic surgery such as lymphadenectomy and others. In the recent literature, there have been no reported cases of idiopathic giant lymphocyst.
Case presentation:
We present the case of a 76-year-old Caucasian man who had a lymph cyst he had known of for more than 15 years. Laparoscopic treatment was necessary because of hydronephrosis of the left kidney.
Conclusion:
This case shows that laparoscopic drainage and partial resection of the lymph cyst is a safe and effective treatment.