OpenMed/multicare-articles huggingface dataset:
A Case of Contralateral Pneumothorax, Pneumomediastinum, and Pneumopericardium after Dual-Chamber Pacemaker Implantation
Authors: Wajeeh Ur Rehman, Altif Muneeb, Usama Sakhawat, Pranava Ganesh, Nabil Braiteh, Vince Skovira, Waseem Sajjad, Afzal Ur Rehman
Journal: Case Rep Cardiol (2022)
MeSH terms: Case Reports

As permanent pacemaker implantation is increasingly becoming a common practice, it is important to understand potential complications associated with the procedure. We present a 78-year-old Caucasian female who developed contralateral pneumomediastinum, pneumothorax, and pneumopericardium after undergoing implantation of a dual-chamber pacemaker.
Gaucheroma of Mesenteric Lymph Nodes and Their Ultrasound Appearance: A Case Report
Authors: Thomas Saliba, Paolo Simoni, Aurélie Empain, Alessandro De Leucio
Journal: J Belg Soc Radiol (2023)
Keywords: gaucheroma, gaucher’s disease, diagnosis, lymph node, ultrasound
MeSH terms: Case Reports

Gaucher disease represents the largest lysosomal storage disease group worldwide. Possible complications include the development of Gaucheromas, pseudotumors resulting from an accumulation of Gaucher cells. Gaucheromas can affect the liver, spleen, bones, and lymph nodes. Descriptions of the appearance of lymph node gaucheromas exist for computed tomography (CT) and magnetic resonance imaging (MRI) but not, to our knowledge, of their ultrasound characteristics. We present the case of a four-year-old boy with Gaucher disease with lymph node Gaucheromas, discovered during a routine follow-up, and present their ultrasound characteristics. We describe characteristic ultrasound findings of non-B-cell lymphomas and Gaucheroma lymph nodes in comparison. Teaching point: Lymph node Gaucheromas have a characteristic ultrasound appearance and should be searched for in Gaucher's patients.
Sclerosing polycystic adenosis of the retromolar pad area: a case report
Authors: Sepideh Mokhtari, Saede Atarbashi Moghadam, Abbas Mirafsharieh
Journal: Case Rep Pathol (2014)

Sclerosing polycystic adenosis is a rare pathological lesion that affects salivary glands. The majority of cases involve the parotid and its occurrence in minor glands is exceedingly rare. Here, we report the first case of this lesion in the retromolar pad area and discuss its histological features and immunohistochemical reactivity with α SMA and Ki67 markers. A review of the literature on its immunohistochemical profile is also provided. Sclerosing polycystic adenosis has a diverse histomorphology and should be differentiated from other more important pathologic lesions.
Potential Benefits of Allogeneic Haploidentical Adipose Tissue-Derived Stromal Vascular Fraction in a Hutchinson-Gilford Progeria Syndrome Patient
Authors: Jaewoo Pak, Jung Hun Lee, Jeong Ho Jeon, Young Bae Kim, Byeong Chul Jeong, Sang Hee Lee
Journal: Front Bioeng Biotechnol (2020)
Keywords: hutchinson–gilford progeria syndrome, adipose tissue, insulin-like growth factor 1, progerin, stromal vascular fraction
MeSH terms: Case Reports

Hutchinson-Gilford progeria syndrome (HGPS) is a rare, fatal, and genetic disorder in the LMNA gene encoding for prelamin A. Normally, prelamin A is processed to become lamin A protein. In HGPS patients, there is a heterozygous mutation in LMNA gene, in which there is a deletion of genetic codes responsible for 50 amino acids at the C-terminus of prelamin A. The processing of the abnormal prelamin A results in abnormal lamin A protein, called progerin, causing symptoms of accelerated early aging, probably due to the inflammaging process. It is well known that adipose tissue-derived mesenchymal stem cells (MSCs) have anti-inflammatory effects by modulating inflammatory cytokines and by extracellular vesicles. Here, we present a case of an HGPS patient who responded positively to injections of allogeneic haploidentical adipose tissue-derived stromal vascular fractions containing MSCs by showing rapid height and weight growth along with increased blood level of insulin-like growth factor 1.
Functional Olfactory Nerve Regeneration Demonstrated by Thallium-201 Olfacto-Scintigraphy in Patients with Traumatic Anosmia: A Case Report
Authors: Rong-San Jiang, Yu-Yu Lu
Journal: Case Rep Otolaryngol (2019)
MeSH terms: Case Reports

Head trauma is one of the most common etiologies of olfactory dysfunction. It is difficult to use either the olfactory function test or magnetic resonance imaging to directly assess the course of damage to olfactory nerves. Thallium-201 (201Tl) olfacto-scintigraphy has been shown to be an able means for objectively assessing the olfactory nerve transport function. It is expected to be used to evaluate olfactory nerve regeneration after damage to the olfactory nerves. However, no such result has been reported. We present a patient who lost his olfactory function after experiencing head trauma. When his olfactory function remained anosmic, a 201Tl olfacto-scintigraphy showed no migration of 201Tl from the nasal mucosa to the olfactory bulb. After treatment with medicines and olfactory training, his olfactory function improved. A second 201Tl olfacto-scintigraphy showed an increased migration of 201Tl from the nasal mucosa to the olfactory bulb.
Intramuscular hemangioma in lip treated with sclerotherapy and surgery
Authors: Vanessa A Silva, Nádia L Lima, Ana Terezinha M Mesquita, Esmeralda Maria da Silveira, Flaviana D Verli, João Luiz de Miranda, Cássio Roberto R Santos, Sandra A Marinho
Journal: Case Rep Dent (2011)
MeSH terms: Case Reports

Intramuscular hemangioma is a relatively rare, benign tumor of vascular origin, accounting for less than 1% of all hemangiomas. This paper reports a case of a 48-year-old female patient with intramuscular hemangioma in the upper lip, treated with sclerotherapy and subsequent complementary surgery.
The Conundrum of Septic Shock Imitators in Patients with Hematologic Cancers: Case Presentation and Possible Differential Diagnoses
Authors: Giorgio Berlot, Giulia Moratelli, Martina Tarchini, Katiuscia Battaglia, Paolo Grassi, Nadia Zarrillo, Vincenzo Colella, Rossana Bussani
Journal: Case Rep Crit Care (2019)
MeSH terms: Case Reports

The authors describe the case of a patient treated with several cycles of chemotherapy due to an advanced stage non-Hodgkin lymphoma. One daafter the last cycle, he was admitted to our Intensive Care Unit with a septic shock-like clinical picture which didn't respond to the aggressive treatment and the patient died a few hours later. The autoptical findings cast some doubts on the diagnosis, and demonstrated the presence of other factors imitating its symptoms. In this article, the mimickers of septic shock are reviewed and discussed, as some of them require an aggressive immunosuppression instead of the recommended treatment for septic shock.
Safety and Efficacy of Combined Yttrium 90 Resin Radioembolization with Aflibercept and FOLFIRI in a Patient with Metastatic Colorectal Cancer
Authors: Andre De Souza, Kevin Pelham Daly, James Yoo, Muhammad Wasif Saif
Journal: Case Rep Oncol Med (2015)

Background. When associated with isolated four or fewer liver foci, metastatic colorectal cancer is amenable to surgical resection. Alternative therapeutic methods for isolated liver metastases include radioembolization with yttrium 90 (Y90) and transarterial chemoembolization (TACE). We present here a case of a patient with two sites of liver metastatic disease from colorectal cancer who underwent Y90 radioembolization combined with aflibercept and FOLFIRI. Case Report. A 56-year-old female with history of bilateral breast cancer and metastatic colon cancer with prior hemicolectomy and 4 previous chemotherapy regimens developed liver metastasis. She was started on aflibercept and FOLFIRI and concurrently underwent two treatments of radioembolization with Y90, initially targeting the largest right lobe tumor, and then a subsequent treatment targeting the smaller left lobe tumor with retreatment of the right lobe tumor. Her liver metastases exhibited partial response on imaging utilizing the modified RECIST criteria. Interestingly, the patient CEA levels decreased after the procedure. Discussion. This is the first reported case of a patient managed with radioembolization with Y90 combined with aflibercept, an anti-VEGF treatment, and FOLFIRI. An ongoing randomized clinical trial aims to define the role of combined targeted therapy and chemotherapy with radioembolization with Y90.
Small Cell Variant of Intravascular Large B-Cell Lymphoma: Highlighting a Potentially Fatal and Easily Missed Diagnosis
Authors: Mahboubeh Rahmani, Stephanie Halene, Mina L Xu
Journal: Biomed Res Int (2018)
MeSH terms: Lymphoma, Large B-Cell, Diffuse / diagnosis, Lymphoma, Large B-Cell, Diffuse / pathology, Case Reports, Adult, Aged, Aged, 80 and over, Biopsy, Demography, Female, Follow-Up Studies, Humans, Liver / pathology, Male, Middle Aged

Context:
Intravascular large B-cell lymphoma (IVLBCL) is a rare non-Hodgkin B-cell lymphoma with a poor prognosis. While typically described as comprising large atypical cells restricted to the lumina of small blood vessels, it can show variability in cell size.
Objective:
To report the clinicopathologic features of the IVLBCL with small cell morphology and discuss the practical implications of our findings.
Design:
We searched our archives for all IVLBCL diagnosed in our institution for the last 25 years (1992-2017). Slides were reviewed independently by two hematopathologists.
Results:
We found a total of 11 cases of IVLBCL. Bone marrow, brain, lymph node, pericardium, small bowel, and fallopian tube and ovary were the organs in which the lymphoma was initially diagnosed. One of the cases initially diagnosed in the marrow showed intrasinusoidal involvement by a small cell lymphoma; the diagnosis was confirmed by random skin biopsies showing intravascular large cells with the same phenotype. Retrospective review of the liver on this case also showed the intrasinusoidal involvement by the disease consisting of small cells. In another case, IVLBCL that was initially diagnosed in a small bowel biopsy was retrospectively found in a breast biopsy, but with small cell morphology.
Conclusions:
Our findings suggest that, in the presence of high clinical suspicion, IVLBCL should be high in the differential diagnosis when lymphoma is predominantly intravascular, even when the tumor cells are small. A timely diagnosis of this entity can be critical. Hence, awareness of a small cell variant of IVLBCL should be increased.
Description of Ventricular Arrhythmia after Taking Herbal Medicines in Middle-Aged Couples
Authors: Mohammad Ali Zakeri, Vahid Mohammadi, Gholamreza Bazmandegan, Maryam Zakeri
Journal: Case Rep Cardiol (2020)
MeSH terms: Case Reports

Medicinal herbs and some derivatives have been used in the treatment of heart disease which is rarely responsible for ventricular arrhythmias and cardiac arrest. Ventricular tachycardia (VT) increases the risk of sudden cardiac death (SCD). However, only a few reports are available about the cardiac ventricular arrhythmia followed by taking herbal medicines. We present two patients (a couple) without a history of heart disease who referred to the hospital with ventricular arrhythmia.
Synostosis of the proximal tibiofibular joint
Authors: Nikolaos K Sferopoulos
Journal: Case Rep Med (2010)
MeSH terms: Case Reports

The incidence of synostosis of the proximal tibiofibular joint (TFJ) was assessed among 1029 patients examined for osteoarthritis of the knee in a 4-year period. Radiographic evidence of a synostosis of the proximal TFJ was demonstrated in 3 knees (3 patients). The synostosis appeared incidental and was not the cause of symptoms in any of them. These patients were further examined with MRI and/or CT scans. In two cases, which were found to be primary (idiopathic), the synostosis was complete and bony. In a third case the lesion was secondary (acquired) to surgical reconstruction for a depressed fracture of the lateral tibial plateau. This iatrogenic complication followed open reduction, internal fixation, and grafting with synthetic bone. The bridging of the joint on the CT views was partial and compatible with ectopic calcification rather than ossification. The patients were treated conservatively and were followed for an average period of 3 years. No evidence that the synostosis accelerated the onset or progression of the degenerative changes to the ipsilateral knee could be verified.
Isolated Superior Mesenteric Vein Tumor Thrombus in a Patient with Gastric Cancer
Authors: Barış Özcan, Metin Çevener, Ayşegül Kargı, Mustafa Özdoğan, Alihan Gürkan
Journal: Case Rep Surg (2018)
MeSH terms: Case Reports

Tumor thrombus in the portal vein can rarely originate from gastric cancer via hematogenous spread, with only few case reports published in the literature. Isolated superior mesenteric vein tumor thrombus in gastric cancer has not been previously reported. A 61-year-old male patient who had undergone distal gastrectomy and gastroenterostomy for gastric ulcer 20 years ago was diagnosed with an obstructive tumor originating from the gastroenterostomy anastomosis site on upper gastrointestinal endoscopy that was performed for complaints of fatigue, oral feeding problems, and anemia. The PET-CT imaging revealed a hypermetabolic mass in the gastroenterostomy region along with hypermetabolic suspected tumor thrombus in the superior mesenteric vein (SMV). A suspected tumor thrombus with contrast enhancement that completely obstructed the SMV was detected on triphasic abdominal computed tomography. Decision for surgery was made due to gastric tumor obstruction. Firstly, lesions suspected with tumor thrombus were extirpated from the SMV and sent to frozen section. Then, it was completely recanalized. A locally advanced tumor originating from the gastroenterostomy anastomosis site that totally obliterated the lumen was observed on surgical exploration. After proving tumor thrombus by frozen, near-total gastrectomy was performed for palliative purposes. Histopathologic examination of the specimen showed gastric invasive adenocarcinoma and tumor thrombi in the SMV (T4N2M1). The patient received adjuvant chemotherapy, and he is at his 22nd-month follow-up with extensive hepatic metastases and intra-abdominal disease. It should be kept in mind that gastric cancer may lead to portal vein tumor thrombus or that it may rarely be associated with an isolated SMV tumor thrombus, both of which are associated with poor prognosis.
Entrapment of a dormia basket in the cystic duct: case report
Authors: Dario Pariani, Giorgio Zetti, Ferdinando Cortese
Journal: Case Rep Surg (2012)

Nowadays endoscopic treatment of common bile duct stones is considered the treatment of choice for all common bile duct stones. Although this procedure is related to a good success rate, in rare cases serious complications can happen, especially if you use a Dormia basket. Here we describe the clinical case of a patient affected by hepatolithiasis, cholelithiasis, and common bile duct lithiasis with entrapment of a Dormia basket in the cystic duct. It was necessary to perform a surgical choledochotomy to deal with this rare complication.
Clinical Presentations of Chagas Cardiomyopathy
Authors: Malik Shehadeh, Ana Barac, Rachel Marcus
Journal: Case Rep Cardiol (2020)
MeSH terms: Case Reports

Chronic Chagas cardiomyopathy (CCC) is the most common cause of nonischemic cardiomyopathy in endemic Latin American countries. Immigrants to the United States suffer from this disease, but it is underrecognized. We describe the three hallmark clinical presentations: stroke, ventricular arrhythmias, and heart failure, which should prompt suspicion for CCC.
Behavioral and neuropsychological profile of a male patient with mosaic PCDH19 mutation
Authors: Margret Johannessen, Ida Marie Kjellsen, Eva Malt
Journal: Epilepsy Behav Rep (2022)
Keywords: epilepsy, executive functioning, mosaic male, neuropsychological assessment, pcdh19
MeSH terms: Case Reports

Mutations in the protocadherin 19 gene (PCDH19) are associated with a female-restricted form of epilepsy. As the disorder has an X-reversed inheritance pattern, men are usually healthy carriers. PCDH19 epilepsy among men due to mosaicism is rare but probably underdiagnosed. We describe the longitudinal development of the behavioral and neuropsychological profile of a male with a mosaic PCDH19 mutation based on assessments carried out at 9, 11, 15, and 19 years of age. He was diagnosed with mild intellectual disability and autism spectrum disorder and had marked deficits in so-called hot executive functions related to emotion, as opposed to purely cognitive aspects of executive functions, the so-called cold executive functions. Although his epilepsy improved and cognition remained stable, executive dysfunction and behavioral problems became the prominent clinical features with age.
Brachial Plexus Chemical Neurolysis with Ethanol for Cancer Pain
Authors: Tuan-Hsing Loh, Samir Patel, Anish Mirchandani, Maxim Eckmann
Journal: Case Rep Med (2018)
MeSH terms: Case Reports

Chemical neurolytic nerve blocks have been successfully used to treat a variety of cancer-related pain. However, the literature has been sparse regarding neurolysis of the brachial plexus for cancer pain. We present a unique case report of a successful chemical neurolysis of the brachial plexus with dehydrated ethanol for a patient suffering from metastatic mammary carcinoma with tumor invasion of the right brachial plexus.
Percutaneous Emergency Needle Caecostomy for Prevention of Caecal Perforation
Authors: Alexandra M Limmer, Zackariah Clement
Journal: Case Rep Surg (2017)
MeSH terms: Case Reports

Caecal perforation is a life-threatening complication of large bowel obstruction with a reported mortality of 34% to 72%. This case describes the novel use of percutaneous needle caecostomy as a life-saving measure to prevent imminent caecal perforation in a 68-year-old lady with large bowel obstruction secondary to an incarcerated incisional hernia. After careful review of computed tomography images and measurement of distances from the abdominal wall to the caecum, the patient's caecum was decompressed in the emergency department using a needle under local anaesthetic. The patient subsequently underwent laparoscopic hernia repair and had an uncomplicated recovery. When conducted safely and with precision in an appropriate patient, percutaneous needle caecostomy can provide immediate symptom relief, reduce risk of caecal perforation, and allow a laparoscopic surgical approach.
Case report: Intraductal tubulopapillary neoplasm of the pancreas with unique clear cell phenotype
Authors: Maria Gabriele Ahls, Marco Niedergethmann, Dietmar Dinter, Christian Sauer, Jutta Lüttges, Stefan Post, Alexander Marx, Timo Gaiser
Journal: Diagn Pathol (2014)
MeSH terms: Carcinoma, Pancreatic Ductal / pathology, Carcinoma, Papillary / pathology, Pancreatic Neoplasms / pathology, Case Reports, Adult, Biomarkers, Tumor / analysis, Carcinoma, Pancreatic Ductal / metabolism, Carcinoma, Papillary / metabolism, Female, Humans, Immunohistochemistry, Pancreatic Neoplasms / metabolism, Phenotype, Biomarkers, Tumor

Intraductal tubulopapillary neoplasms of the pancreas are very rare tumors characterized by intraductal tubulopapillary growth, ductal differentiation, scant intracellular mucin production and cellular dysplasia. Here, we report the first case of an intraductal tubulopapillary neoplasm of the pancreas with clear cell morphology. The tumor was detected during the diagnostic work-up of acute pancreatitis in a 43- year old female. Histological examination revealed a tumor with the typical architecture of an intraductal tubulopapillary neoplasm of the pancreas with tumor cells showing abundant clear cytoplasm and Di-PAS negativity. Immunohistochemistry revealed positivity for Pan-CK, CK7, CK8/18, MUC1, MUC6, carbonic anhydrase IX, CD10, EMA, β-catenin and e-cadherin. Sanger sequencing did not detect mutations for β-catenin, BRAF, KRAS, PIK3CA and GNAS. Altogether, histology, immunohistochemical expression profile (MUC1+, MUC6+, MUC2-, MUC5AC-, thrypsin-, chymotrypsin-, CDX2-) and sequencing results led to the diagnosis of intraductal tubulopapillary neoplasm. However, the neoplasm consisted of cells showing abundant clear cytoplasm, a morphological pattern not being described so far in the current classification of pancreatic intraductal neoplasms. Potential differential diagnosis and the molecular basis of clear cell morphology are discussed. In conclusion, we consider this tumor as intraductal tubulopapillary neoplasm of the pancreas with unique clear cell phenotype. After surgery and without adjuvant therapy, the patient's clinical course has been uneventful for over two years now.
Virtual slides:
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1051828790117127.
Common Variable Immunodeficiency with Genetic Defects Identified by Whole Exome Sequencing
Authors: Ran Li, Yali Zheng, Yuqian Li, Rongbao Zhang, Fang Wang, Donghong Yang, Yanliang Ma, Xinlin Mu, Zhaolong Cao, Zhancheng Gao
Journal: Biomed Res Int (2018)
MeSH terms: Adaptor Proteins, Signal Transducing / genetics, Common Variable Immunodeficiency / genetics, Exome, High-Throughput Nucleotide Sequencing, Mutation, NF-kappa B p50 Subunit / genetics, Case Reports, Adult, Female, Heterozygote, Humans, Middle Aged, Adaptor Proteins, Signal Transducing, NF-kappa B p50 Subunit, NFKB1 protein, human, LRBA protein, human

Common variable immunodeficiency (CVID) belongs to the primary immunodeficiency disorders (PIDs), presenting a profound heterogeneity in phenotype and genotype, with monogenic or complex causes. Recurrent respiratory infections are the most common clinical manifestations. CVID patients can also develop various autoimmune and lymphoproliferative complications. Genetic testing such as whole exome sequencing (WES) can be utilized to investigate likely genetic defects, helping for better clinical management. We described the clinical phenotypes of three sporadic cases of CVID, who developed recurrent respiratory infections with different autoimmune and lymphoproliferative complications. WES was applied to screen disease-causing or disease-associated mutations. Two patients were identified to have monogenic disorders, with compound heterozygous mutations in LRBA for one patient and a frameshift insertion in NFKB1 for another. The third patient was identified to be a complex form of CVID. Two novel mutations were identified, respectively, in LRBA and NFKB1. A combination of clinical and genetic diagnosis can be more extensively utilized in the clinical practice due to the complexity and heterogeneity of CVID.