OpenMed/multicare-articles huggingface dataset:
Granulomatous Lobular Mastitis Associated with Mycobacterium abscessus in South China: A Case Report and Review of the Literature
Authors: Ye-Sheng Wang, Qi-Wei Li, Lin Zhou, Run-Feng Guan, Xiang-Ming Zhou, Ji-Hong Wu, Nan-Yan Rao, Shuang Zhu
Journal: Case Rep Infect Dis (2017)
MeSH terms: Case Reports

Mycobacteria, which are known as rapidly growing bacteria, are pathogens that are responsible for cutaneous or subcutaneous infections that especially occur after injection, trauma, or surgery. In this report, we describe a species of Mycobacterium abscessus that was isolated from a breast abscess in a patient who was previously diagnosed with granulomatous lobular mastitis (GLM). This current case is the first ever presented case of GLM associated with M. abscessus documented in South China. The case presentation highlights the role of M. abscessus in GLM. The association of M. abscessus and GLM is discussed and a summary of breast infection due to Mycobacteria is given.
Warthin tumor-like papillary thyroid carcinoma with a minor dedifferentiated component: report of a case with clinicopathologic considerations
Authors: Paolo Amico, Salvatore Lanzafame, Giovanni Li Destri, Paolo Greco, Rosario Caltabiano, Giada Maria Vecchio, Gaetano Magro
Journal: Case Rep Med (2010)
MeSH terms: Case Reports

Warthin tumor-like papillary thyroid carcinoma is an uncommon variant of papillary thyroid carcinoma. We report a rare case of Warthin tumor-like variant of papillary thyroid carcinoma with a dedifferentiated component consisting of a solid tumor area composed of neoplastic cells with a spindle to tall cell morphology associated with marked nuclear pleomorphism, atypical mitoses, and foci of necrosis. Although our patient presented with a locally aggressive disease (T3 N1b Mo), she is disease-free without radioiodine therapy after a 23-month follow-up period. We emphasize that Warthin tumor-like papillary thyroid carcinoma, like other morphological variants of papillary carcinoma, may occasionally undergo dedifferentiation. As this component may be only focally detectable, we suggest an extensive sampling of all large-sized (>3 cm) papillary thyroid carcinoma. Recognition of any dedifferentiated component in a Warthin tumor-like papillary thyroid carcinoma should be reported, including its percentage, because it may reflect a more aggressive clinical course.
Topographical Choroidal Thickness Change Following PDT for CSC: An OCT Case Report
Authors: William J Wirostko, Rick N Nordgren, Adam M Dubis
Journal: J Ophthalmol (2012)
MeSH terms: Case Reports

Purpose. To describe topographical changes in choroidal thickness as measured by optical coherence tomography following photodynamic therapy (PDT) for central serous chorioretinopathy (CSC). Methods. Case report. Results. By 1 month following PDT, mean (SD) choroidal thickness decreased from 562 microns (24) to 424 microns (27) (P < 0.01) at 3 mm temporal to fovea, 483 microns (9) to 341 microns (21) (P < 0.01) at 1.5 mm temporal to fovea, 576 microns (52) to 370 microns (81) (P < 0.01) under the fovea, 442 microns (30) to 331 microns (54) (P < 0.04) at 1.5 mm nasal to fovea, and 274 microns (39) to 171 microns (17) (P < 0.01) at 3 mm nasal to fovea. The Location of greatest choroidal thickness (648 microns) prior to treatment was at point of leakage on fluorescein angiogram (FA). This region decreased to 504 microns following treatment. Conclusion. A decrease in choroidal thickness can be seen following PDT for CSC as far as 3 mm temporal and 3 mm nasal to fovea. The Location of greatest choroidal thickness may be at point of leakage on FA.
Surgical treatment of femoral medial condyle fracture with lag screws and proximal tibial plate: A case report
Authors: Hiroyasu Kodama, Isaku Saku, Shin Tomoyama
Journal: Int J Surg Case Rep (2020)
Keywords: case report, femoral medial condyle fracture, knee, proximal tibial plate, surgery
MeSH terms: Case Reports

Introduction:
Femoral medial condyle fracture is a rare fracture. Here, we report a case of femoral medial condyle fracture treated with lag screws and proximal tibial plate as a buttress plate.
Case presentation:
A 80-year-old woman fell down 15 steps at her home and reported to our hospital with severe right knee pain. Radiographs and computed tomography demonstrated a femoral medial condyle fracture in the right knee (AO classification: 33-B2). Two days after injury, we performed open reduction and internal fixation using locking compression plate for proximal tibia and screws. The patient had an uneventful postoperative recovery. At the latest follow-up, the patient achieved a range of motion of 0° to 120° and could walk without pain.
Discussion:
Femoral medial condyle fracture is a rare fracture. As with any articular injury, anatomical restoration of the joint surface must be obtained, then lag screw fixation is required. In fractures with a vertical fracture line, a buttress plate is necessary to counteract the vertical shear forces. Nevertheless, there are no available anatomical plates that fit either the femoral medial condyle or fracture fixation, except for the relatively short plate developed for distal femoral osteotomy. We used a locking compression plate - proximal tibial plate 4.5/5.0 (Depuy Synthes TRAUMA) as a buttress plate. The implant fitted well and enhanced joint stability. Postoperative radiographs confirmed anatomical reduction, and the patient achieved a good result.
Conclusion:
The locking compression plate for proximal tibia is an acceptable solution for femoral medial condyle fracture.
A Rare and Potentially Catastrophic Infection: Primary Intestinal Aspergillosis-Case Report in an HIV Patient
Authors: Cátia Dias, Filipa Duarte-Ribeiro, Sara Pipa, Margarida Mota
Journal: Case Rep Infect Dis (2018)
MeSH terms: Case Reports

Aspergillus species are ubiquitous in nature; however, infection is uncommon, except in immunocompromised or immunosuppressed hosts. We present the case of a 71-year-old woman with a history of human immunodeficiency virus infection who presented with fever, weight loss, and diarrhea, posteriorly diagnosed with intestinal aspergillosis after examination of a segmental enterectomy piece. The diagnosis was made postmortem once the patient died after fast and progressive deterioration in the postoperative period.
Late solitary pancreatic metastasis from renal cell carcinoma: a case report
Authors: Anastasios Katsourakis, George Noussios, Iosif Hadjis, Michael Alatsakis, Efthimios Chatzitheoklitos
Journal: Case Rep Med (2012)

We report a case of a 70-year-old man with renal cell carcinoma and metastasis to the pancreas. Symptomatic patients usually present with obstructive jaundice, abdominal pain, or GI bleeding. The diagnosis usually occurs in asymptomatic patients during followup for renal cell carcinoma. It usually befalls slowly from 2 to 18 years after the onset of the primary tumor of the kidney. A 70-year-old man presented in our department with weight loss, anorexia, and elevated blood glucose, having a large tumor on the head of the pancreas treated successfully by pancreatoduodenectomy. Three years after his treatment, the patient is doing well and without recurrence of the tumor. In conclusion, metastasis of renal cell carcinoma to the pancreas is a rare neoplasm accounting for 0.25-3% of all pancreatic tumors.
Idiopathic fourth ventricle outlet obstruction successfully treated by endoscopic third ventriculostomy: a case report
Authors: Yukitomo Ishi, Katsuyuki Asaoka, Hiroyuki Kobayashi, Hiroaki Motegi, Taku Sugiyama, Yuka Yokoyama, Sumire Echizenya, Koji Itamoto
Journal: Springerplus (2015)
Keywords: etv, endoscopic third ventriculostomy, fvoo, fourth ventricle outlet obstruction, hydrocephalus

Introduction:
Fourth ventricle outlet obstruction (FVOO) is a rare cause of obstructive hydrocephalus. We describe a case of idiopathic FVOO that was successfully treated with endoscopic third ventriculostomy (ETV).
Case report:
A 3-year old boy without any remarkable medical history presented with a headache and vomiting. Computed tomography (CT) images, which had incidentally been taken 2 years previously due to a minor head injury, showed no abnormality. Magnetic resonance imaging on admission showed tetra-ventricular hydrocephalus associated with the dilatation of the fourth ventricle outlets, without any obstructive lesions. However, CT ventriculography, involving contrast medium injection through a ventricular catheter, suggested mechanical obstruction of the cerebrospinal fluid (CSF) at the fourth ventricle outlets. Thus, the patient was diagnosed with FVOO and ETV was performed; the hydrocephalus was subsequently resolved. Although hydrocephalus recurred 1 year postoperatively, re-ETV for the highly stenosed fenestration successfully resolved this condition.
Conclusions:
ETV should be considered for FVOO treatment, particularly in idiopathic cases without CSF malabsorption.
Central Retinal Artery Occlusion Associated with Sildenafil Overdose
Authors: Mojtaba Abrishami, Seyedeh Maryam Hosseini, Hamid Mohseni, Majid Razavi, Amir Ghaffarian Mashhadi Nejad, Mohammad Baghi Yazdi, Ghodsieh Zamani
Journal: Case Rep Ophthalmol Med (2021)
MeSH terms: Case Reports

Background:
To report a patient with central retinal artery occlusion (CRAO) associated with sildenafil overdose. Case Presentation. A forty-two-year-old male presented three hours after sudden painless visual loss in the right eye. BCVA was counting finger in two meters, and relative afferent pupillary defect was positive. Fundus examination revealed retinal whiteness except in a limited area of papillomacular bundle and cherry red spot. He consumed two 100 mg film-coated sildenafil tablet (Vizarsin, Krka, d.d., Novo mesto, Slovenia) twelve hours apart, and the last one was six hours before visual loss. He was diagnosed with CRAO with cilioretinal artery sparing. Although we did not find any emboli, anterior chamber paracentesis was done. Four weeks later, BCVA improved to 20/80, with resolving of retinal edema. Cardiovascular, carotid arteries, and neurologic evaluations were negative for any predisposing factor.
Conclusion:
CRAO is a vision threatening condition that might be associated with the overdose of sildenafil.
Metaplastic Carcinoma of the Breast with Squamous Differentiation: A Case Report from the University Teaching Hospital of Kigali (CHUK), Rwanda
Authors: Delphine Uwamariya, Carine Nyampinga, Anne Yvette Nsenguwera, Belson Rugwizangoga
Journal: Case Rep Pathol (2020)
MeSH terms: Case Reports

Metaplastic breast carcinoma is a rare and aggressive condition, accounting less than 1% of breast malignancies. It presents with large mass and frequently with distant metastasis at time of diagnosis. Morphologically, it is characterized by the differentiation of neoplastic epithelium into epithelial or mesenchymal-looking elements like squamous cells, spindle cells, cartilage, or bone and has poor prognosis with its triple negative status.
What about the treatment of asymptomatic forms of congenital malaria: case report and review of the literature
Authors: Salahiddine Saghir, Mounir Moukit, Jaouad Kouach, Naoufal Assoufi, Rachid Abilkassem, Aomar Agadr
Journal: Pan Afr Med J (2020)
Keywords: congenital malaria, plasmodium falciparum, chloroquine, malaria infestation, parasitemia
MeSH terms: Malaria, Falciparum / congenital, Plasmodium falciparum / isolation & purification, Pregnancy Complications, Parasitic / diagnosis, Case Reports, Review, Adult, Female, Humans, Infant, Newborn, Malaria, Falciparum / diagnosis, Male, Pregnancy, Pregnancy Complications, Parasitic / parasitology

We report in this manuscript a case of newborn baby with asymptomatic form of congenital malaria; the screening of the peripheral blood smear of the baby after a positive result in the mother allowed the diagnosis. The authors were permitted through this case to discuss the therapeutic possibility in these cases.
Spontaneous closure of a fully developed macular hole in a severely myopic eye
Authors: C Bruè, I Rossiello, J M Guidotti, C Mariotti
Journal: Case Rep Ophthalmol Med (2014)

Purpose. Myopic macular holes can be difficult to close with surgery and are frequently associated with retinal detachment. We report on a case of a macular hole in a severely myopic eye that underwent spontaneous closure. Methods. An observational case study. Results. A 55-year-old female was referred to Ophthalmology for a central scotoma and metamorphopsia in the right eye. Visual acuity was 1/20 in both eyes. Fundus examination showed loss of the foveal depression, with a small yellow ring in the center of the fovea in the right eye, and a tilted optic disc and peripapillary staphyloma bilaterally. Spectral domain optical coherence tomography (SD-OCT) revealed a fully developed macular hole with a rim of thickened and slightly elevated retina in the right eye. The patient refused surgery. After 4 years of follow-up, her visual acuity improved to 20/40 in the right eye, and SD-OCT revealed spontaneous sealing of the macular hole without bare retinal pigment epithelium. Conclusions. Myopic macular holes represent a challenge regarding their management, and the prognosis is often poor.
Case report: Ultrasound-guided intrauterine biopsy and RF ablation therapy for fetal posterior neck solid tumor: first successful report
Authors: Shanshan Liu, Qiong Luo, Xiaofeng Fu, Minyan Wang, Qingguo Zou, Licheng Wang, Guangjuan Kan, Xing Si, Heqin Dong, Xiani Lan, Yutian Han, Jiang Zhu
Journal: Front Oncol (2022)
Keywords: fetal tumor, head and neck, hemangioma, radiofrequency ablation, ultrasound
MeSH terms: Case Reports

Large fetal head and neck tumors are being increasingly identified during prenatal examination and tend to have a poor prognosis. Nevertheless, appropriate intrauterine interventions at suitable periods can improve pregnancy outcome. Ultrasound-guided puncture biopsy of the solid fetal head and neck mass and radiofrequency ablation of a portion of the tissue can clarify the tumor pathology and reduce the tumor size, respectively. These treatment methods are reproducible and associated with reduced trauma and complications.
Clinical and electrophysiological characteristics of Efavirenz-induced macular toxicity
Authors: Parveen Sen, Sridharan Sudharshan, Aniruddha Banerjee, Abhinav Dhami
Journal: GMS Ophthalmol Cases (2020)
MeSH terms: Case Reports

Efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor, is commonly used to treat HIV-infected individuals. We report a case of painless, progressive and bilateral blurring of vision in an HIV-positive 54-year-old lady within months of treatment with anti-retro viral therapy including Efavirenz. On presentation, her visual acuity was 6/18; N24 and 6/9; N10 in both eyes with mottling of the retinal pigment epithelial at the macula with corresponding scotomas on HVF 30-2 and loss of ellipsoid layer on spectral domain optical coherence topography (OCT). Though full field ERG was normal, multifocal ERG revealed reduced foveal and parafoveal amplitudes. Our case emphasizes the need of periodic ocular examination of these patients on long-term EFV.
Case Report: Hypoglycemia Due to Metastatic Insulinoma in Insulin-Dependent Type 2 Diabetes Successfully Treated With 177 Lu-DOTATATE
Authors: Shejil Kumar, Mariah Melek, Peter Rohl
Journal: Front Endocrinol (Lausanne) (2022)
Keywords: diabetes, hypoglycemia, insulinoma, lutate, lutetium, neuroendocrine tumor, type 2 diabetes
MeSH terms: Diabetes Mellitus, Type 2 / complications, Diabetes Mellitus, Type 2 / drug therapy, Hypoglycemia / etiology, Insulinoma / complications, Insulins, Neuroendocrine Tumors / pathology, Pancreatic Neoplasms / pathology, Case Reports, Review, Aged, 80 and over, Gallium Radioisotopes, Humans, Lutetium, Male, Positron Emission Tomography Computed Tomography, Positron-Emission Tomography, Radionuclide Imaging, Radiopharmaceuticals / therapeutic use, Gallium Radioisotopes, Insulins, Radiopharmaceuticals, copper dotatate CU-64, Lutetium

We describe a 96-year-old man with insulin-dependent type 2 diabetes mellitus who, despite insulin cessation, presented with recurrent hypoglycemia associated with confirmed inappropriate endogenous hyperinsulinemia. 68Ga-DOTATATE-PET/CT scans demonstrated increased uptake in the pancreatic tail with multiple large intensely active liver metastases. Liver biopsy confirmed the diagnosis of well-differentiated metastatic neuroendocrine tumor. He was unsuitable for surgical resection and long-acting somatostatin analog therapy was ineffective. Subsequent management with four cycles of Lutate [177-Lutetium-DOTA0-Tyr3-octreotate (177Lu-DOTATATE)] resulted in resolution of hypoglycemia and ongoing clinical, biochemical, and radiological response 6 years after. This case is unique due to not only the paradoxical entity of insulinoma in insulin-dependent diabetes but also the positive sustained outcome after 177Lu-DOTATATE, given that unresectable metastatic insulinoma carries a poor prognosis. We review published cases of metastatic insulinoma in patients with diabetes mellitus as well as the literature to-date investigating efficacy and safety of Lutate therapy in metastatic insulinoma.
An unusual case of tracheo-pleural fistula and cardiac metastases in oropharyngeal carcinoma: a case report and review of the literature
Authors: Daris Ferrari, Carla Codecà, Giulia Viale, Barbara Bocci, Francesca Broggio, Francesca Crepaldi, Martina Violati, Andrea Luciani, Dario Bauer, Laura Moneghini, Gaetano Bulfamante, Paolo Foa
Journal: Cancers Head Neck (2016)
Keywords: cardiac metastases, chemoradiotherapy, oropharyngeal carcinoma, risk factors, tracheo-pleural fistula
MeSH terms: Case Reports

Background:
Oropharyngeal cancer is frequently associated with human papilloma virus, that also represents a strong prognostic factor. Local relaps and treatment-related complications are frequent, whereas distant metastases occur in about 25% of patients.
Case presentation:
A 49 years-old male presented with a loco-regionally advanced oropharyngeal squamous cell carcinoma and was treated with concomitant chemoradiation. A complete clinical and pathological response was achieved, but the occurrence of necrotising tracheo-esophagitis, with tracheo-mediastino-pleural fistula formation, further complicated the subsequent clinical course. The patient died suddenly. Autopsy revealed multiple myocardial and epicardial metastases from oropharyngeal squamous cell carcinoma.
Conclusions:
Even in case of a transient complete local response, the potential occurrence of severe complications and distant metastases, although infrequent, should be considered. Cardiac metastases are frequently underestimated, as they are often asymptomatic, but may lead to sudden death. Further efforts are needed to improve diagnosis and therapy in this setting.
Clinical and Ultrasound Biomicroscopic Characteristics of Congenital Fibrovascular Pupillary Membrane-Induced Secondary Glaucoma
Authors: Yingting Zhu, Lei Fang, Yimin Zhong, Julius Oatts, Ying Han, Shufen Lin, Liming Chen, Xiaodi Zhou, Yihua Su, Pingping Liu, Xing Liu
Journal: Front Med (Lausanne) (2021)
Keywords: classification, clinical characteristics, congenital fibrovascular pupillary membrane, secondary glaucoma, ultrasound biomicroscopy

Purpose: The purpose of this study was to describe and summarize the clinical features of congenital fibrovascular pupillary membrane-induced secondary glaucoma (CFPMSG). Design: Cross-sectional case series. Methods: Eyes of 32 patients with CFPMSG were enrolled. Demographic data, including gender, laterality, age at presentation, and age at onset of glaucoma were collected. Patients underwent comprehensive ophthalmic examinations and ultrasound biomicroscopy (UBM). CFPMSG eyes were classified into three groups based on UBM findings and intergroup analysis was performed using ANOVA. Results: The average age at presentation was 2.4 ± 4.6 months (mean ± SD) and at glaucoma onset was 3.8 ± 4.5 months. Compared to normal fellow eyes, all affected eyes had increased intraocular pressure (IOP), axial length, corneal diameter, and central corneal thickness, and decreased anterior chamber depth (ACD) (all P ≤ 0.001). Twenty-two affected eyes (68.8%) had evidence of glaucomatous optic neuropathy. Based on iris configuration on UBM, eyes were classified as 53% type I ("U" shape), 34% type II ("Y" shape), and 13% type III (no anterior chamber). IOP in types II (33.8 ± 5.9 mmHg) and III (35.2 ± 5.9 mmHg) was significantly higher than in type I eyes (26.5 ± 5.1 mmHg). The ACD was shallower in type II compared to type I (P = 0.045). Conclusion: Congenital fibrovascular pupillary membrane-induced secondary glaucoma is characterized by ocular hypertension, corneal enlargement and edema, axial length elongation, and glaucomatous optic neuropathy. Glaucoma in this condition is secondary to pupillary block and angle-closure. UBM provides important information for the diagnosis and classification of CFPMSG. This novel classification system demonstrated varying levels of severity and may guide on management of this disease.
Case Reports: Novel Missense Variants in the Filamin C Actin Binding Domain Cause Variable Phenotypes
Authors: Daniele Velardo, Maria Grazia D'Angelo, Andrea Citterio, Elena Panzeri, Laura Napoli, Claudia Cinnante, Maurizio Moggio, Giacomo Pietro Comi, Dario Ronchi, Maria Teresa Bassi
Journal: Front Neurol (2022)
Keywords: filamin c, actin binding domain, distal myopathy, muscle electron microscopy, muscle magnetic resonance imaging, next generation sequencing
MeSH terms: Case Reports

Filamin C is a large dimeric actin-binding protein, most prevalent in skeletal and cardiac muscle Z-discs, where it participates in sarcomere mechanical stabilization and intracellular signaling, interacting with numerous binding partners. Dominant heterozygous mutations of Filamin C gene cause several forms of myopathy and structural or arrhythmogenic cardiomyopathy. In this report we describe clinical and molecular findings of two Italian patients, in whom we identified two novel missense variants located within the Filamin C actin binding domain. Muscle imaging, histological and ultrastructural findings are also reported. Our results underline the extreme inter- and intrafamilial variability of clinical manifestations, hence the need to extend the investigation also to asymptomatic relatives, and the relevance of a broad diagnostic approach involving muscle electron microscopy, skeletal muscle magnetic resonance imaging and next generation sequencing techniques.
Epileptic Encephalopathy and Cerebellar Atrophy Resulting from Compound Heterozygous CACNA2D2 Variants
Authors: Kameryn M Butler, Philip J Holt, Sarah S Milla, Cristina da Silva, John J Alexander, Andrew Escayg
Journal: Case Rep Genet (2018)
MeSH terms: Case Reports

CACNA2D2 encodes an auxiliary subunit of the voltage-dependent calcium channel. To date, there have only been two reports of individuals with early-infantile epileptic encephalopathy due to CACNA2D2 mutations. In both reports, patients were homozygous for the identified variants. Here, we report a patient with epileptic encephalopathy and cerebellar atrophy who was found to have two novel variants in the CACNA2D2 gene: c.782C>T (p.Pro261Leu) and c.3137T>C (p.Leu1046Pro), by whole-exome sequencing. The variants were shown to be inherited in trans and the unaffected parents were confirmed to be heterozygous carriers. This is the third report of recessive CACNA2D2 variants associated with disease and the first report of compound heterozygous variants. The clinical description of this new case highlights the phenotypic similarities amongst individuals with CACNA2D2-related disease and suggests that CACNA2D2 should be considered as a differential diagnosis in individuals with cerebellar dysfunction and multiple seizure types that begin in the first year of life.