OpenMed/multicare-articles huggingface dataset:
Indolent small intestinal CD4+ T-cell lymphoma is a distinct entity with unique biologic and clinical features
Authors: Elizabeth Margolskee, Vaidehi Jobanputra, Suzanne K Lewis, Bachir Alobeid, Peter H R Green, Govind Bhagat
Journal: PLoS One (2013)
MeSH terms: CD4-Positive T-Lymphocytes / pathology, Intestine, Small / pathology, Lymphoma, T-Cell, Peripheral / pathology, Case Reports, Adult, Antigens, CD / genetics, Antigens, CD / immunology, CD4-Positive T-Lymphocytes / immunology, CD4-Positive T-Lymphocytes / metabolism, Celiac Disease / diagnosis, Celiac Disease / immunology, Celiac Disease / metabolism, Celiac Disease / pathology, Diagnosis, Differential, Diarrhea / pathology, Female, Gene Expression / immunology, Gene Expression Profiling, Humans, Immunophenotyping, Intestine, Small / immunology, Intestine, Small / metabolism, Lymphoma, T-Cell, Peripheral / diagnosis, Lymphoma, T-Cell, Peripheral / immunology, Lymphoma, T-Cell, Peripheral / metabolism, Male, Middle Aged, Polymorphism, Single Nucleotide, Receptors, Antigen, T-Cell / genetics, Receptors, Antigen, T-Cell / immunology, Weight Loss, Antigens, CD, Receptors, Antigen, T-Cell

Enteropathy-associated T-cell lymphomas (EATL) are rare and generally aggressive types of peripheral T-cell lymphomas. Rare cases of primary, small intestinal CD4+ T-cell lymphomas with indolent behavior have been described, but are not well characterized. We describe morphologic, phenotypic, genomic and clinical features of 3 cases of indolent primary small intestinal CD4+ T-cell lymphomas. All patients presented with diarrhea and weight loss and were diagnosed with celiac disease refractory to a gluten free diet at referring institutions. Small intestinal biopsies showed crypt hyperplasia, villous atrophy and a dense lamina propria infiltrate of small-sized CD4+ T-cells often with CD7 downregulation or loss. Gastric and colonic involvement was also detected (n = 2 each). Persistent, clonal TCRβ gene rearrangement products were detected at multiple sites. SNP array analysis showed relative genomic stability, early in disease course, and non-recurrent genetic abnormalities, but complex changes were seen at disease transformation (n = 1). Two patients are alive with persistent disease (4.6 and 2.5 years post-diagnosis), despite immunomodulatory therapy; one died due to bowel perforation related to large cell transformation 11 years post-diagnosis. Unique pathobiologic features warrant designation of indolent small intestinal CD4+ T-cell lymphoma as a distinct entity, greater awareness of which would avoid misdiagnosis as EATL or an inflammatory disorder, especially celiac disease.
Intramuscular Cavernous Hemangioma of Medial Rectus Muscle in Paediatric Age Group
Authors: Anuj Mehta, Shalini Butola, Mayuresh Naik, Sangeeta Abrol, Anju Kumari
Journal: Case Rep Ophthalmol Med (2017)
MeSH terms: Case Reports

An 11-year-old male child presented with a mass on the nasal aspect of the right eye that has been there for the last 2 years. Extraocular movements were decreased in the right eye on levoversion, levoelevation, and levodepression. Local examination revealed a bluish mass with irregular surface and ill-defined margins located in the medial rectus muscle. The mass was 10 × 20 mm in size, firm, nodular, nontender, nonpulsatile, noncompressible, and nonreducible. MRI of the orbit revealed a well-defined mass of approximately 23 × 13 mm along the medial rectus (MR) muscle. It was hyperintense on T2W images with very minimal contrast enhancement. A provisional diagnosis of hemangioma or lymphangioma with intralesional haemorrhage was made. During surgical excision, the mass was found to be encapsulated by MR fibres. The MR fibres were separated, and the mass measuring 20 × 8 × 6.5 mm was removed and sent for histopathology. The histopathological examination revealed an intramuscular cavernous hemangioma.
Radio Frequency Ablation in Drug Resistant Chemotherapy-induced Peripheral Neuropathy: A Case Report and Review of Literature
Authors: Naveen Yadav, Frenny Ann Philip, Vikas Gogia, Prakash Choudhary, Shiv Pratap Sing Rana, Seema Mishra, Sushma Bhatnagar
Journal: Indian J Palliat Care (2010)
Keywords: chemotherapy-induced neuropathy, median nerve, pulse radiofrequency, ulnar nerve
MeSH terms: Case Reports

Chemotherapy-induced peripheral neuropathy (CIPN) is a frequently encountered complication. It can result from a host of agents. Various modalities of treatment have been advocated, of which a novel method is radio frequency ablation. A 63-year-old male, a case of carcinoma prostrate with bone metastases, presented with tingling and numbness in right upper limb. He was given morphine, gabapentin and later switched to pregabalin, but medications provided only minor relief. Initially he was given stellate ganglion block, then radiofrequency ablation of dorsal root ganglion was done, but it failed to provide complete relief. Pulsed radiofrequency ablation (PRF) was then done for 90 seconds; two cycles each in both ulnar and median nerve. After the procedure the patient showed improvement in symptoms within four to five hours and 80% relief in symptoms. We conclude that PRF can be used for the treatment of drug resistant CIPN.
Management of a young female patient with Fournier's gangrene and Lemierre's syndrome
Authors: Theodoros Aslanidis, Athena Myrou, Maria Giannakou-Peftoulidou
Journal: Pan Afr Med J (2014)
Keywords: fournier's gangrene, lemierre's syndrome
MeSH terms: Anti-Bacterial Agents / therapeutic use, Antifungal Agents / therapeutic use, Candidiasis / drug therapy, Fournier Gangrene / drug therapy, Klebsiella Infections / drug therapy, Lemierre Syndrome / drug therapy, Staphylococcal Infections / drug therapy, Case Reports, Acetamides / therapeutic use, Candida albicans / isolation & purification, Candidiasis / complications, Candidiasis / microbiology, Caspofungin, Debridement, Drug Therapy, Combination, Echinocandins / therapeutic use, Female, Fournier Gangrene / complications, Fournier Gangrene / microbiology, Humans, Klebsiella Infections / complications, Klebsiella Infections / microbiology, Klebsiella pneumoniae / isolation & purification, Lemierre Syndrome / complications, Lemierre Syndrome / microbiology, Linezolid, Lipopeptides, Oxazolidinones / therapeutic use, Staphylococcal Infections / complications, Staphylococcal Infections / microbiology, Staphylococcus epidermidis / isolation & purification, Young Adult, Acetamides, Anti-Bacterial Agents, Antifungal Agents, Echinocandins, Lipopeptides, Oxazolidinones, Caspofungin, Linezolid

Fournier's gangrene is an acute, rapidly progressive, and potentially fatal, infective necrotizing fasciitis affecting the external genitalia, perineal or perianal regions. Lemierre's syndrome is a condition characterized by thrombophlebitis of the internal jugular vein and bacteremia caused by primarily anaerobic organisms, following a recent oropharyngeal infection. Although the literature about either of them is rich, there is no report about co-appearance of the two syndromes. We present the case of a young healthy female patient who suffered concomitantly from Fournier's gangrene and Lemierre's syndrome after minor surgery.
Patterns of preserved and impaired spatial memory in a case of developmental amnesia
Authors: R Shayna Rosenbaum, Benjamin N Cassidy, Katherine A Herdman
Journal: Front Hum Neurosci (2015)
Keywords: case study, developmental amnesia, extended hippocampal system, hippocampus, landmark recognition, mental navigation, spatial learning

The hippocampus is believed to have evolved to support allocentric spatial representations of environments as well as the details of personal episodes that occur within them, whereas other brain structures are believed to support complementary egocentric spatial representations. Studies of patients with adult-onset lesions lend support to these distinctions for newly encountered places but suggest that with time and/or experience, schematic aspects of environments can exist independent of the hippocampus. Less clear is the quality of spatial memories acquired in individuals with impaired episodic memory in the context of a hippocampal system that did not develop normally. Here we describe a detailed investigation of the integrity of spatial representations of environments navigated repeatedly over many years in the rare case of H.C., a person with congenital absence of the mammillary bodies and abnormal hippocampal and fornix development. H.C. and controls who had extensive experience navigating the residential and downtown areas known to H.C. were tested on mental navigation tasks that assess the identity, location, and spatial relations among landmarks, and the ability to represent routes. H.C. was able to represent distances and directions between familiar landmarks and provide accurate, though inefficient, route descriptions. However, difficulties producing detailed spatial features on maps and accurately ordering more than two landmarks that are in close proximity to one another along a route suggest a spatial representation that includes only coarse, schematic information that lacks coherence and that cannot be used flexibly. This pattern of performance is considered in the context of other areas of preservation and impairment exhibited by H.C. and suggests that the allocentric-egocentric dichotomy with respect to hippocampal and extended hippocampal system function may need to be reconsidered.
Sarcomatoid Carcinoma of the Oral Cavity: A Diagnostic Dilemma
Authors: Anshul Mahajan, Sujata Mohanty, Sujoy Ghosh, Aadithya B Urs, Nita Khurana, Sunita Gupta
Journal: Case Rep Dent (2017)
MeSH terms: Case Reports

Sarcomatoid carcinoma (SC) is a rare variant of squamous cell carcinoma which is characterized by a dysplastic epithelial component and a stromal element with invasive fusiform or spindle-shaped cells. The clinical and histopathologic characteristics make it very difficult to distinguish SC from epithelioid sarcoma (ES). We present a case of a 51-year-old man with a soft tissue mass in the oral cavity diagnosed as proximal variant of epithelioid sarcoma on incisional biopsy. A thorough radiologic examination was conducted to rule out the possibility of a primary elsewhere in the body. Supraomohyoid neck dissection, mandibular resection, and reconstruction with recon plates were carried out. Histopathologic examination was suggestive of epithelioid variant of SC which was contrary to the incisional biopsy report. The dilemma in diagnosis was resolved by observing the presence of invading atypical epithelial cells into the stroma confirming the epithelial origin of the tumor.
Case report: Ultrahypofractionated palliative breast radiotherapy for a fungating invasive mammary carcinoma
Authors: Yejun Hong, Nancy Nixon, Jeffrey Q Cao, Sangjune Laurence Lee
Journal: Front Oncol (2023)
Keywords: breast cancer, case report, palliative, radiation complications, radiotherapy, ultrahypofractionated
MeSH terms: Case Reports

Palliative radiotherapy for symptomatic and intact breast tumors must balance convenience, efficacy, and risk of acute toxicity. This case report presents a patient with metastatic breast cancer and an intact fungating primary tumor. She was treated with an ultrahypofractionated radiation therapy, 26 Gy in 5 consecutive daily fractions, with sequential palliative chemotherapy. This resulted in a minimal toxicity profile and significant reduction of tumor burden and symptoms.
A Case of Anti-Jo-1 Myositis with Unique Biopsy Findings
Authors: Beenish Zulfiqar, Pavel Aksionav, Mohamad Bittar, Cathy Chapman
Journal: Case Rep Rheumatol (2022)
MeSH terms: Case Reports

Antisynthetase syndrome (ASS) or anti-Jo-1 antibody syndrome has a classic clinical presentation including arthritis, myositis, interstitial lung disease, mechanic hands, and/or Raynaud's phenomenon. The biopsy findings are distinctive from polymyositis or dermatomyositis. We describe an interesting case of ASS where a patient presented with significant muscle weakness, proteinuria, and interstitial lung disease. She also had positive Ro-52 antibodies in addition to anti-Jo-1 antibodies. Her biopsy findings were consistent with inflammatory necrotizing myositis.
A Severe Diabetic Foot Ulcer With Intermediate Cuneiform Displacement and Multidrug-Resistant Pseudomonas aeruginosa Infection: A Rare Case Report
Authors: Wei Chai, Yuqing Wang, Fengjuan Jiao, Yili Wu, Shuai Wang
Journal: Front Med (Lausanne) (2020)
Keywords: antibiotic selection, debridement, diabetic foot ulcer, intermediate cuneiform displacement, multidrug-resistant infection, wound dressing
MeSH terms: Case Reports

Diabetic foot ulcer (DFU) is considered as one of the most serious and prevailing complications of diabetes mellitus, while it is the major cause of amputations in diabetic patients. Herein, we reported an acquired severe traumatic DFU with an intermediate cuneiform hairline fracture and displacement in a 55-year old male (Grade IV of Wagner classification; Grade III of IWGDF classification). The Pseudomonas aeruginosa was identified in pus culture. Data of antibiotic susceptibility testing indicated that the isolates of Pseudomonas aeruginosa were multi-drug resistant. Routine debridement, clearing displaced intermediate cuneiform and drainage were performed to facilitate the outflow of pus and pressure mitigation. Dressing with Prontosan solution and gel was applied to the wound, and meropenem was systemically administrated in addition to effective glycemic control. The DFU has been fully healed after ~40-day treatment. For this case, clearing the displaced and fractured intermediate cuneiform is essential for the heal of the DFU in addition to the common strategy for DFU treatment, i.e., the combination of debridement, pressure mitigation, wound dressing with Prontosan, antibiotic selection and effective glycemic control. This case report might have value for the treatment of complex DFU with bone fracture and displacement, reducing the risk of amputation.
Primary coenzyme Q10 deficiency-7: expanded phenotypic spectrum and a founder mutation in southern Chinese
Authors: Mullin Ho-Chung Yu, Mandy Ho-Yin Tsang, Sophie Lai, Matthew Sai-Pong Ho, Donald M L Tse, Brooke Willis, Anna Ka-Yee Kwong, Yen-Yin Chou, Shuan-Pei Lin, Catarina M Quinzii, Wuh-Liang Hwu, Yin-Hsiu Chien, Pao-Lin Kuo, Victor Chi-Man Chan, Cheung Tsoi, Shuk-Ching Chong, Richard J T Rodenburg, Jan Smeitink, Christopher Chun-Yu Mak, Kit-San Yeung, Jasmine Lee-Fong Fung, Wendy Lam, Joannie Hui, Ni-Chung Lee, Cheuk-Wing Fung, Brian Hon-Yin Chung
Journal: NPJ Genom Med (2019)
Keywords: disease genetics, diseases
MeSH terms: Case Reports

Primary coenzyme Q10 deficiency-7 (COQ10D7) is a rare mitochondrial disease caused by biallelic mutations in COQ4. Here we report the largest cohort of COQ10D7 to date, with 11 southern Chinese patients confirmed with biallelic COQ4 mutations. Five of them have the classical neonatal-onset encephalo-cardiomyopathy, while the others have infantile onset with more heterogeneous clinical presentations. We also identify a founder mutation COQ4 (NM_016035.5): c.370G>A, p.(Gly124Ser) for COQ10D7, suggesting a higher chance of occurrence in the southern Chinese. This study helps improve understanding of the clinical spectrum of this disorder.
Hypertrophy of the feet and ankles presenting in primary hypertrophic osteoarthropathy or pachydermoperiostosis: a case report
Authors: Rim Akrout, Samar Bendjemaa, Héla Fourati, Mariem Ezzeddine, Imene Hachicha, Soufiene Baklouti
Journal: J Med Case Rep (2012)

Introduction:
Pachydermoperiostosis or primary hypertrophic osteoathropathy is a rare genetic disease with autosomal transmission. This disorder, which affects both bones and skin, is characterized by the association of dermatologic changes (pachydermia or thickening of the skin) and rheumatologic manifestations (periostosis and finger clubbing). Here, we report a new observation of pachydermoperiostosis.
Case presentation:
A 20-year-old North African Tunisian Caucasian man presented with hypertrophic osteoarthropathy. On a clinical examination, we found morphologic abnormalities of his face and extremities associated with skin changes. The laboratory findings were normal. A work-up disclosed no organic etiology. The final diagnosis consisted of pachydermoperiostosis syndrome.
Conclusion:
Pachydermoperiostosis is a rare entity that should be differentiated from secondary hypertrophic osteoarthropathy and chronic rheumatic diseases.
The impact of music-imaginative pain treatment (MIPT) on psychophysical affect regulation - A single case study
Authors: Sina Glomb, Irina Böckelmann, Jörg Frommer, Susanne Metzner
Journal: Front Pain Res (Lausanne) (2022)
Keywords: affect regulation, heart rate variabiity, music-imaginative paint treatment, somatoform pain disorder, trauma
MeSH terms: Case Reports

Music-imaginative Pain Treatment (MIPT) is part of the multi-professional treatment plan for hospitalised patients in departments for psychosomatic medicine. MIPT is an intervention that encourages the patient to create music representing pain and relief from pain and promotes active engagement and self-reflection. This single case study of a 46-year-old female patient diagnosed with chronic pain disorder with somatic and psychological factors includes narrative, demographic, psychometric, and cardiophysiological data. During the interventions, early childhood stress, which is a risk factor for developing chronic pain, turns out to be a crucial focal point in therapy and conspicuous in her handling of the music. Social trauma is considered an appropriate concept for a deeper understanding of the case.
Case report of LCP pediatric hip osteosynthesis of a proximal femoral fracture in a child with marble bone disease
Authors: Hristo Georgiev, Venelin A Alexiev
Journal: Pan Afr Med J (2013)
Keywords: lcp paediatric hip, osteopetrosis, child, open reduction, pathologic intertrochanteric fracture
MeSH terms: Bone Plates, Femoral Fractures / surgery, Osteopetrosis / complications, Case Reports, Adolescent, Bulgaria, Female, Femoral Fractures / etiology, Fracture Fixation, Internal / methods, Humans

We present a case report demonstrating the experience of the department of pediatric orthopaedics of the University Orthopedic Hospital at Sofia Medical University in the treatment of an intertrochanteric proximal femoral fracture in a child with osteopetrosis. We performed open fracture reduction with stable 120° LCP (Locking Compression Plate) Pediatric hip osteosynthesis. Fracture consolidation and ability to walk without crutches was achieved in a half a year. The presented case is the first for Bulgaria. There are still no publications in the world literature on application of such osteosynthesis in marble bone disease.
Posner-Schlossman Syndrome in Common Variable Immunodeficiency
Authors: Madiha Huq, Neha Sanan, Phuong Daniels, Robert Hostoffer
Journal: Case Rep Ophthalmol Med (2020)
MeSH terms: Case Reports

Introduction:
Posner-Schlossman syndrome (PSS) is a rare glaucomatocyclitic crisis with clinical features including recurrent episodes of unilateral elevated intraocular pressure. Autoimmune and infectious causes have been proposed as potential etiologies of PSS. We report the first case of PSS in the setting of common variable immunodeficiency (CVID). Case Report. A sixty-two-year-old Caucasian female with a medical history of CVID and ulcerative colitis presented to the emergency room with complaints of acute right-sided vision changes. She reported image distortion, blurriness, and loss of central vision. Physical exam was significant for mildly injected right conjunctiva, visual acuity of 20/70 in right eye, and 20/25 in left eye. The right intraocular pressure was measured at 34 mmHg and left at 12 mmHg. The gonioscopy and dilated fundus examination were unremarkable. Cup to disc ratio was within normal limits, and no afferent pupillary defects were recorded. The patient was acutely treated with three rounds of dorzolamide/timolol and 0.2% brimonidine which decreased the right eye intraocular pressure to 24 mmHg. On follow-up exam with an ophthalmologist, anterior uveitis including an elevated pressure of 41 mmHg on the right and 18 mmHg on the left eye was noted and a PSS diagnosis was confirmed.
Conclusion:
PSS remains a rare condition with uncertain etiology and no associated systemic conditions. PSS has been postulated to be linked to autoimmune conditions. CVID is associated with many autoimmune disorders including Sjogren's, rheumatoid arthritis, and colitis. There have been a few reported CVID-associated ocular diseases including granulomatous uveitis and conjunctivitis, chronic anterior uveitis, and birdshot retinopathy. We describe the first case of PSS in a patient with CVID.
Mucoid degeneration of the anterior cruciate ligament: a case report
Authors: Khalid Ibn el Kadi, Florian Marcaillou, Stephane Blanc, Bassam Salloum, Cyril Dimontagliari, Fawzi Boutayeb
Journal: Pan Afr Med J (2013)
Keywords: anterior cruciate ligament, magnetic resonance imaging, arthroscopy, mucoid degeneration
MeSH terms: Anterior Cruciate Ligament / pathology, Anterior Cruciate Ligament / surgery, Case Reports, Anterior Cruciate Ligament / physiopathology, Arthralgia / etiology, Arthralgia / surgery, Arthroscopy, Female, Humans, Hypertrophy / pathology, Hypertrophy / physiopathology, Hypertrophy / surgery, Knee Joint / physiopathology, Knee Joint / surgery, Magnetic Resonance Imaging, Middle Aged, Range of Motion, Articular / physiology

We report a case of mucoid degeneration of the anterior cruciate ligament (ACL). Mucoid degeneration of the ACL is a very rare cause of knee pain. There have been only some reported cases of mucoid degeneration of the ACL in the English literature. We reviewed previous reports and summarized clinical features and symptoms, including those found in our case. Magnetic Resonance Imaging is the most useful tool for differentiating mucoid degeneration of the ACL from an intraligamentous ganglion or other lesions in the knee joint. If this disease is considered preoperatively, it can be diagnosed easily based on characteristic findings.
Bilateral Renal Colic as an Initial Presentation of Erdheim-Chester Disease
Authors: Julien Sarkis, Fady Haddad, Sarah Nasr, Elie Hanna, Ahmad Mroueh, Elie Nemr
Journal: Case Rep Urol (2019)
MeSH terms: Case Reports

Erdheim-Chester disease (ECD) is a rare non-Langerhans cells histiocytosis characterized by multiorgan involvement, with renal-ECD documented in over one-third of patients. Renal disease is generally asymptomatic, rarely causing hydronephrosis and kidney impairment. In addition, the diverse clinical picture of Erdheim-Chester disease arises slowly with sequential manifestations. We present a rare case of a 75-year-old woman on long-term treatment for panhypopituitarism and steroid therapy for vasculitis, presenting to the emergency department with bilateral renal colic and acute kidney injury. Abdominopelvic CT scan revealed renal infiltration with signs of retroperitoneal fibrosis and hydronephrosis. Kidney CT-guided biopsy and 18-fluorodeoxyglucose (FDG) positron emission tomography whole body scan as well as the history of hypopituitarism and vasculitis confirmed the diagnosis of Erdheim-Chester disease. Proper therapy with interferon-α was started. This case describes the multifaced manifestation of this disease and the difficulty to establish the diagnosis, as well as the pivotal role that a urologist can play in its management.