OpenMed/multicare-articles huggingface dataset:
Percutaneous Irreversible Electroporation of Unresectable Hilar Cholangiocarcinoma (Klatskin Tumor): A Case Report
Authors: Marleen C A M Melenhorst, Hester J Scheffer, Laurien G P H Vroomen, Geert Kazemier, M Petrousjka van den Tol, Martijn R Meijerink
Journal: Cardiovasc Intervent Radiol (2016)
Keywords: ablation techniques/adverse effects, cholangiocarcinoma/klatskin, electroporation/methods, irreversible electroporation (ire), tumor ablation/percutaneous
MeSH terms: Bile Duct Neoplasms / surgery, Electroporation / methods, Klatskin Tumor / surgery, Case Reports, Ablation Techniques / methods, Aged, Bile Duct Neoplasms / diagnostic imaging, Bile Ducts, Intrahepatic / diagnostic imaging, Bile Ducts, Intrahepatic / surgery, Female, Humans, Klatskin Tumor / diagnostic imaging, Radiography, Interventional / methods, Tomography, X-Ray Computed / methods, Treatment Outcome

Irreversible electroporation (IRE) is a novel image-guided ablation technique that is rapidly gaining popularity in the treatment of malignant tumors located near large vessels or bile ducts. The presence of metal objects in the ablation zone, such as Wallstents, is generally considered a contraindication for IRE, because tissue heating due to power conduction may lead to thermal complications. This report describes a 66-year-old female with a Bismuth-Corlette stage IV unresectable cholangiocarcinoma with a metallic Wallstent in the common bile duct, who was safely treated with percutaneous IRE with no signs for relapse 1 year after the procedure.
Potential envenomation by the aglyphous pseudoxyrhophiine snake Leioheterodon madagascariensis and description of its dentition
Authors: Bertrand Razafimahatratra, Cynthia Wang, Akira Mori, Frank Glaw
Journal: J Venom Anim Toxins Incl Trop Dis (2015)
Keywords: dentition, envenomation, lamprophiidae, leioheterodon madagascariensis, madagascar, microcomputed tomography, pseudoxyrhophiinae
MeSH terms: Case Reports

We report on a case of potential envenomation caused by multiple bites by the aglyphous opisthodont snake Leioheterodon madagascariensis in the left thumb of a healthy adult man, which is among the most serious snakebites hitherto reported from Madagascar. The adult snake (total length > 1 meter) was unusually aggressive before and during capture. The symptoms included extensive bleeding, severe local pain, and substantial swelling of the hand and the distal part of the lower arm. The swelling disappeared entirely after five days, but pain in the thumb (when moved) was recognizable even longer. Although L. madagascariensis is widespread and common in anthropogenic habitats in eastern and western Madagascar, this case report seems to be the first description of long-lasting symptoms of its bite. Since aglyphous snakes are relatively rarely involved in "envenomation" and because hemolytic activity has been recorded in the secretions of the Duvernoy's glands of Leioheterodon, we describe its dentition using microcomputed tomography and discuss the potential mode of envenomation in this case.
Visceral Kaposi's Sarcoma Related to Human Herpesvirus-8 in Liver Transplant Recipient: Case Report and Literature Review
Authors: H Benhammane, G Mentha, E Tschanz, O El Mesbahi, P Y Dietrich
Journal: Case Rep Oncol Med (2012)

Background. Kaposi's sarcoma (KS) in transplant recipients is about 400 to 500 times rate in the general population. It is strongly associated to Human herpesvirus-8 (HHV-8) infection which has been found in 95% of KS lesions. The optimal approach to managing posttransplantation KS is to reduce or discontinue immunosuppressive therapy but this strategy carries a risk of the acute rejection of the graft. Recently, the use of an mTOR inhibitor has added new opportunities for KS treatment and prevention. Case Report. We report a case of 24 years-old Turkish woman with visceral HHV-8-associated Kaposi's sarcoma after orthotopic liver transplantation. Conclusion. Posttransplantation KS is considered an experimental model of virus induced tumor suggesting the usefulness of HHV-8 screening in transplant recipient and donor. Therapeutic approaches are complex and require a multidisciplinary team.
SCN10A Mutation in a Patient with Erythromelalgia Enhances C-Fiber Activity Dependent Slowing
Authors: Andreas M Kist, Dagrun Sagafos, Anthony M Rush, Cristian Neacsu, Esther Eberhardt, Roland Schmidt, Lars Kristian Lunden, Kristin Ørstavik, Luisa Kaluza, Jannis Meents, Zhiping Zhang, Thomas Hedley Carr, Hugh Salter, David Malinowsky, Patrik Wollberg, Johannes Krupp, Inge Petter Kleggetveit, Martin Schmelz, Ellen Jørum, Angelika Lampert, Barbara Namer
Journal: PLoS One (2016)
MeSH terms: Erythromelalgia / genetics, Ganglia, Spinal / metabolism, NAV1.8 Voltage-Gated Sodium Channel / genetics, Pain / genetics, Case Reports, Action Potentials / genetics, Electric Stimulation, Erythromelalgia / physiopathology, Ganglia, Spinal / pathology, Humans, Male, Middle Aged, Mutation, Nerve Fibers, Unmyelinated, Pain / physiopathology, Patch-Clamp Techniques, Sensory Receptor Cells / metabolism, Sensory Receptor Cells / pathology, Tetrodotoxin / genetics, NAV1.8 Voltage-Gated Sodium Channel, SCN10A protein, human, Tetrodotoxin

Gain-of-function mutations in the tetrodotoxin (TTX) sensitive voltage-gated sodium channel (Nav) Nav1.7 have been identified as a key mechanism underlying chronic pain in inherited erythromelalgia. Mutations in TTX resistant channels, such as Nav1.8 or Nav1.9, were recently connected with inherited chronic pain syndromes. Here, we investigated the effects of the p.M650K mutation in Nav1.8 in a 53 year old patient with erythromelalgia by microneurography and patch-clamp techniques. Recordings of the patient's peripheral nerve fibers showed increased activity dependent slowing (ADS) in CMi and less spontaneous firing compared to a control group of erythromelalgia patients without Nav mutations. To evaluate the impact of the p.M650K mutation on neuronal firing and channel gating, we performed current and voltage-clamp recordings on transfected sensory neurons (DRGs) and neuroblastoma cells. The p.M650K mutation shifted steady-state fast inactivation of Nav1.8 to more hyperpolarized potentials and did not significantly alter any other tested gating behaviors. The AP half-width was significantly broader and the stimulated action potential firing rate was reduced for M650K transfected DRGs compared to WT. We discuss the potential link between enhanced steady state fast inactivation, broader action potential width and the potential physiological consequences.
Recurrent dermatofibrosarcoma protuberans: challenging a surgeon's dexterity for the 'tricky' margins
Authors: Deepak Kumar Diwakar, Nikita Wadhwani, Shivani Paruthi
Journal: Ecancermedicalscience (2018)
Keywords: breast tumours, dermatofibrosarcoma protuberans (dfsp), oncosurgery, recurrent skin tumours
MeSH terms: Case Reports

Soft tissue tumours represent 0.2%-1% of all breast malignancies. [Al Tarakji M, Toro A, and Di Carlo I, et al (2015) Unusual presentation of dermatofibrosarcoma protuberans in a male patient's breast: a case report and review of the literatureWorld J Surg Oncol13 158 https://doi.org/10.1186/s12957-015-0562-1]. Out of those, Dermatofibrosarcoma protuberans (DFSP) of the breast is extremely rare, especially in men with only six cases, including this case, reported so far. We report a case of recurrent DFSP in a 35-year-old male after a latency of 8 years in the region of previous surgical scar. It was managed by a wide local excision followed by reconstruction using latissimus dorsi flap. It is important to carefully manage recurrent cases because the post-operative margin status is an important determinant of recurrence, and therefore, requires vigilant resection of the tumour without causing extensive morbidity to the patient.
A sticky situation: a case of Actinomyces viscosus vertebral osteomyelitis
Authors: Stephanie L Grach, Aaron J Tande
Journal: J Bone Jt Infect (2020)
MeSH terms: Case Reports

Actinomyces viscosus is an oral bacterium that is rarely virulent in humans, with most case presentations involving dental and maxillofacial infections. We describe the first reported case of A. viscosus vertebral osteomyelitis in a patient who had a significant response to penicillin after minimal response to cephalosporin therapy.
A Novel Missense Mutation 224G>T (R75M) in SRY Coding Region Interferes with Nuclear Import and Results in 46, XY Complete Gonadal Dysgenesis
Authors: Wufang Fan, Bei Wang, Shanshan He, Tengfei Zhang, Chenxing Yin, Yunping Chen, Shuqi Zheng, Jixia Zhang, Lin Li
Journal: PLoS One (2016)
MeSH terms: Active Transport, Cell Nucleus / genetics, Gonadal Dysgenesis, 46,XY / genetics, Gonadal Dysgenesis, 46,XY / pathology, Mutation, Missense / genetics, Open Reading Frames / genetics, Sex-Determining Region Y Protein / genetics, Case Reports, Adult, Female, Humans, Young Adult, SRY protein, human, Sex-Determining Region Y Protein

SRY-mutation-caused sex reversal is a rare disease and mostly associated with a de novo mutation since the patients with defective SRY is infertile. There are many reports about SRY-mutation associated 46, XY ovarian disorder of sex development (DSD), but few described their molecular mechanism. Here we report a de novo mutation 224G>T (R75M) in SRY associated with a phenotypic female, 46, XY karyotype and dysgerminoma. The wild and mutated SRY were cloned into recombinant plasmid and expressed in cells in vitro, the result showed the mutated SRY is greatly accumulated in cytoplasm while the wild type SRY is mostly localized in nucleus. To make sure no other genes were involved, we performed the trio-based whole exome sequencing using the DNA samples from the proband and the parents, and no mutations were identified especially in DHH, NR0B1, NR5A1, SOX9 and MAP3K1, indicating the de novo mutation in SRY is the single defect responsible for the female sex reversal. We also used bioinformatics simulation analysis to predict impact of the mutation on SRY function, and find the R75 in wild type SRY can form a hydrogen bond with serine at 91 (S91) that make the SRY protein well fit into the minor groove of target DNA, while the M75 in the mutated SRY can't. Finally, we reviewed SRY mutations based on the available references and analyzed the mutation distribution patterns according to density and continuity, which may be useful for further study of the SRY structure, function, and its relatedness with DSD.
Use of fosfomycin combination therapy to treat multidrug-resistant urinary tract infection among paediatric surgical patients - a tertiary care centre experience
Authors: Shiju K S, Gopichand Pallam, Jharna Mandal, Bibekanand Jindal, Kumaravel S
Journal: Access Microbiol (2020)
Keywords: amikacin, combination, complicated urinary tract infection, fosfomycin, meropenem, multidrug-resistant organisms
MeSH terms: Case Reports

With increasing resistance to currently used antibiotics, antibiotic combinations are being resorted to. The present study deals with five children with complicated urinary tract infection (UTI) whose urine cultures grew multidrug-resistant (MDR) organisms. In all of these five cases, MDR organisms were the causative agents for UTI and the currently available antibiotics, including colistin, were ineffective, although the organisms were sensitive in vitro. In all of these cases, the isolates reverted to being susceptible to the quinolones and cephalosporins tested, namely ceftriaxone and ceftazidime. All were treated using a combination of fosfomycin with other antibiotics, since it has no interference with other classes of antibiotics. Our observations suggest that the use of a combination of fosfomycin with either a carbapenem or an aminoglycoside in a clinical setting would be a reasonable choice to treat UTIs caused by MDR organisms, especially in complicated cases that require chronic therapy.
Body Dysmorphic Disorder Insights in an Inpatient Psychiatric Setting
Authors: Zachary A Koenig, Sarah Callaham, Brittany Waltz, Julie Bosley, Raja Mogallapu, Michael Ang-Rabanes
Journal: Case Rep Psychiatry (2021)
MeSH terms: Case Reports

Body dysmorphic disorder is a chronic disorder involving imagined or partial appearance defects that lead to significant impairment in everyday life. It is quite prevalent but remains a clinically underdiagnosed psychiatric condition especially in the inpatient psychiatric setting. Onset of body dysmorphic disorder typically begins in adolescence with subclinical symptoms. Over time, symptoms progress to patients meeting the full Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) criteria. Severe cases of the body dysmorphic disorder are often camouflaged by concurrent diseases like major depressive disorder, obsessive-compulsive disorder, substance use disorder, and social anxiety disorder. Further, compounding the complexity of body dysmorphic disorder is a treatment of patients who present with coinciding suicidal ideations. Here, we present a unique case of a 40-year-old female admitted to an inpatient psychiatric unit for treatment of ongoing depression and suicidal symptoms. Early on in her inpatient course, she had symptoms of obsessive-compulsive disorder, social anxiety disorder, and alcohol use disorder. The constellation of symptoms prompted evaluation for body dysmorphic disorder and subsequent targeted treatment. This case report highlights the complexities associated with diagnosing body dysmorphic disorder, the importance of considering it a branch point for other psychiatric conditions, and the treatment for patients who present with coinciding suicidal behavior.
Vaginal cuff dehiscence following transvaginal oocyte retrieval: a case report
Authors: Sarah K O'Connor, David A Ryley, Charles W Obasiolu, Katharine M Esselen, Christine C Skiadas, Wendy Kuohung
Journal: Fertil Res Pract (2020)
Keywords: endometrial cancer, infertility, vaginal cuff dehiscence, vaginal oocyte retrieval
MeSH terms: Case Reports

Background:
Vaginal cuff dehiscence (VCD) is a rare but potentially serious complication following hysterectomy with an estimated incidence of 0.14-1.4%. There is a wide range of risk factors thought to contribute to VCD, but due to its rare occurrence, much still remains to be learned about the true impact of risk factors leading to dehiscence. We present here the second known report of VCD to occur in a patient undergoing transvaginal oocyte retrieval during her fertility treatment. This case highlights what may become a more common clinical scenario as more premenopausal women are diagnosed with reproductive tract cancers and access assisted reproductive therapies to preserve fertility.
Case presentation:
Our patient is a 35-year-old G1 P0 A1 who had undergone ovary-sparing total laparoscopic hysterectomy (TLH) following diagnosis of endometrial adenocarcinoma. She underwent two in-vitro fertilization (IVF) cycles after TLH to bank frozen blastocysts, the first vaginal oocyte retrieval (VOR) taking place 12 weeks following hysterectomy. She experienced VCD during her second VOR that occurred 17 weeks after TLH, the second case of VCD to be reported in the literature during fertility preservation treatment following hysterectomy. The patient underwent an emergent and uncomplicated repair of the defect vaginally the same day.
Conclusions:
Currently there are no guidelines in place for women who have undergone hysterectomy with regard to when they can begin fertility treatment in the post-operative period. Based on now two case reports, it is worth considering extension of the typical 6-week timeline of avoidance of vaginal procedures to allow for full cuff healing. Infertility providers should also be mindful of limiting transvaginal ultrasounds where possible to reduce force along the cuff.
Cardiac Implantable Electronic Device Infections-Decision-Making Process in Complex Patients: Report of 3 Cases
Authors: Assad Mohammedzein, Aaisha Mozumder, Scott Milton
Journal: J Investig Med High Impact Case Rep (2019)
Keywords: cardiac implantable electronic devices, endocarditis, lead infection, pocket infection
MeSH terms: Clinical Decision-Making, Defibrillators, Implantable / adverse effects, Electronics, Medical / instrumentation, Prosthesis-Related Infections / etiology, Prosthesis-Related Infections / microbiology, Case Reports, Review, Adult, Aged, 80 and over, Comorbidity, Device Removal, Electronics, Humans, Interdisciplinary Communication, Male, Middle Aged

Cardiac implantable electronic devices infections are becoming increasingly frequent with more of these devices being implanted in elderly patients with multiple comorbidities. They carry high morbidity and mortality if not treated promptly, which often entails removal of the entire system. Early recognition is paramount, and a multidisciplinary team is required. In this case report, we go through unique and challenging presentations of such patients with cardiac implantable electronic devices-related issues who presented to our institution, and we describe individual approaches to management and review the literature.
Anaesthesia for emergency caesarean section in a patient with large anterior mediastinal tumour presenting as intrathoracic airway compression and superior vena cava obstruction
Authors: James C S Chiang, Michael G Irwin, A Hussain, Y K Tang, Y T Hiong
Journal: Case Rep Med (2010)
MeSH terms: Case Reports

Anterior mediastinal mass is an uncommon pathology that presents significant anaesthetic challenges because of cardiopulmonary compromise. We present a case that presented in the third trimester of pregnancy with severe breathlessness, orthopnoea, and symptoms of superior vena cava obstruction. The patient had emergency Caesarean section under epidural anaesthesia with a good outcome. The paper discusses the relevant perioperative considerations for this complex scenario and reviews reports of similar conditions.
Unusual presentation of chronic hyperplastic pulpitis: a case report
Authors: Javad Faryabi, Shahrzad Adhami
Journal: Iran Endod J (2008)
Keywords: case reports, dental pulp diseases
MeSH terms: Case Reports

Chronic hyperplastic pulpitis (pulp polyps) usually occurs in molar teeth of children and young adults and is characterized by an overgrowth of granulomatous tissue into the carious cavity. Here, we report a rare type of pulp polyp in lower third molar of a 27-year-old woman that not only grow into carious cavity but also extruded in very large size that interfered with occluding of the teeth.
Cystic brain metastases in ALK-rearranged non-small cell lung cancer
Authors: Guilherme Nader Marta, Renata Rodrigues da Cunha Colombo Bonadio, Renata Eiras Martins, Henrique Bortot Zuppani, Gilberto de Castro Junior
Journal: Ecancermedicalscience (2018)
Keywords: anaplastic lymphoma kinase, crizotinib, cystic brain metastases, neurocysticercosis, non-small cell lung cancer
MeSH terms: Review

The central nervous system (CNS) is a common site of disease progression in patients with non-small-cell lung cancer (NSCLC) with anaplastic lymphoma kinase (ALK)-rearrangement treated with crizotinib. Cystic brain metastases (CBM) have been recently identified as one possible variant of this disease. An illustrative case report is presented along with a literature review performed in order to track relevant papers about CBM in ALK-rearranged NSCLC, including possible pathophysiology, differential diagnosis and treatment options for this condition. Three case reports have been published describing six ALK-rearranged NSCLC patients presenting with CBM, all of which were under treatment with crizotinib by the time of CBM diagnosis. Treatment with CNS-penetrating tyrosine kinase inhibitors (TKIs) resulted in CNS disease control in three of the six cases reported either as single therapy or in combination with radiation therapy (RT). Investigation of differential diagnoses of CBM might be necessary, which include inflammatory and demyelinating disorders, primary brain tumours and infectious diseases, especially neurocysticercosis that might mimic CBM images. Treatment options include RT, CNS-penetrating TKIs and invasive procedures, such as stereotactic drainage. Thus, CBM are associated with ALK-rearranged NSCLC, particularly in patients who use crizotinib and should prompt investigation of differential diagnosis. CNS-penetrating TKIs are effective in the control of solid brain metastases and also seem to be active in CBM as single therapy or in combination with RT.
Iatrogenic central retinal artery occlusion after carotid body tumor embolization and excision
Authors: Carlos M Rangel, Sergio Jaramillo, Clara L Varón, Angélica M Prada
Journal: GMS Ophthalmol Cases (2017)
Keywords: carotid body tumor, central retinal artery occlusion, embolization, iatrogenic, paraganglioma, polyvynil alcohol, trys-acryl gelatin
MeSH terms: Case Reports

Objective: To report a case of iatrogenic central retinal artery occlusion after embolization and surgical resection of carotid body paraganglioma. Methods: Case report Results: One adult female patient presented with persistent unilateral visual loss after embolization with Embosphere® and Contour® microparticles of carotid body tumor. Fluorescein angiography revealed intraluminal microspheres in the central retinal artery ramifications. OCT revealed intraretinal spherical, hyporeflective particles with posterior shadowing. Conclusions: Central retinal artery occlusion should be assessed as a possible complication after surgical repair of head and neck paragangliomas.
Clear Cell Carcinoma Arising from Ovarian and Thoracic Endometriosis: A Case Report and Review of Literature
Authors: Samantha Mendoza Stanteen, Taemee Pak, Hao Chen, Matthew Carlson, Jessica Lee
Journal: Case Rep Obstet Gynecol (2022)
MeSH terms: Case Reports

We report a case of stage IVB ovarian clear cell carcinoma in a 35-year-old female with a long-standing history of biopsy-proven pelvic and thoracic endometriosis. At the time of her ovarian cancer diagnosis, her tumors were found to be isolated to the sites of her previously known endometriotic lesions, suggesting that malignant transformation of her endometriosis to ovarian cancer had occurred. She underwent primary tumor debulking, then received six cycles of intravenous carboplatin and paclitaxel, and is now free of disease. We have conducted a literature review of ovarian cancers arising from endometriosis as well as a summary of the molecular basis on the relationship between endometriosis and malignant ovarian carcinoma.