OpenMed/multicare-articles huggingface dataset:
Strangulated sliding spigelian hernia: A case report
Authors: P O Igwe, N A Ibrahim
Journal: Int J Surg Case Rep (2018)
Keywords: nylon darn, strangulated sliding spigelian hernia

Introduction:
Spigelian hernia is uncommon and frequently presents with features of intestinal obstruction. Clinical diagnosis is difficult in patients without obvious abdominal mass and a computed tomography scan is very helpful in making diagnosis. We report a patient who presented with a strangulated sliding left sided spigelian hernia who was pre-operatively diagnosed and successfully managed surgically.
Presentation of case:
A 56-year-old woman was to referred to the surgical emergency unit of our institution with abdominal swelling and pain of three days. There was no abdominal distension or fever and had no history of recurrent abdominal pains, abdominal swelling or surgery. Examination revealed a middle aged woman with a tender mass measuring about 10 cm by 8 cm in the left iliac fossa region of the abdomen. Bowel sounds were hyperactive and digital rectal examination revealed an empty rectum consistent with the diagnosis of acute intestinal obstructions. Investigations done by the patient at the referring hospital included a computed tomography (CT) scan which was suggestive of an obstructed Spigelian hernia with the sac containing a small bowel loop and mesentery. She had emergency herniorrhaphy and findings were herniation through a facial defect of about 5 cm by 4 cm along the lateral border of the rectus sheath with the hernia sac containing sero-sanguineous peritoneal fluid, gangrenous ileal segment and part of herniated urinary bladder forming the lower wall of the sac. Resection of gangrenous bowel with an end to end anastomosis was carried out, viable contents of the sac were reduced and defect repaired with interrupted non absorbable sutures to approximate the internal oblique and transversus abdominis to rectus sheath. In addition, nylon darning from inguinal ligament to the rectus sheath was also done. Her post-operative recovery was satisfactory and she remained well six months after surgery.
Conclusion:
Pre-operative diagnosis of strangulated Spigelian hernia is difficult but can be aided by a CT. The use of nylon darning to re-inforce the repair can be rewarding where mesh cannot be used or unavailable.
Systemic Mastocytosis in a Patient with BCR-ABL1-Positive Chronic Myeloid Leukemia in the Remission Phase
Authors: Christos Fokoloros, Periklis Foukas, Nikolaos Georgakopoulos, Zoi Tsakiraki, Anthi Bouchla, Vasilliki Pappa, Alexandros Katoulis, Michael Makris, Sotirios Papageorgiou
Journal: Case Rep Hematol (2022)
MeSH terms: Case Reports

Systemic mastocytosis (SM) comprises a group of rare disorders resulting from tissue infiltration by pathological mast cells. In a percentage ranging from 5 to 40% in various patient series, SM appears to be associated with an accompanying hematologic neoplasm (SM-AHN). The coexistence of SM with chronic myelogenous leukemia (CML) is extremely rare with only 3 cases in the literature. The natural course of CML has changed dramatically over the past 2 decades with the use of tyrosine kinase inhibitors (TKIs). We report a case of diagnosing SM in a patient in complete molecular remission of CML after stopping TKI treatment.
Referred Trigeminal Facial Pain from Occipital Neuralgia Occurring Much Earlier than Occipital Neuralgia
Authors: Byung-Chul Son
Journal: Case Rep Neurol Med (2020)
MeSH terms: Case Reports

We report a very rare case in which a patient believed to have auriculotemporal neuralgia due to the repeated recurrence of paroxysmal stabbing pain in the preauricular temporal region for four years developed occipital neuralgia, which finally improved with decompression of the greater occipital nerve (GON). The pain of occipital neuralgia has been suggested to be referred to the frontoorbital (V1) region through trigeminocervical interneuronal connections in the trigeminal spinal nucleus. However, the reports of such cases are very rare. In occipital neuralgia, the pain referred to the ipsilateral facial trigeminal region reportedly also occurs in the V2 and V3 distributions in addition to that in the V1 region. In the existing cases of referred trigeminal pain from occipital neuralgia, continuous aching pain is usually induced, but in the present case, typical neuralgic pain was induced and diagnosed as idiopathic auriculotemporal neuralgia. In addition, recurrent trigeminal pain occurred for four years before the onset of occipital neuralgia. If the typical occipital neuralgia did not develop in four years, it would be impossible to infer an association with the GON. This case shows that the clinical manifestations of referred trigeminal pain caused by the sensitization of the trigeminocervical complex by chronic entrapment of the GON can be very diverse.
Ovarian cancer in a former asbestos textile factory worker: a case report
Authors: Sunwook Park, Jaechan Park, Eunsoo Lee, Huisu Eom, Mu Young Shin, Jungwon Kim, Dongmug Kang, Sanggil Lee
Journal: Ann Occup Environ Med (2018)
Keywords: asbestos, occupational diseases, ovarian neoplasm, spinning work, textile industry
MeSH terms: Case Reports

Background:
The International Agency for Research on Cancer (IARC) defined that asbestos is a group 1 substance that causes lung cancer, mesothelioma (pleura and peritoneum), laryngeal cancer, and ovarian cancer in humans. Many studies on lung cancer, and mesothelioma caused by asbestos exposure have been conducted, but there was no case report of ovarian cancer due to asbestos exposure in Korea. We describe a case of ovarian cancer caused by asbestos exposure in a worker who worked at an asbestos textile factory for 3 years and 7 months in the late 1970s.
Case presentation:
A 57-year-old woman visited the hospital because she had difficulty urinating. Ovarian cancer was suspected in radiologic examination, and exploratory laparotomy was performed. She was diagnosed with epithelial ovarian cancer. The patient did not undergo postoperative chemotherapy and recovered. She joined the asbestos factory in March 1976 and engaged in asbestos textile twisting and spinning for 1 year, 2 years and 7 months respectively. In addition, she lived near the asbestos factory for more than 20 years. There was no other specificity or family history.
Conclusion:
Considering the patient's occupational and environmental history, it is estimated that she had been exposed to asbestos significantly, so we determined that ovarian cancer in the patient is highly correlated with the occupational exposure of asbestos and environmental exposure is a possible cause as well. Social devices are needed to prevent further exposure to asbestos. It is also necessary to recognize that ovarian cancer can occur in workers who have previously been exposed to asbestos, and the education and social compensation for those workers are needed.
Androgen Deprivation Therapy for Prostatic Cancer in Patients With Torsades de Pointes
Authors: Pietro Enea Lazzerini, Iacopo Bertolozzi, Maurizio Acampa, Silvia Cantara, Maria Grazia Castagna, Laura Pieragnoli, Antonio D'Errico, Marco Rossi, Stefania Bisogno, Nabil El-Sherif, Mohamed Boutjdir, Franco Laghi-Pasini, Pier Leopoldo Capecchi
Journal: Front Pharmacol (2020)
Keywords: torsades de pointes, androgen deprivation therapy, prostatic cancer, sudden death, testosterone

Background:
Men normally have shorter heart rate-corrected QT interval (QTc) than women, at least in part due to accelerating effects of testosterone on ventricular repolarization. Accumulating data suggest that androgen-deprivation therapy (ADT) used for the treatment of prostatic cancer, may increase Torsades de Pointes (TdP) risk by prolonging QTc. However, the evidence for such an association is currently limited to few case reports, in most cases deriving from the analysis of uncontrolled sources such as pharmacovigilance databases.
Objective:
To better determine the clinical impact of ADT on TdP development, we examined the prevalence of this therapy in a consecutive cohort of 66 TdP patients, prospectively collected over a ~10 years period.
Methods and results:
We found and described four patients who were under ADT for prostatic cancer when TdP occurred, and in two cases degenerated to cardiac arrest. Notably, in this unselected population, ADTs unexpectedly represented the second most frequently administered QT-prolonging medication in males (4/24, 17%), after amiodarone. Moreover, in the ADT patients, a blood withdrawal was performed within 24 h from TdP/marked QTc prolongation occurrence and circulating concentration of androgens and gonadothropins were measured. As expected, all cases showed markedly reduced testosterone levels (total, free, and available).
Conclusion:
We provide evidence that a significant proportion of patients developing TdP were under treatment with ADT for prostatic cancer, thus confirming the clinical relevance of previous pharmacovigilance signals. An accurate assessment of the arrhythmic risk profile should be included in the standard of care of prostatic cancer patients before starting ADT.
Severe Recurrent Necrotizing Myopathy in Pregnancy: A Case Report
Authors: Yue Li, Lingchao Meng, Yun Yuan, Lijuan Meng, Jing Lin, Bitao Bu
Journal: Front Neurol (2018)
Keywords: immunological evidence, necrotizing autoimmune myopathy, pregnancy, relapse, tacrolimus
MeSH terms: Case Reports

Pregnancy in patients with necrotizing autoimmune myopathy without identified antibodies is rarely reported. We report a case involving a 26-year-old woman with antibody-negative autoimmune necrotizing myopathy who experienced a relapse during pregnancy. Before pregnancy, the patient's myopathy symptoms and elevated serum creatine kinase levels had been successfully controlled with oral prednisone and tacrolimus for 1 year. However, she discontinued the therapy on her own accord, with the aim of conceiving. During pregnancy, she experienced a very severe relapse of muscle weakness and dyspnea and her creatine kinase level increased to >8,000 U/L. After she was treated with intravenous immunoglobulin, oral prednisone, and tacrolimus, she slowly recovered and delivered a healthy neonate. She continues to take oral tacrolimus (3 mg/day) and has remained symptom-free 2 years later.
Case report: reverse lateral arm flap in a patient with previously harvested radial artery
Authors: Zahir T Fadel, Mohammed B Ashi, Weaam S Magram
Journal: Case Reports Plast Surg Hand Surg (2022)
Keywords: elbow reconstruction, flaps, olecranon wounds, posterior elbow wounds, upper extremity flaps
MeSH terms: Case Reports

The radial artery supplies various locoregional flaps used for elbow reconstruction. A reverse lateral arm flap is a reliable choice, despite sacrificing the radial artery in some cases. We describe using a reverse lateral arm flap for elbow soft tissue reconstruction in a patient with a previously harvested radial artery.
Identification of a rare de novo three-way complex t(5;20;8)(q31;p11.2;p21) with microdeletions on 5q31.2, 5q31.3, and 8p23.2 in a patient with hearing loss and global developmental delay: case report
Authors: Roland Haj, Kelly Jackson, Beth A Torchia, Lisa G Shaffer, Bassem A Bejjani, Gordon C Gowans, Michael W Ruff
Journal: Mol Cytogenet (2009)

Background:
Complex chromosome rearrangements (CCRs), which involve more than two breakpoints on two or more chromosomes, are uncommon occurrences. Although most CCRs appear balanced at the level of the light microscope, many demonstrate cryptic, submicroscopic imbalances at the translocation breakpoints.
Results:
We report a female with hearing loss and global developmental delay with a complex three-way unbalanced translocation (5;20;8)(q31;p11.2;p21) resulting in microdeletions on 5q31.2, 5q31.3, and 8p23.2 identified by karyotyping, microarray analysis and fluorescence in situ hybridization.
Discussion:
The microdeletion of bands 8p23.2 may be associated with the hearing impairment. Furthermore, the characterization of this patient's chromosomal abnormalities demonstrates the importance of integrated technologies within contemporary cytogenetics laboratories.
Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): A rare case after in vitro fertilization (IVF)
Authors: Ahmed Ghazi, Aqueela Ayaz, Tahira Hamid, Mian Usman Farooq, Nikita Islam
Journal: Pak J Med Sci (2017)
Keywords: hypercalcemia, in vitro fertilization, ovarian cancer, sccoht, small cell carcinoma
MeSH terms: Case Reports

Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a very rare and lethal tumor, mostly affecting young women, with aggressive clinical course. It has a worse prognosis in younger women and most of them died within two years of diagnosis. We are reporting a unique case of SCCOHT in a 35 years old, nulliparous lady with primary infertility in which symptomatic hypercalcemia was a presenting feature of her cancer. She was completely healthy before third cycle of IVF. Within two months of her third IVF cycle, she developed SCCOHT with a very rapid and aggressive course of disease and fatal outcome. Patient died within one month of her first symptom presentation (3 months after IVF cycle).
Mycotic aortic aneurysm in a debilitated patient with compromised immunity; beware of Candida!
Authors: Thilina Gunawardena, Manujaya Godakandage, Sachith Abeywickrama, Rezni Cassim, Mandika Wijeyaratne
Journal: J Vasc Bras (2021)
Keywords: candida, in situ repair, malignant otitis externa, mycotic aneurysm
MeSH terms: Case Reports

Candida is a rare cause of infected aortic aneurysms. We report the case of a diabetic patient with end stage kidney disease who underwent repair of a leaking abdominal aortic aneurysm. He was on long-term antibiotic treatment for malignant otitis externa. Candida albicans was isolated from the culture of the excised aneurysm wall. An infected aortic aneurysm due to Candida has not been previously reported in a patient with malignant otitis externa. This case report aims to highlight that Candida should be suspected as a cause of infected aortic aneurysms in patients with debilitation and chronic immunosuppression. Management of such cases can be extremely challenging, especially in resource-poor settings, and we will be touching upon the advantages and disadvantages of various treatment options.
Third party cord blood transplant boosts autologous hematopoiesis in a case of persistent bone marrow aplasia after double transplant failure for B-thalassemia major
Authors: Giuseppe Visani, Paola Picardi, Barbara Guiducci, Federica Loscocco, Claudio Giardini, Moira Lucesole, Sara Barulli, Teresa Ricciardi, Alessandro Isidori
Journal: Mediterr J Hematol Infect Dis (2013)
MeSH terms: Case Reports

A 9-year-old female received an allogeneic stem cell transplant (SCT) from an ABO-incompatible HLA-matched sibling for β-thalassemia major, without achieving a complete donor chimerism. Subsequently, the patient received five donor lymphocyte infusions, without increasing donor chimerism, and autologous SCT. Due to the persistent bone marrow aplasia, the patient received a second allogeneic SCT from the same donor without obtaining any engrafment. After the double transplant failure, we performed an unrelated transplant from a full-matched umbilical cord blood (UCBT) without administering any neither conditioning regimen nor GVHD prophylaxis. Forty days after UCBT, trilinear engraftment was documented. Surprisingly, the hematopoietic reconstitution was related to the re-expansion of the autologous (beta-thalassemic) hematopoietic stem cell, as documented by chimerism studies. At present, 30 months after UCBT, there is stable hematopoietic autologous reconstitution. This is the first description of the restoration of autologous hematopoiesis obtained with UCBT in a thalassemia-major patient after a double transplant failure.
Bamboo Leaf Sign as a Sensitive Magnetic Resonance Imaging Finding in Spinal Subependymoma: Case Report and Literature Review
Authors: Hiroyuki Toi, Yukari Ogawa, Keita Kinoshita, Satoshi Hirai, Hiroki Takai, Keijiro Hara, Nobuhisa Matsushita, Shunji Matsubara, Masaaki Uno
Journal: Case Rep Neurol Med (2016)

Background and Importance. Subependymoma occurs very rarely in the spinal cord. We report another case of spinal subependymoma along with a review of the literature and discussion of a radiological finding that is useful for preoperative diagnosis of this tumor. Clinical Presentation. A 51-year-old man presented with a 2-year history of progressive muscle weakness in the right lower extremity. Sagittal magnetic resonance imaging (MRI) showed spinal cord expansion at the Th7-12 vertebral level. Surgical resection was performed and the tumor was found to involve predominantly subpial growth. Histological diagnosis was subependymoma, classified as Grade I according to criteria of World Health Organization. We made an important discovery of what seems to be a characteristic appearance for spinal subependymoma on sagittal MRI. Swelling of the spinal cord is extremely steep, providing unusually large fusiform dilatation resembling a bamboo leaf. We have termed this characteristic MRI appearance as the "bamboo leaf sign." This characteristic was apparent in 76.2% of cases of spinal subependymoma for which MRI findings were reported. Conclusion. The bamboo leaf sign on spinal MRI is useful for differentiating between subependymoma and other intramedullary tumors. Neurosurgeons encountering the bamboo leaf sign on spinal MRI should consider the possibility of subependymoma.
Heterozygous Mutation in Adenosine Deaminase Gene in a Patient With Severe Lymphopenia Following Corticosteroid Treatment of Autoimmune Hemolytic Anemia
Authors: Serena I Tripodi, Paola Corti, Silvia Giliani, Arnalda Lanfranchi, Andrea Biondi, Raffaele Badolato
Journal: Front Pediatr (2018)
Keywords: ada, autoimmune diseases, corticosteroids, lymphopenia, primary immunodeficiency
MeSH terms: Case Reports

We describe a previously healthy 14-year-old girl with acute onset autoimmune hemolytic anemia, associated with severe but transient lymphopenia during corticosteroid therapy, without infectious episodes during follow-up. After detailed investigations to rule out an underlying immunodeficiency, we detected a heterozygous ADA gene mutation. This was associated with slightly increased blood levels of adenosine and deoxyadenosine nucleotides and with reduced ADA activity in red blood cells, but within the normal range. This observation suggests that heterozygous ADA mutation might be a predisposing factor for lymphopenia in patients receiving corticosteroid therapy.
Aplasia Cutis Congenita of the Lower Limb: A Case Report
Authors: Abdulwahab M Alharthi, Abdulhadi A Turkistani, Bader Alallah, Jubara Alallah
Journal: Cureus (2023)
Keywords: aplasia cutis congenita, bart's syndrome, congenital absence of skin, epidermolysis bullosa, genetic
MeSH terms: Case Reports

Aplasia cutis congenita type VI is a genetic disorder that presents with congenital skin absence, blistering, and nail abnormalities. We present the case of a male newborn who presented with an absence of skin in the entire left leg and the lower part of the left thigh. On the second day of life, he had new skin lesions that started to appear over the fingernail beds, nasal bridge, thighs, and buttocks. There were no other associated anomalies such as pyloric atresia, renal abnormalities, or ureteral stenosis. A diagnosis of Bart's syndrome was made based on clinical diagnosis and previous presentation in the family. The patient developed sepsis and osteomyelitis of the lower limb and eventually died.
Pulmonary Hypertension Secondary to Partial Anomalous Pulmonary Venous Return in an Elderly
Authors: Stefan Koester, Justin Z Lee, Kwan S Lee
Journal: Case Rep Cardiol (2016)

Background. Partial anomalous pulmonary venous return (PAPVR) is an uncommon congenital abnormality, which may present in the adult population. It is often associated with sinus venosus defect (SVD). The diagnosis and therapy for this condition may be challenging. Case Presentation. We describe a case of an elderly woman who presented with NYHA Class IV dyspnea and was suspected to have symptomatic pulmonary hypertension. She was later found to have anomalous right upper pulmonary vein return to the superior vena cava and associated SVD with bidirectional shunting. Therapeutic options were discussed and medical management alone with aggressive diuresis and sildenafil was adopted. Follow-up visits revealed success in the planned medical therapy. Conclusions. PAPVR is a rare congenital condition that may present during late adulthood. The initial predominant left-to-right shunting associated with this anomaly may go undetected for years with the gradual development of pulmonary hypertension and right heart failure due to right heart volume overload. Awareness of the condition is important, as therapy is time-sensitive with early detection potentially leading to surgical therapy as a viable option.
Bridging Myositis Ossificans After Supracondylar Humeral Fracture in a Child: A Case Report
Authors: Jiayuan Chen, Qilin Li, Tianjing Liu, Guoqiang Jia, Enbo Wang
Journal: Front Pediatr (2021)
Keywords: brachialis, child, myositis ossificans, operative treatment, supracondylar humerus fracture
MeSH terms: Case Reports

Background: Myositis ossificans is an uncommon complication of trauma and surgery, defined as ossifying changes in a non-osseous tissue such as muscles. It happens after tissue injury, with or without fractures. When myositis ossificans occurs around a joint, it can cause ankylosis, leading to complete dysfunction of the joint. Though it has been described in most parts of the body, bridging myositis ossificans involving the elbow joint were scarcely reported. Case Presentation: We report a severe case of myositis ossificans after a supracondylar humerus fracture in a 9-year-old child. In this case a palpable painless mass appeared following the fracture and surgical trauma. Ultrasound or X-ray is of significant diagnostic value. The brachialis was completely ossified and formed a bony bridge around the elbow, causing complete ankylosis. The bone mass was surgically removed through a bilateral less-invasive approach with less surgical trauma 9 months after initial presentation. we applied bone wax to the fresh bone wounds to prevent the formation of hematocele. Indomethacin, a non-steroidal anti-inflammatory drug, was administered after the operation to suppress bone proliferation in our case. Our patient had the best possible functional status and no recurrence at 2 years' follow-up. Conclusion: Elbow myositis ossificans in children may mainly affects the brachialis. A bilateral less-invasive approach is sufficient to remove the bone mass with less surgical trauma. This case also provides a new reference for the treatment of myositis ossificans after the elbow injuries.