OpenMed/multicare-articles huggingface dataset:
Text mining of online job advertisements to identify direct discrimination during job hunting process: A case study in Indonesia
Authors: Panggih Kusuma Ningrum, Tatdow Pansombut, Attachai Ueranantasun
Journal: PLoS One (2020)
MeSH terms: Advertising / methods, Data Mining / methods, Job Application, Prejudice, Social Discrimination, Workplace / psychology, Research Support, Non-U.S. Gov't, Age Factors, Female, Humans, Indonesia, Male, Marital Status, Physical Appearance, Body, Religion, Sex Factors

Discrimination in the workplace is illegal, yet discriminatory practices remain a persistent global problem. To identify discriminatory practices in the workplace, job advertisement analysis was used by previous studies. However, most of those studies adopted content analysis by manually coding the text from a limited number of samples since working with a large scale of job advertisements consisting of unstructured text data is very challenging. Encountering those limitations, the present study involves text mining techniques to identify multiple types of direct discrimination on a large scale of online job advertisements by designing a method called Direct Discrimination Detection (DDD). The DDD is constructed using a combination of N-grams and regular expressions (regex) with the exact match principle of a Boolean retrieval model. A total of 8,969 online job advertisements in English and Bahasa Indonesia, published from May 2005 to December 2017 were collected from bursakerja-jateng.com as the data. The results reveal that the practices of direct discrimination still exist during the job-hunting process including gender, marital status, physical appearances, and religion. The most recurrent type of discrimination which occurs in job advertisements is based on age (66.27%), followed by gender (38.76%), and physical appearances (18.42%). Additionally, female job seekers are found as the most vulnerable party to experience direct discrimination during recruitment. The results exhibit female job seekers face complex jeopardy in particular job positions comparing to their male counterparts. Not only excluded because of their gender, but female job seekers also had to fulfil more requirements for getting an opportunity to apply for the jobs such as being single, still at a young age, complying specific physical appearances and particular religious preferences. This study illustrates the power and potential of optimizing computational methods on a large scale of unstructured text data to analyze phenomena in the social field.
Secretory carcinoma of male breast: case report and review of the literature
Authors: S Gabal, S Talaat
Journal: Int J Breast Cancer (2011)
MeSH terms: Case Reports

Secretory carcinoma is a rare low-grade breast carcinoma, initially termed "juvenile breast cancer," but it is now known to occur in adults of both sexes. It is the only epithelial tumor of the breast with a balanced translocation, t(12;15), that creates an ETV6-NTRK3 gene translocation. In this paper, a 19-year-old male patient has had a right breast mass for 9 years which suddenly increased in size with no evidence of palpable axillary lymph nodes. The mass was excised for frozen section and was diagnosed as malignant growth for simple mastectomy. Microscopic examination revealed the classical features of secretory carcinoma. The tumor cells were positive for EMA and S-100 protein and focally positive for cytokeratin and ER but negative for progesterone receptor, CD34, and CEA. Four months later the patient developed ipsilateral axillary lymph node enlargement, with lymph node metastases in five of the dissected 19 lymph nodes. The patient was treated with six courses of chemotherapy and radiotherapy. Conclusion. Though considered an indolent neoplasm, secretory carcinoma does metastasize to lymph nodes. Surgery in the form of mastectomy with axillary clearance is the treatment of choice. This paper includes a rare case report of secretory carcinoma in young male patient, with axillary lymph node metastasis in spite of the indolent nature that this tumor is known to display.
Epidermoid cyst of perineum: a rare case in a young female
Authors: Uzma Saeed, Naveed Mazhar
Journal: BJR Case Rep (2016)
MeSH terms: Case Reports

Epidermoid cyst is a common, cutaneous, benign lesion that is frequently seen on the face, neck and trunk. It is rarely seen in the perineal region. The differential diagnosis of perineal cystic lesions includes a wide range of lesions, with an epidermoid cyst being a rare entity to be considered, and only a few such cases have been reported in the literature. Our case was a young Asian female who presented with painless perineal swelling for the past 6 months and was diagnosed as having an epidermoid cyst on the basis of diffusion-weighted MRI and contrast enhancement pattern, which was later confirmed by histopathological findings.
Case report: Favipiravir-induced bluish corneal discoloration in infant with COVID-19
Authors: Paveewan Jiravisitkul, Saraiorn Thonginnetra, Rintra Wongvisavavit
Journal: Front Pediatr (2023)
Keywords: covid-19, bluish discoloration, case report, cornea, favipiravir, infant
MeSH terms: Case Reports

This report describes a case of a male infant diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection who was prescribed favipiravir therapy. The mother noticed a discoloration of the child's eyes within 18 h of therapy, and the cornea returned to normal color within 5 days of medication cessation. This case report highlights the need for monitoring of favipiravir therapy in children due to the potential side effect of corneal discoloration, which has not yet had its long-term effects identified.
Case report: Surgical repair of congenitally corrected transposition of the great arteries with the guidance of three-dimensional printing
Authors: Yanchun Zhang, Yongnan Li, YuMei Ma, Yalin Wei, Fengxiao He, Yilin Zhu, Weixin Lu, Yinglu Zhao, Xiangyang Wu
Journal: Front Cardiovasc Med (2023)
Keywords: atrial septal defect (asd), congenitally corrected transposition of the great arteries (cctga), membranous ventricular septal aneurysm, pulmonary stenosis (ps), three-dimensional printing
MeSH terms: Case Reports

A 10-year-old girl presented with obvious cyanosis, and the saturation of arterial blood oxygen (SpO2) was decreased to 60.5% in the outpatient examination. Computed tomography angiography (CTA) and echocardiography suggested congenitally corrected transposition of the great arteries (ccTGAs), membranous ventricular septal aneurysm (MVSA), atrial septal defect (ASD), severe pulmonary stenosis (PS), and severe tricuspid regurgitation (TR). Due to the complex pathological anatomical structures, the three-dimensional printed model was used for preoperative assessment. After a comprehensive evaluation was completed, the operation was performed by physiological correction under cardiopulmonary bypass, including the resection of MVSA, repair using the bovine pericardial patch for ASD, and linear valvuloplasty of the tricuspid valve. Due to the special anatomical structures of ccTGA, PS was treated by extracardiac pipe technique. After the operation, the patient recovered well, cyanosis disappeared, SpO2 was up to 96%, and the extracardiac pipe was well-functioning without regurgitation or obstruction.
Acute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations
Authors: Benedetta Mariotti, Federico Meconi, Raffaele Palmieri, Eleonora De Bellis, Serena Lavorgna, Tiziana Ottone, Vincenza Martini, Francesco Lo-Coco, Laura Cicconi
Journal: Case Rep Hematol (2019)
MeSH terms: Case Reports

We present a case report of a patient with acute myeloid leukemia (AML) characterized by the simultaneous presence of nucleophosmin 1 (NPM1) mutation and the breakpoint cluster region-Abelson (BCR-ABL) fusion oncogene. Our findings emphasize the importance of routinely including BCR-ABL in the diagnostic workup of AML in order to offer to the patients the most appropriate risk category and treatment options.
Autoimmune Hypophysitis With Systemic Lupus Erythematosus: A Case Report and Literature Review
Authors: Pengyue Xiang, Qiuxia Wu, Hua Zhang, Chaoyang Luo, Huajie Zou
Journal: Front Endocrinol (Lausanne) (2020)
Keywords: anterior pituitary hypofunction, autoimmune disease, autoimmune hypophysitis, sella turcica, systemic lupus erythematosus
MeSH terms: Autoimmune Hypophysitis / pathology, Lupus Erythematosus, Systemic / pathology, Case Reports, Review, Aged, Autoimmune Hypophysitis / complications, Autoimmune Hypophysitis / drug therapy, Humans, Immunosuppressive Agents / therapeutic use, Lupus Erythematosus, Systemic / complications, Lupus Erythematosus, Systemic / drug therapy, Male, Prognosis, Immunosuppressive Agents

Background:
Autoimmune hypophysitis (AH) is a primary autoimmune inflammatory disorder of the pituitary gland, which usually presents as a mass in the sella turcica. Systemic lupus erythematosus (SLE) is another inflammatory disorder in which the immune system attacks healthy cells and tissues throughout the body. Although both diseases are autoimmune disorders, they rarely coexist, and the relationship between them is unclear.
Case report:
A 66-year-old man was evaluated at the endocrinology clinic because of worsening fatigue, anorexia, drowsiness, and leg oedema. Examination revealed alertness impairment and lower limb oedema. Laboratory tests showed anterior pituitary hypofunction. The treatment approach, with glucocorticoids and immunosuppressive agents, resulted in long-term remission of symptoms of hypopituitarism and hyponatraemia.
Conclusions:
Our case demonstrates a potential association between AH and SLE. AH may need to be considered in the evaluation of SLE patients with headache, hyperprolactinemia, a pituitary mass, and hypopituitarism.
Case Report: Novel compound heterozygous variants in CHRNA1 gene leading to lethal multiple pterygium syndrome: A case report
Authors: Jianlong Zhuang, Junyu Wang, Qi Luo, Shuhong Zeng, Yu'e Chen, Yuying Jiang, Xinying Chen, Yuanbai Wang, Yingjun Xie, Gaoxiong Wang, Chunnuan Chen
Journal: Front Genet (2022)
Keywords: chrna1, chromosomal microarray analysis, lethal multiple pterygium syndrome, stillbirth, whole-exome sequencing
MeSH terms: Case Reports

Background: Lethal multiple pterygium syndrome (LMPS) is a rare autosomal recessive inherited disorder typically characterized by intrauterine growth retardation, multiple pterygia, and flexion contractures. Case presentation: We herein report a Chinese case with a history of three adverse pregnancies demonstrating the same ultrasonic phenotypes, including increased nuchal translucency, edema, fetal neck cystoma, reduced movement, joint contractures, and other congenital features. Whole-exome sequencing (WES) revealed novel compound heterozygous variants in the CHRNA1 gene NM_000079.4: c.[1128delG (p.Pro377LeufsTer10)]; [505T>C (p.Trp169Arg)] in the recruited individual, and subsequent familial segregation showed that both parents transmitted their respective mutation. Conclusion: For the first time, we identified an association between the CHRNA1 gene and the recurrent lethal multiple pterygium syndrome (LMPS) in a Chinese family. This finding may also enrich the mutation spectrum of the CHRNA1 gene and promote the applications of WES technology in etiologic diagnosis of ultrasound anomalies in prenatal examination.
Myeloid sarcoma presenting with leukemoid reaction in a child treated for acute lymphoblastic leukemia
Authors: Aylin Canbolat Ayhan, Cetin Timur, Seyma Sonmez, Ebru Zemheri, Asım Yoruk
Journal: Case Rep Hematol (2014)

Background. Myeloid sarcoma is an extramedullary neoplasm of immature myeloid cells. Our study reports a presentation of myeloid sarcoma which presented with severe leukemoid reaction as a secondary malignancy in a patient who was treated for acute lymphoblastic leukemia previously. The case emphasizes the difficulties in diagnosis of patients who do not have concomitant leukemia. Case Presentation. A 6-year-old girl who was treated for acute lymphoblastic leukemia previously presented with fatigue, paleness, and hepatosplenomegaly. Peripheral blood smear and bone marrow aspirate examination did not demonstrate any blasts in spite of severe leukemoid reaction with a white cell count 158000/mm(3). FDG/PET CT revealed slight uptake in cervical and supraclavicular lymph nodes. Excisional lymph node biopsy was performed from these lymph nodes and it showed myeloid sarcoma. Conclusion. Myeloid sarcoma can develop as a secondary malignancy in children who are treated for acute lymphoblastic leukemia. It can be associated with severe leukemoid reaction and diagnosis may be difficult if there is not concomitant leukemia. PET/CT is helpful in such cases.
Severe Disseminated Infection with Emerging Lineage of Methicillin-Sensitive Staphylococcus aureus
Authors: Paul Jewell, Luke Dixon, Aran Singanayagam, Rohma Ghani, Ernie Wong, Meg Coleman, Bruno Pichon, Angela Kearns, Georgina Russell, James Hatcher
Journal: Emerg Infect Dis (2019)
Keywords: antimicrobial resistance, mrsa, mrsa and other staphylococci, mssa, staphylococcus aureus, bacteria, epidural abscess, flucloxacillin, methicillin-resistant staphylococcus aureus, methicillin-sensitive staphylococcus aureus, psoas abscess, retropharyngeal abscess, virulence factors
MeSH terms: Anti-Bacterial Agents / administration & dosage, Floxacillin / administration & dosage, Staphylococcal Infections / diagnostic imaging, Staphylococcus aureus / isolation & purification, Case Reports, Administration, Intravenous, Humans, Immunocompetence, Magnetic Resonance Imaging, Male, Methicillin / pharmacology, Middle Aged, Staphylococcal Infections / drug therapy, Staphylococcal Infections / microbiology, Staphylococcal Infections / surgery, Staphylococcus aureus / drug effects, Tomography, X-Ray Computed, Treatment Outcome, Whole Genome Sequencing, Anti-Bacterial Agents, Floxacillin, Methicillin

We report a case of severe disseminated infection in an immunocompetent man caused by an emerging lineage of methicillin-sensitive Staphylococcus aureus clonal complex 398. Genes encoding classic virulence factors were absent. The patient made a slow recovery after multiple surgical interventions and a protracted course of intravenous flucloxacillin.
Case report: Spontaneous remission in lung carcinoma with a late relapse after adjuvant immunotherapy: Exceptional tumor micro-environment
Authors: Yan Chen, Wenhui Guan, Changhao Zhong, Jiaxi Deng, Minjuan Hu, Wenwei Mo, Xiaohong Xie, Shiyue Li, Chengzhi Zhou, Xinqing Lin
Journal: Front Immunol (2023)
Keywords: adjuvant immunotherapy, immune checkpoint inhibitors, non-small cell lung cancer, spontaneous remission, tumor immune microenvironment
MeSH terms: Carcinoma, Non-Small-Cell Lung / drug therapy, Carcinoma, Non-Small-Cell Lung / pathology, Carcinoma, Squamous Cell / drug therapy, Carcinoma, Squamous Cell / pathology, Lung Neoplasms / pathology, Case Reports, Adjuvants, Immunologic / therapeutic use, Chronic Disease, Humans, Immunotherapy, Lung / pathology, Neoplasm Recurrence, Local / pathology, Remission, Spontaneous, Tumor Microenvironment, Adjuvants, Immunologic

Spontaneous remission (SR) of local recurrence after adjuvant immunotherapy has rarely been reported, and the underlying mechanism is poorly understood. Herein, we reported a patient with stage cT2aN2M0 squamous cell lung carcinoma who received neoadjuvant and adjuvant treatment with nivolumab plus chemotherapy. The patient experienced a late relapse in the subcarinal lymph node seven months after the last dosage of treatment but achieved SR in the next three months without additional antitumor therapy. The complete response lasted for eleven months and counting. Notably, high copies of pathogenic microorganisms were detected in the patient's bronchoalveolar lavage fluid along with the recurrence but disappeared after SR. The patient also experienced a lymph node puncture-induced fever but had no other symptoms. A longitudinal analysis of infiltrated immune cells in the recurrent lymph node was performed by multiplex immunofluorescence and whole transcriptome sequencing, which revealed that CD8+ T cells were recruited during the initial relapse, specifically in the stromal area, then migrated into the tumor tissue, and continued to increase after elimination of tumor cells. Meanwhile, the initial recruitment of CD8+ T cells was coupled with a higher proportion of B cells, and the abundant neutrophil population was synchronous with the infiltration of CD8+ T cells into tumor cells. This is the first report on an Non-small cell lung cancer (NSCLC) patient with a late relapse after adjuvant immune checkpoint inhibitor (ICI) therapy who achieved SR. Our case highlights the complexity and plasticity of antitumor immunity and is expected to help find efficient strategies against the resistance of ICI treatment.
Ross River virus disease reemergence, Fiji, 2003-2004
Authors: Philipp Klapsing, J Dick MacLean, Sarah Glaze, Karen L McClean, Michael A Drebot, Robert S Lanciotti, Grant L Campbell
Journal: Emerg Infect Dis (2005)
MeSH terms: Alphavirus Infections / diagnosis, Ross River virus / isolation & purification, Case Reports, Adult, Alphavirus Infections / epidemiology, Disease Outbreaks, Female, Fiji / epidemiology, Humans, Male

We report 2 clinically characteristic and serologically positive cases of Ross River virus infection in Canadian tourists who visited Fiji in late 2003 and early 2004. This report suggests that Ross River virus is once again circulating in Fiji, where it apparently disappeared after causing an epidemic in 1979 to 1980.
Liver transplantation for hepatic trauma: Discussion about a case and its management
Authors: Charles Honoré, Arnaud Deroover, Nathalie Gilson, Olivier Detry
Journal: J Emerg Trauma Shock (2011)
Keywords: liver trauma, damage control surgery, transplantation
MeSH terms: Case Reports

Liver transplant for trauma is a rare condition with 19 cases described in the literature. We report the case of a 16-year-old patient who suffered a gradeV liver injury with a vena cava tear after a car crash. After a computerized tomography (CT) scan, the patient was directly sent to the operating room where the surgeon performed a right hepatectomy extended to segment IV with a venous repair under discontinued hilar clamping. On day five, the patient developed acute liver failure and was put on an emergency transplant waiting list. He had a successful liver transplant 2 days later. Fifteen months after his transplant, the patient is alive and asymptomatic. This case report focuses on the patient's initial management, the importance of damage control surgery and the circumstances which finally led to the transplant.
Neurological complications and death in children with dengue virus infection: report of two cases
Authors: Neydi Osnaya-Romero, Maria-Gabriela Perez-Guille, Sandra Andrade-García, Erika Gonzalez-Vargas, Rebeca Borgaro-Payro, Sandra Villagomez-Martinez, José de Jesús Ortega-Maldonado, Jose Luis Arredondo-García
Journal: J Venom Anim Toxins Incl Trop Dis (2017)
Keywords: children, death, dengue, dengue virus, neurological disorders
MeSH terms: Case Reports

Background:
Dengue virus infection can have different complications; the best known is hemorrhagic dengue fever. However, other effects such as neurological disorders may endanger the lives of patients. Dengue neurological manifestations can be confused with encephalitis symptoms and can lead to cerebral edema and death. Therefore, we consider important in the endemic areas to take into account the diagnosis of dengue encephalitis in patients with neurological disorders, and to request the determination of serology in cerebrospinal fluid for the NS1 antigen test.
Case presentation:
We present the cases of two patients from the state of Morelos, Mexico, with 17 and 14 years of age. Both cases presented a rapid evolution characterized by fever, seizures and neurological deterioration secondary to severe cerebral edema that evolved to cerebral death in both cases. The diagnosis of brain death was confirmed by electroencephalogram in both patients. The two patients were submitted to serology for NS1 that tested positive in both cases. They died between the second and fifth day after admission.
Conclusions:
Retrospective studies have found that up to 4% of the patients have dengue virus infections, which leads us to believe that in endemic areas, this infection should be suspected in cases of encephalic and febrile symptoms. RT-PCR should be performed to identify cases of encephalitis caused by the dengue virus, and early interventions should be performed to attempt to reduce the morbidity and mortality of these cases.
Juvenile Psammomatoid Ossifying Fibroma (JPOF) of Proximal Radius: A Rare Entity
Authors: Jagadish Prabhu, Veena Nagaraj, Iftikhar Ahmed Mukhtar
Journal: Open Orthop J (2017)
Keywords: juvenile ossifying fibroma, ossifying fibroma, psammomatoid

Background:
Juvenile psammomatoid ossifying fibroma (JPOF) is a rare fibro-osseous lesion that usually occurs in the facial bones. The pathognomonic histopathologic feature is the presence of spherical ossicles, which are similar to psammoma bodies. It is considered to be a unique lesion because of its reported tendency to occur in children and adolescents and its tendency for locally aggressive growth. Because this lesion is aggressive in nature with high recurrence rate, early detection and complete surgical excision are essential.
Case report:
Herein, we present a case of 11 year old girl, who presented to our clinic with history of gradual onset pain around right elbow associated with limitation of right forearm rotation for 3 months. After getting informed consent, we performed needle biopsy and histopathologically it was diagnosed as Psammomatoid type juvenile ossifying fibroma (JPOF) of proximal radius. We performed extensive debridement, curettage of entire cystic lesion involving the proximal radius and filled the cavity with allograft bone granules and intramedullary titanium elastic nail through fibular strut graft, bridging the cystic lesion.
Conclusion:
As far as our knowledge there is no reported case of psammomatoid type of juvenile ossifying fibroma of proximal radius. We believe that such tumors in long bones are aggressive and have tendency for recurrence. Definitive diagnosis is utmost important for proper planning, surgical excision and reconstruction of long bones and need regular follow up to look for any recurrence or malignant transformation.
Neonatal lupus erythematosus: a cutaneous cases based update
Authors: Francesco Savino, Serena Viola, Valentina Tarasco, Emanuela Locatelli, Alberto Ricagni, Paola Coppo
Journal: Ital J Pediatr (2016)
MeSH terms: Lupus Erythematosus, Cutaneous / congenital, Lupus Erythematosus, Cutaneous / therapy, Case Reports, Diagnosis, Differential, Female, Head, Humans, Infant, Infant, Newborn, Male

Background:
Neonatal Lupus Erythematosus (NLE) is an uncommon autoimmune disease characterized by cutaneous, hepatic, hematological, neurological and cardiac involvement.
Case presentation:
Here we report four cases of cutaneous NLE which were referred to our department in the last 10 years and update literature. The newborns presented with different skin, clinical and laboratory features. This underlines the phenotypic variability of NLE. We investigated the passage of maternal antinuclear antibodies (ANA) and extractable nuclear antigen antibodies (ENA) - particularly anti-Ro/SSA, anti-La/SSB and anti-U1 ribonucleoprotein RNP - through the placenta. Despite the positive family background, cutaneous NLE and serological data improved in infants within 4 months without treatment.
Conclusion:
The evolution of cutaneous NLE may be the spontaneous regression of lesions within six months without progression to Systemic Lupus Erytehmatosus.