OpenMed/multicare-articles huggingface dataset:
Epidemiology, Seasonality and Treatment of Hospitalized Adults and Adolescents with Influenza in Jingzhou, China, 2010-2012
Authors: Jiandong Zheng, Xixiang Huo, Yang Huai, Lin Xiao, Hui Jiang, John Klena, Carolyn M Greene, Xuesen Xing, Jigui Huang, Shali Liu, Youxing Peng, Hui Yang, Jun Luo, Zhibin Peng, Linlin Liu, Maoyi Chen, Hui Chen, Yuzhi Zhang, Danqin Huang, Xuhua Guan, Luzhao Feng, Faxian Zhan, Dale J Hu, Jay K Varma, Hongjie Yu
Journal: PLoS One (2016)
MeSH terms: Hospitalization, Influenza, Human / epidemiology, Seasons, Research Support, U.S. Gov't, P.H.S., Acute Disease, Adolescent, Adult, Aged, China / epidemiology, Female, Humans, Male, Middle Aged, Young Adult

Background:
After the 2009 influenza A (H1N1) pandemic, we conducted hospital-based severe acute respiratory infection (SARI) surveillance in one central Chinese city to assess disease burden attributable to influenza among adults and adolescents.
Methods:
We defined an adult SARI case as a hospitalized patient aged ≥ 15 years with temperature ≥38.0°C and at least one of the following: cough, sore throat, tachypnea, difficulty breathing, abnormal breath sounds on auscultation, sputum production, hemoptysis, chest pain, or chest radiograph consistent with pneumonia. For each enrolled SARI case-patient, we completed a standardized case report form, and collected a nasopharyngeal swab within 24 hours of admission. Specimens were tested for influenza viruses by real-time reverse transcription polymerase chain reaction (rRT-PCR). We analyzed data from adult SARI cases in four hospitals in Jingzhou, China from April 2010 to April 2012.
Results:
Of 1,790 adult SARI patients enrolled, 40% were aged ≥ 65 years old. The median duration of hospitalization was 9 days. Nearly all were prescribed antibiotics during their hospitalization, less than 1% were prescribed oseltamivir, and 28% were prescribed corticosteroids. Only 0.1% reported receiving influenza vaccination in the past year. Of 1,704 samples tested, 16% were positive for influenza. Influenza activity in all age groups showed winter-spring and summer peaks. Influenza-positive patients had a longer duration from illness onset to hospitalization and a shorter duration from hospital admission to discharge or death compared to influenza negative SARI patients.
Conclusions:
There is substantial burden of influenza-associated SARI hospitalizations in Jingzhou, China, especially among older adults. More effective promotion of annual seasonal influenza vaccination and timely oseltamivir treatment among high risk groups may improve influenza prevention and control in China.