OpenMed/multicare-articles huggingface dataset:
Case Report: Disease progression of renal cell carcinoma containing a novel putative pathogenic KAT6A::NRG1 fusion on Ipilimumab- Nivolumab immunotherapy. A case study and review of the literature
Authors: Almas Dawood, Suzanne MacMahon, My-Anh Tran Dang, Maxine G B Tran, Axel Bex, Ekaterini Boleti, Soha El Sheikh
Journal: Front Oncol (2023)
Keywords: kat6a, nrg1, fusion, immunotherapy, mutation, renal cell carcinoma
MeSH terms: Case Reports

Renal cell carcinoma still carries a poor prognosis despite therapeutic advancements. Detection of genetic mutations is vital in improving our understanding of this disease as well as potential role in targeted therapy. Here we present a case of a 49 year old man with an aggressive renal cell carcinoma bearing a novel pathogenic KAT6A::NRG1 fusion. We will explore the clinical presentation, histological and molecular diagnostics, treatment and disease progression. We will discuss the relevance of this unique fusion and comparisons with cancer cases with similar genetic mutations. Further research is warranted for such cases, in order to facilitate better targeted treatments.
Penetrating thoracic ice pick injury extending into pulmonary artery: Report of a case
Authors: Marina Kawaguchi, Hirotsugu Yamamoto, Taihei Yamada, Tetsuya Yumoto, Toshiyuki Aokage, Hiromi Ihoriya, Koki Eto, Takanori Suezawa, Hiromichi Naito, Atsunori Nakao
Journal: Int J Surg Case Rep (2018)
Keywords: case report, emergency surgery, penetrating chest injury, pulmonary artery

Introduction:
Penetrating thoracic traumas have a wide spectrum, ranging from mild traumas to life-threatening injuries.
Presentation of case:
This paper illustrates a 40-year-old male with a penetrating pulmonary artery injury that was successfully treated with emergency surgery. The patient visited local hospital by foot complaining of moving object on his chest and was found that an ice pick was penetrating the man's left chest. An ambulance took the patient to our emergency department. Computed tomography of the chest showed linear metallic density in the pulmonary trunk and a small amount of pericardial fluid. Emergency surgery for removal of the object and repair of the pulmonary artery was performed. The ice pick had been stuck in the main pulmonary artery through the pericardium without any injury to the left lung or internal thoracic artery. Postoperative course was uneventful.
Discussion:
A multidisciplinary team designed our treatment strategy, enabling us to select the optimal treatment, including diagnostic techniques and surgical approach. A successful trauma management depends on whether a life-threatening conditionexists. Major vascular injury should be rapidly assessed in these cases. Psychiatric aspects of the case are also discussed.
Conclusion:
Early removal of the foreign body is recommended to prevent further damage to the heart.
Unusual tumours of the heart: diagnostic and prognostic implications
Authors: Zeena Makhija, Ranjit Deshpande, Jatin Desai
Journal: J Cardiothorac Surg (2009)
MeSH terms: Carcinoma, Squamous Cell / diagnosis, Heart Neoplasms / diagnosis, Myxoma / diagnosis, Thrombosis / diagnosis, Case Reports, Aged, Breast Neoplasms / pathology, Carcinoma, Squamous Cell / secondary, Diagnosis, Differential, Female, Heart Diseases / diagnosis, Heart Neoplasms / secondary, Humans, Male, Middle Aged, Rectal Neoplasms / pathology, Tongue Neoplasms / pathology

Metastases to the heart are extremely uncommon. We describe three unusual cases along with their management. A review of the current literature concerning cardiac secondaries is included.
Oxaliplatin-Induced Lhermitte's Sign in Gastric Cancer
Authors: Takeshi Okamoto, Koichi Takagi, Katsuyuki Fukuda
Journal: Case Rep Oncol Med (2020)
MeSH terms: Case Reports

A 64-year-old Japanese man with no significant medical history presented with epigastric discomfort of 2-weeks' duration. He was diagnosed with metastatic HER2-positive gastric cancer. Chemotherapy with capecitabine, oxaliplatin, and trastuzumab was initiated. During the eighth cycle, he suddenly complained of electric shock-like pain in both legs upon neck flexion, consistent with Lhermitte's sign. Oxaliplatin was discontinued, and Lhermitte's sign resolved after 3 months. Neurotoxicity is commonly observed in platinum-based chemotherapy, but Lhermitte's sign is rare. This is the first report of oxaliplatin-induced Lhermitte's sign in a gastric cancer patient.
Correction of multiple canine impactions by mixed straightwire and cantilever mechanics: a case report
Authors: Sergio Paduano, Iacopo Cioffi, Giorgio Iodice, Vincenzo d'Antò, Francesco Riccitiello, Gioacchino Pellegrino, Rosa Valletta
Journal: Case Rep Dent (2014)

Background. This case report describes the orthodontic treatment of a woman, aged 17 years, with a permanent dentition, brachyfacial typology, Angle Class I, with full impaction of two canines (13,33), and a severe ectopy of the maxillary left canine. Her main compliant was the position of the ectopic teeth. Methods. Straightwire fixed appliances, together with cantilever mechanics, were used to correct the impaired occlusion and to obtain an ideal torque control. Results and Conclusion. The treatment objectives were achieved in 26 months of treatment. The impactions were fully corrected with an optimal torque. The cantilever mechanics succeeded in obtaining tooth repositioning in a short lapse of time. After treatment, the dental alignment was stable.
Identification of small segmental translocations in patients with repeated implantation failure and recurrent miscarriage using next generation sequencing after in vitro fertilization/intracytoplasmic sperm injection
Authors: Jian Ou, Wei Wang, Tao Feng, Lianming Liao, Qingxia Meng, Qinyan Zou, Jie Ding, Aiyan Zheng, Chengying Duan, Peipei Li, Qiang Liu, Chunhua Lin, Hong Li
Journal: Mol Cytogenet (2015)
Keywords: array cgh, ngs, pgs, rif, rm, translocation
MeSH terms: Case Reports

Background:
To develop a novel preimplantation genetic screening (PGS) test using next generation sequencing(NGS) as a alternative to current array comparative genomic hybridization (array CGH) method for detection of small segmental translocations in two patients with repeated implantation failure (RIF) and recurrent miscarriage (RM). Inconsistent results were resolved by validation with fluorescence in situ hybridization (FISH).
Case presentation:
One couple with normal cytogenetic and array CGH result suffered from implantation failure. Later NGS analysis showed 46,XY.ngs[GRCh37/hg19] 9p24.3-9p24.1(10,291-8,680,890×1),13q33.1-13q34(103,046,327-114,785,444×3). The other couple with normal cytogenetic and array CGH result also received NGS analysis. Due to the detected abnormal finding, which was 46,XY.ngs 4q34.3-4q35.2(179,673,982-191,016,503×3),6p25.3-6p22.3 (146,672-17,829,693×1), the couple decided against the corresponding embryo transfer.
Conclusions:
The NGS approach is a reliable alternative to array CGH for the discovery of small segmental translocations in patients with RIF and RM.
Coronary Embolism and Myocardial Infarction in a Transgender Male Undergoing Hormone Therapy: A Case Report and Review of the Literature
Authors: Sandesh Dinesh, Marcus Franz, Friedhelm Küthe
Journal: Case Rep Cardiol (2020)
MeSH terms: Case Reports

Introduction. Due to the complex interaction between the underlying disease, psychosocial factors, and the high-dose hormonal therapy, transgender patients pose a therapeutic and diagnostic challenge, especially during emergencies. This case presents one such clinical dilemma using the example of a case of myocardial infarction.
Case:
A 35-year-old transgender male presented to our clinic with an acute inferior wall myocardial infarction. For the past 6 years, he was receiving high-dose testosterone therapy for the maintenance of hormone levels after female-to-male gender conversion. The emergency coronary angiography revealed a distal right coronary artery occlusion. Recanalization of the vessel was achieved by catheter-driven direct thrombectomy and subsequent intracardiac lysis. The appearance of the remaining coronary arteries bore no angiographic evidence of advanced coronary artery disease. We suspected a thromboembolic origin as the primary cause of the myocardial infarction. The presentation also fulfilled the proposed National Cerebral and Cardiovascular Center criteria for the clinical diagnosis of coronary embolism. In the diagnostic work-up, the most common causes of coronary embolism like atrial fibrillation, cardiomyopathies, endocarditis, and intracardiac tumors could be ruled out. The screening for hereditary thrombophilia was also negative. Likewise, the presence of a haemodynamically relevant right to left shunt could be excluded. In the end, the high-dose testosterone therapy seemed to be the most likely cause.
Conclusion:
Following major thromboembolic cardiovascular events, we believe that transgender males treated with high-dose testosterone therapy should receive oral anticoagulation, preferably with a DOAC, especially keeping in mind that the discontinuation of the hormone therapy is not always possible due to the various underlying psychosocial factors.
Is There a Role for Biweekly Romiplostim in the Management of Chronic Immune Thrombocytopenia (ITP)? A Report of Three Cases
Authors: Jasjit Kaur Rooprai, Karima Khamisa
Journal: Case Rep Hematol (2018)
MeSH terms: Case Reports

Romiplostim is a peptibody, which stimulates platelet production by a mechanism similar to that of endogenous thrombopoietin. It has an established indication as second-line therapy in patients with chronic immune thrombocytopenia (ITP). The agent is typically administered weekly; however, there are instances where a biweekly (i.e., alternate week) dosing may be feasible in a select group of patients. We conducted a retrospective case review to evaluate the efficacy and safety of biweekly administration of romiplostim in maintaining a platelet count of >30 × 109/L in three patients with chronic ITP. Treatment was started with a weekly injection (1 µg/kg) with a dose escalation to achieve a platelet count >30 × 109/L. Once stable on weekly romiplostim, these patients received biweekly administration. No bleeding complications were noted during biweekly dosing for these patients. The current findings suggest that lengthening the dose interval of romiplostim is feasible in select patients with chronic ITP to maintain stable platelet counts. Additional studies are therefore warranted to further evaluate biweekly dosing for romiplostim to increase convenience and decrease costs for patients with chronic ITP.
The Micro Hand S vs. da Vinci Surgical Robot-Assisted Surgery on Total Mesorectal Excision: Short-Term Outcomes Using Propensity Score Matching Analysis
Authors: Yijia Zeng, Guohui Wang, Zheng Li, Hao Lin, Shaihong Zhu, Bo Yi
Journal: Front Surg (2021)
Keywords: micro hand s surgical robot system, da vinci surgical robotic system, hospital costs, robot-assisted surgery, total mesorectum excision
MeSH terms: Case Reports

Objective: To compare the operation mode and clinical short-term outcomes of the Micro Hand S and the da Vinci surgical robot, we chose total mesorectal excision (TME) as the standard procedure for its good reflection of robot-assisted surgery advantages. Methods: We collected a total of 54 consecutive patients who underwent robot-assisted TME by two surgical robots from January 2016 to October 2020. We used propensity score matching (PSM) to create balanced cohorts of Micro Hand S group (n = 14) and da Vinci group (n = 14). Robotic installation and operation time, hospital and surgery costs, and intraoperative and postoperative clinical outcomes were compared. Results: In terms of robotic installation time, the Micro Hand S robot took longer than the da Vinci robot (24.2 ± 9.4 min vs. 17.1 ± 5.1 min, P < 0.05). As for the costs, the Micro Hand S group had lower total hospital costs (87,040.1 ± 24,676.9 yuan vs. 125,292.3 ± 17,706.7 yuan, P < 0.05) and surgery costs (25,772.3 ± 4,117.0 yuan vs. 46,940.9 ± 10,199.7 yuan, P < 0.05) than the da Vinci group. There were no statistically significant differences (P > 0.05) in other indicators, including total operation time, robotic operation time, blood loss, time to first liquid diet, time of getting out of bed, and hospital stay. Conclusion: The Micro Hand S enables patients with rectal cancer to enjoy lower medical costs of robotic surgery. Clinical Trial Registration: ClinicalTrials.gov [NCT02752698].
The Risk of Immunosuppression: A Case of Salmonella Meningitis
Authors: Joshua Dower, David P Lerner, Tamar Geva, Kenneth Wener
Journal: Case Rep Infect Dis (2018)
MeSH terms: Case Reports

Salmonella meningitis is a rare infection, particularly in adults. We report the case of a 75-year-old female with a history of rheumatoid arthritis on TNF-antagonist immunosuppressive therapy who initially presented to the hospital for management of back and leg pain and was ultimately diagnosed with bacterial meningitis secondary to Salmonella species infection. She was treated with ceftriaxone with slow improvement in neurological function. Though the source of infection was never clearly identified from multiple imaging studies, we suspect the severity of her presentation was due to her history of TNF-antagonist use.
Elizabeth Schuyler Hamilton in psychobiography: Sense of coherence and faith across her lifetime
Authors: Claude-Hélène Mayer
Journal: Front Psychol (2022)
Keywords: usa women leaders, coping, faith development theory (fdt), positive psychology (pp), sense of coherence, women in psychobiography

This article focuses on the coping skills of one selected, extraordinary woman, Elizabeth Schuyler Hamilton (1757-1854) during the founding of the United States of America. This work contributes to theory on two different levels. First, it contributes to psychobiographical research on women in diverse spheres of society, thereby strengthening the aspect of gender and coping strategies in terms of psychobiographical perspectives. Second, it contributes to theory-building in psychobiographical research anchored in positive psychology, promoting the idea that a multiplicity (crystallisation) of theories should be used to explore and analyse the lifespan of extraordinary individuals. The psychobiography responds to the question how Elizabeth Schuyler Hamilton coped with life's challenges and tragedies through the lenses of sense of coherence and faith development theory. The article uses a psychobiographical case study design within the research paradigm of modern hermeneutics. First- and third-person data on the subject were collected and evaluated through thematic analysis, including articles, documentation, letters, film material, and political scripts. Customary ethical standards for psychobiographical research were followed, thereby ensuring an ethical, respectful, empathetic and accountable research approach. The article presents findings on the coping skills, sense of coherence, and faith development in the life of Elizabeth Schuyler Hamilton which strongly influenced her resilience and support for others during her long and extraordinary life. Conclusions are drawn with regard to the way women cope in different sociocultural, sociopolitical and socio-economic spheres using historical and contemporary retrospectives. Recommendations are provided for future psychobiographical research on women in diverse contexts and in psychobiographical, gendered practice.
Transient Creatine Kinase Elevation Followed by Hypocomplementemia in a Case of Rotavirus Myositis
Authors: Yuka Rokugo, Satoru Kumaki, Ryoichi Onuma, Rie Noguchi, Saeko Suzuki, Natsuko Kusaka, Yohei Watanabe, Setsuko Kitaoka
Journal: Case Rep Pediatr (2016)

We report an infant case of rotavirus myositis, a rare complication of rotavirus infection. Complement levels of the patient were normal when serum creatine kinase (CK) level was at its peak and then decreased when the CK level became normalized. In a previous case report of rotavirus myositis, transient decrease of serum albumin, immunoglobulin, and complement levels was reported. The authors speculated that intravascular complement activation was caused by rotavirus and resulted in the pathogenesis of myositis, although complement levels at onset were not measured by the authors. In this report, however, we demonstrate that the complement activation of our patient is a result of, rather than the cause of, skeletal muscle damage.
A Case Report: Gastric Mixed Neuroendocrine-Nonneuroendocrine Neoplasm with Aggressive Neuroendocrine Component
Authors: Quang Duy Pham, Ichiro Mori, Robert Y Osamura
Journal: Case Rep Pathol (2017)
MeSH terms: Case Reports

Mixed neuroendocrine-nonneuroendocrine neoplasm (MiNEN) is defined as mixed epithelial neoplasms composed of both neuroendocrine and nonneuroendocrine components with variable proportions for each component. Neuroendocrine component can show morphological features including well- or poorly differentiated neuroendocrine neoplasms and nonneuroendocrine component can present different tumor types depending on the site of origin. Recently, studies of tumors have shown that MiNENs are not as rare as our traditional belief, due to the wide application for immunohistochemistry. However, our knowledge of MiNENs is still limited. There is no universal consensus about nomenclature, classification, and guideline of treatment. Hereby, we would like to present a case report of gastric MiNEN with aggressive neuroendocrine component to contribute a small part towards common understanding of gastric MiNENs.
Case report: ductal carcinoma in situ in the male breast
Authors: Joshua Chern, Lydia Liao, Raymond Baraldi, Elizabeth Tinney, Karen Hendershott, Pauline Germaine
Journal: Case Rep Radiol (2012)

High-grade ductal carcinoma in situ is incredibly rare in male patients. The prognosis for ductal carcinoma in situ (DCIS) in a male patient is the same as it would be for a female with the same stage disease; therefore, early recognition and diagnosis are of the utmost importance. We present a case of a male with unilateral invasive ductal carcinoma who was diagnosed with DCIS in the contralateral breast. The DCIS presented as microcalcifications on mammography and was found to be biopsy proven grade 3 papillary DCIS. This case also illustrates the importance of family history and risk factors, all of which need to be evaluated in any male presenting with a breast mass or nipple discharge.
Nonsurgical endodontic retreatment of advanced inflammatory external root resorption using mineral trioxide aggregate obturation
Authors: Shivani Utneja, Gaurav Garg, Shipra Arora, Sangeeta Talwar
Journal: Case Rep Dent (2012)

Inflammatory external root resorption is one of the major complications after traumatic dental injury. In this case report, we describe treatment of a maxillary central incisor affected by severe, perforating external root resorption. An 18-year-old patient presented with a previously traumatized, root-filled maxillary central incisor associated with pain and sinus tract. Radiographic examination revealed periradicular lesion involving pathologic resorption of the apical region of the root and lateral root surface both mesially and distally. After removal of the root canal filling, the tooth was disinfected with intracanal triple antibiotic paste for 2 weeks. The antibiotic dressing was then removed, and the entire root canal was filled with mineral trioxide aggregate. The endodontic access cavity was restored with composite resin. After 18 months, significant osseous healing of the periradicular region and lateral periodontium had occurred with arrest of external root resorption, and no clinical symptoms were apparent.
Systemic Lupus Erythematosus-Related Pancreatitis in Children: Severe and Lethal Form
Authors: R El Qadiry, A Bourrahouat, I Aitsab, M Sbihi, Y Mouaffak, F Z Moussair, S Younous
Journal: Case Rep Pediatr (2018)
MeSH terms: Case Reports

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease of unknown cause, characterized by multisystemic involvement. Its occurrence in children is rare, and acute pancreatitis is exceptional in this matter. Its diagnosis is clinical, biological, and radiological. Its treatment is based on corticosteroid therapy, and its progress is generally lethal. We report two cases of acute pancreatitis in the course of SLE, highlighting its life-threatening severity despite well-conducted treatment. Case 1: 14-year-old patient, admitted to the pediatric ICU for altered state of consciousness. This child, an outpatient since 2009 for chronic arthralgia, was hospitalized five days previously in the pediatric ward for suspicion of severe SLE, before presenting abdominal pain and vomiting. Hyperlipasemia was found, and an abdominal CT scan confirmed the diagnosis of acute pancreatitis. The patient was put under immunosuppressive therapy composed of high-dosage of corticosteroid and cyclophosphamide cures. She died 20 days after her hospitalization by severe lupus flare with multiorgan failure. Case 2: 14-year-old child, admitted to the Pediatric ward for prolonged fever associated with polyarthralgia (nondeforming, immovable, and additive) that had been progressing since 6 months with altered general state; his symptoms got worst 15 days before his hospitalization by having behavioral disorders and epigastralgia with vomiting. Pancreatitis was strongly suspected in the absence of improvement on symptomatic treatment and confirmed by hyperlipasemia 6 times the normal value and a swollen pancreas on the abdominal CT scan. The child was treated with Solumedrol and cyclophosphamide without improvement and then died after one month of hospitalization by a septic shock.
Recurrent Episodes of Thyrotoxicosis in a Man following Pregnancies of his Spouse with Hashimoto's Thyroiditis
Authors: Regina Belokovskaya, Alice C Levine
Journal: Case Rep Endocrinol (2015)

Over an 8-year period, a male patient presented three times to an endocrinologist with strikingly similar presentations, including palpitations, anxiety, and tremors. Each of his presentations occurred following either the birth of one of his two children or his wife's late termination of pregnancy. This patient's illness followed the typical time course of silent thyroiditis: hyperthyroidism, followed by euthyroidism, a late hypothyroid phase, and then a complete resolution of symptoms and normalization of thyroid function tests over a period of several months. We discuss the curious clinical presentation, diagnostic evaluation, and a literature review of alternate explanations for this patient's condition, including a discussion of the impact of seasonal shift, spousal's autoimmune disease, stress, and evolutionary changes in males postpartum. Although the differential diagnosis is broad in this case and the thyrotoxicosis could have coincidentally followed pregnancies of the patient's wife, documented hormonal changes in men during postpartum period in conjunction with the timeline of the patient's condition are suggestive of recurrent "sympathetic" postpartum thyroiditis. To our knowledge, this is the first case report of recurrent painless thyroiditis in a man following pregnancies of his wife with Hashimoto's thyroiditis.
Catheter fracture and embolization related to an arm venous port
Authors: Brent E Burbridge
Journal: Case Rep Radiol (2011)
MeSH terms: Case Reports

This 55-year-old female had a chest X-ray during a follow-up visit for the management of her breast cancer. The chest X-ray demonstrated an embolized venous catheter superimposed upon the mediastinum. It was determined that the catheter of the patient's arm port had fractured and embolized to the pulmonary circulation. The catheter was retrieved, in the interventional radiology suite, under fluoroscopic guidance. The patient suffered no ill effects. Subsequently, one day later, the old vein port was removed and a new arm port and associated catheter were implanted to facilitate the delivery of the patient's ongoing chemotherapy.