OpenMed/multicare-articles huggingface dataset:
Case Report: Three-dimensional printed prosthesis reconstruction for patello-femoral large osteochondral defects in a patient with distal femoral giant cell tumour: A case report
Authors: Dechao Yuan, Xiang Fang, Senlin Lei, Nishant Banskota, Fuguo Kuang, Yawei Gou, Wenli Zhang, Hong Duan
Journal: Front Bioeng Biotechnol (2022)
Keywords: distal femoral, giant cell tumour, osteochondral defects, osteochondral reconstruction, patello-femoral, three-dimensional printed prosthesis
MeSH terms: Case Reports

Background: The restoration and reconstruction of patello-femoral large osteochondral defects caused by bone tumours are challenging because of the local recurrence rate and the joint's mechanical complexity. Although three-dimensional (3D)-printed prostheses are commonly adopted for tumour-induced bone defect reconstruction, patello-femoral osteochondral reconstruction with 3D-printed prostheses is rarely reported. Case presentation: A 44-year-old female patient with progressive swelling and pain in the left knee for 6 months was diagnosed with Campanacci Grade II giant cell tumour (GCT). She underwent intralesional curettage combined with autografting and internal fixation, after which complications of deep infection arose. The patient then underwent internal fixation removal and cement packing. Afterwards, the pain of the affected knee persisted for 11 months, and bone cement removal plus 3D-printed modular prosthesis reconstruction was performed. At the last follow-up 27 months after surgery, she was pain free, the Musculoskeletal Tumour Society (MSTS) score improved from 15/30 to 29/30, the Visual Analogue Scale (VAS) score decreased from 7 to 0, and knee flexion increased from 50° to 130°. X-ray images 22 months after surgery showed that the prosthesis and screws were in a stable position, and callus formation was found at the prosthesis-bone interface. Conclusions: A 3D-printed modular prosthesis may be a useful treatment option for the surgical reconstruction of GCT-induced patello-femoral large osteochondral defects. The firm fixation, osseointegration, and favourable congruency of the 3D-printed prosthesis with the adjacent articular surface can achieve long-term knee function and stability.
Posttraumatic atlantoaxial rotatory dislocation in a healthy adult patient: a case report and review of the literature
Authors: Giuseppe Maida, Eleonora Marcati, Silvio Sarubbo
Journal: Case Rep Orthop (2012)

Atlantoaxial rotatory dislocation (AARD) is a rare complication in adults usually leading to pain, spinal cord injury, or death. Clinical and radiological diagnosis is difficult and often delayed. We report a rare case of posttraumatic AARD in a neurological intact 27-year-old male in which initial radiographic evaluation was negative. A computed tomography (CT) scan was promptly done because the patient showed a severe torticollis. Therefore, early diagnosis, immobilisation, and surgical fusion and arthrodesis were performed. After surgery, cervical pain and torticollis were resolved and the patient remained neurologically intact with a CT scan documentation of fusion at the 3-year followup.
Systemic Bartonella henselae Infection in Immunocompetent Adult Presenting as Fever of Unknown Origin
Authors: Thierry Zenone
Journal: Case Rep Med (2011)
MeSH terms: Case Reports

Systemic clinical presentations of infection caused by Bartonella henselae are rare in immunocompetent adults. We report four cases with hepatic and/or splenic involvement, presenting as fever of unknown origin. We discuss diagnosis and treatment of this infection. Bartonella henselae serology allows an easy diagnosis of hepatosplenic involvement in cat scratch disease, a clinical picture that appears to be underrecognized.
Case Report: Positive Pressure Therapy Combined With Endolymphatic sac Surgery in a Patient With Ménière's Disease
Authors: Munehisa Fukushima, Shiro Akahani, Hidenori Inohara, Noriaki Takeda
Journal: Front Surg (2021)
Keywords: ménière's disease, endolymphatic hydrops, endolymphatic sac surgery, magnetic resonance imaging, positive pressure therapy
MeSH terms: Case Reports

Positive pressure therapy (PPT) is applied for medically-intractable vertigo in Ménière's disease (MD); however, it remains unknown whether PPT affects in vivo endolymphatic hydrops (EH). In this case report, we describe a 5-year course of MD in a patient in which EH was repeatedly observed. As the patient experienced recurrent vertigo attacks after endolymphatic sac surgery, he began to use the PPT device additionally and vertiginous episodes decreased in accordance with a decrease in the EH volume. The mechanism of PPT is suggested that the pressure increase in the middle ear inhibits EH development. PPT, if added after surgery, might be more effective to reduce EH volume compared with surgery alone. A larger study group size is required to test these preliminary data concerning EH changes.
Implementation of a vaccine against Shigatoxin 2e in a piglet producing farm with problems of Oedema disease: case study
Authors: Regine Fricke, Olaf Bastert, Verena Gotter, Nico Brons, Johan Kamp, Hans-Joachim Selbitz
Journal: Porcine Health Manag (2015)
Keywords: edec, oedema disease, reduction of antimicrobial use, stec, shigatoxin 2e, vaccine

Oedema disease is one of the major diseases in pigs during the nursery period. It is caused by Shigatoxin 2e producing strains of Escherichia coli. In order to combat the disease, the metaphylactic use of colistin sulphate and zinc oxide is widely spread. Additionally, special feeding regimens such as the reduction of the amount of crude protein and the increase of the amount of crude fibre are applied. The goal of this study was to test the efficacy of a vaccine against Oedema disease caused by Shigatoxin 2e in a field trial on a farm with a history of Oedema disease in nursery pigs. The study was carried out on a Dutch farm with 600 sows and a one-week farrowing rhythm and lasted for the time of one year. During this time all piglets were vaccinated with 1 ml ECOPORC SHIGA at the average age of 4 days. The parameters Overall mortality, use of antimicrobials in general, calculated as defined daily dose per animal, use of colistin sulphate and the weight gain were evaluated for all nursery pigs and compared to historical data of animals from the same period of time directly prior to the study serving as a historical control group. The previous mortality in the nursery of 7.7% was significantly reduced to 1.3% after vaccination. The metaphylactic use of colistin sulphate during the nursery period was stopped during the study because no deaths due to Oedema disease had occurred anymore after beginning of vaccination. The defined daily dose per animal per month was significantly reduced from a mean of 1.050 in the year 2012 to a mean of 0.215 in the year 2013. The defined daily dose per animal per year was therefore relevantly reduced from 12.6 in 2012 to 2.6 in 2013. These results show that on this farm Oedema disease can not only be controlled successfully by vaccination but also that vaccination can significantly reduce the use of antimicrobials in the nursery period.
Neurostimulation as an Efficacious Nonpharmacologic Analgesic following Arthroscopic Rotator Cuff Repair
Authors: Ryan B Juncker, Joel J Gagnier, Faisal M Mirza
Journal: Case Rep Anesthesiol (2022)
MeSH terms: Case Reports

This case highlights the importance of pursuing nonpharmacologic analgesic modalities in orthopedic surgery to combat the current opioid epidemic. Presented is a patient who underwent an arthroscopic rotator cuff repair and biceps tenodesis operation and through the use of neurostimulation (in the form of auricular electrostimulation), fully recovered from surgery without the usage of any opioid or nonsteroidal anti-inflammatory medications. The patient was fitted with a novel auricular electrostimulation device (DyAnsys Primary Relief) in the immediate postoperative period that provided constant neurostimulation for 10 days, this neurostimulator was the only analgesic modality used in this case, and the patient reported minimal postoperative pain. The utility of this case centers around the lack of postoperative opioid use, presenting the idea that postsurgical orthopedic pain can be managed in a nonpharmacologic capacity, combatting the fields' ongoing opioid epidemic.
What is the treatment of tracheal lesions associated with traditional thyroidectomy? Case report and systematic review
Authors: Nicola Tartaglia, Roberta Iadarola, Alessandra Di Lascia, Pasquale Cianci, Alberto Fersini, Antonio Ambrosi
Journal: World J Emerg Surg (2018)
Keywords: total thyroidectomy, tracheal injury, tracheal laceration, tracheal lesion, tracheal surgery, tracheostomy
MeSH terms: Postoperative Complications / therapy, Thyroidectomy / standards, Case Reports, Review, Systematic Review, Adult, Female, Humans, Retrospective Studies, Risk Factors, Trachea / injuries, Trachea / surgery, Tracheal Diseases / diagnosis

Aim:
The aim of this study is to review the literature focusing on various treatments based on time of tracheal injury and on different surgeons' personal experience.
Methods:
We retrospectively reviewed all cases of total thyroidectomy performed at the University Surgical Department of Ospedali Riuniti of Foggia from 2006 to 2017. Only a single case of tracheal lesion due to traditional total thyroidectomy was found. An extensive search of the relevant literature was carried out using MEDLINE (PubMed). We included articles that reported article type, patient number, sex, age, reasons for surgery, time of tracheal perforation intraoperatively or delayed rupture, symptoms, diagnosis, type of surgical procedure, pathological report and follow-up.
Results:
A total of 156 published studies were screened from the sources listed. Of these, 15 studies were included in the present study. We introduced our case in the analysis. A total of 16 patients were totally analysed. There were seven males (43.7%) and seven females (43.7%), and for two patients, gender was not available. The mean patient age was 41.6 years.
Conclusions:
The literature review showed very few cases treated differently. However, it would be good to standardise treatments. Tracheal perforation, if encountered, needs to be managed appropriately in centres of expertise with a high volume of thyroidectomies.
Differentiation of sarcoidosis-lymphoma syndrome lesions: a case report on the use of two different positron emission tomography tracers
Authors: Ryan Yudistiro, Yukiko Arisaka, Azusa Tokue, Takahito Nakajima
Journal: BMC Med Imaging (2016)
MeSH terms: Lymphoma / diagnosis, Multimodal Imaging / methods, Positron-Emission Tomography / methods, Sarcoidosis / diagnosis, Tomography, X-Ray Computed / methods, Case Reports, Diagnosis, Differential, Female, Fluorodeoxyglucose F18 / metabolism, Humans, Lung / pathology, Mediastinum / pathology, Middle Aged, Radiopharmaceuticals / metabolism, alpha-Methyltyrosine / metabolism, Radiopharmaceuticals, Fluorodeoxyglucose F18, alpha-Methyltyrosine

Background:
Sarcoidosis-lymphoma syndrome (SLS) is a rare disease in which both entities coexist. We aimed to study the role of (18)F-fluorodeoxyglucose (FDG) and L-[3-(18)F] α-methyltyrosine (FAMT) positron emission tomography (PET)/computed tomography (CT) in differentiating between these two lesions.
Case presentation:
A 54-year-old female with large liver tumors was referred to our Nuclear Medicine Department for staging using FDG PET/CT. She had a history of primary biliary cirrhosis (PBC) for 15 years and developed lung and mediastinal sarcoidosis 1 year before the liver tumors were noted. Abdominal dynamic CT revealed two well-circumscribed, peripherally-enhancing, low-density masses in the right lobe of the liver with intensive ring-form FDG uptakes at maximum standard uptake values (SUVmax) of 18.3 and 19.5, respectively. In the arterial phase, a hepatic artery was seen penetrating the tumor, a phenomenon known as "angiogram sign". Chest PET/CT findings showed irregular thickening of the bronchovascular bundles, central peribronchial shaggy consolidations in the right middle and lower lobes (SUVmax, 4.6), and mediastinal and hilar lymphadenopathies (SUVmax, 2.7). After assessment, chemotherapy with rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone (R-CHOP) was administered for eight cycles. Follow-up imaging studies using FDG and FAMT PET/CT were performed 3 months after the last cycle of chemotherapy, which showed that the two highly FDG-avid tumors in the liver had disappeared. However, faint FDG uptake persisted in the lung consolidations (SUVmax, 6.3), and FDG uptake for the mediastinal lymphadenopathies increased (SUVmax of 5.8). In contrast, there was no significant uptake of FAMT in the liver, as well as in the lungs and the bilateral mediastinal lymphadenopathies. These discrepant uptakes between FDG and FAMT were compatible with sarcoidosis.
Conclusion:
Combination of FDG and FAMT in PET/CT studies may play an important role in the management of SLS patients, especially in differentiating between sarcoidosis and lymphoma lesions.
Holoprosencephaly in an Egyptian baby with ectrodactyly-ectodermal dysplasia-cleft syndrome: a case report
Authors: Kotb Abbass Metwalley Kalil, Hekma Saad Fargalley
Journal: J Med Case Rep (2012)

Introduction:
Ectrodactyly-ectodermal dysplasia-cleft lip or palate syndrome (OMIM No. 129900) is characterized by the triad of ectrodactyly, ectodermal dysplasia and facial clefting (of the lip and/or palate). Holoprosencephaly denotes a failure in the division of the embryonic forebrain (prosencephalon) into distinct lateral cerebral hemisphere. The association between ectrodactyly-ectodermal dysplasia-cleft lip or palate syndrome and holoprosencephaly is very rare. Here we report holoprosencephaly in an Egyptian infant with ectrodactyly-ectodermal dysplasia-cleft lip or palate syndrome.
Case presentation:
An 11-month-old Egyptian female baby was referred to our institution for an evaluation of poor growth; the pregnancy and perinatal history were uneventful. On examination, her growth parameters were below the third centile, she had bilateral ectrodactyly of both hands and feet, dry rough skin, sparse hair of the scalp and operated right cleft lip and cleft palate. Computerized tomography of her brain revealed holoprosencephaly.
Conclusion:
The importance of the early diagnosis of this syndrome should be emphasized in order to implement a multidisciplinary approach for proper management of such cases.
A Case of Iatrogenic Cushing's Syndrome following Use of an Over-the-Counter Arthritis Supplement
Authors: Colin Dunn, Joshua Amaya, Patrick Green
Journal: Case Rep Endocrinol (2023)
MeSH terms: Case Reports

Background:
Iatrogenic Cushing's syndrome is commonly seen as a complication of chronic steroid use. While most often associated with the use of prescription oral steroids, rare cases result from unintentional steroid exposure. In particular, numerous complementary and alternative medicines have been found to contain steroids not previously known to users. Case Presentation. Here, we present a case of iatrogenic Cushing's syndrome caused by prolonged ingestion of dexamethasone found within an over-the-counter arthritis supplement called Artri King.
Conclusion:
A thorough history of medication use to include over-the-counter medications and supplements may be required to identify the source of exogenous glucocorticoids in iatrogenic Cushing's syndrome.
Case Report: Olaparib Shows Satisfactory Clinical Outcomes Against Small Cell Esophageal Carcinoma With ATM Mutation
Authors: Weiwei Wang, Xiaoyan Zhang, Yu Fang, Jia He, Jingjing Huang, Shanqing Li, Tonghui Ma, Li Li
Journal: Front Oncol (2022)
Keywords: atm mutation, parp inhibitor, scec, case report, olaparib
MeSH terms: Case Reports

Small cell esophageal carcinoma (SCEC) is a rare, undifferential type of cancer, with a high degree of malignancy and early systemic metastasis. Radio-chemotherapy and surgery have been used as the primary treatment strategies for SCEC, but they both result in poor prognosis. There is need to develop an optimal standard treatment for the disease to improve prognosis and limit the related mortality. In this study, we described identification of driver mutations in ATM, a gene involved in homologous recombination deficiency (HRD) pathway, using next-generation sequencing on primary lesion and peripheral blood of a SCEC patient, who experienced recurrence after resection and radio-chemotherapy. In addition, we subjected the patient to olaparib, a PARP inhibitor, for the treatment of tumor with HRD and obtained a partial response. This is the first evidence implicating olaparib in successful treatment of SCEC with ATM mutation. The findings suggest that targeting mutations in HRD genes using olaparib or actionable genetic mutations using corresponding drugs, may be an effective therapeutic option for SCEC, although this requires further investigation.
Lymphocytic colitis presenting as difficult diarrhoea in an African woman: a case report and review of the literature
Authors: Udeme E Ekrikpo, Jesse A Otegbayo, Abideen O Oluwasola
Journal: J Med Case Rep (2010)

Introduction:
Lymphocytic colitis is an uncommon intestinal disorder that presents with chronic diarrhoea. It is treatable, but in the developing world, its diagnosis may often prove difficult. Data and reports of this condition in Africa are scarce because most medical centres lack a functional gastrointestinal endoscopy unit that would aid in the diagnosis.
Case presentation:
We present the case of a 53-year-old Nigerian woman with pathogen-negative chronic diarrhoea and a family history of chronic diarrhoea. She responded well to treatment after colonoscopy and colonic biopsy successfully diagnosed her illness.
Conclusion:
Referral of patients with pathogen-negative chronic diarrhoea to medical centres that have facilities for colonoscopy and biopsy is important in the developing world.
Clinico-radiological evaluation and management of type II radial ray defect in a young female from rural India: case report
Authors: Anshul Sood, Rajasbala Pradeep Dhande, Vadlamudi Nagendra, Gaurav Mishra, Gopidi Nidhi Reddy
Journal: Pan Afr Med J (2022)
Keywords: radial ray defect, case report, radial dysplasia, radial ray anomaly
MeSH terms: Quality of Life, Radius / abnormalities, Radius / diagnostic imaging, Radius / surgery, Case Reports, Adolescent, Child, Preschool, Female, Forearm, Hand, Humans, Paresthesia, Pregnancy

Radial Ray Defect (RRD) is a rare disorder, and the etiology of this disorder is still under discussion. RRD is associated with many medical conditions for which prenatal counselling is of paramount importance. Any association with the family history is still unknown. The patient is a 16-year-old female who came to the orthopaedic clinic complaining of tingling and weakness in the right forearm. On examination, there was a gross deformity in the right forearm with radial deviation of the hand. An X-ray revealed radial ray defect type-2. She previously had a history of perinatal infection during early childhood. Surgery was successfully achieved, and positive results were accomplished. Radial Ray Defect can be focal or associated with other clinical manifestations. The timing of antenatal ultrasound for detecting this musculoskeletal anomaly is crucial. When RRD is associated with other syndromes, counselling to the parents about the quality of life and morbidity comes into play. Treatment is primarily surgical.
Guanfacine monotherapy for ADHD/ASD comorbid with Tourette syndrome: a case report
Authors: Kosuke Okazaki, Kazuhiko Yamamuro, Junzo Iida, Toshifumi Kishimoto
Journal: Ann Gen Psychiatry (2019)
Keywords: atomoxetine, attention deficit/hyperactivity disorder, autism spectrum disorder, guanfacine, methylphenidate, tourette syndrome
MeSH terms: Case Reports

Background:
Patients with attention deficit/hyperactivity disorder (ADHD) often experience comorbid conditions, such as autism spectrum disorder (ASD) and Tourette syndrome (TS). Although pharmacotherapies are effective for treating ADHD, they are likely to elicit a variety of adverse effects. It is, thus, important to select an effective and well-tolerated pharmacotherapeutic treatment for patients with ADHD/ASD comorbid with TS.
Case presentation:
We report the case of a 10-year-old boy with ADHD/ASD comorbid with TS who was treated with guanfacine (GUAN). He experienced several side effects of atomoxetine (ATX) and methylphenidate (MPH) before being treated with GUAN. In the presented case, symptoms of ADHD as well as tic symptoms were improved by treatment with GUAN.
Conclusion:
GUAN might be effective and well tolerated in the treatment of patients with ADHD/ASD comorbid with TS who experience side effects of ATX and MPH.
Dermal and neural toxicity caused by acrylamide exposure in two Korean grouting workers: a case report
Authors: Heeyun Kim, Sang Gil Lee, Jeongbae Rhie
Journal: Ann Occup Environ Med (2017)
Keywords: acrylamide, cerebellar ataxia, dermatitis, grouting agent, korea, neuropathy
MeSH terms: Case Reports

Background:
Peripheral neuritis caused by acrylamide is well-known, and many Korean grouting workers are frequently exposed to acrylamide in grouting agents that are injected into cracked concrete. We recently encountered two cases of dermal and neural toxicity in Korean grouting workers with exposure to grouting agents that contained a high concentration of acrylamide.
Case presentation:
The first case involved a 44-year-old man with 8 years of waterproofing experience. The patient developed peeling skin on both hands while grouting, which progressed to systemic neurological symptoms, such as reduced sensory function and strength. The patient was diagnosed with peripheral neuropathy caused by acrylamide exposure, and fully recovered after conservative treatment and withdrawal of exposure to the grouting agent. The second case involved a 34-year-old man with 10 years of grouting experience. The patient initially experienced weakness in both legs, which progressed to weakness in his arms and uncontrolled phonation. After being hospitalized, he was diagnosed with cerebellar ataxia and peripheral neuropathy caused by acrylamide exposure, and was discharged after conservative treatment. Our follow-up investigation revealed that both workers were recently exposed to grouting agents that contained higher concentrations of acrylamide, compared to the agents that they had previously been using.
Conclusions:
Both workers had workplace acrylamide exposure through dermal contact plus inhalation of dust and vapor, which led to the neural toxicity and dermatitis. Therefore, government studies are needed to investigate the current status of workplace acrylamide use, and to protect workers from the hazardous effects of using acrylamide-containing grouting agents.
Osteosarcoma of the rib
Authors: Wy Lim, S Ahmad Sarji, Yi Yik, Tm Ramanujam
Journal: Biomed Imaging Interv J (2008)
Keywords: osteosarcoma, rib
MeSH terms: Case Reports

This case describes the radiological-surgical correlation of a rare case of osteosarcoma of the rib in a 15-year-old boy. Successful repair of his chest wall defect using a wire mesh following extensive surgical resection of the tumour is highlighted, such a procedure being the first instituted at our centre.