OpenMed/multicare-articles huggingface dataset:
Yersinia enterocolitica Prosthetic Joint Septic Arthritis Successfully Treated with Ceftriaxone
Authors: Hafez M Abdullah, Mansi Oberoi, Abdelmohaymin Abdalla, Smitha Narayana Gowda, Moataz Ellithi
Journal: Case Rep Infect Dis (2021)
MeSH terms: Case Reports

Yersinia enterocolitica is a Gram-negative coccobacillus that is known to cause gastroenteritis and symptoms mimicking appendicitis or terminal ileitis. It is also one of the culprit infections implicated in causing reactive arthritis. Rarely, it can cause musculoskeletal infections including osteomyelitis, septic arthritis, and discitis. We describe the case of a 70-year-old female with multiple comorbidities who presented with left knee pain and swelling after recent gastroenteritis. She was found to have Yersinia enterocolitica septic arthritis in her left knee prosthetic joint. The patient underwent an exchange of her prosthetic material and was successfully treated with a six-week course of ceftriaxone. Our article aims to highlight a rare manifestation of Yersinia enterocolitica infection and to point out an important differential for reactive arthritis after Yersinia enterocolitica infection.
Case Reports of Cow's Milk Protein Allergy Presenting as Delayed Passage of Meconium With Early Onset Infant Constipation
Authors: Akshita Madala, Allison C Lure, Svea Cheng, Sam X Cheng
Journal: Front Pediatr (2022)
Keywords: cow's milk protein allergy, cow's milk protein sensitivity, delayed meconium passage, early onset infant constipation, milk allergy
MeSH terms: Case Reports

A cellular proliferation to milk allergens has been found in the cord blood cells of neonates. While this reflects a sensitivity during the fetal life, its clinical significance and disease, particularly its unconventional presentations, have remained largely unrecognized by care providers. Here, we report three cases of infants whose mothers consumed dairy products during pregnancy, who developed a severely constipated pre- and postnatal bowel. The passage of meconium was significantly delayed with subsequent early-onset infant constipation that was intractable to conventional therapies but remitted when milk proteins were withheld, recurred when milk proteins were reintroduced, and resolved again when switched to an extensively hydrolyzed or amino acid-based infant formula. Based on this and other observations, it is believed that these infants must have initiated and/or developed cow's milk protein allergy prenatally during fetal life. We suggest that a 2-week trial of cow's milk protein avoidance be applied to these neonate infants with early-onset constipation before an unnecessary invasive work-up for Hirschsprung disease and others is initiated per the current guidelines.
Case Report: Pediatric Malignant Atrophic Papulosis With Small Bowel Perforation and Positivity of Anticardiolipin Antibody
Authors: Hai-Qing Wang, Yu Guan, Xiao-Pan Gong, You-Tao Chen, Chao Ji
Journal: Front Pediatr (2021)
Keywords: degos disease, anticardiolipin antibody, bowel perforation, malignant atrophic papulosis, pediatric
MeSH terms: Case Reports

Malignant atrophic papulosis (MAP) is a life-threatening vasculopathy affecting the skin, gastrointestinal tract, central nervous system, pleural membrane, and pericardium. MAP carries a poor prognosis primarily because of its systemic involvement. It is extremely rare in children. Herein, we report a pediatric case of MAP with small bowel perforation and anticardiolipin antibody positivity.
Newly developed fully covered metal stent for unresectable malignant biliary stricture
Authors: Kei Ito, Naotaka Fujita, Yutaka Noda, Go Kobayashi, Takashi Obana, Jun Horaguchi, Shinsuke Koshita, Yoshihide Kanno, Takahisa Ogawa, Yuhei Kato, Yasunobu Yamashita
Journal: Diagn Ther Endosc (2010)
MeSH terms: Case Reports

We herein report two patients with unresectable malignant biliary stricture who underwent stenting with a newly developed fully-covered metal stent. In the first case of lower-middle bile duct cancer, a stent was placed through the stenosis. In the second case of middle bile duct stricture due to lymph node metastases from gallbladder cancer, a stent was placed in the bile duct across the stenosis. No procedure-related complications were observed. Unevenness of the outer surface and a low shortening ratio are expected to lessen the occurrence of complications characteristic of covered metal stents such as stent migration and bile duct kinking.
Pneumocephalus and Meningitis as Complications of Mastoiditis
Authors: Conor Barry, George Rahmani, Diane Bergin
Journal: Case Rep Radiol (2019)
MeSH terms: Case Reports

Pneumocephalus in the absence of trauma, tumour, or surgery is a rare entity. We report a case of a 73-year-old lady who presented with sepsis leading to confusion and unresponsiveness. A CT of brain revealed mastoiditis, sinusitis, and associated pneumocephalus. Further investigations led to an eventual diagnosis of pneumococcal meningitis. The combination of pneumocephalus and meningitis as complications of mastoiditis is rare with very few cases published in the literature. We describe one such case.
Brugada ECG pattern precipitated by acute pneumonia: a case report
Authors: Salaheldin Abusin
Journal: Cases J (2009)

Brugada type 1 ECG pattern is the hallmark for the diagnosis of Brugada syndrome which is a cause of sudden death due to ventricular arrhythmias. We present a case of a previously healthy young man who was admitted with productive cough with greenish phlegm and right-sided chest pain which was subsequently diagnosed as acute pneumonia. A routine ECG was done as part of his evaluation and showed Brugada ECG type 1 pattern. He was treated with antibiotics and on follow up his ECG was normal. In this report we present this increasingly described phenomenon and briefly review the literature.
Single-Incision Laparoscopic Liver Resection for Colorectal Metastasis through Stoma Site at Time of Reversal of Diversion Ileostomy: A Case Report
Authors: Bård I Røsok, Bjørn Edwin
Journal: Minim Invasive Surg (2011)
MeSH terms: Case Reports

Minimally invasive surgical techniques for liver tumors are gaining increased acceptance as an alternative to traditional resections by laparotomy. In this article we describe a laparoscopic liver resection of a metastatic lesion in a patient primarily operated for colorectal cancer. The resection was conducted as a single port procedure through the stoma aperture at time of reversal of the diversion ileostomy. Sigle incision liver resections may be less traumatic than conventional laparoscopy and could be applied in selected patients with both benign and malignant liver tumors.
Acute Myelogenous Leukemia With Trisomy 8 and Concomitant Acquired Factor VII Deficiency
Authors: Leila Moosavi, Jonathan Bowen, Jeffrey Coleman, Arash Heidari, Everardo Cobos
Journal: J Investig Med High Impact Case Rep (2019)
Keywords: acute myelogenous leukemia, cytogenetic abnormality, factor vii deficiency, trisomy 8, vitamin k
MeSH terms: Factor VII Deficiency / etiology, Leukemia, Myeloid, Acute / complications, Trisomy / pathology, Case Reports, Adult, Antineoplastic Agents / therapeutic use, Chromosomes, Human, Pair 8, Factor VII Deficiency / blood, Factor VII Deficiency / genetics, Female, Humans, Leukemia, Myeloid, Acute / blood, Leukemia, Myeloid, Acute / drug therapy, Leukemia, Myeloid, Acute / genetics, Antineoplastic Agents, Chromosome 8, trisomy

Acquired isolated factor VII deficiency is a rare bleeding disorder and has been reported in 31 cases. This is in contrast to congenital factor VII deficiency, which while also infrequent is the most common rare congenital bleeding disorder. Acquired isolated factor VII deficiency has been described primarily in patients with solid malignancies, sepsis, and in the presence of anti-factor VII autoantibodies. We report a case of acute myelogenous leukemia with an associated trisomy 8 cytogenetic abnormality presenting with factor VII deficiency. The factor VII deficiency cleared after induction chemotherapy and with the disappearance of the cytogenetic and molecular abnormalities. We discuss a possible link between trisomy 8 and vitamin K metabolism, which might result in acquired factor VII deficiency in acute myelogenous leukemia.
Wandering Spleen and Organoaxial Gastric Volvulus after Morgagni Hernia Repair: A Case Report and Review of the Literature
Authors: Noemi Cantone, Caterina Gulia, Vittorio Miele, Margherita Trinci, Vito Briganti
Journal: Case Rep Surg (2016)

Wandering spleen and gastric volvulus are two rare entities that have been described in association with congenital diaphragmatic hernia. The diagnosis is difficult and any delay can result in ischemia and necrosis of both organs. We present a case of a 13-year-old girl, previously operated on for anterior diaphragmatic hernia and intrathoracic gastric volvulus, that presented to our service for a subdiaphragmatic gastric volvulus recurrence associated with a wandering spleen. In this report we reviewed the literature, analyzing the clinical presentation, diagnostic assessment, and treatment options of both conditions, in particular in the case associated with diaphragmatic hernia.
Impact of FMR1 Premutation on Neurobehavior and Bioenergetics in Young Monozygotic Twins
Authors: Eleonora Napoli, Andrea Schneider, Randi Hagerman, Gyu Song, Sarah Wong, Flora Tassone, Cecilia Giulivi
Journal: Front Genet (2018)
Keywords: fxtas, bioenergetics, mitochondrial dysfunction, oxidative stress, premutation

Mitochondrial dysfunction (MD) has been identified in lymphocytes, fibroblasts and brain samples from adults carrying a 55-200 CGG expansion in the fragile X mental retardation 1 (FMR1) gene (premutation; PM); however, limited data are available on the bioenergetics of pediatric carriers. Here we discuss a case report of three PM carriers: two monozygotic twins (aged 8 years) harboring an FMR1 allele with 150-180 CGG repeats, with no cognitive or intellectual issues but diagnosed with depression, mood instability and ADHD, and their mother (asymptomatic carrier with 78 CGG repeats). Fibroblasts and lymphocytes from the twins presented a generalized OXPHOS deficit, altered mitochondrial network, accumulation of depolarized mitochondria, and increased mitochondrial ROS production, outcomes distinct and more severe than the mother's ones, suggesting the involvement of modulatory effects mediated by CGG expansion, X-activation ratio, sex hormones and epigenetic factors (chronic inflammation, consequence of Lyme disease). The degree of the severity of MD appeared to segregate with the morbidity of the phenotype. The mitochondrial ROS-mediated HIF-1α stabilization was identified as a key player at contributing to the MD, pointing it as a novel target for future therapeutical intervention.
A Case of Prepubertal Ovarian Tissue Cryopreservation in Metachronous Bilateral Mature Ovarian Teratoma Requiring Bilateral Oophorectomy
Authors: Tom Malik, Robert Wheeler, Nigel J Hall, Juliet Gray
Journal: European J Pediatr Surg Rep (2022)
Keywords: dermoid cyst, fertility, mature teratoma, ovarian tissue cryopreservation, ovarian tumor
MeSH terms: Case Reports

Mature ovarian teratoma has the potential to occur metachronously in the contralateral ovary. There are significant implications for fertility as bilateral oophorectomy may be indicated. In prepubertal girls, ovarian tissue cryopreservation (OTC) offers the only possibility of a future biological pregnancy but outcome data are limited. We present a case of prepubertal OTC in a 12-year-old girl undergoing a second oophorectomy for metachronous contralateral mature teratoma. We offer a discussion of the challenges that emerged regarding perioperative decision-making, balancing the need for safe oncological resection with the desire to preserve fertility.
A Case of Medialized Lateral Maxillary Sinus Wall: A Pillar of Support
Authors: I A Othman, N D Hashim, A J Nazimi
Journal: Case Rep Med (2018)
MeSH terms: Case Reports

The number of maxillofacial trauma (MFT) cases attended in the Emergency Department is progressively increasing in trend, owing to the rising statistics of motor-vehicle accidents (MVAs) and urban assaults in addition to occupational-related injuries. Prompt and thorough assessment is important for accurate diagnosis and paramount treatment plans. We will be discussing a case of unusual presentation of an orbital floor fracture post-MVA which was treated conservatively based on the clinical assessments during follow-ups, supported by radiological findings. We will also briefly discuss the different radiological modalities available in assessing MFT and late presentation of enophthalmos.
Successful management of recalcitrant fungal keratitis with topical caspofungin
Authors: Siddhi Goel, Arpit Sharma, Rajesh Sinha
Journal: GMS Ophthalmol Cases (2022)
Keywords: caspofungin, corneal ulcer healing, echinocandins, fungal corneal ulcer, recalcitrant fungal keratitis
MeSH terms: Case Reports

Objective:
To report a case of recalcitrant fungal keratitis successfully managed with topical caspofungin acetate in North India.
Methods:
Case report and literature review.
Results:
An 18-year-old male patient presented with complaints of redness, watering, pain and diminution of vision in the right eye and was referred to our centre as a case of corneal ulcer. The patient was examined and found to have a near total epithelial defect, with corneal infiltrates approximately 8x8 mm. A provisional diagnosis of polymicrobial keratitis was made based on corneal scraping suggestive of S tap h ylococcus aureus and confocal scan revealing fungal hyphae. The patient failed to respond to topical voriconazole 1%, natamycin 5% and moxifloxacin hydrochloride 0.5% with oral voriconazole. In view of the poor response to these drugs, the patient was subsequently administered topical caspofungin 0.5% in place of natamycin and continued on topical and oral voriconazole, in addition to topical moxifloxacin and cycloplegics, which finally led to healing with minimal scarring. The patient attained a best corrected visual acuity (BCVA) of 6/12.
Conclusion:
Topical caspofungin may be used as a useful and effective alternative in cases of recalcitrant fungal keratitis. It may result in healing with minimal scarring.
Interdisciplinary complication management of dislodged lumbar interbody spacer in pulmonary artery
Authors: Andreas Kunz, Thorsten Klink, Stefan Köhler, Richard Kellersmann, Christian Markus, Thorsten Bley, Ralph Kickuth
Journal: BJR Case Rep (2017)
MeSH terms: Case Reports

We report the case of an intraoperatively dislodged transforaminal lumbar interbody fusion spacer with creation of a traumatic arteriovenous fistula and device migration to the pulmonary artery. Successful minimally invasive angiographic retrieval of the spacer is discussed with special reference to angiographic and surgical treatment strategies and pitfalls.
Thrombotic Microangiopathy and Acute Kidney Injury Induced After Intravitreal Injection of Vascular Endothelial Growth Factor Inhibitors VEGF Blockade-Related TMA After Intravitreal Use
Authors: Ramy M Hanna, Ngoc-Tram Tran, Sapna S Patel, Jean Hou, Kenar D Jhaveri, Rushang Parikh, Umut Selamet, Lena Ghobry, Olivia Wassef, Marina Barsoum, Vanesa Bijol, Kamyar Kalantar-Zadeh, Alex Pai, Alpesh Amin, Baruch Kupperman, Ira B Kurtz
Journal: Front Med (Lausanne) (2020)
Keywords: aflibercept (eylea), bevacizumab (avastin), diabetic retinopathy, intravitreal injections, ranibizumab (lucentis), thrombotic microangiopathy, vascular endothelial growth factor (vegf)

Vascular endothelial growth factor (VEGF) inhibition can cause worsening hypertension, proteinuria, chronic kidney injury, and glomerular disease. Thrombotic microangiopathy (TMA) and other nephrotic disorders have been reported with systemic VEGF blockade. These same agents are given intravitreally for age-related macular degeneration (AMD) and diabetic retinopathy (DR), albeit at lower doses than those given for systemic indications. Systemic absorption of anti-VEGF agents when given intravitreally has been shown consistently along with evidence of significant intravascular VEGF suppression. While worsening hypertension has only been seen in some large-scale studies, case reports show worsening proteinuria and diverse glomerular diseases. These include TMA-associated lesions like focal and segmental glomerulosclerosis with collapsing features (cFSGS). In this paper, we report three cases of TMA likely associated with the use of intravitreal anti-VEGF therapy. These patients developed the signature lesion of VEGF blockade in a 6 to 11 month time frame after starting intravitreal VEGF inhibitors. The literature is reviewed showing similar cases. Intravitreal VEGF blockade may cause these adverse events in a hitherto unidentified subgroup of patients. Well-controlled prospective observational trials are needed to determine the event rate and identify which subgroups of patients are at increased risk. A registry for patients who develop worsening hypertension, proteinuria exacerbation, and glomerular diseases from intravitreal VEGF blockade is proposed.
Acute Inflammatory Pericarditis following First Dose of COVID-19 Vaccine (AstraZeneca)
Authors: Mohammed Alshaikh, Abdullah Muharib, Radhi Alshehri, Abdulaziz Alshoaibi, Mohammed Qattea, Shahad AlOtaiby
Journal: Case Rep Cardiol (2022)
MeSH terms: Case Reports

Background:
Clinical trials of the COVID-19 vaccine reported the safety and efficacy of mRNA vaccines (AstraZeneca) to help control the disease. Few previous reports have shown various side effects associated with COVID-19 vaccines that vary in severity. The possibility of pericarditis and myocarditis has been observed in people who have received an mRNA COVID-19 vaccine which we are reporting. Acute inflammatory pericarditis can be a rare presentation after receiving the first dose of this vaccine, and it is enriching to share such rare presentations in the era of COVID-19 for better management and outcomes after vaccination. Case Presentation. This is a case of acute inflammatory pericarditis with a small pericardial effusion after receiving the first dose of AstraZeneca COVID-19 vaccine in a healthy adult patient who had no other symptoms suggestive of other viral illness in addition to the negative COVID-19 PCR. A 48-year-old healthy male presented nine days after receiving the first dose of COVID-19 AstraZeneca vaccine. The symptoms started three days after the vaccine, when he complained of progressive retrosternal chest pain with low-grade fever and generalized fatigue, followed by exertional dyspnea after a few days. The diagnosis of acute inflammatory pericarditis with small pericardial effusion was established, and the patient was accordingly treated. One week later, the patient showed significant clinical improvement with the resolution of his pericardial effusion. After 39 days, there was a significant radiological resolution of signs of acute pericarditis.
Conclusion:
The ongoing COVID-19 outbreak is still under investigation, and guidelines are regularly modified since we are continuously learning about this novel disease, although multiple vaccines have been shown to be effective against COVID-19. However, we report a case of unique clinical manifestation that has not been reported widely in the literature, after receiving the first dose of AstraZeneca COVID-19 vaccine, and that it may help raise awareness of the possible diagnosis and the possibility of inflammatory pericarditis after COVID-19 vaccination.
Case report: Tackling the complexities of an extremely premature newborn with intrauterine growth restriction and congenital metabolic disorders through a multidisciplinary approach
Authors: Ioana Roșca, Andrei Gheorghe Preda, Andreea Teodora Constantin, Ciprian Coroleucă, Emilia Severin, Raluca Ioana Teleanu, Alina Turenschi
Journal: Front Pediatr (2023)
Keywords: l-carnitine deficiency, vlbw, extreme premature newborn, hypoglycemia, multidisciplinary approach
MeSH terms: Case Reports

Background and objectives:
The premature birth of a newborn can present a complex challenge for healthcare providers, particularly in cases of extreme prematurity combined with intrauterine growth restriction and multiple metabolic deficiencies. In this report, we aim to shed light on the difficulties and considerations involved in the management of such a case. In addition, our study is aimed to raise awareness of the importance of a multidisciplinary team in managing an extreme premature case with multiple comorbidities.
Case presentation and main findings:
We present the case of a 28-week premature female newborn with very low birth weight (660 g, percentile <10%) and intrauterine growth restriction. She was born through emergency cesarean delivery due to maternal Hemolysis, Elevated Liver enzymes, and Low Platelet count (HELLP) syndrome and had a high-risk pregnancy (spontaneous twin pregnancy, with one fetus stopping development at 16 weeks and maternal hypertension). In the first hours of life, she presented with persistent hypoglycemia requiring progressive glucose supplementation up to 16 g/kg/day to maintain normal blood glucose levels. The baby then showed favorable progress. However, from days 24 to 25, hypoglycemia recurred and did not respond to glucose boluses or supplementation in both intravenous and oral feeds, leading to the suspicion of a congenital metabolic disorder. Endocrine and metabolic screenings led to suspicion of primary carnitine deficiency and a deficiency in hepatic form of carnitine-palmitoyltransferase type I (CPT1) on the second screening.
Conclusion and clinical implications:
The study highlights rare metabolic anomalies that can be due to both organ and system immaturity and delayed enteral feeding and excessive use of antibiotics. The clinical implications of this study emphasize the need for careful monitoring and comprehensive care of premature infants to prevent and manage potential metabolic abnormalities by neonatal metabolic screening.
Diagnosis of Mycobacterium tuberculosis Septic Shock in Patients With Anti-synthetase Syndrome Based on Next-Generation Sequencing: A Case Report and Literature Review
Authors: Limin Sun, Ziyue Yang, Fei Yang, Zhenhua Wang, Hongqiang Li, Huifen Wang, Tongwen Sun
Journal: Front Med (Lausanne) (2021)
Keywords: mycobacterium tuberculosis, bloodstream infection, intensive care unit, sepsis, septic shock
MeSH terms: Case Reports

A 51-year-old woman was transferred to the intensive care unit with such symptoms as fever, swollen left knee joint, pain and hypotension. After preliminary evaluation, she was diagnosed as suffering acute suppurative arthritis and septic shock. Then, she was rescued and prescribed to receive treatment with broad-spectrum antibiotics. However, there was no source of infection identified except for the knee joint. The bacterial and fungal cultures of blood samples and articular effusion were shown to be negative, while the results obtained from the next-generation sequencing of blood and articular effusion revealed that Mycobacterium tuberculosis was positive. The patient was then put on five combinations of anti-tuberculosis therapeutic treatment. Nevertheless, despite the active anti-tuberculosis treatment put in place, her general condition still deteriorated progressively. As the level of her bilirubin continued to rise, further treatment was affected, which prompted the change made to the anti-tuberculosis treatment program. Her clinical condition continued to deteriorate, which led to the development of unstable vital signs and the multiple organ dysfunction syndrome. In spite of our best efforts to save her life, the patient still ended up with death.