OpenMed/multicare-articles huggingface dataset:
A Spontaneous Coronary Artery Dissection Case Noticed during a Primary PCI
Authors: Ismail Dogu Kilic, Halil Tanriverdi, Harun Evrengul, Sukru Gur
Journal: Cardiol Res Pract (2010)
MeSH terms: Case Reports

Spontaneous coronary dissections (SCAD) can be asymptomatic or can manifest itself as any of the clinical spectrum of the ischemic heart disease. In this report, we present a 65 year old man presented with myocardial infarction in whom coronary angiography a nonocclusive SCAD was noticed in addition to a very late stent thrombosis and make a brief overview of the treatment for SCAD.
Missed at Birth: A Rare Case of Acute Pancreatitis Secondary to Congenital Diaphragmatic Hernia
Authors: Ahamed A Khalyfa, Navkiran Randhawa, David Gabbert, Ashirf Al-Ghanoudi
Journal: Case Rep Gastrointest Med (2022)
MeSH terms: Case Reports

Acute pancreatitis is a common gastrointestinal cause of hospitalizations across the world. The most common etiologies of acute pancreatitis include gallstones, excessive alcohol use, hypertriglyceridemia, or, rarely, trauma. Traction-induced pancreatitis is an uncommon but previously reported cause of acute pancreatitis. We present a 60-year-old male with a past medical history of cerebral palsy who presented to our facility with acute pancreatitis secondary to a congenital diaphragmatic hernia.
Case Report: A Boy From a Consanguineous Family Diagnosed With Congenital Muscular Dystrophy Caused by Integrin Alpha 7 ( ITGA7) Mutation
Authors: Wenqing Xia, Zhumei Ni, Zheng Zhang, Hongfei Sang, Huifang Liu, Zhenzhen Chen, Lin Jiang, Congguo Yin, Jinyu Huang, Lingfei Li, Xiaoguang Lei
Journal: Front Genet (2021)
Keywords: a consanguineous family, congenital muscular dystrophy, genetic consultation, integrin alpha 7, rare genetic mutation
MeSH terms: Case Reports

Introduction: Congenital muscular dystrophy (CMD) is a group of early-onset disorders with clinical and genetic heterogeneity. Patients always present with muscle weakness typically from birth to early infancy, delay or arrest of gross motor development, and joint and/or spinal rigidity. There are various genes related to the development of CMD. Among them, mutations in integrin alpha 7 (ITGA7) is a rare subtype. The identification of disease-causing genes facilitates the diagnosis and treatment of CMD. Methods: We screened ITGA7 mutations in four people by whole exome sequencing and targeted sequencing from a consanguineous family. We then carried out electromyography and neuroelectrophysiological examinations to clarify a clinical picture of the patient diagnosed with CMD. Results: We report a Chinese boy diagnosed with CMD who carries a homozygous variant (c.1088dupG, p.H364Sfs*15) of the ITGA7 gene. According to the genotype analysis of his family members, this is an autosomal recessive inheritance. Conclusions: Our case further shows that ITGA7 mutation is related to CMD. Genetic counseling and multidisciplinary management of CMD play an important role in helping patients and their family. Further elucidation of the significant clinical and genetic heterogeneity, therapeutic targets, and the clinical care for patients remains our challenge for the future.
Evaluation of Lymphoproliferative Disease and Increased Risk of Lymphoma in Activated Phosphoinositide 3 Kinase Delta Syndrome: A Case Report With Discussion
Authors: Michele N Pham, Charlotte Cunningham-Rundles
Journal: Front Pediatr (2018)
Keywords: activated phosphoinositide 3-kinase δ syndrome, activating mutations, hypogammaglobinemia, immunodeficiency, lymphoproliferative disease, phosphoinositide 3-kinase
MeSH terms: Case Reports

Activated phosphoionositide-3 kinase delta syndrome (APDS) is a rare disorder caused by activating mutations in phosphoionositide 3-kinase delta (PI3Kδ). This syndrome usually presents in childhood with recurrent sinopulmonary infections and immune deficiency as is seen in the case discussed in this report. Patients with APDS also experience other complications including lymphoid hyperplasia, autoimmunity, increased susceptibility to herpes viruses, especially Epstein-Barr virus and cytomegalovirus, and an increased incidence of B-cell lymphoma. The clinical implications for lymphoid hyperplasia and lymphoma are profound and frequently, it is challenging to distinguish between the two. This case report is of a young girl with a mutation in PIK3CD, the gene encoding the catalytic subunit of PI3Kδ, who presents with asymmetrical cervical lymphadenopathy and parotid swelling. After little improvement in lymphadenopathy on antibiotics, an excisional biopsy of a cervical lymph node was obtained which was initially concerning for lymphoma. This case recounts the clinical decisions made to evaluate this lymphadenopathy and concern for malignancy due to the increased incidence of B-cell lymphoma in this population. It was concluded after careful evaluation of her lymph node histology and cytometry, bone marrow biopsy, and CSF studies that her findings were consistent with lymphoid hyperplasia and not lymphoma and she was treated with rituximab. This case highlights the many comorbidities present in patients with this disease and the current treatments for complications in patients with APDS, including new targeted therapies.
Case Report: Neonatal Urinary Ascites Without Hydronephrosis: A Rare Case of Anterior Urethral Valve and Diverticulum in Preterm Newborn
Authors: Yue He, Sam Bill Lin, WenXuan Li, YuBo Sun, LiangFeng Tang, Rong Zhang
Journal: Front Pediatr (2022)
Keywords: anterior urethral diverticulum, anterior urethral valve, case report, neonate, urinary ascites
MeSH terms: Case Reports

The deformation of congenital obstruction of the anterior urethra is rare in male infants. The anterior urethral valve (AUV) and diverticulum are not common causes of distal urethral obstruction, which may be significant but difficult to diagnose in time. We describe a premature infant who was diagnosed with AUV as part of a diverticulum in the anterior urethra and was presented as massive urinary ascites without hydroureters and hydronephrosis. After indwelling abdominal tube and urinary catheterization, the infant's massive ascites were resolved, while urethral obstruction had successful treatment by Holmium laser. We suggest that the presence of urinary ascites in fetuses and neonates should be considered as a warning against urinary malformations.
Case Report: Successful Treatment With Monoclonal Antibodies in One APDS Patient With Prolonged SARS-CoV-2 Infection Not Responsive to Previous Lines of Treatment
Authors: Beatrice Rivalta, Donato Amodio, Carmela Giancotta, Veronica Santilli, Lucia Pacillo, Paola Zangari, Nicola Cotugno, Emma Concetta Manno, Andrea Finocchi, Stefania Bernardi, Luna Colagrossi, Leonarda Gentile, Cristina Russo, Carlo Federico Perno, Paolo Rossi, Caterina Cancrini, Paolo Palma
Journal: Front Immunol (2022)
Keywords: apds, covid19, iei, sars-cov-2, activated pi3k delta syndrome (apds), long-lasting infection, monoclonal antibody, remdesivir
MeSH terms: COVID-19 Drug Treatment, Case Reports, Research Support, Non-U.S. Gov't, Antibodies, Monoclonal / therapeutic use, Antibodies, Viral, Humans, SARS-CoV-2, Virus Shedding, Antibodies, Monoclonal, Antibodies, Viral

We described the case of a patient affected by activated PI3K-kinase delta syndrome (APDS) and a long-lasting and pauci-symptomatic SARS-CoV-2 infection, treated with multiple therapeutic agents including remdesivir and SARS-CoV-2-neutralizing monoclonal antibodies. We detected the clearance of the virus 105 days from the first positive swab and 7 days after monoclonal antibody administration. At genotyping, the SARS-CoV-2 virus resulted as wild type on all samples tested. This case shows the monoclonal antibodies' good tolerability and efficacy in reducing viral shedding in long-lasting infections refractory to other treatments.
Vital Hepatic Lymphoma Residuum or Excessive Immune Response? Challenging Treatment Decisions in a Patient With Systemic Lupus Erythematosus and Liver-Dominant Diffuse Large B-Cell Lymphoma: Case Report
Authors: Lars Kurch, Thomas W Georgi, Astrid Monecke, Daniel Seehofer, Gudrun Borte, Osama Sabri, Regine Kluge, Simone Heyn, Matthias Pierer, Uwe Platzbecker, Sabine Kayser
Journal: Front Oncol (2022)
Keywords: 18f-fdg-pet/ct, dlbcl, immunoresponse, interdisciplinary approach, systemic lupus eryhematosus
MeSH terms: Case Reports

A 28-year-old female patient with active and difficult-to-treat systemic lupus erythematosus (SLE) was diagnosed with liver-dominant diffused large B-cell lymphoma. Repeated response 18F-FDG-PET studies showed persistently high, and, despite intensified immunochemotherapy, further increasing metabolic activity of one of the hepatic lymphoma residuals, whereas all other initial lymphoma manifestations had achieved complete metabolic remission. As biopsy of the 18F-FDG-PET-positive liver residual turned out to be inconclusive, complete resection was performed. Subsequent histopathological examination, however, revealed only necrotic tissue. Thus, no further lymphoma treatment was scheduled. The patient undergoes regular surveillance and is disease-free 13 months after resection. Similarly, treatment of SLE is no longer required due to lack of activity already after the first two cycles of lymphoma treatment. The case shows how closely SLE and diffused large B-cell lymphoma can be connected and stresses the importance of interdisciplinary treatment approaches. In the future, artificial intelligence may help to further classify 18F-FDG-PET-positive lymphoma residuals. This could lead to an increase of the positive predictive value of interim- and end-of-treatment 18F-FDG-PET. The patient's point of view enables another instructive perspective on the course of treatment, which often remains hidden to treating physicians due to lack of time in clinical routine.
Hepatopulmonary Fistula in a Colorectal Cancer Patient
Authors: Maria João Silva, Nuno Almeida Costa, Susana Dias, Maria José Sousa, Maria Fragoso
Journal: Case Reports Hepatol (2019)
MeSH terms: Case Reports

Cancer patients with liver metastasis may be candidates for liver surgery and local interventional techniques as part of their treatment. Although rare in this setting, hepatopulmonary fistula has been described as a possible complication. The clinical picture may be atypical, and, without specific treatment, it usually has a dismal prognosis. As locoregional treatments (whether interventional or surgical techniques) in liver neoplasms are being more frequently used we need to include this entity as a possible differential diagnosis of local liver treatment complications.
Tamoxifen exposure in pregnancy after synchronous breast and thyroid cancer
Authors: Abeid M Athman Omar, Amany Abdel-Bary, Rasha O Elsaka
Journal: Ecancermedicalscience (2020)
Keywords: breast cancer, pregnancy, tamoxifen, thyroid cancer
MeSH terms: Case Reports

Thyroid and breast cancer are the most common cancers among young women, which are either synchronous or metachronous, but the association is yet to be elucidated. With the improvement of diagnosis and treatment, there is an increase in breast and thyroid cancer survivors. Hence, attention is shifting towards survivorship. Here, we report the case of a young lady diagnosed with synchronous thyroid and breast cancer who unexpectedly became pregnant during tamoxifen treatment. After a multidisciplinary discussion, endocrine therapy was interrupted and she delivered a healthy baby at term. In conclusion, oncologists should be aware of breast and thyroid cancer co-occurrence and examinations should be conducted together in diagnosis and follow-up. Also, pregnancy is feasible and can be considered after synchronous breast and thyroid cancer diagnosis. Physicians need to emphasise the use of barrier contraceptives to patients undergoing endocrine therapy. However, the optimum timing for pregnancy after breast cancer and the safety of endocrine therapy interruption in hormonal-positive patients should be discussed and managed by a multidisciplinary team.
Ureterocolic Fistula Secondary to Diverticulitis of the Sigmoid Colon after Laparoscopic Salpingo-Oophorectomy: A Case Report and Literature Review
Authors: Hirohumi Yamanaka, Satoko Takeuchi, Nao Kirigaya, Akihito Kato, Satoshi Kaseki, Chika Sugita, Shigeko Saito, Tomomitsu Okamoto
Journal: Case Rep Obstet Gynecol (2019)
MeSH terms: Case Reports

Ureterocolic fistula is a rare phenomenon and cases secondary to diverticulitis are even rarer. We present a case of ureterocolic fistula secondary to diverticulitis of the sigmoid colon following laparoscopic salpingo-oophorectomy due to endometriomas. To our knowledge, this is the first case that occurred in a patient with gynecologic surgery.
Telemonitoring system for patients with chronic kidney disease undergoing peritoneal dialysis: Usability assessment based on a case study
Authors: Marcos Antonio Martínez García, Martha Socorrro Fernández Rosales, Eduardo López Domínguez, Yesenia Hernández Velázquez, Saúl Domínguez Isidro
Journal: PLoS One (2018)
MeSH terms: Monitoring, Physiologic, Peritoneal Dialysis, Renal Insufficiency, Chronic / therapy, Telemedicine, Observational Study, Research Support, Non-U.S. Gov't, Adult, Aged, Attitude of Health Personnel, Female, Humans, Longitudinal Studies, Male, Middle Aged, Patient Acceptance of Health Care, Prospective Studies, Renal Insufficiency, Chronic / psychology, Young Adult

There are two million people with chronic kidney disease (CKD) worldwide. In Mexico, it is estimated that by 2025, there will be 212 thousand CKD cases. Among the renal replacement treatments, peritoneal dialysis (PD) exists either in the continuous ambulatory (CAPD) or automated (APD) mode, which requires continuous monitoring and strict control. Thus, several software systems have been proposed to perform reliable remote monitoring of patients using PD but also to achieve the goal with effectiveness, efficiency and satisfaction; i.e., in software engineering, this is called usability. However, few studies have addressed usability issues using case studies with patients and medical staff in real domains. In this paper, we present a usability assessment of a telemonitoring system for patients with CKD on peritoneal dialysis treatment through a case study with patients and medical staff of the Mexican Institute of Social Security (IMSS). The usability evaluation was carried out through the application of two satisfaction instruments. These instruments evaluated multiple usability criteria, such as navigability, interactivity, motivation, satisfaction, and applicability. The results obtained from the usability evaluation show that, on average, the services offered by the system have 91.3% acceptance by users (patient-doctors), with the APD and CAPD exchange data registration services having the highest acceptance for patients, with a positive perception of 94.5% and 92.3%, respectively. Meanwhile, for the doctors and nurses, the alarm reception for patients in a risk situation was highest with 95% acceptance. Based on the obtained results, the evaluated telemonitoring system holds wide acceptance, satisfaction, and applicability from patients' and doctors' perspectives. It is also noted that the evaluated system considers and satisfies the requirements and suitable parameters that should be monitored in PD treatment according to studies presented in the literature.
Motor Skill Improvement Using Compressive Garments in a Child with Multidimensional Impairments and Ehlers-Danlos Syndrome
Authors: Jean Xavier, Soizic Gauthier, Ingrid Zammouri, Salvatore Maria Anzalone, David Cohen
Journal: Case Rep Psychiatry (2022)
MeSH terms: Case Reports

We report the case of an 8-year-old child with a complex neurodevelopmental disorder, including severe developmental coordination disorder with dysgraphia, anxiety and depression, mild social functioning impairments, headache and chronic musculoskeletal pain, secondary to Ehlers-Danlos syndrome (EDS) hypermobility type. We explored whether wearing whole-body compressive garments (CGs) could improve his motor skills assessed through standardized and experimental procedures. In addition to the effectiveness of CGs on pain, we found partial improvements in his motor skills, specifically postural control, hand movements, and body schema representation, after wearing CGs for 15 days. During an experimental motor imitation task with a virtual tightrope walker, we found improvements in interpersonal synchronization with performances closer to those of typical developing (TD) controls. We conclude that CGs appear to be an innovative and interesting adjuvant treatment for motor skill impairments in children with multidimensional impairments involving EDS. These promising results require confirmation by further evidence-based research.
Surgical Treatment of an Immature Short-Rooted Traumatized Incisor with an Extensive Apical Lesion Using CEM Cement
Authors: Saeed Asgary, Mahta Fazlyab
Journal: Iran Endod J (2015)
Keywords: biomaterials, cem cement, calcium-enriched mixture, endodontic, periapical cyst, periradicular lesion, root-end surgery
MeSH terms: Case Reports

Severe traumatic injuries to immature teeth often cause damage to periodontal ligament as well as dental pulp; pulp necrosis, root resorption and subsequent apical lesion are common consequences. This article reports the surgical management of an infected immature maxillary central incisor associated with a gigantic periradicular lesion and severe root resorption. The tooth had a history of trauma and the patient suffered from purulent sinus tract and tooth mobility. After unsuccessful multi-session disinfection with calcium hydroxide, root end surgery was planned. During flap surgery and lesion enucleation, the root end was cleaned and filled with calcium-enriched mixture (CEM) cement. After one year, the radiographic examination revealed that the lesion was almost completely replaced with newly formed bone. In addition, clinical examination showed favorable outcomes; the tooth was symptom-free and in function. Due to chemical, physical and biological properties of CEM cement, this biomaterial might be considered as the root-end filling material of choice.
Case Report: Generalised Panniculitis as a Post-COVID-19 Presentation in Aicardi-Goutières Syndrome Treated With Ruxolitinib
Authors: Abirami Pararajasingam, Rachel E Bradley, Jennifer Evans, Ashima Lowe, Richard Goodwin, Stephen Jolles
Journal: Front Pediatr (2022)
Keywords: aicardi-goutières syndrome, covid-19, samhd1 mutation, panniculitis, ruxolitinib
MeSH terms: Case Reports

Aicardi-Goutières syndrome (AGS) is a rare hereditary early-onset encephalopathy. The syndrome was first described in 1984, and is characterised by upregulation of the type I interferon (IFN) pathway, which is involved in the host immune response against viral infections, including SARS-CoV-2. Whilst defects in type I IFN pathways have been described in association with severe coronavirus disease 2019 (COVID-19), less is known about the outcomes of upregulation. We describe an unusual case of generalised panniculitis as a post-COVID-19 phenomenon in a child with AGS. Our patient was initially managed with systemic steroid therapy, but due to relapse of symptoms on weaning, an alternative therapy was sought. In this case, a novel use of ruxolitinib, a JAK inhibitor, has resulted in lasting remission without complications. We discuss the probable protective role of IFN upregulation following COVID-19 infection in AGS and possible immunological mechanisms driving the panniculitis and therapeutic response in our case.
Staphylococcus lugdunensis Endocarditis in a 35-Year-Old Woman in Her 24th Week of Pregnancy
Authors: Mounir Khafaga, Karl-Patrik Kresoja, Berndt Urlesberger, Igor Knez, Philipp Klaritsch, David Benjamin Lumenta, Robert Krause, Dirk von Lewinski
Journal: Case Rep Obstet Gynecol (2016)

Background. Infective endocarditis is associated with considerable morbidity and mortality. Guidelines addressing prophylaxis and management of infective endocarditis do not extensively deal with concomitant pregnancy, and case reports on infective endocarditis are scarce. This is the first published report of infective endocarditis by Staphylococcus lugdunensis in a pregnant woman. Case Presentation. We report a single case of a 35-year-old woman in her 24th week of pregnancy who was admitted to our intensive care unit with fever and suspected infectious endocarditis. Blood culture detected Staphylococcus lugdunensis. A vegetation and severe mitral regurgitation due to complete destruction of the valve confirmed the diagnosis. An interdisciplinary panel of cardiologists, maternal-fetal medicine specialists, cardiac and plastic surgeons, infectiologists, anesthesiologists, and neonatologists was formed to determine the best therapeutic strategy. Conclusions. Timing and indications for surgical intervention to prevent embolic complications in infective endocarditis remain controversial. This original case report illustrates how managing infective endocarditis by Staphylococcus lugdunensis particularly in the 24th week of pregnancy can represent a therapeutic challenge to a broad section of specialties across medicine. Critical cases like this require a thorough weighing of risks and benefits followed by swift action to protect the mother and her unborn child.
Acute acalculous cholecystitis following COVID-19 vaccination: a case report
Authors: Fabien Mukonki Kyungu, Aude Mukonki Katumba, Hermann Luhavo Kamwira, Aime Vonda Mayikuli, Adou Mala, Manix Ilunga Banza, Haladou Mahaman Manirou, Fiston Bolanda Tosali, Philippe Cilundika Mulenga
Journal: Pan Afr Med J (2022)
Keywords: acute acalculous cholecystitis, covid-19 vaccination, case report, liver dysfunction
MeSH terms: Acalculous Cholecystitis / diagnosis, Acalculous Cholecystitis / etiology, COVID-19 Vaccines / adverse effects, COVID-19 / prevention & control, Cholecystitis, Acute / diagnosis, Cholecystitis, Acute / etiology, Case Reports, Adult, Aged, Humans, Male, Vaccination, COVID-19 Vaccines

Acute acalculous cholecystitis is an acute inflammation of the gallbladder in the absence of stones, usually occurring in elderly and critically ill patients with underlying conditions. A 29-year-old man presented to the hospital complaining of abdominal pain in the right hypochondrium with permanent fever three days after Janssen COVID-19 vaccine inoculation. Abdominal ultrasound revealed a thickened gallbladder wall without evidence of gallstone consistent of an acute acalculous cholecystitis. Blood analyses revealed thrombocytopenia, eosinophilia and liver dysfunction. The Polymerase Chain Reaction (PCR) COVID-19 test was negative. As treatment, the patient benefited of pain management, antibiotic and fluid. In the evolution, there was a regression of clinical signs with persistence of liver dysfunction. The patient was discharged ten days after hospitalization. The Janssen COVID-19 vaccine is likely to induce acute acalculous cholecystitis as adverse event following vaccination.