OpenMed/multicare-articles huggingface dataset:
A reclusive foreign body in the airway: a case report and a literature review
Authors: Ajay Philip, V Rajan Sundaresan, Philip George, Satyabrata Dash, Regi Thomas, Anand Job, V K Anand
Journal: Case Rep Otolaryngol (2013)

A foreign body in the larynx is an airway emergency that requires urgent evaluation and treatment. Irregular foreign bodies tend to orient in a sagittal plane and may produce only partial obstruction, allowing adequate air movement, hence making them undetectable for a long period of time. We report a case of a laryngotracheal foreign body that remained reclusive for 9 years.
Yersinia enterocolitica in Italy: A Case of Septicemia and Abdominal Aortic Aneurysm Infection
Authors: Donatella M Rodio, Alessia Bressan, Cecilia Ambrosi, Daniela Scribano, Rita Tolli, Wassim Mansour, Francesco Speziale, Guido Antonelli, Maria Trancassini, Valeria Pietropaolo
Journal: Front Med (Lausanne) (2018)
Keywords: yersinia enterocolitica, aortic aneurysm, septicemia, serogroup o
MeSH terms: Case Reports

We report a case of Yersinia enterocolitica septicemia in a 63-year-old patient admitted to the Vascular Surgery Department of Umberto I Hospital (Rome, Italy) for an abdominal aortic aneurysm. The microorganism, recovered from both peripheral blood cultures and aneurysmatic aortic wall specimens, was identified as Y. enterocolitica using matrix-assisted laser desorption ionization-time of flight analysis (MALDI-TOF MS) and 16S rDNA gene sequencing. The isolate responsible for septicemia belonged to the O:9 serotype (biogroup 2). A genetic screening of the isolate made it possible to detect the presence of both the yst and ail genes, encoding a heat-stable enterotoxin and a protein involved in invasion/adherence and serum resistance, respectively. Our case contributes in enriching epidemiological data concerning Y. enterocolitica infections, which might represent severe complications in patients suffering from cardiovascular diseases. Moreover, this study, together with the others, should be regarded as valuable and useful tools for monitoring the rate of infections worldwide.
Characteristic waffle-like appearance of gastric linitis plastica: A case report
Authors: Emiko Maeda, Makoto Oryu, Joji Tani, Hisaaki Miyoshi, Asahiro Morishita, Hirohito Yoneyama, Hideki Kobara, Hirohito Mori, Tsutomu Masaki
Journal: Oncol Lett (2015)
Keywords: diffuse type cancers, linitis plastica, scirrhous gastric cancer, signet ring cell adenocarcinoma, waffle-like appearance

Linitis plastica is a gastric cancer of diffuse histotype that presents in the fundic gland area, and is characterized by thickening of the stomach wall and deformation of the stomach, resulting in a leather bottle-like appearance. A 66-year-old female was admitted to Kagawa University Hospital (Kagawa, Japan) with epigastric pain. X-ray examination revealed reduced gastric distension and deformation of the stomach, which exhibited a leather bottle-like appearance. Endoscopy indicated a depressed lesion in the gastric antrum, and abnormal folds, which crossed to form a waffle-like appearance in the upper gastric body. Analysis of biopsy specimens from the depressed lesion revealed a poorly differentiated adenocarcinoma. Morphological changes in the gastric folds indicated that the tumor had invaded the upper gastric body, therefore, a total gastrectomy was performed. Subsequent pathological findings demonstrated that the tumor had spread from the primary lesion to the upper gastric body. Therefore, the present report recommends that the diagnosis of the spread of linitis plastica-type gastric cancer should include assessments of the primary lesion, as well as evaluation of morphological changes in the gastric folds.
Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) with preserved refractory period: report of three cases
Authors: Vimal Kumar Paliwal, Prabhat Singh, Achal Kumar, Sushil Kumar Rahi, Rakesh Kumar Gupta
Journal: J Headache Pain (2012)
MeSH terms: Refractory Period, Electrophysiological / physiology, SUNCT Syndrome / diagnosis, SUNCT Syndrome / physiopathology, Case Reports, Humans, Male, Middle Aged

Background:
Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) and short-lasting unilateral neuralgiform attacks with cranial autonomic features (SUNA) are rare primary headache syndromes characterized by spontaneous or triggered attacks of unilateral, brief, multiple, orbitofrontal pain associated with ipsilateral autonomic features. SUNCT is considered as a subset of SUNA. In SUNA, there may be cranial autonomic symptoms other than conjunctival injection and lacrimation, or either of two is present. SUNCT/SUNA can be triggered immediately after or at the decrescendo phase of the ongoing attack without any intervening refractory period. Refractory period is usually present in trigeminal neuralgia. Absent refractory period is thought to reliably differentiate SUNCT/SUNA from trigeminal neuralgia and has been proposed for inclusion into the International Classification of Headache Disorders (ICHD) diagnostic criteria for SUNCT.
Case reports:
We report three patients of SUNCT syndrome with preserved intervening refractory period of variable duration observed at different times.
Discussion:
Trigeminal neuralgias with autonomic features, SUNA and SUNCT share a common pathophysiological mechanism and actually represent a continuum. It is well known that patient with trigeminal neuralgia may transform into SUNCT/SUNA. Similarly, being a continuum, the presence or the absence of refractory period and its duration may change in a patient with SUNCT/SUNA at different time points.
Conclusion:
The presence of refractory period should not exclude the diagnosis of SUNCT in a patient with other clinical features suggestive of SUNCT.
Malignant progression in two children with multiple osteochondromas
Authors: Gregory A Schmale, Douglas S Hawkins, Joe Rutledge, Ernest U Conrad
Journal: Sarcoma (2010)
MeSH terms: Case Reports

Multiple Osteochondromas (MO) is a disease of benign bony growths with a low incidence of malignant transformation. Secondary chondrosarcoma in children is rare even in children with MO. Making a diagnosis of malignancy in low-grade cartilage tumors is challenging and requires consideration of clinical, radiographic, and histopathological factors. We report two cases of skeletally immature patients with MO who presented with rapidly enlarging and radiographically aggressive lesions consistent with malignant transformation. Both underwent allograft reconstruction of the involved site with no signs of recurrence or metastatic disease at a minimum of four-year follow-up.
Decision Support for Mitigation of Livestock Disease: Rinderpest as a Case Study
Authors: Judith R Mourant, Paul W Fenimore, Carrie A Manore, Benjamin H McMahon
Journal: Front Vet Sci (2018)
Keywords: culling, epidemic, mechanistic model, mitigation, rinderpest, spatial model, vaccination

A versatile, interactive model to predict geographically resolved epidemic progression after pathogen introduction into a population is presented. Deterministic simulations incorporating a compartmental disease model run rapidly, facilitating the analysis of mitigations such as vaccination and transmission reduction on epidemic spread and progression. We demonstrate the simulation model using rinderpest infection of cattle, a devastating livestock disease. Rinderpest has been extinguished in the wild, but it is still a threat due to stored virus in some laboratories. Comparison of simulations to historical outbreaks provides some validation of the model. Simulations of potential outbreaks demonstrate potential consequences of rinderpest virus release for a variety of possible disease parameters and mitigations. Our results indicate that a rinderpest outbreak could result in severe social and economic consequences.
Submassive Pulmonary Thromboembolism in a Patient with Thrombocytopenia: Therapeutic Challenge
Authors: Ronni Andrea Muñoz Tovar, Luis Carlos Alvarez Perdomo, Sandra Milena Rojas Molina, Silvana Jimenez Salazar
Journal: Case Rep Crit Care (2019)
MeSH terms: Case Reports

Venous thromboembolic disease is an important cause of mortality worldwide. A widely recognized risk factor is active neoplasia, mainly hematological tumors, in which associated thrombocytopenia can be a frequent complication. We present the case of a patient with submassive pulmonary thromboembolism associated with severe thrombocytopenia with signs of right heart failure and a requirement for systemic thrombolysis and anticoagulation, however with absolute contraindication for them. The case establishes a therapeutic challenge for the treating group, leading us to carry out an extensive search of the literature and propose a management algorithm in this complex situation.
Disseminated Blastomycosis Presenting as Oligoarthritis, Pneumonia, and Skin Disease in an Immunocompetent Child
Authors: Emily Schildt, Robyn Bockrath
Journal: Case Rep Pediatr (2021)
MeSH terms: Case Reports

Blastomyces species (spp) can cause clinical disease affecting nearly every organ system, including the skeletal system. However, isolated joint involvement without concurrent osteomyelitis is rare, especially in children. We present a pediatric case from a tertiary care center in urban Chicago of disseminated blastomycosis caused by Blastomyces dermatitidis presenting as oligoarthritis (in the absence of osteomyelitis), pneumonia, and skin involvement, with clinical improvement on IV amphotericin and oral azole treatment.
Opinions of Teachers on Distance Education Applications in English Language Teaching Policies in Northern Cyprus During the COVID-19 Pandemic
Authors: Merve Uysal, Çağda Kıvanç Çağanağa
Journal: Front Psychol (2022)
Keywords: covid-19, northern cyprus, distance education, foreign language education policy, foreign language teaching

The COVID-19 pandemic affected education institutions just like several other sectors. These institutions, which are among the places where people are found collectively, were the first places that were closed for precaution. Some problems of distance education conducted in online platforms which were assumed upon the termination of face-to-face education emerged in time. Especially in this urgent solution, where the workload of teachers has increased, some application difficulties have been identified in foreign language teaching. From this point of view, considering the foreign language education policy and planning, this study deals with the distance education practices of English teachers, the difficulties they encounter in the process, and their solution proposals. The research, which was designed as a qualitative study, was conducted with a case study design. The participants of the research are 13 English teachers working at the secondary school level in different districts of Northern Cyprus determined by the homogeneous sampling method. The data were collected through semi-structured interviews developed by the researchers. The qualitative data were analyzed with descriptive analysis. As a result of the interviews with the teachers, it has been determined that there are problems related to technology, students, online classes, and planning in English teaching carried out with distance education applications. Accordingly, the teachers offered their recommendations that could be a solution to the existing problems.
Cardiac Involvement by HIV-Associated DLBCL
Authors: Charles T Mupamombe, Jude Noel, Derek B Laskar, Liza Valdivia
Journal: Case Rep Med (2018)
MeSH terms: Case Reports

Non-Hodgkin's lymphoma (NHL) is a common AIDS-defining malignancy among people living with HIV. Of the different types of NHLs, diffuse large B-cell lymphoma (DLBCL) is the most common. Prognosis of DLBCL has improved over the years in the general population but remains relatively poor in HIV-positive individuals. Almost any organ system can be affected by DLBCL; however, cardiac involvement remains rare and suggests aggressive disease. We present a case of DLBCL in an HIV-positive patient, who had cardiac involvement, with the only clue to cardiac involvement being symptom being tachycardia and dysphagia.
NSCLC patients with rare EGFR Ex19del/G724S mutation showed good response to afatinib combined with chemotherapy treatment: A two-case report
Authors: Huilin Wang, Qitao Yu, Lina Shi, Qinhan Hou, Liang Dan, Chuqiao Liang, Xiaoyu Hong, Yun Zhao, Ruiling Ning
Journal: Front Oncol (2022)
Keywords: egfr ex19del, egfr g724s, afatinib, chemotherapy, non-small cell lung cancer
MeSH terms: Case Reports

EGFR G724S mutation in exon 18 has been shown to be resistant to both first- and third-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs). However, we found a rare mutation of EGFR Ex19del/G724S in two patients with lung cancer who demonstrated a favorable response to the combination of afatinib and chemotherapy. Identified by next-generation sequencing (NGS), EGFR G724S was found from a primary and a secondary tumor biopsy, respectively. Treated with afatinib combined with chemotherapy, both patients responded well and achieved progression-free survival. Analysis of acquired mutations developed during treatment using afatinib revealed that the emergence of EGFR T790M or ALK fusion was the potential mechanism of afatinib resistance. Our study lends credence to treatment using afatinib combined with chemotherapy as a viable option for patients with Ex19del/G724S.
Successful treatment of a patient with renal failure, treated with haemodialysis, and advanced ovarian germ cell tumour using modified cisplatin-based chemotherapy duplet
Authors: Viridiana Méndez-Calderillo, Gerardo Nuñez-Saldaña
Journal: Ecancermedicalscience (2022)
Keywords: chemotherapy, cisplatin, haemodialysis, kidney failure, ovarian germ cell cancer
MeSH terms: Case Reports

There are no reports on chemotherapy treatment in patients with ovarian germ cell tumours and kidney failure. We report the case of a 29-year-old female diagnosed with an advanced right ovarian germ cell tumour and severe kidney damage treated with haemodialysis. The first cycle of chemotherapy was administered with 10 mg/m2 of cisplatin on days 1, 3, and 5, and 35 mg/m2 of etoposide from day 1 through 5, followed by haemodialysis 1 hour after the end of cisplatin infusion on days 1, 3, and 5, with grade 3 haematologic toxicity. After the first cycle, kidney function improved and haemodialysis was suspended. From the second cycle onwards, the dose was increased to 80% cisplatin and 100% etoposide with grade 3 haematologic toxicity; following that, the dose of etoposide was decreased to 80% in cycle 3. In the face of tumour progression, the regimen was changed to a standard dose of ifosfamide on days 1 through 5, and carboplatin on day 1 calculated at the area under the plasma concentration curve of free carboplatin versus time of 5 mg/ml/minute. An 80% dosage of ifosfamide and cisplatin was used from the second to fourth cycle, achieving partial response by imaging. The patient was taken to surgery and there was no histopathological evidence of viable cancer cells. In conclusion, cisplatin-based chemotherapy can be administered to a patient with advanced ovarian germ cell tumour and renal insufficiency at lower doses to prevent side effects while retaining efficacy in a multidisciplinary treatment setting.
Inflammatory myofibroblastic tumour of the gallbladder
Authors: Kasim A Behranwala, Peter Straker, Andrew Wan, Cyril Fisher, Jeremy N Thompson
Journal: World J Surg Oncol (2005)

BACKGROUND: Inflammatory myofibroblastic tumour (IMT) is a benign, nonmetastasizing proliferation of myofibroblasts with a potential for local infiltration, recurrence and persistent local growth. CASE REPORT: We report a case of a 51 year-old female, who had excision of a gallbladder tumour. Histopathology showed it to be IMT of the gallbladder. CONCLUSION: The approach to these tumours should be primarily surgical resection to obtain a definitive diagnosis and relieve symptoms. IMT has a potential for local infiltration, recurrence and persistent local growth.
Contralateral Posterior Chamber Phakic Intraocular Lens Implantation as Rehabilitation of Refractive Lens Exchange with a Monofocal Intraocular Lens in a Young, Nonpresbyopic, Bilateral Highly-Myopic Patient
Authors: Kepa Balparda, Claudia Marcela Vanegas-Ramírez, Laura Segura-Muñoz, Manuela Gómez-Londoño
Journal: Case Rep Ophthalmol Med (2019)
MeSH terms: Case Reports

Background:
Refractive errors are widespread in the human population; nowadays, numerous surgical options allow for efficient and safe correction them. One of the main elements to ensure success in this kind of intervention will depend on the careful patient and surgical approach selection. Excimer laser corneal surgery is considered by most for low to moderate ametropias. Another option, which has been suggested may be safer, is to cut a small corneal lenticule with femtosecond laser, and then extracting it through a small incision. Nevertheless, in some specific cases, such as patients with high refractive error or those with some corneal abnormality, laser corneal ablations are considered unsafe from either a biomechanical or refractive standpoint. In this kind of particular cases, Phakic Intraocular Lens (P-IOL) implantation constitutes attractive, highly predictable and safe option.
Objective:
The authors want to show the case of a young high-myopic woman, already pseudophakic in one eye, where the P-IOL implantation in the fellow eye yielded excellent short-term visual results, and high patient's satisfaction, is presented.
Materials:
The authors present the case of a 32-years-old, highly myopic female patient underwent a Refractive Lens Exchange (RLE) with a monofocal Intraocular Lens (IOL) implantation in her left eye elsewhere, and developed severe visual issues, especially regarding near-work. Symptoms resolved through the implantation of a posterior chamber P-IOL in the contralateral eye.
Results:
The postoperative course was unremarkable, inflammation was mild, and visual recovery was quick. There was no need to perform any procedure on her left eye or to use any reading glasses, as unilateral effective near vision through her right eye was enough for all her daily tasks.
Conclusions:
RLE in young pre-presbyopic highly myopic patients may not be an advisable alternative in most cases, because of the high risks of retinal complications observed. In addition, eliminating accommodation will cause significant limitations, and multifocal IOLs currently available are far from the quality of vision that a young human crystalline lens yields. On the other hand, implantation of a P-IOL is a good option if eye conditions are optimal, as it preserves natural accommodation. In this case an EyeCryl Phakic Toric® IOL showed excellent short-term refractive predictability and safety.
Cerebrovascular Accident due to Thyroid Storm: Should We Anticoagulate?
Authors: Alex Gonzalez-Bossolo, Alexis Gonzalez-Rivera, Santiago Coste-Sibilia
Journal: Case Rep Endocrinol (2016)

Thyroid storm is a life-threatening condition that occurs secondary to an uncontrolled hyperthyroid state. Atrial fibrillation is a cardiovascular complication occurring in up to 15% of patients experiencing thyroid storm, and if left untreated this condition could have up to a 25% mortality rate. Thyroid storm with stroke is a rare presentation. This case report details a left middle cerebral artery (MCA) stroke with global aphasia and thyroid storm in a 53-year-old Hispanic male patient. Although uncommon, this combination has been reported in multiple case series. Although it is well documented that dysfunctional thyroid levels promote a hypercoagulable state, available guidelines from multiple entities are unclear on whether anticoagulation therapy is appropriate in this situation.
Case Report: The first probable Hong Kong Chinese case of LPIN1-related acute recurrent rhabdomyolysis in a boy with two novel variants
Authors: Sau Wing Yim, Tina Yee Ching Chan, Kiran M Belaramani, Sze Shun Man, Felix Chi Kin Wong, Sammy Pak Lam Chen, Hencher Han Chih Lee, Chloe Miu Mak, Chor Kwan Ching
Journal: F1000Res (2019)
Keywords: hong kong chinese, lpin1, novel variants, rhabdomyolysis
MeSH terms: Myoglobinuria, Phosphatidate Phosphatase / genetics, Rhabdomyolysis / diagnosis, Rhabdomyolysis / genetics, Case Reports, Female, Hong Kong, Humans, Infant, Language, Male, LPIN1 protein, human, Phosphatidate Phosphatase

Recurrent rhabdomyolysis is frequently ascribed to fatty acid ß-oxidation defects, mitochondrial respiratory chain disorders and glycogen storage-related diseases. In recent years, autosomal recessive LPIN1 mutations have been identified as a prevailing cause of severe rhabdomyolysis in children in Western countries. We report the first probable Hong Kong Chinese case of recurrent severe rhabdomyolysis in early childhood caused by LPIN1 variants. Compound heterozygous novel variants NM_145693.2(LPIN1):c.[1949_1967dupGTGTCACCACGCAGTACCA]; [2410G>C] (p.[Gly657Cysfs*12];[Asp804His]) were detected. The former variant was classified as likely pathogenic while the latter variant was classified as a variant of uncertain significance (VUS) based on the guideline published by the American College of Medical Genetics and Genomics (ACMG) in 2015. Although the genetic findings were inconclusive, the patient's presentation was compatible with LPIN1-related acute recurrent rhabdomyolysis, and the patient was treated as such. The early recognition, timely diagnosis and management of this condition are important to avoid fatal consequences. To our knowledge, there has been no previous report in the English-language literature of a child with Chinese ethnicity and LPIN1-related acute recurrent rhabdomyolysis (MIM #268200). Functional characterization of the novel variants detected in this study are warranted in future studies.