OpenMed/multicare-articles huggingface dataset:
Case report: Treating a co-existence of hidradenitis suppurativa and psoriasis with different therapeutic approaches
Authors: Eleftheria Tampouratzi, Theodora Kanni, John Katsantonis, Theodora Douvali
Journal: F1000Res (2019)
Keywords: brodalumab, certolizumab, hidradenitis suppurativa, psoriasis
MeSH terms: Hidradenitis Suppurativa / complications, Hidradenitis Suppurativa / drug therapy, Psoriasis / complications, Psoriasis / drug therapy, Case Reports, Adult, Antibodies, Monoclonal, Humanized / therapeutic use, Certolizumab Pegol / therapeutic use, Female, Humans, Male, Quality of Life, Skin, Antibodies, Monoclonal, Humanized, brodalumab, Certolizumab Pegol

Hidradenitis suppurativa and psoriasis are considered chronic inflammatory diseases suggesting the existence of common pathogenetic pathways. We present two cases of comorbid psoriasis and hidradenitis suppurativa, treated with certolizumab pegol and brodalumab due to failure of response to other conventional therapies. Monoclonal antibody therapies have revolutionized the treatment of chronic inflammatory disorders such as psoriasis and hidradenitis suppurativa. Given the good clinical response to anti-IL-17 and anti-tumor necrosis factor agents in patients undergoing psoriasis and hidradenitis treatment, investigations on this direction could represent the starting point in new therapeutic approach for revolutionary treatment in these difficult-to-treat diseases.
A rare case of Candida parapsilosis osteomyelitis: a literature review and proposed treatment algorithm
Authors: John Michael Yingling, Li Sun, Richard Yoon, Frank Liporace
Journal: Patient Saf Surg (2017)
Keywords: acute and chronic deep fungal infection management, ankle fracture, exposed hardware, fungus, irrigation and debridement, negative pressure wound therapy, removal of hardware, saucerization
MeSH terms: Case Reports

Background:

Candida parapsilosis is a rare opportunistic pathogen that can be found in immunosuppressed patients. There are seldom-reported cases of fungal osteomyelitis surrounding orthopedic implants.
Case presentation:
This is a case of chronic Candida parapsilosis osteomyelitis in an immunocompromised patient with a prior open reduction and internal fixation for a closed bimalleolar ankle fracture that went on to neglected wound complications. The patient underwent series of treatments including removal of hardware, serial irrigation and debridements, negative pressure wound therapy, and intravenous antifungal therapy. Our case illustrates the possibility of this rare pathogen involved in orthopedic surgery particularly in immunocompromised hosts.
Conclusion:
Fungal and atypical pathogens should always be considered in such patients or if another diagnosis is not clear. Protracted time to culture specimens should be considered for at least four weeks in such situations. This article outlines a review of the literature and treatment algorithm to guide physicians when managing patients with this rare infection.
Persistent Tn polyagglutination syndrome during febrile neutropenia: a case report and review of the literature
Authors: Arturo Loaiza-Bonilla, Daniel Horowitz, Sheenu Sheela, Anupa Baral, Gabriel Tinoco, Christos Kyriakopoulos
Journal: J Med Case Rep (2011)

Introduction:
Tn polyagglutination syndrome is a rare disorder that has been reported on only a few occasions in the literature, and, to the best of our knowledge, never before in the context of febrile neutropenia.
Case presentation:
We report the case of a 26-year-old Caucasian woman who presented to our emergency department complaining of a persistent fever over the previous three days. She had a history of long-standing refractory pancytopenia with multi-lineage dysplasia and severe neutropenia, but she had rarely experienced infection. The results of a physical examination and multiple laboratory tests were unremarkable. While investigating the possible causes of the refractory, long-standing pancytopenia, the possibility of a polyagglutinable state was suggested. Blood samples were sent to the laboratory for an analysis of mixed-field seed lectin agglutination assay. A serum lectin panel confirmed the final diagnosis of Tn-activation.
Conclusions:
We should include Tn-activation in our differential whenever we encounter cases of refractory long-standing idiopathic cytopenias and inconclusive bone marrow results displaying multi-lineage dysplasia. Novel genetic techniques have recently revealed the interesting pathophysiology of this phenomenon. The recognition and inclusion of Tn polyagglutination syndrome in our differential diagnoses has important clinical implications, given its main associated features, such as severe thrombocytopenia and neutropenia, which are usually linked to a benign clinical course and prognosis. Increased awareness of the polyagglutinable disorders will potentially decrease the need for invasive and costly medical interventions and also raises the need for monitoring of this specific sub-set of patients. In addition, the study of the expression and implications of Tn, and other similar antigens, offers a fascinating perspective for the study of its role in the diagnosis, prognosis and immunotherapy of solid tumors and hematological malignancies. The infrequency with which Tn polyagglutination syndrome is encountered, its clinical features and its pathophysiology make it a formidable diagnostic challenge.
Laparoscopic resection of a leiomyoma of the seminal vesicle
Authors: Bernard Lallemand, Philippe Busard, Frederic Leduc, Roland Vaesen
Journal: Indian J Urol (2007)
Keywords: laparoscopic, leiomyoma, seminal vesicle
MeSH terms: Case Reports

We present a case of a leiomyoma of the seminal vesicle that occurred in a 52-year-old man who presented with symptoms of bladder outlet obstruction. Prostate-specific antigen was within normal limit. Computed tomography scan and magnetic resonance imaging revealed a mass in the patient's right seminal vesicle. Laparoscopic excision of the seminal vesicle tumor was performed successfully. The patient was discharged from the hospital on the fourth postoperative day.
Bilateral Terrien's Marginal Degeneration and Posterior Polymorphous Dystrophy in a Patient with Rheumatoid Arthritis
Authors: Siamak Zarei-Ghanavati, Mohammad-Ali Javadi, Shahin Yazdani
Journal: J Ophthalmic Vis Res (2012)
Keywords: corneal ectasia, posterior polymorphous dystrophy, rheumatoid arthritis, terrien’s marginal degeneration
MeSH terms: Case Reports

Purpose:
To report an interesting case of concomitant bilateral Terrien's marginal degeneration-like corneal ectasia and posterior polymorphous corneal dystrophy in a young man with quiescent rheumatoid arthritis.
Case report:
A 24-year-old man with history of rheumatoid arthritis presented with bilateral decreased vision since four years ago. Slit lamp examination revealed bilateral circumferential peripheral corneal thinning and bulging with vascularization and lipid deposition in addition to band-like lesions in descemet's membrane. Previous records revealed no gross corneal abnormalities up to 4 years ago. Corneal lesions were compatible with bilateral circumferential Terrien's marginal degeneration concomitant with posterior polymorphous dystrophy.
Conclusion:
To our knowledge, this is the first report of concomitant bilateral Terrien's marginal degeneration with peripheral corneal ectasia and posterior polymorphous dystrophy in a patient with rheumatoid arthritis. Bilateral circumferential involvement, younger age at presentation and total peripheral corneal ectasia as observed in this case are not typical for classic Terrien's marginal degeneration.
Osteoid osteoma near the intervertebral foramen may induce radiculopathy through tumorous inflammation
Authors: Michihisa Zenmyo, Takuya Yamamoto, Yasuhiro Ishidou, Setsuro Komiya, Kosei Ijiri
Journal: Diagn Pathol (2011)
MeSH terms: Bone Neoplasms / complications, Inflammation / complications, Intervertebral Disc / diagnostic imaging, Intervertebral Disc / pathology, Osteoma, Osteoid / complications, Radiculopathy / etiology, Case Reports, Research Support, Non-U.S. Gov't, Adolescent, Adult, Bone Neoplasms / diagnosis, Bone Neoplasms / surgery, Humans, Inflammation / diagnosis, Lumbar Vertebrae / diagnostic imaging, Lumbar Vertebrae / pathology, Magnetic Resonance Imaging, Male, Osteoma, Osteoid / diagnosis, Osteoma, Osteoid / surgery, Radiculopathy / diagnosis, Thoracic Vertebrae / diagnostic imaging, Thoracic Vertebrae / pathology, Tomography, X-Ray Computed, Treatment Outcome

Osteoid osteoma of the spine is a relatively rare bone-forming tumor. Pain that is worse at night and relieved by aspirin and muscle contracture are the most characteristic symptoms of spinal osteoid osteoma. Although radicular pain occasionally occurs in spinal osteoid osteoma, spinal cord and nerve root compression is absent in most cases. Although radicular pain appears to be associated with tumorous inflammation, there have been no presentations of histological findings of inflammation around the nerve root. We present here two rare cases of spinal osteoid osteoma causing radiculopathy and the first histological evidence of tumorous inflammation as a cause of radiculopathy in osteoid osteoma near the intervertebral foramen.
Treatment with mycophenolat mofetil of steroid-dependent asthma-one case of severe asthma
Authors: V Backer, E Hjardem, T Karlsmark
Journal: J Allergy (Cairo) (2009)
MeSH terms: Case Reports

Background. Some patients with severe nonallergic asthma can be difficult to treat with conventional therapy. Mycophenolat Mofetil (MMF) is an immunosuppressive drug with multiple mechanisms. There is theoretical support of specific effect of MMF on severe asthma, in "difficult to treat" patients. The aim of the present case was to explore whether MMF had an effect in one case of severe refractory asthma. The patient. This case deals with one patient with very severe nonallergic treatment refractory asthma who experienced treatment failure on ordinary antiasthmatic treatment and severe adverse events to conventional immunosupressive treatment. She was then treated with MMF. Results. The patient experienced a gain in FEV1 and a reduction in the need for oral glucocorticosteroids as well as seldom need of when needed bronchodilator both during daytime and night. It therefore seems very interesting to examine the use of MMF for severe refractory asthma with further clinical studies and basic cellular trials.
Anaphylactic reaction in patient allergic to mango
Authors: Natalia Ukleja-Sokołowska, Ewa Gawrońska-Ukleja, Kinga Lis, Magdalena Żbikowska-Gotz, Łukasz Sokołowski, Zbigniew Bartuzi
Journal: Allergy Asthma Clin Immunol (2018)
Keywords: allergy, art v 1, inhibition test, mango, mugwort
MeSH terms: Case Reports

Background:
An allergy to mango is extremely rare. The antigenic composition of the fruit is not fully known. Profilin from mango has a structure similar to birch tree profiling: it is responsible for cross-reactions between mango and pear, apple, and peach. A panallergen with a structure similar to mugwort defensin (Art v 1) which cross-reacts with celery, carrot, peanuts, pepper, aniseed, and caraway has been previously described.
Case study:
A female patient, 30 years old, was admitted in February 2017 because of recurrent allergic reactions following consumption of various foods. The most severe allergic reaction in the patient's life occurred after eating a mango fruit. Within several minutes the patient developed a generalised urticaria, followed by facial oedema, strong stomach pain and watery diarrhoea. The diagnostics involved skin tests with a set of inhalatory and food allergens, including native skin tests. The patient also experienced symptoms of recurrent, generalized urticaria in connection with consumption of various types of food, especially complex dishes containing many different ingredients. Additionally, an interview revealed that the patient was experiencing symptoms of the oral allergy syndrome after ingesting various fruit and vegetables, especially during late summer and fall. Diagnostics was extended by determining the levels of IgE specific for allergen components, using the ImmunoCap ISAC method. In order to confirm the occurence of a cross-reaction between mugwort and mango allergens, we performed the inhibition test of IgE specific for mugwort using a mango allergen extract and ImmunoCap matrix.
Results:
Skin prick tests (SPT) were positive for allergens of grass 7 mm; weeds 8 mm; cat's fur 5 mm; mugwort 6 mm. SPT were also positive for mango. The level of specific IgE was increased for allergens of mugwort, grass, celery, pepper, carrot, mango, banana, peach, and apple. The ImmunoCap ISAC test demonstrated a high level of specific IgE rPhl p 1 (timothy grass) and Art v 1 (mugwort). We also performed the IgE inhibition test using both mango extract and ImmunoCap matrix and confirmed a cross-reaction with Art v 1 in the pathogenesis of symptoms observed in the patient.
Conclusions:
An anaphylactic reaction to consumed mango, resulting from cross-allergy with mugwort Art v 1 was diagnosed in the patient. Acute urticarial in this case is a manifestation of IgE-mediated food allergy. During in vitro diagnostic procedures we found an elevated concentration of IgE specific to several food allergens (including celery, peppers, carrot, banana, peach, apple, shrimp). The elimination diet removing allergens the patient was allergic to was recommended. Considering the anaphylactic reaction the patient was instructed to carry a rescue set composed of an adrenaline autosyringe, steroids, and antihistamines.
Meconium Peritonitis, Intestinal Atresia Combined With Biliary Atresia: A Case Report
Authors: Yijiang Han, Shuqi Hu, Baohai Chen, Shoujiang Huang, Qi Qin, Jinfa Tou
Journal: Front Pediatr (2022)
Keywords: kasai, biliary atresia, intestinal atresia, meconium peritonitis, short bowel
MeSH terms: Case Reports

Meconium peritonitis (MP) combined with intestinal atresia (IA) is a rare neonatal condition, and it is even rarer in combination with biliary atresia (BA). We describe a case of an infant who developed short bowel syndrome after partial intestinal resection due to MP and IA, along with a Santullienterostomy. During continuous enteral and parenteral nutrition, the stool color became paler. BA was identified by elevated direct bilirubin (DBIL), gamma-glutamyltransferase (GGT), serum matrix metalloproteinase-7 (MMP-7), and hepatobiliary ultrasound; then, Kasai portoenterostomy (KPE) was performed promptly. The Roux-en-Y limb was adjusted intraoperatively to preserve the maximum length of the small intestine while closing the enterostomy. After the operation, the infant gradually adapted to enteral nutrition, his bilirubin level returned to normal, and his weight gradually caught up to the normal range. Although rare, BA should be suspected when MP is combined with IA and when the stool becomes paler in color in the enterostomy state.
Concurrent Occurrence of Tumor in Colon and Small Bowel following Intestinal Obstruction: A Case Report and Review of the Literature
Authors: Seyed Mohammad Reza Nejatollahi, Omid Etemad
Journal: Case Rep Surg (2016)

An intestinal obstruction occurs when either the small or large intestine is partly or completely blocked so it prevents passing the food or fluid through the small/large bowel. This blockage is due to the existence of a mechanical obstruction such as foreign material, mass, hernia, or volvulus. Common symptoms include cramping pain, nausea and vomiting, changes in bowel habits, inability to pass stool, and lack of gas. We present a case of an 83-year-old man who had been referred to Taleghani Hospital with symptoms of bowel obstruction. He underwent the surgery. The findings of exploration of the entire abdomen showed two types of mass separately in two different organs. In postoperative workup, pathology reported two types of tumors (adenocarcinoma and neuroendocrine tumors).
"He is suitable for her, of course he is our relative": a qualitative exploration of the drivers and implications of child marriage in Gezira State, Sudan
Authors: Laura Dean, Angela Obasi, Asma El Sony, Selma Fadul, Hanaa El Hassan, Rachael Thomson, Rachel Tolhurst
Journal: BMJ Glob Health (2019)
Keywords: child health, qualitative study

Introduction:
Child marriage is a fundamental development challenge for women and girls, with significant negative health and social outcomes. Sudan has a high rate of child marriage, with 34% of women aged 20-24 married before their 18th birthday. Since limited preventive interventions exist, we aimed to inform the evidence base to strengthen strategic action, using mixed qualitative methods to enhance study credibility. This study is the first to conduct a rigorous qualitative examination of the drivers of child marriage from the perspective of key stakeholders involved in marriage decision making within Sudan, and makes a significant contribution towards global knowledge by developing an evidence-based conceptual framework.
Methods:
Initially, we completed 14 focus group discussions separated by gender with mothers, fathers, and girls married as adolescents, and 23 key informant interviews. We then used a critical incident case study approach to explore 11 'cases' of child marriage (46 interviews).
Results:
Findings indicate that gendered social norms and values, underpinned by religious beliefs and educational accessibility, interconnect to shape marriage decisions. In this context, many child marriages are triggered by an intrakinship proposal and further enabled by the relative lack of autonomy and influence of girls and women in marriage decision-making processes.
Discussion:
Interconnected drivers demand context-specific holistic and multisectoral approaches, which should include simultaneous strategies to expand access to education, health services and livelihood opportunities, and evoke legal change, and participatory social and attitudinal processes that include the engagement of religious leaders and men.
Klebsiella pneumoniae endogenous endophthalmitis presenting as orbital cellulitis
Authors: Benjamin Kambiz Ghiam, Paul Israelsen, Angeline Wang, Seanna Grob, Mohammad Riazi Esfahani
Journal: GMS Ophthalmol Cases (2019)
Keywords: klebsiella pneumoniae, endogenous endophthalmitis, liver abscess, orbital cellulitis
MeSH terms: Case Reports

This report describes the first documented case of Klebsiella pneumoniae endogenous endophthalmitis with concurrent orbital cellulitis in a patient without a liver abscess. A 34-year-old, caucasian male with a history of intravenous drug abuse and type 1 diabetes mellitus was transferred from an outside hospital for progressively worsening pain and swelling in the right eye. Careful history, physical examination, and imaging were consistent with a diagnosis of endogenous endophthalmitis with concurrent orbital cellulitis. Vitreous cultures were positive for Klebsiella pneumoniae. Despite aggressive and early intervention with antibiotics and vitrectomy, the patient's condition continued to worsen and evisceration was required to adequately control the infection. Klebsiella pneumoniae endogenous endophthalmitis with concurrent orbital cellulitis is a rare and often blinding infection, despite appropriately aggressive intervention.
Reconstruction with a free temporoparietal fascia flap for intractable flexor tenosynovitis of the wrist accompanied by a soft tissue defect: a case report
Authors: Atsuhiko Iwao, Katsumi Tanaka, Akihito Higashi, Hiroto Saijo, Kazuya Kashiyama
Journal: Case Reports Plast Surg Hand Surg (2021)
Keywords: flexor tenosynovitis, soft tissue defect, temporoparietal fascia flap
MeSH terms: Case Reports

We herein report a case of intractable flexor tenosynovitis. The inflamed synovium was debrided twice because of suspected infectious tenosynovitis. However, it relapsed and caused a soft tissue defect. Reconstruction with a free temporoparietal fascia (TPF) flap was performed. Recurrence has not been detected in the six years after surgery.
Space Regaining Made Easy: The Case of a Severely Infraoccluded Primary Molar
Authors: Daniele Garcovich, Riccardo Aiuto, Milagros Adobes Martin
Journal: Case Rep Dent (2019)
MeSH terms: Case Reports

Infraocclusion of deciduous molars is a quite common but challenging clinical situation that a paediatric dentist has to face in his everyday practice. This anomaly can lead to space loss, eruption disturbances of the permanent successor, and deformation of the occlusal plane. A case of a severely infraoccluded primary molar is presented. The treatment was carried out using a compressed NiTi wire applied only to the adjacent teeth. In three months, the space was recovered, and the infraoccluded temporary molar was extracted. After one year, the permanent successor erupted without any complication. The technique presented can be considered minimally invasive, and it involves cost- and time-efficient mechanics.
When Left Is Right and Right Is Wrong: A Case Report of Two Near-Miss Wrong-Sided Peripheral Nerve Blocks
Authors: Alexander M DeLeon, Alexander G Samworth, Bashar F Kazanji
Journal: Case Rep Anesthesiol (2022)
MeSH terms: Case Reports

Wrong-sided peripheral nerve blocks occur with a surprisingly high frequency despite being described as a "never event." Timeout procedures are performed and documented, yet timeout omission is rarely cited as a contributing factor for wrong-sided blocks. We present two cases of near-miss wrong-sided peripheral nerve blocks and provide recommendations based on the current literature and the most common contributing factors.
Cabazitaxel Induced Thrombotic Microangiopathy in a Patient with Prostate Cancer
Authors: Yannick Nlandu, Franck Pourcine, Ly van Phach Vong, Jonathan Chelly, Sebastien Jochmans, Sandie Mazerand, Mehran Monchi
Journal: Case Rep Nephrol (2019)
MeSH terms: Case Reports

Cancer-associated thrombotic microangiopathy (TMA) refers to a group of disorders characterized by microangiopathic haemolytic anemia, thrombocytopenia, and ischemic organ damage. TMA manifestations can be induced by cancer or by chemotherapy. We report the case of a 64-year-old man with metastatic prostate cancer who experienced a Cabazitaxel-induced TMA manifestation. TMA responds to conservative therapy, dialysis without plasmaphoresis, with progressive recovered renal function.
A rare complication of pulmonary tuberculosis - Pulmonary venous thrombosis with atrial extension
Authors: Onkar Balasaheb Auti, Ranganath R, Murali Mohan Bv, Vimal Raj
Journal: J Cardiovasc Thorac Res (2017)
Keywords: complications of pulmonary tb, pulmonary venous thrombosis, tuberculosis
MeSH terms: Case Reports

Pulmonary tuberculosis (TB) is serious public health problem in India and worldwide. The mortality rate in pulmonary TB is high in those with advanced disease and in presence of complications. It presents with wide variety of complications of which haematological complications are rare. Many cases were reported pulmonary TB associated with deep venous thrombosis, hepatic and portal venous thrombosis, central retinal venous thrombosis and sagittal sinus thrombosis in TB meningitis. We report a rare case of pulmonary TB with pulmonary venous thrombosis and atrial extension. To our best knowledge, this is the first case reported of its kind.