OpenMed/multicare-articles huggingface dataset:
Nasopharyngeal tuberculosis: A case report
Authors: Yang Yang, Yuan Fang, GuoNing Yang
Journal: Open Life Sci (2022)
Keywords: histopathology, nasopharynx, sore throat, tuberculosis
MeSH terms: Case Reports

Nasopharyngeal tuberculosis is a rare disease. Even in areas where tuberculosis is endemic, its incidence is also extremely low. Here, we will report a rare case of nasopharyngeal tuberculosis. A 29-year-old male patient presented with a 2-month history of sore throat, nasal congestion, dysphagia, and low-grade fever. Thickened mucosa in the posterior wall of the nasopharynx was shown from nasopharyngoscopy, covered with a thick, yellowish, purulent secretion that was not easily removed. Computed tomography of the nasopharynx showed thickening of the mucosa in the right and left bilateral walls and the posterior wall with indistinct margins. Histopathological examination diagnosed nasopharyngeal tuberculosis granuloma. Nasopharyngeal tuberculosis is rare and has atypical symptoms. When a new organism appears in the nasopharynx, it should be differentiated from tuberculosis, autoimmune diseases, and tumors, and a tissue biopsy of the new organism should be performed to make a final diagnosis based on histopathology.
Pulmonary embolism caused by ovarian vein thrombosis during cesarean section: a case report
Authors: Yutaka Oda, Michie Fujita, Chika Motohisa, Shinichi Nakata, Motoko Shimada, Ryushi Komatsu
Journal: JA Clin Rep (2018)
Keywords: cesarean section, ovarian vein thrombosis, pulmonary embolism

Background:
Ovarian vein thrombosis is a rare complication of pregnancy. The representative complaints of patients with ovarian vein thrombosis are abdominal pain and fever. In some cases, however, fatal pulmonary embolism may develop. We report a case of pulmonary embolism presenting with severe hypotension and loss of consciousness during cesarean section possibly caused by ovarian vein thrombosis.
Case presentation:
A 25-year-old woman at 38 weeks 4 days of gestation was scheduled for repeat cesarean section. Her past history was unremarkable, and the progress of her pregnancy was uneventful. She did not experience any symptoms indicative of deep vein thrombosis. Cesarean section was performed under spinal anesthesia, and a healthy newborn was delivered. After removal of the placenta, she suddenly developed dyspnea, hypotension, and loss of consciousness with decreased peripheral oxygen saturation. Blood pressure, heart rate, and oxygen saturation recovered after tracheal intubation and mechanical ventilation with oxygen. Postoperative computed tomography revealed no abnormality in the brain or in the pulmonary artery, but a dilated right ovarian vein with thrombi, extending up to the inferior vena cava, was found. A diagnosis of pulmonary embolism caused by ovarian vein thrombosis was made, and heparin was administered. The tracheal tube was removed on the first postoperative day. Her postoperative course was uneventful, and she was discharged with no complications.
Conclusion:
Fatal pulmonary embolism might be caused by ovarian vein thrombosis during cesarean section. Careful and continuous observation of the patient after delivery and prompt treatment are important.
Granulocytic sarcoma in a nonleukemic patient: place of radiotherapy and systemic therapies
Authors: C Chargari, J Jacob, O Bauduceau, F R Ferrand, T De Revel, L Védrine
Journal: Case Rep Med (2011)
MeSH terms: Case Reports

Granulocytic sarcoma is a rare extramedullary tumour, which most often occurs in the course of an acute or chronic leukaemia or myeloproliferative disorders. Rarely it is found before peripheral blood or bone marrow evidence of leukemia is present. We report an unusual case of acute paraplegia at first presentation of a spinal epidural granulocytic sarcoma without any haematological disorder. Therapeutic strategies are discussed in the light of the literature.
Case report: Identification of atypical mantle cell lymphoma with CCND3 rearrangement by next-generation sequencing
Authors: Luomengjia Dai, Han Zhang, Wen Chen, Yi Xia, Shuchao Qin, Yang Shao, Jianyong Li, Yi Miao, Bingzong Li, Huayuan Zhu
Journal: Front Oncol (2023)
Keywords: ccnd3 rearrangement, ngs, diagnosis, fusion gene, mantle cell lymphoma
MeSH terms: Case Reports

The t(11;14) (q13;q32) translocation resulting in overexpression of cyclin D1 is the major oncogenic mechanism in mantle cell lymphoma (MCL). Most MCLs can be diagnosed based on morphological features, cyclin D1 expression, and IGH/CCND1 rearrangement. However, in some atypical cases where conventional FISH studies fail to detect IGH/CCND1 rearrangement or immunohistochemistry for cyclin D1 is negative, the diagnosis of the disease can be difficult. Hence, next-generation sequencing (NGS) may allow the identification of molecular alterations and assist in the diagnosis of atypical MCL. In this study, we reported a case of a patient diagnosed as asymptomatic MCL who presented with lymphadenopathy during the initial assessment. A lymph node biopsy was performed and the results revealed a high Ki67 index. However, initial diagnosis of aggressive MCL was difficult since the IGH/CCND1 rearrangement result was negative. Ultimately, by the aid of NGS we identified a rare CCND3 rearrangement in the patient, which lead to overexpression of cyclin D3, thereby facilitating the diagnosis of MCL.
A Case Report: Mucinous Tubular and Spindle Cell Carcinoma of Kidney with Spindle Cell Predominance Mimicking Mesenchymal Tumour
Authors: Natarajan Ramya, Murhekar Kanchan, Raja Anand, Sundersingh Shirley
Journal: J Kidney Cancer VHL (2022)
Keywords: mesenchymal tumour, mucinous tubular and spindle cell carcinoma, rare variant, renal cell carcinoma, spindle cell predominance
MeSH terms: Case Reports

Mucinous tubular and spindle cell carcinoma (MTSCC) of kidney is a rare variant of renal cell carcinoma which was first described in the 2004 World Health Organization classification of tumours of the kidney. Morphologically, MTSCC is composed of tubules merging with bland-appearing spindle cells in a myxoid/mucinous stroma. Diverse morphological patterns have been reported in MTSCC; however, a spindle cell predominant morphology mimicking a mesenchymal tumour is rare and only two cases have been reported so far. We report a case of MTSCC with spindle cell predominance in kidney which was a diagnostic challenge. Though MTSCC usually shows an indolent course, there have been cases showing aggressive behaviour even with bland morphology. Hence, a thorough histopathological evaluation with ancillary studies are required to differentiate spindle cell predominant MTSCC from its mimics. Our case was a 40-year-old female who was incidentally found to have a well-defined hypodense lesion measuring around 2 cm in the upper pole of the right kidney. Right partial nephrectomy was performed which showed a 2.7 × 2.5 × 2 cm well-defined grey tan tumour without necrosis or haemorrhage, limited to kidney. Histopathological examination showed sheets of bland-appearing spindle cells mimicking a mesenchymal tumour. The tumour was extensively sampled, revealing small foci of tubule formation and mucinous stroma. Tumour cells were positive for CK7, AMACR, and PAX8. A final diagnosis of MTSCC was made. Hereby, we discuss ways of differentiating MTSCC from other spindle cell tumours of the kidney.
A Case of Vaginal Birth after Cesarean Delivery in a Patient with Uterine Didelphys
Authors: Jennifer W H Wong
Journal: Case Rep Obstet Gynecol (2019)
MeSH terms: Case Reports

Background:
The American College of Obstetricians and Gynecologists (ACOG) recommends that most women with one prior low-transverse cesarean delivery should be offered a trial of labor after cesarean (TOLAC). However, very little is known about TOLAC in women with uterine anomalies.
Case:
A 32-year-old gravida-2 para-1 female with a history of uterine didelphys and one prior low-transverse cesarean section in the left uterine horn presented with a subsequent pregnancy in the left uterine horn. After extensive counseling on TOLAC versus repeat cesarean delivery, the patient decided to proceed with TOLAC and had a spontaneous vaginal delivery of a healthy infant at 38 3/7 weeks of gestation.
Conclusion:
TOLAC can be considered in women with uterine anomalies using ACOG's standard TOLAC guidelines with informed consent and shared decision-making between the patient and obstetrician.
Fibromatosis of the hand associated with EMO syndrome: a case report
Authors: Carolin Appelhans, Frank Breuckmann, Andreas Bastian, Peter Altmeyer, Alexander Kreuter
Journal: BMC Dermatol (2004)
MeSH terms: Exophthalmos / complications, Fibroma / complications, Hand, Leg Dermatoses / complications, Myxedema / complications, Osteoarthropathy, Primary Hypertrophic / complications, Case Reports, Humans, Hyperthyroidism / complications, Male, Middle Aged, Syndrome

Background:
EMO syndrome, defined as a triad including exophthalmus, pretibial myxedema and osteoarthropathia, is a rare condition in patients suffering from hyperthyreosis.
Case presentation:
We here describe an interesting case of EMO syndrome associated with unilateral fibromatosis of the hand and an initial stage of generalized myxedema of the skin. To our knowledge a similar case has not yet been described in literature though reports about associated fibromatosis, e.g. located retroperitoneally, already exist. Familiar explanations include its initiation by autoimmune processes or aberrant T-cell cytokine stimulation leading to an overwhelming production of glycosaminoglycans.
Conclusion:
Interpreting our case in context with previous reports we conclude that associated fibromatosis induced by autoimmune processes may affect a variety of different localizations and therefore requires careful monitoring. A therapeutical attempt by using UVA1 irridation for pretibial myxedema remained without a satisfying regression.
Hemangioblastoma in the lateral ventricle: An extremely rare case report
Authors: Ruihan Pan, Jianwei Shi, Yang Xu, Fuduo Bo, Zhengxiang Luo, Yansong Zhang
Journal: Front Oncol (2022)
Keywords: case report, hemangioblastoma, lateral ventricle, magnetic resonance imaging, neurosurgery
MeSH terms: Case Reports

Hemangioblastoma (HB) is a benign vascular tumor that accounts for approximately 2% of intracranial neoplasms. HB of the lateral ventricles is extremely rare. Only a few reports are present in the literature. This article reports a 27-year-old male patient who arrived at our hospital because of a progressive headache lasting one month. The brain Magnetic Resonance Imaging (MRI) revealed a solid-cystic mass of 3.5×3.0 cm in size located in the left lateral ventricle, the surgery was performed by applying an interhemispheric approach to single frontal craniotomy with coronal incision to remove the tumor. The postoperative CT and MRI showed the successful complete removal of the tumor and a normal ventricle morphology. The differential diagnosis should be considered in case of intraventricular tumors including HB. Angiography should be performed prior to surgery when HB is suspected.
A New Challenging Strategy in the Prevention and Management of Tumor Lysis Syndrome in Patients with Chemo-Sensitive Hematological Malignancies
Authors: Ammar ELJack, Mohamad El Abdallah, Kadhim Al-Banaa, Kashif Chaudhry, Faisal Musa
Journal: Case Rep Oncol Med (2019)
MeSH terms: Case Reports

Introduction:
Tumor lysis syndrome (TLS) is a metabolic derangement that results from rapid destruction of cells. It happens frequently in cancers receiving chemotherapy, particularly hematological malignancies. It can lead to death in severe cases. Tumor lysis syndrome that leads to acute renal failure requiring dialysis and/or ICU admission can be associated with a higher rate of complications and mortality.
Case report:
We present a 24-year-old male patient with Burkitt's lymphoma. After receiving one cycle therapy, he developed severe kidney injury from TLS. We initiated renal replacement therapy soon after his admission to the ICU, with marked response to therapy. This led to early discharge from the ICU.
Conclusion:
Early initiation of renal replacement therapy after TLS-AKI can improve the severity of AKI and hasten recovery and prevent complications. This can lead to earlier discharge from the hospital and better outcomes.
A Case of Early Calciphylaxis Diagnosed by Bone Scan
Authors: Jia Di, Yuqiu Liu, Dongyan Wang, Min Yang
Journal: Case Rep Med (2020)
MeSH terms: Case Reports

Calcium uremic aortic disease (calciphylaxis) has long been considered as a rare, life-threatening small vessel disease. The diagnosis of calciphylaxis depends mainly on clinical symptoms and high risk factors, and skin biopsy can be used to confirm the diagnosis. However, noninvasive testing methods are still the focus of exploration currently. There is increasing evidence that bone scintigraphy is helpful in the diagnosis of calciphylaxis, especially for assessing the involvement of muscles and internal organs. Here, we describe a pathology-proven case of calciphylaxis case and the corresponding imaging findings on Tc-99 m MDP bone scan imaging.
Microsurgical reconstruction of the enormous traumatic oromandibular defect by osteocutaneous fibula-free flap in a 9-year-old child: a case report
Authors: Abdulfattah Altam, Saleh Alredae, Ahmed Alsaaidi, Faisal Ahmed, Waleed Aljbri, Burkan Nasr, Qasem Alyhari, Abdullah Al-Nagga
Journal: Pan Afr Med J (2022)
Keywords: oromandibular defect, case report, children, microsurgery, osteocutaneous fibula-free flap
MeSH terms: Free Tissue Flaps, Case Reports, Child, Esthetics, Family, Humans, Lip, Tracheostomy

Enormous oromandibular defects in children remain a reconstructive challenge due to the region's unique features and the scarcity of a perfectly matched recipient site. The osteocutaneous fibula-free flap (OCFFF) is an excellent option for these defects. Most reports on oromandibular reconstruction in children are limited to surgical techniques instead of long-term follow-up, especially in resource-limited settings. We reported a 9-year-old child who presented with a massive oromandibular defect caused by a high-energy gunshot. Firstly, the patient was treated with debridement, lower defect edges approximation, and tracheostomy. After one week, the procedure of OCFFF was performed, and two months later, the lower lip was reconstructed using a tongue flap. The aesthetic outcome was excellent at two years, and the patient could speak and eat without impaired oral function. In conclusion, microsurgical reconstruction using OCFFF for massive oromandibular defects in our child patient was safe with satisfactory facial aesthetics and oral function.
Human parvovirus B19 infection in a pregnant patient resulting in severe hydrops, foetal death and persistent infection
Authors: Ariel Bertoldi, María Belén Colazo Salbetti, Gonzalo Rodríguez, Magdalena Tenaglia, Gabriela Hernández, Jimena Alfaro, María Inés Riberi, Nicolás Lionel Olivera, Mauro Pedranti, María Beatriz Isa, Maria Pilar Adamo
Journal: Access Microbiol (2022)
Keywords: viremia, congenital diagnosis, congenital hypoplastic anemia, non-immune hydrops fetalis, serological tests
MeSH terms: Case Reports

Human parvovirus B19 (B19V) is the aetiological agent of erythema infectiosum. Primary infection during pregnancy can be transmitted to the foetus and cause foetal abnormalities related to depletion of erythrocyte progenitor cells, including congenital anaemia, hydrops, and foetal death. In this paper we report the detection of B19V infection in a pregnant patient, which onset occurred without appreciable signs and symptoms until she developed inappropriate contractions for gestational age and fluid loss. B19V infection resulted in severe hydrops fetalis with a fatal course for the foetus, while persisted in the mother at least 12 months after foetal death. The objective of this report is to highlight the importance of optimizing B19V diagnosis through early suspicion and testing during pregnancy. Knowing the mother's immune status before or at the beginning of gestation can contribute, together with early diagnosis, to improve the management of patients at risk.
Neovessel as first manifestation of relapse of associated multifocal choroiditis and MEWDS
Authors: Eduardo Morizot, Camila Schiavo Froner
Journal: Int J Retina Vitreous (2019)
Keywords: mewds, multifocal choroiditis, neovascularization
MeSH terms: Case Reports

Purpose:
To report a case of multifocal choroiditis (MC) that has relapsed as choroidal neovascularization in the contralateral eye followed by a mixed aspect of multiple evanescent white dot syndrome (MEWDS) and MC.
Methods:
Retrospective case report and literature review. The clinical findings were documented by fluorescein angiography, optical coherence tomography, and optical coherence tomography angiography (OCT-A).
Results:
The authors describe the case of a 39-year-old woman with prior ocular history of presumed MEWDS in her left eye, which developed into MC 7 years later in the same eye and 11 years later in the right eye, starting as choroidal neovascularization and developing into MEWDS. OCT-A showed neovessel in a supposedly active MC area outside the macular region in right and left eyes. OCT showed increased choroidal thickness in both eyes and a choroidal neovascularization in the right eye, treated using anti- VEGF therapy.
Conclusion:
This case corroborates the proximity of some inflammatory diseases such as MC and MEWDS. OCT-A has opened new horizons for the better understanding of some retinal diseases by providing more thorough and promising morphological analyses using enhanced tools.
The value of the multidisciplinary team in metastatic renal cell carcinoma: Paving the way for precision medicine in toxicities management
Authors: Michela Roberto, Martina Panebianco, Anna Maria Aschelter, Dorelsa Buccilli, Carmen Cantisani, Salvatore Caponnetto, Enrico Cortesi, Sara d'Amuri, Claudia Fofi, Debora Ierinò, Viviana Maestrini, Paolo Marchetti, Massimo Marignani, Antonio Stigliano, Luca Vivona, Daniele Santini, Silverio Tomao
Journal: Front Oncol (2023)
Keywords: cardiovascular toxicity, cutaneous toxicity, endocrinological toxicity, liver toxicity, metastatic renal cell carcinoma (mrcc), multidisciplinary team (mdt), nephrological toxicity
MeSH terms: Review

The new landscape of treatments for metastatic clear cell renal carcinoma (mRCC) is constantly expanding, but it is associated with the emergence of novel toxicities, adding to up to those observed in the tyrosine-kinase inhibitor (TKI) era. Indeed, the introduction of immune checkpoint inhibitors (ICIs) alone or in combination has been associated with the development of immune-related adverse events (irAEs) involving multiple-organ systems which, even if rarely, had led to fatal outcomes. Moreover, due to the relatively recent addition of ICIs to the previously available treatments, the potential additive adverse effects of these combinations are still unknown. A prompt recognition and management of these toxicities currently represents a fundamental issue in oncology, since it correlates with the outcome of cancer patients. Even if clinical guidelines provide indications for the management of irAEs, no specific protocol to evaluate the individual risk of developing an adverse event during therapy is currently available. A multidisciplinary approach addressing appropriate interventions aimed at reducing the risk of any insidious, severe, and/or dose-limiting toxicity might represent the most efficacious strategy to timely prevent and manage severe irAEs, allowing indirectly to improve both patients' cancer-specific survival and quality of life. In this review, we reported a five-case series of toxicity events that occurred at our center during treatment for mRCC followed by the remarks of physicians from different specialties, pinpointing the relevant role of an integrated and extended multidisciplinary team in a modern model of mRCC patient management.
Her2 Status Discrepancy Between Core Needle Biopsy and Surgically Resected Mastectomy Specimen: A Clinical Case
Authors: Ana Carolina Vasques Sr, Mafalda Miranda Baleiras, Marta Pinto, Filipa Ferreira, Ana Martins
Journal: Cureus (2023)
Keywords: biomarker, breast cancer, concordance, her2, intratumoral heterogeneity
MeSH terms: Case Reports

The biomarker concordance between core needle biopsy (CNB) and surgical specimen (SS), in breast cancer, has long been a matter of discussion because of its influence on oncologic treatment choice. Particularly, human epidermal growth factor receptor 2 (Her2) status is quite important, because of the impact on breast cancer classification and target therapy. Many factors could influence the difference in biomarker status between samples, such as the technic itself, sample procedures and intratumoral heterogeneity. Neoadjuvant chemotherapy (NAC) can also contribute to this variation and should be taken into consideration. We report a clinical case of a 33-year-old man who was diagnosed with right breast cancer, initially Her2 negative in the CNB. Therefore, the NAC was completed without anti-Her2 treatment. Later, after the mastectomy, revision of the SS was found to be positive for Her2, after the silver in situ hybridization (SISH) technique. Consequently, the patient lost the chance of doing anti-Her2 therapy in the neoadjuvant setting, reducing his possibility to achieve a complete pathologic response and later jeopardizing his clinical outcome.
Onycholysis an early indicator of thyroid disease
Authors: Malumani Malan, Zhe Dai, Wu Jianbo, Song Ji Quan
Journal: Pan Afr Med J (2019)
Keywords: graves´ disease, onycholysis, hyperthyroidism, hypothyroidism, plummer´s nails, thyroid disease
MeSH terms: Graves Disease / diagnosis, Hyperthyroidism / diagnosis, Onycholysis / etiology, Case Reports, Adult, Graves Disease / complications, Humans, Hyperthyroidism / complications, Male, Onycholysis / diagnosis, Prognosis

Onycholysis is also referred to plummer's nails is a dermatological nail disorder characterized by spontaneous distal separation of the nail plate from the free margin and progressively proximally. We discuss a case of the 38-year-old man with onycholysis associated with hyperthyroidism due to Graves' disease. In this case review, we will discuss an association of onycholysis with thyroid disease and its diagnostic prognosis. Any unexplained onycholysis should prompt the clinician to investigate the client for asymptomatic hyperthyroidism.
Bilateral Primary Total Knee Arthroplasty and Reconstruction of the Medial Tibial Plateau by an Asymmetric Cone in a Patient with Charcot Arthropathy
Authors: Spiros Tsamassiotis, Henning Windhagen, Max Ettinger
Journal: Case Rep Surg (2021)
MeSH terms: Case Reports

Charcot arthropathy of the knee is an extremely rare orthopedic disease that is very challenging for the treating physician and is associated with many complications, especially if it is occurring on both knees. Meanwhile, in the advanced stage, despite many potential complications, TKA is recognized as the gold standard. However, destruction of the medial tibial plateau is typical for the disease, which makes a stable anchorage of the prosthesis much more difficult. Therefore, we present a case in which sufficient primary stability could be achieved with an asymmetrical second-generation tibial cone with an anatomical design and implantation instruments adapted to the bony anatomy in the presence of severe tibial destruction on both sides. In the two-year follow-up, the patient showed good mobility and stability on both sides. In advanced Charcot arthropathy of the knee, the use of asymmetric tibial cones appears to be an appropriate solution for secure fixation and stability of the implant.