OpenMed/multicare-articles huggingface dataset:
Migraine with aura in the locker room: three case reports
Authors: Ilenia Corbelli, Cataldo D'Amore, Stefano Caproni, Gabriela Cardaioli, Paolo Calabresi, Paola Sarchielli
Journal: J Headache Pain (2012)
MeSH terms: Exercise, Football, Migraine with Aura / etiology, Case Reports, Adult, Brain Diseases / diagnosis, Diagnosis, Differential, Humans, Male, Migraine with Aura / diagnosis, Young Adult

It is well known that physical activity can aggravate the intensity of the headache, but the pathophysiological relationship between exertion and aura is still unknown. Anecdotal reports describe episodes of migraine preceded by head trauma and visual symptoms, migraine prodrome symptoms after unusually strenuous running with no subsequent head pain or recurrent attacks of hemiplegic migraine induced only by exertion. We describe the cases of three young men with recurrent episodes of migraine with aura occurring in the locker room shortly after a football match. Since the symptoms could mimic important pathologies in approximately 10% of these of headaches, it was mandatory to exclude a secondary form of headache in these patients. Several theories exist regarding the cause of primary exertional headache, but the pathogenesis of migraine triggered by physical activity has still not been identified. The present International Classification of Headache Disorders does not mention sport/exercise-induced migraine with aura episodes as primary headache. Since there are many cases described in the literature of migraine with aura triggered only by exercise, it may be helpful to specify, in the typical aura with migraine headache comments, that in some cases it can be exclusively triggered by sport/exercise.
Vulvovaginal Infralevator Haematoma Mimicking the Second Stage of Labour
Authors: J O Awoleke, O M Ipinnimo
Journal: Case Rep Obstet Gynecol (2017)
MeSH terms: Case Reports

Even though they are quite uncommon, puerperal genital haematomas can be associated with serious maternal morbidity. Key findings are significant perineal pain and, depending on the location, visible swelling. However, attention can be drawn to its progression by the rare occurrence of persistent painful "bearing down" efforts, even after the successful delivery of the baby. The final size of this haematoma and the rare presentation make it truly uncommon. The primary goals of treatment include the prevention of further blood loss, minimizing tissue damage, relieving pain, and reducing the risk of infection. Management is generally conservative for small collections, but surgery is indispensable when they acutely expand in size or are large with worsening symptoms.
Idiopathic radiation recall dermatitis developing nine months after cessation of Cisplatin therapy in treatment of squamous cell carcinoma of the tonsil
Authors: Stephen M Melnyk, Kenneth F More, Edward F Miles
Journal: Case Rep Oncol Med (2012)
MeSH terms: Case Reports

To report on a suspected case of idiopathic radiation recall dermatitis in an individual nine months after radiation and chemotherapy treatment of squamous cell carcinoma of the right tonsil. Radiation recall dermatitis is the development of a reaction in a previously irradiated area of skin after the administration of an aggravating medication. A review of the literature revealed several cases of radiation recall dermatitis that occur following radiation therapy and the institution of chemotherapy. Other medications have also been implicated in radiation recall dermatitis; however, this patient has not started any new medications since completion of his combined therapy. The patient developed this skin reaction in a distribution pattern identical to the area that received the highest radiation dose suggesting a possible link between radiation recall dermatitis and radiation dose. Radiation recall dermatitis is a reaction that is typically seen shortly after the reinstitution of chemotherapy during radiation therapy. This case illustrates that other medical etiologies are possible and suggests a relationship between radiation recall dermatitis and the total radiation dose an area receives.
Unusual Case of Osseointegrated Dental Implant Migration into Maxillary Sinus Removed 12 Years after Insertion
Authors: Mauro Laureti, Nicola Ferrigno, Daniele Rosella, Piero Papi, Francesca Mencio, Francesca De Angelis, Giorgio Pompa, Stefano Di Carlo
Journal: Case Rep Dent (2017)
MeSH terms: Case Reports

Displacement of dental implants into the maxillary sinus is not an uncommon event in implant dentistry and may lead to serious complications, such as sinusitis. To avoid systemic problems, performing the removal of the foreign body as soon as possible is suggested. Despite the fact that early implants dislocation has been reported several times, late migration into maxillary sinus has been described by just a few studies. The purpose of this study was to report a rare case of dental implant migration into maxillary sinus after 12 years of function. A 61-year-old woman came to our attention in June 2015 after being visited by an otolaryngologist and being diagnosed with sinusitis and presence of a foreign body into the right maxillary sinus. A panoramic radiograph and a CT scan showed the migration of dental implant sited in 1.6 positions into the maxillary sinus. The implant was removed following a Caldwell-Luc procedure under local anesthesia. Postoperative course was uncomplicated and the patient reported no symptoms of sinusitis after 12 months of follow-up.
Diffuse B Cell Non-Hodgkin's Lymphoma Presenting Atypically as Periprosthetic Joint Infection in a Total Hip Replacement
Authors: Aysha Rajeev, Angela Ralte, Nameer Choudhry, Faizan Jabbar, Paul Banaszkiewicz
Journal: Case Rep Orthop (2017)
MeSH terms: Case Reports

The occurrence of extranodal primary B cell non-Hodgkin's lymphoma is rare. Total hip replacement is one of the most common orthopaedic procedures performed. There has been an increased incidence of primary lymphomas involving periprosthetic sites. Chronic inflammation due to metal debris arising from the prosthetic implants has been evidenced as one of the causes for the development of soft tissue lymphomas albeit rarely. We describe a case report of a 77-year-old patient who had underwent a cemented total hip replacement in the past who further developed large B cell primary non-Hodgkin's lymphoma. She presented initially with signs and symptoms highly suggestive of underlying periprosthetic infection. The radiological imaging was also indicative of periprosthetic infection. The diagnosis was eventually confirmed after an open biopsy. This case underlines the importance of considering and including soft tissue malignancy in the differential diagnosis of suspected chronic periprosthetic infection.
The Role of EGFR Inhibitors in the Treatment of Metastatic Anal Canal Carcinoma: A Case Series
Authors: Muhammad W Saif, Ewa Kontny, Kostas N Syrigos, Armin Shahrokni
Journal: J Oncol (2011)
MeSH terms: Case Reports

Anal cancer patients who have exhibited disease progression after having received all approved drugs pose a major therapeutic challenge. In addition to cytotoxic agents, novel targeted agents are being developed and have an established role in the treatment of many solid tumors, including colon cancer. However, their role in anal cancer is yet to be determined. Most anal malignancies are squamous cell carcinomas often strongly expressing epidermal growth factor receptors (EGFRs). Targeting the latter seems to result in favorable changes in tumor growth. We present three cases of refractory anal cancers, treated with EGFR inhibitors, after having received the recommended chemotherapy regimens. We conclude that EGFR inhibitors may play a vital role in the treatment of anal cancer and we suggest that large trials are be conducted in order to clarify their efficacy and to improve therapeutic management.
The Malignant Obstruction Caused by Pancreatic Cancer Within the Uncinate Process in the Third Portion of the Duodenum
Authors: Teruaki Inoue
Journal: Cureus (2023)
Keywords: duodenal obstruction, pancreatic head cancer, self-expandable metal stent, third portion of the duodenum, uncinate process cancer
MeSH terms: Case Reports

Pancreatic cancer has a poor prognosis, and it often causes duodenal obstruction and obstructive jaundice associated with tumor invasion. Self-expandable metal stent (SEMS) placement is useful for duodenal obstruction. Pancreatic cancer can occur in the uncinate process, which may lead to malignant obstruction in the third portion of the duodenum. However, the upper gastrointestinal endoscope often cannot reach the third portion of the duodenum, and SEMS placement is sometimes difficult. We report a case of successful SEMS placement with a colonoscope for the obstruction of the third portion of the duodenum due to uncinate process cancer. A 67-year-old Japanese male was referred to our hospital for palliative treatment of unresectable pancreatic cancer. He complained of anorexia and vomiting and was admitted to our hospital. Computed tomography (CT) scans showed the tumor with delayed enhancement in the pancreatic uncinate process. Esophagogastroduodenoscopy (EGD) and gastrografin enema revealed the stenosis caused by tumor invasion in the third portion of the duodenum. The stenosis was thought to cause his symptom. PCFQ260AZ endoscope (Olympus, Tokyo, Japan) was able to reach the stenosis, and a 22 mm × 80 mm uncovered SEMS (Niti-S, Taewoong Medical, Seoul, South Korea) was placed beyond the stenosis. After SEMS placement, his symptoms disappeared. Uncinate process cancer is located close to the third portion of the duodenum and caused the obstruction there. We should be cautious about this, and a colonoscope is useful for SEMS placement for malignant obstruction in the third portion of the duodenum.
No aggression in a 4-year-old boy with an androgen-producing tumour: case report
Authors: Wouter De la Marche, Karin Prinsen, Annemieke M Boot, Robert F Ferdinand
Journal: Ann Gen Psychiatry (2005)

Background:
The androgen testosterone plays a critical role in many aspects of sexual differentiation. Also, it is thought to induce aggressive behaviours or to play a role in social dominance.
Case presentation:
In this case report a 4-year-old boy is described whose testosterone and dehydroepiandrosterone sulphate (DHEA-S) levels were raised to pubertal levels due to a testosterone producing testis tumour. This provided the unique opportunity to examine the effects of elevated levels of androgens on levels of aggression or on social dominance before the onset of puberty.
Conclusion:
The present case report does not support the hypothesis of a causal relationship between testosterone and aggression or between testosterone and social dominance in young children.
Primary Renal Lymphoma Presenting as End-Stage Renal Disease
Authors: Lavjay Butani, Jonathan Ducore
Journal: Case Rep Med (2017)
MeSH terms: Case Reports

Primary renal lymphoma is a rare entity, even more so in children. Children with primary renal lymphoma present with variable clinical features such as constitutional signs and symptoms, acute kidney injury, palpable abdominal masses, and gross hematuria. Herein we report a child who presented with seemingly advanced chronic kidney disease and was eventually diagnosed with primary lymphoma. He responded well to intensive chemotherapy and recovered renal function, although he was left with some functional limitations as a consequence of his treatment regimen. Our report highlights the importance of keeping neoplastic conditions under consideration when taking care of children with severe kidney disease of unclear etiology.
Diagnostic Clue in a Neonate with Amniotic Band Sequence
Authors: Raffaele Falsaperla, Marta Arrabito, Piero Pavone, Valentina Giacchi, Tiziana Timpanaro, Paolo Adamoli
Journal: Case Rep Pediatr (2020)
MeSH terms: Case Reports

Amniotic band syndrome (ABS) is a set of congenital malformations that mainly affect the limbs and more rarely the skull, face, chest, and abdomen. Two main hypotheses have been proposed to explain the nature of the disorder: an intrinsic and extrinsic factor. We report a newborn with ABS presenting with several malformations involving both hands and foot. In this case, the malformative event localized at the hands and right foot without involvement of any other internal organs and is asymmetric which leads us to suppose the extrinsic factor as cause of the ABS.
Randomized Controlled Trial of the Picture Book Reading Program on Cognitive Function in Middle-Aged People
Authors: Ai Iizuka, Hiroyuki Suzuki, Susumu Ogawa, Tomoya Takahashi, Daisuke Cho, Daichi Yamashiro, Kenichiro Sato, Yan Li, Yuri Kanabe, Momoko Kobayashi, Yoshinori Fujiwara
Journal: Front Psychiatry (2021)
Keywords: cognitive function, cognitive intervention, middle-aged people, picture book reading, randomized controlled trial, verbal fluency
MeSH terms: Case Reports

Background: To delay cognitive decline, it is important to engage actively in preventive activities from middle age (50-64 years of age). We have developed a cognitive intervention program using picture book reading, and demonstrated that it is effective for improving memory in older adults. However, the effect of the intervention on memory and other cognitive functions in middle-aged people has not been examined. The current study investigated the effects of the picture book reading program on cognitive function in middle-aged people. Methods: This single-blind (examiners were blinded) randomized controlled trial was conducted in Tokyo, Japan. A total of 65 participants were randomly assigned to the intervention group (IG) (n = 32), in which members attended 12 picture book reading classes held once a week, or the active control group (CG) (n = 33), in which members received lectures on health maintenance. Cognitive tests were conducted before and after the intervention. The primary outcome was memory, and the secondary outcomes were verbal function and executive function. Results: The results showed that there was no significant difference between the IG and the CG in change scores (post minus pre) for memory. On the other hand, there was a significant difference in change scores of the category fluency, which is a measure of verbal function, suggesting improvements in IG compared to CG. There were also no significant differences in executive function. Conclusions: The results indicated that our previous finding of an improvement in memory function in older adults was not found in middle-aged people. However, the findings suggest that the picture book reading program may affect lexical access ability in verbal function among middle-aged people. Because maintaining verbal function is important for daily communication, these findings suggest that this program may be a useful countermeasure for cognitive decline in middle-aged people. Clinical Trial Registration: University Hospital Medical Information Network Clinical Trial Registry, https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000048012, Identifier: UMIN 000042071.
Novel suicide by division of a chronically infected, externalised axillofemoral graft presenting challenges in prehospital assessment of mental capacity
Authors: Lewis G Stevens, Keith J Roberts
Journal: Case Rep Emerg Med (2012)
MeSH terms: Case Reports

Assessing a patient's competence to give informed consent in pre-hospital care is difficult. In the presented case an elderly patient attempted suicide by division of a chronically infected and externalised prosthetic arterial graft. He was able to comprehend his situation and understand the consequences of declining treatment. Without prior knowledge of his medical care and psychological state, however, we did not believe we could fully assess the patient's ability to act in his own best interest. After sedation and resuscitation he was transferred to hospital. This case report discusses a unique method of suicide and the challenge of obtaining valid consent in prehospital care.
Effects of elexacaftor/tezacaftor/ivacaftor therapy on mental health of patients with cystic fibrosis
Authors: Linus Piehler, Ralf Thalemann, Christine Lehmann, Stephanie Thee, Jobst Röhmel, Zulfiya Syunyaeva, Mirjam Stahl, Marcus A Mall, Simon Y Graeber
Journal: Front Pharmacol (2023)
Keywords: anxiety, cystic fibrosis, depression, elexacaftor/tezacaftor/ivacaftor, mental health

Introduction: The CFTR modulator drug elexacaftor/tezacaftor/ivacaftor (ETI) was shown to improve CFTR function and clinical symptoms in patients with cystic fibrosis (CF) with at least one F508del allele. Recently, some case reports suggested potential side effects of ETI on mental health with an increase in depressive symptoms and even suicide attempts in patients with CF. However, the general effects of this triple combination therapy on the mental health status of patients with CF remain largely unknown. Methods: We, therefore, performed a prospective, observational study in a real-life setting and investigated the relationship between initiation of ETI therapy and changes in mental health in adult patients with CF. We assessed Cystic Fibrosis Questionnaire-Revised (CFQ-R), Patient Health Questionnaire-9 (PHQ-9), Beck's Depression Inventory - Fast Screen (BDI-FS) and Generalized Anxiety Disorder 7-item Scale (GAD-7) at baseline and 8-16 weeks after initiation of ETI. Results: In total, 70 adult patients with CF with at least one F508del allele and a median age of 27.9 years were recruited. After initiation of ETI, the CFQ-R respiratory domain score improved by 27.9 (IQR 5.6 to 47.2; p < 0.001). The PHQ-9 score of depressive symptoms decreased by 1.0 (IQR -3.0 to 0.3; p < 0.05) with an increase of 16.9% in the group with a minimal score after initiation of ETI and a decrease in the groups of mild (-11.3%) or moderate (-5.7%) scores compared to baseline. The BDI-FS score of depressive symptoms decreased from 1.0 (IQR 0.0-2.0) at baseline to 0.0 (IQR 0.0 to 2.0; p < 0.05) after initiation of ETI. The group with a minimal BDI-FS score increased by 8.0% after initiation of ETI, whereas the groups with mild (-4.9%), moderate (-1.6%) or severe (-1.6%) scores decreased compared to baseline. The GAD-7 score of anxiety symptoms did not change after initiation of ETI compared to baseline (0.0; IQR -2.0. to 0.0; p = 0.112). Conclusion: Initiation of ETI improves symptoms of depression in adult patients with CF with at least one F508del allele. However, symptoms of anxiety do not change after short-term therapy with ETI.
Ertapenem-Induced Encephalopathy in a Patient With Normal Renal Function
Authors: S Scott Sutton, Mark Jumper, Sean Cook, Babatunde Edun, Michael D Wyatt
Journal: J Investig Med High Impact Case Rep (2017)
Keywords: drug-induced encephalopathy, drug-induced neurotoxicity, ertapenem

Drug-induced neurotoxicity is a rare adverse reaction associated with ertapenem. Encephalopathy is a type of neurotoxicity that is defined as a diffuse disease of the brain that alters brain function or structure. We report a patient with normal renal function who developed ertapenem-induced encephalopathy manifesting as altered mental status, hallucinations, and dystonic symptoms. The patient's symptoms improved dramatically following ertapenem discontinuation, consistent with case reports describing ertapenem neurotoxicity in renal dysfunction. Since clinical evidence strongly suggested ertapenem causality, we utilized the Naranjo Scale to estimate the probability of an adverse drug reaction to ertapenem. Our patient received a Naranjo Scale score of 7, suggesting a probable adverse drug reaction, with a reasonable temporal sequence to support our conclusion.
Myroides cellulitis and bacteremia: A case report
Authors: William A Beathard, Aaron Pickering, Micah Jacobs
Journal: IDCases (2021)
Keywords: antibiotic resistance, bacteremia, cellulitis, myroides
MeSH terms: Case Reports

Formerly classified under the genus Flavobacterium, Myroides species are common gram-negative, environmental bacterium ubiquitous in soil and water. While infrequent, infections of human hosts can result in devastating consequences due the bacteria's intrinsic multidrug resistance, particularly in those who are immunocompromised. The pathogenicity and mechanisms for resistance remain poorly understood at this time. The case presented in this report details Myroides bacteremia secondary to a soft tissue infection of the lower extremities and adds to the 60 documented infections to date, of which 15 were also characterized by a similar infection.
Are They Just Two Children COVID-19 Cases Confused With Flu?
Authors: Biao Zou, Di Ma, Yinhu Li, Liru Qiu, Yu Chen, Yan Hao, Xiaoping Luo, Sainan Shu
Journal: Front Pediatr (2020)
Keywords: covid-19, children, influenza, nucleic acid, serum antibody of sars-cov-2
MeSH terms: Case Reports

COVID-19, an emerging infectious disease, has quickly spread all over the world. All human populations are susceptible to this disease. Here we present two pediatric COVID-19 cases, both of whom exhibited negative SARS-CoV-2 nucleic acid tests upon nasopharyngeal swab and were initially diagnosed with influenza A infection. COVID-19 was later confirmed in both patients by serum antibodies of SARS-CoV-2 and nucleic acid test on stool samples. Because children are susceptible to many respiratory pathogens, especially influenza, we concluded that children can be coinfected with multiple pathogens, and more attention should be paid to the exploration of SARS-CoV-2 during the pandemic of COVID-19. This report shows the possibility of misdiagnosis or missed diagnosis of children with COVID-19. We suggest that highly suspected pediatric COVID-19 cases with negative nucleic acid tests on nasopharyngeal swabs should be further checked by performing a nucleic acid test on stool samples and testing serum for antibodies against SARS-CoV-2.
Unilateral Vulvar Pneumatocele (Pneumolabium) Diagnosed during Robotic Hysterectomy
Authors: Dani Zoorob, Mahala Spalsbury, Tiffany Slutz, Madeleine Oliver, Ibrahim Tsolakian, Jeffrey Judis
Journal: Case Rep Obstet Gynecol (2019)
MeSH terms: Case Reports

Background:
Persistent canal of Nuck may manifest in adulthood and be detected after increased abdominal pressure.
Case:
A 52-year -old female undergoing a robotic hysterectomy developed an acute left labial enlargement. The patient was discovered to have an 8 × 4 × 4 cm swelling in the left labium majus. Palpation revealed the mass to be air-filled and reducible by gentle compression with slow redevelopment upon release of the pressure while intra-abdominal insufflation was maintained.
Conclusion:
We present the first case of a labial pneumatocele during robotic hysterectomy. We theorize that the underlying cause to be a patent canal of Nuck that, once supplied with increasing abdominal peritoneal pressure, allowed air to travel into the labia majora through the inguinal canal. Simple reduction corrected the pneumatocele and no complications or recurrence was noted postop. This case suggests that pathologies of the canal of Nuck should be considered in the differential of an adult presenting with inguinal or genital swelling.
A Practical Approach to the Percutaneous Treatment of Iatrogenic Aorto-coronary Dissection
Authors: George Kassimis, Tushar Raina
Journal: Open Cardiovasc Med J (2018)
Keywords: acute coronary syndromes, aortic dissection, cardiac catheterization, guiding catheter, iatrogenic, percutaneous coronary intervention
MeSH terms: Case Reports

Catheter-induced aortic dissection during coronary angiography and Percutaneous Coronary Intervention (PCI) is a relatively infrequent, but potentially life-threatening complication. Patients who suffer this complication may require emergency aortic surgery. More recently, reports of treating the ostium of the dissected coronary artery have emerged as an alternative therapeutic option. In this article we describe two cases of extensive guide catheter induced dissection and their successful treatment using PCI and provide a concise overview of the available literature.