OpenMed/multicare-articles huggingface dataset:
Trabectedin-Related Heart Failure: Case Report and a Systematic Review of the Literature
Authors: Julien Catherine, Christiane Jungels, Valerie Durieux, Coralie Deliens, Bogdan Grigoriu
Journal: Front Oncol (2021)
Keywords: acute, cardiac, cardiac biomarkers, drug-induced, toxicity, trabectedin
MeSH terms: Review

New drugs come not only with benefits but also with unexpected toxicities which need to be promptly recognized and managed. Starting from a scholar case of acute heart failure with preserved ejection fraction following the administration of trabectedin (ET-743, Yondelis®) in a patient with a metastatic solitary fibrous tumor, we performed a systematic review of the literature encompassing the results of previous cardiac safety analysis published ten years ago, a review of clinical trials published during the last 10 years as well as single-case descriptions related to trabectedin cardiotoxicity. The estimated incidence of cardiac toxicity was 3,4% among patients receiving trabectedin, with recent data suggesting a higher rate of heart failure than previously recognized. Previous or concomitant anthracyclines exposure may represent a risk factor. Assaying for NT-pro-BNP may be useful for the early detection of individuals with trabectedin-induced heart failure.
Horizontal Ridge Augmentation Using a Xenograft Bone Substitute for Implant-Supported Fixed Rehabilitation: A Case Report with Four Years of Follow-Up
Authors: Bruno Freitas Mello, Márcio de Carvalho Formiga, Luiz Fernando de Souza da Silva, Gustavo Dos Santos Coura, Jamil Awad Shibli
Journal: Case Rep Dent (2020)
MeSH terms: Case Reports

The guided bone regeneration (GBR) technique has been used to achieve optimal bone volume augmentation and allow dental implant placement in atrophic maxilla and mandible, with predictable results and high survival rates. The use of bone substitutes has reduced the necessity of autogenous bone grafts, reducing the morbidity at the donor areas and thus improving the patients' satisfaction and comfort. This clinical case report shows a clinical and histological evaluation of the bone tissue behavior, in a case that required the horizontal augmentation of the alveolar ridge, with the use of xenograft biomaterial and further dental implant placement. After six months of healing time, six implants were placed, and a bone biopsy was done. The histological analysis depicted some fragments of the xenograft bone graft, integrated with the new-formed bone tissue.
Shoshin beriberi induced by long-term administration of diuretics: a case report
Authors: Naoki Misumida, Hisashi Umeda, Mitsunori Iwase
Journal: Case Rep Cardiol (2014)

Previous studies have suggested that diuretic therapy for heart failure may lead to thiamine deficiency due to the increased urinary thiamine excretion. Herein, we present the case of a 61-year-old man with shoshin beriberi, a fulminant form of wet beriberi, induced by long-term diuretic therapy. The patient had a history of heart failure with preserved ejection fraction and was receiving furosemide and trichlormethiazide therapy. He presented with worsening exertional dyspnea and was admitted for heart failure exacerbation. His condition failed to improve even after intensive treatment. A hemodynamic evaluation with the Swan-Ganz catheter revealed high-output heart failure with low peripheral vascular resistance. Thiamine was administered for suspected shoshin beriberi; his hemodynamic status improved dramatically within the next six hours. The serum thiamine level was below the normal range; the patient was therefore diagnosed with shoshin beriberi. The common causes of thiamine deficiency were not identified. Long-term diuretic therapy with furosemide and thiazide was thought to have played a major role in the development of thiamine deficiency. This case illustrates the importance of considering wet beriberi as a possible cause of heart failure exacerbation in patients taking diuretics, even when the common thiamine deficiency causes are not identified with history-taking.
Skin diseases of the nipple and areola complex: A case series study from China
Authors: Chao Wu, Qian-Nan Jia, Kai Fang, Yue-Ping Zeng
Journal: Front Med (Lausanne) (2023)
Keywords: adenoma of the nipple, breast, eczema, nipple and areola complex, skin diseases

Background:
Skin diseases of the nipple and areola complex (NAC) are numerous and difficult to diagnose, which is a great challenge for clinicians. A better understanding of the clinical features of NAC skin diseases is of great value for the correct diagnosis.
Methods:
To investigate the clinical characteristics of skin diseases of the NAC, we retrospectively analyzed the demographic data, disease constitution, rash characteristics, inconsistency between the clinical and pathological diagnosis from 260 patients with NAC lesions that were confirmed by histopathology at Peking Union Medical College Hospital, China from 2012 to 2022.
Results:
The patients' average age was 43.6 (8 to 82) years, and the ratio of females to males was 13.4:1. Out of the 260 patients biopsied, the most common diseases were eczema, Paget's disease (PD), adenoma of the nipple (AN), seborrheic keratosis (SK), cutaneous metastasis of breast cancer, wart, soft fibroma, and hyperkeratosis of the nipple and areola. There were 77 (29.6%) patients with inconsistency between the clinical impressions and pathological diagnoses. AN was the most clinically misdiagnosed condition, most commonly presumed to be PD or eczema.
Conclusion:
Eczema and PD are the most common biopsied NAC skin diseases. Late onset, unilateral involvement, and predilection for the nipple are several characteristics of PD, which are different from eczema. NAC skin diseases are easily misdiagnosed clinically, especially AN.
Moyamoya Syndrome (MMS) in a Patient With Sickle Cell Disease (SCD) and Protein S Deficiency
Authors: Parima Saxena, Hussam Alkaissi, Riddhi Chauhan, John Muthu
Journal: Cureus (2023)
Keywords: endovascular surgery, hereditary protein s deficiency, moyamoya disease (mmd), secondary stroke prevention, sickle cell disease
MeSH terms: Case Reports

The association between Moyamoya syndrome (MMS) and sickle cell disease (SCD) has been well-established in pediatric populations; however, limited literature exists documenting the characteristics and management of MMS in adult SCD patients. Studies have indicated the role of endovascular management in secondary stroke prevention for pediatric populations, with no current guidelines available for adult populations. Here, we describe a unique case of MMS in a 30-year-old patient with SCD and incidental protein S deficiency. Our unique case highlights a patient at high risk for neurosurgical intervention due to her hypercoagulable state who has benefitted from medical management. We also discuss current literature for the prevention of secondary cerebral vascular events and the role of further studies involving adult populations with MMS and SCD.
Successful Vaginal Delivery after External Cephalic Version in a Woman with a Large Partial Uterine Septum
Authors: Kristen E Park, Nicole L Vestal, Michael S Awadalla, Sharon A Winer
Journal: Case Rep Obstet Gynecol (2021)
MeSH terms: Case Reports

Septate uteri have been associated with adverse pregnancy outcomes including spontaneous abortion, preterm delivery, and malpresentation. It is unclear if uterine septa are associated with infertility. Although some studies have shown improved pregnancy outcomes after septum resection, indications for resection are not well established. We describe a case of a woman with a large partial uterine septum diagnosed during workup for infertility who conceived without septum resection. Both of her subsequent pregnancies were initially breech presentations for which the patient underwent external cephalic version followed by full-term vaginal deliveries. This case adds evidence that an unresected uterine septum should not be considered a contraindication to external cephalic version.
Primary Amoebic Meningoencephalitis in an Infant due to Naegleria fowleri
Authors: Vinay Khanna, Ruchee Khanna, Shrikiran Hebbar, V Shashidhar, Sunil Mundkar, Frenil Munim, Karthick Annamalai, Deepak Nayak, Chiranjay Mukhopadhayay
Journal: Case Rep Neurol Med (2011)
MeSH terms: Case Reports

Primary amoebic meningoencephalitis (PAM) caused by free-living amebae Naegleria fowleri is a rare and fatal condition. A fatal case of primary amoebic meningoencephalitis was diagnosed in a 5-month-old infant who presented with the history of decrease breast feeding, fever, vomiting, and abnormal body movements. Trophozoites of Naegleria fowleri were detected in the direct microscopic examination of CSF and infant was put on amphotericin B and ceftazidime. Patient condition deteriorated, and he was discharged against medical advice and subsequently expired. We also reviewed previously reported 8 Indian cases of primary amoebic meningoencephalitis (PAM) and observed that for the last 5 years, none of the patients responded to amphotericin B. Has an era of amphotericin B-resistant Naegleria fowleri been emerged? Management strategy of PAM needs to be reviewed further.
Case Report: Chlamydia psittaci pneumonia complicated by Guillain-Barré syndrome detected using metagenomic next-generation sequencing
Authors: Changquan Fang, Limin Xu, Jiarong Tan, Hongyi Tan, Junhong Lin, Ziwen Zhao
Journal: Front Cell Infect Microbiol (2023)
Keywords: guillain-barre syndrome, antibiotic therapy, chlamydia psittaci pneumonia, metagenomic next-generation sequencing, psittacosis
MeSH terms: Chlamydophila psittaci / genetics, Guillain-Barre Syndrome / complications, Guillain-Barre Syndrome / diagnosis, Pneumonia / complications, Psittacosis / complications, Psittacosis / diagnosis, Case Reports, Research Support, Non-U.S. Gov't, Anti-Bacterial Agents / therapeutic use, Fatigue / complications, High-Throughput Nucleotide Sequencing, Humans, Anti-Bacterial Agents

Psittacosis and Guillain-Barré syndrome are both rare clinical diseases with low incidence, and their combination has rarely been reported. Here, we report a case of Chlamydia psittaci pneumonia combined with Guillain-Barré syndrome. The patient initially presented with high fever, difficulty breathing, and fatigue. Chest computerised tomography indicated large consolidation opacities in both lungs. Metagenomic next-generation sequencing clearly identified the pathogen as C. psittaci. The patient's fever subsided after targeted antibiotic treatment, but difficulty breathing and fatigue worsened, and the patient developed symmetric limb numbness and weakness. Lumbar puncture, electrophysiological examination, and clinical characteristics were suggestive of Guillain-Barré syndrome, and the symptoms improved after treatment with human immunoglobulin. The results of this study suggest that metagenomic next-generation sequencing is useful for the rapid diagnosis of pulmonary infectious agents. Psittacosis is closely associated with the development of Guillain-Barré syndrome; however, more cases are needed to support this conclusion, and early targeted antibiotic treatment, immunotherapy, and basic supportive treatment are essential for improving outcomes.
Case Report: Report of Two Cases of Interstitial Lung Disease Caused by Novel Compound Heterozygous Variants in the ABCA3 Gene
Authors: Fang Chen, Zhiwei Xie, Victor Wei Zhang, Chen Chen, Huifeng Fan, Dongwei Zhang, Wenhui Jiang, Chunli Wang, Peiqiong Wu
Journal: Front Genet (2022)
Keywords: abca3, ild, interstitial lung disease, pediatric, surfactant protein dysfunction
MeSH terms: Case Reports

Interstitial lung disease (ILD) is a heterogeneous group of pulmonary disorders involving the lung interstitium and distal airways, also known as diffuse lung disease. The genetic defects resulting in alveolar surfactant protein dysfunction are a rare cause of ILD in pediatric patients. We report two unrelated pediatric patients with shortness of breath, dyspnea and hypoxemia, and the chest CT findings including patchy ground-glass opacity in both lung fields, suggestive of diffuse ILD. One patient was a full-term male infant who had shortness of breath a few hours after the birth, and then developed into severe respiratory distress syndrome (RDS). Whole exome sequencing revealed novel compound heterozygous variants in the ABCA3 gene (NM_001,089.3): paternally inherited c.4035+5G > A and c.668T > C (p.M223T), and maternally inherited c.1285+4A > C. The second patient was a 34-month-old boy with onset of chronic repeated cough and hypoxemia at 9 months of age. We unveiled novel compound heterozygous ABCA3 variants (c.704T > C, p.F235S; c.4037_4040del, p.T1346Nfs*15) in this patient. Surfactant protein dysfunction due to bi-allelic mutations in the ABCA3 gene was the cause of ILD in two patients. The novel mutations found in this study expanded the spectrum of known mutations in the ABCA3 gene.
Simultaneous Bilateral Insufficiency Femoral Fractures After Long-Term Alendronate Treatment: A Lesson Not Yet Learned
Authors: Dimitrios Rigkos, Ioannis Savvidis, Alexia Bisbinas, Georgios Markopoulos, Ilias Bisbinas
Journal: Cureus (2023)
Keywords: alendronate, atypical fractures, bilateral, bisphosphonates, insufficiency femoral fractures, simultaneous
MeSH terms: Case Reports

Bisphosphonates have recently been used as a first-line treatment for osteoporosis. However, prolonged bisphosphonate use may be associated with insufficiency and atypical femoral fractures. In this case report, we present a patient with simultaneous bilateral insufficiency femoral fractures after using alendronate for 11 years, which were treated surgically. Our patient also had a history of a previous right femoral atypical fracture eight years before the latest ones, while on 3-year alendronate treatment. To our knowledge, it is the first patient reported with three atypical - insufficiency fractures covering all the anatomical areas of the proximal half of the femur after long-term bisphosphonate treatment.
Intraneural ganglion cyst involving the tibial nerve-a case report
Authors: Christina E Buckley, Emma Tong, Liam D Spence, Michael O'Shaughnessy
Journal: BJR Case Rep (2017)
MeSH terms: Case Reports

Intraneural ganglia are rare non-neoplastic cysts that are caused by an accumulation of thick mucinous fluid. This occurs within the epineurium of peripheral nerves, which is encased in a dense fibrous capsule. The most common presentation of this tumour is local and/or radiating pain. Involvement of the tibial nerve is extremely uncommon, with less than 18 reported cases in the literature. We present a case of an intraneural tibial nerve ganglion cyst in a young male. We also discuss the current literature and proposed pathogenesis and treatment of this rare entity.
Entrapped Catheter across the Fossa Ovalis in an Adult with Pulmonary Stenosis - A Case Report of Surgical Relief
Authors: Vithalkumar Malleshi Betigeri, Girish Gopinathan, Indira Malik, Manoj Kumar Sanwal, Vishnu Datt, Deepak Kumar Satsangi
Journal: Int Cardiovasc Res J (2014)
Keywords: cardiac valve annuloplasty, complications, echocardiography, pulmonary valve stenosis, valvular heart disease congenital
MeSH terms: Case Reports

Percutaneous pulmonary balloon valvuloplasty as a procedure of choice in adults has been established since the last three decades. Even though the complications are rare, they are scarcely reported in the literature. We report such a case in an adult female patient of severe pulmonary valular stenosis in whom, entrapped catheter across the fossa ovalis was noted in chest x-ray and echocardiogram following unsuccessful percutaneous pulmonary balloon valvuloplasty. Our case emphasizes this rare complication and its successful surgical outcome.
Atypical presentation of forearm compartment syndrome in a case of vascular type Ehlers-Danlos syndrome
Authors: Tsang Yeung, Ching San Esther Chow
Journal: Case Reports Plast Surg Hand Surg (2023)
Keywords: compartment syndrome, ehlers–danlos syndrome, hong kong chinese, pseudoaneurysm, saphenous vein graft
MeSH terms: Case Reports

A 30-year-old Chinese man with vascular type Ehlers-Danlos Syndrome presents with spontaneous right forearm compartment syndrome due to pseudoaneurysms along the radial artery. Emergency fasciotomy and reconstruction of the radial artery with a saphenous vein graft were performed. Genetic test showed a heterozygous DNA change c. 1852 G > C in COL3A1 gene.
Nilotinib-Induced Immune-Mediated Liver Injury: Corticosteroid as a Possible Therapeutic Option
Authors: Hyun Yang, Pil Soo Sung, Eun Sun Jung, Sungwoo Cho, Si Hyun Bae, Dong-Wook Kim
Journal: Front Oncol (2020)
Keywords: chronic myeloid leukemia, corticosteroid, drug induced liver injury, hepatotoxicity, nilotinib
MeSH terms: Case Reports

Introduction: Nilotinib is a BCR-ABL tyrosine kinase inhibitor approved for chronic myeloid leukemia. We present a case of severe immune-mediated liver injury by nilotinib treatment. Case report: A 59-year-old woman was referred to the liver clinic because of elevated liver enzyme levels. One year prior, she was diagnosed as having chronic myeloid leukemia and treated with nilotinib therapy. The level of aspartate aminotransferase and alanine aminotransferase were 578 IU/L and 499 IU/L, respectively. Percutaneous needle liver biopsy showed extensive centrilobular infiltration of immune cells and destruction of the lobular architecture with minimal inflammation in the portal triad. Immunohistochemical staining showed that many CD8+ T cells and CD56+ cells infiltrated the site of inflammation. Multicolor fluorescence-activated cell-sorting analysis revealed that a considerable number of intrahepatic CD8+ T cells showed an activated phenotype compared with the healthy control. She was diagnosed with nilotinib-induced, immune-mediated liver injury. Prednisolone treatment (30 mg daily) was started and caused rapid normalization of liver enzyme levels. Conclusion: Nilotinib can cause immune-mediated liver injury. The use of corticosteroid can be treatment option in immune-mediated liver injury.
A Rare Manifestation of Tuberculosis Presenting in the United States
Authors: Osman Bhatty, David Waters, Nicholas Wilka, Shradha Samuel, John Horne, Renuga Vivekanandan
Journal: Case Rep Infect Dis (2016)
MeSH terms: Case Reports

A 64-year-old Bangladeshi female presented to her primary care physician with a tender right breast lump that had been present for 4-5 days along with subjective fevers and malaise. Initial biopsy revealed granulomas, but Ziehl-Neelsen and Gram stain were negative for TB so antibiotics were prescribed for abscess until culture came positive for tuberculosis. She was started on triple therapy for extrapulmonary tuberculosis, an exceedingly rare presentation that requires high clinical suspicion in the Western world.
Challenges of cardiac sarcoidosis
Authors: Irina R Strambu
Journal: Front Med (Lausanne) (2023)
Keywords: cardiac mri, cardiac sarcoidosis, corticosteroids, guidelines, sarcoidosis
MeSH terms: Review

Sarcoidosis is a multisystem granulomatosis of unknown origin, which can involve almost any organ. Most frequently the disease involves the lungs and mediastinal lymph nodes, but it can affect the skin, the eyes, nervous system, the heart, kidneys, joints, muscles, calcium metabolism, and probably any other anecdotical organ involvement. Cardiac sarcoidosis is one of the most challenging involvements, as it can lead to cardiac mortality and morbidity, and also because the diagnosis may be difficult. With no specific symptoms, cardiac sarcoidosis may be difficult to suspect in a patient with no previous extra-cardiac sarcoidosis diagnosis. This manuscript reviews the current knowledge of the diagnosis and decision to treat cardiac sarcoidosis, and illustrates the information with a case presentation of a young adult with no risk factors, no previous diagnosis of sarcoidosis, and with cardiac symptoms impairing his quality of life.
Hematocrit Sign Elucidates Cause of Abdominal Pain
Authors: Jeffrey Lam, Steven Montague
Journal: POCUS J (2021)
Keywords: pocus, hematocrit sign, kidney disease
MeSH terms: Case Reports

A 78-year-old male with chronic kidney disease on peritoneal dialysis developed unprovoked bilateral pulmonary embolisms. He was started on IV unfractionated heparin, but shortly thereafter developed severe pain and a small firm abdominal nodule near his dialysis catheter site. The diagnosis was unknown, and the initial plan was watchful waiting, until point-of-care ultrasound (POCUS) was used. POCUS revealed an ovoid mass with hyperdensity in the gravity dependent regions with spontaneous movement. This appearance was classic for the hematocrit sign. When combined with the clinical presentation, this was concerning for a rectus sheath hematoma. An urgent CT of the abdomen confirmed this several hours later. POCUS allowed for rapid bedside diagnosis, which expedited appropriate care in a potentially life-threatening situation.
Case Report: Perioperative Kounis Syndrome in an Adolescent With Congenital Glaucoma
Authors: Guglielmo Capponi, Mattia Giovannini, Ioanna Koniari, Francesca Mori, Chiara Rubino, Gaia Spaziani, Giovanni Battista Calabri, Silvia Favilli, Elio Novembre, Giuseppe Indolfi, Luciano De Simone, Sandra Trapani
Journal: Front Cardiovasc Med (2021)
Keywords: kounis syndrome, coronary artery, midazolam, pediatrics, perioperative, sevoflurane
MeSH terms: Case Reports

A 12-year-old male patient suffering from congenital glaucoma developed bradycardia, left ventricular failure, and hypotension after induction of anesthesia. Electrocardiography and echocardiography revealed a complete normalization of ECG and a complete spontaneous recovery in the cardiac function 72 hours from the beginning of the clinical manifestations, while cardiac Magnetic Resonance Imaging was performed, and coronary Computed Tomography scan revealed a myocardial bridge of a tract of the left anterior descendent coronary artery. Diagnosis of Kounis syndrome (KS) was made, a relatively novel, under-recognized clinical condition, defined as the manifestation of an acute coronary syndrome accompanied by mast cell activation and platelet aggregation involving interrelated and interacting inflammatory cells in the setting of allergic, hypersensitivity, anaphylactic or anaphylactoid insults. We described one of the first pediatric cases of KS related to anesthetic medications. In children, this syndrome has been only described in isolated case reports or small case series. Thus, it appears critical to report new cases of KS in children to increase the awareness of this disease in pediatric healthcare workers so as to enhance its early recognition and optimal therapeutic strategy. Furthermore, it appears of paramount importance the implementation of universal guidelines accepted by allergology and cardiology societies, in order to standardize the management of pediatric and adult patients with KS. Finally, a close collaboration between pediatric allergists and cardiologists seems fundamental for an optimal multidisciplinary patient care.