OpenMed/multicare-articles huggingface dataset:
Herpes Simplex Virus Colitis in a Patient with Newly Diagnosed Crohn's Disease
Authors: H Jafri, D R Kalina, T Aziz, P E Serrano, S Haider
Journal: Case Rep Med (2018)
MeSH terms: Case Reports

Herpesvirus colitis is a known cause of morbidity and mortality amongst immunosuppressed individuals. We present a case of HSV colitis following a diagnosis of Crohn's Disease and methylprednisolone therapy. Diagnosis was confirmed by immunohistochemical staining and supported by polymerase chain reaction (PCR) of cutaneous vesicles. The patient recovered following three weeks of acyclovir.
A Case of Diffuse Alveolar Hemorrhage Associated with High-Titer of MPO-ANCA Demonstrating Cytoplasmic Staining Pattern
Authors: Jihad Ben Gabr, Hiroshi Kato
Journal: Case Rep Rheumatol (2019)
MeSH terms: Case Reports

Diffuse alveolar hemorrhage (DAH) is a life-threatening complication of ANCA-associated vasculitis (AAV) that requires urgent recognition and treatment. A presumptive diagnosis is often rendered without histopathology if concordant positivity of ANCA by indirect immunofluorescence (IIF) and ELISA assays, i.e., P-ANCA+/myeloperoxidase (MPO) Ab+ or C-ANCA+/proteinase-3 (PR3) Ab+, is documented in the context of pulmonary-renal syndrome or rapidly progressive glomerulonephritis. In this respect, the discordance between IIF and ELISA assays poses a diagnostic challenge in the absence of convincing histopathology and involves the risks of delaying the implementation of timely immunosuppressive therapy. Here, we report a 74-year-old woman who developed DAH and was found to have a high titer of MPO-ANCA exhibiting cytoplasmic staining on IIF, i.e., MPO-C-ANCA. The literature suggests that the availability of distinct epitopes on the MPO molecule dictates the perinuclear versus cytoplasmic staining pattern, which potentially explains the discordance between ELISA and IIF assays. Her DAH was controlled in association with seven sessions of plasmapheresis, methylprednisolone 1 gram daily for 3 days followed by 1 mg/kg/day, and rituximab. This case exemplifies the importance of consideration of pretest probability of suspected diagnosis that would realize a plausible interpretation of seemingly inconsistent serological profile and its effective incorporation into the diagnostic reasoning.
Serial pathologic fractures of five long bones on four separate occasions in a patient with primary hyperparathyroidism, challenges of management in a developing country: a case report
Authors: Samuel Adegboyega Olatoke, Olayide Sulaiman Agodirin, Ganiyu Adebisi Rahman, Olufemi Gbenga Habeeb, Rabiu Olusegun Jimoh, Bola Abdulkadir Ahmed, Sikiru Biliaminu, Olanrewaju Olubukola Oyedepo
Journal: Pan Afr Med J (2013)
Keywords: pathologic fractures, primary hyperparathyroidism, parathyroid adenoma, serum calcium, surgery
MeSH terms: Adenoma / complications, Fractures, Bone / etiology, Hyperparathyroidism, Primary / etiology, Parathyroid Neoplasms / complications, Case Reports, Adenoma / pathology, Adenoma / surgery, Adult, Developing Countries, Humans, Hyperparathyroidism, Primary / diagnosis, Male, Nigeria, Parathyroid Neoplasms / pathology, Parathyroid Neoplasms / surgery, Parathyroidectomy / methods, Recurrence

Multiple pathologic fractures secondary to parathyroid adenoma is rarely recognized and reported in the tropics. Inadequate evaluation causes worsened disability and increased psychological stress. We present a 27-year-old Nigerian male student with recurrent unexplained pathological fractures of the long bones. Primary Hyperparathyroidism was later diagnosed and he benefited from a unilateral parathyroidectomy. Primary hyperparathyroidism secondary to parathyroid adenoma is difficult to diagnose and needs a high index of suspicion. Surgery and good post-operative biochemical control of serum calcium produce satisfying outcomes.
Daptomycin-Induced Posterior Reversible Encephalopathy Syndrome (PRES)
Authors: A Bitar De Zayas-Enriquez, C Soper
Journal: Case Rep Neurol Med (2019)
MeSH terms: Case Reports

Aims:
To present a 60-year-old female patient who manifested clinical and radiological features of posterior reversible encephalopathy syndrome (PRES) following the administration of Daptomycin for glycopeptide-resistant Enterococcal urinary tract infection.
Material:
Case report.
Method:
Posterior reversible encephalopathy syndrome was diagnosed in our patient following the administration of Daptomycin based on clinical suspicion as well as brain CT and MRI imaging.
Results:
The temporal association between the initiation of Daptomycin and the onset of PRES is highly suggestive of causality, and this is further supported by clinical and radiological resolution after Daptomycin was withdrawn.
Conclusion:
This is the first report of Daptomycin-induced posterior reversible encephalopathy syndrome.
Endovascular treatment of chronic mesenteric ischemia in an adolescent male: case report
Authors: Sadiq Muhammed Al-Hammash, Abd El-Salam Dawood Al-Ethawi, Kasim Abbas Ismail
Journal: F1000Res (2013)

Chronic mesenteric ischemia (CMI) is a condition characterized by inadequate blood flow to the bowel resulting from stenosis of one or more of the three mesenteric arteries. Fibromuscular dysplasia is the most common cause in children and young adults; whereas atherosclerosis is the most common cause in the elderly. Treatment is mandatory in symptomatic patients, because it may lead to malnutrition, bowel infarction or even death.Herein, we present the case of a 14-year old male, diagnosed with CMI who underwent percutaneous balloon angioplasty (PTA) followed by stent placement with immediate positive results.
Managing Toe Walking, a Treatment Side Effect, in a Child With T-Cell Non-Hodgkin's Lymphoma: A Case Report
Authors: Wojciech Kiebzak, Arkadiusz Żurawski, Anna Zmyślna, Justyna Pogorzelska, Małgorzata Domagalska-Szopa, Magdalena Hagner-Derengowska, Andrzej Szopa
Journal: Front Pediatr (2019)
Keywords: diers formetric 4d, childhood cancer, gait disorders, physiotherapy, toe walking
MeSH terms: Case Reports

Background and Purpose: Children who have survived cancer are at risk of experiencing adverse effects of the cancer or its treatments. One of the adverse effects may be the limitation of ankle dorsiflexion (DF), which may result in "toe walking." Although there is an increasing number of studies in pediatric oncology presenting evidences of different therapeutic interventions to improve DF function, none of these therapeutic interventions has been sufficiently documented. This case report shows the results of non-invasive neurodevelopmental treatment program combined with application of inhibiting casts in a pediatric cancer patient who presented with severe and persistent toe walking. The treatment was aimed to improve DF function and postural and gait pattern and to normalize weight distribution between forefoot and heel. Case Presentation: A 7-year-old girl with T-cell lymphoma, who presented with severe and persistent toe walking, was assessed 10 times over a course of 6 months by both clinical examination (ankle range of motion measurement) and neurophysiological measures (weight distribution between forefoot and hindfoot, postural sway, body posture, and gait). Outcomes: Neurodevelopmental treatment program combined with application of inhibiting casts for 3 months increased passive ankle DF by 10° in both lower limbs, normalized weight distribution between the forefoot and heel in both lower limbs, as well as established a heel-toe walking gait pattern. Improved ankle DF function and normalized postural and gait patterns were maintained in repeated examinations even 3 months after the removal inhibiting casts. Discussion: Early identification of toe walking in the female pediatric patient with T-cell non-Hodgkin's lymphoma and early physiotherapy intervention were beneficial in terms of her body posture and gait pattern development. Non-invasive neurodevelopmental treatment program combined with application of inhibiting casts as described in this study can be useful for managing treatment side effects in pediatric cancer patients.
A Case Report of Pulmonary Exacerbation after Initiation of Lumacaftor/Ivacaftor Therapy in a CF Female with Complicated Lung Disease
Authors: Elpis Hatziagorou, Eleana Kouroukli, Vasiliki Georgopoulou, John Tsanakas
Journal: Case Rep Pulmonol (2018)
MeSH terms: Case Reports

Novel targeted treatments for Cystic Fibrosis give rise to new hope for an ever-growing number of CF patients with various mutations. However, very little evidence and guidelines exist to steer clinical decisions regarding patients whose illness takes an unexpected course. In such cases, the benefits and risks of discontinuing these treatments must be carefully and individually weighed, since their long-term effects remain mainly uncharted territory. In this report we document the case of a homozygous F508del CF patient with severe lung disease who presented with a pulmonary exacerbation shortly after the beginning of treatment with lumacaftor/ivacaftor and the complicated initial phase of therapy, which was followed by significant improvements.
The nectarine pit as a cause for small bowel obstruction and perforation: a case report
Authors: Mahmoud Al-Najjar, Thomas Arthur
Journal: Case Rep Surg (2013)

Ingestion of a foreign body is a rare cause of small bowel obstruction. Ingested foreign bodies will usually pass without clinical sequelae, however on occasion can contribute to significant morbidity. Here we present an unusual case of small bowel obstruction and perforation as a result of accidental ingestion of a nectarine pit.
Cerebral Venous Sinus Thrombosis in a Patient with Ulcerative Colitis Flare
Authors: L M Conners, R Ahad, P H Janda, Z Mudasir
Journal: Case Rep Neurol Med (2018)
MeSH terms: Case Reports

Inflammatory bowel disease is characterized by a chronic inflammatory state and is therefore associated with abnormalities in coagulation and a hypercoagulable state. Cerebral venous sinus thrombosis is a rare complication of inflammatory bowel disease yet contributes significant morbidity and mortality to those affected. Early diagnosis is critical, as a delay in diagnosis portends a worse prognosis. This paper seeks to highlight the increased risk of venous sinus thrombosis in patients with inflammatory bowel disease. We start by discussing the case of a seventeen-year-old female who presented with ulcerative colitis flare and developed new-onset seizures, found to be caused by a large venous sinus thrombosis.
Metastasis of dermatofibrosarcoma from the abdominal wall to the thyroid gland: case report
Authors: Alexander Kreze Jr, Andrea Zápotocká, Tomáš Urbanec, Jiří Koskuba, Mikuláš Pura, Pavel Vítek, Pavol Praženica, Eva Traboulsi
Journal: Case Rep Med (2012)

Metastases in the thyroid gland are very rare. Even the rarer are sarcoma metastases. A 52-year-old woman was referred to our department for evaluation of a nodule in the right lobe of the thyroid gland. She had a history dermatosarcoma of the abdominal wall with known metastasis in the lung. Clinically she had neck pain and worsened swallowing. Objective assessment (ultrasound, computed tomography, and magnetic resonance) indicated a voluminous right lobe nodule with mechanical syndrome, and a fine-needle aspiration biopsy revealed a very suspicious malignant finding. After surgery, the diagnosis was metastasis of dermatofibrosarcoma protuberans. Subsequent treatment was radio- and chemotherapy.
Para testicular rhabdomyosarcoma in adults: three case reports and review of literature
Authors: Lamiae Boudahna, Zineb Benbrahim, Lamiae Amaadour, Aicha Mazouz, Khadija Benhayoune, Yassir Tahiri, Moulay Hassan Farih, Afaf Amarti, Samia Arifi, Nawfel Mellas
Journal: Pan Afr Med J (2014)
Keywords: para testicular rhabdomyosarcoma, adults, tumor
MeSH terms: Antineoplastic Combined Chemotherapy Protocols / therapeutic use, Rhabdomyosarcoma / pathology, Testicular Neoplasms / pathology, Case Reports, Review, Adolescent, Adult, Humans, Male, Orchiectomy / methods, Practice Guidelines as Topic, Rhabdomyosarcoma / diagnosis, Rhabdomyosarcoma / therapy, Testicular Neoplasms / diagnosis, Testicular Neoplasms / therapy, Treatment Outcome, Young Adult

Paratesticular embryonal rhabdomyosarcoma (RMS) is a rare tumor arising from the mesenchymal tissues of the spermatic cord, epididymis, testis and testicular tunics. We report three cases of adult paratesticular RMS, two embryonic and one pleomorphic rhabdomyosarcoma. All the patients underwent diagnostic orchidectomy. The work up investigations revealed lung metastases. Chemotherapy with Ifosfamide and Doxorubicin was used in two cases, whereas Vincristin-Actinomycin D and Cyclophosphamide was received in one case. An objective partial response was reported in 2 cases, with complete response in one case. Paratesticular RMS is a rare and aggressive tumor. Because of the absence of protocols designed specifically for adult patients, it is necessary to follow therapeutic guidelines in pediatric protocols.
Kikuchi-fujimoto disease in a 30-year-old caucasian female
Authors: David J Archibald, Matthew L Carlson, Ray O Gustafson
Journal: Int J Otolaryngol (2009)
MeSH terms: Case Reports

Kikuchi-Fujimoto disease is a rare, self-limited, histiocytic, necrotizing lymphadenitis first described in Japan in 1972. Necrosis of lymph node tissue is caused by apoptosis and may be virally induced. It commonly presents with cervical lymphadenitis and fever. Despite its low incidence, Kikuchi-Fujimoto disease should be considered in patients with persistent lymphadenopathy. Originally thought to occur only in young Asian women, it is now recognized in other geographic regions. We report a 30-year-old white woman with Kikuchi-Fujimoto disease. We discuss the clinical features, differential diagnosis, radiography, pathology, and outcome.
Neurotrophic Keratopathy after Trigeminal Nerve Block for Treatment of Postherpetic Neuralgia
Authors: Aya Kodama-Takahashi, Koji Sugioka, Tomoko Sato, Koichi Nishida, Keiichi Aomatsu, Masahiko Fukuda, Yoshikazu Shimomura
Journal: Case Rep Ophthalmol Med (2018)
MeSH terms: Case Reports

Purpose:
To report a case of persistent corneal epithelial defect that had occurred after a trigeminal nerve block.
Case presentation:
A 75-year-old female had suffered from postherpetic neuralgia for 8 years. She underwent Gasserian ganglion block surgery and noticed declining visual acuity in the right eye on the following day. She presented with severe hyperemia and corneal epithelial defects in the right eye and experienced remarkable reduction of sensitivity in the right cornea. She was diagnosed with neurotrophic keratopathy. Ofloxacin eye ointment and rebamipide ophthalmic suspension ameliorated the corneal epithelial defects but superficial punctate keratopathy, corneal superficial neovascularization, and Descemet's fold persisted. Although the epithelial defects occasionally recurred, the corneal sensation and epithelial defects, Descemet's fold, and corneal superficial neovascularization all improved around 5 months after trigeminal nerve block. The HRT II Rostock Cornea Module (RCM) could not detect any corneal subbasal nerve fibers at postoperative 4 months; however, it could detect them at postoperative 6 months.
Conclusions:
As the nerve block effect wore off, the corneal subbasal nerve fibers slowly regenerated. As the corneal sensation improved, the corneal epithelial defects and superficial neovascularization also improved. The HRT II RCM appeared useful for observing loss and regeneration of the corneal subbasal nerve fibers.
Radium-223 as an Additional Therapeutic Strategy in Highly Selected Patients With Metastatic Breast Cancer: A Case Report
Authors: Hélène Houssiau, Francois P Duhoux, Didier François, Emmanuel Seront
Journal: Front Oncol (2022)
Keywords: bone metastases, breast cancer, chemotherapy, positron emitted tomography, radium-223
MeSH terms: Case Reports

Radium-223 is commonly used in metastatic prostate cancer, targeting specifically bone metastases. The use of radium-223 remains, however, poorly evaluated in metastatic breast cancer. We report a case of radium-223 treatment in a 59-year-old patient with bone-only metastatic disease that progressed on multiple lines of systemic treatments. Radium-223 was very well tolerated and resulted in a regression of activity of bone metastases and in a 6-month progression-free survival. However, progression occurred in the liver, reflecting the fact that radium-223 should be combined with other systemic agents. This suggests that this therapeutic option is feasible and could be proposed in highly selected patients with bone metastatic disease outside of the prostate cancer field. Positron Emission Tomography appears also as a valuable tool for the evaluation of radium-223 efficacy.
High Lyso-Gb3 Plasma Levels Associated with Decreased miR-29 and miR-200 Urinary Excretion in Young Non-Albuminuric Male Patient with Classic Fabry Disease
Authors: Sebastián Jaurretche, Germán R Perez, Graciela Venera
Journal: Case Rep Nephrol (2019)
MeSH terms: Case Reports

Renal involvement is associated with a greater morbidity and mortality in Fabry disease. Pathological albuminuria, the first Fabry nephropathy clinical manifestation, can occur from early childhood, although histological lesions such as tubulo-interstitial fibrosis and glomerulosclerosis are present or may precede the onset of pathological albuminuria. In renal cells, exposure to Lyso-Gb3 is correlated with increased expression of Transforming Growth Factor-βeta (TGF-β). miR-21, miR-192, and miR-433 that promote fibrosis are activated by TGF-β, and miR-29 and miR-200 that suppress fibrosis are inhibited by TGF-β. A 23-year-old male was diagnosed with FD. αGalA decreased enzyme activity: 0.1 nmol/hour/liter; genotype: [c.317T>G (p.L106R)]; GFR: 104.4 mL/min/m2; urinary albumin excretion: 6.00 mg/day; plasma Lyso-Gb3: 124.5 nmol/L. A decrease urinary excretion of miR-29 and miR-200 was found (p <0.005) compared to controls. In addition to its usefulness as a phenotype marker, Lyso-Gb3 has been proposed as an indicator of therapeutic response. We detect an association of high Lyso-Gb3 plasma values with decreased urinary excretion of miRNAs with known antifibrotic effect (miR-29 and miR-200). Although the present work is a case report, it could be hypothesized that one of the harmful Lyso-Gb3 effects could be the miRNAs regulation through changes in TGF-β expression.
A Rare Case of Ruptured Tailgut Cyst Leading to Carcinomatosis
Authors: Samir Atiya, Adam Horn, Whitney Wedel, Nicholas Lintel
Journal: Case Rep Pathol (2023)
MeSH terms: Case Reports

Tailgut cysts are congenital cysts arising in the retrorectal space. They are thought to be benign with variable malignancy risks. We report a case with previous surgical intervention decades prior that had undergone a tailgut cyst excision with surgical complications leading to carcinomatosis. An elderly female (70s) presented with tailbone/pelvic pain. She underwent cyst excision that was complicated by an intraoperative rupture. The cyst was pathologically proven to be a tailgut cyst with adenocarcinoma. She presented 13 months postoperatively to the emergency department with worsening abdominal pain. Imaging was concerning for diffuse omental nodules and narrowing of the proximal sigmoid colon. She was not deemed to be a surgical candidate and was transitioned to hospice care, where she passed away shortly afterward. This case report highlights the utility of complete excision of tailgut cysts and possible complications.
Treatment for complete bilateral duplex kidneys with severe hydronephrosis and ureterectasis of the upper moiety in a child: A case report and literature review
Authors: Chengchuang Wu, Fengming Ji, Huangchenghao Zhang, Zhigang Yao, Li Li, Bing Yan
Journal: Front Surg (2022)
Keywords: child, duplex kidney, renal malformation, ureterostomy, ureteroureterostomy
MeSH terms: Case Reports

Aim:
To explore the treatment experience of the duplex kidney.
Method:
A case of the complete bilateral duplex kidney with severe hydronephrosis and ureterectasis in the upper moiety of the kidney diagnosed in the Department of Urology of Kunming Children's Hospital from 2021 to 2022 was retrospectively analyzed and relevant literature was reviewed.
Results:
A 2-month-old baby girl was admitted to the hospital because of hydronephrosis of bilateral kidneys found by prenatal ultrasound for 3 months and fever for 3 days. After being given the relevant examinations, the girl was diagnosed with complete bilateral duplex kidneys with severe hydronephrosis and ureterectasis in the upper moiety, and urinary tract infection. The patient's urinary tract infection was poorly controlled after positive anti-infective therapy, so a bilateral ureterostomy was performed. After the surgery, urinary tract infection was soon cured. A bilateral ureteroureterostomy was performed 13 months later, and the patient recovered after 7 days.
Conclusion:
Cutaneous ureterostomy combined with late ureteroureterostomy for children with complete bilateral duplex kidneys with severe hydronephrosis in the upper moiety and ureter are not only beneficial to caregivers' nursing after the operation, but also have significance for salvaging renal function.
A Report of a Large Axillary Cystic Hygroma (a.k.a Lymphangioma) in a Newborn from a Tertiary Hospital in Northern Tanzania
Authors: Jay Lodhia, Rune Philemon, Patrick Amsi, Kondo Chilonga, David Msuya
Journal: Case Rep Surg (2020)
MeSH terms: Case Reports

Introduction:
Cystic hygroma is a rare condition of the lymphatic system that occurs mainly in children. They are found around the neck, axilla, inguinal, or thoracic regions. Case Presentation. A newborn female baby with a right-sided axillary mass since birth was admitted to our center. She was otherwise a healthy baby with noncontributory prenatal history. The mass was 12 cm in diameter and cystic. Wide excision of the mass was done, and histology confirmed cystic hygroma. Postoperatively, the baby did well clinically and was discharged.
Conclusion:
Due to its rare incidence, reports and literature on management of cystic hygroma are few. A multidisciplinary approach is vital to yield the best prognosis for this rare condition.
Non operative management of traumatic esophageal perforation leading to esophagocutaneous fistula in pediatric age group: review and case report
Authors: Biplab Mishra, Saurabh Singhal, Divya Aggarwal, Nitesh Kumar, Subodh Kumar
Journal: World J Emerg Surg (2015)
Keywords: conservative, esophageal perforation, iatrogenic, non-operative, pediatric, perforation, protocol, thoracic, traumatic

Management of delayed presenting esophageal perforations has long been a topic of debate. Most authors consider definitive surgery being the management of choice. Management, however, differs in pediatric patients in consideration with better healing of younger tissues. We extensively review the role of aggressive non-operative management in pediatric esophageal perforations, especially with delayed presentation and exemplify with case of a young boy with esophageal perforation and esophago-cutaneous fistula. We also lay down the protocol to manage such patients based on our institutional recommendations.