OpenMed/multicare-articles huggingface dataset:
Congenital circumferential constriction band of the abdomen: a case report
Authors: Kapil Gargh, Carol Sullivan, Hamish Laing, Sujoy Banerjee
Journal: Case Rep Med (2009)
MeSH terms: Case Reports

We report a case of congenital constriction band of abdomen associated with limb pseudarthrosis. The constriction band around the abdomen, though may cause initial difficulty with ventilation and parental distress, does not interfere with feeding, bowel movements, and growth. It heals spontaneously with supportive treatment though surgery may be needed in some cases.
Justified Suspicion: Symptomatic Syphilitic Alopecia in a Patient with Well-Controlled HIV
Authors: Robert Jame, Yousif Al-Saeigh, Leo L Wang, Kevin Wang
Journal: Case Rep Infect Dis (2021)
MeSH terms: Case Reports

Background:
An estimated 25% of primary and secondary syphilis, a sexually transmitted infection caused by the spirochete bacterium Treponema pallidum, occurs in patients coinfected with human immunodeficiency virus (HIV) (Chesson et al., 2005). This association is especially evident in men who have sex with men (MSM). In HIV-positive patients, primary syphilis infection may progress more rapidly to the tertiary, and most destructive, stage and reinfection can start with the latent or tertiary stage; in such patients, advanced syphilis may arise without clinical warning signs (Kenyan et al., 2018). It is important to note that neurosyphilis can occur during any stage of infection in all patients, regardless of immunocompetence status (CDC, 2021). Case Presentation. A 56-year-old male with a past medical history of well-controlled HIV with a CD4 count of 700 cells/mm3 and an undetectable viral load, psoriasis, and a remote episode of treated syphilis, presented with a two-week history of a diffuse desquamating rash, alopecia, sinusitis, unilateral conjunctivitis, and blurred vision. His last sexual encounter was over ten months ago. The diagnosis of syphilis was confirmed by microhemagglutination assay, and he was treated for presumed neuro-ocular infection with a two-week course of intravenous Penicillin G.
Conclusion:
Syphilis has acquired a reputation as "the great masquerader" due to its protean manifestations. It may follow an unpredictable course, especially in HIV-positive patients, including those whose treatment has achieved undetectable serology. For example, ocular syphilis may present in an otherwise asymptomatic individual (Rein, 2020) and alopecia may arise as the sole indication of acute syphilitic infection (Doche et al., 2017). Therefore, a high index of suspicion is warranted in order to prevent severe and irreversible complications.
Metastatic Extramammary Paget's Disease of Scrotum Responds Completely to Single Agent Trastuzumab in a Hemodialysis Patient: Case Report, Molecular Profiling and Brief Review of the Literature
Authors: Peter Barth, Essel Dulaimi Al-Saleem, Kristin W Edwards, Sherri Z Millis, Yu-Ning Wong, Daniel M Geynisman
Journal: Case Rep Oncol Med (2015)

Extramammary Paget's disease (EMPD) is a rare cancer. Although EMPD is usually noninvasive and treated with local therapy, once metastatic the prognosis of EMPD is poor and treatment options are limited. We report a case of a complete response to single agent trastuzumab in a hemodialysis patient with metastatic Her2/neu overexpressed EMPD of the scrotum. Molecular profiling of his case as well as 12 other EMPD and 8 mammary Paget disease (MPD) cases was completed and revealed multiple biomarker aberrations. Overexpression of Her2 was frequently noted (30%-40%) in both EMPD and MPD patients and when present can be effectively treated with Her2 targeted agents. Trastuzumab therapy can be safely utilized in a hemodialysis patient. In addition, multiple protein overexpression and loss were seen in EMPD including PD-1, PD-L1, PTEN, and AR as well as PIK3CA mutation. These findings may lead to possible therapeutic interventions targeting these pathways in a disease with few effective treatment options.
Sudden cardiac death in anabolic androgenic steroids abuse: case report and literature review
Authors: Ana Isabel Hernández-Guerra, Javier Tapia, Luis Manuel Menéndez-Quintanal, Joaquín S Lucena
Journal: Forensic Sci Res (2019)
Keywords: forensic sciences, anabolic androgenic steroids (aas), autopsy, cardiac pathology, forensic pathology, sudden cardiac death, toxicology
MeSH terms: Case Reports

Anabolic androgenic steroids (AAS) have several adverse effects on the cardiovascular system that may lead to a sudden cardiac death (SCD). We herein report a case involving a 24-year-old male, AAS abuser with intramuscular delivery in the 6 months before, who suffered a cardiorespiratory arrest at home's bathtub when returning from New Year's party. A forensic autopsy was performed according to the guidelines of the Association for European Cardiovascular Pathology (AECVP). The body showed hypertrophy of skeletal musculature, with low amount of subcutaneous fat and no signs of injury (body mass index, BMI: 26.8 kg/m2). On internal examination, there were multiorgan congestion, acute pulmonary edema, and cardiomegaly (420 g) with severe coronary atherosclerosis and superimposed acute occlusive thrombosis at the left main trunk and left anterior descendant. Areas of scarring were located at the intersection between the posterior wall and the posterior third of the septum (postero-septal). At histology, acute myocardial infarction at the anterior third of the septum and the anterior wall, and subacute myocardial infarction at apical septum and apical posterior wall were detected. Other findings were small intramyocardial vessel disease and myocytes hypertrophy. Chemicotoxicological analysis in blood showed ethanol ((0.90 ± 0.05) g/L), stanazolol (11.31 µg/L), nandrolone (2.05 µg/L) and testosterone (<1.00 µg/L). When confronted with a sudden death in a young athlete we must pay attention to the physical phenotype that may suggest AAS abuse and perform a detailed examination of the heart. Chemicotoxicological analysis is a key to establish the relationship between SCD and AAS abuse.
Secondary Erythrocytosis Associated with Uterine Myoma Is Rare but Should Be of Concern
Authors: Ekasak Thiangphak, Ingporn Jiamset, Phawat Matemanosak, Athithan Rattanaburi
Journal: Case Rep Obstet Gynecol (2023)
MeSH terms: Case Reports

Myomatous erythrocytosis syndrome (MES) is a rare gynecological condition, defined by the presence of the clinical triad of erythrocytosis, uterine fibroids, and normalization of red blood cell counts after the surgical removal of uterine fibroids. Herein, we report the case of a woman, in the postmenopausal stage, with the clinical triad of MES. She had a history of erythrocytosis of unknown etiology and underwent phlebotomy for a year prior to visiting our hospital. Pre-operative hemoglobin (Hb) level, hematocrit (Hct) level, and red blood cell (RBC) count were 18.1 g/dL, 56.1%, and 6.52 million cells/μL, respectively. She underwent exploratory laparotomy, transabdominal hysterectomy, and bilateral salpingo-oophorectomy. The operative findings revealed a large uterine myoma, and the pathology result was compatible with uterine leiomyoma. All hematologic parameters returned to the normal range on post-operative day 1. Her hematologic parameters returned to normal values 4 weeks after surgery with a Hb level of 13.5 g/dL, Hct level of 41.2%, and RBC count of 4.92 million cells/μL. The exact pathophysiology of this condition remains unknown. However, surgical removal of uterine myoma is the mainstay of treatment. Despite the rarity of this condition, its diagnosis should be considered in patients presenting with erythrocytosis and uterine masses.
Case report: Successful management of Parvimonas micra pneumonia mimicking hematogenous Staphylococcus aureus pneumonia
Authors: Yanmei Feng, Chunxia Wu, Xiaohui Huang, Xia Huang, Li Peng, Rui Guo
Journal: Front Med (Lausanne) (2022)
Keywords: p micra pneumonia, dysbiosis, new etiology, oral flora, poor oral hygiene
MeSH terms: Case Reports

Parvimonas micra is an anaerobic Gram-positive coccus frequently found in the oral cavity and gastrointestinal tract, but rarely in the lung. Therefore, pneumonia caused by P. micra is also rare. Although there are some reports of P. micra related pneumonia due to aspiration or blood-borne infection with definite remote infection source, there are no reported cases of hematogenous P. micra pneumonia in healthy adults lacking a remote source of infection. Herein, we described the intact disease of P. micra-related pneumonia mimicking hematogenous Staphylococcus aureus pneumonia in terms of chest imagery and diagnosed via metagenomic next-generation sequencing (mNGS). Interestingly, there was no clear remote pathogenic source identified in the patient. Microbiome analysis revealed dysbiosis of the oral flora possibly related to poor oral hygiene and a long history of smoking. The patient was treated with moxifloxacin for 3 months. Ultimately, computed tomography (CT) of the chest showed total resolution of the lung lesion. Clinicians need to update the etiology of community-acquired pneumonia. When antibiotic therapy is not effective, pathogen examination becomes very important. New methods of pathogen detection such as mNGS should be employed to this end. For the treatment of P. micra pneumonia, no standardized course of treatment was reported. Imaging absorption of lung infections may provide a more objective guidance for the duration of antibiotics in P. micra pneumonia.
Bilateral sleeve fracture of the inferior poles of the patella in a healthy child: case report and review of the literature
Authors: Stephen Paul Guy, Jan Luigi Marciniak, Nirmal Tulwa, Andrew Cohen
Journal: Adv Orthop (2011)
MeSH terms: Case Reports

The initial diagnosis of a sleeve fracture of the patella is key to a successful outcome with poor results well documented in the literature from delayed management. Diagnosis is difficult due to the rarity of this injury and thus the low likelihood the admitting junior doctor would think of this injury in their differential. They are very uncommon in incidence and have features on plain radiography that are difficult to interpret unless the surgeon is familiar with the anatomy of the immature patella. Missing the diagnosis can be disastrous for the patient. In this paper we describe the presentation of bilateral sleeve fractures in a healthy child, our initial investigations and subsequent management. We chose to repair with 5 Ethibond via 3 transosseous tunnels, initially reinforced with a circlage wire. On last review the boy maintains stable, pain-free knees with a full range of motion. The authors hope that this case and literature review will provide a valuable teaching aid and so assist in early, accurate diagnosis and cover the management options to achieve a positive outcome.
Case report: Spindle cell neoplasm presenting as a spontaneous intestinal perforation in a term infant
Authors: Lauren T Callaghan, Anthea Lafreniere, Ekene A Onwuka, Ross M Beckman, Jennifer H Foster, Norma Quintanilla, Charleta Guillory, Timothy C Lee, Lily S Cheng
Journal: Front Pediatr (2022)
Keywords: braf, infantile fibrosarcoma, neonatal neoplasm, spindle cell neoplasm, spontaneous intestinal perforation
MeSH terms: Case Reports

Spontaneous intestinal perforations in the neonatal population are mostly associated with low birth weight, prematurity, and necrotizing enterocolitis. Spontaneous intestinal perforation in the absence of these risk factors is extremely rare and should raise clinical concern for an underlying bowel pathology. Here we present a unique case of a normal-weight, full-term girl with spontaneous intestinal perforation due to a spindle cell neoplasm with a novel BRAF mutation and infantile fibrosarcoma-like morphology. Though rare, malignancy should be considered in the differential diagnosis for bowel perforation in an otherwise healthy, term infant as complete surgical excision can be curative.
Light chain cast nephropathy caused by plasmablastic lymphoma of the bladder
Authors: Mehrian Jafarizade, Kiran Goli, Vivette D'Agati, Essel Dulaimi, Krupa Daniel, Bradley Lash, Sharon Maynard
Journal: Clin Nephrol Case Stud (2021)
Keywords: hiv, acute kidney injury, bladder lymphoma, interstitial nephritis, light chain cast nephropathy, lymphoma, plasmablastic lymphoma
MeSH terms: Case Reports

Introduction:
Plasmablastic lymphoma (PBL) is a rare form of B-cell lymphoma typically seen in patients with underlying immunosuppression such as HIV, autoimmune disease, and organ transplantation. PBL in HIV-positive patients usually originates from the gastrointestinal tract, with a predilection for the oral cavity. Bladder involvement by PBL is exceedingly rare, and cast nephropathy due to κ light chain-secreting PBL has not been reported previously.
Case report:
We report a patient who presented with acute kidney injury (AKI) in the setting of HIV, and was found to have a bladder tumor. Bladder pathology revealed a high-grade PBL with κ light chain restriction. Renal biopsy showed κ light chain cast nephropathy, presumably secondary to κ light chain-secreting PBL.
Conclusion:
Although the prognosis of PBL is poor, our patient recovered from AKI, achieved complete hematologic remission with chemotherapy, and underwent successful autologous stem cell transplant.
Inquilinus limosus in patients with cystic fibrosis, Germany
Authors: Nele Wellinghausen, Andreas Essig, Olaf Sommerburg
Journal: Emerg Infect Dis (2005)
MeSH terms: Alphaproteobacteria / isolation & purification, Cystic Fibrosis / microbiology, Case Reports, Adolescent, Alphaproteobacteria / drug effects, Anti-Bacterial Agents / pharmacology, Female, Germany, Humans, Male, Microbial Sensitivity Tests, Anti-Bacterial Agents

We identified Inquilinus limosus, a recently described ?-proteobacterium, in sputum of 2 patients with cystic fibrosis whose respiratory tracts were persistently colonized for >9 months. We present data on the epidemiology, antimicrobial susceptibility, and molecular characteristics of I. limosus.
Potential and limitations of digital ethnographic research: A case study on a web community
Authors: Giuseppe Masullo, Marianna Coppola
Journal: Front Sociol (2023)
Keywords: case study, digital ethnographic research, qualitative research, shortfalls and advantages, typology of asexual people

Introduction:
This work aims at transposing ethnographic research into digital contexts to probe its potential and limitations in a specific field of study: that of sexuality, particularly suited to ethnographic exploration. We chose as our case study a web community of Italian asexual people. As we shall see, this allowed us to simultaneously explore both the various techniques called into play in digital ethnography and the digital as a specific sphere within which sexuality takes on a very peculiar meaning. Digital sociality is paramount for the definition of imaginaries, meanings, and practices that could not be explored elsewhere. This is due to the implicit characteristics of the population studied, which does not find corresponding physical spaces of aggregation.
Methods:
The paper will present the research design using this specific case study to address some of the typical dilemmas that researchers face when following the digital ethnographic approach and will explore the research results as an example of the kind of analysis available with the information and data collected through this method.
Results and discussion:
The conclusions will attempt to briefly outline the shortfalls and advantages of this method, considering its application to this specific field of study.
Icatibant for Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema in Intubated Patients: Case Series and Literature Review
Authors: Erin K Yeung, Haritha Saikumar, Jose Castaneda-Nerio, Sandra G Adams, Mark Wong
Journal: Case Rep Crit Care (2018)
MeSH terms: Case Reports

Purpose:
A case series of icatibant use in intubated patients with angiotensin-converting enzyme inhibitor- (ACEI-) induced angioedema is presented along with a relevant literature review and recommendations for utilization.
Summary:
Three intubated patients admitted to the intensive care unit for ACEI-induced angioedema were treated with icatibant. A literature search identified one controlled study and four case reports describing the use of icatibant in intubated ACEI-induced angioedema patients.
Conclusion:
Icatibant administration in intubated patients may be beneficial in decreasing time to extubation and length of intensive care unit stay. In the three cases described, icatibant administration did not appear to elicit a response in intubated patients, which has been described in previous case reports. For clinicians considering icatibant in the treatment of ACEI-induced angioedema, earlier administration upon arrival to the ED or immediately upon arriving to the intensive care unit is strongly advised. The suggested benefit of icatibant in intubated ACEI-induced angioedema patients should be verified by randomized clinical trials and cost-benefit analyses should be performed at individual institutions.
Localization of the epileptogenic foci in tuberous sclerosis complex: a pediatric case report
Authors: Alexander Hunold, Jens Haueisen, Banu Ahtam, Chiran Doshi, Chellamani Harini, Susana Camposano, Simon K Warfield, Patricia Ellen Grant, Yoshio Okada, Christos Papadelis
Journal: Front Hum Neurosci (2014)
Keywords: electroencephalography, epileptogenic zone, equivalent current dipole, magnetoencephalography, pediatric epilepsy, tuberous sclerosis complex

Tuberous sclerosis complex (TSC) is a rare disorder of tissue growth and differentiation, characterized by benign hamartomas in the brain and other organs. Up to 90% of TSC patients develop epilepsy and 50% become medically intractable requiring resective surgery. The surgical outcome of TSC patients depends on the accurate identification of the epileptogenic zone consisting of tubers and the surrounding epileptogenic tissue. There is conflicting evidence whether the epileptogenic zone is in the tuber itself or in abnormally developed surrounding cortex. Here, we report the localization of the epileptiform activity among the many cortical tubers in a 4-year-old patient with TSC-related refractory epilepsy undergoing magnetoencephalography (MEG), electroencephalography (EEG), and diffusion tensor imaging (DTI). For MEG, we used a prototype system that offers higher spatial resolution and sensitivity compared to the conventional adult systems. The generators of interictal activity were localized using both EEG and MEG with equivalent current dipole (ECD) and minimum norm estimation (MNE) methods according to the current clinical standards. For DTI, we calculated four diffusion scalar parameters for the fibers passing through four ROIs defined: (i) at a large cortical tuber identified at the right quadrant, (ii) at the normal appearing tissue contralateral to the tuber, (iii) at the cluster formed by ECDs fitted at the peak of interictal spikes, and (iv) at the normal appearing tissue contralateral to the cluster. ECDs were consistently clustered at the vicinity of the large calcified cortical tuber. MNE and ECDs indicated epileptiform activity in the same areas. DTI analysis showed differences between the scalar values of the tracks passing through the tuber and the ECD cluster. In this illustrative case, we provide evidence from different neuroimaging modalities, which support the view that epileptiform activity may derive from abnormally developed tissue surrounding the tuber rather than the tuber itself.
Identification of a novel HER3 activating mutation homologous to EGFR-L858R in lung cancer
Authors: Ijeoma Umelo, Amir Noeparast, Gang Chen, Marleen Renard, Caroline Geers, Johan Vansteenkiste, Philippe Giron, Olivier De Wever, Erik Teugels, Jacques De Grève
Journal: Oncotarget (2016)
Keywords: her inhibitor, her3 kinase mutation, her3-v855a, lung cancer
MeSH terms: Antineoplastic Agents / therapeutic use, Carcinoma, Non-Small-Cell Lung / drug therapy, Carcinoma, Non-Small-Cell Lung / genetics, Erlotinib Hydrochloride / therapeutic use, Lung Neoplasms / drug therapy, Lung Neoplasms / genetics, Protein Kinase Inhibitors / therapeutic use, Receptor, ErbB-3 / genetics, Case Reports, Clinical Trial, Phase II, Multicenter Study, Research Support, Non-U.S. Gov't, Adolescent, Amino Acid Sequence, Brain Neoplasms / secondary, Carcinoma, Non-Small-Cell Lung / secondary, Cell Line, Tumor, Crystallography, X-Ray, ErbB Receptors / genetics, Genetic Predisposition to Disease, Humans, Lung Neoplasms / pathology, Male, Molecular Sequence Data, Mutation / genetics, Neuregulin-1 / metabolism, Phosphorylation, Prospective Studies, Protein Structure, Tertiary, Receptor, ErbB-2 / metabolism, Receptor, ErbB-3 / metabolism, Tomography, X-Ray Computed, Antineoplastic Agents, Neuregulin-1, Protein Kinase Inhibitors, neuregulin beta, Erlotinib Hydrochloride, EGFR protein, human, ERBB2 protein, human, ERBB3 protein, human, ErbB Receptors, Receptor, ErbB-2, Receptor, ErbB-3

Somatic mutations found within the tyrosine kinase domain (TKD) of the human epidermal growth factor (HER) family of receptors have been implicated in the development and progression of non-small cell lung cancer (NSCLC). However, no conclusive reports have described pathogenic mutations in kinase-impaired HER3. Here, we report a case of an advanced chemotherapy-resistant NSCLC, harboring a novel HER3(V855A) somatic mutation homologous to the EGFR(L858R)activating mutation. Co-expression of HER3(V855A) and wild-type HER2 enhances ligand-induced transformation of murine and human cell lines, while HER-targeted inhibitors potently suppress mutant HER3 activity. Consistent with these observations, in silico computational modeling predicts that mutant V855A alters the kinase domain and c-terminal end of the HER3 protein. Taken together, these findings provide a basis for the clinical exploration of targeted therapies in HER3 mutant NSCLC and by extrapolation, in other cancers that more frequently carry somatic HER3 mutations.
Transient oligoarthritis of the lower extremity following influenza B virus infection: Case report
Authors: Normi Bruck, Manfred Gahr, Frank Pessler
Journal: Pediatr Rheumatol Online J (2010)

A 12-year-old girl developed influenza B virus infection proven by typical symptoms and detection of the virus in a nasopharyngeal swab by culture and PCR. Two weeks later she developed an otherwise unexplained transient oligoarthritis of small joints of the left foot. Influenza viruses may be a hitherto underappreciated cause of a post-infectious arthritis.
Adenovirus-like inclusion body hepatitis in a flock of broiler chickens in Kermanshah province, Iran
Authors: Morad Rahimi, Zahra Minoosh Siavosh Haghighi
Journal: Vet Res Forum (2015)
Keywords: adenovirus, broiler, hepatitis, inclusion body, iran
MeSH terms: Case Reports

Inclusion body hepatitis (IBH) has been reported in many countries in the world. The IBH or similar cases characterized by hepatitis and presence of intra-nuclear inclusion bodies in hepatocytes have not been reported in broiler chickens in Iran. This is the first report on outbreak of adenovirus-like inclusion body hepatitis in Iran. On October 2012, an onset of high acute mortality in a flock of 2 day-old broiler chickens was reported to the Veterinary Clinic, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran. The birds showed lethargy, huddling, ruffled feathers, and inappetence. At necropsy the livers were the primary organ affected which were enlarged, pale yellow with necrotic foci and multiple petechial hemorrhages. Tissue samples of liver, kidneys and heart were fixed in 10% buffered formalin. They were processed and stained with hematoxylin and eosin for histopathological studies. Significant microscopic lesions were seen in the livers. Large eosinophilic intra-nuclear inclusion bodies were seen in hepatocytes. Based on the acute high mortality, age of the broilers, gross lesions and histopathological findings (especially intra-nuclear inclusion bodies), the condition was diagnosed as adenovirus-like inclusion body hepatitis.