OpenMed/multicare-articles huggingface dataset:
Preeclampsia-Associated Multivessel Spontaneous Coronary Artery Dissection
Authors: Rajeev Virender Seecheran, Jessica Kawall, Divya Ramadhin, Valmiki Krishna Seecheran, Sangeeta Anjali Persad, Sasha Savitri Lalla, Naveen Anand Seecheran
Journal: J Investig Med High Impact Case Rep (2019)
Keywords: pascad, scad, st-segment elevation myocardial infarction, stemi, multivessel dissection, preeclampsia, pregnancy-associated spontaneous coronary artery dissection, spontaneous coronary artery dissection
MeSH terms: Coronary Vessel Anomalies / etiology, Pre-Eclampsia / diagnosis, Vascular Diseases / congenital, Case Reports, Adult, Cineangiography, Coronary Vessel Anomalies / diagnosis, Coronary Vessel Anomalies / diagnostic imaging, Electrocardiography, Female, Humans, Male, Pre-Eclampsia / pathology, Pregnancy, ST Elevation Myocardial Infarction / complications, ST Elevation Myocardial Infarction / diagnosis, Vascular Diseases / diagnosis, Vascular Diseases / diagnostic imaging, Vascular Diseases / etiology, Coronary Artery Dissection, Spontaneous

Pregnancy-associated spontaneous coronary artery dissection (PASCAD) accounts for less than 5% of spontaneous coronary artery dissection cases and is comparatively more fulminant or clinically aggressive. Several factors associated with PASCAD include black ethnicity, multiparity, hypertension, advanced maternal age, and age at first childbirth. This atypical case highlights a preeclamptic patient presenting with an ST-segment elevation myocardial infarction in which multivessel dissection of both the left anterior descending and right coronary arteries were deemed co-culprit lesions for the index event.
Prediction of Potential Associations Between miRNAs and Diseases Based on Matrix Decomposition
Authors: Pengcheng Sun, Shuyan Yang, Ye Cao, Rongjie Cheng, Shiyu Han
Journal: Front Genet (2020)
Keywords: computational prediction model, endometrial cancer, matrix decomposition (mfmda), mirna, mirna–disease association

It is known that miRNA plays an increasingly important role in many physiological processes. Disease-related miRNAs could be potential biomarkers for clinical diagnosis, prognosis, and treatment. Therefore, accurately inferring potential miRNAs related to diseases has become a hot topic in the bioinformatics community recently. In this study, we proposed a mathematical model based on matrix decomposition, named MFMDA, to identify potential miRNA-disease associations by integrating known miRNA and disease-related data, similarities between miRNAs and between diseases. We also compared MFMDA with some of the latest algorithms in several established miRNA disease databases. MFMDA reached an AUC of 0.9061 in the fivefold cross-validation. The experimental results show that MFMDA effectively infers novel miRNA-disease associations. In addition, we conducted case studies by applying MFMDA to three types of high-risk human cancers. While most predicted miRNAs are confirmed by external databases of experimental literature, we also identified a few novel disease-related miRNAs for further experimental validation.
Pontine Myelinolysis Caused by Hypovolemic Hypernatremia
Authors: D O Beraldo, S B C P Duarte, R B Santos, C G Mendes, M P Silveira, A S Neto, M M Silva, L G Oliveira, A V Bonfim, A A Teixeira, R A Teixeira
Journal: Case Rep Nephrol (2020)
MeSH terms: Case Reports

Introduction. Central pontine myelinolysis is characterized by the occurrence of acute demyelinating lesions of cells in the pons secondary to abrupt oscillations of serum osmolarity. Its exact incidence is not well defined, but studies show a prevalence of 0.25 to 0.5% in the general population, 2.5% in the intensive care unit, and up to 10% in patients with risk factors, such as chronic liver disease and hepatic transplantation, alcoholism, malnutrition, diuretic therapy, electrolyte imbalance, hypoglycemia, and hyperglycemia. Case Report. A 70-year-old white female with extranodal diffuse large B-cell non-Hodgkin's lymphoma (extensive mass on the left anterior chest wall), stage IVA, developed pontine myelinolysis secondary to hypovolemic acute hypernatremia, which occurred due to diarrhea caused by chemotherapy (rituximab, cyclophosphamide, doxorubicin, and vincristine). Discussion. Pontine myelinolysis occurs most often due to the rapid correction of chronic hyponatremia. But here, we describe a case of the disease secondary to the occurrence of hypovolemic acute hypernatremia in a patient with a hematological malignancy under treatment, who was on chronic treatment with thiazide diuretics and who presented with other electrolyte disturbances as risk factors for the development of pontine myelinolysis.
Degenerative Disorder of the Temporomandibular Joint Treated With Autologous Bone Marrow-Derived Stem Cells Using the Regentime Technique: A Case Report
Authors: Rita T Boulos, Cynthia F Najjoum, Elsa A El Asmar, Nassim H Abi Chahine
Journal: Cureus (2023)
Keywords: autologous mononuclear stem cells, bone marrow-derived stem cells, regentime therapy, stem cell therapy, temporomandibular joint degeneration, tmj disorders
MeSH terms: Case Reports

Temporomandibular joint (TMJ) disease is a type of degenerative musculoskeletal disorder that leads to morphological and functional abnormalities. It has a poorly understood progression with numerous independent and interrelated factors, which makes it difficult for the available treatment options to meet long-term demands. We present the case of a 37-year-old woman who suffered from excruciating pain in the right temporomandibular joint, associated with limited mandibular movement. She was found to have imaging features of TMJ disorder. She underwent the Regentime procedure which uses autologous bone marrow-derived stem cells that are partially differentiated and redirected to the targeted tissue. Clinical follow-up showed total clinical recovery.
In-Hospital Onset of Pseudothrombocytopenia Days before Surgery
Authors: Luiz Souza, Luiz Amorim, Ana Pereira
Journal: Case Rep Anesthesiol (2018)
MeSH terms: Case Reports

Automated cell counters often produce spuriously low platelet counts due to laboratory artifacts. These in vitro phenomena may lead to erroneous treatments, surgical delays, and unnecessary platelet transfusions. An overlooked case of newly developed anticoagulant-induced platelet aggregation diagnosed in a preoperative visit is discussed and diagnostic clues are presented.
Echocardiogram: The GPS to GPA's Heart (Granulomatosis with Polyangiitis)
Authors: Manpreet K Parmar, Mariam Alikhan, Vivien M Hsu, Amanda Borham
Journal: Case Rep Rheumatol (2019)
MeSH terms: Case Reports

Granulomatosis with polyangiitis (GPA) is a rare ANCA-associated necrotizing granulomatous vasculitis affecting small- to medium-sized vessels. Common manifestations of this disease process affect the ear, nose, throat, upper and lower airways, and kidneys. Cardiac involvement has been reported in 6-44% of patients, primarily as coronary arteritis and pericarditis. A majority of case reports of pericardial effusions in patients with GPA identify patients having constrictive pericarditis secondary to uremia. We are presenting a case of hemorrhagic pericarditis in a patient with GPA in which the underlying inflammatory vasculitis likely played the primary role in the patient's presentation. Echocardiographic abnormalities have been found in 80% of patients with GPA. Given the high mortality from cardiac involvement in patients with GPA, screening echocardiograms for this patient population may serve as a helpful tool in gauging disease severity, thereby guiding therapy to prevent serious cardiac complications, such as cardiac tamponade as presented in this case report.
Preoperative Fasting Guidelines in Children: Should They Be Revised?
Authors: Hazem Kafrouni, Rami El Ojaimi
Journal: Case Rep Anesthesiol (2018)
MeSH terms: Case Reports

Children presenting with ingestion of foreign bodies need gastroscopy as a primary management modality. A controversy lies regarding guidelines for preoperative fasting among children with low risk of aspiration and intraoperative complications. This case report represents cases of children who ingested foreign bodies and underwent fasting at different times preoperatively. With mounting evidence questioning the benefits of long durations of fasting in decreasing the risk of aspiration and with studies showing that fasting for more than 2 hours after ingestion of clear fluid does not significantly alter gastric pH or volume, these incidental findings raise the question of whether it is safe to keep children NPO, for a shorter duration before the administration of anesthesia. In addition, this report shows that current guidelines are in need of revision.
Complete Resolution of a Large Bicuspid Aortic Valve Thrombus with Anticoagulation in Primary Antiphospholipid Syndrome
Authors: Rayan Jo Rachwan, Ghassan E Daher, Jawad Fares, Rachoin Rachoin
Journal: Front Cardiovasc Med (2017)
Keywords: anticoagulation, antiphospholipid syndrome, aortic valve, echocardiography, thrombosis
MeSH terms: Case Reports

Native aortic valve thrombosis in primary antiphospholipid syndrome (APLS) is a rare entity. We describe a 38-year-old man who presented with neurological symptoms and a cardiac murmur. Transthoracic echocardiography detected a large bicuspid aortic valve thrombus. Laboratory evaluation showed the presence of antiphospholipid antibodies. Anticoagulation was started, and serial echocardiographic studies showed complete resolution of the aortic valve vegetation after 4 months. The patient improved clinically and had no residual symptoms. This report and review of the literature suggests that vegetations in APLS can be treated successfully with conservative treatment, regardless of their size.
Spontaneous postpartum rupture of an intact uterus: a case report
Authors: George Mavromatidis, George Karavas, Chrysoula Margioula-Siarkou, Stamatios Petousis, Ioannis Kalogiannidis, Apostolos Mamopoulos, David Rousso
Journal: J Clin Med Res (2015)
Keywords: postpartum rupture, unscarred uterus, uterine rupture, vaginal delivery
MeSH terms: Case Reports

Rupture of uterus is an obstetrical complication characterized by a breach in the uterine wall and the overlying serosa. We report an unusual case of spontaneous rupture of an unscarred uterus in a 33-year-old woman, a day after her third successful vaginal delivery. A 33-year-old pregnant woman, gravid 3, para 3, was referred to our department at 39 gestational week because of rupture of membranes. Despite tocolysis administration, her pregnancy was delivered vaginally after 2 days, giving birth to a male neonate of 3,020 g with normal Apgar scores at first and fifth minute. Her uterus was intact and gynecological examination after delivery was normal without any potential signs or symptoms of pathology. However, the day following her labor, patient complained of left iliac fossa pain. Her blood tests revealed a CRP value at 27.6 mg/L, whereas the X-rays revealed an extensive impacted fecal mass in the colon. MRI revealed that the left lower myometrial part of the uterus was depicted abrupt, with simultaneous presence of hemorrhagic stuff. The decision of laparotomy was therefore made in order to further evaluate rupture of uterus and properly treat patient. And subtotal hysterectomy was performed. Postoperative follow-up period was not characterized by any complications and patient was finally discharged 4 days after hysterectomy.
Chest x-ray feature of venous air embolism in orthopedic surgery in prone position: A case report
Authors: Yuwu Liu, Qun Gao, Andi Chen, Jian Xiao, Ping Shi
Journal: Front Surg (2023)
Keywords: case report, chest x-ray, esophageal ultrasound, prone position, venous air embolism
MeSH terms: Case Reports

Background:
Venous air embolism (VAE) is a life-threatening event characterized as a series of clinical features of the disease caused by gas entering the venous circulation in the body.
Case presentation:
A 72-year-old male patient with an ankle fracture after trauma was admitted, and complained of chest pain and dyspnea after the ankle fracture resection and internal fixation. His heart rate and blood pressure dropped, and the patient was diagnosed with VAE according to a chest x-ray and clinical features. Cardiopulmonary resuscitation was carried out and the patient's heartbeat recovered; his blood pressure rose to a normal level. The patient was still unconscious and sent to the intensive care unit for continued monitoring and treatment. Unfortunately, the patient discharged himself from the hospital and died 24 h later.
Conclusion:
This case suggests that x-ray may be a potential method for the rapid diagnosis of VAE in a resource-limited setting.
Unusual retrorectal ganglioneuroma: a case report of laparoscopic assisted approach
Authors: Ahmed Bouzid, Anis Belhadj, Ahmed Saidani, Ziad Bokal, Fahd Khefacha, Faouzi Chebbi
Journal: Pan Afr Med J (2021)
Keywords: laparoscopy, case report, ganglioneuroma, retrorectal
MeSH terms: Ganglioneuroma / surgery, Laparoscopy, Rectal Neoplasms / surgery, Case Reports, Female, Ganglioneuroma / diagnostic imaging, Ganglioneuroma / pathology, Humans, Magnetic Resonance Imaging, Rectal Neoplasms / diagnostic imaging, Rectal Neoplasms / pathology, Ultrasonography, Young Adult

Ganglioneuromas are benign slow-growing lesions that arise from sympathetic ganglion cells. They are usually found incidentally. Ultrasound and magnetic resonance imaging (MRI), provides only an unspecified diagnosis and it has to be confirmed by pathologic studies. Complete surgical excision is believed to be the curative treatment for symptomatic lesions. In the literature, the pelvic location reported is exceptional. We report a case of laparoscopic assisted excision of a retrorectal presacral ganglioneuroma for 22-year-old female patient.
Case Report: A case of hepatocellular carcinoma with aberrant right hepatic artery treated with transarterial chemoembolization and infusion chemotherapy separately to bilobar lesion combining with systemic therapies and sequential hepatectomy
Authors: Yong-Guang Wei, Hao Su, Zi-Li Lv, Xi-Wen Liao, Zhi-Ming Zeng, Yu-Xuan Jia, Hua-Sheng Huang, Xiao-Qiang Shen, Guang-Zhi Zhu, Chuang-Ye Han, Xin-Ping Ye, Tao Peng
Journal: Front Oncol (2023)
Keywords: case report, conversion therapy, hepatic artery variation, hepatocellular carcinoma, interventional therapy
MeSH terms: Case Reports

Background:
Hepatocellular carcinoma (HCC) with a dismal prognosis is the second most deadly malignancy globally. Surgery is believed to be a curative approach. Nevertheless, there is still a considerable probability of postoperative recurrence. Most patients present in advanced stages with a surgically and oncologically unresectable disease. Systemic medicines are increasingly important to downstage the disease and further improve survival.
Case summary:
A 67-year-old Chinese man with uncontrolled hepatitis B was discovered to have liver masses with abnormal serum vitamin K absence or antagonist-II (PIVKA-II) level during checkup for upper abdominal discomfort. Abdominal multiphase computerized tomography (CT) and gadoxetate disodium-enhanced magnetic resonance imaging (MRI) showed the bulky bilobar HCCs of Barcelona Clinic Liver Cancer stage B and China Liver Cancer Staging stage IIa. Furthermore, the aberrant right hepatic artery (RHA) originates from the superior mesenteric artery. Due to the location being adjacent to important vasculatures and massive size of the right-sided lesion, curative resection appears to be challenging. To achieve a favorable surgical margin, repeated hepatic arterial infusion chemotherapy (HAIC) was adopted through the variant RHA, while transarterial chemoembolization (TACE) was delivered to the left lobe to arrest tumor growth. Furthermore, sintilimab plus lenvatinib served as the sequential systemic therapy. After 5 months of conversion treatment, the partial response with a decreased serum PIVKA-II level was attained. The R0 hepatectomy was then performed without postoperative complications. The immunohistochemistry and next-generation sequencing results suggested that the two-side HCCs existing tumor heterogeneity were not completely consistent. The patient continues to be without evidence of disease.
Conclusion:
Our case highlights a favorable outcome in a man with bilobar bulky HCC after undergoing the comprehensive therapeutic schedule that includes personalized intervention and systemic drug therapy. In terms of conversion therapy, our case provides a secure and practical reference for managing unresectable bilobar HCC coexisting with the aberrant hepatic artery.
Liposarcoma of the spermatic cord presenting as an inguinal hernia
Authors: Eric Wetzel, Norair Adjamian, Graal Diaz, Shawn Steen, Janet Hobbs
Journal: Int J Surg Case Rep (2020)
Keywords: case report, inguinal orchiectomy, liposarcoma, spermatic cord
MeSH terms: Case Reports

Introduction:
Dedifferentiated liposarcoma is a rare, highly malignant, rapidly recurring tumor. When found in the spermatic cord, this tumor may deceptively present as an inguinal hernia, and due to its rarity, may not be readily identified.
Presentation of case:
We report a case of a 46-year old man with dedifferentiated liposarcoma presenting as a slow-growing right inguinal bulge. His surgical management included ipsilateral orchiectomy and excision with wide margins. He received adjuvant focused radiation therapy.
Conclusion:
Liposarcoma of the Spermatic Cord is a rare and highly malignant tumor that rapidly recurs. Therefore, a high degree of suspicion, regular surveillance and imaging are justified.
Elective Cesarean Section during Preterm Prevents Pulmonary Hypoplasia Development in Potter Sequence
Authors: Yuya Kinoshita, Rieko Sakamoto, Yusuke Hattori, Keishiro Furuie, Shohei Kuraoka, Yuko Hidaka, Hiroshi Tamura, Hiroshi Mitsubuchi, Kimitoshi Nakamura
Journal: Case Rep Pediatr (2023)
MeSH terms: Case Reports

Potter syndrome, first reported in 1946 by Edith Potter, refers to fatal cases of bilateral renal aplasia with pulmonary hypoplasia, peculiar facial features, and limb deformities. Presently, patients with oligohydramnios showing similar pathological manifestations due to oligohydramnios caused by conditions other than bilateral renal aplasia have been reported, and are known as the Potter sequence. There are limited studies and unclear guidelines on the safest delivery time and detailed postpartum management for patients with the Potter sequence. We experienced a case of Potter sequence, in which the patient was born by elective cesarean section at gestational age (GA) of 34 weeks. Fetal ultrasound at GA of 26 weeks 4 days showed oligohydramnios, multilocular cystic lesions in the left kidney, and an absent right kidney. Prenatal fetal MRI at GA of 33 weeks and 3 days showed pulmonary hypoplasia, and the ratio of fetal lung volume (FLV) to fetal body weight (FBW) was 0.0135 ml/g. We suspected that the fetal lung could not grow because of persistent oligohydramnios, which leads to a further decline in the ratio of FLV to FBW during pregnancy. We performed a cesarean section at GA of 34 weeks to prevent the exacerbation of the imbalance between lung volume and physique. We struggled to keep her condition stabilized with strict management of her respiratory condition, dialysis, and nutrition. She was discharged from the hospital at 169 days of age. Elective caesarean section in the term of premature birth prevented the progression of pulmonary hypoplasia and made it possible to save her life. Potter sequence is still relatively unknown, and it is necessary for more studies to be conducted in the future.
T-cell lymphoma with rhabdomyolysis: case report and literature review
Authors: Zhao-Zhong Ouyang, Ting-Sheng Peng, Qing-Hua Cao, Yin Ouyang, Jun-Xun Li, Qiu-Xiang Wei, Hong Zhan
Journal: Braz J Med Biol Res (2018)
MeSH terms: Bone Marrow Neoplasms / complications, Lymphoma, T-Cell / complications, Rhabdomyolysis / etiology, Case Reports, Review, Acute Kidney Injury / etiology, Adult, Biopsy, Needle, Bone Marrow / pathology, Bone Marrow Neoplasms / pathology, Fatal Outcome, Female, Humans, Immunohistochemistry, Lymphoma, T-Cell / pathology

Rhabdomyolysis refers to the destruction or disintegration of striated muscles. This syndrome is characterized by muscle breakdown and necrosis, resulting in the leakage of intracellular muscle constituents into the circulation and extracellular fluid. We report a rare case of rhabdomyolysis complicating multi-organ failure caused by T-cell lymphoma in a 32-year-old woman. The final diagnosis was rhabdomyolysis caused by peripheral T-cell lymphoma based on bone marrow aspirate and biopsy.
Pseudohypoadrenocorticism in a Siberian Husky with Trichuris vulpis Infection
Authors: Stephanie Car, Catriona Croton, Mark Haworth
Journal: Case Rep Vet Med (2019)
MeSH terms: Case Reports

An entire male Siberian Husky presented for diarrhoea, weakness, inappetence, and collapse following a six-day period of illness. On clinical examination the dog displayed vasoconstrictive circulatory shock, dehydration, and melena. Laboratory tests revealed a marked hyponatraemia, hyperkalaemia, and a decreased sodium/potassium ratio of ≤ 12.4. The baseline and poststimulation serum cortisol concentrations were markedly elevated following adrenocorticotropin hormone (ACTH) stimulation test, yielding 712 nmol/L and 706 nmol/L, respectively. The elevated cortisol concentration excluded hypoadrenocorticism. A concurrent Trichuris vulpis (whipworm) infection was also identified. The dog was treated with supportive care including fenbendazole and recovered uneventfully. The final diagnosis was Trichuris vulpis infection with secondary pseudohypoadrenocorticism. This case report further supports a previous observation that the Siberian Husky breed may have an increased sensitivity to infection with Trichuris vulpis and development of pseudohypoadrenocorticism.
Sustained Complete Response to Metronomic Chemotherapy in a Child with Refractory Atypical Teratoid Rhabdoid Tumor: A Case Report
Authors: Mahe Berland, Laetitia Padovani, Angélique Rome, Grégoire Pech-Gourg, Dominique Figarella-Branger, Nicolas André
Journal: Front Pharmacol (2017)
Keywords: atrt, brain tumor, drug repurposing, metronomic chemotherapy, pediatric oncology, pharmaceutical preparations

Atypical teratoid rhabdoid tumor (ATRT) is a rare and highly aggressive embryonal tumor of the central nervous system with a dismal prognosis and no definitive guidelines for treatment, especially at relapse or in case of refractory disease. Metronomic chemotherapy (MC) has emerged as a new treatment option in solid malignancies, with lower toxicity and is frequently combined with drug repositioning. We report a case of ATRT in an 8-year-old boy who progressed during multimodal therapy including surgical resection, chemotherapy and radiotherapy. He was treated with MC involving continuous oral celecoxib with alternating metronomic etoposide and cyclophosphamide, in combination with biweekly bevacizumab and monthly intrathecal liposomal cytarabine. To date, he remains clinically and symptomatically disease-free with a follow-up of 10 months. The treatment was well-tolerated. Metronomics represent a possible alternative regimen for children with recurrent or progressive ATRT.
Unusual Ovarian Vein Thrombosis Associated with Urinary Tract Infection: A Case Report
Authors: Beom Kyun Pak, In O Sun, Dong Min Kang
Journal: J Belg Soc Radiol (2022)
Keywords: multidetector computed tomography, thrombophlebitis, urinary tract infections, urogenital disease, venous thrombosis
MeSH terms: Case Reports

Teaching Point: Radiologists need to be familiar with that ovarian vein thrombosis can occur as a complication of urinary tract infection. Ovarian vein thrombosis is a rare disease in which a majority of cases occur during the postpartum period. There are few case reports for ovarian vein thrombosis associated with urinary tract infection in non-postpartum women. We report a case of ovarian vein thrombosis incidentally diagnosed on computed tomography in a patient with symptoms of urinary tract infection.