OpenMed/multicare-articles huggingface dataset:
Primary renal mucinous adenocarcinoma masquerading as a giant renal cyst: a case report
Authors: Hong Zeng, Mengni Zhang, Yandong Xie, Minghao Wang, Jindong Dai, Xudong Zhu, Yuhao Zeng, Nanwei Xu, Peng Huang, Jinge Zhao, Guangxi Sun, Hao Zeng, Pengfei Shen
Journal: Front Oncol (2023)
Keywords: case report, diagnosis, follow-up, mucinous adenocarcinoma, postoperative treatment, renal parenchyma
MeSH terms: Case Reports

Mucinous adenocarcinoma of the kidney is rarely reported in the literature. We present a previously unreported mucinous adenocarcinoma arising from the renal parenchyma. A 55-year-old male patient with no complaints showed a large cystic hypodense lesion in the upper left kidney on contrast-enhanced computed tomography (CT) scan. A left renal cyst was initially considered, and a partial nephrectomy (PN) was performed. During the operation, a large amount of jelly-like mucus and bean-curd-like necrotic tissue was found in the focus. The pathological diagnosis was mucinous adenocarcinoma, and further systemic examination revealed no clinical evidence of primary disease elsewhere. Then the patient underwent left radical nephrectomy (RN), and the cystic lesion was found in the renal parenchyma, while neither the collecting system nor the ureters were involved. Postoperative sequential chemotherapy and radiotherapy were administered, and no signs of disease recurrence were observed over 30 months of follow-up. Based on a literature review, we summarize the lesion with rarity and the associated dilemma in preoperative diagnosis and treatment. Given the high degree of malignancy, a careful history analysis accompanied by dynamic observation of imaging and tumor markers is recommended for the diagnosis of the disease. Comprehensive treatment based on surgery may improve its clinical outcomes.
A Rare Case of Deep Digital Flexor Tendinopathy following Centesis of the Navicular Bursa
Authors: Tim J Froydenlund, Lucinda J Meehan, Linda R Morrison, Raphael Labens
Journal: Front Vet Sci (2017)
Keywords: centesis, deep digital flexor tendinopathy, foot, horse, navicular bursa
MeSH terms: Case Reports

Navicular bursa (NB) centesis is a common diagnostic and therapeutic procedure in equine practice. This case report documents the clinical, diagnostic imaging and histological findings in a horse with a suspected iatrogenic deep digital flexor tendon (DDFT) injury following centesis of the NB via a modified distal plantar approach (placement of two needles in a weight bearing position). Although it cannot be proven with absolute certainty, the authors believe that this is the first reported case where NB centesis is the likely cause of a DDFT lesion, and with magnetic resonance imaging performed both pre- and post-centesis. With this potential, though rare, complication of the procedure, alternative tendon sparing injection techniques should be considered prior to NB centesis in certain cases.
Case report: B7-H3 CAR-T therapy partially controls tumor growth in a basal cell carcinoma patient
Authors: Gang Hu, Guangchao Li, Wei Wen, Wen Ding, Zhao Zhou, Yongwei Zheng, Taoyuan Huang, Junnan Ren, Rongyi Chen, Dingheng Zhu, Renliang He, Yunsheng Liang, Min Luo
Journal: Front Oncol (2022)
Keywords: b7-h3, car-t cell therapy, cd276, basal cell carcinomas, intratumoral injection, skin cancers
MeSH terms: Case Reports

B7-H3 is over-expressed in multiple types of solid tumors, making it an ideal target for chimeric antigen receptor (CAR)-T therapy. Here, we first report a case of multiple basal cell carcinoma (BCC) patient treated with humanized monoclonal anti-B7-H3 CAR-T cells through direct intratumoral injection. After three dose-escalated injections, the lesion in the abdomen decreased by 40% in volume, shrank from bulging to flat, but was not eradicated completely. The large lesion in the forehead became dry from original ulcer and bleeding. The adverse events observed were itching, myalgia, and redness. Immunohistochemistry analysis demonstrated that B7-H3-positive tumor cells and B7-H3 expression intensity were reduced after injections of CAR-T cells. The number of infiltrating CD3 T cells increased significantly but mainly located outside the tumor region. Subsequently, high levels of TGF-β in the tumor area were observed, suggesting that solid tumor microenvironment may hinder the infiltration and effect of CAR-T cells. In summary, in this particular case report, intratumoral injection of B7-H3 CAR-T cells partially controls tumor growth in the BCC patient with minor adverse events. The efficacy and safety of B7-H3 CAR-T therapy need to be further investigated with a larger cohort of patients. Although only one clinical case is reported here, the anti-B7-H3 CAR-T cell therapy should be considered as a treatment option for solid tumors in the future. This clinical trial was registered at the Chinese Clinical Trial Registry (www.chictr.org.cn) with registration number ChiCTR2100044386.
Liposarcoma of the spermatic cord: a rare entity
Authors: Fazl Qadir Parray, Rayees Ahmad Dar, Nisar Ahmad Chowdri, Arif Hamid, Rayees Ahmed Malik
Journal: Case Rep Urol (2011)
MeSH terms: Case Reports

Primary malignant tumours of spermatic cord are rare. The liposarcoma of spermatic cord is a rare entity and only a few cases have been reported in the literature. We report a case of forty five-year-old male with huge left inguinoscrotal swelling. Fine needle aspiration cytology (FNAC) of swelling revealed the diagnosis of a liposarcoma. The patient was subjected to radical orchidectomy and wide excision. Histopathological examination (HPE) of the resected specimen reported a well-differentiated liposarcoma of the spermatic cord and confirmed the diagnosis.
An Atypical Case of Rickettsial Spotted Fever Myocarditis Mimicking Weil's Disease
Authors: N D B Ehelepola, G D N R Kumara, S A C S Sapurugala, W M N P Buddhadasa, Wasantha P Dissanayake
Journal: Case Rep Infect Dis (2019)
MeSH terms: Case Reports

A 65-year-old previously healthy male presented to us on the fourth day of a febrile illness with headache, arthralgia, myalgia, nausea, cough, chest pain, sore throat, and passing of watery stools and dark urine with a history of exposure to leptospirosis during a dengue outbreak. On examination, there was dehydration and hypovolemia, and an ultrasound scan revealed capillary leakage. His liver transaminases, serum creatine, blood urea, C-reactive protein, and neutrophil percentage were high, and thrombocytopenia was present. Moreover, myocarditis has been detected too. Supportive therapy with intravenous ceftriaxone was administered, considering possible Weil's disease or dengue hemorrhagic fever with secondary bacterial infection. Serological tests, performed later, diagnosed him with a Rickettsia conorii infection and excluded dengue, leptospirosis, and hantavirus infections. Repeat 2D echocardiograms showed mild improvement of his cardiac failure after one month and a more improvement after eight months. Clinical features of the rickettsial spotted fever group (SFG) and leptospirosis overlap. Leptospirosis is common; thus, the risk of overlooking SFG and diagnosing leptospirosis is likely. Tests for differentiation are unavailable in Sri Lankan hospitals and in many other developing countries. Empirical doxycycline in suspected cases of SFG infections in areas where rickettsioses are prevalent can save lives as in this case.
Myeloid Neoplasms with t(5;12) and ETV6-ACSL6 Gene Fusion, Potential Mimickers of Myeloid Neoplasm with PDGFRB Rearrangement: Case Report with Imatinib Therapy and Review of the Literature
Authors: Javier De Luca-Johnson, Jose I Ruades Ninfea, Lauren Pearson, Joanna Conant, Ronald Bryant, Neil A Zakai, Mary E Tang
Journal: Case Rep Med (2016)

We report the second case of ETV6-ACSL6 associated myeloproliferative neoplasm that has received a full course of imatinib therapy. The patient was a 51-year-old previously healthy man who presented with three months of worsening dyspnea and was found to have a white count of 216,000/cmm, of which 84% were eosinophil lineage. Cytogenetic analysis revealed a t(5;12)(q31~33;p13). FISH was negative for PDGFRB rearrangement but additional FISH testing demonstrated an ACSL6 rearrangement. ETV6-ACSL6 gene fusion is a rare abnormality that most often presents as a myeloproliferative-type disorder with prominent eosinophilia or basophilia. Review of the literature yielded a total of 11 previous cases. This gene fusion results in a t(5;12)(q31~33;p13) that mimics the t(5;12) found in ETV6-PDGFRB neoplasms. Identification of the fusion genes involved in t(5;12) in eosinophilia-associated myeloproliferative disorders is crucial to direct an effective treatment plan. In particular, while tyrosine kinase inhibitor therapy is effective in patients with PDGFRB rearrangement, there is little information on imatinib efficacy in patients with ETV6-ACSL6 gene fusion. Our patient was found to be nonresponsive to imatinib therapy.
Comparison of two algorithms for determining beam weights and wedge filters
Authors: Jianrong Dai, Yunping Zhu
Journal: J Appl Clin Med Phys (2002)
MeSH terms: Algorithms, Radiotherapy, Conformal / methods, Comparative Study, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Feasibility Studies, Humans, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted / methods

This article compares two algorithms for determining beam weights and wedge filters for conformal treatment planning. One algorithm, which is based on dose-gradient analysis, provides analytic formulas for determining beam weights, wedge angles, and collimator angles (i.e., wedge orientations) so that the dose distribution is homogeneous in the target volume. The second algorithm is based on the concept of the super-omni wedge (i.e., the arrangement of two pairs of orthogonal nominal wedged beams), numerically optimize beam weights, wedge angles, and collimator angles so that the dose requirements to targets and organs at risk are satisfied to the best. Three clinical cases were tested. For the first case, both algorithms resulted in comparable homogeneous dose distributions in the target volume. For the second case, the second algorithm resulted in much lower doses to the eyes plus a better homogeneous dose distribution in the target volume. For the third case, only the second algorithm was applicable, and the treatment plan it developed met the prescribed requirements. The results show that the first algorithm is better in terms of feasibility, whereas the second is better in terms of applicability and the quality of treatment plans.
Case Report: Incidentally Discovered a Rare Cystic Lesion of Liver: Multicystic Biliary Hamartoma
Authors: Wentao Mu, Peng Su, Shanglei Ning
Journal: Pathol Oncol Res (2021)
Keywords: cystic lesion of liver, immunohistochemistry, laparoscopic resection, liver, multicystic biliary hamartoma
MeSH terms: Bile Duct Neoplasms / pathology, Bile Ducts, Intrahepatic / pathology, Cysts / pathology, Hamartoma / pathology, Incidental Findings, Case Reports, Adult, Bile Duct Neoplasms / complications, Bile Duct Neoplasms / surgery, Bile Ducts, Intrahepatic / surgery, Cysts / complications, Cysts / surgery, Hamartoma / complications, Hamartoma / surgery, Hepatectomy, Humans, Male, Prognosis

Multicystic biliary hamartoma (MCBH) is an extremely rare cystic lesion of the liver. A 37-year old male patient was admitted to our hospital for incidentally discovered hepatic cystic lesions on abdominal ultrasonography. Abdominal contrast-enhanced computed tomography (CT) showed a multilocular cystic lesion in the segment VI, with mild enhancement in the septae and peripheral wall within the lesion. Only alanine transaminase (ALT) and carbohydrate antigen 19-9 (CA19-9) increased slightly above normal value. Preoperative tests suggested possibility of a benign mucinous cystic neoplasm (MCN) or intraductal papillary neoplasm of the bile duct (IPNB). Laparoscopic complete resection of the lesion was performed. Histopathological examination showed numerous variably sized ductal structures surrounded by periductal glands and fibrous connective tissues containing small blood vessels and smooth muscle bundles. Immunohistochemical staining (IHC) revealed that dilated ducts were positive for cytokeratin CK19, characteristic for biliary tract. Histopathological findings confirmed diagnosis of multicystic biliary hamartoma (MCBH). No recurrence occurred during 6 months follow-up. In conclusion, MCBH should be differentiating from hepatic cystic lesion and could be resected laparoscopically safely.
Patellar osteoid osteoma as a cause of anterior knee pain in adolescents: a case report and literature review
Authors: Claudio Chillemi, Vincenzo Franceschini, Massimiliano D'Erme, Giorgio Ippolito, Pasquale Farsetti
Journal: Case Rep Med (2013)

Anterior Knee Pain (AKP) is an important cause of complaint in adolescents which can suggest many possible diseases. Scientific literature concerning this complex symptom is wide and diversified. We report a rare case of patellar osteoid osteoma which affected a thirteen-year-old female who had suffered from anterior left knee pain for almost six months. The diagnosis was suspected from an accurate anamnesis, a careful clinical examination, and confirmed by imaging. Several minimally invasive techniques can be employed to treat osteoid osteoma. However, we consider CT-guided percutaneous drilling the safest and most effective procedure in case of patellar location. Despite its rarity, patellar osteoid osteoma ranges in the differential diagnosis for all patients suffering from AKP.
A rare cause of myocardial infarction and ventricular tachycardia in a young male with HIV/AIDS - spontaneous coronary artery dissection: A case report
Authors: Krishna Prasad, Tanushi Aggarwal, Prashant Panda, Ganesh Kasinadhuni, Yash Paul Sharma
Journal: J Cardiovasc Thorac Res (2022)
Keywords: acquired immunodeficiency syndrome, human immunodeficiency virus, spontaneous coronary artery dissection, ventricular tachycardia
MeSH terms: Case Reports

HIV/AIDS is a multisystemic disorder and occurrence of cardiovascular disease is higher compared to non-HIV individuals. Spontaneous coronary artery dissection (SCAD) remains a rare and underdiagnosed cause of acute coronary syndrome (ACS), even in modern day era. SCAD is predominantly seen in young to middle aged females and present as a non-atherosclerotic cause of myocardial ischaemia, infarction or sudden cardiac death (SCD); with or without ventricular arrythmias. Ventricular tachycardia (VT) can sometimes be the initial presentation of SCAD. HIV associated arteriopathy can predispose to occurrence of SCAD. We report a case of a 38-year-old male suffering from HIV/AIDS, with no conventional risk factors presenting as VT. Coronary angiogram showed SCAD in right coronary artery without any flow limitation.
Managing terminal restlessness, anxiety, and distress during the dying process with Yintang (EX-HN 3) point acupuncture or acupressure: a case series of 19 palliative care patients from a hospital in Germany
Authors: Angeliki Konstantinou, Lykourgos Christos Alexakis
Journal: Pan Afr Med J (2022)
Keywords: acupuncture, yintang (ex-hn 3), yintang point, acupressure, acupuncture therapy, palliative care, palliative medicine, terminal care
MeSH terms: Acupressure, Acupuncture Therapy, Case Reports, Anxiety, Hospitals, Humans, Palliative Care, Psychomotor Agitation

This is a case series report of 19 palliative care patients where 23 acupuncture sessions were performed which included Yintang (EX-HN 3) acupuncture or acupressure for the relief of terminal restlessness, anxiety or psychological distress present during the dying process. There was an observable relief from the restlessness, anxiety and distress both in sessions where only Yintang (EX-HN 3) point acupuncture or acupressure was performed (observed in 10 out of 11 sessions) as well as in sessions where Yintang (EX-HN 3) point acupuncture or acupressure was performed together with additional interventions, such as other points acupuncture, ear acupuncture or benzodiazepine treatment (observed in 10 out of 12 sessions). In total relief was observed in 20 out of 23 sessions (86.9%). A hypothesis that might worth further testing is whether Yintang (EX-HN 3) acupuncture or acupressure has an anxiolytic, tranquillising or sedative effect in dying patients. If confirmed this could be potentially useful in the fields of palliative care or disaster/triage medicine.
Severe Anemia and Helicobacter Pylori Infection in school age Children; A case reports
Authors: Sh Gheibi, M Noroozi, S Hejazi, M Karamyyar, H Farrokh-Eslamlou
Journal: Iran J Ped Hematol Oncol (2016)
Keywords: helicobacter pylor, iron deficiency, severe iron deficiency anemia
MeSH terms: Case Reports

Background:
Iron-deficiency anemia is a widespread public health problem with major consequences for human health especially, children. However, in a fraction of patients an underlying cause is never found during routine investigation. Recent studies have suggested an association between Helicobacter pylori (H. Pylori) infection and iron-deficiency anemia.
Case presentation:
Here is reported four school aged children (two male, two female) with refractory severe iron-deficiency anemia associated H. Pylori gastritis. Mean age of the patients was 13.62 years old and they were admitted with chief complaints of abdominal, chest pain weakness, headache and respiratory distress. Mean hemoglobin level in patients was 6.2 g/dl with persistence to iron therapy. After the diagnosis and therapy of H. pylori infection, clinical complaints, hemoglobin level and iron profiles were being normal and they gained weight.
Conclusion:
This study suggests screening of H. pylori infection and appropriate treatment in any case of refractory moderate to severe iron-deficiency anemia, especially with clinical manifestations of gastrointestinal tract in children.
Forty years abuse of baking soda, rhabdomyolysis, glomerulonephritis, hypertension leading to renal failure: a case report
Authors: Terje Forslund, Arvo Koistinen, Jorma Anttinen, Bodo Wagner, Marja Miettinen
Journal: Clin Med Case Rep (2008)
Keywords: baking soda intoxication, end-stage renal failure, glomerulonephritis, hypertension, rhabdomyolysis
MeSH terms: Case Reports

We present a patient who had ingested sodium bicarbonate for treatment of alcoholic dyspepsia during forty years at increasing doses. During the last year he had used more than 50 grams daily. He presented with metabolic alkalosis, epileptic convulsions, subdural hematoma, hypertension and rhabdomyolysis with end stage renal failure, for which he had to be given regular intermittent hemodialysis treatment. Untreated hypertension and glomerulonephritis was probably present prior to all these acute incidents. Examination of the kidney biopsy revealed mesangial proliferative glomerulonephritis and arterial wall thickening causing nephrosclerosis together with interstitial calcinosis. The combination of all these pathologic changes might be responsible for the development of progressive chronic renal failure ending up with the need for continuous intermittent hemodialysis treatment.
Rare Presentation of Pulmonary Alveolar Proteinosis Causing Acute Respiratory Failure
Authors: Ryan R Kroll, Sameer Kumar, Ronald F Grossman, Charles Price, John R Srigley
Journal: Can Respir J (2016)
MeSH terms: Pulmonary Alveolar Proteinosis / diagnostic imaging, Radiography, Thoracic, Respiratory Insufficiency / etiology, Tomography, X-Ray Computed, Case Reports, Bronchoalveolar Lavage, Female, Humans, Middle Aged, Pulmonary Alveolar Proteinosis / complications, Pulmonary Alveolar Proteinosis / therapy

Pulmonary alveolar proteinosis (PAP) is a rare condition characterized by dysfunctional alveolar macrophages, which ineffectively clear surfactant and typically cause mild hypoxemia. Characteristic Computed Tomography findings are septal reticulations superimposed on ground-glass opacities in a crazy paving pattern, with a clear juxtaposition between affected and unaffected parenchyma. While traditionally PAP was diagnosed via biopsy, bronchoalveolar lavage (BAL) is usually sufficient; the fluid appears milky, and on microscopic examination there are foamy macrophages with eosinophilic granules and extracellular hyaline material that is Periodic Acid-Schiff positive. Standard therapy is whole lung lavage (WLL), although novel treatments are under development. The case presented is a 55-year-old woman with six months of progressive dyspnea, who developed hypoxemic respiratory failure requiring mechanical ventilation; she had typical findings of PAP on imaging and BAL. WLL was ultimately successful in restoring adequate oxygenation. Respiratory failure of this magnitude is a rare finding in PAP.
Case Report: Preliminary Images From an Electromagnetic Portable Brain Scanner for Diagnosis and Monitoring of Acute Stroke
Authors: David Cook, Helen Brown, Isuravi Widanapathirana, Darshan Shah, James Walsham, Adnan Trakic, Guohun Zhu, Ali Zamani, Lei Guo, Aida Brankovic, Ahmed Al-Saffar, Anthony Stancombe, Alina Bialkowski, Phong Nguyen, Konstanty Bialkowski, Stuart Crozier, Amin Abbosh
Journal: Front Neurol (2021)
Keywords: electromagnetic neuroimaging, electromagnetic stroke imaging, mobile brain scanner, mobile neuroimaging, mobile stroke imaging
MeSH terms: Case Reports

Introduction: Electromagnetic imaging is an emerging technology which promises to provide a mobile, and rapid neuroimaging modality for pre-hospital and bedside evaluation of stroke patients based on the dielectric properties of the tissue. It is now possible due to technological advancements in materials, antennae design and manufacture, rapid portable computing power and network analyses and development of processing algorithms for image reconstruction. The purpose of this report is to introduce images from a novel, portable electromagnetic scanner being trialed for bedside and mobile imaging of ischaemic and haemorrhagic stroke. Methods: A prospective convenience study enrolled patients (January 2020 to August 2020) with known stroke to have brain electromagnetic imaging, in addition to usual imaging and medical care. The images are obtained by processing signals from encircling transceiver antennae which emit and detect low energy signals in the microwave frequency spectrum between 0.5 and 2.0 GHz. The purpose of the study was to refine the imaging algorithms. Results: Examples are presented of haemorrhagic and ischaemic stroke and comparison is made with CT, perfusion and MRI T2 FAIR sequence images. Conclusion: Due to speed of imaging, size and mobility of the device and negligible environmental risks, development of electromagnetic scanning scanner provides a promising additional modality for mobile and bedside neuroimaging.
Mammary Analogue Secretory Carcinoma of the Palate: Case Report and Review of the Literature
Authors: Christian Boliere, James Murphy, Mohammed Qaisi, Frances Manosca, Henry Fung
Journal: Case Rep Dent (2019)
MeSH terms: Case Reports

Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor, with a limited number of published reports. Less than three hundred cases have been reported in the literature and only 18 of these cases have been reported in minor palatal salivary glands, though publication bias is likely a factor. We present a case of a 57-year-old male who was diagnosed with MASC tumor presenting in a minor salivary gland and briefly review the current literature. MASC has a variety of histological features and different range of clinical behaviors. The histopathological diagnosis of MASC can be difficult, and the immunohistochemical profile of MASC is still being updated. The gold standard for MASC diagnosis is cytogenetics, with the majority having a translocation t(12;15)(p133;q25). Presently, there is no conclusive evidence that MASC should be treated differently than any other low-grade malignant salivary gland tumors, though high-grade transformation has been described.