OpenMed/multicare-articles huggingface dataset:
Community Case Study on Trauma-Specific Treatment and Counseling for Refugee Women Exposed to Intimate Partner Violence
Authors: Anneke Pogarell, Susan Garthus-Niegel, Amera Mojahed, Clara von Verschuer, Ute Rokyta, Wenke Kummer, Julia Schellong
Journal: Front Psychiatry (2019)
Keywords: aid network, counseling, intimate partner violence, mental health, post migration, posttraumatic stress disorder, refugee women, trauma-specific psychotherapy

Women experiencing intimate partner violence (IPV) are at high risk to suffer from severe mental health consequences, such as posttraumatic stress disorder (PTSD) and depression. Refugee women being exposed to IPV in the country of arrival are an especially vulnerable and understudied group and post migration persistent IPV should not be underestimated. Hence, research on special requirements regarding the treatment of these women is needed. We describe two individual cases from our work with refugee women suffering from PTSD symptoms who experienced IPV representing our trauma-specific therapeutic approach targeting this population. By analyzing their personal and medical history as well as their interactions with several institutions of the public sector and counseling centers, we illustrate the possibilities and limitations when helping our clients dealing with trauma-related mental health problems following the experience of IPV. Furthermore, we formulate general recommendations for providing adequate therapeutic frameworks concerning special requirements for the work with refugee women.
Maintenance therapy of low-dose nivolumab, S-1, and leucovorin in metastatic pancreatic adenocarcinoma with a germline mutation of MSH6: A case report
Authors: Shang-Hsuan Peng, Bang-Bin Chen, Ting-Chun Kuo, Jen-Chieh Lee, Shih-Hung Yang
Journal: Front Immunol (2022)
Keywords: case report, maintenance therapy, mismatch repair, nivolumab, pancreatic ductal adenocarcinoma
MeSH terms: Adenocarcinoma / drug therapy, Adenocarcinoma / genetics, Adenocarcinoma / pathology, Pancreatic Neoplasms / drug therapy, Pancreatic Neoplasms / genetics, Case Reports, DNA-Binding Proteins / genetics, Female, Germ-Line Mutation, Humans, Leucovorin / therapeutic use, Middle Aged, Nivolumab / therapeutic use, Nivolumab, Leucovorin, DNA-Binding Proteins, Pancreatic Carcinoma

Immune checkpoint inhibitors (ICIs) provide substantial benefits to a small subset of patients with advanced cancer with mismatch repair deficiency (MMRD) or microsatellite instability (MSI), including patients with pancreatic ductal adenocarcinoma (PDAC). However, the long duration of ICI treatment presents a considerable financial burden. We present the case of a 63-year-old woman with metastatic PDAC refractory to conventional chemotherapy. Genetic analyses identified an MSH6 germline mutation and a high tumor mutation burden (TMB). Complete response (CR) was achieved after a short course of low-dose nivolumab (20 mg once every 2 weeks) with chemotherapy. CR was maintained for over 1 year with low-dose nivolumab and de-escalated chemotherapy without any immune-related adverse events. This case supports the further exploration of low-dose, affordable ICI-containing regimens in patients with advanced MSI-high/TMB-high cancer.
Othello syndrome secondary to ropinirole: a case study
Authors: Kakali Pal, Abigail Smith, Joseph Hayes, Apu Chakraborty
Journal: Case Rep Psychiatry (2012)
MeSH terms: Case Reports

This case report describes a forty-two-year-old man with no previous psychiatric history who developed delusional jealousy (Othello Syndrome) associated with ropinirole treatment. Ropinirole is a commonly used dopamine receptor agonist, which was being used to treat his Parkinson's disease, and his delusional symptoms resolved entirely with ropinirole dose reduction.
Radiosurgery for the treatment of dominant hemisphere periventricular heterotopia and intractable epilepsy in a series of three patients
Authors: Chengyuan Wu, Michael R Sperling, Steven M Falowski, Ameet V Chitale, Maria Werner-Wasik, James J Evans, David W Andrews, Ashwini D Sharan
Journal: Epilepsy Behav Case Rep (2012)
Keywords: epilepsy, periventricular nodular heterotopia (pvh), radionecrosis, stereotactic radiosurgery (srs)

Periventricular heterotopia (PVH) is a neuronal migration disorder characterized by masses of gray matter located along the lateral ventricles that commonly cause epilepsy. The benefit of surgical resection of the PVH has been demonstrated in case reports to date; however, the location of the PVH in the paratrigonal region of the lateral ventricles can present significant surgical challenges. Noninvasive modalities of ablating this epileptogenic focus must therefore be considered. We present a small series of three patients who underwent stereotactic radiosurgery (SRS) for inoperable unilateral dominant hemisphere PVHs in order to illustrate the potential benefits and risks of this treatment modality. A total dose of 37.5-65 Gy resulted in seizure freedom for at least 14 months at the time of their last follow-up, even in patients harboring a second independent epileptic focus. Whether intracranial electrode recording truly offers added value is therefore uncertain. The two patients who received higher radiation doses suffered from symptomatic radiation necrosis and associated cerebral edema, requiring further medical intervention, and persistent monocular visual loss in one patient. While a longer interval prior to re-treatment may have been attempted, neither patient demonstrated radiographic findings typically associated with seizure remission. Refractory epilepsy due to PVH may be successfully treated with radiation therapy; but further work is needed to define the optimal dosing parameters in order to lower toxicity to normal tissue.
Scalp metastasis from leiomyosarcoma of the inferior vena cava sign as the first clinical sign: a case report
Authors: Isabel Prieto Muñoz, Jose Pardo Masferrer
Journal: Case Rep Oncol Med (2012)

The presentation of scalp metastases from leiomyosarcoma of the vena cava is an extremely infrequent event. There are no other publications that describe such finding and very few of leiomyosarcoma in vessels. About this event we have reviewed the English literature describing studies on scalp metastases and skin metastases in general: their incidence, origin, clinical appearance, meaning, and diagnosis. The case we describe would be the second one presented worldwide because, as far as we know, it has been only one more published in 2005.
Intravitreal luxated lens stuck on the optic disc: a case report
Authors: Seita Morishita, Masanori Fukumoto, Hiroyuki Suzuki, Takaki Sato, Teruyo Kida, Eisuke Isizaki, Mari Ueki, Tetsuya Sugiyama, Tsunehiko Ikeda
Journal: J Med Case Rep (2016)
MeSH terms: Lens Subluxation / complications, Optic Disk, Case Reports, Aged, 80 and over, Glaucoma, Angle-Closure / complications, Glaucoma, Angle-Closure / drug therapy, Humans, Lens Subluxation / surgery, Male, Vision Disorders / etiology

Background:
We encountered a rare patient with lens luxation in which the lens had become stuck on the optic disc. Findings obtained during vitreous surgery suggested that the luxated lens had become stuck on the optic disc via residual vitreous gel.
Case presentation:
An 88-year-old Japanese man experienced lens luxation into the inferior vitreous cavity while undergoing treatment for glaucoma in his left eye. Because no inflammation was present upon examination, we observed the patient without prescribing any additional medications except for the eye drop treatment for glaucoma. Two years later, the patient revisited our clinic after suddenly noticing a visual disturbance in his left eye. A fundus examination revealed that the luxated lens had become stuck on the optic disc and displayed no changes in relation to the patient's head position or eye movement. Subsequently, vitreous surgery was performed to remove the luxated lens. During the surgery, we observed an aggregation of vitreous gel between the luxated lens and the optic disc. The luxated lens was successfully mobilized by pushing with a vitreous cutter and then extracted through a corneoscleral incision using perfluorocarbon liquid. At 4 months after surgery, the patient's visual acuity had improved to 20/25.
Conclusions:
The findings of this study suggest that the luxated lens had become stuck on the optic disc via residual vitreous gel on the optic disc. The surgical procedure of extracting the luxated lens through a corneoscleral incision using perfluorocarbon liquid was found to be both safe and effective.
The application of metagenomic next-generation sequencing in pathogen diagnosis: a bibliometric analysis based on Web of Science
Authors: Sike He, Jingwen Wei, Jiaming Feng, Dan Liu, Neng Wang, Liyu Chen, Ying Xiong
Journal: Front Cell Infect Microbiol (2023)
Keywords: citespace, vosviewer, web of science, bibliometric analysis, metagenomic next-generation sequencing, pathogen diagnosis
MeSH terms: Bibliometrics, Communicable Diseases / diagnosis, Review, China, High-Throughput Nucleotide Sequencing, Humans, Metagenome

Background:
Infectious disease is a large burden on public health globally. Metagenomic next-generation sequencing (mNGS) has become popular as a new tool for pathogen diagnosis with numerous advantages compared to conventional methods. Recently, research on mNGS increases yearly. However, no bibliometric analysis has systematically presented the full spectrum of this research field. Therefore, we reviewed all the publications associated with this topic and performed this study to analyze the comprehensive status and future hotspots of mNGS for infectious disease diagnosis.
Methods:
The literature was searched in the Web of Science Core Collection and screened without year or language restrictions, and the characteristics of the studies were also identified. The outcomes included publication years, study types, journals, countries, authorship, institutions, frontiers, and hotspots with trends. Statistical analysis and visualization were conducted using VOSviewer (version 1.6.16) and CiteSpace (version 6.1. R3).
Results:
In total, 325 studies were included in the analysis after screening. Studies were published between 2009 and 2022 with a significantly increasing number from 1 to 118. Most of the studies were original articles and case reports. Frontiers in Cellular and Infection Microbiology and Clinical Infectious Disease were the most commonly cited and co-cited journals. Institutions and researchers from China contributed the most to this field, followed by those from the USA. The hotspots and frontiers of these studies are pneumonia, tuberculosis, and central nervous system infections.
Conclusion:
This study determined that mNGS is a hot topic in the diagnosis of infectious diseases with development trends and provides insights into researchers, institutions, hotspots and frontiers in mNGS, which can offer references to related researchers and future research.
Case Report: Minimal Neurological Deficit of Two Adult Patients With Weston-Hurst Syndrome Due to Early Craniectomy: Case Series and Review of Literature on Craniectomy
Authors: Anna Mira Loesch-Biffar, Andreas Junker, Jennifer Linn, Niklas Thon, Suzette Heck, Caroline Ottomeyer, Andreas Straube, Hans Walter Pfister
Journal: Front Neurol (2021)
Keywords: weston-hurst syndrome, acute hemorrhagic leukoencephalitis, autoimmun disease, decompressive craniectomy, outcome
MeSH terms: Case Reports

Objectives: We describe two new cases of acute hemorrhagic leucoencephalitis (AHLE), who survived with minimal sequelae due to early measures against increased intracranial pressure, particularly craniotomy. The recently published literature review on treatment and outcome of AHLE was further examined for the effect of craniotomy. Methods: We present two cases from our institution. The outcome of 44 cases from the literature was defined either as good (no deficit, minimal deficit/no daily help) or poor outcome (severe deficit/disabled, death). Patients with purely infratentorial lesions (n = 9) were excluded. Fisher's exact test was applied. Results: Two cases are presented: A 43-year-old woman with rapidly progressive aphasia and right hemiparesis due to a huge left frontal white matter lesion with rim contrast enhancement. Pathology was consistent with AHLE. The second case was a 56-year-old woman with rapidly progressive aphasia and right hemiparesis. Cranial MRI showed a huge left temporo-occipital white matter lesion with typical morphology for AHLE. Both patients received craniotomy within the first 24 h and consequent immunosuppressive-immunomodulatory treatment and survived with minimal deficits. Out of 35 supratentorial reported AHLE cases, seven patients received decompressive craniotomy. Comparing all supratentorial cases, patients who received craniotomy were more likely to have a good outcome (71 vs. 29%). Conclusion: Due to early control of the intracranial pressure, particularly due to early craniotomy; diagnosis per biopsy; and immediate start of immunosuppressive-immunomodulatory therapies (cortisone pulse, plasma exchanges), both patients survived with minimal sequelae. Craniotomy plays an important role and should be considered early on in patients with probable AHLE.
Streptococcus thoraltensis Bacteremia: First Described Case as a Fever of Unknown Origin in Human
Authors: Nikolaos Petridis, Athanasia Apsemidou, Georgios Kalopitas, Georgios Pilianidis, Iakovos Avramidis
Journal: Case Rep Infect Dis (2018)
MeSH terms: Case Reports

Streptococcus thoraltensis has mainly been reported to cause infections in animals. Its clinical significance as a human pathogen has not yet been fully elucidated and needs further investigation. We describe here a case of bacteremia attributed to S. thoraltensis in a 55-year-old female patient admitted to our department due to fever of unknown origin. To the best of our knowledge, this is the first reported case of S. thoraltensis bacteremia in a human and the first reported case of S. thoraltensis as a cause of fever of unknown origin in human.
An urologic face of chronic lymphocytic leukemia: sequential prostatic and penis localization
Authors: Giovanni D'Arena, Roberto Guariglia, Oreste Villani, Maria Carmen Martorelli, Giuseppe Pietrantuono, Giovanna Mansueto, Giuseppe Patitucci, Emilio Imbriani, Tommaso Masciandaro, Ludovica Borgia, Giulia Vita, Fiorella D'Auria, Teodora Statuto, Pellegrino Musto
Journal: Mediterr J Hematol Infect Dis (2013)
MeSH terms: Case Reports

We report a patient with chronic lymphocytic leukemia (CLL) in whom a leukemic involvement of prostate and penis occurred in the advanced phase of his disease. Obstructive urinary symptoms were indicative of prostatic CLL infiltration, followed by the occurrence of an ulcerative lesion on the glans. Histologic examination confirmed the neoplastic B-cell infiltration. Both localizations responded to conventional treatments. A review of the literature confirms that leukemic involvement of the genito-urinary system is uncommon in CLL patients. However, it should be considered in CLL patients with urologic symptoms and a long history of the disease.
Spontaneous Regression of Ovarian Carcinoma After Septic Peritonitis; A Unique Case Report
Authors: Thijs Roelofsen, Christina Wefers, Mark A J Gorris, Johannes C Textor, Leon F A G Massuger, I Jolanda M de Vries, Anne M van Altena
Journal: Front Oncol (2018)
Keywords: anti-tumor immune response, immune suppressive tumor environment, immunotherapy, regression of ovarian carcinoma, septic peritonitis
MeSH terms: Case Reports

Despite advances in therapy, ovarian cancer remains the most lethal gynecological malignancy and prognosis has not substantially improved over the past 3 decades. Immunotherapy is a promising new treatment option. However, the immunosuppressive cancer microenvironment must be overcome for immunotherapy to be successful. Here, we present a unique case of spontaneous regression of ovarian carcinoma after septic peritonitis. A 79-year-old woman was diagnosed with stage IIIc ovarian cancer. The omental cake biopsy was complicated by sepsis. Although the patient recovered, her physical condition did not allow further treatment for her ovarian cancer. After 6 months, spontaneous regression of the tumor was observed during surgery. Analysis of the immune infiltrate in the tissues showed a shift from a pro-tumorigenic to an anti-tumorigenic immune response after sepsis. Strong activation of the immune system during sepsis overruled the immunosuppressive tumor microenvironment and allowed for a potent anti-tumor immune response. More understanding of immunological responses in cases with cancer and septic peritonitis might be crucial to identify potential new targets for immunotherapy.
Urethral cavernous hemangioma in a female patient: a rare entity
Authors: Mustafa Suat Bolat, Kubilay Yüzüncü, Ekrem Akdeniz, Ayse Nurten Demirdoven
Journal: Pan Afr Med J (2015)
Keywords: urethral cavernous hemangioma, genital infection, urinary system
MeSH terms: Dyspareunia / etiology, Hemangioma, Cavernous / diagnosis, Hematuria / etiology, Urethral Neoplasms / diagnosis, Case Reports, Female, Hemangioma, Cavernous / pathology, Humans, Middle Aged, Urethral Neoplasms / pathology

Genitourinary hemangiomas are rare entities of the urinary system. We reported a female patient who suffered dyspareunia and intermitant hematuria that was proved as urethral cavernous hemangioma. Despite its benign nature, hemangiomas may recur due to incomplet excision.
A Novel Mutation in ERCC8 Gene Causing Cockayne Syndrome
Authors: Maryam Taghdiri, Hassan Dastsooz, Majid Fardaei, Sanaz Mohammadi, Mohammad Ali Farazi Fard, Mohammad Ali Faghihi
Journal: Front Pediatr (2017)
Keywords: cockayne syndrome, ercc8, intellectual disability, neurodevelopmental disorders, novel mutation, rare inherited disorders
MeSH terms: Case Reports

Cockayne syndrome (CS) is a rare autosomal recessive multisystem disorder characterized by impaired neurological and sensory functions, cachectic dwarfism, microcephaly, and photosensitivity. This syndrome shows a variable age of onset and rate of progression, and its phenotypic spectrum include a wide range of severity. Due to the progressive nature of this disorder, diagnosis can be more important when additional signs and symptoms appear gradually and become steadily worse over time. Therefore, mutation analysis of genes involved in CS pathogenesis can be helpful to confirm the suspected clinical diagnosis. Here, we report a novel mutation in ERCC8 gene in a 16-year-old boy who suffers from poor weight gain, short stature, microcephaly, intellectual disability, and photosensitivity. The patient was born to consanguineous family with no previous documented disease in his parents. To identify disease-causing mutation in the patient, whole exome sequencing utilizing next-generation sequencing on an Illumina HiSeq 2000 platform was performed. Results revealed a novel homozygote mutation in ERCC8 gene (NM_000082: exon 11, c.1122G>C) in our patient. Another gene (ERCC6), which is also involved in CS did not have any disease-causing mutations in the proband. The new identified mutation was then confirmed by Sanger sequencing in the proband, his parents, and extended family members, confirming co-segregation with the disease. In addition, different bioinformatics programs which included MutationTaster, I-Mutant v2.0, NNSplice, Combined Annotation Dependent Depletion, The PhastCons, Genomic Evolutationary Rate Profiling conservation score, and T-Coffee Multiple Sequence Alignment predicted the pathogenicity of the mutation. Our study identified a rare novel mutation in ERCC8 gene and help to provide accurate genetic counseling and prenatal diagnosis to minimize new affected individuals in this family.
Epstein-barr virus reactivation after infliximab in rheumatoid arthritis: a case report
Authors: Michele Colaci, Marco Sebastiani, Gilda Sandri, Marisa Meacci, Clodoveo Ferri
Journal: Case Rep Infect Dis (2011)
MeSH terms: Case Reports

TNF-alpha blockers represent one of the most important therapeutic strategies for rheumatoid arthritis, but their use has raised the question about their safety profile, particularly in respect to viral infections/reactivations. We describe the case of a patient who developed a symptomatic EBV reactivation 11 days after the first infusion of infliximab.
Acute respiratory distress syndrome caused by influenza B virus infection in a patient with diffuse large B-cell lymphoma
Authors: Silvio A Namendys-Silva, María O González-Herrera, Julia Texcocano-Becerra, Angel Herrera-Gómez
Journal: Case Rep Med (2011)
MeSH terms: Case Reports

Influenza B virus infections are less common than infections caused by influenza A virus in critically ill patients, but similar mortality rates have been observed for both influenza types. Pneumonia caused by influenza B virus is uncommon and has been reported in pediatric patients and previously healthy adults. Critically ill patients with pneumonia caused by influenza virus may develop acute respiratory distress syndrome. We describe the clinical course of a critically ill patient with diffuse large B-cell lymphoma nongerminal center B-cell phenotype who developed acute respiratory distress syndrome caused by influenza B virus infection. This paper emphasizes the need to suspect influenza B virus infection in critically ill immunocompromised patients with progressive deterioration of cardiopulmonary function despite treatment with antibiotics. Early initiation of neuraminidase inhibitor and the implementation of guidelines for management of severe sepsis and septic shock should be considered.
Clinical, evolution and therapeutical considerations upon a case of fibrodysplasia ossificans progressiva (FOP)
Authors: O Rogoveanu, R Traistaru, C T Streba, Z Stoica, R Popescu
Journal: J Med Life (2013)
Keywords: fibrodysplasia ossificans progressive, medical rehabilitation, osseous deformities, soft tissue calcifications
MeSH terms: Myositis Ossificans / diagnosis, Myositis Ossificans / therapy, Case Reports, Adult, Female, Humans, Magnetic Resonance Imaging, Myositis Ossificans / diagnostic imaging, Radiography

Fibrodysplasia ossificans progressiva (FOP) is an autosomal dominant genetic transmitted disease, with a rare incidence (1-2 cases/million persons) and it usually affects female patients. Its manifestations include acute pain episodes that tend to repeat, involving the soft tissue and the axial muscles with later appearance of ectopic bone tissue in ligaments, joints and tendons. In the great majority of times, the skeletal modifications are observed at birth but the first clinical symptoms occur at 2-4 years old. The clinical symptoms include pain and inflammation of the soft tissue, sometimes associated with fever and cutaneous erythema, joint symptoms--pain, stiffness most frequently concerning the scapular and pelvic girdle, bone malformations--short hallux, microdactilia, kyphoscoliosis, thorax malformations. The diagnosis is established based on the clinical symptoms and the imagistic investigations: CT, MRI - which indicate the joint modification and the ectopic bone tissue. Muscular biopsy is not indicated as it leads to new lesions in the already traumatized areas.