OpenMed/multicare-articles huggingface dataset:
Wegener's Granulomatosis presenting with an abscess in the parotid gland: a case report
Authors: Marcel Geyer, Gautham Kulamarva, Anne Davis
Journal: J Med Case Rep (2009)

Introduction:
Wegener's Granulomatosis is a vasculitis of uncertain aetiology. Affected patients usually present with disease of the respiratory and renal tracts. Classic symptoms and clinical findings, together with serology titres positive for anti-neutrophil cytolplasmic antibody against proteinase 3 confirm the diagnosis. Wegener's Granulomatosis can occasionally involve other organs, but solitary parotid gland disease is uncommon; patients generally also have systemic disease.
Case presentation:
We report a case of Wegener's Granulomatosis in a 69-year-old Caucasian female presenting initially with an isolated parotid abscess and only subsequently developing nasal, paranasal sinus and respiratory symptoms. We describe the clinical course, diagnostic difficulties, imaging and histopathology of this case.
Conclusion:
Major salivary gland infection is not an uncommon ENT disorder, but the clinician should be wary of the patient who fails to respond appropriately to adequate therapy. In such cases a differential diagnosis of Wegener's Granulomatosis should be considered, as early recognition and treatment of this potentially fatal disease is paramount.
Pseudo-rheumatic manifestations of limping: Camptodactyly-arthropathy-coxa vara-pericarditis syndrome: Single case report and review of the literature
Authors: Valerio Maniscalco, Camilla Pizzetti, Edoardo Marrani, Anna Perrone, Ilaria Maccora, Ilaria Pagnini, Rosangela Artuso, Gabriele Simonini, Maria Vincenza Mastrolia
Journal: Front Pediatr (2022)
Keywords: cacp syndrome, coxa vara, juvenile idiopathic arthritis, limping in children, temporo mandibular joint
MeSH terms: Case Reports

Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome is a rare genetic disease characterized by tetrad camptodactyly, noninflammatory arthropathy, coxa vara deformity, and pericardial effusion. Arthropathy typically affects large joints and presents with joint swelling in the absence of other signs of inflammation. We described the case of a girl affected by CACP syndrome caused by a novel compound heterozygous variant in proteoglycan 4 gene (c.2831_2832insT; c.3892C > T) and associated with temporomandibular involvement. The patient received treatment with intra-articular hyaluronic acid injections, which presented rapid but transient improvements of pain and range of motion. A literature review of previously reported CACP patients has been performed. Of the patients. 69.2% (101 out of 146) were Middle Eastern, and 65.7% (96) were consanguineous. The median age of onset was 24 months (interquartile range of 12-36 months), and median age of diagnosis was 96 months (interquartile range of 48-156 months). Arthropathy was always present, mainly involving hips (95.2%), knees (92.4%), wrists (87.7%), elbows (79.5%), and ankles (57.5%). Camptodactyly and pericardial effusion were described, respectively, in 97.3% (142) and 15.1% (22) of patients. The main radiological findings were coxa vara (95.2%), femoral changes (64.4%), intraosseus cysts (14.4%), and bone erosion (5%). Of the patients, 32.9% (48) had received a previous juvenile idiopathic arthritis diagnosis. CACP syndrome can be easily misdiagnosed with juvenile idiopathic arthritis. A prolonged lack of response to immunosuppressive therapy associated with typical clinical and radiological features should prompt consideration of this rare syndrome.
Successful therapy of ventricular rupture by percutaneous intrapericardial instillation of fibrin glue: a case report
Authors: Florian Willecke, Christoph Bode, Andreas Zirlik
Journal: Case Rep Vasc Med (2013)

Rupture of the ventricular myocardium is an often lethal complication after myocardial infarction. Due to the dramatic hemodynamics and the short time frame between ventricular rupture and surgical closure of the defect, additional therapeutic strategies are needed. Here we report the successful therapy of ventricular rupture by percutaneous intrapericardial instillation of fibrin glue in a 72-year-old male patient with postinfarct angina secondary to anterior myocardial infarction.
Lemierre's Syndrome: Recognising a Typical Presentation of a Rare Condition
Authors: James A Coultas, Neena Bodasing, Paul Horrocks, Anthony Cadwgan
Journal: Case Rep Infect Dis (2015)

Lemierre's syndrome is a rare complication following an acute oropharyngeal infection. The aetiological agent is typically anaerobic bacteria of the genus Fusobacterium. The syndrome is characterised by a primary oropharyngeal infection followed by metastatic spread and suppurative thrombophlebitis of the internal jugular vein. If left untreated, Lemierre's syndrome carries a mortality rate of over 90%. Whilst relatively common in the preantibiotic era, the number of cases of Lemierre's syndrome subsequently declined with the introduction of antibiotics. With the increase of antibiotic resistance and a greater reluctance to prescribe antibiotics for minor conditions such as tonsillitis, there are now concerns developing about the reemergence of the condition. This increasing prevalence in the face of an unfamiliarity of clinicians with the classical features of this "forgotten disease" may result in the misdiagnosis or delay in diagnosis of this potentially fatal illness. This case report illustrates the delay in diagnosis of probable Lemierre's syndrome in a 17-year-old female, its diagnosis, and successful treatment which included the use of anticoagulation therapy. Whilst there was a positive outcome, the case highlights the need for a suspicion of this rare condition when presented with distinctive signs and symptoms.
Severe anaphylactic reaction to cisatracurium during anesthesia with cross-reactivity to atracurium
Authors: Kotryna Linauskienė, Gintarė Grincevičienė, Laura Malinauskienė, Audra Blažienė, Anželika Chomičienė
Journal: Open Med (Wars) (2020)
MeSH terms: Case Reports

A case of a severe anaphylactic reaction during general anesthesia was reported. Despite the high suspicion for cefuroxime as a trigger of the anaphylactic reaction, cisatracurium emerged being the culprit drug. This case illustrates the importance of testing all drugs used during procedures/operations, trying to find a culprit of anaphylaxis.
Endoscopy- and Monitored Anesthesia Care-Assisted High-Resolution Impedance Manometry Improves Clinical Management
Authors: Kaci E Christian, John D Morris, Guofeng Xie
Journal: Case Rep Gastrointest Med (2018)
MeSH terms: Case Reports

Background:
High-resolution impedance manometry (HRiM) is the test of choice to diagnose esophageal motility disorders and is particularly useful for identifying achalasia subtypes, which often guide therapy. HRiM is typically performed without sedation in the office setting. However, a substantial number of patients fail this approach. We report our single-center experience on endoscopy-assisted HRiM under monitored anesthesia care (MAC) in adults to demonstrate the feasibility and effectiveness of this approach.
Methods:
Patients who had failed prior HRiM attempts received propofol under MAC. Patients then underwent an upper endoscopy, followed immediately by passage of a Diversateck HRiM motility catheter through the nares and under direct visualization into the stomach, often using the tip of the endoscope to guide the catheter. We then awakened the patients and asked them to perform 10 saline swallows.
Results:
We successfully completed HRiM studies in 14 consecutive patients. Six patients had achalasia; two had esophagogastric junction outflow obstruction; two had absent contractility; one had distal esophageal spasm; one had ineffective esophageal motility; and one had a normal study. The majority of these patients were treated successfully with targeted interventions, including per oral endoscopic myotomy, gastrostomy, botox injection, medical therapy, and dietary modifications.
Syphilis in pregnancy
Authors: Asrul Abdul Wahab, Umi Kalsom Ali, Marlyn Mohammad, Ezura Madiana Md Monoto, M M Rahman
Journal: Pak J Med Sci (2015)
Keywords: congenital syphilis, pregnancy, rapid plasma reagin, syphilis igg
MeSH terms: Case Reports

Syphilis in pregnancy remains an important medical condition due to its consequences. We present two cases of young pregnant women who were diagnosed syphilis during their antenatal visit. The first case was a 29-year-old Malay lady diagnosed with syphilis during the first trimester of pregnancy, while the second case was a 21-year-old Chinese lady diagnosed with syphilis during the third trimester of pregnancy. The diagnosis and management of the syphilis in pregnancy are discussed.
Venipuncture-induced complex regional pain syndrome: a case report and review of the literature
Authors: Foad Elahi, Chandan G Reddy
Journal: Case Rep Med (2014)

Venipuncture, the most frequently performed invasive medical procedure, is usually benign. Generally it produces only transitory mild discomfort. Venipuncture-induced neuropathic pain is hard to recognize at an early stage. Medical literature reviews show that there is not adequate medical knowledge about this important subject. The inciting incident in complex regional pain syndrome (CRPS) can often seem far too trivial to result in a condition with such severe pathophysiologic effects. The practicing physician has little information available to enable early recognition of the condition, initiation of multidisciplinary treatment modalities, and proper referral to pain specialists. We encountered a unique case of venipuncture-induced complex regional pain syndrome (CRPS). The patient is a 52-year-old school teacher with no significant past medical history, who presented initially to the Center of Pain Medicine with left upper extremity pain. The pain started while phlebotomy was performed in the patient's left antecubital area for routine blood check. The patient's pain did not improve with multiple medications, physical therapy, or several nerve blocks. The patient demonstrated all the signs and symptoms of chronic neuropathic pain of CRPS in the upper extremity with minimal response to the continuous pain management. We decided to proceed with cervical spinal cord nerve stimulation along with continuing other modalities. The patient responded to this combination. During the follow-up, we noticed that the patient's pain course was complicated by extension of the CRPS to her lower extremity. We will describe the course of treatment for the patient in this paper. In this paper we will discuss the electrical neuromodulation as an important modality in addition to the multidisciplinary pain management for a patient with venipuncture-induced chronic neuropathic pain.
Possible misdiagnosis of 46,XX testicular disorders of sex development in infertile males
Authors: Tong Chen, Linlin Tian, Xianlong Wang, Demin Fan, Gang Ma, Rong Tang, Xujun Xuan
Journal: Int J Med Sci (2020)
Keywords: 46,xx disorders of sex development, azoospermia factor, misdiagnosis, mosaicism, sex-determining region y
MeSH terms: 46, XX Disorders of Sex Development / diagnosis, Infertility, Male / genetics, Mosaicism, 46, XX Disorders of Sex Development / genetics, Adult, Azoospermia / genetics, Chromosomes, Human, Y / metabolism, Follicle Stimulating Hormone / metabolism, Humans, Luteinizing Hormone / metabolism, Male, Prolactin / metabolism, Retrospective Studies, Sex-Determining Region Y Protein / genetics, Testosterone / metabolism, Sex-Determining Region Y Protein, Testosterone, Prolactin, Luteinizing Hormone, Follicle Stimulating Hormone

Objectives: The 46,XX disorders of sex development (DSD) is a rare genetic cause of male infertility and possible misdiagnosis of this condition has never been reported. We aim to investigate clinical characteristics and laboratory results of infertile males with possibly misdiagnosed 46,XX DSD. Methods: Between January 2008 and December 2017, a retrospective case series study was performed involving sixteen 46,XX DSD males without azoospermia factor (AZF) deletion. Demographics, clinical features, laboratory results and assisted reproductive technology (ART) outcomes of these patients were depicted, and the underlying accurate diagnosis was also discussed. Results: The mean age was 30.06 ± 5.40 years old. Thirteen patients (81.25%) merely obtained secondary school education. Gynaecomastia occurred in one case, and cryptorchidism appeared in two cases. Testicular volumes were equal to 15 mL on two sides in one patient who had severe asthenozoospermia. Thirteen patients (81.25%) had bilateral atrophic testes which were below 5 mL. The majority of patients were observed with elevated levels of gonadotropic hormones and decreased testosterone values. Neither AZF region nor sex-determining region Y gene was absent among all patients. Twelve patients had normal ejaculatory function, whereas four were diagnosed with ejaculatory dysfunction. Eleven patients (68.75%) were diagnosed with azoospermia. Testicular sperm aspiration was performed in six subjects (37.50%). The pathological results showed that Leydig cell hyperplasia with spermatic failure was found in each case, and no sperm was found in testicular tissue. ART with donor sperm was conducted in 15 patients. Live birth was achieved in three cases through artificial insemination by donor and in one case using in-vitro fertilization by donor. Conclusions: Chromosomal analysis rarely yields 46,XX karyotype combined with no deletion of AZF in infertile males. Under this condition, molecular analysis should be conducted to avoid potential misdiagnosis and false interpretation of other findings.
A Patient with Splenic Artery Aneurysm Rupture and the Importance of Rapid Sonography in the ED
Authors: Masayuki Iyanaga, Susan Watts, Takeshi Kasai
Journal: Emerg Med Int (2010)
MeSH terms: Case Reports

We report a case of a splenic artery aneurysm rupture presenting with shock which required timely embolization therapy. This case demonstrates how the rapid use of bedside ultrasound by emergency department (ED) physicians can help identify the cause of shock and, therefore, initiate appropriate treatment quickly even if the cause is rare, as in this case.
Incidental Finding of Left Ventricular False Chamber: Diagnostic and Therapeutic Implications
Authors: Antonello Cuccaro, Riccardo Gorla, Domenico Lumia, Mattia Barbiero, Roberto De Ponti
Journal: Case Rep Med (2018)
MeSH terms: Case Reports

We present the case of a 75-year-old man with incidental finding of a left ventricular false chamber at echocardiography. A multimodality imaging approach including also transesophageal echocardiography and cardiac magnetic resonance imaging allowed to better characterize the lesion and identify it as a pseudoaneurysm. Surgery showed an infective aetiology, which is rare, due to the finding of a large abscess in the cavity.
Pregnant with metastatic neuroendocrine tumour of the ovary: what now?
Authors: B Pistilli, Cm Grana, N Fazio, A Cavaliere, Me Ferrari, L Bodei, Sm Baio, G Scambia, G Paganelli, Fa Peccatori
Journal: Ecancermedicalscience (2012)
MeSH terms: Case Reports

Neuroendocrine tumours (NET) are a heterogeneous group of neoplasms commonly occurring in the gastrointestinal tract or lungs but can occur in other regions. Primary ovarian NET account for 5% of all NET and 0.1% of all ovarian malignancies. In metastatic disease, the therapeutic goal is to extend survival and to improve quality of life. As these tumours express somatostatin receptors, somatostatin analogues are frequently used to control symptoms. Here we present a case of a pregnant woman with an ovarian NET with liver metastases and carcinoid syndrome who was treated with the somatostatin analogue, Octreotide LAR. We also summarize reported data of the use of somatostatin analogues during pregnancy.
Early Response after Catheter Ablation of the Epicardial Substrate in a Patient with Brugada Syndrome Can Be Predicted by High Precordial Leads
Authors: Yae Min Park, Mi Sook Cha, Hanul Choi, Woong Chol Kang, Seung Hwan Han, In Suck Choi, Eak Kyun Shin, Young-Hoon Kim
Journal: Case Rep Cardiol (2018)
MeSH terms: Case Reports

A 52-year-old male with Brugada syndrome presented with repeated and appropriate shock from an implantable cardioverter defibrillator (ICD). Catheter ablation for substrate elimination targeting low-voltage, complex, and fractionated electrocardiograms and late potentials in the epicardial right ventricular outflow tract was successfully performed. Brugada phenotype in the right precordial leads from the third intercostal space disappeared in the early stage after catheter ablation and that from the standard fourth intercostal space disappeared later. He remained free from ventricular fibrillation over the next fourteen months. We suggest that this novel ablation strategy is effective in Brugada syndrome patients with ICD, and early response after catheter ablation can be predicted by high precordial leads.
Post retraction citations in context: a case study
Authors: Judit Bar-Ilan, Gali Halevi
Journal: Scientometrics (2017)
Keywords: negative citations, neutral citation, positive citations, post retraction citations, retracted articles

This study examines the nature of citations to articles that were retracted in 2014. Out of 987 retracted articles found in ScienceDirect, an Elsevier full text database, we selected all articles that received more than 10 citations between January 2015 and March 2016. Since the retraction year was known for only about 83% of the retracted articles, we chose to concentrate on recent citations, that for certain appeared after the cited paper was retracted. Overall, we analyzed 238 citing documents and identified the context of each citation as positive, negative or neutral. Our results show that the vast majority of citations to retracted articles are positive despite of the clear retraction notice on the publisher's platform and regardless of the reason for retraction. Positive citations can be also seen to articles that were retracted due to ethical misconduct, data fabrication and false reports. In light of these results, we listed some recommendations for publishers that could potentially minimize the referral to retracted studies as valid.
Emotion Regulation Therapy: A Mechanism-Targeted Treatment for Disorders of Distress
Authors: Megan E Renna, Jean M Quintero, David M Fresco, Douglas S Mennin
Journal: Front Psychol (2017)
Keywords: depression, emotion regulation, generalized anxiety disorder, mindfulness, treatment

"Distress disorders," which include generalized anxiety disorder and major depression are often highly comorbid with each other and appear to be characterized by common temperamental features that reflect heightened sensitivity to underlying motivational systems related to threat/safety and reward/loss. Further, individuals with distress disorders tend to utilize self-referential processes (e.g., worry, rumination, self-criticism) in a maladaptive attempt to respond to motivationally relevant distress, often resulting in suboptimal contextual learning. Despite the success of cognitive behavioral therapies for emotional disorders, a sizable subgroup of patients with distress disorders fail to evidence adequate treatment response. Emotion Regulation Therapy (ERT) is a theoretically derived, evidence based, treatment that integrates principles (e.g., skills training, exposure) from traditional and contemporary therapies with findings from basic and translational affective science to offer a framework for improving intervention by focusing on the motivational responses and corresponding regulatory characteristics of individuals with high levels of chronic distress. Open and randomized controlled trials have demonstrated preliminary support for the utility of ERT as reflected by strong effect sizes comparable to and exceeding established intervention approaches. In addition, pilot findings support the role of underlying proposed mechanisms in this efficacious response. This article presents the functional model associated with ERT and describes the proposed mechanisms of the treatment. Additionally, a clinical case is presented, allowing the reader to gain a greater applied understanding of the different components of the ERT model and treatment.
Fahr's disease presenting with dementia at onset: a case report and literature review
Authors: Rocco Salvatore Calabrò, Letteria Spadaro, Angela Marra, Placido Bramanti
Journal: Behav Neurol (2014)
MeSH terms: Basal Ganglia Diseases / complications, Brain / diagnostic imaging, Calcinosis / complications, Dementia / etiology, Neurodegenerative Diseases / complications, Case Reports, Review, Aged, Basal Ganglia Diseases / diagnostic imaging, Calcinosis / diagnostic imaging, Dementia / diagnostic imaging, Humans, Male, Neurodegenerative Diseases / diagnostic imaging, Radiography

Fahr's disease (FD) is characterized by sporadic or familiar idiopathic calcification of the basal ganglia, dentate nuclei of the cerebellum, and centrum semiovale, mainly presenting with movement disorder, dementia, and behavioral abnormalities. We described a rare case of Fahr's disease presenting at onset only with behavioral and neuropsychological alterations, whose diagnosis was supposed only after a brain CT, which showed extensive bilateral calcifications in the dentate nuclei of the cerebellum and basal ganglia. Since the onset of Fahr's disease may be a dysexecutive syndrome with behavioral abnormalities, the clinical and radiological features are really important to do the appropriate diagnosis.
Concomitant existence of left atrial ball thrombus and mural thrombus of left appendage in patient with rheumatic mitral stenosis: a case report
Authors: Ismail Oughebbi, Said Benlamkaddem, Reda Bzikha, Mustapha Harandou
Journal: Pan Afr Med J (2022)
Keywords: mitral stenosis, ball thrombus, case report, left atriam
MeSH terms: Atrial Fibrillation / complications, Heart Diseases / diagnosis, Heart Diseases / etiology, Heart Valve Diseases / complications, Mitral Valve Stenosis / complications, Mitral Valve Stenosis / surgery, Thrombosis / etiology, Case Reports, Heart Atria / surgery, Humans

Valvular heart disease, and in particular, rheumatic mitral stenosis is frequently associated with intra-cardiac thrombus. Moreover, almost all types of thrombus can be founded in the left atrium whereas the ball shaped thrombus remains very rare. The following case report describes a successful surgical management of an unusual case with a concomitant left atrial free-floating ball thrombus and mural one in a patient who has rheumatic mitral stenosis with atrial fibrillation. However, this patient did not present any cerebral or peripheral embolic events. Left atrial ball thrombus is relatively a rare case. Once the diagnosis was made, the surgical removal should be done immediately to avoid embolic complications and deterioration of hemodynamics.