OpenMed/multicare-articles huggingface dataset:
Hepatitis G virus associated aplastic anemia: a recent case from Pakistan
Authors: Shahida Amjad Riaz Shah, Muhammad Idrees, Abrar Hussain
Journal: Virol J (2011)
MeSH terms: Anemia, Aplastic / diagnosis, Flaviviridae Infections / complications, GB virus C / isolation & purification, Hepatitis, Viral, Human / complications, Case Reports, Anemia, Aplastic / pathology, Anemia, Aplastic / virology, Biopsy, Bone Marrow / pathology, Child, Cytological Techniques, Female, Flaviviridae Infections / pathology, Flaviviridae Infections / virology, GB virus C / genetics, Hepatitis, Viral, Human / pathology, Humans, Pakistan, RNA, Viral / genetics, RNA, Viral / isolation & purification, Reverse Transcriptase Polymerase Chain Reaction / methods, RNA, Viral

Background:
Aplastic anemia (AA) is a serious and rare disorder characterized by a hypocellular bone marrow. Hepatitis associated aplastic anemia (HAAA) is a variant of aplastic anemia in which aplastic anemia follows an acute attack of hepatitis. Several reports have noted an association between HGV and hepatitis-associated aplastic anemia besides other hepatitis causing viruses.
Case presentation:
A female girl of age 11 year with a history of loose motion for one month, vomiting for last 15 days and poor oral intake for last few days is reported here. The physical examination presents fever, pallor whereas bleeding, hepatomegaly, Splenomegaly and bruising were absent, abdominal ultrasonography confirmed the absence of hepatomegaly, Splenomegaly and lymphodenopathy. The laboratory investigation parameters were: haemoglobin 6.2 g/L, total leucocytes count 1.51, neutrophils 0.47%, absolute reticulocyte count 0.5%, Monocytes 0.16%, red cell count 3.2 mil/uL, Picked cell volume (PCV) 30.13%, Mean Corpuscular Volume (MCV) 78 fL, Mean Corpuscular Hemoglobin (MCH) 26.3 pg. The liver enzymes were alanine aminotransferease (ALT) 98 IU/L, aspartate aminotransferase (AST) 114 IU/L. Serologic and molecular tests for hepatitis A, B, C, D, E, TTV, B19 were negative, whereas HGV RNA PCR test was found positive for hepatitis G virus. The bone marrow aspirate and trephine biopsy examination revealed hypo- cellularity, erythropoiesis, myelopoiesis and megakaryopoiesis.
Conclusion:
HAAA is an uncommon but severe condition, which may occur following idiopathic cases of acute hepatitis. Our finding suggests the involvement of HGV in the development of aplastic anemia. In patients presenting with pancytopenia after an episode of acute hepatitis, the definitive diagnosis should be considered and confirmed by RT-PCR and if possible by bone marrow biopsy.
Acute Lower Limb Ischemia in COVID-19 Patient with Delayed Presentation
Authors: Sangam Shah, Rukesh Yadav, Rajan Chamlagain, Yagya Raj Adhikari, Sanjit Kumar Sah, Bipin Kandel, Subash Basnet, Sutap Yadav
Journal: Case Rep Cardiol (2021)
MeSH terms: Case Reports

Thromboembolism is a common complication of SARS-CoV-2, which generally involves venous thromboembolism, although there have been reported cases of arterial thrombosis affecting cerebral, coronary, and visceral arteries, as well as arteries in the extremities. We discuss a case of a 45-year-old diabetic man with COVID-19 who developed late-onset acute lower limb ischemia.
Warthy-Basaloid Squamous Cell Carcinoma of Penile - Case Report
Authors: Natalia Domian, Grzegorz Młynarczyk, Irena Kasacka
Journal: Front Oncol (2021)
Keywords: adhesion molecules, basaloid carcinoma, human papillomavirus, penile squamous cell carcinoma, warty carcinoma
MeSH terms: Case Reports

Objective:
The aim of the study was to present a case of penile squamous cell carcinoma and immunohistochemical identification and evaluation of E-cadherin and β-catenin expression.
Methods:
We are presenting a 70-year old man with a variant of penile squamous cell carcinoma with mixed warty and basaloid features. After diagnosis, the patient underwent partial penectomy. Samples taken from the material after surgery were subjected to basic histological staining and immunohistochemical identification of E-cadherin and β-catenin. A Real-time PCR study was conducted to investigate the expression of E-cadherin and β-catenin.
Results:
Routine histopathological examinations revealed the characteristic features of warty-basaloid squamous cell carcinoma. In the case studied, a positive immunohistochemical reaction was observed for E-cadherin and β-catenin. QRT-PCR analysis showed a statistically significant decrease in E-cadherin expression in tumor samples compared to healthy tissue. In contrast, expression of the gene encoding β-catenin was slightly higher in tumor samples compared to normal tissue.
Conclusions:
The reduced level of the complex of adhesive elements, E-cadherin-β-catenin, disturbs cell differentiation, promotes a more invasive phenotype-stromal infiltration and the formation of distant metastases. In the described case of the penile tumor, a decrease in E-cadherin expression was noted, which could be related to the occurrence of neoplastic infiltration of the spongy body space. In summary, E-cadherin and β-catenin expression and the immunoreactivity of these proteins are expressed at different levels in tumor cells and in penile interstitial cells. Regulation of expression during various physiological and pathophysiological processes indicates a potentially important role of E-cadherin and β-catenin in cell proliferation and adhesion.
Refractory rheumatic disorder: atypical postpregnancy osteoporosis
Authors: Cindy Mourgues, Sandrine Malochet-Guinamand, Martin Soubrier
Journal: Case Rep Rheumatol (2015)

This is a case report on a young patient with severe osteoporosis that was initially revealed when she presented with polyarthralgia during her second pregnancy. Postpartum, the pain increased and her X-ray did not show any abnormalities. A bone scintigraphy was performed. It indicated an inflammatory rheumatic disorder. Six months after partum, an investigation of right coxalgia revealed a spontaneous basicervical fracture. Given the persistent polyarthralgia, the patient underwent a new scintigraphy, which revealed areas of what looked to be old rib and L1 fractures. A subsequent full body magnetic resonance imaging (MRI) scan revealed signal abnormalities that could indicate multiple lower limb bone fractures. Despite exhaustive biological, radiological, and histological testing, no secondary cause for the osteoporosis was found. The patient was started on teriparatide. We finally concluded that, despite the atypical presentation, the patient was suffering from postpregnancy osteoporosis. It is possible that the frequency of occurrence of this still poorly understood disease is underestimated.
Staged osteotome sinus floor elevation for progressive site development and immediate implant placement in severely resorbed alveolar bone: a case report
Authors: Saad Al-Almaie
Journal: Case Rep Dent (2013)

This case report discusses osteotome sinus floor elevation (OSFE) and immediate placement in 2 stages in severely resorbed alveolar bone height in which multiple implant placement is not otherwise feasible due to a lack of initial stability. The first implant placed using OSFE without bone grafting prepares the adjacent resorbed sites for further implant placement in the sinus areas, which allows for better initial stability and early functional loading. This process avoids the conventional extensive lateral approach for sinus lifting and bone grafting procedures even in extremely resorbed alveolar bone.
Squamous cell carcinoma arising from inverted schneiderian papilloma: a case report with oral involvement
Authors: Alexandre Simões Garcia, Diego Maurício Bravo-Calderón, Mariana Pisinato Ferreira, Denise Tostes Oliveira
Journal: Case Rep Otolaryngol (2014)

Inverted Schneiderian papilloma is an uncommon benign tumor that presents tendency to recur and propensity to be associated with malignancy in approximately 10% of the cases. Some of these lesions are isolated in the maxillary sinus, and predominantly affect white males with mean age of 50 years. We report a case of squamous cell carcinoma arising from inverted Schneiderian papilloma in the maxillary sinus extending to the mouth. The patient was submitted to extraction of a maxillary molar tooth four months before the exacerbation of the symptoms of nasal airway obstruction and facial enlargement. Computed tomography scan revealed a sinonasal mass causing opacification of the right maxillary sinus with destruction of the lateral nasal wall and maxillary sinus floor. The patient was referred to an oncology center for treatment and died from tumor progression one year after the cancer was diagnosed. The intention of this report is to alert dentists to include the inverted Schneiderian papilloma, either associated with squamous cell carcinoma, or not, in the differential diagnosis of maxillary sinus tumors with aggressive behavior, which may extend to the oral cavity or involve roots of teeth.
Crash Landing of Thyroid Storm: A Case Report and Review of the Role of Extra-Corporeal Systems
Authors: Shir Lynn Lim, Kangjie Wang, Pak Ling Lui, Kollengode Ramanathan, Samantha Peiling Yang
Journal: Front Endocrinol (Lausanne) (2021)
Keywords: continuous renal replacement therapy, extra-corporeal membrane oxygenation, multi-organ failure, out-of-hospital cardiac arrest, therapeutic plasma exchange, thyroid storm
MeSH terms: Extracorporeal Membrane Oxygenation / methods, Shock, Cardiogenic / therapy, Thyroid Crisis / complications, Case Reports, Review, Adult, Humans, Male, Prognosis, Shock, Cardiogenic / etiology, Shock, Cardiogenic / pathology

Thyroid storm is a rare but life-threatening endocrinological emergency with significant mortality ranging from 10-30% with multi-organ involvement and failure. In view of the rarity of this condition and efficacy of established first line medical treatment, use of extra-corporeal treatments are uncommon, not well-studied, and its available evidence exists only from case reports and case series. We describe a 28-year-old man who presented with an out-of-hospital cardiac arrest secondary to thyroid storm. Despite conventional first-line pharmacotherapy, he developed cardiogenic shock and circulatory collapse with intravenous esmolol infusion, as well as multi-organ failure. He required therapeutic plasma exchange, concurrent renal replacement therapy, and veno-arterial extra-corporeal membrane oxygenation, one of the few reported cases in the literature. While there was clinical stabilization and improvement in tri-iodothyronine levels on three extra-corporeal systems, he suffered irreversible hypoxic-ischemic brain injury. We reviewed the use of early therapeutic plasma exchange and extra-corporeal membrane oxygenation, as well as the development of other novel extra-corporeal modalities when conventional pharmacotherapy is unsuccessful or contraindicated. This case also highlights the complexities in the management of thyroid storm, calling for caution with beta-blockade use in thyrocardiac disease, with close monitoring and prompt organ support.
Pulmonary Thromboembolism Complicating Amebic Liver Abscess: First Reported Case in the United States-Case Report and Literature Review
Authors: Devon McKenzie, Michael Gale, Sunny Patel, Grazyna Kaluta
Journal: Case Rep Infect Dis (2015)

Even in the absence of Amebic colitis, Amebic liver abscess (ALA) is the most common extraintestinal complication of Entamoeba histolytica infection. In the USA, it is most prevalent in middle aged immigrant males from endemic countries such as Africa, Mexico, and India. One of the complications of ALA is inferior vena cava (IVC) thrombosis, which is believed to result from the mechanical compression of the IVC and the consequent thrombogenic nidus elicited from the resultant inflammatory response. There are very few reported cases and even fewer in which the thrombus became a harbinger to pulmonary thromboembolism. We present the case of a 43-year-old male from West Africa who presented with the chief complaint of right upper quadrant abdominal pain for one week associated with persistent nonproductive cough. He had a positive serum Entamoeba histolytica antibody with CT scan findings of a hepatic abscess with thrombosis of the hepatic vein and inferior vena cava and numerous bilateral pulmonary emboli. This amebic liver abscess was successfully treated with metronidazole and paromomycin, whereas the pulmonary thromboembolism was managed with medical anticoagulation. Based on current knowledge, this is the first reported case in the USA.
Comprehensive Clinicopathologic and Molecular Analysis of Mast Cell Leukemia With Associated Hematologic Neoplasm: A Report and In-Depth Study of 5 Cases
Authors: Philippa Li, Giulia Biancon, Timil Patel, Zenggang Pan, Shalin Kothari, Stephanie Halene, Thomas Prebet, Mina L Xu
Journal: Front Oncol (2021)
Keywords: acute myeloid leukemia, associated hematologic neoplasm, mast cell leukemia, systemic mastocytosis (sm), whole-exome sequencing
MeSH terms: Case Reports

Mast cell leukemia with associated hematologic neoplasm (MCL-AHN) is a rare and highly aggressive entity that remains understudied due to the paucity of cases. We present a case of a 45-year-old man who was concurrently diagnosed with mast cell leukemia and acute myeloid leukemia. We identified four additional patients who had MCL-AHN in our institution and performed whole-exome sequencing of all available tumors. Our series revealed a novel and identical NR2F6 variant shared among two of the patients. This case series and sequencing results demonstrate the importance of fully characterizing rare tumors that are resistant to treatment.
Persistent Genital Arousal Disorder: Two Case Studies and Exploration of a Novel Treatment Modality
Authors: Meghan Scantlebury, Romeo Lucas
Journal: Womens Health Rep (New Rochelle) (2023)
Keywords: pelvic pain, persistent genital arousal disorder, sexual dysfunction
MeSH terms: Case Reports

Persistent genital arousal disorder (PGAD) is characterized by persistent unwanted feelings of sexual arousal that can be debilitating. Despite first being defined >20 years ago, the precise etiology and treatment of this disorder remain elusive. Mechanical disruption of nerves, neurotransmitter changes, and cyst formation have all been considered as etiologies involved with the development of PGAD. With limited and ineffective treatment modalities, many women live with their symptoms untreated or undertreated. To broaden the literature, we present two cases of PGAD and present a novel treatment modality of the disorder with the use of a pessary. Although there was subjective success in dampening the symptoms, they were not completely resolved. These findings open the door for the potential of similar treatments in the future.
An Asian case of combined 17α-hydroxylase/17,20-lyase deficiency due to homozygous p.R96Q mutation: A case report and review of the literature
Authors: Qian Liao, Rufei Shen, Mingyu Liao, Chenxi Ran, Ling Zhou, Yuling Zhang, Guiliang Peng, Zheng Sun, Hongting Zheng, Min Long
Journal: Front Endocrinol (Lausanne) (2022)
Keywords: 17α-hydroxylase/17,20-lyase deficiency, 46,xy disorder of sex development, congenital adrenal hyperplasia (cah), inguinal hernia, pr96q mutation
MeSH terms: Adrenal Hyperplasia, Congenital / complications, Adrenal Hyperplasia, Congenital / diagnosis, Adrenal Hyperplasia, Congenital / genetics, Metabolic Diseases / complications, Review, Case Reports, Research Support, Non-U.S. Gov't, Adult, Female, Homozygote, Humans, Male, Mixed Function Oxygenases / genetics, Mutation, Steroid 17-alpha-Hydroxylase / genetics, Young Adult, Steroid 17-alpha-Hydroxylase, Mixed Function Oxygenases

Background:
Combined 17α-hydroxylase/17,20-lyase deficiency (17-OHD) is a very rare form of congenital adrenal hyperplasia (CAH) caused by mutations in the CYP17A1 gene. Almost 100 different mutations of the CYP17A1 gene have been reported, including p.R96Q mutation, but no case of p.R96Q mutation has been described in Asian populations.
Case presentation:
We describe a 22-year-old female patient of 46,XY karyotype, who presented with pseudohermaphrodism, primary amenorrhea, underdeveloped secondary sexual characteristics, delayed epiphyseal healing, hypertension, and hypokalemia. The diagnosis of 17-OHD was reached by measurement of steroid hormones and abdominal CT scan and confirmed by genetic sequencing, which revealed a homozygous p.R96Q missense mutation in the CYP17A1 gene. The patient received treatment with dexamethasone and estradiol, and 4 months of follow-up showed that both blood pressure and potassium were well controlled.
Conclusions:
This is the first Asian case of CAH caused by a homozygous p.R96Q missense mutation in the CYP17A1 gene. Herein, we highlight the role of inguinal hernia in the early diagnosis of female 17-OHD and the necessity of removing the ectopic testis.
Adverse events associated with yoga: a systematic review of published case reports and case series
Authors: Holger Cramer, Carol Krucoff, Gustav Dobos
Journal: PLoS One (2013)
MeSH terms: Eye / physiopathology, Musculoskeletal System / physiopathology, Nervous System / physiopathology, Yoga, Review, Systematic Review, Adult, Databases, Bibliographic, Female, Glaucoma / physiopathology, Humans, Male, Medical Records / statistics & numerical data, Middle Aged, Treatment Failure

While yoga is gaining increased popularity in North America and Europe, its safety has been questioned in the lay press. The aim of this systematic review was to assess published case reports and case series on adverse events associated with yoga. Medline/Pubmed, Scopus, CAMBase, IndMed and the Cases Database were screened through February 2013; and 35 case reports and 2 case series reporting a total of 76 cases were included. Ten cases had medical preconditions, mainly glaucoma and osteopenia. Pranayama, hatha yoga, and Bikram yoga were the most common yoga practices; headstand, shoulder stand, lotus position, and forceful breathing were the most common yoga postures and breathing techniques cited. Twenty-seven adverse events (35.5%) affected the musculoskeletal system; 14 (18.4%) the nervous system; and 9 (11.8%) the eyes. Fifteen cases (19.7%) reached full recovery; 9 cases (11.3%) partial recovery; 1 case (1.3%) no recovery; and 1 case (1.3%) died. As any other physical or mental practice, yoga should be practiced carefully under the guidance of a qualified instructor. Beginners should avoid extreme practices such as headstand, lotus position and forceful breathing. Individuals with medical preconditions should work with their physician and yoga teacher to appropriately adapt postures; patients with glaucoma should avoid inversions and patients with compromised bone should avoid forceful yoga practices.
Mucormycosis of mandible with unfavorable outcome
Authors: Nitin Prakash Oswal, Pushkar Kiran Gadre, Prachee Sathe, Kiran Shrikrishna Gadre
Journal: Case Rep Dent (2012)
MeSH terms: Case Reports

Mucormycosis is a fulminant fungal infection that occurs most often in diabetic and immunocompromised individuals. Our patient, with uncontrolled diabetes mellitus and multiple systemic disorders, developed postextraction mucormycosis of mandible, an extremely rare complication. An initial clinical and radiographic diagnosis of mandibular osteomyelitis was made and the lesion was treated medically and surgically with curettage and saucerisation. The specimen was sent for histopathological evaluation, which showed necrotic area containing broad aseptate fungal hyphae with right angle branching consistent with mucormycosis. The patient succumbed to multipleorgan failure secondary to septicemia. The disease is usually fatal with a poor survival rate; there is still paucity of literature on the definitive management of this disease involving the mandible. This paper emphasizes the need for correction of underlying immunodeficiency and early diagnosis with aggressive multimodality treatment approach to offer the best chance of survival.
Colon perforation by foreign body insertion for sexual gratification: a case report
Authors: Alphonce Nsabi Simbila, Ahmed Suphian, Novath Julius Ngowi, Ramadhani Juma Mfinanga, Said Kilindimo, Hendry Robert Sawe
Journal: Pan Afr Med J (2021)
Keywords: rectal foreign body, auto-eroticism, case report, colon perforation, sexual gratification
MeSH terms: Colonic Diseases, Foreign Bodies / complications, Foreign Bodies / surgery, Intestinal Perforation / diagnosis, Intestinal Perforation / etiology, Intestinal Perforation / surgery, Case Reports, Adult, Colon, Sigmoid / surgery, Humans, Male, Orgasm

Occurrence of retained rectal foreign bodies with bowel perforation resulting from auto-eroticism is rare among males in Africa. Embarrassment attached to this condition may delay or derail acquisition of information and management. A 30-year-old male presented with abdominal pain and constipation for 3 days. Abdominal X-rays revealed free air-stripes under both hemidiaphragms and in the peripherals, a 25cm x 5.9cm lucent foreign body on the left side with proximal tapering. There was no evidence of intestinal obstruction. This was consistent with bowel perforation secondary to foreign body introduction. Exploratory laparotomy was performed, a plastic bottle of 250mls was removed from the colon. Transverse repair of a 10cm laceration extending from the rectum to the sigmoid was done and a colostomy placed. A high index of suspicion, a systematic approach and a lower threshold for imaging studies were key to successful management and favorable outcomes of this patient.
Manual Testicular Detorsion under Propofol Sedation
Authors: Martyn Harvey, Giles Chanwai, Grant Cave
Journal: Case Rep Med (2009)
MeSH terms: Case Reports

Acute spermatic cord torsion is a urologic emergency requiring accurate diagnosis and timely intervention to effect testicular salvage. We report a case of adolescent testicular torsion successfully reduced following manual detorsion under sedation at the Emergency Department. Scrotal exploration and bilateral orchidopexy were subsequently performed as a semielective procedure.
Post-anastomotic venous stenosis after Optiflow deployment: An unexpected outcome
Authors: Ziad Al Adas, George Haddad, Bhavin C Patel, Lalathaksha Kumbar, Baha Al-Abid, Praveen Balraj, Loay S Kabbani
Journal: SAGE Open Med Case Rep (2019)
Keywords: arteriovenous fistula, optiflow device, dialysis, vascular graft stenosis
MeSH terms: Case Reports

Arteriovenous fistula failure represents a major cause of hospitalization and a significant economic burden for end-stage renal disease patients on hemodialysis. The Optiflow (Bioconnect Systems Inc., Ambler, PA) is a new device developed to improve arteriovenous fistula outcomes and decrease failure rates by reducing the risk of stenosis and improving maturation rates. This case report describes a 50-year-old male with hypertensive nephropathy on dialysis who had multiple arteriovenous fistula failures in the past. He was scheduled to undergo brachiocephalic fistula construction using the Optiflow device. After 8 months of use, the new fistula developed a peri-anastomotic venous stenosis, just distal to the Optiflow device. To our knowledge, this is the first time such a complication has been reported.
An Acute Leukaemia Masquerading as Immune Thrombocytopaenic Purpura (ITP)? A Case Report
Authors: J A Olaniyi
Journal: Clin Med Case Rep (2009)
Keywords: m4 subtype, acute myeloid leukaemia, bleeding, immune thrombocytopaenic purpura, pregnancy
MeSH terms: Case Reports

This is a case report of a 35 year old female with diagnosed Immune Thrombocytopaenic Purpura (ITP) that was strangely followed by acute myeloid leukaemia at 10 months post diagnosis of ITP. She was managed as ITP using prednisolone 45 mg daily for 10 months with good response. She also synchronously carried a pregnancy to term and safe delivery. Shortly after delivery, she represented with gingival bleeding and peripheral film review and subsequent bone marrow cytology was in keeping with AML-M4 subtype. She died shortly after diagnosis without being able to receive chemotherapy.