OpenMed/multicare-articles huggingface dataset:
Epididymal Adenomatoid Tumor: A Very Rare Paratesticular Tumor of Childhood
Authors: Ioannis Patoulias, Christos Kaselas, Dimitrios Patoulias, Constantine Theocharides, Maria Kalogirou, Konstantinos Farmakis, Thomas Feidantsis
Journal: Case Rep Med (2016)

Adenomatoid tumor is an uncommon benign mesothelial neoplasm, usually localized in the epididymis. It is the most common paratesticular tumor of middle-aged patients (average age of clinical presentation: 36 years). However, these tumors in pediatric and pubertal patients are extremely rare. Due to their rarity, we present a case of adenomatoid tumor of the tail of the epididymis in a 16-year-old patient. After systematic research of the current literature, we did not find another case report of epididymal adenomatoid tumor in a male patient aged 16 years old or less. This notice and our concern, as well, about the patient's surveillance protocol during the postoperative period were the motive for this case study.
Case Report: Successful Avatrombopag Treatment for Two Cases of Anti-PD-1 Antibody-Induced Acquired Amegakaryocytic Thrombocytopenia
Authors: Xiaofang Tu, Ali Xue, Suye Wu, Mengmeng Jin, Pu Zhao, Hao Zhang
Journal: Front Pharmacol (2022)
Keywords: acquired amegakaryocytic thrombocytopenia, anti-pd-1 antibody, avatrombopag, immune-related adverse events, thrombopoietin receptor agonists
MeSH terms: Case Reports

Background: Anti-PD-1/PD-L1 immunotherapy has achieved impressive responses in multiple types of malignancies in recent years. However, immune-related adverse events (irAEs) occur and limit their continuous clinical use. Among these irAEs, acquired amegakaryocytic thrombocytopenia (AAT) is rare but often clinically serious, life-threatening and refractory to multiple treatment approaches. Case summary: We reported for the first time the successful treatment of avatrombopag in two cases of anti-PD1 antibody-induced AAT (in particular, one case had progressed to aplastic anemia), which was refractory or intolerant to glucocorticoids, ciclosporin, intravenous immunoglobulin (IVIG), recombinant human thrombopoietin (rh-TPO) and even TPO receptor agonist (TPO-RA) eltrombopag. To date, the two cases manifested as normal platelet counts and are independent of transfusion. Conclusion: Anti-PD1 antibody-induced AAT occurs with low frequency but is often serious and difficult to manage, for which this study proposed vatrombopag as a potential curative and safe approach.
Fatal Hemoptysis due to Chronic Cavitary Pulmonary Aspergillosis Complicated by Nontuberculous Mycobacterial Tuberculosis
Authors: Ioannis Kokkonouzis, Ioannis Athanasopoulos, Nikolaos Doulgerakis, Grigorios Tsonis, Ioannis Lampaditis, Nikolaos Saridis, Vasilios Skoufaras
Journal: Case Rep Infect Dis (2011)
MeSH terms: Case Reports

A 51-year-old man, with a history of severe COPD and bilateral pneumothorax, who was under treatment for pulmonary tuberculosis due to mycobacterium avium, was admitted due to high-grade fever, weight loss, cough, and production of purulent sputum, for almost one month without any special improvement despite adequate antibiotics treatment in outpatient setting. A CT scan revealed multiple consolidations, fibrosis, scaring, and cavitary lesions in both upper lobes with newly shadows which were fungus balls inside them. Aspergillus flavius was isolated in three sputum samples, a diagnosis of chronic cavitary pulmonary aspergillosis was made, and treatment with intravenous amphotericin B was started. An initially clinical improvement was noted, and a first episode of minor hemoptysis was treated with conservative measures. Unfortunately a second major episode of hemoptysis occurred and he died almost immediately. Aspergilloma is defined as the presence of a fungus ball inside a preexisting pulmonary cavity or dilated airway and is one of the clinical conditions associated with the clinical spectrum of pulmonary colonization. Tuberculosis is the most common underling disease. Hemoptysis is the most common symptom. Antifungal antibiotics, surgical interventions, bronchial arteries embolization, and intracavity infusion of antibiotics have been proposed without always adequate sufficiency.
Dynamic Change of VOR and Otolith Function in Intratympanic Gentamicin Treatment for Ménière's Disease: Case Report and Review of the Literature
Authors: L E Walther, R Huelse, K Blättner, M B Bloching, A Blödow
Journal: Case Rep Otolaryngol (2013)

Intratympanic gentamicin treatment (IGT) is an evidence-based therapeutic option for recurrent vertigo attacks in Ménière's disease (MD). Today, in MD it is possible to monitor changes of vestibular receptor function, induced by IGT, with objective test methods such as the video head impulse test (vHIT) and cervical and ocular vestibular evoked myogenic potentials (cVEMP, oVEMP) in a dynamic, time-and frequency-dependent manner. We report on a 65-year-old female patient with recurrent vertigo attacks in a right-sided MD, where receptor function was followed up before and up to 4 weeks after IGT (time dynamic). Quantitative changes of vestibular function (frequency dynamic) were detected with bithermal calorics and vHIT, with air-conducted sound (ACS) cVEMP and bone-conducted vibration (BCV) oVEMP at 500 Hz. The horizontal vestibuloocular reflex (hVOR) gain in vHIT decreased successively until the 4th week with the appearance of catch-up covert and catch-up overt refixation saccades, and side asymmetry increased in caloric testing. Saccular function was extinguished within 4 weeks, whereas utricular function was diminished after 4 weeks. Monitoring vestibular receptor function with objective test methods provides a quantitative insight into the dynamic activity of vestibular function and is therefore applicable in order to adjust IGT regimen at different therapeutic stages.
Multi-Omics Interdisciplinary Research Integration to Accelerate Dementia Biomarker Development (MIRIADE)
Authors: Ekaterina Mavrina, Leighann Kimble, Katharina Waury, Dea Gogishvili, Nerea Gómez de San José, Shreyasee Das, Salomé Coppens, Bárbara Fernandes Gomes, Sára Mravinacová, Anna Lidia Wojdała, Katharina Bolsewig, Sherif Bayoumy, Felicia Burtscher, Pablo Mohaupt, Eline Willemse, Charlotte Teunissen, MIRIADE consortium
Journal: Front Neurol (2022)
Keywords: assay development, biomarkers, cerebrospinal fluid, dementia, immunoassays, implementation, mass spectrometry

Proteomics studies have shown differential expression of numerous proteins in dementias but have rarely led to novel biomarker tests for clinical use. The Marie Curie MIRIADE project is designed to experimentally evaluate development strategies to accelerate the validation and ultimate implementation of novel biomarkers in clinical practice, using proteomics-based biomarker development for main dementias as experimental case studies. We address several knowledge gaps that have been identified in the field. First, there is the technology-translation gap of different technologies for the discovery (e.g., mass spectrometry) and the large-scale validation (e.g., immunoassays) of biomarkers. In addition, there is a limited understanding of conformational states of biomarker proteins in different matrices, which affect the selection of reagents for assay development. In this review, we aim to understand the decisions taken in the initial steps of biomarker development, which is done via an interim narrative update of the work of each ESR subproject. The results describe the decision process to shortlist biomarkers from a proteomics to develop immunoassays or mass spectrometry assays for Alzheimer's disease, Lewy body dementia, and frontotemporal dementia. In addition, we explain the approach to prepare the market implementation of novel biomarkers and assays. Moreover, we describe the development of computational protein state and interaction prediction models to support biomarker development, such as the prediction of epitopes. Lastly, we reflect upon activities involved in the biomarker development process to deduce a best-practice roadmap for biomarker development.
Non-traumatic Acute Epidural Hematoma in Multiple Sclerosis Treated With Fingolimod
Authors: Ryoko Fukai, Keita Takahashi, Hiroyuki Abe, Yuichi Higashiyama, Hiroshi Doi, Hideyuki Takeuchi, Fumiaki Tanaka
Journal: Front Neurol (2019)
Keywords: epidural hematoma, fingolimod, multiple sclerosis, sphingosine-1-phosphate receptor, vascular disruption
MeSH terms: Case Reports

Fingolimod acts as a functional antagonist of the sphingosine-1-phosphate receptor and is widely used for relapsing-remitting multiple sclerosis (MS). Here we report the first case of non-traumatic acute epidural hematoma in a relapsing-remitting MS patient treated with fingolimod. Fingolimod might increase the risk of hemorrhage by enhancing vasospasm and causing vascular disruption. Switching fingolimod to other disease-modifying drugs, including dimethyl fumarate, should be considered when non-traumatic hemorrhage is observed in MS patients.
Popliteal pterygium syndrome: a rare entity
Authors: Muhammad Qasim, Mahmood Shaukat
Journal: APSP J Case Rep (2012)
Keywords: autosomal dominant disorder, familial, popliteal pterygium syndrome
MeSH terms: Case Reports

The popliteal pterygium syndrome is a congenital malformation that includes orofacial, musculoskeletal and genitourinary anomalies. It is a rare autosomal dominant disorder. We report one family with popliteal pterygium syndrome affecting father and his two daughters, who underwent surgical corrections for multiple congenital malformations.
PAX5-KIAA1549L: a novel fusion gene in a case of pediatric B-cell precursor acute lymphoblastic leukemia
Authors: Stefanie Anderl, Margit König, Andishe Attarbaschi, Sabine Strehl
Journal: Mol Cytogenet (2015)
Keywords: b-cell precursor acute lymphoblastic leukemia, kiaa1549l, pax5 fusion
MeSH terms: Case Reports

Background:
In B-cell precursor acute lymphoblastic leukemia (BCP-ALL) PAX5, a transcription factor pivotal for B-cell commitment and maintenance, is frequently affected by genetic alterations. In 2-3 % of the cases PAX5 rearrangements result in the expression of oncogenic fusion genes. The encoded chimeric proteins consist of the N-terminal PAX5 DNA-binding paired domain, which is fused to the C-terminal domains of a remarkable heterogeneous group of partner proteins.
Results:
Employing fluorescence in situ hybridization and molecular methods PAX5-KIAA1549L was identified as novel fusion gene in a case of pediatric BCP-ALL.
Conclusion:
Our report underlines the high diversity of PAX5 fusion partners in BCP-ALL and we describe the second involvement of KIAA1549L in a genetic rearrangement in acute leukemia.
Neurofeedback Training for Cognitive and Motor Function Rehabilitation in Chronic Stroke: Two Case Reports
Authors: Wenya Nan, Ana Paula Barbosa Dias, Agostinho C Rosa
Journal: Front Neurol (2019)
Keywords: alpha, chronic stroke, cognition, neurofeedback, rehabilitation
MeSH terms: Case Reports

Stroke is a debilitating neurological condition which usually results in the abnormal electrical brain activity and the impairment of sensation, motor, or cognition functions. In this context, neurofeedback training, i.e., a non-invasive and relatively low cost technique that contributes to neuroplasticity and behavioral performance, might be promising for stroke rehabilitation. We intended to explore neurofeedback training on a 63-year-old male patient and a 77-year-old female patient with chronic stroke. Both of them had suffered from an ischemic stroke for rather long period (more than 3 years) and could not gain further improvement by traditional therapy. The neurofeedback training was designed to enhance alpha activity by 15 sessions distributed over 2 months, for the purpose of overall cognitive improvement and hopefully also motor function improvement for the female patient. We found that the two patients showed alpha enhancement during NFT compared to eyes open baseline within most sessions. Furthermore, both patients reduced their anxiety and depression level. The male patient showed an evolution in speech pattern in terms of naming, sentences completion and verbal fluency, while the female patient improved functionality of the march. These results suggested that alpha neurofeedback training could provide a spectrum of improvements, providing new hope for chronic stroke patients who could not gain further improvements through traditional therapies.
Peripheral Nerve Stimulation for the Treatment of Phantom Limb Pain: A Case Series
Authors: Robert Pagan-Rosado, Brandon J Smith, Fantley C Smither, Matthew J Pingree, Ryan S D'Souza
Journal: Case Rep Anesthesiol (2023)
MeSH terms: Case Reports

This case series aims to highlight the efficacy of peripheral nerve stimulation (PNS) in the treatment of phantom limb pain, as well as provide an alternative method for the treatment of this pain syndrome. In this report, we describe three amputee patients with severe phantom limb pain who obtained substantial analgesia and improvement in physical functionality after implantation of a temporary PNS device. Future studies should assess predictors of successful response or poor response to PNS therapy, such as mental health, environmental stressors, coping skills, and procedural factors. These factors may facilitate an individualized approach for each patient to ensure appropriate candidacy for PNS and better prognosis. Considering that patients in our cohort did not achieve long-lasting benefit after removal of temporary PNS, future research should assess if patients with phantom limb pain would benefit from permanent PNS, rather than temporary PNS.
Transcatheter Aortic Valve Implantation in a Nonagenarian with Aortic Aneurysm: Futility or Utility?
Authors: Evelyn Fennelly, Marcus Lee, Mark Da Costa, Sherif Sultan, Faisal Sharif, Darren Mylotte
Journal: Case Rep Cardiol (2018)
MeSH terms: Case Reports

Transcatheter aortic valve implantation (TAVI) has emerged as the standard of care for older patients with symptomatic severe aortic stenosis (AS) at high or excessive operative risk. There remain patients that are of such considerable risk that even TAVI can be futile. Such patients present ethical conundrums for institutional heart teams. Herein we present a case of a 90-year-old female patient with symptomatic severe AS and significant comorbidities including diffuse peripheral vascular disease and a large ascending aortic aneurysm. Would TAVI be utile or futile in this patient?
Extreme Elevation of Alkaline Phosphatase in a Pregnancy Complicated by Gestational Diabetes and Infant with Neonatal Alloimmune Thrombocytopenia
Authors: Svjetlana Lozo, Amir Atabeygi, Michael Healey
Journal: Case Rep Obstet Gynecol (2016)

There have been few case reports of isolated elevation of alkaline phosphatase beyond the normal physiologic amount with subsequent return to baseline after delivery. Here we present a similar case of extreme elevation of alkaline phosphatase in a pregnancy complicated by gestational diabetes and subsequently by neonatal alloimmune thrombocytopenia (NAIT).
An unusual case of bilateral renal enlargement due to primary renal lymphoma
Authors: S C Dash, K Purohit, S K Mohanty, A K Dinda
Journal: Indian J Nephrol (2011)
Keywords: extranodal lymphoma, normal renal function, symmetrical renal enlargement
MeSH terms: Case Reports

Primary renal lymphoma is an uncommon variant of extranodal non-Hodgkin's lymphoma. Manifestations are usually nonspecific hematuria, fever, flank pain, and renal insufficiency. Pathological data are scanty; few reports indicate it has a very poor prognosis. We describe a child with bilateral symmetrically palpable kidneys, low-grade pyrexia, and arthralgia. Clinically, diagnosis was missed partly due to the fact that bilateral large renal tumors commonly produce asymmetric renal swelling, renal dysfunction, and hematuria which were absent in this case and partly due to rarity of the condition. However, radiological investigations combined with renal histology helped in establishing diagnosis in the present case.
An Atypical Case of Shiga Toxin Producing- Escherichia Coli Hemolytic and Uremic Syndrome (STEC-HUS) in a Lung Transplant Recipient
Authors: Louis Manière, Camille Domenger, Boubou Camara, Diane Giovannini, Paolo Malvezzi, Lionel Rostaing
Journal: Case Rep Transplant (2019)
MeSH terms: Case Reports

We herein describe the first case of thrombotic microangiopathy (TMA) which was related to Shiga toxin producing-Escherichia Coli Hemolytic and Uremic Syndrome (STEC-HUS) after lung transplantation. His maintenance immunosuppression relied on tacrolimus plus mycophenolic acid. TMA was treated with plasma exchanges (PE) (fresh frozen plasma substitution). After five days of PE, platelets count and lactate dehydrogenase level normalized, whereas hemoglobin continued to gradually decrease and no improvement in kidney function was observed. After seven PE sessions, all TMA biological signs resolved. However, kidney function did not improve, and the patient still required chronic dialysis.
Recording the Centric Relation in an Edentulous Patient Using the Existing Complete Denture Mounted with Gothic Arch Tracer
Authors: Xu Wei, X F Meng, Lang Guo, Xiaoping Luo, Wei Han
Journal: Case Rep Dent (2021)
MeSH terms: Case Reports

An 80-year-old man sought treatment at our hospital. He was dissatisfied with his old complete denture due to its poor stability and retention. The old complete denture had been used for about 20 years. The prolonged use of an unsuitable complete denture led the patient to be accustomed to unilateral mastication (UM). Due to the patient long-term habitual mandibular deviation, using the physiological technique to get the centric relation (CR) achieved an incorrect horizontal maxillomandibular record. This clinical report presents a technique using the existing complete denture mounted with a Gothic arch tracer to determine the CR. This technique is an inexpensive, simple, and reliable method that allows fabricating the final impression and obtaining the maxillomandibular relationship record (MMRR) in one step.
Management of OSAS: The ELIBA® Device Can Help the Patient?
Authors: Eleonora Ortu, Davide Pietropaoli, Alessandra Mummolo, Iapnor, Mario Giannoni, Annalisa Monaco
Journal: Case Rep Dent (2020)
MeSH terms: Case Reports

Obstructive sleep apnea syndrome (OSAS) is one of the most challenging diseases to treat in medicine. Here, the authors describe a case of OSAS treated with a lingual elevator of Balercia (ELIBA®). The patient, a forty-five-year-old Caucasian male, had a chief complaint of numerous episodes of nocturnal apnea. After several visits with specialists, a polysomnographic examination was performed, in which the patient's apnea hypopnea index (AHI) was 30.4, and a lingual elevator was prescribed. The lingual elevator helped to keep the patient's tongue in the correct position and prevented the tongue from reverting back to the soft tissue spaces in the mouth. After six months of treatment with the lingual elevator and dietary adjustments, the patient's AHI decreased to 11.6. This simple yet customizable approach is a comfortable and easy option for patients to reduce night apnea episodes.
Small bowel cocoon: a distinct disease with a new developmental etiology
Authors: Ibrahim E Bassiouny, Tariq O Abbas
Journal: Case Rep Surg (2011)
MeSH terms: Case Reports

We have treated two patients with small bowel (abdominal) cocoon who presented with acute and partial small bowel obstruction associated with an abdominal mass. Neither had a history of previous surgery, peritonitis, or prolonged drug therapy. The distinct features of this disease are illustrated. A developmental etiology and a new nomenclature for this disease are proposed, along with a review of the literature.
Remission of Thymoma on Steroid Therapy in a Patient With Atypical Thymoma-Associated Multiorgan Autoimmunity: A Case Report and Literature Review
Authors: Ewa Wrona, Sylwia Dębska-Szmich, Marta Pastuszka, Marcin Braun, Rafał Czyżykowski, Piotr Potemski
Journal: Front Immunol (2021)
Keywords: mucocutaneous lesions, paraneoplastic autoimmune multiorgan syndrome (pams), remission on steroids, thymoma, thymoma-associated multiorgan autoimmunity (tama)
MeSH terms: Autoimmunity / immunology, Thymoma / immunology, Thymus Neoplasms / immunology, Case Reports, Research Support, Non-U.S. Gov't, Review, Adrenal Cortex Hormones / therapeutic use, Aged, Female, Humans, Myasthenia Gravis / complications, Paraneoplastic Syndromes / diagnosis, Paraneoplastic Syndromes / drug therapy, Paraneoplastic Syndromes / immunology, Remission Induction, Thymoma / complications, Thymoma / drug therapy, Thymus Neoplasms / complications, Thymus Neoplasms / drug therapy, Adrenal Cortex Hormones

In up to 34% of cases, thymoma, itself a rare neoplasm, is accompanied by autoimmune disorders, two of which are thymoma-associated multiorgan autoimmunity (TAMA) and paraneoplastic autoimmune multiorgan syndrome (PAMS). Unfortunately, differential diagnosis between these two entities can be challenging since no strict PAMS definition exists and PAMS can overlap with a subgroup of TAMA patients with skin lesions as leading presentation. We present a case of a 68-year-old woman with a diagnosis of thymoma accompanied by myasthenia gravis, hypothyroidism and GvHD-like mucocutaneous lesions that initially could account to both TAMA and PAMS diagnosis. However, following the exclusion of humoral autoimmunity against components of epithelial cells junction, TAMA was finally established. Interestingly, the introduction of corticosteroid therapy for TAMA symptom management resulted in unexpected partial remission of thymoma with no impact on mucocutaneous lesions. Our case study is an example of two extremely rare phenomena accompanying thymomas: unprecedented TAMA presentation with GvHD-like mucositis, which as we postulate should be placed in the spectrum of TAMA, and tumor remission on steroids.
A Case Report of Leukocytosis During Modified Electroconvulsive Therapy of Paranoid Personality Disorder
Authors: Xingyu Mu, Jiao Xu, Peilin Lin, Ya Luo, Yuan Zhu, Yi Shi, Shangtao Chen, Zengxiang Wu, Shuangqing Li
Journal: Front Psychiatry (2022)
Keywords: case report, leukocytosis, modified electroconvulsive therapy (mect), monocytes, neutrophils, paranoid personality disorder
MeSH terms: Case Reports

Introduction:
Modified electroconvulsive therapy (MECT) is a viable therapeutic option for patients with mood disorders and schizophrenia. We found that there is a relationship between MECT and leukocytosis. To the best of our knowledge, this is the first case of this problem. There are no relevant guidelines recommending the risk of leukocytosis caused by MECT, nor the method to reduce the risk. We hope to share this case to provide a reference for the prevention and treatment of similar patients with leukocytosis during or after MECT and remind psychiatrists to pay attention to this risk of leukocytosis before making the decision of MECT while knowing how to deal with it.
Case presentation:
We describe a case of a 24-year-old woman diagnosed with Paranoid personality disorder (PPD) whose symptoms began at 19 years old. Her main clinical manifestations are feeling targeted, cheated, tracked, misunderstood, and repeating action. Since antipsychotic treatment was ineffective, we considered MECT. After MECT, the patient's body temperature increased, and leukocytosis was found. After excluding infection and other possibilities, we added 1,000 ml physiological saline to the patient through the vein. The white blood cell (WBC) count returned to normal in a short time.
Conclusion:
Before MECT, it is necessary to screen blood cytology. During and after MECT, we should be alert to leukocytosis that may be related to MECT and deal with it correctly in time.