OpenMed/multicare-articles huggingface dataset:
Case Report: Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis With Acute Renal Failure and Pulmonary Hemorrhage May Occur After COVID-19 Vaccination
Authors: Chien-Chou Chen, Hsin-Yang Chen, Chun-Chi Lu, Shih-Hua Lin
Journal: Front Med (Lausanne) (2021)
Keywords: covid-19, anti-neutrophil cytoplasmic antibody (anca), pulmonary renal syndrome, vaccination, vasculitis
MeSH terms: Case Reports

The rare and severe adverse effects associated with coronavirus disease of 2019 (COVID-19) vaccination have been under-appreciated, resulting in many instances of inappropriate management. We describe the case of an elderly woman who developed anti-neutrophil cytoplasmic antibody-associated vasculitis with pulmonary renal syndrome approximately 3 weeks after the first dose of COVID-19 mRNA vaccination (Moderna). Her nasopharyngeal polymerase chain reaction test for the COVID-19 RNA virus was negative. Gross hematuria, heavy proteinuria, acute renal failure (serum creatinine up to 6.5 mg/dL), and hemoptysis coupled with a marked increase in serum anti-myeloperoxidase-O antibody were observed. Renal biopsy showed severe vasculitis with pauci-immune crescent glomerulonephritis. The pulmonary hemorrhage was resolved and renal function improved following combined plasma exchange and the administration of systemic steroids and anti-CD20 therapy. The early examination of urinalysis and renal function may be crucial for identifying glomerulonephritis and acute renal failure in susceptible patients after COVID-19 vaccination.
ATRA Induced Reactive Hemophagocytosis: a Case Report
Authors: Monica Sharma, Jasmita Dass, Seema Tyagi
Journal: Mediterr J Hematol Infect Dis (2011)
MeSH terms: Case Reports

All trans-retinoic acid (ATRA) is a targeted therapy, used in Acute Promyelcytic leukemia (APL) and causes the abnormal promyelocytes to differentiate in to mature leucocytes, however their clearance in vivo is not known. ATRA has been found to be associated with hemophagocytosis, but sometimes one may find phagocytosis of differentiated cells by histiocytes without the overt manifestations of hemophagocytic syndrome. We report a case of APL showing differentiated cells being phagocytosed by marrow histiocytes while patient was getting ATRA therapy.
A case of sudden onset of thyroid storm just before cesarean section manifesting congestive heart failure and pulmonary edema
Authors: Yuki Sugiyama, Ryusuke Tanaka, Yuki Yoshiyama, Takashi Ichino, Norimasa Hishinuma, Sari Shimizu, Noriko Imai, Kunihiro Mitsuzawa, Mikito Kawamata
Journal: JA Clin Rep (2017)
Keywords: mgso4, mitral regurgitation, pulmonary edema, ritodrine, thyroid storm

Background:
Since acute respiratory failure (ARF) is a life-threatening complication, particularly in the gestational period, differential diagnosis and rapid treatment are required. Among the various causes of sudden onset of ARF, thyroid storm is a rare cause in a parturient complicated with well-controlled hyperthyroidism. In this case report, we describe a parturient with hyperthyroidism in whom a thyroid storm manifesting congestive heart failure and pulmonary edema developed just before an emergency ceasarean section, even though hyperthyroidism was well-controlled with antithyroid drugs.
Case presentation:
A 36-year-old pregnant woman was diagnosed as having clinical chorioamnionitis, and an emergency cesarean section was performed at 25 weeks of pregnancy. She had a complication of hyperthyroidism accompanied by mild mitral regurgitation, and she had been treated with methimazole. She was treated with ritodrine and MgSO4 for the threat of premature delivery. At the preoperative consultation, her percutaneous oxygen saturation (SpO2) was 98% on room air. When she was admitted to the operating room, her heart rate and blood pressure were 130 beats/min and 196/78 mmHg, respectively. SpO2 was 88% on room air without any symptoms; however, just after starting oxygen administration via a facemask, she complained of severe respiratory distress and became agitated. Partial pressure of arterial oxygen was 108 mmHg with an inspiratory oxygen fraction of 1.0. Chest radiography revealed pulmonary congestion, and transesophageal echocardiography revealed normal right ventricular function without an embolus and severe mitral regurgitation with preserved left ventricular function. Contrast-enhanced computed tomography after the operation revealed no pulmonary embolus but revealed a pulmonary effusion, and free triiodothyronine level was increased at the onset of dyspnea. Therefore, we diagnosed the causes of sudden onset of dyspnea as pulmonary edema and congestive heart failure induced by a thyroid storm.
Conclusion:
Sudden onset of a thyroid storm just before a cesarean section occurred in a patient with several risk factors of thyroid storm and pulmonary edema, including pregnancy, treatment with tocolytic agents, and infection. The involvement of these multiple factors was considered to be the cause of the sudden onset of the thyroid storm and the cause of rapidly progressive pulmonary edema.
Infectious Trigger for Autoimmune Encephalitis: A Case Report and Literature Review
Authors: Najmus Sahar, Alexander Michael Nurre, Ryan Q Simon
Journal: Case Rep Infect Dis (2019)
MeSH terms: Case Reports

Herpes simplex virus 1 infection is a common cause of encephalitis (HSVE) in the United States. Post-HSVE development of N-methyl-D-aspartate receptor (NMDAR) antibodies resulting in autoimmune encephalitis is a rare complication, primarily affecting children and young adults. Anti-NMDAR develops 1-4 weeks after HSVE, manifesting as choreoathetosis and/or orofacial dyskinesia in children and psychiatric symptoms in young adults. We describe a case of a 61-year-old male who presented with agitation, behavioral changes, and confusion eight months after being treated for HSVE. Extensive investigation was unrevealing except for cerebrospinal fluid lymphocytic pleocytosis, a positive anti-NMDAR Ab titer 1 : 64, and imaging changes consistent with postviral encephalitis suggestive of HSV-induced anti-NMDAR encephalitis. Aggressive therapy resulted in limited success and persistent neurologic deficits. The unique features of this case are the old age of the patient and preceding HSVE which triggered this autoimmune process. Physicians should consider anti-NMDAR encephalitis in the differentials for relapsing patients after HSVE.
Liquid biopsy can cure early colorectal cancer recurrence - Case Report
Authors: Alexander Baraniskin, Hideo A Baba, Dirk Theegarten, Thomas Mika, Roland Schroers, Susanne Klein-Scory
Journal: Front Oncol (2023)
Keywords: pet-ct, ras, colorectal cancer, ddpcr, follow-up, liquid biopsy, mutation detection, tumor promotor p53 tp53
MeSH terms: Case Reports

In the context of colorectal cancer (CRC), circulating tumor DNA (ctDNA) is frequently used to monitor the minimal residual disease (MRD). ctDNA has become an excellent biomarker to predict which patients with CRC are likely to relapse due to the persistence of micrometastases. MRD diagnosis via analysis of ctDNA may allow much earlier detection of relapse compared with conventional diagnosis during follow-up. It should lead to an increased rate of curative-intended complete resection of an asymptomatic relapse. Besides, ctDNA can provide crucial information on whether and how intensively adjuvant or additive therapy should be administered. In the present case, analysis of ctDNA gave us a crucial hint to the use of more intensive diagnostics (MRI and Positron emission tomography-computed tomography PET-CT) which led to earlier detection of CRC relapse. Metastasis detected early are more likely to be completely resectable with curative intent.
Cauda equina syndrome secondary to leptomeningeal metastases from recurrent primary peritoneal carcinoma
Authors: Zhen Ni Zhou, Chelsea Canon, Cathleen Matrai, Eloise Chapman-Davis
Journal: Ecancermedicalscience (2018)
Keywords: cauda equina syndrome, leptomeningeal metastasis, primary peritoneal carcinoma
MeSH terms: Case Reports

The patient is a 42-year-old woman with metastatic primary peritoneal carcinoma and known brain metastases, who subsequently developed cauda equina syndrome after presenting with ataxia, lower extremity weakness, and bowel and bladder incontinence secondary to leptomeningeal metastasis after treatment with neoadjuvant chemotherapy, surgical debulking, and adjuvant chemotherapy. Metastases to the central nervous system (CNS) and leptomeninges are rare events in epithelial ovarian and primary peritoneal carcinomas as these tumours do not have a predilection for the CNS. Cauda equina syndrome is often characterised by gait disturbances, bowel and bladder dysfunction, saddle anaesthesia, and lower extremity muscle weakness. In patients with known metastatic gynaecologic carcinomas presenting with nonspecific neurologic symptoms, cauda equina syndrome should remain high in the differential diagnosis.
COVID-19 in the United States as affective frame
Authors: John Protevi
Journal: Front Psychol (2022)
Keywords: covid-19, deleuze, foucault, affect, biopower, critical phenomenology, enaction, racism

In this paper I attempt to contribute to the developing field of "political philosophy of mind." To render concrete the notion of "affective frame," a social situation which pre-selects for salience and valence of environmental factors relative to a subject's life, I conduct a case study of a deleterious socially instituted affective frame, which, during the early days of the COVID-19 pandemic in the United States, produced individuated circumstances that came crashing down on "essential workers" who were forced into a double bind. We saw here an untenable and ultimately fatal situation that forced a choice between, on the one hand, increasing the risk of their failing to provide financial support for their family if they quit their job or reduced their hours, and on the other, increasing their risk of contracting the virus by continuing to work. The case study will thus be itself an affective frame that will bring to the fore for its readers a nexus of harmful social practices of contemporary American society. Form is reinforced by content here, as this particular affective frame brings forth a further emphasis on affect when we focus on workers simultaneously socialized into roles as breadwinners and as members of the caring professions. For those people, quitting work becomes even more difficult as they come to affirm their self-identity of being providers of affective labor for those in their care at work and of being the affective anchor of family life at home, the one who financially helps keep a roof over the heads of their loved ones as well as being the emotional backbone of the family. Hence the affective frame of "essential workers in Covid times" renders salient and affirmatively valenced their affectively laden self-image as caring helpers of those in need, at home and at work.
Primary bone marrow diffuse large B-cell lymphoma accompanying cold agglutinin disease: A case report with review of the literature
Authors: Tomoko Yamashita, Mitsuaki Ishida, Hiroko Moro, Hirofumi Yumoto, Sachiko Uchibayashi, Miyuki Yoshii, Ryota Nakanishi, Hiroko Okuno, Takashi Yoshida, Takafumi Okuno, Keiko Hodohara, Hidetoshi Okabe
Journal: Oncol Lett (2014)
Keywords: cold agglutinin disease, diffuse large b cell lymphoma, primary bone marrow lymphoma

Cold agglutinin disease (CAD) is a well-recognized complication of lymphoproliferative disorders. It has been previously recognized that cases of primary CAD frequently exhibit underlying malignant lymphoma in the bone marrow. Lymphoplasmacytic lymphoma is the most common subtype of malignant lymphoma; however, diffuse large B-cell lymphoma (DLBCL) has also been documented, albeit extremely rare. The current report presents a case of primary bone marrow DLBCL accompanying CAD. A 76-year-old male presented with fever and fatigue. Laboratory tests revealed anemia and elevated bilirubin and cold agglutinins with a titer of 8,192 at 4°C. Bone marrow biopsy demonstrated DLBCL and systemic surveillance failed to detect tumorous lesions or lymphadenopathy. Following R-THP-COP therapy, cold agglutinins titer was markedly decreased (by <4); however, malignant lymphoma relapsed and cold agglutinin levels increased again (4,096). This is the second documented case of primary bone marrow DLBCL accompanying CAD. Previously, malignant lymphoma exclusively involving the bone marrow, namely primary bone marrow lymphoma (PBML), has been recognized as a rare and aggressive subtype. The analyses of the present study revealed that the incidence of hemolytic anemia in primary bone marrow DLBCL may be high compared with conventional DLBCL. Therefore, additional analyses are required to clarify the clinicopathological features of PBML.
Not Everything Is Cordless Today-Case Report of Acute Intestinal Obstruction in a Neonate Due to Cord Clamping
Authors: Daniel Keese, Anne-Kathrin Schwalbach, Andrea Schmedding, Udo Rolle
Journal: Front Pediatr (2022)
Keywords: cord clamping, hernia to the cord, intestinal obstruction, newborn, omphalocele
MeSH terms: Review

We report a case of a 2-day-old neonate with bilious vomiting and abdominal distension. A small bowel obstruction with ileal perforation due to a misplaced clamping of the umbilical cord was apparent before laparotomy. This complication was a sequala after clamping the cord too close to the abdominal wall in a case where there was a hernia into the cord with intestinal content. A herniation of abdominal contents due to an omphalocele minor or a hernia must be taken into consideration during the inspection of the umbilical cord before clamping.
Three-Dimensional Visualization With Virtual Reality Facilitates Complex Live Donor Renal Transplant
Authors: Dennis Sonnier, W Peter Sawyer, John Seal, Colin Curtis, Jack McGee, Alec Slayden, Korak Sarkar
Journal: Ochsner J (2022)
Keywords: kidney transplantation, living donor, radiology, virtual reality
MeSH terms: Case Reports

Background: Living donor renal transplant involves highly technical operations in both a healthy donor and a recipient with end-stage kidney disease. Contrast-enhanced computed tomography angiography (CTA) is used to assess critical donor anatomy, but its interpretation becomes increasingly difficult as renal anatomy becomes more complex. Case Report: A related donor was denied because of prohibitive anatomy seen on the pretransplant evaluation CTA. As the donor was highly motivated to donate, CTA DICOM images were segmented to create a 3-dimensional (3D) model that could be evaluated in an immersive and stereoscopic virtual reality (VR) environment. The donor's anatomy was found to be acceptable, and he was approved. Conclusion: In live donor nephrectomy candidates, 3D reconstruction and VR visualization can be used to facilitate appreciation of complex anatomy.
Tailoring the delivery of cancer diagnosis to adolescent and young adult patients displaying strong emotions: An observational study of two cases
Authors: Live Korsvold, Hanne Cathrine Lie, Anneli Viktoria Mellblom, Ellen Ruud, Jon Håvard Loge, Arnstein Finset
Journal: Int J Qual Stud Health Well-being (2016)
Keywords: aya, delivering bad news, case study, clinical communication, oncology
MeSH terms: Attitude to Health, Emotions, Neoplasms / diagnosis, Neoplasms / psychology, Physician-Patient Relations, Truth Disclosure, Observational Study, Adolescent, Adult, Child, Female, Humans, Male, Young Adult

Delivering the bad news of a cancer diagnosis to adolescent and young adult (AYA) patients who display strong emotions is particularly challenging not the least because AYAs are at a vulnerable developmental stage. Due to the lack of research on how to personalize the delivery of bad news to AYA patients' emotions we report a case study of the communicative behavior of oncologists in two such consultations to describe the complexity of the phenomena at study. We audio-recorded and transcribed consultations where oncologists delivered cancer diagnoses to nine AYAs aged 12-25 years. Two of these patients displayed particularly strong emotional behavior (anger, fear, and sadness) and were chosen as cases. An interpretative analysis in three steps was applied to investigate the oncologists' communicative behavior when delivering bad news. The focus was on how the oncologists responded to the strong but different emotional behaviors of the AYAs. We also related the oncologists' communicative behavior to elements from a widely used protocol for delivering bad news. We found that the oncologists applied five communication strategies: elicit patient perspective, provide information, respond to patient's expression of emotion (acknowledging and containing emotions), encourage commitment to treatment, and provide hope. The findings illustrate how oncologists' communicative behavior may be tailored to individual expressions of emotions in AYA cancer patients.
Metastatic mesenchymal chondrosarcoma showing a sustained response to cabozantinib: A case report
Authors: Veronika Blum, Vanghelita Andrei, Baptiste Ameline, Silvia Hofer, Bruno Fuchs, Klaus Strobel, Anna Allemann, Beata Bode, Daniel Baumhoer
Journal: Front Oncol (2022)
Keywords: cabozantinib, case report, mesenchymal chondrosarcoma, metastatic disease, p16 loss, tyrosine kinase inhibitors
MeSH terms: Case Reports

Mesenchymal chondrosarcoma is a rare and aggressive sarcoma subtype with high risk for distant metastases and poor prognosis. Currently NCCN- and ESMO-Guidelines recommend using Ewing sarcoma protocols as standard treatment. Nevertheless, in localized disease overall 5-year survival rates are below 50% whereas in metastatic spread median progression-free survival rates of only 5 months can be expected. Here we present a patient with metastatic osseous spread of mesenchymal chondrosarcoma that showed a sustained clinical improvement and a good partial response on imaging over a period of one year when treated with the multi-tyrosine kinase inhibitor cabozantinib. Although we cannot explain the exact mechanism underlying this treatment effect, tumors with similar genetic patterns might respond to the same therapy as well.
Multimodality imaging of a cardiac paraganglioma: A case report
Authors: Bruna Punzo, Dario Baldi, Brigida Ranieri, Carlo Cavaliere, Filippo Cademartiri
Journal: Front Cardiovasc Med (2023)
Keywords: cct, cmr, cardiac paraganglioma, case report, neuroendocrine tumor
MeSH terms: Case Reports

Cardiac paragangliomas (PGLs) are rare extra-adrenal tumors that arise from chromaffin cells of the sympathetic ganglia. PGLs are often diagnosed incidentally, in the absence of symptoms, or with symptoms related to cardiovascular dysfunction. Cardiac computed tomography (CCT) and cardiac magnetic resonance (CMR) can be used to accurately determine the lesion morphology and position as well as providing detailed tissue characterization. A multimodal imaging approach, not yet standardized, could be useful either in diagnosis and monitoring or in treatment planning. In the case reported here, CCT and CMR were performed to define lesion anatomy, and a reconstruction was generated using cinematic rendering (CR) to characterize the PGL angioarchitecture.
Pyloric Mucosal Diaphragm Associated with Hypertrophic Pyloric Stenosis: An Unusual Combination in a Male Neonate
Authors: Eugenie Chariot, Anna Poupalou, Julie Estievenart, Martine Dassonville, Erwin Vanderveken, Henri Steyaert
Journal: European J Pediatr Surg Rep (2020)
Keywords: congenital, diaphragm, hypertrophic, pyloric, stenosis
MeSH terms: Case Reports

We describe herein the case of a 3-week-old baby with persistent nonbilious vomiting, due to a hypertrophic pyloric stenosis (HPS) associated with a congenital pyloric mucosal diaphragm. So far, an association between the two conditions has not been described. The diagnosis of a pyloric mucosal diaphragm was delayed because of its cooccurrence with HPS.
Nonunion of a Stress Fracture at the Base of the Second Metatarsal in a Soccer Player Treated by Osteosynthesis with the Bridging Plate Fixation Technique
Authors: Futoshi Morio, Shota Morimoto, Shintaro Onishi, Toshiya Tachibana, Tomoya Iseki
Journal: Case Rep Orthop (2020)
MeSH terms: Case Reports

Background:
A stress fracture of the second metatarsal base in soccer players is extremely rare. In this case study, we report a nonunion of a stress fracture at the base of the second metatarsal in a female soccer player who had persistent pain despite continued conservative treatment, who then was treated with the bridging plate fixation technique. Case Report. A 19-year-old female college soccer player complained of pain on the dorsum of her right midfoot during a game without history of trauma and was conservatively treated for 6 months. Radiographic examination showed an oblique fracture with small bone fragment at the proximal base of the second metatarsal and computed tomography demonstrated sclerotic change around the fracture site. We diagnosed her with nonunion of a stress fracture at the base of the second metatarsal and performed operative treatments using autogenous cancellous iliac bone grafting and plate fixation bridging a second metatarsal and medial cuneiform with a locking plate. At 4 months after the initial surgery, she was able to return to playing soccer at preinjury level without complications or pain.
Conclusion:
We report a rare case of nonunion of a stress fracture at the base of the second metatarsal in a female soccer player without underlying diseases. Surgical treatment was applied, because the conservative treatment was ineffective for 6 months and led to nonunion. The plate fixation technique bridging the second metatarsal and medial cuneiform was a useful option to attain the bone fusion for small fracture fragment for a treatment of nonunion of a stress fracture at the base of the second metatarsal.
Atypical Manifestation of DRESS Syndrome
Authors: Christopher Hakim, Constantine Melitas, Eric Nguyen, Kha Ngo
Journal: Case Rep Gastrointest Med (2020)
MeSH terms: Case Reports

The differential for liver transaminases over 1000 units/liter typically includes liver ischemia, acute viral hepatitis, acetaminophen toxicity, and autoimmune hepatitis. Prompt evaluation is imperative as these etiologies can lead to fulminant liver failure. We present a case of transaminases over 1000 units/liter from an atypical etiology. A 52-year-old male, previously treated with allopurinol for an acute gout flare, presented with persistent fevers. Given that he had taken a "high-risk medication" 2-6 weeks before presentation, subsequently presented with fever, rash, renal impairment, elevated liver enzymes in the thousands, and peripheral eosinophilia, DRESS syndrome secondary to allopurinol was diagnosed.
Electroconvulsive Therapy in Functional Hallucination: Scope and Challenges
Authors: Sulochana Joshi, Rabi Shakya
Journal: Case Rep Psychiatry (2017)
MeSH terms: Case Reports

Functional hallucinations are hallucinations triggered by a stimulus in the same modality and cooccur with it. They are rare in occurrence; however, their rarity has no significance as psychopathology till date. Also, very little is known about the treatment of such hallucinations. Electroconvulsive therapy (ECT) has been tested for several psychiatric illnesses and has a few relative contraindications; however, it has not previously been used in treating functional hallucinations. We report on a female patient with paranoid schizophrenia who experienced functional hallucinations continuously despite the use of adequate risperidone, which controlled other symptoms. She was treated with ECT which resolved the functional hallucinations. The case highlights the need to ponder on the significance of the phenomenon as well as treatment of this psychopathology by ECT. It also underscores ECT as a treatment option for this kind of hallucination.