OpenMed/multicare-articles huggingface dataset:
Reverse strategy to locally advanced breast implant-associated anaplastic large cell lymphoma: A case report
Authors: Sonia Cappelli, Francesco Marchesi, Marco Clementi, Letizia Perracchio, Francesca Palombi, Fabio Pelle, Claudio Botti, Maurizio Costantini
Journal: Front Oncol (2023)
Keywords: breast implant-associated anaplastic large cell lymphoma (bia-alcl), conservative surgery, neoadjuvant chemotherapy, reverse-strategy, stem cell transplant
MeSH terms: Case Reports

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a rare T-cell lymphoma associated with textured breast implants. The most common presentation is a periprosthetic seroma that occurs at least 1 year after an aesthetic or reconstructive implantation, and in these cases, the surgical treatment seems to be successful. More rarely, BIA-ALCL presents with locally advanced mass-formed disease and a related regional lymph node involvement. In all these cases with worse prognosis, a multidisciplinary approach is required, including adjuvant chemotherapy, radiation therapy, and surgery. We present a clinical case of a 49-year-old woman who developed on the left side of the breast a mass-formed stage 3 BIA-ALCL 15 years after a bilateral breast augmentation with textured silicone implant. Our multidisciplinary team (MDT) scheduled the patient for a "reverse-strategy" sequential approach consisting of induction chemotherapy, hematopoietic stem cell mobilization, and harvest followed by autologous stem cell transplant (ASCT). After 100 days from the stem cell transplant, the patient showed a complete pathologic response and was a candidate for radical surgery. She underwent removal of both implants with total en bloc capsulectomy. On the left site, the periprosthetic mass was also en bloc removed. We did not perform any axillary dissection. Our surgical and hemato-oncological teams followed the patient every 3 months, and no local or systemic recurrences were observed 24 months after surgery. This case report has demonstrated the effectiveness of neoadjuvant chemotherapy as part of a "reverse strategy" in selected cases of advanced-stage BIA-ALCL in which it was not possible to perform an immediate radical surgery. Furthermore, in our case, the de-escalation strategy adopted permitted a less demolitic surgery with good functional and aesthetic results.
Denosumab chemotherapy for recurrent giant-cell tumor of bone: a case report of neoadjuvant use enabling complete surgical resection
Authors: Amit Agarwal, Brandon T Larsen, Lawrence D Buadu, Jack Dunn, Russell Crawford, Jonathan Daniel, Maria C Bishop
Journal: Case Rep Oncol Med (2013)

Giant-cell tumor of the bone (GCTB) is a rare neoplasm that affects young adults. The tumor is generally benign but sometimes can be locally aggressive. There are no standardized approaches to the treatment of GCTB. Recently, the RANKL inhibitor denosumab has shown activity in this tumor type. We present the case of a young female who presented with locally advanced disease and was successfully managed with the neoadjuvant use of denosumab allowing for surgical resection of the tumor that was previously deemed unresectable. Following surgery, the patient is being managed with continued use of denosumab as 'maintenance,' and she continues to be free of disease. Our case highlights a novel approach for the management of locally advanced and aggressive giant cell tumor of the bone.
Pseudomyxoma Peritonei: A Case Report Diagnosed in a 47-Year-Old Woman with Chronic Pelvic Abdominal Pain and Appendicular Origin: Review of the Literature and Management
Authors: Francois Pugin, Jean Bouquet De Jolinière, Attila Major, Fathi Khomsi, Louis Guillou, Mathias Peter, Nordine Ben Ali, Bernhard Egger, Anis Feki
Journal: Front Surg (2017)
Keywords: appendicitis, intraperitoneal chemotherapy, laparoscopic surgery, mucoid ovarian cyst, ovarian cancer, pseudomyxoma peritonei
MeSH terms: Case Reports

The authors report a case of pseudomyxoma peritonei with gelatinous peritoneum in a 47-year-old-woman. The main symptom for discovery was a chronic pelvic abdominal pain. This disease is particularly rare. The gelatinous substance is often associated with a malignant ovarian tumor or appendicitis perforated. Currently, on the whole, an exploratory laparoscopy allows diagnosis, biopsies, and appendectomy. The treatment is essentially surgical. The prognosis depends on grade (1/3) and response to chemotherapy. This case was presented to the tumor board.
Imagery Rescripting on Guilt-Inducing Memories in OCD: A Single Case Series Study
Authors: Katia Tenore, Barbara Basile, Teresa Cosentino, Brunetto De Sanctis, Stefania Fadda, Giuseppe Femia, Andrea Gragnani, Olga I Luppino, Valerio Pellegrini, Claudia Perdighe, Giuseppe Romano, Angelo M Saliani, Francesco Mancini
Journal: Front Psychiatry (2020)
Keywords: criticism, guilt, imagery rescripting, memories, obsessive-compulsive disorder

Background and objectives:
Criticism is thought to play an important role in obsessive-compulsive disorder (OCD), and obsessive behaviors have been considered as childhood strategies to avoid criticism. Often, patients with OCD report memories characterized by guilt-inducing reproaches. Starting from these assumptions, the aim of this study is to test whether intervening in memories of guilt-inducing reproaches can reduce current OCD symptoms. The emotional valence of painful memories may be modified through imagery rescripting (ImRs), an experiential technique that has shown promising results.
Methods:
After monitoring a baseline of symptoms, 18 OCD patients underwent three sessions of ImRs, followed by monitoring for up to 3 months. Indexes of OCD, depression, anxiety, disgust, and fear of guilt were collected.
Results:
Patients reported a significant decrease in OCD symptoms. The mean value on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) changed from 25.94 to 14.11. At the 3-month follow-up, 14 of the 18 participants (77.7%) achieved an improvement of ≥35% on the Y-BOCS. Thirteen patients reported a reliable improvement, with ten reporting a clinically significant change (reliable change index = 9.94). Four reached the asymptomatic criterion. Clinically significant changes were not detected for depression and anxiety.
Conclusions:
Our findings suggest that after ImRs intervention focusing on patients' early experiences of guilt-inducing reproaches there were clinically significant changes in OCD symptomatology. The data support the role of ImRs in reducing OCD symptoms and the previous cognitive models of OCD, highlighting the role of guilt-related early life experiences in vulnerability to OCD.
Bradycardia during Induction Therapy with All- trans Retinoic Acid in Patients with Acute Promyelocytic Leukemia: Case Report and Literature Review
Authors: Pin-Zi Chen, Yee-Jen Wu, Chien-Chih Wu, Yu-Wen Wang
Journal: Case Rep Hematol (2018)
MeSH terms: Case Reports

A 41-year-old man with newly diagnosed acute promyelocytic leukemia (APL) received induction chemotherapy, containing all-trans retinoic acid (ATRA), idarubicin, and arsenic trioxide. On the 11th day of therapy, he experienced complete atrioventricular (AV) block; therefore, ATRA and arsenic trioxide were immediately postponed. His heart rate partially recovered, and ATRA was rechallenged with a half dose. However, complete AV block as well as differentiation syndrome recurred on the next day. ATRA was immediately discontinued, and a temporary pacemaker was inserted. Two days after discontinuing ATRA, AV block gradually improved, and ATRA was uneventfully rechallenged again. The Naranjo adverse drug reaction probability scale was 7 for ATRA, suggesting it was the probable cause of arrhythmia. A literature search identified 6 other cases of bradycardia during ATRA therapy, and all of them occurred during APL induction therapy, with onset ranging from 4 days to 25 days. Therefore, monitoring vital signs and performing electrocardiogram are highly recommended during the first month of induction therapy with ATRA. ATRA should be discontinued if complete AV block occurs. Rechallenging with ATRA can be considered in fully recovered and clinically stable patients.
Coordinating health promotion in a federal state over the course of 30 years: a case report from Switzerland
Authors: Thomas Mattig
Journal: Health Promot Perspect (2019)
Keywords: health policy, health promotion, prevention
MeSH terms: Case Reports

In a federal state such as Switzerland, the 26 cantons enjoy wide autonomy in all policy areas, including health policy. In the late 1980s, after the signing of the Ottawa Charter for health promotion, the Swiss Confederation and the cantons decided to create a foundation whose goal it was to initiate, coordinate and evaluate health promotion and disease prevention activities throughout the country. Thirty years later, the many stakeholders in the field have accepted health Promotion Switzerland as a key actor. The foundation was able to successfully initiate and coordinate projects in such priority areas as "Healthy Body Weight," "Mental Health -Stress" and "Strengthening Health Promotion & Prevention." But several challenges remain, for example, chronic noncommunicable diseases, an aging population, mental disorders, prevention in healthcare-challenges the foundation will have to face and to which it is expected to provide solutions.
Effectiveness and safety of morinidazole in the treatment of pelvic inflammatory disease: A multicenter, prospective, open-label phase IV trial
Authors: Ting Zhou, Ming Yuan, Pengfei Cui, Jingjing Li, Feifei Jia, Shixuan Wang, Ronghua Liu
Journal: Front Med (Lausanne) (2022)
Keywords: anaerobes, levofloxacin, morinidazole, pelvic inflammatory disease, safety
MeSH terms: Case Reports

Background:
Antimicrobial resistance to metronidazole has emerged after several decades of worldwide use of the drug. The purpose of this study was to evaluate the effectiveness, safety and population pharmacokinetics of morinidazole plus levofloxacin in adult women with pelvic inflammatory disease (PID).
Methods:
Patients in 30 hospitals received a 14-day course of 500 mg intravenous morinidazole twice daily plus 500 mg of levofloxacin daily. A total of 474 patients were included in the safety analysis set (SS); 398 patients were included in the full analysis set (FAS); 377 patients were included in the per protocol set (PPS); 16 patients were included in the microbiologically valid (MBV) population.
Results:
The clinical resolution rates in the FAS and PPS populations at the test of cure (TOC, primary effectiveness end point, 7-30 days post-therapy) visit were 81.91 and 82.49% (311/377), respectively. There were 332 patients who did not receive antibiotics before treatment, and the clinical cure rate was 82.83%. Among 66 patients who received antibiotics before treatment, 51 patients were clinically cured 7-30 days after treatment, with a clinical cure rate of 77.27%. The bacteriological success rate in the MBV population at the TOC visit was 87.5%. The minimum inhibitory concentration (MIC) values of morinidazole for use against these anaerobes ranged from 1 to 8 μg/mL. The rate of drug-related adverse events (AEs) was 27.43%, and no serious AEs or deaths occurred during the study.
Conclusions:
The study showed that treatment with a 14-day course of intravenous morinidazole, 500 mg twice daily, plus levofloxacin 500 mg daily, was effective and safe. The results of this study were consistent with the results of a phase III clinical trial, which verified the effectiveness and safety of morinidazole.
A surprising finding after external ear polypectomy in a deaf mute patient
Authors: Hazem M Abdel Tawab, Ravi Kumar V, Salim M Sloma Tabook
Journal: Case Rep Otolaryngol (2015)

Introduction. External auditory canal polyps usually reflect an inflammatory process. Rarely, they may reflect a serious condition that warrants urgent intervention. Case Report. A 19-year-old deaf mute female presented to our department with persistent left ear discharge and a reddish mass in the ear. After surgery, the cause was identified as a neglected foreign body. Tympanic membrane was intact. Conclusion. Aural polyp that is resistant to medical treatment should raise the suspicion of an inflammatory polyp with underlying chronic suppurative otitis media or foreign body. Rarer neoplastic and immunological causes should also be considered.
Klippel-Feil Syndrome with Sprengel Deformity and Extensive Upper Extremity Deformity: A Case Report and Literature Review
Authors: John W Stelzer, Miguel A Flores, Waleed Mohammad, Nathan Esplin, Jonathan J Mayl, Christopher Wasyliw
Journal: Case Rep Orthop (2018)
MeSH terms: Case Reports

Introduction:
Klippel-Feil syndrome (KFS) is a congenital anomaly resulting from fusion of cervical vertebral bodies secondary to the dysregulation of signaling pathways during somite development. It is commonly associated with scoliosis and Sprengel deformity. We present a case of KFS with commonly associated abnormalities as well as deformities that have not yet been reported in the literature.
Case presentation:
A 3-year-old girl presented for further evaluation of a left upper extremity deformity following a negative genetic workup. Upon physical exam and radiographic imaging, the patient was diagnosed with KFS and associated abnormalities including cervical scoliosis, Sprengel deformity, and congenital deformity of the left upper extremity. Deformities of the left upper extremity include radioulnar synostosis, a four-rayed hand, and absent thenar musculature. The Sprengel deformity was corrected surgically with a Woodward procedure.
Discussion:
Congenital musculoskeletal deformities can be differentiated based upon spinal and limb embryology. The presence of extraspinal abnormalities not originating from somite differentiation may suggest a severe form of KFS. Important considerations in the workup of the KFS patient include looking for deformities of the shoulder girdle and upper extremities to identify abnormalities for intervention at a young age.
Round Ligament Leiomyoma Presenting as an Incarcerated Inguinal Hernia: Case Report and Review of the Literature
Authors: Marc Najjar, Marc Mandel
Journal: Case Rep Surg (2016)

Leiomyomas are common benign gynecologic tumors occurring in up to 30% of women. Round ligament leiomyomas however are very rare and, if symptomatic, can present as an inguinal hernia. We report the case of a 47-year-old woman who presented with an irreducible inguinal mass consistent with an incarcerated hernia. Intraoperatively, the mass was found to be a round ligament leiomyoma, a diagnosis that was confirmed by histopathology following excision of the mass. Although rare, round ligament leiomyomas should be part of the differential diagnosis of an inguinal hernia in females.
Recurrent PET FDG Uptake after Sequential Chemotherapy and Radiation Therapy for DLBCL of the Tibia: A Case Report and Review of the Literature
Authors: Edward F Miles, Luke Balsamo, David B Turton, William Graf
Journal: Case Rep Oncol Med (2011)
MeSH terms: Case Reports

The aim of this paper is to report on the challenges associated with identifying disease recurrence following combined modality therapy (CMT) for primary lymphoma of the tibia in which an intramedullary nail has been placed. A patient with primary bone lymphoma (PBL) was treated with CMT (chemotherapy and radiation therapy). After a complete response, he has been followed for eighteen months by physical exam and radiographic imaging. Despite persistent increased tracer accumulation at the original site, he has no proven recurrence. Literature review showed a small number of retrospective, single institution reviews detailing clinical experience and expected outcome in patients treated with PBL limited to one bony site of disease. PBL presents a treatment challenge, particularly when a weight-bearing long bone is diffusely involved and followup is complicated after placement of stabilizing hardware. Close coordination of the oncology team and diagnostic radiology is required to ensure optimal outcome.
A rare anomaly of A4+5 on three-dimension multidetector computed tomography in lung cancer: A case report
Authors: Shinichi Sakamoto, Hiromasa Matsumoto, Hiroyuki Hino, Shoji Sakiyama
Journal: Int J Surg Case Rep (2019)
Keywords: anomaly, three-dimension multidetector computed tomography, video-assisted thoracic surgery

Introduction:
There are several anomalies of the pulmonary vessels. Clinicians need to be well informed about anatomy, particularly before video-assisted thoracic surgery, to prevent fatal complications.
Presentation of case:
We report the case of an 80-year-old woman who was suspected of having lung cancer in the right lower lobe. The patient was accordingly scheduled for surgery. Three-dimension multidetector computed tomography (3D-MDCT) showed an extremely rare anomaly in which A4 + 5 ran between V2 and V1 + 3. We scheduled a non-anatomical wedge resection of the lesion and performed rapid pathological diagnosis during surgery. Because adenocarcinoma was diagnosed, we performed right lower lobectomy using video-assisted thoracic surgery. Station 11i lymph node rigidly adhered to the main pulmonary artery, V2, and intermedius bronchus. Thus, the surgery was shifted to middle and lower lobectomy.
Discussion:
To the best of our knowledge, this type of anomaly has not been reported yet. Pulmonary vessels can be accurately identified using 3D-MDCT; thus, a rare anatomy can be identified, and information can be shared across the surgical team simulating familiarity with this rare anatomy.
Conclusion:
Using 3D-MDCT, we could accurately divide A4 + 5 and safely perform the surgery.
Post-COVID isolated subclavian artery dissection with multiple cerebral infarctions
Authors: Taha K Alloush, Adel T Alloush, Fayez Marzouk, Khaled O Abdulghani, Hossam M Shokri
Journal: Egypt J Neurol Psychiatr Neurosurg (2022)
Keywords: covid-19, cerebral infarction, limb ischemia, subclavian dissection
MeSH terms: Case Reports

Background:
Coronavirus disease 2019 (COVID-19) is a pandemic disease which predominantly affects the respiratory system with high critical care mortality and morbidity, yet it also causes multiple organs dysfunction in affected patients. There is a strong evidence that it increases the susceptibility of cerebrovascular strokes in such patients. Besides this prothrombotic complication, arterial dissection can be one of its mechanisms increasing the risks of stroke.
Case presentation:
Herein, we report a case of spontaneous isolated subclavian artery dissection in a COVID-19 patient. Sixty-one-year-old female presented with spontaneous isolated subclavian artery dissection without any traumatic events nor history of connective tissue disorders. She had left upper limb ischemia followed by cerebellar, thalamic and occipital infarctions. Whether this patient's subclavian artery dissection was triggered by exaggerated inflammatory response or arteriopathy secondary to COVID-19 remains speculative.
Conclusions:
Nonetheless, arterial dissection can be one of its complications, it is essential for treating physicians to be attentive for the diversity of COVID-19 clinical manifestations.
Case report: A novel de novo IGF2 missense variant in a Finnish patient with Silver-Russell syndrome
Authors: Petra Loid, Marita Lipsanen-Nyman, Sirpa Ala-Mello, Katariina Hannula-Jouppi, Juha Kere, Outi Mäkitie, Mari Muurinen
Journal: Front Pediatr (2022)
Keywords: igf2, silver-russell, exome sequencing, intrauterine growth restriction, short stature
MeSH terms: Case Reports

Silver-Russell syndrome (SRS, OMIM 180860) is a rare imprinting disorder characterized by intrauterine and postnatal growth restriction, feeding difficulties in early childhood, characteristic facial features, and body asymmetry. The molecular cause most commonly relates to hypomethylation of the imprinted 11p15.5 IGF2/H19 domain but remains unknown in about 40% of the patients. Recently, heterozygous paternally inherited pathogenic variants in IGF2, the gene encoding insulin-like growth factor 2 (IGF2), have been identified in patients with SRS. We report a novel de novo missense variant in IGF2 (c.122T > G, p.Leu41Arg) on the paternally derived allele in a 16-year-old boy with a clinical diagnosis of SRS. The missense variant was identified by targeted exome sequencing and predicted pathogenic by multiple in silico tools. It affects a highly conserved residue on a domain that is important for binding of other molecules. Our finding expands the spectrum of disease-causing variants in IGF2. Targeted exome sequencing is a useful diagnostic tool in patients with negative results of common diagnostic tests for SRS.
Maintenance Therapy Containing Metformin and/or Zyflamend for Advanced Prostate Cancer: A Case Series
Authors: Mehmet Asim Bilen, Sue-Hwa Lin, Dean G Tang, Kinjal Parikh, Mong-Hong Lee, Sai-Ching J Yeung, Shi-Ming Tu
Journal: Case Rep Oncol Med (2015)

Metformin is derived from galegine, a natural ingredient, and recent studies have suggested that metformin could enhance the antitumor effects of hormone ablative therapy or chemotherapy and reduce prostate cancer-specific mortality. Zyflamend is a combination of herbal extracts that reduces inflammation and comprises turmeric, holy basil, green tea, oregano, ginger, rosemary, Chinese goldthread, hu zhang, barberry, and basil skullcap. We propose a maintenance regimen with metformin and/or Zyflamend that targets cancer stem cells and the tumor microenvironment to keep the cancer dormant and prevent it from activation from dormancy. Herein, we report the clinical course of four patients who experienced a clinical response after treatment with metformin and/or Zyflamend.
Severe Hemolysis in a COVID-19 Patient with Paroxysmal Nocturnal Hemoglobinuria
Authors: Steve Biko Otieno, Alaa Altahan, Fnu Kaweeta, Saradasri Karri, Fnu Alnoor, Robert Johnson
Journal: Case Rep Hematol (2021)
MeSH terms: Case Reports

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), has been demonstrated to be able to activate complement, making patients with deficiency in negative complement regulation, such as paroxysmal nocturnal hemoglobinuria (PNH), particularly vulnerable to complement-mediated cell damage. We report a case of a patient who presented with fatigue, facial swelling, and upper respiratory infection (URI) symptoms and was found to have COVID-19 with laboratory tests showing severe hemolysis and pancytopenia secondary to PNH.
Tooth fragment embedded in the lower lip for 10 months following dentoalveolar trauma: A case report with literature review
Authors: N B Nagaveni, K V Umashankara
Journal: Burns Trauma (2014)
Keywords: fractured incisor, lip laceration, tooth embedding
MeSH terms: Case Reports

Traumatic injuries to maxillary anterior teeth are a common finding in children because of falls while playing. Sequelae of trauma to dental hard tissue include broken, lost, aspirated and swallowed teeth. One additional hazard is the embedding of fractured tooth fragments in the soft tissues, particularly in the lip. A 10-year-old male patient complained of pain in the lower lip. There was a history of trauma to the upper anterior tooth 10 months previously. Clinical examination showed scarring and discoloration over the lower lip, and the presence of a hard mass was felt on palpation. Intraoral examination revealed an Ellis and Davey class II fracture of number 11. A radiograph of the lip was taken, which showed a radiopaque structure similar to the shape of the missing tooth fragment. Under local anesthesia, the tooth fragment was removed successfully, and the class II fracture was restored with composite. Therefore, proper clinical and complete radiographic examination of both hard and soft tissues following dental trauma is essential to rule out such occurrences.