OpenMed/multicare-articles huggingface dataset:
Case Report: Systemic Sclerosis After Covid-19 Infection
Authors: Serena Fineschi
Journal: Front Immunol (2021)
Keywords: covid-19, autoimmunity, long covid, scleroderma, systemic sclerosis
MeSH terms: Autoimmune Diseases / etiology, Autoimmunity, COVID-19 / complications, SARS-CoV-2 / genetics, Scleroderma, Systemic / etiology, Case Reports, Autoantibodies / immunology, COVID-19 / immunology, COVID-19 / virology, Calcium Channel Blockers / therapeutic use, Follow-Up Studies, Humans, Lung Diseases, Interstitial / diagnostic imaging, Lung Diseases, Interstitial / etiology, Male, Middle Aged, Post-Acute COVID-19 Syndrome, Proton Pump Inhibitors / therapeutic use, Raynaud Disease / diagnosis, Raynaud Disease / etiology, Scleroderma, Systemic / drug therapy, Tomography, X-Ray Computed, Treatment Outcome, Autoantibodies, Calcium Channel Blockers, Proton Pump Inhibitors

The coronavirus disease (COVID-19) is a respiratory tract infection caused by the new virus SARS-CoV-2. The acute phase of the infection may in certain individuals be followed by another longer phase of disease (long COVID) of unknown etiology probably associated in certain cases with autoimmune activation. It has been shown that COVID-19 can trigger autoantibody production and in genetically predisposed patients may cause the onset or exacerbation of autoimmune diseases. We are reporting a case of mild COVID-19 infection complicated by autoantibody production and cutaneous and gastrointestinal symptoms and subsequently diagnosed with systemic sclerosis (SSc). A 47-year-old man with no history of any autoimmune diseases and in good health became sick together with his family on the 12th of November with mild symptoms: tiredness, fever, cough, and sore throat. Oropharyngeal swab for SARS-CoV-2 tested positive. He was isolated at home and did not require hospitalization. Three weeks later he presented with clinical manifestation compatible with suspicion of SSc. He briefly presented with skin rush, periorbital edema and conjunctivitis, vomiting, dysphagia, burning sensation in the skin, above all in the fingertips and around the mouth, puffy fingers, Raynaud's phenomenon, pain at the fingertip of the middle finger where a depressed area was noticed without a clear ulceration. ANA showed a strongly positive nucleolar pattern. Anti-PM/Scl 75 and PM/Scl 100 resulted positive. High-resolution computed tomography (HCRT) showed early stage of interstitial lung disease (ILD). The patient was diagnosed with SSc based on the persistence of autoantibodies and the clinical and radiological pictures according to the ACR/EULAR classification (scores: puffy finger, 2; ILD, 2; Raynaud's phenomenon, 3; SSc related antibodies, 3; total 10). There are several cases described in the medical literature of possible new onset of SLE after COVID-19 infection. This is the first case that describes a possible new onset of SSc. Conclusion: SARS-CoV-2 may trigger systemic sclerosis.
A case of endometrioid adenocarcinoma arising from adenomyosis
Authors: Shigeki Taga, Mari Sawada, Aya Nagai, Dan Yamamoto, Ryoji Hayase
Journal: Case Rep Obstet Gynecol (2014)

Malignant changes in endometriosis are often reported, but those in adenomyosis are rare. We report a case of endometrioid adenocarcinoma arising from adenomyosis. Case Presentation. A 57-year-old woman presenting with vaginal bleeding was referred to our hospital. Cytological tests of endometrium revealed atypical glandular cells. Fractional endometrial curettage revealed normal endometrium without atypia. Magnetic resonance imaging (MRI) revealed multiple myomas. The endometrium was slightly enhanced on T1-weighted imaging and endometrial cancer was suspected. Myometrial invasion was not evident. The patient was admitted and semiradical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy was performed. Histopathological study revealed grade 1 endometrioid adenocarcinoma. Although the lesion was located in the muscle layer of the corpus and invaded more than half of it, the endometrium was intact. Pelvic lymph node metastasis was noticed. No cervical invasion or metastasis to the adnexa was seen. We diagnosed the case with a stage 1B endometrioid adenocarcinoma originating from adenomyosis. Adjuvant chemotherapy was then performed in the form of 5 cycles of paclitaxel (180 mg/m(2)) and carboplatin (AUC = 5). Five years later, right lung metastasis and right para-aortic and pelvic lymph nodes metastasis were noticed. Paclitaxel and carboplatin are now being administered.
Orbital and adnexal tuberculosis: a case series from a South Indian population
Authors: Kalpana Babu, Moupia Mukhopadhyay, Soumya S Bhat, Jt Chinmayee
Journal: J Ophthalmic Inflamm Infect (2014)
Keywords: antitubercular therapy, mycobacterium tuberculosis, orbital tuberculosis, proptosis

Background:
Orbital tuberculosis (OTb) is rare and may be regarded as a manifestation of extrapulmonary tuberculosis. We report an interesting case series of six patients with varied presentations of orbital and adnexal tuberculosis in a South Indian patient population.
Results:
A retrospective, interventional case series of six patients diagnosed with orbital and adnexal tuberculosis on the basis of clinical, radiological and histopathological evaluations between 2010 and 2013 was performed. Among the six patients with histopathologically proven OTb, five were women. The varied presentations included tubercular dacryoadenitis (two cases), classical periostitis (two cases), OTb with bone involvement (one case) and ocular adnexal tuberculosis (one case). Systemic involvement was seen in one case. All cases were treated with a regimen of antitubercular therapy (ATT).
Conclusions:
OTb, though rare, should form a part of the differential diagnosis of orbital lesions in a high tuberculosis (TB) endemic country like ours. Biopsy still remains the mainstay of diagnosis.
Full-endoscopic uniportal retropharyngeal odontoidectomy: A preliminary case report
Authors: Jichao Ye, Bin Liu, Jinteng Li, Guan Zheng, Kaidi Duan, Liangbin Gao, Chunyan Zhang, Jingwen Huang, Yong Tang
Journal: Front Surg (2023)
Keywords: axis, basilar invagination, endoscopy, odontoidectomy, trans-cervical approach
MeSH terms: Case Reports

Summary of background data:
Odontoidectomy aims to decompress the medulla oblongata and is usually performed through the classical transoral approach, which affects oropharynx and accompanied with high rate of complications comprising swallowing and respiratory tract. We have developed a minimal invasive method via a standard cervical anterior approach: full-endoscopic trans-cervical odontoidectomy, which provides an alternative access for the resection of odontoid process and medulla oblongata decompression without traversing potentially contaminated cavities.
Methods:
From 2018 to 2020, three patients with either odontoid process lesion or basilar invagination underwent full-endoscopic uniportal trans-cervical odontoidectomy with/without combining the posterior instrumentation. With fluoroscopic guidance, a uniportal endoscope sleeve was placed inside of the odontoid process; then odontoid process was gradually resected from the inside to outside under endoscopic monitoring. Postoperative images and clinical data were collected during post-op follow-up.
Result:
Patients were soon extubated after surgery when patients wake up from general anesthesia. There were no severely perioperative complications, especially dysphagia and airway obstruction, and the symptoms and neurological function was improved immediately after surgery. The final pathology of one patient with odontoid osteolytic lesion was confirmed as plasmacytoma. The postoperative CT scans proved that the range of odontoid process resection was consistent with the preoperative expectation.
Conclusion:
In summary, our proposed endoscopic trans-cervical odontoidectomy provides a valid choice for non-oral approach, which would reduce postoperative approach related complications and accelerate postoperative recovery.
Histological subtype of gastric adenocarcinoma: two cases of mixed fundic and pyloric mucosa-type adenocarcinoma
Authors: Haruhiko Takahashi, Kenshi Yao, Tetsuya Ueo, Takashi Nagahama, Kentaro Imamura, Kenta Chuman, Hiroshi Tanabe, Akinori Iwashita, Toshiharu Ueki
Journal: Ecancermedicalscience (2020)
Keywords: early gastric cancer, gastric phenotype, magnifying narrow-band imaging
MeSH terms: Case Reports

Adenocarcinomas with differentiation towards fundic or pyloric glands are rare histological subtypes. We herein describe two cases of new histological subtypes: mixed fundic and pyloric mucosa-type adenocarcinoma detected in Helicobacter pylori uninfected patients. The first patient was a woman in her 40s. A glossy, reddish, nodular lesion with a flat elevated whitish area was detected at the gastric fundus. When the nodular lesion was visualised with magnifying narrow-band imaging (M-NBI), an absent microvascular pattern plus an irregular microsurface pattern with a demarcation line was observed. The second patient was a woman in her 60s. A glossy, reddish, elevated lesion was detected at the gastric body. M-NBI finding was a regular microvascular pattern plus a regular microsurface pattern with a demarcation line. Histological examination of the resected specimens from both cases showed a very well- to well-differentiated adenocarcinoma which has differentiation towards the mixed fundic and pyloric mucosa. The histological and serological findings of both cases indicated the absence of H. pylori infection. The present two cases demonstrate further evidence of a new histological subtype of gastric adenocarcinoma: mixed fundic and pyloric mucosa-type adenocarcinoma, which has distinct characteristic endoscopic findings.
Weismann-Netter-Stuhl syndrome: a family report
Authors: Hayrullah Alp, Mehmet Emre Atabek, Özgür Pirgon
Journal: J Clin Res Pediatr Endocrinol (2009)
Keywords: weismann-netter-stuhl syndrome, femur involvement, radiography
MeSH terms: Bone Diseases, Developmental / diagnosis, Bone Diseases, Developmental / genetics, Genu Varum / diagnosis, Genu Varum / genetics, Case Reports, Adult, Bone Diseases, Developmental / diagnostic imaging, Family, Female, Femur / abnormalities, Fibula / abnormalities, Genu Varum / diagnostic imaging, Humans, Infant, Male, Radiography, Tibia / abnormalities, Turkey, Weismann Netter syndrome

Weismann-Netter-Stuhl (WNS) syndrome is a rare skeletal anomaly that affects the diaphyseal part of both the tibiae and fibulae with posterior cortical thickening and anteroposterior bowing. This anomaly is usually bilateral and symmetrical. The patients are generally of short stature. In some cases, a family history suggesting genetic transmission of a mutation with an unknown locus has been reported. In this paper we present an infant with WNS syndrome with bilateral involvement of the femur. Similar clinical findings were defined in three other family members.
Complete Penoscrotal Transposition with Other Extragenital Anomalies in a Neonate Delivered at Term
Authors: Ali Mahamudu Ayamba, Raymond Saa-Eru Maalman, Yaw Otchere Donkor, John Noah Anyorigiya
Journal: Case Rep Urol (2021)
MeSH terms: Case Reports

A complete penoscrotal transposition (CPST) is a very uncommon congenital maldevelopment that is always associated with other abnormal body variations (malformations). We report a rare case of a term neonate delivered with CPST, which had a flaccid penis and an intact scrotum with unilateral limb and digital deformity, imperforate anus, cardiac malformation a facial deformity. Neonate died two hours after delivery. The foetal abnormality was not detected through routine antenatal services received by the mother.
Management of retained trans-anal foreign body: a case report
Authors: Edward Asumanu, Clement Nii Akwei Akwei, Abdullai Saeed, Jermaine Addai
Journal: Pan Afr Med J (2022)
Keywords: retained foreign body, anal sphincter, body spray can, case report
MeSH terms: Colonic Diseases, Foreign Bodies, Case Reports, Adult, Anal Canal, Humans, Male

Management of retained trans-anal foreign bodies is yet to be standardized. We present a case of how a retained trans-anal colonic body spray can affect the anal sphincter and its effect on management. A male adult presented with a retained trans-anal body spray can in the colon and a weakened anal sphincter. A plain abdominal X-ray and colonoscopy confirmed the diagnosis. After a failed endoscopic removal, a non-operative manual removal was done. Sphincter tone improved 3 days later. The article describes anal sphincter weakness, patient categorization, and non-operative management of the retained colonic foreign body.
Clinicopathological Features of Thyroid-Like Low-Grade Nasopharyngeal Papillary Adenocarcinoma: A Case Report and Review of the Literature
Authors: Hiromasa Takakura, Takeru Hamashima, Hirohiko Tachino, Akira Nakazato, Hiroshi Minato, Masakiyo Sasahara, Hideo Shojaku
Journal: Front Surg (2020)
Keywords: clinicopathological features, endoscopic resection, thyroglobulin, thyroid transcription factor-1, thyroid-like low-grade nasopharyngeal papillary adenocarcinoma
MeSH terms: Case Reports

Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is an extremely rare neoplasm of the nasopharynx. Accordingly, its clinical and pathological characteristics are not well-known. We report a case of TL-LGNPPA and review the relevant literature on TL-LGNPPA. A 38-year-old Japanese woman presented with a history of nasal obstruction that had persisted for 1 month after symptoms of a common cold (e.g., low-grade fever, sore throat, and fatigue). A pedunculated tumor of ~20 mm in diameter was found on the posterior edge of the nasal septum. The tumor was endoscopically resected. Based on careful histopathological and immunohistochemical examinations, it was diagnosed as TL-LGNPPA. At 5 years after surgery, the patient remained disease-free. TL-LGNPPA has a very good prognosis, and complete resection with a sufficient safety margin is recommended as the first-line treatment. The morphological characteristics and immunohistochemical findings, especially TTF-1 positivity and thyroglobulin negativity, are important for the diagnosis.
Endovascular embolization of ruptured infundibular dilation of posterior communicating artery: a case report
Authors: Jinlu Yu, Honglei Wang, Kan Xu, Bai Wang, Qi Luo
Journal: Case Rep Med (2010)
MeSH terms: Case Reports

Hemorrhage due to the rupture of the infundibular dilatation of the posterior communicating artery (ID of the PCo-A) occurs infrequently. The preferred treatment of such hemorrhages is surgical clipping through craniotomy. There are few reports about endovascular coil embolization in such cases. We report such a case treated by endovascular embolization. A 35-year-old man, who had experienced 2 episodes of subarachnoid hemorrhage (SAH), was found to have a ruptured ID of the PCo-A by head computed tomography angiography (CTA) and digital subtraction angiography (DSA). We performed stent-assisted endovascular coil embolization through a combined anterior and posterior circulation approach. Postembolization angiography showed absence of contrast filling of the ID of the PCo-A and nonleakage of the contrast agent. The patient recovered well with no complications. SAH recurrence was not recorded during the 1-year followup. The postoperative angiographic result was good. To our knowledge, this is the first case of hemorrhage due to ruptured ID of the PCo-A that was treated by such a technique.
T-Cell Large Granular Lymphocytic Leukemia with Extremely Rare Immunophenotype (CD4/CD8 Double-Positive) Followed by Multiple Myeloma Diagnosis
Authors: Dina Soliman, Sherin Sallam, Susanna Akiki, Deena Mudawi, Feryal Ibrahim
Journal: Case Rep Hematol (2020)
MeSH terms: Case Reports

T-cell large granular lymphocytic leukemia is characterized by clonal expansion of a CD3+/CD57+ subpopulation, which are typically CD8+ positive cytotoxic T- cells, and can only be diagnosed if there is a persistent, greater than 6 months, elevation of LGL in the blood (usually 2-20 × 109/L), in the absence of an identifiable cause. T-LGLL has been associated with reactive conditions such as autoimmune diseases and viral infections and has also been reported in association with hematologic and non-hematologic malignancies. We report a case of asymptomatic CD4/CD8 double-positive T-LGLL. Flow cytometry on peripheral blood revealed a subpopulation of CD4/CD8 double-positive T cells expressing CD57 and cTIA. Clonality was established by flow cytometric analysis of T-cell receptor V(â) region repertoire which showed that >70% of the cells failed to express any of the tested V(â) regions. Clonality was further confirmed by PCR with the detection of clonal TCR beta and TCR gamma gene rearrangements. Six months later, she presented with persistent lower back pain and diagnosed with IgG kappa multiple myeloma. CD4/CD8 double-positive T-large granular leukemia is the first case reported in the literature. This rare phenotype is either underreported or a truly rare clinical entity. More studies are warranted to characterize the pathogenesis and clinical characteristics of this group of patients and to further assess the relationship between multiple myeloma and T-LGLL as a cause-and-effect relationship or simply related to the time at which diagnosis has been made.
Case report: Endovascular intervention of internal carotid artery pseudoaneurysm secondary to nasopharyngeal carcinoma radiotherapy
Authors: Chao Li, Jiachao Lu, Yu Luo, Daqin Feng
Journal: Front Surg (2023)
Keywords: case report, endovascular intervention, internal carotid artery pseudoaneurysm, nasal bleeding, nasopharyngeal carcinoma
MeSH terms: Case Reports

Background:
Internal carotid artery pseudoaneurysm (PSA) is a serious complication after radiotherapy for nasopharyngeal carcinoma, and once it ruptures and bleeds, it will seriously affect the patient's survival and prognosis. However, because of its relatively low incidence, many medical institutions lack experience in managing this type of emergency.
Case information:
In this case report, we described two cases suffered ruptured internal carotid artery PSA after radiotherapy for nasopharyngeal carcinoma, including their history, diagnosis, and treatment. Both cases underwent emergency endovascular interventions, one of which with long-term healing after embolization of the PSA, and the other one with re-bleeding after embolization and was eventually stopped by embolization of the parent artery. Ultimately, both cases received timely and effective treatment.
Conclusion:
This case report detailed the diagnosis and treatment course of internal carotid artery PSA after radiotherapy for nasopharyngeal carcinoma, which enhanced the understanding of this emergency, and provided valuable information and experience for the treatment strategy of similar PSA on the internal carotid artery.
Multiple liver abscesses and bacteremia caused by Streptococcus constellatus infection: a case report
Authors: Nobuhiro Akuzawa, Takashi Hatori, Yonosuke Kitahara, Masahiko Kurabayashi
Journal: Clin Case Rep (2016)
Keywords: abdominal ultrasonography, streptococcus milleri group, computed tomography, diverticulitis, liver abscess
MeSH terms: Case Reports

The Streptococcus milleri group (SMG) comprises commensal mucosal bacteria. Pyogenic liver abscesses due to hematogenous SMG infection are rare but can be observed even in healthy patients. In such cases, physicians should consider the existence of primary lesions that allow penetration of the SMG.
Fatal cardiac injury sustained from an air gun: Case report with review of the literature
Authors: Timothy Guenther, Sarah Chen, Curtis Wozniak, David Leshikar
Journal: Int J Surg Case Rep (2020)
Keywords: air gun injury, cardiac tamponade, pellet gun injury, penetrating cardiac injury
MeSH terms: Case Reports

Introduction:
Traditionally promoted as "toy guns," air guns have long been used by children and lack many regulatory guidelines compared to conventional firearms. However these weapons possess serious lethal potential and have led to numerous injuries and deaths.
Presentation of case:
We describe a 21 year old man who sustained a penetrating cardiac wound from a pellet gun that led to cardiac tamponade and death. Post-mortem examination showed the pellet had penetrated the left ventricle and anterior esophagus with subsequent intraluminal migration into the stomach.
Discussion:
Review of the literature identified 39 other cases of penetrating cardiac injuries from air guns. Sternotomy was the most frequently used surgical approach and the right and left ventricles were the most commonly affected chambers. Bullet embolization was the most frequently reported complication. Including our case, five deaths related to penetrating cardiac injury from air guns were identified.
Conclusions:
This report highlights the seriousness of air guns and demonstrates a unique intra-thoracic injury.
Congenital malformation of fetus in a pregnancy following spontaneous ovulation in a case of premature ovarian failure
Authors: Priya Selvaraj, Kamala Selvaraj, Megha Agrawal, Gunjan Singh
Journal: J Hum Reprod Sci (2010)
Keywords: congenital malformation, donor oocyte program, genetic screening, karyotyping, premature ovarian failure, spontaneous ovulation
MeSH terms: Case Reports

Premature ovarian failure (POF), that is, amenorrhea before 40 years of age can be attributed to a variety of etiologies. Approximately 1% of women before 30 years are diagnosed with POF. Spontaneous ovulation leading to pregnancy in POF is even a rarer entity. We report a case where congenital malformations were diagnosed in a fetus following spontaneous ovulation in a case of POF. A 33-year-old woman presented to our center with primary infertility. On complete work up, she was diagnosed with POF and conceived with hormone replacement therapy and donor oocyte program. She delivered a healthy female baby through caesarean section. The patient reviewed later with amenorrhea of 40 days and pregnancy was confirmed. However, during antenatal follow-up congenital anomalies in fetus were diagnosed sonographically. The decision for termination of pregnancy was taken. To conclude, we recommend large-scale retrospective analysis that would define medical guidelines in cases of pregnancy following spontaneous ovulation in POF.
Riedel's Thyroiditis: Pitfalls in Diagnosis and Subsequent Complications
Authors: R Pandev, M Khan, V Ratheesh
Journal: Case Rep Endocrinol (2023)
MeSH terms: Case Reports

Riedel's thyroiditis is a rare disease of chronic inflammation with fibrotic infiltration of the thyroid gland and its surrounding vital structures. Due to its low incidence, there are often delays in diagnosis as it is commonly mistaken for other thyroid diseases. We report the case of a 34-year-old female patient who presented with a firm, enlarged mass in the neck, compression symptoms, and hypothyroidism. Lab tests showed elevated A-TG (thyroglobulin antibodies) and A-TPO (thyroid peroxidase antibodies) levels. Based on the disease presentation and supporting lab findings, the patient was misdiagnosed with Hashimoto's thyroiditis and treated accordingly. Yet the patient's symptoms grew progressively worse. She was discovered to have severe tracheal compression and bilateral RLN (recurrent laryngeal nerve) palsy. Tracheotomy became a necessary surgical intervention after the development of respiratory failure, but this procedure was complicated by the development of an intraoperative pneumothorax. After an open biopsy, histology revealed Riedel's thyroiditis. A new treatment was introduced, with which the patient's condition improved. However, she continued to suffer from the open tracheocutaneous fistula left by the tracheostomy, which adversely affected her everyday life. A follow-up operation was performed to close the fistula. In this case report, we discuss the consequences of misdiagnosing the patient and delaying the appropriate treatment for her disease.