OpenMed/multicare-articles huggingface dataset:
Case report: Dermatophytic pseudomycetoma in a domestic Korean short hair cat treated with intralesional injection of amphotericin B and oral terbinafine administration
Authors: Jaechun Cho, Chul Park, Jinho Park, Ji-Seon Yoon
Journal: Front Vet Sci (2024)
Keywords: microsporum canis, amphotericin b, cat, dermatophytosis, intralesional injection, pseudomycetoma
MeSH terms: Case Reports

Dermatophytic pseudomycetoma (DPM), which is a deeper dermal and/or subcutaneous infection of dermatophytes, has been rarely reported in Domestic Korean Short Hair Cats. A 3-year-old, spayed female, domestic Korean Short Hair Cat presented with a history of crusts, nodules, and pruritus for 1 year. At the initial presentation, multifocal ulcerative nodules covered with yellowish grains were noted on her ventral thorax, abdomen, flank, and left hindlimb. Cytology of ulcerative nodules revealed degenerative neutrophils, macrophages, multinucleated giant cells, and hyphae. Histological examination of nodules revealed pyogranulomatous dermatitis with fungal plaques, and Microsporum canis and Staphylococcus aureus were identified in the culture. Therefore, the cat was diagnosed with DPM with secondary pyoderma. Oral itraconazole (10 mg/kg, once a day) was administered, but no significant improvement was observed. Therefore, intralesional (IL) injection of amphotericin B (0.6 mg/nodule) and oral administration of terbinafine (30 mg/kg, twice a day) were administered to the cat. With these medications, ulceration and the number and size of nodules decreased significantly, although large dome-shaped nodules remained. Skin lesions were treated with oral terbinafine and itraconazole administration for 5 months. However, after 6 months, recurrence of multifocal ulcerative nodules was observed, and the cat died 10 months after initial presentation. In this case, IL amphotericin B and oral terbinafine administration were partially effective in DPM treatment, suggesting that this may be an option for DPM treatment. Further studies to determine dose and frequency of IL amphotericin B in the management of DPM are warranted.
Infantile Monosialoganglioside2 (GM2) Gangliosidosis With Concurrent Bronchopneumonia: An Extraordinary Case of Tay-Sachs Disease
Authors: Han Grezenko, Shadi S Al-Deir, Filagot D Eshete, Nuzhat Faran, Ciara S Mimms, Muhammad Ibrahim
Journal: Cureus (2024)
Keywords: bronchopneumonia, consanguinity, enzyme replacement therapy, genetic counseling, gm2 gangliosidosis, hexosaminidase a deficiency, neurodegenerative disorders, rare pediatric presentation, seizure management, tay-sachs disease
MeSH terms: Case Reports

Tay-Sachs disease (TSD) is a rare, fatal neurodegenerative disorder characterized by the deficiency of the enzyme hexosaminidase-A (Hex A), which results in the accumulation of monosialoganglioside2 (GM2) ganglioside within nerve cells, predominantly affecting individuals of Ashkenazi Jewish descent. We report a remarkable case of a three-year-old South Asian male with infantile GM2 gangliosidosis, compounded by bronchopneumonia, a rarely documented complication in Tay-Sachs patients. The patient presented with recurrent seizures, fever, cough, and developmental delay. Confirmation of the diagnosis was obtained through reduced Hex A enzyme activity, corroborated by imaging and blood and urine analyses. Family history was significant for consanguinity and similar sibling fatalities. Despite the progressive nature of the disease, symptomatic management, including antiepileptic drugs, antibiotic therapy, and supportive care, led to an improvement in clinical condition, though ongoing monitoring remains essential. In this case, the coexistence of bronchopneumonia with Tay-Sachs disease is unusual, reflecting the necessity for this case report. The patient's response highlights the potential for symptomatic management, the importance of genetic counseling, and the imperative for research into gene and enzyme replacement therapies. The uniqueness of this case provides novel insights into the disease's spectrum, enhancing awareness, encouraging early diagnosis, and refining care strategies for Tay-Sachs disease, aligning with the broader goals of improving patient outcomes and advancing medical research.
Expanding the Spectrum of Diabetic Striatopathy: Insights from a Case of Hyperglycemia-Induced Propriospinal Myoclonus
Authors: Debaleena Mukherjee, Subhankar Chatterjee, Peyalee Sarkar, Ritwik Ghosh, Shambaditya Das, Biman Kanti Ray, Alak Pandit, Julián Benito-León, Souvik Dubey
Journal: Tremor Other Hyperkinet Mov (N Y) (2023)
Keywords: diabetes mellitus, propriospinal myoclonus, diabetic striatopathy, movement disorders
MeSH terms: Diabetes Mellitus, Dyskinesias / diagnostic imaging, Dyskinesias / etiology, Hyperglycemia / complications, Movement Disorders, Myoclonus / diagnostic imaging, Myoclonus / etiology, Case Reports, Video-Audio Media, Blood Glucose, Female, Humans, Middle Aged, Blood Glucose

This video abstract delves into the expanded definition of diabetic striatopathy, linked initially to hyperglycemia-induced choreoballism and striatal hyperintensity on magnetic resonance imaging, but now recognized to encompass a broader range of acute onset, non-choreoballistic movement disorders in diabetes mellitus, including tremors, hemifacial spasm, parkinsonism, different types of myoclonus, dystonia, restless leg syndrome, ataxia, and dyskinesias. We report the case of a 45-year-old female patient with type-2 diabetes mellitus who developed propriospinal myoclonus, characterized by painless, involuntary jerky movements of the bilateral lower limbs in a supine position after admission for suspected rhino-orbital mucormycosis. The abnormal movements resolved entirely following the control of her blood glucose levels, suggesting a direct correlation between hyperglycemia and the clinical picture. This case highlights the importance of considering a wide range of differential diagnoses for abnormal lower limb movements in diabetic patients, emphasizing the need for accurate identification of movement semiology, routine bedside capillary blood glucose checks, and prompt hyperglycemia management to resolve such movement disorders effectively.
Giant Cell Tumor of the Frontal Bone: A Rare Case Report and Review of Literature
Authors: Mohammed Ar Abdellatif, Karam Rabi, Ahmed T Ghanem, Ahmed Dawoud, Izzeddin A Bakri
Journal: Cureus (2024)
Keywords: brain ct scan, frontal headache, giant cell tumor of bone, neurosurgery, new technologies in neurosurgery, skull
MeSH terms: Case Reports

Giant cell tumors (GCTs), typically benign, predominantly manifest in individuals aged 20-40, with the most common locations being the metaphysis or epiphysis of the femur or tibia. Infrequently, they may occur in the skull. Despite their benign nature, these tumors can exhibit aggressive behavior and have the potential to metastasize. In the case at hand, a 20-year-old female presented to the hospital with a progressively enlarging right frontal swelling over the preceding months. The patient reported intermittent headaches, alleviated by analgesics, and exhibited a normal neurological examination along with a Glasgow Coma Scale (GCS) score of 15 out of 15. Imaging revealed an expansive soft tissue mass in the right frontal bone involving both inner and outer tables. Surgical intervention was pursued through a right frontal incision followed by tumor excision. Histopathological examination of the specimen confirmed the presence of a GCT. The limited existing literature on this topic highlights the need for further research and insights into effective strategies. This case contributes to addressing this gap in knowledge, offering valuable information to enhance our understanding of the challenges associated with similar rare cases and improve patient outcomes.
Aortic Regurgitation After Right Coronary Cusp Injury During Percutaneous Coronary Intervention
Authors: Taylor Bowman, Donal O'Donoghue, Jose L Diz Ferre, Leonardo A Marquez Roa, Richard Hofstra, Sabry Ayad
Journal: Cureus (2024)
Keywords: iatrogenic aortic regurgitation, left heart catheterization, right coronary cusp injury, surgical aortic valve replacement (savr), transesophageal echocardiogram (tee)
MeSH terms: Case Reports

Injury of a coronary cusp of the aortic valve is a rare complication that can occur during coronary angiography. It usually occurs from multiple attempts with different catheters to access the ostia of the right coronary artery, but it has also occurred accessing the ostia of the left coronary artery. We present the case of a patient who underwent coronary angiography with suspected coronary cusp injury that remained asymptomatic but was found to have severe aortic regurgitation during coronary artery bypass graft surgery (CABG) one week later, requiring an aortic valve replacement.
Pediatric discordant lymphoma with classic Hodgkin lymphoma in cervical lymph nodes and high-grade B-cell non-Hodgkin lymphoma in bone marrow: a case report from Pakistan
Authors: Namrita Rai, Zeenat Amna Azhar, Neelum Tahir Kheli, Fozia Lateef, Omer Javed, Muhammad Rafie Raza
Journal: Ecancermedicalscience (2024)
Keywords: hodgkin, pakistan, cancer, child, discordant, lymphoma, non-hodgkin, pediatric
MeSH terms: Case Reports

Discordant lymphoma (DL) is an uncommon condition in which two or more histologically different types of lymphomas are present at distinct anatomical sites in the same patient. Here, we report a case of a pediatric patient under 10 years old presenting with symptoms of general sickness with cervical lymphadenopathy, abdominal distension and an abdominal mass. Upon conducting investigations, classic Hodgkin lymphoma (CHL) was detected in the cervical lymph nodes, and high-grade B-cell non-Hodgkin lymphoma was detected in the bone marrow and abdominal mass. The patient was therefore diagnosed with DL. The boy was initially diagnosed with CHL but proceeded to have aggressive disease progression, due to which further workup was done. In the past, literature reports have been published for adult cases of DL, and currently, research is being conducted to formulate treatment protocols for it. However pediatric cases of DL remain widely undiscussed. Since we are dealing with a rare or widely underreported condition, we found it significant to elaborate on its clinical presentation, treatment plan, complications and prognosis.
Case report: Abscesses in children caused by invasive group A Streptococcus
Authors: Danchun Guo, Shuting Zhuang, Qinghua Lu, Yunsheng Chen, Qing Meng, Lifang Sun, Yuejie Zheng, Wenjian Wang, Dingle Yu
Journal: Front Med (Lausanne) (2024)
Keywords: abscess, antibiotics, child, group a streptococcus, resistance
MeSH terms: Case Reports

Streptococcus is one of the common pathogens of suppurative infections. Invasive group A Streptococcus (iGAS) infections often develop from skin or soft tissue infections, and streptococcal toxic shock syndrome is considered the main cause of death in Chinese children with iGAS infectious disease. However, soft tissue infections caused by iGAS infections, especially the formation of abscesses, are relatively rare. A retrospective study was conducted, and pediatric in-patients who were diagnosed with an iGAS infection identified by cultures from normally sterile sites and treated in a tertiary hospital during 2016-2018 were included. A total of 14 patients were identified, which included 10 boys and four girls. The patients had an age range from 3 months to 10 years and were diagnosed with soft tissue infections and a formation of abscesses caused by iGAS infections. The most common sites of infections were the lower limbs. In five patients, the abscess was accompanied by fever, and the local soft tissue showed redness, swelling, tenderness, and an elevated skin temperature. Laboratory findings included an increased white blood cell (WBC) count in 12 patients, an increased C reactive protein (CRP) level in seven patients, and an increased erythrocyte sedimentation rate (ESR) in 10 patients. No patients had an elevated procalcitonin level. For all 14 patients, we performed puncture and drainage of abscesses, and cultured GAS from the drainage fluid. All children also received antibiotic treatment. During 2 months of follow-up, the patients' condition remained stable and no evidence of kidney or heart damage was observed. For pediatric patients with abscesses, early diagnosis, prompt treatment with incision and drainage, and immediate culture of the drainage fluid are important. Upon confirmation of an iGAS infection, β-lactam antibiotics should be given to provide effective treatment, and in some patients with poor therapeutic outcomes, the use of vancomycin as an alternative can achieve the desired results.
Dynamic changes in tumor profiling reveal intra- and inter-tumoral heterogeneity focused on an uncharacterized HER2 mutation: a case report of a young breast cancer patient
Authors: Dörthe Schaffrin-Nabe, Anke Josten-Nabe, Andrea Tannapfel, Waldemar Uhl, Marietta Garmer, Razelle Kurzrock, Timothy Crook, Sewanti Limaye, Stefan Schuster, Darshana Patil, Merle Schaffrin, Kefah Mokbel, Rudolf Voigtmann
Journal: Front Oncol (2024)
Keywords: extensive tumor profiling, metastatic breast cancer, personalized therapy, precision oncology, treatment strategies
MeSH terms: Case Reports

Despite multiple recent advances in systemic therapy for metastatic breast cancer, cases which display suboptimal response to guideline-driven treatment are frequently seen in the clinic. Effective options for such patients are limited, particularly in later line of therapy, and selection of optimal treatment options is essentially empirical and based largely on considerations of previous regimens received. Comprehensive cancer profiling includes detection of genetic alterations in tissue and circulating tumor DNA (ctDNA), immunohistochemistry (IHC) from re-biopsied metastatic disease, circulating tumor cells (CTCs), gene expression analysis and pharmacogenomics. The advent of this methodology and application to metastatic breast cancer, facilitates a more scientifically informed approach to identification of optimal systemic therapy approaches independent of the restrictions implied by clinical guidelines. Here we describe a case of metastatic breast cancer where consecutive comprehensive tumor profiling reveals ongoing tumor evolution, guiding the identification of novel effective therapeutic strategies.
Case Report: AMSAN variant of GBS complicating immediate postpartum period with severe dysautonomia leading to Posterior Reversible Encephalopathy Syndrome
Authors: Koushik Ramachandra, Hitha Almengada, Meghana Deepak Madi
Journal: F1000Res (2024)
Keywords: acute motor- sensory axonal neuropathy (amsan), guillain barre syndrome (gbs), intrauterine death, plasma exchange, post partum, posterior reversible encephalopathy syndrome (pres)
MeSH terms: Guillain-Barre Syndrome / complications, Guillain-Barre Syndrome / diagnosis, Posterior Leukoencephalopathy Syndrome / complications, Posterior Leukoencephalopathy Syndrome / diagnostic imaging, Postpartum Period, Case Reports, Adult, Female, Humans, Magnetic Resonance Imaging, Pregnancy, Primary Dysautonomias, Young Adult

A 20's primiparous woman, following spontaneous expulsion of intrauterine death of the fetus at 30 weeks of gestation, presented on post-partum day 8 with acute onset flaccid quadriparesis and breathing difficulty, which had rapidly progressed to involve the legs on day 3 up to her upper limbs on post-partum day 5. Following examination, Guillain Barre Syndrome (GBS) with ascending diaphragmatic involvement was diagnosed, and plasma exchange was initiated. She developed raised blood pressure, headache, sudden onset visual loss with 2 episodes of generalized seizures on post-partum day 14. Brain MRI and clinical suspicion helped diagnose Posterior Reversible Encephalopathy Syndrome (PRES). The patient was treated with anticonvulsants and antihypertensive agents. She regained her vision over the next two days, completed the treatment for GBS, and made a good recovery with independence for advanced activities of daily living on follow-up.
MOG-antibody-associated transverse myelitis with the H-sign and unusual MRI enhancement: a case report and literature review
Authors: Lu Zhang, Chuan Feng, Ling He, Shi-Yu Huang, Xin-Yin Liu, Xiao Fan
Journal: Front Pediatr (2024)
Keywords: h-sign, antibody, magnetic resonance imaging, myelin oligodendrocyte glycoprotein, myelitis
MeSH terms: Review

Transverse myelitis is the second most common symptoms in myelin oligodendrocyte antibody-associated diseases (MOGAD), causing obvious clinical manifestation. T2-hyperintense lesions mainly restricted to the gray matter in the spinal cord on axial magnetic resonance imaging, produce the H-sign, which is thought to be the typical finding of MOGAD. Contrast enhancement can be observed in some cases of myelin oligodendrocyte antibody-associated transverse myelitis (MOG-TM). However, reports on the enhancement pattern associated with the H-sign are rarely seen. In this report, we describe a case of pediatric MOG-TM in which the H-sign was observed without enhancement, while the surrounding white matter exhibited enhancement. This pattern contradicts the previously observed gray matter involvement. Then we reviewed the literatures of myelin oligodendrocyte antibody-positive myelitis to focus on the neuroimaging features and discuss the implications of our finding.
Doing-together with words: the sequential unfolding of a moment of meeting in a psychoanalytic therapy session
Authors: Marcos Herrera, Andrea Ugarte, Gabriela Vásquez-Torres, Kene M Durand, Miguel Sánchez
Journal: Front Psychol (2023)
Keywords: conversation analysis, linguistic pragmatics, moments of meeting, psychoanalysis, psychotherapy interaction, therapeutic relationship, transformation of relation, transformative sequence

Changes in psychoanalytic therapy have been traditionally attributed to self-knowledge (insight) in the client, provided by the therapist's interpretations. In recent years there has been growing realization that such changes can also be the consequence of the development of new forms of relatedness through client-therapist interaction, particularly through special intersubjective moments called moments of meeting. Drawing on the methods and findings of Conversation Analysis about the sequential organization of psychotherapeutic interaction, this single-case study examines the unfolding of a moment of meeting in the final session of a brief psychoanalytic therapy in Peru (in Spanish) with a female client victim of domestic violence. Our analysis shows that the moment of meeting, which resolves a challenge to the intersubjective relationship posed by a now moment, comes about interactionally through a sequentially accomplished shared practice of co-animation. In this sequence the client, who had previously assumed a passive role, exercises her own agency to assume an active role, which the therapist ratifies through his response. In this way, a momentary but significant transformation in the here-and-now relationship between client and therapist occurs. Thus, our analysis contributes to the understanding of how a transformation of relation-the transitory emergence of a new form of relatedness-can take place in and through sequentially organized talk and action in psychotherapy. Our study also sheds light on the role of language in moments of meeting, as the moment of meeting in our segment does not occur in parallel with the exchange of linguistic utterances between client and therapist, but through the exchange of such linguistic utterances and through the sequence of actions carried out by that exchange. In this way, the sequential doing-together with words leads to a moment of meeting, bringing about change, at least momentarily, in the implicit ways-of-being-with-others of the client.
Case report: Metastatic BRAF V600E-mutated adult Wilms' tumor with robust response to BRAF/MEK inhibitor therapy
Authors: Matthew R Kroll, Cherry Au, Jessica Slostad, Trevor N Christ, Sam G Papas, Alan Tan
Journal: Front Oncol (2024)
Keywords: braf v600e, braf/mek inhibition, wilms, precision oncology, rare tumors
MeSH terms: Case Reports

Nephroblastoma or Wilms' tumor (WT) is the most common pediatric renal malignancy but rare in adults. Treatment protocols for adults are typically extrapolated from pediatric guidelines, but there are no standard guidelines for adults due to the rarity of the disease. However, next-generation sequencing has led to new therapeutic options for adult WT patients. We present the first case to our knowledge of a recurrent adult WT treated with dual BRAF/MEK-targeted therapy, which showed initial robust clinical response and was well tolerated.
Severe right ventricular infarction due to iatrogenic aortocoronary dissection successfully treated by surgical repair and extracorporeal membrane oxygenation
Authors: Shunya Ono, Shuhei Kawamoto, Toshiya Fukushima, Motoharu Shimozawa, Retsu Tateishi, Fumiya Haba, Yoshinori Nakahara, Takeyuki Kanemura
Journal: J Surg Case Rep (2024)
Keywords: extracorporeal membrane oxygenation, iatrogenic aortocoronary dissection, right ventricular infarction
MeSH terms: Case Reports

Iatrogenic aortocoronary dissection (IACD) is a rare but potentially fatal complication of percutaneous coronary intervention or coronary angiography (CAG). In particular, if the condition of the patient is complicated by cardiogenic shock and right ventricular (RV) dysfunction, the mortality rate is high. Herein, we report the case of an 85-year-old woman with IACD who underwent elective CAG of the right coronary artery complicated with cardiogenic shock due to RV infarction. After prompt surgical repair and postoperative extracorporeal membrane oxygenation, the postoperative course was uneventful and the patient was discharged to a rehabilitation facility.