OpenMed/multicare-articles huggingface dataset:
Secondary breast cancer after Hodgkin lymphoma: a case report and literature review
Authors: Joaira Bakkach, Mohamed Mansouri, Ali Loudiyi, Naima Ghailani Nourouti, Amina Barakat, Mohcine Bennani Mechita
Journal: Ecancermedicalscience (2018)
Keywords: hodgkin lymphoma, cancer survivorship, radiotherapy, secondary breast cancer
MeSH terms: Case Reports

The occurrence of secondary breast cancers in women previously exposed to chest irradiation for Hodgkin lymphoma (HL) is considered as a major issue for the quality of life of these long-term survivors as well as a challenge for clinical management. This study reports a case of a woman treated for HL at the age of 24 years, who developed breast cancer after an interval of 20 years. This case highlights once again the importance of awareness among HL survivors about their increased breast cancer risk and re-launches the debate about the efficacy of adoption of breast screening guidelines.
Isolated schwannoma of the urinary bladder: a case report and review of the literature
Authors: Hamid Nasrollahi, Ali Ariafar, Faisal Ahmed, Maral Mokhtari, Ali Eslahi, Mansour Ansari, Umayir Chowdhury
Journal: Pan Afr Med J (2020)
Keywords: bladder, schwannoma, transurethral resection
MeSH terms: Neurilemmoma / diagnosis, Urinary Bladder Neoplasms / diagnosis, Case Reports, Review, Adult, Cystectomy, Female, Humans, Neurilemmoma / pathology, Neurilemmoma / surgery, Urinary Bladder Neoplasms / pathology, Urinary Bladder Neoplasms / surgery

The urinary bladder schwannoma is an extremely rare primary urologic tumor. Schwannoma arises from the Schwann's cells in the nerve sheaths and is almost associated with von Recklinghausen's disease. We report a case of schwannoma in a 35-year old female who presented with urinary frequency for 2 months with absence of evidence of von Recklinghausen disease and successfully treated with transurethral resection of bladder lesion (TUR_B). To the best of our knowledge, this represents only the 10th case of benign schwannoma of the urinary bladder in a patient without von Recklinghausen disease. We report a case of an isolated schwannoma of the urinary bladder, and also searched the English literature as we had access to bladder schwannoma.
BLNK mutation associated with T-cell LGL leukemia and autoimmune diseases: Case report in hematology
Authors: Guillemette Fouquet, Julien Rossignol, Laure Ricard, Flavia Guillem, Lucile Couronné, Vahid Asnafi, Manon Vavasseur, Mélanie Parisot, Nicolas Garcelon, Frédéric Rieux-Laucat, Arsène Mekinian, Olivier Hermine
Journal: Front Med (Lausanne) (2022)
Keywords: b-cell linker, autoimmune diseases, case report, large granular lymphocyte leukemia, regulatory b-cells, regulatory t-cells (t reg)
MeSH terms: Case Reports

We present the case of a female patient with a heterozygous somatic BLNK mutation, a T-cell LGL (large granular lymphocyte) leukemia, and multiple autoimmune diseases. Although this mutation seems uncommon especially in this kind of clinical observation, it could represent a new mechanism for autoimmune diseases associated with LGL leukemia. The patient developed several autoimmune diseases: pure red blood cell apalsia, thyroiditis, oophoritis, and alopecia areata. She also presented a T-cell LGL leukemia which required treatment with corticosteroids and cyclophosphamide, with good efficacy. Interestingly, she had no notable infectious history. The erythroblastopenia also resolved, the alopecia evolves by flare-ups, and the patient is still under hormonal supplementation for thyroiditis and oophoritis. We wanted to try to understand the unusual clinical picture presented by this patient. We therefore performed whole-genome sequencing, identifying a heterozygous somatic BLNK mutation. Her total gamma globulin level was slightly decreased. Regarding the lymphocyte subpopulations, she presented a B-cell deficiency with increased autoreactive B-cells and a CD4+ and Treg deficiency. This B-cell deficiency persisted after complete remission of erythroblastopenia and LGL leukemia. We propose that the persistent B-cell deficiency linked to the BLNK mutation can explain her clinical phenotype.
Pulmonary Hypertension due to a Pulmonary Artery Leiomyosarcoma: A Case Report
Authors: Seyyed Hassan Adeli, Bardia Nemati, Mahboubeh Jandaghi, Mohammad Mahdi Riahi, Fatemeh Hosseinzadeh, Fatemeh Salarvand
Journal: Case Rep Pulmonol (2013)

Background. Primary pulmonary artery sarcomas are very rare and their histologic type, called leiomyosarcoma, is even rarer. Case Report. A 64-year-old woman presented with progressive weakness, fatigue, malaise, and dyspnea, and a marked elevation of pulmonary artery pressure was admitted. She was initially diagnosed with chronic pulmonary thromboembolism and chest computed tomography (CT) scan revealed that lobulated heterogeneous left hilar mass extended to precarinal and subcarinal space. MRI demonstrated a polypoid lesion at trunk with extension to left main pulmonary artery and its first branch. She was operated, a yellowish-shiny solid mass in pulmonary trunk was seen intraoperatively, and pulmonary endarterectomy was performed. Her tumor was pathologically diagnosed as pulmonary artery leiomyosarcoma. She died 3 months later after one chemotherapy course. Conclusion. Initially, the patient underwent surgery due to pulmonary embolism but, during the operation, the observed mass increased the probability of pulmonary artery neoplasm. Clinicians must consider pulmonary artery sarcoma when making the differential diagnosis for patients with pulmonary arteries masses. In addition to clinical prediction scores and CT and MRI findings to identify the patients with pulmonary artery sarcoma, PET scanning is the diagnosis of choice in differentiating embolism and neoplasm and is strongly recommended in these patients.
Adrenocortical adenoma in a Sudanese girl with Beckwith-Wiedemann syndrome
Authors: Eman Abdalla Ali Elnaw, Awad Rhmattalla Abdalla, Mohamed Ahmed Abdullah
Journal: Int J Pediatr Endocrinol (2019)
Keywords: adrenocortical adenoma, beckwith-wiedemann, resource-limited setting, virilization
MeSH terms: Case Reports

Background:
We report a case of right adrenocortical adenoma in a girl with features suggestive of Beckwith Wiedemann syndrome to show the importance of tumor surveillance in patients with Beckwith Wiedemann syndrome.
Case presentation:
A 4-years-old female with features suggestive of Beckwith-Wiedemann syndrome presented with 9 months history of virilization. Hormonal investigations results showed high levels of testosterone (2.3 ng/ml, normal values 0.1-0.4 ng/ml), and DHEAS (73 ng/ml normal values 1-6 ng/ml) with normal cortisol level. Computed tomography revealed a right adrenal mass. She underwent right adrenalectomy. Histopathological examination of the resected adrenal gland showed adrenocortical adenoma. Her postoperative evaluation showed a normal testosterone level.
Conclusion:
Adrenocortical neoplasms though rare in children are well documented in Beckwith-Wiedemann syndrome patients. So tumor surveillance protocol should be employed, even in a resource-limited setting for early tumor detection and a better outcome.
Resective Surgery for Double Epileptic Foci Overlapping Anterior and Posterior Language Areas: A Case of Epilepsy With Tuberous Sclerosis Complex
Authors: Tohru Okanishi, Ayataka Fujimoto, Mitsuyo Nishimura, Keiko Niimi, Sotaro Kanai, Hideo Enoki
Journal: Front Neurol (2018)
Keywords: broca’s area, wernicke’s area, awake surgery, epilepsy surgery, language area, language mapping, tuberous sclerosis complex
MeSH terms: Case Reports

Tuberous sclerosis complex is a genetic systematic disorder characterized by hamartomas in multiple organs. Cortical tubers, the hamartomas in the cerebrum, cause multifocal refractory seizures. In certain cases, epileptic foci potentially involve language areas, and hence, extra- and intraoperative cortical mapping can help identify anterior and posterior areas, thus avoiding postsurgical language impairment. We report on a 21-year-old female with tuberous sclerosis complex experiencing refractory partial seizures due to two epileptic foci in the left hemisphere overlapping anterior and posterior language areas. To completely evaluate both language areas, we performed stepwise resections beginning from the anterior to the posterior epileptic focus. Although the patient presented with expressive aphasia following anterior resection, it was possible to conduct language tests during every resection. Postoperatively, she presented with expressive aphasia, comprehension deficits, left-right disorientations, and arithmetic deficits. The language dysfunctions almost disappeared at 5 weeks after the surgery and were completely resolved at 6 months after surgery. At postoperative 9 months, she was free from seizures.
Abdominal Pain in the Female Patient: A Case of Concurrent Acute Appendicitis and Ruptured Endometrioma
Authors: Martine A Louis, Amanda R Doubleday, Elizabeth Lin, Ji Yoon Baek, Alda Andoni, Xiao Hui Wang
Journal: Case Rep Surg (2016)
MeSH terms: Case Reports

General surgeons are often asked to evaluate acute abdominal pain which has an expanded differential diagnosis in women of childbearing age. Acute appendicitis accounts for many surgical emergencies as a common cause of nongynecologic pelvic pain. In some rare instances, acute appendicitis has been shown to occur simultaneously with a variety of gynecologic diseases. We report a case of concurrent acute appendicitis and ruptured ovarian endometrioma.
Massive Acquired Renal Cysts Presenting with Bowel Obstruction-Like Symptoms
Authors: Chutikarn Teparak, Weeratian Tawanwongsri
Journal: Case Rep Med (2022)
MeSH terms: Case Reports

Acquired cystic kidney disease (ACKD) is rarely massive in size. The great majority is asymptomatic and incidentally found on imaging studies for unrelated causes. We reported a case of an 85-year-old male with bilateral multiple huge acquired renal infected cysts, initially presenting with bowel obstruction-like symptoms. The computed tomography (CT) scan later aided in an accurate diagnosis. Symptomatic huge ACKD has, to our knowledge, scarcely been described. In addition, retroperitoneal lesions resulting in abdominal pain remain unusual and underrecognized in general practice.
Pathologic fractures: a neglected clinical feature of parathyroid adenoma
Authors: Hassan Abshirini, Iran Rashidi, Nader Saki
Journal: Case Rep Med (2010)
MeSH terms: Case Reports

The pattern of clinical presentation of primary hyperparathyroidism (pHPT) has changed dramatically from a severe disease to an asymptomatic condition in Western countries. The story is completely different in Eastern countries. Bone and joint related sign and symptoms like bone pain and multiple fractures are common in these patients. Imaging and nuclear medicine studies will be helpful specially in patient who candidate for surgical removal of the abnormal parathyroid gland. Here, we present a 48-year-old man with multiple typical fractures in long bones and a single adenoma in his right inferior parathyroid gland. pHPT is a severe, symptomatic disease with serious complications and high morbidity in Iran. Advanced skeletal disease is the most common pattern of presentation.
Sclerosing angiomatoid nodular transformation (SANT) of spleen mimicking a splenic abscess: Case report and review of the literature
Authors: Massimo Capaldi, Pietro Fransvea, Gabriele Ricci, Francesca Stella, Silvia Trombetta, Saverio Cerasari, Carlo Cataldi, Sabrina Casale, Pierluigi Marini
Journal: Int J Surg Case Rep (2019)
Keywords: abscess, sant, spleen

Introduction:
SANT of the spleen is a benign lesion that does not recur after splenectomy with unknown etiology.
Presentation of the case:
We report a case of sclerosing angiomatoid nodular transformation (SANT) of the spleen mimicking a splenic abscess in a patient with imaging studies that failed to differentiate this lesion from other splenic lesions.
Discussion:
SANT of the spleen is a rare condition, with only less than 100 cases reported in the literature. Clinically, SANT is only a kind of described pathological diagnostic conception. As in our case, these splenic lesions are often incidental findings on imaging studies performed for other reasons.
Conclusion:
The patient was treated with splenectomy, which has proved to be both diagnostic and therapeutic. Although histology can lead to the diagnosis of vascular tumor, immunohistochemistry is the only way to confirm the diagnosis.
Modified Open Suprapectoral EndoButton Tension Slide Tenodesis Technique of Long Head of Biceps with Restored Tendon Tension-Length
Authors: Jagadish Prabhu, Mohammed Khalid Faqi, Rashad Khamis Awad, Fahad Alkhalifa
Journal: Open Orthop J (2017)
Keywords: biceps rupture, eendobutton, ttendon sliding techniques/instrumentation, ttenodesis
MeSH terms: Case Reports

Background:
The vast majority of biceps tendon ruptures occurs at the proximal insertion and almost always involves the long head. There are several options for long head of biceps (LHB) tenodesis with advantage and disadvantages of each technique. We believe that the suprapectoral LHB tenodesis described in this article enables the restoration of the anatomic length-tension relation in a technically reproducible manner, when following the guidelines set forth in this article, and restores biceps contour and function adequately with a low risk of complications.
Method:
We present a case of a young man who had a sudden jerk of his flexed right elbow, while involved in water skiing sports and sustained complete rupture of proximal end of long head of biceps tendon. In this article, we describe a modified surgical technique of open supra-pectoral long head of biceps tenodesis using an EndoButton tension slide technique, reproducing an anatomic length-tension relationship.
Results:
By the end of one year, patient regained symmetrical muscle bulk, shape and contour of biceps compared to other side. There were no signs of dislodgement or loosening of the EndoButton on follow-up radiographs. He regained full muscle power in the biceps without any possible complications, such as humeral fracture, infection, or nerve injury, associated with this technique.
Conclusion:
This technique is a safe, easy to reproduce, cost-effective, less time consuming and an effective method that uses a small drill hole, conserving bone, minimizing trauma to the tendon, and decreasing postoperative complications. It does not need any special instrumentation and is suitable especially for use in centers where arthroscopy facility or training is not available.
Pleomorphic rhabdomyosarcoma infiltrating thoracic spine in a 59-year-old female patient: Case report
Authors: Matthias Spalteholz, Jens Gulow
Journal: GMS Interdiscip Plast Reconstr Surg DGPW (2017)
Keywords: en-bloc spondylectomy, pleomorphic rhabdomyosarcoma, soft tissue sarcoma, thoracic spine
MeSH terms: Case Reports

Rhabdomyosarcoma (RMS) represents a malignant tumor of skeletal muscle cells arising from rhabdomyoblasts. RMS represents the most common soft tissue sarcoma in children. In adults it is uncommon and accounts for less than 1% of all malignant solid tumors. While treatment protocols are well known for children, there is no standardized regimen in adults. This is one reason, why the outcome in adults is worse than in children. We present the case of a 59-year-old female patient with pleomorphic rhabdomyosarcoma (PRMS) infiltrating the thoracic spine. Multimodality treatment was performed including en-bloc resection, adjuvant multidrug chemotherapy and radiation beam therapy. The patient was tumor free and had no relapse within 6 month follow-up.
Comprehensive Treatments for Congenitally Missing Teeth and Generalized Diastema
Authors: Mehran Bahrami, Fariba Saleh Saber, Amirreza Hendi
Journal: Case Rep Dent (2017)
MeSH terms: Case Reports

Congenitally missing teeth and/or hypodontia is a prevalent dental anomaly. There are different treatment options available for these conditions such as space maintenance, restoring the space by resin-bonded-fixed-partial-dentures (RBFPDs), and dental implants. This study addresses the comprehensive treatments for congenitally missing tooth and diastema using interdisciplinary approaches. One patient was treated with small-diameter-implants and the other one was treated using an intraoral scanner to make digital impression and fabricating RBFPDs with CAD/CAM system. Both patients were completely satisfied.
A Well-Trained Team During Anaphylactic Shock After Rocuronium in a Patient With Aortic Stenosis: A Case Report
Authors: Tamar Macharadze, Andrew Davies, Igor Fedor
Journal: Front Med (Lausanne) (2020)
Keywords: anaphylactic shock, aortic stenosis, cardiac surgery, cardiopulmonary resuscitation, rocuronium
MeSH terms: Case Reports

A 66-year-old patient with aortic stenosis was scheduled for an aortic valve replacement and coronary artery bypass surgery. Anesthesia was induced by intravenous injection of midazolam, fentanyl, and propofol. After administration of rocuronium, he developed anaphylactic shock, which was diagnosed by clinical signs, vital parameters, and unresponsiveness to the usual vasopressors. After 30 min of cardiopulmonary resuscitation, the patient survived without any neurological deficits. This case is a reminder that early recognition and treatment of intraoperative hypersensitivity reactions are imperative. Anesthetists should also receive simulation training to achieve an adequate experience in a safe environment. With a well-trained team, it is possible to save the life of patients with aortic stenosis.
Surprising Diagnosis of Myxedema Crisis In-Patient Who Presented With Altered Sensorium
Authors: Gajanan N Umalkar, Gajanan Chavan, Charuta Gadkari, Mayur B Wanjari
Journal: Cureus (2023)
Keywords: cold intolerance, constipation, fatigue, hypothyroidism, myxedema crisis, weight gain
MeSH terms: Case Reports

Hypothyroidism, a disorder of decreased thyroid hormone secretion diagnosed by increased thyroid stimulating hormone (TSH) and low free triiodothyronine (FT3) and free thyroxine (FT4) levels, is classified as primary and secondary hypothyroidism, depending on the pathology. Raised TSH levels are associated with primary hypothyroidism, while decreased levels of TSH are seen in secondary hypothyroidism. With the easy availability of diagnostic tests, hypothyroidism can be detected and managed early but can be life-threatening if not treated within time. Manifestations of hypothyroidism are dry skin, hoarseness of voice, weight gain, constipation, cold intolerance, fatigue, and lethargy; however, the clinical presentation can differ as per age and sex and person to person. Here, we present one such case, which was brought to the emergency room with a history of altered sensorium, hypotension, and swelling over the bilateral lower limbs and face, with a surprise diagnosis of myxedema crisis. The uniqueness of this case is the omnipresent availability of early diagnosis and treatment in this era. still got a female patient with altered sensorium who was diagnosed to be a myxedema crisis which was given a lesser thought in our provisional diagnosis.
Case report: ultrasound assisted catheter directed thrombolysis of an embolic partial occlusion of the superior mesenteric artery
Authors: Simone Bongiovanni, Marco Bozzolo, Simone Amabile, Enrico Peano, Alberto Balderi
Journal: Front Radiol (2023)
Keywords: ekos, acute mesenteric ischemia, embolism, superior mesenteric artery, thrombolytic therapy, tissue plasminogen activator, ultrasound assisted catheter directed thrombolysis
MeSH terms: Case Reports

Acute mesenteric ischemia (AMI) is a severe medical condition defined by insufficient vascular supply to the small bowel through mesenteric vessels, resulting in necrosis and eventual gangrene of bowel walls. We present the case of a 64-year-old man with recrudescence of prolonged epigastric pain at rest of few hours duration, cold sweating and episodes of vomiting. A computed tomography scan of his abdomen revealed multiple filling defects in the mid-distal part of the superior mesenteric artery (SMA) and the proximal part of jejunal branches, associated with small intestine walls thickening, suggesting SMA thromboembolism and initial intestinal ischemia. Considering the absence of signs of peritonitis at the abdominal examination and the presence of multiple arterial emboli was decided to perform an endovascular treatment with ultrasound assisted catheter-directed thrombolysis with EkoSonic Endovascular System-EKOS, which resulted in complete dissolution of the multiple emboli and improved blood flow into the intestine wall. The day after the procedure the patient's pain improved significantly and 5 days after he was discharged home asymptomatic on warfarin anticoagulation. After 1 year of follow-up the patient is fine with no further episodes of mesenteric ischemia or other embolisms.
Possible Reactivation of SARS-CoV-2 in a Patient with Acute Myeloid Leukemia Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: a Case Report
Authors: Vera Dalla Via, Matthias von Rotz, Veronika Bättig, Karoline Leuzinger, Hans H Hirsch, Jakob Passweg, Georg Stüssi, Michael Medinger
Journal: SN Compr Clin Med (2021)
Keywords: acute myeloid leukemia, allogeneic hematopoietic stem cell transplantation, covid-19, sars-cov-2

Reactivation or reinfection cases of SARS-CoV-2 are known but there is scarce evidence about reactivation in immunocompromised patients. Here, we report the case of a 61-year-old male undergoing a conditioning regimen with fludarabine, cyclophosphamide, and 2-Gy total body irradiation in preparation of a haplo-identical allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acute myeloid leukemia (AML). He received the first dose of a COVID-19 vaccine 6 weeks prior allo-HSCT and was hospitalized a month prior because of a COVID-19 bilateral pneumonia. On discharge, he showed two negative SARS-CoV-2 nasopharyngeal PCR swabs as well as a high SARS-CoV-2 antibody titer. On admission for allo-HSCT, he tested negative for SARS-CoV-2 again. Conditioning with fludarabine, cyclophosphamide, and 2-Gy total body irradiation was started and the patient developed lymphopenia. During his hospital stay, he tested positive for SARS-CoV-2 in a PCR test twice but remained asymptomatic. The conditioning regimen was continued as planned. Later during his stay, the patient showed undetectable SARS-CoV-2 load four times. This case documents possible reactivation of SARS-CoV-2 and raises questions about reactivation risks among recipients of stem cell transplants and other immunocompromised patients.
Trisomy 9 mosaicism diagnosed in utero
Authors: Hironori Takahashi, Satoshi Hayashi, Yumiko Miura, Keiko Tsukamoto, Rika Kosaki, Yushi Itoh, Haruhiko Sago
Journal: Obstet Gynecol Int (2010)
MeSH terms: Case Reports

We present three cases of trisomy 9 mosaicism diagnosed by amniocentesis with ongoing pregnancies after referral to our center due to fetal abnormalities. Two cases were associated with severe fetal growth restriction (FGR), each of which resulted in an intrauterine fetal demise (IUFD) in the third trimester. The other case involved mild FGR with a congenital diaphragmatic hernia and resulted in a live birth with severe development delay. A major prenatal finding of trisomy 9 mosaicism is FGR. Fetuses with trisomy 9 mosaicism can rarely survive in the case of severe FGR.