OpenMed/multicare-articles huggingface dataset:
Case Report: Detection and quantification of tumor cells in peripheral blood and ascitic fluid from a metastatic esophageal cancer patient using the CellSearch (®) technology
Authors: Qian Tu, Marcelo De Carvalho Bittencourt, Huili Cai, Claire Bastien, Camille Lemarie-Delaunay, Marie C Bene, Gilbert C Faure
Journal: F1000Res (2014)

Analysis of ascitic fluid should help to identify and characterize malignant cells in gastrointestinal cancer. However, despite a high specificity, the sensitivity of traditional ascitic fluid cytology remains insufficient, at around 60%. Since 2004 the CellSearch (®) technology has shown its advantages in the detection of circulating tumor cells (CTCs) in peripheral blood, which can perform an accurate diagnosis and molecular analysis at the same time. To our knowledge, no previous study has explored the potential utility of this technology for the detection and quantification of tumor cells in ascitic fluid samples. Herein we report a case of metastatic esophageal adenocarcinoma in a 70-year-old man presenting with dysphagia and a large amount of fluid in the peritoneal cavity. Analysis of a peripheral blood sample and ascites sample with the CellSearch (®) technology both revealed the presence of putative tumor cells that were positive for epithelial cell adhesion molecule (EpCAM) and cytokeratin (CK) expression. This study confirmed the hematogenous dissemination of esophageal cancer by the detection of circulating tumor cells in the peripheral blood, and is the first to demonstrate that tumor cells can be identified in ascitic fluid by using CellSearch (®) technology.
COVID-19 and Cavitary Lesion in Lung
Authors: Avinash Vangara, Tara Hendrickson Rahmlow, Dedeepya Gullapalli, Sai Subramanyam Kommineni, Moeez Haroon, Subramanya Shyam Ganti
Journal: Cureus (2023)
Keywords: cavitary lung lesion, coronavirus disease 2019 (covid-19), mrsa (methicillin-resistant staphylococcus aureus), panton-valentine leukocidin (pvl), pulmonary embolism (pe)
MeSH terms: Case Reports

The clinical manifestations of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are widespread, ranging from asymptomatic to critical illness with significant morbidity and mortality. It is widely known that individuals who have viral respiratory infections are more likely to develop bacterial infections. Throughout the pandemic, despite the fact that COVID-19 was thought to be the primary cause of millions of deaths, bacterial coinfections, superinfections, and other secondary complications played a significant role in the increased mortality rate. In our case, a 76-year-old male presented to the hospital complaining of shortness of air. Polymerase chain reaction (PCR) testing was positive for COVID-19 and cavitary lesions were discovered on imaging. Treatment was guided based on the results of bronchoscopy with bronchoalveolar lavage (BAL) cultures showing methicillin-resistant Staphylococcus aureus (MRSA) and Mycobacterium gordonae. However, the case was later complicated by the development of a pulmonary embolism after anticoagulants were held due to new onset hemoptysis. Our case highlights the importance of considering bacterial coinfection in cavitary lung lesions, appropriate antimicrobial stewardship, and close follow-up for full recovery in COVID-19 infections.
Case report: Sympathetic ophthalmia after vitrectomies in a patient with Von Hippel-Lindau syndrome
Authors: Xiaonan Zhuang, Fengjuan Gao, Zhongcui Sun, Xinyi Ding, Gezhi Xu
Journal: Front Med (Lausanne) (2023)
Keywords: von hippel–lindau syndrome, autoimmune, choriocapillaris, choroid, optical coherence tomography angiography, sympathetic ophthalmia
MeSH terms: Case Reports

Background:
Sympathetic ophthalmia (SO) is a rare but sight-threatening uveitis, and most observations have been made after typical manifestations occur. This report focuses on the choroidal changes detected by multimodal imaging at the presymptomatic stage of SO, which is implicated in the early recognition of SO.
Case presentation:
A 21-year-old woman suffered from decreased vision in the right eye and was diagnosed with retinal capillary hemangioblastomas associated with Von Hippel-Lindau syndrome. The patient underwent two 23-G pars plana vitrectomies (PPVs), soon after which typical signs of SO manifested. SO resolved quickly after the oral administration of prednisone and remained stable during the follow-up of more than 1 year. The retrospective analysis revealed preexisting bilaterally increased choroidal thickness, dots of flow void on the choroid, and choriocapillaris en-face slabs in optical coherence tomography angiography (OCTA) after the first PPV, which were all reversed by corticosteroid treatment.
Conclusion:
The case report highlights the involvement of the choroid and choriocapillaris at the presymptomatic stage of SO after the first inciting event. Abnormally thickened choroid and flow void dots suggested that SO had started and an ensuing surgery would run the risk of exacerbating SO. OCTA scanning of both eyes should be ordered routinely for patients with a history of trauma or intraocular surgeries, especially before the next surgical intervention. The report also suggests that non-human leukocyte antigen gene variation may also regulate the progression of SO, which requires further laboratory investigations.
Contributions of park constructions to residents' demands of ecosystem services consumption: A case study of urban public parks in Beijing
Authors: Sibo Wang, Tingwei Li, Dongdong Li, Hong Cheng
Journal: PLoS One (2021)
MeSH terms: Ecosystem, Parks, Recreational / supply & distribution, Research Support, Non-U.S. Gov't, Beijing, Humans, Surveys and Questionnaires

Urban public parks can provide convenience for residents to get close to nature and provide places for daily ecosystem services. It is of practical and theoretical significance to choose urban public parks as the entry point to explore the changing trends and supply paths of urban residents' daily ecosystem service consumption. Based on the government 's research? of urban public parks in Beijing from 1993 to 2018, this study explores the residents' ecosystem services consumption demands and the contributions of park constructions to these demands. The results show that: (1) in the past 25 years, the frequency, duration, participation rate, and evaluation of people's daily ecosystem service consumption have increased significantly. In other words, the ecosystem services demands are increasing. (2) different constructions of a park have distinct contributions to the increasing demands of ecosystem service consumption. The contributions from constructions of the natural landscape and the infrastructure have been in decline since 1993, yet they contribute the most to the demands of residents' ecosystem services consumption until 2018. The contributions made by constructions of management and maintenance, and transportation around urban public parks have been on the rise and the significant points occurring after the 2008 Olympic Games. Our research proposes a method to determine the relation between the demands of residents' ecosystem services consumption and the contributions of park constructions to these demands, which has significant implications for optimizing the constructions of urban public parks to better meet the demands of ecosystem services consumption.
Pseudomonas aeruginosa in the Early Childhood: A Case Report
Authors: Flávia Dos Santos Moraes, Andréa Gonçalves Antonio, Marta Lua Pimentel Winz Almeida, Rodolfo de Almeida Lima Castro, Roberto Vianna
Journal: Clin Med Case Rep (2008)
Keywords: pseudomonas aeruginosa, children, dental development disorder, infection
MeSH terms: Case Reports

Pseudomonas aeruginosa is an opportunistic bacterium that usually affects immunocompromised patients, causing infections whose signals and symptoms are related to the affected organ. The patient presented in this article was infected when he was 9 months old. Such condition led to certain alterations like dental improperly positioned teeth, retained deciduous teeth, hipodonty of permanent teeth, atrophy of the upper jaw and dental crowding. Therefore, the purpose of this article is to report the case of a patient affected by Pseudomonas aeruginosa infection in the early childhood and to describe the dental development disorders as consequence of this fact.
Antineutrophil cytoplasmic antibody mediated glomerulonephritis associated with levamisole-adulterated cocaine
Authors: Zita Shiue, Bairbre McNicholas, Fionnuala Cormack, Shreeram Akilesh
Journal: Clin Nephrol Case Stud (2014)
Keywords: anca, cocaine, glomerulonephritis, levamisole
MeSH terms: Case Reports

Levamisole-adulterated cocaine has increased in prevalence over the last decade and is known to be associated with antineutrophil cytoplasmic antibodies (ANCA). Dermatologic manifestations of levamisole exposure, including cutaneous vasculitis, are widely appreciated; less is known about its effects on the kidney. We report two cases of patients with a history of cocaine abuse and levamisole-induced cutaneous vasculitis, who developed acute kidney injury in the setting of elevated ANCA titers. Renal biopsies of both revealed pauci-immune complex glomerulonephritis with diffuse crescentic disease. These cases demonstrate a rare but serious complication of long-term cocaine use.
Hereditary Hypophosphatemic Rickets with Hypercalciuria (HHRH) Presenting with Genu Valgum Deformity: Treatment with Phosphate Supplementation and Surgical Correction
Authors: Juan M Colazo, Seth A Reasoner, Ginger Holt, Marie C M Faugere, Kathryn M Dahir
Journal: Case Rep Endocrinol (2020)
MeSH terms: Case Reports

We describe a case of hereditary hypophosphatemic rickets with hypercalciuria (HHRH) in a 32-year-old female with short stature, chronic pathologic genu valgum deformity, and knee pain who was referred to endocrinology clinic after previous inconclusive workups. We present imaging spanning 10 years of untreated disease. Biochemical studies showed hypophosphatemia with undetectable fibroblast growth factor 23 (FGF23.) Renal ultrasound revealed bilateral medullary nephrocalcinosis despite no apparent hypercalciuria. Due to concern for HHRH, genetic testing was performed that determined this patient to be homozygous in the SLC34A3 gene for a previously described missense variant (c.1402C > T, p.Arg468Trp). There was no known family history of rickets. A bone biopsy with metabolic studies was performed for diagnostic and prognostic reasons. The histopathological findings along with tetracycline uptake studies were consistent with a diagnosis of HHRH. Treatment with phosphorous supplementation and surgical correction of her valgum deformity resulted in resolution of pain, but no change in bone histomorphometry.
Septic arthritis of the knee due to Pantoea agglomerans: look for the thorn
Authors: Tobias Koester, Taro Kusano, Henk Eijer, Robert Escher, Gabriel Waldegg
Journal: J Bone Jt Infect (2020)
MeSH terms: Case Reports

We report on a patient with septic arthritis of the knee with Pantoea agglomerans after a penetrating black locust thorn injury. Antibiotics alone or in combination with an arthroscopy may be insufficient for achieving source control. Accurate medical history and open debridement with a search for a thorn fragment are key to successful treatment.
Morphologic heterogeneity in carcinosarcoma of the gallbladder: report of a rare cases
Authors: Vani Krishnamurthy, Sheela Devi C Shivalingiah, Sunila Ravishankar, Gubbanna V Manjunath
Journal: Case Rep Pathol (2011)
MeSH terms: Case Reports

Carcinosarcoma is a rare tumor composed of variable proportions of carcinomatous and sarcomatous elements and comprises less than one percent of all gallbladder malignancies. In most reported cases of carcinosarcoma of gallbladder, the epithelial component is adenocarcinoma. The mesenchymal component varies from homogenous sarcoma to more heterotopic elements like malignant bone, cartilage, and other mesenchymal tissues. We report a rare case of carcinosarcoma of the gallbladder in an 83-year-old male, with the carcinomatous component represented by undifferentiated carcinoma (spindle and giant cell type with osteoclastic giant cells) and the mesenchymal component seen as foci of chondrosarcoma.
Severe TBI patients benefit from multi-modal and multi-disciplinary treatments approaches - two exemplary case reports
Authors: Kulesza Katarzyna, Tomczak Agata, Michalak Marcin
Journal: J Med Life (2019)
Keywords: craniocerebral injury, cerebrolysin, craniotomy, physical rehabilitation, psychological counseling
MeSH terms: Brain Injuries, Traumatic / therapy, Case Reports, Aged, Brain Injuries, Traumatic / diagnostic imaging, Combined Modality Therapy, Female, Humans, Male, Tomography, X-Ray Computed, Young Adult

We aim to demonstrate that multidisciplinary treatment through neurosurgical intervention, pharmacotherapy, rehabilitation, speech, and psychological therapy is the most promising treatment approach for patients with severe craniocerebral injuries. Here we describe two clinical cases who presented with an unexpectedly positive outcome as both patients regained mobility and the ability to function independently after receiving multimodal therapy.
A Case of Herpes Simplex Virus-1 Encephalitis from a Medicolegal Point of View
Authors: Alessandro Feola, Anna Mancuso, Mauro Arcangeli
Journal: Case Rep Med (2018)
MeSH terms: Case Reports

We present a case of herpes simplex virus-1 encephalitis (HSVE) and discuss the difficulty of early diagnosis and the possibility of a wrong or delayed diagnosis and treatment of this encephalitis. We show the importance of considering HSVE to pursue every case of suspicious medical liability.
Gastrointestinal bleeding due to an erosion of the superior mesenteric artery: an exceptional fatal complication of pancreatic pseudocyst
Authors: Mahdi Bouassida, Mechaal Benali, Hédi Charrada, Mossaab Ghannouchi, Fathi Chebbi, Mohamed Mongi Mighri, Mohamed Msaddak Azzouz, Hassen Touinsi, Sadok Sassi
Journal: Pan Afr Med J (2012)
Keywords: gastrointestinal bleeding, acute pancreatitis, emergency, pancreatic pseudocyst, superior mesenteric artery
MeSH terms: Gastrointestinal Hemorrhage / etiology, Mesenteric Artery, Superior, Pancreatic Pseudocyst / complications, Vascular Diseases / complications, Case Reports, Fatal Outcome, Humans, Male, Middle Aged

The erosion of a pancreatic pseudocyst into an adjacent artery is a rare and highly lethal complication of pancreatitis with reported death rates of 12% to 40%. The majority of patients had bleeding from the splenic artery, the gastroduodenal artery and the anterior pacreaticoduodenal artery. Exceptionally, some cases with bleeding from the superior mesenteric artery, or hepatic artery were reported. We report the case of a 50 year old patient having a cataclysmic upper gastrointestinal bleeding due to an erosion of the superior mesenteric artery by a pancreatic pseudocyst, and discuss contemporary methods in diagnosis and management of the condition.
Cardiac metastasis from a renal cell carcinoma
Authors: Zairi Ihsen, Mzoughi Khadija, Jnifene Zouhayer, Fennira Sana, Ben Moussa Fethia, Kammoun Sofiene, Kraiem Sondos
Journal: Pan Afr Med J (2015)
Keywords: renal cell carcinoma, cardiac metastasis, cardiac tumors, myocardium
MeSH terms: Carcinoma, Renal Cell / pathology, Heart Neoplasms / secondary, Heart Ventricles / pathology, Kidney Neoplasms / pathology, Case Reports, Aged, 80 and over, Female, Heart Neoplasms / pathology, Heart Neoplasms / surgery, Humans

Here we report a case of asymptomatic right ventricular tumor, for which surgical removal was done. Pathology reveals that the mass is a metastasis of a renal carcinoma.
Polypharmacy Leading to Priapism in HIV Patient with Schizoaffective Disorder: A CYP450 Cascade
Authors: Vinod Sharma, Aditi Sharma
Journal: Case Rep Psychiatry (2019)
MeSH terms: Case Reports

With increasing trend of polypharmacy, there are higher chances of drug-drug interactions leading to adverse effects, especially in psychiatric patients with co-morbid chronic medical problems. This case demonstrates a schizoaffective 30-year-old male on highly active antiretroviral therapy (HAART) who reported an incident of priapism potentially caused by an interaction between previously prescribed atypical antipsychotic, trazodone, norepinephrine dopamine reuptake inhibitor (NDRI), HAART, and newly added selective serotonin reuptake inhibitor (SSRI). This case emphasizes obtaining careful medication history, understanding cytochrome P450 (CYP450) enzyme and its subtypes, and discouraging polypharmacy. Clinicians must educate their patients about different sexual side effects as these can be socially stigmatizing and can further deteriorate mental health symptoms.
Bilateral posterior hip dislocation associated with right Pipkin II fracture: A case report
Authors: Abderrahim Zaizi, Hicham A Benomar, Mohammed Reda Fekhaoui, Talal Grimi, Monsef Boufettal, Mohamed S Berrada
Journal: Int J Surg Case Rep (2019)
Keywords: bilateral, femoral head, fracture, hip dislocation, pipkin

Background:
Bilateral posterior hip dislocations are very rare injury, requiring a very hight trauma energy.
Presentation of the case:
We present a case of 40-year-old male who sustained bilateral posterior hip dislocation with associated right femoral head fracture Pipkin type II following a hight energy trauma without neurovascular deficit. A prompt closed reduction was made, it was successful in lift hip but incomplete in right one, therefore, an open reduction was indicated, performed through a modified Hardinge approach permitting internal osteosynthesis with two Herbert screws.
Discussion:
Posterior hip dislocations are an orthopaedic emergency that must be reduced within 6 h to avoid sciatic nerve compression and avascular necrosis (AVN). They are most often associated with femoral head fractures commonly known as Pipkin's fractures, that need anatomic reduction and osteosynthesis through posterior approaches, rarely external or anterior approaches.
Results:
Anatomic and functional results were good at two years follow up excepting a right hip non-bridging heterotopic ossification; the patient returned to his work normally without any functional sequelae.
Addison's Disease and Dilated Cardiomyopathy: A Case Report and Review of the Literature
Authors: Viktoriya Mozolevska, Anna Schwartz, David Cheung, Bilal Shaikh, Kapil M Bhagirath, Davinder S Jassal
Journal: Case Rep Cardiol (2016)

Addison's disease is often accompanied by a number of cardiovascular manifestations. We report the case of a 30-year-old man who presented with a new onset dilated cardiomyopathy due to Addison's disease. The clinical presentation, treatment, and outcomes of this rare hormone mediated cardiac disorder are reviewed.
Rare Bilateral Adrenal Haemorrhage with Addisonian Crisis: When Risk Factors Come in Droves
Authors: Anders Boisen Jensen, Elise Durand, Vojtech Pavlicek
Journal: Case Rep Endocrinol (2020)
MeSH terms: Case Reports

Addisonian crisis is the life-threatening acute manifestation of adrenal insufficiency due to absolute or relative glucocorticoid deficiency. Adrenal haemorrhage is a rare condition of unknown incidence with the risk of adrenal insufficiency and death, not uncommonly first being diagnosed on the pathologists table. We report the case of a 68-year-old female patient with respiratory tract infection suffering acute life-threatening adrenal insufficiency caused by bilateral adrenal haemorrhages following orthopedic surgery while taking anticoagulation therapy. The patient rapidly deteriorated with hypotension, showing how important it is to consider a possible Addisonian crisis when this scenario occurs, especially with precipitating factors such as anticoagulant therapy, sepsis, or surgery.
Diagnosis of Prenatal-Onset Achondrogenesis Type II by a Multidisciplinary Assessment: A Retrospective Study of 2 Cases
Authors: Wenbo Wang, Qichang Wu, Li Sun, Xiaohong Zhong, Yasong Xu, Xiaojian Xie, Zhiying Su
Journal: Case Rep Obstet Gynecol (2019)
MeSH terms: Case Reports

Aim:
Achondrogenesis type II is a rare, lethal osteochondrodysplasia with considerable phenotypic heterogeneity. We describe our experience in diagnosing prenatal-onset achondrogenesis type II by a multidisciplinary assessment.
Methods:
Two cases of fetal achondrogenesis type II were analyzed retrospectively using prenatal ultrasound evaluation, postnatal radiographic diagnosis, and molecular genetic testing of COL2A1.
Results:
A causative mutation in the COL2A1 gene was found in both patients. Combined with postnatal radiographic examination, the final diagnosis of achondrogenesis type II was made.
Conclusion:
Our findings emphasize the importance of a multidisciplinary assessment for the definitive diagnosis of achondrogenesis type II, which is paramount for proper genetic counseling.
Extensive subcutaneous emphysema and pneumomediastinum after ecstasy ingestion
Authors: A Gungadeen, J Moor
Journal: Case Rep Otolaryngol (2013)

Objective. To present a rare case of extensive subcutaneous emphysema and spontaneous pneumomediastinum following ingestion of Ecstasy in a young adult. We also review the relevant literature and discuss how this case supplements it. Case Report. We report a case of a 19-year-old man with a history of painless neck and chest swelling, and no chest pain or breathlessness, after consuming Ecstasy tablets. Radiological imaging showed evidence of pneumomediastinum and extensive subcutaneous emphysema. The patient remained well under observation and his symptoms improved with conservative management. Conclusions. Subcutaneous emphysema and pneumomediastinum after Ecstasy ingestion is uncommon. Cases are often referred to the otolaryngologist as they can present with neck and throat symptoms. Our case showed that the severity of symptoms may not correlate with severity of the anatomical abnormality and that pneumomediastinum should be suspected in Ecstasy users who present with neck swelling despite the absence of chest symptoms. Although all cases reported so far resolved with conservative management, it is important to perform simple investigations to exclude coexisting serious pathology.
Endostar plus pembrolizumab combined with a platinum-based dual chemotherapy regime for advanced pulmonary large-cell neuroendocrine carcinoma as a first-line treatment: A case report
Authors: Sijia Zhang, Yu Xiao, Leichong Chen, Zhenyu Li, Yan Zong, Kuikui Zhu, Rui Meng
Journal: Open Life Sci (2022)
Keywords: anti-angiogenesis, chemotherapy, combination therapy, immunotherapy, pulmonary large-cell neuroendocrine carcinoma
MeSH terms: Case Reports

Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a rare and highly aggressive cancer with a very poor prognosis. The proper treatment decision and possible prognosis outcome for advanced LCNEC is always an enormous challenge due to its scarcity. Here, we presented a 59-year-old male patient with advanced LCNEC with a non-neuroendocrine immunophenotype who received endostar plus pembrolizumab combined with a platinum-based dual chemotherapy regime as a first-line treatment. At present, the patient's condition is well controlled by medication only and has a progression-free survival of more than 2 years. Adverse effects recorded for this patient during treatment courses include nausea, vomiting, II-III quality bone marrow toxicity, and PD-1 blockage-related hypothyroidism. This case report discussed the feasibility of immunotherapy, anti-angiogenesis agents, and chemotherapy as a first-line therapy in advanced LCNEC.