OpenMed/multicare-articles huggingface dataset:
Orthodontists' preferences regarding the difference of bracket bonding height between the maxillary incisors
Authors: Mauro Henrique Andrade Nascimento, Karla Magnólia Napoli Brandão, Carolina Carmo de Menezes, André Wilson Machado, Milton Santamaria-Jr
Journal: Dental Press J Orthod (2021)
MeSH terms: Incisor, Orthodontists, Esthetics, Dental, Humans, Smiling, Tooth Crown

Introduction:
The vertical position of orthodontic brackets in maxillary incisors may influence the incisal step between the anterior teeth and thereby interfere with the smile esthetics. Even so, esthetic standards have been modified over time and consistently required technical adjustments.
Objective:
This study analyzed orthodontists' preferences regarding the difference of bracket bonding height between the maxillary central incisors (MCI) and maxillary lateral incisors (MLI), and further determined whether the orthodontist sex, age and time of specialization have association to their choices.
Methods:
This study collected data through an electronic form. Study participants analyzed a clinical case in which they indicated their preference for bracket bonding height. The placement height options ranged from 3.0 mm to 5.5 mm from the incisal edge, with 0.5-mm intervals, or at the clinical crown center (CCC). The difference in the bonding height between the MCI and MLI was analyzed, considering the formation of incisal steps between these teeth.
Results:
Participants indicated that the difference in bracket bonding height between the MCI and MLI should be as follows: 0 mm (3.9%); 0.5 mm (78.3%); 1 mm (7.6%); 1.5 mm (0.2%); and CCC (9.9%). There was no statistically significant correlation between the choice for bracket bonding height and sex, age and time since specialization.
Conclusion:
Most participating orthodontists choose the 0.5-mm difference in bracket placement height between the MCI and MLI. The variables sex, age and time since specialization did not influence this choice.
Case report: Solitary fibrous tumor of the kidney with a NAB2-STAT6 fusion gene
Authors: Wen-Tong Ji, Yu Hu, Yao Wang
Journal: Front Oncol (2022)
Keywords: nab2-stat6, case report, genetic testing, immunohistochemical assay, solitary fibrous tumor
MeSH terms: Case Reports

Background:
Solitary fibrous tumor (SFT) is a rare spindle cell neoplasm that mostly originates from the pleura, and accounts for only 2% of all soft tissue tumors. Moreover, the cases of SFT of the kidney are rarely reported. Here, we report a typical case of kidney SFT, which was consistent with other reported cases. This case further expands on existing diagnostic methods of SFT and explains the importance of STAT6 mutations in SFT.
Case summary:
We report a typical case of SFT of the kidney. A 34-year-old woman presented to the urinary surgery department after physical examinations were suggestive of a urologic neoplasm. Further relevant imaging investigations suggested a renal tumor with benign behaviors. The patient was diagnosed with a kidney tumor suspected to be SFT and underwent laparoscopic radical left nephrectomy. Postoperative pathological immunohistochemical tests showed positivity for Signal Transducer and Activator of Transcription 6(STAT6), CD-34, CD-99, and Bcl-2, thus confirming the diagnosis of SFT. Combined with the results of genetic testing of the patient, the tumor was indicated to carry NGFI-A-Binding protein 2(NAB2): exon 6-STAT6: exon 16 mutation sites, which confirmed our diagnosis. The patient recovered quickly without any clinical evidence of incomplete resection. She has been followed-up for more than a year and will continue to be reviewed every three months to observe the final outcomes.
Conclusion:
Solitary fibrous tumor is difficult to differentiate from other renal tumors. CT imaging, STAT6 immunostaining and gene profiling are valid investigations to establish the diagnosis.
Case report: Multiple brain metastases of atrial myxoma: Clinical experience and literature review
Authors: Kang Ma, Dawei Zhao, Xuegang Li, Haijun Duan, Chaojun Yan, Shi Wang, Lan Zeng, Kai Xu, Ying Lai, Beike Chen, Ning Mu, Chuanyan Yang, Yulian Quan, Zhengyang Li, Xiaoming Wang, Hua Feng, Fei Li
Journal: Front Neurol (2023)
Keywords: cardiac myxoma, cerebellar hemisphere infarction, gamma knife radiosurgery, multiple brain metastasis, temozolomide
MeSH terms: Case Reports

Myxoma is the most common type of benign cardiac tumor in adults, and it has a strong tendency to embolize or metastasize to distant organs. Patients with multiple brain metastases have rarely been seen in clinics; hence, standard treatment protocols for multimyxoma metastasis in the brain have not been established. We present the case of a 47-year-old female who had convulsions in the right hand and repeated seizures. Computed tomography revealed multiple tumor sites in her brain. Craniotomy was conducted to remove the tumor sites. However, recurrent brain tumors and unexpected cerebral infarctions occurred frequently shortly after the treatment because the cardiac myxoma had not been treated due to the patient's personal concerns. The myxoma was resected by gamma knife radiosurgery, and temozolomide was given prior to cardiac surgery. There has been no evidence of tumor recurrence from the 2 years following the surgery until the present. This case highlights the importance of prioritizing cardiac lesions over cerebral lesions; if a cerebral metastasis has been found, it is likely that the cardiac myxoma is already unstable, with high rates of spread and metastasis. Therefore, it is unwise to treat metastasis sites before the cardiac myxoma. Additionally, the case suggests that gamma knife radiosurgery combined with temozolomide is effective as treatment for multiple myxoma metastasis in the brain. Compared with conventional cerebral surgery, gamma knife radiosurgery is safer, causes less bleeding, and requires a shorter time for recovery.
Development of Unilateral Peri-Lead Edema Into Large Cystic Cavitation After Deep Brain Stimulation: A Case Report
Authors: Yue Lu, Chang Qiu, Lei Chang, Bei Luo, Wenwen Dong, Wenbin Zhang, Hai-Hua Sun
Journal: Front Neurol (2022)
Keywords: parkinson's disease, deep brain stimulation, intraparenchymal cyst, peri-lead edema, subthalamic nucleus
MeSH terms: Case Reports

Background and importance:
Deep brain stimulation (DBS) has been approved to treat a variety of movement disorders, including Parkinson's disease (PD), essential tremor, and dystonia. Following the DBS surgery, some perioperative and even delayed complications due to intracranial and hardware-related events could occur, which may be life-threatening and require immediate remedial measures.
Clinical presentation:
We report a case of an older woman with advanced PD who developed the unique complication of unilateral cyst formation at the tip of the DBS electrode after undergoing bilateral placement of subthalamic nucleus DBS. After a period of controlled motor symptoms, the patient showed new neurological deficits related to right peri-lead edema. However, the new neurological symptoms regressed quickly over several days with stereotactic implantation of a puncture needle to drain the cyst fluid without removing the affected lead.
Conclusion:
The occurrence of an intraparenchymal cyst following DBS surgery is a rare but life-threatening complication that could relate to edema around the electrodes or cerebrospinal fluid tracking. Stereotactic aspiration makes the intracranial cyst regress safely and effectively and ensures that the electrode is in the optimal position of the target nucleus to achieve an effective DBS surgery.
Birt-Hogg-Dubé syndrome with c.1579_1580insA variant in a Chinese family: a case report
Authors: Shijie Tang, Chuanqi Wei, Xiaoyu Wang, Min Xiao, Fengming Luo, Lei Chen
Journal: Front Med (Lausanne) (2023)
Keywords: birt-hogg-dubé syndrome, case study, exome sequencing, genetic disease, spontaneous pneumothorax
MeSH terms: Case Reports

Birt-Hogg-Dubé (BHD) syndrome, is a rare genetic disease with heterogeneous manifestations in different populations. In this study, we reported a Chinese female BHD case and her family members with c.1579_1580insA variant in FLCN gene, who were characterized by diffused pulmonary cysts/bulla, and reviewed another five familial BHD cases in China. Based on these cases, recurrent spontaneous pneumothorax is likely to be the first symptom for BHD in Chinese patients, with particularly but not limited to c.1579_1580insA variant. Therefore, attention to the early diagnosis of BHD in China should focus on pulmonary signs, but skin or kidney lesions still can not be neglected.
A rare case of synchronous colocolic intussusception in association with Peutz-Jeghers syndrome
Authors: Om Biju Panta, Santosh Maharjan, Sujan Manandhar, Sharma Paudel, Ram Kumar Ghimire
Journal: BJR Case Rep (2016)
MeSH terms: Case Reports

Adult intussusception is rare and is almost always associated with a lead point. Polyposis syndromes are a common cause of adult intussusceptions, with polyps acting as lead points. Peutz-Jeghers syndrome is associated with benign hamartomatous polyps and mucocutaneous pigmentation. Although hamartomatous polyps are not premalignant, there is an increased risk of gastrointestinal and non-gastrointestinal malignancy, most commonly involving the small bowel. Most patients with Peutz-Jeghers syndrome with acute abdomen are diagnosed to have intussusceptions, mostly of the enteroenteric type. Colocolic intussusceptions are rare in Peutz-Jeghers syndrome. To the best of our knowledge, synchronous colocolic intussusception in association with Peutz-Jeghers syndrome has not been previously reported. Here we present a case of malignant jejunal mass and synchronous colocolic intussusceptions in a patient with Peutz-Jeghers syndrome.
Cerebral Metastasis from Breast Cancer in a Male Patient with HIV
Authors: Guilherme Lellis Badke, Guilherme Brasileiro de Aguiar, João Miguel de Almeida Silva, Aline Lariessy Campos Paiva, Eduardo Urbano da Silva, José Carlos Esteves Veiga
Journal: Case Rep Neurol Med (2015)

Context. Breast cancer (BC) in men is a rare condition, corresponding to 1% of all neoplasms in this gender. Some studies show that up to 93% of BC cases in men are advanced disease. If its occurrence constitutes an uncommon fact, the appearance of a metastasis to the central nervous system (CNS) is extremely rare. The objective of the present study is to present the case of a male patient, bearer of HIV infection, who presented with BC and later metastasis to the CNS. We also include a brief review of the literature. Case Report. We describe a case of a male patient, 59 years old, with HIV infection and a history of BC treated 4 years earlier, which progressed into headache and vertigo. Neuroimaging exams showed lesions suggestive of cerebral metastasis and a stereotaxic biopsy confirmed BC metastasis. Conclusion. Breast cancer in men with metastasis to the CNS is a rare condition and similar reports were not found in the available databases. It should be pointed out that even though rare, it should be considered among the differential diagnoses for SNC metastases in men, although HIV infection favors the appearance of some types of cancer.
Pet-related bacterial zoonotic infections: Three cases of severe infections in the immunocompromised host
Authors: E M van Wezel, E S J van der Beek, M A N Siebrecht, A J Stel, M Wouthuyzen-Bakker, N E L Meessen
Journal: IDCases (2022)
Keywords: capnocytophaga canimorsus, helicobacter canis, pasteurella multocida, pet-related infection, zoonosis
MeSH terms: Case Reports

Pets can have many positive effects on their owners. However, close contact with pets offers optimal conditions for transmission of micro-organisms. Especially immunocompromised patients are at risk for zoonotic infections. Here we describe the diagnosis, microbiology and treatment of three patients with severe zoonotic infections with Helicobacter canis, Pasteurella multocida and Capnocytophaga canimorsus. With this case report we would like to emphasize the importance of awareness for pet-related zoonotic infections in immunocompromised patients.
Lung adenocarcinoma with peculiar growth to the pulmonary artery and thrombus formation: report of a case
Authors: Taichiro Goto, Arafumi Maeshima, Ryoichi Kato
Journal: World J Surg Oncol (2012)
MeSH terms: Adenocarcinoma / pathology, Lung Neoplasms / pathology, Pulmonary Artery / pathology, Thrombosis / pathology, Case Reports, Adenocarcinoma / complications, Adenocarcinoma / surgery, Aged, 80 and over, Female, Humans, Lung Neoplasms / complications, Lung Neoplasms / surgery, Pneumonectomy, Prognosis, Pulmonary Artery / surgery, Radiography, Thoracic, Thrombosis / surgery, Tomography, X-Ray Computed

Background:
Cases of pulmonary artery masses have only rarely been reported, and the optimal type of the diagnosis and treatment is controversial.
Case presentation:
An 81-year-old woman was found to have an abnormal shadow on chest X-ray film. Computed tomography showed an irregularly bordered tumor centered in the hilar region extending from segment 6 to the middle lobe of the right lung. Pulmonary angiography showed complete occlusion of the trunk at the periphery proximal to the bifurcation of the posterior ascending branch. Based on bronchoscopic biopsy of the tumor, an adenocarcinoma was diagnosed. Middle and lower lobectomy was performed. Histopathologically, the adenocarcinoma had invaded the tunica intima of the pulmonary artery and also replaced the endothelium in the same region. Although a large thrombus was found at the vessel invasion site of the adenocarcinoma in the pulmonary artery, there were no malignant findings in the thrombus itself.
Conclusions:
This is the first reported case of radical resection of a lung cancer with invasion along the pulmonary artery wherein a benign thrombus had formed. In general, surgery would be the treatment of choice for a pulmonary artery mass.
PARP Inhibitor Olaparib Use in a BRCA1-Positive Patient With Metastatic Triple-Negative Breast Cancer, Without the Initial Use of Platinum-Based Chemotherapy, Showing Significant Rapid Near Resolution of Large Liver Metastasis While Patient Experienced Gout-Like Symptoms
Authors: Trevanne Matthews Hew, Lara Zuberi
Journal: J Investig Med High Impact Case Rep (2019)
Keywords: brca1, parp inhibitor breast cancer, gout, olaparib, triple-negative breast cancer
MeSH terms: Antineoplastic Agents / therapeutic use, Carcinoma, Papillary / drug therapy, Gout / chemically induced, Liver Neoplasms / secondary, Phthalazines / therapeutic use, Piperazines / therapeutic use, Poly(ADP-ribose) Polymerase Inhibitors / therapeutic use, Triple Negative Breast Neoplasms / drug therapy, Ubiquitin-Protein Ligases / genetics, Case Reports, Antineoplastic Agents / adverse effects, Carcinoma, Papillary / genetics, Carcinoma, Papillary / pathology, Female, Humans, Liver Neoplasms / drug therapy, Middle Aged, Phthalazines / adverse effects, Piperazines / adverse effects, Poly(ADP-ribose) Polymerase Inhibitors / adverse effects, Treatment Outcome, Triple Negative Breast Neoplasms / genetics, Triple Negative Breast Neoplasms / pathology, Antineoplastic Agents, Phthalazines, Piperazines, Poly(ADP-ribose) Polymerase Inhibitors, BRAP protein, human, Ubiquitin-Protein Ligases, olaparib

Triple-negative breast cancer (TNBC) accounts for 20% of breast cancers diagnosed worldwide. This subtype of breast cancer tends to behave more aggressively, and unlike other breast cancer subtypes, there are no standard targeted treatments for most patients. However, up to 20% of patients with TNBC harbor a breast cancer gene (BRCA) mutation, particularly in BRCA1. For patients who carry this gene mutation, this opens the door for new management options by the use of newer agents such as polyadenosine diphosphate-ribose polymerase (PARP) inhibitors in the metastatic setting. Given that this is uncommon and that PARP inhibitors have only recently received Federal Drug Administration approval, the experience with these drugs is relatively new. In this article, we present a case of a patient treated in this setting with olaparib who developed an unanticipated side effect as a result of the high efficacy of the drug.
Premature Ventricular Complex Causing Ice-Pick Headache
Authors: Selcuk Ozturk, Ertan Yetkin
Journal: Case Rep Cardiol (2017)
MeSH terms: Case Reports

Ice pick headache is a momentary, transient, repetitive headache disorder and manifests with the stabbing pains and jolts. The exact mechanism causing this disease is unknown. Premature ventricular contractions are early depolarization of the ventricular myocardium and in the absence of a structural heart disease, it is considered to be a benign disease. In this report, we describe a male patient presenting with the symptom of momentary headache attacks accompanied with instant chest pain which is associated with premature ventricular contraction.
Dysphagia, an uncommon initial presentation of sarcoidosis
Authors: Navjot Somal, Ravi Karan, Aarti Maharaj, Jeff Halperin, Brent Boodhai, Jeffrey Lipton, Daniel J Masri, Kamlesh Kumar
Journal: Respir Med Case Rep (2022)
MeSH terms: Case Reports

Sarcoidosis is a systemic inflammatory disease of unknown etiology with a myriad of clinical presentations depending on the organ systems involved. Neurosarcoidosis is an uncommon entity which is characterized by non-caseating granuloma infiltration of the central nervous system. Dysphagia in sarcoidosis is even more uncommon, and can involve one or more pathophysiological mechanisms: central nervous system involvement (cranial nerves associated with swallowing), lower motor neuron involvement (invasion of the enteric nervous plexus), direct muscle infiltration (invasion of the skeletal muscle portion of the esophagus and posterior pharynx), or mechanical obstruction (extrinsic compression by mediastinal lymph nodes). We report a case of a middle-aged woman presenting with severe dysphagia due to neurosarcoidosis which markedly improved after starting corticosteroids. The purpose of this case report is to highlight an atypical presentation of this disease.
Bartonella clarridgeiae infection in a patient with aortic root abscess and endocarditis
Authors: Julie M J Logan, Jessica L Hall, Vicki J Chalker, Brian O'Connell, Richard J Birtles
Journal: Access Microbiol (2019)
Keywords: bartonella, endocarditis, zoonosis
MeSH terms: Case Reports

Introduction:

Bartonella species are increasingly recognized as agents of culture-negative endocarditis. However, to date, almost all human cases have been associated with two members of the genus, Bartonella henselae and Bartonella quintana. B. henselae infections are zoonotic, with domestic cats serving as reservoir hosts for the pathogen. Bartonella clarridgeiae also exploits cats as reservoir hosts, but its zoonotic potential is far less established.
Case presentation:
A 34-year-old male presented with palpitations after a history of aortic incompetence. During surgery for an aortic valve replacement, two vegetations were found on the aortic valve. PCR analysis of the vegetation demonstrated the presence of Bartonella species and so the patient was treated post-operatively with ceftriaxone and doxycycline, making a good recovery. Further PCR-based analysis of the patient's aortic vegetation confirmed the presence of B. clarridgeiae .
Conclusion:
This report expands the number of Bartonella species associated with endocarditis and provides clear evidence that B. clarridgeiae should be considered a zoonotic pathogen.
Acute and Fatal Isoniazid-Induced Hepatotoxicity: A Case Report and Review of the Literature
Authors: Wissam K Kabbara, Aline T Sarkis, Paola G Saroufim
Journal: Case Rep Infect Dis (2016)

This paper describes a case of an acute and fatal isoniazid-induced hepatotoxicity and provides a review of the literature. A 65-year-old female diagnosed with latent Mycobacterium tuberculosis infection was receiving oral isoniazid 300 mg daily. She was admitted to the hospital for epigastric and right sided flank pain of one-week duration. Laboratory results and imaging confirmed hepatitis. After ruling out all other possible causes, she was diagnosed with isoniazid-induced acute hepatitis (probable association by the Naranjo scale). After discharge, the patient was readmitted and suffered from severe coagulopathy, metabolic acidosis, acute kidney injury, hepatic encephalopathy, and cardiorespiratory arrest necessitating two rounds of cardiopulmonary resuscitation. Despite maximal hemodynamic support, the patient did not survive. A review of the literature, from several European countries and the United States of America, revealed a low incidence of mortality due to isoniazid-induced hepatotoxicity when used as a single agent for latent Mycobacterium tuberculosis infection. As for the management, the first step consists of withdrawing isoniazid and rechallenge is usually discouraged. Few treatment modalities have been proposed; however there is no robust evidence to support any of them. Routine monitoring for hepatotoxicity in patients receiving isoniazid is warranted to prevent morbidity and mortality.
Leukoerythroblastosis as an Unusual Presentation of Parvovirus B19 Infection in a Sickle Cell Patient
Authors: Pratik A Patel, Elizabeth P Weinzierl, Daniel S Wechsler
Journal: Case Rep Pediatr (2020)
MeSH terms: Case Reports

Parvovirus B19 infection in pediatrics most commonly causes fifth disease, a mild viral illness. Hematologic manifestations include severe anemia, especially in patients with chronic hemolytic anemias or who are immunocompromised. Because of the shortened life span of erythrocytes in patients with sickle cell disease, parvovirus infection can cause transient aplastic crisis which can be life-threatening. However, leukocytosis and thrombocytosis are rarely seen. We report leukoerythroblastosis as an unusual presentation of acute parvovirus B19 infection in a previously splenectomized 12-year-old boy with sickle cell disease.
Complete septate uterus with obstructed hemivagina and ipsilateral renal agenesis (OHVIRA) in a young woman-a rare variant of Herlyn-Werner-Wunderlich syndrome
Authors: Mukesh Surya, Sita Thakur, Kamal Singh, Pawan Soni, Dinesh Sood, Preeti Takkar Kapila
Journal: BJR Case Rep (2016)
MeSH terms: Case Reports

Obstructed hemivagina and ipsilateral renal agenesis (OHVIRA) is an unusual and special type of Müllerian duct anomaly. Patients usually present in adolescence, soon after menarche, with pain and pelvic mass and rarely with infertility in adulthood. Majority of the cases of OHVIRA have been reported in association with uterus didelphys and the presentation of uterus didelphys with OHVIRA is known as Herlyn-Werner-Wunderlich syndrome. A complete septate uterus with OHVIRA is exceedingly unusual. Less than 30 cases of complete septate uterus with OHVIRA have been reported to date, to the best of our knowledge. We present a rare case of incidentally detected complete septate uterus with OHVIRA in a young woman who presented with acute pain in the right iliac fossa owing to acute appendicitis.
Acquired von Willebrand Syndrome in IgM Monoclonal Gammopathy as the Presentation of Lymphoplasmacytic Lymphoma
Authors: Zachary Wolfe, Bradley Lash
Journal: Case Rep Hematol (2017)
MeSH terms: Case Reports

Acquired von Willebrand syndrome (AVWS) is an increasingly recognized entity with numerous potential underlying etiologies. Most commonly implicated are lymphoproliferative, myeloproliferative, cardiovascular, and autoimmune disorders. Unlike inherited von Willebrand disease (vWD), AVWS tends to present at an older age and without a family history of vWD. Treatment is directed at the underlying etiology if one is uncovered, as well as treatment and prevention of bleeding. Here, we present a rare case of AVWS secondary to Waldenström macroglobulinemia which went unrecognized for several years but resolved promptly with treatment. The potential mechanisms of AVWS secondary to monoclonal gammopathies are discussed as well as strategies to treat and prevent bleeding in these patients.