OpenMed/multicare-articles huggingface dataset:
Case Report: A Child With Functional Chronic Duodenal Obstruction Caused by Megaduodenum
Authors: Zhibo Qu, Biao Zheng, Chuncheng Ju, Jiaxu Liu, Bingyang Liu, Haoran Zhang
Journal: Front Pediatr (2021)
Keywords: duodenal obstruction, functional, megaduodenum, pediatric, surgery
MeSH terms: Case Reports

Megaduodenum is a clinical syndrome which is characterized by the remarkable expansion of duodenum. Megaduodenum can be caused by mechanical or functional chronic duodenal obstruction. Functional chronic duodenal obstruction of megaduodenum in children is a clinical syndrome characterized by non-mechanical obstruction of the duodenum and marked expansion. It is an extremely rare congenital disease. Our paper report a 1-year-old girl with functional chronic duodenal obstruction caused by megaduodenum.
Ultrasound-guided pulse-dose radiofrequency: treatment of neuropathic pain after brachial plexus lesion and arm revascularization
Authors: Ernesta Magistroni, Davide Ciclamini, Bernardino Panero, Valter Verna
Journal: Case Rep Med (2014)

Neuropathic pain following brachial plexus injury is a severe sequela that is difficult to treat. Pulsed radiofrequency (PRF) has been proved to reduce neuropathic pain after nerve injury, even though the underlying mechanism remains unclear. This case report describes the use of ultrasound-guided PRF to reduce neuropathic pain in a double-level upper extremity nerve injury. A 25-year-old man who sustained a complete left brachial plexus injury with cervical root avulsion came to our attention. Since 2007 the patient has suffered from neuropathic pain (NP) involving the ulnar side of the forearm, the proximal third of the forearm, and the thumb. No pain relief was obtained by means of surgery, rehabilitation, and medications. Ultrasound-guided PRF was performed on the ulnar nerve at the elbow level. The median nerve received a PRF treatment at wrist level. After the treatment, the patient reported a consistent reduction of pain in his hand. We measured a 70% reduction of pain on the VAS scale. PRF treatment allowed our patient to return to work after a period of absence enforced by severe pain. This case showed that PRF is a useful tool when pharmacological therapy is inadequate for pain control in posttraumatic neuropathic pain.
A case of idiopathic gastroesophageal submucosal hematoma in a patient with no predisposition to bleeding
Authors: Takaaki Iwado, Hirokazu Honda, Tatsuhiro Gotoda
Journal: DEN Open (2023)
Keywords: esophageal hematoma, esophageal intramural hematoma, esophageal submucosal hematoma, gastroesophageal hematoma, gastrointestinal hematoma
MeSH terms: Case Reports

Gastroesophageal submucosal hematoma is a disease in which blood vessels in the gastroesophageal submucosa rupture and form a hematoma. In this report, we describe a case of gastroesophageal submucosal hematoma that developed due to vomiting in a patient with no history of bleeding and resolved with conservative treatment. A 69-year-old man presented with precordial pain and hematemesis after vomiting. A diagnosis of idiopathic gastroesophageal submucosal hematoma was made by computed tomography scan, magnetic resonance imaging, and esophagogastroduodenoscopy. Healing was achieved by conservative treatment with fasting, rehydration, and acid suppression. When a patient presents with sudden chest pain, hematemesis, and dysphagia, the possibility of this disease should be considered.
Response of an aggressive periosteal aneurysmal bone cyst (ABC) of the radius to denosumab therapy
Authors: Chantal Pauli, Bruno Fuchs, Christian Pfirrmann, Julia A Bridge, Silvia Hofer, Beata Bode
Journal: World J Surg Oncol (2014)
MeSH terms: Antibodies, Monoclonal, Humanized / therapeutic use, Bone Cysts, Aneurysmal / drug therapy, Bone Neoplasms / drug therapy, Periosteum / drug effects, Radius / drug effects, Case Reports, Adult, Bone Cysts, Aneurysmal / genetics, Bone Cysts, Aneurysmal / pathology, Bone Neoplasms / genetics, Bone Neoplasms / pathology, Denosumab, Female, Humans, In Situ Hybridization, Fluorescence, Periosteum / pathology, Prognosis, Proto-Oncogene Proteins / genetics, RANK Ligand / antagonists & inhibitors, Radius / pathology, Ubiquitin Thiolesterase / genetics, Young Adult, Antibodies, Monoclonal, Humanized, Proto-Oncogene Proteins, RANK Ligand, Denosumab, USP6 protein, human, Ubiquitin Thiolesterase

Aneurysmal bone cyst (ABC), once considered a reactive lesion, has been proven to be a neoplasia characterized by rearrangements of the USP6-gene. Aggressive local growth and recurrences are common and therapeutic options may be limited due to the vicinity of crucial structures. We describe a case of a locally aggressive, multinucleated giant cell-containing lesion of the forearm of a 21-year old woman, treated with denosumab for recurrent, surgically uncontrollable disease. Under the influence of this RANKL inhibitor, the tumor showed a marked reduction of the content of the osteoclastic giant cells and an extensive metaplastic osteoid production leading to the bony containment, mostly located intracortically in the proximal radius. The diagnosis of a periosteal ABC was confirmed by FISH demonstrating USP6 gene rearrangement on the initial biopsy. Function conserving surgery could be performed, enabling reconstruction of the affected bone. Inhibition of RANKL with denosumab may offer therapeutic option for patients not only with giant cell tumors but also with ABCs.
Symptoms of exhibitionism that regress with bupropion: A case report
Authors: Sefa Vayısoğlu
Journal: Front Psychiatry (2023)
Keywords: bupropion, dopaminergic activity, exhibitionistic disorder, serotonergic antidepressants, treatment
MeSH terms: Case Reports

Exhibitionistic Disorder, one of the paraphilic disorders, is a disease with an unknown etiology and causes significant distress and loss of function in the patient's life. Serotonergic antidepressants are generally preferred in the treatment of this Disorder. However, in this case, we report a patient who did not respond to serotonergic antidepressants but bupropion, an antidepressant with dopaminergic and noradrenergic activity. Therefore, bupropion should be considered a medical treatment alternative in case serotonergic antidepressants do not work efficiently in the treatment of Exhibitionism.
Acute Confusional Migraine: Unusual Great Masquerader-Case Report and Literature Review
Authors: Bashar Tanous, Raad Tahtouh, Sundus Sardar, Sara Mohamed, Aseel Sukik, Mhd-Baraa Habib, Jamal Sajid, Mouhand F H Mohamed
Journal: Case Rep Neurol Med (2020)
MeSH terms: Case Reports

Background. Acute confusional migraine (ACM) is a rare variant of migraine, mainly prevalent in children and adolescents. It is not currently indexed as a distinct variant of migraine likely since only a few cases were reported in the adult population. We report a case of delayed ACM diagnosis in a young man and present a concise-related literature review. Case Presentation. A thirty-eight-year-old man with a past medical history of migraine, not on any treatment, presented with headaches accompanied by confusion. Over a two-year period before the current presentation, he experienced two episodes of confusion, which required hospital admission for evaluation: once mislabeled as a psychiatric illness and diagnosed as a migrainous infarct in the second hospitalization. In the current presentation, he reported a similar history of headache accompanied by confusion. The examination was remarkable for disorientation; otherwise, no focal deficit was elicited. Laboratory testing, cerebrospinal fluid, and neurological imaging were all unremarkable. His symptoms improved spontaneously within less than twenty-four hours, similar to his previous presentations. After two-year history of episodic confusion and after excluding other plausible causes of confusion, guided by proposed diagnostic criteria, we diagnosed him as a case of ACM. The patient remains well at the follow-up of two months after discharge. Discussion and Conclusion. ACM is a rare variant of migraine and is often a challenge for clinicians to diagnose appropriately. Until recent years, the disease was thought to be limited to children and adolescents. However, recently few reports also expanded the incidence of this entity to the adult population. There is a significant gap in knowledge about proper identification and treatment of this condition, leading to delayed or overlooked ACM diagnosis. Moreover, the recent edition of the International Classification of Headache Disorders (ICHD-3) does not account for this entity, thereby further adding to physicians' lack of awareness regarding this migraine subtype. The authors emphasize that clinicians be aware of this entity and adequately utilize the existing proposed diagnostic criteria for ACM until standardized and validated tools are available. We also believe that this entity should be acknowledged in the subsequent migraine guidelines and classifications.
The sheared central venous catheter?
Authors: Harihar V Hegde, Vijay G Yaliwal, Shyamsundar K Joshi, P Raghavendra Rao
Journal: Case Rep Anesthesiol (2011)
MeSH terms: Case Reports

A fractured central venous catheter (CVC) with embolization of the distal fragment may lead to life-threatening complications. We had inserted a right subclavian CVC in a 68-year-old female which upon a follow-up chest X-ray appeared to have been sheared. A guidewire was inserted through the CVC until the J-tip was just beyond the tip of the CVC which were then withdrawn as a single assembly. We suspected that the tip of the guidewire might have been entrapped in the opening of the middle port, which upon withdrawal of the guidewire could have led to CVC folding upon itself and shearing.
An unusual occurrence of synovial sarcoma in forearm: a case report
Authors: Karthikeyan Selvaraj, Bharathiraja Kuppusami, Manimaran Ramachandran, Rajiv Kannan, Ravishankar Kalambur Sundaram
Journal: Pan Afr Med J (2021)
Keywords: soft tissue sarcomas, case report, extremities, synovial sarcoma, triceps muscle
MeSH terms: Sarcoma, Sarcoma, Synovial / diagnosis, Soft Tissue Neoplasms / diagnosis, Case Reports, Forearm, Humans, Magnetic Resonance Imaging

Soft tissue sarcomas are group of malignant tumours arising from extra skeletal mesenchymal tissue. Presenting a patient with swelling over the posterior aspect of left arm for 6 months, gradually increasing in size for four months and rapidly increasing in size for last 2 months and not associated with pain. Peripheral pulses felt. Ultrasound showed large solid cystic intramuscular lesion arising from triceps muscle and Trucut biopsy showed poorly differentiated malignancy. Magnetic resonance imaging (MRI) left arm impression was large lobulated solid cystic space occupying lesion in triceps muscle, possibility of neoplastic lesion. Here the patient underwent wide local excision and reconstruction procedure followed by Radiotherapy, chemotherapy and regular follow up.
Pulmonary Thromboembolism and Infarction Mimicking COVID-19 Symptoms; Report of three Cases
Authors: Rama Bozorgmehr, Mehdi Pishgahi, Zohreh Tajabadi, Mohammad Aryafar
Journal: Arch Acad Emerg Med (2020)
Keywords: covid-19, pulmonary embolism, pulmonary infarction, respiratory, signs and symptoms, venous thrombosis
MeSH terms: Case Reports

Since the novel coronavirus emerged in late December, 2019 in Wuhan, China, millions of people have been infected and thousands of patients have died. Fever and dyspnea are the most common symptoms of infection with SARS-CoV-2. However, these symptoms are neither specific nor diagnostic for COVID-19. Symptom overlap between COVID-19 and some other conditions may lead other diseases to be missed and underdiagnosed. Just like COVID-19, pulmonary thromboembolism (PTE) and pulmonary infarction may present with fever and respiratory symptoms. Since COVID-19 emerged and spread worldwide, many clinicians are focused on diagnosis and treatment of this novel viral infection. Hence, other diseases presenting with the same symptoms as COVID-19 may remain underdiagnosed. Here, we report three cases of PTE and pulmonary infarction presenting with fever and respiratory symptoms mimicking COVID-19.
Flare or foe? - Mycobacterium marinum infection mimicking rheumatoid arthritis tenosynovitis: case report and literature review
Authors: Nils Schubert, Tillmann Schill, Marlene Plüß, Peter Korsten
Journal: BMC Rheumatol (2020)
Keywords: atypical mycobacteria, immunosuppressive agents, mycobacterium marinum, rheumatoid arthritis
MeSH terms: Case Reports

Background:
Rheumatoid arthritis is the most common type of inflammatory arthritis affecting about 1% of the population. With the advent of disease-modifying anti-rheumatic drugs the disease can be well controlled in many cases. Patients, however, are prone to developing infectious complications. In rare cases, these can mimic a flare of the underlying itself.
Case presentation:
We report the case of a 45-year-old female patient with a history of seronegative rheumatoid arthritis (RA) who presented with swelling and tenderness of the third metacarpophalangeal joint of the right hand. A flare of her RA was suspected based on clinical and ultrasound findings which showed a tenosynovitis with intense power doppler activity. Her steroid dose was increased but the clinical response to glucocorticoid therapy was very limited. Subsequently, she developed skin manifestations of 'swimmer's granuloma' over the next 2 weeks after first presentation. Finally, a diagnosis of a Mycobacterium marinum infection was established with the help of tissue biopsy and culture, and the patient received appropriate antibiotic treatment with the desired effect.
Conclusions:
This case highlights the difficulty of distinction between infection and inflammation in patients with joint swelling and pain, especially in the age of disease-modifying drugs (DMARDs) and the concomitant risk of atypical infections. A review of the literature identified eight additional published cases, which suggests that Mycobacterium marinum infection is a rare but recognized complication of DMARD therapy. It can mimic a flare of the underlying arthritis potentially leading to diagnostic delays, and requires differential diagnostic methods to identify the pathogen and pave the way for appropriate treatment.
SMART Syndrome: Case Report and Review of the Literature
Authors: Christophe Dossin, Dario Di Perri, Nicolas Whenham, Anna Paola Bocchio, Idil Gunes Tatar
Journal: J Belg Soc Radiol (2023)
Keywords: migraine, radiation, smart, stroke-like

Stroke-like migraine attacks after radiation therapy (SMART) syndrome is a rare condition characterized by stroke-like deficits, seizures, and headache that can occur years after radiation therapy (RT) to the brain. RT is a cornerstone in the treatment of primary brain tumours and is indicated in more than 90% of patients. It is therefore essential to be aware of this entity to prevent misdiagnosis leading to inappropriate treatment. In this article, typical imaging findings of this condition are presented through a case report and review of the literature.
Small bowel volvulus with intussusception: an unusual revelation of neuroendocrine tumor
Authors: Imad Lachhab, Boubacar Zan Traoré, Omar Saoud, Yahia Zain Al Abidine Khedid, Fouad Zouaidia, Mahjoub Echarrab, Mohamed Rachid Chkoff
Journal: Pan Afr Med J (2015)
Keywords: intestines, intussusception, neuroendocrine tumor, small, volvulus
MeSH terms: Intestinal Obstruction / etiology, Intestinal Volvulus / etiology, Intussusception / etiology, Neuroendocrine Tumors / diagnosis, Case Reports, Adult, Female, Follow-Up Studies, Humans, Intestinal Obstruction / surgery, Intestinal Volvulus / surgery, Intestine, Small / pathology, Intussusception / surgery, Neuroendocrine Tumors / complications, Neuroendocrine Tumors / surgery, Tomography, X-Ray Computed

The primary malignant tumors of the small bowel are rare, representing 1 to 1.4% of all gastrointestinal tumors. We report a case of a 33 year-old women, admitted to our emergency department of visceral surgery for acute abdomen. The clinical examination revealed diffuse abdominal distension, defenseless, the hernia orifices were free and the rectal examination was normal. The biological test showed no hydro electrolytic disorders with normal hemoglobin and normal renal function. The abdominal CT-Scan showed signs of bowel obstruction due to a volvulus with intussusception without ischemia. The patient was operated urgently; the exploration has revealed a small bowel obstruction in the ileum with volvulus, an intussusceptum associated with a retractile mesenteritis, and the hepatic exploration found no metastases. The patient underwent a bowel resection taking away the intussusceptum with the infiltrated mesentery. The postoperative course was uneventful. The pathological result has proved a well-differentiated neuroendocrine tumor with five free nodes. Through this observation, we aim to highlight that an obstruction of small bowel with volvulus and intussusception could be exceptionally due to a neuroendocrine tumor, this complication has enabled a relatively early diagnosis in the absence of metastases and a 6-month follow-up without recurrence is a demonstration.
Squamous Cell Carcinoma Arising within Verruca Vulgaris on the Nipple
Authors: Araya Zaesim, Amanda C Jackson, Sang Wook Lee, Shaun A Price
Journal: Case Rep Dermatol Med (2018)
MeSH terms: Case Reports

Cutaneous squamous cell carcinoma (SCC) is a common form of skin cancer and often appears as a hard, scaly lump that occasionally ulcerates. It is usually associated with cumulative exposure to ultraviolet light, although prior scarring, chronic wounds, exposure to radiation, HPV infection, and immunosuppression are also associated risk factors. Primary SCC of the nipple is very rare and only a few cases have been reported. We present a case of a 49-year-old female with concerns of a right nipple lesion with erythema and pain. She was initially evaluated for Paget's disease with an underlying malignancy and cellulitis, but, after biopsy and investigation, she was found to have a well-differentiated SCC arising from a verruca vulgaris. Current literature does not provide distinct guidelines on management of SCC or its variants on the nipple, and the case was managed based off of SCC at other cutaneous sites as well as other cases of SCC on the nipple.
First-Episode of Synthetic Cannabinoid-Induced Psychosis in a Young Adult, Successfully Managed with Hospitalization and Risperidone
Authors: Aaron J Roberto, Aileen Lorenzo, Kevin J Li, Jonathan Young, Abhishek Mohan, Subhash Pinnaka, Kyle A B Lapidus
Journal: Case Rep Psychiatry (2016)

Synthetic cannabinoids- (SCs-) induced psychosis is a growing public health concern. It leads to significant impairment, including emotional distress, difficulty communicating, and other debilitating symptoms. In this case report, we discuss a patient with no previous history of psychotic symptoms, presenting with first-episode psychosis in the context of progressive, acutely worsening, disorganized, psychotic thoughts and behaviors following prolonged use of SCs. We also discuss relevant literature on SCs-induced psychosis, highlighting its prevalence, presentation, diagnosis, and recommended management. It is important to diagnose and treat SCs-induced psychosis as early and efficiently as possible, in order to alleviate symptoms while limiting functional impairment and emotional distress to the patient.
CDH1 Missense Variant c.1679C>G (p.T560R) Completely Disrupts Normal Splicing through Creation of a Novel 5' Splice Site
Authors: Zarina Yelskaya, Ruben Bacares, Erin Salo-Mullen, Joshua Somar, Deborah A Lehrich, Grace-Ann Fasaye, Daniel G Coit, Laura H Tang, Zsofia K Stadler, Liying Zhang
Journal: PLoS One (2016)
MeSH terms: Cadherins / genetics, RNA Splicing, Case Reports, Alleles, Antigens, CD, Base Sequence, DNA Mutational Analysis, Exons, Genetic Predisposition to Disease, Germ-Line Mutation, Humans, Male, Middle Aged, Pedigree, RNA Splice Sites, Sequence Deletion, Stomach Neoplasms / genetics, Stomach Neoplasms / pathology, Antigens, CD, CDH1 protein, human, Cadherins, RNA Splice Sites

Disease-causing germline mutations in CDH1 cause Hereditary Diffuse Gastric Cancer (HDGC). For patients who meet the HDGC screening criteria, the identification and classification of the sequence variants found in CDH1 are critical for risk management of patients. In this report, we describe a germline CDH1 c.1679C>G (p.T560R) variant identified in a 50 year old man who was diagnosed with gastric cancer with a strong family history of gastric cancer (one living brother was diagnosed with gastric cancer at 63 and another brother died of gastric cancer at 45). cDNA analysis, involving fragment analysis and cloning, indicated that the p.T560R mutation created a novel 5' splice donor site, which led to a novel transcript with a 32 nucleotide deletion in exon 11. This abnormal transcript putatively produces a truncated CDH1 protein (E-cadherin) of 575 amino acids instead of 882. We also demonstrated that the variant completely abolishes normal splicing as the mutant allele does not generate any normal transcript. Furthermore, the CDH1 c.1679C>G (p.T560R) variant segregated with gastric cancer in all three family members affected with gastric cancer in this family. These results support the conclusion that CDH1 c.1679C>G (p.T560R) variant is a pathogenic mutation and contributes to HDGC through disruption of normal splicing.
Oral Myiasis Caused by Cochliomyia hominivorax in a Disabled Person
Authors: José Pereira Novo-Neto, Fabiano de Sant'Ana Dos Santos, Ana Emília Farias Pontes, Fernando Salimon Ribeiro, Fábio Luiz Ferreira Scannavino, Alex Tadeu Martins
Journal: Case Rep Pathol (2015)

Myiasis is a parasitic disease caused by developing maggots of fly species, which can infect humans. Patients with special needs, especially those with severe neuropsychomotor limitations, may have oral manifestations of this disease. Here, we present a clinical case in which a disabled person was affected by oral myiasis caused by Cochliomyia hominivorax. Maggots were found in two ulcerated lesions, a 2 cm diameter lesion in the maxilla and a 6 cm diameter lesion in the mandible. Forty-five maggots were removed during inspection, whereas 75 maggots were surgically removed under general anesthesia with nasotracheal intubation. Dipyrone, ivermectin, and clindamycin were prescribed, and the patient remained hospitalized for 3 days. Seven days after surgical intervention, no maggots were observed. Our study emphasizes that dentists must recognize the symptoms and behaviors of parasitic diseases that affect the oral cavity.
The Placement of Four Short Implants and Full-Arch Early Loading in the Edentulous Patient Suffering from Severe Mandibular Alveolar Ridge Atrophy
Authors: Yuri Sedov, Oleg Mordanov, Sergei Grigoriev, Anatoly Avanesov, Kamil Khabiev
Journal: Case Rep Dent (2019)
MeSH terms: Case Reports

One of the treatments of patients with severe bone atrophy is short implants. It is important to position short implants taking into account the prosthetic loading and right position according to vital anatomical structures. In the presented case report, a seventy-one-year-old female patient underwent the rehabilitation with four short dental implants placed in the anterior mandibula with fully guided surgery to avoid mandibular incisive canal. It solves all the problems in the planning stage when you determine the osteotomy protocol in advance and the prognosis of future restoration according to patient requirements. This clinical case demonstrates the efficiency of patient rehabilitation with the use of short implants in difficult clinical situations.