OpenMed/multicare-articles huggingface dataset:
Acquired Lymphangiectasia of the Scrotum Successfully Treated with Radiofrequency Ablation: A Case Report with Dermoscopic Review
Authors: Dhan Keshar Khadka, Raksha Pathak, Sudha Agrawal, Sairil Pokharel
Journal: Case Rep Dermatol Med (2023)
MeSH terms: Case Reports

Lymphangiectasia is dilatation of normal superficial lymphatic vessels due to damage or obstruction of deep lymphatic vessels leading to increased lymphatic pressure and engorgement of dermal lymphatics due to varying causes. Lymphangiectasia clinically presents as thick-walled, translucent vesicles and papules with chronic lymphedema rarely involving the scrotum. Here we report a patient with acquired lymphangiectasia of the scrotum secondary to surgery for hydrocele successfully treated with radiofrequency ablation. We highlight the use of dermoscopy as a non-invasive diagnostic tool in lymphangiectasia.
Osteonecrosis of the jaw in a Crohn's disease patient following a course of Bisphosphonate and Adalimumab therapy: a case report
Authors: Raimund H M Preidl, Tobias Ebker, Martin Raithel, Falk Wehrhan, Friedrich W Neukam, Philipp Stockmann
Journal: BMC Gastroenterol (2014)
MeSH terms: Anti-Inflammatory Agents / adverse effects, Antibodies, Monoclonal, Humanized / adverse effects, Bisphosphonate-Associated Osteonecrosis of the Jaw / etiology, Bone Density Conservation Agents / adverse effects, Crohn Disease / drug therapy, Diphosphonates / adverse effects, Case Reports, Research Support, Non-U.S. Gov't, Adalimumab, Adult, Female, Humans, Osteonecrosis / drug therapy, Anti-Inflammatory Agents, Antibodies, Monoclonal, Humanized, Bone Density Conservation Agents, Diphosphonates, Adalimumab

Background:
Bisphosphonates have a widespread indication for osteoporosis and are also applied in cancer patients with skeletal-related conditions. Bisphosphonate-associated osteonecrosis of the jaw (BRONJ) is a feared side effect which is hard to treat and often affects patient's quality of life in an extensive manner. Adalimumab (Humira®), a fully human recombinant antibody specific for tumor necrosis factor- α, is approved for treatment in patients with Inflammatory Bowel Disease like ulcerative colitis or Crohn's disease.
Case presentation:
In March 2013, a 36-year-old female presented with right-sided perimandibular swelling, recurrent facial pain and exposed necrotic bone after previous extraction of tooth 47. She had the medical history of Crohn's disease for more than one decade with chronic active enterocolitis, fistula disease as well as previous oral manifestation and was currently treated with Adalimumab since September 2008. Due to steroid-induced osteoporosis, diagnosed in 2004, she received oral Bisphosphonates (Risedronate) from 2004 until 2007 followed by two infusions of Zoledronic acid in 2008 and 2009.
Conclusion:
This patient with a medical history of Crohn's disease and gastrointestinal remission under Adalimumab therapy presented with osteonecrosis of the jaw after suspended oral and intravenous Bisphosphonate therapy implicating that the biologic therapy with an anti-TNF-α antibody might promote the manifestation of osteonecrosis and compromise oral healing capacity.
Genomic Heterogeneity of Methicillin Resistant Staphylococcus aureus Associated with Variation in Severity of Illness among Children with Acute Hematogenous Osteomyelitis
Authors: Claudia Gaviria-Agudelo, Chukwuemika Aroh, Naureen Tareen, Edward K Wakeland, MinSoo Kim, Lawson A Copley
Journal: PLoS One (2015)
MeSH terms: Methicillin-Resistant Staphylococcus aureus / genetics, Osteomyelitis / pathology, Severity of Illness Index, Staphylococcal Infections / pathology, Case Reports, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Acute Disease, Adolescent, Child, Child, Preschool, Demography, Genetic Heterogeneity, High-Throughput Nucleotide Sequencing, Humans, Infant, Methicillin-Resistant Staphylococcus aureus / classification, Methicillin-Resistant Staphylococcus aureus / isolation & purification, Multilocus Sequence Typing, Osteomyelitis / metabolism, Osteomyelitis / microbiology, Phylogeny, Polymorphism, Single Nucleotide, Prospective Studies, Sequence Analysis, DNA, Staphylococcal Infections / metabolism, Staphylococcal Infections / microbiology, Virulence / genetics

Introduction:
The association between severity of illness of children with osteomyelitis caused by Methicillin-resistant Staphylococcus aureus (MRSA) and genomic variation of the causative organism has not been previously investigated. The purpose of this study is to assess genomic heterogeneity among MRSA isolates from children with osteomyelitis who have diverse severity of illness.
Materials and methods:
Children with osteomyelitis were prospectively studied between 2010 and 2011. Severity of illness of the affected children was determined from clinical and laboratory parameters. MRSA isolates were analyzed with next generation sequencing (NGS) and optical mapping. Sequence data was used for multi-locus sequence typing (MLST), phylogenetic analysis by maximum likelihood (PAML), and identification of virulence genes and single nucleotide polymorphisms (SNP) relative to reference strains.
Results:
The twelve children studied demonstrated severity of illness scores ranging from 0 (mild) to 9 (severe). All isolates were USA300, ST 8, SCC mec IVa MRSA by MLST. The isolates differed from reference strains by 2 insertions (40 Kb each) and 2 deletions (10 and 25 Kb) but had no rearrangements or copy number variations. There was a higher occurrence of virulence genes among study isolates when compared to the reference strains (p = 0.0124). There were an average of 11 nonsynonymous SNPs per strain. PAML demonstrated heterogeneity of study isolates from each other and from the reference strains.
Discussion:
Genomic heterogeneity exists among MRSA isolates causing osteomyelitis among children in a single community. These variations may play a role in the pathogenesis of variation in clinical severity among these children.
Case report: Early acute myocarditis after radiation therapy for breast cancer: A case presentation and review of literature
Authors: Mohammadbagher Sharifkazemi, Mahsa Elahi, Masoud Sayad
Journal: Front Cardiovasc Med (2023)
Keywords: acute myocarditis, breast cancer, cardiomyopathies, myocarditis, radiation-induced
MeSH terms: Case Reports

Breast cancer is the most commonly diagnosed cancer in women worldwide, and with the increased survival of patients by novel treatments, the frequency of complications of cancer treatments rises. Radiotherapy, especially on the chest wall, can damage different cardiac structures. Radiotherapy-induced cardiomyopathy mainly occurs over 10 years after breast cancer treatment; however, there is a gap in the literature on acute myocarditis following radiotherapy. Here, we present a 54-year-old woman who developed acute myocarditis shortly after 25 sessions of radiotherapy with 50 Gy of radiation, successfully diagnosed with the use of speckle tracking echocardiography (STE) and cardiac magnetic resonance (CMR), and responded to the medical treatment with relative clinical improvement until the final follow-up. This case suggests the necessity of detailed examination of patients after radiotherapy, not only for chronic occurrence of cardiomyopathy but also for acute myocarditis. Although STE and CMR resulted in accurate diagnosis, in this case, further studies are required to determine the diagnostic accuracy of these two imaging methods compared with other imaging modalities in such patients and investigate the best diagnostic tool and therapeutic approach for these patients.
Unusual presentation of a rare tumor of the dorsal surface of the foot
Authors: O Hocar, H Yacoubi, N Akhdari, S Amal, F Ait Essi, M Latifi, H Rais, B Belaabidia
Journal: ISRN Dermatol (2011)
MeSH terms: Case Reports

Calcifying aponeurotic fibroma (CAF) was originally described by Keasbey in 1953 as juvenile aponeurotic fibroma, most commonly occurring in the palms of the hands and soles of the feet in children and adolescents. It usually presents as a firm, painless mass without preceding trauma. We report a case of this rare condition with an unusual presentation in a 60-year-old woman affecting the dorsal surface of the foot. It is a relatively benign condition with a good prognosis following complete surgical excision. It may have a slightly increased incidence in males. The accurate diagnosis is based only on histology but it is essential to differentiate it from other sinister lesions such as fibrosarcoma that may lead to amputation.
Meningitis With Staphylococcus aureus Bacteremia in an Older Patient With Nonspecific Symptoms: A Case Report
Authors: Airi Minatogawa, Junya Ohara, Yuta Horinishi, Chiaki Sano, Ryuichi Ohta
Journal: Cureus (2023)
Keywords: erector pili muscle abscess, general malaise, general medicine, meningitis, rural hospital, staphylococcus aureus bacteremia
MeSH terms: Case Reports

Staphylococcus aureus bacteremia has been associated with various symptoms that can spread to diverse organs, including the meninges, which can be challenging to diagnose given the nonspecific symptoms. Early examination, including assessment of the cerebrospinal fluid, is necessary when a patient is diagnosed with S. aureus bacteremia accompanied by unconsciousness. A 73-year-old male presented to our hospital complaining of general malaise without fever. The patient developed impaired consciousness immediately after hospitalization. Following the investigations, the patient was diagnosed with S. aureus bacteremia and meningitis. If a patient presents with symptoms of unknown cause and acute progressive disease, meningitis and bacteremia should always be considered. Blood cultures should be performed promptly, affording an early diagnosis, bacteremia treatment, and the establishment of meningitis.
Intestinal Myiasis Caused by Sarcophaga spp. in Cusco, Peru: A Case Report and Review of the Literature
Authors: Priscilla Ly, Adiel Aizenberg, Taylor Martin, Martha Lopez, Miguel Arturo Saldaña, Grant Leslie Hughes, Miguel Mauricio Cabada
Journal: Case Rep Infect Dis (2018)
MeSH terms: Case Reports

Myiasis is the infestation by dipterous fly larvae in humans and animals. The larvae can infect living or necrotic tissue involving the skin, nasopharynx, genitourinary, and gastrointestinal tracts. The accidental ingestion of eggs causes infection of the intestinal tract. We report a case of intestinal myiasis caused by Sarcophaga spp. larvae in a two-year-old child from Limatambo province in the Cusco region of Peru. Live larvae were identified incidentally in this child's stool sample during the study screening for Strongyloides stercoralis. The child did not have any constitutional or abdominal symptoms. The morphological examination of the specimen under magnification revealed Sarcophaga spp. larvae. We performed a literature review of publications reporting intestinal myiasis caused by Sarcophaga spp. and discussed key aspects of this infestation.
Congenital spigelian hernia and cryptorchidism: another case of new syndrome
Authors: Dhiraj Parihar, Yogender Singh Kadian, Preeti Raikwar, Kamal Nain Rattan
Journal: APSP J Case Rep (2013)
Keywords: agenesis, cryptorchidism, inguinal canal, spigelian hernia
MeSH terms: Case Reports

Spigelian hernia (SH) is rarely seen in pediatric age group and is usually associated with cryptorchidism on the same side; termed as a syndromic association of the defect in the Spigelian fascia and absence of gubernaculum and inguinal canal. The absence of the inguinal canal has surgical implication as to placement of the undescended testis into the scrotum. A 3-month-old baby presented with spigelian hernia and ipsilateral impalpable testis. The spigelian hernia was repaired and undescended testis which was present in abdominal wall layers was brought to scrotum with cord structures anterior to external oblique muscle.
Gastric Schwannoma: A Case Report and Review of the Literature for Gastric Submucosal Masses Distinction
Authors: Behnam Sanei, Amirhosein Kefayat, Melika Samadi, Parvin Goli, Mohammad Hossein Sanei, Mahsa Khodadustan
Journal: Case Rep Med (2018)
MeSH terms: Case Reports

Schwannomas origin from Schwann cells sheath and generally are benign, slow-growing, and asymptomatic neoplasms which frequently appear in the head and neck. Although gastrointestinal schwannoma is really rare, the most affected organ in GI system is the stomach. Gastric schwannoma forms 0.2% of all gastric tumors. This neoplasm is always detected as a submucosal mass, the same as other gastrointestinal stromal tumors. Although these tumors have almost the same presentations, they are completely different at therapeutic options and prognoses. Hence, it is important to distinguish them apart and make an accurate diagnosis to optimize treatment outcomes. Herein, we report a case of 28-year-old woman with frequent vomiting and abdominal pain caused by 5 × 6 cm schwannoma in the antrum of the stomach. This is a rare case of gastric outlet obstruction due to a massive schwannoma. In addition, all other probable submucosal masses will be discussed at different aspects.
Massive Gastric Hemorrhage due to Dieulafoy's Lesion in a Preterm Neonate: A Case Report and Literature Review of the Lesion in Neonates
Authors: Christos Salakos, Panayiota Kafritsa, Yvelise de Verney, Ariadni Sageorgi, Nick Zavras
Journal: Case Rep Pediatr (2015)

Dieulafoy's lesion is an extremely rare cause of upper gastrointestinal bleeding in the neonatal age group. Till now, only 6 cases of Dieulafoy's lesion in neonatal period have been reported in the international literature. Herein, we report an extremely rare case of Dieulafoy's lesion in a preterm neonate.
Malignant Spinal Cord Compression Syndrome as an Initial Presentation of Testicular Cancer
Authors: Carlos Eduardo Salazar-Mejía, Edio Llerena-Hernández, David Hernández-Barajas, Oscar Vidal-Gutiérrez, Adriana González-Gutiérrez, Rolando Jacob Martínez-Granados, Blanca Otilia Wimer-Castillo
Journal: Case Rep Oncol Med (2018)
MeSH terms: Case Reports

Malignant spinal cord compression syndrome (MSCCS) occurs in 2.5 to 5% of all oncological patients. In 20% of the cases, it is the initial manifestation. This syndrome is a rare event among germ cell tumors (GCT), occurring in only 1.7% of the patients. We present the case of a 24-year-old man who arrived at the emergency department with dysesthesia and paraparesis as well as urinary incontinence. Imaging studies showed an infiltrative lesion in the left testicle, pulmonary and hepatic metastatic disease, and a large retroperitoneal ganglionar conglomerate that infiltrated the spinal cord through the intervertebral foramina of the vertebra level T11 with displacement of the L1 vertebral body. A postoperative biopsy showed a pure embryonal carcinoma. In the initial approach of a young man who presents spinal cord compression, the presence of MSCCS associated with GCT should be considered as a possible cause. A high level of suspicion is required to achieve a timely diagnosis, to grant the patient the best possible outcome.
Effective monotherapy with amrubicin for a refractory extrapulmonary small-cell carcinoma of the liver
Authors: Taichi Isobe, Shunichi Yanai, Hitoshi Kusaba, Shinichiro Yada, Yosuke Kuroda, Sadafumi Tamiya, Takayuki Matsumoto, Eishi Baba, Mine Harada
Journal: Case Rep Med (2009)
MeSH terms: Case Reports

Small-cell carcinoma of the liver is a rare neoplasm, and no standard treatment for it has yet been established. A 72-year-old man with an extensive disease stage of small-cell carcinoma of the liver was treated with systemic chemotherapy consisting of cisplatin and etoposide (PE) followed by irinotecan. Although the masses were markedly decreased once after the sixth course of PE, amrubicin monotherapy as third-line chemotherapy was started because the hepatic masses had increased again. The administration of amrubicin was repeated in 8 courses with regression of the disease, resulting in a 26-month survival since the first-line chemotherapy was started. This is the first case report of a refractory EPSCC successfully treated with amrubicin.
Dealing with pre-existing chronic neutropenia in cancer patients-considerations and consequences in the clinical praxis
Authors: Anna-Birgitte Thinggaard, Gabor Liposits, Niels Fristrup
Journal: Ecancermedicalscience (2020)
Keywords: autoimmune neutropenia, chemotherapy, chronic idiopathic neutropenia, chronic neutropenia, monoclonal antibodies, targeted therapy
MeSH terms: Case Reports

Chronic neutropenia is a rare but important challenge with substantial clinical implications for patients receiving antineoplastic treatment. Treatment-induced neutropenia is a well-known adverse event during chemotherapy and some targeted treatments. Guidelines for administering chemotherapy are rather strict to protect the patient from severe and life-threatening complications. Consequently, patients with chronic neutropenia may receive suboptimal antineoplastic treatment. Autoimmune neutropenia or chronic idiopathic neutropenia (CIN) may affect the antineoplastic treatment by causing delayed drug delivery, dose reductions and early discontinuation of treatment. CIN is characterised by the onset in late childhood or adulthood, affects mostly women, is clinically benign and has rare spontaneous remission. Here, we elucidate the challenges related to chronic neutropenia when administering chemotherapy through two clinical cases. Guidelines may need to be revised in order to optimise the treatment of patients with asymptomatic chronic neutropenia, thus personalising the medical decisions for each patient.
Psychotherapy in India
Authors: L S S Manickam
Journal: Indian J Psychiatry (2010)
Keywords: india, psychotherapy, psychotherapy research

The articles that appeared in Indian Journal of Psychiatry were related to different areas of psychotherapy. Case reports dealt with a wide variety of cases. The review papers focused on the suitability of psychotherapy in the Indian context, different approaches in psychotherapy, psychotherapy training and supervision. Psychotherapy has been viewed very close to faith orientation. There were attempts to identify the indigenous concepts that are applicable to psychotherapy. Empirical studies are low in number. Concerted effort is needed to generate interest in psychotherapy, conduct more research on evidence-based therapies as well as on psychotherapeutic process variables.
Case Report: Primary lymphoepithelioma-like intrahepatic cholangiocarcinoma
Authors: Fei Liu, Qing Xu, Parbatraj Regmi, Fu-Yu Li, Yi-Xin Lin
Journal: Front Oncol (2023)
Keywords: ebv – epstein-barr virus, lel-icc, lesion, liver, surgical resection
MeSH terms: Case Reports

Background:
Lymphoepithelioma-like intrahepatic cholangiocarcinoma (LEL-ICC) is a rare variant of intrahepatic cholangiocarcinoma. Epstein-Barr virus (EBV) infection was considered to play a pivotal role in the tumorigenesis of LEL-ICC. It is difficult to diagnosis of LEL-ICC due to the lack of specific features regarding the laboratory test results and imaging findings. At present, the diagnosis of LEL-ICC mainly depends on the histopathologic and immunohistochemical examinations. In addition, the prognosis of LEL-ICC was better than classical cholangiocarcinomas. To our knowledge, only few cases of LEL-ICC have been reported in the literature.
Case presentation:
We presented a case of a 32-year-old Chinese female with LEL-ICC. She had a 6-month history of upper abdominal pain. The magnetic resonance imaging (MRI) showed a 1.1× 1.3 cm lesion in the left lobe of liver, appearing low signal intensity on T1-weighted images and high signal intensity on T2-weighted images. The patient underwent laparoscopic left lateral sectionectomy. The postoperative histopathologic and immunohistochemical examinations results allowed for the definitive diagnosis of LEL-ICC. The patient was free from tumor recurrence after a 28 months follow-up.
Conclusion:
In this study, we reported a rare case of LEL-ICC associated with both HBV and EBV infection. EBV infection might play a pivotal role in the carcinogenesis of LEL-ICC, and surgical resection is still the most effective treatment at present. Further research on the etiology and treatment strategies of LEL-ICC is required.
Umbilical Nodule with Cyclical Bleeding: A Case Report and Literature Review of Atypical Endometriosis
Authors: Marlene Teixeira Andrade, Cláudia V Marques de Freitas, Sara Filipa Camacho Câmara, José Joaquim Nunes Vieira
Journal: Case Rep Obstet Gynecol (2016)

Endometriosis is defined as the presence of endometrial glands and stroma outside the uterus. It affects 3 to 10 percent of women of reproductive age. Umbilical endometriosis is rare, with an estimated incidence of 0.5-1.0% among all cases of endometriosis, and is usually secondary to prior laparoscopic surgery involving the umbilicus. In this report, we described a case of umbilical endometriosis treated with surgical resection and highlight the great importance of medical history compared to complementary diagnostic tests that can be sometimes inconclusive.
Case report: Bullous pemphigoid in HIV-1-positive patients: interplay or coincidence? A case series and review of the literature
Authors: Yannick Foerster, Lukas Sollfrank, Laura Rechtien, Thomas Harrer, Carola Berking, Michael Sticherling
Journal: Front Immunol (2023)
Keywords: covid-19, hiv-1, aids, bullous pemphigoid, dupilumab, immune reconstitution inflammatory syndrome, iris
MeSH terms: Autoimmune Diseases / complications, HIV-1, Pemphigoid, Bullous / diagnosis, Pemphigoid, Bullous / drug therapy, Pemphigoid, Bullous / etiology, Review, Case Reports, Research Support, Non-U.S. Gov't, Aged, Blister, Humans, Interleukin-13, Interleukin-4, Interleukin-4, Interleukin-13

Bullous pemphigoid (BP) is an autoimmune inflammatory skin disease, mostly affecting the elderly population. Therefore, patients often have multiple comorbidities, but there is inconsistent data regarding the relationship between HIV-1 infection and BP, which has been rarely reported in combination. Herein, we describe three patients who presented with BP and concomitant HIV-1 infection that was well controlled with modern combined antiretroviral therapy. All patients received topical and oral corticosteroids. Depending on the individual severity, further add-on therapeutics, such as azathioprine, dapsone, doxycycline and the interleukin 4/13 antibody dupilumab, were added to the therapy regimen. All patients recovered from pruritic skin lesions and blistering. The cases are further discussed in the context of the current study landscape. In conclusion, HIV-1 infection shifts the cytokine profile from T-helper type 1 (TH1) towards T-helper type 2 (TH2), resulting in the excessive secretion of distinct cytokines, such as interleukin 4 (IL-4) and interleukin 10 (IL-10). With IL-4 being a main driver in the pathogenesis of BP, HIV-1-positive patients may benefit greatly from targeting IL-4 with monoclonal antibodies.