OpenMed/multicare-articles huggingface dataset:
Recurrent Aneurysmal Bone Cyst of the Distal Fibula Treated with Denosumab and Curettage
Authors: Philip B Fontenot, Jose Jesurajan, Marilyn Bui, Damon Reed, Odion Binitie
Journal: Case Rep Oncol Med (2018)
MeSH terms: Case Reports

We report the case of a 13-year-old girl with multiple recurrences of an aneurysmal bone cyst of the distal fibula successfully treated with denosumab and curettage. Aneurysmal bone cysts are locally aggressive lesions with high rates of recurrence. The novel use of denosumab with curettage in a long bone showed a favorable outcome with no adverse events or signs of recurrence three years after treatment.
Temporary Frontal Paralysis Secondary to Blunt Trauma Frontal Sinus Fracture
Authors: Mark Bastianelli, Stefan Hamilton, Matthew Hearn, Safeena Kherani, Kristian I Macdonald
Journal: Case Rep Otolaryngol (2017)
MeSH terms: Case Reports

Frontal sinus fractures (FSF) are relatively uncommon and can be challenging for trauma surgeons to manage. Patients with FSF typically present with facial swelling, pain, and nasofrontal ecchymosis. Here we present a rare case of a patient with FSF and anterior table fracture where the main presenting symptom was bilateral frontal paralysis. We outline our management strategy and review the current literature in regard to management of FSF.
Lumbo-costo-vertebral syndrome with congenital lumbar hernia
Authors: Lucky Gupta, Tariq Ahmed Mala, Rahul Gupta, Shahid Amin Malla
Journal: APSP J Case Rep (2014)
Keywords: absent ribs, congenital lumbar hernia, hemivertebra, meshplasty
MeSH terms: Case Reports

Lumbo-costo-vertebral syndrome (LCVS) is a set of rare abnormalities involving vertebral bodies, ribs, and abdominal wall. We present a case of LCVS in a 2-year-old girl who had a progressive swelling over left lumbar area noted for the last 12 months. Clinical examination revealed a reducible swelling with positive cough impulse. Ultrasonography showed a defect containing bowel loops in the left lumbar region. Chest x-ray showed scoliosis and hemivertebrae with absent lower ribs on left side. Meshplasty was done.
Case Report: Various Clinical Manifestations Caused by Varicella-Zoster Virus in a Family
Authors: Qinghong Meng, Bingsong Wang, Xianlai Zhang, Zhen Li, Wenjie Wang, Kaihu Yao
Journal: Front Pediatr (2022)
Keywords: atypical, breakthrough varicella, herpes zoster, varicella, varicella-zoster virus
MeSH terms: Case Reports

A family cluster of varicella-zoster virus (VZV) infections was reported. Four family members (two children and their parents) continuously develop varicella after the grandmother's herpes zoster. The unvaccinated 16-month-old infant and his mother developed primary varicella with atypical clinical presentation; however, his 28-year-old father presented with a typical generalized vesicular rash. His vaccinated 4-year-old sister was clinically mild, which could be defined as a breakthrough varicella case. They infected the same virus strain but presented various clinical forms.
FDG-PET findings of Ameloblastoma: a case report
Authors: Satoshi Seno, Kazuhiro Kitajima, Go Inokuchi, Ken-Ichi Nibu, Tomoo Itoh, Yasuo Ejima, Ryohei Sasaki, Koji Sugimoto, Kazuro Sugimura
Journal: Springerplus (2015)
Keywords: 18f-fluorodeoxyglucose (fdg), ameloblastoma, ct, mri, pet

Introduction:
Ameloblastoma is a benign odontogenic neoplasm of the jaw, rarely presenting as a malignant tumor. Although it is very important to discriminate ameloblastoma from ameloblastic carcinoma in order to decide the appropriate operative procedure, this is difficult using conventional CT and MRI.
Case descriptions:
We report a case of maxillar ameloblastoma in a 78-year-old man where FDG-PET/CT was useful for making this discrimination. CT demonstrated a 31 × 43 × 46-mm mass in the left posterior maxillary sinus with destruction of its posterior and lateral wall and alveolar bone. MRI demonstrated a hypo- to isointense heterogeneous pattern on T1WI, heterogeneous hyperintensity with a prominent high-signal spot on T2WI, high signal intensity on DWI reflecting restricted diffusion, and strong heterogeneous enhancement. Because FDG-PET/CT showed mild FDG uptake (SUVmax 2.40) by the mass, ameloblastoma, rather than ameloblastic carcinoma, was considered to be the correct diagnosis.
Discussion and evaluation:
It appears that ameloblastic carcinoma shows intense FDG uptake, whereas ameloblastoma shows mild or moderate FDG uptake, and only rarely intense FDG uptake. Our experience suggests that FDG-PET/CT may be effective for discriminating ameloblastoma from ameloblastic carcinoma. Especially, in cases showing mild FDG uptake, benign ameloblastoma would seem the most likely diagnosis.
Conclusions:
FDG-PET/CT may be useful as an adjunctive modality for diagnosis, treatment planning and surveillance of ameloblastoma and ameloblastic carcinoma.
Beyond new vaccine introduction: the uptake of pneumococcal conjugate vaccine in the African Region
Authors: Folake Olayinka, Leah Ewald, Robert Steinglass
Journal: Pan Afr Med J (2017)
Keywords: africa, immunization, child mortality, pneumonia, vaccination
MeSH terms: Immunization / statistics & numerical data, Pneumococcal Vaccines / administration & dosage, Vaccination Coverage / statistics & numerical data, Vaccines, Conjugate / administration & dosage, Africa, Child, Developing Countries, Diffusion of Innovation, Humans, Immunization / trends, Infant, Pneumococcal Vaccines / supply & distribution, Time Factors, Pneumococcal Vaccines, Vaccines, Conjugate

The number of vaccines available to low-income countries has increased dramatically over the last decade. Overall infant immunization coverage in the WHO African region has stagnated in the past few years while countries' ability to maintain high immunization coverage rates following introduction of new vaccines has been uneven. This case study examines post-introduction coverage among African countries that introduced PCV between 2008 and 2013 and the factors affecting Pneumococcal Conjugate Vaccine (PCV) introduction. Nearly one-third of countries did not achieve 80% infant PCV3 coverage by two years post-introduction and 58% of countries experienced a decline in coverage between post introduction years two and four. Major factors affecting coverage rates included introduction without adequate preparation, insufficient supply chain capacity and management, poor communication between organizations and with the public, and data collection systems that were insufficient to meet information needs. Deliberately addressing these issues as well as longstanding weaknesses during new vaccine introduction can strengthen the immunization and broader health system. Further study is required to identify and address factors that affect maintenance of high coverage following introduction of new vaccines in the African region. Immunization with PCV is one of the most important interventions protecting against pneumonia, the second leading cause of death for children under five globally.
Co-existence of breast and ovarian cancers in BRCA germ-line mutation carriers
Authors: A Dilawari, J Cangiarella, J Smith, A Huang, A Downey, F Muggia
Journal: Ecancermedicalscience (2008)
MeSH terms: Case Reports

The co-existence of breast and ovarian cancers in the same individual should raise suspicion of a hereditary process. Patients with either BRCA1 or BRCA2 germ-line mutations have an average risk of 39% and 11% respectively of developing ovarian cancer by the age of 70; they have a risk of 35-85% of developing breast cancer in their lifetime. We report here unusual pathologic features in a BRCA2 germ-line mutation carrier recently diagnosed with synchronous breast and ovarian cancers, and summarize the findings in six other women who were diagnosed with ovarian cancer either simultaneously with the diagnosis of breast cancer or at varying times after the diagnosis. While in most instances this may be a coincidental occurrence in highly susceptible individuals, the patient we highlight raises the provocative hypothesis that at times breast cancer metastasizes to the ovaries of mutation carriers and stimulates the development of an ovarian cancer as well as other cancers. In addition, these ovarian cancers may have different mechanisms of metastases predisposing them to travel to unusual sites.
Intervention Mapping to Adapt Evidence-Based Interventions for Use in Practice: Increasing Mammography among African American Women
Authors: Linda Highfield, Marieke A Hartman, Patricia Dolan Mullen, Serena A Rodriguez, Maria E Fernandez, L Kay Bartholomew
Journal: Biomed Res Int (2015)
MeSH terms: Black or African American, Evidence-Based Practice, Health Planning, Mammography, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Female, Humans, Texas

This paper describes and demonstrates the use of the systematic planning process, Intervention Mapping, to adapt an evidence-based public health intervention (EBI). We used a simplified version of Intervention Mapping (IM Adapt) to increase an intervention's fit with a new setting and population. IM Adapt guides researchers and practitioners in selecting an EBI, making decisions about whether and what to adapt, and executing the adaptation while guarding the EBI's essential elements (those responsible for effectiveness). We present a case study of a project in which we used IM Adapt to find, adapt, implement, and evaluate an EBI to improve mammography adherence for African American women in a new practice setting in Houston, Texas. IM Adapt includes the following (1) assess needs and organizational capacity; (2) find EBIs; (3) plan adaptations based on fit assessments; (4) make adaptations; (5) plan for implementation; and (6) plan for evaluation of the adapted EBI. The case study shows an example of how public health researchers and practitioners can use the tool to make it easier to find and use EBIs, thus encouraging greater uptake. IM Adapt adds to existing dissemination and adaptation models by providing detailed guidance on how to decide on effective adaptation, while maintaining the essential elements of the EBI.
Late Giant Aortic Root Aneurysm Following Aortic Valve Replacement
Authors: Rabia Azam, Metesh Acharya, Sonam Vadera, William Adair, Giovanni Mariscalco
Journal: Methodist Debakey Cardiovasc J (2022)
Keywords: aortic root aneurysm, aortic root expansion, aortic valve replacement
MeSH terms: Aortic Aneurysm / diagnostic imaging, Aortic Aneurysm / etiology, Aortic Aneurysm / surgery, Aortic Aneurysm, Thoracic / diagnostic imaging, Aortic Aneurysm, Thoracic / etiology, Aortic Aneurysm, Thoracic / surgery, Aortic Valve Insufficiency / surgery, Heart Valve Prosthesis, Sinus of Valsalva / diagnostic imaging, Sinus of Valsalva / surgery, Case Reports, Aged, Aged, 80 and over, Aortic Valve / diagnostic imaging, Aortic Valve / surgery, Female, Humans

A 74-year-old female with previous permanent pacemaker insertion for complete heart block and no history of connective tissue disease presented to our regional cardiothoracic center with progressive exertional shortness of breath. Nine years later, when the patient was 83 years old, a computed tomography scan of the thoracic aorta revealed an isolated aneurysm of the aortic root measuring 7.6 × 5.1 cm at the sinus of Valsalva.
Respiratory Disease following Illicit Injection of Silicone: A Case Report
Authors: Alex Charles Essenmacher, Seyed Amin Astani
Journal: Case Rep Med (2013)

Unregulated, pseudomedical procedures risk serious sequelae even when otherwise safe compounds are used. Silicone is commonly used legally in cosmetic procedures owing to its durability, resistance to heat and aging, and low immunogenicity. However, inappropriate or illegal silicone injection can pose severe local and systemic complications including serious pulmonary compromise. We describe the case of a 30-year-old female who presented with hemoptysis and progressive shortness of breath following illicit silicone injections to the gluteal fat and was found to have new, diffuse, bilateral, ground-glass opacities on contrast-enhanced pulmonary computed tomography. Transbronchial biopsy elucidated that this was a lipoid pneumonia-type injury secondary to silicone infiltration.
Sacral Ewing sarcoma with rib, lung, and multifocal skull metastases: A rare case report and review of treatments
Authors: Chen Ye, Wei Wei, Xuebin Tang, Feng Li, Baoquan Xin, Qianqian Chen, Haifeng Wei, Shaohui He, Jianru Xiao
Journal: Front Oncol (2022)
Keywords: decision optimization, en bloc resection, ewing sarcoma, multidisciplinary treatments, multifocal metastases
MeSH terms: Case Reports

Ewing sarcoma (ES) rarely derives from the sacrum or mobile spine. The discovery of primary ES with multimetastatic involvements is exceedingly less frequent in clinical practice. A 23-year-old man with initial primary sacral ES developed metastases of rib, lung, and multifocal skull after receiving surgical intervention and series of adjuvant therapies. We provide this very rare case consisting of its clinical features, imaging findings, treatments, and outcomes. Therapeutic modalities of ES are also reviewed in previous published articles. The prognosis of metastatic ES remains dismal; effective therapeutic modalities for ES require multidisciplinary collaboration, with more high-quality clinical trials to promote the optimal protocols.
Masked Polycythemia Vera and Iron Deficiency in a Fertile-Age Woman
Authors: Luís R Almeida, Diogo Faustino, Rita Gameiro, Vera Salvado, Luis Dias
Journal: Cureus (2023)
Keywords: chronic blood loss, iron deficiency, jak2 mutation, masked polycythemia vera, primary polycythemia
MeSH terms: Case Reports

Polycythemia vera (PV) is a myeloproliferative disorder that leads to increased red blood cell (RBC) mass. The V617F activating mutation for Janus kinase 2 (JAK2) is a classic finding in PV, but it is not exclusive to this condition. The radionuclide assay is an accurate method for accessing RBC, but hemoglobin (Hb) and hematocrit (Htc) values are frequently the first abnormal markers reported in a routine blood count and the basis for further investigation. Diagnostic criteria for PV were recently updated to include lower thresholds for Hb and Htc, increasing diagnostic sensitivity. However, it has been reported that a subset of patients does not meet these thresholds, besides having an active masked disease. We are presenting a case of a fertile-age woman with menometrorrhagia, whose blood loss and consequent iron depletion worked as a limiting factor for Hb and Htc increase, delaying the proper diagnosis. Splenomegaly, iron deficiency markers, and low erythropoietin supported PV investigation. The correction of iron depletion led to the unveiling of covert erythrocytosis. Concomitant hemoglobinopathies and secondary causes for erythrocytosis were excluded. The diagnosis was confirmed with polymerase chain reaction (PCR) for V617F-JAK2 mutation and bone marrow biopsy. As this case highlights, despite not meeting diagnostic criteria at presentation, masked PV exhibited clinical, laboratory, and imaging features of active symptomatic disease. For that, a higher level of suspicion must be held for fertile-age women who present with normal Hb and Htc levels and significant iron depletion, in the presence of low serum erythropoietin or splenomegaly.
Retroperitoneal schwannoma: a rare case
Authors: Murat Kalaycı, Umit Akyüz, Alp Demirağ, Bengi Gürses, Ferda Ozkan, Ozcan Gökçe
Journal: Case Rep Gastrointest Med (2011)
MeSH terms: Case Reports

Introduction. Schwannomas are quiet rare in the retroperitoneal region. Here, we describe an incidentally detected retroperitoneal schwannoma in the abdominal computerized tomography (CT) of a patient with acute appendicitis. Case Presentation. A 38-year-old woman was admitted to the emergency service with the complaints of progressive abdominal pain and nausea for the last 24 hours. Abdominal examination was compatible with acute abdomen. Acute appendicitis was diagnosed by CT. During CT evaluation, a round shaped soft-tissue mass at the retroperitoneal area inferior to the right kidney was detected, The mass was resected and histology revealed schwannoma. Conclusion. Rare tumoral lesions with benign course such as schwannoma can be detected incidentally.
Use of Awake Flexible Fiberoptic Bronchoscopic Nasal Intubation in Secure Airway Management for Reconstructive Surgery in a Pediatric Patient with Burn Contracture of the Neck
Authors: Tolga Totoz, Kerem Erkalp, Sirin Taskin, Ummahan Dalkilinc, Aysin Selcan
Journal: Case Rep Anesthesiol (2018)
MeSH terms: Case Reports

Although the use of awake flexible fiberoptic bronchoscopic (FFB) intubation is a well-recognized airway management technique in patients with difficult airway, its use in smaller children with burn contractures or in an uncooperative older child may be challenging. Herein, we report successful management of difficult airway in a 7-year-old boy with burn contracture of the neck, by application of FFB nasal intubation in a stepwise approach, first during an initial preoperative trial phase to increase patient cooperation and then during anesthesia induction for the reconstructive surgery planned for burn scars and contractures. Our findings emphasize the importance of a preplanned algorithm for airway control in secure airway management and feasibility of awake FFB intubation in a pediatric patient with burn contracture of the neck during anesthesia induction for reconstructive surgery. Application of FFB intubation based on a stepwise approach including a trial phase prior to operation day seemed to increase the chance of a successful intubation in our patient in terms of technical expertise and increased patient cooperation and tolerance by enabling familiarity with the procedure.
Skull repair after major crush injury
Authors: H Sudhoff, H J Hoff, M Lehmann
Journal: Case Rep Otolaryngol (2011)
MeSH terms: Case Reports

Reconstructive surgery after trauma of the head and neck is a wide field in ENT surgery. The repair of bony defects often requires implantation of engineered prostheses. We present the case of a 48-year-old male patient who had suffered a major crush injury to his head resulting in a complex bony defect. A computer-assisted designed (CAD/CAM) Titanium implant was used for reconstruction. Direct prefabrication of the individually designed implant led to an excellent coverage of the bony defect and easy adaptation to the defect margins. Results. Treatment plan and surgery as well as implant design and manufacturing were performed in a multidisciplinary team. Skin expander implantation prior to reconstructive surgery ensured a tension-free closure. This team approach led to a satisfactory outcome for this patient. This case illustrates the necessity of a multidisciplinary approach for the optimum management of complex head and neck injuries.
Lumbosacral plexopathy: A rare long term complication of concomitant chemo-radiation for cervical cancer
Authors: Imane Bourhafour, Meriem Benoulaid, Hanane El Kacemi, Sanae El Majjaoui, Tayeb Kebdani, Noureddine Benjaafar
Journal: Gynecol Oncol Res Pract (2015)
Keywords: lumbosacral plexus, radiation plexopathy, cervical carcinoma
MeSH terms: Case Reports

Radiation induced Lumbosacral plexophaty (RILP) is a rare but severe complication that has a considerable impact on quality of life. Its occurrence is rare but increasing with improved long-term cancer survival. This entity commonly results in different degrees of sensory and motor deficits. The pathophysiological mechanisms are not yet fully understood. Diagnosis of radiation myelopathy in women with gynecologic malignancies may increase with the use of concomitant chemo-radiation. This report describes the effect of this combination therapy in a 64-year-old woman with cervical carcinoma.
Do all type 2 aortic dissection require emergency surgery?
Authors: Taner İyigün, Mugisha Kyaruzi, Mehmet Kaya
Journal: J Surg Case Rep (2018)
MeSH terms: Case Reports

We represent a case of asymptomatic isolated chronic ascending aortic dissection that lasted for 15 years in which a patient was only followed up with medical therapy that saved him from early surgical intervention.
Targeted therapy with propranolol and metronomic chemotherapy combination: sustained complete response of a relapsing metastatic angiosarcoma
Authors: Shripad Banavali, Eddy Pasquier, Nicolas Andre
Journal: Ecancermedicalscience (2015)
Keywords: angiosarcoma, beta-blockers, celecoxib, cyclophosphamide, drug repositioning, etoposide, metronomic chemotherapy, palliative treatment, propranolol
MeSH terms: Case Reports

We report here a case of a 69-year-old woman with a relapsing metastatic angiosarcoma treated with a combination of metronomic chemotherapy and propranolol. The beta blockers were added since the tumour was positive for betaadrenergic receptor. A complete response was quickly obtained and lasted for 20 months. With this case, the combination of metronomic chemotherapy and propranolol in angiosarcoma warrants additional studies and illustrates the potential of metronomics to generate innovative yet inexpensive targeted therapies for both high-income and low-/middle-income countries.
Case Report: Vancomycin-Associated Tubulointerstitial Nephritis in Clinical Practice-Case Report and Review of Literature
Authors: Lakshmi Kannan, Rishi Raj
Journal: Front Med (Lausanne) (2022)
Keywords: mrsa, acute interstitial nephritis, kidney biopsy, nephrotoxicity, vancomycin
MeSH terms: Case Reports

Nephrotoxicity is one of the major limiting factors for vancomycin use. The most common histological patterns of kidney injury are acute tubulointerstitial nephritis and acute tubular necrosis. Patients who develop acute tubulointerstitial nephritis are prone to develop acute kidney injury with vancomycin rechallenge and, in most cases, present alone or as a part of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS). The purpose of the review study is to identify biopsy-proven vancomycin-associated-tubulointerstitial nephritis in literature, determine possible underlying pathophysiology and identify the consequences of vancomycin rechallenge in such patients.
Symptomatic Hypoalbuminemia as an Indication for Treatment of Waldenström Macroglobulinemia: A Case Report and Review of the Literature
Authors: Jeremy T Larsen, Frederick D Leonard
Journal: Case Rep Hematol (2019)
MeSH terms: Case Reports

Hypoalbuminemia has been reported as common in patients with symptomatic Waldenström macroglobulinemia (WM), but it is not typically mentioned as a manifestation of the disease in review articles or articles discussing indications for treatment. We present the case of a patient with WM for whom symptomatic hypoalbuminemia was the primary reason for initiating treatment. Except in rare cases of WM with renal or gastrointestinal involvement, hypoalbuminemia is thought to be due to the effects of elevated levels of inflammation-associated cytokines, and it has been associated with greater likelihood of progression of asymptomatic to symptomatic disease, greater disease severity, and poorer prognosis. Hypoalbuminemia in WM may become symptomatic, and it may be a reason to initiate treatment if symptoms affect quality of life.