OpenMed/multicare-articles huggingface dataset:
Dedifferentiated retroperitoneal large liposarcoma and laparoscopic treatment: Is it possible and safe? The first literature case report
Authors: Antonino Agrusa, Giuseppe Di Buono, Salvatore Buscemi, Brenda Randisi, Leonardo Gulotta, Vincenzo Sorce, Giuseppe Badalamenti, Domenico Albano, Massimo Galia, Giorgio Romano, Gaspare Gulotta
Journal: Int J Surg Case Rep (2019)
Keywords: 3d laparoscopic surgery, dedifferentiated liposarcoma, retroperitoneal liposarcoma

Introduction:
Soft tissue sarcomas are rare neoplasms often characterized by local invasiveness and distant metastasis with poor prognosis for affected patients. Among the most frequent sarcomas we find well-differentiated and dedifferentiated liposarcomas characterized by a better survival compared to the other histological types. When it is possible the only curative treatment for these neoplasms is surgical resection.
Case report:
We report a case of a 62-year-old caucasian woman with CT abdominal scan that demonstrated a voluminous solid oval mass in the left perirenal space with dislocation of the kidney and in continuity with the anterior renal fascia. After a percutaneous CT-guided biopsy of the mass the histopathological diagnosis was a dedifferentiated retroperitoneal liposarcoma. We performed a laparoscopic surgical resection of the retroperitoneal mass in block with kidney and left adrenal gland.
Discussion:
When possible, surgical resection with adequate margins represents the only curative therapeutic option for this pathology. Only a few papers are available in literature which take into consideration the possibility of laparoscopic approach for retroperitoneal masses with better vision of surgical field, reduction of post-operative pain and better cosmesis.
Conclusion:
A retroperitoneal mass represents a serious diagnostic challenge. The choice of the best surgical procedure can benefit to the patient prognosis. To our opinion laparoscopy can be a safe and successful treatment and it can represent a valid alternative to open surgery. However, we have no randomized controlled trials that compare laparoscopic versus open resection for retroperitoneal liposarcomas.
Synchronous squamous cell carcinoma and diffuse large B-cell lymphoma of the head and neck: the odd couple
Authors: Ann C Raldow, Johann G Brown, Nicole Chau, Matthew S Davids, Danielle N Margalit, Roy B Tishler, Andrea Ng, Jonathan D Schoenfeld
Journal: BJR Case Rep (2016)
MeSH terms: Case Reports

We report the case of an 81-year-old male with synchronous recurrent cutaneous squamous cell carcinoma (SCC) metastatic to the parotid and diffuse large B-cell lymphoma of the head and neck. These malignancies necessitated integrated multidisciplinary treatment within a short time period. Superficial parotidectomy was followed by chemotherapy for lymphoma. The subsequent radiation treatment plan combined both sequential boost to treat the SCC surgical bed to a higher dose compared with the lymphoma, and dose-painting intensity-modulated radiation therapy (IMRT) to differentially dose the areas at risk. The treatment was tolerated well. The restaging scans demonstrated no evidence of either lymphoma or SCC. This case highlights the importance of combined modality treatment for two concurrent aggressive malignancies in the head and neck region. Radiation treatment planning incorporated both sequential boost and dose-painting IMRT to integrate comprehensive treatment for both malignancies.
Interactive Family Dynamics and Non-suicidal Self-Injury in Psychiatric Adolescent Patients: A Single Case Study
Authors: Michela Gatta, Marina Miscioscia, Marta Sisti, Ilaria Comis, Pier Antonio Battistella
Journal: Front Psychol (2017)
Keywords: lausanne trilogue play, adolescence, family functioning, family interactions, non-suicidal self-injury

Non-Suicidal Self-Injury (NSSI) is a common, multifaceted phenomenon among adolescents. Recent researchers have shown that a number of psychological and psychiatric correlates are implicated in the onset/repetition of NSSI, but those previous studies did not directly observe the family interaction patterns of this clinical population. In this paper, the quality of family interactions was observed using the Lausanne Trilogue Play procedure to deepen the specific interactive dimensions associated with NSSI in adolescents. The results of a single case study showed a lack of positive emotional exchanges, a parenting style expressing hostility, a high level of control and difficulties in triangulation. Through this method, the authors show that a better understanding of the role of family interactions is crucial and could improve the assessment and treatment of Non-Suicidal Self-Injurious behaviors. Research and clinical implications are discussed.
Systemic Lupus Erythematosus Complicated with Hypertrophic Cardiomyopathy: A Case Report and Literature Review
Authors: Huihui Ma, Xin Cao, Jing Zhang, Yongmei Zhou, Rong Luo, Tao He, Jianhong Tao, Xiaoping Li
Journal: Case Rep Cardiol (2021)
MeSH terms: Case Reports

A 32-year-old female with systemic lupus erythematosus (SLE) for more than 7 years, and long-term treatment with cyclophosphamide, cyclosporine, methotrexate, and tacrolimus, later found to be combined with hypertrophic cardiomyopathy (HCM) for one year. The patient denied a family history of cardiomyopathy and sudden cardiac death (SCD). Echocardiography suggested that uneven thickening of the left ventricle (LV), mainly in the lower middle segment. Cardiac magnetic resonance (CMR) showed that the walls of the left ventricular (LV) were significantly thickened, as about 21 mm, mainly in the middle and lower segments. Genetic tests showed no known or suspected pathogenic variations were found and no significant enhancement in CMR, so secondary HCM was diagnosed clinically. After symptomatic treatment, the patient was discharged, and long-term follow-up was conducted. The diagnosis of HCM, which combined with SLE or second to usage of tacrolimus, was based on symptoms, echocardiography, and CMR; no endomyocardial biopsies were performed.
The Diagnostic Challenge of Eosinophilic Granulomatosis With Polyangiitis Presenting as Acute Eosinophilic Myocarditis: Case Report and Literature Review
Authors: Hiroyuki Yamamoto, Katsuya Hashimoto, Yoshihiko Ikeda, Jun Isogai, Toru Hashimoto
Journal: Front Cardiovasc Med (2022)
Keywords: cmr, egpa, emb, acute em, corticosteroid treatment, hypereosinophilia
MeSH terms: Case Reports

Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic vasculitis involving small-to-medium-sized vessels characterized by asthma, vasculitis, and peripheral eosinophilia. EGPA-associated eosinophilic myocarditis (EM) occurs rarely, yet can be fatal if left untreated. Moreover, the accurate diagnosis of EGPA-associated EM without vasculitis is exceptionally difficult because of the overlapping features with EM of other causes. We report a case of probable EGPA with subclinical neurological involvement that presented with acute EM. The constellation of peripheral eosinophilia, left ventricular dysfunction, and normal epicardial coronary arteries raised suspicion of acute EM, which was confirmed by cardiac magnetic resonance (CMR) investigation and endomyocardial biopsy (EMB). Prompt systemic administration of corticosteroids completely restored and normalized myocardial structure and function. Although the patient's history suggested the presumed hypersensitivity myocarditis, EMB revealed EM without vasculitis, not hypersensitivity, leading to a tentative diagnosis of idiopathic hypereosinophilic syndrome. Interestingly, the characteristic findings of vasculitis on CMR imaging strongly suggested EGPA-associated EM. Although the patient had no clinical neurological manifestations, a nerve conduction study confirmed mononeuritis multiplex, leading to the final diagnosis of probable EGPA. Therefore, this case highlights the diagnostic challenge associated with EGPA and the diagnostic synergy of CMR and EMB for an exploratory diagnosis of EGPA-associated EM.
Persistent Zika Virus Detection in Semen in a Traveler Returning to the United Kingdom from Brazil, 2016
Authors: Katherine M Gaskell, Catherine Houlihan, Eleni Nastouli, Anna M Checkley
Journal: Emerg Infect Dis (2017)
Keywords: rna detection, zika virus, asymptomatic, infection, infectious diseases, isolation, persistence, semen, sexual transmission risk, vector-borne infections, viruses
MeSH terms: Semen / virology, Zika Virus / isolation & purification, Zika Virus Infection / virology, Case Reports, Antibodies, Viral / blood, Brazil, Humans, Immunoglobulin G / blood, Immunoglobulin M / blood, Male, Middle Aged, RNA, Viral / urine, Time Factors, Travel, United Kingdom, Zika Virus / genetics, Zika Virus / immunology, Zika Virus / pathogenicity, Zika Virus Infection / blood, Zika Virus Infection / transmission, Zika Virus Infection / urine, Antibodies, Viral, Immunoglobulin G, Immunoglobulin M, RNA, Viral

Zika virus is normally transmitted by mosquitos, but cases of sexual transmission have been reported. We describe a patient with symptomatic Zika virus infection in whom the virus was detected in semen for 92 days. Our findings support recommendations for 6 months of barrier contraceptive use after symptomatic Zika virus infection.
A case of atypical vivax malaria with a global review of reports on myriads of morpho-variations in parasitized red blood cells
Authors: Debasish Biswal, Bijay Ranjan Mirdha
Journal: Access Microbiol (2023)
Keywords: pcr assay, hypovolaemia, microgametocytes, morphological variations, vivax malaria
MeSH terms: Case Reports

Plasmodium vivax, one of the major species associated with human malaria, continues to be a major public health problem in many parts of the world. Numerous studies related to vivax malaria have described quantitative haematological findings (level of haemoglobin, thrombocytopaenia, haematocrit values), but diverse morphological changes of parasite forms within infected red blood cells (iRBCs) have been mentioned only in few studies. Here we report a case of a 13-year-old boy who presented with fever, significant low platelet counts and hypovolaemia that created a diagnostic dilemma. Detection of microgametocytes by microscopic examinations, further confirmed by multiplex nested PCR assays and response to anti-malarials, helped to make the diagnosis. We present an atypical case of vivax malaria with a review of morpho-variations of iRBCs and have summarized the characteristics that aid in creating increased awareness among laboratory health professionals and public health workers.
VATS bullectomy and apical pleurectomy for spontaneous pneumothorax in a young patient with Swyer-James-Mc Leod syndrome: case report presentation and literature review focusing on surgically treated cases
Authors: Nikolaos Panagopoulos, Gerasimos Papavasileiou, Efstratios Koletsis, Myrto Kastanaki, Nikolaos Anastasiou
Journal: J Cardiothorac Surg (2014)
MeSH terms: Lung, Hyperlucent / complications, Pneumonectomy / methods, Pneumothorax / surgery, Thoracic Surgery, Video-Assisted / methods, Case Reports, Research Support, Non-U.S. Gov't, Review, Adolescent, Angiography, Follow-Up Studies, Humans, Lung, Hyperlucent / diagnostic imaging, Male, Pneumothorax / diagnostic imaging, Pneumothorax / etiology, Radiography, Thoracic, Tomography, X-Ray Computed

Background:
Swyer-James-McLeod Syndrome (SJMS) is an uncommon, emphysematous disease characterized by radiologic hyperlucency of pulmonary parenchyma due to loss of the pulmonary vascular structure and to alveolar overdistension.
Case report:
We herein describe a 15-year-old Caucasian patient with well-established SJMS since childhood who presented with spontaneous pneumothorax. Video-assisted thoracoscopic bullectomy with apical pleurectomy was performed. Since SJMS is considered an on-going inflammatory process, the patient one year after surgery exhibits excellent quality of life with no pneumothorax recurrence.
Surgical treatment of a ventricular aneurysm in a patient with essential thrombocythemia complicated by acute myocardial infarction: A case report
Authors: Dong-Wen Wang, Yong Zhang, Jian-Min Yao, Zhi-Bin Xiao
Journal: Exp Ther Med (2014)
Keywords: acute myocardial infarction, essential thrombocythemia, surgical treatment, ventricular aneurysm

Essential thrombocythemia (ET) is a chronic clonal myeloproliferative disorder, which is often complicated by arterial or venous thrombosis and idiopathic bleeding diathesis. The present study reports a female patient with ET complicated by acute myocardial infarction, leading to ventricular aneurysm following interventional therapy for 3 years and a subsequent in-stent restenosis. Following careful examination, a ventricular aneurysm resection and coronary artery bypass graft were carried out. During this case, the monitoring and controlling of the platelet count, pre- and post-operatively, was extremely important for successful surgery.
The terminal period findings of late-diagnosed fibrodysplasia ossificans progressiva
Authors: Emrah Doğan, Hüseyin Aydoğmuş, Cenk Elibol, Sinem Aydoğmuş
Journal: Ger Med Sci (2023)
MeSH terms: Arthrogryposis, Bunion, Myositis Ossificans / diagnostic imaging, Case Reports, Adult, Clavicle, Clonal Hematopoiesis, Female, Humans, Young Adult

Fibrodysplasia ossificans progressiva (FOP) is an autosomal dominant rare disease characterized by foot deformities and concomitant heterotopic ossifications. Theoretically, in the absence of early diagnosis and medication, the patient's outcome will be poor. The patients are usually diagnosed at an early age. Hence, encountering a non-treated and terminal-period patient is rare. Our case was unique because it showed the clinical picture and atypical radiological distribution of a 20-year-old, terminally ill untreated female patient. She had hallux valgus, heterotopic ossifications and multiple osteochondromas that were detected in the right clavicula, the posterior arch of the 9th rib, the bilateral tibia and fibula. Atypically, heterotopic ossifications were not present in the soft tissues of the neck. Hand deformity, cardiac anomaly, or mental retardation was not observed. It was a sporadic case. The presentation with neurological symptoms was also atypical.
Case Report: Recurrent Autoimmune Hypoglycemia Induced by Non-Hypoglycemic Medications
Authors: Qiuping Zhu, Hanxin Zhao, Wei Qiu, Fang Wu, Chungen Qian, Yonghong Yang, Ye Kang, Fenping Zheng, Jiaqiang Zhou
Journal: Front Immunol (2022)
Keywords: case report, clopidogrel, hypoglycemia, insulin autoantibodies, insulin autoimmune syndrome
MeSH terms: Autoimmune Diseases / diagnosis, Autoimmune Diseases / drug therapy, Hypoglycemia / chemically induced, Hypoglycemia / diagnosis, Hypoglycemia / drug therapy, Case Reports, Review, Clopidogrel / therapeutic use, Humans, Insulin, Insulin Antibodies / therapeutic use, Insulin, Insulin Antibodies, Clopidogrel

We present a case of recurrent autoimmune hypoglycemia induced by non-hypoglycemic agents. We review reported cases of autoimmune hypoglycemia related to non-hypoglycemic agents, and discuss the effects of different detection methods for insulin autoantibodies on the results obtained. We aim to provide information for clinicians and a warning for medication usage. Considering the increasing number of clopidogrel-induced AIH cases and the hypoglycemia-induced increase in the risk of cardiovascular events, we recommend that cardiovascular disease patients being treated with clopidogrel be informed of this rare side effect and that clinicians be vigilant for the possibility of autoimmune hypoglycemia in this patient population.
Dorsal Arachnoid Web: A Rare Cause of Myelopathy
Authors: Arvy Buttiens, Bart Feyen, Sven Dekeyzer
Journal: J Belg Soc Radiol (2021)
Keywords: ct myelography, mri, spine, arachnoid, myelopathy, web
MeSH terms: Case Reports

Teaching point: The scalpel sign is pathognomonic for a dorsal arachnoid web, a rare clinical-radiologic entity that can cause myelopathy.
Fatal Plasmodium falciparum, Clostridium perfringens, and Candida spp. Coinfections in a Traveler to Haiti
Authors: Gillian L Genrich, Julu Bhatnagar, Christopher D Paddock, Sherif R Zaki
Journal: J Trop Med (2009)
MeSH terms: Case Reports

Malaria is one of the most common causes of febrile illness in travelers. Coinfections with bacterial, viral, and fungal pathogens may not be suspected unless a patient fails to respond to malaria treatment. Using novel immunohistochemical and molecular techniques, Plasmodium falciparum, Clostridium perfringens, and Candida spp. coinfections were confirmed in a German traveler to Haiti. Plasmodium falciparum-induced ischemia may have increased this patient's susceptibility to C. perfringens and disseminated candidiasis leading to his death. When a patient presents with P. falciparum and shock and is unresponsive to malaria treatment, secondary infections should be suspected to initiate appropriate treatment.
One-Stage Implant-Retaining Revision for Simultaneous Bilateral Infected Total Knee Arthroplasty: A Report of a Rare Case
Authors: Nils Wirries, Lars-René Tuecking, Michael Skutek
Journal: Case Rep Orthop (2021)
MeSH terms: Case Reports

There is little information on the management of simultaneous infected total knee arthroplasties in the same patient. Although general principles of management for periprosthetic joint infection apply, there might be certain aspects worth to be considered. We present a case of a 78-year-old patient, who was referred in preseptic conditions 10 years following bilateral TKA. The onset of symptoms was less than one week, proposing an acute hematogenous infection. Analysis of joint fluid revealed that both of his TKAs were infected with Streptococcus sanguinis. Diagnostic algorithms, surgical principles, and the course of the patients following bilateral revision are being described. The reasons for an implant-retaining procedure with irrigation and debridement including the exchange of the polyethylene liners are being discussed as well as possible principles of management of bilateral periprosthetic joint infections.
Acute myeloid leukemia in a father and son with a germline mutation of ASXL1
Authors: Karen Seiter, Kyaw Htun, Paul Baskind, Zach Liu
Journal: Biomark Res (2018)
Keywords: asxl1, familial acute myeloid leukemia, familial myelodysplastic syndrome, nextgen sequencing
MeSH terms: Case Reports

Background:
Myelodysplastic syndromes and acute myeloid leukemia usually occur sporadically in older adults. More recently cases of familial acute myeloid leukemia and/or myelodysplastic syndrome have been reported.
Case presentation:
Currently we report a father and son who both developed myelodysplastic syndrome that progressed to acute myeloid leukemia. Both patients were found to have the identical mutation of ASXL1 on nextgen sequencing of both hematologic and nonhematologic tissues.
Conclusions:
These cases support the diagnosis of a germline mutation of ASXL1.
Successful treatment of a Candida auris intra-articular infection
Authors: Scott C Roberts, Teresa R Zembower, Maureen K Bolon, Anish R Kadakia, Jasen H Gilley, Jason H Ko, Jessica Clark, Sharon Ward-Fore, Babafemi O Taiwo
Journal: Emerg Microbes Infect (2019)
Keywords: amphotericin cement spacer, intra-articular infection
MeSH terms: Antifungal Agents / administration & dosage, Candida / physiology, Candidiasis / drug therapy, Cartilage, Articular / microbiology, Case Reports, Aged, Amphotericin B / administration & dosage, Candida / drug effects, Candida / genetics, Candida / isolation & purification, Candidiasis / diagnosis, Candidiasis / microbiology, Caspofungin / administration & dosage, Drug Therapy, Combination, Female, Fluconazole / administration & dosage, Humans, Antifungal Agents, Amphotericin B, Fluconazole, Caspofungin

A 78-year-old woman with a long-term ankle spacer with antibacterials developed an intra-articular Candida auris infection. Treatment with systemic antifungal therapy plus an amphotericin B moulded cement spacer was successful.
Skeletal involvement in children with Langerhans cell histiocytosis: healing, complications, and functional outcome
Authors: Ahmed H K Abdelaal, Mohamed Sedky, Seham Gohar, Iman Zaki, Asmaa Salama, Omayma Hassanain, Ahmed M El Ghoneimy
Journal: SICOT J (2020)
Keywords: langerhans cell histiocytosis, skeletal, spontaneous remodeling
MeSH terms: Case Reports

Introduction:
Skeletal involvement in children with Langerhans cell histiocytosis (LCH) is a common feature of the disease. Several options for the treatment of these skeletal lesions have been reported. We describe our experience in the treatment of skeletal involvement of LCH in this retrospective case series study, entailing anatomic distribution, pattern of healing, skeletal deformities, and functional outcome of skeletal LCH.
Methods:
A retrospective analysis was conducted for patients diagnosed with LCH and having skeletal lesions in the period between 2007 and 2015. Out of a total of 229 cases, 191 (83.4%) had skeletal involvement. Bone healing was divided into partial and complete based on the size of lesion and cortical changes in plain radiograph. Skeletal deformities were serially measured. Time to pain control, resumption of weight bearing, and the final functional status of the patient were reviewed.
Results:
The mean age at presentation was 4.4 years (3 m-14.8 y) and the mean follow-up period was 53.3 months (0.2-120.7). After screening of skeletal and extra-skeletal lesions, 59 patients (31%) had M-S (Multisystem) LCH and 132 (69%) had S-S (Single system) LCH. Unifocal bone lesions were found in 81 (42.5%) patients, and multifocal bone lesions in 110 patients (57.5%). Single or multiple bone lesions were found in the craniofacial bones in 152 patients (79.5%), femur in 19 patients, (10%), ribs in 18 patients (9.4%), spine in 15 patients (8.1%), pelvis in 14 patients (7.3%), scapula in 8 patients (4.1%), humerus in 6 (3.1%), clavicle in 6 patients (3.1%), tibia in 3 patients (1.5%), radius in 3 patients (1.5%), and the ulna in 2 patients (1%) patients. No lesions were found in the fibula, hand, or foot. Out of all skeletal lesions, 179 (93.7%) patients were treated either medically or conservatively and 12 patients (6.2%) were treated surgically. The mean time to complete healing was 5.2 months (2-12). Skeletal complications included: pathologic fractures (9 vertebra plana, 5 long bone, 1 iliac bone), deformities (9 thoracolumbar kyphosis, 2 cervical spine subluxations, 2 coxa vara deformity of the proximal femur and one flattening of iliac bone).
Conclusion:
Non-operative treatment can lead to adequate bone healing in few months period. Partial or complete remodeling of bone deformities can be observed without surgical correction. However, surgical intervention might be indicated when cervical spine affection may lead to instability and subsequent neurological affection. Functional impairment is rarely caused by skeletal lesions in LCH.