OpenMed/multicare-articles huggingface dataset:
Adventitial Cystic Disease in the Popliteal Artery Diagnosed by Intravascular Ultrasound Imaging
Authors: Eiji Miyauchi, Hideki Okui, Toshinori Yuasa, Naoya Oketani, Mitsuru Ohishi
Journal: Cureus (2023)
Keywords: cystic adventitial disease, intermittent claudication, intravascular ultrasound (ivus), pad(peripheral artery disease), popliteal artery
MeSH terms: Case Reports

The prevalence of peripheral artery disease (PAD) has been increasing in parallel with the increasing prevalence of the atherosclerotic disease. Therefore, we have to be familiar with the diagnostic approach used for ischemic symptoms in the lower limbs. Adventitial cystic disease (ACD) is rare but not negligible as one of the differential diagnoses of intermittent claudication (IC). Although duplex ultrasound and magnetic resonance imaging (MRI) are helpful tools for the diagnosis of ACD, further imaging modality is needed to avoid misdiagnosis. A 64-year-old man with a mitral valve prosthesis presented to our hospital with a one-month history of IC in the right calf after walking for approximately 50 meters. On physical examination, the pulse in the right popliteal artery was not palpable, nor were the dorsal pedis artery and posterior tibial artery, although there were no other symptoms of ischemia. His right ankle-brachial index (ABI) was 1.12 at rest but decreased to 0.50 after exercise. Three-dimensional computed tomography (CT) angiography revealed a severe stenotic lesion approximately 70 mm long in the right popliteal artery. Therefore, we diagnosed PAD in the right lower limb and planned endovascular therapy. The stenotic lesion was markedly reduced on catheter angiography when compared with CT angiography. However, intravascular ultrasound (IVUS) detected little atherosclerosis and cystic lesions within the wall in the right popliteal artery that did not involve the arterial lumen. Especially, IVUS clearly demonstrated that the crescent-shaped cyst compressed the arterial lumen eccentrically and other cysts surrounded the lumen circumferentially like petals. Because IVUS revealed these cysts to be extravascular structures, the patient was subsequently thought to have ACD of the right popliteal artery. Fortunately, his cysts reduced in size spontaneously and his symptoms disappeared. We have monitored the patient's symptoms, ABI, and findings on duplex ultrasound for seven years, during which there has been no recurrence. In this case, we diagnosed ACD in the popliteal artery by IVUS rather than duplex ultrasound and MRI.
Chromosomal 16p microdeletion in Rubinstein-Taybi syndrome detected by oligonucleotide-based array comparative genomic hybridization: a case report
Authors: Md A Mohd Fadley, Azli Ismail, Thong Meow Keong, Narazah Mohd Yusoff, Zubaidah Zakaria
Journal: J Med Case Rep (2012)

Introduction:
Chromosomal aberrations of chromosome 16 are uncommon and submicroscopic deletions have rarely been reported. At present, a cytogenetic or molecular abnormality can only be detected in 55% of Rubinstein-Taybi syndrome patients, leaving the diagnosis in 45% of patients to rest on clinical features only. Interestingly, this microdeletion of 16 p13.3 was found in a young child with an unexplained syndromic condition due to an indistinct etiological diagnosis. To the best of our knowledge, no evidence of a microdeletion of 16 p13.3 with contiguous gene deletion, comprising cyclic adenosine monophosphate-response element-binding protein and tumor necrosis factor receptor-associated protein 1 genes, has been described in typical Rubinstein-Taybi syndrome.
Case presentation:
We present the case of a three-year-old Malaysian Chinese girl with a de novo microdeletion on the short arm of chromosome 16, identified by oligonucleotide array-based comparative genomic hybridization. Our patient showed mild to moderate global developmental delay, facial dysmorphism, bilateral broad thumbs and great toes, a moderate size atrial septal defect, hypotonia and feeding difficulties. A routine chromosome analysis on 20 metaphase cells showed a normal 46, XX karyotype. Further investigation by high resolution array-based comparative genomic hybridization revealed a 120 kb microdeletion on chromosomal band 16 p13.3.
Conclusion:
A mutation or abnormality in the cyclic adenosine monophosphate-response element-binding protein has previously been determined as a cause of Rubinstein-Taybi syndrome. However, microdeletion of 16 p13.3 comprising cyclic adenosine monophosphate-response element-binding protein and tumor necrosis factor receptor-associated protein 1 genes is a rare scenario in the pathogenesis of Rubinstein-Taybi syndrome. Additionally, due to insufficient coverage of the human genome by conventional techniques, clinically significant genomic imbalances may be undetected in unexplained syndromic conditions of young children. This case report demonstrates the ability of array-based comparative genomic hybridization to offer a genome-wide analysis at high resolution and provide information directly linked to the physical and genetic maps of the human genome. This will contribute to more accurate genetic counseling and provide further insight into the syndrome.
Acute Liver Failure Requiring Liver Transplantation due to Acute Hepatitis A Virus Infection
Authors: Chencheng Xie, Jonathan M Fenkel, Dina L Halegoua-DeMarzio, Jesse M Civan, Danielle M Tholey, Steven K Herrine, Manish Thapar, Manju Ambelil, Sanaa Arastu, Adam M Frank, Ashesh P Shah, Jamie M Glorioso, Carlo G Ramirez, Adam S Bodzin, Warren R Maley, David A Sass
Journal: Case Rep Transplant (2021)
MeSH terms: Case Reports

Introduction:
Hepatitis A infection (HAV) is generally characterized by an acute icteric illness or may have a subclinical self-limited course, although rarely, can result in fulminant hepatitis and death. In 2019, the City of Philadelphia declared a public health emergency due to an HAV outbreak. We are reporting a series of four cases of acute liver failure (ALF) requiring liver transplantation (LT) due to acute HAV.
Methods:
Chart review and case descriptions of four patients with acute HAV-related ALF who were expeditiously evaluated, listed as Status 1A, and who underwent LT between August 2019 and October 2019 at Thomas Jefferson University Hospital.
Results:
All four patients presented with acute hepatocellular jaundice and had a positive HAV IgM, and all other causes of ALF were excluded. All four cases met the American Association for the Study of Liver Diseases (AASLD) criteria for ALF. Three of the four cases met King's College Criteria of poor prognosis for nonacetaminophen-induced ALF. All four patients underwent successful LT and were discharged six to twelve days postoperatively. One patient died of disseminated Aspergillus infection five months after LT, while the others have had excellent clinical outcomes shown by one-year follow-ups. All four explants had remarkably similar histological changes, revealing acute hepatitis with massive necrosis accompanied by a prominent lymphoplasmacytic inflammatory infiltrate and bile ductular proliferation.
Conclusion:
Although rare, patients presenting with acute HAV need close monitoring as they may rapidly progress to ALF. Early referral to a transplant center afforded timely access to LT and yielded overall good one-year survival. Widespread HAV vaccination for high-risk individuals is an essential strategy for preventing disease and curbing such future outbreaks.
The challenge of compassion in predator conservation
Authors: Simon Pooley
Journal: Front Psychol (2022)
Keywords: coexistence, compassion, crocodiles, ethics, human-wildlife conflict, predators

This paper argues that compassion for wild animals and the humans living alongside them should be integral to wildlife conservation. Nowhere is this more apparent than in predator conservation, and case studies are used to explore the consequences of wild animal attacks for human victims. Some arguments for extending compassionate consideration to animals seen as individuals are considered, along with the challenges these pose for predator conservation. A way forward from this apparent impasse is suggested, drawing on the capacity approach to embrace human with animal actors. The paper concludes with implications for predator conservation and recommendations, including incident responses sensitive to the traumatic impacts of attacks, and more collaborative approaches to handling human-wildlife interactions taking account of the capacities of local humans and wildlife.
Anaphylaxis triggered by benzyl benzoate in a preparation of depot testosterone undecanoate
Authors: Gregory S Y Ong, Colin P Somerville, Timothy W Jones, John P Walsh
Journal: Case Rep Med (2012)
MeSH terms: Case Reports

We report the first case of an anaphylactic reaction to Reandron 1000 (depot testosterone undecanoate with a castor oil and benzyl benzoate vehicle). While considered to have a favourable safety profile, serious complications such as oil embolism and anaphylaxis can occur. In our patient, skin testing identified benzyl benzoate to be the trigger, with no reaction to castor oil or testosterone undecanoate components. As benzyl benzoate exists in multiple pharmaceuticals, foods, and cosmetics, individual components of pharmaceuticals should be tested when investigating drug allergies. Doctors should be alert to the potential for serious reactions to any of the components of Reandron 1000.
Hairy cell leukemia: a diagnosis by endoscopic ultrasound guided fine needle aspiration
Authors: Regina S Meara, Vishnu Reddy, Juan Pablo Arnoletti, Darshana Jhala, Shyam Varadarajulu, Nirag Jhala
Journal: Cytojournal (2006)

Background:
Endosonography (EUS) guided FNA is a relatively new imaging modality which is increasingly used for sampling deep-seated lymph nodes in the diagnosis and staging of various malignancies, both primary as well as metastatic. It is also useful for staging of non-Hodgkin's lymphoma as well as diagnosing recurrence. The diagnosis of leukemia on FNA samples from deep-seated lymphadenopathy poses an even greater challenge. Hairy cell leukemia (HCL) is an uncommon, but distinct, lympho-proliferative disorder of B cell origin. It usually affects the spleen and bone marrow and uncommonly involves lymph nodes. There are only a few cases reported where HCL was diagnosed on FNA specimens.
Case presentation:
We report the first case of HCL accurately rendered on EUS-FNA samples.
Conclusion:
This report underscores the concept that the presence of a cytopathologist in the endoscopy suite plays an important role in providing accurate diagnoses of lymphoid lesions biopsied with EUS-FNA.
Traumatic Endophthalmitis due to Cellulosimicrobium cellulans
Authors: Pimkwan Jaru-Ampornpan, Anita Agarwal, Narinder K Midha, Stephen J Kim
Journal: Case Rep Ophthalmol Med (2011)
MeSH terms: Case Reports

Purpose. To report a case of traumatic endophthalmitis due to Cellulosimicrobium cellulans. Design. Case report. Methods. Retrospective chart review. Results. To our knowledge, this is the first report of traumatic endophthalmitis due to C. cellulans, which did not respond to intravitreal antibiotics or repeat vitrectomy and ultimately led to the discovery of an occult intraocular foreign body. Conclusions. C. cellulans is a rare cause of endophthalmitis. Greater awareness of this bacterium in the ophthalmic literature as a cause of endophthalmitis and its association with foreign bodies may allow earlier and more purposeful intervention in future cases.
Treatment Effect of Qingfei Paidu Decoction Combined With Conventional Treatment on COVID-19 Patients and Other Respiratory Diseases: A Multi-Center Retrospective Case Series
Authors: Xingyu Zong, Ning Liang, Jingya Wang, Huizhen Li, Dingyi Wang, Yaxin Chen, Haili Zhang, Liwen Jiao, An Li, Guihui Wu, Jike Li, Mingxuan Wang, Hongde Liu, Zhang Liu, Shusen Zhao, Jin Huang, Qiuhua Huang, Xiaoyan Wang, Jin Qin, Yan Ma, Yanping Wang, Nannan Shi
Journal: Front Pharmacol (2022)
Keywords: covid-19, qingfei paidu decoction, tcm, case series, respiratory diseases

Background: Qingfei Paidu decoction (QFPDD) has been widely used in treating coronavirus disease 2019 (COVID-19) in China. However, studies on the treatment effect of COVID-19 patients and other respiratory diseases have not been well demonstrated. Our study aims to determine the treatment effect of QFPDD in combination with conventional treatment on COVID-19 patients and other respiratory diseases. Methods: This retrospective study recruited COVID-19 patients who were treated with QFPDD for at least two courses (6 days) from seven hospitals in five provinces from January 21 to March 18 2020. Demographic, epidemiological, clinical, laboratory, computed tomography characteristics, treatment, and outcome data were collected and analyzed. The improvements in clinical symptoms before and after QFPDD treatment were compared. Results: Eight COVID-19 patients were included in this study. Of them, six were males (75.0%). The median age of the patients was 66 (60-82) years. Four patients were classified as mild and moderate cases (50.0%); there were two severe cases (25.0%) and critical cases (25.0%). The most common symptom was cough (7 [87.5%]), followed by fever (6 [75.0%]), fatigue (4 [50.0%]), asthma (4 [50.0%]), and anorexia (3 [37.5%]). Abnormal findings included decrease in neutrophils (3 [37.5%]), lymphocytes (2 [25.0%]), alkaline phosphatase (3 [37.5%]), lactic dehydrogenase (4 [50.0%]), erythrocyte sedimentation rate (2 [25.0%]), and C-reactive protein (5 [83.3%]) at admission. After one course (3 days) of QFPDD, nasal obstruction and sore throat completely disappeared, and fever (5 [83.3%]), fatigue (2 [50.0%]), and cough (2 [28.6%]) were improved. After two courses (6 days), the fever disappeared completely in all patients, and the other symptoms showed a tendency to improve. In non-severe patients, 87.5% baseline symptoms completely disappeared. In severe patients, 61.1% of the baseline symptoms completely disappeared after patients were administered QFPDD for two courses. Of the abnormal indicators, 55.6% returned to normal levels. The median duration to complete fever recovery was 1.0 day. The median durations of viral shedding and hospitalization were 10.5 and 21.5 days, respectively. None of the patients worsened and died, and no serious adverse events occurred related to QFPDD during hospitalization. Conclusion: QFPDD combined with conventional treatment improved clinical symptoms in COVID-19 patients with other respiratory diseases, and no serious adverse reactions associated with QFPDD were observed. Larger sample studies confirm our findings in the future.
Ovarian yolk sac tumour in a girl - case report
Authors: Charu Sharma, Hemanshi Shah, Neha Sisodiya Shenoy, Deepa Makhija, Mukta Waghmare
Journal: Dev Period Med (2017)
Keywords: yolk sac tumour, girl, ovary
MeSH terms: Antineoplastic Combined Chemotherapy Protocols / therapeutic use, Endodermal Sinus Tumor / diagnosis, Neoplasms, Germ Cell and Embryonal / diagnosis, Ovarian Neoplasms / diagnosis, Case Reports, Bleomycin / therapeutic use, Child, Cisplatin / therapeutic use, Endodermal Sinus Tumor / drug therapy, Endodermal Sinus Tumor / pathology, Etoposide / therapeutic use, Female, Humans, Neoplasms, Germ Cell and Embryonal / drug therapy, Neoplasms, Germ Cell and Embryonal / pathology, Ovarian Neoplasms / drug therapy, Ovarian Neoplasms / pathology, Bleomycin, Etoposide, Cisplatin, Ovarian Germ Cell Cancer

Yolk sac tumours are rare ovarian malignancies accounting for less than 1% of malignant ovarian germ cell tumours. They are mostly seen in adolescents and young women and are usually unilateral making fertility preservation imperative. Raised alpha-feto protein level is the hallmark of this tumour. We describe stage III yolk sac tumour in a girl child.
Use of a matrix for apexification procedure with mineral trioxide aggregate
Authors: Roheet A Khatavkar, Vivek S Hegde
Journal: J Conserv Dent (2010)
Keywords: apexification, artificial barrier, calcium sulfate, mineral trioxide aggregate
MeSH terms: Case Reports

This articles describes a technique for placement of a matrix barrier prior to use of mineral trioxide aggregate (MTA) as an artificial root-end barrier. The technique also demonstrates the use of a delivery system utilizing large-bore needles for the predictable and precise placement of the barrier materials at the apex of the tooth.
Hajj-related Neisseria meningitidis serogroup w135 in Mauritius
Authors: Mohammad Iqbal Issack, Chinien Ragavoodoo
Journal: Emerg Infect Dis (2002)
MeSH terms: Disease Outbreaks, Meningitis, Meningococcal / epidemiology, Neisseria meningitidis / isolation & purification, Travel, Case Reports, Adult, Cefotaxime / therapeutic use, Cephalosporins / therapeutic use, Child, Preschool, Fatal Outcome, Female, Humans, Infant, Male, Mauritius / epidemiology, Meningitis, Meningococcal / drug therapy, Middle Aged, Neisseria meningitidis / classification, Serotyping, Cephalosporins, Cefotaxime

Meningococcal disease is rare in Mauritius; only one case was reported from 1992 to 1999. However, since June 2000, four cases have occurred. Epidemiologic information and typing results indicate that these recent cases probably followed the introduction of Neisseria meningitidis W135 in Mauritius by pilgrims returning from the Hajj in 2000 and 2001.
Intra-arterial Tirofiban in a Male Nonagenarian with Acute Ischemic Stroke: A Case Report
Authors: Xianhui Ding, Ao Gu, Qian Yang, Zhiming Zhou, Xiaolei Shi
Journal: Open Life Sci (2019)
Keywords: stroke, endovascular, intra-arterial, nonagenarian, tirofiban

Nonagenarians with acute ischemic stroke tend to have a higher mortality and morbidity than younger patients. Tirofiban is a glycoprotein IIb/IIIa antagonist that has a therapeutic potential for ischemic stroke. Here, we provide a case report of a 93-year-old male patient with acute ischemic stroke. He presented with right-sided hemiparesis for 2 hours (National Institute of Health Stroke Scale, NIHSS = 23). Immediate treatment with endovascular tirofiban infusion achieved an improvement of intracranial blood flow and a progressively decreased NIHSS one day after admission (NIHSS = 16) and then seven days after admission (NIHSS = 7). After a follow-up of 90 days, the modified ranking score was 2. This case report suggests that endovascular application with tirofiban may be a favorable option for treating nonagenarians presenting with acute ischemic stroke and warrants further study.
Extraskeletal osteochondroma within the iliopsoas muscle: case report
Authors: Svetoslav Slavchev, Georgi P Georgiev
Journal: SICOT J (2017)

Osteochondromas, occurring usually in the metaphyses of long bones, are among the most frequent benign musculoskeletal neoplasms and both their sporadic and hereditary variants have been studied extensively. Extraskeletal osteochondromas, however, are much less common. They have been shown to arise near joints or synovial spaces of feet, hands, or bursae. Herein, we present a very rare case of an extraskeletal osteochondroma within the iliopsoas muscle.
Hodgkin's disease as unusual presentation of post-transplant lymphoproliferative disorder after autologous hematopoietic cell transplantation for malignant glioma
Authors: Alberto Zambelli, Daniele Lilleri, Fausto Baldanti, Mario Scelsi, Laura Villani, Gian Antonio Da Prada
Journal: BMC Cancer (2005)
MeSH terms: Glioma / therapy, Hematopoietic Stem Cell Transplantation / adverse effects, Hodgkin Disease / diagnosis, Lymphoproliferative Disorders / etiology, Transplantation, Homologous / adverse effects, Case Reports, Research Support, Non-U.S. Gov't, Adrenal Cortex Hormones / therapeutic use, Antineoplastic Agents / therapeutic use, Glioma / complications, Humans, Lymphatic Metastasis, Male, Middle Aged, Adrenal Cortex Hormones, Antineoplastic Agents

Background:
Post-transplant lymphoproliferative disorder (PTLD) is a complication of solid organ and allogeneic hematopoietic stem cell transplantation (HSCT); following autologous HSCT only rare cases of PTLD have been reported. Here, a case of Hodgkin's disease (HD), as unusual presentation of PTLD after autologous HSCT for malignant glioma is described.
Case presentation:
60-years old man affected by cerebral anaplastic astrocytoma underwent subtotal neurosurgical excision and subsequent high-dose chemotherapy followed by autologous HSCT. During the post HSCT course, cranial irradiation and corticosteroids were administered as completion of therapeutic program. At day +105 after HSCT, the patient developed HD, nodular sclerosis type, with polymorphic HD-like skin infiltration.
Conclusion:
The clinical and pathological findings were consistent with the diagnosis of PTLD.
Neoadjuvant Four-Drug Combination Therapy for NSCLC With EGFR Mutation Avoiding Total Pneumonectomy
Authors: Jingpei Li, Ke Xu, Weipeng Cai, Yalei Zhang, Xin Zeng, Fei Cui, Zhexue Hao, Jun Liu, Jianxing He
Journal: Front Oncol (2020)
Keywords: egfr mutation, chemothearpy, neoadjuvant, surgery, targeted (selective) treatment
MeSH terms: Case Reports

We report a case of successful neoadjuvant four-drug combination therapy to avoid total pneumonectomy. A 33-year-old male patient was diagnosed with locally advanced non-squamous NSCLC harboring EGFR mutation in the left lower lobe. The patient experienced significant clinical downstaging after two cycles of neoadjuvant therapy, including icotinib, carboplatin, pemetrexed, and bevacizumab. He underwent a successful lobectomy avoiding pneumonectomy. The patient showed no recurrence in the follow-up of a chest computed tomographic scan, which is 17 months after surgery. The promising results of this neoadjuvant combination therapy provided a novel therapeutic option for patients with locally advanced EGFR-mutated NSCLC facing total pneumonectomy.
A Modified Reverse Remplissage Procedure for Management of a Locked Posterior Shoulder Dislocation
Authors: Xavier Zwiebel, Stéphane Pelet, Alexandre Leclerc
Journal: Case Rep Orthop (2020)
MeSH terms: Case Reports

Posterior shoulder dislocation is rare and often represents a diagnostic and therapeutic challenge. An impaction fracture of the anteroinferior aspect of the humeral head (called a reverse Hill-Sachs (RHS) fracture) is always present in case of chronic locked posterior dislocation. Surgical management is required and decided on the delay between the trauma and the diagnosis and the importance of the RHS (in percentage). The authors present a chronic locked posterior shoulder dislocation in a 32-year-old active male with a reverse Hill-Sachs lesion of more than 40%. An open reduction was required, and stabilization was achieved with a modified remplissage technique with detachment of the upper quarter of the subscapularis tendon. Three years after the surgery, the patient recovered an excellent functional level with a stable shoulder.