OpenMed/multicare-articles huggingface dataset:
Evaluation of Retinal Changes Using Optical Coherence Tomography in a Pediatric Case of Susac Syndrome
Authors: Mehmet Kola, Hidayet Erdöl, Sevil Ertuğrul Atasoy, Adem Türk
Journal: Turk J Ophthalmol (2017)
Keywords: retina, susac syndrome, diagnosis, optical coherence tomography, retinal artery occlusion

Susac syndrome is a rare occlusive vasculopathy affecting the retina, inner ear and brain. The cause is unknown, although it generally affects young women. This syndrome can be difficult to diagnose because its signs can only be revealed by detailed examination. These signs are not always concomitant, but may appear at different times. This report describes a pediatric case who was diagnosed with Susac syndrome when retinal lesions were identified in the inactive period with the help of optical coherence tomography (OCT). The purpose of this case report is to emphasize the importance of OCT in clarifying undefined retinal changes in Susac syndrome.
Self-expanding metal stent restenosis in obstructive colon diverticulitis mimicking colon cancer: A case report
Authors: Ryo Ohta, Ryota Sakon, Manabu Goto, Yuji Tachimori, Koji Sekikawa
Journal: Int J Surg Case Rep (2018)
Keywords: benign colorectal obstruction, case report, in-stent restenosis, self-expanding metal stent

Introduction:
The self-expanding metal stent (SEMS) has been used in malignant colorectal obstruction as a bridge to surgery or for palliative treatment. We report a case of obstructive descending colon diverticulitis in-stent restenosis, which is difficult to distinguish from colon cancer.
Presentation of case:
A 48-year-old man presented with abdominal pain. Computed tomography demonstrated a segment of thickened wall in the descending colon with near-complete obstruction. Colonoscopy revealed stenosis over the entire circumference of the descending colon. Biopsy revealed no malignant findings. SEMS was inserted to improve bowel obstruction. However, bowel obstruction did not improve, and stent-in-stent insertion was performed. Because colon cancer could not be completely excluded, left hemicolectomy with lymph node dissection was performed. The pathological examination revealed colon diverticulitis and no malignant finding.
Discussion:
Benign colorectal diseases can present with symptoms similar to those of obstructive colorectal cancer. As a result, it was benign colorectal stenosis, but it was thought that resection should be considered when the malignant lesion is suspected. The use of SEMS in benign colorectal disease has been reported a few. Reinsertion of the stent for restenosis, in bridge to surgery, was also considered useful from the viewpoint of avoiding emergent operation and reducing complications.
Conclusion:
For colon stenosis suspected of malignant disease, it was thought that resection by inserting SEMS should be taken into consideration even for benign disease as a result.
Applying social life cycle assessment to evaluate the use phase of mobility services: a case study in Berlin
Authors: Katharina Gompf, Marzia Traverso, Jörg Hetterich
Journal: Int J Life Cycle Assess (2022)
Keywords: case study, mobility services, s-lca, social life cycle assessment, social sustainability indicators, use phase

Purpose:
The main purpose of this S-LCA case study is to analyse social impacts of the use phase of mobility services is a holistic way, taking into account positive as well as negative impacts. The use phase plays an important role for the assessment of services, which is why this study exclusively focuses on the use phase assessment. That way, this study aims to contribute to answer the question whether mobility services can improve quality of life in cities.
Methods:
For the analysis, seven different mobility options were chosen in the city of Berlin, Germany, including free-floating car sharing, e-scooter sharing, S-Bahn, subway, tram, bus and the car in private ownership. For the analysis, five stakeholder groups that are outlined in the S-LCA Guidelines (UNEP 2020) were taken into account: Local Community, Consumer, Worker, Value Chain Actors and Society. For a detailed analysis of all relevant aspects, 37 indicators were analysed, out of which 23 are quantitative and 14 are qualitative. For data collection, several different data sources were used, including publicly available data e.g. from statistics as well as own data from interviews.
Results and discussion:
For comparability, all results are displayed on a 5-point scale from - 2 to + 2, in line with the Handbook (Goedkoop et al. 2018) and the S-LCA Guidelines (UNEP 2020). For some indicators, the results of the case study are as expected, for example regarding impacts on air quality. For other indicators, however, the results are specific for the analysed mobility services in Berlin and therefore give new insights and reveal new aspects, as for example in the case of job creation for the local community. The main challenge of this S-LCA case study was data availability and data quality, which is why assumptions and simplifications had to be made, especially regarding space occupancy and the allocation of common infrastructure.
Conclusions:
This S-LCA case study provides a holistic assessment of the use phase of mobility services, taking into account five stakeholder categories and their respective social impacts. The study illustrates specific results for the city of Berlin, showing positive as well as negative social impacts of mobility services and outlines a procedure for further studies. That way, this case study contributes to answer the overlying question whether mobility services can improve quality of life in cities.
Supplementary information:
The online version contains supplementary material available at 10.1007/s11367-022-02051-y.
Management of Traumatic Injury to Maxillary Central Incisors associated with Inverted Mesiodens: A Case Report
Authors: Chaitanya Pavuluri, Sivakumar Nuvvula
Journal: Int J Clin Pediatr Dent (2013)
Keywords: apexification, inverted supernumerary tooth, maxillary central incisor, mineral trioxide aggregate
MeSH terms: Case Reports

Maxillary incisors are the most frequently injured teeth in the primary and permanent dentition. Stage of adolescence show a significant number of dental injuries as they engage in contact sports. Children with accident prone profile, i.e. class II division I or class I type II malocclusion are more prone for injuries because of the proclined maxillary incisors. Supernumerary teeth are those that are additional to the normal complement. They occur in single or multiple, unilateral or bilateral in either of the jaws. This paper reports the presence of an inverted supernumerary tooth in the right maxillary central incisor region with trauma involving both maxillary central incisors and also the management of the supernumerary tooth and traumatized teeth in a 14-year-old boy. How to cite this article: Pavuluri C, Nuvvula S. Management of Traumatic Injury to Maxillary Central Incisors associated with Inverted Mesiodens: A Case Report. Int J Clin Pediatr Dent 2013;6(1):30-32.
Voice Recovery in a Patient with Inhaled Laryngeal Burns
Authors: Geun-Hyo Kim, Soo-Geun Wang, Yeon-Woo Lee, Soon-Bok Kwon
Journal: Iran J Otorhinolaryngol (2019)
Keywords: dysphonia, inhalation burns, laryngoscopy, larynx
MeSH terms: Case Reports

Introduction:
Laryngeal burns cause long-term voice disorders due to mucosal changes of the vocal folds. Inhalation injuries affect voice production and result in changes in the mucosal thickness and voice quality.
Case report:
A 47-year-old woman was transferred to our department with laryngeal burns sustained during a house fire. On laryngoscopic examination, mucosal waves of both vocal folds were not visualized due to the injury caused by inhalation of high-temperature toxic smoke. Hence, voice analysis, laryngoscopic examinations, and high-speed videoendoscopy (HSV) were performed to evaluate vocal fold vibrations. An absence of mucosal waves and a breathy and strained voice with a severe grade were noted. We report that voice quality was recovered to close to the normal state through multiple treatments such as medication, voice therapy, and counseling.
Conclusion:
This paper presents the unique case of a patient with laryngeal burns, in which vibrations of the vocal folds were observed using laryngoscopic examination and HSV. Voice samples before and after treatment were also analyzed. By observing the vibration pattern of the injured vocal fold, it is expected that appropriate diagnosis and treatment planning can be established in clinical practice.
Isolated Horizontal Gaze Palsy: Observations and Explanations
Authors: Renee Ewe, Owen B White, Ailbhe Burke
Journal: Front Neurol (2017)
Keywords: horizontal gaze, median longitudinal fasciculus, ophthalmoplegia, paramedian pontine reticular formation, pontine anatomy
MeSH terms: Case Reports

We present three cases that we suggest require a novel diagnosis and a reconsideration of current understandings of pontine anatomy. In this case series, we highlight a series of patients with monophasic, fully recovering inflammatory lesions in the pontine tegmentum not due to any of the currently recognized causes of this syndrome. We highlight other similar cases in the literature and suggest there may be a particular epitope for an as-yet-undiscovered antibody underlying the tropism for this area. We highlight the potential harm of misdiagnosis with relapsing inflammatory or other serious diagnoses with significant adverse impact on the patient. In addition, we propose that this would support a reinterpretation of the currently accepted anatomy of the pontine gaze inputs to the median longitudinal fasciculus and paramedian pontine reticular formation.
A Case of Severe Acute Kidney Injury Exacerbated by Canagliflozin in a Patient with Type 2 Diabetes
Authors: Kimya Hassani-Ardakania, Mark L Lipman, Denny Laporta, Oriana Hoi Yun Yu
Journal: Case Rep Endocrinol (2019)
MeSH terms: Case Reports

Background:
Sodium glucose cotransport (SGLT)-2 inhibitors are the newest class of antihyperglycemic agents used as second- or third-line treatment in the management of type 2 diabetes. Although the use of SGLT-2 inhibitors has not been shown to cause nephrotoxicity, there have been case reports of SGLT-2 inhibitor use being associated with acute kidney injury.
Case presentation:
A 72-year-old woman with a history of type 2 diabetes and no known chronic renal insufficiency presented to the emergency room with a 3-day history of nausea, vomiting, and increased somnolence. She was found to have potassium level of 7.4 (normal: 3.5-5.5) mmol/L and a markedly elevated creatinine level at 1154 (normal: 45-95) μmol/L. Imaging of the abdomen and pelvis did not reveal any findings of obstruction. Urine microscopy showed many granular casts. In the absence of other causes for her clinical presentation, the patient was diagnosed with acute kidney injury secondary to ischemic acute tubular necrosis, with canagliflozin use likely an important contributing factor.
Conclusions:
Physicians should inform patients to stop the use of SGLT-2 inhibitors when patients are unable to maintain hydration or during acute illness. Use of SGLT-2 inhibitors in managing type 2 diabetes should be done with caution among more vulnerable populations, including individuals with cognitive impairment and the elderly.
Guillain-Barré Syndrome in Patient With SARS-CoV-2 PCR Positivity Treated Successfully With Therapeutic Exchange Plasma: A First Case Report From Vietnam
Authors: Sy Duong-Quy, Duc Huynh-Truong-Anh, Thanh Nguyen-Thi-Kim, Tien Nguyen-Quang, Thanh Nguyen-Chi, Quynh Tran-Xuan, Vinh Nguyen-Nhu, Carine Ngo, Timothy Craig
Journal: Front Neurol (2022)
Keywords: covid-19, guillain-barré syndrome, mrc scale, sars-cov-2, therapeutic plasma exchange
MeSH terms: Case Reports

Since the first case of Guillain-Barré syndrome (GBS)-associated SARS-CoV-2 (COVID-19) infection reported in 2020, a series of cases have been published in some countries. In this case report, we present a young patient with GBS, whose clinical and laboratory data were appropriate for the diagnosis of GBS due to COVID-19 infection. Neurological examination revealed the muscular weakness of lower limbs with Medical Research Council (MRC) scale of 2/5 associated with diminished reflexes. Laboratory studies showed the positive nasal swab RT-PCR test for COVID-19, leukopenia, increased ferritin and LDH levels, normal electrolyte and liver and kidney function, and normal chest X-ray. The result of cerebrospinal fluid showed the albuminocytologic dissociation. The patient was treated with remdesivir, dexamethasone, anticoagulation, and therapeutic plasma exchange (TPE). Patient's muscle weakness was significantly improved after 1 week of admission. He was discharged at 23rd days of hospitalization and followed-up in the out-patients department.
Pediatric naso-sinusal inverted papilloma: report of a case and literature review
Authors: Amel El Korbi, Sondes Jellali, Naourez Kolsi, Rachida Bouatay, Leila Njim, Emna Berguaoui, Mehdi Ferjaoui, Khaled Harrathi, Jamel Koubaa
Journal: Pan Afr Med J (2020)
Keywords: inverted, case report, endoscopic surgery, papilloma, pediatric
MeSH terms: Nose Neoplasms / diagnosis, Papilloma, Inverted / diagnosis, Case Reports, Review, Biopsy, Child, Humans, Male, Nose Neoplasms / pathology, Nose Neoplasms / therapy, Papilloma, Inverted / pathology, Papilloma, Inverted / therapy, Paranasal Sinus Neoplasms / diagnosis, Paranasal Sinus Neoplasms / pathology, Paranasal Sinus Neoplasms / therapy

Inverted papilloma is a rare nasosinusal tumor that mainly occurs in adults during the 5th decade. The occurrence in children is exceptional and only few cases have been reported in the litterature. Clinical and radiological findings mimic other benign nasosinusal pathologies; therefore, diagnosis is based on histopathology either via biopsy or following surgical excision. Here we present a rare case of pediatric inverted papilloma in a 11-year-old child and we discuss clinical, radiological, therapeutic and evolutionary features through a literature review.
Long-term Remission Over Six Years for a Patient with Recurrent Glioblastoma Treated with Cediranib/Lomustine
Authors: Doniel Drazin, Lutfi Al-Khouja, Ashish Patel, Jethro Hu, Surasak Phuphanich
Journal: Cureus (2016)
Keywords: neurosurgery, brain tumor, glioblastoma multiforme, recurrent glioblastoma
MeSH terms: Case Reports

Cediranib is an orally available, pan-VEGFR tyrosine kinase inhibitor. A previous Phase III study of patients with recurrent glioblastoma treated with this drug did not meet the primary end of progressive-free survival (PFS). We identified one patient, a 57-year-old Caucasian female who, following surgery in October 2008 and concurrent temozolomide and radiation therapy from November 8, 2008, to January 6, 2009, developed a tumor progression of the left posterior frontal measuring 1.2 x 1.5 cm in February 2009. She was enrolled in a randomized, Phase III, placebo-controlled, partially-blinded clinical trial of cediranib as either monotherapy or in combination with lomustine (CCNU) versus CCNU. She was randomized to receive a combination therapy with 1st cycle CCNU 190 mg and cediranib 20 mg per day on April 15, 2009. However, she developed nephrotic syndrome and uncontrolled hypertension and was taken off this study in May 2010. Her six-week MRI showed a 50% tumor regression and a complete response at twenty-four weeks. With no enhancement seen on MRI on June 4, 2015, she has been off therapy and in clinical remission over five years with high functional level and good quality of life (KPS-90%). This is a case report of successful therapy for recurrent glioblastoma with long-term remission despite termination of therapy greater than six years from cediranib and limited CCNU dosage.
Percutaneous placement of the peripheral catheter to the subclavian vein for a VA shunt
Authors: Drosos Evangelos, Giakoumettis Dimitrios, Sfakianos Georgios, Eleftherakis Nikolaos, Papadopoulos Filippos, Themistocleous Marios
Journal: Pan Afr Med J (2017)
Keywords: ventriculo-atrial shunt, hydrocephalus, percutaneous, subclavian vein
MeSH terms: Catheterization / methods, Cerebrospinal Fluid Shunts / methods, Hydrocephalus / surgery, Case Reports, Catheters, Child, Preschool, Equipment Failure, Humans, Male, Reoperation, Subclavian Vein, Ventriculoperitoneal Shunt / methods

Hydrocephalus is a common neurosurgical pathology that affects people of all ages and especially the pediatric population. It can be very often a life threatening condition that pediatric neurosurgeons must deal with. Therefore a number of CSF diversion techniques have been established. The gold standard treatment currently is the placement of a ventriculo-peritoneal shunt. Because of hydrocephalus being a lifelong condition, it is almost in daily practice dealing with cases of shunt failures for a number of reasons. Herewith we present a 4 year old child with multiple ventriculo-peritoneal shunt revision surgeries and ventriculo-atrial failure due to distal catheter malfunction that was treated with percutaneous placement of the peripheral catheter in the subclavian vein.
Case Report: Central Retinal Artery Occlusion in a COVID-19 Patient
Authors: Andrea Montesel, Claudio Bucolo, Victoria Mouvet, Emmanuelle Moret, Chiara M Eandi
Journal: Front Pharmacol (2020)
Keywords: sars-cov-2, case report, central retinal artery occlusion, coronavirus disease-2019, severe acute respiratory syndrome coronavirus 2, thrombosis
MeSH terms: Case Reports

We report a case of central retinal artery occlusion (CRAO) in a patient with a previous history of severe COVID-19 disease. This disease has been associated with inflammatory-induced homeostasis changes leading to endothelial dysfunction and a procoagulant state with multi-organ involvement, but the burden of thromboembolic complications in COVID-19 patients is currently unknown. The pathogenesis of retinal artery occlusions is a multifactorial process where inflammation and hypercoagulation state are established risk factors. Even if our experience may represent a coincidental relationship, it is likely that COVID-19 patients could be at risk of developing retinal vascular occlusions. A focused ophthalmological surveillance is advisable to prevent and manage this possible cause of severe vision loss that has an important impact in health care system.
Successful Treatment of Gastric Relapse in Multiple Myeloma with Bortezomib after Autologous Hematopoietic Stem Cell Transplantation (autoHSCT)
Authors: Serdar Sivgin, Suleyman Baldane, Leylagul Kaynar, Fatih Kurnaz, Mevlut Baskol, Mustafa Kula, Celalettin Eroglu, Kemal Deniz, Bulent Eser, Ali Unal, Mustafa Cetin
Journal: Mediterr J Hematol Infect Dis (2013)
MeSH terms: Case Reports

We report a case of 59-year-old Turkish man with history of mitral valve replacement (MVR) and chronic obstructive pulmonary disease (COPD) who was diagnosed with stage IIIA IgG lambda multiple myeloma (MM) in 1997. He underwent autologous hematopoietic stem cell transplantation after a conditioning regimen with melphalan 200mg per body area (m(2)) in February 2006. On February 2011, he was admitted to the emergency service of university hospital with complaints of hematemesis and melena. Pathological evaluation of gastric biopsy, obtained from a lesion of small gastric curvature, showed the gastric mucosa infiltrated by neoplastic plasma cells, monoclonal lambda light chain positive. The patient was considered as having local gastric relapsed disease and was treated with 2 cycles of bortezomib. He achieved an excellent local response after 2 cycles of bortezomib, cyclophosphamide and prednisone (BEP) regimen, with healing of gastric ulcer and no recurrence of the hematemesis or melena.
Prolonged Fever; a Case Report of Medical Malpractice
Authors: Fares Najari, Nasser Malekpour-Alamdari, Ideh Baradaran Kial, Dorsa Najari, Sahar Mirzaei
Journal: Arch Acad Emerg Med (2021)
Keywords: catheters, catheterization, central venous, fever, foreign bodies, malpractice, renal dialysis
MeSH terms: Case Reports

Any surgical or preoperative treatment and diagnostic procedure may be associated with complications and risks. Therefore, introduction of complicated cases plays an important role in educating those involved in the diagnosis of patients. Generally, if a physician or a nurse is informed that an item is inadvertently left behind in a patient's body during surgery, he/she is obliged to take action by notifying the healthcare system authorities and informing the patient as soon as possible; otherwise, he/she has committed a disciplinary violation. Here we present a 27-year-old female patient with a history of renal failure with prolonged fever following a retained Shaldon catheter in a patient's chest.
Intellectual disability-associated gain-of-function mutations in CERT1 that encodes the ceramide transport protein CERT
Authors: Hiroaki Murakami, Norito Tamura, Yumi Enomoto, Kentaro Shimasaki, Kenji Kurosawa, Kentaro Hanada
Journal: PLoS One (2020)
MeSH terms: Gain of Function Mutation, Intellectual Disability / genetics, Protein Serine-Threonine Kinases / genetics, Case Reports, Research Support, Non-U.S. Gov't, Cells, Cultured, Female, HCT116 Cells, Humans, Intellectual Disability / pathology, Protein Domains, Protein Serine-Threonine Kinases / chemistry, Protein Serine-Threonine Kinases / metabolism, Young Adult, CERT1 protein, human, Protein Serine-Threonine Kinases

Intellectual disability (ID) is a developmental disorder that includes both intellectual and adaptive functioning deficits in conceptual, social, and practical domains. Although evidence-based interventions for patients have long been desired, their progress has been hindered due to various determinants. One of these determinants is the complexity of the origins of ID. The ceramide transport protein (CERT) encoded by CERT1 mediates inter-organelle trafficking of ceramide for the synthesis of intracellular sphingomyelin. Utilizing whole exome sequencing analysis, we identified a novel CERT variant, which substitutes a serine at position 135 (S135) for a proline in a patient with severe ID. Biochemical analysis showed that S135 is essential for hyperphosphorylation of a serine-repeat motif of CERT, which is required for down-regulation of CERT activity. Amino acid replacements of S135 abnormally activated CERT and induced an intracellular punctate distribution pattern of this protein. These results identified specific ID-associated CERT1 mutations that induced gain-of-function effects on CERT activity. These findings provide a possible molecular basis for not only new diagnostics but also a conceivable pharmaceutical intervention for ID disorders caused by gain-of-function mutations in CERT1.