OpenMed/multicare-articles huggingface dataset:
Multicentric Carpo-Tarsal Osteolysis
Authors: Lea Tannouri, Paolo Simoni
Journal: J Belg Soc Radiol (2023)
Keywords: children, jia, joints
MeSH terms: Case Reports

MCTO is a rare autosomal-dominant inherited disorder that causes bone destruction and deformity of the appendicular bones in children, with the carpal and tarsal bones severely affected. Imaging can narrow the differential diagnosis between MTCO and other diseases that cause osteolysis of the joints in children. The MCTO diagnosis is confirmed by a mutation of the MAFB gene.
Teaching point:
Multicentric carpo-tarsal osteolysis (MTCO) in childhood must be considered in the differential diagnosis of severe osteolysis on radiographs.
Rapidly Fatal Postlaparoscopic Liver Infection from the Rarely Isolated Species Clostridium butyricum
Authors: Kenneth L Muldrew
Journal: Case Rep Infect Dis (2020)
MeSH terms: Case Reports

We report a case of a rapidly fatal postlaparoscopic cholecystectomy liver infection from the rarely isolated species Clostridium butyricum. Liver examination at autopsy showed cystic spaces, necrosis, and spore-forming Gram-positive rods. 16sRNA gene sequencing of the cystic liver tissue identified the organism as C. butyricum.
Delayed postoperative spinal epidural hematoma after anterior cervical discectomy and fusion: A case report
Authors: Wenbin Xu, Jiandong Guo, Jinjin Zhu, Xing Zhao, Iranmanesh Yasaman, Jian Chen, Jiying Wang, Shunwu Fan, Xiangqian Fang
Journal: Front Surg (2022)
Keywords: anterior cervical discectomy, anterior cervical discectomy and fusion, spinal epidural hematoma, spine, surgery
MeSH terms: Case Reports

Background:
Postoperative spinal epidural hematoma (POSEH) causes rapid neurological deficits within 24 h following the operation and can be fatal. However, some POSEH symptoms manifest three days after the operation, also known as delayed POSEH (DPOSEH). Little attention has been provided upon DPOSEH owing to its rare incidence, resulting in serious consequences upon occurrence. To date, no cases of delayed POSEH after anterior cervical surgery have been reported.
Case presentation:
We describe a case of DPOSEH that presented with delayed neurological deficits on the fifth day after anterior cervical discectomy and fusion (ACDF) surgery. Methylprednisolone was administered but showed no efficacy. MR revealed low T1 and strip long T2 signals located behind discs. After emergency surgical decompression, the patient's muscle strength returned to the preoperative state. However, his muscle strength decreased again on the seventh postoperative day, and the patient's family refused further surgery. Nine months after ACDF, the patient died of septic shock and respiratory failure.
Conclusions:
DPOSEH can occur after three days or more following anterior cervical surgery; hence, monitoring of neurological function is suggested to be extended. Complete evaluation of risk factors, timely recognition, and differentiation of neurological symptoms are required for spine surgery. In the case of DPOSEH, methylprednisolone can be administered reasonably during the transition period. However, if there is no resolution of symptoms, emergency surgery should be performed as soon as possible.
Beta-lactam antibiotics as a possible novel therapy for managing epilepsy and autism, a case report and review of literature
Authors: Ahmad Ghanizadeh, Michael Berk
Journal: Iran J Child Neurol (2015)
Keywords: antibiotic, cefixime, glutamate, inflammation, therapy, transporter
MeSH terms: Case Reports

Autism is a disorder of unknown etiology. There are few FDA approved medications for treating autism. Co-occurring autism and epilepsy is common, and glutamate antagonists improve some symptoms of autism. Ceftriaxone, a beta-lactam antibiotic, increases the expression of the glutamate transporter 1 which decreases extracellular glutamate levels. It is hypothesized that modulating astrocyte glutamate transporter expression by ceftriaxone or cefixime might improve some symptoms of autism. This case report of a child with autism and epilepsy suggests a decrease in seizures after taking cefixime.
A next-generation marker genotyping platform (AmpSeq) in heterozygous crops: a case study for marker-assisted selection in grapevine
Authors: Shanshan Yang, Jonathan Fresnedo-Ramírez, Minghui Wang, Linda Cote, Peter Schweitzer, Paola Barba, Elizabeth M Takacs, Matthew Clark, James Luby, David C Manns, Gavin Sacks, Anna Katharine Mansfield, Jason Londo, Anne Fennell, David Gadoury, Bruce Reisch, Lance Cadle-Davidson, Qi Sun
Journal: Hortic Res (2016)

Marker-assisted selection (MAS) is often employed in crop breeding programs to accelerate and enhance cultivar development, via selection during the juvenile phase and parental selection prior to crossing. Next-generation sequencing and its derivative technologies have been used for genome-wide molecular marker discovery. To bridge the gap between marker development and MAS implementation, this study developed a novel practical strategy with a semi-automated pipeline that incorporates trait-associated single nucleotide polymorphism marker discovery, low-cost genotyping through amplicon sequencing (AmpSeq) and decision making. The results document the development of a MAS package derived from genotyping-by-sequencing using three traits (flower sex, disease resistance and acylated anthocyanins) in grapevine breeding. The vast majority of sequence reads (⩾99%) were from the targeted regions. Across 380 individuals and up to 31 amplicons sequenced in each lane of MiSeq data, most amplicons (83 to 87%) had <10% missing data, and read depth had a median of 220-244×. Several strengths of the AmpSeq platform that make this approach of broad interest in diverse crop species include accuracy, flexibility, speed, high-throughput, low-cost and easily automated analysis.
Congenital intranasal glioma
Authors: Sajad Ahmad Salati, Ajaz Ahmad Rather
Journal: Case Rep Surg (2011)
MeSH terms: Case Reports

Congenital midline swellings of nose are encountered rarely, and nasal gliomas constitute about 5% of such lesions. Various theories have been suggested to explain the pathogenesis. Imaging preferably by MRI is mandated to study the extent and to rule out intracranial extension. Treatment is complete excision, and the approach depends upon the extent of the lesion and availability of expertise. We present the management of one such case of congenital intranasal glioma without any intracranial extension that presented as a septal polyp.
Case Report of Presumed (In)voluntary Capsaicin Intoxication Mimicking an Acute Abdomen
Authors: Simona Koprdova, Christine Schürmann, Dirk Peetz, Thomas Dürbye, Frank Kolligs, Herbert Koop
Journal: Case Rep Med (2020)
MeSH terms: Case Reports

Background:
The clinical features of a presumed capsaicin intoxication have not been reported so far. Case Presentation. A 27-year-old man took part in a qualifying for a competition in spicy food tolerance. During this qualifying, he swallowed 4 chili peppers type Bhut jolokia (about 1 million Scoville units) and other extremely spicy foods; the total amount of capsaicin ingested (roughly calculated retrospectively) accounted for at least 600 mg. After 2½ hours, the patient developed severe abdominal pain, which led to hospital admission. In contrast to the severe symptoms, clinical, laboratory, and imaging examinations (ultrasound and plain X-ray of the abdomen) did not reveal any significant abnormalities. Treatment with analgesics resulted in complete regression of the abdominal pain within 30 hours.
Conclusions:
The clinical picture in the view of pharmacological investigations on intestinal capsaicin infusions suggests that excessive doses of capsaicin can induce severe abdominal pain; the prolonged symptoms were probably due to the failure to vomit. Thus, a capsaicin intoxication must be considered in the differential diagnosis of an acute abdomen.
Plasmodium malariae in Bangladesh
Authors: W Rahman, K Chotivanich, K Silamut, N Tanomsing, A Hossain, M A Faiz, A M Dondorp, R J Maude
Journal: Trans R Soc Trop Med Hyg (2010)
MeSH terms: Malaria / parasitology, Plasmodium malariae / isolation & purification, Case Reports, Research Support, Non-U.S. Gov't, Adult, Antimalarials / administration & dosage, Bangladesh, Humans, Malaria / drug therapy, Male, Polymerase Chain Reaction, Quinine / administration & dosage, Rosette Formation, Treatment Outcome, Antimalarials, Quinine

We describe a 32-year-old Bangladeshi male presenting with severe malaria caused by a mono-infection with Plasmodium malariae. Rosetting of infected and uninfected erythrocytes, a putative virulence factor in falciparum malaria, was observed in the blood slide. Severe disease caused by P. malariae is extremely rare. The patient made a rapid recovery with intravenous quinine treatment.
Case Report: Kikuchi: The great mimicker
Authors: Kevin Bryan Lo, Anna Papazoglou, Lorayne Chua, Nellowe Candelario
Journal: F1000Res (2018)
Keywords: kikuchi, autoimmune, fever, lymphadenitis
MeSH terms: Histiocytic Necrotizing Lymphadenitis / diagnosis, Case Reports, Biopsy, Diagnosis, Differential, Female, Glucocorticoids / therapeutic use, Histiocytic Necrotizing Lymphadenitis / blood, Histiocytic Necrotizing Lymphadenitis / diagnostic imaging, Histiocytic Necrotizing Lymphadenitis / drug therapy, Humans, Prednisone / therapeutic use, Tomography, X-Ray Computed, Young Adult, Glucocorticoids, Prednisone

Kikuchi-Fujimoto disease is a form of a benign necrotizing lymphadenitis which is most commonly misdiagnosed as tuberculosis and or lymphoma, usually more common among young adults in Asia. It is a benign disease but can mimic a lot of other disease processes spanning infectious, rheumatologic and even hematologic malignancies. Our patient presented with prolonged fever and lymphadenopathy. Initial considerations were lymphoma and a nonspecific viral infection. A CT scan showed diffuse cervical lymphadenopathy with lacrimal gland involvement. An excisional lymph node biopsy was done which revealed Kikuchi disease. Patient was given steroids with immediate response with defervescence. Kikuchi is a disease with many mimics and a complete workup is needed to exclude serious disease like malignancy.
Social and Psychological Capital for the Start-Up of Social Enterprises With a Migratory Background
Authors: Camilla Modesti, Alessandra Talamo, Giampaolo Nicolais, Annamaria Recupero
Journal: Front Psychol (2020)
Keywords: entrepreneurship, psychological capital, refugee, social capital, social integration

The highest number of forcibly displaced people has been currently recorded due to war, poverty, and climate change. Recently, a process that recognizes refugees as reliable interlocutors for the improvement of reception policies has started. Refugees are therefore encouraged to start up social enterprises aimed at fostering newcomers' social integration to participate to such a phenomenon. Positive Psychology, with its focus on human strengths, allows to identify the resources that pushed refugees to turn the difficulties they faced during the journey and the resettlement process into resources for themselves and for the resettlement community. The following paper explores in particular the interplay between social and psychological capital that is at the base of a similar social entrepreneurship project through a case study. A qualitative research has been carried out within a social enterprise with a migratory background to analyze the internal and relational resources that brought founders to start up the venture. Results show that while social and psychological capital were independently activated to start from scratch in the resettlement community, they occurred in interrelation in a subsequent phase when participants transformed their direct experiences related to migration into the human capital of their enterprise.
Supraglottic Foreign Body Missed for One Month in a Child
Authors: Mohamed Iliyas Sultan Abdul Kader, Nadia Syafeera, Khadijah Md Nor, Saraiza Abu Bakar, Marina Mat Baki
Journal: Cureus (2023)
Keywords: aspiration, delayed diagnosis, foreign body, hoarseness, pediatric laryngology
MeSH terms: Case Reports

Foreign body (FB) aspiration in children can result in serious complications that can lead to even death. We present a case of a one-year-old girl child with a history of choking one month prior while she was feeding. A bolus of rice was removed at a local clinic. Consequently, within 24 hours, she developed hoarseness and noisy breathing which was treated as an upper respiratory tract infection at two different clinics. This case report aims to highlight the need for otolaryngology consultation in a child with non-resolving respiratory symptoms following episodes of choking. This will prompt an immediate surgical intervention that could prevent potential morbidity and mortality as a result of a compromised airway.
A Novel BLNK Gene Mutation in a Four-Year-Old Child Who Presented with Late Onset of Severe Infections and High IgM Levels and Diagnosed and Followed as X-Linked Agammaglobulinemia for Two Years
Authors: Ezgi Topyildiz, Neslihan Edeer Karaca, Ayse Aygun, Ayca Aykut, Asude Durmaz, Guzide Aksu, Necil Kutukculer
Journal: Case Reports Immunol (2022)
MeSH terms: Case Reports

Agammaglobulinemia is a rare inherited immunodeficiency disorder. Mutations in the BLNK gene cause low levels of mature B lymphocytes in the peripheral blood leading to recurrent infections. We present a four-year-old Turkish boy who had recurrent respiratory tract infections in the last six months. He had very low IgG (81 mg/dl) and IgA levels (<5 mg/dl) with high IgM (258 mg/dl). Flow cytometric analysis of lymphocyte subsets showed low CD19+ B cells (0.05%). Homozygous c.790C > T (p.Gln264Ter) mutation was detected in the BLNK gene with Targeted Next Generation Sequencing (TNGS) gene analysis. Agammaglobulinemia may be due to different genetic etiologies together with complex genetic events. Although the first diagnosis to be considered in male patients is Bruton's agammaglobulinemia, patients with normal BTK sequence and/or expression should be investigated with a large genetic study such as TNGS in the early period to reach a definitive diagnosis. This male case of agammaglobulinemia highlights the necessity of considering BLNK mutations in children with B cell deficiency, even though they are known to be rare causes of agammaglobulinemia. Our case is also remarkable with high IgM levels before intravenous immunoglobulin replacement therapy and with late-onset severe infections.
Takayasu arteritis initially mimicking infective endocarditis
Authors: Aytekin Alcelik, Sevim Karacay, Ismail Necati Hakyemez, Busra Akin, Serkan Ozturk, Haluk Savli
Journal: Mediterr J Hematol Infect Dis (2011)
MeSH terms: Case Reports

Takayasu's arteritis (TA) is a chronic inflammatory disease that affects large vessels, predominantly the aorta and its main branches, leading to vessel wall thickening, fibrosis and stenosis. Cardiac and vascular symptoms are also commonly present at disease onset. In TA with thoracic or abdominal involvement, although murmur can be present at physical examination, the pulse difference may be absent. Here, we report a case of TA who initially resembled infective endocarditis and had widespread thoracic murmur.
Autochthonous cases of mycetoma in Europe: report of two cases and review of literature
Authors: Dora Buonfrate, Federico Gobbi, Andrea Angheben, Stefania Marocco, Claudio Farina, Jef Van Den Ende, Zeno Bisoffi
Journal: PLoS One (2014)
MeSH terms: Mycetoma / diagnosis, Mycetoma / drug therapy, Mycetoma / epidemiology, Mycetoma / microbiology, Case Reports, Review, Adult, Europe / epidemiology, Humans, Male, Middle Aged

Background:
Mycetoma is a chronic granulomatous infection involving cutaneous and subcutaneous tissues. It is endemic in tropical and subtropical areas, but sporadic cases have been reported also in countries of temperate climate. The purpose of this paper is to review the cases of mycetoma in European subjects (and presumably acquired in Europe), to give an insight in the main factors associated with this condition, and to describe two previously unpublished cases observed at our Centre.
Methods and findings:
PubMed was systematically searched for case reports and case series of mycetoma in Europeans reported between 1980 and 2014, using specific search strategies. Two further cases diagnosed by the authors are described. Forty-two cases were collected. Eleven cases were caused by Scedosporium apiospermium, mainly in immunosuppressed patients from Bulgaria, Germany, the Netherlands, Portugal, Slovenia, Spain and the United Kingdom. Excluding all patients with immunosuppression, 29 cases remain. Most of them were reported from Bulgaria and in Albanian patients (all diagnosed outside Albania). In the Bulgarian case series many different micro-organisms, both bacteria and fungi, were isolated, while all the 5 cases from Albania were caused by Actinomadura spp. Other countries reporting cases were Greece, Italy and Turkey. In general, Actinomadura spp is the most frequent causative agent isolated, followed by Nocardia spp and Madurella mycetomatis. The foot was the most reported site involved. Most patients were medically treated, but unfortunately a long-term follow up (at least one year) was available only in a few cases.
Conclusions:
Our review and our own cases suggest that Europeans without travel history can be affected by Madura foot. The lack of a surveillance system is likely to cause an underreporting of cases. Moreover, the unfamiliarity of Western doctors with this peculiar infection may cause a mismanagement, including unnecessary amputations.
Dry Gangrene in Children with Typhoid Intestinal Perforation: A Report of Two Cases
Authors: Lofty-John C Anyanwu, Aminu M Mohammad, Lawal B Abdullahi, Mustapha U Ibrahim, Aliyu U Farinyaro, Mohammed S Aliyu, Stephen K Obaro
Journal: Case Rep Surg (2018)
MeSH terms: Case Reports

Intestinal perforation is a life-threatening complication of typhoid fever commonly seen in developing countries, but extraintestinal complications are infrequently reported. We report herein two cases of gangrene seen in children managed for typhoid intestinal perforation, highlighting the challenges faced in their management.
Triple Negative Breast Cancer in Pregnancy and Postpartum: Two Case Reports in Hispanic Women
Authors: Ruchi Upadhyay, Qurat-Ul-Ain Butt, Abraham Hamaoui, Cassandra Henderson, Sydney McCalla, Hamid Gilak
Journal: Case Rep Obstet Gynecol (2015)

Objective. Despite studies suggesting that triple negative breast cancer is more often seen in women of African ancestry, we report here two cases of pregnancy associated triple negative breast cancer in Hispanic women. Cases. Case one is a 37-year-old female para 2-0-0-2, who presented with a left breast mass, at 19 weeks of gestation, the biopsy of which reported an invasive ductal carcinoma, found to be triple receptor negative. The patient underwent chemotherapy during the pregnancy and was delivered with a cesarean at 37 weeks for obstetric indication. After delivery, the patient completed her chemotherapy that was followed by radical mastectomy and radiotherapy. Case two is a 28-year-old female para 6-0-1-5, who presented while breast-feeding with signs and symptoms of mastitis, and an engorged and tender right breast, five months postpartum. However, the sonogram revealed a fluid filled cavity. Aspiration and cytology did not reflect an infection and were negative for malignancy. High suspicion and lack of improvement led to biopsy that identified an invasive ductal carcinoma, found to be triple negative. The patient underwent chemotherapy followed by modified radical mastectomy. Conclusions. Triple negative breast cancer, during pregnancy or postpartum, poses a unique challenge and requires a multidisciplinary team to optimize treatment for these women.
Acute pseudogout of the foot following Parathyroidectomy: a case report
Authors: Sari Priesand, Jennifer Wyckoff, James Wrobel, Brian Schmidt
Journal: Clin Diabetes Endocrinol (2017)
Keywords: calcium pyrophosphate dehydrate, diabetes mellitus, parathyroidectomy, pseudogout
MeSH terms: Case Reports

Background:
The current case report is the first in the literature to report the association between parathyroidectomy and an episode of probable pseudogout in the foot in a patient with diabetes mellitus.
Case presentation:
The authors present a case of pseudogout of the left foot following a subtotal parathyroidectomy in an 80-year-old female with type 2 diabetes mellitus and primary hyperparathyroidism. Pseudogout, also known as calcium pyrophosphate dehydrate deposition disease, is an unusual metabolic sequela following parathyroidectomy. Pseudogout attacks have been noted in the immediate post-operative period following parathyroidectomy, but has rarely been identified in the foot. The diagnosis was challenging and there were multiple differential diagnoses that were entertained in this case.
Conclusions:
This case illustrates the importance of reviewing the surgical history as there might be a link between the previous surgeries and current foot problems. This case also serves as a reminder of the importance of calcium and phosphate metabolism in podiatric health. Most specifically it demonstrates again the association of pseudogout and parathyroidectomy in a patient with diabetes mellitus. Although a rare occurrence, it is an important reminder that metabolic imbalances of calcium levels can manifest in any bone.
Case report: Safety and efficacy of voxelotor in a patient with sickle cell disease and stage IV chronic kidney disease
Authors: Awni Alshurafa, Mohamed A Yassin
Journal: Front Med (Lausanne) (2022)
Keywords: chronic kidney disease, hemolysis, sickle cell disease, vaso-occlusive crisis (voc), voxelotor
MeSH terms: Case Reports

Sickle cell disease (SCD) is a heterogeneous group of inherited disorders characterized by the production of sickle hemoglobin which is less soluble than an adult or fetal hemoglobin. Voxelotor is a hemoglobin S polymerization inhibitor that has been approved for sickle cell disease treatment in the adult and adolescent populations. It acts as a hemoglobin modulator by increasing its affinity to oxygen which prevents red blood cells from sickling. Chronic kidney disease is a common but under-reported complication of SCD and it is a leading cause of morbidity and mortality. The data about the safety and efficacy of voxelotor use in chronic kidney disease is limited. Herein we report a 49-year-old man, with sickle cell disease and stage IV chronic kidney disease, who was managed successfully with voxelotor and resulted in decreasing transfusion requirement and vaso-occlusive painful crisis without affecting kidney function.
Neonatal cyanosis: diagnostic and management challenges
Authors: A Izraelit, V Ten, G Krishnamurthy, V Ratner
Journal: ISRN Pediatr (2011)
MeSH terms: Case Reports

Neonatal central cyanosis is always a sign of serious pathological processes and may involve diverse organs and impose a significant diagnostic and therapeutic challenge. Here, we report an unusual presentation of Ebstein's anomaly, a rare congenital heart malformation, as the cause of central cyanosis in a one-week-old full-term infant. Initiation of PEG(1) therapy in neonates with Ebstein's anomaly always needs a very careful consideration because of a high risk for the development of a "circular shunt" leading to severe deterioration of multiple organs perfusion.