OpenMed/multicare-articles huggingface dataset:
Iatrogenic esophageal perforation that could be treated indirectly by cervical esophagostomy and laparoscopic surgery
Authors: Ryohei Matsui, Satoru Takayama, Taku Hattori, Toru Imagami, Masaki Sakamoto, Hisanori Kani
Journal: Int J Surg Case Rep (2019)
Keywords: case report, esophageal perforation, esophagostomy, laparoscopic surgery, two-stage surgery

Introduction:
Successful nonoperative management has been reported for esophageal perforation; however, some cases require surgery.
Case presentation:
We presented the case of an 85-year-old woman with iatrogenic thoracic esophageal perforation in whom primary repair or resection of the perforated esophagus was difficult because she was elderly and had severe aortic valve stenosis. Therefore, we selected a two-stage surgery; laparoscopic gastrostomy, jejunostomy, posterior mediastinal drainage, and cervical esophagostomy were performed. We planned reconstruction after the perforation was closed, but endoscopic examination revealed spontaneous patency of each esophageal stump. Endoscopic balloon dilation was necessary because of esophageal stenosis; however, anastomotic surgery was unnecessary.
Conclusion:
This case report suggests that esophageal perforation is resolved without direct closure if appropriate drainage is performed.
Endometrial cancer in a renal transplant recipient: A case report
Authors: Na Liu, Lei Yang, Yan Long, Guoqing Jiang
Journal: Open Med (Wars) (2020)
Keywords: case report, chemotherapy, endometrial carcinoma, renal transplantation
MeSH terms: Case Reports

As the most effective treatment for end-stage renal diseases, renal transplantation can improve the quality of life of patients and prolong the survival time. However, during the prolonged survival time, malignancy has become one of the main causes of death of recipients, which vary geographically. Tumors in the digestive system and urothelial tumors have been highly reported in Asia. In general, the gynecological malignant tumors have been rarely reported, especially the endometrial carcinoma. Herein, a 63-year-old female renal transplant recipient diagnosed with endometrial carcinoma (15 years after transplantation) was reported. The patient had suffered irregular postmenopausal bleeding for a short time before hospitalization. She underwent abdominal hysterectomy, bilateral salpingo-oophorectomy, right pelvic lymphadenectomy, right para-aortic lymphadenectomy and omental excision. Postoperative pathology showed ovarian and pelvic lymph node metastasis and pathological stage IIIC. After six courses of chemotherapy with paclitaxel 270 mg + carboplatin 500 mg, the patient's renal function was normal. During the third cycle of chemotherapy, the patient suffered a third-degree bone marrow suppression and returned to normal soon when treated with the recombinant human granulocyte stimulating factor. In conclusion, early screening of gynecologic tumors is important for female patients after renal transplantation, which has a positive significance for the prognosis improvement.
Endourologic and Open Ureterolithotomy and Common Sheath Reimplant for Large Bladder and Distal Ureteral Calculi
Authors: Madeline Cancian, Joseph Brito, Joseph Renzulli 2nd, Gyan Pareek
Journal: J Endourol Case Rep (2016)
Keywords: duplicate ureter, lithotripsy, ureteroscopy, urolithiasis
MeSH terms: Case Reports

A twenty-eight-year-old female with a history of suprapubic pain and recurrent urinary tract infections presents for urology referral with a kidney, ureter, and bladder radiograph showing a 4.4 cm bladder calculus and 6.5 cm distal left ureteral stone. She underwent effective cystolitholapaxy of the bladder stone. Endourologic attempt (left ureteroscopy) was unsuccessful because of ureteral stone burden. Findings at ureteroscopy revealed a duplicated system on the left with the lower pole moiety joining just proximal to the ureteral orifice. The stone was found to be in the upper pole moiety ureter. An open ureterolithotomy was performed with intraoperative ureteroscopic laser lithotripsy and common sheath ureteral reimplant. Furthermore, a previously placed stent was found to be encrusted at the time of the ureterolithotomy. Effective ureteroscopy and lasering were performed through the ureterotomy up to the renal pelvis of the upper pole ureter.
SARS-CoV-2 Infection-Associated Aortic Thrombosis Treated with Oral Factor Xa Inhibition
Authors: Alena Strýčková, Jakub Benko, Martin Jozef Péč, Monika Péčová, Jana Žolková, Monika Brunclíková, Tomáš Bolek, Ján Staško, Matej Samoš, Marián Mokáň
Journal: Case Rep Hematol (2022)
MeSH terms: Case Reports

Coronavirus disease 2019 (COVID-19) is an acute complex systemic disorder caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).While SARS-CoV-2 is known to cause significant pulmonary disease, various extrapulmonary manifestations of COVID-19 have also been reported. Growing evidence suggests that COVID-19 is associated with coagulopathy leading to micro and macrovascular complications. Although in patients with COVID-19, venous thromboembolic events are more frequent, arterial thrombosis also occurs at an increased rate. These often lead to acute life-threatening ischemia, which requires urgent diagnosis and treatment. We present case reports of two patients with an abnormal thrombus formation in the thoracic aorta who recently overcame COVID-19, which led to systemic embolism and splenic infarction. Ambulatory oral factor Xa inhibitor therapy led to aortic thrombosis resolution in both patients.
Cor Triatriatum Dexter: An Innocent Bystander
Authors: Stephanie C Fuentes Rojas, Gerald Lawrie, Nadeen N Faza
Journal: Methodist Debakey Cardiovasc J (2022)
Keywords: cor triatriatum dexter, multimodality imaging
MeSH terms: Cor Triatriatum / diagnostic imaging, Cor Triatriatum / surgery, Heart Defects, Congenital, Tricuspid Valve Insufficiency, Case Reports, Aged, Female, Humans, Multimodal Imaging

Cor triatriatum dexter is a rare congenital heart defect with a varied clinical presentation ranging from asymptomatic to right heart failure. Accurate diagnosis is imperative as it may affect clinical decision making. We present a multimodality imaging assessment of cor triatriatum dexter in a 70-year-old woman with severe tricuspid regurgitation.
Case report: Pleural effusion during tyrosine-kinase inhibitor treatment in chronic myeloid leukemia: Not only a dasatinib-related adverse event
Authors: Raffaella Pasquale, Cristina Bucelli, Valentina Bellani, Manuela Zappa, Alessandra Iurlo, Daniele Cattaneo
Journal: Front Oncol (2022)
Keywords: adverse event, chronic myeloid leukemia, nilotinib, pleural effusion, tyrosine-kinase inhibitor
MeSH terms: Case Reports

The spectrum of TKI-related adverse events (AEs) is variable. Pleural effusion (PE) is a frequent AE attributable to dasatinib treatment, while it is only rarely associated with nilotinib. The pathogenetic mechanism leading to PE during nilotinib therapy is still unknown and its management has not yet been defined. To the best of our knowledge, only a limited number of similar case reports have already been reported in the literature so far. Here, we describe the case of a 41-year-old CML patient who developed PE during first-line nilotinib, successfully treated with steroids and nilotinib permanent discontinuation. We highlight the differences among our patient and the others, proposing therapeutic strategies to solve this rare but still possible AE, of which physicians should be aware.
Impact of Methamphetamine Abuse: A Rare Case of Rapid Cerebral Aneurysm Growth with Review of Literature
Authors: James Fowler, Brian Fiani, Syed A Quadri, Vladimir Cortez, Mudassir Frooqui, Atif Zafar, Fahad Shabbir Ahmed, Asad Ikram, Anirudh Ramachandran, Javed Siddiqi
Journal: Case Rep Neurol Med (2018)
MeSH terms: Case Reports

Methamphetamine or "meth" is a sympathomimetic amine of the amphetamine-type substances (ATS) class with an extremely high potential for abuse. Illicitly abused neurostimulants like cocaine and meth predispose patients to the aneurysmal formation with reported rupture at a younger age and in much smaller sized aneurysms. However, very rapid growth of aneurysm within less than 2 weeks with methamphetamine abuse is very rarely observed or reported. In this report, we present a patient with repeated and recurrent meth abuse who demonstrated rapid growth of a pericallosal aneurysm over the period of less than two weeks. The pathophysiology of stroke related to meth and ATS abuse is multifactorial with hypertension, tachycardia, and vascular disease postulated as major mechanisms. The rapid growth of an aneurysm has a high risk of aneurysmal rupture and SAH, which is a neurosurgical emergency and therefore warrants careful consideration and close monitoring. This case confirms the dynamic temporal effects of methamphetamine use on intracranial vessels and this specific neurostimulants association to rapid aneurysmal formation. In light of vascular pathologies the possibility of drug-induced pseudoaneurysm should also be considered in young patients with history of meth abuse.
Transient symptomatic hyperglycaemia secondary to inhaled fluticasone propionate in a young child
Authors: Mara Lelii, Nicola Principi, Susanna Esposito
Journal: BMC Pulm Med (2016)
MeSH terms: Adrenal Cortex Hormones / adverse effects, Anti-Inflammatory Agents / adverse effects, Asthma / drug therapy, Fluticasone / adverse effects, Hyperglycemia / chemically induced, Case Reports, Administration, Inhalation, Child, Preschool, Humans, Male, Recurrence, Respiratory Sounds, Adrenal Cortex Hormones, Anti-Inflammatory Agents, Fluticasone

Background:
Inhaled corticosteroids (ICSs) are currently used to prevent and treat asthma and recurrent wheezing attacks in children. Fluticasone propionate (FP) is one of the most commonly prescribed ICSs because it is considered effective and well tolerated.
Case presentation:
A male infant of approximately 1 year of age, who was born to parents without relevant clinical problems or family histories including diabetes, was brought to our attention for recurrent wheezing. When he was approximately 2 years old, a regular daily inhaled treatment with FP given using a spacer was prescribed. With this therapy, the child obtained good control of his symptoms with no further recurrences, but after approximately 2 months of treatment he was admitted to the emergency room because he was whining and agitated and exhibited increased diuresis and water intake. Laboratory tests revealed hyperglycaemia (181 mg/dL), mild glycosuria, blood alkalosis (pH 7.49), a bicarbonate level of 31 mmol/L, a pCO2 level of 39 mmHg, a serum sodium level of 135 mEq/L and a serum potassium level of 3.5 mEq/L. The parents confirmed that the recommended dose of FP had been administered with no increase in the amount of drug. The child was immediately treated with endovenous infusion of physiological saline for 24 h, and his glycaemic levels as well as venous blood gas analysis returned to normal, with an absence of glucose in the urine. Oral glucose tolerance test results and glycated haemoglobin levels were normal. Monitoring of blood glucose levels before and after meals for three consecutive days did not reveal any further increase above normal levels. He was discharged with a diagnosis of transient symptomatic hyperglycaemia during ICS therapy and the suggestion to replace his inhaled FP therapy with oral montelukast. Montelukast was continued for 6 months; during this time, the child did not present any other hyperglycaemia episodes.
Conclusions:
Although there is no evidence of causation, this case report represents an interesting and unusual description of paediatric transient symptomatic hyperglycaemia after treatment with inhaled FP and highlights the importance of considering this potential adverse event and the necessity of informing parents of the possible clinically relevant risks associated with this drug.
An Intervention Framework to Facilitate Psychological Trauma Management in High-Risk Occupations
Authors: Bouwer E Jonker, Lene Ilyna Graupner, Lizelle Rossouw
Journal: Front Psychol (2020)
Keywords: high-risk occupations, intervention framework, psychological trauma, trauma management framework, trauma management programs, workplace trauma

Various psychological trauma management programs (PTMPs) are offered to assist employees who have been exposed to a traumatic event in the workplace. There is, however, limited literature available on how employees in high-risk occupations experience these programs. This study qualitatively explored the experiences of PTMPs from the perspective of employees working in three high-risk occupations. The purpose of this study was to explore the experiences of the participants in order to compile a framework that could help support and improve the productivity and wellbeing of employees affected by work-related trauma. The study used a qualitative research design based on an approach informed by interpretivism and social constructivism. A multiple-case study was used as research strategy to incorporate three sectors in South Africa, namely mining, policing, and emergency medical services. Data were gathered through semi-structured interviews and focus groups, and analyzed using thematic analysis. The findings across the three sectors showed effective strategies considered by participants to manage psychological trauma. These strategies include multiple counseling sessions, face-to-face counseling, regaining control, and receiving support. Strategies that were viewed as ineffective include inability of counselors to relate to the participants' work environments, lack of involvement, lack of supervisor support, unavailability of counseling and specialized skills, premature resuming of duties, and a single-dimension approach. Based on the findings, an intervention framework is proposed to address psychological trauma in high-risk occupations.
Diagnosis and treatment of multiseptate gallbladder with recurrent abdominal pain
Authors: Turgut Karaca, Omer Yoldas, Bulent Caglar Bilgin, Selma Bilgin, Ender Evcik, Saadet Ozen
Journal: Case Rep Med (2011)
MeSH terms: Case Reports

Laparoscopic cholecystectomy is usually performed for gallstones or polyp of the gallbladder. Multiseptate gallbladder is a rare congenital malformation. Although several asymptomatic cases have been described, patient usually present with right upper abdominal pain. We present a 29-year-old female patient with multiseptate gallbladder, cholecystectomy was performed, and her abdominal pain and gastrointestinal complaints have resolved.
Motor-Sparing Neural Ablation with Modified Techniques for Knee Pain: Case Series on Knee Osteoarthritis and Updated Review of the Underlying Anatomy and Available Techniques
Authors: Tony Kwun-Tung Ng, King Hei Stanley Lam, Abdallah El-Sayed Allam
Journal: Biomed Res Int (2022)
MeSH terms: Osteoarthritis, Knee / surgery, Review, Humans, Knee Joint / surgery, Pain, Pain Management / methods, Pain Measurement

Knee osteoarthritis (KOA) is ubiquitous. However, effective pain managements for patients with grades 3 or 4 KOA for whom conservative treatments are unsuccessful, but for whom surgery is not an option, remain lacking. This case series presented two motor-sparing interventional pain treatment modalities for five such patients. Three of the patients with a mean total WOMAC score of 41 underwent thermal radiofrequency (RF) ablation using a modified motor-sparing approach. One-week and four-week post-RF, the total score dropped to 27 (by 34%) and 19 (dropped 53.7%), respectively. Two other similar patients with a mean total WOMAC score 96 underwent chemical neurolysis using a motor-sparing approach with modified landmarks. The WOMAC score dropped to 58.5 (by 39.1%) and 49 (dropped by 49.0%), one-week and four-week postchemical neurolysis, respectively. A narrative review of the currently available approaches is also provided, with the conclusion that neural ablation using the modified landmarks approach may achieve better pain control and preserve the motor functions for patients with severe KOA for whom conservative treatment was unsuccessful and who are not candidates for surgery.
CT and MRI Findings of Autoimmune Polymorph Bifocal Pancreatitis Mimicking Pancreatic Adenocarcinoma: A Case Report and Review of the Literature
Authors: Roman Rotzinger, Hendrik Bläker, Marcus Bahra, Timm Denecke, Christian Grieser
Journal: J Investig Med High Impact Case Rep (2015)
Keywords: aip, ct, mri, autoimmune pancreatitis, bifocal, mimicking, pancreatic adenocarcinoma, pancreatic cancer

Autoimmune pancreatitis is a rare type of chronic pancreatitis. It is supposed to be a pancreatic manifestation of an immune-complex modulated systemic disorder. In contrast, pancreatic adenocarcinoma is the most frequent malignant neoplasm of the pancreas. Within the rare type of focal autoimmune pancreatitis, only few presentations with multifocal pancreatic lesions have been described. Herein we report a case of a 58-year-old patient with autoimmune pancreatitis presenting with bifocal manifestations of the pancreatic head and tail, mimicking pancreatic adenocarcinoma clinically, on computed tomography and magnetic resonance imaging. Typical imaging findings of autoimmune pancreatitis are compared with typical findings in pancreatic carcinoma. The diagnostic dilemma of differentiating between both entities is discussed. A review of the present literature regarding multifocal presence of autoimmune pancreatitis is performed.
Tessier no. 3 incomplete cleft reconstruction with alar transposition and irregular z-plasty
Authors: Orhan Cizmeci, Samet Vasfi Kuvat
Journal: Plast Surg Int (2011)
MeSH terms: Case Reports

Facial clefts are extremely rare congenital deformities and there are only a few technique reports for surgical reconstruction of clefts in the literature. In this article, we report a Tessier no. 3 incomplete cleft reconstruction with alar transposition and irregular Z-plasty in a 2-year old female patient.
Slowly developing toxic epidermal necrolysis-like reaction associated with pemetrexed and carboplatin
Authors: Gerhard Eichhoff
Journal: Ecancermedicalscience (2020)
Keywords: cutaneous adverse drug reactions, drug rash, pemetrexed, toxic epidermal necrolysis
MeSH terms: Case Reports

Most cutaneous adverse drug reactions reported in association with chemotherapy, such as a limited maculopapular rash, are considered mild and do not affect the continuation of the treatment. Toxic epidermal necrolysis (TEN), however, is a life-threatening reaction that needs treatment discontinuation. The present case shows the slow progression from a pemetrexed and carboplatin-associated maculopapular rash to a TEN-like reaction.
Factor Score Regression With Social Relations Model Components: A Case Study Exploring Antecedents and Consequences of Perceived Support in Families
Authors: Justine Loncke, Veroni I Eichelsheim, Susan J T Branje, Ann Buysse, Wim H J Meeus, Tom Loeys
Journal: Front Psychol (2018)
Keywords: factor score regression, family social relations model, missing data, perceived support, structural equation modeling

The family social relations model (SRM) is applied to identify the sources of variance in interpersonal dispositions in families, but the antecedents or consequences of those sources are rarely investigated. Simultaneous modeling of the SRM with antecedents or consequences using structural equation modeling (SEM) allows to do so, but may become computationally prohibitive in small samples. We therefore consider two factor score regression (FSR) methods: regression and Bartlett FSR. Based on full information maximum likelihood (FIML), we derive closed-form expressions for the regression and Bartlett factor scores in the presence of missingness. A simulation study in both a complete- and incomplete-case setting compares the performance of these FSR methods with SEM and an ANOVA-based approach. In both settings, the regression FIML factor scores as explanatory variable produces unbiased estimators with precision comparable to the SEM-estimators. When SRM-effects are used as dependent variables, none of the FSR methods are a suitable alternative for SEM. The latter result deviates from previous studies on FSR in more simple settings. As an example, we explore whether gender and past victimhood of relational and physical aggression are antecedents for family dynamics of perceived support, and whether those dynamics predict physical and relational aggression.
Metapath Aggregated Graph Neural Network and Tripartite Heterogeneous Networks for Microbe-Disease Prediction
Authors: Yali Chen, Xiujuan Lei
Journal: Front Microbiol (2022)
Keywords: covid-19, heterogeneous network, metapath aggregated graph neural network, microbe-disease associations, multi-head attention mechanism

More and more studies have shown that understanding microbe-disease associations cannot only reveal the pathogenesis of diseases, but also promote the diagnosis and prognosis of diseases. Because traditional medical experiments are time-consuming and expensive, many computational methods have been proposed in recent years to identify potential microbe-disease associations. In this study, we propose a method based on heterogeneous network and metapath aggregated graph neural network (MAGNN) to predict microbe-disease associations, called MATHNMDA. First, we introduce microbe-drug interactions, drug-disease associations, and microbe-disease associations to construct a microbe-drug-disease heterogeneous network. Then we take the heterogeneous network as input to MAGNN. Second, for each layer of MAGNN, we carry out intra-metapath aggregation with a multi-head attention mechanism to learn the structural and semantic information embedded in the target node context, the metapath-based neighbor nodes, and the context between them, by encoding the metapath instances under the metapath definition mode. We then use inter-metapath aggregation with an attention mechanism to combine the semantic information of all different metapaths. Third, we can get the final embedding of microbe nodes and disease nodes based on the output of the last layer in the MAGNN. Finally, we predict potential microbe-disease associations by reconstructing the microbe-disease association matrix. In addition, we evaluated the performance of MATHNMDA by comparing it with that of its variants, some state-of-the-art methods, and different datasets. The results suggest that MATHNMDA is an effective prediction method. The case studies on asthma, inflammatory bowel disease (IBD), and coronavirus disease 2019 (COVID-19) further validate the effectiveness of MATHNMDA.
Primary uterine cervix schwannoma: a case report and review of the literature
Authors: Maryam Tahmasbi, Johnny Nguyen, Masoumeh Ghayouri, Yuan Shan, Ardeshir Hakam
Journal: Case Rep Pathol (2012)

Schwannoma (neurilemmoma) is a benign peripheral nerve sheath tumor that occurs in a wide variety of locations; however, its finding in the uterine cervix is extremely rare. We report a case of an incidental primary benign cervical schwannoma in a 48-year-old woman. In the English literature, a few cases of primary schwannoma of the cervix have been reported, which include seven cases of primary malignant cervical schwannoma and only two that are benign. These cases are reviewed in the following discussion.