OpenMed/multicare-articles huggingface dataset:
MIDA: A Multimodal Imaging-Based Detailed Anatomical Model of the Human Head and Neck
Authors: Maria Ida Iacono, Esra Neufeld, Esther Akinnagbe, Kelsey Bower, Johanna Wolf, Ioannis Vogiatzis Oikonomidis, Deepika Sharma, Bryn Lloyd, Bertram J Wilm, Michael Wyss, Klaas P Pruessmann, Andras Jakab, Nikos Makris, Ethan D Cohen, Niels Kuster, Wolfgang Kainz, Leonardo M Angelone
Journal: PLoS One (2015)
MeSH terms: Head / anatomy & histology, Image Processing, Computer-Assisted / methods, Models, Anatomic, Neck / anatomy & histology, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S., Anisotropy, Brain Mapping, Computer Simulation, Diffusion Tensor Imaging, Head / blood supply, Humans, Magnetic Resonance Angiography, Magnetic Resonance Imaging, Mesencephalon / anatomy & histology, Mesencephalon / blood supply, Midline Thalamic Nuclei / anatomy & histology, Midline Thalamic Nuclei / blood supply, Multimodal Imaging, Neck / blood supply, Neck / innervation

Computational modeling and simulations are increasingly being used to complement experimental testing for analysis of safety and efficacy of medical devices. Multiple voxel- and surface-based whole- and partial-body models have been proposed in the literature, typically with spatial resolution in the range of 1-2 mm and with 10-50 different tissue types resolved. We have developed a multimodal imaging-based detailed anatomical model of the human head and neck, named "MIDA". The model was obtained by integrating three different magnetic resonance imaging (MRI) modalities, the parameters of which were tailored to enhance the signals of specific tissues: i) structural T1- and T2-weighted MRIs; a specific heavily T2-weighted MRI slab with high nerve contrast optimized to enhance the structures of the ear and eye; ii) magnetic resonance angiography (MRA) data to image the vasculature, and iii) diffusion tensor imaging (DTI) to obtain information on anisotropy and fiber orientation. The unique multimodal high-resolution approach allowed resolving 153 structures, including several distinct muscles, bones and skull layers, arteries and veins, nerves, as well as salivary glands. The model offers also a detailed characterization of eyes, ears, and deep brain structures. A special automatic atlas-based segmentation procedure was adopted to include a detailed map of the nuclei of the thalamus and midbrain into the head model. The suitability of the model to simulations involving different numerical methods, discretization approaches, as well as DTI-based tensorial electrical conductivity, was examined in a case-study, in which the electric field was generated by transcranial alternating current stimulation. The voxel- and the surface-based versions of the models are freely available to the scientific community.