OpenMed/multicare-articles huggingface dataset:
Positron emission tomography-computer tomography scan used as a monitoring tool following cellular therapy in cerebral palsy and mental retardation-a case report
Authors: Alok Sharma, Hemangi Sane, Amruta Paranjape, Nandini Gokulchandran, Pooja Kulkarni, Anjana Nagrajan, Prerna Badhe
Journal: Case Rep Neurol Med (2013)

Cerebral palsy (CP) is one of the non-progressive neurological diseases caused by damage to the brain tissue at birth, which leads to physical, cognitive and perceptive symptoms. Even after lifelong medical and therapeutic management there are residual deficits which affect the quality of life of the patients and their families. We examined a maximally rehabilitated, 20 year old male suffering from CP and Mental Retardation (MR). He had diplegic gait and Intelligence Quotient (IQ) score of 44 with affected fine motor activities, balance, speech and higher functions. Positron Emission Tomography-Computer Tomography (PET-CT) scan identified frontal, temporal, parietal, occipital, left cerebellar lobes, amygdala, hippocampus, and parahippocampus as the affected areas. He was treated with cellular therapy of Autologous Bone Marrow Derived Mono-Nuclear Cells (MNCs) transplantation followed by multidisciplinary rehabilitation. Six months following therapy, PET-CT scan showed significant increase in metabolic activity in all four lobes, mesial temporal structures and left cerebellar hemisphere, also supported by clinical improvement in IQ, social behavior, speech, balance and daily functioning. These findings provide preliminary evidence to support the efficacy of cellular therapy for the treatment of CP with MR. PET-CT scan can also be viewed as an impressive tool to monitor the effects of cellular therapy.
Intrahepatic cholestasis in sickle cell disease: a case report
Authors: Denise Menezes Brunetta, Ana Cristina Silva-Pinto, Maria do Carmo Favarin de Macedo, Sarah Cristina Bassi, Joao Victor Piccolo Feliciano, Fernanda Borges Ribeiro, Benedito de Pina Almeida Prado Jr, Gil Cunha De Santis, Ivan de Lucena Angulo, Dimas Tadeu Covas
Journal: Anemia (2011)
MeSH terms: Case Reports

Intrahepatic cholestasis (SCIC) is an uncommon but potentially fatal complication of sickle cell disease (SCD), with a high death rate, observed mainly in patients with homozygous sickle cell anemia. Herein, we describe a case of severe SCIC treated successfully with aggressive manual exchange transfusion (ET). The patient was admitted with enlarged liver and signs of hepatic failure, such as hyperbilirubinemia and coagulopathy. There was no evidence of viral hepatitis or biliary obstruction. We performed several sessions of ET in order to reduce the percentage of HbS to levels inferior to 30%, which was successfully accomplished. The patient had a complete recovery of hepatic function. This case has shown that ET is an effective treatment of SCIC and should be introduced early on the onset of this severe complication.
Cutaneous Myoepithelioma: An Unusual Tumor in the Hand
Authors: Nelson Montalvo, Ligia Redrobán, David Galarza, Iván Ramírez
Journal: Case Rep Pathol (2020)
MeSH terms: Case Reports

Cutaneous myoepithelioma (CM) is a rare tumor among the primary skin neoplasms. We present the case of a patient with a diagnosis of CM in the right hypothenar region. Histological study showed a proliferation of myoepithelial cells with a solid, reticular growth pattern in a chondromyxoid stroma. The tumor cells were positive for CK AE, S-100, EMA, and p63.
Hyperhomocysteinemia in men with a reproductive history of fetal neural tube defects: Three case reports and literature review
Authors: Yang Yu, Chunshu Jia, Qingyang Shi, Yueying Zhu, Yanhong Liu
Journal: Medicine (Baltimore) (2019)
MeSH terms: Hyperhomocysteinemia / genetics, Methylenetetrahydrofolate Reductase (NADPH2) / genetics, Neural Tube Defects / genetics, Case Reports, Adult, Humans, Male, Mutation, MTHFR protein, human, Methylenetetrahydrofolate Reductase (NADPH2)

Rationale:
Hereditary hyperhomocysteinemia results from a polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene that reduces folate metabolism. Mutations in the MTHFR gene are common in parents who have given birth to children with neural tube defects (NTDs). Most research has focused on the risk for fetal NTDs in women with hyperhomocysteinemia and MTHFR gene mutations. Studies investigating the association between hyperhomocysteinemia, MTHFR gene mutations, and the risk for fetal NTDs in men are scarce.
Patient concerns:
Here, we report on 3 men with hyperhomocysteinemia and the MTHFR C677T homozygous TT genotype that have reproductive histories of fetal NTDs.
Diagnosis:
these 3 men were diagnosed as hyperhomocysteinemia and MTHFR C677T homozygous TT genotype.
Interventions:
Three men received homocysteine-lowering therapy.
Outcomes:
The first man's wife became pregnant, and a healthy infant was spontaneously delivered at term, the other 2 men's wives are still not pregnant.
Lessons:
Findings from this case reports and published literature imply that hereditary hyperhomocysteinemia in men affects sperm quality and sperm DNA methylation and causes epigenetic modifications that can result in fetal NTDs. We recommend monitoring homocysteine and folate levels in men before conception and supplementing with folate as needed, especially in men with a reproductive history of fetuses with neural tube or other birth defects.
beta-Thalassaemia Major in a Spanish Patient due to a Compound Heterozygosity for CD39 C --> T/-28 A --> C
Authors: Soledad Gamarra, Guillermo Garcia-Effron, Carmen Monteserin, Isabel Lopez-Villar, Florinda Gilsanz, Joaquín Martinez-Lopez
Journal: Adv Hematol (2009)
MeSH terms: Case Reports

A Spanish male patient with beta-thalassaemia major was studied. Compound heterozygosity was found for one of the most common beta-globin gene mutations in the Spanish population (codon 39 C --> T) and for a mutation in the TATA box element of the beta-globin gene promoter (-28 A --> C mutation). To our knowledge this is the first report of a CD39 C --> T and -28 A --> C change association and the first report of the -28 A --> C substitution in a Spanish patient.
Simultaneous Presentation of Uveitic Disc Edema and Papilledema in an Adult
Authors: Chase A Liaboe, Michael S Lee, Justin J Y Yamanuha
Journal: Case Rep Ophthalmol Med (2020)
MeSH terms: Case Reports

Purpose:
To present a case of simultaneous uveitic disc edema and increased intracranial pressure (IICP) in an adult.
Methods:
Retrospective case report. Patients. A 29-year-old woman affected by bilateral optic disc edema from bilateral posterior uveitis complicated by IICP with papilledema.
Results:
Laboratory workup was negative for infectious and systemic inflammatory causes of uveitis. Computed Tomography scan of the chest was negative for Sarcoidosis. Magnetic Resonance Imaging of the brain and orbits revealed a partially empty sella, bilateral posterior globe flattening without optic nerve sheath enhancement, masses, white matter lesions, or meningeal enhancement. Cerebral Magnetic Resonance Venography showed narrowing of the right and left transverse sinuses without thromboses. Prednisone was initiated for the uveitis which improved the vision but caused weight gain. Neurology evaluation with a lumbar puncture in the lateral decubitus position revealed elevated opening pressure and otherwise normal cerebrospinal fluid. Ocular ultrasonography was considered but not available to measure optic nerve sheath diameter. Oral acetazolamide 1000 mg twice daily was started for papilledema as prednisone was tapered. Periocular steroid and intravitreal bevacizumab injections were used for sight threatening cystoid macular edema and choroidal neovascularization, respectively. Discussion. While previously described in children, we report the first known case of bilateral uveitic disc edema and papilledema in an adult. This report will discuss recommendations for evaluation of these rarely concurrent conditions and therapy for both uveitic disc edema and papilledema.
Squamous cell carcinoma on top of urethral stricture: case report and review of the literature
Authors: Ahmed Fouad Kotb, Doaa Attia, Asmaa Mohamed Ismail, Ahmed Elabbady
Journal: Ecancermedicalscience (2013)
Keywords: penile cancer, pseudoepitheliomatous hyperplasia, urethral stricture
MeSH terms: Case Reports

Introduction:
Urethral stricture is a common urological condition, resulting from trauma or venereal infections. The aim of our study was to report a rare case of squamous cell carcinoma of the penis and pseudoepitheliomatous hyperplasia (PEH) of scrotal skin, on top of repeatedly managed urethral stricture which was of unknown aetiology.
Methods:
A Medline search of publications studying the association of urethral stricture with penile cancer was done.
Results:
Two case reports were identified that described two occurrences, which were separated by a few months.
Conclusion:
Repeated management of urethral stricture with visual urethrotomy or urethral dilation may result in a chronic inflammatory status, predisposing to PEH and squamous cell carcinoma of the genital organs.
Targeting-intratumoral-lactic-acidosis transcatheter-arterial-chemoembolization for non-islet cell tumor hypoglycemia secondary to a liver metastatic solitary fibrous tumor: A case report and literature review
Authors: Kai Jin, Shan Zhong, Liya Lin, Jianjun Wu, Yuqi Wang, Weijuan Cui, Wei Gu, Ming Chao, Xiaoxiao Song
Journal: Front Endocrinol (Lausanne) (2022)
Keywords: doege–potter syndrome, tila-tace, hypoglycemia, non-islet cell tumor, solitary fibrous tumor
MeSH terms: Acidosis, Gastrointestinal Neoplasms, Hypoglycemia, Soft Tissue Neoplasms, Solitary Fibrous Tumors, Case Reports, Review, Research Support, Non-U.S. Gov't, Congenital Abnormalities, Humans, Kidney / abnormalities, Kidney Diseases / congenital, Liver, Male, Middle Aged, Urogenital Abnormalities, Hereditary renal agenesis, Renal Adysplasia

Doege-Potter syndrome is a rare paraneoplastic syndrome characterized by non-islet cell tumor hypoglycemia secondary to a solitary fibrous tumor. Doege-Potter syndrome always presents with recurrent fasting hypoglycemia, which can occasionally be life-threatening. The best choice of treatment for Doege-Potter syndrome and solitary fibrous tumor is complete resection. However, when it is unfeasible, local-regional treatment can be used as a palliative therapy. Herein, we report a case of a 46-year-old man with Doege-Potter syndrome that occurred secondary to the liver and pancreatic metastatic solitary fibrous tumors. After he received six rounds of targeting-intratumoral-lactic-acidosis transcatheter-arterial-chemoembolization (TILA-TACE) treatment in our hospital, his hypoglycemia was clinically cured, and the liver metastatic tumor was well controlled. We suggest that TILA-TACE can be considered when curative resection is unfeasible for metastatic liver solitary fibrous tumors to help a patient obtain further surgery opportunities.
Histopathologic Effects of Dirofilaria immitis Microfilaria on Internal Organs of Dog Confirming by PCR Technique
Authors: Ao Ceribasi, S Simsek
Journal: Iran J Parasitol (2012)
Keywords: dirofilaria immitis, dog, histopathology, pcr, paraffin
MeSH terms: Case Reports

Background:
The heartworm disease is an infectious disease of dogs with Dirofilaria immitis combined with cardiovascular and circulatory abnormalities. The heartworm disease can become a serious health risk when associated with a severe infection. In this study, a male, 8 year-old dog that died suddenly was necropsied and all tissues were examined grossly.
Methods:
Major organs including heart, lungs, liver, spleen, kidneys, brain, eyes, and testis were fixed in 10% neutral formalin, embedded in paraffin, sectioned at 5-µm thickness, stained with hematoxylin and eosin, and examined with a light microscope. For each examined organ, paraffin-embedded tissues were cut and placed in eppendorf tubes for genomic DNA extraction. PCR was performed using two sets of primers for amplification of a 302 bp ITS-2 gene fragment and a 203 bp cytochrome oxidase subunit 1 (CO1) gene fragment of D. immitis.
Results:
During the necropsy examination, 46 adult D. immitis were found in the portal vein, right ventricle, and atrium of the heart and pulmonary trunk. Microscopically, microfilarias were found throughout the vessels of different organs including lungs, kidneys, liver, heart, brain, and spleen. All tissues examined by PCR were positive for D. immitis ITS-2 and CO1.
Conclusion:
PCR technique now represents an effective method for identification of D. immitis from formalin-fixed samples.
Unusual Case of Localized Upper Limbs and Truncal Edema Associated with Fever, Anemia, and Acute Kidney Injury
Authors: Mohammad Tinawi
Journal: Case Rep Med (2019)
MeSH terms: Case Reports

The patient is a 75-year-old man who presented with right arm pain, edema, and erythema. The same manifestations appeared in the other arm 3 weeks later. He also developed fever, acute kidney injury, anemia, and truncal edema. Initial extensive evaluation was unrevealing. He was noted to have elevated creatine kinase, and a diagnostic muscle biopsy lead to diagnosis of inflammatory myositis. He improved with corticosteroids.
Post-surgical Thyroid Bed Pyoderma Gangrenosum Mimicking Recurrent Papillary Thyroid Carcinoma
Authors: Alessia Dolci, Rita Indirli, Giovanni Genovese, Federica Derlino, Maura Arosio, Angelo Valerio Marzano
Journal: Front Endocrinol (Lausanne) (2019)
Keywords: differentiated thyroid carcinoma, papillary thyroid carcinoma, pathergy, pyoderma gangrenosum, thyroidectomy
MeSH terms: Case Reports

Background: Pyoderma gangrenosum (PG) is a rare inflammatory disease presenting with chronic-recurrent cutaneous ulcers histopathologically hallmarked by neutrophilic infiltrates, which may occur more frequently at sites of surgical traumas. The disease is habitually limited to the skin, but it can virtually involve any organ. Nevertheless, no prior cases of PG involving the thyroid bed have ever been reported. Case Report: A bilateral PG of the breast was diagnosed in a 51-year-old woman and treated with intravenous methylprednisolone pulse-therapy and cyclosporine, with partial improvement. During the hospitalization, cytological examination of two hypoechoic thyroid nodules by fine-needle aspiration (FNA) was consistent with thyroid carcinoma. After total thyroidectomy, histopathology confirmed a papillary thyroid cancer (PTC), and radioactive iodine ablation was performed. At 12-month ultrasonographic follow-up, two hypoechoic avascular areas localized in the empty thyroid bed raised the suspect of PTC recurrence. However, (i) undetectable levels of thyroglobulin without anti-thyroglobulin antibodies, (ii) neutrophilia and increased inflammatory marker levels, and (iii) cytological examination of FNA showing numerous neutrophils induced to suspect thyroid bed PG infiltration. An ex juvantibus approach with high-dose methylprednisolone led to dimensional reduction of the hypoechoic areas on ultrasonography, thus confirming the hypothesis of thyroid bed PG. Conclusion: This case of thyroid bed PG supports the idea that PG reflects a cutaneous phenotype encompassed in the spectrum of systemic neutrophilic diseases. Endocrinologists should be aware that thyroid bed PG involvement is an albeit rare differential diagnosis to consider in patients who had undergone thyroid surgery, especially with a history of PG.
Xanthogranulomatous osteomyelitis presenting as swelling in right tibia
Authors: Girish Kamat, Vandana Gramapurohit, Aneel Myageri, Chidendra Shettar
Journal: Case Rep Pathol (2011)
MeSH terms: Case Reports

Xanthogranulomatous osteomyelitis is a very rare form of chronic osteomyelitis which presents like a bone tumor. Three cases of xanthogranulomatous osteomyelitis have been described previously in the literature. We present a case of xanthogranulomatous osteomyelitis occurring in the distal part of tibia. This case presented as swelling in a 13-year-old boy. Simple curettage proved to be curative in the present case.
Lumbar Radiculitis as a Complication of Vaccination against Tick-Borne Encephalitis: A Differential Diagnosis of Low Back Pain and Nerve Root Compression
Authors: Craig Kingston, Günther Zech, Caroline Pauli, Ulrich Walker
Journal: Case Rep Med (2020)
MeSH terms: Case Reports

Serious adverse reactions following immunisation with adult tick-borne encephalitis (TBE) vaccines are rare, but when they occur, they most frequently involve the nervous system. We present a case of a female patient who developed a sensory and motor L4 monoradiculopathy following self-injection of an inactivated vaccine against TBE in the ipsilateral quadriceps muscle. The motor and sensory L4 dysfunction vanished after 12 months. TBE vaccine-induced radiculopathy should be considered as a mimic of spinal root compression.
Anaesthetic management for awake craniotomy in brain glioma resection: initial experience in Military Hospital Mohamed V of Rabat
Authors: Mohammed Meziane, Abdelghafour Elkoundi, Redouane Ahtil, Miloudi Guazaz, Bensghir Mustapha, Charki Haimeur
Journal: Pan Afr Med J (2017)
Keywords: awake craniotomy, brain glioma resection, control target infusion, laryngeal mask airway, scalp nerve block
MeSH terms: Anesthetics / administration & dosage, Brain Neoplasms / surgery, Craniotomy / methods, Glioma / surgery, Case Reports, Adult, Brain Neoplasms / pathology, Glioma / pathology, Hospitals, Military, Humans, Laryngeal Masks, Male, Morocco, Nerve Block / methods, Piperidines / administration & dosage, Remifentanil, Wakefulness, Anesthetics, Piperidines, Remifentanil

The awake brain surgery is an innovative approach in the treatment of tumors in the functional areas of the brain. There are various anesthetic techniques for awake craniotomy (AC), including asleep-awake-asleep technique, monitored anesthesia care, and the recent introduced awake-awake-awake method. We describe our first experience with anesthetic management for awake craniotomy, which was a combination of these techniques with scalp nerve block, and propofol/rémifentanil target controlled infusion. A 28-year-oldmale underwent an awake craniotomy for brain glioma resection. The scalp nerve block was performed and a low sedative state was maintained until removal of bone flap. During brain glioma resection, the patient awake state was maintained without any complications. Once, the tumorectomy was completed, the level of anesthesia was deepened and a laryngeal mask airway was inserted. A well psychological preparation, a reasonable choice of anesthetic techniques and agents, and continuous team communication were some of the key challenges for successful outcome in our patient.
Severe Late-Onset Drug-Induced Immune Thrombocytopenia Following IFN β-1a Treatment: A Case Report of a 52-Year-Old Woman with Relapse-Remitting Multiple Sclerosis
Authors: Christophe Cisarovsky, Marie Théaudin, Pierre-Alexandre Bart, Grégoire Stalder, Lorenzo Alberio
Journal: Case Rep Hematol (2022)
MeSH terms: Case Reports

Interferon β-1a (IFNβ1a) is considered safe in relapsing-remitting multiple sclerosis (RRMS). Drug-induced thrombocytopenia (DITP) is a rare but underreported adverse event that is often confused with other causes of thrombocytopenia. We report the case of a 52-year-old woman who developed limb and oral mucosa petechiae and hematochezia, 10 years after beginning IFNβ1a. Blood work showed an isolated severe thrombocytopenia and ruled out other autoimmune diseases, viral infections, intravascular hemolysis, and renal impairment. Oral corticosteroids and tranexamic acid were initiated with a favorable platelet response. IFNβ1a was resumed, leading to recurrence of thrombocytopenia. Platelets came back to normal after intravenous immunoglobulins and IFNβ1a was definitively discontinued. To our knowledge, this is the first case of drug-induced immune thrombocytopenia (DITP) associated with IFNβ1a.
Appendicitis in a Newborn: Case Report and Review of the Literature
Authors: Eleonora Ivanova, Rasa Garunkštienė, Arūnas Liubšys
Journal: Acta Med Litu (2022)
Keywords: nicu, appendicitis with perforation, neonatal appendicitis
MeSH terms: Case Reports

Background:
Acute appendicitis in a newborn is rare and may be fatal. The reported incidence is 0,04 % to 0,2 %. Diagnosis remains challenging as the symptoms are undefined.
Case presentation:
Here we present a full-term newborn boy of 9 days presenting with malaise, reluctance to feed and subfebrile fever. Over the course of 6 days his condition became worse. The newborn was febrile, passed no stool and his stomach became distended. Perforation due to necrotizing enterocolitis was highly suspected. The diagnosis of acute appendicitis was finalized perioperatively after the perforation and worsening condition made the emergency surgery inevitable. After 16 days of admission the patient was discharged in good condition.
Conclusion:
Appendicitis in neonates is a dangerous yet manageable condition. While rare it should be included in differential diagnosis when presented with atypical necrotizing enterocolitis or unexplained peritonitis. Quick and accurate diagnosis may increase survival rates.
Preoperative diagnosis of a mediastinal granular cell tumor by EUS-FNA: a case report and review of the literature
Authors: Sarah M Bean, Mohamad A Eloubeidi, Isam A Eltoum, Robert J Cerfolio, Darshana N Jhala
Journal: Cytojournal (2005)

We report the first case of a posterior mediastinal granular cell tumor initially diagnosed on cytologic material obtained via endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) in a 51-year-old male with a prior history of colon cancer. Aspirates obtained were cellular and composed of polygonal cells with abundant granular cytoplasm and small, round dark nuclei. An immunoperoxidase stain performed on the cell block for antibodies to S-100 protein showed strong, diffuse staining of the cytoplasmic granules. Electron microscopy performed on the cell block revealed numerous cytoplasmic lysosomes. This is the first case report in the English literature of a definitive preoperative diagnosis of a mediastinal granular cell tumor utilizing material obtained via EUS-FNA.
Generalized seizure in a Mauritian woman taking bupropion
Authors: Marie France Lan Cheong Wah, Lan Sem Hing Lan Cheong Wah
Journal: PLoS Med (2004)
MeSH terms: Bupropion / adverse effects, Dopamine Uptake Inhibitors / adverse effects, Seizures / chemically induced, Case Reports, Adult, Bupropion / therapeutic use, Dopamine Uptake Inhibitors / therapeutic use, Female, Humans, Smoking Cessation, Dopamine Uptake Inhibitors, Bupropion

A 24-y-old woman was admitted to the emergency department having had a generalized seizure (acute loss of consciousness, convulsive movements of her arms and legs, and confusion on regaining consciousness). She was on the sixth day of treatment with 300 mg daily of slow-release bupropion (Zyban SR) as an aid to smoking cessation. She had a past medical history of tonsillectomy and hay fever, for which she was taking budesonide nasal drops (two drops daily, each drop 200 mcg). She was on no other medication. There was no history of head trauma, liver disease, or alcohol withdrawal. Clinical examination, including neurological examination, was normal. The patient's weight was 48 kg. Her blood pressure was 130/80 mm Hg. Electrocardiogram showed a sinus tachycardia at 102 beats per minute. Radiography of the skull and a computed tomography scan of the brain without contrast were both normal. The patient's blood glucose, urea, electrolytes, and liver function tests were all normal. Her serum calcium was 2.01 mmol/l (normal range, 2.0–2.6 mmol/l) and her hemoglobin was 116 g/l (normal range, 120–140 g/l). The bupropion was discontinued, and the patient recovered without any further seizures or other neurological sequelae.