OpenMed/multicare-articles huggingface dataset:
Large Cell Calcifying Sertoli Cell Tumor with Macrocalcification in a Partially Resected Testis
Authors: Mahmoud Bardisi, Mohamad Nidal Khabaz, Jaudah Ahmad Al-Maghrabi
Journal: Case Rep Pathol (2020)
MeSH terms: Case Reports

Large cell calcifying Sertoli cell tumors (LCCSCTs) are extremely rare, with less than 100 tumors being described to date. Most of the tumors are benign with a few malignant cases, and aggressive behavior is infrequent. These tumors are a type of Sertoli cell tumor, and these tumors comprise less than 0.3% of all testis tumors in Saudi Arabia. They usually occur in boys and young adults and can affect one or both testicles in multifocal form causing microcalcifications. A 28-year-old male visited our hospital with left testis pain. Physical examination of the scrotum revealed that both testicles were normal sized with no palpable mass. Ultrasonography evaluation revealed grade 3 left varicocele and an incidental 9 mm calcified mass in the right testicle, which was further confirmed by MRI. Partial orchiectomy was performed. Clinical data, radiological studies, and morphological and immunohistochemical characteristics were analyzed.
Sanjad-sakati syndrome and its association with superior mesenteric artery syndrome
Authors: Osamah Abdullah AlAyed
Journal: Case Rep Pediatr (2014)

Sanjad-Sakati syndrome (SSS) is an autosomal recessive disorder found exclusively in people of Arabian origin. It was first reported in the Kingdom of Saudi Arabia in 1988 and confirmed by a definitive report in 1991. The syndrome comprises of congenital hypoparathyroidism, seizures, severe growth and developmental retardation, low IQ, and atypical facial features. Supportive treatment in the form of vitamin D and growth hormone supplementation is often offered to patients suffering from SSS. This case study focuses on the steps taken to help a patient who was found to have very unusual symptoms and was later found to have superior mesenteric artery syndrome.
A Case of Terbinafine-Resistant Tinea Cruris Caused by Trichophyton tonsurans
Authors: Alireza Firooz, Ensieh Lotfali, Mahsa Fattahi, Maryam Fattahi, Akram Miramin Mohammadi, Mahshid Shahrzad Kavkani
Journal: Case Rep Dermatol Med (2021)
MeSH terms: Case Reports

A 26-year-old male patient referred to our center with a history of extremely itchy crusted skin lesions in his groins for one year. Moreover, his friend, a 25-year-old male, also developed similar lesions in the groin after using the shared pool, whose condition also did not improve with similar treatment. A regular mycology test (direct and culture test) was performed, as well as molecular examination. The antifungal susceptibility assay to terbinafine, itraconazole, posaconazole, fluconazole, and voriconazole was conducted according to the Clinical and Laboratory Standards Institute M38 third ed. The sequencing study identified T. tonsurans as the causative organism in both patients. The abovementioned organism isolated from both patients displayed resistance against terbinafine and fluconazole (MIC ≥ 4 µg/ml and MIC ≥ 8 µg/ml, respectively). Moreover, the susceptibility of both subjects to posaconazole (0.313 µg/ml), voriconazole (0.25-0.0625 µg/ml), and (1 µg/ml) itraconazole increased. The present report aimed to emphasize the increase in antifungal resistance and a demand for antifungal stewardship, to control this public health threat.
Compromised longevity due to Mycobacterium abscessus pulmonary disease in lungs scarred by tuberculosis
Authors: Urvashi B Singh, Rojaleen Das, Prajowl Shrestha, Kiran Bala, Pooja Pandey, Santosh Kumar Verma, Hitender Gautam, Elizabeth Story-Roller, Gyanu Lamichhane, Randeep Guleria
Journal: Access Microbiol (2019)
Keywords: m abscessus, faropenem, pulmonary disease, tuberculosis
MeSH terms: Case Reports

Structural lung diseases or scarring related to prior infections such as tuberculosis (TB) are risk factors for the development of invasive nontuberculous mycobacterial (NTM) pulmonary infections, such as Mycobacterium abscessus . M. abscessus is intrinsically resistant to many antibiotics and in vitro susceptibility correlates poorly with clinical response, especially in pulmonary disease. Treatment is often difﬁcult due to the lack of effective antibiotic regimens. We present a case of a 56-year-old male previously treated for TB, with presumed exacerbation, who was diagnosed after much delay with pulmonary M. abscessus disease and subsequently failed initial treatment with an empirical antibiotic regimen. When placed on a synergistic combination regimen that included amikacin, linezolid, clarithromycin, ethambutol and faropenem, the patient showed a favourable response and was culture-negative for over 12 months when the treatment was stopped as per American Thoracic Society (ATS) recommendations. Unfortunately, he developed recurrent symptoms and died 9 months after stopping treatment, following an acute exacerbation of fever and respiratory failure.
Endovascular Repair of Persistent Sciatic Artery With Limb Ischemia: A Wrong Choice?
Authors: Liming Deng, Zhihe Deng, Kaiyu Chen, Ziyan Chen, Gang Chen, Guozuo Xiong
Journal: Front Surg (2020)
Keywords: endovascular repair, limb ischemia, malformation, persistent sciatic artery, thromboembolism
MeSH terms: Case Reports

Objectives: Persistent sciatic artery (PSA) is a rare congenital malformation that could lead to serious complications such as lower extremity ischemiais. We report the treatment of a PSA patient combined with limb ischemia. Methods: A 64-year-old man was admitted to the hospital for intermittent claudication of the right lower limb. The right ankle-brachial index (ABI) was 0.5. Computed tomography angiography (CTA) revealed the presence of an incomplete PSA with an absence superficial femoral artery. We performed catheter-directed thrombolysis (CDT) and stenting placement for the patient. Results: The vessels were successfully opened, and the claudication was resolved. However, half a year after the operation, the right PSA of the patient was occluded. Conclusion: The etiology, pathophysiology, and anatomic factors should be considered in the treatment of PSA. Endovascular treatment, bypass surgery, and drug therapy should be balanced. Improper choice of any treatment regimen may result in poor prognosis.
Photodynamic therapy for Basal cell carcinoma in recessive dystrophic epidermolysis bullosa
Authors: Myn Wee Lee, George Varigos, Peter Foley, Gayle Ross
Journal: ISRN Dermatol (2011)
MeSH terms: Case Reports

A 22-year-old male with recessive dystrophic epidermolysis bullosa with a large superficial and nodular basal cell carcinoma on his right forehead was treated with photodynamic therapy. The treatment was well tolerated, and the site healed well. Patients with epidermolysis bullosa are at increased risk of developing skin cancers, particularly squamous cell carcinomas. However, basal cell carcinomas are rare in recessive dystrophic epidermolysis bullosa. As patients with epidermolysis bullosa have recurrent blistering and poor wound healing, surgery may not be the optimal choice in treating skin cancers. We present this case to highlight that photodynamic therapy may be a helpful and safe technique in the treatment of superficial skin cancers in patients with epidermolysis bullosa, as an alternative to more radical methods.
Microbiological and Clinical Aspects of Raoultella spp
Authors: Tobias M Appel, Natalia Quijano-Martínez, Elsa De La Cadena, María F Mojica, María Virginia Villegas
Journal: Front Public Health (2021)
Keywords: enterobacteriaceae, maldi-tof, raoultella electrica, raoultella ornithinolytica, raoultella planticola, raoultella terrigena
MeSH terms: Enterobacteriaceae Infections / diagnosis, Review, Humans, Klebsiella

The genus Raoultella was established in 2001. Species of Raoultella and Klebsiella share many ecological, biochemical, clinical, and microbiological features. Given the shortcomings of available technology for species identification in the clinical microbiology laboratory, are practically indistinguishable. Since the late 2000s there has been an increase in case reports of human Raoultella infections. Therefore, several authors are postulating that Raoultella spp. are rare and/or emerging pathogens. Conclusions:Raoultella spp. are very similar to Klebsiella spp. The epidemiology and the clinical relevance of the human Raoultella spp. infections is uncertain and further studies are required. The previous difficulties in the identification of Raoultella spp. and the introduction of more precise identification techniques may explain the recent increase in the number of case reports. Raoultella spp. might be rather underdiagnosed than rare or emerging pathogens.
Asymptomatic presentation of aggressive ossifying fibroma:a case report
Authors: Roopashri Rajesh Kashyap, Gopakumar R Nair, Subhas Babu Gogineni
Journal: Case Rep Dent (2011)
MeSH terms: Case Reports

Ossifying fibromas form a part of the spectrum of fibro-osseous lesions of the jaws. They are rare, benign, nonaggressive tumors that are commonly seen in head and neck region. This paper presents the case of a 40-year-old female patient presented with minimal clinical symptoms, diagnosed to be suffering from aggressive form of ossifying fibroma of maxilla involving the maxillary sinus and ethmoid sinus. This paper emphasizes the importance of computed tomography in diagnosing such unapparent aggressive tumors.
Polymorphic Ventricular Tachycardia Associated with High-Dose Methadone Use
Authors: Weng-Chio Tam, U-Po Lam, Toi-Meng Mok, Tou Chang, Wa Ho, Mario Alberto De Brito Lima Evora
Journal: Case Rep Cardiol (2020)
MeSH terms: Case Reports

Methadone is a well-tolerated drug that has been used for pain control and the treatment of opioid addiction. However, some fatal cardiac side effects have been reported previously, including ventricular arrhythmia, stress cardiomyopathy, and coronary artery disease. We reported a middle-aged woman receiving high-dose methadone whom was presented with QT prolongation and torsade de pointes. We replaced the methadone with benzodiazepine and gave lidocaine use simultaneously. Thus, QT interval was shortened within the normal limit. Methadone-induced torsade de pointes is a rare but serious event, and QT interval should be monitored periodically to prevent this fatal adverse event, especially some patients with high-dose methadone use.
Sepsis-like histoplasmosis in a kidney transplant patient
Authors: Ana Raquel Fernandes, Laila Almeida Viana, Juliana Busato Mansur, Mariana de Moraes Françoso, Daniel Wagner de Castro Lima Santos, Helio Tedesco Silva, José Osmar Medina Pestana
Journal: J Bras Nefrol (2018)
MeSH terms: Histoplasmosis / diagnosis, Histoplasmosis / drug therapy, Kidney Transplantation, Postoperative Complications / diagnosis, Postoperative Complications / drug therapy, Sepsis / diagnosis, Sepsis / drug therapy, Case Reports, Fatal Outcome, Female, Humans, Middle Aged

Histoplasmosis is a fungus infection that mainly affects immunosuppressed patients. The authors present a case of a kidney transplant recipient who developed sepsis-like histoplasmosis, na atypical but severe manifestation of the disease. The fungus was found in blood and in a skin biopsy, and the treatment with liposomal amphotericin resulted in hepatotoxicity.
The delivery of radical radiotherapy to the bladder and pelvis in node-positive (N1) bladder cancer: a five patient case series
Authors: David Gareth Fackrell, Daniel Ford, Shan Chetiyawardana, Samantha Austin, Nicholas James
Journal: BJR Case Rep (2016)

In the UK over 10,000 new cases of bladder cancer were diagnosed in 2012, making it the seventh most common cancer in the UK. For those with advanced disease at presentation, prognosis is poor. Disease presenting with one pathological node (N1) is considered to be Stage 4 and is therefore considered the same as disease with widespread metastases. Pelvic lymph node dissection is considered standard when performing radical cystectomy; however, owing to potential toxicity, pelvic radiotherapy is not routine even when attempting radical treatment. We present five cases where radical treatment has been delivered to patients with node-positive bladder cancer. Treatment volumes included the whole bladder and bilateral pelvic nodes, and where it was felt appropriate, chemotherapy was delivered concurrently. Data has been collected by reviewing hospital notes including radiotherapy, volumes and dose distributions. Treatment was tolerated well with only minimal gastrointestinal and urinary symptoms reported. Three of the five patients had thrombocytopenia. This complication may be explained by the larger volume of radiation exposure. Local control appears to be good with all the patients having no pelvic relapse at the time of reporting. Two patients have relapsed with distant metastatic disease. No long-term side effects of therapy have been reported. Intensity-modulated radiotherapy techniques allow larger volumes to be treated owing to improved conformality and the resulting reduced toxicity. Treatment may be appropriate with both radical and adjuvant doses of radiation. More work is necessary to assess which patients would benefit and are most suitable for such treatment.
Severe burn injury in late pregnancy: a case report and literature review
Authors: Yan Shi, Xiong Zhang, Bo-Gao Huang, Wen-Kui Wang, Yan Liu
Journal: Burns Trauma (2015)
Keywords: burn, fluid resuscitation, pregnancy
MeSH terms: Review

The management of serious burn injuries during pregnancy is an unsolved clinical problem because of the low incidence of this disease. Although it has been documented that the effect of burns on fetal and maternal survival is detrimental, there have been conflicting reports among the different burn centers regarding the mortality of burned pregnant women and the management of burn patients during pregnancy. We report a case of severe burn in late pregnancy treated at our burn center. Additionally, we searched and summarized the literature concerning the management of pregnant patients to provide useful information for their treatment.
A preterm infant with semilobar holoprosencephaly and hydrocephalus: a case report
Authors: Ashish O Gupta, Patrick Leblanc, Krishna C Janumpally, Pattaraporn Tanya
Journal: Cases J (2010)

Introduction:
Holoprosencephaly (HPE) is a rare presentation in newborns. It refers to an incomplete or absent division of the prosencephalon or forebrain into distinct cerebral hemispheres.
Case presentation:
A preterm baby girl, first of dizygotic twins, born at 26 weeks of gestation to a 45 year old mother, was prenatally diagnosed with ventriculomegaly on fetal ultrasonogram. At birth the baby had frontal bossing with sun setting eyes and a full anterior fontanel. Initial head ultra-sonography (HUS) showed ventriculomegaly and semilobar holoprosencephaly, which was confirmed by computed tomography scan. Subsequently, the baby developed hydrocephalus that progressively increased. Eventually, the cerebrospinal fluid required drainage and a ventriculo-peritoneal shunt was placed.
Conclusion:
Holoprosencephaly has heterogeneous etiologies, including teratogenic and or a genetic basis. It is prudent to diagnose holoprosencephaly prenatally and determine the type to classify severity, complications and survival rate. It is also important to recognize that even with monozygotic twins only one twin may have HPE. The parents of a baby diagnosed with holoprosencephaly should be counseled about the poor prognosis.
Chilaiditi Syndrome: A Case Report Highlighting the Intermittent Nature of the Disease
Authors: Esha M Kapania, Christina Link, Joshua M Eberhardt
Journal: Case Rep Med (2018)
MeSH terms: Case Reports

Background:
Chilaiditi syndrome is a phenomenon where there is an interposition of the colon between the liver and the abdominal wall leading to clinical symptoms. This is distinct from Chilaiditi sign for which there is radiographic evidence of the interposition, but is asymptomatic.
Case presentation:
Here, we present the case of a patient who, despite having clinical symptoms for a decade, had a delayed diagnosis presumably due to the interposition being intermittent and episodic.
Conclusions:
This case highlights the fact that Chilaiditi syndrome may be intermittent and episodic in nature. This raises an interesting question of whether previous case reports, which describe complete resolution of the syndrome after nonsurgical intervention, are perhaps just capturing periods of resolution that may have occurred spontaneously. Because the syndrome may be intermittent with spontaneous resolution and then recurrence, patients should have episodic follow-up after nonsurgical intervention.
Retinoschisis transposition following a retinal detachment repair
Authors: Katherine McVeigh, Johannes Keller, Richard J Haynes
Journal: GMS Ophthalmol Cases (2015)
Keywords: retinal detachment, retinoschisis, transposition, vitrectomy
MeSH terms: Case Reports

Objective:
The authors have observed this phenomenon of translocation of the schisis cavity in a few previous cases and aim to report this unusual finding.
Method:
A patient with known superotemporal retinoschisis developed a distinctly separate inferotemporal retinal detachment in his left eye. This was repaired with a vitrectomy, cryotherapy and C2F6 tamponade under local anaesthetic. Following surgery, the retinoschisis was found in the inferonasal quadrant of the eye and remained stable as the gas dispersed.
Result:
We hypothesise that the tamponading agent compressed the viscous fluid within the area of schisis, displacing the area of schisis circumferentially.
Conclusion:
This case emphasises that as long as the retinal breaks are properly sealed, no intervention is required with the schisis during rhegmatogenous retinal detachment surgery.
Hybrid Solution for Mycotic Pseudoaneurysm of Carotid Bifurcation
Authors: Giuseppe Deiana, Antonio Baule, Genadi Genadiev Georgiev, Mario Moro, Francesco Spanu, Flavia Urru, Stefano Camparini
Journal: Case Rep Vasc Med (2020)
MeSH terms: Case Reports

Mycotic pseudoaneurysms of the extracranial carotid artery are rare and need surgical treatment to prevent rupture or embolization. We treated a case of a carotid bifurcation pseudoaneurysm secondary to infection caused by Staphylococcus epidermidis. We successfully treated it using a catheter balloon to obtain carotid bifurcation's control and replacing the carotid bifurcation with a vein graft. Management involves aneurysmectomy associated with antibiotic therapy and restoration of arterial continuity.
Psoriasis vulgaris flare during efalizumab therapy does not preclude future use: a case series
Authors: Michelle A Lowes, James A Turton, James G Krueger, Ross St C Barnetson
Journal: BMC Dermatol (2005)
MeSH terms: Antibodies, Monoclonal / therapeutic use, Immunologic Factors / therapeutic use, Lymphocyte Function-Associated Antigen-1 / immunology, Psoriasis / drug therapy, Case Reports, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S., Adult, Antibodies, Monoclonal, Humanized, Arthritis, Psoriatic / drug therapy, CD11 Antigens, Female, Humans, Male, Middle Aged, Patient Compliance, Psoriasis / immunology, Secondary Prevention, Antibodies, Monoclonal, Antibodies, Monoclonal, Humanized, CD11 Antigens, Immunologic Factors, Lymphocyte Function-Associated Antigen-1, efalizumab

Background:
Severe psoriasis vulgaris can be extremely difficult to treat in some patients, even with the newer biological therapies available today.
Case presentations:
We present two patients with severe chronic plaque psoriasis who received numerous systemic anti-psoriatic therapies with varied results. Both responded well to initial treatment with efalizumab (anti-CD11a), but then experienced a flare of their disease after missing a dose. However, after disease stablization, both patients responded well to re-introduction of efalizumab, one patient requiring concurrent treatment with infliximab (anti-TNF-alpha).
Conclusion:
These cases are presented to characterize this "flare" reaction, and to inform health care providers that efalizumab can still be administered after disease flare, and again may be a successful therapy.
Acquired Immunodeficiency Syndrome Presented as Atypical Ocular Toxoplasmosis
Authors: Elias Khalili Pour, Hamid Riazi-Esfahani, Nazanin Ebrahimiadib, Violet Zaker Esteghamati, Mohammad Zarei
Journal: Case Rep Ophthalmol Med (2021)
MeSH terms: Case Reports

Background:
The aim is to report an atypical presentation of ocular toxoplasmosis which led to the diagnosis of Acquired Immunodeficiency Syndrome (AIDS). Case Report. The 38-year-old woman was referred with metamorphopsia and reduced vision in the right eye over the past 3 weeks. Slit-lamp examination revealed granulomatous keratic precipitates (KPs), 2+ cells in the anterior chamber, and posterior synechiae. Fundus examination was remarkable for a white patch surrounding a scar, inferonasal to the optic disc with fibrous bands emanating from the lesion, and the retina around this region was detached with considerable extension towards the periphery, while no breaks could be appreciated. She mentioned anorexia and losing 10 kg in the past three months, and signs of anemia like paleness of face skin, bed nails, and bilateral angular cheilitis were observed on systemic evaluation. The results of the patient's complete blood count revealed anemia and leukopenia and CD4 lymphocytes: 79 cells/μL. Enzyme-linked immunosorbent assays (ELISA) for HIV antibodies came back positive which was later confirmed with the Western blot test. Brain magnetic resonance imaging (MRI) showed multiple ring-enhancing lesions in both cerebral cortices. The patient underwent antitoxoplasmosis and anti-HIV treatment and serous retinal detachment completely resolved.
Conclusion:
This report highlights the fact that sometimes, the eyes are the site of the first presentation of a systemic life-threatening condition and emphasizes the role of ophthalmologists in such cases. In cases of atypical presentation, appropriate laboratory tests and CNS imaging should be requested. Systemic treatment with antitoxoplasmosis regimens and highly active antiretroviral therapy (HAART) is mandatory in AIDS patients with ocular toxoplasmosis.
Case report: Subacute transverse myelitis with gait preservation secondary to Lyme disease and a review of the literature
Authors: Charlotte Colot, Catherine Adler, Céline Mignon, Alessandro De Leucio, Patrice Jissendi, Jean Fonteyne, Alec Aeby
Journal: Front Pediatr (2023)
Keywords: lyme disease (ld), gait preservation, review, subacute, transverse myelitis (tm)
MeSH terms: Case Reports

Subacute presentation with gait preservation is rare in the initial presentation of transverse myelitis (TM) in children. Lyme TM is poorly described in the literature. Here, we present the case of a 10-year-old boy who presented with neck pain with irradiation in the upper limbs for 13 days, accompanied by a right latero-torticollis. Magnetic resonance imaging (MRI) of the spine showed a hypersignal in the centromedullary T2 weighted image (WI) between C1 and C7, which was suggestive of cervical TM. A lumbar puncture revealed pleocytosis and proteinorachia. The test results of Borrelia IgG in the blood and intrathecal IgG synthesis were positive, confirming the diagnosis of TM secondary to Lyme disease. The patient was treated with high doses of steroids and antibiotics, following which he recovered completely. After a review of the clinical features of the eight previously published pediatric cases, we can conclude that Lyme TM usually has a subacute clinical presentation and is frequently limited to the cervical spine with pure sensory symptoms and gait preservation. Moreover, acute and chronic sphincter dysfunction is rare, and recovery is usually complete.