OpenMed/multicare-articles huggingface dataset:
Sulfadiazine-Induced Obstructive Nephropathy Presenting with Upper Urinary Tract Extravasation
Authors: Maharan Kabha, Snir Dekalo, Sophie Barnes, Ishay Mintz, Haim Matzkin, Mario Sofer
Journal: J Endourol Case Rep (2016)
Keywords: extravasation, hydronephrosis, obstructive uropathy, sulfadiazine
MeSH terms: Case Reports

Background: Obstructive nephropathy is an uncommon side effect of sulfadiazine, which is used for the treatment of toxoplasmosis. We present a case of acute renal colic and urine extravasation of a patient shortly after she was started on this medication. Case Presentation: A 31-year-old female presented with acute renal colic 2 weeks after starting treatment with sulfadiazine and pyrimethamine for ocular toxoplasmosis. Results: A noncontrast computed tomography revealed left hydronephrosis and fluid located around the kidney and in the left gutter. There were no urinary stones. Administration of intravenous contrast revealed significant urine extravasation at the level of the ureteropelvic junction. Intravenous contrast injection confirmed that the extravasation consisted of urine leakage at the ureteropelvic junction. Her clinical condition improved with the insertion of an internal stent, which was left in place for 4 weeks. A retrograde pyelography performed at the time of the internal stent removal ruled out persistent extravasation and filling defects in the left upper urinary tract. Considering the clinical circumstances and the imaging results, it appears that this is a first reported case of sulfadiazine-induced obstructive uropathy associated with urine extravasation. Conclusion: Although rare, obstructive uropathy related to sulfadiazine medication should be promptly suspected, diagnosed, and treated. Patients should be instructed to substantially increase their liquid intake while on that medication.
Non-Union of Isolated Medial Condyle of Femur Hoffa Fracture: Case Report
Authors: Mukund Pai Manjeswar, Amit Kale, Harsh Raithatha, Shail Shah
Journal: Cureus (2023)
Keywords: femur, fracture, hoffa, non-union, trauma
MeSH terms: Case Reports

Isolated non-united Hoffa fracture of the femur is a rare finding. They are often missed due to the nature of the fracture and when not assessed appropriately. This is a case report of a 40-year-old male who encountered a high-velocity trauma; the fracture was probably missed on plain radiographs following the trauma. The patient presented to us eight months following the trauma with complaints of pain and decreased range of motion of his right knee (10 to 80 degrees of flexion) and the patient was unable to bear weight on the affected limb. On evaluation, the patient was found to have a non-united Hoffa fracture involving the medial condyle. The patient was treated with freshening of fracture followed by rigid fixation with cancellous screws and reconstruction plate. Postoperatively by week six, the patient achieved full range of motion and was able to walk without assistance with evidence of union on plain radiographs.
A case report of multi-compartmental lipoma of the hand
Authors: Maria A Bocchiotti, Arianna B Lovati, Loris Pegoli, Giorgio Pivato, Alessandro Pozzi
Journal: Case Reports Plast Surg Hand Surg (2018)
Keywords: lipoma, hand tumor, multi-compartmental mass
MeSH terms: Case Reports

This report shows a multi-compartmental lipoma that occupied a vast area of the hand volar compartment, the distal aspect of the Parona's space and infiltrated the dorsal compartment between the IV and V metacarpal bones. The mass was entirely removed through a dorsal approach, minimizing risks of neurovascular and tendinous lesions.
Primary breast T-cell lymphoma, unspecified, treated with autologous peripheral blood stem cell transplantation: A case report and literature review
Authors: Qiqi Gao, Xiuming Zhang, Hua Xiang, Guoping Ren, Yulong Zheng
Journal: Oncol Lett (2014)
Keywords: t-cell lymphoma, breast, immunohistochemistry, recurrence

The current study presents a case of primary T-cell lymphoma (PTBL), unspecified, in a 27-year-old female. The patient received chemotherapy [cyclophosphamide, epirubicin, vindesine and prednisolone (CHOP) and VP-16 plus CHOP (ECHOP)] and autologous peripheral blood stem cell transplantation, however, relapse occurred rapidly. The recurrent tumor exhibited increased levels of karyopyknosis and nuclear fragmentation and a higher Ki67 index compared with the primary tumor. No response to subsequent chemotherapy, including ECHOP and gemcitabine, dexamethasone and cisplatin, was observed. The patient succumbed to PTBL, unspecified, 18 months after the diagnosis. We hypothesize that autologous peripheral blood stem cell transplantation is ineffective for PTBL.
Vascular graft infection due to Pasteurella multocida
Authors: F Fourreau, F Méchaï, J Brossier, O Bouchaud, B Picard
Journal: Springerplus (2015)
Keywords: graft infection, pasteurella multocida, vascular graft

Background:
Vascular graft infections are infrequent complications with important morbidity and mortality rates. Pasteurella multocida, a Gram negative bacillus, is a normal oral commensal of many animals. For mankind, it is a pathogenous bacillus which is rarely implicated in vascular grafts.
Case report:
We report hereafter the fourth case introduced in the international literature about vascular graft infections caused by P. multocida. The patient was successfully treated with a combination of a surgical graft change and a 6 weeks bi-antibiotic therapy.
Discussion:
There is fours case reported in litterature with quite different antibiotic drugs and duration.
Conclusion:
P. multicoda graft infection should be long with initial intravenous drug and mainteance traitement should not be required.
Cecal Intussusception Diagnosed by Total Colonoscopy in a Child: A Case Report
Authors: Toshihiko Kakiuchi, Motohiro Esaki, Aiko Nakayama, Fumio Ichinose, Muneaki Matsuo
Journal: Front Pediatr (2020)
Keywords: child, computed tomography, intussusception, lead point, total colonoscopy
MeSH terms: Case Reports

Background: Ileocolic intussusception is the most common form of intussusception in children. Intussusception in the appendix or cecum without a lead point in a child is very rare and was found with total colonoscopy (TCS) and computed tomography. Case Presentation: A 9 year-old boy was admitted to our hospital with fever, vomiting, and two episodes of bloody diarrhea. Inflammatory bowel disease was suspected; TCS was performed and revealed intussusception whose advanced region was in the cecum. The diagnosis was idiopathic cecum intussusception. This case was unusual in that intussusception had occurred at a young age but without lead point; in addition, the intussusception had also occurred at the tip of the cecum. The intussusception was safely reduced by endoscopic procedures, and after improvement in the vomiting, the patient was safely discharged and has had no bloody stools since. Conclusion: We demonstrated cecal intussusception without lead point observed on TCS in a child.
Strokectomy and Extensive Cisternal CSF Drain for Acute Management of Malignant Middle Cerebral Artery Infarction: Technical Note and Case Series
Authors: Fulvio Tartara, Elena Virginia Colombo, Daniele Bongetta, Giulia Pilloni, Carlo Bortolotti, Davide Boeris, Francesco Zenga, Alessia Giossi, Alfonso Ciccone, Maria Sessa, Marco Cenzato
Journal: Front Neurol (2019)
Keywords: basal cisterns opening, cerebrospinal fluid drainage, ischemic stroke, malignant mca stroke, strokectomy

Background and Purpose: Ischemic stroke is a major cause of death and disability worldwide. Large MCA stroke may evolve as malignant space occupying lesion and mortality rate reaches 80% despite maximal medical therapy. Early decompressive craniectomy is effective in reducing mortality and improving the functional outcome but is an extended and invasive surgical approach burdened with a significant complication rate. We report a surgical treatment based on partial strokectomy and basal cisterns opening with massive CSF drain. Materials and Methods: We retrospectively collected 15 cases of massive middle cerebral artery stroke treated with strokectomy between 2010 and 2017: nine males and six females, mean age 61.73 ± 9.5 years. The right side was affected in 66.7%. All patients show clinical deterioration despite standard medical therapy and indication for surgery was placed after collegiate evaluation by neurologists and neurosurgeons based on clinical and radiological data. Results: Surgical procedure was performed 24-96 h after the stroke onset. All the 15 patients survived the intervention, one patient died 20 days after the admission for massive lung embolism. Mean GCS and NIHSS at admission were 12.6 ± 1.18 (range 9-15) and 19.7 ± 2.3 (range 18-23), respectively. Mean mRS at 12 months was 3.6 ± 1.1 (range 2-6). Mean follow-up was 18.1 months (range 12-34). The outcome was evaluated as satisfactory (mRs ≤ 3) in 8 patients (53.3%). Mortality at 1 year was 6.7%. No patients developed hydrocephalus and 1 presented seizures. According to mRs outcome evaluation (mRs ≤ 3 vs. mRs ≥ 4) no quantitative variable resulted significantly different between the two groups, whereas the concomitant use of iv rTPA significantly differed (P < 0.05). Conclusion: Supratentorial strokectomy seems to be safe and could be a potential alternative to decompressive craniectomy for the acute management of malignant MCA stroke. Advantages of this approach could be low complication rate, avoidance of bone reconstruction procedure, and reduced occurrence of hydrocephalus or seizures. A co-operative multicentric, prospective pilot study will be necessary to validate this technical approach.
Two Refractory Immune Thrombocytopenia Case Reports Showing Responsiveness to Fostamatinib
Authors: Vanessa Innao, Rosalba Donatella Calogero, Fabrizio Lo Presti, Ugo Consoli
Journal: Case Rep Hematol (2023)
MeSH terms: Case Reports

Immune thrombocytopenia (ITP) is immune-mediated platelet loss due to increased destruction and insufficient production. Treatment guidelines provide for first-line steroid-based therapies followed by thrombopoietin receptor agonists (TPO-RAs) and fostamatinib for chronic ITP. Fostamatinib demonstrated efficacy in phase 3 FIT trials (FIT1 and FIT2) mainly in second-line therapy resulting in the maintenance of stable platelet values. Here, we describe two patients with extremely heterogeneous characteristics that responded to fostamatinib after two and nine previous treatments. Responses were complete with stable platelet counts ≥50,000/μL and without any grade ≥3 adverse reactions. As in the FIT clinical trials, we confirm better responses to fostamatinib when used in the second or third line. However, its use should not be excluded in patients with longer and more complicated drug histories. Given the different mechanism of action of fostamatinib compared to TPO-RAs, it would be interesting to identify predictive factors of responsiveness applicable to all patients.
Toxic shock syndrome associated with menstrual cup use
Authors: Hind El Soufi, Yahya El Soufi, Sarah Al-Nuaimi, Farshad Bagheri
Journal: IDCases (2021)
Keywords: menstrual cup, staphylococcus aureus, toxic shock syndrome, vaginal cup
MeSH terms: Case Reports

Staphylococcal toxic shock syndrome is a rare but life-threatening condition. It occurs when Staphylococcus aureus bacteria colonizing the vagina of a healthy woman, produce toxic shock syndrome toxin 1 activating the immune system and leading to multiorgan failure. Menstrual cups also known as vaginal cups are usually used as alternatives to other intravaginal products for menstrual blood collection. In rare cases, they can also lead to toxic shock syndrome. We report a case of toxic shock syndrome associated with vaginal cup use in a healthy menstruating woman. The diagnosis was made based on the United States Centers for Disease Control and Prevention criteria of the syndrome and confirmed with a vaginal cultural growth of Staphylococcus aureus.
Sensorineural hearing loss in Lassa fever: two case reports
Authors: Peter O Okokhere, Titus S Ibekwe, George O Akpede
Journal: J Med Case Rep (2009)

Introduction:
Lassa fever is an acute arena viral haemorrhagic fever with varied neurological sequelae. Sensorineural hearing loss is one of the rare complications which occur usually during the convalescent stage of the infection.
Case presentation:
The cases of two female patients aged 19 and 43 years old, respectively, with clinical features suggestive of Lassa fever and confirmed by immunoserological/Lassa-virus-specific reverse transcriptase polymerase chain reaction are presented. Both patients developed severe sensorineural hearing loss at acute phases of the infections.
Conclusion:
Sensorineural hearing loss from Lassa fever infections can occur in both acute and convalescent stages and is probably induced by an immune response.
Transient Central Diabetes Insipidus after Discontinuation of Vasopressin
Authors: Nathaniel Carman, Carl Kay, Abigail Petersen, Maria Kravchenko, Joshua Tate
Journal: Case Rep Endocrinol (2019)
MeSH terms: Case Reports

Central diabetes insipidus (CDI) is an uncommon condition resulting from lack of vasopressin secretion from the posterior pituitary gland typically caused by some form of destruction of the gland. Here we present a case of transient CDI after discontinuation of vasopressin used for septic shock without evidence of overt pituitary damage. Serum sodium concentration peaked at 160 mmol/L in the setting of polyuria within days of vasopressin discontinuation without identified alternative etiologies. Sodium levels and urine output normalized with administration of desmopressin with continued stability after desmopressin was discontinued. This is one of few reported cases of diabetes insipidus occurring after discontinuation of vasopressin and the rapid and profound response to desmopressin in this case proves a central etiology. This case allows for speculation into predisposing risk factors for this phenomenon including preexisting neurological disease.
Massive ear keloids: Natural history, evaluation of risk factors and recommendation for preventive measures - A retrospective case series
Authors: Michael Tirgan
Journal: F1000Res (2016)
Keywords: cryotherapy, ear keloid

Keloid disorder (KD) is an inherited wound healing ailment, frequently seen among Africans /African Americans and Asians. Genetics of this disorder continues to be obscure and poorly understood. Clinical manifestation of KD is quite variable and very diverse, spanning from individuals with one or very few small keloidal lesions, to those with numerous and very large lesions covering large portion of their skin. Ears are common locations for development of keloids. Ear piercing is by far the leading triggering factor for ear keloid formation in genetically predisposed individuals. Although there are numerous publications about ear and earlobe keloids, there is a void in medical literature about massive ear keloids. This paper focuses on the natural history of massive ear keloids and risk factors that lead to formation of these life-changing and debilitating tumors and recommendations for prevention.
Unusual Bladder Metastasis from a Primary Gastric Carcinoma: Two Case Reports and Review of Literature
Authors: Mohamed Ali Nouioui, Ahmed Saadi, Marouene Chakroun, Amine Oueslati, Meriem Ksentini, Abderrazak Bouzouita, Amine Derouiche, Mohamed Riadh Ben Slama, Soumaya Rammeh, Haroun Ayed, Mohamed Chebil
Journal: Case Rep Urol (2020)
MeSH terms: Case Reports

Primary bladder cancer is a frequent malignancy in the urology field, whereas secondary bladder neoplasms from a distant organ are extremely rare. This paper aims to report two rare cases of a secondary tumor of the urinary bladder from a primary gastric tumor and to perform a literature review of similar reported cases in order to better characterize its clinicopathological features and diagnosis in effort to shed light on this rare condition. The final diagnosis of secondary adenocarcinoma was made histologically after transurethral biopsy or resection of the bladder lesion. In one case, the bladder metastasis was a synchronous metastasis, and in the second case, it occurred under chemotherapy five months after initial diagnosis with gastric adenocarcinoma. Secondary adenocarcinoma of the bladder is extremely rare but should be considered when evaluating a bladder lesion in a patient treated for gastric cancer or presenting with gastric symptoms.
Robot-Assisted Middle Ear Endoscopic Surgery: Preliminary Results on 37 Patients
Authors: Marine Veleur, Ghizlene Lahlou, Renato Torres, Hannah Daoudi, Isabelle Mosnier, Evelyne Ferrary, Olivier Sterkers, Yann Nguyen
Journal: Front Surg (2021)
Keywords: porp, torp, cholesteatoma, robot, robotics, safety, surgery, tympanoplasty

Background: Endoscopy during middle ear surgery is advantageous for better exploration of middle ear structures. However, using an endoscope has some weaknesses as surgical gestures are performed with one hand. This may trouble surgeons accustomed to using two-handed surgery, and may affect accuracy. A robot-based holder may combine the benefits from endoscopic exposure with a two-handed technique. The purpose of this study was to assess the safety and value of an endoscope held by a teleoperated system. Patients and Methods: A case series of 37 consecutive patients operated using endoscopic exposure with robot-based assistance was analyzed retrospectively. The RobOtol® system (Collin, France) was teleoperated as an endoscope holder in combination with a microscope. The following data were collected: patient characteristics, etiology, procedure type, complications, mean air and bone conduction thresholds, and speech performance at 3 months postoperatively. Patients had type I (myringoplasty), II (partial ossiculoplasty), and III (total ossiculoplasty) tympanoplasties in 15, 14, and 4 cases, respectively. Three patients had partial petrosectomies for cholesteatomas extending to the petrous apex. Finally, one case underwent resection of a tympanic paraganglioma. Ambulatory procedures were performed in 25 of the 37 patients (68%). Results: Complete healing with no perforation of the tympanic membrane was noted postoperatively in all patients. No complications relating to robotic manipulation occurred during surgery or postoperatively. The mean air conduction gain was 3.8 ± 12.6 dB for type I (n = 15), 7.9 ± 11.4 dB for type II (n = 14), and -0.9 ± 10.8 for type III tympanoplasties (n = 4), and the postoperative air-bone conduction gap was 13.8 ± 13.3 dB for type I, 19.7 ± 11.7 dB for type II and 31.6 ± 13.0 dB for type III tympanoplasty. They was no relapse of cholesteatoma or paraganglioma during the short follow-up period (<1 year). Conclusion: This study indicates that robot-assisted endoscopy is a safe and trustworthy tool for several categories of middle ear procedures. It combines the benefits of endoscopic exposure with a two-handed technique in middle ear surgery. It can be used as a standalone tool for pathology limited to the middle ear cleft or in combination with a microscope in lesions extending to the mastoid or petrous apex.
Case Report: 18F-PSMA PET/CT Scan in Castration Resistant Prostate Cancer With Aggressive Neuroendocrine Differentiation
Authors: Marco Bergamini, Alberto Dalla Volta, Irene Caramella, Luisa Bercich, Simona Fisogni, Mattia Bertoli, Francesca Valcamonico, Salvatore Grisanti, Pietro Luigi Poliani, Francesco Bertagna, Alfredo Berruti
Journal: Front Oncol (2022)
Keywords: psma - prostate specific membrane antigen, castration-resistance prostate cancer, crpc, neuroendocrine prostate cancer (nepc), small cell prostate cancer, theranostic psma radioligands
MeSH terms: Case Reports

The development of a neuroendocrine phenotype as a mechanism of resistance to hormonal treatment is observed in up to 20% of advanced prostate cancer patients. High grade neuroendocrine prostate cancer (NEPC) is associated to poor prognosis and the therapeutic armamentarium is restricted to platinum-based chemotherapy. Prostate-specific membrane antigen (PSMA)-based positron emission tomography (PET)/computed tomography (CT) imaging has recently emerged as a potential new standard for the staging of prostate cancer and PSMA-based radioligand therapy (RLT) as a therapeutic option in advanced metastatic castration resistant prostate cancer (mCRPC). PSMA-based theranostic is not currently applied in the staging and treatment of NEPC since PSMA expression on neuroendocrine differentiated cells was shown to be lost. In this case series, we present 3 consecutive mCRPC patients with histologically proven high grade neuroendocrine differentiation who underwent PSMA-PET/CT and surprisingly showed high tracer uptake. This observation stimulates further research on the use of PSMA-based theranostic in the management of NEPC.
Very late recurrence of Diethylstilbestrol - related clear cell carcinoma of the cervix: case report
Authors: Ablavi Adani-Ifè, Emma Goldschmidt, Pasquale Innominato, Ayhan Ulusakarya, Hassan Errihani, Philippe Bertheau, Jean François Morère
Journal: Gynecol Oncol Res Pract (2015)
Keywords: cervix, clear cell adenocarcinoma, diethylstilbestrol, recurrence
MeSH terms: Case Reports

Clear cell adenocarcinoma of the cervix is a rare tumor of the lower genital tract. It has been described in young women with a history of intra uterine exposure to diethylstilbestrol. This tumor is characterized by a greater tendency for late recurrences. In this article, we report the case of one exposed-patient who developed recurrence as liver metastases, 24 years after the initial treatment. This case demonstrates the need and the importance for continued follow-up in individuals prenatally exposed to diethylstilbestrol.
Open Achilles Tendon Rerupture: A Case Report and Review of the Literature
Authors: Michael E Doany, Megan C Paulus
Journal: Case Rep Orthop (2020)
MeSH terms: Case Reports

In this report, we describe a rare case of open rerupture of an Achilles tendon following primary surgical repair. The rerupture occurred 12 weeks postoperatively and was associated with a transverse open wound perpendicular to the original surgical incision. This complication was successfully managed utilizing the preexisting transverse wound and a minimally invasive repair technique, minimizing further risk to the soft tissues overlying the tendon. This rare complication has only been described a few times in the literature and is likely associated with adhesions between the tendon repair and the subcutaneous tissues.
Mycobacterium lentiflavum infection in immunocompetent patient
Authors: Chiara Molteni, Lidia Gazzola, Miriam Cesari, Alessandra Lombardi, Franco Salerno, Enrico Tortoli, Luigi Codecasa, Valeria Penati, Fabio Franzetti, Andrea Gori
Journal: Emerg Infect Dis (2005)
MeSH terms: Immunocompetence, Lung Diseases / microbiology, Mycobacterium / pathogenicity, Mycobacterium Infections / microbiology, Case Reports, Research Support, Non-U.S. Gov't, Review, Aged, Chronic Disease, Female, Humans, Lung Diseases / diagnosis, Male, Mycobacterium Infections / diagnosis

Mycobacterium lentiflavum is a recently described nontuberculous mycobacterium that has mainly clinical importance in young children with cervical lymphadenitis and in immunocompromised patients. We describe a case of chronic pulmonary infection in an immunocompetent patient. Our observation confirms clinical, diagnostic, and treatment difficulties in the management of M. lentiflavum infection.