OpenMed/multicare-articles huggingface dataset:
Nodular Lymphocyte-Predominant Hodgkin Lymphoma in Progressive Transformation of Germinal Centers
Authors: C Eric Bailey, Francesca Jung, Benjamin Addicks, Olukemi A Esan, Brian Kellermeyer
Journal: Case Rep Otolaryngol (2017)
MeSH terms: Case Reports

Nodular lymphocyte-predominant Hodgkin lymphoma is an uncommon variant of Hodgkin lymphoma. Progressive transformation of germinal centers has been associated with and can develop prior to, concurrent with, or after the diagnosis of nodular lymphocyte-predominant Hodgkin lymphoma. We present a patient with a history of progressive transformation of germinal centers of the right parotid who presented 4 years later with ipsilateral parotid mass and cervical adenopathy. Knowledge of her previous diagnosis raised our concern for lymphoma, influenced our surgical management, and spared the patient additional surgery with risk of facial nerve injury inherent in revision parotidectomy.
Case report: Hematologic malignancies concomitant diagnosis of hairy cell leukemia and chronic lymphocytic leukemia: A rare association
Authors: Luciana Valvano, Fiorella D'Auria, Vitina Grieco, Teodora Statuto, Filomena Nozza, Giuseppe Pietrantuono, Oreste Villani, Giovanni D'Arena, Daniela Lamorte
Journal: Front Oncol (2022)
Keywords: braf v600e mutation, chronic lymphocytic leukemia, droplet digital pcr, flow cytometry, hairy cell leukemia
MeSH terms: Case Reports

A case of concomitant hairy cell leukemia (HCL) and chronic lymphocytic leukemia (CLL) in a 50- year-old man was reported. Flow cytometry and droplet digital PCR (ddPCR) were used to detect the B-Raf proto-oncogene (BRAF) V600E mutation. The HCL population was the predominant component. The patient was first treated with cladribine and then with rituximab and achieved HCL partial remission. Importantly, the high sensitivity of our flow cytometric approach allowed the detection of a small population "P3," in addition to the typical HCL and CLL clones. The P3 clone changed over time, from an HCL-like to a CLL-like immunophenotype. This case is added to the few other cases of synchronous HCL and CLL already reported in the literature and underlines the importance of analyzing chronic lymphoproliferative disorders by highly sensitive diagnostic techniques, like the multicolor flow cytometry and ddPCR, to evaluate the possible association between HCL and CLL at diagnosis.
Favorable clinical outcome with intravitreal aflibercept treatment in a case with bilateral choroidal neovascular membrane and quiescent Vogt-Koyanagi-Harada syndrome
Authors: Sefik Can Ipek, Ziya Ayhan, Sinan Emre, Ali Osman Saatci
Journal: GMS Ophthalmol Cases (2020)
Keywords: vogt-koyanagi-harada syndrome, aflibercept (862111-32-8), choroidal neovascularization, posterior uveitis
MeSH terms: Case Reports

Objective: To describe the favorable clinical outcome in a case with bilateral choroidal neovascular membrane and quiescent Vogt-Koyanagi-Harada (VKH) syndrome by administering bilateral intravitreal aflibercept injections. Case report: A 30-year-old woman was diagnosed with VKH syndrome at another institution and had been in remission with oral mycophenolate mofetil for two years. However, nearly simultaneous right juxtafoveal and left subfoveal type 2 choroidal neovascular membrane was detected two years after the initial diagnosis. The right eye (OD) received three and the left eye (OS) received four aflibercept injections within a time span of eight months. Visual acuity was 20/30 in OD and 20/25 in OS at the last follow-up visit. Conclusion: Although suppression of inflammation is a must in eyes with inflammatory type choroidal neovascular membranes, anti-VEGF (vascular endothelial growth factor) therapy with agents, such as aflibercept in the present case, is a key therapeutic adjunct and may possibly help improve the visual prognosis.
A Case of a 34-Year-Old Female with Acute Hypoxemic Respiratory Failure and Proximal Muscle Weakness
Authors: Alex Diaz, Surit Sharma
Journal: Case Rep Crit Care (2017)
MeSH terms: Case Reports

Wound associated botulism is an unusual presentation. Early detection of this potentially life-threatening illness can significantly shorten length of hospital stay and improve prognosis. We present a case of a 34-year-old female with a history of heroin abuse who presented to the ED with acute respiratory failure, diplopia, and proximal muscle weakness. There was early concern for wound botulism as the instigating process. After discussion with the CDC, she was given equine serum heptavalent botulism antitoxin. Laboratory analysis later confirmed our suspicion. Symptoms improved and the patient was liberated from mechanical ventilation on day 14 and discharged from the hospital on day 23.
Atypical eclampsia and postpartum status epilepticus
Authors: Zeynep Ozcan Dag, Yuksel Isik, Yakup Turkel, Murat Alpua, Yavuz Simsek
Journal: Pan Afr Med J (2015)
Keywords: eclampsia, preeclampsia, status epilepticus
MeSH terms: Eclampsia / pathology, Puerperal Disorders / diagnosis, Status Epilepticus / diagnosis, Case Reports, Adult, Cesarean Section, Eclampsia / diagnosis, Eclampsia / surgery, Female, Humans, Postpartum Period, Pregnancy, Puerperal Disorders / etiology, Puerperal Disorders / surgery, Status Epilepticus / etiology, Status Epilepticus / surgery

Preeclampsia is an entity that may present from 20th week of gestation up to 48 hours postpartum and is associated with hypertension and proteinuria. Eclampsia is emergence of convulsions pre-eclampsia in pregnant women with signs and symptoms. Recent studies showed that in some women, preeclampsia and even eclampsia may occur without hypertension or proteinuria. Here, we present a case of 26 years old women who had an uneventful pregnancy until 30 weeks' of gestation. She had only proteinuria in laboratory tests and was diagnosed as status epilepticus in early postpartum period. Preeclampsia and eclampsia is related with serious fetal and maternal morbidity and mortality and may present with atypical course. The awareness of atypical cases of preeclampsia enhances early diagnosis and management which are critical to avoid feto-maternal complications.
Wireless Patrol Sign-In System with Mental Fatigue Detection
Authors: Kang-Ming Chang, Hao-Chen Xu, Congo Tak-Shing Ching, Shing-Hong Liu
Journal: J Healthc Eng (2018)
MeSH terms: Mental Fatigue / diagnosis, Wireless Technology, Research Support, Non-U.S. Gov't, Burnout, Professional, Electromyography, Equipment Design, Female, Hand Strength, Humans, Male, Membrane Proteins, Monitoring, Ambulatory, Muscle Strength Dynamometer, Thermometry, Work Schedule Tolerance, Workplace, Young Adult, DynAP protein, human, Membrane Proteins

Current sign-in methods of patrolling security guards mainly comprise signature, image identification, and fingerprint identification; notably, none of these methods indicate the physical and mental conditions of such guards. In particular, when patrolling security guards perform their duties consecutively for a long period of time, adequate attention should be directed toward their levels of mental fatigue. When a handwriting sign-in system is adopted, security guards may not record their sign-in time accurately, or they may fake signatures during long shifts. In addition, image identification systems cannot comprehensively reflect the physical and mental statuses of on-duty security guards, particularly their levels of fatigue. Monitor fatigue in patrolling security guards is important to avoid burnout and stress in the workplace. Therefore, in this study, a patrolling sign-in system that integrates physiological signals and images was designed. A thermometer, hand dynamometer, and electromyography sensor were combined to measure physiological signals. Results showed that hand grip strength and the median frequency of electromyography signals gradually reduced when muscle fatigue occurred. The system determined whether a security guard had signed in punctually and whether this person should stay on duty. Overall, this system was verified to operate effectively, and it is therefore applicable for monitoring the sign-in of patrolling security guards who work long shifts. This case series study proposed a conceptual prototype of the system; large-scale testing should be performed in subsequent research.
The Use of the Model of Occupational Self-Efficacy for Work Retraining: A Multiple Case Study
Authors: Mogammad Shaheed Soeker, Candice Pape
Journal: Occup Ther Int (2019)
MeSH terms: Brain Injuries, Traumatic / rehabilitation, Occupational Therapy / methods, Rehabilitation, Vocational / methods, Return to Work / psychology, Self Efficacy, Adaptation, Psychological, Adult, Brain Injuries, Traumatic / psychology, Female, Humans, Male, Models, Psychological, Occupational Therapy / psychology, Qualitative Research, Rehabilitation, Vocational / psychology

The South African labour law serves as a guide for employers to accommodate injured individuals in the work place. The aim of the study was to explore and describe the experiences of individuals with traumatic brain injury regarding returning to work through the use of the Model of Occupational Self-Efficacy (MOOSE). The study utilized a multiple case study research design, and 10 participants participated in the study. An analytical strategy of explanation building was used to analyse the data. Three themes emerged from the study, i.e., Theme 1: the model has its limitations (barriers), Theme 2: the model helps facilitate work integration (facilitators), and Theme 3: further enhancements to improve the model. The findings of this study indicated that the participant experiences of the MOOSE are a useful model to facilitate the return of individuals living with a TBI back to work. Coping skills and support groups were also viewed as being an important part of the vocational rehabilitation program.
Processing Non-at-Issue Meanings of Conditional Connectives: The wenn/falls Contrast in German
Authors: Mingya Liu
Journal: Front Psychol (2021)
Keywords: german, conditional connectives, experiment, non-at-issue meaning, speaker commitment

Logical connectives in natural language pose challenges to truth-conditional semantics due to pragmatics and gradience in their meaning. This paper reports on a case study of the conditional connectives (CCs) wenn/falls 'if/when, if/in case' in German. Using distributional evidence, I argue that wenn and falls differ in lexical pragmatics: They express different degrees of speaker commitment (i.e., credence) toward the modified antecedent proposition at the non-at-issue dimension. This contrast can be modeled using the speaker commitment scale (Giannakidou and Mari, 2016), i.e., More committed<WENN p, FALLS p>Less committed. Four experiments are reported which tested the wenn/falls contrast, as well as the summary of an additional one from Liu (2019). Experiment 1 tested the naturalness of sentences containing the CCs (wenn or falls) and conditional antecedents with varying degrees of likelihood (very likely/likely/unlikely). The starting prediction was that falls might be degraded in combination with very likely and likely events in comparison to the other conditions, which was not borne out. Experiment 2 used the forced lexical choice paradigm, testing the choice between wenn and falls in the doxastic agent's conditional thought, depending on their belief or disbelief in the antecedent. The finding was that subjects chose falls significantly more often than wenn in the disbelief-context, and vice versa in the belief-context. Experiment 3 tested the naturalness of sentences with CCs and an additional relative clause conveying the speaker's belief or disbelief in the antecedent. An interaction was found: While in the belief-context, wenn was rated more natural than falls, the reverse pattern was found in the disbelief-context. While the results are mixed, the combination of the findings in Experiment 2, Experiment 3 and that of Experiment 4a from Liu (2019) that falls led to lower speaker commitment ratings than wenn, provide evidence for the CC scale. Experiment 4b tested the interaction between two speaker commitment scales, namely, one of connectives (including weil 'because' and wenn/falls) and the other of adverbs (factive vs. non-factive, Liu, 2012). While factive and non-factive adverbs were rated equally natural for the factive causal connective, non-factive adverbs were preferred over factive ones by both CCs, with no difference between wenn and falls. This is discussed together with the result in Liu (2019), where the wenn/falls difference occurred in the absence of negative polarity items (NPIs), but disappeared in the presence of NPIs. This raises further questions on how different speaker commitment scales interact and why.
Case report: Severe deep ulcer on the left abdomen mimicking mycosis fungoides caused by Trichophyton tonsurans in a patient with novel CARD9 mutation
Authors: Jingwen Tan, Qian Yu, Zhiqin Gao, Hong Yang, Qilong Chen, Lianjuan Yang
Journal: Front Immunol (2022)
Keywords: trichophyton tonsurans, deep dermatophytosis, novel card9 mutation, posaconazole, tinea corporis
MeSH terms: Arthrodermataceae, Mycosis Fungoides / diagnosis, Mycosis Fungoides / drug therapy, Mycosis Fungoides / genetics, Skin Neoplasms / diagnosis, Skin Neoplasms / drug therapy, Skin Neoplasms / genetics, Tinea / diagnosis, Tinea / drug therapy, Tinea / microbiology, Case Reports, Research Support, Non-U.S. Gov't, Abdomen, Antifungal Agents / therapeutic use, CARD Signaling Adaptor Proteins / genetics, Humans, Mutation, Ulcer, Antifungal Agents, CARD Signaling Adaptor Proteins, CARD9 protein, human, Trichophyton tonsurans

Dermatophytosis is the most common type of superficial fungal infection caused by dermatophytes. Occasionally, the fungus invades deep into the dermis or other tissues, causing deep dermatophytosis. Deep dermatophytosis is often associated with Caspase Recruitment Domain-containing protein 9 (CARD9) deficiency in patients. Here, we report the first case of deep dermatophytosis with a rare mycosis fungoides manifestation caused by T. tonsurans in a patient with a novel mutation in exon 4 of CARD9. The condition presented with heterozygous K196E mutation, which leads to deficiency of innate and adaptive immune responses in the patient, and caused intractable severe lesions. The patient received treatment with multiple antifungal drugs and was ultimately alleviated by posaconazole. These findings extend the pathogen spectrum of deep dermatophytosis linked with CARD9 deficiency and enriched their phenotypic spectrum.
Spontaneous symptomatic pseudoarthrosis at the l2-l3 intervertebral space with diffuse idiopathic skeletal hyperostosis: a case report
Authors: Keiji Hasegawa, Hiroshi Takahashi, Yasuaki Iida, Yuichirou Yokoyama, Katsunori Fukutake, Ryo Takamatsu, Kazumasa Nakamura, Daisuke Suzuki, Wataru Shishikura, Shintaro Tsuge, Masayuki Sekiguchi, Akihito Wada
Journal: Case Rep Orthop (2013)

Pseudoarthrosis at the intervertebral space in patients with ankylosing spondylitis has occasionally been reported, but symptomatic pseudoarthrosis at the intervertebral disc level is rare in patients with diffuse idiopathic skeletal hyperostosis (DISH). Here, we report a case of symptomatic pseudoarthrosis at the L2-L3 intervertebral space that was diagnosed based on clinical history. We first performed L1-L5 fixation, but back-out of the pedicle screw occurred in the early postoperative phase and may have been caused by a short fixation range and concomitant Parkinson's disease. However, the prognosis of the case was favorable after a second surgery. This case indicates that a fixation range of at least 3 above and 3 below is necessary for bone fracture of a thoracolumbar vertebra and pseudoarthrosis in patients with DISH.
Exploring impacts of multi-year, community-based care programs for orphans and vulnerable children: a case study from Kenya
Authors: Bruce A Larson, Nancy Wambua, Juliana Masila, Susan Wangai, Julia Rohr, Mohamad Brooks, Malcolm Bryant
Journal: AIDS Care (2013)
MeSH terms: Caregivers / economics, Child Welfare, Child, Orphaned, Community Networks / economics, Financing, Organized, Vulnerable Populations, Adolescent, Adult, Child, Child, Preschool, Cross-Sectional Studies, Educational Status, Family Characteristics, Female, Food Supply, Humans, Income / statistics & numerical data, Kenya, Middle Aged, Organizational Case Studies, Program Evaluation / methods, Residence Characteristics, Retrospective Studies, Time Factors, Young Adult

The Community-Based Care for Orphans and Vulnerable Children (CBCO) program operated in Kenya during 2006-2010. In Eastern Province, the program provided support to approximately 3000 orphans and vulnerable children (OVC) living in 1500 households. A primary focus of the program was to support savings and loan associations composed of OVC caregivers (typically elderly women) to improve household and OVC welfare. Cross-sectional data were collected in 2011 from 1500 randomly selected households from 3 populations: program participants (CBCO group, n=500), households in the same villages as program participants but not in the program (the local-community-group = Group L, n=300), and households living in nearby villages where the program did not operate (the adjacent-community-group, Group A, n=700). Primary welfare outcomes evaluated are household food security, as measured by the Household Food Insecurity Access instrument, and OVC educational attainment. We compared outcomes between the CBCO and the subset of Group L not meeting program eligibility criteria (L-N) to investigate disparities within local communities. We compared outcomes between the CBCO group and the subset of Group A meeting eligibility criteria (A-E) to consider program impact. We compared outcomes between households not eligible for the program in the local and adjacent community groups (L-N and A-N) to consider if the adjacent communities are similar to the local communities. In May-June 2011, at the end of the OVC program, the majority of CBCO households continued to be severely food insecure, with rates similar to other households living in nearby communities. Participation rates in primary school are high, reflecting free primary education. Among the 18-22 year olds who were "children" during the program years, relatively few children completed secondary school across all study groups. Although the CBCO program likely provided useful services and benefits to program participants, disparities continued to exist in food security and educational outcomes between program participants and their non-OVC peers in the local community. Outcomes for CBCO households were similar to those observed for OVC households in adjacent communities.
A Case of a 4-Year-Old Boy with a Mesenteric Chylous Cyst Infected with Histoplasma capsulatum
Authors: Vianney Kweyamba, Mirraim Apiyo, Biratu Olika, Olivia Kituuka
Journal: Case Rep Surg (2016)

Mesenteric cysts are uncommon entities and chyle- (lymph-) containing cysts are the rarest of this group. This is a case report of a 4-year-old boy with a mesenteric chylous cyst who was later found to have Histoplasma capsulatum infection.
Case Report: Sars-CoV-2 Infection in a Vaccinated Individual: Evaluation of the Immunological Profile and Virus Transmission Risk
Authors: Claudia Strafella, Valerio Caputo, Gisella Guerrera, Andrea Termine, Carlo Fabrizio, Raffaella Cascella, Mario Picozza, Carlo Caltagirone, Angelo Rossini, Maria Pia Balice, Antonino Salvia, Luca Battistini, Giovanna Borsellino, Emiliano Giardina
Journal: Front Immunol (2021)
Keywords: covid19, sars-cov-2 infection, immune response, immunology, vaccination
MeSH terms: B-Lymphocytes / immunology, COVID-19 / immunology, COVID-19 Vaccines / immunology, Health Personnel, SARS-CoV-2 / physiology, T-Lymphocytes / immunology, Case Reports, Research Support, Non-U.S. Gov't, Adult, Asymptomatic Diseases, BNT162 Vaccine, COVID-19 / diagnosis, COVID-19 / prevention & control, COVID-19 / transmission, Disease Transmission, Infectious, Female, Humans, Immunity, Humoral, Italy, RNA, Viral / analysis, Risk, Vaccination, Viral Load, COVID-19 Vaccines, RNA, Viral, BNT162 Vaccine, COVID-19 breakthrough infections

During the COVID19 pandemic, a range of vaccines displayed high efficacy in preventing disease, severe outcomes of infection, and mortality. However, the immunological correlates of protection, the duration of immune response, the transmission risk over time from vaccinated individuals are currently under active investigation. In this brief report, we describe the case of a vaccinated Healthcare Professional infected with a variant of Sars-CoV-2, who has been extensively investigated in order to draw a complete trajectory of infection. The patient has been monitored for the whole length of infection, assessing the temporal viral load decay, the quantification of viral RNA and subgenomic mRNA, antibodies (anti Sars-CoV-2, IgA, IgG, IgM) and cell-mediated (cytokine, B- and T-cell profiles) responses. Overall, this brief report highlights the efficacy of vaccine in preventing COVID19 disease, accelerating the recovery from infection, reducing the transmission risk, although the use of precautionary measures against Sars-CoV-2 spreading still remain critical.
Congenital Glaucoma: a Novel Ocular Manifestation of Hajdu-Cheney Syndrome
Authors: L Swan, G Gole, V Sabesan, J Cardinal, D Coman
Journal: Case Rep Genet (2018)
MeSH terms: Case Reports

Hajdu-Cheney Syndrome (HSC) is a rare multisystem disease in which the phenotype involves acro-osteolysis, severe osteoporosis, short stature, wormian bones, facial dysmorphism, central neurological abnormalities, cardiovascular defects, and polycystic kidneys. We describe an infant with severe manifestations of HCS in whom congenital glaucoma was a significant early feature, which has not been reported to date. HCS cases reported to date have involved truncating mutations in exon 34 of NOTCH2 upstream the PEST domain that lead to the development of a truncated and stable NOTCH2 protein which upregluates notch signaling. We describe a hitherto undescribed missense mutation that is predicted to be pathogenic, with functional characterization remaining to be performed. Serpentine fibula-polycystic kidney syndrome (SFPKS) is allelic to HCS and commonly associated with missense NOTCH2 mutations. Our patient provides new ophthalmological manifestations of HCS and provides insight into the potential role of notch signaling in the anterior chamber development.
Giant popliteal artery aneurysm: case report and review of the literature
Authors: Christos Verikokos, Georgios Karaolanis, Mikes Doulaptsis, Georgios Kouvelos, Aikaterini Kotzadimitriou, Viktoria-Varvara Palla, Christos Klonaris
Journal: Case Rep Vasc Med (2014)

Popliteal artery aneurysms (PAAs) are rare in general population but represent the second most common peripheral arterial aneurysms following those located in the aortoiliac segment. They usually affect men over 60 years old with established cardiovascular disease caused by atherosclerosis. Other more unusual conditions such as trauma, congenital popliteal aneurysm, mycotic aneurysm, inflammatory arteritis, or popliteal entrapment are responsible. The authors report the first ever case of a male diagnosed with chronic renal failure with giant popliteal artery aneurysm. We have successfully resected the aneurysm and revascularized with synthetic graft.