OpenMed/multicare-articles huggingface dataset:
Severe Refractory Paraneoplastic Mucous Membrane Pemphigoid Successfully Treated With Rituximab
Authors: Marcel Wittenberg, Margitta Worm
Journal: Front Med (Lausanne) (2019)
Keywords: laminin 332, mucous membrane pemphigoid, paraneoplastic, rituxmab, therapy refractoriness
MeSH terms: Case Reports

Mucous membrane pemphigoid (MMP) is a rare autoimmune bullous disease of the mucous membranes, which can cause irreversible scarring and is discussed to be associated with cancer, if laminin-332-autoantibodies are present. MMP with severe ocular and laryngeal involvement is difficult to treat and can be treatment-refractory to conventional immunosuppressant therapy. A 67-year-old man with a history of prostate cancer presented to our clinic with sore throat, intraoral bullae, odynophagia, dysphonia, exertional dyspnea, and erosions of the glans penis. Clinical examination confirmed a laryngo-pharyngitis with involvement of the epiglottis and bilateral symblepharon. Diagnostics comprising multiple biopsies, direct and indirect immunofluorescence, serology analysis, and immunoblotting confirmed the diagnosis of a paraneoplastic MMP by showing a subepithelial split in histology and the presence of anti-laminin-332-antibodies. Despite combined systemic treatment with prednisolone and either dapsone or azathioprine, a progress of the disease occurred leading to severe ocular and laryngeal complications. Two month after rituximab treatment, complete disease control was achieved. This case report shows a severe ocular and life threatening laryngeal involvement of therapy-refractory paraneoplastic MMP highlighting the importance of interdisciplinary management and difficulty of diagnosing MMP despite repeated diagnostic testing.
A rare cause of sciatica: Sciatic nerve schwannoma - Report of one case with long subclinical course and misleading presentation
Authors: Renaud Maes, Pascal Ledoux, Grégoire de Brouckere
Journal: SICOT J (2020)
Keywords: schwannoma, sciatic nerve
MeSH terms: Case Reports

The authors report one case of schwannoma located in the sciatic nerve, just above the popliteal fossa. A sciatic localization is rare, observed in 1% of the patients. The misleading clinical presentation of this localization causes a delay in diagnosis. Magnetic Resonance Imaging (MRI) is the imaging modality of choice, but the final diagnosis is made by the histological examination of the tumor. Schwannoma should be surgically removed without division of the nerve trunk.
Case report: Mechanical thrombectomy for acute basilar artery occlusion via persistent hypoglossal artery
Authors: Xin Zhang, Jiaxiong Wang, Zhipeng Cao, Yingtao Liu, Yi Dong, Xin Cheng, Chao Gao, Yuxiang Gu
Journal: Front Neurol (2023)
Keywords: acute ischemic stroke, basilar artery occlusion, case report, persistent hypoglossal artery, thrombectomy
MeSH terms: Case Reports

Persistent hypoglossal artery (PHA) is a rare carotid-vertebrobasilar anastomosis in adults. Here, we report a case of mechanical thrombectomy for acute basilar artery occlusion via the PHA. A 44-year-old man was admitted to our stroke unit with an unstable gait and aphasia for 2 h. The baseline National Institutes of Health Stroke Scale (NIHSS) score was 4, but the clinical symptoms continued to worsen. Computed tomography angiography showed the absence of the basilar artery and an abnormal anastomosis between the anterior and posterior circulation. Clinical symptoms continued to worsen, and endovascular treatment was scheduled. PHA was demonstrated and basilar artery occlusion was confirmed using digital subtraction angiography. Mechanical thrombectomy with a stent retriever and aspiration was performed via the PHA, and modified thrombolysis in cerebral infarction level 3 was achieved. The patient underwent intravenous antiplatelet therapy after the operation, and follow-up neuroimaging revealed multiple small infarcts in the cerebellum and medulla oblongata. The patient was discharged after 10 days for further rehabilitation, with an NIHSS score of 25. At 10 months follow-up, the NIHSS score decreased to 18. Recognition of this rare variation is particularly important for interventional strategy determination and rapid recanalization of basilar artery occlusion.
Case Report: Pityriasis Rosea-Like Eruption Following COVID-19 Vaccination
Authors: Kanchana Leerunyakul, Kallapan Pakornphadungsit, Poonkiat Suchonwanit
Journal: Front Med (Lausanne) (2021)
Keywords: sars-cov-2, adverse effect, case report, coronavirus, cutaneous eruptions, immunization, pityriasis rosea, vaccine
MeSH terms: Case Reports

Vaccination is one of the cornerstones in the efforts towards ending the coronavirus disease 2019 (COVID-19) pandemic. However, several adverse effects of COVID-19 vaccination have been identified. Pityriasis rosea (PR)-like eruption is a rare cutaneous complication of immunization. To the best of our knowledge, there have been no reports of PR-like eruptions following inoculation with Oxford/AstraZeneca ChAdOx1 nCoV-19 (AZD1222) vaccine. Here, we described a case of PR-like eruption that developed 14 days after Oxford/AstraZeneca vaccination in a 52-year-old Thai woman with glioblastoma. Treatment with topical 0.1% triamcinolone acetonide twice per day showed partial response after seven days. Despite this rare complication, our report highlights that the presence of PR-like eruption is not a contraindication for subsequent vaccinations.
Pectoralis Minor Syndrome: Case Presentation and Review of the Literature
Authors: Mohammed Abdallah, Mohammad Rachad Wehbe, Elias Elias, Muhammad Aghiad Kutoubi, Roger Sfeir
Journal: Case Rep Surg (2016)

We present a case of a healthy young female with axillary vein compression caused by the pectoralis minor muscle. Diagnosis was made by clinical findings and dynamic venography. After pectoralis minor tenotomy, the patient had total resolution of her symptoms. Compression of the axillary vein by the pectoralis minor is a rare entity that needs a careful exam and imaging to reach its diagnosis and establish the appropriate treatment.
Resection of liposarcoma of the greater omentum: A case report and literature review
Authors: Shintaro Hashimoto, Junichi Arai, Masato Nishimuta, Hirofumi Matsumoto, Hidetoshi Fukuoka, Masashi Muraoka, Masahiro Nakashima, Hiroyuki Yamaguchi
Journal: Int J Surg Case Rep (2019)
Keywords: liposarcoma, omental liposarcoma, omental tumour

Introduction:
Liposarcoma usually occurs in the retroperitoneum and limbs. Liposarcoma of the greater omentum is rare, and most information of such liposarcomas has come from case reports.
Presentation of case:
A 60-year-old woman was found to have an 8-cm intra-abdominal mass (suspected lipoma) by computed tomography. At the age of 63 years, she underwent a medical examination and a mass was palpated in the abdomen. Contrast-enhanced computed tomography and magnetic resonance imaging confirmed the presence of a huge intra-abdominal tumor with the omental artery passing through the mass. The tumor was simply resected. Histopathologically, the tumor was diagnosed as a well-differentiated liposarcoma, and the resection margin was microscopically negative. The patient had developed no recurrence or complications 9 months postoperatively.
Discussion:
Liposarcoma of the greater omentum is rare, and differentiation of liposarcoma from other tumors is challenging. Adjuvant therapy has not been established as an effective treatment, and radical (R0) resection of the tumor is recommended. Our case of liposarcoma of the greater omentum was surgically managed with good outcomes.
Conclusion:
The diagnosis of liposarcoma with a lipomatous tumor is challenging, and resection should be considered for huge intra-abdominal lipomatous tumors.
Fibrolipoma of the Buccal Mucosa: A Case Report and Review of the Literature
Authors: Masayasu Iwase, Naotaka Saida, Yoko Tanaka
Journal: Case Rep Pathol (2016)

Lipomas are common benign soft tissue neoplasms derived from mature adipose tissue. However, they rarely arise in the oral cavity. Fibrolipoma is a histological variant of lipoma that mainly affects the buccal mucosa and causes functional and cosmetic issues. This article describes the case of a 71-year-old male with a fibrolipoma of the left buccal mucosa and a review of previous articles about fibrolipoma.
Chemotherapy-induced cavitating Wilms' tumor pulmonary metastasis: Active disease or scarring? A case report and literature review
Authors: Angelo Zarfati, Cristina Martucci, Alessandro Crocoli, Annalisa Serra, Giorgio Persano, Alessandro Inserra
Journal: Front Pediatr (2023)
Keywords: wilms’ tumor, atypical metastasis, cavitation, chemotherapy, computed-tomography, lung metastasis, nephroblastoma, pulmonary metastasis
MeSH terms: Case Reports

The second most common abdominal tumor in children is Wilms' tumor, and the lung is where it most often metastasizes. The typical metastases are multiple, peripherally located, round, and variable-sized nodules. Atypical patterns are also possible and may create diagnostic challenges, especially in patients treated with chemotherapy. Among these, cavitating metastases are an anecdotal type of atypical secondary lung lesions. Here, we report a case of a chemotherapy-induced cavitating Wilms' tumor pulmonary metastasis discovered during the follow-up for an anaplastic nephroblastoma in a 6-year-old girl. Furthermore, we conducted a review of the existing literature on this exceedingly rare radiological pattern to establish its best management.
Plexiform Schwannoma of the Tongue in a Pediatric Patient with Neurofibromatosis Type 2: A Case Report and Review of Literature
Authors: Samir M Amer, Aijan Ukudeyeva, Harold S Pine, Gerald A Campbell, Cecilia G Clement
Journal: Case Rep Pathol (2018)
MeSH terms: Case Reports

Introduction:
Plexiform schwannoma is a rare variant of schwannoma that accounts for only 5% of all schwannomas. Herein, we present a rare case of plexiform schwannoma of the tongue in a pediatric patient with neurofibromatosis type 2 (NF2).
Case presentation:
A 13-year-old female presented with a growing left-sided tongue mass. The patient has a past medical history of NF2. The tongue mass was excised and histopathological examination revealed a spindle cell tumor with multinodular growth pattern, with Verocay bodies' formation. Tumor cells were strongly positive for S-100 protein and negative for smooth muscle actin (SMA), and EMA highlighted perineural fibroblasts surrounding tumor nodules. These findings were diagnostic of plexiform schwannoma.
Conclusion:
Plexiform schwannoma of the tongue is an extremely rare tumor seen in patients with NF2. Clinical examination and histopathological evaluation are important for diagnosis of plexiform schwannoma.
Recurrence of pancreatic cancer presented as cervical lymphadenopathy
Authors: Hiroshi Nagata, Ken Hayashi, Shigetoshi Yamada
Journal: World J Surg Oncol (2016)
MeSH terms: Adenocarcinoma / secondary, Pancreatic Neoplasms / pathology, Case Reports, Adenocarcinoma / diagnosis, Adenocarcinoma / therapy, Aged, Chemoradiotherapy, Adjuvant, Female, Humans, Lymphatic Metastasis, Neck, Pancreatic Neoplasms / therapy, Pancreaticoduodenectomy

Background:
We report a case of recurrent pancreatic cancer that presented as cervical lymphadenopathy.
Case presentation:
A 69-year-old woman with stage IIb pancreatic cancer underwent a curative Whipple's procedure after neoadjuvant chemoradiation therapy. Despite adjuvant chemotherapy with S-1, postoperative recurrence was diagnosed as left cervical lymphadenopathy 11 months postoperatively. After she underwent chemoradiation therapy to the cervical area followed by systemic chemotherapy with S-1, the lymphadenopathy became unremarkable 17 months postoperatively. S-1 treatment was discontinued 23 months postoperatively at the patient's request. She has remained free of disease since that time and has achieved an overall duration of survival of 48 months.
Conclusions:
To the best of our knowledge, this is the first reported case of middle cervical lymph node metastasis of pancreatic cancer. Although rare, it should be considered as a site of recurrence. This case suggests concurrent radiation therapy can be a good option for patients who cannot tolerate an aggressive regimen.
Treatment of Aggressive Pituitary Adenomas: A Case-Based Narrative Review
Authors: Odelia Cooper, Vivien Bonert, Ning-Ai Liu, Adam N Mamelak
Journal: Front Endocrinol (Lausanne) (2021)
Keywords: aggressive adenomas, pituitary adenomas, radiation therapy, surgery, targeted therapy, temozolomide
MeSH terms: Adenoma / therapy, Pituitary Neoplasms / therapy, Case Reports, Review, Adenoma / pathology, Adolescent, Adult, Child, Combined Modality Therapy, Female, Humans, Male, Pituitary Neoplasms / pathology, Prognosis, Young Adult

Management of aggressive pituitary adenomas is challenging due to a paucity of rigorous evidence supporting available treatment approaches. Recent guidelines emphasize the need to maximize standard therapies as well as the use of temozolomide and radiation therapy to treat disease recurrence. However, often these adenomas continue to progress over time, necessitating the use of additional targeted therapies which also impact quality of life and long-term outcomes. In this review, we present 9 cases of aggressive pituitary adenomas to illustrate the importance of a multidisciplinary, individualized approach. The timing and rationale for surgery, radiation therapy, temozolomide, somatostatin receptor ligands, and EGFR, VEGF, and mTOR inhibitors in each case are discussed within the context of evidence-based guidelines and clarify strategies for implementing an individualized approach in the management of these difficult-to-treat-adenomas.
Hallux Osteoid Osteoma: A Case Report and Literature Review
Authors: Konstantinos C Xarchas, George Kyriakopoulos, Spyros Manthas, Leon Oikonomou
Journal: Open Orthop J (2017)
Keywords: benign, foot, hallux, osteoid osteoma, treatment, tumours
MeSH terms: Review

Osteoid osteoma is a benign bone tumour that mostly affects males in the second and third decade of their life. The lesion mainly occurs in long bones, usually in the femur and tibia, causing severe localized pain that is worse at night and responds to nonsteroidal anti-inflammatory drugs (NSAIDs). Diagnosis is usually made on the basis of history and radiographic findings. However, in more unusual locations as the hand and foot, diagnostic issues can arise. Treatment often includes complete removal of the tumor. We present a 22 year old male with osteoid osteoma involving the distal phalanx of the hallux. To our knowledge very few cases of great toe osteoid osteoma have been reported in the literature.
Case Report: Convalescent Plasma Achieves SARS-CoV-2 Viral Clearance in a Patient With Persistently High Viral Replication Over 8 Weeks Due to Severe Combined Immunodeficiency (SCID) and Graft Failure
Authors: Verena Keitel, Johannes Georg Bode, Torsten Feldt, Andreas Walker, Lisa Müller, Anselm Kunstein, Caroline Klindt, Alexander Killer, Tina Senff, Jörg Timm, Philipp Ostermann, Maximilian Damagnez, Nadine Lübke, Ortwin Adams, Heiner Schaal, Gerald Antoch, Jennifer Neubert, Philipp Albrecht, Sven Meuth, Saskia Elben, Annemarie Mohring, Johannes C Fischer, Edwin Bölke, Manfred Hoenig, Ansgar S Schulz, Tom Luedde, Björn Jensen
Journal: Front Immunol (2021)
Keywords: sars-cov-2, convalescent plasma, humoral immune response, remdesivir, severe combined immunodeficiency
MeSH terms: COVID-19 / therapy, SARS-CoV-2 / physiology, Severe Combined Immunodeficiency / complications, Case Reports, Adult, Antibodies, Viral / blood, COVID-19 / complications, COVID-19 / immunology, COVID-19 / virology, COVID-19 Serotherapy, Female, Graft Rejection / complications, Graft Rejection / immunology, Graft Rejection / virology, Humans, Immunization, Passive, Severe Combined Immunodeficiency / immunology, Severe Combined Immunodeficiency / virology, Sustained Virologic Response, Viral Load, Virus Replication, Antibodies, Viral

We describe the unique disease course and cure of SARS-CoV-2 infection in a patient with SCID and graft failure. In absence of a humoral immune response, viral clearance was only achieved after transfusion of convalescent plasma. This observation underscores the necessity of the humoral immune response for SARS-CoV-2 clearance.
Case Report: Concomitant coronary stent and femoral artery thrombosis in the setting of heparin-induced thrombocytopenia
Authors: Mejdi Ben Messaoud, Mezri Maatouk, Mohamed Mehdi Boussaada, Marouane Mahjoub, Walid Mnari, Habib Gamra
Journal: F1000Res (2019)
Keywords: key words
MeSH terms: Thrombocytopenia, Thrombosis, Case Reports, Aged, Femoral Artery, Heparin, Humans, Male, Stents, Stroke Volume, Ventricular Function, Left, Heparin

Heparin induced thrombocytopenia (HIT) is a rare but potentially life threatening adverse drug reaction. We report an unusual case of concomitant subacute coronary stent and femoral artery thrombosis secondary to HIT. In the current era of extensive growth of heparin use and percutaneous coronary interventions, it's important for clinicians to remember that such complication might occur and should be prevented.
Case report: Resolution of oligo-anuric acute kidney injury with furosemide administration in a cat following lily toxicity
Authors: An To, Claudia Davila, Sarah Stroope, Rebecca Walton
Journal: Front Vet Sci (2023)
Keywords: acute kidney injury, anuria, furosemide, lily (lilium and hemerocallis spp), oligo-anuria, toxicity
MeSH terms: Case Reports

Objective:
To describe the successful outcome of a case of oligo-anuric acute kidney injury in a cat secondary to lily ingestion.
Case summary:
A 12-week-old intact male domestic short-hair cat weighing 1.64 kg (3.6 lb) presented with a 12-h duration of vomiting and lethargy after exposure to lilies of the genera Lilium species 24 h prior to presentation. Severe azotemia (Creatinine 5.8 mg/dL, BUN > 100 mg/dL) and hyperkalemia (9.36 mmol/L) were noted on the day of presentation. Treatment of hyperkalemia was instituted with calcium gluconate, lactated ringers solution, dextrose, regular short-acting insulin, albuterol, and sodium bicarbonate, Oliguria to anuria was highly suspected based on a lack of urine production 21 h after hospitalization with intravenous fluid administration and a static bladder size. The cat was administered 4 mg/kg of furosemide, and urinated at 6 h following administration and continued to produce over 6 ml/kg/h of urine in the next 24 h. Two days following furosemide administration, the cat's hyperkalemia and azotemia resolved. The cat was discharged after 4 days of hospitalization, and a recheck revealed no persistent azotemia or hyperkalemia.
Unique information:
Anuric acute kidney injury secondary to lily toxicity is associated with a poor prognosis, and the only treatment modality previously described is hemodialysis. The cat in this report was successfully managed with medical intervention and furosemide administration, with complete resolution of the acute kidney injury.
A novel variant of genotype 7b hepatitis C virus emphasizing viral hepatitis elimination challenges for sub-Saharan Africa
Authors: Mark Wayne Sonderup, Heidi Smuts, Catherine Wendy Spearman
Journal: Pan Afr Med J (2020)
Keywords: hepatitis c, elimination programmes, genotype diversity
MeSH terms: Antiviral Agents / administration & dosage, Hepacivirus / genetics, Hepatitis C, Chronic / diagnosis, Case Reports, Africa South of the Sahara, Aged, Drug Resistance, Viral, Female, Genotype, Hepatitis C, Chronic / drug therapy, Hepatitis C, Chronic / virology, Humans, Antiviral Agents

Sub-Saharan Africa has approximately 10.15 million people viraemic with chronic hepatitis C virus infection, extensive genotype and sub-genotype diversity is present, in addition to novel hepatitis C genotypes. Many of the unusual genotypes have extensive baseline resistance associated substitutions with direct acting antiviral therapy treatment outcome data, limited. We report a patient found to have a novel genotype 7b variant with extensive baseline resistance associated substitutions. There is a clear need for a better understanding of the virological characteristics of hepatitis C populations in sub-Saharan Africa to guide best optimal treatment decisions in national hepatitis C elimination programmes.
Melioidosis in Bihar, India: unearthing the first of many?
Authors: Isra Halim, Prathyusha Kokkayil, Ravi Kirti, Rajeev Nayan Priyadarshi, Asim Sarfraz, Binod Kumar Pati, Bhaskar Thakuria
Journal: Access Microbiol (2021)
Keywords: burkholderia pseudomallei, disseminated melioidosis, melioidosis
MeSH terms: Case Reports

Melioidosis, a disease with protean clinical manifestations, is prevalent in many parts of India, with established endemic hotspots on the southern coast of the country. However, it is still underdiagnosed in many resource-poor regions of the country. We report what is, to the best of our knowledge, the first case of melioidosis diagnosed and treated in Bihar, an economically underdeveloped state in East India. The patient, a 52-year-old diabetic male, presented to the outpatient department with a fever of insidious onset along with pain and restriction of movement in the right shoulder joint and right knee joint, and swelling and tenderness of bilateral ankle joints. Radiological features were suggestive of multiple joint and organ abscesses. A diagnosis of disseminated septicaemic melioidosis was confirmed microbiologically. The patient improved clinically following aggressive treatment with meropenem and cotrimoxazole. The case highlights the need for increased clinical suspicion of melioidosis and adequate diagnostic facilities, as well as the need for early institution of appropriate empirical antibiotics in suspected cases of melioidosis in this region of the world.
Hybrid surgery for coexistence of cerebral arteriovenous malformation and primitive trigeminal artery: A case report and literature review
Authors: Lesheng Wang, Jieli Li, Zhengwei Li, Songshan Chai, Jincao Chen, Nanxiang Xiong, Bangkun Yang
Journal: Front Surg (2022)
Keywords: case report, cerebral arteriovenous malformation, hybrid surgery, literature review, primitive trigeminal artery
MeSH terms: Case Reports

The primitive trigeminal artery (PTA), an abnormal carotid-basilar anastomosis, forms the vascular anomaly connection between the internal carotid artery and vertebrobasilar system. Rarely, PTA can be complicated by several other cerebrovascular disease, including arteriovenous malformations (AVMs), intracranial aneurysms, moyamoya disease, and carotid-cavernous malformations. Herein, we reported a rare case of PTA combined with an AVM in a male patient. The patient was a 28-year-old male with epileptic seizures at the onset of symptoms. Magnetic resonance imaging showed abnormal signal foci and localized softening foci formation with gliosis in the right parietal temporal lobe. Furthermore, using a digital subtraction angiogram (DSA), it was found that an abnormal carotid-basilar anastomosis had developed through a PTA originating from the cavernous portion of the right internal carotid artery (ICA) and a large AVM on the surface of the right carotid artery. The lesion of AVM tightly developed and draining into superior sagittal sinus. A hybrid operating room was used for the surgery. The main feeding arteries of the AVM originating from three major arteries, including the right middle cerebral artery, the right anterior cerebral artery, and the right posterior cerebral artery, were clipped and subsequently, then the AVM was thoroughly removed. The intraoperative DSA showed that the AVM had been resected completely. Postoperative pathological examination of the resected specimen indicated the presence of an AVM. The patient recovered well after surgery and has been symptom-free for more than 3 months. In summary, the pathogenesis of the coexistence of PTA and AVM remains unknown. As highlighted in this case report, hybrid surgery can be used to remove AVMs and can improve the patients' prognosis. To our best knowledge, this is the first case in the literature of successful AVM treatment using hybrid surgery.