OpenMed/multicare-articles huggingface dataset:
Arteriovenous fistula as a complication of transradial coronary angiography: a case report
Authors: Payam Dehghani, Jennifer Culig, Darshan Patel, Greg Kraushaar, Paul Schulte
Journal: J Med Case Rep (2013)

Introduction:
Iatrogenic arteriovenous fistula is a vascular condition that may result from coronary angiography. Many case reports have described arteriovenous fistula occurrence after coronary angiography using the transfemoral access route, but rarely as a complication of using the transradial approach. We report a rare case of a patient with arteriovenous fistula following transradial artery coronary angiography.
Case presentation:
A 62-year-old Caucasian man underwent emergent coronary angiography using the right radial artery approach. One month after angiography, he discovered a turbulent sound near the access site. A right radial arteriovenous fistula was found upon duplex ultrasound investigation. The patient was treated conservatively. At 1-year follow-up, the arteriovenous fistula was unchanged and the patient remained hemodynamically stable and asymptomatic.
Conclusion:
Iatrogenic arteriovenous fistula is a rare vascular complication of transradial artery coronary angiography. The natural history of arteriovenous fistula is benign and is thought to resolve spontaneously; therefore, a conservative approach, as opposed to surgical ligation, is recommended as the first-line treatment.
A Case of Aspiration Pneumonia Caused by Cerebrospinal Fluid Leaks Associated with Delayed Identification of Iatrogenic Skull Base Injury during Endoscopic Sinus Surgery
Authors: Takashi Anzai, Akira Baba, Shin Ito, Yo Suzuki, Shori Tajima, Satoshi Hara, Yusuke Takata, Fumihiko Matsumoto, Katsuhisa Ikeda
Journal: Case Rep Otolaryngol (2021)
MeSH terms: Case Reports

Cerebrospinal fluid (CSF) leaks associated with endoscopic sinus surgery (ESS) are a rare complication affecting approximately 0.09% of patients. Although meningitis is a well-known complication of CSF leaks, the case we present is a rare and cautionary case of CSF leakage associated with ESS leading to aspiration pneumonia. A 43-year-old man with CSF leaks after ESS was referred to our hospital. After the operation, sometimes, he reported having a serous nasal discharge from the right side when he bent over, and he woke up choking on something every day. He also experienced headache, fever, fatigue, and cough. Interestingly, chest computed tomography (CT) showed a consolidation and ground-glass opacity in the posterior segments of the right upper lobes and superior segments of the bilateral lower lobes. These CT imaging findings were similar to those of aspiration pneumonia in bedridden patients who are always in a supine position. These findings suggest that CSF caused aspiration pneumonia. To the best of our knowledge, no case of aspiration pneumonia caused by CSF during endoscopic sinus surgery has been reported until now. If a patient with CSF leakage after ESS experiences fever, cough, or fatigue, physicians should consider aspiration pneumonia in addition to meningitis.
Paraesophageal hernia repair with bifacial mesh
Authors: S Ungureanu, N Șipitco, N Gladun, C Lepadatu
Journal: J Med Life (2016)
Keywords: hiatus hernia, paraesophageal hernia, surgical mesh, type ii hiatus hernia
MeSH terms: Hernia, Hiatal / surgery, Herniorrhaphy / methods, Surgical Mesh, Case Reports, Editorial, Humans, Laparoscopy, Male, Middle Aged

Background.The paraesophageal hiatus hernias (PHH) are relatively uncommon, but an increased incidence has been reported and they now account for 5-10% of all hiatus hernias. The surgical treatment is recommended for all the patients with this pathology because of high risk of complications: obstruction, incarceration, strangulation or perforation. The use of prostheses is recommended in the process of repairing the giant PHH because the main problem of this operation is the high rate of recurrence. Case presentation.The patient is a 44-year-old male with a large and symptomatic paraesophageal hernia. Diagnosis was confirmed by instrumental examination. An elective laparoscopic repair was carried out by using polypropylene bifacial anti adhesive synthetic mesh (Surgimesh XB Aspide Medical). The postoperative period passed without severe complications. Conclusions.The laparoscopic approach as a therapeutic option can be successfully used in the repair of paraesophageal hernia. A selective use based on clinical experience was recommended, as the technique appeared to be safe, and in case of large hiatus hernia with hiatal defect, greater than 5 cm, the application of synthetic material to minimize the recurrence rate was recommended.
Severe early-onset manifestations of generalized arterial calcification of infancy (mimicking severe coarctation of the aorta) with ABCC6 gene variant - Case report and literature review
Authors: Amalia Fãgãrãşan, Liliana Gozar, Simina-Elena Rusu Ghiragosian, Mircea Murariu, Marian Pop, Andrei Crauciuc, Diana Miclea, Carmen Corina Şuteu
Journal: Front Cardiovasc Med (2022)
Keywords: abcc6 gene, gaci, infant, infantile heart failure, systemic hypertension
MeSH terms: Case Reports

Introduction:
Generalized arterial calcification of infancy (GACI) is a rare cause of infantile heart failure and systemic hypertension with a poor prognosis, characterized by extensive calcification and proliferation of the intimal layer of large and medium sized arteries.
Case report:
We present the first case report of successful surgical treatment of severe aortic arch obstruction by calcified plaques mimicking severe coarctation of the aorta and the outcome (of bisphosphonate therapy) in a newborn with GACI. Furthermore, we report the identification of a variant in ATP Binding Cassette Subfamily C, Member 6 (ABCC6) gene, possibly associated with severe early-onset manifestations of GACI.
Conclusion:
This case report highlights the importance of considering GACI in an infant with heart failure, systemic hypertension, and evidence of increased echogenicity of the arterial vessels. We noted the favorable outcome in improving the aortic calcification in our patient after surgical treatment and bisphosphonates therapy. Early diagnosis and treatment improve the long-term prognosis. A better understanding of this rare genetic disease could lead to new therapeutic strategies.
An Unusual Presentation of Spinal Giant Cell Glioblastoma in a 21-Year-Old Female
Authors: Benjamin J Delgado, Leila Moosavi, Ericka Rangel, William Stull, Rahul Dev Polineni, Joseph Chen, Everardo Cobos
Journal: J Investig Med High Impact Case Rep (2019)
Keywords: gbm, giant cell, glioblastoma multiforme, intramedullary, primary spinal cord tumor
MeSH terms: Glioblastoma / diagnosis, Spinal Cord Neoplasms / diagnosis, Case Reports, Review, Combined Modality Therapy, Female, Glioblastoma / diagnostic imaging, Glioblastoma / pathology, Glioblastoma / therapy, Humans, Magnetic Resonance Imaging, Spinal Cord / diagnostic imaging, Spinal Cord / pathology, Spinal Cord Neoplasms / diagnostic imaging, Spinal Cord Neoplasms / pathology, Spinal Cord Neoplasms / therapy, Thoracic Vertebrae, Young Adult

Primary spinal cord giant cell glioblastoma multiforme of the thoracic spinal cord is a rarely-diagnosed primary spinal cord tumor in comparison to neoplasms in intracranial locations. In this article, we highlight a young adult who was diagnosed with intramedullary giant cell glioblastoma, IDH wild-type, World Health Organization grade IV/IV of the thoracic spinal cord. This case report describes the treatment approach with a postsurgical combination of radiation therapy and temozolomide, which resulted in the patient to return to her baseline of health only to later develop neurological symptoms significant for a recurrence of malignancy. In a review of the literature of described cases of primary spinal cord glioblastoma multiforme, prognosis continues to be unfavorable as current treatment options of the aggressive malignancy remain absent of a cure.
Case of hereditary papillary renal cell carcinoma
Authors: Sadaf Mustafa, Nima Jadidi, Sheila F Faraj, Ronald Rodriguez
Journal: J Community Hosp Intern Med Perspect (2012)
Keywords: familial papillary renal cell carcinoma, hepatocyte growth factor/scatter factor, hereditary leiomyomatosis and renal cell carcinoma, met proto-oncogene, renal cancer
MeSH terms: Case Reports

Renal cell carcinoma is the most common type of renal malignancy and it originates from the renal tubular epithelium. Due to the diversity in the histopathological and molecular characteristics, it is typically subclassified into five different categories. Papillary renal cell carcinoma is one subclassification and it includes two variants: sporadic and hereditary. Although the hereditary form comprises a smaller number of cases of papillary renal cell carcinoma, an understanding of the molecular pathways and genetic changes continues to play a significant role in the development of new targeted therapies. Along with recommending appropriate lifestyle modification, further investigation into the molecular pathogenesis of hereditary papillary renal cell carcinoma will continue to be invaluable for the clinical management of renal cell carcinoma. In this article, we discuss a case of the hereditary papillary renal cell carcinoma along with an overview of the disease.
Capnocytophaga canimorsus Bloodstream Infection Associated with an Urticarial Exanthem
Authors: John C Goetzinger, Austin L LaGrow, Dena R Shibib, Sharanjeet K Thind
Journal: Case Rep Infect Dis (2021)
MeSH terms: Case Reports

Background. Capnocytophaga canimorsus is a fastidious, slow-growing, Gram-negative rod that is a commensal bacterium in normal gingival flora of canine and feline species. Infection with the organism may cause disease ranging from flu-like symptoms to disseminated intravascular coagulation (DIC), fulminant sepsis, meningitis, and endocarditis with an overall fatality rate of 6-26%. Risk factors for infection from C. canimorsus include immunosuppression, alcoholism, and asplenia. Case Presentation. We describe an unusual case with a relatively indolent clinical course and an urticarial exanthem in an otherwise young immunocompetent patient with a history of type 1 diabetes. The patient presented to the Emergency Department (ED) with a <1-day history of rhinorrhea, fever, and dyspnea. He met sepsis criteria on initial presentation, but left against medical advice and returned to the ED the following day, with new arthralgias and a diffuse rash, multiple erythematous, tender macules scattered across his trunk and extremities, and tonsillar erythema. He had not taken the doses of the prescribed amoxicillin. Blood cultures two days later signaled positive for growth with the Gram stain showing a Gram-negative rod. Three 7-8 cm tender targetoid lesions with central clearing were identified on the patient's back. The patient reported two nonengorged ticks crawling on his body a week prior and sustaining a dog bite to his ear three weeks before presentation. Ultimately, the organism was identified as C. canimorsus through MALDI-TOF mass spectrometry and additional biochemical testing. He was given appropriate antibiotics and improved clinically thereafter. Despite the patient's bacteremia, he never progressed to fulminant sepsis and followed a mild clinical course with several unusual characteristics. C. canimorsus is an uncommon cause of illness in humans, but is an important pathogen to consider when evaluating a patient with a dog bite, known risk factors, and an urticarial exanthem as empiric treatment may prevent severe outcomes.
Bone lymphoma revealed by cruralgia during pregnancy: a case report
Authors: Ghita Sqalli Houssaini, Latifa Tahiri, Abdelhalim Ibrahimi, Siham Tizniti, Abdelmajid Elmrini, Taoufik Harzy
Journal: Pan Afr Med J (2014)
Keywords: bone lymphoma, non hodgkin lymphoma, pregnancy
MeSH terms: Femoral Neoplasms / diagnosis, Lymphoma, Large B-Cell, Diffuse / etiology, Pain / etiology, Pregnancy Complications, Neoplastic / diagnosis, Case Reports, Abortion, Therapeutic, Adult, Antibodies, Monoclonal, Murine-Derived / administration & dosage, Antineoplastic Combined Chemotherapy Protocols / administration & dosage, Antineoplastic Combined Chemotherapy Protocols / therapeutic use, Bone Nails, Cyclophosphamide / administration & dosage, Doxorubicin / administration & dosage, Female, Femoral Fractures / etiology, Femoral Fractures / surgery, Femoral Neoplasms / drug therapy, Fracture Fixation, Internal, Fractures, Spontaneous / etiology, Fractures, Spontaneous / surgery, Groin, Humans, Lymphoma, Large B-Cell, Diffuse / drug therapy, Magnetic Resonance Imaging, Prednisolone / administration & dosage, Pregnancy, Pregnancy Complications, Neoplastic / drug therapy, Pregnancy Trimester, Second, Rituximab, Vincristine / administration & dosage, Antibodies, Monoclonal, Murine-Derived, Rituximab, Vincristine, Doxorubicin, Cyclophosphamide, Prednisolone, VAP-cyclo protocol

Pregnancy complicated by Non Hodgkin lymphoma (NHL) is rare, about 100 cases have been reported. We will describe the case of a multifocal bone lymphoma revealed by a left hyperalgetic and deficient cruralgia in a female in the second trimester of pregnancy.
Complex Odontome associated with Maxillary Impacted Permanent Central Incisor: A Case Report
Authors: Raghavendra M Shetty, Sangamesh Halawar, Hanumanth Reddy, Sujata Rath, Sunaina Shetty, Anushka Deoghare
Journal: Int J Clin Pediatr Dent (2013)
Keywords: complex odontome, impacted incisor, ligature hook
MeSH terms: Case Reports

Odontomas, the most often seen ones among odontogenic tumors, are usually asymptomatic and discovered in routine radiographic examinations. Frequently it may interfere with the eruption of teeth. The purpose of this article is to present and discuss the case of a 12-year old child with a complex odontome, obstructing the eruption of left maxillary permanent central incisor. Radio opaque calcified masses were revealed in the radiograph and the masses were surgically removed to facilitate the eruption of the tooth. How to cite this article: Shetty RM, Halawar S, Reddy H, Rath S, Shetty S, Deoghare A. Complex Odontome associated with Maxillary Impacted Permanent Central Incisor: A Case Report. Int J Clin Pediatr Dent 2013;6(1):58-61.
Multiple endocrine neoplasia type 1 presenting with concurrent insulinoma and prolactinoma in early-adolescence
Authors: Yasmin Akhtar, Angela Verardo, Janet L Crane
Journal: Int J Pediatr Endocrinol (2018)
Keywords: insulinoma, men1, prolactinoma
MeSH terms: Case Reports

Background:
Multiple Endocrine Neoplasia Type 1 (MEN1) is a rare autosomal dominant disease that generally presents with primary hyperparathyroidism. However, initial presentation may vary and continued reevaluation of etiology of symptoms is required for appropriate diagnosis.
Case presentation:
Twelve year old female presented with altered mental status that self-resolved and hypoglycemia. Laboratory evaluation revealed pituitary dysfunction with central hypothyroidism and adrenal insufficiency in the setting of hyperprolactinemia. Macroadenoma was confirmed on imaging. Despite medical treatment of pituitary hormone disorders, she continued to have significant hypoglycemia and further workup revealed hyperinsulinism. Insulinoma was identified and confirmed by endoscopic ultrasound. Hypoglycemia resolved after laproscopic enucleation of the insulinoma.
Conclusion:
Children presenting with one endocrine tumor should be investigated for other potential endocrine tumors. Multiple imaging modalities may be required to confidently identify neuroendocrine tumors for appropriate surgical intervention.
Prehospital use of the intubating laryngeal mask airway in patients with severe polytrauma: a case series
Authors: Andrew M Mason
Journal: Case Rep Med (2009)
MeSH terms: Case Reports

A case series of five patients is described demonstrating the utility of the intubating laryngeal mask airway in the prehospital setting, both as a primary airway rescue device and as a bridge to tracheal intubation. All patients were hypoxaemic, had sustained severe polytrauma and were trapped in their vehicles following road traffic collisions. A probability of survival study showed better-than-predicted outcomes for the group as a whole.
Multiomic analysis of HER2-enriched and AR-positive breast carcinoma with apocrine differentiation and an oligometastatic course: a case report
Authors: Brando Poggiali, Agostino Ponzetti, Marica Malerba, Fabio Landuzzi, Federica Furia, Debora Charrance, Sara Trova, Vittoria Perseghin, Patrizia A Falcone, Valentina Alliod, Alessandra Malossi, Pierpaolo Carassai, Ubaldo Familiari, Manuela Vecchi, Stefano Gustincich, Marina Schena, Andrea Cavalli, Alessandro Coppe
Journal: Front Oncol (2023)
Keywords: ngs, wgs, apocrine carcinoma, bioinformatic analysis, breast cancer, case report, nanopore, personalized medicine
MeSH terms: Case Reports

Breast carcinoma is the most prevalent cancer among women globally. It has variable clinical courses depending on the stage and clinical-biological features. This case report describes a 56-year-old female with invasive breast cancer without estrogen or progesterone receptor expression, with apocrine differentiation, and with no germline variants in the BRCA1 and BRCA2 genes. Throughout the clinical course, the patient exhibited discordant results for HER2 in immunohistochemistry and in situ hybridization. During the second relapse, the disease displayed apocrine microscopic features. The tumor underwent analysis for the androgen receptor, GCDFP-15, RNA-seq, and whole-genome sequencing (WGS) to identify the breast cancer subtype and to characterize the cancer genome. Our bioinformatic analysis revealed 20,323 somatic SNV/Indels, including five mutations in cancer-related genes that are believed to be responsible for the tumor's development. Two of these mutations were found in the PIK3CA and TP53 genes. Furthermore, the tumor tissue exhibited large copy number alterations to the chromosomes, which could impact gene expression through complex mechanisms and contribute to the tumor phenotype. Clustering algorithms applied on RNA-sequencing data categorized this cancer as a HER2+ subtype. The second-line capecitabine chemotherapy treatment is ongoing, and the patient is responding well. Bioinformatic results support the current treatment decision and open the way to further treatments.
Case Report: A Case With MOGAD and Anti-NMDAR Encephalitis Overlapping Syndrome Mimicing Radiological Characteristics of CLIPPERS
Authors: Jia Guo, Yujie Bu, Wei Liu
Journal: Front Immunol (2022)
Keywords: clippers mimics, mnos, mogad, anti-nmdar encephalitis, autoimmune
MeSH terms: Anti-N-Methyl-D-Aspartate Receptor Encephalitis / diagnostic imaging, Anti-N-Methyl-D-Aspartate Receptor Encephalitis / drug therapy, Connective Tissue Diseases / complications, Case Reports, Humans, Magnetic Resonance Imaging, Myelin-Oligodendrocyte Glycoprotein, Neoplasm Recurrence, Local / complications, Radiography, Syndrome, Myelin-Oligodendrocyte Glycoprotein

Herein, we reported a case of a young man diagnosed with MNOS (anti-myelin oligodendrocyte glycoprotein associated disease (MOGAD) and anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis overlapping syndrome, i.e., MNOS), whose imaging findings in magnetic resonance imaging (MRI) mimicked chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). We reported a case of refractory anti-NMDAR encephalitis that recurred after standard first-line and second-line treatment. The patient presented with CLIPPERS on imaging at recent hospital admission, and his MOG antibodies were seropositive. After intravenous methylprednisolone (IVMP) treatment, the patient's symptoms were significantly alleviated. In this case, we demonstrated that MNOS could mimic the radiological characteristics of CLIPPERS. Future studies should focus on the diagnosis and treatment of antibody overlap syndrome.
Case report: Real-world experience using a personalized cancer-specific circulating tumor DNA assay in different metastatic melanoma scenarios
Authors: Karam Khaddour, Alice Zhou, Omar H Butt, Griffin Budde, Allyson Koyen Malashevich, George Ansstas
Journal: Front Oncol (2022)
Keywords: ctdna, melanoma, metastatic disease, minimal residual disease, molecular residual disease
MeSH terms: Case Reports

Circulating-tumor DNA (ctDNA) has emerged as an important biomarker for monitoring disease status in cancer patients. Different ctDNA testing platforms have shown promising results in the early detection of disease, monitoring response to treatment, and prognostication in metastatic melanoma. However, several challenges exist, including the reduced shedding of ctDNA into the bloodstream in the metastatic setting, differences in sensitivity among various ctDNA assays, and the inherent inability to distinguish tumor-specific mutations from other mutations that are not related to the cancer of interest. Using a ctDNA assay that is designed to detect multiple single-nucleotide variants (SNVs) that are specific to the tumor itself may allow for more accurate monitoring of disease status in metastatic melanoma. In this case series, we describe a real-world experience using a personalized, tumor-informed ctDNA assay to monitor the clinical trajectories of four patients with metastatic melanoma. Our report highlights potential benefits and limitations using ctDNA in this setting to inform clinical decision-making. This report provides a proof of concept of the technique using an mPCR-NGS-based ctDNA assay (Signatera TM) in the clinical context and in adjunct with other radiological information. Large cohort prospective trials would be needed to validate the utility and validity of this approach.
PEEK Implants: An Innovative Solution for Facial Aesthetic Surgery
Authors: Rocco Narciso, Emanuela Basile, Davide Johan Bottini, Valerio Cervelli
Journal: Case Rep Surg (2021)
MeSH terms: Case Reports

The authors present a case report showing their experience with the use of PolyEtherEtherKetone (PEEK) implants as an innovative solution for the skeleton and soft tissues' reshaping in facial aesthetic plastic surgery. This technique offers the surgeon a reliable and effective way to answer patients' request of increasing volume and reshaping the malar area. A fifty-year-old patient complaining about hypoplasia of the malar area, after undergoing three operations of silicon implants' placement and replacement, was still unsatisfied about the symmetry and feeling through the skin of the lower lid, the rim of the prostheses. The authors suggested the use of bone-anchored PEEK implants, to increase the volume and reshape the malar area by a skeleton and soft tissue camouflage. The treatment was planned and previewed on the preop 3-dimensional CT scans for the customization of the implants. Although no cases are reported in international literature on the use of this material in facial aesthetic surgery, this technique seems to offer a safe and effective solution for the treatment of patients asking to increase and modify the shape of their malar area. Custom made PEEK implants are already used in craniofacial reconstructive bony surgery with good results, and 3D CT scan planning is widely used in these cases. No complications were reported in the case reported and the outcomes seem to the authors and to the patient being, finally, satisfactory.