OpenMed/multicare-articles huggingface dataset:
A case of renal cell carcinoma with antiphospholipid syndrome treated by robot-assisted partial nephrectomy
Authors: Yu Tashiro, Satoshi Ishitoya, Ryo Yamamoto, Kyohei Sugiyama, Hideaki Takada, Keiyu Matsumoto, Kazunari Tsuchihashi
Journal: IJU Case Rep (2023)
Keywords: antiphospholipid syndrome, antithrombotic drug, nephrectomy, renal cell carcinoma, robot‐assisted surgery
MeSH terms: Case Reports

Introduction:
Antiphospholipid syndrome is an autoimmune disease that presents with thrombus hyperplasia. Although very rare, this disease is reported to become severe after the surgical invasion and other interventions. To our knowledge, there are no reports of partial nephrectomy in patients with antiphospholipid.
Case presentation:
A 45-year-old man visited our hospital for treatment of left renal cell carcinoma. He had a history of antiphospholipid syndrome and took two antithrombotic agents. We performed a robot-assisted partial nephrectomy. We selectively ligated only the feeding branch during the procedure. Postoperatively, there were no complications, and the patient was discharged on postoperative day 10. One year after surgery, there was no worsening of antiphospholipid syndrome.
Conclusion:
We reported the first case of robot-assisted partial nephrectomy for an antiphospholipid syndrome patient. Selective ligation of the renal artery might not have contributed to the severe antiphospholipid syndrome.
Multiple ossified intracranial and spinal meningiomas: a rare case report and literature review
Authors: Jian Wang, Anbang Zhang, Boya Wang, Jingmeng Yuan, Junchi Zhu, Mengjiao Li, Henli Liu, Lijuan Cheng, Ping Kong
Journal: Front Neurol (2023)
Keywords: case report, meningiomatosis, multiple, ossified intracranial meningiomas, ossified spinal meningiomas
MeSH terms: Case Reports

Ossified intracranial meningiomas (OIM) and ossified spinal meningiomas (OSM) are rare neoplasms of mesenchymal origin that predominantly manifest in the spinal cord and infrequently in the cranial region, accounting for ~0. 7-5.5% of all meningiomas. It is extremely rare to have multiple intracranial and spinal lesions accompanied by ossification. Herein, we report this rare case for the first time. A 34-year-old woman presented with paresthesia and limb weakness in the right lower limb and gradually worsened. Approximately half a year later, she could only walk with crutches. Magnetic resonance imaging of the brain and spinal cord showed multiple meningiomas, and histopathological examination confirmed multiple OIM and OSM (WHO grade 1). Multiple OIM and OSM are extremely rare with diverse imaging features, and it is easily confused with other tumors. Histopathological examination is the final diagnostic method.
An unusual presentation of neonatal rhabdomyosarcoma: a case report
Authors: Danielle Strah, Kelly Stanley, Kelsie Oatmen, Ranjit I Kylat, Megan Dishop, Michelina de la Maza
Journal: Front Pediatr (2023)
Keywords: case report, congenital, metastatic, neonatal, rhabdomyosarcoma
MeSH terms: Case Reports

A full-term infant with an unremarkable prenatal course presented at birth with a large midline facial mass and smaller masses in the head and neck. In addition, multiple diffuse flesh-colored nodules spread along all the upper and lower limbs. An extensive evaluation to cover a broad differential diagnosis of infectious, lymphatic/vascular, and oncologic etiology was undertaken. The initial suspicion was confirmed by biopsy of the skin lesion as congenital alveolar rhabdomyosarcoma (RMS). RMS is the most common soft tissue sarcoma that occurs in childhood. However, neonatal RMS is exceedingly rare. The infant's initial treatment included vincristine, dactinomycin, and cyclophosphamide in addition to salvage ifosfamide and etoposide, which were dose-adjusted for age. Herein, we present a case of an infant with RMS who showed initial improvement before relapsing and succumbing to her disease at 5 months of age. A review of the limited literature available on this rare condition and newer treatment regimens with improved mortality rates is performed.
Autoimmune Hemolytic Anemia Associated with Mature Ovarian Cystic Teratoma Containing Monoclonal Immunoglobulin G: A Case Report and Review of Literature
Authors: Yuma Nato, Keiki Nagaharu, Keika Itoh, Naoki Shinke, Keiko Maeyama, Akihiko Sawaki, Hiroyuki Miyashita
Journal: Case Rep Obstet Gynecol (2024)
MeSH terms: Case Reports

Background:
Autoimmune hemolytic anemia (AIHA) associated with solid tumors such as mature cystic teratomas is rare and poorly understood. Here, we report a successfully treated case of secondary AIHA in a mature cystic teratoma containing antibodies against red blood cells. Case description. A 22-year-old woman was referred to our hospital with progressive anemia. Laboratory findings revealed hemolysis with a positive direct and indirect antiglobulin test. Imaging studies identified a left ovarian mass, suspected to be a mature cystic teratoma, which was later confirmed by histopathology after laparoscopic oophorocystectomy. The patient was treated with prednisolone, resulting in improved anemia. To examine the relationship between the tumor and AIHA, an indirect antiglobulin test was performed on the tumor contents. Stronger aggregations were observed at any concentration diluted by 10 times from 10 to 10,000 times of the tumor contents compared to the patient's serum. Additionally, immunofixation electrophoresis of the tumor contents revealed the presence of monoclonal immunoglobulin G-κ.
Conclusion:
The presence of monoclonal IgG-κ in the tumor suggests intratumoral antibody production as a possible mechanism. Further research is necessary to elucidate the pathogenic relationship between such tumors and AIHA. The report also highlights the importance of considering secondary AIHA in patients with unexplained anemia and solid tumors.
Menopause at work-An organisation-based case study
Authors: Camille Cronin, Joanne Abbott, Nestor Asiamah, Susan Smyth
Journal: Nurs Open (2024)
Keywords: case study research, menopause, workplace
MeSH terms: Menopause, Perimenopause, Review, Adult, Case-Control Studies, Female, Humans, Middle Aged, Research Design, Workforce

Aim:
The aim of the study was to explore and understand the organizational culture of a workplace in terms of support and well-being for staff experiencing perimenopausal and menopausal symptoms at work.
Design:
It is widely acknowledged that perimenopause and menopause symptoms are experienced by a large percentage of the female workforce. There is a lack of research into how nurses are supported through menopause (Cronin et al. Issues in Mental Health Nursing, 42, 2021, 541-548). The perimenopause and menopause transition can be a challenging time where many may require symptom management and support (RCN, The Menopause and Work: Guidance for RCN Representatives, 2020). This paper presents a case study research (CSR) approach to examine one healthcare organization.
Methods:
CSR design was used: A survey distributed to all staff employed, a review of the available documentation on menopause and interviews with managers from different levels of the organization. The COREQ consolidated criteria was used for reporting the qualitative research reported this study.
Results:
The case study generated both quantitative and qualitative data using surveys, interviews and documentation. Data from the organization (n = 6905) showed a majority female workforce of 81.9% with 40.6% aged between 41 and 55 years old, meaning a third of the organization working through perimenopause and menopause. Survey responses (n = 167) collected biographical and psychometric data on the prevalence of perimenopausal and menopausal symptoms. Seven managers were interviewed highlighting two themes: Access to support and culture of menopause and 13 documents from the organization on menopause were analysed for content. The study design permitted an iterative approach to data collection and providing an in-depth understanding of the needs and support for those experiencing perimenopause and menopause. The findings help healthcare organizations to understand their workforce and take in to account the larger numbers of female employees particularly nurses with the need to provide person-centred support mechanisms and an organizational approach for all employees.
Case Report: Inflamed Jacobson nerve: an uncommon cause of persisting otalgia after an acute otitis media
Authors: Aybige Camurdan, Alexander Kilgue, Lars Uwe Scholtz, Ingo Todt
Journal: Front Surg (2024)
Keywords: jacobson's nerve, glossopharyngeal nerve, otalgia, tympanic nerve, tympanoscopy
MeSH terms: Case Reports

Introduction:
Otalgia can have multiple causes. Mostly otalgia is caused by a tubal dysfunction or an acute middle ear infection. This case describes a patient with an inflammation of the Jacobson's nerve causing severe persistent otalgia after an acute otitis media. The patients complaints completely disappeared after neurolysis of the Jacobson's nerve.
Case presentation:
We describe a case of a 21-year-old female caucasian patient with acute otitis media and persistent intractable otalgia. Infection was first successfully controlled by antibiotics. But the patient reported a persistent otalgia not responding to analgetics. We performed a CT scan, which exhibited a regular aerated middle ear finding, and a diagnostic tympanoscopy to examine the middle ear structures particularly the tympanic Jacobson's nerve as a possible cause for persistent pain. The following neurolysis of Jacobson's nerve under general anaesthesia led to a resolution of otalgia.
Conclusion:
An inflamed tympanic Jacobson's nerve is a rare observation and a persisting otalgia after an acute otitis media not responding to conservative treatment can be treated by a neurolysis.
The Use of Lisdexamfetamine to Treat ADHD in a Patient with Stimulant (Methamphetamine) Use Disorder
Authors: J Levine, H Swanson
Journal: Case Rep Psychiatry (2023)
MeSH terms: Case Reports

Introduction:
The treatment of attention deficit hyperactivity disorder (ADHD) with stimulants among patients with stimulant use disorder carries concern for efficacy and exacerbation of addictive behaviors. Lisdexamfetamine is a unique stimulant used to treat ADHD with a lower abuse potential compared to other stimulants, as the medication is the only prodrug in its class. To our knowledge, there are no reports in the literature of the use of lisdexamfetamine to treat ADHD in patients with stimulant use disorder.
Methods:
We present a 33-year-old male with a history of stimulant (methamphetamine) use disorder, who was found to have long-standing ADHD. The patient was treated with lisdexamfetamine 30 mg, which was increased and sustained at 40 mg.
Results:
The patient reported significant improvement in focus, concentration, calmness, organization of thoughts, and less of a tendency to procrastinate. Additionally, he denied exacerbation of anxiety or sleep disturbances. He reported his cravings for stimulants were significantly decreased. After 2 months of treatment, he had moved out from his sober living facility, started a new job, and gained a promotion. He had no use of illicit substances, which was proven by routine urine drug screens.
Conclusion:
Our patient's ADHD was successfully treated with lisdexamfetamine. Not only did the patient's ADHD symptoms improve, but his cravings for stimulants were relieved. ADHD is common among patients with stimulant use disorder. Patients with ADHD and stimulant use disorder should not necessarily forgo pharmacologic treatment with stimulants for concerns of abuse. Due to its unique pharmacokinetic profile, lisdexamfetamine is a feasible treatment for patients with ADHD and a history of stimulant use disorder.
Early Thumb Carpometacarpal Subluxation Stabilized with a Mini TightRope: A Report of Two Cases
Authors: Christopher R Gajewski, Neil F Jones
Journal: J Hand Surg Glob Online (2023)
Keywords: basilar thumb arthritis, hypermobility, instability, suspensionplasty
MeSH terms: Case Reports

Two patients with thumb carpometacarpal instability were stabilized using a suture suspension device. Both patients had symptomatic thumb carpometacarpal instability in the setting of clinical hyperlaxity without known connective tissue disorder that was recalcitrant to nonsurgical modalities. Both patients had significant, lasting improvement in their pain and function with excellent radiographic outcomes. Suture suspension as a treatment for thumb carpometacarpal instability with an intact trapezium is an effective alternative to ligamentous reconstruction that avoids donor site morbidity and may have added benefit in patients with underlying ligamentous laxity.
A novel splicing mutation identified in a DMD patient: a case report
Authors: Yuting Wen, Luo Yang, Gan Shen, Siyu Dai, Jing Wang, Xiang Wang
Journal: Front Pediatr (2023)
Keywords: dmd, duchenne muscular dystrophy, case report, preimplantation genetic diagnosis, splicing mutation
MeSH terms: Case Reports

Background:
Duchenne muscular dystrophy (DMD, ORPHA:98896) is a lethal X-linked recessive disease that manifests as progressive muscular weakness and wasting. Mutations in the dystrophy gene (DMD) are the main cause of Duchenne muscular dystrophy.
Case presentation:
This study aims to determine novel mutations of DMD and help preimplantation genetic diagnosis (PGD) for family planning. Here present a 4-year-old Chinses boy with DMD, whole-exome sequencing (WES) was performed to identify the molecular basis of the disease. It was confirmed that the boy carried a novel hemizygous mutation of NC_000023.11(NM_004006.3): c.5912_5922 + 19delinsATGTATG in DMD which inherited from his mother. This led to the aberrant splicing of DMD which demonstrated by a minigene splicing assay and further resulted in the impairment of the dystrophy protein.
Conclusions:
Our study discovered a novel splicing mutation of DMD in a DMD patient, which expands the variant spectrum of this gene and provide precise genetic diagnosis of DMD for timely therapy. Meanwhile, this finding will supply valuable information for preimplantation genetic diagnosis.
Pica in a girl with non-suicidal self-injury: a case report
Authors: Bo Liu, Lijun Jiang, Minlan Yuan, Hongru Zhu, Wei Zhang
Journal: Front Psychiatry (2023)
Keywords: cbt, mect, nssi, lithium, pica, quetiapine, sertraline
MeSH terms: Case Reports

Non-suicidal self-injury (NSSI) is on the rise globally, posing a significant societal challenge. Pica, an eating disorder, presents difficulties in treatment due to the absence of effective medications. In this report, we discuss a complex case involving the co-occurrence of pica and non-suicidal self-injury. A 13-year-old girl was admitted to our hospital due to ingesting two batteries. She features a persistent, intense appetite along with sudden and compulsive behaviors such as consuming inedible items or self-inflicted cutting. After receiving a combination of pharmacological treatments (quetiapine, lithium and sertraline), cognitive behavioral therapy (CBT) and modified electroconvulsive therapy (MECT) for 25 days, she was discharged with relief from her clinical symptoms.
Where the cerebral infarction meets child, be vigilant about patent foramen ovale: a case report
Authors: Zai-Qiang Zhang, Jia-Wang Ding
Journal: Front Neurol (2024)
Keywords: case report, cerebral infarction, paradoxical embolism, patent foramen ovale (pfo), young child
MeSH terms: Case Reports

Background:
While cerebral infarction in children is rare, its prognosis is poor, and this condition can seriously burden society and families. A correlation between patent foramen ovale (PFO) and ischemic stroke has not been found in pediatric patients.
Case presentation:
We report a 7-year-old boy who suffered from multiple cerebral infarctions. Subsequently, the patient was diagnosed with an abnormal shunt of PFO. He underwent PFO closure and was followed up for 1 year. The patient did not experience any further cerebral infarction.
Conclusions:
With this case report, we want to illustrate that although the incidence rate of ischemic cerebral infarction in adolescents is very low, we should not neglect the role of PFO. Therefore, after exclusion other causes of cerebral infarction, PFO should be considered in adolescent and adult stroke patients with adult closure criteria in the same way.
Cystic Lymphangioma Over the Lower Limb: A Case Report With a Literature Review
Authors: Sagarika S Bhole, Mohd Yunus Shah, Zansher Nazar
Journal: Cureus (2024)
Keywords: congenital, histology and histopathology, lower limb, lymphangioma, mri
MeSH terms: Case Reports

Cystic lymphangioma (CL) is a rare congenital deformity that almost exclusively affects children. Among the incidences, the majority occur in the head and neck area. Adults who develop these lesions likely develop them as a result of trauma. Here, we present the case of an adult female with a CL in the right calf region. Over time, it continued to grow to a noticeable size. Surgical resection was a good management strategy for the patient. We conducted a literature survey in light of scarce reports depicting CL in the limbic area.
Sudden pediatric death unveiling pulmonary arteriovenous malformations
Authors: Hadeel Abu-El-Rub, Rashed Shatnawi, Yahia I AbuZetun, Doaa Ghorab, Ali M Shotar
Journal: Autops Case Rep (2024)
Keywords: arteriovenous malformations, autopsy, forensic pathology, sudden death
MeSH terms: Case Reports

Pulmonary arteriovenous malformations (PAVMs) are abnormal vascular connections between pulmonary arteries and veins, often associated with hereditary hemorrhagic telangiectasia (HHT). Most PAVMs are asymptomatic, but life-threatening complications like pulmonary hemorrhage, brain abscesses, and paradoxical emboli can emerge, so prompt diagnosis and treatment are crucial. We report a case of sudden pediatric death in a two-year-old female with no past medical history. Initial vomiting and fast deterioration resulted in a sudden cardiac arrest. The postmortem examination found histological evidence of consistent, extensive lung damage. The absence of the characteristic symptoms made for some challenges when it came to diagnosis, showing precisely that in early life, you could well have many difficulties in catching PAVMs. This case highlights the need to take PAVMs into account as a potential cause of sudden death, particularly when there are no conspicuous symptoms. Awareness among forensic pathologists and consideration of genetic analysis for HHT in such cases is crucial for accurate diagnosis and management.
Myasthenia Gravis Mimicking Status Asthmaticus: The Hidden Crisis
Authors: Saket Toshniwal, Anil Wanjari, Sourya Acharya, Sunil Kumar, Tushar Sontakke
Journal: Cureus (2024)
Keywords: myasthenia gravis, myasthenic crisis, non-respiratory cause of dyspnea, status asthmatics, subtle signs
MeSH terms: Case Reports

Status asthmaticus is a severe form of aggravation of asthma, whereas myasthenia gravis (MG) is a rare neuromuscular condition characterised by exhaustion and muscle weakness. Myasthenic crisis can occasionally manifest with symptoms that resemble status asthmaticus, which can result in an incorrect diagnosis and ineffective therapy. In addition to discussing the therapeutic implications, this abstract attempts to draw attention to the difficulties in distinguishing between status asthmaticus and myasthenia crisis and the importance of diagnosing subtle signs of MG. In this case, we present a 55-year-old female, with a misdiagnosed case of bronchial asthma, who presented with shortness of breath at rest for two to three days and was suspected to have an acute exacerbating episode of asthma. She was later evaluated for non-respiratory causes of dyspnea on noticing subtle signs of ptosis and was found to have an active myasthenic crisis. Although this case presented typically as status asthmaticus, it did not respond to conventional treatment of it, and on the contrary, it worsened. Hence, it is necessary to look for subtle signs of MG and promptly differentiate it from other similar emergency events to help administer accurate treatment which can prove life-saving.
Unusual adult-onset cardiac rhabdomyomas in tuberous sclerosis complex: a case report
Authors: H A Nati-Castillo, Juan Manuel Quintero, Oswaldo Aguilar Molina, Marlon Arias-Intriago, Fernando P Melgar Muñoz, Juan S Izquierdo-Condoy
Journal: Front Med (Lausanne) (2024)
Keywords: adult onset, cardiac rhabdomyoma, chest pain, echocardiography, tuberous sclerosis
MeSH terms: Case Reports

Background:
Tuberous sclerosis complex is a genetic neurocutaneous autosomal dominant syndrome, characterized by the development of multiple benign tumors (hamartomas) affecting various systems. Heart-benign tumors that result from the complex are called cardiac rhabdomyomas. Unlike hamartomas that occur in other organs, cardiac rhabdomyomas are most prevalent in infants and very young children with tuberous sclerosis complex. We present a case of a young adult with tuberous sclerosis who had an unusually late diagnosis of cardiac rhabdomyomas.
Case report:
A 22-year-old male patient of Afro-descendant, diagnosed with tuberous sclerosis complex in childhood, presented with refractory epilepsy and was treated only with lacosamide. The patient came to medical consultation due to a recent history of episodic, persistent chest pain in the sternal region, associated with physical effort. Echocardiography revealed a non-dilated left ventricle, with several rounded masses of high echogenicity without pedicles at the apical level, the largest measuring 14 × 11 mm, consistent with cardiac rhabdomyomas.
Conclusion:
Cardiac rhabdomyomas rarely develop in adulthood for individuals with tuberous sclerosis. These late-onset cases can exhibit various symptoms, from simple to complex presentations. Regular clinical checkups are essential for adults with tuberous sclerosis complex.
Surgical treatment of anomalous origin of the left pulmonary artery from the descending aorta in a teenager: a case report
Authors: Fuzheng Guo, Simeng Zhang, Zhe Du, Jing Tai, Fengbo Pei, Yi Shi
Journal: Front Cardiovasc Med (2024)
Keywords: aolpa, congenital heart disease, descending aorta, hemoptysis, pulmonary hypertension
MeSH terms: Case Reports

Anomalous origin of one pulmonary artery (AOPA) is a rare congenital heart disease whose symptoms often occur in infancy, and patients have little chance of surviving into adulthood without timely treatments. AOPA is more frequent in infants and toddlers rather than in adults, and it accounts for only 0.12% of all congenital heart disease cases. In all AOPA cases, the right pulmonary artery from the ascending aorta remains common. This study reported a case with anomalous origin of the left pulmonary artery (AOLPA) from the descending aorta in a teenager who underwent double-incision surgery of median sternotomy and left lateral thoracotomies with favorable outcomes.
Bronchopulmonary foregut malformation with severe hemoptysis in advanced age: a case report and literature review
Authors: Cheng-Sen Cai, Bin Li, Yu-Chun Yuan, Li-Na Fu, Xiao-Ye Zhang, Jun Wang
Journal: Front Med (Lausanne) (2024)
Keywords: bpfm, advanced age, case report, hemoptysis, literature review
MeSH terms: Case Reports

Bronchopulmonary foregut malformation (BPFM) is a rare developmental malformation disease due to embryonic defects, with an even rarer occurrence in adults. We report a diagnosed case in an adult patient, and notably, this is the first reported case of such advanced age. Additionally, she experienced coughing up approximately 1 liter of blood and partial lung tissue, accompanied by respiratory failure and shock. Following treatment with transcatheter arterial embolization, her condition improved, and she has remained stable during follow-up. We present a case report and conducted a systematic review on this particular case.