OpenMed/multicare-articles huggingface dataset:
Intraductal Carcinoma of the Parotid Gland as a Rare Neoplasm: A Case Report and Literature Review
Authors: Eugénie Delaine, Andrea Avagnina, Stéphane Yerly, Sara Fontanella, Abderrahmane Hedjoudje, Bassel Hallak, Salim Bouayed, Asimakis D Asimakopoulos
Journal: Ethiop J Health Sci (2023)
Keywords: foci of invasion, immunohistochemistry, intercalated duct carcinoma, intraductal carcinoma, low-grade salivary duct carcinoma, parotid carcinoma
MeSH terms: Carcinoma, Intraductal, Noninfiltrating / pathology, Parotid Neoplasms / diagnosis, Parotid Neoplasms / pathology, Parotid Neoplasms / surgery, Review, Case Reports, Biopsy, Fine-Needle, Humans, Immunohistochemistry, Male, Parotid Gland / surgery

Background:
Intraductal carcinoma is a rare low grade neoplasm of salivary glands with an excellent prognosis. It most frequently occurs in the parotid gland. Ectopic localizations are quite rare.
Methods:
This case report describes a man in his 60's who was referred to ear, nose and throat outpatient department with 1-month history of painless swelling of the right parotid region.
Results:
Ultrasound-guided fine-needle aspiration unveiled a cytologic specimen judged as "suspicious for malignancy" and patient underwent a partial superficial parotidectomy. Immunohistochemistry confirmed diagnosis of intraductal carcinoma of right parotid gland.
Conclusions:
There are few reported cases concerning this clinical entity following thorough review of the literature and recent developments with reference to the contribution of cytology and histopathology will probably modify its classification and management.
The absence of the verumontanum at voiding cystourethrography as a sign of prostate maldevelopment
Authors: A L Valentini, P Ferrara, C Manzoni, A P Mancini, S Pulitanò, L Bonomo
Journal: Adv Urol (2011)
MeSH terms: Case Reports

Prostate maldevelopment in prune-belly syndrome has only been described at necropsy. No reports are available in the "in vivo" studies. The absence of the verumontanum at voiding cystourethrography correlates with verumontanum and prostate hypoplasia. This radiographic sign can represent the earliest finding in prostate maldevelopment and might contribute to the "in vivo" assessment of the disease, especially in doubtful cases.
Multiple Arterial Thrombosis Related with Cantharidin Ingestion
Authors: Zehra Narli Ozdemir, Ugur Sahin, Sinem Civriz Bozdag, Osman Ilhan
Journal: Case Rep Hematol (2018)
MeSH terms: Case Reports

Inherited and/or acquired thrombophilic defects can result in venous or arterial thrombosis. This case report describes arterial thrombotic episodes triggered by the ingestion of an aphrodisiac remedy containing cantharidin in a 46-year-old female patient later discovered to be heterozygous for prothrombin G20210A mutation and seropositive for anti-β2 glycoprotein-I (anti-β2-GPI) antibodies of IgA isotype.
Case report: KPTN gene-related syndrome associated with a spectrum of neurodevelopmental anomalies including severe epilepsy
Authors: Svea Horn, Magdalena Danyel, Nina Erdmann, Felix Boschann, Cecilia Gunnarsson, Saskia Biskup, Jerome Juengling, Cornelia Potratz, Christine Prager, Angela M Kaindl
Journal: Front Neurol (2023)
Keywords: kptn gene, epilepsy, macrocephaly, neurodevelopment delay, splice site variant
MeSH terms: Case Reports

Biallelic variants in the kaptin gene KPTN were identified recently in individuals with a novel syndrome referred to as autosomal recessive intellectual developmental disorder 41 (MRT41). MRT41 is characterized by developmental delay, predominantly in language development, behavioral abnormalities, and epilepsy. Only about 15 affected individuals have been described in the literature, all with primary or secondary macrocephaly. Using exome sequencing, we identified three different biallelic variants in KPTN in five affected individuals from three unrelated families. In total, two KPTN variants were already reported as a loss of function variants. A novel splice site variant in KPTN was detected in two unrelated families of this study. The core phenotype with neurodevelopment delay was present in all patients. However, macrocephaly was not present in at least one patient. In total, two patients exhibited developmental and epileptic encephalopathies with generalized tonic-clonic seizures that were drug-resistant in one of them. Thus, we further delineate the KPTN-related syndrome, especially emphasizing the severity of epilepsy phenotypes and difficulties in treatment in patients of our cohort.
A Rare Cause of Lobular Panniculitis: Munchausen's Syndrome
Authors: Ajili Faida, Smiti Khanfir Monia, Hamzaoui Amira, Ben Ghorbel Imed, Lamloum Mounir, Houman Mohamed Habib
Journal: Case Rep Med (2012)
MeSH terms: Case Reports

We describe a case of a 40-year-old woman who presented with ecchymoses of the right leg and who was found to have lobular panniculitis in biopsy due to Munchausen's Syndrome.
Purpura with regular shape in an adolescent: Beware of dermatitis artefacta
Authors: Yuhao Chen, Lin Li, Jing Lu
Journal: Front Pediatr (2022)
Keywords: dermatitis artefacta, multidisciplinary team, painful purpura, psychiatric disease, rapid diagnostic
MeSH terms: Case Reports

Background:
Purpura is common in pediatric patients, mostly diagnosed as IgA-related vasculitis (Henoch-Schönlein purpura), idiopathic thrombocytopenic purpura (ITP), and thrombotic thrombocytopenic purpura (TTP). However, in some cases, for example, cases with dermatitis artefacta, it could puzzle a physician or pediatrician for a long time, with great challenges in diagnosis.
Case presentation:
We present the case of a 13-year-old boy with recurrent painful purpura on both upper limbs. The physical exam was unremarkable, except for right blepharoptosis and scars from burns. The diagnostic tests were normal. Through repeated communication, the patient was finally diagnosed as having dermatitis artefacta, accompanied by underlying psychological problems.
Conclusions:
Before dermatitis artefacta was diagnosed, we spent a lot of money and effort on the diagnosis. Therefore, in order to determine the diagnosis as soon as possible and save on unnecessary medical expenses, we propose a rapid process for the diagnosis of purpura of dermatitis artefacta in children.
Angiomatoid Fibrous Histiocytoma, A Great Mimicker -A Short Series of 3 Cases with EWSR1 Fusion
Authors: C Aparna Devi, Ashwini Nargund, Geeta V Patil Okaly, Usha Amirtham
Journal: Iran J Pathol (2023)
Keywords: angiomatoid fibrous histiocytoma, ewsr1 fusion, fibrous histiocytoma
MeSH terms: Case Reports

Angiomatoid Fibrous histiocytoma (AFH) is a rare soft tissue neoplasm that is often misdiagnosed initially. It is commonly encountered in the superficial extremities of children and young adults. It is composed of a nodular proliferation of bland looking spindled to ovoid cells, some with variant histology and characterized by EWSR1 fusion. We, herein, present three such cases, who presented with swelling in the right leg (case 1), right forearm (case 2), and right thigh (case 3). Case 2 presented in the fourth decade with a large swelling compared to the other two cases that presented in 3rd decade with a small swelling. Histologic examination of case 2 showed extensive myxoid changes making it diagnostically challenging. All three cases showed EWSR1 fusion with a break-apart probe. Follow-up was uneventful in all three cases. AFH, although it is a benign neoplasm, is a great mimicker of various low-grade spindle cell sarcomas. Awareness of this entity with its various histomorphological variants is necessary to accurately diagnose this lesion.
Case Reports: Bronchial Mucosal Vasculature Is Also Involved in the Acute Vascular Distress Syndrome of COVID-19
Authors: Vincent Jounieaux, Damien Basille, Bénédicte Toublanc, Claire Andrejak, Daniel Oscar Rodenstein, Yazine Mahjoub
Journal: Front Med (Lausanne) (2021)
Keywords: avds, nbi (narrow band imaging), sars-cov-2, bronchovideoscopy, intrapulmonary shunt
MeSH terms: Case Reports

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which targets the pulmonary vasculature is supposed to induce an intrapulmonary right to left shunt with an increased pulmonary blood flow. We report here what may be, to the best of our knowledge, the first videoendoscopic descriptions of an hypervascularization of the bronchial mucosa in two patients hospitalized for coronavirus disease 2019 (COVID-19) pneumonia. Cases Presentation: Two patients, 27- and 37-year-old, were addressed to our Pneumology department for suspicion of COVID-19 pneumonia. Their symptoms (fever, dry cough, and dyspnoea), associated to pulmonary ground glass opacities on thoracic CT, were highly suggestive of a COVID-19 disease despite repeated negative pharyngeal swabs RT-PCR. In both patients, bronchoscopy examination using white light was unremarkable but NBI bronchoscopy revealed a diffuse hypervascularization of the mucosa from the trachea to the sub-segmental bronchi, associated with dilated submucosal vessels. RT-PCR performed in bronchoalveolar lavage (BAL) confirmed the presence of Sars-CoV-2. Conclusions: These two case reports highlight the crucial importance of the vascular component of the viral disease. We suggest that such bronchial hypervascularization with dilated vessels contributes, at least in part, to the intrapulmonary right to left shunt that characterizes the COVID-19 related Acute Vascular Distress Syndrome (AVDS). The presence of diffuse bronchial hypervascularization in the context of COVID-19 pandemic should prompt the search for Sars-CoV-2 in BAL samples.
The Pathogenicity of BPI-ANCA in a Patient With Systemic Vasculitis
Authors: Sayo Takeda, Kanako Watanabe-Kusunoki, Daigo Nakazawa, Yoshihiro Kusunoki, Saori Nishio, Tatsuya Atsumi
Journal: Front Immunol (2019)
Keywords: anca-associated vasculitis, bpi-anca, bactericidal/permeability-increasing protein (bpi), immunity, neutrophil extracellular traps (nets)
MeSH terms: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / immunology, Antibodies, Antineutrophil Cytoplasmic / metabolism, Neutrophils / immunology, Case Reports, Aged, Extracellular Traps / metabolism, Humans, Male, Tumor Necrosis Factor-alpha / metabolism, Antibodies, Antineutrophil Cytoplasmic, TNF protein, human, Tumor Necrosis Factor-alpha

Objective: ANCA associated vasculitis (AAV) is characterized by systemic necrotizing vasculitis with the presence of ANCA. Although BPI-ANCA is one of the atypical ANCAs and is occasionally seen in patients with vasculitis, the pathogenicity of BPI-ANCA remains unclear. This study was performed to examine the pathogenic role of BPI-ANCA against neutrophils. Methods: A 76-year-old Japanese man showed BPI-ANCA positive systemic vasculitis with a medical history of Pseudomonas aeruginosa infection. BPI-ANCA IgGs were eluted from the patient serum using an immunoadsorbent column. In vitro experiment, healthy donor neutrophils were treated with BPI-AAV IgGs, MPO-AAV IgGs, healthy control IgGs under TNFα stimulation. After 3 h incubation, neutrophil extracellular trap (NET) was assessed by immunofluorescent imaging. To determine the pathogenicity of BPI-ANCA, TNFα-primed neutrophils were incubated with monoclonal BPI-ANCA in the presence or absence of recombinant BPI. Results: BPI-AAV IgGs-treated neutrophils showed NET formation with histone citrullination. Interestingly, the monoclonal BPI-ANCA did not induce NET, but the immune complexes (ICs) of recombinant BPI and BPI-ANCA induced TNFα-dependent NET formation with hypercitrullination. Furthermore, TNFα increased the expression of BPIs in neutrophils and the BPIs were translocated to cell surface. Conclusion: BPI-ANCA could affect neutrophils leading to NET formation and may play a role in the development of systemic vasculitis as pathogenic autoantibody.
Laparoscopic Heminephrectomy of Chronically Obstructed Horseshoe Kidney Moiety with Staghorn Calculus, Massive Pyonephrosis, and Xanthogranulomatous Pyelonephritis
Authors: Adrian Fernandez, Benjamin Sherer, Marshall L Stoller
Journal: J Endourol Case Rep (2018)
Keywords: horseshoe kidney, laparoscopy, pyonephrosis, staghorn calculus
MeSH terms: Case Reports

Laparoscopic heminephrectomy was performed in a 64-year-old woman with a chronically obstructed horseshoe kidney moiety. More than 3000 cc of pyonephrosis was drained through two percutaneous nephrostomy tubes for infection control before left moiety laparoscopic resection. This case report attests to the feasibility of laparoscopic resection of a massively obstructed horseshoe kidney when performed in a staged manner after prolonged drainage. Since an incision was required for removal of the large specimen, ligation of the horseshoe isthmus was completed through the same incision after hilar control and laparoscopic mobilization of the moiety were completed.
Imaging findings of primary epithelioid sarcoma of adrenal gland: a case report and literature review
Authors: Hongyu Yin, Yi Zhang, Linyun Wu, Ji Zhang
Journal: Front Oncol (2023)
Keywords: ct, mri, adrenal gland, imaging findings, primary epithelioid sarcoma
MeSH terms: Case Reports

Epithelioid sarcoma (ES) is a rare soft tissue malignant tumor with an uncertain histogenetic origin. It usually arises in soft tissues of the extremities, while ES in adrenal gland is extremely rare. There is no special clinical manifestation in the early stage, so it may be misdiagnosed and delay the treatment. We reported a 69-year-old male with an adrenal ES. The tumor was completely resected, and two months later, positron emission tomography-computed tomography(PET/CT) noted recurrence at the tumor bed and multiple metastases. The patient has been treated with chemotherapy with good effects. We summarize the radiological findings and immunohistochemical indexes of primary epithelioid sarcoma of adrenal gland, which may be useful to promote disease awareness and help to distinguish among other lesions.
Double Cystic Duct: Preoperative use of MRCP Without Being Aware of the Anatomic Anomaly: A Case Report
Authors: Zhi Liang, Junsheng Chen, Yonggui Liang, Jijun Wang, Xiaobiao Song
Journal: Front Surg (2022)
Keywords: mrcp, case report, double cystic duct, gallbladder, laparoscopic cholecystectomy
MeSH terms: Case Reports

Introduction:
A biliary anomaly is occasionally encountered, however, a double cystic duct is exceedingly rare during surgery. It is pivotal for surgeons to recognize the anatomic variations in Cholangiography which is performed under fluoroscopic guidance Intraoperatively to prevent possible complications.
Case presentation:
Herein, the case of a 66-year-old female patient with acute cholecystitis, in which preoperative Magnetic Resonance Cholangiopancreatograph (MRCP) did not identify a single gallbladder with double cystic ducts, is presented. Intraoperatively we identified a double cystic duct and it was safely ligated with clips. Anatomic variability was also confirmed by Cholangiography which was performed under fluoroscopic guidance. Furthermore, the patient was symptom-free through 1 year of follow-up assessment.
Conclusions:
In particular, when we do not identify anatomic variability based on imaging, cholangiography under fluoroscopic guidance during surgery was a powerful tool that may clearly show the anomaly of a single gallbladder with double cystic ducts.
Pediatrics Ewing's Sarcoma of the Sinonasal Tract: A Case Report and Literature Review
Authors: Ahmed Aldandan, Ali Almomen, Abdulrahman Alkhatib, Ghaleb Alazzeh
Journal: Case Rep Pathol (2019)
MeSH terms: Case Reports

Ewing's sarcoma (ES) is a highly malignant, small, round cell tumor that originates from the primitive neuroectodermal cells. Primary ES commonly occurs in early childhood or adolescence. It may present with skeletal and extraskeletal forms. The extraskeletal form is rarely encountered in the head and neck region and is extremely rare in the sinonasal tract. This is a case report of sinonasal ES in a 13-year-old female patient who presented with a 7-month history of right nasal obstruction, anosmia, intermittent epistaxis, snoring, and hearing loss. Clinical examination revealed a right nasal mass pushing the septum to the left side and extending to the nasopharynx. Endoscopic biopsy and histopathological analysis showed a small blue cell tumor suggestive of ES. The patient was treated with surgery, radiotherapy, and chemotherapy. After a follow-up of 5 years, the patient remains recurrence-free with excellent functional status and quality of life.
Diogenes Syndrome: Identification and Distinction from Hoarding Disorder
Authors: Carmel Proctor, Sakib Rahman
Journal: Case Rep Psychiatry (2021)
MeSH terms: Case Reports

"Severe domestic squalor" or Diogenes syndrome is characterised by extreme self-neglect of environment, health, and hygiene, excessive hoarding, squalor, social withdrawal, and a distinct lack of concern or shame regarding one's living condition. This report presents a case of a 51-year-old male admitted to the hospital psychiatric ward following the police removing him from his home. Police officers attended the man's home following the alarm being raised by his stepfather that he had not been seen or heard from in 3 weeks. His home was covered in several feet of rubbish, rotting food, and debris and smelled intensely of rotting mould, urine, and faeces. He was found lying nude on top of garbage with a rug over him. Diogenes syndrome is highly comorbid with psychiatric and somatic disorders, including depression, obsessive-compulsive disorder, personality disorder, and stress. This case report provides a rare opportunity to better understand the distinction of Diogenes syndrome from the closely related condition hoarding disorder. Furthermore, creating an agreed-upon constellation of symptoms representative of Diogenes is essential to creating a formal Diagnostic and Statistical Manual of Mental Disorders (DSM) entry, which would facilitate the much-needed development of assessment measures to enable accurate diagnosis and treatment.
Solar radiation and vitamin D: mitigating environmental factors in autoimmune disease
Authors: Gerry K Schwalfenberg
Journal: J Environ Public Health (2012)
MeSH terms: Autoimmune Diseases / therapy, Purpura, Thrombocytopenic, Idiopathic / therapy, Ultraviolet Rays, Vitamin D / therapeutic use, Case Reports, Review, Autoimmune Diseases / etiology, Female, Humans, Middle Aged, Purpura, Thrombocytopenic, Idiopathic / etiology, Treatment Outcome, Vitamin D

This paper looks at the environmental role of vitamin D and solar radiation as risk reduction factors in autoimmune disease. Five diseases are considered: multiple sclerosis, type 1 diabetes, rheumatoid arthritis, autoimmune disease of the thyroid, and inflammatory bowel disease. Clinical relevant studies and factors that may indicate evidence that autoimmune disease is a vitamin D-sensitive disease are presented. Studies that have resulted in prevention or amelioration of some autoimmune disease are discussed. An example of the utility of supplementing vitamin D in an unusual autoimmune disease, idiopathic thrombocytic purpura, is presented.
A Case of Profound Bradycardia in Endurance Athlete with Severe Anorexia Nervosa
Authors: John Pueringer, Joseph Cinderella, M Greg Treuth
Journal: Case Rep Cardiol (2022)
MeSH terms: Case Reports

We present a case of a 54-year-old woman with asymptomatic bradycardia who was referred for consideration of a pacemaker for profound chronic sinus bradycardia (heart rate is 33 beats per minute). Further, history and physical revealed a self-described endurance athlete with severe anorexia nervosa (AN). Background. Anorexia nervosa and endurance training are known contributors to bradycardia; however, profound asymptomatic sinus bradycardia in the 20-30 beats per minute is underdocumented in the literature and not a common presentation in any setting. The decision to implant a permanent pacemaker could potentially lead to further physical and psychological repercussions in such a frail patient.
Volumetric arc therapy for total scalp irradiation: case report for a recurrent basal cell carcinoma of the scalp
Authors: Francisco Lozano, Naipy Perez, Alejandro Iglesias, Xiaodong Xu, Marco A Amendola, Michael Scott, Erich Companioni, Beatriz E Amendola
Journal: Ecancermedicalscience (2017)
Keywords: bcc, volumetric arc therapy, skin cancer, total scalp irradiation
MeSH terms: Case Reports

Total scalp irradiation may be used to treat numerous conditions including squamous and basal cell carcinomas. These conditions are relatively uncommon and patients are frequently treated with palliative intent. In this report, we describe a volumetric arc therapy technique using photon beams for curative intent in an 84 years old patient with recurrent basal cell carcinoma of the scalp. Dose was 50Gy (2Gy per session) to the planning target volume (PTV) followed by a 10 Gy boost to the macroscopic disease on the forehead. A custom made 1 cm superflab bolus helmet was used. Toxicities only consisted of Grade-1 transient radiation dermatitis and alopecia. A sustained clinical response was observed at 6 months follow-up. Volumetric arc therapy (VMAT) may offer an effective alternative modality to treat patients with very extensive scalp lesions as described in this case report.
Henoch-Schönlein Purpura Presenting in Association With Neuroblastoma: A Case Report
Authors: Zineb Alfath, Asmaa Ferdjallah, Emily Greengard, Sabeen K Askari, Karim T Sadak, Colleen K Correll
Journal: Front Pediatr (2020)
Keywords: henoch-schönlein purpura, case report, neuroblastoma, pediatrics, rash
MeSH terms: Case Reports

Henoch-Schönlein purpura (HSP) is a common systemic vasculitis affecting children. It is managed in the outpatient setting and rarely associated with malignancy. We present a case of neuroblastoma in a 7-year-old boy diagnosed after suspected HSP. Our case highlights the importance of maintaining a broad differential diagnosis in children with atypical HSP and performing a skin biopsy with immunofluorescence when a rash is present.
Invasive Nontyphoidal Salmonella Infection in a Patient with Early-Stage Chronic Lymphocytic Leukemia
Authors: Deepika Slawek, Yanina Dubrovskaya, Eddie Louie
Journal: Case Rep Infect Dis (2017)
MeSH terms: Case Reports

We describe a case of a 72-year-old man with early-stage chronic lymphocytic leukemia (CLL) who presented with invasive nontyphoidal Salmonella (iNTS) infection, necrotizing pneumonia, and chronic infection of a hilar lymph node. Infection is a major cause of death in patients with CLL. Though few cases of iNTS infection associated with CLL have been described in the literature, to our knowledge this is the first reported case of iNTS-associated necrotizing pneumonia. Immunocompromised state in patients, even with early-stage CLL, likely predisposes them to invasive infection with intracellular organisms, such as Salmonella spp. In this case, successful treatment was achieved with prolonged course of intravenous followed by oral antibiotics without any surgical removal of infected focus.