OpenMed/multicare-articles huggingface dataset:
Lung adenocarcinoma concurrent with congenital pulmonary aplasia of the right upper lobe: A case report
Authors: Bo Min, Chu-Xu Wang, Juan Liu, Li Gong, Cheng-Xiang Wang, Xiao-Hua Zuo
Journal: Front Oncol (2022)
Keywords: 3d ct reconstruction, cpd, lung abnormalities, lung adenocarcinoma, pulmonary aplasia
MeSH terms: Case Reports

Lung adenocarcinoma, the most common subtype of lung cancer, has been always imposed serious threat to human health. Congenital pulmonary dysplasia (CPD) lacking typical clinical manifestations is a rare developmental anomaly. Pulmonary aplasia, the rarest subtype of CPD, may present with a variety of symptoms and is frequently associated with other abnormalities. This report describes an 81-year-old woman who presented with an irritant cough. Chest computed tomography (CT) and three-dimensional (3D) reconstruction revealed an irregular mass with a diameter of 5 cm in right lower lobe adjacent to the hilum. CT also indicated a rightward mediastinal shift and the complete absence of ipsilateral upper lobar tissue with bronchus ending in a terminal cecum, resulting in a diagnosis of pulmonary aplasia. The patient accepted lobectomy and lymph node dissection without complication, histopathologic examination combined HE staining with immunohistochemistry identified the tumor as adenocarcinoma. Three months after surgery, the patient was free of respiratory symptoms without chest pain. This report highlights the necessity of comprehensive evaluation for lung malignancy concurrent with CPD and the importance of identifying the diagnosis of pulmonary dysplasia.
Case report: Hepatectomy with Rex bypass for a child with hepatoblastoma and portal vein thrombosis
Authors: Norihiko Kitagawa, Masato Shinkai, Fumio Asano, Yukihiro Tsuzuki, Kyoko Mochizuki, Hidehito Usui, Yuma Yagi, Akio Kawami, Kazuyoshi Okumura, Tomoko Yokosuka, Hiroaki Goto, Kumiko Nozawa, Mio Tanaka
Journal: Front Pediatr (2023)
Keywords: rex bypass, hepatectomy, hepatoblastoma (hbl), liver preservation, portal occlusion
MeSH terms: Case Reports

Pediatric liver tumors with portal vein obstruction are often candidates for liver transplantation. However, lifelong use of immunosuppressants and invasiveness to healthy donors in the case of living-donor liver transplantation is inevitable. Moreover, when lung metastasis is involved, the lung recurrence rate after liver transplantation is still high. Therefore, transplantation should be avoided as much as possible. In cases of tumors in the right lobe of the liver, complete resection of the portal vein trunk may be possible by creating a Rex bypass, but with the original method, end-to-side anastomosis to the umbilical portal vein is difficult in small children. We report a case of a 2-year-old girl with hepatoblastoma in whom a Rex shunt was created by end-to-end anastomosing the recanalized umbilical vein to the portal vein stump with interposing a vein graft, and the right lobe was successfully resected along with the tumor.
First successful case of in vitro fertilization-embryo transfer with venom immunotherapy for hymenoptera sting allergy
Authors: Eric Scott Sills, Susan C Conway, Carolyn R Kaplan, Mark Perloe, Michael J Tucker
Journal: Clin Mol Allergy (2004)

BACKGROUND: To describe immune and endocrine responses in severe hymenoptera hypersensitivity requiring venom immunotherapy (VIT) during in vitro fertilization (IVF). CASE PRESENTATION: A 39-year old patient was referred for history of multiple miscarriage and a history of insect sting allergy. Four years earlier, she began subcutaneous injection of 100 mcg mixed vespid hymenoptera venom/venom protein every 5-6 weeks. The patient had one livebirth and three first trimester miscarriages. Allergy treatment was maintained for all pregnancies ending in miscarriage, although allergy therapy was discontinued for the pregnancy that resulted in delivery. At our institution ovulation induction incorporated venom immunotherapy (VIT) during IVF, with a reduced VIT dose when pregnancy was first identified. Serum IgE was monitored with estradiol during ovulation induction and early pregnancy. Response to controlled ovarian hyperstimulation was favorable while VIT was continued, with retrieval of 12 oocytes. Serum RAST (yellow jacket) IgE levels fluctuated in a nonlinear fashion (range 36-54%) during gonadotropin therapy and declined after hCG administration. A healthy female infant was delivered at 35 weeks gestation. The patient experienced no untoward effects from any medications during therapy. CONCLUSION: Our case confirms the safety of VIT in pregnancy, and demonstrates RAST IgE can remain <60% during IVF. With proper monitoring, VIT during IVF can be safe and appropriate for selected patients and does not appear to adversely affect blastocyst implantation, early embryo development or perinatal outcome. Further studies will be needed to develop VIT guidelines specifically applicable to IVF.
Two unusual gastrointestinal foreign bodies
Authors: Ahmed H Al-Salem
Journal: ISRN Surg (2011)
MeSH terms: Case Reports

Swallowed foreign bodies are common in the pediatric age group, but fortunately, the majority of them pass spontaneously without any adverse effects. Tube gastrostomy is an excellent method to provide prolonged enteral feeding. It is, however, associated with complications, namely, intraperitoneal leak and distal migration of the gastrostomy tube causing gastric outlet obstruction. This paper describes two unusual gastrointestinal foreign bodies, one was swallowed, while the other one was a complication of a tube gastrostomy.
The Modified Caldwell-Luc Approach with the Use of Collagen Material for Treatment of a Chronic Perforated Maxillary Sinusitis
Authors: Ekaterina Diachkova, Elena Morozova, Natalia Blagushina, Svetlana Tarasenko
Journal: Case Rep Dent (2020)
MeSH terms: Case Reports

Oroantral fistula (OAF) often develops after extraction of posterior maxillary teeth and requires surgical closure. If it persists, OAF may result in maxillary sinusitis. This paper reports a case of an oroantral fistula, associated with chronic maxillary sinusitis. A 46-year-old female patient presented with a history of traumatic tooth extraction, which led to OAF formation. Three unsuccessful attempts were made to close it elsewhere. With one operation, we performed Caldwell-Luc surgery and closed OAF with a collagen membrane and plug and a buccal flap. The patient was assessed at 1-, 3-, 6-, and 12-month and 8-year follow-up visits, with no signs of maxillary sinusitis or OAF recurrence being found with the efficient amount of bone and opportunity for further dental rehabilitation like sinus lifting and dental implantation. We believe that this approach may be a viable option in similar cases.
A case of squamous cell carcinoma of the skin due to the molecularly confirmed Lynch Syndrome
Authors: Steven Sorscher
Journal: Hered Cancer Clin Pract (2015)
Keywords: colon cancer, lynch, squamous
MeSH terms: Case Reports

Patients with Lynch Syndrome are at high risk for developing a variety of cancers including cancers of the colon or rectum, small bowel, stomach, uterus, renal pelvis, ureter, biliary tract, ovaries, brain and pancreas (N Engl J Med 348: 919-32, 2003; Gut 57:1097-101, 2008; NCCN, Inc Guideline. Ft. Washington, PA. Online Version 2.2014). Lack of MLH-1 and MSH-2 expression commonly result from germline mutations in this inherited cancer syndrome. Here, we report the case of a patient with a molecularly confirmed germline mutation in MLH-1 along with a colon cancer showing lack of expression of MLH-1 as well as a squamous cell cancer of the skin from the abdominal wall also demonstrating lack of expression of MLH-1. This case appears to represent the second case report of a squamous cell skin cancer apparently due to the Lynch Syndrome and further supports a proposed relationship between Lynch Syndrome and these tumors.
Bipolar disorder and multiple sclerosis: a case series
Authors: Youssef Sidhom, Mouna Ben Djebara, Yosr Hizem, Istabrak Abdelkefi, Imen Kacem, Amina Gargouri, Riadh Gouider
Journal: Behav Neurol (2014)
MeSH terms: Bipolar Disorder / complications, Multiple Sclerosis / complications, Case Reports, Adult, Antipsychotic Agents / therapeutic use, Bipolar Disorder / drug therapy, Female, Humans, Male, Treatment Outcome, Young Adult, Antipsychotic Agents

Background:
The prevalence of psychiatric disturbance for patients with multiple sclerosis (MS) is higher than that observed in other chronic health conditions. We report three cases of MS and bipolar disorder and we discuss the possible etiological hypothesis and treatment options.
Observations:
All patients fulfilled the McDonald criteria for MS. Two patients were followed up in psychiatry for manic or depressive symptoms before developing MS. A third patient was diagnosed with MS and developed deferred psychotic symptoms. Some clinical and radiological features are highlighted in our patients: one manic episode induced by high dose corticosteroids and one case of a new orbitofrontal MRI lesion concomitant with the emergence of psychiatric symptoms. All patients needed antipsychotic treatment with almost good tolerance for high dose corticosteroids and interferon beta treatment.
Conclusions:
MRI lesions suggest the possible implication of local MS-related brain damage in development of pure "psychiatric fits" in MS. Genetic susceptibility is another hypothesis for this association. We have noticed that interferon beta treatments were well tolerated while high dose corticosteroids may induce manic fits.
Retrograde Balloon Dilation outside the Main Branch Stent to Restore the Occlusion of Side Branch in Chronic Total Occlusion Bifurcation Lesions
Authors: Gao Hao-Kao, Li Cheng-Xiang
Journal: Case Rep Cardiol (2020)
MeSH terms: Case Reports

Percutaneous coronary intervention (PCI) of a chronic total occlusion (CTO) can be challenging when a bifurcation is present at the distal cap. We described a case of retrograde balloon outside the main branch stent to restore the occlusion of side branch in CTO bifurcation lesion through the jailed wire.
Delayed fenestration of Blake's pouch with or without vermian hypoplasia: fetal MRI at 3 tesla versus 1.5 tesla
Authors: Thomas Kau, Robert Birnbacher, Peter Schwärzler, Sandra Habernig, Hannes Deutschmann, Eugen Boltshauser
Journal: Cerebellum Ataxias (2019)
Keywords: cerebellar vermis, cranial fossa, posterior, fetus, magnetic resonance imaging, prenatal diagnosis
MeSH terms: Case Reports

Background:
Fetal magnetic resonance imaging (MRI), mainly performed at standard field strength, plays a role in the classification of posterior fossa malformations. In the context of early second-trimester screening, upward rotation of the cerebellar vermis per se is usually compatible with a more favorable outcome than Dandy-Walker malformation and profound vermian hypoplasia. Delayed fenestration of Blake's pouch may either mimic vermian hypoplasia by compression or be associated with it in individual cases. To increase specificity, there is a growing interest in the use of high-field MRI which is believed to be safe as long as the specific absorption rate is kept within accepted limits. We aim to illustrate its added value during the second and third trimester.
Case presentation:
In the first case, fetal MRI at 1.5 Tesla was performed at 21 and 27 weeks' gestation with sonographic follow up postnataly. In the second case, 3 Tesla MR images were acquired at 21 and 34 weeks' gestation as well as in the neonatal period.
Conclusions:
This pictorial case vignette supports the suggestion that mid-gestational MRI at 3 Tesla has the potential to exclude pronounced vermian hypoplasia with higher confidence than at 1.5 Tesla. However, the discrimination of mild hypoplasia from slight deformation of the cerebellar vermis will likely remain challenging.
Case report: Prazosin augmentation for treating comorbid treatment-resistant depression and chronic post-traumatic stress disorder
Authors: Ping Guo, Yu Fang, Ming Feng, Xudong Zhao, Shikai Wang, Mincai Qian, Juanjuan Huang, Huanxin Chen
Journal: Front Psychiatry (2022)
Keywords: prazosin, cognitive function, comorbidity, post-traumatic stress disorder, sleep disturbance, treatment-resistant depression
MeSH terms: Case Reports

Psychological trauma in childhood can lead to post-traumatic disorder (PTSD) with protracted comorbid depression, which responds poorly to conventional antidepressants. Previous studies have shown that prazosin, an α1-adrenergic receptor antagonist, can help eliminate nightmares and improve sleep quality and suicidal ideation in PTSD patients. This case report presents that prazosin had a rapid antidepressant effect in a female adolescent PTSD patient with treatment-resistant depression (TRD). Prazosin improved not only depression symptoms but also sleep quality, suicidal ideation, and cognitive function. Prazosin was well tolerated without obvious adverse effects. Our preliminary study suggests that further clinical trials are needed to determine the efficacy and safety of prazosin in treating PTSD patients with comorbid TRD.
Novel telemetric pressure monitoring in lumbar theca
Authors: Sogha Khawari, Kanza Tariq, Lucia Darie, Eleanor Moncur, Ahmed Toma, Laurence Watkins
Journal: Brain Spine (2022)
Keywords: cerebrospinal fluid pressure, lumboperitoneal shunt, telemetric sensor, telesensor, thecal pressure

Introduction:
There is no previous literature on the use of telemetric sensors (telesensor) in the lumbar theca. We aim to provide novel data on telemetric pressure monitoring of the lumbar theca via lumboperitoneal shunts.
Research question:
Primary outcome is telemetric sensor malfunction of lumboperitoneal shunt. The secondary outcome is post-operative complications.
Materials and methods:
A single centre retrospective case series of patients with telemetric sensor in LP shunt system, between 2015 and 2021, consisting of 5 patients. Review of indications for use, duration of function of telemetric sensor and associated complications.
Results:
There was no procedural complications of LP shunt insertion with telemetric sensor. The patient with highest body weight patient had retraction of distal tubing which required distal resiting 3 times. Four out of five patients had no complications. In all cases, telemetric sensor functioned satisfactorily with no dysfunction. The duration of documentation was 1-40 months. Pressure readings were satisfactorily carried out in variety of positions.
Discussion and conclusion:
This is the first report of telemetric sensor use in the lumbar theca. It can provide a valuable way of measuring cerebrospinal fluid pressures, particularly in patients avoiding cranial surgery. More research is indicated to assess what pressure values would mean clinically.
Clinical findings and genetic expression profiling of three pigmented lesions of the optic nerve
Authors: Manuel A de Alba, Victor M Villegas, Aaron S Gold, Andrea Wildner, Fiona J Ehlies, Azeema Latiff, Timothy G Murray
Journal: Case Rep Ophthalmol Med (2015)

Background. Optic disk melanocytoma is a primary tumor of the optic disk that represents a clinical diagnostic challenge due to its similarities with melanoma. Purpose. The authors present three cases in which genetic expression profiling was used to identify tumor prognosis of optic disk melanocytoma. Case Series. In two cases fine-needle aspiration biopsy was performed to obtain tissue through a transvitreal route into the apex of the tumor while the patient underwent pars plana vitrectomy, laser ablation, phacoemulsification with posterior chamber intraocular lens implantation, and intravitreal triamcinolone acetonide. In the other case the tissue was obtained after definite enucleation. Conclusion. Genetic expression profiling is a useful diagnostic tool for classification and can provide vital information to the ocular oncologist regarding prognosis.
A case of COVID-19 re-infection in Libya
Authors: A Alzedam, A M Bengblya, M J Zeglam, E T Benmassoud, S M Bennji
Journal: Afr J Thorac Crit Care Med (2021)
Keywords: covid-19, libya, reinfection
MeSH terms: Case Reports

Re-infection with SARS-CoV-2 is an active area of research and studying. Here, we present the first documented case of SARS-CoV-2 re-infection in Libya. The patient was a 24-year-old healthy man who initially presented with mild symptoms of generalised fatigue and intermittent episodes of fever for 3 days. During his second episode of COVID-19, he presented with chest tightness and intermittent dry cough. The patient fully recovered from both episodes of COVID-19 without any residual complaints. Since limited cases of SARS-CoV-2 re-infection have been identified, it is probably a rare phenomenon. It is however critical to identify the role of new SARS-CoV-2 variants in the pathogenesis of recurrent COVID-19.
Stent-Assisted Angioplasty in Spontaneous Bilateral Extracranial Internal Carotid Artery Dissection
Authors: Mengshi Liao, Xinran Chen, Hongbing Chen, Ying Wang, JinSheng Zeng, Yuhua Fan
Journal: Front Neurol (2020)
Keywords: ct perfusion, dissection, intervention, stent, therapy
MeSH terms: Case Reports

Internal carotid artery dissection (ICAD) results from a tear in the intima or rupture of the vasa vasorum with bleeding within the media resulting in separation of the vessel wall layers and a false lumen. It may cause arterial stenosis, occlusion, or dissecting pseudoaneurysm. Currently, the treatment of ICAD is controversial, including drug therapy and endovascular stent implantation. Simultaneous spontaneous dissection of bilateral carotid artery is rarely reported. We reported a 39-year-old-man with bilateral ICAD. Although the long-term durability of endovascular stent remains to be determined, for ICAD failed with active drug treatment and combined with hemodynamic impairment, early endovascular stent should be considered.
Resolution of angina pectoris and improvement of the coronary flow reserve after ranolazine treatment in a woman with isolated impaired coronary microcirculation
Authors: Alessandro Santoro, Vincenzo Schiano Lomoriello, Ciro Santoro, Riccardo Muscariello, Maurizio Galderisi
Journal: Case Rep Cardiol (2013)

In a 61-year-old woman with well controlled arterial hypertension, hypercholesterolemia, and smoke and suffering from recurrent angina pectoris despite angiographically normal epicardial coronary vessels and maximal therapy, the replacement of nitrates with novel antiangina drug ranolazine, after 6-month therapy, induced a complete relief of angina and a relevant rising of the transthoracic Doppler-derived coronary flow reserve (CFR). The present clinical case underlines therefore how in patients with chronic ischemic heart disease without epicardial coronary stenosis ranolazine can induce an improvement till the complete solution of the angina symptoms and a substantial increase of CFR as expression of the enhancement of the microvascular coronary function. The improvement of both symptoms and coronary microvascular function is strictly linked to the mechanism of action of the drug. Ranolazine induces in fact a reduction of the intracellular late sodium current that leads to a reduction of the intracellular calcium concentration thus producing a better myocardial diastolic relaxation process which in its turns enhances the myocardial perfusion. The ranolazine acts therefore as a lusitropic drug that improves the diastolic dysfunction and the segmental ischemia thus affecting one of the first steps of the ischemic cascade.
A Subdermal Osteochondroma in a Young Girl
Authors: Heather A Cole, Hernan Correa, Jonathan G Schoenecker
Journal: Case Rep Orthop (2017)
MeSH terms: Case Reports

Osteochondromas are common benign tumors of cartilage and bone. They are usually found as contiguous bone with a cartilage cap at the end of the growth plate of long bones. Similar to structure are extraskeletal osteochondromas. However, unlike typical osteochondromas, extraskeletal osteochondromas are noncontinuous with bone. To our knowledge, all reported extraskeletal osteochondromas have been contained within fascial compartments. Here we present the case of a 5-year-old female who had a slow growing mass of the anterior distal right thigh. Imaging studies revealed an ossified mass extending from dermal layer of the subcutaneous tissue with no connection to the underlying deep fascia. An excisional biopsy was performed and proved to be a subdermal extraskeletal osteochondroma.
A case and literature review of intraocular echinococcus causing bilateral visual loss in a HIV-infected patient
Authors: Kylie Divashnee Konar, Somasundrum Pillay
Journal: SAGE Open Med Case Rep (2022)
Keywords: echinococcosis, south africa, hydatid disease, intraocular, parasitic disease
MeSH terms: Case Reports

Although echinococcosis is a common parasitic disease endemic to Africa, ocular echinococcosis is rare. We present a case of intraocular echinococcosis in a HIV-infected patient. A 38-year-old South African HIV-infected woman presented to a district-level hospital in Kwa-Zulu Natal on 10 March 2020. Her main presenting complaint was that of progressive, painless, bilateral visual loss. A B-ultrasonography scan revealed tractional retinal detachment on the right eye, while the left eye had tractional bands with a 'double-walled' cystic cavity causing retinal traction. A systemic work-up revealed a positive Echinococcus ELISA IgG with a value of 1.3, eosinophilia of 5.70% (0.41 × 109), and elevated C-reactive protein and erythrocyte sedimentation rate of 47 mg/L and 93 mm/hr, respectively. Based on the above clinical, biochemical and ultrasonographical evidence, a diagnosis of ocular echinococcosis was made. Our differential diagnosis includes toxic optic neuropathy, Jarisch-Herxheimer-like reaction secondary to immune reconstitution and necrotizing herpetic retinitis. She was initiated on topical and intravitreal steroids which led to decreased intraocular inflammation and dry maculae. Five months after presentation, her visual acuity remained unchanged with no light perception in both eyes. We conclude that ocular echinococcosis, although rare, can lead to severe visual impairment as there are no known definite treatment modalities for intraocular hydatid disease. Reports on co-infections with HIV and Echinococcus are limited with a potential scope for research.
Recurrent Struma Ovarii Presented with High Levels of Thyroglobulin
Authors: Christiana Oikonomou, Nikol Spathari, Stavroula Doumoulaki, Antonella Koutela, Christos Stagkoglou, Dimitris Keramidaris
Journal: Case Rep Surg (2021)
MeSH terms: Case Reports

Struma ovarii are rare ovarian tumors, of monodermal germ cell origin, containing predominantly thyroid tissue. They are typically benign unilateral pelvic masses. Among the rare cases of malignancy, the most common histological type is that of the papillary carcinoma. A definite preoperative diagnosis of these tumors is difficult to achieve since most imaging findings are generally nonspecific. A rare exception is the case of synchronous abnormal thyroid blood tests where an ovarian teratoma should be highly suspected, especially when no pathology of the thyroid gland coexists. Surgical excision is the mainstay of treatment. Taking into account that struma ovarii are mainly encountered in patients of a childbearing age, a conservative surgical approach is a reasonable option. We present the case of a 56-year-old woman who was diagnosed with both a primary and recurrent struma ovarii while investigating the incidental finding of elevated blood laboratory levels of the thyroglobulin (Tg).