OpenMed/multicare-articles huggingface dataset:
Case Report: Successful Management and Long-Term Follow-Up of Bilateral Ureteral Ligation in a Dog Secondary to Cryptorchid Castration Utilizing Bilateral Ureteral Stents and a Neoureterocystostomy Procedure
Authors: Rebecca Walton, Megan Mickelson, Jean-Sebastien Palerme, April Blong, Meredith 't Hoen
Journal: Front Vet Sci (2022)
Keywords: acute kidney disease, castration, cryptorchid surgery, ureteral, ureteral stents
MeSH terms: Case Reports

Objective:
To report the successful management of the bilateral ureteral obstruction secondary to ureteral ligation during unilateral cryptorchid surgery in a dog with the utilization of bilateral ureteral stent placement and a neoureterocystostomy procedure.
Summary:
A 7-month-old male-castrated Weimaraner weighing 30 kg was presented to a university teaching hospital for evaluation of a 4-day history of lethargy, vomiting, and stranguria following exploratory laparotomy for a left-sided unilateral cryptorchid castration. Based on the concurrent presence of severe azotemia and ultrasonographic findings of bilateral hydronephrosis and hydroureter, the dog was diagnosed with the suspected bilateral ureteral obstruction. The dog underwent a laparotomy which revealed bilateral ureteral ligation which was corrected with a left-sided neoureterocystostomy and right-sided retrograde ureteral stent placement. Subsequent placement of a left-sided ureteral stent due to complications with the neoureterocystostomy site was performed later. Ultimately, both ureteral stents were able to be removed a few months later. The dog was clinically doing well with a baseline creatinine of 1.5 mg/dl (132.6 μmol/L) 532 days following initial bilateral ureteral ligation.
New or unique information provided:
This case report describes the successful long-term management of iatrogenic bilateral ureteral obstructions in a male dog using a combination of bilateral ureteral stents and neoureterocystostomy.
Dual pathology as a cause of proteinuria in the post-transplant period; report of a case
Authors: Rohit Tewari, Satish Mendonca, Vijay Nijhawan
Journal: J Nephropharmacol (2015)
Keywords: post-transplant, proteinuria, recurrent glomerulonephritis, transplant glomerulopathy
MeSH terms: Case Reports

Proteinuria is common after renal transplantation and affects between 35%-45% of patients during the same year as their transplant. We report a case of dual pathology in the renal allograft as a cause of severe proteinuria. A 38-year-old male presented with end-stage renal disease. He underwent live related renal allograft transplant. His immediate post-transplant period was unremarkable. He developed rise in serum creatinine (2.1 mg/dl) 6 months after transplant and was biopsied. He was diagnosed as a case of acute cellular rejection type Ib with suspicion for antibody mediated rejection. He was treated with methylprednisolone to which he showed a good response with return of serum creatinine to 1.6 mg/dl. Subsequently, he developed a nephrotic range proteinuria 6 months after this episode of rejection. Repeat biopsy was performed. He was diagnosed as a case of immune complex mediated glomerulonephritis (GN) (morphologically consistent with pattern of membranoproliferative glomerulonephritis) with chronic humoral rejection in the form of transplant glomerulopathy (TG). IHC for C4d and immunofluorescence studies were instrumental making the diagnosis. He was treated with steroids and rituximab to which he showed a good response with remission of proteinuria. This case highlights the importance of picking up dual pathology in an allograft biopsy to ensure appropriate therapy. The role of C4d and its correct interpretation is further highlighted, especially with regard to pattern (granular versus linear) and location (glomerular capillaries versus peritubular capillaries).
Conversion Therapy for Advanced Pancreatic Cancer: The Case Series and Literature Review
Authors: Mingxing Wang, Yunyun Xu, Min Yang, Dingyi Jiang, Yunwang Chen, Jiahong Jiang, Zheling Chen, Liu Yang, Dongsheng Huang
Journal: Front Pharmacol (2020)
Keywords: advanced pancreatic cancer, chemotherapy, conversion therapy, positron emission tomography-computed tomography (pet-ct), surgery
MeSH terms: Case Reports

Background:
Pancreatic cancer has a high incidence and mortality. Most patients are in an advanced stage at the time of initial diagnosis and cannot be cured by a single surgery. The ASCO clinical practice guideline emphasized the overall management and multidisciplinary comprehensive treatment which put forward the concept of conversion therapy. In this paper, the real-world observation and study were carried out to explore the conversion effect of chemotherapy in patients with advanced pancreatic cancer and their long-term survival.
Methods:
The subjects of this study are advanced pancreatic cancer patients who visited the oncology department of Zhejiang Provincial People's Hospital from 2015 to 2019. Collected and summarized the cases, and selected 5 representative patients for analysis, all of them received standard treatment (FOLFIRINOX, AS, AG, or GS). The progress, clinical evaluation, adverse reactions, and prognosis of these patients after conversion therapy were analyzed and discussed in conjunction with relevant literature.
Results:
Five patients with advanced pancreatic cancer received conversion therapy with an average survival time of 29.8 months, two of them received surgical treatment, and postoperative evaluations were pathological complete response (pCR). The tolerance of chemotherapy was good in five patients, and no serious adverse reactions of grade 3 or 4 occurred.
Conclusion:
Conversion therapy for patients with advanced pancreatic cancer strives for surgical opportunities of radical resection, prolongs survival and improves quality of life.
Completion Pancreaticoduodenectomy for a Second Primary Pancreatic Cancer: A Case Report
Authors: Jeffrey M Hardacre
Journal: Case Rep Pancreat Cancer (2016)
Keywords: completion pancreatectomy, recurrent pancreatic cancer
MeSH terms: Case Reports

Background: Recurrent pancreatic cancer may represent a true local recurrence or a second intrapancreatic primary. Resection of recurrent pancreatic cancer is uncommon. Case Presentation: A 68-year-old woman underwent a distal pancreatectomy/splenectomy for pancreatic adenocarcinoma after presenting with acute pancreatitis. She received 6 months of adjuvant gemcitabine. Nearly 5 years later, she presented with acute pancreatitis. Endoscopic ultrasonography suggested malignant degeneration of an uncinate intraductal papillary mucinous neoplasm (IPMN), but the cytology was negative. She subsequently underwent a completion pancreaticoduodenectomy for what proved to be a second pancreatic adenocarcinoma. Conclusion: Although uncommon, repeat resection for a second pancreatic cancer may be appropriate in select patients. Careful attention to the remnant pancreas must be maintained on surveillance imaging.
Abulia following penetrating brain injury during endoscopic sinus surgery with disruption of the anterior cingulate circuit: case report
Authors: Alexander A Grunsfeld, Ivan S Login
Journal: BMC Neurol (2006)
MeSH terms: Akinetic Mutism / etiology, Basal Ganglia / injuries, Endoscopy / adverse effects, Gyrus Cinguli / pathology, Head Injuries, Penetrating / complications, Case Reports, Basal Ganglia / pathology, Female, Functional Laterality, Humans, Magnetic Resonance Imaging, Middle Aged, Neural Pathways / injuries, Neural Pathways / pathology, Paranasal Sinuses, Sinusitis / surgery

Background:
It is common knowledge that the frontal lobes mediate complex human behavior and that damage to these regions can cause executive dysfunction, apathy, disinhibition and personality changes. However, it is less well known that subcortical structures such as the caudate and thalamus are part of functionally segregated fronto-subcortical circuits, that can also alter behavior after injury. CASE PRESENTATION We present a 57 year old woman who suffered penetrating brain injury during endoscopic sinus surgery causing right basal ganglia injury which resulted in an abulic syndrome.
Conclusion:
Abulia does not result solely from cortical injury but can occur after disruption anywhere in the anterior cingulate circuit--in the case of our patient, most prominently at the right caudate.
Surgical treatment of severe thoracic kyphosis and neurological deficit in a patient with Gorham-Stout syndrome: A case report and literature review
Authors: Hanwen Zhang, Chaofan Han, Daming Pang, Hai Yong, Jincai Yang, Peng Yin, Lijin Zhou
Journal: Front Surg (2022)
Keywords: vcrs osteotomy, chylothorax thoracic kyphosis, gorham-stout syndrome, halo-pelvic traction, spine deformity
MeSH terms: Case Reports

Background:
Gorham-Stout syndrome is an uncommon condition with a varied clinical presentation and unclear cause that is characterised by a proliferation of lymphatic capillaries and severe regional osteolysis. Spinal and visceral involvement increases the syndrome's morbidity and mortality rates. Here, we report about a male patient with Gorham's disease who developed local kyphosis and neurological disorders due to massive osteolysis.
Case presentation:
A 13-year-old male patient presented with progressive kyphosis and massive osteolysis of the thoracic vertebrae. Halo-pelvic traction and vertebral column resection osteotomy were performed to reconstruct the spine and prevent disease progression. The entire lesion was resected, and an artificial vertebra filled with allograft bone was used to achieve temporary stability. Although the patient presented with chylothorax following surgery, which required thoracic drainage, the patient did achieve a satisfying outcome.
Conclusions:
Limited by the number of GSS cases with spinal involvement and chylothorax manifestations, halo-pelvic distraction as a preoperative preparation and vertebral column resection osteotomy provide a novel avenue for managing this disease.
Posterior Mediastinal and Cutaneous Back Hemangiomas in Infants: A New Association
Authors: Amr AbdelHamid AbouZeid, Shaimaa Abdelsattar Mohammad, Heba Gomaa Aly, Iman Ahmed Ragab
Journal: European J Pediatr Surg Rep (2021)
Keywords: hemangioma, magnetic resonance imaging, paravertebral, vascular tumors
MeSH terms: Case Reports

Infantile hemangiomas (IHs) are common vascular tumors. In most cases, a benign course with favorable outcome can be anticipated. IH typically present as cutaneous lesions either with a localized or diffuse segmental distribution. Segmental hemangiomas in the face may be associated with brain and cardiac anomalies (PHACES syndrome), whereas airway involvement has been reported to be associated with hemangiomas in the "beard" area. Multiple cutaneous hemangiomas may be associated with visceral hemangiomas (commonly in the liver). In this report, we present a new association where deep paravertebral hemangiomatous lesions were observed to be associated with cutaneous back hemangiomas in two consecutive cases.
Detection of Hereditary 1,25-Hydroxyvitamin D-Resistant Rickets Caused by Uniparental Disomy of Chromosome 12 Using Genome-Wide Single Nucleotide Polymorphism Array
Authors: Mayuko Tamura, Tsuyoshi Isojima, Minae Kawashima, Hideki Yoshida, Keiko Yamamoto, Taichi Kitaoka, Noriyuki Namba, Akira Oka, Keiichi Ozono, Katsushi Tokunaga, Sachiko Kitanaka
Journal: PLoS One (2015)
MeSH terms: Chromosomes, Human, Pair 12, Polymorphism, Single Nucleotide, Rickets, Hypophosphatemic / diagnosis, Rickets, Hypophosphatemic / genetics, Uniparental Disomy / genetics, Vitamin D / analogs & derivatives, Case Reports, Research Support, Non-U.S. Gov't, Administration, Oral, Alleles, Alopecia / genetics, Body Height, Calcium / administration & dosage, Child, Preschool, Dietary Supplements, Female, Genome, Human, Growth Disorders / genetics, Heterozygote, Homozygote, Humans, Hydroxycholecalciferols / administration & dosage, Mutation, Vitamin D / metabolism, Hydroxycholecalciferols, Vitamin D, 1,25-dihydroxyvitamin D, Calcium, alfacalcidol

Context:
Hereditary 1,25-dihydroxyvitamin D-resistant rickets (HVDRR) is an autosomal recessive disease caused by biallelic mutations in the vitamin D receptor (VDR) gene. No patients have been reported with uniparental disomy (UPD).
Objective:
Using genome-wide single nucleotide polymorphism (SNP) array to confirm whether HVDRR was caused by UPD of chromosome 12.
Materials and methods:
A 2-year-old girl with alopecia and short stature and without any family history of consanguinity was diagnosed with HVDRR by typical laboratory data findings and clinical features of rickets. Sequence analysis of VDR was performed, and the origin of the homozygous mutation was investigated by target SNP sequencing, short tandem repeat analysis, and genome-wide SNP array.
Results:
The patient had a homozygous p.Arg73Ter nonsense mutation. Her mother was heterozygous for the mutation, but her father was negative. We excluded gross deletion of the father's allele or paternal discordance. Genome-wide SNP array of the family (the patient and her parents) showed complete maternal isodisomy of chromosome 12. She was successfully treated with high-dose oral calcium.
Conclusions:
This is the first report of HVDRR caused by UPD, and the third case of complete UPD of chromosome 12, in the published literature. Genome-wide SNP array was useful for detecting isodisomy and the parental origin of the allele. Comprehensive examination of the homozygous state is essential for accurate genetic counseling of recurrence risk and appropriate monitoring for other chromosome 12 related disorders. Furthermore, oral calcium therapy was effective as an initial treatment for rickets in this instance.
Hemolytic Anemia and Reactive Thrombocytosis Associated With Cefoperazone/Sulbactam
Authors: Ling Zhou, Jianan Bao, Jingjing Ma
Journal: Front Pharmacol (2019)
Keywords: adverse reaction, cefoperazone/sulbactam, immune hemolytic anemia, probable, reactive thrombocytosis
MeSH terms: Case Reports

Background: Cefoperazone/sulbactam is a broad-spectrum antibacterial agent. Drug-induced immune hemolytic anemia is a rare but serious condition, and reactive thrombocytosis is caused by processes extrinsic to the megakaryocyte. Limited data are available for cefoperazone/sulbactam-associated hemolytic anemia and reactive thrombocytosis. Case presentation: We report the case of a 60-year-old woman undergoing surgical excision of the left atrial myxoma, who presented with hemolytic anemia and thrombocytosis following cefoperazone/sulbactam administration for lung infection. The duration of cefoperazone/sulbactam therapy was 8 days. Blood analysis showed markedly decreased hemoglobin, hematocrit, and red blood cell levels, with elevated lactate dehydrogenase, indirect bilirubin, platelets, and reticulocytes. Furthermore, the direct antiglobulin test was positive for anti-C3 and a diagnosis of hemolytic anemia and reactive thrombocytosis was made. Then, cefoperazone/sulbactam was discontinued and red blood cell transfusion was performed for 3 days. After 1 week, the patient's condition improved, and she was discharged. Conclusion: This is the first suspected case report of immune hemolytic anemia and reactive thrombocytosis related to cefoperazone/sulbactam. Caution should be taken for this reaction in patients undergoing cefoperazone/sulbactam therapy.
Monoclonal Gammopathy of Renal Significance with Progression to Multiple Myeloma in a Patient with ASIA-MO Syndrome
Authors: David Alejandro Vargas Gutiérrez, Karina Ivonne Arias Callejas, Edwin Pavel Palacios Ruiz, Priscila Joseline Pérez Vinueza, Juan Diego Muñoz Vega, Ana Karen G Mejía Geraldo, Ingrid Salinas Zaldívar
Journal: Case Rep Hematol (2022)
MeSH terms: Case Reports

Background:
Autoimmune/inflammatory syndrome induced by adjuvants is a disease associated with an unregulated hyperactivity of the immune system and may also be associated with a high frequency of hematologic malignancies. Report. This is a case of a female with ASIA-MO syndrome secondary to infiltration of mineral oil for aesthetic purposes and presented with multiple episodes of urolithiasis resulting in renal impairment of her left kidney confirmed by scintigraphy and ending in unilateral nephrectomy. Retrospective renal piece analysis confirmed tubulointerstitial infiltration with light chains and plasma cells. Paraffin fixation prevented subsequent immunofluorescence analysis for better follow-up of the patient.
Conclusion:
The presence of positive immunofixation kappa chains explained the sudden deterioration of renal function with monoclonal gammopathy of renal significance which concluded in an association between diseases, such as multiple light chain myeloma, as a final diagnosis.
First report of the cystic fibrosis transmembrane conductance regulator mutation c.1521_1523delCTT (p. Phe508del) in two Qatari patients with cystic fibrosis
Authors: Atqah AbdulWahab, Amal AlNaimi, Basel Habra, Ibrahim Janahi
Journal: Qatar Med J (2021)
Keywords: qatar, cystic fibrosis, p phe508del mutation
MeSH terms: Case Reports

We report two cases of Qatari children with cystic fibrosis (CF) from different families presenting the homozygous CFTR 1521_1523delCTT (p. Phe508del) mutation with classic CF phenotypes. This gene mutation is considered the second CF mutation identified in Qatar. Herein, we review the frequency and distribution of this mutation in Arab countries.
A Case of Malignant Melanoma of the Uterine Cervix with Disseminated Metastases throughout the Vaginal Wall
Authors: Tomoko Noguchi, Nami Ota, Yasushi Mabuchi, Shigetaka Yagi, Sawako Minami, Hisako Okuhira, Yuki Yamamoto, Yasushi Nakamura, Kazuhiko Ino
Journal: Case Rep Obstet Gynecol (2017)
MeSH terms: Case Reports

Malignant melanoma (MM) in the female genital tract accounts for less than 2% of all melanomas, and the vast majority associated occur in the vulva and vagina. Primary MM of the uterine cervix is extremely rare and its prognosis is very poor. We report a case of primary MM of the cervix with dissemination throughout the vaginal wall. A 66-year-old woman presented with postmenopausal bleeding. Gynecologic examination demonstrated a 2 cm polypoid blackish-pigmented tumor on the cervix with multiple small blackish-pigmented lesions throughout the vaginal wall. Cervical Pap smear cytology showed malignant melanoma. MRI and PET/CT did not detect any distant or lymph node metastases. She underwent radical hysterectomy, pelvic lymphadenectomy, and total vaginectomy. The pathological diagnosis was FIGO stage IIIA primary cervical MM. She received adjuvant chemotherapy with 6 courses of dacarbazine, but 6 months later, multiple lung metastases were detected. Despite 4 courses of anti-PD-1 antibody (nivolumab) treatment, she died of the disease 13 months after surgery.
An unusual case of giant cell myocarditis missed in a Heartmate-2 left ventricle apical-wedge section: a case report and review of the literature
Authors: Kim Anderson, Michel Carrier, Philippe Romeo, Guy B Pelletier, Mark Liszkowski, Normand Racine, Michel White, Anique Ducharme
Journal: J Cardiothorac Surg (2013)
MeSH terms: Giant Cells / pathology, Heart Transplantation, Heart Ventricles / pathology, Myocarditis / pathology, Case Reports, Research Support, Non-U.S. Gov't, Adult, Female, Heart Ventricles / cytology, Heart-Assist Devices, Humans, Lymphoma, B-Cell / drug therapy, Lymphoma, B-Cell / pathology, Myocarditis / surgery

Herein we present a case of fulminant myocarditis in a woman previously treated for B-cell lymphoma. While the clinical context was suggestive of adriamycin-induced cardiomyopathy, the initial pathology of the Heartmate-2 apical core showed lymphocytic myocarditis. After 8 months of stability, the patient presented with progressive heart failure and recurrent ventricular arrhythmias. An endomyocardial biopsy revealed findings typical of giant cell myocarditis (GCM); poor response to immunosuppressive therapy and marked hemodynamic instability led to urgent transplantation. To our knowledge, this is the first reported case of GCM following an acute lymphocytic myocarditis and the second GCM case associated with B-cell lymphoma.
Emergent dolutegravir resistance in integrase-naïve, treatment experienced patients from Zimbabwe
Authors: Linda A Mandikiyana Chirimuta, Margaret J Pascoe, Sara Lowe
Journal: South Afr J HIV Med (2022)
Keywords: hiv, hiv drug resistance, antiretroviral treatment, dolutegravir, integrase strand inhibitor
MeSH terms: Case Reports

We report two cases of dolutegravir (DTG) resistance in highly treatment experienced patients. Monitoring for treatment failure and adherence support is important in highly treatment experienced patients taking DTG.
What this study adds:
Dolutegravir is the mainstay of HIV treatment programmes and emergence of drug resistance to DTG is of public health relevance.
Recurrent Hyperkalemia During General Anesthesia in a Dog
Authors: Carissa W Tong, Anusha Balakrishnan, Rachel Matusow Wynne
Journal: Front Vet Sci (2020)
Keywords: anesthesia, canine, hyperkalemia, propofol, propofol infusion syndrome
MeSH terms: Case Reports

Objective: To describe the development of recurrent hyperkalemia in a dog that underwent general anesthesia at two different hospitals within a month. The definitive underlying cause of the hyperkalemia remains unknown. Case summary: A 11 year-old male neutered Rottweiler underwent general anesthesia on two separate occasions at two different hospitals for ophthalmic surgery within a month and developed marked hyperkalemia on each occasion. The patient received similar drug protocols in both instances, including propofol, midazolam, non-depolarizing neuromuscular blocking agents, and isoflurane inhalant anesthetic. The patient showed ECG changes consistent with hyperkalemia during the first anesthetic event, but not the second. No underlying cause of hyperkalemia was definitively identified. The patient responded to standard therapy for hyperkalemia on both occasions and serum potassium levels returned to normal. The patient was discharged from the hospital without further complications and post-operative rechecks showed persistently normal serum potassium levels. New or unique information provided: Considering that there is a relationship between the development of severe hyperkalemia and propofol administration in human patients, it is possible that such a relationship exists in veterinary patients. However, numerous other diseases and medications can also lead to peri-operative hyperkalemia. Veterinary professionals should be aware that hyperkalemia can develop intra-operatively and remains be an important differential diagnosis in bradycardic patients under anesthesia that are not responding to traditional therapies.
A Case of Female Acute Urinary Retention Presenting to the ED
Authors: Kylen Swartzberg, Ahmed Adam, Feroza Motara, Abdullah E Laher
Journal: Case Rep Emerg Med (2017)
MeSH terms: Case Reports

Introduction:
Acute urinary retention is a rare occurrence in women necessitating further investigation. Potential underlying causes may be broadly classified into obstructive, neurological, pharmacological, and psychogenic categories.
Case:
A 36-year-old nulliparous female presented to the Emergency Department with a two-day history of acute urinary retention. Point-of-care ultrasonography and CT scan imaging confirmed the presence of a large uterine mass causing compression of the bladder. The acute retention was relieved with urethral catheterization. A Uterine leiomyoma was confirmed on histology after hysterectomy.
Discussion:
Once the acute urinary retention has been relieved by insertion of a urethral catheter, the underlying cause of the obstruction must be determined. Although uterine leiomyoma is a fairly common finding in the general population, it is an extremely rare cause of acute urinary retention in women with just a handful of reported cases in the literature.