OpenMed/multicare-articles huggingface dataset:
Hybrid fixation with ESIN for both bone forearm fractures in adults: A case report and literature review
Authors: Xiaodong Bai, Zhenyu Liu, Wentao Chen, Baojun Wang
Journal: Front Surg (2022)
Keywords: case report, elastic-stable intramedullary nailing, forearm fractures, hybrid fixation, open reduction and internal fixation
MeSH terms: Case Reports

Objective:
Both bone forearm fractures are common in children and rare in adults. The main surgical treatment is open reduction and internal fixation (ORIF) with plate, while the hybrid fixation of elastic-stable intramedullary nailing (ESIN) and the plate has been rarely reported before.
Case report:
We report a case of a 29-year-old male patient with both bone forearm fractures. Temporarily closed reduction and plaster external fixation were performed in the emergency room, and the patient was admitted to the orthopedic trauma ward for surgery. The patient underwent open reduction and plate fixation of the ulna and closed reduction and ESIN fixation of the radius. The fractures healing was satisfactory and the internal fixation was removed 12 months postoperatively.
Conclusion:
The hybrid fixation of ESIN and plate is an effective option for both bone forearm fractures in adults.
Clinical and biological heterogeneity of multisystem inflammatory syndrome in adults following SARS-CoV-2 infection: a case series
Authors: Kaia E Barth, Natasha Spottiswoode, Charlotte Hurabielle, Lakshmi Subbaraj, COMET Consortium, Carolyn S Calfee, Michael A Matthay, Sarah French, Andrew Connolly, Stephen M Hewitt, Kevin M Vannella, Christopher Barnett, Charles R Langelier, Sarah Patterson
Journal: Front Med (Lausanne) (2023)
Keywords: covid-19, dka, mis-a, sars-cov-2, multisystem inflammatory syndrome, myocarditis
MeSH terms: Case Reports

Importance:
Multisystem inflammatory syndrome in adults (MIS-A) is a poorly understood complication of SARS-CoV-2 infection with significant morbidity and mortality.
Objective:
Identify clinical, immunological, and histopathologic features of MIS-A to improve understanding of the pathophysiology and approach to treatment.
Design:
Three cases of MIS-A following SARS-CoV-2 infection were clinically identified between October 2021 - March 2022 using the U.S. Centers for Disease Control and Prevention diagnostic criteria. Clinical, laboratory, imaging, and tissue data were assessed.
Findings:
All three patients developed acute onset cardiogenic shock and demonstrated elevated inflammatory biomarkers at the time of hospital admission that resolved over time. One case co-occurred with new onset Type 1 diabetes and sepsis. Retrospective analysis of myocardial tissue from one case identified SARS-CoV-2 RNA. All three patients fully recovered with standard of care interventions plus immunomodulatory therapy that included intravenous immunoglobulin, corticosteroids, and in two cases, anakinra.
Conclusion:
MIS-A is a severe post-acute sequela of COVID-19 characterized by systemic elevation of inflammatory biomarkers. In this series of three cases, we find that although clinical courses and co-existent diseases vary, even severe presentations have potential for full recovery with prompt recognition and treatment. In addition to cardiogenic shock, glucose intolerance, unmasking of autoimmune disease, and sepsis can be features of MIS-A, and SARS-CoV-2 myocarditis can lead to a similar clinical syndrome.
Second trimester abortion as a cause of maternal death: a case report
Authors: Sümeyra Nergiz Avcioglu, Sündüz Özlem Altinkaya, Mert Küçük, Emre Zafer, Selda Demircan Sezer, Hasan Yüksel
Journal: Pan Afr Med J (2015)
Keywords: second trimester, maternal death, spontaneous abortion
MeSH terms: Abortion, Spontaneous, Heart Arrest / etiology, Maternal Death / etiology, Case Reports, Adult, Female, Humans, Laparotomy / methods, Pregnancy, Pregnancy Trimester, Second, Time Factors

Each year, an estimated 529 000 maternal deaths occur worldwide. In literature, it is known that maternal mortality can occur during pregnancy, peripartum and also in postpartum period. Although very rare, maternal deaths may occur after spontaneous abortion. In present case, 37 year old G5P4 (Caesarean Section) women was admitted to Adnan Menderes University, Obstetrics and Gynecology clinic with diagnosis of missed abortion at 18 weeks' gestation. She had been hospitalized in the public maternity hospital for five days due to abortus incipience and prolapse of amnion membranes but had no contractions. Fetal heart beats ceased at the second day of hospitalization. Medically induced abortion was recommended but not accepted by the patient. At the fifth day of hospitalization, she was referred to our clinic due to deterioration of general health condition, low blood pressure and tachycardia. In emergency department, it was determined that she was not oriented, had confusion, had blood pressure of 49/25 mmHg and tachycardia. In ultrasonographic examination, 18 week in utero ex fetus was determined and there was free fluid in abdominopelvic cavity. The free fluid was suspected to be amniotic fluid due to rupture of uterus. Laparotomy was performed, no uterine rupture, hematoma or atony was observed. However during laparotomy, a very bad smelling odor, might be due to septicemia, was felt in the operation room. Cardiac arrest occurred during that operation. In autopsy report, it was concluded that maternal death was because of remaining of inutero ex fetus for a long time. In conclusion, although very rare, maternal deaths after spontaneous abortion may occur. Because spontaneous abortion is a common outcome of pregnancy, continued careful, strict monitoring and immediate treatment of especially second trimester spontaneous abortion is recommended to prevent related, disappointing, unexpected maternal deaths.
Can spontaneous pneumothorax be resolved in COVID-19 without hospital care? A case report
Authors: Narges Tamaskani, Mahmoud Khandashpour, Somayeh Livani
Journal: Caspian J Intern Med (2021)
Keywords: covid-19, ct scan, iran, pneumothorax, radiology
MeSH terms: Case Reports

Background:
We encountered the novel coronavirus infection as a pandemic in 2020. The infection started in Wuhan, China, and spread rapidly all over the world. CT scan has been used as an important diagnostic method in the detection of suspicious patients. One of the uncommon complications of coronavirus disease 2019 (COVID-19) is pneumothorax.
Case presentation:
A 47-year-old smoker male with COVID-19 diagnosis, good general condition and no respiratory complaint, complicated by pneumothorax. He refused hospitalization. After educating him about the red flags and quarantine protocols, he continued treatment at home .Cap amoxicillin/clavulanic acid 625mg was prescribed for one week. A follow-up CT represented only small involvement of lungs. Pneumothorax was resolved spontaneously without any medical intervention and hospitalization. O2 saturation was in normal range an there was no dry cough anymore.
Conclusion:
According to our clinical experience, pneumothorax is resolved spontaneously in a COVID-19 case. Considering general status and hemodynamic stability, it is suggested to reduce invasive interventions in COVID-19 cases with pneumothorax.
Dilatation of the great arteries in an infant with marfan syndrome and ventricular septal defect
Authors: L Rozendaal, N A Blom, Y Hilhorst-Hofstee, A D J Ten Harkel
Journal: Case Rep Med (2011)
MeSH terms: Case Reports

We describe an infant presenting with contractures of the fingers, a large ventricular septal defect (VSD), and severe pulmonary artery dilatation. He had clinical and echocardiographic features of both neonatal or infantile Marfan syndrome (MFS) and congenital contractural arachnodactyly. After surgical VSD closure, the aortic root developed progressive dilatation while the size of pulmonary artery returned to normal limits. Eventually the diagnosis of MFS was confirmed by DNA analysis.
Genomic instability in a chronic lymphocytic leukemia patient with mono-allelic deletion of the DLEU and RB1 genes
Authors: María Paulina Nava-Rodríguez, Martín Daniel Domínguez-Cruz, Lilia Beatriz Aguilar-López, César Borjas-Gutiérrez, María Teresa Magaña-Torres, Juan Ramón González-García
Journal: Mol Cytogenet (2019)
Keywords: 13q14 deletion, dleu and rb1 gene loss, chronic lymphocytic leukemia, genomic instability
MeSH terms: Case Reports

Background:
The most frequent cytogenetic abnormality detected in chronic lymphocytic leukemia (CLL) patients is the presence of a deletion within the chromosome band 13q14. Deletions can be heterogeneous in size, generally encompassing the DLEU1 and DLEU2 genes (minimal deleted region), but at times also including the RB1 gene. The latter, larger type of deletions are associated with worse prognosis.Genomic instability is a characteristic of most cancers and it has been observed in CLL patients mainly associated with telomere shortening.
Case presentation:
Cytogenetic and fluorescence in situ hybridization studies of a CLL patient showed a chromosomal translocation t(12;13)(q15;q14), a mono-allelic 13q14 deletion encompassing both the DLEU and RB1 genes, and genomic instability manifested as chromosomal breaks, telomeric associations, binucleated cells, nucleoplasmic bridges, and micronucleated cells.In conclusion, our CLL patient showed genomic instability in conjunction with a 13q14 deletion of approximately 2.6 megabase pair involving the DLEU and RB1 genes, as well as other genes with potential for producing genomic instability due to haploinsufficiency.
Sarcomatoid Variant of Urothelial Carcinoma of the Renal Pelvis with Inferior Vena Cava Tumour Thrombus: A Case Report and Literature Review
Authors: Sameera Rashid, Mohammed Akhtar
Journal: Case Rep Pathol (2018)
MeSH terms: Case Reports

Sarcomatoid variant of urothelial carcinoma (SVUC) of the renal pelvis is a rare entity. To the best of our knowledge, around 25 cases of this neoplasm have been reported in the literature to date, most of which were of high stage. The inferior vena cava tumour thrombus, which is a hallmark of renal cell carcinoma (RCC), may rarely be found in urothelial carcinoma of renal pelvis. In this report, a case of SVUC associated with tumour extension to inferior vena cava is documented. This association has been encountered in only one previously reported case. The possibility of urothelial carcinoma of the renal pelvis should therefore be included in the differential diagnosis of tumour thrombus of the inferior vena cava.
Traumatic Foreign Body into the Face: Case Report and Literature Review
Authors: Maysa Nogueira de Barros Melo, Lidyane Nunes Pantoja, Sara Juliana de Abreu de Vasconcellos, Viviane Almeida Sarmento, Christiano Sampaio Queiroz
Journal: Case Rep Dent (2017)
MeSH terms: Case Reports

This paper describes a case of mouth opening limitation, secondary to a facial trauma by cutting-piercing instrument, whose fragments had not been diagnosed in the immediate posttrauma care. Description of an unusual surgical maneuver and a literature review are presented.
Staged concept for treatment of severe postsaphenectomy wound infection
Authors: Thomas Schroeter, Sreekumar Subramanian, Michael A Borger, Friedrich W Mohr
Journal: Case Rep Med (2011)
MeSH terms: Case Reports

The saphenous vein remains the most commonly used conduit in coronary artery bypass surgery. Vein harvest is a critical component with significant morbidity associated with leg wounds from open technique. Occurring complications are hematoma, postoperative pain, skin changes, neuropathy, and septic or nonseptic wound complications. Within the context of a recent case, we present our approach to postsaphenectomy wound management.
Osteoid osteoma of the lunatum mimicking Kienböck's disease
Authors: Mehmet Derviş Güner, Haldun Onuralp Kamburoğlu, Umut Bektaş, Şadan Ay
Journal: Case Reports Plast Surg Hand Surg (2015)
Keywords: hand, osteoid osteoma, tumor, wrist
MeSH terms: Case Reports

Hands, especially lunatum, are involved very rarely with osteoid osteoma. This report presents an osteoid osteoma of the lunatum, which was previously misdiagnosed as Kienböck's disease and had undergone surgery. Magnetic resonance imaging may lead the clinician to misdiagnose because of the excessive bone edema around the carpus. The operation should be planned according to radiography and computed tomography findings.
Postextractive Alveolar Ridge Preservation Using L-PRF: Clinical and Histological Evaluation
Authors: Giorgio Serafini, Marco Lollobrigida, Lorenzo Fortunato, Giulia Mazzucchi, Luca Lamazza, Dario Di Nardo, Iole Vozza, Mara Riminucci, Alberto De Biase
Journal: Case Rep Dent (2020)
MeSH terms: Case Reports

Leukocyte- and platelet-rich fibrin (L-PRF) is an autologous platelet concentrate rich in growth factors and plasma proteins, obtained by centrifugation of patient whole blood, and widely used in oral surgery. This report describes a case of alveolar ridge preservation with L-PRF membranes. Postextractive alveolar healing was then assessed through a histologic and histomorphometric analysis. A patient requiring tooth extraction and subsequent implant rehabilitation was treated with simple extraction and socket filling with L-PRF membranes. Implant placement was performed at 3 months, and a bone biopsy was obtained for histomorphometric analysis. Histological examination of the grafted sites showed that the use of L-PRF could achieve good results in terms of bone dimension and quality and soft tissue healing. The results of this study support the use of L-PRF membranes to preserve hard and soft tissues after tooth extraction.
Primary sternal tumour resection and reconstruction with LARS mesh-bone cement sandwich by 3D-printing: Case reports
Authors: He Zhang, Bo Hou, Tienan Xia, Lu Ji, Jiatong Li, Ting Chen, Guanning Shang
Journal: Front Bioeng Biotechnol (2023)
Keywords: 3d-printing, lars, bone cement, case reports, reconstruction, sternal tumour
MeSH terms: Case Reports

Background: There are many reconstruction methods after sternal tumor resection, but the method that LARS mesh combines with bone-cement has not been reported. Case report: A 54-year-old female patient and a 55-year-old male patient admitted to our department all presented with sternum masses, but neither presented with respiratory disorders. In women with limited manubrium sternum lesions, we resected the manubrium sternum completely. In men with sternal lesions, we removed part of the sternum and part of the sternocostal joint. The patients recovered well after surgery, and there were no respiratory complications and no tumor recurrence during the 1-year follow-up respectively. Conclusion: We report two cases of sternal defect repair using LARS mesh combined with bone cement. This method is safe and stable, and can achieve satisfactory results.
Successful treatment of concomitant alopecia universalis and Crohn's disease with upadacitinib: A case report
Authors: Leah A Johnston, Cathy Lu, Susan M Poelman
Journal: SAGE Open Med Case Rep (2023)
Keywords: alopecia areata, crohn’s disease, jak inhibitor, hair loss, inflammatory bowel disease, upadacitinib
MeSH terms: Case Reports

Alopecia areata is a non-scarring, autoimmune hair loss disorder that is associated with inflammatory bowel disease. Alopecia areata and inflammatory bowel disease may have a common pathogenic mechanism that involves the Janus kinase/STAT pathway. In addition, there are previous case reports of patients who developed alopecia areata while on biologic therapies for inflammatory bowel disease. JAK1 inhibitors are currently undergoing investigation as potential therapies for Crohn's disease. Upadacitinib, an oral JAK1 inhibitor, has demonstrated efficacy in treating Crohn's disease during phase III clinical trials. In this case report, we present a 23-year-old man with Crohn's disease who previously developed alopecia areata while on adalimumab. He had near-complete resolution of his alopecia universalis after 7 months of treatment with upadacitinib while on concurrent ustekinumab for Crohn's disease, which he had been taking for 16 months prior to starting upadacitinib. Upadacitinib may be a beneficial therapy for treating concomitant alopecia areata and Crohn's disease.
Low-Grade Adenosquamous Carcinoma of the Axilla of Breast Origin in a Male: A Case Report and Literature Review
Authors: Xingqiang Yan, Fanshuang Zhu, Qiupeng Wang, Lijie Chen, Yixing Zhou, Zenggui Wu, Linhang Mei, Zhaosheng Ma, Binbin Cui, Feilin Cao
Journal: Front Oncol (2020)
Keywords: breast, cancer, estrogen receptor, low-grade adenosquamous carcinoma, metaplastic carcinoma
MeSH terms: Case Reports

Low-grade adenosquamous carcinoma (LGASC) is a rare invasive tumor that occurs in breast parenchyma. It has previously only been reported in females. Herein, we describe the case of a 52-year-old male who presented with a palpable mass in his right axilla that he reported had been present for 20-years. This is the first report of a male patient with LGASC. Core needle biopsy pathology revealed a benign mass of mammary origin, but its type was initially misdiagnosed. It was only correctly identified via postoperative pathology after local excision, which indicated that the mass exhibited the typical pathological characteristics of LGASC. Immunohistochemical analysis revealed positive expression of estrogen receptor, which was inconsistent with the typical "triple-negative" immunophenotype of LGASC. After resection of the mass the patient was advised to participate in regular outpatient follow-up. In conclusion, LGASC should be considered in male patients with a mass lesion in their breast or axilla, even when core needle biopsy indicates a benign mass of breast origin. One-stage local resection is recommended for the treatment of male patients with LGASC, but it is crucial to ensure that the margins are negative and postoperative adjuvant radiotherapy is not recommended.
Medial Pelvic Migration of the Lag Screw after Intramedullary Nailing for Trochanteric Femoral Fracture
Authors: Kohei Kuroshima, Koichi Kasahara, Shinsuke Kihara, Yoshifumi Harada, Masatoshi Sumi
Journal: Case Rep Orthop (2021)
MeSH terms: Case Reports

Internal fixation with intramedullary nails has gained popularity for the treatment of trochanteric femoral fractures, which are common injuries in older individuals. The most common complications are lag screws cut-out from the femoral head and femoral fracture at the distal tip of the nail. Herein, we report a rare complication of postoperative medial pelvic migration of the lag screw with no trauma. The patient was subsequently treated by lag screw removal via laparoscopy. This case suggests that optimal fracture reduction, adequate position of the lag screw, and careful attention to set screw insertion are important to prevent complications. Additionally, laparoscopic surgery might be able to remove the lag screw more safely than removal from the femoral side.
A Catheter-Related Bloodstream Infection by Brevibacterium casei in a Child with Acute Myeloid Leukemia: Case Report and Literature Review
Authors: Fumihiro Ochi, Hisamichi Tauchi, Kyoko Moritani, Shinobu Murakami, Hitoshi Miyamoto, Mayo Ueda, Kozo Nagai, Minenori Eguchi-Ishimae, Mariko Eguchi
Journal: Case Rep Pediatr (2021)
MeSH terms: Case Reports

The most common organisms isolated from pediatric catheter-related bloodstream infections (CRBSIs) are Gram-positive cocci, such as coagulase-negative staphylococci and Staphylococcus aureus. There are few formal reports of Brevibacterium casei infection and even fewer reports of CRBSI due to this Gram-positive rod. Here we report the first case of CRBSI due to B. casei in an 8-year-old girl with acute myeloid leukemia in Japan. The isolate exhibited decreased susceptibility to ß-lactam antibiotics. Antimicrobial therapy with meropenem and vancomycin, in addition to the removal of central venous catheter line, consequently led to a significant clinical improvement of the patient's symptoms. A literature review found available clinical courses in 16 cases (4 pediatric cases including our case) of B. casei infection. Our case and those in literature suggested that B. casei infection often occurs in patients with indwelling central venous catheters; the literature review further suggested that removal of central venous catheters is required in most cases. Special attention should be paid to the detection of opportunistic infections due to Brevibacterium spp. in immunocompromized children who are using a central venous catheter.
Incontinentia pigmenti in a child with suspected retinoblastoma
Authors: Stephanie J Weiss, Archana Srinivasan, Michael A Klufas, Carol L Shields
Journal: Int J Retina Vitreous (2017)
Keywords: bloch–sulzberger syndrome, eye, incontinentia pigmenti, pseudoretinoblastoma, retinal detachment, retinoblastoma
MeSH terms: Case Reports

Background:
Incontinentia pigmenti is a rare X-linked dominant syndrome caused by mutation in the NEMO/IKKgamma gene, and characterized by a spectrum of cutaneous, ocular, neurologic and dental abnormalities. In the eye, findings include retinal vascular non-perfusion, occasionally with traction retinal detachment, retinal fibrosis, and retinal pigment epithelium defects. These findings can resemble retinoblastoma, especially when vitreoretinal fibrosis produces leukocoria.
Case report:
A 2-month-old girl born full-term presented with leukocoria, suspicious for retinoblastoma. She was found to have an ischemic retrolental fibrovascular retinal detachment. In addition, there was linear cutaneous hyperpigmentation, diagnostic of incontinentia pigmenti.
Conclusions:
Retinoblastoma can be a challenge to diagnose. There are numerous simulating lesions that can present with leukocoria and retinal detachment, including incontinentia pigmenti. Recognition of the cutaneous features of incontinentia pigmenti contributes to early detection of related ophthalmologic, neurologic and dental abnormalities.
Do inhabitants profit from integrating a public health focus in urban renewal programmes? A Dutch case study
Authors: Annemarie Ruijsbroek, Albert Wong, Frank den Hertog, Mariël Droomers, Carolien van den Brink, Anton E Kunst, Hans A M van Oers, Karien Stronks
Journal: PLoS One (2022)
MeSH terms: Public Health, Urban Renewal, Research Support, Non-U.S. Gov't, Cross-Sectional Studies, Exercise, Humans, Overweight / psychology

Background:
Urban renewal traditionally involves policy sectors such as housing, transport, and employment, which potentially can enhance the health of residents living in deprived areas. Additional involvement of the public health sector might increase the health impact of these urban renewal activities. This study evaluates the health impact of an additional focus on health, under the heading of Healthy District Experiments (HDE), within districts where an urban renewal programme was carried out.
Methods:
We evaluated changes in health outcomes before the start of the HDE and after implementation, and compared these changes with health changes in control areas, e.g. districts from the urban renewal programme where no additional HDE was implemented. Additionally, we gathered information on the content of the experiments to determine what types of activities have been implemented.
Results:
The additional activities from the HDE were mostly aimed at strengthening the health care in the districts and at promoting physical activity. When we compared the prevalence in general health, mental health, overweight, obesity, smoking, and physical activity during the study period between the HDE districts and control districts, we found no significant differences in the rate of change. The study is limited by a small sample size and the cross-sectional nature of the data. These and other limitations are discussed.
Conclusion:
We found no evidence for a beneficial health impact of the activities that were initiated with a specific focus on health, within a Dutch urban renewal programme. Specific attention for network management and the integration of such activities in the wider programme, as well as an allocated budget might be needed in order to sort a health impact.