OpenMed/multicare-articles huggingface dataset:
Silicone Plate for the Prevention of Postoperative Adhesions in Patients with Asherman Syndrome
Authors: Maho Miyagi, Keiko Mekaru, Sugiko Oishi, Chiaki Urasoe, Kozue Akamine, Yoichi Aoki
Journal: Case Rep Obstet Gynecol (2019)
MeSH terms: Case Reports

Purpose:
Re-adhesion rates following hysteroscopic adhesiolysis have remained high. Accordingly, we present a case involving temporary placement of an intrauterine silicone plate to prevent re-adhesions following hysteroscopic adhesiolysis in a 36-year-old woman with Asherman syndrome.
Methods:
After hysteroscopic adhesiolysis, a silicone plate molded to the uterine cavity's shape was inserted into the uterine cavity and left in place for 1 month.
Results:
The patient had a history of endometrial curettage for endometrial polyps. After the procedure, she developed amenorrhea and experienced infertility for 5 years despite four cycles of in vitro fertilization and embryo transfer. Following admission to our hospital, hysteroscopic examination showed a wide area of intrauterine adhesions for which hysteroscopic adhesiolysis and silicone plate insertion were performed. The silicone plate was removed after 1 month. No intrauterine adhesions were observed during the subsequent hysteroscopic examination. After a thawed embryo transfer, the patient became pregnant and delivered a healthy baby.
Conclusions:
A silicon plate may be considered a useful tool for preventing re-adhesion following hysteroscopic adhesiolysis without serious complications.
Pembrolizumab in FIGO IVB Verrucous Carcinoma of the Vulva: A Case Report
Authors: Yuhan Wang, Rongchun Lin, Bingzhong Zhang, Hui Zhou, Zhongqiu Lin, Tingting Yao
Journal: Front Oncol (2021)
Keywords: chemotherapy, immunotherapy, pembrolizumab, verrucous carcinoma, vulva cancer
MeSH terms: Case Reports

Background:
Vulvar cancer is the fourth most common gynecologic cancer, and prognosis is poor in advanced vulvar cancer patients. Treatment for advanced vulvar cancer has not been satisfactory. In this report, we firstly report a FIGO IVB vulva verrucous carcinoma patient who obtained good prognosis after systemic treatment.
Case presentation:
A patient was admitted to hospital due to her vulvar lesion persistent for past 14 years. The vulvar mass has widely invaded urethra, part of anus, the lower third of the vagina, bilateral superior and inferior branches of pubis, and bilateral internal and external muscles of obturator. Multiple metastatic lymph nodes were also found in the pelvic cavity. The histopathological studies confirmed vulvar verrucous carcinoma with a PD-L1 overexpression. After six courses of neoadjuvant chemotherapy and pembrolizumab, the patient underwent radical vulvectomy and achieved optimal cytoreduction. Postoperative pathology found no residual tumor. The patient then received one course of postoperative chemotherapy and pembrolizumab, underwent radiation therapy, and was disease free after 6 months follow-up.
Conclusion:
Our individualized treatment strategy is successful. Pembrolizumab is safe and effective in the treatment of advanced vulvar verrucous carcinoma with PD-L1 overexpression.
An uncommon cause of ascites: uroperitoneum from iatrogenic bladder fistula detected by CT urography
Authors: Carmelinda Manna, Mario Silva, Silvia Eleonora Gazzani, Rocco Cobelli
Journal: BJR Case Rep (2016)
MeSH terms: Case Reports

We report the case of a female who underwent laparoscopic hysterectomy and was referred to the emergency department with massive ascites 10 days later. Anamnestic background and clinical presentation suggested the occurrence of a urinary lesion, which was investigated by CT urography. CT urography with ultra-late excretory phase showed the leakage of iodinated contrast agent from the bladder dome into the peritoneal cavity, as expected in uroperitoneum from iatrogenic bladder laceration. CT cystography is the reference standard for the assessment of bladder leakage; however, this technique is quite invasive, time consuming and does not provide a panoramic overview of the entire excretory system. Conversely, CT urography provides a complete overview of the entire excretory system by means of an optimized protocol with optional ultra-late acquisition to gain adequate bladder distension and depict minor urinary leakage.
Early Use of Dinutuximab Beta in Patients with High-Risk Neuroblastoma
Authors: Neofit Spasov, Mariya Spasova
Journal: Case Rep Pediatr (2021)
MeSH terms: Case Reports

Neuroblastoma is the most common extracranial solid tumor in children, accounting for 15% of all pediatric cancer deaths. High-risk neuroblastoma (HRNB) is a particularly difficult-to-treat form of the disease that requires aggressive multimodality therapy, including induction chemotherapy, consolidation therapy with high-dose chemotherapy and autologous stem cell transplant, and maintenance therapy with dinutuximab beta. Despite treatment advances, the prognosis of these patients remains poor. As a better response to induction therapy has been associated with prolonged survival in patients with HRNB, we hypothesized that early use of dinutuximab beta-post-induction chemotherapy-may improve patient outcomes. We describe here our experience of administering at least one cycle of dinutuximab beta post-induction and prior to surgery in three children with HRNB who did not demonstrate a complete response to induction chemotherapy. All three patients achieved complete remission. Early use of dinutuximab beta may therefore have the potential to improve outcomes in patients with HRNB.
Rescue of primary incomplete microkeratome flap with secondary femtosecond laser flap in LASIK
Authors: E A Razgulyaeva
Journal: Case Rep Ophthalmol Med (2014)

For laser-assisted in situ keratomileusis (LASIK) retreatments with a previous unsuccessful mechanical microkeratome-assisted surgery, some surgical protocols have been described as feasible, such as relifting of the flap or the creation of a new flap and even the change to a surface ablation procedure (photorefractive keratectomy (PRK)). This case shows the use of femtosecond technology for the creation of a secondary flap to perform LASIK in a cornea with a primary incomplete flap obtained with a mechanical microkeratome. As we were unable to characterize the interface of the first partial lamellar cut, a thick flap was planned and created using a femtosecond laser platform. As the primary cut was very thick in the nasal quadrant, a piece of loose corneal tissue appeared during flap lifting which was fitted in its position and not removed. Despite this condition and considering the regularity of the new femtosecond laser cut, the treatment was uneventful. This case report shows the relevance of a detailed corneal analysis with an advanced imaging technique before performing a secondary flap in a cornea with a primary incomplete flap. The femtosecond laser technology seems to be an excellent tool to manage such cases successfully.
Testosterone Replacement Therapy and the Risk of Hypoglycemia
Authors: Analía Verónica Yamaguchi, Pablo René Costanzo, Verónica Andrea Peuchot, Pablo Knoblovits
Journal: Case Rep Endocrinol (2019)
MeSH terms: Case Reports

We report the case of a 45-year-old man with a history of Klinefelter syndrome undergoing testosterone replacement therapy, and with type 2 diabetes treated with metformin with poor metabolic control. When vildagliptin was added to his treatment, he presented hypoglycemia after the testosterone injection. We highlight this not widely reported drug interaction between hypoglycemic agents and testosterone.
A Japanese neonatal case of glucose-6-phosphate dehydrogenase deficiency presenting as severe jaundice and hemolytic anemia without apparent trigger
Authors: Shinya Tsuzuki, Moe Akahira-Azuma, Masao Kaneshige, Kazuhiro Shoya, Shinichi Hosokawa, Hitoshi Kanno, Takeji Matsushita
Journal: Springerplus (2013)
Keywords: glucose-6-phosphate dehydrogenase deficiency, hemolytic anemia, jaundice, neonate
MeSH terms: Case Reports

Background:
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is rare among Japanese ethnicity although it is known as one of the most common hereditary disorders of erythrocytes, causing intravascular hemolysis. It is well-known that G6PD deficiency may cause hemolysis even in the neonatal period. However, most cases are asymptomatic, and the frequency of severe anemia is low.
Findings:
We describe a Japanese male neonatal case of G6PD deficiency presenting as severe, persistent indirect hyperbilirubinemia on day 2 and hemolytic anemia. He was born to non-consanguineous Japanese parents without any family history. We could not find any triggers that could have induced hemolysis during pregnancy.
Conclusions:
This case encouraged us to investigate G6PD deficiency as a differential diagnosis of severe neonatal jaundice and hemolytic anemia despite the low prevalence in Japan.
Phlegmonous Gastritis in a Patient With Nonalcoholic Steatohepatitis-Related Cirrhosis: A Case Report and Review of Literature
Authors: Norikazu Iwata, Yasushi Adachi, Yukinari Yoshida, Yoshifumi Ishii, Takao Endo
Journal: Cureus (2023)
Keywords: autopsy, moraxella (branhamella) catarrhalis, nonalcoholic steatohepatitis-related cirrhosis, phlegmonous gastritis, sepsis-induced liver dysfunction
MeSH terms: Case Reports

It is sometimes difficult to diagnose phlegmonous gastritis clinically. We herein present a rare autopsy report of a patient with phlegmonous gastritis associated with nonalcoholic steatohepatitis-related cirrhosis. The patient died of hepatic failure two weeks after exacerbation of anorexia and rapid progression of liver dysfunction. Autopsy revealed cholangitis lenta and sepsis-induced liver dysfunction, which was attributed to phlegmonous gastritis due to Moraxella (Branhamella) catarrhalis. Phlegmonous gastritis has seldom been reported in patients with liver cirrhosis. We believe the importance of keeping in mind that phlegmonous gastritis could be one of the complications of advanced liver cirrhosis.
Laparoendoscopic Single-Site Surgery (LESS) for a Large Ovarian Tumour: First Clinical Case Report
Authors: Yao Dong Chua, Ying Woo Ng, Yoke Fai Fong
Journal: Minim Invasive Surg (2011)
MeSH terms: Case Reports

Objective. To report the feasibility of removing a 10 cm ovarian fibroma via a laparoendoscopic single-site trocar through trans-umbilical access. Design. Case report. Setting. Teaching and research hospital. Patient. A 64-year-old patient affected by a large 10 cm ovarian tumour. Intervention(s). Bilateral salpingo-oophorectomy a large 10 cm ovarian tumour, using a laparoendoscopic single-site approach with a Covidien SILS multitrocar access device and standard laparoscopic instruments. Main Outcome Measure(s). Conversion to standard laparoscopic technique or laparotomy, estimated blood loss, operative time , extent of scarring, occurrence of intra- and perioperative surgical complications, technical adequacy, and clinical outcome. Result(s). No conversion to standard laparoscopic technique or laparotomy, and no intraoperative or postoperative complications were observed. Total operative time was 99 minutes. The patient was discharged home on postoperative day one. Conclusion(s). Laparoendoscopic single-site bilateral salpingo-oophorectomy of a large ovarian tumour is feasible with standard laparoscopic instruments. It is safe and effective, with good results in terms of excellent cosmesis and minimal postoperative pain.
Lichen myxedematosus associated with monoclonal gammopathy of undetermined significance: A case report and literature review
Authors: Hua Huang, Shen-Xian Qian
Journal: Front Med (Lausanne) (2023)
Keywords: glucocorticoids, lichen myxedematosus, monoclonal gammopathy, monoclonal gammopathy and skin changes syndrome, monoclonal gammopathy of clinical significance, thalidomide
MeSH terms: Case Reports

Lichen myxedematosus (LM) is an idiopathic cutaneous mucinosis disorder, and monoclonal gammopathy of undetermined significance (MGUS) is a preneoplastic plasma cell disease with a monoclonal increase in globulin. Patients with LM combined with monoclonal gammopathy are normally diagnosed with scleromyxedema. However, we report a case of generalized papules combined with MGUS in a 78-year-old man who was eventually diagnosed with atypical or intermediate forms of LM because it only involved the skin, and the pathological type was not consistent with scleromyxedema. Few cases of atypical or intermediate forms of LM have been reported, so the course of atypical or intermediate forms of LM is unpredictable. We report the diagnosis and treatment of a case of atypical forms of LM to discuss the current understanding of the disease, hoping to provide a reference for clinical research on this disease.
Large spontaneous subcapsular hematoma of the liver: a rare case report
Authors: Abdulrahman Al Tamimi, Awad Ali Alawad
Journal: Pan Afr Med J (2019)
Keywords: spontaneous, liver, subcapsular hematoma
MeSH terms: Hematoma / diagnostic imaging, Liver Diseases / diagnostic imaging, Tomography, X-Ray Computed / methods, Case Reports, Adult, Conservative Treatment / methods, Hematoma / pathology, Hematoma / therapy, Humans, Liver Diseases / pathology, Liver Diseases / therapy, Male

Spontaneous subcapsular hematoma of the liver is an extremely rare but potentially life-threatening condition. We report a case of subcapsular hematoma of the liver without any apparent lesion and in the absence of coagulopathy or trauma. A CT scan of the abdomen demonstrated a huge subcapsular hematoma around the liver. The patient was treated conservatively and was discharged home after one week. Up to our knowledge, this is one of the very few reported cases of a spontaneous subcapsular hepatic hematoma.
Post-operative emergence of acute brachial neuritis following posterior cervical laminectomy with fusion: A case report and review of the literature
Authors: Raj H Patel, Rishi N Sheth
Journal: Int J Surg Case Rep (2019)
Keywords: brachial neuritis, cervical laminectomy, neuralgic amyotrophy, neuropathy, post-surgical, shoulder pain

Introduction:
Idiopathic brachial plexus neuritis or neuralgic amyotrophy is a rare neurological condition whose true etiology currently remains unknown. Epidemiologically, the incidence of this condition is exceptionally rare with only 1.6 cases for every 100,000 people (Turner and Parsonage, 1987). Symptoms present an initial acute and sudden pain to the shoulder girdle and upper arm which is followed by a sense of profound weakness and numbness to the upper arm (Parsonage and Turner, 1948). Localized neuropathy within the arm-pit region may also be presented. The pain often exacerbates upon movement of the shoulder. Due to the anatomic location affected and the nature of the clinical symptoms presented, accurate diagnosis of brachial plexus neuritis poses a challenging diagnostic task for physicians due to remarkably similar symptoms expressed by differential diagnoses.
Presentation of case:
Here, we report the case of a 55-year-old woman who underwent surgery entailing cervical laminectomy with instrumented fusion. She presented with postoperative symptoms of severe pain in the left arm with significant weakness within 24 h after surgery. A diagnosis of brachial plexus neuritis was made based on the symptoms presented and upon review of imaging scans.
Discussion:
After a six-month follow-up visit, the patient recovered from the brachial neuritis but has residual numbness in the hand. The presentation of this case serves to transmit three fundamental purposes. First, this case serves to establish an intriguing possible association of the post-surgical period of cervical laminectomy with acute brachial neuritis and signifies the importance post-operative linkage with brachial neuritis in general. Second, this case also highlights the importance of close clinical monitoring of patients with unique symptoms within the postoperative follow-up period to ensure successful improvement and accurate diagnosis.
Conclusion:
As an underdiagnosed and relatively obscure condition, this case serves as an imperative reference for physicians to illuminate differential diagnosis of similar symptomatic conditions and also to promote knowledge of brachial plexus neuritis which can lead to an early and precise diagnosis.
Intramedullary Nail Fixation with Autologous Bone Marrow Transplantation in an Incomplete Atypical Femoral Fracture Patient: Use of Bone Marrow Extracted from the Hollow Reamer
Authors: Ryutaro Iwasaki, Masaaki Sakamoto, Tomoyuki Rokkaku, Hitoshi Watanabe, Toshiyuki Yamada, Takeshi Yamaguchi, Yasushi Wako, Hitoshi Kubosawa, Seiji Ohtori
Journal: Case Rep Orthop (2020)
MeSH terms: Case Reports

The present report describes an incomplete atypical femoral fracture (AFF) patient who underwent simultaneous autogenous bone transplantation to the resected fracture region during intramedullary nail fixation. A 73-year-old female with a history of multiple myeloma had been undergoing treatment with intravenous drip injections of Zoledronic Acid. She was introduced to our department due to the left lateral thigh pain, with no trauma incidence. An anteroposterior radiograph showed a transverse thin fracture line with localized periosteal and endosteal thickening, which is compatible with subtrochanteric incomplete AFF. A biochemical investigation revealed the existence of severely suppressed bone turnover. She underwent intramedullary nail fixation for fear of a complete fracture. After the fixation, the cortical bone at the fracture region was excised as a wedge-shaped block, and bone marrow extracted from the hollow reamer was simultaneously transplanted to the resected fracture region. Histological examination showed few bone formation features at the fracture line in the excised lateral cortical bone. At 7 months after surgery, radiographs demonstrated complete bone repair, and no clinical problems were observed two years postoperatively. To the best of our knowledge, this is the first report in which autogenous bone marrow transplantation, noninvasive to the iliac crest, was performed in an incomplete AFF patient. We believe that this low invasive procedure can be a useful technique for AFF treatment.
Primary malignant melanoma of prostate: a case report
Authors: Pirzada Faisal Masood, Umesh Sharma, Rajeev Sood, Arvind Ahuja
Journal: Pan Afr Med J (2023)
Keywords: melanoma, case report, metastasis, prostate
MeSH terms: Melanoma / pathology, Prostatic Neoplasms / pathology, Skin Neoplasms / pathology, Case Reports, Humans, Male, Middle Aged, Prognosis, Prostate / pathology, Melanoma, Cutaneous Malignant

While primary genitourinary melanomas account for less than 1% of all melanoma cases, prostatic melanoma is extremely uncommon. These patients are challenging to identify, with a dismal prognosis. We reported a 52-year-old male patient who presented with lower urinary tract symptoms in the last one and a half months. The patient underwent Holmium laser enucleation of the prostate, and the histopathology result of the resected specimen showed prostatic melanoma. Investigations for systemic melanoma evaluation were negative, and the patient underwent radical cystoprostatectomy, urethrectomy, and bilateral lymph node dissection. The patient refused chemotherapy, developed lung metastasis shortly after surgery at three months, and succumbed to the metastatic disease with overall survival of 6 months. In conclusion, primary malignant melanoma of the prostate is a very rare disease. The most logical therapeutic strategy is aggressive surgical resection, followed immediately by adjuvant therapy.
Hydropneumothorax Revealing a Pneumoblastoma in Children
Authors: Karima El Fakiri, Ghizlane Draiss, Noureddine Rada, Mohammed Bouskraoui, Abderrachid Hamdaoui, Mohamed Oulad Saiad
Journal: Case Rep Pediatr (2020)
MeSH terms: Case Reports

Pneumoblastoma is a rare primary childhood tumor. We report the observation of an infant aged 2 years and 8 months who presented with dry cough and dyspnea. The physical examination found mixed pleural effusion syndrome on the right. The chest X-ray revealed a right pneumothorax. Biology has shown leukocytosis at 16,000/mm3. The CT scan revealed parenchymal air cystic lesions affecting the outer segment of the middle lobe mimicking a pulmonary malformation. Thoracic drainage brought back 100 ml of the fluid. Two months later, when a pyopneumothorax appeared, a medium lobectomy was performed. Pathological study specimen showed a high-grade type II pneumoblastoma The extension assessment identified a secondary hepatic location. Chemotherapy has been indicated. This observation illustrates the diagnosis challenge of pneumoblastoma in children.
Pancreaticoduodenectomy for locally advanced colon cancer in hereditary nonpolyposis colorectal cancer
Authors: Rebecca Zhu, Gabriella Grisotti, Ronald R Salem, Sajid A Khan
Journal: World J Surg Oncol (2016)
MeSH terms: Adenocarcinoma / surgery, Colectomy, Colorectal Neoplasms, Hereditary Nonpolyposis / surgery, Pancreaticoduodenectomy, Case Reports, Review, Adenocarcinoma / pathology, Adult, Colorectal Neoplasms, Hereditary Nonpolyposis / pathology, Humans, Male, Middle Aged, Neoplasm Staging

Background:
Hereditary nonpolyposis colorectal cancer (HNPCC), or Lynch syndrome, accounts for 3% of newly diagnosed cases of colorectal cancer. While a partial or subtotal colectomy is indicated for early stage disease, there is a paucity of data addressing locally advanced disease involving the foregut.
Case presentation:
We report two patients with hereditary nonpolyposis colorectal cancer presenting with locally advanced colon cancer surgically managed by pancreaticoduodenectomy with en bloc partial colectomy and a review of the literature.
Conclusions:
Locally advanced colorectal cancer in HNPCC is a rare clinical entity that requires special surgical consideration. Multidisciplinary treatment, including multi-visceral resection, offers the best long-term outcome.
Case Report: Left atrial myxoma with confirmed Delta variant COVID-19 infection, "to treat or withhold"
Authors: Sally Aman Nasution, Eric Daniel Tenda, Eka Ginanjar, Nuri Dyah Indrasari, Ariel Pradipta, Mira Yulianti, Muhadi Muhadi, Anindya Pradipta Susanto, Muhammad Arza Putra, Moses Mazmur Asaf, Ceva Wicaksono Pitoyo, Imam Subekti, Ari Fahrial Syam, Lies Dina Liastuti
Journal: F1000Res (2022)
Keywords: covid-19, delta variant, myxoma, primary cardiac tumors
MeSH terms: COVID-19 / complications, Heart Neoplasms / complications, Heart Neoplasms / pathology, Heart Neoplasms / surgery, Myxoma / complications, Myxoma / pathology, Myxoma / surgery, Case Reports, Heart Atria / pathology, Heart Atria / surgery, Humans, Pandemics, SARS-CoV-2, SARS-CoV-2 variants

Primary cardiac tumors (PCTs) are extremely rare entities. More than half of PCTs are benign, with myxoma being the most common tumor. Generally, simple tumor resection is the treatment of choice for benign PCTs since it has promising results that yield low complication and recurrence rates. However, in the COVID-19 pandemic era, the mitigation protocols and/or concurrent COVID-19 infection should be taken into account in patient management for the best overall outcome. To our knowledge, this is the first case report of a patient with a left atrial myxoma and systemic embolism complication in the form of an ischemic stroke, with a concurrent confirmed COVID-19 delta variant infection.