OpenMed/multicare-articles huggingface dataset:
A Rare Case of Sudden Death in a Patient with Takotsubo Cardiomyopathy Secondary to Cardiac Rupture
Authors: Tarun Dalia, Bashar S Amr, Ankit Agrawal, Archana Gautam, Venkata Rakesh Sethapati, Jared Kvapil
Journal: Case Rep Cardiol (2019)
MeSH terms: Case Reports

Takotsubo cardiomyopathy (TCM), also known as broken heart syndrome or stress-induced cardiomyopathy, is a rare condition with an estimated incidence of 0.02% of all hospitalizations in United States and 2% of all acute coronary syndrome presentations. TCM predominately presents as a transient wall motion abnormality of the left ventricular apex due to emotional or physical stress. Cardiac rupture in the setting of TCM is an extremely rare phenomenon with limited published case reports. We present a case of a 75-year-old female who had cardiac rupture secondary to TCM and performed a literature review using Ovid MEDLINE for published cases showing this association. After the literature review, we found 20 cases showing this association, which are listed in a tabular fashion.
Effects of Oral Ginger Supplementation on the INR
Authors: Daniel Rubin, Vishal Patel, Eric Dietrich
Journal: Case Rep Med (2019)
MeSH terms: Case Reports

Although there are competing options for anticoagulation, many Americans remain on warfarin. Concurrently, the use of alternative medicines is on the rise. With that, the potential for interactions between them is increasing. Ginger has gained popularity in its use. The literature has sparse recent information about the potential conflict between warfarin and ginger. This brief case report discusses the potential scope of the problem as well as the proposed pharmacokinetic and pharmacodynamic interactions between these two commonly used agents.
Virtual Surgical Planning and Piezoelectric Surgery in Tumor Extirpative Surgery Aimed at Inferior Alveolar Nerve Preservation
Authors: Eric L Chung, Faizan Alawi, Anh D Le, Rabie M Shanti
Journal: Case Rep Surg (2017)
MeSH terms: Case Reports

A myriad of extirpative surgical protocols for the management of benign tumors of the jaws have been presented in the literature. Through significant advancements in computer-aided design and computer-aided manufacturing (CAD/CAM) technology and surgical instrumentation, today surgeons have at their disposal robust technology-driven techniques that are aimed at improving surgical outcomes. Our goal is to investigate the benefits of implementing virtual surgical planning (VSP) in conjunction with piezoelectric surgery (PES) to ensure success while minimizing the risk of complications during extirpation of tumors of the mandible. This case report describes the successful extirpation of an ossifying fibroma of the mandible in an adult patient using both VSP and PES.
Clinical Report of Probable Catastrophic Antiphospholipid Syndrome in Pregnancy
Authors: Eryk Hakman, Sasha Mikhael
Journal: Case Rep Obstet Gynecol (2018)
MeSH terms: Case Reports

Background:
Catastrophic APS (CAPS) is a rare but life-threatening form of APS defined as multiorgan thrombosis affecting a minimum of three organs with confirmation by histopathology of small vessel occlusions in at least one organ or tissue. The development of CAPS in pregnancy poses many diagnostic challenges as a result of its broad range of clinical presentations and its overlap with other obstetric complications and microangiopathic diseases. Because of the high associated mortality rate, prompt recognition and treatment are paramount.
Case:
A twenty-five-year-old G3P0111 with a history of multiple thromboembolisms presented at 21 weeks and 3 days of gestation with complaints of right upper quadrant pain, visual disturbances, headache, and syncopal episodes. Laboratory evaluation demonstrated microangiopathic disease with hemolysis (confirmed on peripheral smear), elevated liver enzymes, and abnormal 24-hour urine protein with vital signs within the normal range. Presence of significantly elevated antiphospholipid antibodies was noted, facilitating the diagnosis of probable CAPS. Proper workup was achieved based on clinical suspicion, allowing immediate and appropriate management.
Conclusion:
CAPS is a life-threatening condition rarely seen in pregnancy making early recognition difficult. A low threshold to initiate urgent and aggressive treatment should be maintained to minimize the risk of adverse outcomes.
Rapid recovery of visual acuity after lumboperitoneal shunt operation in malignant idiopathic intracranial hypertension
Authors: Levent Sinan Bir, Eylem Degirmenci, Cagdas Erdogan, Selma Bilgin, Erdal Coşkun
Journal: Case Rep Ophthalmol Med (2011)
MeSH terms: Case Reports

Background. Idiopathic intracranial hypertension can cause rapid deterioration of visual acuity in some severe cases, and these cases are usually thought to have "malignant" form of this disease. Case. In this paper, we report on a 16-year-old girl who is a typical example for malignant idiopathic intracranial hypertension with a rapid recovery of visual acuity after lumboperitoneal shunt operation. Observations and Conclusions. Malignant form of idiopathic intracranial hypertension must be kept in mind in selected patients to avoid irreversible visual loss.
BRAF Inhibitors for BRAF V600E Mutant Colorectal Cancers: Literature Survey and Case Report
Authors: Yasar Subutay Peker, Mehmet Fatih Can, Ismail Hakki Ozerhan, Gokhan Yagci, Nazif Zeybek, Kutan Kavakli, Sedat Gurkok, Alper Gozubuyuk, Onur Genc, Gokhan Erdem, Ahmet Ozet, Mustafa Gerek, Yusuf Peker
Journal: Case Rep Surg (2018)
MeSH terms: Case Reports

The main method of fighting against colon cancer is targeted treatment. BRAF inhibitors, which are accepted as standard treatment for V600E mutant malign melanomas, are the newest approach for targeted treatment of V600E mutant colorectal cancers. In this case report, we share our experience about the use of BRAF inhibitor vemurafenib on a V600E mutant metastatic right colon adenocarcinoma patient. A 59-year-old male with only lung multiple metastatic V600E mutant right colon cancer presented to our clinic. The patient was evaluated and FOLFOX + bevacizumab treatment was initiated, which was then continued with vemurafenib. A remarkable response was achieved with vemurafenib treatment in which the drug resistance occurred approximately in the sixth month. Even though the patient benefited majorly from vemurafenib, he died on the 20th month of the diagnosis. The expected overall survival for metastatic V600E mutant colon adenocarcinoma patients is 4.7 months. BRAF inhibitors provide new treatment alternatives for V600E mutant colorectal cancers, with prolonged overall survival. BRAF inhibitors in combination with MEK inhibitors are reported as feasible treatment to overcome BRAF inhibitor drug resistance on which phase studies are still in progress. To conclude, BRAF inhibitors alone or in combination with other drugs provide a chance for curing BRAF V600E mutant colorectal cancer patients.
Florid Proliferation of Hyalinized Vessels in a Spermatic Cord STAT6 Positive Solitary Fibrous Tumor and Its Potential Clinical Implications
Authors: Christopher P Marquez, Haiyan Zhang, Jason Goodrum, J Nicholas Sreshta, Marjan Afrouzian
Journal: Case Rep Pathol (2018)
MeSH terms: Case Reports

A solitary fibrous tumor (SFT) arising in the paratesticular region is a rare event. Typically most SFTs present as a lung mass and have a characteristic microscopic appearance. Although uncommon, SFTs may present at just about any anatomical site. Here we present a case of a SFT arising along the right spermatic cord, with histologic features mimicking a cellular angiofibroma. We describe the diagnostic immunohistochemical markers useful for arriving at its diagnosis. We also summarize our current understanding of the structural and molecular features that make up SFTs and discuss how these features may help us better understand the pathophysiology of pluripotent mesenchymal stem cell differentiation.
Cecal duplication cyst presenting with acute abdomen: a case report
Authors: Menawar Dajenah, Faisal Ahmed, Abdullatif Almohtadi, Anessa Thabet, Khaled Ghaleb, Fayed Al-Yousofy, Fawaz Mohammed
Journal: Pan Afr Med J (2022)
Keywords: cecal duplication cyst, adults, case report, intestinal obstruction
MeSH terms: Abdomen, Acute / diagnosis, Abdomen, Acute / etiology, Abdomen, Acute / surgery, Cysts / diagnosis, Cysts / surgery, Case Reports, Abdominal Pain / surgery, Adult, Cecum / surgery, Colectomy, Humans, Male, Young Adult

Cecal duplication cyst is a rare congenital malformation with a few reported adult cases. We present a 23-year-old man who presented with low-grade fever, constipation, and right lower quadrant pain for three days. An abdominal computed tomography scan showed a cystic mass of 8.8x7.5x6 cm adjoining to the posterior wall of the cecum. The patient underwent abdominal laparotomy, and a right hemicolectomy was performed with resection of the duplication cyst. The histopathological study confirmed the diagnosis of a non-communicating cecal duplication cyst. In conclusion, it is essential to include cecal duplication cyst in the differential diagnosis of the acute abdomen to guarantee the best treatment strategy.
Case Report: Venous pulsatile tinnitus induced by enlarged oblique occipital sinus and resultant diverticulum/dehiscence of the sigmoid-jugular wall
Authors: Yue-Lin Hsieh, Shenjiang Wang, Wuqing Wang
Journal: Front Surg (2023)
Keywords: dehiscence, diverticulum, oblique occipital sinus, occipital sinus, pulsatile tinnitus
MeSH terms: Case Reports

Pulsatile tinnitus (PT) caused by enlarged oblique occipital sinus (OOS) and resultant diverticulum/dehiscence of the sigmoid-jugular wall has not been described in previous literature. This study recruits one case of PT induced by ipsilateral enlarged OOS and sigmoid-jugular wall diverticulum (case 1) alongside one case of PT induced by ipsilateral enlarged OOS and sigmoid-jugular wall dehiscence (case 2). Various radiologic and computational techniques including computed tomography (CT), magnetic resonance (MR) imaging, Doppler ultrasound, and computational fluid dynamics (CFD) simulation were implemented. Transmastoid sinus wall reconstruction was performed on case 1 with a large sigmoid-jugular diverticulum potentially traumatizing the facial nerve canal. Contrast-enhanced CT or MR venogram images coupling with three-dimensional reconstructed are advantageous in revealing the covert route of OOS that runs under the cerebellum and drains directly into jugular bulb (JB) region. PT in case 1 was successfully eliminated after transmastoid sinus wall reconstruction surgery. Tinnitus handicap inventory score in case 1 reduced from 70 to 0. The ipsilateral jugular outflow mean velocity (Vmn) and flow volume (FVOL) were 42.5 cm/s and 25.9 g/s (case 1 prior to surgery) and 56.6 cm/s and 41.2 g/s (case 2), respectively. Based on CFD simulation, the peak flow velocity in OOS was 1.85 m/s and 2.1 m/s, the wall pressure of the diverticular dome and dehiscence area of the SS-JB wall was 1724.7 Pa and 369.8 Pa in case 1 and 2, respectively. Enlarged OOS caries greater flow kinetic energy that possibly induces sigmoid-jugular wall diverticulum/dehiscence; transmastoid surgical method is safe and therapeutically effective against PT induced by enlarged OOS.
Conservative management of placenta accreta in a multiparous woman
Authors: Jennifer C Hunt
Journal: J Pregnancy (2010)
MeSH terms: Endometritis / etiology, Ileus / etiology, Peritonitis / etiology, Placenta Accreta / therapy, Placenta, Retained / etiology, Case Reports, Abortifacient Agents, Nonsteroidal / therapeutic use, Adult, Anti-Bacterial Agents / therapeutic use, Bacteremia / microbiology, Bacteroidaceae Infections / diagnosis, Chorionic Gonadotropin, beta Subunit, Human / blood, Delivery, Obstetric, Endometritis / therapy, Female, Hemoperitoneum / etiology, Hemoperitoneum / therapy, Humans, Hysterectomy, Ileus / therapy, Intestinal Obstruction, Methotrexate / therapeutic use, Obstetric Labor, Premature, Parity, Peritonitis / therapy, Placenta, Retained / surgery, Postoperative Complications, Postpartum Hemorrhage / etiology, Postpartum Hemorrhage / therapy, Pregnancy, Prevotella / isolation & purification, Uterus / microbiology, Abortifacient Agents, Nonsteroidal, Anti-Bacterial Agents, Chorionic Gonadotropin, beta Subunit, Human, Methotrexate

Placenta accreta refers to any abnormally invasive placental implantation. Diagnosis is suspected postpartum with failed delivery of a retained placenta. Massive obstetrical hemorrhage is a known complication, often requiring peripartum hysterectomy. We report a case of presumed placenta accreta in a patient following failed manual removal of a retained placenta. We describe an attempt at conservative management with methotrexate in a stable patient desiring future fertility. Treatment was unsuccessful and led to the development of a disseminated intrauterine infection complicated by a bowel obstruction, requiring both a hysterectomy and small bowel resection. In hemodynamically stable patients, conservative management of placenta accreta may involve leaving placental tissue in situ with subsequent administration of methotrexate. However, ongoing close observation is required to identify complications.
Oral and dental findings of dyskeratosis congenita
Authors: Mine Koruyucu, Pelin Barlak, Figen Seymen
Journal: Case Rep Dent (2014)

Dyskeratosis congenital (DC) is a rare condition characterized by reticulate skin hyperpigmentation, mucosal leukoplakia, and nail dystrophy. More serious features are bone marrow involvement with pancytopenia and a predisposition to malignancy. The purpose of this case report is to describe the oral and dental findings in children with DC syndrome. A 10-year-old male diagnosed with DC was admitted because of extensive caries and toothache. Inadequate oral hygiene and extensive caries were observed in oral examination of the patient. Plaque accumulation was seen in gingival border of maxillary teeth. Papillary atrophy on the tongue was observed. Short and blunted roots of mandible incisors and upper and lower molars were determined on the radiographic examination. Dryness on the lips and commisuras, ectropion on his eyes, and epiphora were observed. Hematologic tests were performed and showed aplastic anemia at the age of 2. At the age of 4, the bone marrow transplantation was performed. Dermatological findings occurred after the bone marrow transplantation. The skin of the patient was thin, dry, and wrinkled in some areas. He had palmoplantar hyperkeratosis and syndactylia on his fingers. Endodontic treatment procedures were applied and other extensive caries are still being restored. The patient will be given full preventive care during regular follow-up. Oral hygiene was improved to the optimum level.
Sequelae of Acute Respiratory Distress Syndrome: Interest of Rehabilitation
Authors: Elise Godeau, David Debeaumont, Elise Artaud-Macari, Laurie Lagache, Gurvan Le Bouar, Jérémy Coquart
Journal: Case Rep Crit Care (2019)
MeSH terms: Case Reports

Case presentation:
This clinical case presents the history of a woman hospitalized for acute respiratory distress syndrome (ARDS). A 62-year-old woman, with regular physical activity and no history of respiratory disease or smoking, was hospitalized for moderate ARDS with bilateral pneumonitis. Fourteen days later, she was discharged from the intensive care unit and received respiratory physical therapy. One month later, she experienced exertional dyspnea. A regression of alveolar condensation with persistent sequelae at the pulmonary bases was noted. Three months later, the patient continued daily physical activity with satisfactory tolerance. A reduction in alveolar-capillary transfer, inappropriate hyperventilation upon exercise, and impairment of gas exchanges at maximal effort, suggestive of pulmonary shunt, were demonstrated. At the 6-month evaluation, the patient displayed exertional dyspnea with residual bilateral basal consolidations. Six months later, the dyspnea had ceased. The persistence of bilateral basal interstitial syndrome associated with bronchial dilatation and pleural-based consolidations was noted, as well as a stable impaired alveolar-capillary diffusing capacity.
Discussion:
Upon discharge from intensive care, pulmonary follow-up should be proposed to ARDS survivors. Moreover, pulmonary function testing at rest and exercise is advised as soon as possible to evaluate the respiratory sequelae. This will help to limit the severity of complications through adapted exercise rehabilitation and then regular physical activity.
Gonococcal polyarthritis with sternoclavicular joint involvement in pregnant woman: a case report
Authors: Imane El Mezouar, Latifa Tahiri, Faiza Lazrak, Khadija Berrada, Taoufik Harzy
Journal: Pan Afr Med J (2014)
Keywords: gonococcal polyarthritis, pregnancy, sternoclavicular joint
MeSH terms: Arthritis, Infectious / complications, Gonorrhea / complications, Pregnancy Complications, Infectious / physiopathology, Case Reports, Arthritis, Infectious / microbiology, Arthritis, Infectious / physiopathology, C-Reactive Protein / metabolism, Female, Gonorrhea / diagnosis, Gonorrhea / physiopathology, Humans, Neisseria gonorrhoeae / isolation & purification, Pregnancy, Pregnancy Complications, Infectious / diagnosis, Pregnancy Complications, Infectious / microbiology, Pregnancy Outcome, Pregnancy Trimester, Second, Trichomonas Vaginitis / complications, Trichomonas Vaginitis / diagnosis, Trichomonas vaginalis / isolation & purification, Young Adult, C-Reactive Protein

Pregnancy is one of conditions that increase the risk of gonococcal arthritis which result from blood dissemination of neisseria gonorrhoeae. A 20-year-old africain female patient (in the second trimester of pregnancy), was admitted to hospital because of fever, asymmetric joint swollen affecting the hands, wrists, left ankle, and right sternoclavicular joint. Laboratory findings (erythrocyte sedimentation rate was 117 mm in first hour, The serum C-reactive protein level was 152 mg/L) the gram stain of genital sample was positif of neisseria gonorrhoeae and trichomonas vaginalis. With antibiotics, outcome of pregnancy was timely and uneventful. Patients should be educated about the mode of transmission of gonorrhea. Sexual partners should also be treated to prevent dissemination and gonococcal re-infection.
Case study: Targeted RNA-sequencing of aged formalin-fixed paraffin-embedded samples for understanding chemical mode of action
Authors: Michael D Cannizzo, Charles E Wood, Susan D Hester, Leah C Wehmas
Journal: Toxicol Rep (2022)
Keywords: aic, akaike information criterion, bmd, benchmark dose, bmda, traditional benchmark dose based on apical endpoint, bmdl, lower 95% confidence limit of benchmark dose, bmdt, transcriptomic benchmark dose, bmdu, upper 95% confidence limit of benchmark dose, benchmark dose (bmd) analysis, cpm, counts per million, dca, dca, dichloroacetic acid, deg, differentially expressed gene, dos, detector oligos, dichloroacetic acid, fdr, false discovery rate, ffpe, formalin-fixed paraffin-embedded, froz, frozen, formalin-fixed paraffin-embedded (ffpe), go, gene ontology, iris, integrated risk information system, nam, new approach method, phred score, negative log10 of the base-calling error probability, rin, rna integrity number, rna-seq, rna-seq, rna-sequencing, tempo-seq, tempo-seq, templated oligo sequencing

Formalin-fixed paraffin-embedded (FFPE) samples are the only remaining biological archive for many toxicological and clinical studies, yet their use in genomics has been limited due to nucleic acid damage from formalin fixation. Older FFPE samples with highly degraded RNA pose a particularly difficult technical challenge. Probe-based targeted sequencing technologies show promise in addressing this issue but have not been directly compared to standard whole-genome RNA-Sequencing (RNA-Seq) methods. In this study, we evaluated dose-dependent transcriptional changes from paired frozen (FROZ) and FFPE liver samples stored for over 20 years using targeted resequencing (TempO-Seq) and whole-genome RNA-Seq methods. Samples were originally collected from male mice exposed to a reference chemical (dichloroacetic acid, DCA) at 0, 198, 313, and 427 mg/kg-day (n = 6/dose) by drinking water for 6 days. TempO-Seq showed high overlap in differentially expressed genes (DEGs) between matched FFPE and FROZ samples and high concordance in fold-change values across the two highest dose levels of DCA vs. control (R2 ≥ 0.94). Similarly, high concordance in fold-change values was observed between TempO-Seq FFPE and RNA-Seq FROZ results (R2 ≥ 0.92). In contrast, RNA-Seq FFPE samples showed few overlapping DEGs compared to FROZ RNA-Seq (≤5 for all dose groups). Modeling of DCA-dependent changes in gene sets identified benchmark doses from TempO-Seq FROZ and FFPE samples within 1.4-fold of RNA-Seq FROZ samples (93.9 mg/kg-d), whereas RNA-Seq FFPE samples were 3.3-fold higher (310.3 mg/kg-d). This work demonstrates that targeted sequencing may provide a more robust method for quantifying gene expression profiles from aged archival FFPE samples.
Cerebral venous sinus thrombosis after COVID-19 vaccination: a case report and literature review
Authors: Mohamed Elfil, Mohammad Aladawi, Dmitry Balian, Ismail Fahad, Daniel J Zhou, Brian Villafuerte-Trisolini, Thomas Scott Diesing
Journal: Oxf Med Case Reports (2023)
MeSH terms: Case Reports

As COVID-19 vaccines became widely available, there have been reports of neurovascular complications. In this article, we aim to report a case of cerebral venous sinus thrombosis (CVST) induced by COVID-19 vaccination, with a literature review on similar cases as well as the potential pathophysiological mechanisms. Our case is a healthy male who developed headache, vomiting, photophobia and diplopia after receiving the Ad26.COV2.S vaccine. Fundus examination showed papilledema, and magnetic resonance imaging of the brain and cerebral veins showed CVST involving the superior sagittal sinus and right transverse sinus extending into the right jugular vein. Hypercoagulability workup was unremarkable, and the patient received immunotherapy and anticoagulation. Following this treatment, symptoms resolved, and he had no residual neurologic deficits. Developing neurologic manifestations, especially severe headaches with papilledema, after COVID-19 vaccination should warrant neuroimaging. Early recognition and management of CVST are essential for good clinical outcomes.