OpenMed/multicare-articles huggingface dataset:
Case Report: A rare case of familial lung cancer requiring pneumonectomy in three male siblings
Authors: Andrey Kaprin, Oleg Pikin, Andrey Ryabov, Oleg Aleksandrov, Evgeniy Toneev, Ludmila Lubchenko, Ekaterina Zelenova
Journal: Front Oncol (2022)
Keywords: familial cancer, genome sequencing, immunotherapy, lung cancer, pneumonectomy
MeSH terms: Case Reports

Lung cancer is a disease with a unique genetic pattern and is occasionally related to hereditary syndromes such as Lynch, Louis-Bar, and Li-Fraumeni. In some patients, germinal mutations may be discovered in combination with somatic alterations. For instance, Li-Fraumeni syndrome often reveals a mixture of TP53 and EGFR mutations. The development of new target therapies necessitates an extensive search for new pathogenic mutations. In this article, we present a rare case report of lung cancer, requiring a pneumonectomy, in three sibling brothers.
Good Rehabilitation Outcomes and Improved Nutritional Status After Treatment With the Japanese Herbal Medicine Ninjin'yoeito in an Elderly Patient With Hip Fracture and Sarcopenia: A Case Report
Authors: Akinori Morinaga, Hiroki Nakamura, Kenji Hattanmaru, Natasya Trivena Rokot, Yoko Kimura, Takashi Ito
Journal: Front Nutr (2020)
Keywords: body composition, frailty, hip fracture, malnutrition, ninjin'yoeito, rehabilitation, sarcopenia
MeSH terms: Case Reports

We report a case involving a 92-year-old man who successfully received treatment with ninjin'yoeito, a Japanese herbal medicine, during the rehabilitation phase after hip fracture surgery. The patient was diagnosed with a left femoral neck fracture and underwent surgery. Two weeks after surgery, he was admitted to a rehabilitation hospital. At that time, his height, weight, body fat percentage, muscle mass, and Functional Independence Measure (FIM) score were 167 cm, 61 kg, 34.1%, 38.2 kg, and 49, respectively. For 1 month after surgery (i.e., 2 weeks after admission to the rehabilitation facility), he received rikkunshito, a traditional Japanese herbal medicine also known as Kampo medicine, for appetite loss and underwent rehabilitation. However, his appetite loss showed no improvement, and rikkunshito (7.5 g/d) was replaced with ninjin'yoeito (7.5 g/d). Two months later, although the patient's body weight and body fat percentage decreased to 56.5 kg and 21.1%, respectively, his muscle mass increased to 38.9 kg. Nutritional status evaluation indicated an improvement in the level of proteins such as transferrin, prealbumin, and retinol-binding protein, which reflected an increase in food intake. The FIM score improved from 49 to 105. No side effects were observed. The findings from this case suggest that ninjin'yoeito, which includes Astragalus root and Schisandra fruit, may be an effective treatment option for sarcopenia or frailty with appetite loss and impaired activities of daily living in aged patients.
Susac's Syndrome in a Patient Diagnosed with MS for 20 Years: A Case Report
Authors: Bijen Nazliel, Asli Akyol, Hale Zeynep Batur Caglayan, Irem Yildirim-Capraz, Ceyla Irkec
Journal: Case Rep Neurol Med (2014)

Susac's syndrome is an uncommon neurologic disorder of unknown cause. It has been described as a clinical triad of encephalopathy, hearing loss, and branch retinal artery occlusions. Clinically the diagnosis is difficult when the patient presents only a portion of a triad. We present a case with vision loss and sensorineural deafness and who had been diagnosed with MS for 20 years. Susac's syndrome is presumed to be an autoimmune endotheliopathy. Neurologic symptoms and signs are diffuse and multifocal, acute or subacute in onset, and progress during the active phase of the disease. In some patients the onset was stroke like and in others that of subacute dementia. Headache, often with migrainous features, was a prominent feature initially in more than one half of the patients. A high index of suspicion leading to correct diagnosis and early appropriate therapy may reduce the permanent sequel seen with this disease. Misdiagnosis is common. In patients in whom diagnosis and treatment are delayed permanent morbidity is higher in terms of visual loss, hearing loss, and neurologic debility. In patients in whom rapid diagnosis has led to early administration of immunosuppressive therapy, recovery can be almost complete.
Addition of aripiprazole to the clozapine may be useful in reducing anxiety in treatment-resistant schizophrenia
Authors: Aleksandar Chanachev, Nicolas Ansermot, Séverine Crettol Wavre, Ute Nowotka, Maria-Eleni Stamatopoulou, Philippe Conus, Chin B Eap
Journal: Case Rep Psychiatry (2011)
MeSH terms: Case Reports

There exist many case reports and studies on the antipsychotic augmentation by aripirazole in partial responders to clozapine, the most seem to be finding a slight difference in the PANSS and CGI scores after the aripirazole addition. The results of our report are compatible with those of other studies but, we have found a considerable antianxiety action in both of the cases. The 5HT1A agonism of aripirazole could be hypothesized as mechanism contributing to this effect.
Giant intraparietal inguinal hernia misdiagnosed as spigelian hernia in an old woman
Authors: Barbara Yordanis Hernandez Cervantes, Radisnay Guzmán Lambert, Duniesky Martínez Lopez, Mariuska Rodríguez Gonzalez, Frank Edwin
Journal: Pan Afr Med J (2020)
Keywords: intraparietal inguinal hernia, spigelian hernia, giant inguinal hernia
MeSH terms: Hernia, Inguinal / diagnosis, Hernia, Ventral / diagnosis, Herniorrhaphy / methods, Case Reports, Aged, 80 and over, Diagnostic Errors, Female, Hernia, Inguinal / surgery, Humans, Polypropylenes, Surgical Mesh, Polypropylenes

Intraparietal inguinal hernias are a rare variant of inguinal hernia in which the hernia sac lies between the layers of the abdominal muscles. Intraparietal inguinal hernias mimic Spigelian hernias clinically; the diagnosis presents superior difficulties than its treatment. We report a case of a giant intraparietal hernia misdiagnosed as a Spigelian hernia clinically. The patient was 83 years old woman presented with complain of a large swelling over right abdomen for around 25 years. The patient had a huge mass of 25 x 30 cm occupying right flank, right lumbar region extending up to the umbilicus and inguinal region, partially reducible with gurgling sounds. Surgery started with transversal incision over the mass, it was found to be an interstitial variety of intraparietal inguinal hernia with a long viable segment of the small bowel with their mesentery as content of the sac. Hernioplasty with a polypropylene mesh was achieved satisfactorily. The patient was discharged on third postoperative day without complications. It is challenging to diagnose intraparietal hernias preoperatively; intraoperative findings defined its definitive diagnosis and its surgical technique.
Stenting the Superior Petrosal Sinus in a Patient With Symptomatic Superior Semicircular Canal Dehiscence
Authors: Eugen C Ionescu, Aurelie Coudert, Pierre Reynard, Eric Truy, Hung Thai-Van, Aicha Ltaief-Boudrigua, Francis Turjman
Journal: Front Neurol (2018)
Keywords: endovascular treatment, pulsatile tinnitus, semicircular canal dehiscence, superior petrosal sinus, third window lesions
MeSH terms: Case Reports

Patients presenting superior semicircular canal dehiscence (SSCD) can experience symptoms such as conductive hearing loss, pulsatile tinnitus, autophony, and pressure-induced vertigo. Decreased cervical vestibular-evoked myogenic potentials (cVEMPs) thresholds and high-resolution computed tomography (HRCT) of the petrous bone are essential for diagnosis of SSCD syndrome. We report the case of a 43-year-old man suffering from constant right pulsatile tinnitus, intermittent autophony, and unsteadiness induced by physical exercise. An SSCD by the superior petrosal sinus (SPS) was confirmed on the right side by axial HRCT of the temporal bone reformatted in the plane of Pöschl and ipsilateral abnormally low elicited cVEMPs. Treatment options were discussed with the patient since the pulsatile tinnitus progressively became debilitating. Two options were considered: surgery or a new endovascular treatment; the patient chose the latter option. After stenting the right SPS, the intensity of the pulsatile tinnitus dramatically decreased. As there was no complication the patient was discharged at Day 1. The other symptoms improved progressively. By the 60-day follow-up visit the patient only reported a slight tinnitus worsened by physical exercise. Angiographic follow-up at 5 months confirmed the patency of the SPS. Stenting the SPS in patients with SSCD by the SPS appears to be an alternative to the existing surgical treatments.
Mandibular ameloblastoma treated by bone resection and immediate reconstruction
Authors: José Raphael de Moura Campos Montoro, Marconi Gonzaga Tavares, Daniel Hardy Melo, Rosemeire de Lordo Franco, Francisco Veríssimo de Mello-Filho, Samuel Porfírio Xavier, Alexandre Elias Trivellato, André Silva Lucas
Journal: Braz J Otorhinolaryngol (2008)
MeSH terms: Ameloblastoma / surgery, Dental Implantation, Endosseous, Mandibular Neoplasms / surgery, Case Reports, Bone Transplantation, Humans, Male, Middle Aged, Osteotomy, Plastic Surgery Procedures, Treatment Outcome

Multicystic ameloblastoma mainly affects adult patients between the third and seventh decades of life, frequently in the posterior region of the mandible. The resection of a mandible segment without adequate reconstruction produces serious esthetic and functional sequelae leading to a loss of quality of life. The objective of this study is to show that multidisciplinary treatment of ameloblastomas helps in total lesion excision associated with complete reconstruction of the damaged area. We present a 47-year-old male patient with an ameloblastoma in the posterior mandible who was treated with complete resection of a mandibular segment. Reconstruction, carried out during the same surgical procedure, was performed using an iliac crest bone graft fixed with titanium plates and screws. Rehabilitation was completed eight months later with teeth implants in the grafted area. The advantages of this procedure include recurrence risk reduction due to segmental resection, reliable mandibular reconstruction and less surgical procedures, allowing full rehabilitation within a shorter period of time.
May-Thurner Syndrome Presenting with Pelvic Hemorrhage in the Setting of Blunt Trauma
Authors: Dan F Laney 4th, Alexandra H Fairchild
Journal: Case Rep Vasc Med (2023)
MeSH terms: Case Reports

May-Thurner Syndrome is a vascular condition in which chronic compression of the left common iliac vein by the overlying right common iliac artery causes impaired venous return from the left lower extremity as well as possible development of pelvic varicosities. The condition typically presents with acute left lower extremity deep vein thrombosis or with signs and symptoms of pelvic or lower extremity venous insufficiency. In our patient, however, the presenting symptom was hemorrhage of pelvic varicosities in the setting of extensive pelvic fractures sustained during a motor vehicle collision. Acute hemorrhage in the setting of pelvic fractures is typically associated with the need for arterial angiography and possible embolization. This patient was instead treated with venography and stenting of her May-Thurner lesion which resulted in the resolution of her bleeding pelvic varicosities and improvement in her pre-existing pelvic and lower extremity venous symptoms.
Laproscopic treatment for small bowel bleeding after detection by double-balloon endoscopy: A case report
Authors: Shintaro Akabane, Takahisa Suzuki, Takao Hinoi, Yosuke Shimizu, Takeshi Sudo, Takashi Onoe, Kohei Ishiyama, Wataru Shimizu, Hirofumi Tazawa, Naoto Hadano, Toshihiro Misumi, Masato Kojima, Haruna Kubota, Junichi Zaitsu, Daiki Taniyama, Kazuya Kuraoka, Hirotaka Tashiro
Journal: Int J Surg Case Rep (2019)
Keywords: arteriovenous malformation (avm), double-balloon endoscopy, laparoscopic small bowel resection

Introduction:
The frequency of small bowel bleeding is relatively low and the process for the diagnosis and treaVtment remains difficult. Here, we report a case of massive small bowel bleeding due to arteriovenous malformation (AVM), treated by a combination of double-balloon endoscopy and laparoscopic resection.
Presentation of case:
A 59-year-old man was admitted to our hospital due to a hemorrhagic stool. The patient presented transient hemorrhagic shock and contrast-enhanced CT revealed a hyper-vascularized tumor in the small bowel. India ink tattooing for the responsible lesion with double-balloon endoscopy was performed. The tattooed lesion was easily confirmed during the subsequent laparoscopic observation and segmental resection was done. Pathological examination showed arteriovenous malformation of the small bowel.
Discussion:
Prior to laparoscopic resection, the localization of the responsible area might be a significant consideration when the lesion is invisible. Endoscopic marking with DBE enables intraluminal detection and laparoscopic observation from the serosal side.
Conclusion:
Preoperative marking with the use of double-balloon endoscopy followed by laparoscopic resection might be an optimal option for the treatment of massive small intestinal bleeding.
Rogue-elephant-inflicted panfacial injuries: a rare case report
Authors: Santosh Kumar Yadav, Suraksha Shrestha, Srijana Mishra Sapkota
Journal: Case Rep Dent (2012)

Attacks by elephants, the largest of the "large animals," produce many fatalities a year. Most attacks are provoked, although rogue elephants are occasionally responsible. Trampling, goring, tossing the individual with the trunk, or crushing with the knees produces the injuries. Injuries from encounters with large animals represent a significant health risk for rural communities. Wild-animal-inflicted maxillofacial injuries are rare, and limited literature is available describing their management. We present a case of severe maxillofacial injuries caused by the attack of a rogue elephant.
Length of Utterance, in Morphemes or in Words?: MLU3-w, a Reliable Measure of Language Development in Early Basque
Authors: Maria-José Ezeizabarrena, Iñaki Garcia Fernandez
Journal: Front Psychol (2018)
Keywords: basque language, mlu, bilingualism, complexity, early language development

The mean length of utterace (MLU), which was proposed by Brown (1973) as a better index for language development in children than age, has been regularly reported in case studies as well as in cross-sectional studies on early spontaneous language production. Despite the reliability of MLU as a measure of (morpho-)syntactic development having been called into question, its extensive use in language acquisition studies highlights its utility not only for intra- and inter-individual comparison in monolingual language acquisition, but also for cross-linguistic assessment and comparison of bilinguals' early language development (Müller, 1993; Yip and Matthews, 2006; Meisel, 2011). An additional issue concerns whether MLU should be measured in words (MLU-w) or morphemes (MLU-m), the latter option being the most difficult to gauge, since new challenges have arisen regarding how to count zero morphemes, suppletive and fused morphemes. The different criteria have consequences, especially when comparing development in languages with diverging morphological complexity. A variant of MLU, the MLU3, which is calculated out of the three longest sentences produced (MLU3-w and MLU3-m), is included among the subscales of expressive language development in CDI parental reports (Fenson et al., 1993, 2007). The aim of the study is to investigate the consistency and utility of MLU3-w and MLU3-m as a measure for (morpho-)syntactic development in Basque, an agglutinative language. To that end, cross-sectional data were obtained using either the Basque CDI-2 instrument (16- to 30-month-olds) or the Basque CDI-3 (30- to 50-month-olds). The results of analyzing reports on over 1,200 children show three main findings. First, MLU3-w and MLU3-m can report equally well on very young children's development. Second, the strong correlations found between MLU3 and expressive vocabulary in the Basque CDI-2 and CDI-3 instruments, as well as between MLU3 and both nominal and verbal morphology scales, confirm the consistency not only of MLU3 but also of the two Basque CDI instruments. Finally, both MLU3-w and MLU3-m subscales appear sensitive to input after age 2, which emphasizes their utility for identifying developmental patterns in Basque bilinguals.
A Case of Unusual Vascularization of Upper Abdominal Cavity' Organs
Authors: Natalia Mazuruc, Serghei Covantev, Olga Belic
Journal: Case Rep Vasc Med (2018)
MeSH terms: Case Reports

We describe a case report of multiple arterial variations of internal organs of upper abdominal cavity in a cadaver of 63-year-old female. There were several developmental variations of the vascular supply of the stomach, pancreas, spleen, and liver. There were several accessory arteries: left gastric, left hepatic, and posterior gastric artery as well as several arteries that had abnormal origin. The variations were discovered during macroscopical dissection at the department of human anatomy. It should be noted that multiple developmental variation can be common in clinical practice and clinicians should be aware of them during diagnostic and interventional procedures.
Predisposing and precipitating factors for delirium in community-dwelling older adults admitted to hospital with this condition: A prospective case series
Authors: Emmanuelle Magny, Hélène Le Petitcorps, Maria Pociumban, Zineb Bouksani-Kacher, Éric Pautas, Joël Belmin, Sylvie Bastuji-Garin, Carmelo Lafuente-Lafuente
Journal: PLoS One (2018)
MeSH terms: Delirium / etiology, Research Support, Non-U.S. Gov't, Aged, 80 and over, Delirium / diagnosis, Drug-Related Side Effects and Adverse Reactions / complications, Female, Hospitalization, Humans, Independent Living, Infections / complications, Male, Paris, Precipitating Factors, Prospective Studies, Water-Electrolyte Imbalance / complications

Background:
Factors associated with delirium among community-dwelling older adults have been poorly studied. Our aim was to describe the prevalence of predisposing and precipitating factors for delirium among patients admitted for delirium and to assess whether these factors were appropriately recognized at the first patient assessment at hospital.
Methods:
Consecutive community-dwelling individuals admitted to three geriatric acute care units with a confirmed initial diagnosis of delirium were prospectively included. An independent investigator recorded, using a predefined form, any acute medical condition considered by the attending geriatrician to be a precipitating factor, at the first patient assessment and at the end of his stay in acute care.
Results:
A total of 208 patients were included, 80.0% had a pre-existing cognitive or neurological disorder, or both. The most frequent precipitating factor found were infections (49.0% of all patients, mainly lung and urinary tract infections), followed by drugs (30.8%), dehydration (26.4%) and electrolytic disturbances (18.7%, mostly hyponatremia). 91% of patients had a cerebral imagery, but acute neurological conditions were found in only 18.3%. Fewer precipitating factors were found at first than at final assessment (1.4 (95%CI 1.3-1.6) versus 1.9 (95%CI 1.8-2.0) respectively, p<0.001). This difference was significant for all main categories of precipitating factors.
Conclusions:
Infections, followed by drugs and hydro-electrolytic disorders seem to be the most frequent precipitating factors for delirium in community-dwelling elderly individuals. Early diagnostic and management of precipitating factors in these patients should be improved, as a significant number of them are missed at the initial assessment.
Case report: Meningitis: a cause of reversible cerebral vasoconstriction syndrome?
Authors: Fida Oukhai, Valérie Domigo, Joseph Benzakoun, Michel Wolff, Anne Ducros, Jean-Louis Mas, David Calvet
Journal: Front Neurol (2023)
Keywords: csf inflammation, rcvs, meningitis, reversible cerebral vasoconstriction syndrome, thunderclap headache
MeSH terms: Case Reports

Introduction:
Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by thunderclap headache and reversible cerebral arteries vasoconstriction. The pathophysiology remains unclear, but many triggers were reported.
Case reports:
We reported two cases of patients with meningitis who developed RCVS confirmed by brain imaging. They presented clinical and CSF features of meningitis that are suspected to be infectious, but no agent was identified. Headache and artery irregularities were resolved with the improvement of CSF.
Conclusion:
These cases suggest that in the context of meningitis, modification or atypical headaches should lead to brain imaging to rule out RCVS. We hypothesized that CSF inflammation may trigger cerebral arteries vasoconstriction.
Posttransplant Lymphoproliferative Disorder Presenting as Testicular Lymphoma in a Kidney Transplant Recipient: A Case Report and Review of the Literature
Authors: Steve Omoruyi Obanor, Michelle Gruttadauria, Kayla Applebaum, Mohammad Eskandari, Michelle Lieberman Lubetzky, Stuart Greenstein
Journal: Case Rep Nephrol (2018)
MeSH terms: Case Reports

Posttransplant lymphoproliferative disorder (PTLD) is a malignancy caused by the immunosuppression that occurs after transplantation. It is primarily a nodal lesion but frequently it involves extranodal masses. Treatment is usually by reducing immunosuppressive therapy. Testicular lymphoma as PTLD is notably rare in documented literature and there is limited evidence of definitive treatment guidelines. This manuscript describes a patient who developed diffuse large B-cell lymphoma of his right testis one year following kidney transplantation. A diagnosis of PTLD was made and treatment with rituximab, locoregional radiotherapy, and intrathecal methotrexate in addition to the standard reduction of immunosuppression resulted in complete remission until now. We submit this case along with literature review of similar cases in the past and a review of specific peculiarities of our case with emphasis on our treatment plan to further the understanding of this diversiform disease.
Case report and literature review: Rare male aggressive angiomyxoma of the scrotum
Authors: Yue Chen, YaPing Wei, Hong Chang, ChunKai Yu
Journal: Front Surg (2022)
Keywords: aggressive angiomyxoma, local recurrence, male, scrotum, soft tissue tumor
MeSH terms: Case Reports

Aggressive angiomyxoma (AAM) is an uncommon locally infiltrative tumor that frequently occurs in the pelvic soft tissues of female patients; it has a high rate of local recurrence. However, AAM is extremely rare in males. Herein, we present the case of a 70-year-old man with a gradually enlarging painless mass in the scrotum. The patient underwent local excision of the scrotal AAM, with no local relapse after 17 months of follow-up. In addition to the present case, the clinicopathological features of males with AAM reported in literature (to the best of our knowledge) are discussed in this report. The literature review revealed that the gross morphology, clinical process, and histopathology of AAM in males resemble those of AAM in females. In particular, estrogen receptor/progesterone receptor has been shown to be expressed in male patients, which may provide an option for hormone therapy. Moreover, in males, a lower recurrence rate has been observed after surgery to remove the tumor. However, more data are needed to validate this observation. This report emphasizes the importance of considering AAM as the differential diagnosis of myxoid neoplasms in male genital areas.