OpenMed/multicare-articles huggingface dataset:
Clinical outcomes of Ahmed glaucoma valve implantation without fixation of a plate: The free plate technique
Authors: Han Min Lee, Kee Sup Park, Yoo Young Jeon, Woo Jin Kim, Nam Ho Lee, Kyoung Nam Kim, Chang-Sik Kim
Journal: PLoS One (2020)
MeSH terms: Glaucoma / surgery, Prosthesis Implantation / instrumentation, Comparative Study, Aged, Female, Glaucoma / physiopathology, Glaucoma Drainage Implants, Humans, Intraocular Pressure, Male, Middle Aged, Operative Time, Retrospective Studies, Surgical Fixation Devices, Treatment Outcome

Objective:
This study compared surgical outcomes between free plate Ahmed glaucoma valve (FPAGV) implantation without plate fixation and conventional Ahmed glaucoma valve (CAGV) implantation with plate fixation.
Methods:
A retrospective, comparative case series study. Patients with refractory glaucoma who underwent FPAGV or CAGV implantation and were followed >1 year were enrolled consecutively. We reviewed medical records, including data on postoperative intraocular pressure (IOP) and postoperative complications. The success rate and early postoperative hypertensive phase were compared between groups.
Results:
A total of 74 patients with CAGV implantations and 36 patients with FPAGV implantations were studied. The average follow-up periods were 23.3 ± 2.6 months (CAGV) and 22.8 ± 2.8 months (FPAGV; p = 0.424). The surgery time was significantly shorter in the FPAGV group than in the CAGV group (42.6 ± 4.1 vs. 47.3 ± 5.4 min; p < 0.001). Postoperative IOP at 1 week and 1 month were significantly lower in the FPAGV group than in the CAGV group (11.8 ± 3.6 and 14.0 ± 5.3 mmHg vs. 18.7 ± 5.5 and 22.2 ± 5.2 mmHg; p = 0.012 and p = 0.002, respectively). An early postoperative hypertensive phase occurred in 62 eyes, and the frequency was greater in the CAGV group (50 eyes) than the FPAGV group (12 eyes; p = 0.001). There was no significant difference in postoperative complications between the two groups (p = 0.735). The success rate was 84.2% in the FPAGV group and 80.6% in the CAGV group 24 months after surgery (p = 0.367).
Conclusion:
FPAGV implantation was associated with a shorter surgery time, without any change in the extent of IOP reduction or complication rate. This procedure may be considered a good alternative for CAGV implantation in patients with refractory glaucoma.
Successful Control of Massive Bleeding in a Child with Burkitt's Lymphoma via a Biosimilar Recombinant Activated Factor VII (AryoSeven™)
Authors: Kourosh Goudarzi Pour, Fatemeh Malek, Peyman Eshghi
Journal: Case Rep Hematol (2016)

We describe a case of a 4-year-old girl with Burkitt's lymphoma, who suffered from a massive gastrointestinal hemorrhage 3 days after chemotherapy. In spite of applying the common practice in correction of coagulopathy, thrombocytopenia persisted and bleeding became life-threatening. In the present case report, we report a successful control of bleeding with a single-dose administration of a biosimilar recombinant activated human factor VII (AryoSeven).
Diagnostic challenge of a deep minor salivary gland neoplasm
Authors: Vivian P Wagner, Manoela D Martins, Bruna Genari, Fernando B do Amaral, Antônio C Maciel, Marco A T Martins, Maria C Munerato
Journal: Case Rep Otolaryngol (2014)

Core needle biopsy represents a safe and cheap alternative diagnostic method to open biopsy and fine-needle aspiration cytology in head and neck tumors. There is little evidence in the literature about the use of core needle biopsy in minor salivary gland lesions. This single case report presents a 60-year-old woman with a painless swelling in the soft palate, breathing and swallowing difficulties, and a feeling of suffocation. Two open biopsies had inconclusive diagnosis and the lesion could only be assessed and diagnosed as pleomorphic adenoma through core needle biopsy. Recognizing the correct indication of core needle biopsy can benefit both health professionals and patients; thus, it is important to consider the possibility of performing this method to diagnose minor salivary gland tumors.
A Large Stone Within a Ureteroceles: A Diagnostic Pitfall and the Utility of Holmium Laser Deroofing as a Viable Surgical Option
Authors: Hanna Jamil El-Khoury, Hau Choong Aw, Daniel Gilbourd, Madalena Ian-Pim Liu
Journal: J Endourol Case Rep (2018)
Keywords: holmium laser, ureteral stones, ureteroceles
MeSH terms: Case Reports

We describe a case of a partial unilateral duplex system and ureterocele containing a 4 cm stone in a 66-year-old woman who presented with renal colic. Cystoscopic stone removal and deroofing of the ureterocele were performed and a ureteral stent was placed for a total of 6 weeks. Our case is unique as it highlighted the diagnostic pitfalls of ureteroceles, especially when obscured by a large calculus. We also described the use of a Holmium laser to simultaneously incise the ureterocele and fragment the calculus.
Aesthetic Rehabilitation of a Patient with Bruxism Using Ceramic Veneers and Overlays Combined with Four-Point Monolithic Zirconia Crowns for Occlusal Stabilization: A 4-Year Follow-Up
Authors: André Moreira, Filipe Freitas, Duarte Marques, João Caramês
Journal: Case Rep Dent (2019)
MeSH terms: Case Reports

Management of severe worn dentition in patients with bruxism is challenging as a result of the loss of tooth structure and occlusal vertical dimension, temporomandibular implications, tooth hypersensitivity, and masticatory or aesthetic impairment. This case describes the 4-year follow-up clinical evaluation of a full mouth tooth-supported rehabilitation made on a 66-year-old man with bruxism and tooth wear, with aesthetic complaints and compromised masticatory function. The prosthetic treatment was planned with a digital smile design and a mock-up technique for an aesthetic and minimally invasive approach using lithium disilicate pressed and layered veneers on anterior teeth, posterior CAD/CAM lithium disilicate overlays with facial coverage, and CAD/CAM monolithic zirconia crowns with facial feldspathic ceramic on maxillary and mandibular canines and first molars in order to ensure the occlusal stability at the increased occlusal vertical dimension. After 4 years of function, no complications were registered. The choice of an appropriate material for the rehabilitation of these patients is essential to improve treatment prognosis and should be guided by mechanical and aesthetical properties. The use of four-point occlusal stabilization with CAD/CAM high strength monolithic zirconia crowns combined with ceramic veneers and overlays appears to be a reliable treatment option that enhances aesthetics and minimizes the occurrence of ceramic fractures, ensuring the treatment prognosis and predictability.
Citalopram-induced sleep bruxism in a breastfed infant: A case report
Authors: Farzad Akbarzadeh, Ghazal Behravan, Farzaneh Modaresi, Mahboubeh Eslamzadeh
Journal: Front Psychiatry (2023)
Keywords: antidepressant, breastfeeding, bruxism, case report, citalopram, selective serotonin reuptake inhibitors (ssris), side effect
MeSH terms: Case Reports

Bruxism associated with antidepressant use is an under-recognized phenomenon. The use of citalopram has gained wide acceptance in the treatment of depression and anxiety disorders; however, the consumption of this medication during lactation and pregnancy has not been carefully characterized. There are limited studies about its side effects in the breastfeeding period. Here, we report a rare case of citalopram-induced sleep bruxism in a 9-month-old female breastfed infant whose mother used SSRI agent citaloporm for her anxiety disorder. Within 2 weeks of initiating her citalopram treatment, with a starting dose of 10 mg/day, the patient reported sleep bruxism in her infant. Thorough examinations of the infant were performed and no abnormal finding was reported. After ruling out other possible causes, the new-onset bruxism symptoms were attributed to the mother's recent use of citalopram, which was discontinued thereafter. The infant's symptoms of bruxism disappeared following the discontinuation of the medication by her mother. These findings and similar reports could draw more attention to bruxism or other possible symptoms in breastfed infants of mothers consuming psychotropic medications.
Laparoscopic hysterosacropexy in case of total uterus prolapse - case report
Authors: Paweł Szymanowski, Wioletta Katarzyna Szepieniec, Paweł Gruszecki, Isabel Netzer
Journal: Int J Surg Case Rep (2018)
Keywords: apical defect, hysteropexy, hysterosacropexy, uterus prolapse

Introduction:
Due to the many advances in laparoscopic surgery in urogynecology, various uterus-preserving techniques are increasingly being used in treatment. The following is a report of the case of a 43-year-old female with uterine prolapse POP-Q 4. This patient successfully underwent a minimally invasive laparoscopic procedure while preserving the uterus.
Presentation of case:
A 43-year-old caucasian female who was suffering from prolapse of the uterus POP-Q 4, overflow incontinence, dysuria and urinary retention was admitted to our department for the purpose of diagnostic tests and operative treatment. A gynecological examination showed a protruded hernial sac with the complete, normal sized uterus which had a thick appearance. The hernial sac also contained parts of the urinary bladder and intestines. Pelvic organ prolapse was classified as follows: prolapse of the uterus POP-Q 4. After repositioning the uterus with Kristeller specula we found a cystocele POP-Q 1 and a rectocele POP-Q 1. We also discovered a defect in the perineal region. Considering the patient's age and ASA Score 1, minimally invasive treatment was proposed: laparoscopic hysterosacropexy with perineoplasty.
Discussion:
Transabdominal sacrocolpopexy is associated with a low recurrence rate and also lower rates of dyspareunia when compared with vaginal sacrospinal colpopexy. Both sacrocolpopexy and implantation of anterior vaginal polypropylene mesh have better success rates and a lower rate of reoperation than vaginal uterosacral suspension. In level I defects, the right approach seems to be sacropexy. In this technique, the sacrouterine ligament is restored by recreating a ligament with polypropylene mesh.
Conclusion:
Laparoscopic sacrohysteropexy seems to be a good alternative in the treatment of uterus prolapse. It can also be viewed as a possible alternative for apical defect POP Q III or IV.
A Case of Type I Sirenomelia Complicated by Severe Oligohydramnios in the First Trimester
Authors: Atsushi Yoshida, Asumi Okumura, Masahiro Nakao, Ryo Suzuki
Journal: Case Rep Obstet Gynecol (2019)
MeSH terms: Case Reports

Sirenomelia is a very rare congenital anomaly. Type I is the mildest type, and the long bone structures are all normally present with only soft tissue fusion. We experienced a case of type I sirenomelia complicated by severe oligohydramnios. Because of severe oligohydramnios, ultrasonographic images were not very clear. The associated findings with sirenomelia (single umbilical artery and bilateral renal agenesis) were helpful for the prenatal diagnosis of this disease. Detailed sonographic examination of the fetus was thought to be necessary for the accurate prenatal diagnosis of sirenomelia.
Bilateral papilledema in a child with osteogenesis imperfecta
Authors: Selam Yekta Sendul, Cemile Ucgul Atilgan, Semra Tiryaki, Dilek Guven
Journal: Eye Vis (Lond) (2016)
Keywords: optical coherence tomography, osteogenesis imperfecta, papilledema, visual field defect
MeSH terms: Case Reports

Background:
To present a female child patient with osteogenesis imperfecta who had bilateral papilledema.
Case presentation:
A twelve-year-old girl with osteogenesis imperfecta was referred to our clinic. Bilateral best corrected visual acuity of the patient was 5/10 (corrected with +3.50 for right eye, +5.00 for left eye) with a standard Snellen scale at a distance of a 6 m. Anterior chamber, iris and lens examination of both of her eyes were unremarkable. In her fundus examination, bilateral stage 2 papilledema and the wrinkles in papillomacular area were noticed. Optical coherence tomography images revealed the macular pucker and thickening in the retinal nerve fibre layers of both eyes. Computed tomography images revealed that there were ossifications in the optic chiasma and occlusion in all periorbital sinus areas.
Conclusion:
Osteogenesis imperfecta is a rare, autosomal dominant connective tissue disorder characterised by bone fractures, deafness and blue sclera. We would like to draw attention to the clinical course of our patient with computed tomography, optical coherence tomography and visual field findings.
Oophoropexy for Recurrent Ovarian Torsion
Authors: Jennifer Hartley, Muhammad Akhtar, Edmond Edi-Osagie
Journal: Case Rep Obstet Gynecol (2018)
MeSH terms: Case Reports

A 31-year-old nulliparous patient presents with a three-day history of right sided colicky abdominal pain and associated nausea. This patient has previously presented twice with right sided ovarian torsion with the background of polycystic ovaries in the last two consecutive years. Blood tests were normal. Due to previous history, there was a high index of clinical suspicion that this may be a further torsion. Therefore, the patient was taken to theatre for a diagnostic laparoscopy and a further right sided ovarian torsion was noted. At this time, oophoropexy was performed to the uterosacral ligament to prevent further torsion in order to preserve the patients' fertility. In this article, we detail this case and also provide a discussion of ovarian torsion including risk factors, presentation, and current thoughts on management.
Umbilical Cord Patch Transplantation for Corneal Perforations and Descemetoceles
Authors: Hua-Tao Xie, Dan Zhao, Yang Liu, Ming-Chang Zhang
Journal: J Ophthalmol (2017)

Purpose:
To evaluate the clinical outcome of umbilical cord patch (UCP) transplantation for deep corneal ulcers with perforations and descemetoceles.
Methods:
In this retrospective, noncomparative, interventional case series, 11 eyes of 11 patients with corneal perforation or descemetocele were included. The thickness and microstructure of UCP were measured. All eyes were treated with UCP and amniotic membrane transplantation for corneal reconstruction. Corneal ulcer healing, corneal thickness, anterior chamber formation, and best-corrected visual acuity (BCVA) were recorded and analyzed.
Results:
The thickness of human UCP is 398.6 ± 102.8 μm (n = 5) with compact aligned fibers. The average age was 56.2 ± 15.8 (ranging from 22 to 75) years. The mean follow-up period was 7.1 ± 1.7 (ranging from 5 to 10) months. Four patients had descemetocele and 7 had perforation. The anterior chambers in all the 7 perforated corneas were formed at postoperative day 1. All patients regained a normal corneal thickness and smooth corneal surface within the first postoperative month. The vision improved in 10 eyes and remained unchanged in 1 eye. No recurrence nor side effects occurred during the follow-up.
Conclusions:
UCP can serve as an alternative material in the treatment of corneal perforations and descemetoceles. This treatment option is also beneficial in those countries with limited cornea donors and eye bank services.
Refractory ascites as a presenting feature of extramedullary plasmacytoma in an end-stage renal disease patient with HIV infection
Authors: Karim Soliman, Johann Herberth, Tibor Fülöp, Angie Duong, Rachel L Sturdivant
Journal: Clin Nephrol Case Stud (2019)
Keywords: ascites, dialysis, end-stage renal disease, extramedullary plasmacytoma, malignancy, peritoneal dialysis
MeSH terms: Case Reports

Refractory ascites as the only presenting feature of an extramedullary plasmacytoma complicating end-stage renal disease and HIV infection has not been described yet. We describe a case of a 39-year-old female with HIV-associated nephropathy manifesting with ascites formation after transition from peritoneal dialysis (PD) to hemodialysis (HD). Earlier on, she received cycler-assisted PD for 5 years uneventfully. A few weeks after HD transition, a striking refractory ascites developed requiring multiple paracenteses (5 - 7 L every second week). Serum protein electrophoresis showed hypoalbuminemia with only small amount of monoclonal IgG-κ at 0.30 g/dL. Serum immunofixation electrophoresis showed polyclonal immunoglobulins with polyclonal light chains. Both κ and λ light chains were increased, at 66.86 mg/dL (reference range: 0.33 - 1.94) and 18.55 mg/dL (reference range: 0.57 - 2.63), respectively, with a ratio of 3.6 (reference range: 0.26 - 1.65). However, an ascitic fluid analysis showed a marked increase in plasma cells with a κ : λ ratio greater than 5 : 1. Omental biopsy confirmed κ-restricted plasma cells. Multiple myeloma work-up with skeletal survey showed no evidence of focal osseous lesions, while bone marrow aspiration and biopsy also remained unremarkable. Accordingly, the diagnosis of omental extramedullary plasmacytoma with malignant ascites was confirmed. Conversion from PD to HD may unmask an underlying pathology favoring ascites formation.
Epithelial conjunctival neoplasias - the importance of an early diagnosis and optimal treatment
Authors: Laura Tabuenca Del Barrio, Marcos Mozo Cuadrado, Luiz Miguel Nova Camacho, Alicia Zubicoa Enériz, Miren Dolores Aranguren Laflin, Araceli Alcaine Soler
Journal: GMS Ophthalmol Cases (2020)
Keywords: cin, conjunctival malignancies, excisional biopsy, exenteration, radiotherapy, squamous cell carcinoma
MeSH terms: Case Reports

Objective: To emphasize the importance of an early diagnosis and an adequate treatment in conjunctival tumors. Methods: We present two clinical cases and compare the course of each case: one of conjunctival intraepithelial neoplasia (CIN) which took a positive course, and a fatal case of squamous cell carcinoma (SCC) with intraocular and orbital extension. Results: Epithelial conjunctival malignancies are one of the most prevalent ocular surface tumors. Among these, CIN are the most common. CIN have an excellent prognosis, given adequate treatment. However, when the diagnosis of CIN is late, the epithelial basement membrane will be affected, resulting in SCC. SCC may have poorer results due to its capacity to infiltrate near tissues and create distant metastasis. Conclusion: It is not common today to treat patients with orbital extension of SCC; however, it is crucial to note the importance of an early diagnosis of conjunctival malignancies. An early diagnosis is essential to prevent the transformation to other life-threatening types.
Unintentional injection to the bone with a pediatric epinephrine auto-injector
Authors: Mariam Ibrahim, Harold Kim
Journal: Allergy Asthma Clin Immunol (2018)
Keywords: anaphylaxis, bone injection, children, epinephrine auto-injector, needle length, skin-to-bone distance
MeSH terms: Case Reports

Background:
Skin-to-bone distance (STBD) in children prescribed a pediatric epinephrine auto-injector (EAI) for anaphylaxis is not commonly measured in practice. Recent evidence suggests that children with STBD less than the exposed needle length of available pediatric EAIs (dose: 0.15 mg, needle length: 12.7 mm) are at risk for unintentional injections to the bone during their use for an allergic emergency.
Case presentation:
Described here is a case of a female child with multiple food allergies prescribed a pediatric EAI (0.15 mg EpiPen Jr®) who experienced an unintentional injection to her femur. The patient's STBD at the recommended injection site (vastus lateralis) was shorter than the needle length of her prescribed EAI (12.7 mm) at the time of the injury (age: 7, height: 122 cm; weight: 25 kg), even though her weight was within the indication for this EAI (15-30 kg). The patient and her family were made aware of the risk of unintentional bone injection at the time the EAI was prescribed.
Conclusions:
Some children, even those at an appropriate weight per the indication of available pediatric EAIs (0.15 mg), may be at risk for unintentional injections to the bone. The effects of an unintentional bone injection with an EAI can have lasting effects on a child, including pain. Healthcare providers who prescribe pediatric EAIs for any child should consider evaluating this risk, inform patients and parents of the risk, and take measures to potentially mitigate unintentional bone injections. For some children, an EAI with a shorter needle length may be a more appropriate choice of treatment for anaphylaxis.
Amitraz poisoning treatment: still supportive?
Authors: Nastaran Eizadi-Mood, Ali Mohammad Sabzghabaee, Farzad Gheshlaghi, Ahmad Yaraghi
Journal: Iran J Pharm Res (2011)
Keywords: amitraz, bradycardia, central nervous system, isfahan, miosis

Amitraz is a triazapentadiene, an α2 adrenergic agonist and a member of the amidine chemical family. A limited number of human intoxication cases have been published in the literature. Lack of a clear and specific protocol for the therapy of amitraz intoxication may make its successfully managed case reports useful and valuable for other clinical practitioners in poisoning departments. The case is about a 22 years old female, single, university student, ingested a glass of amitraz poison (about 100 mL of a 20% solution) as a suicidal attempt on 11:30 am which was about 3.5 h before her hospital admission. She found nausea, vomiting, and dizziness. Immediately, her family took her to a clinic near their house. At that clinic (13:30 pm) she had miosis and they did gastric lavage , one adult dose of activated charcoal (50 g) and referred her to our Poisoning Emergency Department, where she was managed supportively and successfully. Amitraz is a poisonous chemical which may cause central nervous system depression and also respiratory/cardiovascular symptoms as well. Several studies reported that using atropine for those amitraz poisoned patients with both miosis and bradycardia resolved the problem and recommend it as the first line of drug therapy when bradycardia occurs from vagal stimulation and atrioventricular block. Management of amitraz poisoning is still considered to be supportive and symptomatic. Although the effects of activated charcoal and cathartics have not been studied, they may still be considered for treatment.
Case Report: A Pancreatic Ductal Adenocarcinoma Patient With Concurrent Targetable Somatic Novel KANK1-ALK, UPP2-NTRK3 Fusion, and Pathogenetic Germline BRCA Mutation
Authors: Fan Meng, Le Lu, Yuan Tan, Qianqian Duan, Hongwei Lu
Journal: Front Oncol (2021)
Keywords: kank1-alk, pdac, upp2-ntrk3, next-generation sequencing, pathogenetic brca1 mutation
MeSH terms: Case Reports

Pancreatic ductal adenocarcinoma (PDAC) is presently one of the cancers with the worst survival rates. The current treatment options for PDAC are relatively scarce due to insufficient understanding of molecular characteristics and subtypes of PDAC. Based on next-generation sequencing (NGS), we firstly presented a case about a KRAS wild-type pancreatic ductal adenocarcinoma patient harboring a concurrent targetable rare somatic novel KANK1-ALK, UPP2-NTRK3 fusion, and pathogenetic germline BRCA mutation. These two novel fusion statuses were assayed by immunohistochemistry (IHC) and fluorescent in situ hybridization (FISH). Our findings demonstrated that comprehensive and systematic screening of PDAC for actionable genomic alteration may substantially improve the therapeutic prospects for a sizeable fraction of patients with PDAC. To improve the management of PDAC in an era of precision medicine, it is important to identify ALK or NTRK fusion-positive and pathogenic germline mutation subsets of patients who can benefit from targeted therapies.