OpenMed/multicare-articles huggingface dataset:
Chest pain and ST-segment elevation in a patient with polymyositis: a case report
Authors: Pavlos N Stougiannos, Dimitrios Z Mytas, Andreas A Katsaros, Apostolos T Kakkavas, Aristides E Androulakis, Ioannis E Kallikazaros, Dimitrios N Chrissos
Journal: Cases J (2009)

Background:
Cardiac involvement in patients with polymyositis is well-documented and includes myocarditis, coronary arteritis, pericarditis, valvular dysfunction and arrhythmias.
Case report:
There are only few reports of acute myocarditis in patients with polymyositis and, although it usually follows a chronic, mild course, it may occasionally become life-threatening. We describe the case of a 36-year-old young woman suffering from polymyositis who presented with clinical signs and symptoms mimicking an ST Elevation Acute Coronary Syndrome. The atypical features of the pain, the young age of the woman, the lack of significant cardiovascular risk factors and the medical history of an autoimmune disease, led us to reconsider our initial diagnosis towards the presence of focal myocarditis.
Conclusion:
We describe our diagnostic approach and comment on our speculations and decisions about the treatment of such a life threatening event.
Laparoscopic Dismembered Repair in Two Patients with Retrocaval Ureter
Authors: Yuri Cavaleri, Giuseppe Farullo, Simona Gerocarni Nappo, Paolo Caione
Journal: European J Pediatr Surg Rep (2020)
Keywords: laparoscopy, retrocaval ureter, ureteroureterostomy
MeSH terms: Case Reports

Retrocaval ureter (RCU) or circumcaval ureter is a rare cause of congenital hydronephrosis. The surgical correction of RCU should be performed in all patients with obstruction and hydronephrosis symptoms, lumbar pain, urinary tract infections, hematuria, or urolithiasis. Traditionally, an open surgical approach was used for the treatment of RCU. Nowadays, surgical correction of these anomalies is performed using minimally invasive techniques. We report on two cases treated with our standardized laparoscopic technique using only three 5-mm trocars. The proposed approach could be considered as the first-line treatment for RCU.
Metaplastic breast carcinoma with extensive osseous differentiation
Authors: Shalaka Khade, Sudeep Khera, Poonam Elhence, Jeewan Ram Vishnoi
Journal: Autops Case Rep (2021)
Keywords: breast diseases, breast neoplasms, carcinoma, ductal, breast
MeSH terms: Case Reports

Metaplastic breast carcinoma is a rare subtype of invasive breast carcinoma. Metaplastic carcinoma with osseous differentiation is exceptionally uncommon. Because of the heterogenous microscopy of the lesion, various clinical and radiological features are observed, leading to diagnostic difficulty. Herein, we present a case of a 43-year-old female with a recurrent breast lump, who was clinically diagnosed as a phyllodes tumor. However, histopathological examination revealed metaplastic carcinoma with extensive osseous differentiation.
A Case of Sarcoidosis Associated With Anti-Tumor Necrosis Factor Treatment
Authors: Ayse Baha, Cigdem Hanazay, Nurdan Kokturk, Haluk Turktas
Journal: J Investig Med High Impact Case Rep (2015)
Keywords: anti-tnf-α treatment, psoriasis, pulmonary sarcoidosis

Sarcoidosis is a systemic chronic granulomatous disease of unknown etiology. It predominantly involves the lungs but can affect many organs or tissues in the body, such as the lymphatic system, skin, eyes, and liver. Typical histopathological lesions are noncaseating granulomas in the affected organ or tissue. Indications, type of treatment, and duration of sarcoidosis treatment is currently debated. Despite studies showing that anti-tumor necrosis factor-α (TNF-α) treatment can successfully be used in refractory sarcoidosis, there are some case reports regarding the development of sarcoidosis with these agents. There have been reports of 47 anti-TNF-associated cases of sarcoidosis until 2012. The patient is a 54-year-old Caucasian male. During routine examinations of the patient who had been followed for psoriasis vulgaris for 20 years and who had been on several anti-TNF regimens thereafter, new pulmonary pathologies due to sarcoidosis were detected. We present here a case of sarcoidosis that developed after infliximab treatment and showed obvious radiologic regression with discontinuation of treatment. During anti-TNF treatment, it should be kept in mind that autoimmune and granulomatous diseases may develop and particular care should be given to patient follow-ups.
Aggressive approach in a case of cancer cervix with uremia
Authors: Mg Janaki, S Mukesh, Tr Arul Ponni, S Nirmala
Journal: Indian J Palliat Care (2010)
Keywords: carcinoma cervix, chemotherapy, radiotherapy, renal failure
MeSH terms: Case Reports

Carcinoma of cervix is the most common cancer in developing countries. Majority of them present in locally advanced stages. A 36-year-old lady presented with bleeding and white discharge per vagina since four months, vomiting and reduced urine output since two weeks. Patient had an exophytic cervical growth. Investigation revealed elevated serum creatinine. Patient received single fraction radiation and underwent percutaneous nephrostomy. At one month follow-up, serum creatinine returned to almost normal level. Patient underwent bilateral ante grade stenting and completed concurrent chemoradiotherapy. In selected subsets of patients, aggressive management offered longer palliation and good quality of life.
High Molecular Weight ACTH-Precursor Presence in a Metastatic Pancreatic Neuroendocrine Tumor Causing Severe Ectopic Cushing's Syndrome: A Case Report
Authors: Roopa Mehta, César Ernesto Lam-Chung, José Miguel Hinojosa-Amaya, Paola Roldán-Sarmiento, Maria Fernanda Guillen-Placencia, Gerladine Villanueva-Rodriguez, Oscar Alfredo Juarez-Leon, Jefsi Leon-Domínguez, Mariana Grajales-Gómez, Jose Luis Ventura-Gallegos, Andrés León-Suárez, Francisco J Gómez-Pérez, Daniel Cuevas-Ramos
Journal: Front Endocrinol (Lausanne) (2020)
Keywords: acth, case report, cushing syndrome, ectopic, neuroendocrine tumor
MeSH terms: ACTH Syndrome, Ectopic / etiology, Adrenocorticotropic Hormone / blood, Neuroendocrine Tumors / complications, Pancreatic Neoplasms / complications, Case Reports, ACTH Syndrome, Ectopic / blood, ACTH Syndrome, Ectopic / pathology, Female, Humans, Middle Aged, Neuroendocrine Tumors / blood, Neuroendocrine Tumors / pathology, Pancreatic Neoplasms / blood, Pancreatic Neoplasms / secondary, Adrenocorticotropic Hormone

Ectopic ACTH-secretion causing Cushing's syndrome is unusual and its diagnosis is frequently challenging. The presence of high-molecular-weight precursors throughout pro-opiomelanocortin (POMC) translation by these tumors is often not reported. We present the case of a 49-year-old woman with a 3-month history of proximal muscular weakness, skin pigmentation, and weight loss. Upon initial evaluation, she had a full moon face, hirsutism, and a buffalo hump. Laboratory workup showed hyperglycemia, hypokalemia and metabolic alkalosis. ACTH, plasma cortisol, and urinary free cortisol levels were quite elevated. Serum cortisol levels were not suppressed on dexamethasone suppression testing. An octreo-SPECT scan showed enhanced nucleotide uptake in the liver and pancreas. Transendoscopic ultrasound-guided biopsy confirmed the diagnosis of a pancreatic ACTH-secreting neuroendocrine tumor (NET). Surgical excision of both pancreatic and liver lesions was carried out. Western blot analysis of the tumor and metastases revealed the presence of a high-molecular-weight precursor possibly POMC (at 30 kDa) but not ACTH (normally 4.5 kDa). ACTH-precursor secretion is more frequent in ectopic ACTH-secreting tumors compared with other causes of Cushing's syndrome. Hence, the measurement of such ACTH precursors warrants further evaluation, especially in the context of ACTH-dependent hypercortisolism.
Cervicomediastinal giant cystic hygroma: a case report
Authors: Omer Karakas, Ekrem Karakas, Fatima Nurefsan Boyaci, Murat Yildizhan, Songul Demir, Mehmet Akif Saglam, Nesat Cullu
Journal: J Clin Med Res (2013)
Keywords: cystic hygroma, mri, mediastinum, neck
MeSH terms: Case Reports

Cystic hygroma is a rare congenital malformation of the lymphatic system. It is most frequently detected in the head and neck region. Ultrasonography is performed as the first step for radiological diagnosis of these lesions. Magnetic resonance imaging provides important information for diagnosis and to guide treatment. In this paper, a case is reported of cervicomediastinal large cystic hygroma in a male infant.
Left Colon Diverticulitis Presenting as Perforated Lumbar Abscess: A Case Report and Review of the Current Literature
Authors: Daniel Paramythiotis, Konstantinia Kofina, Vassileios N Papadopoulos, Antonios Michalopoulos
Journal: Case Rep Gastrointest Med (2015)

Diverticular perforation is a common complication of diverticulitis and can lead to the creation of abscesses. The presence of such abscesses on the abdominal wall is rare and can lead to misdiagnosis. We present the case of a patient with abdominal pain and the formation of a large left lumbar abscess due to perforation of a diverticulum of the left colon and our surgical treatment of choice with favorable results.
Spinal Anaesthesia for Cesarean Section in a Patient with Vascular Type Ehlers-Danlos Syndrome
Authors: Jeffrey M Carness, Mark J Lenart
Journal: Case Rep Anesthesiol (2018)
MeSH terms: Case Reports

We report the administration of spinal anaesthesia for cesarean delivery in a parturient with vascular Ehlers-Danlos syndrome. Parturients who genetically inherit this disorder are at risk for significant morbidity and mortality. Risks during pregnancy include premature labor, uterine prolapse, and uterine rupture. Additionally, such laboring parturients are at increased risk of hemodynamic volatility, vascular stress, and severe postpartum hemorrhage. Instrumented delivery and cesarean delivery bring additional risks. Nonpregnancy-related complications include excessive bleeding, intestinal rupture, cardiac valvular dysfunction, and arterial dissection. Despite the complexity of this condition, literature focusing on specific intraoperative anaesthetic management is sparse.
Brachial metastatic plexopathy as the inaugural manifestation of lung cancer: multimodality imaging
Authors: Bruno Coulier, Oswald Van Cutsem, Patrick Mailleux, Fabienne Richelle
Journal: BJR Case Rep (2016)
MeSH terms: Case Reports

Metastatic infiltration of a peripheral plexus, also named metastatic plexopathy (MP), often results in severe pain and muscular weakness. This rather rare event may have a dramatic impact on the quality of life of patients affected by cancer. We hereby report a rare case of painful MP of the left cervicobrachial plexus presenting as the inaugural manifestation of poorly differentiated large-cell lung carcinoma in a 53-year-old patient. This responsible lung carcinoma was fortuitously diagnosed during MRI of the brachial plexus (BP). Complementary cancer staging was completed by contrast-enhanced multidetector CT, 18-fludeoxyglucose-positron emission tomography/CT and colour Doppler ultrasound of the BP. Although MRI remains the gold standard method for imaging the BP, our reported case emphasizes the alternative diagnostic capabilities of contrast-enhanced multidetector CT and ultrasound and confirms the high specificity of 18-fludeoxyglucose-positron emission tomography/CT in distinguishing brachial MP from secondary radiation plexopathy.
Noninvasive Positive Pressure Ventilation against Reperfusion Pulmonary Edema following Percutaneous Transluminal Pulmonary Angioplasty
Authors: Kiyoshi Moriyama, Sayuri Sugiyama, Koji Uzawa, Mariko Kotani, Toru Satoh, Tomoko Yorozu
Journal: Case Rep Anesthesiol (2011)
MeSH terms: Case Reports

A 69-year-old man with chronic thromboembolic pulmonary hypertension (CTEPH) was on amblatory oxygen inhalation therapy (3 L/min) and scheduled for percutaneous transluminal pulmonary angioplasty (PTPA). The patient's New York Heart Association functional status was class III with recent worsening of dyspnea and apparent leg edema. Transthoracic echocardiography revealed right ventricular enlargement with mean pulmonary artery pressure of 42 mmHg. After PTPA, he was complicated with postoperative reperfusion pulmonary edema, and noninvasive positive pressure ventilation (NPPV) was applied immediately. Hypoxemia was successfully treated with 15 days of NPPV. Although mean pulmonary artery pressure was unchanged, his brain natriuretic peptide level decreased from preoperative 390.3 to postoperative 44.3 pg/dL. In addition, total pulmonary resistance decreased from preoperative 18 to postoperative 9.6 wood unit·m(2). The patient was discharged on day 25 with SpO(2) of 95% on 5 L/min of oxygen inhalation. Because pulmonary edema is a postsurgical life-threatening complication following PTPA, application of NPPV should be considered.
Making mapping matter: a case study for short project international partnerships by global public health students
Authors: Rosemary Wyber, James R Potter, Jennifer B Weaver
Journal: Glob Health Action (2014)
Keywords: gis, education, global, mapping, sanitation
MeSH terms: Internationality, Public Health / education, Students, Public Health, Curriculum, Geography, Humans, India / epidemiology, Maps as Topic, Sanitation / methods, Sanitation / statistics & numerical data

Background:
A large number of global public health students seek international experience as part of their academic curriculum. These placements are often short, given the constraints of cost and time available within the academic calendar. In contrast to international electives for clinical students there are few published guidelines on practical, ethical or feasible projects. This paper describes a ten-day sanitation mapping project in Mumbai, India and explores the broader implications for global public health student electives.
Methods:
Three graduate public health students conducted a geographic review of sanitation facilities in Cheeta Camp informal settlement, Mumbai. Forty-six toilet blocks with 701 individual seats were identified. The project was reviewed ethically, educationally and logistically as a possible model for other short-term international projects.
Conclusions:
Clearer guidelines are needed to support non-clinical placements by global public health students. Projects that are feasible, relevant and meaningful should be foster maximise benefit for learners and host communities.
Management of an intruded tooth and adjacent tooth showing external resorption as a late complication of dental injury: three-year follow-up
Authors: Ülkü Şermet Elbay, Mesut Elbay, Emine Kaya, Alper Sinanoglu
Journal: Case Rep Dent (2015)

Treatment and prognosis of intrusive luxation can vary depending on the age of the patient, type of dentition, stage of root development, and time and severity of the trauma. Some studies have demonstrated that intrusions of up to 3.0 mm have an excellent prognosis, whereas teeth with severe intrusion or teeth that are intruded more than 6.0 mm present an unfavorable prognosis because of the occurrence of inflammatory resorption and pulp necrosis. The aim of this case report is to present an 11-year-old male patient with complete intrusion of the permanent maxillary left lateral incisor, associated with the adjacent central tooth presenting external resorption, treated by immediate surgical repositioning and root canal treatment with a favorable prognosis. After long-term (3-year) clinical and radiographic follow-up, the teeth appeared normal and the patient was pleased with the outcome.
Endovascular treatment of an aortic traumatic double rupture
Authors: Domenico Attinà, Francesco Buia, Vincenzo Russo, Emanuele Pilato, Luigi Lovato, Roberto Di Bartolomeo, Maurizio Zompatori
Journal: J Cardiovasc Thorac Res (2015)
Keywords: aortic rupture, emergency, endovascular procedure, endovascular stent graft, thoracic aorta, trauma
MeSH terms: Case Reports

Traumatic thoracic aortic rupture is a life-threatening condition; aortic isthmus is the most common site of rupture, but in rare cases traumatic injury can localize elsewhere, such as at aortic arch or at the level of the diaphragm. In the past few years, endovascular treatment of traumatic aortic injury became a safe procedure, with lower mortality and complication, if compared with open surgery. We report a case of a 40-year-old-man admitted to emergency department after a violent car crash in which an aortic traumatic double rupture was successfully treated with two endovascular stent-grafts coverage.
Diabetic ketoacidosis presenting with pseudonormoglycemia in a 15-year-old girl with type 1 diabetes mellitus
Authors: Sinem Akbay, Arda Yel, Ülkü Yıldırımer, Şule Can, Bumin Dündar
Journal: J Clin Res Pediatr Endocrinol (2013)
MeSH terms: Diabetes Mellitus, Type 1 / complications, Diabetic Ketoacidosis / complications, Hypertriglyceridemia / etiology, Case Reports, Adolescent, Diabetes Mellitus, Type 1 / blood, Diabetic Ketoacidosis / blood, Diagnosis, Differential, Female, Humans, Hyperlipidemias / complications, Hypertriglyceridemia / diagnosis, Hypertriglyceridemia / drug therapy, Hypoglycemic Agents / therapeutic use, Insulin / therapeutic use, Treatment Outcome, Hypoglycemic Agents, Insulin

Pseudonormoglycemic diabetic ketoacidosis (DKA) is a rare condition and has been reported only in a few adult patients. We present a 15-year-old girl with a 9-year history of type 1 diabetes who presented with euglycemic and extreme hypertriglyceridemia. The acidosis and hypertriglyceridemia resolved with intravenous insulin therapy and rehydration. Hyperlipidemia was the apparent cause of pseudonormoglycemia in this patient. The findings in the present case demonstrate that also in children, DKA can rarely occur without abnormal blood glucose levels. Assessment of the acid-base status, urinary glucose, and ketone readings is therefore important in all diabetic patients who are unwell at admission and have normal glucose levels. In such patients, hyperlipidemia may cause pseudonormoglycemia. An awareness of this rare treatable life-threatening condition is important.
Iridoschisis: visual outcome in treated versus untreated eye
Authors: Eric Ruff, Nataliya Pokeza, Inci Dersu
Journal: GMS Ophthalmol Cases (2020)
Keywords: angle closure glaucoma, cataract surgery, iridoschisis
MeSH terms: Case Reports

A 67-year-old man was referred for iris color change. He was noted to have narrow angles with atrophic iris appearance and visually significant cataracts. The iris findings were consistent with iridoschisis. The patient was recommended to have cataract surgery. Unfortunately, he was lost to follow-up. One year later, he presented with chronic angle closure glaucoma on the right eye with very high pressure and very poor remaining vision. Left-eye vision was also compromised with cataract. Despite the presence of small pupil, abnormal iris stroma, and dense cataract, the patient underwent successful cataract surgery and achieved 20/20 vision post-operatively. Iridoschisis can cause substantial ocular morbidity if not treated timely.
Kaposi Sarcoma in an Immunocompetent Patient Treated With Paclitaxel
Authors: Sunakshi Sharma, Vikas Malgotra, Mashkoor Wani
Journal: Cureus (2023)
Keywords: kaposi sarcoma, kaposi sarcoma good immunity, kaposi sarcoma hiv negative, kaposi sarcoma in an immunocompetent patient, kaposi sarcoma paclitaxel
MeSH terms: Case Reports

Kaposi sarcoma (KS) is a rare multifocal tumor originating from the cells lining the blood vessels. It is characterized by vascular proliferation and is usually associated with immunosuppression due to multiple factors, including AIDS or organ transplantation. However, sporadic cases of KS have been reported in HIV-negative immunocompetent patients. Paclitaxel has shown efficacy and may be an alternative for the initial therapy of patients with KS. We report a case of KS in a 70-year-old Asian male who was HIV-negative, with no history of immunosuppression or homosexuality and a good response to treatment with Paclitaxel.
Ectopic pregnancy in the cervix: a case report
Authors: Mohammad R Mohebbi, Kurt A Rosenkrans, Eric E Luebbert, Tauhni T Hunt, Michael J Jung
Journal: Case Rep Med (2011)
MeSH terms: Case Reports

Cervical pregnancy is an extremely rare condition with potential grave consequences if not diagnosed and treated early enough. We present a case and an ultrasound image of early cervical ectopic pregnancy with a history of two previous cesarean sections who was successfully treated with suction curettage.
Organoid drug screening report for a non-small cell lung cancer patient with EGFR gene mutation negativity: A case report and review of the literature
Authors: Yuetian Pan, Hongshang Cui, Yongbin Song
Journal: Front Oncol (2023)
Keywords: cancer, case report, genetic analysis, lung cancer, organoid
MeSH terms: Case Reports

Patients with non-small cell lung cancer (NSCLC) who carry epidermal growth factor receptor (EGFR) mutations can benefit significantly from EGFR tyrosine kinase inhibitors (EGFR TKIs). However, it is unclear whether patients without EGFR mutations cannot benefit from these drugs. Patient-derived tumor organoids (PDOs) are reliable in vitro tumor models that can be used in drug screening. In this paper, we report an Asian female NSCLC patient without EGFR mutation. Her tumor biopsy specimen was used to establish PDOs. The treatment effect was significantly improved by anti-tumor therapy guided by organoid drug screening.
A Case of Hemophagocytic Lymphohistiocytosis Secondary to Disseminated Histoplasmosis
Authors: Ivan Columbus-Morales, Lucas Maahs, Sanam Husain, Stuart C Gordon, Kedar V Inamdar, Humberto C Gonzalez
Journal: Case Reports Hepatol (2020)
MeSH terms: Case Reports

Hemophagocytic lymphohistiocytosis (HLH) is a rare condition characterized by a pathologic immune dysregulation resulting in extreme inflammation. Clinical manifestations are varied but can include severe multiorgan failure and death. HLH has been associated with malignancies, autoimmune diseases, and infections, such as histoplasmosis. Histoplasmosis commonly has subclinical manifestations but can also present in its disseminated form. We present the case of an immunocompromised patient with worsening liver function caused by hepatic histoplasmosis that later triggered HLH with severe multiorgan dysfunction.
Cyclosporine is a potential curative treatment option for advanced thymoma
Authors: Yusuke Isshiki, Hiroaki Tanaka, Yoshio Suzuki, Yukihiro Yoshida
Journal: Exp Hematol Oncol (2017)
Keywords: advanced thymoma, cyclosporine, pure red cell aplasia
MeSH terms: Case Reports

Background:
Thymectomy can effectively cure most thymoma patients; however, patients with advanced thymoma typically require chemotherapy, which is associated with limited efficacy in this context. Here we provide the first report of a patient with recurrent thymoma who achieved complete remission (CR) using cyclosporine therapy.
Case presentation:
A 63-year-old woman who had undergone resection surgery for recurrent type B1 thymoma developed pure red cell aplasia (PRCA), and CT findings revealed thymoma recurrence. After the initiation of orally-administered cyclosporine, PRCA quickly resolved, and the thymoma disappeared without the administration of any anti-thymoma therapy. The patient has remained in CR for over 3 years using only cyclosporine.
Conclusions:
This is the first report describing the curative potential of cyclosporine for the treatment of advanced thymoma. Although the mechanism underlying this effect remains unclear, cyclosporine can become a less toxic and more cost-effective treatment option for thymoma compared with conventional therapy. Clinical trials are needed to confirm the therapeutic potential of cyclosporine as a new treatment option for thymoma.