OpenMed/multicare-articles huggingface dataset:
Surgical Treatment of Intraductal Papillary Neoplasm of the Bile Duct: A Report of Two Cases and Review of the Literature
Authors: Binjie Li, Zhiqiang Liu, Zhuo Meng, Mingyang Li, Weijun Tian, Quanyan Liu
Journal: Front Oncol (2022)
Keywords: clinical features, intraductal papillary neoplasm of the bile duct, mutation, prognosis, surgical treatment
MeSH terms: Case Reports

Intraductal papillary neoplasm of the bile duct (IPNB) is a rare bile duct tumor characterized by intraductal papillary or villous neoplasms covered by neoplastic epithelium with fine fibrovascular stalks in the dilated bile ducts (1). Its true etiology remains unknown. Herein, we report two cases of IPNB that underwent surgical resection. The first case was a 66-year-old male who complained of upper abdominal pain for three years. We found obstruction of the common bile duct and dilation of the intrahepatic and extrahepatic bile ducts after MRCP. Laparoscopic hepatic segmentectomy (S2, S3, S4), resection of the common bile duct, cholecystectomy, and hepaticojejunostomy were performed. The second case was a 67-year-old male with asymptomatic dilation of the intrahepatic duct. The patient underwent robot-assisted laparoscopic hepatic segmentectomy (S5, S6, S7, S8), resection of the common bile duct, hepaticojejunostomy and cholecystectomy.
Restorative Retelling for Processing Psychedelic Experiences: Rationale and Case Study of Complicated Grief
Authors: Débora González, Marc B Aixalà, Robert A Neimeyer, Jordi Cantillo, Donald Nicolson, Magi Farré
Journal: Front Psychol (2022)
Keywords: ayahuasca, grief, integration, psychedelic therapy, restorative retelling

Rationale:
Many psychedelic experiences are meaningful, but ineffable. Engaging in meaning-making regarding emerging symbolic content and changing previous schemas have been proposed as mechanisms of change in psychedelic therapy.
Objective:
Firstly, we suggest the implementation of a Restorative Retelling (RR) technique to process and integrate the psychedelic experience into autobiographical memory, in a way that fosters meaning-making. We also show how ayahuasca has the potential to evoke key psychological content in survivors, during the process of grief adjustment following the death of a loved one.
Methods:
The rationale for the implementation of RR to process psychedelic experiences and a case study of a woman suffering from Complicated Grief (CG) after her mother's suicide are presented.
Results:
Evaluations conducted before the ayahuasca experience and after RR suggest the effectiveness of ayahuasca and RR in reducing symptoms of CG and psychopathology.
Conclusion:
This case report illustrates an effective adaptation of the RR technique for processing the psychedelic experience. The significance of the study and its limitations are discussed.
Laparoscopic resection of retroperitoneal intra-psoas muscle schwannoma: A case report and extensive literature review
Authors: Awadh AlQahtani, Mohammed N AlAli, Safaa Allehiani, Sulaiman AlShammari, Hussein Al-Sakkaf, Maria A Arafah
Journal: Int J Surg Case Rep (2020)
Keywords: laparoscopic anterior approach, neurilemmoma, psoas muscle, review, schwannoma
MeSH terms: Case Reports

Introduction:
Soft tissue tumors of Schwann cells in either the peripheral or cranial nerves are known as schwannomas or also as neurilemmomas. Limited data exists regarding psoas muscle schwannoma in the literature. Therefore, we have done an extensive literature review and found a total number of 46 cases of intra-psoas schwannoma including our case, which are summarized in this article along with reporting our new case.
Presentation of case:
We report a very rare case of primary left intra-psoas muscle schwannoma in a 39-year-old Saudi gentleman, smoker with an unremarkable medical and surgical history. The patient presented to the emergency department with exacerbated chronic lower abdominal pain since almost 2 years. After conforming the diagnosis, the patient was admitted electively and underwent uneventful laparoscopic hand-assisted resection.
Discussion:
Schwannomas are neurogenic tumors which known to be solitary, benign, well circumscribed, encapsulated, and slow-growing tumors. Multiple imaging modalities are used to detect such a tumor. Although there is no consensus on the best surgical approach, endoscopic mini-laparotomy, laparoscopy (anterior [as in our case] or lateral), and robotic resection were reported with good outcomes.
Conclusion:
Retroperitoneal schwannoma and intra-psoas muscle variant are a rare entity, with slow growing rate and risk of malignant transformation. Therefore, high index of suspicion, good follow-up, and large-cohort studies are encouraged.
Chrysomya chani Kurahashi (Diptera: Calliphoridae), a blow fly species of forensic importance: morphological characters of the third larval instar and a case report from Thailand
Authors: Kabkaew L Sukontason, Tanin Bhoopat, Anchalee Wannasan, Narin Sontigun, Sangob Sanit, Jens Amendt, Chutharat Samerjai, Kom Sukontason
Journal: Forensic Sci Res (2018)
Keywords: chrysomya chani, forensic science, thailand, forensic entomology, larval morphology, identification

Blow flies are worldwide the most important insects from a forensic point of view. In Thailand, aside from the two most common species, Chrysomya megacephala (F.) and Chrysomya rufifacies (Macquart), Chrysomya chani Kurahashi was also found to be of forensic importance. We present a case of a human female cadaver in its bloated stage of decomposition, discovered at Pachangnoi Subdistrict, northern Thailand. Entomological sampling during the autopsy displayed an assemblage of numerous dipteran larvae. Macroscopic observations showed the coexistence of third instar larvae of the three blow flies C. megacephala, Chrysomya villeneuvi Patton, an unknown blow fly species and one muscid, Hydrotaea sp. The minimum post-mortem interval was estimated to be six days, based on the developmental rate of C. megacephala. The ID of the unknown larva, which is the focus of this report, was revealed later as C. chani by DNA sequencing, using a 1205 bp of cytochrome c oxidase subunit I (COI). The occurrence of C. chani on a human body revealed the need to analyse and describe the morphology of its immature stage, to enable forensic entomologists to identify this fly species in future cases. The morphological examination of the third instar was performed, revealing peculiar characteristics: protuberant tubercles encircling abdominal segments; 9-11 lobes on the anterior spiracle; six prominent pairs of tubercles along the peripheral rim of the eighth abdominal segment; a heavily sclerotized complete peritreme of the posterior spiracles. A key to differentiate the third instar of blow flies of forensic importance in Thailand is provided.
Vertebral cryptococcosis in an immunocompetent patient--a case report
Authors: Bachir Houda, Ammouri Wafa, Tazi Mezalek Zoubida, Adnaoui Mohamed, Aouni Mohamed, Harmouche Hicham
Journal: Pan Afr Med J (2011)
Keywords: c neoformans, cryptococcosis, morocco, vertebral
MeSH terms: Antifungal Agents / therapeutic use, Cryptococcosis / drug therapy, Spinal Diseases / microbiology, Case Reports, Aged, Cryptococcosis / diagnosis, Cryptococcus neoformans / isolation & purification, Female, Humans, Immunocompetence, Spinal Diseases / diagnosis, Spinal Diseases / drug therapy, Treatment Outcome, Antifungal Agents

We report an unusual case of 70 years old, immunocompetent woman who was diagnosed with vertebral cryptococcosis. The diagnosis was made on the basis of radiological and histological findings. The outcome was favorable under antifungal treatment.
Case Report: A novel EPAS1 mutation in a case of paraganglioma complicated with polycythemia and atrial septal defect
Authors: Haiyan Yang, Yue Chen, Kai Liu, Liming Zhao
Journal: Front Endocrinol (Lausanne) (2023)
Keywords: epas1, atrial septal defect, hypertension, paraganglioma, polycythemia
MeSH terms: Heart Septal Defects, Atrial / genetics, Heart Septal Defects, Atrial / pathology, Heart Septal Defects, Atrial / therapy, Paraganglioma / diagnosis, Paraganglioma / genetics, Paraganglioma / pathology, Paraganglioma / therapy, Polycythemia / genetics, Polycythemia / pathology, Polycythemia / therapy, Case Reports, Research Support, Non-U.S. Gov't, Female, Humans, Middle Aged, endothelial PAS domain-containing protein 1

Background:
Paraganglioma is a rare neuroendocrine tumor and is highly associated with hereditary susceptibility genes, often occurring as part of a genetic syndrome. The genetic heterogeneity of paraganglioma poses challenges in diagnosis, counseling, and clinical management.
Case summary:
We present the case of a 60-year-old woman with hypertension, atrial septal defect, and polycythemia, who experienced paroxysmal palpitations, sweating, headache, abdominal pain, nausea, and vomiting. Her blood pressure was severely unstable. Blood laboratory tests revealed elevated catecholamine levels, contrast-enhanced CT of her whole abdomen showed a round retroperitoneal mass with soft tissue density, and somatostatin receptor imaging (68Ga PET-CT) indicated a retroperitoneal mass with abnormally increased expression of somatostatin receptor. It is interesting to note that whole exome sequencing (WES) analyses on both blood and tumor samples revealed a novel EPAS1 mutation, specifically the c.2501A > G; p.Tyr834Cys variant, which has never been reported. The patient was diagnosed with paraganglioma and underwent successful Da Vinci robot-assisted laparoscopic resection of the retroperitoneal tumor. During a 3-month follow-up period, her blood pressure stabilized, and her symptoms significantly improved.
Conclusion:
This case reveals that the EPSA1 mutation may be the primary driver of paraganglioma complicated by atrial septal defect and polycythemia. Additionally, the utilization of Da Vinci robot-assisted laparoscopic surgery contributed to a favorable prognosis for the patient.
Malignant masquerade sclerosing mesenteritis: A case report and review
Authors: Adithya G K, Satya Prakash Jindal, Varun Madaan, Rigved Gupta, Vivek Tandon, Deepak Govil
Journal: Int J Surg Case Rep (2018)
Keywords: mesenteric fibrosis, mesenteric malignancy, mesenteritis

Mesenteric panniculitis (MP), also known as sclerosing mesenteritis (SM), retractile mesenteritis or mesenteric lipodystrophy, is a rarely diagnosed inflammatory condition of unknown etiology that involves the mesenteric adipose tissue. We are presenting a case of sclerosing mesenteritis which presented us with features suggestive of malignant lesion and turned out to be benign one. An elderly gentleman of 68 years male presented to us with history of nonprogressive pain abdomen since 2 months associated with low grade fever and on and off constipation. On evaluation with CECT he was found to have mesenteric mass probably malignant. PET/CT showed an FDG avid lesion suggestive of malignancy, requiring surgery. He underwent radical excision of mesentery with resection of corresponding bowel. Final histopathology report showed poorly defined lesion comprised of nodular, poorly defined proliferation of bland looking fibroblast like cells, which at places are lying in fascicles, in a background of dense fibrosis and mature fat cells, with prominent focal lymphocytic infiltrate, at place forming reactive follicles, suggestive of sclerosing mesenteritis. Now patient is on follow up for further therapy.
A tale of many tumors and one endocrine site: A case series of pituitary metastases
Authors: Zeinab Dabbous, Muna Mohamed, Silas Benjamin, Fiona Green, Hassoun Salman, Tarik Elhadd
Journal: Qatar Med J (2021)
Keywords: diabetes insipidus, endocrine tumors, metastatic breast cancer, metastatic lung cancer, panhypopituitarism, pituitary
MeSH terms: Case Reports

Background:
Metastases to the pituitary gland are extremely rare with an incidence rate reported from an autopsy series of 1.8%-12%, and only 20% was diagnosed clinically. Tumors that commonly metastasize are breast and lung tumors.
Case series:
We present a series of five cases, including four female patients and one male patient with metastatic cancer. Two women had metastatic small lung cancer and presented with diabetes insipidus (DI). Two women had metastatic breast cancer, of which one presented with DI and the other with panhypopituitarism. The male patient had bronchogenic adenocarcinoma and presented with DI.
Conclusion:
Our case series confirmed earlier reports that DI is the most common presentation of metastases to the pituitary gland.
Hypoparathyroidism, deafness and renal dysplasia syndrome caused by a GATA3 splice site mutation leading to the activation of a cryptic splice site
Authors: Catarina I Gonçalves, Josianne N Carriço, Omneya M Omar, Ebtesam Abdalla, Manuel C Lemos
Journal: Front Endocrinol (Lausanne) (2023)
Keywords: gata3, hdr syndrome, cryptic splice site, deafness, hypoparathyroidism, renal dysplasia, splice site mutation
MeSH terms: Deafness, Hypoparathyroidism / complications, Hypoparathyroidism / genetics, Case Reports, Research Support, Non-U.S. Gov't, Child, Female, GATA3 Transcription Factor / genetics, Humans, Mutation, RNA Splice Sites, RNA Splice Sites, GATA3 protein, human, GATA3 Transcription Factor, Barakat syndrome

The HDR syndrome is a rare autosomal dominant disorder characterised by Hypoparathyroidism, Deafness, and Renal dysplasia, and is caused by inactivating heterozygous germline mutations in the GATA3 gene. We report an 11-year-old girl with HDR syndrome caused by a heterozygous mutation located at the splice acceptor site of exon 5 of the GATA3 gene (NM_001002295.2: c.925-1G>T). Functional studies using a minigene assay showed that this splice site mutation abolished the normal splicing of the GATA3 pre-mRNA and led to the use of a cryptic splice acceptor site, resulting in the loss of the first seven nucleotides (TCTGCAG) of exon 5 in the GATA3 mRNA. These findings increase the understanding of the mechanisms by which GATA3 splicing mutations can cause HDR syndrome.
Hem-o-lok Clips Migration: An Easily Neglected Complication after Laparoscopic Biliary Surgery
Authors: Jun-Wen Qu, Gui-Yang Wang, Zhi-Qing Yuan, Ke-Wei Li
Journal: Case Rep Surg (2017)
MeSH terms: Case Reports

Clip migration into the common bile duct (CBD) is a rare but well-established phenomenon of laparoscopic biliary surgery. The mechanism and exact incidence of clip migration are both poorly understood. Clip migration into the common bile duct can cause recurrent cholangitis and serve as a nidus for stone formation. We present a case, a 54-year-old woman, of clip-induced cholangitis resulting from surgical clip migration 12 months after laparoscopic cholecystectomy and laparoscopic common bile duct exploration (LC+LCBDE) with primary closure.
Differential neural response to psychoanalytic intervention techniques during structural interviewing: A single-case analysis using EEG
Authors: Anna Buchheim, Otto F Kernberg, Nikolaus Netzer, Peter Buchheim, Corinna Perchtold-Stefan, Barbara Sperner-Unterweger, Fabian Beckenbauer, Karin Labek
Journal: Front Hum Neurosci (2023)
Keywords: eeg analysis, alpha power, clarification, confrontation, interpretation, psychoanalytic intervention techniques, structural interviewing

Background:
Previous studies detected changes in the electroencephalographic (EEG) signal as an effect of psychoanalytic interventions. However, no study has investigated neural correlates of specific psychoanalytic interventions in the EEG power spectrum yet. In the present case study, we contrasted three types of interventions (clarification, confrontation, and interpretation) and a neutral control condition during a structural psychoanalytic interview conducted while EEG was recorded.
Methods:
A 27-year-old male patient diagnosed with major depressive disorder and borderline personality disorder with recurrent suicidal and self-injurious behavior underwent a structural interview while recording EEG. Two independent experts selected by consensus the characteristic episodes of the four conditions (clarification, confrontation, interpretation, and neutral control) within the interview, which were included in the EEG analyses. Fast Fourier transformation (FFT) was applied to subsegments of the intervention type to analyze the EEG power spectra. Alpha and beta power from central, frontal, and parietal sites were considered in linear mixed-effects models with segments as a random factor with maximum-likelihood estimates due to the lack of balance in the length of the interview segments.
Results:
The interventions "interpretation" and "confrontation" showed a significantly lower alpha power compared with the control condition in the central electrodes. In the frontal and parietal sites of the alpha power and all beta power sites, the omnibus tests (full model/model without intervention) and comparisons relative to control conditions showed no significant overall result or failed significance after alpha error correction.
Conclusion:
Incisive interventions, such as confrontation with discrepancies and interpretation of unconscious intrapsychic conflicts, may have provoked temporary emotional lability, leading to a change in psychic processing akin to interference from external stimuli. This conclusion is consistent with the finding that interpretations, which are potentially the most concise interventions, had the strongest effects on alpha power. Using EEG during therapeutic psychoanalytic intervention techniques might be a helpful tool to evaluate differential responses to the psychotherapeutic process on a neural level. However, this single-case result has to be replicated in a larger sample and does not allow generalizations.
Choroidal nevus and polypoidal vasculopathy: case series
Authors: Karlos Ítalo S Viana, Pedro F Dalgalarrondo, Zelia Correa, Rodrigo Jorge
Journal: Int J Retina Vitreous (2020)
Keywords: antiangiogenic, autofluorescence, choroidal nevus, polypoidal choroidal vasculopathy, retinal pigmental epithelial detachment
MeSH terms: Case Reports

Background:
To report an association between choroidal nevus and polypoidal choroidal vasculopathy (PCV) in three patients.
Case presentation:
We have encountered 3 isolated patients in our center presenting with subretinal exudation and a choroidal nevus that were thoroughly evaluated by slit lamp biomicroscopy, fundus photos, Fluorescein angiography (FA), indocyanine green angiography (ICG), B-scan ultrasound, and optical coherence tomography (SD-OCT-Heidelberg). The classic features of choroidal neovascularization seen on PVC were present in all 3 patients, all of whom had a substantial response to intravitreous antiangiogenic agent. OCT, Fluorescein and ICG Angiography, and Fundus autofluorescence (FAF) revealed similar findings in all cases.
Discussion and conclusions:
We have identified a clinical pattern of PCV and choroidal nevus that can be diagnosed early using fluorescein angiography, ICG and OCT.
GJB1 Mutation-A Disease Spectrum: Report of Case Series
Authors: Jingwen Niu, Yi Dai, Mingsheng Liu, Yi Li, Qingyun Ding, Yuzhou Guan, Liying Cui, Liri Jin
Journal: Front Neurol (2020)
Keywords: gjb1, x-linked charcot-marie-tooth disease (cmtx1), case series, central nervous system, peripheral neuropathy, transient central nervous system symptoms
MeSH terms: Case Reports

Introduction: Patients with GJB1 mutations manifested as pure central nervous system (CNS) involvement without peripheral neuropathy have not been adequately reported. To expand the disease spectrum of GJB1 mutations, we report a case series. Methods: Eleven patients from 9 families with GJB1 mutations were reviewed. The clinical manifestations, electrophysiological studies, and gene tests were summarized. Results: Nine patients had peripheral neuropathy, one patient had both peripheral neuropathy and mild cognitive impairment, and one patient had recurrent episodic limbs weakness and aphasia with normal electrophysiological study, indicating CNS involvement only. Discussion: GJB1 mutations form a clinical spectrum, including most patients with peripheral nerve involvement, those with both peripheral neuropathy and CNS involvement, and patients with CNS involvement only.
Sweet Syndrome due to Myelodysplastic Syndrome: Possible Therapeutic Role of Intravenous Immunoglobulin in Addition to Standard Treatment
Authors: Harry H S Gill, Anskar Y H Leung, N J Trendell-Smith, C K Yeung, Raymond Liang
Journal: Adv Hematol (2010)
MeSH terms: Case Reports

We report an 82-year-old lady who developed sudden onset nodular and erythematous lesions and neutrophilia following an episode of urinary tract infection. Skin biopsy confirmed the diagnosis of Sweet syndrome. Response to the use of prednisolone alone was not satisfactory. The skin lesions however showed a sustained response to the regular use of intravenous immunoglobulin (IVIG) and prednisolone was slowly weaned off. Our case highlights the possible therapeutic role of IVIG in managing this condition.
Incidental radiological diagnosis of asymptomatic Abernethy malformations-two case reports
Authors: Ali Shah, Abdul Aziz, Amir Awwad, Greg Ramjas, Yutaro Higashi
Journal: BJR Case Rep (2016)
MeSH terms: Case Reports

The diagnosis of the rare congenital extrahepatic portosystemic shunts is of clinical significance because of the risk of hepatic encephalopathy; liver dysfunction; and associated cardiac, gastrointestinal, vascular, skeletal and genitourinary anomalies. This article describes two varying cases showing the same type of the extrahepatic congenital shunts (Type II). Both the patients were clinically asymptomatic. The first patient initially presented with unprovoked deep venous thrombosis and a staging CT scan was performed to identify any potential underlying malignancy. The second was a polytrauma patient in whom a congenital extrahepatic portosystemic shunt was identified on the CT scan performed to investigate the trauma-related injuries. The first case underwent hepatological investigations, including a fibroscan to rule out liver fibrosis, and was diagnosed as having a Type II congenital malformation, while the second case is under observation post recovery from his traumatic injuries and will be subsequently referred to the hepatology team in the future. Although uncommon, extrahepatic portosystemic shunts can cause significant morbidity and mortality, and all new cases diagnosed radiologically should be further investigated by referring them to a hepatologist.
Massive Subcutaneous Emphysema, Pneumoperitoneum, Pneumoretroperitoneum, and Pneumoscrotum following Endoscopic Retrograde Cholangiopancreatography in a Living Liver Donor
Authors: S Akbulut, B Isik, Y Karipkiz, S Yilmaz
Journal: Int J Organ Transplant Med (2018)
Keywords: biliary complication, duodenal perforation, ercp-related complication, living donor hepatectomy
MeSH terms: Case Reports

Despite having many advantages, living donor liver transplantation has not been adopted by western countries due to risk of nearly life-threatening complications after living donor hepatectomy (LDH). Herein, we aimed at presenting the management of a 19-year-old patient who suffered life-threatening complications after right lobe LDH. A multiple detector computed tomography (MDCT) revealed a bilioma at the cut surface of the remnant liver, for which a transhepatic drainage catheter was placed. Endoscopic retrograde cholangiopancreatography (ERCP) performed to decompress biliary tract, but the biliary tract could not be cannulized due to post-precut bleeding. On the next day, extensive crepitation was detected and MDCT showed subcutaneous emphysema, pneumoperitoneum, pneumoretroperitoneum, and pneumoscrotum (ERCP-related duodenal perforation?). However, the patient showed significant deterioration of physical examination findings, fever, and infectious parameters, and therefore was taken to the operating room. Kocher maneuver revealed no apparent duodenal perforation. Then, a 2-mm bile duct was found open at the caudate lobe, through which bile leaked. Then, common bile duct exploration and T-tube placement were performed, followed by suture closure of the bile orifice at the caudate lobe. Massive air previously identified completely disappeared one week after the operation.