OpenMed/multicare-articles huggingface dataset:
Magnetoencephalography STOUT Method Adapted to Radiofrequency Thermocoagulation for MR-Negative Insular Epilepsy: A Case Report
Authors: Kaiqiang Ma, Guoming Luan, Xiongfei Wang, Shen Luo, Lang Qin, Pengfei Teng, Yuguang Guan, Meng Zhao, Jing Wang, Mengyang Wang, Jia-Hong Gao
Journal: Front Neurol (2021)
Keywords: stout, insular epilepsy, magnetoencephalography, radiofrequency thermocoagulation, stereo-electroencephalography
MeSH terms: Case Reports

Epilepsy is one of the most challenging neurologic diseases confronted by human society. Approximately 30-40% of the worldwide epilepsy patients are diagnosed with drug-resistant epilepsy and require pre-surgery evaluation. Magnetoencephalography (MEG) is a unique technology that provides optimal spatial-temporal resolution and has become a powerful non-invasive imaging modality that can localize the interictal spikes and guide the implantation of intracranial electrodes. Currently, the most widely used MEG source estimation method for clinical applications is equivalent current dipoles (ECD). However, ECD has difficulties in precisely locating deep sources such as insular lobe. In contrast to ECD, another MEG source estimation method named spatio-temporal unifying tomography (STOUT) with spatial sparsity has particular advantages in locating deep sources. In this case study, we recruited a 5 year-old female patient with insular lobe epilepsy and her seizure recurred in 1 year after receiving the radiofrequency thermocoagulation (RF-TC) therapy. The STOUT method was adopted to locate deep sources for identifying the epileptic foci in epilepsy evaluation. MEG STOUT method strongly supported a stereo-electroencephalographic (SEEG)-guided RF-TC operation, and the patient reported a satisfactory therapeutic effect. This case raises the possibility that STOUT method can be used particularly for the localization of deep sources, and successfully conducted RF-TC under the guidance of MEG STOUT results.
Cardiac Tamponade from Purulent Pericarditis due to Cutibacterium acnes
Authors: Ardalon Farhat-Sabet, Robert Hull, Dustin Thomas
Journal: Case Rep Cardiol (2018)
MeSH terms: Case Reports

Purulent pericarditis is a potentially fatal disease with high mortality rates if untreated. Cutibacterium acnes (formerly Propionibacterium acnes) is an anaerobic bacteria that is ubiquitous in skin flora and is commonly thought of as a culture contaminant; however, it does have pathogenic potential. We present a case of purulent pericarditis secondary to C. acnes leading to cardiac tamponade. Initial stabilization and diagnosis were made via pericardiocentesis; afterward the patient underwent a pericardial window. Due to a severe penicillin allergy, he was successfully treated with a 14-day course of vancomycin. To our knowledge, this represents only the third published case of purulent pericarditis with cardiac tamponade caused by C. acnes and the first case treated with a 14-day course of vancomycin.
Femoral nerve injury as a complication of percutaneous simple renal cyst sclerotherapy with ethanol: a case report
Authors: Alireza Ashraf, Mohammad Yasin Karami, Aida Amanat
Journal: Case Rep Med (2012)
MeSH terms: Case Reports

Simple renal cysts are benign, common, and often asymptomatic disease in old age, sometimes treated with ethanol sclerotherapy. We report a case of iatrogenic femoral nerve injury following percutaneous injection of ethanol into a renal cyst under sedation. The percutaneous injection was guided by sonography. At the end of the procedure, the cyst ruptured so the patient progressed to loss of consciousness due to alcohol intoxication. Ethanol was damaged to the femoral nerve, so patient was developed with limping, numbness, and weakness in anteromedial aspect of the right thigh. To the best of our knowledge, this is the first report of femoral nerve injury caused by percutaneous simple renal cyst sclerotherapy with ethanol. This rare event has not been previously described, Physicians should be aware of the possibility of this complication.
Laparoscopic Radical Prostatectomy Performed in a Patient With Zinner's Syndrome: The First Case Described in the Literature
Authors: Theodoros Spinos, Ioannis Leotsakos, Ioannis Katafigiotis, Filippos Nikitakis, Markos Karavitakis
Journal: Cureus (2023)
Keywords: laparoscopic, prostate cancer, radical prostatectomy, surgical technique, zinner’s syndrome
MeSH terms: Case Reports

Zinner's syndrome is a rare congenital disorder presenting with unilateral renal agenesis or dysgenesis, ipsilateral seminal vesicle cysts, and ejaculatory duct obstruction. Treatment of this syndrome can be conservative or surgical. In this case report, we describe the case of a 72-year-old patient who was diagnosed with Zinner's syndrome and underwent laparoscopic radical prostatectomy for prostate cancer treatment. The peculiarity of our case was that the patient's ureter emptied ectopically into the left seminal vesicle, which was notably enlarged and multicystic in appearance. Although many minimally invasive procedures have been reported for treating symptomatic Zinner's syndrome, to our knowledge, this is the first reported case of prostate cancer in a patient with Zinner's syndrome who was treated with laparoscopic radical prostatectomy. Laparoscopic radical prostatectomy can be safely and efficiently performed in patients with Zinner's syndrome and synchronous prostate cancer by urological surgeons with extensive experience in laparoscopy in high-volume centers.
Candidemia Following Ureteric Stent Placement in a Patient With Type 2 Diabetes Treated With Canagliflozin
Authors: Rishi Raj, Jon Hendrie, Aasems Jacob, Derick Adams
Journal: Front Endocrinol (Lausanne) (2019)
Keywords: canagliflozin, candidemia, candiduria, diabetes mellitus, sodium-glucose co-transporter 2 inhibitors, ureteral stent
MeSH terms: Case Reports

A 38-year-old female patient with well-controlled type 2 diabetes mellitus treated with canagliflozin underwent ureteral stent placement for obstructive renal calculi. Ten days following ureteroscopy and ureteral stenting, she developed fevers and blood cultures grew Candida glabrata (C. glabrata). The patient was successfully treated with an extended course of broad-spectrum antibiotics and antifungal agents. The clinical presentation of candidemia is indistinguishable from bacteremia resulting in delay in diagnosis and treatment. Candiduria is commonly seen in patients with type 2 diabetes, however it rarely leads to candidemia in an otherwise healthy person following a relatively simple urologic procedure. Sodium-glucose co-transporter 2 (SGLT-2) inhibitors act by its glycosuric effect and further increases the risk of genitourinary candida infection. Urologic procedures may lead to bloodstream entry of the genitourinary fungal organisms and result in life-threatening fungemia. Our case emphasizes the importance of awareness of the increased risk of potentially life threatening fungemia in patients using SGLT-2 inhibitors to avoid delay in diagnosis and treatment.
A Neonate With MuSK Congenital Myasthenic Syndrome Presenting With Refractory Respiratory Failure
Authors: Yanhua Shen, Bo Wang, Xia Zheng, Wenwen Zhang, Hailan Wu, Mingyan Hei
Journal: Front Pediatr (2020)
Keywords: chinese, musk gene, congenital myasthenic syndrome, neonate, respiratory failure
MeSH terms: Case Reports

This was a Chinese neonatal congenital myasthenic syndromes case caused by muscle skeletal receptor tyrosine kinase gene mutations, which have not been recorded in the Human Gene Mutation Database. The newborn girl had refractory respiratory failure from birth to death, and failed extubation seven times. She had two heterozygous mutations: a non-sense mutation c.2062C>T (p.Q688X) inherited from father and a missense mutation c.2324T>C (p.F775S) inherited from mother, which was predicted pathogenic and harmful by bioinformatic softwares SIFT, PolyPhen_2 and REVEL. She positively responded to Neostigmine, but her parent quitted treatment when Pyridostigmine Bromide (2 mg/kg Q12 h) had been given for 8 days. She died 2 days after she was taken home by her parents on age of 56 days.
Malignant Gastrointestinal Neuroectodermal Tumor (GNET) with Prolonged Disease-Free Survival after Platinum-Based Chemotherapy
Authors: Daulath Singh, Mohammed K Atieh, Mark A Russell, Muaiad Kittaneh
Journal: Case Rep Oncol Med (2020)
MeSH terms: Case Reports

Malignant gastrointestinal neuroectodermal tumor (GNET) is a rare disease with a handful of cases described in literature. GNET has only become a well-known/widely accepted entity in the recent years, but it is still not listed in the database of rare diseases. Due to the rarity of disease, there are no guidelines on standard therapeutic approaches in the adjuvant or metastatic setting. Here, we describe a unique case of GNET with a 7-year disease-free survival following adjuvant cisplatin and etoposide chemotherapy. This is the longest disease-free survival that has ever been described in literature and may support using this combination in a larger cohort of patients in the context of a global clinical trial. We will also review the histopathologic features of GNET and potential therapeutic options in the metastatic setting.
Liver contusion in man reveals a Tako-tsubo cardiomyopathy without chest pain: reality or illusion?
Authors: Zine el Abidine Benali, Hatim Abdedaim, Driss Omari
Journal: Pan Afr Med J (2014)
Keywords: ecg, liver contusion, tako-tsubo cardiomyopathy, chest pain
MeSH terms: Contusions / complications, Contusions / diagnosis, Liver / injuries, Takotsubo Cardiomyopathy / diagnosis, Case Reports, Humans, Incidental Findings, Male, Middle Aged, Takotsubo Cardiomyopathy / complications

Tako-tsubo syndrome is very rare in male patients, often overlooked by practitioners in its atypical form painless, and who did not always a good prognostic, often revealed in a context of acute stress at any time in the hospital or outside, its pathophysiology remains to discuss, the diagnosis is greatly facilitated by imaging including echocardiography with apical ballooning. We relate this clinical case of a patient admitted to the ICU for a liver contusion with a diagnosis incidentally this syndrome.
Insulin amyloidosis: A case report
Authors: Arthur Dubernet, Maud Toulmonde, Magali Colombat, Cécile Hartog, Etienne Riviere
Journal: Front Med (Lausanne) (2023)
Keywords: amyloidosis, case report, hyperglycemia, insulin, type 1 diabetes
MeSH terms: Case Reports

Insulin amyloidosis is a rare form of localized amyloidosis due to insulin aggregation into subcutaneous amyloid fibrils. We describe the case of a 55 years old male with insulin-requiring type 1 diabetes presenting with two non-inflammatory intra-dermal nodules associated with local lymph node enlargement. Diagnosis was confirmed by Congo red coloration of the amyloid deposit and insulin protein identification on mass spectrometry. Insulin amyloidosis is a potential complication of repeated subcutaneous insulin injections. The main risk factor is the intrinsic characteristic of the insulin used. Insulin amyloidosis leads to systemic metabolic consequences such as chronic hyperglycemia or unpredictable hypoglycemia, as well as unesthetic cutaneous lumps or abscesses. Standard-of-care is yet to be defined but mainly rely on therapeutical education of insulin injections, while surgical excision is reported to improve glycemic control in some patients.
Psychomotor retardation with a 1q42.11-q42.12 deletion
Authors: Jialing He, Yingjun Xie, Shu Kong, Wenjun Qiu, Xiaoman Wang, Ding Wang, Xiaofang Sun, Deming Sun
Journal: Hereditas (2017)
Keywords: 1q42 deletion, genotype-phenotype correlation, microarray analysis, psychomotor retardation
MeSH terms: Chromosome Deletion, Chromosomes, Human, Pair 1 / genetics, Developmental Disabilities / genetics, Case Reports, Child, Preschool, Chromosome Banding, Humans, In Situ Hybridization, Fluorescence, Male, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide

A 1q42 deletion is a rare structure variation that commonly harbours various deletion breakpoints along with diversified phenotypes. In our study, we found a de novo 1q42 deletion in a boy who did not have a cleft palate or a congenital diaphragmatic hernia but presented with psychomotor retardation. A 1.9 Mb deletion located within 1q42.11-q42.12 was validated at the molecular cytogenetic level. This is the first report of a 1q42.11-q42.12 deletion in a patient with onlypsychomotor retardation. The precise break points could facilitate the discovery of potential causative genes, such as LBR, EPHX1, etc. The correlation between the psychomotor retardation and the underlying genetic factors could not only shed light on the diagnosis of psychomotor retardation at the genetic level but also provide potential therapeutic targets.
Regular, low-dose methadone for reducing breathlessness in people experiencing or at risk of neurotoxic effects from morphine: A single-center case series
Authors: Piotr Z Sobanski, David C Currow
Journal: Front Med (Lausanne) (2022)
Keywords: breathlessness, heart failure, methadone, morphine, opioids, palliative management

Breathlessness is a common symptom suffered by people living with advanced malignant and non-malignant diseases, one which significantly limits their quality of life. If it emerges at minimal exertion, despite the maximal, guidelines-directed, disease-specific therapies, it should be considered persistent and obliges clinicians to prescribe symptomatic, non-pharmacological, and pharmacological treatment to alleviate it. Opioids are recommended for the symptomatic treatment of persistent breathlessness, with morphine most extensively studied for this indication. It is extensively metabolized in the liver into water-soluble 3- and 6-glucuronides, excreted by the kidneys. In the case of advanced renal failure, the glucuronides accumulate, mainly responsible for toxicity 3-glucuronides. Some people, predominantly those with advanced renal failure, develop neurotoxic effects after chronic morphine, even when prescribed at a very low dose. A single-center case series of consecutive patients experiencing neurotoxic effects after long-term, low-dose morphine or at risk of such effects were transferred to methadone to avoid the accumulation of neurotoxic metabolites. Over the course of 4.5 years, 26 patients have been treated with methadone in the median dose of 3.0 mg/24 h p.o., for persisting breathlessness. Sixteen of them had been treated previously with an opioid (usually morphine) at the median dose of 7.0 mg/24 h (morphine oral daily dose equivalent). They were transferred to methadone, with the median dose of 3.0 mg/24 h orally (methadone oral daily dose equivalent), and the median morphine-to-methadone dose ratio was 2.5:1. All patients experienced a meaningful improvement in breathlessness intensity after methadone, by a median of 5 points (range 1-8) on the 0-10 numerical rating scale (NRS) in the whole group, and by 2 points (range 0-8) in those pretreated with other opioids, mainly morphine. Low-dose methadone can be considered an efficient alternative to morphine for reducing breathlessness in people experiencing neurotoxic effects or at risk of developing them following treatment with morphine.
Usefulness of intraoperative Indocyanine green video angiography to select the recipient artery for bypass surgery in arteriosclerotic occlusion of the middle cerebral artery: a technical case report
Authors: Hiroaki Matsumoto, Yasuhisa Yoshida
Journal: Chin Neurosurg J (2018)
Keywords: indocyanine green video angiography, recipient artery, superficial temporal artery-middle cerebral artery bypass
MeSH terms: Case Reports

Background:
In superficial temporal artery-to-middle cerebral artery (STA-MCA) bypass surgery, indocyanine green video angiography (ICG-VA) is usually used to verify bypass patency. Less-commonly reported is the ability to use this technique to evaluate candidate recipient vessels based on either collateral flow or identification of the distal branch of interest.
Case presentation:
An 82-year-old man presented with progressive cerebral infarction due to infarction of the M2 inferior trunk of the right middle cerebral artery. He underwent superficial temporal artery-middle cerebral artery bypass to prevent further ischemia 1 week after the initial stroke. In the surgery, M4 cortical arteries fed by the inferior trunk could not be identified as recipient arteries. Intraoperative ICG-VA showed delayed luminescence of some M4 arteries. Because the M4 arteries fed by the inferior trunk showed delayed retrograde flows from the anterior cerebral artery on preoperative digital subtraction angiography, the M4 arteries with delayed luminescence on ICG-VA were considered to be M4 arteries fed by the inferior trunk and selected as the recipient arteries.
Conclusions:
ICG-VA shows differences in flow speed as delayed luminescence. This finding may be useful for detecting target vessels.
Internal Jugular and Subclavian Vein Thrombosis in a Case of Ovarian Cancer
Authors: Hiroto Moriwaki, Nana Hayama, Shouko Morozumi, Mika Nakano, Akari Nakayama, Yoshiomi Takahata, Yuusuke Sakaguchi, Natsuki Inoue, Toshiki Kubota, Akiko Takenoya, Yoshiko Ishii, Haruka Okubo, Souta Yamaguchi, Tsuyoshi Ono, Toshiaki Oharaseki, Mamoru Yoshikawa
Journal: Case Rep Otolaryngol (2017)
MeSH terms: Case Reports

Central venous catheter insertion and cancer represent some of the important predisposing factors for deep venous thrombosis (DVT). DVT usually develops in the lower extremities, and venous thrombosis of the upper extremities is uncommon. Early diagnosis and treatment of deep venous thrombosis are of importance, because it is a precursor of complications such as pulmonary embolism and postthrombotic syndrome. A 47-year-old woman visited our department with painful swelling on the left side of her neck. Initial examination revealed swelling of the region extending from the left neck to the shoulder without any redness of the overlying skin. Laboratory tests showed a white blood cell count of 5,800/mm3 and an elevated serum C-reactive protein of 4.51 mg/dL. Computed tomography (CT) of the neck revealed a vascular filling defect in the left internal jugular vein to left subclavian vein region, with the venous lumina completely occluded with dense soft tissue. On the basis of the findings, we made the diagnosis of thrombosis of the left internal jugular and left subclavian veins. The patient was begun on treatment with oral rivaroxaban, but the left shoulder pain worsened. She was then admitted to the hospital and treated by balloon thrombectomy and thrombolytic therapy, which led to improvement of the left subclavian venous occlusion. Histopathologic examination of the removed thrombus revealed adenocarcinoma cells, indicating hematogenous dissemination of malignant cells.
Case Report: Post-COVID-19 Vaccine Recurrence of Guillain-Barré Syndrome Following an Antecedent Parainfectious COVID-19-Related GBS
Authors: Margherita Bellucci, Francesco Germano, Stefano Grisanti, Chiara Castellano, Francesco Tazza, Emanuela Maria Mobilia, Davide Visigalli, Giovanni Novi, Federico Massa, Silvia Rossi, Paolo Durando, Corrado Cabona, Angelo Schenone, Diego Franciotta, Luana Benedetti
Journal: Front Immunol (2022)
Keywords: covid-19 vaccine, guillain–barrè syndrome, autoimmune diseases, case report, ganglioside antibodies
MeSH terms: COVID-19 Vaccines / adverse effects, COVID-19 / complications, Guillain-Barre Syndrome / diagnosis, Guillain-Barre Syndrome / etiology, Case Reports, Research Support, Non-U.S. Gov't, Autoantibodies, Gangliosides, Humans, Immunoglobulin M / therapeutic use, Immunoglobulins, Intravenous / therapeutic use, Male, Middle Aged, SARS-CoV-2, Autoantibodies, COVID-19 Vaccines, Gangliosides, Immunoglobulin M, Immunoglobulins, Intravenous

Guillain-Barré syndrome (GBS) is an autoimmune neurological disorder often preceded by viral illnesses or, more rarely, vaccinations. We report on a unique combination of postcoronavirus disease 2019 (COVID-19) vaccine GBS that occurred months after a parainfectious COVID-19-related GBS. Shortly after manifesting COVID-19 symptoms, a 57-year-old man developed diplopia, right-side facial weakness, and gait instability that, together with electrophysiology and cerebrospinal fluid examinations, led to a diagnosis of post-COVID-19 GBS. The involvement of cranial nerves and IgM seropositivity for ganglioside GD1b were noteworthy. COVID-19 pneumonia, flaccid tetraparesis, and autonomic dysfunction prompted his admission to ICU. He recovered after therapy with intravenous immunoglobulins (IVIg). Six months later, GBS recurred shortly after the first dose of the Pfizer/BioNTech vaccine. Again, the GBS diagnosis was confirmed by cerebrospinal fluid and electrophysiology studies. IgM seropositivity extended to multiple gangliosides, namely for GM3/4, GD1a/b, and GT1b IgM. An IVIg course prompted complete recovery. This case adds to other previously reported observations suggesting a possible causal link between SARS-CoV-2 and GBS. Molecular mimicry and anti-idiotype antibodies might be the underlying mechanisms. Future COVID-19 vaccinations/revaccinations in patients with previous para-/post-COVID-19 GBS deserve a reappraisal, especially if they are seropositive for ganglioside antibodies.
Case report: Early onset Marin-Amat syndrome after receiving ChAdOx1 nCoV-19 vaccination
Authors: Ping-Feng Tsai, Ying-Jen Chen
Journal: Front Med (Lausanne) (2022)
Keywords: astrazeneca, bell's palsy, chadox1 ncov-19, facial synkinesis, vaccine
MeSH terms: Case Reports

While vaccination against COVID-19 is still ongoing, some rare adverse events temporally related to vaccinations have been reported, particularly with ChAdOx1 nCoV-19. Here, a 77-year-old male presented to our outpatient department with persistent ptosis of his left eye for 1 month. He initially received vaccination with ChAdOx1 nCoV-19 and developed symptoms of Bell's palsy 3 days later. He received a 14-day course of prednisolone, but the ptosis persisted. Marin-Amat syndrome was compatible with his symptoms of ptosis exacerbation during orbicularis oris exertion. A temporal correlation between ChAdOx1 nCoV-19 vaccination and Bell's palsy without infectious or autoimmune diseases was delineated. Further studies are needed to clarify the possible relationship between these two events.
Case Report: Clinical manifestation and dental management of Papillon-Lefèvre syndrome
Authors: Yasmin Mohamed Yousry, Amr Ezzat Abd El-Latif, Randa Youssef Abd El-Gawad
Journal: F1000Res (2018)
Keywords: palmoplantar keratosis, papillon – lefèvre syndrome, periodontitis, premature tooth loss
MeSH terms: Mouth, Edentulous, Papillon-Lefevre Disease, Periodontitis, Case Reports, Child, Preschool, Egypt, Humans, Male

Background: Papillon-Lefèvre syndrome (PLS) is considered a rare syndrome, which is characterized by the presence of palmar-plantar hyperkeratosis and aggressively progressing periodontitis that finally leads to premature loss of both deciduous and permanent teeth. Case report: A four-year-old Egyptian boy presented with a maternal complaint that her child suffers from early loss of many teeth, presence of loose teeth along with an asymptomatic swelling related to the upper anterior area. The patient was diagnosed with PLS. A symptomatic management and prevention program was followed and the swelling was excised; afterwards diagnosed as peripheral ossifying fibroma. Conclusion: Early recognition and intervention for patients with PLS is essential to avoid the threat of being edentulous if left unmanaged.