OpenMed/multicare-articles huggingface dataset:
Transtuzumab induced organizing pneumonia: a case report
Authors: Ajay Gupta, Louise Teo, Philip Masel, David Godbolt, Geoffrey Beadle
Journal: Springerplus (2016)
Keywords: interstitial, lapatinib, organizing pneumonia, steroids, transtuzumab

Background:
Patients with metastatic breast cancer often have pulmonary symptoms with varying aetiologies. Transtuzumab is an extremely important drug used in the treatment of Her 2 neu over-expressing breast cancers. In this report we describe a case of organizing pneumonia associated with use of transtuzumab in metastatic breast cancer. Only three such cases have previously been reported.
Case description:
A 43 year old lady with Her 2 neu 3+, estrogen and progesterone receptor positive, metastatic breast cancer was started on weekly transtuzumab and albumen bound paclitaxel. She was admitted with an episode of bilateral pneumonitis after her fourth dose of therapy. It was managed conservatively with antibiotics. Subsequently, single agent transtuzumab was administered resulting in an anaphylactoid reaction followed by worsening dyspnoea requiring hospitalization and oxygen support for 3 days.
Discussion and evaluation:
The pneumonitis warranted further investigations including bronchoscopy which were performed. Bronchoscopic biopsy was consistent with a diagnosis of organizing pneumonia. Transtuzumab was stopped and she was started on steroids (dexamethasone). She improved remarkably and was discharged home on hormonal therapy, lapatinib and tapering doses of steroids.
Conclusion:
Organizing pneumonia closely mimics infection or progressive disease and can be difficult to diagnose in the setting of malignancy. Correct diagnosis is of paramount importance since delay in treatment can result in significantly adverse patient outcomes.
Recurrent Bilateral Optic Neuritis Associated with Myelin Oligodendrocyte Glycoprotein Antibody: A Case Report from Nepal
Authors: Sangam Shah, Rajeev Ojha, Sanjeeta Sitaula, Dosti Regmi, Ragesh Karn, Bikram Prasad Gajurel, Reema Rajbhandari, Niraj Gautam, Sunanda Paudel, Aashish Shrestha
Journal: Case Rep Neurol Med (2021)
MeSH terms: Case Reports

Neuromyelitis optica spectrum disorder (NMOSD) is an immune-mediated inflammatory condition involving spinal cord and optic nerves. Diagnosis of NMOSD is done by aquaporin-4 antibody (AQP4) in patients with optic neuritis. Myelin oligodendrocyte glycoprotein (MOG) expressed on the oligodendrocyte cell surface and on the outermost cell surface of the myelin sheath may also be present in patients with NMOSD bilateral optic neuritis. Here, we describe a case of a thirty-nine-year-old-female with recurrent bilateral optic neuritis with positive anti-MOG antibody, and anti-MOG syndrome has not previously been reported from Nepal.
Clinicians' perspectives and experiences of providing cervical ripening at home or in-hospital in the United Kingdom
Authors: Cassandra Yuill, Mairi Harkness, Chlorice Wallace, Helen Cheyne, Mairead Black, Neena Modi, Dharmintra Pasupathy, Julia Sanders, Sarah J Stock, Christine McCourt
Journal: PLoS One (2023)
MeSH terms: Midwifery, Oxytocics, Research Support, Non-U.S. Gov't, Cervical Ripening, Female, Hospitals, Humans, Labor, Induced, Outpatients, Pregnancy, Oxytocics

Induction of labour, or starting labour artificially, is offered when the risks of continuing pregnancy are believed to outweigh the risks of the baby being born. In the United Kingdom, cervical ripening is recommended as the first stage of induction. Increasingly, maternity services are offering this outpatient or 'at home', despite limited evidence on its acceptability and how different approaches to cervical ripening work in practice. There is also a paucity of literature on clinicians' experiences of providing induction care in general, despite their central role in developing local guidelines and delivering this care. This paper explores induction, specifically cervical ripening and the option to return home during that process, from the perspective of midwives, obstetricians and other maternity staff. As part of a process evaluation involving five case studies undertaken in British maternity services, interviews and focus groups were conducted with clinicians who provide induction of labour care. The thematic findings were generated through in-depth analysis and are grouped to reflect key points within the process of cervical ripening care: 'Implementing home cervical ripening', 'Putting local policy into practice', 'Giving information about induction' and 'Providing cervical ripening'. A range of practices and views regarding induction were recorded, showing how the integration of home cervical ripening is not always straightforward. Findings demonstrate that providing induction of labour care is complex and represents a significant workload. Home cervical ripening was seen as a solution to managing this workload; however, findings highlighted ways in which this expectation might not be borne out in practice. More comprehensive research is needed on workload impacts and possible lateral effects within other areas of maternity services.
A patient with weakness and an abnormal chest radiograph: A case report
Authors: A van Straaten, J A Shaw, C F N Koegelenberg
Journal: Afr J Thorac Crit Care Med (2018)
Keywords: mediastinal mass, weakness
MeSH terms: Case Reports

A 40-year-old black male presented to ICU after intubation for airway protection due to rapid onset of neck weakness and swallowing difficulty. His chest radiograph showed an unusual mediastinal opacity for which a computer tomography (CT) scan was done, confirming a mediastinal mass.
Bilateral Carotid and Vertebral Artery Dissection from Blunt Trauma
Authors: Catherine Coss, Jeffrey Jones
Journal: Case Rep Emerg Med (2018)
MeSH terms: Case Reports

Carotid and vertebral artery injuries are rare following blunt trauma. They can, however, lead to severe consequences with a significant associated rate of stroke and intracranial hemorrhage, particularly if the diagnosis and treatment are delayed. We report a case of a 23-year-old female who presented to the Emergency Department with bilateral carotid and vertebral artery dissection following a motor vehicle collision (MVC).