OpenMed/multicare-articles huggingface dataset:
Sacroiliitis secondary to catheter-related bacteremia due to Mycobacterium abscessus (sensu stricto)
Authors: Chrislène Laurens, Geneviève Héry-Arnaud, Raphael Chiron, Eric Oziol, Hélène Jean-Pierre, Nicolas Bouzinbi, Philippe Vande Perre, Anne-Laure Bañuls, Sylvain Godreuil
Journal: Ann Clin Microbiol Antimicrob (2014)
MeSH terms: Bacteremia / complications, Bacteremia / diagnosis, Catheter-Related Infections / diagnosis, Mycobacterium / isolation & purification, Mycobacterium Infections / diagnosis, Sacroiliitis / diagnosis, Case Reports, Research Support, Non-U.S. Gov't, Adult, Bacteremia / microbiology, Bacteremia / pathology, Catheter-Related Infections / microbiology, Catheter-Related Infections / pathology, Cluster Analysis, Female, Genotype, Humans, Minisatellite Repeats, Multilocus Sequence Typing, Mycobacterium / classification, Mycobacterium / genetics, Mycobacterium Infections / microbiology, Mycobacterium Infections / pathology, Sacroiliitis / microbiology, Sacroiliitis / pathology

We describe a case of sacroiliitis secondary to catheter-related bacteremia due to Mycobacterium abscessus (sensu stricto). This case confirms that MultiLocus sequence typing and variable-number tandem-repeat methods are very robust techniques to identify the pathogen species and to validate molecular epidemiological links among complex M. abscessus isolates.
A Rare Case of Cardiogenic Shock Following Severe Multivessel Coronary Vasospasm
Authors: Reza Rahmani, Amirfarhangh Zand Parsa, Alborz Sherafati, Rouzbeh Kosari, Vahid Mohhamadi, Rizan Mohhamadi
Journal: J Tehran Heart Cent (2019)
Keywords: angina pectoris, variant, coronary vasospasm, shock, cardiogenic
MeSH terms: Case Reports, Retracted Publication

Prinzmetal's angina occurs following spasms in a single or multiple vascular beds, resulting in a typical chest pain and an ST-segment elevation in electrocardiography (ECG). It can lead to life-threatening arrhythmias and sudden cardiac death. We describe a 37-year-old woman who was admitted with a typical chest pain and hypotension. Her initial ECG showed an ST-segment elevation in the inferior and precordial leads. She was transferred to the catheterization unit, where coronary angiography illustrated multivessel spasms. The spasms were relieved with a nitroglycerin injection. She was discharged with stable hemodynamics 7 days later, and at 1 month's follow-up, no recurrent attack was detected.
Thoracic impalement injury by the barrel of a locally fabricated gun in 2 patients: case report
Authors: Solomon Ifeanyi Ukwuani, Abubakar Umar, Salisu Ismail, Abdullahi Abdulkarim Aitek, Ibrahim Galadima, Isah Abdullahi, Sulieman Kehinde Ayuba, Ray Bayo
Journal: Pan Afr Med J (2022)
Keywords: impalement, case report, chest injury, gun barrel
MeSH terms: Pneumothorax / surgery, Thoracic Injuries / surgery, Wounds, Penetrating / surgery, Case Reports, Humans, Thoracotomy

Thoracic impalement injuries are uncommon among civilians. When it occurs, it´s usually a severe and dramatic form of chest injury that requires immediate operative intervention. The common mechanisms usually encountered involves either a patient falling from a height onto a pole, being driven into a pole following ejection during a road traffic accident or being impaled when a spear/an arrow is thrown at the patient or from long fragments following a blast. Impalement by a retrograde ejected barrel of a gun during recoil is a very uncommon mechanism. We report 2 recently managed patients. The first patient presented with an overt impaling mass and an initially missed tension pneumothorax. The second patient had a covert impalement chest injury. Both patients had surgical interventions with satisfactory outcomes. Our report aims to highlight this unusual mechanism of thoracic impalement injury and the principles of management. We also want to emphasize the importance of adhering to the advanced trauma life support (ATLS) management algorithm, as immediately life-threatening conditions may be missed when exploratory thoracotomy is the only focus.
Case Report: Extensive Tumor Profiling in Primary Neuroendocrine Breast Cancer Cases as a Role Model for Personalized Treatment in Rare and Aggressive Cancer Types
Authors: Dörthe Schaffrin-Nabe, Stefan Schuster, Andrea Tannapfel, Rudolf Voigtmann
Journal: Front Med (Lausanne) (2022)
Keywords: extensive tumor profiling, personalized treatment, primary endocrine breast cancer, rare cancer therapy, targeted therapies
MeSH terms: Case Reports

Neuroendocrine breast cancer (NEBC) is a rare entity accounting for <0.1% of all breast carcinomas and <0.1% of all neuroendocrine carcinomas. In most cases treatment strategies in NEBC are empirical in absence of prospective trial data on NEBC cohorts. Herein, we present two case reports diagnosed with anaplastic and small cell NEBC. After initial therapies failed, comprehensive tumor profiling was applied, leading to individualized treatment options for both patients. In both patients, targetable alterations of the PI3K/AKT/mTOR pathway were found, including a PIK3CA mutation itself and an STK11 mutation that negatively regulates the mTOR complex. The epicrisis of the two patients exemplifies how to manage rare and difficult to treat cancers and how new diagnostic tools contribute to medical management.
Off-Label Use of Intravenous Immunoglobulin with Methylprednisolone to Treat Parsonage-Turner Syndrome in a United States Marine
Authors: Carissa M Sedlacek, Michael Leone, Adam D Foster, Amy Hinkelman
Journal: Case Rep Med (2021)
MeSH terms: Case Reports

Neuralgic amyotrophy (NA) also known as Parsonage-Turner syndrome is an inflammatory disorder of the brachial plexus characterized by sudden, acute onset of severe pain of the arm and/or shoulder followed by muscle weakness and sensory abnormalities. Although management may involve physical therapy, immunomodulatory drugs, and analgesics, there is nothing specific for the treatment of NA. Full functional recovery can take months to years, but recurrence and/or persistence of symptoms and disability are frequent. This case reports a 22-year-old male who recovered from NA within 3 months following treatment with 1000 mg of methylprednisolone and off-label use of 0.5 g/kg of intravenous immunoglobulins (IVIG) for four consecutive days. Three years later, the patient experienced soreness and paresthesia of the shoulder following a military shooting exercise, and 0.75 g/kg of IVIG and 1000 mg of MP were prescribed for 2 consecutive days resulting in complete recovery and no recurrences to date. EMG findings, 3.5-year postinitial treatment, revealed improvement in the brachial plexopathy. This provides support for the combined use of IVIG and glucocorticoids in the treatment of NA and highlights the need for further studies investigating whether this combined treatment regimen may accelerate recovery and improve long-term outcomes for patients diagnosed with NA.
Osteogenic sarcoma of the breast arising in a cystosarcoma phyllodes: a case report and review of the literature
Authors: Vinay Singhal, Chintamani, John M Cosgrove
Journal: J Med Case Rep (2011)

Introduction:
Primary tumors of the breast containing bone and cartilage are extremely rare, and an osteogenic sarcoma arising from a cystosarcoma phyllodes is exceptional.
Case presentation:
A 40-year-old Indian woman presented with a breast mass which was diagnosed as osteosarcoma of the breast on biopsy. Our patient was treated with a simple mastectomy after excluding the presence of skeletal primary and extra-mammary metastases. Final pathology showed a cystosarcoma phyllodes with signs of osteogenic sarcoma.
Conclusion:
Although osteogenic sarcomas of the breast are rare, they need to be distinguished from carcinosarcomas and metaplastic carcinomas as the management of the two differ.
A Case of Hyperacute Severe Thrombocytopenia Occurring Less than 24 Hours after Intravenous Tirofiban Infusion
Authors: Vineet Meghrajani, Nitin Sabharwal, Vinod Namana, Moustafa Elsheshtawy, Bernard Topi
Journal: Case Rep Hematol (2018)
MeSH terms: Case Reports

Thrombocytopenia is defined as a condition where the platelet count is below the lower limit of normal (<150 G/L), and it is categorized as mild (100-149 G/L), moderate (50-99 G/L), and severe (<50 G/L). We present here a 79-year-old man who developed severe thrombocytopenia with a platelet count of 6 G/L, less than 24 hours after intravenous tirofiban infusion that was given to the patient during a percutaneous transluminal coronary angioplasty procedure with placement of 3 drug-eluting stents. The patient's baseline platelet count was 233 G/L before the procedure. Based on the timeline of events during hospitalization and laboratory evidence, it was highly likely that the patient's thrombocytopenia was the result of tirofiban-induced immune thrombocytopenia, a type of drug-induced immune thrombocytopenia (DITP) which occurs due to drug-dependent antibody-mediated platelet destruction. Anticoagulant-mediated artefactual pseudothrombocytopenia was ruled out as no platelet clumping was seen on the peripheral blood smears. The treatment of DITP includes discontinuation of the causative drug; monitoring of platelet count recovery; or treatment of severe thrombocytopenia with glucocorticoids, IVIG, or platelet transfusions depending on the clinical presentation. The most likely causative agent of this patient's thrombocytopenia-tirofiban-was discontinued, and the patient did not develop any signs of bleeding during the remainder of his hospital stay. His platelet count gradually improved to 24 G/L, and he was discharged on the sixth hospital day.
Total laparoscopic conservative surgery for an intramural ectopic pregnancy
Authors: Hiroshi Nabeshima, Mitsuo Nishimoto, Hiroki Utsunomiya, Maiko Arai, Tomohisa Ugajin, Yukihiro Terada, Nobuo Yaegashi
Journal: Diagn Ther Endosc (2010)
MeSH terms: Case Reports

A 38-year-old woman, gravida 3, para 1 with a history of a left salpingectomy for an ectopic pregnancy was admitted for treatment of a presumed ectopic pregnancy. Transvaginal sonography revealed an ill-defined gestational sac and fetal heart beat within the fundal myometrium adjacent to the left cornua. Laparoscopy was performed for a suspected left cornual pregnancy or intramural pregnancy. A cystic mass 3 cm in diameter was visible within the fundal myometrium. Total laparoscopic removal of the gestational sac was performed, and the uterus was preserved. Pathologic evaluation of the excised mass demonstrated chorionic villi involving the myometrium. In the literature, only one other case describing the laparoscopic removal of an intramural pregnancy has been reported. However, in the prior report, the patient still required hysterectomy after conservative surgery. Therefore, this is the first report of the successful treatment of an intramural pregnancy exclusively with laparoscopy.
Implementing the TRAPD model for the Saudi adaptation of the World Mental Health Composite International Diagnostic Interview 3.0
Authors: Mona Shahab, Feda Al-Tuwaijri, Noha Kattan, Lisa Bilal, Sanaa Hyder, Zeina Mneimneh, Yu-Chieh Lin, AbdulHameed Al-Habeeb, Abdullah Al-Subaie, Abdulrahman Binmuammar, Yasmin Altwaijri
Journal: Int J Ment Health Syst (2019)
Keywords: epidemiology, mental health, survey instrument, survey methodology, translation

Background:
The World Mental Health-Composite International Diagnostic Interview (CIDI) 3.0, originally in English, is a fully-structured interview designed for the assessment of mental disorders. Although Arabic translations of CIDI from countries like Lebanon and Iraq exist, a Modern Standard Arabic translation was developed to suit the Saudi population. While the translation model used in the present paper has been used to translate instruments in Asian and European languages, there is no study to the best of our knowledge which has used this specific model to translate a validated instrument from English to Arabic.
Case presentation:
This paper describes the Saudi adaptation of CIDI 3.0. The TRAPD team translation model-comprising of translation, review, adjudication, pretesting and documentation-was implemented to carry out the Saudi adaptation of CIDI 3.0. Pretests involving cognitive interviewing and pilot study led to translation revisions which consequently confirmed that Saudi respondents had a good understanding of various items of the instrument. The adaptation procedures for the Saudi CIDI 3.0 were well documented and the instrument was linguistically validated with the Saudi population.
Conclusion:
The TRAPD model was successfully implemented to adapt the CIDI 3.0 to be used as the main survey instrument for the Saudi National Mental Health Survey, findings of which will provide health policy makers mental health indicators for health decision making and planning.
Commissioning simulations to test new healthcare facilities: a proactive and innovative approach to healthcare system safety
Authors: Alyshah Kaba, Sue Barnes
Journal: Adv Simul (Lond) (2019)
Keywords: commissioning, healthcare systems, in situ, latent safety threats, new healthcare facilities, patient safety, process-orientated simulations, simulation, system integration, innovation

Development and reconstruction of new healthcare facilities and spaces has the potential for latent safety threats to emerge, specifically unintentional harm that could affect actual patients once the facility opens, such as missing equipment, inefficient setup, or insufficient space for procedures. Process-orientated simulation and testing is a novel innovation in healthcare. The aim of process-orientated simulations and debriefing is to examine the process of care, rather than the outcome of care. These simulations, which take place in actual patient care settings and environments prior to occupancy, are an emerging strategy that can be used to test new environments and new healthcare facilities to ensure that the spaces created match the needs of the staff and administration, while proactively identifying latent safety threats prior to delivering patient care. In turn, these simulations can be also be used as part of the new site orientation and training plan. The aim of this paper is to examine a case study describing the use of the novel innovation of process-orientated simulations to test the opening of a new 300-bed healthcare facility.
Transfusion associated peak in hb HPLC chromatogram - a case report
Authors: Sonal Jain, Jasmita Dass, Hara Prasad Pati
Journal: Mediterr J Hematol Infect Dis (2012)
MeSH terms: Case Reports

High performance liquid chromatography (HPLC) and electrophoresis are commonly used to diagnose various hemoglobinopathies. However, insufficient information about the transfusion history can lead to unexpected and confusing results. We are reporting a case of Juvenile myelomonocytic leukemia (JMML) in which HbHPLC was done to quantify fetal hemoglobin (HbF). The chromatogram showed elevated HbF along with a peak in the HbD window. A transfusion acquired peak was suspected based on the unexpectedly low percentage of HbD and was subsequently confirmed using parental HbHPLC.
Metastasis of Pregnancy-Associated Breast Cancer (Suspected to Be Hereditary Breast and Ovarian Cancer) to the Brain, Diagnosed at 18 Weeks' Gestation: A Case Report and Review of the Literature
Authors: Tomohiro Okuda, Sakura Yamamoto, Seiki Matsuo, Hisashi Kataoka, Jo Kitawaki
Journal: Case Rep Obstet Gynecol (2016)

We report a case of pregnancy-associated breast cancer with metastasis to the brain, likely resulting from hereditary breast and ovarian cancer (HBOC). A 35-year-old woman (gravida 2, para 0-1-0-1) underwent a right mastectomy and right axillary dissection after a cesarean section at 30 years of age; her mother died at 47 years of age due to breast cancer. Histopathological examination indicated an invasive ductal carcinoma with triple-negative cancer (cancer stage 2B [pT3N0M0]). The patient refused adjuvant therapy because of the risk of infertility. After 4 years, she became pregnant naturally. At 18 weeks' gestation, she experienced aphasia and dyslexia due to brain metastasis. The pregnancy was terminated at 21 weeks' gestation after thorough counseling. Her family history, young-onset disease, and histopathological findings suggested HBOC. She declined genetic testing for BRCA1/2, though genetic counseling was provided. In cases of pregnancy-related breast cancer, consideration must be given to whether the pregnancy should be continued and to posttreatment fertility. HBOC should also be considered. Genetic counseling should be provided and the patient should be checked for the BRCA mutation, as it is meaningful for the future of any potential children. Genetic counseling should be provided even if the cancer is advanced or recurrent.
Transforaminal Interbody Impaction of Bone Graft to Treat Collapsed Nonhealed Vertebral Fractures with Endplate Destruction: A Report of Two Cases
Authors: Adam M Wegner, Yu-Hsuan Chou, Hsiao-Kang Chang, Tsung-Cheng Yin
Journal: Case Rep Orthop (2020)
MeSH terms: Case Reports

Background:
A collapsed nonhealed vertebral fracture with endplate destruction is a challenging injury to address, as there is no single definitive treatment. We present two cases using an innovative transforaminal grafting technique to treat these patients. Case Presentation. Case 1: a 72-year-old woman had nonunion of an L1 compression fracture with destruction of both endplates. T12/L1 and L1/L2 transforaminal debridement and impaction of bone graft were performed followed by posterior instrumentation. At three years follow-up, the fusion mass between T12/L1 and L1/L2 was solid and the patient had minimal pain. Case 2: a 62-year-old woman had nonunion of an L1 burst fracture with destruction of the lower endplate. Hemilaminectomy and transforaminal interbody impaction of bone graft was performed. At three years follow-up, the patient had no back pain and a solid fusion. In both cases, local kyphosis was corrected and fusion obtained.
Conclusions:
Collapsed nonhealed vertebral body fractures combined with endplate destruction can be successfully treated with a one-step posterior surgery consisting of transforaminal debridement and impaction of bone graft in combination with posterior pedicle instrumentation.
Growth hormone deficiency, short stature, and juvenile rheumatoid arthritis in a patient with autoimmune polyglandular syndrome type 1: case report and brief review of the literature
Authors: Teresa Pun, Vikram Chandurkar
Journal: ISRN Endocrinol (2011)
MeSH terms: Case Reports

Autoimmune polyglandular syndromes (APSs) include a cluster of autoimmune and nonautoimmune conditions which have been classified into subtypes. APSs type 1 is characterized by at least two of the following: chronic mucocutaneous candidiasis, chronic hypoparathyroidism, and autoimmune Addison's disease (AD). We report the chronological history of a female patient who presented with features most consistent with APS type 1, along with growth hormone deficiency and juvenile rheumatoid arthritis (JRA). In terms of her autoimmune diagnoses, she first presented with JRA at three years of age, then hypocalcemia and hypoparathyroidism at five years of age, type 1 diabetes (DM 1) at age eleven years, adrenal insufficiency at age fourteen years, recurrent mucocutaneous candidiasis as a teenager, growth hormone deficiency at age fourteen years leading to significant short stature, primary amenorrhoea, and hypogonadism, and finally alopecia at age twenty-six years. In addition to this, she has suffered other nonautoimmune medical problems including a Tetralogy of Fallot with a surgical repair at age six years. On review of the medical literature, we found no other previously reported case with this unique combination of medical problems.
Complete Maxillary Crossbite Correction with a Rapid Palatal Expansion in Mixed Dentition Followed by a Corrective Orthodontic Treatment
Authors: Orlando Motohiro Tanaka, Isabelle Adad Fornazari, Ariane Ximenes Graciano Parra, Bruno Borges de Castilhos, Ademir Franco
Journal: Case Rep Dent (2016)

This case report presents the interceptive orthodontic treatment of a boy, aged 8 years 4 months with a Class I malocclusion with severe transverse maxillary deficiency and complete maxillary crossbite and correction using Haas expansion and fixed appliance. The treatment goals were to correct the posterior crossbite and anterior crossbite and restore the normality of the dentition and occlusion. In phase I, the patient was treated with a modified Haas-type palatal expander, which provided a clinically significant palatal expansion and increased the maxillary arch perimeter with favorable conditions for orthodontic treatment with fixed appliances in phase II. The optimization of E-space and the use of intermaxillary Class III elastics helped to maintain the mandibular incisors upright. A removable wraparound type appliance and a bonded lingual canine-to-canine retainer were used as retention. Although the literature has reported a high rate of relapse after palatal expansion, after 2 years 9 months of posttreatment follow-up, the occlusal result was stable and no skeletal reversals could be detected.
Familial recurrence of cerebral palsy with multiple risk factors
Authors: Lawrence P Richer, Nancy A Dower, Norma Leonard, Alicia K J Chan, Charlene M T Robertson
Journal: Case Rep Pediatr (2011)
MeSH terms: Case Reports

The recurrence of cerebral palsy in the same family is uncommon. We, however, report on two families with two or more affected siblings. In both families, numerous potential risk factors were identified including environmental, obstetric, and possible maternal effects. We hypothesize that multiple risk factors may lead to the increased risk of recurrence of cerebral palsy in families. Intrinsic and maternal risk factors should be investigated in all cases of cerebral palsy to properly counsel families on the risk of recurrence. Recent studies of genetic polymorphisms associated with cerebral palsy are considered with reference to our observations in these two families.