OpenMed/multicare-articles huggingface dataset:
Sirolimus combined with interferon-alpha 2b therapy for giant hepatic epithelioid hemangioendothelioma: a case report
Authors: Xiaolei Liu, Ruiquan Zhou, Shuang Si, Liguo Liu, Shiwei Yang, Dongdong Han, Haidong Tan
Journal: Front Oncol (2022)
Keywords: case report, epithelioid hemangioendothelioma, interferon, liver, sirolimus
MeSH terms: Case Reports

Hepatic epithelioid hemangioendothelioma (HEH) is a very rare tumor originated from vascular endothelial cells, with unpredictable malignancy. No standard treatment has been established yet. Although surgical resection and liver transplantation have been reported to be effective treatments with favorable long-term outcomes, the multiple intrahepatic lesions or extrahepatic metastasis makes these procedures unsuitable to most patients. Sirolimus was reported to be an effective drug for epithelioid hemangioendothelioma but only about 10% achieved partial response. Interferon-alpha 2b (IFN-a 2b) has also been used for the treatment of HEH, and the rate of tumor regression was more than 50%. Here, we report a HEH patient with giant intrahepatic tumor (>15cm), who achieved partial response after the combined therapy of sirolimus and IFN-a 2b. The giant intrahepatic lesion (>15 cm) regressed obviously after 8 months treatment and no severe adverse event was reported. The good response and safety of combined therapy with sirolimus and IFN-a 2b provide a promising guidance for future clinical study.
Giant post-inflammatory polyposis in a child with ulcerative colitis: A case report
Authors: Eva Karaskova, Maria Veghova-Velganova, Milos Geryk
Journal: Int J Surg Case Rep (2020)
Keywords: childhood, intestinal polyps, ulcerative colitis
MeSH terms: Case Reports

Introduction:
Post-inflammatory pseudopolyps (PIPs) develop in connection with an inflammatory process in the bowel. Masses larger than 15 mm are classified as giant PIPs. They are very rare, especially in children.
Presentation of case:
A case of 13-year-old girl suffering from ulcerative colitis (UC) and treated with corticosteroids and azathioprine is reported. Colonoscopic examination after achieving clinical remission revealed multiple giant PIPs. During endoscopic surveillance subsequent spontaneous regression of pseudopolyps was documented.
Discussion:
Patients with prolonged relapses of inflammatory bowel disease (IBD) are predisposed to PIPs. Giant PIPs may be related to post inflammatory mucosal regeneration or hyperplastic proliferation of the colonic mucosa between ulcerations after recurrent acute disease flares. Partial regression of giant polyps is uncommon, but has been reported. Some of these pseudopolyps are suitable for endoscopic polypectomy, but resection of PIPs is not generally advisable, because they usually regrow. Surgical intervention is advocated in symptomatic cases such as those with abdominal pain, severe hemorrhage or intestinal obstruction.
Conclusion:
The present case report of giant PIPs in an adolescent girl describes rare course of severe ulcerative colitis complicated by development of multiple giant PIPs. Due to asymptomatic course of the disease a conservative therapeutic approach was decided upon. Gradual regression of giant PIPs was observed during consecutive several year surveillance.
PAX3 gene deletion detected by microarray analysis in a girl with hearing loss
Authors: Malgorzata Drozniewska, Olga Haus
Journal: Mol Cytogenet (2014)
Keywords: array-cgh, craniofacial-deafness-hand syndrome, hearing loss, pax3 gene, waardenburg syndrome
MeSH terms: Case Reports

Deletions of the PAX3 gene have been rarely reported in the literature. Mutations of this gene are a common cause of Waardenburg syndrome type 1 and 3. We report a 16 year old female presenting hearing loss and normal intellectual development, without major features of Waardenburg syndrome type 1, and without family history of the syndrome. Her phenotype, however, overlaps with features of craniofacial-deafness-hand syndrome. Microarray analysis showed ~862 kb de novo deletion at 2q36.1 including PAX3. The above findings suggest that the rearrangement found in our patient appeared de novo and with high probability is a cause of her phenotype.
Don't Judge a Book by Its Cover: Factitious Disorder Imposed on Children-Report on 2 Cases
Authors: Noemi Faedda, Valentina Baglioni, Giulia Natalucci, Ignazio Ardizzone, Mauro Camuffo, Rita Cerutti, Vincenzo Guidetti
Journal: Front Pediatr (2018)
Keywords: child abuse, children, factitious disorder, münchausen syndrome by proxy, neglect, perpetrator, psychiatric disorder
MeSH terms: Case Reports

Factitious Disorder Imposed on Another (FDIA), also known as Munchausen Syndrome by Proxy (MSbP) is a very serious form of child abuse. The perpetrator, usually the mother, invents symptoms or causes real ones in order to make her child appear sick. Usually this is due to a maladaptive disorder or to an excessive of attention-seeking on her part. We report here two new cases of FDIA. The first one is a 9-year-old boy with a history of convulsive episodes, reduced verbal production, mild psychomotor disorder and urological problems who underwent several invasive procedures and hospitalizations before a diagnosis of FDIA was made. The second is a 12 year-old girl with headache, abdominal pain, lipothymic episodes, seizures and a gait impairment, who was hospitalized in several hospitals before an FDIA was diagnosed.
Brainstem Infarction and Panuveitis due to Sarcoidosis Successfully Treated with Steroid Pulse Therapy
Authors: Natsuyo Yoshida-Hata, Shigeko Yashiro, Noritoshi Arai, Sousuke Takeuchi
Journal: Case Rep Med (2012)
MeSH terms: Case Reports

A 36-year-old man visited our hospital because of blurred vision and redness of the conjunctiva. Slit-lamp examination showed panuveitis. Two days later, he suddenly experienced dizziness, speech disturbance, paralysis of his right extremities, and gait disturbances. Neurological examinations suggested that his symptoms were caused by a left lateral medullary lesion. He also had erythema mainly on his trunk. Magnetic resonance imaging (MRI) of his brain demonstrated a small infarct on the left side of the medulla oblongata. Clinical presentation and MRI findings were consistent with the diagnosis of a Wallenberg's syndrome. He also had bilateral hilar lymphadenopathy. A skin biopsy showed granulomatous nodular dermatitis compatible with sarcoidosis. He was treated with steroid pulse therapy and his neurological and ocular symptoms immediately improved. Only seven similar cases of intracranical sarcoidosis have been reported, but none had been treated with steroid pulse therapy. We recommend that steroid pulse therapy be considered to treat patients with sarcoidosis with signs of lesions in the central nervous system.
Oral Rehabilitation of a Pediatric Patient with Vitamin D-dependent Rickets II: A Rare Case Report
Authors: Anchal Chhonkar, Anil Gupta, Payal Chaudhary, Vani Kapoor
Journal: Int J Clin Pediatr Dent (2019)
Keywords: hypoplastic teeth, recurrent spontaneous abscess, vitamin d-dependent rickets
MeSH terms: Case Reports

Vitamin D-dependent rickets (VDDR) is a disorder of bone development characterized by softened weak bones. It is of two types-vitamin D-dependent rickets-I (VDDR-I) and vitamin D-dependent rickets type II (VDDR-II). Vitamin D-dependent rickets type II is a rare autosomal recessive disorder. The patients exhibit characteristic clinical features as well as numerous dental manifestations such as hypoplastic teeth, missing teeth, enlarged pulp chambers, and recurrent spontaneous abscesses. The case presented in this article is of vitamin D-dependent rickets type II in a pediatric dental patient who reported with multiple missing teeth and required treatment consisting of restorations and extractions. The aim of the present article is to raise awareness on the characteristics of this disorder, as well as its treatment and dental considerations.
How to cite this article:
Chhonkar A, Gupta A, et al. Oral Rehabilitation of a Pediatric Patient with Vitamin D-dependent Rickets II: A Rare Case Report. Int J Clin Pediatr Dent 2019;12(1):73-75.
A Rare Ectopic Ovary Mimicking Colon Sigmoideum Mesenchymoma Presenting as an Intestinal Mesenchymoma
Authors: Jiyong Pan, Shuang Wang, Hai Wang, Zhe Fan
Journal: Front Oncol (2019)
Keywords: gists, abdominal pain, colon sigmoideum mesenchymoma, ectopic ovary, intestinal mesenchymoma
MeSH terms: Case Reports

Ectopic ovaries are a rare occurrence. A 33-year-old woman presented to our unit for evaluation of a 2-year history of sporadic abdominal pain that was becoming sharp and frequent. Computed tomography (CT) suggested a gastrointestinal tract mesenchymoma. An abdominal laparotomy was performed and the tumor was excised for pathologic evaluation. A rapid frozen section pathologic examination showed a solitary fibrous tumor (SFT). The final pathology report was an ectopic ovary with corpora lutea bleeding. Ectopic ovaries are benign and the present case is the first report involving an ectopic ovary mimicking a gastrointestinal stromal tumor (GIST). The patient recovered well after surgery. Maldevelopment of the genital tract can lead to ectopic ovaries and surgery is a good management choice. The present case provides a possible differential diagnosis for GISTs.
Successful management of hamstring injuries in Australian Rules footballers: two case reports
Authors: Wayne T Hoskins, Henry P Pollard
Journal: Chiropr Osteopat (2005)

Hamstring injuries are the most prevalent injury in Australian Rules football. There is a lack of evidence based literature on the treatment, prevention and management of hamstring injuries, although it is agreed that the etiology is complicated and multi-factorial. We present two cases of hamstring injury that had full resolution after spinal manipulation and correction of lumbar-pelvic biomechanics. There was no recurrence through preventative treatment over a twelve and sixteen week period. The use of spinal manipulation for treatment or prevention of hamstring injury has not been documented in sports medicine literature and should be further investigated in prospective randomized controlled trials.
Neuroma of a double gallbladder: a case report
Authors: Valentina Lefemine, Taha R Lazim
Journal: Cases J (2009)

We report a case of 55 year old male patient who presented with recurrent upper abdominal pain following a laparoscopic cholecystectomy. A subsequent diagnostic laparoscopy revealed the presence of a second gallbladder which was initially missed. The peculiarity of his symptoms can in part be explained by the presence of a traumatic neuroma in his second gallbladder. A subsequent cholecystectomy led to a complete resolution of this patient's signs and symptoms. As far as we know this is the first report in the literature of a traumatic neuroma in a second gallbladder.
Case Report: Acute Renal Infarction in a Child With Coarctation of Aorta
Authors: Qing-Yun Zhang, Min-Hua Tseng, Jhao-Jhuang Ding, Jing-Long Huang
Journal: Front Pediatr (2021)
Keywords: coarcted aneurysm, glomerulonephritis, pediatrics, renal infarction, thrombus
MeSH terms: Case Reports

Renal arterial infarction can present with hematuria, proteinuria, and hypertension, features often linked to glomerular disease. An aortic aneurysm is an extraordinarily rare complication of coarctation of the aorta. Acute renal infarction caused by emboli from the aortic aneurysm is a possible complication that has not been reported. We herein report a 10-year-old boy who presented with hematuria, proteinuria, hypertension, and skin rashes on both lower extremities mimicking acute glomerulonephritis but actually resulting from acute renal infarction caused by a coarcted aneurysm-associated thrombus. He was successfully treated with surgical excision of the coarcted aorta and aneurysm followed by subcutaneous low molecular weight heparin without recurrence.
Micronodular Thymoma with Lymphoid Stroma: A Mediastinal Mass Masquerading as a Pericardial Mass
Authors: Kent Swimley, Hilda M Gonzalez-Bonilla, Alpana Senapati, Karla M Kurrelmeyer
Journal: Methodist Debakey Cardiovasc J (2021)
Keywords: lymphoid stroma, mediastinal mass, micronodular thymoma
MeSH terms: Thymoma / diagnostic imaging, Thymoma / surgery, Thymus Neoplasms / diagnostic imaging, Thymus Neoplasms / surgery, Case Reports, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Pericardium / diagnostic imaging, Tomography, X-Ray Computed

A 61-year-old man presented to the emergency room with lower extremity edema. Physical exam was only remarkable for a diastolic murmur in the right carotid area and left lower extremity edema. Venous Doppler revealed a deep venous thrombosis in the left lower extremity. Chest computed tomography (CT) with intravenous contrast ruled out pulmonary embolism but showed a mediastinal mass adjacent to the pericardium. Further imaging with cardiac magnetic resonance imaging (CMR) and cardiac CT angiography (CCTA) enabled localization and evaluation of the structural characteristics of the mass. The decision was made to excise the mass due to increasing size compared with its measurements on prior chest CTs and a high degree of vascularization seen on CMR and CCTA, which was concerning for an enlarging arteriovenous malformation or a hemangioma. However, histopathologic analysis of the mass revealed it to be a micronodular thymoma.
Clear-Cell Carcinoma of the Ovary with Bilateral Breast Metastases
Authors: Yehuda Galili, Meghan Lytle, Jonathan Bartolomei, Kataria Amandeep, Nichole Allen, S J Carlan, Mario Madruga
Journal: Case Rep Oncol Med (2019)
MeSH terms: Case Reports

Ovarian clear-cell carcinoma is an uncommon subtype of epithelial ovarian carcinoma. It carries a generally poor prognosis because of its resistance to standard treatment and metastatic spread to vital organs. Metastasis to the breast is rare and bilateral breast metastasis is unreported. A 61-year-old white female with a 5-year status poststandard therapy for stage IC clear-cell ovarian carcinoma presented with widespread metastasis. Tissue analysis revealed ovarian cancer metastasis to the breasts bilaterally. Clinical awareness of this metastatic potential is important when staging and developing a treatment plan for patients with ovarian clear-cell cancer.
Langerhans cell histiocytosis in the adult lumbar spine: case report
Authors: Bobby Wirawan Hassan, Bong Ju Moon, Young-Jin Kim, Sang-Deok Kim, Ki-Young Choi, Jung-Kil Lee
Journal: Springerplus (2016)
Keywords: adult spine, conservative method, langerhans cell histiocytosis, osteolytic lesion

Introduction:
Langerhans cell histiocytosis (LCH) occurs rarely in the spine of adults. The radiological findings usually resemble vertebral tumors. Etiology of LCH has not been clearly established yet. Therapeutic approaches are still controversial. We describe a case of LCH in an adult spine.
Case description:
A patient who presented with low back pain had an osteolytic lesion in the L1 vertebral body without neurological deficits, and fluoroscopy-guided needle biopsy of the L1 vertebral body was performed. The immunohistochemical diagnosis confirmed LCH. The patient was successfully treated with conservative methods.
Discussion:
The choice of appropriate therapy is very important, with treatment options varying from watch-and to aggressive treatment.
Conclusion:
LCH is considered as a pediatric disease that is extremely rare in the spine of adults and should be include in the differential diagnosis of osteolytic vertebral lesions. Conservative treatment is best choice for a patient with LCH without neurological deficit or spinal instability.
Haematological Malignancies in Systemic Sclerosis Patients: Case Reports and Review of the World Literature
Authors: M Colaci, D Giuggioli, C Vacchi, C Ferri
Journal: Case Rep Rheumatol (2017)
MeSH terms: Case Reports

Background. The association of systemic sclerosis (SSc) and haematological cancers was reported in a large number of case reports and cohort studies, describing SSc patients with highly heterogeneous clinical pictures. Objective. We reviewed the literature to better describe SSc patients with haematological malignancies. Methods. SSc cases complicated by haematological malignancies described in the world literature were collected; other 2 cases referred to our centre were reported. Results. One hundred-thirty SSc subjects were collected from 1954 up to date. The mean age of patients at cancer diagnosis was 56.1 ± 16.7 years; 72% of patients were females. In 60% of cases, the diagnosis of haematological malignancy was described within 5 years of SSc diagnosis. In 7.8% of cases, coexistence of Sjögren's syndrome or other autoimmune disorders was cited. Sixty-six cases with lymphoma (in the majority of cases B-cell neoplasms), 28 with leukaemia (chronic lymphocytic form in 9), 14 with multiple myeloma plus one solitary IgM plasmocytoma, and 16 with myeloproliferative disorders were found. No specific SSc subsets seem to be related to haematological malignancies. Conclusions. We remarked the importance of clinical work-up in SSc, in order to early diagnose and treat eventual occult haematological malignancies, especially during the first years of the disease.
Plasmapheresis reverses all side-effects of a cisplatin overdose--a case report and treatment recommendation
Authors: Guenter Hofmann, Thomas Bauernhofer, Peter Krippl, Doris Lang-Loidolt, Sabine Horn, Walter Goessler, Walter Schippinger, Ferdinand Ploner, Herbert Stoeger, Hellmut Samonigg
Journal: BMC Cancer (2006)
MeSH terms: Antineoplastic Agents / toxicity, Cisplatin / toxicity, Plasmapheresis / methods, Case Reports, Antineoplastic Agents / blood, Carcinoma, Non-Small-Cell Lung / drug therapy, Cisplatin / blood, Female, Hearing Loss / chemically induced, Humans, Liver / enzymology, Lung Neoplasms / drug therapy, Middle Aged, Nausea / chemically induced, Renal Insufficiency / chemically induced, Time Factors, Vomiting / chemically induced, Antineoplastic Agents, Cisplatin

Background:
Cisplatin is widely used as an antineoplastic agent since it is effective against a broad spectrum of different tumours. Nevertheless, it has several potential side effects affecting different organ systems and an overdose may lead to life-threatening complications and even death.
Case presentation:
We report on a 46-year old woman with non-small cell lung cancer who accidentally received 225 mg/m2 of cisplatin, which was threefold the dose as scheduled, within a 3-day period. Two days later, the patient presented with hearing loss, severe nausea and vomiting, acute renal failure as well as elevated liver enzymes. In addition, she developed a severe myelodepression. After plasmapheresis on two consecutive days and vigorous supportive treatment, the toxicity-related symptoms improved and the patient recovered without any sequelae.
Conclusion:
To date, no general accepted guidelines for the treatment of cisplatin overdoses are available. Along with the experience from other published cases, our report shows that plasmapheresis is capable of lowering cisplatin plasma and serum levels efficiently. Therefore, plasma exchange performed as soon as possible can ameliorate all side effects of a cisplatin overdose and be a potential tool for clinicians for treatment. However, additional intensive supportive treatment-modalities are necessary to control all occurring side effects.
Massive suprachoroidal hemorrhage: Surgical management and outcome
Authors: Thomas Laube, Claudia Brockmann, Norbert Bornfeld
Journal: GMS Ophthalmol Cases (2015)
Keywords: cataract extraction, massive suprachoroidal hemorrhage, silicone oil, vitrectomy
MeSH terms: Case Reports

Objective:
To describe options for vitreoretinal surgery in the management of massive suprachoroidal hemorrhage (SCH).
Methods:
Visual acuity (VA), ocular findings, timing of surgical intervention, surgical procedures, and outcomes of four patients diagnosed with massive SCH and admitted to the University Eye Clinic Essen were reviewed retrospectively.
Results:
Four eyes of four patients (mean age, 82 years; range, 74-89 years) were studied. In three cases the occurrence of SCH was related to cataract surgery and occurred intra- or postoperatively. One patient developed spontaneous SCH of unclear origin. Three patients had a history of arterial hypertension; one eye had high myopia, two patients suffered from cardiovascular diseases, and two patients had glaucoma. Postoperative follow up of the patients ranged from 5 to 29.5 months (mean, 19.6 months). Transscleral drainage of SCH was in all cases combined with pars plana vitrectomy, use of heavy liquids (perfluorodecalin) and silicone oil tamponade. The mean time interval from hemorrhage to surgical intervention was 16.5 days (range 5-29 days). Preoperative VA of all eyes was light perception. Two patients achieved a final postoperative visual acuity of 20/20 and 20/320, respectively, one patient improved to hand motion, and one patient resulted in no light perception.
Conclusions:
Surgical interventions including transscleral drainage of SCH, vitrectomy, and silicone oil tamponade are valuable options in the management of massive SCH to save the eye and possibly improve the otherwise extreme poor prognosis.
Fusarium Endophthalmitis following Cataract Surgery: Successful Treatment with Intravitreal and Systemic Voriconazole
Authors: Paulo A Alves da Costa Pertuiset, Juan F Batlle Logroño
Journal: Case Rep Ophthalmol Med (2016)

Purpose. To report a case of postoperative endophthalmitis caused by Fusarium species successfully treated with intravitreal and systemic voriconazole after treatment failure with amphotericin B. Methods. Clinical case report of a 60-year-old immunocompetent woman who presents with endophthalmitis of unknown origin 4 weeks after uneventful cataract extraction and IOL implantation surgery. IOL explantation, vitrectomy with capsular bag removal, vitreous aspiration for culture, and intravitreal injection of amphotericin B (5 μg/0.1 mL) were performed. Diagnosis was established by culturing the vitreous aspirate on a Sabouraud agar medium and staining with lactophenol blue solution. Five days later, there was no clinical response. The decision was made to administer a single dose of intravitreal voriconazole (2.5 μg/0.1 mL) and oral voriconazole (200 mg BID) for 30 days. Results. Fusarium sp. grew on culture. Treatment with local and systemic voriconazole was started after no improvement with vitrectomy, IOL explantation, and intravitreal amphotericin B. After 1 month of treatment, the infection resolved and best-corrected visual acuity was 20/25. Conclusion. In patients with endophthalmitis caused by Fusarium sp., topical and systemic voriconazole treatment should be considered in cases resistant to intravitreal amphotericin B.