OpenMed/multicare-articles huggingface dataset:
Cluster-Like Headache Secondary to Anamnesis of Sphenoid Ridge Meningioma: A Case Report and Literature Review
Authors: Liang Kou, Jinsha Huang, Yan Xu, Chao Han, Kai Ma, Xingfang Guo, Yun Xia, Fang Wan, Sijia Yin, Junjie Hu, Jiawei Wu, Yadi Sun, Guoxin Zhang, Ling Liu, Nian Xiong, Tao Wang
Journal: Front Neurol (2019)
Keywords: cluster headache, craniotomy, glial hyperplasia, meningioma, postoperative headache, symptomatic
MeSH terms: Case Reports

Cluster headache is generally considered to be a primary headache; secondary cluster-like headache is quite rare, while cluster-like headache secondary to meningioma is even rarer. Here, we describe an unusual case with cluster-like headache 2.5 years after sphenoid ridge meningioma surgery. The cluster-like headache and meningioma were on the same side, and even at the same position. Furthermore, the cluster-like headache lasted for 6 months. In addition, the patient did not respond well to conventional treatments for cluster headache, such as oxygen inhalation, carbamazepine, and tramadol. Brain magnetic resonance imaging demonstrated a softening lesion, glial hyperplasia, and localized thickening and enhancement of the dura in the left frontal-temporal lobe. However, positron-emission computed tomography showed reduced metabolism in the left frontal-temporal lobe. Although the possibility of a primary headache cannot be completely eliminated, the association between cluster-like headache and probable tumor recurrence or postoperative changes should be considered.
Case report: The promising application of dynamic functional connectivity analysis on an individual with failed back surgery syndrome
Authors: Jingya Miao, Isaiah Ailes, Laura Krisa, Kristen Fleming, Devon Middleton, Kiran Talekar, Peter Natale, Feroze B Mohamed, Kevin Hines, Caio M Matias, Mahdi Alizadeh
Journal: Front Neurosci (2022)
Keywords: case report, dynamic functional connectivity, failed back surgery syndrome, resting state fmri, spinal cord stimulation
MeSH terms: Case Reports

Failed back surgery syndrome (FBSS), a chronic neuropathic pain condition, is a common indication for spinal cord stimulation (SCS). However, the mechanisms of SCS, especially its effects on supraspinal/brain functional connectivity, are still not fully understood. Resting state functional magnetic resonance imaging (rsfMRI) studies have shown characteristics in patients with chronic low back pain (cLBP). In this case study, we performed rsfMRI scanning (3.0 T) on an FBSS patient, who presented with chronic low back and leg pain following her previous lumbar microdiscectomy and had undergone permanent SCS. Appropriate MRI safety measures were undertaken to scan this subject. Seed-based functional connectivity (FC) was performed on the rsfMRI data acquired from the FBSS subject, and then compared to a group of 17 healthy controls. Seeds were identified by an atlas of resting state networks (RSNs), which is composed of 32 regions grouped into 8 networks. Sliding-window method and k-means clustering were used in dynamic FC analysis, which resulted in 4 brain states for each group. Our results demonstrated the safety and feasibility of 3T MRI scanning in a patient with implanted SCS system. Compared to the brain states of healthy controls, the FBSS subject presented very different FC patterns in less frequent brain states. The mean dwell time of brain states showed distinct distributions: the FBSS subject seemed to prefer a single state over the others. Although future studies with large sample sizes are needed to make statistical conclusions, our findings demonstrated the promising application of dynamic FC to provide more granularity with FC changes associated with different brain states in chronic pain.
Molecular diagnosis of analbuminemia: a new case caused by a nonsense mutation in the albumin gene
Authors: Monica Dagnino, Gianluca Caridi, Ueli Haenni, Adrian Duss, Fabienne Aregger, Monica Campagnoli, Monica Galliano, Lorenzo Minchiotti
Journal: Int J Mol Sci (2011)
Keywords: dna sequence, analbuminemia, heteroduplex analysis, human serum albumin, single-strand conformation polymorphism
MeSH terms: Codon, Nonsense, Pathology, Molecular / methods, Serum Albumin / deficiency, Serum Albumin / genetics, Case Reports, Research Support, Non-U.S. Gov't, Asian People / genetics, Exons, Heteroduplex Analysis, Humans, Male, Middle Aged, Polymorphism, Single-Stranded Conformational, Sequence Analysis, DNA, Switzerland, Codon, Nonsense, Serum Albumin

Analbuminemia is a rare autosomal recessive disorder manifested by the absence, or severe reduction, of circulating serum albumin (ALB). We report here a new case diagnosed in a 45 years old man of Southwestern Asian origin, living in Switzerland, on the basis of his low ALB concentration (0.9 g/L) in the absence of renal or gastrointestinal protein loss, or liver dysfunction. The clinical diagnosis was confirmed by a mutational analysis of the albumin (ALB) gene, carried out by single-strand conformational polymorphism (SSCP), heteroduplex analysis (HA), and DNA sequencing. This screening of the ALB gene revealed that the proband is homozygous for two mutations: the insertion of a T in a stretch of eight Ts spanning positions c.1289 + 23-c.1289 + 30 of intron 10 and a c.802 G > T transversion in exon 7. Whereas the presence of an additional T in the poly-T tract has no direct deleterious effect, the latter nonsense mutation changes the codon GAA for Glu244 to the stop codon TAA, resulting in a premature termination of the polypeptide chain. The putative protein product would have a length of only 243 amino acid residues instead of the normal 585 found in the mature serum albumin, but no evidence for the presence in serum of such a truncated polypeptide chain could be obtained by two dimensional electrophoresis and western blotting analysis.
Case Report: Hepatic Adenoma in a Child With a Congenital Extrahepatic Portosystemic Shunt
Authors: Hannah Glonnegger, Maren Schulze, Simone Kathemann, Sebastian Berg, Hannah Füllgraf, Andrea Tannapfel, Patrick Gerner, Jochen Grohmann, Charlotte Niemeyer, Simone Hettmer
Journal: Front Pediatr (2020)
Keywords: abernethy malformation, ceps, child, congenital extrahepatic portosystemic shunt, hepatic adenoma
MeSH terms: Case Reports

Congenital extrahepatic portosystemic shunts (CEPS), previously also described as Abernethy malformations, are rare malformations in which the extrahepatic portal system directly communicates with the vena cava inferior, thereby bypassing the liver. A hypoplastic portal vein (PV) exists in most cases. CEPS have been associated with the development of liver nodules, ranging from mostly focal nodular hyperplasia (FNH) to hepatic adenoma (HA) and even hepatocellular carcinoma (HCC). Tumor development in CEPS may be due to changes in perfusion pressures, oxygen supply or endocrine imbalances. It is important to rule out CEPS in children with liver tumors, because resection could impede future shunt occlusion procedures, and benign masses may regress after shunt occlusion. Here, we review the case of a 9-years-old male with CEPS and hepatic nuclear Factor 1-alpha (HNF-1-alpha) inactivated HA to raise awareness of this condition and review histopathological changes in the liver of CEPS.
Combined use of clips and nylon snare ("tulip-bundle") as a rescue endoscopic bleeding control in a mallory-weiss syndrome
Authors: Hrvoje Ivekovic, Bojana Radulovic, Suzana Jankovic, Pave Markos, Nadan Rustemovic
Journal: Case Rep Gastrointest Med (2014)

Mallory-Weiss syndrome (MWS) accounts for 6-14% of all cases of upper gastrointestinal bleeding. Prognosis of patients with MWS is generally good, with a benign course and rare recurrence of bleeding. However, no strict recommendations exist in regard to the mode of action after a failure of primary endoscopic hemostasis. We report a case of an 83-year-old male with MWS and rebleeding after the initial endoscopic treatment with epinephrine and clips. The final endoscopic control of bleeding was achieved by a combined application of clips and a nylon snare in a "tulip-bundle" fashion. The patient had an uneventful postprocedural clinical course and was discharged from the hospital five days later. To the best of our knowledge, this is the first case report showing the "tulip-bundle" technique as a rescue endoscopic bleeding control in the esophagus.
Vulnerability and agency in research participants' daily lives and the research encounter: A qualitative case study of participants taking part in scrub typhus research in northern Thailand
Authors: Rachel C Greer, Nipaphan Kanthawang, Jennifer Roest, Tri Wangrangsimakul, Michael Parker, Maureen Kelley, Phaik Yeong Cheah
Journal: PLoS One (2023)
MeSH terms: Ethnicity, Scrub Typhus, Research Support, Non-U.S. Gov't, Humans, Minority Groups, Qualitative Research, Thailand

Background:
Researchers have a responsibility to protect all participants, especially vulnerable participants, from harm. Vulnerability is increasingly understood to be context specific, yet limited guidance is available regarding the vulnerability and agency of research participants in different cultural settings. This study aims to explore research participants' daily vulnerability and agency, and how these interact with participants' research experiences in their own words. Researchers' views and responses were also explored.
Methods:
A qualitative study was conducted around two scrub typhus research studies in northern Thailand. A thematic analysis was carried out on 42 semi-structured interviews with research participants, their families, researchers and key informants.
Results:
The majority of the research participants belonged to a hill tribe ethnic minority group. Common challenges were related to Thai language barriers, travel difficulties, uncertain legal status, unstable employment, lack of education and healthcare. We did not identify new vulnerabilities but we found that the extent of these vulnerabilities might be underestimated or even hidden from researchers in some cases. Despite these challenges people demonstrated agency in their daily lives and were often motivated and supported in this by family members. The majority of perceived research benefits were related to healthcare and gaining knowledge, while attending follow-up visits could be a burden for some.
Conclusions:
Our approach to research in culturally and socioeconomically diverse settings should be more responsive to participants' specific vulnerabilities and abilities evidenced in their daily life, rather than attributing vulnerability on the basis of membership of pre-defined 'vulnerable groups'. Researchers need to be aware and responsive towards the challenges participants face locally in order to minimise the burdens of research participation whilst allowing participants to benefit from research.
Case Report: Brentuximab Vedotin Associated Acute Pancreatitis in a Pediatric Hodgkin Lymphoma Patient: Case Report and Literature Review
Authors: Ewelina Truszkowska, Marta Andrzejewska, Cyntia Szymańska, Agnieszka Wziątek, Katarzyna Derwich
Journal: Pathol Oncol Res (2022)
Keywords: hodgkin lymphoma, acute pancreatitis, brentuximab vedotin, pediatric oncology, side effects
MeSH terms: Hodgkin Disease, Immunoconjugates, Lymphoma, Large-Cell, Anaplastic, Pancreatitis, Case Reports, Review, Acute Disease, Adolescent, Brentuximab Vedotin, Child, Humans, Male, Pain, Immunoconjugates, Brentuximab Vedotin

Brentuximab vedotin is a conjugate drug used mainly in Hodgkin lymphoma, systemic and primary cutaneous anaplastic large cell lymphomas, and CD30-expressing peripheral T-cell lymphoma. We report a unique case of acute pancreatitis associated with brentuximab vedotin in a 17-year-old male patient suffering from classical Hodgkin lymphoma. Diagnosed in 2020, the patient was classified to an intermediate therapeutic group and disease's grade was IIIAE. The patient was treated with brentuximab vedotin and bendamustine in the third line. Two weeks after the drug administration, the patient developed acute epigastric pain. Laboratory and radiological findings confirmed the clinical suspicion of acute pancreatitis that was managed with opioid pain medications, meropenem, parenteral nutrition, ondansetron and omeprazole. This is the first case report of brentuximab vedotin-associated acute pancreatitis in the pediatric patient reported in the literature to the best of our knowledge.
Removal of a Horizontally Displaced Dental Implant below the Mandibular Canal
Authors: Khodor Ahmed Fakih, Maria Stiliyanova Edreva, Biser Borisov Stoichkov
Journal: Case Rep Dent (2023)
MeSH terms: Case Reports

A clinical case of a horizontally displaced dental implant, which moved below the level of the mandibular canal during surgery is presented together with a brief review of the comparable published cases. The bone mineral density and the morphology of the alveolar ridge were analyzed at the site of osteotomy, and the low bone density of 265.32 ± 86.41 Hounsfield Units was found in the area. The factors related to implant displacement were: the anatomical features of bone structure, and the applied mechanical pressure during the implant insertion. The displacement of the dental implant below the level of the mandibular canal during implantation can be a severe complication. Its removal requires the safest surgical approach to avoid damaging the inferior alveolar nerve. The description of one clinical case does not provide grounds for drawing definite conclusions. To avoid similar incidents, detailed radiographic assessment before implantation is necessary; it is also important to follow the surgical protocols of implant placement into soft bone and to create conditions for a good visibility and sufficient control of bleeding during surgery.
Extramedullary Solitary Plasmacytoma with Anaplastic Features of the Nasopharynx
Authors: Parikshit Padhi, Radwa El-Behery
Journal: Case Rep Hematol (2020)
MeSH terms: Case Reports

Extramedullary plasmacytomas (ESPs) are rare forms of plasma cell dyscrasias and usually are seen in the upper aerodigestive tract. ESPs with anaplastic features are extremely rare, and no treatment guidelines exist. We present a 75-year-old gentleman presented with left nasal blockage, and on examination, a polypoid left nasal mass was seen. He was, then, referred to ENT after a CT scan revealed a mass in the left nasopharynx for a biopsy. The preliminary reports suggested a high-grade lymphoma; however, after further testing, it was revealed to be an anaplastic plasma cell neoplasm. PET scan, bone marrow biopsy, serum and urine protein electropheresis, serum immunofixation and light chains were all unremarkable for systemic disease. Differential diagnosis included plasmablastic lymphoma, NK/T cell lymphoma-nasal type, and squamous cell cancers of the head and neck. He was treated with radiation alone given his comorbidities. Given there are no treatment guidelines, we would like to highlight this rare case and discuss different potential management options such as radiation, chemotherapy, surgery, or a combination of different modalities.
Orthographic Visualisation Induced Brain Activations in a Chronic Poststroke Global Aphasia with Dissociation between Oral and Written Expression
Authors: Jurgita Usinskiene, Michael Mouthon, Chrisovalandou Martins Gaytanidis, Agnes Toscanelli, Jean-Marie Annoni
Journal: Case Rep Neurol Med (2019)
MeSH terms: Case Reports

We propose a method of orthographic visualisation strategy in a poststroke severe aphasia person with dissociation between oral and written expression. fMRI results suggest that such strategy may induce the engagement of alternative nonlanguage networks and visual representations may help improving oral output. This choice of rehabilitation method can be based on the remaining capacities and, therefore, on written language. Most notably, no study so far addressed how orthographic visualisation strategy during speech rehabilitation might influence clinical outcomes in nonfluent aphasia and apraxia patients.
Psychogenic Foreign Accent Syndrome: A New Case
Authors: Stefanie Keulen, Jo Verhoeven, Louis De Page, Roel Jonkers, Roelien Bastiaanse, Peter Mariën
Journal: Front Hum Neurosci (2016)
Keywords: accent attribution experiment, accent rating experiment, foreign accent syndrome, psychodiagnostics, psychogenic fas, speech disorder
MeSH terms: Case Reports

This paper presents the case of a 33-year-old, right-handed, French-speaking Belgian lady who was involved in a car accident as a pedestrian. Six months after the incident she developed a German/Flemish-like accent. The patient's medical history, the onset of the FAS and the possible psychological causes of the accent change are analyzed. Relevant neuropsychological, neurolinguistic, and psychodiagnostic test results are presented and discussed. The psychodiagnostic interview and testing will receive special attention, because these have been underreported in previous FAS case reports. Furthermore, an accent rating experiment was carried out in order to assess the foreign quality of the patient's speech. Pre- and post-morbid spontaneous speech samples were analyzed phonetically to identify the pronunciation characteristics associated with this type of FAS. Several findings were considered essential in the diagnosis of psychogenic FAS: the psychological assessments as well as the clinical interview confirmed the presence of psychological problems, while neurological damage was excluded by means of repeated neuroimaging and neurological examinations. The type and nature of the speech symptoms and the accent fluctuations associated with the patient's psychological state cannot be explained by a neurological disorder. Moreover, the indifference of the patient toward her condition may also suggest a psychogenic etiology, as the opposite is usually observed in neurogenic FAS patients.
Vitamin B12 Deficiency as a Cause of Neurotrophic Keratopathy
Authors: Nader Nassiri, Farhad Assarzadegan, Mansoor Shahriari, Hamid Norouzi, Sara Kavousnezhad, Nariman Nassiri, Kourosh Sheibani
Journal: Open Ophthalmol J (2018)
Keywords: corneal sensation, deficiency, keratopathy, neurotrophic, vitamin, vitamin b12
MeSH terms: Case Reports

Introduction:
Neurotrophic keratitis is a rare degenerative corneal disease caused by an impairment of trigeminal corneal innervation, leading to a decrease or absence of corneal sensation. Here, we present a case of neurotrophic keratopathy caused by B12 deficiency in a 34 years old man who had a progressive decrease in visual acuity and corneal involvement since 3 months before being referred to our ophthalmology clinic.
Result and discussion:
Based on our clinical findings and with the diagnosis of B12 deficiency we started B12 treatment for the patient. After 3 weeks the patient showed a dramatic response with corneal sensation reversal, an increase of visual acuity, improved neurotrophic keratopathy and significantly improved neurological findings. To the best of our knowledge, there is no report regarding vitamin B12 deficiency induced keratopathy and this is the first report that describes this aspect of vitamin B12 deficiency.
Right Upper Lobe Torsion after Right Lower Lobectomy: A Rare and Potentially Life-Threatening Complication
Authors: Takeo Nakada, Yo Tsukamoto, Mitsuo Yabe, Takeyuki Misawa, Tadashi Akiba, Takashi Ohtsuka
Journal: Case Rep Pulmonol (2018)
MeSH terms: Case Reports

An 84-year-old woman was referred to our institution with suspected right lung cancer. Subsequently, she underwent thoracoscopic right lower lobectomy without mediastinal lymph node dissection. Postoperatively, she complained of dyspnea and developed arterial oxygen desaturation after 12 h and acute respiratory failure (ARF). An emergency chest computed tomography revealed the right upper bronchial stenosis with hilar peribronchovascular soft tissue edema because the middle lung lobe had been pushed upward and forward and the right upper lung lobe had twisted dorsally. Emergency bronchoscopy revealed severe right upper bronchial stenosis with an eccentric rotation and severe edema. The bronchia stenosis was successfully treated with glucocorticoids and noninvasive positive pressure ventilation for ARF.
Ribavirin Treatment for Severe Schizophrenia with Anti-Borna Disease Virus 1 Antibodies 30 Years after Onset
Authors: Hidenori Matsunaga, Akio Fukumori, Kohji Mori, Takashi Morihara, Shunsuke Sato, Kyoko Kitauchi, Kanta Yanagida, Kazumi Taguchi, Tomoyuki Honda, Keizo Tomonaga
Journal: Case Rep Psychiatry (2023)
MeSH terms: Case Reports

Objective:
Borna disease virus 1 (BoDV-1) was proven to cause fatal encephalitis in humans in 2018. However, the effects of persistent infections remain unclear. Here, we present the case of a 50-year-old woman with a 30-year history of severe schizophrenia, who was exposed to fleas from stray cats prior to disease onset, suggesting the possibility of zoonosis including BoDV-1 infection. The patient had experienced significant social impairment, thought deterioration, delusions, and hallucinations for more than 20 years.
Method:
A radioligand assay was used to test the patient for IgG and IgM antibodies against BoDV-1 nucleoprotein (N) and phosphoprotein (P). Based on the protocol for hepatitis C, we treated the patient with 400 mg/day ribavirin, which was later increased to 600 mg/day.
Results:
The serological examination revealed anti-BoDV-1 N IgG. Although only subtle changes were observed over the 24 weeks of treatment, the family noticed that the patient's Cotard delusions had disappeared 7 months after completing the treatment, accompanied by some improvements in the relationship with the family.
Conclusion:
Though definite proof was not obtained, this presumed suppression of BoDV-1 by ribavirin leading to improvements in Cotard syndrome-like symptoms suggests that intractable schizophrenia might be one of the BoDV-1 infection phenotypes. Further studies are needed to clarify the effect of persistent BoDV-1 infections in humans.
Bilateral Sertoli Cell Tumors in a Patient with Androgen Insensitivity Syndrome
Authors: Roberta Fonseca de Souza, Janaina Pereira da Silva, Bruno Vieira Balla, Rodrigo Neves Ferreira, Antônio Chambô Filho
Journal: Case Rep Obstet Gynecol (2017)
MeSH terms: Case Reports

Androgen insensitivity syndrome is the most common cause of male pseudohermaphroditism and the third most common cause of primary amenorrhea. This genetic alteration is a consequence of inherited defects on the X chromosome causing total or partial damage to the intrauterine virilization process due to functional abnormalities in the androgen receptors. The present report describes a 22-year-old patient with a female phenotype and a 46, XY karyotype, presenting with bilateral inguinal tumors. The tumors were surgically removed at the Santa Casa de Misericórdia Hospital in Vitória, Espírito Santo, Brazil. Pathology revealed bilateral testicles with Sertoli cell tumors. According to the international literature, prophylactic gonadectomy following puberty is recommended due to the progressive risk of neoplastic transformation in the residual gonads.