OpenMed/multicare-articles huggingface dataset:
An unusual etiology of posttraumatic Collet-Sicard Syndrome: a case report
Authors: Walid Mnari, Mohamed Kilani, Khaled Harrathi, Mezri Maatouk, Jamel Koubaa, Mondher Golli
Journal: Pan Afr Med J (2016)
Keywords: ct scan, cranial nerve palsy, fracture, styloid process
MeSH terms: Cranial Nerve Diseases / etiology, Head Injuries, Closed / complications, Skull Fractures / complications, Case Reports, Cranial Nerve Diseases / diagnostic imaging, Follow-Up Studies, Humans, Magnetic Resonance Imaging / methods, Male, Skull Fractures / diagnostic imaging, Skull Fractures / etiology, Tomography, X-Ray Computed / methods, Young Adult

Posttraumatic Unilateral paralysis of the last four cranial nerves (IX-XI), known as collet-Sicard syndrome, is rare following closed head injury. A 21-year-old man presented with slurred speech, hoarseness voice and difficulty swallowing his saliva following closed head trauma. The cranial nerve examination revealed left sided severe dysfunction of cranial nerves VII, IX, X, XI, and XII. A CT-Scan of the neck was performed demonstrating a fracture of the left styloid process at the base of the skull. The Magnetic Resonance Imaging showed unusually well seen lower cranial nerves due to nerve edema. The patient was managed conservatively with steroids and regular sessions of neuromuscular and orthophonic rehabilitation. The nutrition had to be administered by gastrostomy since he was unable to swallow. Six months after the injury a total neurological recovery was noted. We present the exceptional case of Collet-Sicard Syndrome caused by styloid process fracture.
Writer's cramp as a presentation of L-2-hydroxyglutaric aciduria
Authors: Pichet Termsarasab, Steven J Frucht
Journal: J Clin Mov Disord (2014)
Keywords: dystonia, l-2-hydroxyglutaric aciduria, metabolic disease, movement disorders, writer’s cramp
MeSH terms: Case Reports

L-2-hydroxyglutaric aciduria (L2HGA) is a neurometabolic disorder characterized by macrocephaly, seizures, progressive mental retardation, pyramidal signs, ataxia and tremor. Dystonia is an under-recognized feature of this entity in the literature. We report two siblings with L2HGA, one of whom presented with writer's cramp followed by dystonia of the other hand. An elevated plasma lysine, highly elevated urine 2-hydroxyglutaric acid, and MRI with characteristic findings (leukoencephalopathy of bilateral subcortical white matter sparing central white matter) suggested the diagnosis, which was confirmed by genetic testing.
Case report: Basivertebral nerve block during vertebral augmentation: an alternative approach to intraprocedural pain management
Authors: Giovanni C Santoro, Siddhant Kulkarni, Diljot Dhillon, Kenny Lien
Journal: Front Radiol (2023)
Keywords: anesthesia, kyphoplasty, nerve block, pain, vertebral augmentation, vertebroplasty
MeSH terms: Case Reports

Osteoporotic compression fractures can be treated with vertebral augmentation. Since intraprocedural pain is common during vertebral body endplate manipulation, these procedures are often performed with conscious sedation or general anesthesia. Research has shown that vertebral endplates are innervated by the basivertebral nerve (BVN), which has been successfully targeted via radiofrequency ablation to treat chronic vertebrogenic lower back pain. With this physiology in mind, we evaluated if temporary BVN block would provide sufficient analgesia so that patients could forego sedation during percutaneous vertebral augmentation. Ten patients with single-level vertebral compression fractures were selected. Prior to balloon augmentation, temporary intraosseous BVN block was achieved using 2% lidocaine injection. All ten patients successfully completed their procedure without intraprocedural sedative or narcotic medications, and without significant deviation from baseline vital signs. Temporary BVN block can be used as intraprocedural anesthesia in select patients who may be poor candidates for general anesthesia or conscious sedation.
The Implications of Liver Biopsy Results in Patients with Myeloproliferative Neoplasms Being Treated with Ruxolitinib
Authors: Douglas Tremblay, Juan Putra, Alexander Vogel, Adam Winters, Ronald Hoffman, Thomas D Schiano, Maria Isabel Fiel, John O Mascarenhas
Journal: Case Rep Hematol (2019)
MeSH terms: Case Reports

Ruxolitinib is increasingly being utilized for the treatment of myelofibrosis and polycythemia vera, but the potential for hepatic toxicity is poorly understood. We performed a retrospective review of hepatic damage occurring in patients with myeloproliferative neoplasms receiving ruxolitinib. Relevant histologic images of liver biopsies were reviewed by an experienced liver pathologist and reported to a multidisciplinary team including hepatology and hematology. A variety of liver pathology was observed including extramedullary hematopoiesis, obliterative portal venopathy, and drug-induced liver injury. In all cases reviewed, the liver biopsy had significant treatment implications. We conclude that hepatology referral and liver biopsy in patients receiving ruxolitinib therapy with biochemical evidence of liver injury reveals a variety of etiologies which have significant treatment impact. Clinicians should be aware of the potential causes of liver damage in this population and initiate prompt referral and liver biopsy.
A case report of breast cancer in silicone-injected breasts diagnosed by an emerging technique of contrast-enhanced mammography-guided biopsy
Authors: Yun-Chung Cheung, Wen-Lin Kuo, Li-Yu Lee, Ya-Chun Tang
Journal: Front Oncol (2022)
Keywords: breast biopsy, breast cancer, contrast-enhanced mammography-guided biopsy, contrast-enhanced spectral mammography, silicone-injected breast
MeSH terms: Case Reports

Background:
Breast cancer in silicone-injected breasts is often obscured in conventional mammography and sonography. Contrast-enhanced magnetic resonance imaging (CE-MRI) is an optimal modality for cancer detection. This case report demonstrates the use of contrast-enhanced spectral mammography (CESM) and CESM-guided biopsy (CESM-Bx) to diagnose breast cancer in silicone-injected breasts. However, there is no relevant report in the literature.
Case presentation:
A 59-year-old woman who received a liquid silicone injection for breast augmentation 30 years ago was transferred to our hospital for a CE-MRI-guided biopsy due to a suspicion of cancer in her right breast. The CE-MRI showed a 3.1-cm irregular enhanced mass and a 1.1-cm circumscribe mass in the upper outer quadrant of the right breast. Unfortunately, the CE-MRI-guided biopsy had to wait for 1 month due to a busy schedule. The CESM revealed two masses that were consistent with CE-MRI findings. CESM-Bx was performed, and the patient was diagnosed with invasive lobular carcinoma with an irregular mass and fibroadenoma of the circumscribed mass. The patient underwent substantial surgery.
Conclusions:
CESM-Bx is a simple emerging technique that can be used feasibly to obtain tissue proof on the concerned enhanced lesion on CESM. In such cases of silicone-injected breasts, the CESM-Bx can be used as an alternative to MRI-guided biopsy for cancer diagnosis.
The WoundWand and Its Novel Use in Burn Excision Surgery
Authors: Guang H Yim, Zeeshan Ahmad, Steven L A Jeffery
Journal: Eplasty (2015)
Keywords: woundwand, burn, eschar, full thickness, tangential excision
MeSH terms: Case Reports

Objective:
The authors present the novel use of a new generation surgical ablative tool known as the WoundWand.
Methods:
A 66-year-old woman presented with 18% deep-dermal and full-thickness burns affecting the left side of her body including the total left upper limb, abdomen, and left thigh following lighting a cigarette in bed while on home oxygen therapy. She underwent tangential excision of burn using the WoundWand with immediate reconstruction using split skin grafts and topical negative pressure therapy.
Results:
We found that we were able to easily tangentially excise the hard eschar from delicate areas such as the hand and fingers using the WoundWand.
Discussion:
The authors conclude that the novel use of this device particularly in delicate areas such as dorsum of fingers and hand has some advantages over preexisting methods. Further clinical study may add to the surgical armamentarium of the burns surgeon.
Simultaneous Bilateral Quadriceps Tendon Rupture in a Patient with Diffuse Idiopathic Skeletal Hyperostosis after Minimal Trauma: Eight-Year Follow-Up
Authors: Sevan Sıvacıoğlu, Ahmet Salduz, Ufuk Öztürk, Serkan Bayram, Fevzi Birişik
Journal: Case Rep Orthop (2018)
MeSH terms: Case Reports

Introduction:
The purpose of this report was to describe a very rare case of simultaneous bilateral quadriceps tendon rupture seen in a patient who was diagnosed as having diffuse idiopathic skeletal hyperostosis.
Case presentation:
A man aged 64 years presented to the emergency department with bilateral quadriceps tendon rupture. Surgical repair was performed with suture anchors and a stainless steel cable. His legs were immobilized in casts for six weeks. After removal of the casts, physiotherapy was started. Four months after surgery, he was able to walk with 0°-120° range of motion and active extension. He was followed up for 8 years without rerupture or other complications.
Conclusion:
Bilateral rupture of the quadriceps tendon is a rare condition and generally related to metabolic disorders. Diffuse idiopathic skeletal hyperostosis is a metabolic disorder that causes bilateral quadriceps tendon rupture, and it accounted for the differential diagnosis of the underlying condition.
Diabetes in an emergency context: the Malian case study
Authors: Stéphane Besançon, Ibrahima-Soce Fall, Mathieu Doré, Assa Sidibé, Olivier Hagon, François Chappuis, David Beran
Journal: Confl Health (2015)

Background:
The World Health Organization proposes 6 building blocks for health systems. These are vulnerable to challenges in many contexts. Findings from a 2004 assessment of the health system in Mali for diabetes care found many barriers were present for the management and care of this condition. Following this assessment different projects to strengthen the healthcare system for people living with diabetes were undertaken by a local NGO, Santé Diabète.
Case description:
In March 2012, following a Coup in Bamako, the northern part of Mali was occupied and cut-off from the rest of the country. This had a major impact on the health system throughout the country. Due to the lack of response by humanitarian actors, Santé Diabète in close collaboration with other local stakeholders developed a humanitarian response for patients with diabetes. This response included evacuation of children with Type 1 diabetes from northern regions to Bamako; supplies of medicines and tools for management of diabetes; and support to people with diabetes who moved from the north to the south of the country.
Discussion:
It has been argued that diabetes is a good tracer for health systems and based on Santé Diabète's experience in Mali, diabetes could also be used as a tracer in the context of emergencies. One lesson from this experience is that although people with diabetes should be included as a vulnerable part of the population they are not considered as such. Also within a complex emergency different "diabetes populations" may exist with different needs requiring tailored responses, such as internally displaced people versus those still in conflict areas. From Santé Diabète's perspective, the challenge was changing the ways it operated from a development NGO to an emergency NGO. In this role it could rely on its knowledge of the local situation and its function as part of the post-conflict situation.
Conclusion:
The lessons learnt from this experience by Santé Diabète in Mali may be useful for other NGOs and the humanitarian response in general in addressing the challenge of managing non communicable diseases and diabetes in conflict and disaster situations in countries with weak health systems.
Bardet-Biedl Syndrome, Crohn Disease, Primary Sclerosing Cholangitis, and Autoantibody Positive Thyroiditis: A Case Report and A Review of a Cohort of BBS Patients
Authors: Ugur Halac, Denise Herzog
Journal: Case Rep Med (2012)

Bardet-Biedel syndrome (BBS) is a rare autosomal recessive, genetically heterogeneous ciliopathy. Although the disease has been described in a patient with psoriasis, individuals with BBS are not known to be at risk of developing autoimmune disorders. Our objective was to describe a 14-year-old patient with BBS who presented with Crohn disease (CD), primary sclerosing cholangitis (PSC), and thyroiditis in the context of a cohort review at Sainte-Justine Hospital and to alert clinicians to the increased risk of autoimmune disorders in these patients. The cohort contained fifteen patients (9 boys), followed from 1968 to 2009 during a median period of 12 years (range 9 months-26 years). Three of the 15 patients (20%) developed a chronic autoimmune disease: one had juvenile rheumatoid arthritis; a second one had type 1 diabetes mellitus in association with Hashimoto thyroiditis and psoriasis; a third one developed CD, PSC, and Hashimoto thyroiditis. As chronic autoimmune diseases occurred in 20% of our cohort of children with BBS, it is appropriate to keep this association in mind during the followup.
Sporadic neurofibroma of transverse colon in a patient without neurofibromatosis type 1: A case report
Authors: Toru Imagami, Saburo Sugita, Takaya Nagasaki, Masahiro Kimura, Keisuke Ito, Shingo Inaguma
Journal: Int J Surg Case Rep (2020)
Keywords: colon, endoscopy, laparoscopic surgery, neurofibroma
MeSH terms: Case Reports

Introduction:
The occurrence of sporadic colonic neurofibroma particularly in a patient without neurofibromatosis type 1 has been rarely reported. Therefore, the clinical significance of this disease has not been fully elucidated.
Presentation of case:
An 81-year-old woman with a positive fecal occult blood test result was referred to our institution for the evaluation of anemia. On colonoscopy, a 50-mm submucosal tumor-like mass was found in the hepatic flexure of the colon. Superficial biopsy and boring biopsy showed unspecific granulation tissues, and immunostaining revealed that the mesenchymal tumor was negative for CD34, c-kit, desmin, and S100 protein. The patient underwent laparoscopic right colectomy with complete mesocolic excision (CME). Pathologically, the tumor was diagnosed as neurofibroma.
Discussion:
Gastrointestinal neurofibromas are known to cause clinical symptoms. No colonic neurofibroma has been diagnosed before resection. Moreover, neurofibromas, particularly large lesions, reportedly undergo malignant transformation. Surgical extirpation with clear margins is the primary treatment, and laparoscopic surgery is considered acceptable for colonic neurofibroma and colon cancer.
Conclusion:
Based on our experience, a preoperative diagnosis was impossible for colonic neurofibroma. Laparoscopic surgery with CME is considered feasible for sporadic colonic neurofibroma.
Successful treatment of fanconi anemia and T-cell acute lymphoblastic leukemia
Authors: Terrie Flatt, Kathleen Neville, Karen Lewing, Jignesh Dalal
Journal: Case Rep Hematol (2012)
MeSH terms: Case Reports

Fanconi anemia is associated with an increased risk of malignancy. Patients are sensitive to the toxic effects of chemotherapy. We report the case of a patient with Fanconi anemia who developed T-cell acute lymphoblastic leukemia. He experienced chemotherapy-related complications including prolonged neutropenia, grade IV vincristine neuropathy, and disseminated aspergillosis. He was successfully treated with modified dosing of cytarabine and intrathecal methotrexate followed by allogeneic bone marrow transplant. The aspergillosis was treated with systemic antifungal treatment and surgical resection. Now 30 months after bone marrow transplant the patient is without evidence of aspergillosis or leukemia.
Outcomes of Bone Marrow Mononuclear Cell Transplantation for Neurological Sequelae Due to Intracranial Hemorrhage Incidence in the Neonatal Period: Report of Four Cases
Authors: Nguyen Thanh Liem, Truong Linh Huyen, Le Thu Huong, Ngo Van Doan, Bui Viet Anh, Nguyen Thi Phuong Anh, Dang Thanh Tung
Journal: Front Pediatr (2020)
Keywords: autologous, bone marrow mononuclear cells, intracranial hemorrhage, neonate, neurological sequelae
MeSH terms: Case Reports

Aim: The aim of this study was to present primary outcomes of autologous bone marrow mononuclear cell (BMMNC) transplantation to improve neurological sequelae in four children with intracranial hemorrhage (ICH) incidence during the neonatal period. Methods: GMFM88 and modified Ashworth score were used to assess motor function and muscle spasticity before BMMNC transplantation and after transplantation. Brain MRI was performed to evaluate brain morphology before and after BMMNC transplantation. Bone marrow were harvested from anterior iliac crest puncture and BMMNCs were isolated using Ficoll gradient centrifugation. The microbiological testing, cell counting, and hematopoietic stem cell (hHSC CD34+ cell) analysis were performed, following which BMMNCs were infused intrathecally. Results: Improvement in motor function was observed in all patients after transplantation. In addition, muscle spasticity was reduced in all four patients. Conclusion: Autologous BMMNC transplantation may improve motor function and reduce muscle spasticity in children with ICH incidence during the neonatal period.
Comminuted Trapezium Fracture: Case Presentation and Review of Surgical Fixation Techniques
Authors: Amanda F Spielman, Sriram Sankaranarayanan
Journal: Case Rep Orthop (2021)
MeSH terms: Case Reports

We report a case of a 28-year-old male who sustained a comminuted trapezium fracture with carpometacarpal subluxation of the right hand. Treatment with internal fixation with a headless compression screw resulted in excellent outcomes.
Two Cases of Influenza B Virus-Related Fatal Fulminant Pneumonia Complicated With Staphylococcus aureus Infection in China Diagnosed Using Next-Generation Sequencing (2018)
Authors: Bing Bai, Hongyan Wang, Meng Li, Xiaoyu Ma, Jinxin Zheng, Qiwen Deng, Zhijian Yu
Journal: Front Public Health (2020)
Keywords: staphylococcus aureus, fatal pneumonia, influenza b virus, next-generation sequencing, sepsis
MeSH terms: Influenza B virus / genetics, Staphylococcal Infections, Case Reports, Research Support, Non-U.S. Gov't, China, Female, High-Throughput Nucleotide Sequencing, Humans, Staphylococcus aureus / genetics

Two rare cases of Chinese female patients with influenza B virus infection complicated with both fulminant pneumonia and septicemia caused by Panton-Valentine leukocidin(PVL) positive methicillin-sensitive Staphylococcus aureus (MASS) were reported for the first time in China through next-generation sequencing (NGS). An increasing body of evidence indicates that co-infection with influenza B virus and bacterial pneumonia is often fatal. Rapid and precise identification of the co-infection bacteria can guide the selection of treatment for patients with influenza virus infection in the clinical setting. In this study, next-generation sequencing (NGS) was applied for the rapid diagnosis of these two cases. Despite the unfavorable survival outcome of these patients, the application of next-generation sequencing showed promise as a diagnostic tool for the rapid diagnosis of unknown pathogens in patients with bacterial pneumonia and sepsis. This method can guide the administration of medications in such patients.
HIV-ASSOCIATED NON HODGKIN LYMPHOMA: A CASE SERIES STUDY FROM TURKEY
Authors: Kayra Somay, Sidar Çöpür, Emre Osmanbaşoğlu, Helin Masyan, Harun Arslan, Olga Meltem Akay, Süda Tekin, Burhan Ferhanoğlu
Journal: Afr J Infect Dis (2020)
Keywords: human immunodeficiency virus, anti-retroviral therapy, lymphoma, non-hodgkin lymphoma

Background:
Human immunodeficiency virus (HIV) is a global health concern with major risks for opportunistic infections and predisposition to malignancies including Kaposi sarcoma associated with Human Herpes Virus-8 (HHV-8) and non-Hodgkin lymphoma (NHL) commonly associated with Epstein Barr Virus (EBV). Although the exact mechanisms of predisposition to certain malignancies are unclear, HIV (+) cancer patients typically have poorer prognosis.
Materials and methods:
We included all five HIV positive NHL patients receiving antiretroviral therapy (ART) and chemotherapy in our clinic and aim to determine their follow-up outcomes associated with ART.
Results:
The use of ART in conjunction with chemotherapy regimens lead to better therapeutic outcome in our cases with no mortality over three years of follow-up despite high rates of poor prognostic factors and studies demonstrating 1-year survival rates of approximately 30% in HIV-associated lymphoma. No significant adverse effect has been recorded.
Conclusion:
We recommend use of ART along with chemotherapy regimens in HIV positive lymphoma patients for better treatment response.
Perspectives on waiting times in an antenatal clinic: A case study in the Western Cape
Authors: Justine C Baron, Doreen Kaura
Journal: Health SA (2021)
Keywords: barriers to waiting times, facilitators of waiting times, factors influencing waiting times, waiting time, waiting time in antenatal clinic

Background:
Antenatal care (ANC) is vital in reducing maternal and neonatal morbidity and mortality. Globally, 85% of women had one ANC visit with a skilled birth attendant and only 58% received the recommended four ANC visits. Long waiting times (LWTs) in the antenatal clinic affects the utilisation of the service. Long waiting times are viewed as a significant barrier to ANC utilisation and needs further investigation.
Aim:
The aim of this study was to explore and describe the contextual realities within the antenatal clinic that influenced waiting times (WTs).
Setting:
This study was conducted in an antenatal clinic, within a Midwife Obstetric Unit (MOU), Western Cape, South Africa.
Methods:
This study utilised a qualitative methodology with a single case study design with three embedded units of analysis. Purposive sampling was used to recruit the participants. Data were collected through unstructured observation and semi-structured interviews with pregnant women and midwives. Interviews were audio recorded, transcribed and analysed using the framework method.
Results:
The antenatal clinics had LWTs. The barriers to WTs were related to staff factors, patient factors, operational factors, communication, equipment and infrastructure and other research participant recruitment.
Conclusion:
The factors that influenced WTs are multifaceted and interrelated. Many of the factors influencing the WTs could be remedied by implementing appropriate workflow strategies, improving communication and increasing equipment availability. The findings can be used to develop waiting time guidelines and improve WTs in the antenatal clinic.
Acute onset of psychosis in a patient with a left temporal lobe arachnoid cyst
Authors: Alexander Mironov, Sabu John, Jonathan Auerbach, Ghassan Jamaleddine
Journal: Case Rep Med (2014)

Arachnoid cysts are considered a rare neurological tumor, few of which exhibit any symptomatology. A 38-year-old Haitian American female with no past psychiatric history presented with rapid onset of psychosis. Workup for medical etiology proved to be within normal limits, with the exception of a left temporal lobe arachnoid cyst. The purpose of this paper is to add to a number of existing case reports that suggest a relationship between such lesions and psychiatric illness.
A rare mullerian duct anomaly not included in the classification system by the american society for reproductive medicine
Authors: Shereene J Brown, Shawky Z A Badawy
Journal: Case Rep Obstet Gynecol (2013)

This is a case report of a 37-year-old female with a uterine septum (two cavities), a normal single fundal contour, two cervices, and a longitudinal vaginal septum. This is a rare finding that is not described in the current classification system by the American Society for Reproductive Medicine.