OpenMed/multicare-articles huggingface dataset:
Longitudinal Monitoring of Biomechanical and Psychological State in Collegiate Female Basketball Athletes Using Principal Component Analysis
Authors: Joshua A J Keogh, Matthew C Ruder, Kaylee White, Momchil G Gavrilov, Stuart M Phillips, Jennifer J Heisz, Matthew J Jordan, Dylan Kobsar
Journal: Transl Sports Med (2024)

Background:
The growth in participation in collegiate athletics has been accompanied by increased sport-related injuries. The complex and multifactorial nature of sports injuries highlights the importance of monitoring athletes prospectively using a novel and integrated biopsychosocial approach, as opposed to contemporary practices that silo these facets of health.
Methods:
Data collected over two competitive basketball seasons were used in a principal component analysis (PCA) model with the following objectives: (i) investigate whether biomechanical PCs (i.e., on-court and countermovement jump (CMJ) metrics) were correlated with psychological state across a season and (ii) explore whether subject-specific significant fluctuations could be detected using minimum detectable change statistics. Weekly CMJ (force plates) and on-court data (inertial measurement units), as well as psychological state (questionnaire) data, were collected on the female collegiate basketball team for two seasons.
Results:
While some relationships (n = 2) were identified between biomechanical PCs and psychological state metrics, the magnitude of these associations was weak (r = |0.18-0.19|, p < 0.05), and no other overarching associations were identified at the group level. However, post-hoc case study analysis showed subject-specific relationships that highlight the potential utility of red-flagging meaningful fluctuations from normative biomechanical and psychological patterns.
Conclusion:
Overall, this work demonstrates the potential of advanced analytical modeling to characterize components of and detect statistically and clinically relevant fluctuations in student-athlete performance, health, and well-being and the need for more tailored and athlete-centered monitoring practices.
Case Report: Low-grade endometrial stromal sarcoma with intravenous and intracardiac extension: a case after misdiagnosis of endometrial stromal nodule as submucosal fibroid
Authors: Xiao-Shan Chai, Guang-Shi Tao, Hui Ding, Peng Zhou, Xi-Long Mei, Xiao-Xue Li
Journal: Front Oncol (2023)
Keywords: cd10, esn, lg-ess, case report, intravenous and intracardiac extension, uterine fibroids
MeSH terms: Case Reports

We present herein a rare case of large vascular and cardiac metastases of low-grade endometrial stromal sarcoma (LG-ESS) in a female patient, which occurred after misdiagnosis of endometrial stromal nodule (ESN) as submucosal leiomyoma 7 years ago. Preoperative three-dimensional CT reconstruction was used to assess the extent of the lesion. The patient underwent radical resection: thrombectomy and total hysterectomy with bilateral salpingo-oophorectomy without establishing the cardiopulmonary bypass. Intraoperative transesophageal ultrasound (TEE) was used to monitor whether the intracardiac mass was removed completely. To date, this patient is alive without any evidence of recurrence 3 years after surgery. The differential diagnosis of ESN and LG-ESS is often difficult. A clear distinction can only be reliably made after histological analysis of the tumor's entire interface with the neighboring myometrium. This case highlights that follow-ups of patients with ESN are important. Regular follow-up can detect metastasis and recurrence of misdiagnosed LG-ESS as early as possible. Distant metastasis of LG-ESS is rare, especially involving large vessels or the heart. The treatment should largely rely on multidisciplinary cooperation. Although the surgery is traumatic, the perioperative mortality rate is low, and patients can avoid death from congestive heart failure or sudden death.
Diffuse Alveolar Hemorrhage Occurring Suddenly in a Diabetic Patient With Asthma Exacerbation
Authors: Svetoslav Bardarov, Chong Vue, Rochell Santana, Jay Nfonoyim
Journal: Cureus (2024)
Keywords: anatomic and clinical pathology, autopsy pathologist, diffuse alveolar hemorrhage, goodpasture's syndrome, poor asthma outcomes, pulmonary-renal syndrome, teaching in emergency medicine
MeSH terms: Case Reports

Diffuse alveolar hemorrhage (DAH) is a rare but potentially life-threatening condition characterized by bleeding into the alveolar spaces of the lungs. DAH can occur due to a wide range of etiologies including autoimmune diseases, infections, drugs, and malignancies. The clinical presentation is variable and may include cough, dyspnea, fever, and hemoptysis. Diagnosis is often challenging due to the nonspecific symptoms and a lack of definitive diagnostic criteria. Treatment is primarily aimed at addressing the underlying cause and providing supportive care.
Report on a case of liver-originating malignant melanoma of unknown primary
Authors: Zheng Yuan, Hai-Yan Guo, Wei-Ting Lu, Yao-Hui Wang, Jing He, Fan Zhang, Jun-Yong Che, Fei Qiao
Journal: Open Life Sci (2023)
Keywords: diagnosis, liver, malignant melanoma, unknown primary
MeSH terms: Case Reports

Malignant melanoma (MM) frequently occurs in the skin or mucosa, whereas malignant melanoma of unknown primary (MUP) is diagnosed in patients with lymph nodes or visceral organs as the site of origin, where it is challenging to detect the primary lesion by comprehensive examination. MUP is possibly related to the spontaneous regression of the primary lesion. In addition, primary hepatic melanoma (PHM) usually refers to the primary MM occurring in the liver, with no typical primary lesions and no manifestations of tumor metastasis. A 61-year-old male patient with liver as the site of origin was diagnosed with MM by Melan-A, HMB-45, and S-100 immunohistochemistry staining of liver biopsy tissue. Based on a comprehensive examination, no basis was found for melanoma in sites such as the skin, mucosa, five sense organs, brain, digestive tract, respiratory tract, or genitalia, and the patient was subsequently diagnosed with MUP. MMs require a comprehensive inspection, beginning with the liver, to search for the primary lesion; if the primary lesion is not found, the possibility of PHM or MUP should be considered.
Knee Extensor Apparatus Reconstruction with Allograft after Patellar Resection: A Case Report
Authors: Fabio Cosseddu, Martina Cordoni, Elena Bechini, Edoardo Ipponi, Francesco Rosario Campo, Antonio D'Arienzo, Lorenzo Andreani
Journal: Acta Med Litu (2024)
Keywords: allograft, bone metastasis, extensor apparatus, patella, rehabilitation
MeSH terms: Case Reports

Background:
The extensor apparatus of the knee can be thought of a chain that transmits the muscular strength developed by the quadriceps muscles to the proximal tibia. This complex is essential to allow the extension of the tibia over the femur, being essential to provide knee mobility and stability. In case of lesions which irreparably damage the patella, such as a locally aggressive bone tumor, it is necessary to restore both the apparatus' anatomical continuity and its strength.
Case report:
A 39-years-old Caucasian man with a history of lung carcinoma developed atraumatic swelling and soreness in his left knee. Imaging evidence reported a degeneration of the left patella. We performed an en bloc resection of the patella and the nearby soft tissues of the extensor apparatus. The resulting gap was fulfilled with a massive allograft consisting of a quadriceps tendon, a patella and a patellar ligament. No complication or local recurrences were observed. At the patient's latest follow-up, he did not have any extension lag and quadriceps strength was completely restored.
Conclusion:
Massive allografts can represent a reliable alternative for the reconstruction of the patella and the knee extensor apparatus in orthopedic oncology.
Microvascular decompression for intermediate nerve neuralgia: a case report and literature review
Authors: Kan Wang, Wenhao Li, Yujie Bo, Biao Li, Jinxin Wan, Luyan Mu, Yuwen Song
Journal: Front Surg (2024)
Keywords: functional neurosurgery, intermediate nerve, intermediate nerve neuralgia, microvascular decompression, otalgia
MeSH terms: Case Reports

Intermediate nerve neuralgia (INN) is a rare craniofacial pain syndrome. The diagnosis of INN is challenging because of the complex ear sensory innervation that results in a clinical overlap with both trigeminal neuralgia (TN) and glossopharyngeal neuralgia (GPN). A 76-year-old woman with a remarkable medical history presented with right otalgia and mandibular pain for 7 years. Neurological examination revealed a diminished sensation in the distribution of the intermediate nerve (IN). Magnetic resonance imaging demonstrated an impression of the anterior inferior cerebellar artery (AICA) on the facial-vestibulocochlear nerve complex (VII/VIII complex). The patient underwent microvascular decompression (MVD) after long-term oral medication. We confirmed that the responsible vessel was close to the VII/VIII complex and isolated the vessel under the microscope via a right-sided suboccipital retrosigmoid approach. The patient's otalgia and mandibular pain disappeared after the operation. There were no additional neurological deficits. In conclusion, MVD is a safe and feasible option for patients with INN who fail to respond to adequate pharmacotherapy.
Case Report: Telitacicept in severe myasthenia gravis: a case study with multiple autoantibodies
Authors: Qian Guo, Yusen Huang, Fangruyue Wang, Le Fang
Journal: Front Immunol (2023)
Keywords: achr-ab, ryr-ab, telitacicept, titin-ab, case report, myasthenia gravis
MeSH terms: Myasthenia Gravis / diagnosis, Myasthenia Gravis / drug therapy, Thymoma, Thymus Neoplasms, Case Reports, Acetylcholinesterase, Aged, Autoantibodies, Connectin, Female, Humans, Connectin, telitacicept, Acetylcholinesterase, Autoantibodies

Multi-antibody-positive myasthenia gravis (MG) presentations are relatively rare, often found in older patients, and generally predict a poor prognosis. We report a case of a female patient with generalized MG, testing positive for Titin antibodies (Titin-Ab), ryanodine receptor antibodies (RyR-Ab), and acetylcholine receptor antibodies (AChR-Ab), and resistant to acetylcholinesterase inhibitors. Following unsuccessful traditional therapies, she received Telitacicept, leading to significant improvements. This case underscores Telitacicept's potential efficacy for similar patients and offers insights into the clinical characteristics of multi-antibody MG.
Multivisceral resection of nonfunctional pancreatic neuroendocrine neoplasm with nearby organ invasion: a case report
Authors: Cong Zhang, Weiqiao Niu, Yaopeng Xu, Yijie Lu, Lining Huang, Song Li, Xinwei Jiang, Jianwu Wu
Journal: Front Endocrinol (Lausanne) (2023)
Keywords: debulking surgery, invasion, liver metastasis, multivisceral resection, pancreatic neuroendocrine neoplasm
MeSH terms: Neuroectodermal Tumors, Primitive / pathology, Neuroectodermal Tumors, Primitive / surgery, Neuroendocrine Tumors / pathology, Neuroendocrine Tumors / surgery, Pancreatic Neoplasms / pathology, Pancreatic Neoplasms / surgery, Case Reports, Research Support, Non-U.S. Gov't, Aged, Humans, Male, Neoplastic Processes, Pancreas / pathology, Pancreas / surgery

Pancreatic neuroendocrine neoplasms (pNENs) are relatively rare epithelial malignancies originating from pancreatic neuroendocrine cells, pathologically classified into well-differentiated pancreatic neuroendocrine tumors (pNETs) and poorly-differentiated pancreatic neuroendocrine carcinoma (pNECs). Although they also fall under the category of pNENs, the almost entirely distinct biological characteristics and survival prognosis have caused debate among surgeons when it comes to the development of surgical intervention options, particularly for locally advanced G3 pNETs and pNECs. We present a case of 66-year-old male with nonfunctional G3 pNET, invasion of five nearby pancreatic organs and type II liver metastases. The patient achieved good outcomes after undergoing multivisceral resection and postoperative adjuvant chemotherapy. This finding helps surgeons better understand locally advanced pNENs, formulate treatment decisions systematically and confidently, and balance patient benefits and risks of surgery.
Case report: Pellagra presentation with dermatitis and dysphagia
Authors: Segenet Bizuneh Mengistu, Iman Ali, Hiwot Alemu, Endalkachew Belayneh Melese
Journal: Front Med (Lausanne) (2024)
Keywords: case report, dermatitis, dysphagia, global health, pellagra
MeSH terms: Case Reports

Pellagra is a disorder caused by a deficiency of niacin or tryptophan, manifested by characteristic dermatitis on sun-exposed areas of the skin. Gastrointestinal involvement is common, and symptoms include glossitis, stomatitis, and diarrhea. Neurologic symptoms can occur in some patients, including dementia, anxiety, depression, tremors, hyporeflexia and, in severe cases, encephalopathy. We present the case of a woman with hyperpigmentation and hyperkeratosis on sun-exposed areas of the skin along with progressive dysphagia. Notably, she did not report diarrhea or any neurologic or psychiatric symptoms. Her symptoms were most consistent with pellagra, and niacin supplementation was initiated, leading to recovery. This case report highlights that dermatitis and dysphagia, the main gastrointestinal manifestations, can be the only symptoms in patients with pellagra, requiring a high index of suspicion in dermatologic settings to diagnose and treat this fatal condition early.
Case Report: First case of HIV, hepatitis B, hepatitis C, and Vibrio vulnificus coinfection
Authors: Huimin Zeng, Jialong Guan, Chudan Liang, Yulong Wang, Lizhi Feng, Han Zhao, Linjin Fan, Xiaofeng Yang, Nenglang Pan, Zequn Wang, Haolan He, Zhimin Chen, Jun Qian, Yueping Li, Linna Liu
Journal: Front Cell Infect Microbiol (2023)
Keywords: hiv, vibrio vulnificus, hamster models, hepatitis b, hepatitis c
MeSH terms: Coinfection / complications, Coinfection / diagnosis, HIV Infections / complications, Hepatitis B, Hepatitis C, Vibrio Infections / diagnosis, Vibrio Infections / therapy, Vibrio vulnificus, Case Reports, Research Support, Non-U.S. Gov't, Humans, Male, Middle Aged

Our patient, a 48-year-old man from Guangdong's coastal region, worked selling and processing oysters and other seafood. He started experiencing swelling and pain in his left knee on October 4, 2022, and they got worse over time. The findings of mNGS test showed Vibrio vulnificus infection. The patient had AIDS, hepatitis A and hepatitis B concurrently. He was admitted to the hospital's intensive care unit (ICU) for treatment as his symptoms worsened. We refrained from performing an amputation because the family members expressed a desire to keep the limb. The limb was managed with regular dressing changes, thorough debridement, wound closure, ongoing VSD drainage, and local antibiotic irrigation. The patient's organ function eventually returned to normal, and the systemic infection got better. On November 1, the wound's new granulation tissue had grown well and had gradually crept to cover 80% of the wound. The tissue's blood flow had also improved, indicating a trend of growth and healing.
Zygomatic Implant-Supported Prosthetic Rehabilitation of a Patient with Post-COVID-19 Mucormycosis and Maxillectomy
Authors: Rewa Kawade, Seema Sathe, Anjali Bhoyar, Bhushan Mundada, Neeraj Chachediya, Aditee Apte
Journal: Case Rep Dent (2024)
MeSH terms: Case Reports

Mucormycosis has been prevalent in the past few years with the COVID-19 pandemic largely affecting the maxilla due to its proximity to the respiratory corridor. Resection of the maxillary dentition along with the maxillary bone itself has a huge psychosocial impact on the patient. When seeking prosthetic rehabilitation, poor esthetics, difficulty in mastication, and social embarrassment are the patients' concerns. Hence, it becomes great responsibility for the clinician to restore the patient's natural teeth while causing him/her minimum discomfort. This article describes such a case of post-COVID-19 mucormycosis that has been provisionally restored by the means of all-on-four zygomatic implants.
Slide tracheoplasty for congenital tracheal stenosis with involvement of the carina and bronchi: a case report
Authors: Fabio Eiti Nishibe Minamoto, Mariana Rodrigues Cremonese, Eduardo de Campos Werebe, Victor Nudelman, Helio Minamoto
Journal: Einstein (Sao Paulo) (2024)
MeSH terms: Bronchi / abnormalities, Bronchi / diagnostic imaging, Bronchi / surgery, Extracorporeal Membrane Oxygenation / methods, Plastic Surgery Procedures / methods, Trachea / abnormalities, Trachea / diagnostic imaging, Trachea / surgery, Tracheal Stenosis / congenital, Tracheal Stenosis / diagnostic imaging, Tracheal Stenosis / surgery, Case Reports, Female, Humans, Infant, Newborn, Treatment Outcome

A female newborn presented with respiratory distress at birth and was diagnosed with congenital tracheal stenosis. The stenosis was positioned at the distal trachea and compromised the carina and the right and left bronchi. She underwent surgical treatment using circulatory life support with veno-arterial peripheral extracorporeal membrane oxygenation, and the airway was reconstructed using the slide tracheoplasty technique to build a neocarina. The patient had an excellent postoperative course, was successfully weaned from extracorporeal membrane oxygenation and invasive ventilation, and was discharged.
Ciliary Functional Analysis in Chronic Rhinosinusitis with Polyps after Multimodal Intervention: Oral Corticosteroid, Functional Endoscopic Sinus Surgery, and Omalizumab Injection
Authors: Lionel Benchimol, Olivier Bouchain, Noemie Bricmont, Romane Bonhiver, Celine Kempeneers, Philippe Lefebvre, Anne-Lise Poirrier
Journal: Case Rep Otolaryngol (2024)
MeSH terms: Case Reports

In her late 50 s, a woman with a medical history of endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps (CRSwNP) experienced a relapse of nasal polyps, significantly impacting her breathing and sense of smell. She underwent a multifaceted treatment approach, including oral corticosteroids, functional endoscopic sinus surgery, and omalizumab injections. Digital high-speed videomicroscopy (DHSV) revealed only partial improvement in ciliary beat pattern and ciliary beat frequency with oral corticosteroid treatment, while significant improvement in these ciliary parameters was observed with omalizumab injections. Furthermore, administration of omalizumab resulted in a decrease in her SNOT-22 (Sinonasal Outcome Test 22) score. Notably, this case report represents the first study investigating ciliary function using DHSV in a patient treated with omalizumab.
Neonatal Sacrococcygeal Fetiform Teratoma Containing Bowel: A Case Report
Authors: Ashley Toms, Tarlia Rasa Govender, Giulia Brisighelli, Derek Harrison
Journal: European J Pediatr Surg Rep (2024)
Keywords: fetiform teratoma, fetus-in-fetu, germ cell tumor, sacrococcygeal teratoma
MeSH terms: Case Reports

A fetiform sacrococcygeal teratoma (homunculus) is a highly differentiated subgroup of mature cystic teratoma that resembles a malformed fetus. These tumors originate at the base of the coccyx and may vary in their intrapelvic and extrapelvic extent and location. It is important to differentiate this anomaly from fetus-in-fetu which has a higher degree of structural organization. A 5-day-old neonate presented with a type II sacrococcygeal fetiform teratoma. The mass contained both cystic and solid components. Upon surgical excision and coccygectomy, fully formed bowel was found inside the mass, as well as bones and other well-defined structures. The tumor was confirmed to be fully excised and no malignant or immature features were found on histopathological examination. The patient was last seen growing well with an alpha-fetoprotein of 3.5 μg/L, 14 months after resection.
Robot-Assisted Laparoscopic Radical Prostatectomy for Prostatic Metastatic Recurrence from Testicular Cancer
Authors: Kohei Hirose, Yasukazu Nakanishi, Ryo Andy Ogasawara, Naoki Imasato, Sao Katsumura, Madoka Kataoka, Shugo Yajima, Hitoshi Masuda
Journal: Case Rep Urol (2024)
MeSH terms: Case Reports

Introduction:
Treatment evidence for malignancies metastatic to the prostate in young patients is scarce. Herein, we present a case of prostatic metastasis from testicular cancer treated with induction chemotherapy followed by robot-assisted radical prostatectomy. Case Presentation. The patient is a 34-year-old male who underwent radical orchiectomy for a left testicular tumor two years ago and was diagnosed with a mixed germ cell tumor. He was followed up without adjuvant therapy, but symptoms of dysuria lead to suspicion of a prostate tumor, which was diagnosed by prostate biopsy as seminoma of the prostate. After four cycles of chemotherapy, normalization of tumor markers, and tumor shrinkage on imaging, he underwent robot-assisted radical prostatectomy. No recurrence has been observed nine months after treatment.
Conclusion:
In men with a history of testicular cancer presenting with lower urinary tract symptoms, it is important to consider recurrent prostate metastases.
Intrapericardial Diaphragmatic Hernia Following the Convergence Procedure for Atrial Fibrillation
Authors: Muhammad Almas Baig, Muhammad Haseeb Ul Rasool, Arslan Ahmad, Daniel Miller, Hazem Abosheaishaa, Muhammad Burhan Majeed Rana
Journal: Cureus (2024)
Keywords: atrial fibrillation, convergence procedure, diaphragmatic hernia, pericardial hernia, robotic surgery
MeSH terms: Case Reports

This case report highlights a very rare variant of diaphragmatic hernia, namely, an intrapericardial diaphragmatic hernia, which can arise as a complication of the convergence procedure. A 77-year-old man, presenting with chronic shortness of breath and fatigue, was unexpectedly found to have herniation of the transverse colon into the pericardial cavity through a diaphragmatic-pericardial defect. The diaphragmatic defect was repaired with mesh via robotic surgery. The patient reported resolution of his symptoms at the six-month follow-up.
ALK-rearranged and EGFR wild-type lung adenocarcinoma transformed to small cell lung cancer: a case report
Authors: Rui Chen, Yan Jian, Yuzhen Liu, Junping Xie
Journal: Front Oncol (2024)
Keywords: alk-tkis, liver metastasis, non-small cell lung cancer, small cell lung cancer, transformation
MeSH terms: Case Reports

Background:
Cases of ALK-rearranged EGFR wild-type lung adenocarcinoma (LUAD) transforming into small cell lung cancer (SCLC) are rarely reported, and diagnosis is often delayed. The emergence of this transformation phenomenon is often regarded as a consequence of acquired resistance mechanisms.
Case presentation:
A 47-year-old male diagnosed with poorly differentiated adenocarcinoma of the right middle lung (pT2N2M0, stage IIIA) achieved a 46-month progression-free survival (PFS) following surgery and adjuvant chemotherapy. During routine follow-up, tumor recurrence and metastasis was detected. Genetic testing revealed ALK rearrangement and wild-type EGFR, prompting treatment with ALK-TKIs. In May 2023, abdominal CT scans showed significant progression of liver metastases and abnormal elevation of the tumor marker NSE. Immunohistochemical results from percutaneous liver biopsy indicated metastatic SCLC.
Results:
After resistance to ALK-TKIs and transformation to SCLC, the patient received chemotherapy combined with immunotherapy for SCLC, but the patient's disease progressed rapidly. Currently, the patient is being treated with albumin-bound paclitaxel in combination with oral erlotinib and remains stable.
Conclusion:
Histological transformation emerges as a compelling mechanism of resistance to ALK-TKIs, necessitating the utmost urgency for repeat biopsies in patients displaying disease progression after resistance. These biopsies are pivotal in enabling the tailor-made adaptation of treatment regimens to effectively counteract the assorted mechanisms of acquired resistance, thus optimizing patient outcomes in the battle against ALK-driven malignancies.