OpenMed/multicare-articles huggingface dataset:
Replacement of Anterior Composite Resin Restorations Using Conservative Ceramics for Occlusal and Periodontal Rehabilitation: An 18-Month Clinical Follow-Up
Authors: Leonardo Fernandes da Cunha, Rayane Alexandra Prochnow, Adriana Osten Costacurta, Carla Castiglia Gonzaga, Gisele Maria Correr
Journal: Case Rep Dent (2016)

This case report describes a patient with discolored and fractured composite resin restorations on the anterior teeth in whom substitution was indicated. After wax-up and mock-up, the composite was removed and replaced with minimally invasive ceramic laminates. An established and predictable protocol was performed using resin cement. Minimally invasive ceramic restorations are increasingly being used to replace composite restorations. This treatment improves the occlusal and periodontal aspects during the planning and restorative phases, such as anterior guides, and laterality can be restored easily with ceramic laminates. In addition, the surface smoothness and contour of ceramic restorations do not affect the health of the surrounding periodontal tissues. Here we present the outcome after 18 months of clinical follow-up in a patient in whom composite resin restorations in the anterior teeth were replaced with minimally invasive ceramic laminates.
Reconstruction of the Occipital and Parietal Congenital Defect with 3D Custom-Made Titanium Prosthesis: A Case Report with Four and a Half Years of Follow-Up and a Brief Review of Literature
Authors: Farnoush Mohammadi, Abbas Azari, Nariman Nikparto, Heliya Ziaei
Journal: Case Rep Dent (2021)
MeSH terms: Case Reports

Management of patients with congenital skull defects requires a multidisciplinary approach. Considering the defect's location and size, brain protection, and the cosmetic outcome makes such reconstructions challenging. Due to limited resemblance to skull contour and donor site morbidity of autogenous bone grafts, alloplastic materials are widely used for skull reconstructions. Titanium alloys have proper strength values, low infection rates, favorable osseointegration property, and excellent marginal adaptability when manufactured by computer-aided design (CAD) and computer-aided manufacturing (CAM). A 13-year-old female patient presented with congenital defects at the superior third of occipital bone and posterior thirds of the bilateral parietal bones. On CT scan, the exact size and shape of the defect were determined. Using CAD/CAM, a 3D virtual model of the prosthesis was designed and then printed with titanium alloy (TiAl6V4) via additive manufacturing method. The prosthesis was placed on the defect in a total surgery time of only 90 minutes. On 4.5 years of follow-up, the contour of the skull was ideal and the skin over the defect and neurologic status was intact. Due to their biocompatibility and rigidity, custom-made titanium prostheses are promising options for reconstructing complex skull defects.
Abdominal tuberculosis misdiagnosed as acute surgical abdomen and carcinomatosis
Authors: Edinson Dante Meregildo-Rodriguez, Rosita Claudia Tafur-Ramirez, Walter Giovanny Espino-Saavedra, Sonia Fiorella Angulo-Prentice
Journal: F1000Res (2021)
Keywords: acute abdomen, cancer, gastrointestinal tuberculosis, neoplasm, tuberculosis, tuberculous peritonitis
MeSH terms: Abdomen, Acute / diagnosis, Abdomen, Acute / etiology, Peritoneal Neoplasms / diagnosis, Peritoneal Neoplasms / surgery, Tuberculosis / diagnosis, Case Reports, Abdomen, Diagnostic Errors, Humans

Tuberculosis is a major public health problem worldwide. Tuberculosis can be confused with other diseases and its diagnosis is frequently delayed, especially in areas of low prevalence. Abdominal tuberculosis includes involvement of the gastrointestinal tract, peritoneum, lymph nodes, and/or solid organs; and accounts for 5% of all cases of tuberculosis. We report two cases of young patients who presented preoperatively as acute abdomen due to acute appendicitis. During surgery, these cases were misdiagnosed as "carcinomatosis", and in the postoperative period these cases were complicated with septic shock. In both cases, histopathology showed caseating granulomas which suggested tuberculous peritonitis and enteritis. Subsequently, RT-PCR in peritoneal fluid confirmed Mycobacterium tuberculosis. In one case the clinical response to treatment was excellent, and the other case was fatal. The aim of this report is to bring attention to the spectrum of tuberculosis, and to serve as a reminder of tuberculosis as the great imitator that can masquerade as cancer. Most tuberculous patients erroneously diagnosed as cancer have extensive "neoplastic" lesions that would suggest an advanced-stage malignancy. Assuming a case as an advanced cancer would reduce the chance of performing more exhaustive studies to get a definitive diagnosis and clinicians would be tempted to offer only palliative treatments.
22q11 Deletion Syndrome and Urogenital Manifestations: A Clinicopathological Case Report
Authors: M Vachette, G E Grant, J Bouquet de la Joliniere, M Jotterand, N Ben Ali, A Feki, R Capoccia Brugger
Journal: Front Med (Lausanne) (2016)
Keywords: 22q11 deletion syndrome, catch22 syndrome, digeorge syndrome, hypospadias, renal agenesis, urogenital manifestations
MeSH terms: Case Reports

Background:
Deletion in the chromosomal region 22q11 results from the abnormal development of the third and fourth pharyngeal pouches during embryonic life and presents an expansive phenotype with more than 180 clinical features described that involve every organ and system.
History and signs:
A 23-year-old African woman presented for the first trimester echography, which revealed an isolated anechoic structure suggesting a ureteral dilatation. The suspicion of a malposition of great arteries in the second trimester indicated an amniocentesis leading to a diagnosis of 22q11 deletion.
Outcome:
At 32 weeks, the patient was admitted for premature rupture of membranes and gave birth 2 weeks later to a male newborn who presented a respiratory distress syndrome and probably died secondary to a tracheal stenosis. Necropsy revealed typical clinical features of 22q11 deletion associated with left renal agenesis, hypospadias, and penile hypoplasia.
Conclusion:
We report a case of 22q11 deletion syndrome with typical clinical features associated with urogenital manifestations suspected at the first trimester ultrasound.
When to Suspect DRUJ's Instability in Children? Case Report of a Rare Presentation of Distal Forearm Fractures
Authors: Claire-Anne Saugy, Aline Bourgeois Bregou
Journal: European J Pediatr Surg Rep (2022)
Keywords: children, forearm fracture, galeazzi-equivalent injury, distal radioulnar joint
MeSH terms: Case Reports

Pediatric displaced distal metaphyseal ulnar fractures and distal radial buckle fractures are common. However, to the best of our knowledge, their association has never been specifically reported. Thus, classification and management of this pattern remain challenging especially in young children. Distal radioulnar joint (DRUJ)'s assessment is difficult. A Galeazzi-equivalent injury should be suspected. We report the case of a 2-year-old boy who presented the above-mentioned association of forearm fractures and compare our management with actual recommendations. We would recommend a low-suspicion threshold for DRUJ's instability in young children presenting with displaced distal metaphyseal ulnar fracture associated with distal radial buckle fracture. That suspicion should raise the necessity of appropriate treatment and follow-up.
Radiation Recall Dermatitis following Radioactive Iodine Therapy: A New Observation
Authors: Ikechukwu Chidobem, Tahereh Orouji Jokar, Chisom Mgbodile, Francis Mgbodile, Ghassan Bassil, Nazia Khan
Journal: Case Rep Oncol Med (2021)
MeSH terms: Case Reports

A 47-year-old female, who had previously received adjuvant right breast radiation for ductal carcinoma in situ, presented with right breast edema, erythema, and pain. This developed about two and a half weeks following radioactive iodine therapy for thyroid carcinoma. A biopsy was performed to rule out malignancy, since inflammatory breast cancer can present with similar symptoms. This confirmed radiation recall dermatitis (RRD) as the most likely diagnosis. RRD is an inflammatory reaction occurring in a previously irradiated field and was first described in 1959. Subsequent reports in the literature have associated it with the administration of other drugs, mostly chemotherapy. To our knowledge, this is the first reported case of RRD following radioactive iodine therapy.
Invasive Aspergillosis in a Patient with Stage III (or 3a or 3b) Non-Small-Cell Lung Cancer Treated with Durvalumab
Authors: Ashish Gupta, Aung Tun, Katy Ticona, Aam Baqui, Elizabeth Guevara
Journal: Case Rep Oncol Med (2019)
MeSH terms: Case Reports

Durvalumab is a therapeutic monoclonal antibody that blocks the checkpoint inhibitor, programmed death ligand 1 (PD-L1), resulting in T-cell activation and an antitumor response. Durvalumab is approved for patients with unresectable stage III non-small-cell lung cancer (NSCLC) which has not progressed following platinum-based chemoradiotherapy. A 63-year-old man presented to the emergency department with a 15-day history of increasing shortness of breath. Several months previously, he had been diagnosed with a poorly differentiated stage IIIB NSCLC. He had completed six cycles of chemotherapy with paclitaxel and carboplatin and four cycles of immunotherapy with durvalumab 13 days before his emergency hospital admission. Computed tomography (CT) imaging showed a large left-sided loculated hydropneumothorax suggestive of empyema, patchy opacification of the left lung, and a left upper lobe lung mass. Histology of the cell block from the pleural fluid and decorticated lung tissue showed hyphae suggestive of invasive Aspergillus fumigatus. Treatment with voriconazole resulted in clinical improvement. To our knowledge, this is the first reported case of pleural aspergillosis in a patient treated with durvalumab. However, the increasing use of immune checkpoint inhibitors in oncology requires increased awareness by clinicians of immune-related adverse events (irAEs) due to opportunistic infection.
Successful extracorporeal membrane oxygenation for postoperative cardiopulmonary failure in newborns with congenital diaphragmatic hernia: case reports and literature reviews
Authors: Song-Ming Hong, Xiu-Hua Chen, Si-Jia Zhou, Jun-Jie Hong, Yi-Rong Zheng, Qiang Chen, Jin-Xi Huang
Journal: Front Pediatr (2023)
Keywords: cardiopulmonary failure, congenital diaphragmatic hernia, extracorporeal membrane oxygenation, newborn, postoperative

Introduction:
Congenital diaphragmatic hernia (CDH) is a structural defect caused by inadequate fusion of the pleuroperitoneal membrane that forms the diaphragm, allowing peritoneal viscera to protrude into the pleural cavity. Up to 30% of newborns with CDH require extracorporeal membrane oxygenation (ECMO) support. As with all interventions, the risks and benefits of ECMO must be carefully considered in these patients. Cardiopulmonary function has been shown to worsen rather than improve after surgical CDH repair. Even after a detailed perioperative assessment, sudden cardiopulmonary failure after surgery is dangerous and requires timely and effective treatments.
Method:
Three cases of cardiopulmonary failure after surgical CDH treatment in newborns have been reported. ECMO support was needed for these three patients and was successfully discontinued. We report our treatment experience.
Conclusion:
ECMO is feasible for the treatment of postoperative cardiopulmonary failure in newborns with CDH.
Hiccups induced by aripiprazole combined with sertraline in an adolescent with olfactory reference disorder: A case report
Authors: Zhe Li, Zhenzhen Xiong, Xingmei Jiang, Zhixiong Li, Yiwen Yuan, Xiao Li
Journal: Front Psychiatry (2022)
Keywords: aripiprazole, case report, hiccup, olfactory reference disorder, sertraline
MeSH terms: Case Reports

Background:
Hiccup can cause significant distress to patients and affect medication compliance. Individuals with olfactory reference disorder (ORD) who might develop persistent hiccups when treated with a combination of antidepressant and antipsychotic, leading to significant distress and impairment.
Case summary:
We report a rare case of an adolescent with ORD who was treated with aripiprazole combined with sertraline and who began to hiccup persistently after 6 days on this treatment. He stopped hiccupping after the aripiprazole had been suspended for 12 h. After discharge, the patient continued on sertraline alone and reported no hiccupping at 1-month follow-up.
Conclusion:
Clinicians should consider that the combination of aripiprazole and sertraline can induce hiccups during the acute administration period in adolescents with ORD.
Coinfection of Aspergillus and Cryptococcus in Immunocompromised Host: A Case Report and Review of Literature
Authors: Daniel W Awari, Aditya S Shah, Amber M Sexton, Matthew A Sexton
Journal: Case Rep Infect Dis (2020)
MeSH terms: Case Reports

Management of infections in the immunocompromised patient requires unique considerations that are not typically seen in the immunocompetent. Immunocompromised hosts require a broad set of differential diagnoses when presenting with febrile illness involving a wide variety of microbiology. Moreover, fungal infections are common, and cotreatment of fungal and bacterial infections occurs with regularity. Fungal coinfection, however, is rare. Here, we describe a patient with Aspergillus and recurrent Cryptococcus neoformans coinfection following completion of treatment for pulmonary cryptococcosis.
Lead poisoning in a 6-month-old infant: a case report
Authors: Yifei Duan, Lingyi Yan, Zhengxiang Gao, Yu Gou
Journal: Front Public Health (2023)
Keywords: hu wang fen, blood lead level, lead, lead poisoning, traditional chinese medicine
MeSH terms: Lead Poisoning / diagnosis, Lead Poisoning / etiology, Lead, Case Reports, Research Support, Non-U.S. Gov't, Child, Female, Humans, Infant, Medicine, Chinese Traditional, Mothers, Lead

Background:
Lead is a toxic element of the environment that leads to major complications once it enters the blood stream, affecting multiple organs and systems of the body.
Methods:
We present a case of a 6-month-old female infant diagnosed with lead poisoning after presenting for routine child health care. The child's mother denied that the infant had a history of exposure to lead-containing substances. After a month of calcium supplementation, the patient's blood lead level remained elevated. We then tested the blood lead level of the mother and father. The results showed that the blood lead level of the mother was 77.0 μg/L and that of the father was 36.9 μg/L. The high blood lead level of the mother attracted our attention. We found that the mother had been using an external traditional Chinese medicine, Hu Wang Fen, which contains lead. After the mother's discontinuation of use of the traditional medicine, the child was treated with symptomatic treatment and chelation therapy. Subsequently, the patient's blood lead level decreased significantly.
Results:
Lead toxicity can be a life-threatening problem because of its potential for severe complications. In children, there is no safe blood lead level, and the toxic effects of lead can be prevented by the awareness and avoidance of traditional Chinese medicines that may contain lead.
Conclusion:
Even though the diagnosis of lead poisoning remains difficult in children, it must be taken into consideration by the clinician when treating a child using traditional Chinese medicines.
Case Report: Bosworth Fracture-Dislocation managed by Closed Reduction and Conservative Treatment
Authors: Wan-Bo Ji, Yao-Feng Xu, Zhen Lu
Journal: Front Surg (2022)
Keywords: bosworth fracture-dislocation, closed reduction and casting, conservative treatment approach, irreducible, manipulation
MeSH terms: Case Reports

Bosworth fracture-dislocation is a rare type of ankle injury, which in the typical radiologic are overlap of distal tibia and fibula in the anteroposterior view, posterior subluxation of the talus and syndesmosis dissociation in the lateral view, while in the CT scan, the fibula was displaced behind the posterior edge of the fibular notch (incisura tibiae), locked between the distal tibia and the displaced posterior malleolus fragment. Treatment can be challenging owing to the ignorance or failure of the initial reduction, resulting in an irreducible tibiotalar joint and tibiofibular syndesmosis reduction. To treat this complicated injury, emergent open surgery is always recommended for the first stage reduction to prevent adverse events. Successful closed reduction and conservative treatment of Bosworth fracture-dislocation is rare. This unique case presents a 25-year-old male with a Bosworth fracture-dislocation cured with closed reduction and U-shaped plaster splint. The patient was fully weight bearing and had no pain, and there were no limitations in the range of motion of the ankle and subtalar joints at 30 months of follow-up.
Acute massive congestive ischaemic colitis related to inferior mesenteric arteriovenous malformation
Authors: Bruno Coulier, Jean-François De Wispelaere, Isabelle Bueres, Frédéric Pierard, Fabrice Cedric Deprez, Philippe Maldague, Marc van Hoof, Isabelle Gielen
Journal: BJR Case Rep (2016)
MeSH terms: Case Reports

We report a very rare case of acute congestive ischaemic colitis of the left colon caused by brutal decompensation of an uncommon arteriovenous malformation (AVM) in the territory of the inferior mesenteric artery (IMA) in a 45-year-old male patient. The patient presented with severe abdominal pain in the left iliac fossa and abundant mucoid stools. The diagnosis of congestive colitis was made by optical colonoscopy but the full diagnosis of the responsible AVM in the IMA territory was made by contrast-enhanced multidetector CT scan combined with colour Doppler ultrasound. Two successive attempts at selective embolization failed to resolve the symptoms and finally, extensive surgery was necessary. The complete imaging findings of the case are presented and the characteristic features of uncommon AVMs and fistulas of the IMA territory are briefly reviewed.
Case Report: Necrotizing fasciitis caused by Staphylococcus aureus positive for a new sequence variant of exfoliative toxin E
Authors: Artur J Sabat, Marjan Wouthuyzen-Bakker, Angelique Rondags, Laura Hughes, Viktoria Akkerboom, Olga Koutsopetra, Alexander W Friedrich, Erik Bathoorn
Journal: Front Genet (2022)
Keywords: ete, ete2, pvl, staphylococcus aureus, necrotizing fasciitis
MeSH terms: Case Reports

Objectives: Necrotizing fasciitis (NF) caused by S. aureus is a rare, aggressive and rapidly progressing superficial fascia infection with a high mortality rate. The aim of this study was to identify virulence-related genes from a complete genome sequence of a methicillin-susceptible S. aureus (MSSA) isolate recovered from a monomicrobial case of NF. Materials and methods: The MSSA isolate UMCG579 was cultured from a pus collection from the subcutis of a patient with NF. The genome of isolate UMCG579 was sequenced using MinION (Oxford Nanopore) and MiSeq (illumina) platforms. Results: The genome of the UMCG579 isolate was composed of a 2,741,379 bp chromosome and did not harbor any plasmids. Virulence factor profiling identified multiple pore-forming toxin genes in the UMCG579 chromosome, including the Panton-Valentine leukocidin (PVL) genes, and none of the superantigen genes. The UMCG579 isolate harbored a new sequence variant of the recently described ete gene encoding exfoliative toxin (type E). A search in the GenBank database revealed that the new sequence variant (ete2) was exclusively found among isolates (n = 115) belonging to MLST CC152. While the majority of S. aureus ete-positive isolates were recovered from animal sources, S. aureus ete2-positive isolates originated from human carriers and human infections. Comparative genome analysis revealed that the ete2 gene was located on a 8777 bp genomic island. Conclusion: The combination of two heterogeneously distributed potent toxins, ETE2 and PVL, is likely to enhance the pathogenic ability of S. aureus isolates. Since anti-virulence therapies for the treatment of S. aureus infections continue to be explored, the understanding of specific pathogenetic mechanisms may have an important prophylactic and therapeutic value. Nevertheless, the exact contribution of ETE sequence variants to S. aureus virulence in NF infections must be determined.
Acute Kidney Injury Secondary to Necrotizing Sarcoid Granulomatosis
Authors: Varun Mamidi, Manikantan Shekar, Jaiju James Chakola, Vamsi Krishna Makkena, Jayakumar Matcha
Journal: Case Rep Nephrol (2019)
MeSH terms: Case Reports

Background:
Sarcoidosis is a chronic disease characterized by noncaseating lesions involving any organ and tissue in the body. Hypercalcemia and acute kidney injury is a common renal presentation of sarcoidosis. Necrotizing sarcoid granulomatosis (NSG) is a granulomatous disease entity which presents with nodular masses of sarcoid like granuloma which primarily effects the lungs. It is a rare necrotizing variant of sarcoidosis. Extra pulmonary presentation of NSG is very rare.
Case presentation:
We present a 36-year-old female with hypercalcemia and acute kidney injury refractory to treatment. Whole body Flourine-18-fluorodeoxyglucose positron emission tomography computed tomography (18F-FDG PET/CT) showed increased metabolic uptake with ill-defined lesions in the liver, spleen, and pelvic lymph nodes. Biopsy of the ill-defined lesions in the liver showed necrotizing granulomatous lesions without angiitis. All the markers of tuberculosis were negative and angiotensin converting enzyme levels were elevated. Patient improved with 1 mg/kg/day oral steroid therapy and is on regular follow-up with minimal dose of steroids.
Conclusion:
Necrotizing sarcoid granulomatosis (NSG) is a rare systemic granulomatous disease. Due to its rarity and diagnostic difficulty, treatment is challenging for clinicians, pathologists and radiologists. Treatment of choice for symptomatic patients is steroid therapy. Prognosis is good with complete recovery.
Lane-Hamilton Syndrome in an Adult With Down Syndrome: A Case Report
Authors: Joana Fontes, Bárbara Sousa, Marta Moreira, Nuno Pardal, Rafael Lopes Freitas
Journal: Cureus (2023)
Keywords: celiac disease, down syndrome, idiopathic pulmonary hemosiderosis, lane-hamilton syndrome, young adult male
MeSH terms: Case Reports

The Lane-Hamilton syndrome (LHS) is an extremely rare association between celiac disease (CD) and idiopathic pulmonary hemosiderosis (IPH), with only a few cases reported in the literature. The authors report a case of a 32-year-old man with Down syndrome who presented to the emergency department with a history of hemoptysis and chronic diarrhea. The complementary investigation revealed iron deficiency anemia and features suggestive of diffuse alveolar hemorrhage on computed tomography (CT) scan of the chest. After excluding all competing diagnosis, the IPH diagnosis was made. The biopsy of the small intestine confirmed CD and the diagnosis of LHS was established. A gluten-free diet and steroids were given to the patient with a very good clinical response. Since there is an established association between IPH and CD, if the diagnosis of IPH is made, it's recommended to screen for CD even in patients without gastrointestinal symptoms.