OpenMed/multicare-articles huggingface dataset:
Intestinal Obstruction in a Patient with Sclerosing Encapsulating Peritonitis
Authors: Oday Obaid, Dawood Alhalabi, Mohamed Ghonami
Journal: Case Rep Surg (2017)
MeSH terms: Case Reports

Sclerosing encapsulating peritonitis (SEP) is a rare disorder that is characterized by encapsulation of bowel loops by thick fibrinogenous case. Most patients present with vague abdominal symptoms. It is challenging to diagnose the condition preoperatively. Surgical management is preserved for patients with small bowel obstruction with no improvement on conservative measures or for those with signs of bowel ischemia (Li et al., 2014; Habib et al. 2011). Herein, we discuss the clinical signs and symptoms, the radiological features, the surgical management, and outcome of SEP based on a patient who underwent surgery in our hospital.
Successful treatment of rituximab-unresponsive elderly-onset neuromyelitis optica spectrum disorder and hypogammaglobulinemia with ofatumumab plus intravenous immunoglobulin therapy in a patient with mutant FCGR3A genotype: A case report
Authors: Weihe Zhang, Yujuan Jiao, Jinsong Jiao, Ming Jin, Dantao Peng
Journal: Front Immunol (2022)
Keywords: case report, hypogammaglobulinemia, neuromyelitis optica spectrum disorder, ofatumumab, rituximab
MeSH terms: Agammaglobulinemia / drug therapy, Neuromyelitis Optica / drug therapy, Case Reports, Research Support, Non-U.S. Gov't, Aged, Female, Genotype, Humans, Immunoglobulins, Intravenous / therapeutic use, Immunologic Factors / therapeutic use, Immunosuppressive Agents / therapeutic use, Receptors, IgG, Recurrence, Rituximab / pharmacology, Rituximab / therapeutic use, Rituximab, Immunoglobulins, Intravenous, ofatumumab, Immunologic Factors, Immunosuppressive Agents, FCGR3A protein, human, Receptors, IgG

Background:
Elderly-onset neuromyelitis optica spectrum disorder (NMOSD) is a rare entity that poses a therapeutic challenge. We report a case of elderly-onset NMOSD with mutant FCGR3A genotype who was successfully treated with ofatumumab after multiple episodes of relapse.
Case report:
The patient was a 67-year-old woman who was diagnosed with NMOSD with high disease activity. She experienced six episodes of relapse over a period of 2 years despite immunosuppressant therapy with intravenous rituximab (RTX), oral steroids, mycophenolate mofetil, and tacrolimus. At the last relapse, she was unable to walk and developed immunosuppressant-induced hypogammaglobulinemia. Based on the insufficient B cell depletion and FCGR3A-FF genotype carrier, the patient was diagnosed as RTX non-responder. After subcutaneous ofatumumab plus intravenous immunoglobulin replacement therapy, she was able to walk independently, and experienced no further relapse. Ofatumumab was well-tolerated, and sufficiently depleted the circulating B cells.
Conclusion:
Ofatumumab might be an effective alternative in RTX-unresponsive NMOSD, and seems to be safe in elderly patients.
Case Report: Recombinant human growth hormone therapy in a patient with spondyloepiphyseal dysplasia, Kondo-Fu type
Authors: Congli Chen, Jin Wu, Ying Liu
Journal: Front Pediatr (2023)
Keywords: kondo-fu type, mbtps1, genotype, phenotype, rhgh therapy, spondyloepiphyseal dysplasia
MeSH terms: Case Reports

Background:
Variants in membrane-bound transcription factor peptidase, site 1 (MBTPS1) gene, can result in clinically rare spondyloepiphyseal dysplasia of Kondo-fu type (OMIM #618392, SEDKF), Silver-Russell syndrome, and CAOP (cataract, alopecia, oral mucosal disorder, and psoriasis-like) syndrome.
Case presentation:
A 6-year-old Chinese male child diagnosed with SEDKF underwent 3 years of growth hormone therapy. A genetic examination revealed two new nonsense variants in the MBTPS1 gene on chromosome 16q23-q24 with compound heterozygotes c.1589(exon12)A > G and c.163(exon2)G > A.
Conclusion:
The MBTPS1 gene c.1589(exon12)A > G and c.163(exon2)G > A on chromosome 16q23-q24 is associated with SEDKF. Growth hormone therapy can repair growth retardation in patients with spondyloepiphyseal dysplasia, Kondo-Fu type; however, more evidence of such patient cases is required to support this hypothesis.
Diffuse pulmonary meningotheliomatosis - a case report
Authors: S D Maasdorp, J-M Nel, M Prins
Journal: Afr J Thorac Crit Care Med (2020)
Keywords: meningothelial-like, meningotheliomatosis, miliary, pulmonary nodules
MeSH terms: Case Reports

Diffuse pulmonary meningotheliomatosis is a rare condition of the lung that presents with nonspecific respiratory symptoms, and usually follows a benign course. It should, however, be considered in the differential diagnosis of a miliary pattern on chest-imaging studies, as illustrated in the case reported.
Laparoscopic Resection of a Left Upper Quadrant Mass Leading to a Surprise Diagnosis
Authors: Hugo J R Bonatti, Reinhardt O Sahmel, Rodrigo B Erlich
Journal: Case Rep Surg (2020)
MeSH terms: Case Reports

Background. Resplenectomy is most commonly done for the treatment of recurrent idiopathic thrombocytopenic purpura (ITP) refractory to medical management due to the regrowth of a missed accessory spleen. Case Report. A 66-year-old male had undergone open splenectomy for traumatic rupture 40 years ago. He presented with a leiomyosarcoma of his leg, which was surgically removed. When he developed metastatic disease, chemotherapy was started. He developed left upper quadrant pain, and on CT scan, a 5 cm mass compatible with a sarcoma was found between the tail of the pancreas and the left adrenal gland. During laparoscopy, dense adhesion of the omentum to the abdominal wall and the stomach from his previous splenectomy was divided. The lesser sac was opened through the gastrocolic ligament, and the splenic flexure was taken down. Superior and dorsal to the tail of the pancreas next to the left adrenal gland, the mass was identified and carefully dissected out. The vascular pedicle, which originated from a side branch of the splenic vessels at the tail of the pancreas, was stapled. The gastric fundus showed multiple nodules, and therefore, a modified sleeve gastrectomy was done; also, a 2 cm nodule in segment 5 of the liver and an omental nodule were removed. The tumors and gastrectomy specimen were placed in an endobag and removed through a periumbilical mini-incision. The patient recovered without any complications from the procedure and his LUQ pain resolved. Pathology revealed no sarcoma metastases but accessory spleens in all specimens. Discussion. Splenosis with multiple implants within the abdomen after splenectomy for trauma is a rare condition. In our patient, this seems to have been triggered by chemotherapy for his sarcoma resulting in extramedullary hemopoiesis. Laparoscopic removal of accessory spleens can be safely done.
Intussusception in the Setting of an Ulcerative Colitis Flare
Authors: Varag Abed, Alexis Faber, Cristina Jageka, Ryan Goleniak, Raef Fadel
Journal: Case Rep Gastrointest Med (2022)
MeSH terms: Case Reports

Intussusception is an extraordinary cause of acute abdomen in adults and has been defined as the telescoping of a bowel segment into the lumen of an adjacent segment. A 43-year-old female presented to our hospital's emergency department (ED) with 10+ episodes of bloody diarrhea per day, left-sided abdominal pain, and the inability to tolerate oral intake for one month. She was initially diagnosed with ulcerative colitis (UC) ten years ago and is currently on mesalamine oral and enema therapy. She presented to our gastroenterology clinic two weeks after the beginning of her flare and was started on prednisone 40 mg daily. This did not improve her symptoms, and she presented to the ED two weeks later. She underwent a computed tomography (CT) abdomen/pelvis which revealed intussusception in the left hemiabdomen with no definite lead point measuring 5.6 cm in the craniocaudal dimension with pneumatosis and no evidence of bowel obstruction. There were no other significant laboratory abnormalities. Acute care surgery was consulted and suggested obtaining a CT enterography for further evaluation which showed spontaneous resolution of intussusception with no evidence of pneumatosis, portal venous gas, or intraperitoneal free air. She reports that following oral contrast intake, she "felt movement and relaxation" in her abdomen with substantial pain relief. Infectious workup was negative, and therapy was initiated with intravenous steroids. In conclusion, intussusception has been very rarely reported in patients with UC with the most common treatment being surgical resection. However, conservative management in the absence of bowel obstruction can be attempted.
A Glaucoma Patient with an Intraocular Pressure Decrease following Total Gastrectomy and Postoperative Anticancer Treatment
Authors: Yukihisa Takada, Takayoshi Sumioka, Tadahiko Tamura, Shizuya Saika
Journal: Case Rep Ophthalmol Med (2023)
MeSH terms: Case Reports

We herein report a case of glaucoma with an intraocular pressure (IOP) decrease following total gastrectomy (TG) and anticancer treatment for gastric cancer. A 62-year-old male underwent trabeculectomy of the left and right eyes in August 2011 and July 2012, respectively. During the follow-up, IOP of the right eye was 9-12 mmHg (with bimatoprost, dorzolamide, and timolol maleate), and that of the left eye ranged between 14 and 26 mmHg (with bimatoprost, dorzolamide, timolol maleate, and brimonidine tartrate). In December 2014, TG was performed due to gastric cancer. After surgery, the patient received S-1+CDDP, weekly PAC, and CPT-11 therapies. The patient died on March X, 2017. Before TG, the body mass index (BMI) was 29.5 but decreased to 24.8 before the start of the two courses of weekly PAC therapy. IOP of the right eye was 6 mmHg (with bimatoprost), and that of the left eye was 10 mmHg (with bimatoprost, dorzolamide, and brimonidine tartrate), showing decreases. After the initiation of weekly PAC therapy, BMI was approximately 19. IOP of the right eye ranged between 6 and 10 mmHg until the final ophthalmological examination (January 11, 2017), while that of the left eye ranged between 8 and 15 mmHg. In this patient with glaucoma, IOP was not controlled by eye drop treatment, and TG for gastric cancer and postoperative treatment with anticancer drugs resulted in weight loss and a decrease in IOP.
A Case of Traumatic Asphyxia due to Motorcycle Accident
Authors: Sedat Kamali, Sevgi Kesici, Ihsan Gunduz, Ugur Kesici
Journal: Case Rep Emerg Med (2013)

Background. Perthe's syndrome (traumatic asphyxia) is rare, which is caused by sudden compressive chest trauma and characterized by subconjunctival hemorrhage, facial edema, craniocervical cyanosis, and petechiae on the upper chest and face and should always be kept in mind as a possible complication of injuries of the chest and abdomen. Case Report. In this case report a 36-years-old male patient brought to the emergency room due to thorax trauma related to motorcycle accident was discussed. Distinct cyanotic, edematous, and multiple petechiae were present on the face, neck, and upper thorax regions of the patient. Bilateral subconjunctival hemorrhage was determined. Conclusion. Treatment for traumatic asphyxia is supportive and patient recovery is related to the generally associated injuries. Prognosis of the patients is quite good with effective and timely treatment.
Glomus Tumor: "A-Not-So-Rare" Cause of Chronic Shoulder Pain-A Case Report and Literature Review
Authors: Luís Vieira, Pedro Pereira, Bernardo Nunes, Rui Matos, António Sousa, Manuel Ribeiro da Silva
Journal: Case Rep Orthop (2021)
MeSH terms: Case Reports

Case:
A 61-year-old male presented with chronic shoulder pain resistant to conservative treatment. Imaging identified a nodular lesion in the deltoid muscle, which histology after resection identified as a glomus tumor. After surgery, the patient became asymptomatic and at 4-year follow-up has not shown signs of recurrence.
Conclusion:
Glomus tumors around the shoulder should be considered when investigating chronic shoulder pain, as they are more common than thought. Despite being elusive, when diagnosed, excellent outcomes may be expected, with surgery resection being curative.
Canine salivary gland carcinoma treated with stereotactic body radiation therapy: a retrospective case series
Authors: Patricia Gualtieri, Tiffany Martin, Del Leary, Susan E Lana, Susan M LaRue, Mary-Keara Boss
Journal: Front Vet Sci (2023)
Keywords: dog, lymph node, metastasis, neoplasia, radiotherapy

Objective:
The aim of this study was to describe the therapeutic outcomes of dogs with locally advanced salivary gland carcinomas (SGC) following stereotactic body radiation therapy (SBRT).
Methods:
A single institution retrospective study was conducted of client-owned dogs with macroscopic SGC treated with SBRT. Patient signalment, clinical characteristics, and treatment parameters were recorded. Clinical benefit was determined based on follow-up physical examination and medical history. Progression-free interval (PFI), median survival time (MST), and disease-specific survival (DSS) were calculated using Kaplan-Meier analysis. Acute and late toxicity were recorded according to Veterinary Radiation Therapy Oncology Group (VRTOG) criteria.
Results:
Six patients were included in the study. Tumor origins were mandibular (n = 3), parotid (n = 2), and zygomatic (n = 1) salivary glands. The SBRT prescription was 10 Gy × 3 daily or every other day. All patients (100%) experienced clinical benefit from treatment at a median time of 34 days (range 28-214). No local or regional nodal failure was reported following SBRT. Progressive pulmonary metastatic disease was documented in three dogs (50%). The median PFI was 260 days (range 43-1,014) and the MST was 397 days (range 185-1,014). Median DSS was 636 days (range 185-1,014). Four dogs (66.6%) died of confirmed or suspected metastatic SGC. The reported acute side effects included grade 2 mucositis (n = 1) and vision loss (n = 1). No late side effects were recorded.
Conclusion:
This study suggests that SBRT may provide durable local control for invasive SGC in dogs. Further investigation in a larger cohort of patients is warranted. The incidence of reported acute and late toxicity was low.
Severe Dental Disease as a Presenting Sign of Relapsed 6q24-Related Transient Neonatal Diabetes Mellitus
Authors: Anna Delamerced, Lauren J Massingham, Jose Bernardo Quintos
Journal: Case Rep Endocrinol (2020)
MeSH terms: Case Reports

Transient neonatal diabetes mellitus (TNDM) is a rare form of diabetes that presents in infancy and is characterized by intrauterine growth restriction and hyperglycemia without ketones on urinalysis. Patients are treated with insulin until remission, usually within the first year. Relapse to a permanent state may occur later in life, with a mean age of 14 years. The most common cause of TNDM is a chromosome 6q24 mutation that affects pancreatic β-cell function. Reports of relapse have been limited. We describe a case of an adolescent female with TNDM due to 6q24 hypomethylation who relapsed at 15 years of age with severe dental disease as the presenting sign.
Frequently Recurrent Takotsubo Syndrome in COPD
Authors: Juan Vaz, Rikard Berggren, Berne Eriksson
Journal: Case Rep Cardiol (2019)
MeSH terms: Case Reports

Cardiovascular disease is common among patients with chronic obstructive pulmonary disease (COPD). Takotsubo syndrome (TTS) is a transient cardiac disorder that, in its typical form, involves left ventricular dysfunction with apical ballooning and mimics acute coronary syndrome (ACS). "Bronchogenic TTS" has been proposed as a specific form of TTS (during severe acute dyspnea in asthma or COPD) with atypical presentation. Recurrent TTS in COPD seems to be exceptionally rare since only a handful of clinical cases have previously been reported in the literature. Here, we present a unique case of a frequently recurrent TTS during COPD exacerbation in a 70-year-old woman, with at least 4 different episodes of TTS within 5 years. This case report exemplifies the difficulties of the diagnosis of TTS at the onset of acute COPD exacerbation. Potential pathophysiological mechanisms and therapeutic strategies are also briefly discussed.
An unusual cause of right lower quadrant pain: the caecum diverticulitis
Authors: Murat Yildar, Omer Faruk Ozkan, Kasım Caglayan, Faruk Ozkul, Faruk Cavdar, Ismail Saygın
Journal: Case Rep Surg (2012)
MeSH terms: Case Reports

Purpose. In the study presented, preoperative examinations and surgical methods were discussed along with literature, regarding two cases who were operated with the prediagnosis of acute appendicitis and for whom caecum diverticulitis was determined. Case 1. 21 years old male patient who had applied to hospital with complaint of abdominal pain, underwent an operation with a prediagnosis of acute appendicitis. Right hemicolectomy was performed with mass perioperatively determined in caecum. Histopathological examination revealed necrosis and inflammation in diverticulum wall. Case 2. 36 years old female patient applied to emergency department with abdominal pain and underwent an operation with a prediagnosis of acute appendicitis. Appendectomy and diverticulectomy were performed for whom inflame diverticula in caecum was determined perioperatively. Histopathological examination was revealed acute inflammation in diverticulum wall. Conclusion. Although solitary caecum diverticulitis is a rarely encountered disease, it must be considered in the differential diagnosis of right lower abdomen pain.
Ileal neobladder adenocarcinoma occurring twenty-five years post ileocystoplasty: a case report
Authors: Mayank Agrawal, Gaurav Malvi, Nirmit Agrawal, Supradeep Narayanaswamy, Rajvi Goradia, Bhushan Patil, Sujata Patwardhan
Journal: Pan Afr Med J (2023)
Keywords: augmentation cystoplasty, adenocarcinoma, case report
MeSH terms: Adenocarcinoma / diagnosis, Adenocarcinoma / etiology, Adenocarcinoma / surgery, Duodenal Neoplasms / pathology, Urinary Bladder Diseases / pathology, Urinary Bladder Neoplasms / diagnosis, Urinary Bladder Neoplasms / surgery, Case Reports, Adult, Female, Humans, Ileum / pathology, Ileum / surgery, Urinary Bladder / pathology, Urinary Bladder / surgery, Urologic Surgical Procedures / adverse effects

De-tubularised ileum is one of the most common segments used for augmentation cystoplasty. It is associated with complications such as metabolic disturbances, recurrent urinary tract infections, and stone formation. However, adenocarcinoma arising in an augmented bladder is a rare occurrence. We report a 37-year-old female, case of ileocystoplasty 25 years ago due to a thimble bladder (genitourinary tuberculosis) who presented with hematuria for one month. Cystoscopy showed bladder mass in the transposed ileal segments. The patient underwent transurethral resection of the bladder lesion, and the histopathology was suggestive of adenocarcinoma of the ileum. Subsequently, she underwent anterior pelvic exenteration and post-operative recovery was uneventful. The 6-month follow-up showed that the patient was asymptomatic without recurrence. In conclusion, even though adenocarcinoma in the ileal neobladder is rare, life-long with close follow-up with routine cytologic, radiologic, and cystoscopic evaluation for early cancer detection and treatment at an early stage is crucial.
Pneumoperitoneum in a Micropremie: Not Always NEC
Authors: Ahmed Khan, Koert de Waal
Journal: Case Rep Pediatr (2012)
MeSH terms: Case Reports

Pneumoperitoneum in the newborn is an acute surgical emergency requiring immediate surgical intervention to ensure survival. It refers to radiological evidence of rupture of an air-containing viscus with resultant soiling of the peritoneal cavity. A female baby was born preterm at 29 weeks with birth weight of 650 grams. She developed abdominal distension on day 6, and abdominal radiography revealed presence of free air in the peritoneum. She proceeded for a laparotomy, and intraoperative findings revealed blood in the peritoneum with an area of inflammation and a small perforation. About 5 cm of the inflamed bowel was resected, and an end to end anastomosis performed. The histopathology of the specimen was consistent with Meckel's diverticulum. Symptomatic Meckel's diverticulum is usually seen in the first two years of life, and perforation is a rare presentation. Perforated Meckel's diverticulum in a premature newborn is very rare, and a review of literature reveals only one other reported case. Newborn Meckel's perforation cases often mimic necrotizing enterocolitis, although many present without any feature of peritonitis. Establishing a preoperative diagnosis of perforated Meckel's is difficult and may not be essential as the treatment remains the same. However, prompt surgical intervention confers a good prognosis in neonates with isolated perforated Meckel's diverticulum.
Isolated Superior Oblique Muscle Swelling Causing Acute Vertical Strabismus in Graves' Disease
Authors: Keiichi Aomatsu, Shunji Kusaka
Journal: Case Rep Ophthalmol Med (2020)
MeSH terms: Case Reports

Purpose:
To report a case of isolated superior oblique muscle swelling causing acute vertical strabismus in Graves' disease.
Case:
A 26-year-old woman with a 1-month history of misalignment of the right eye and diplopia was referred to us. Her visual acuity and intraocular pressures were normal in both eyes, but eye movement tests showed clear misalignment of her right eye. Antibody tests for myasthenia gravis were negative. However, blood tests revealed abnormal levels of thyroid-related factors, such as decreased thyroid-stimulating hormone, elevated free T3 and T4, and elevated anti-thyroid-stimulating hormone receptor antibody. We performed magnetic resonance imaging (MRI), which showed slight enlargement of the left superior oblique muscle. The patient was eventually diagnosed with Graves' disease with superior oblique muscle involvement and underwent a thyroidectomy. Three months postoperatively, her diplopia and abnormal eye movements had substantially resolved.
Conclusion:
Isolated superior oblique muscle involvement may be a presenting symptom of Graves' disease. It should be taken into consideration that, in the early stages of thyroid-associated ophthalmopathy (TAO) in adults, only the superior oblique muscle may be enlarged.