OpenMed/multicare-articles huggingface dataset:
A Case Report of a Baby Born to a Woman With Isolated Right Ventricular Apical Hypoplasia Without an Atrial Septal Defect
Authors: Hiroaki Kawano, Yutaro Seo, Hiroki Usuku, Fumi Oike, Megumi Nakata, Shota Nakamura, Michiko Sugita, Kenichi Tsujita
Journal: Cureus (2024)
Keywords: adult congenital heart disease, giant right atrium, hypoplastic right ventricle, pregnancy and heart disease, right heart failure
MeSH terms: Case Reports

Pregnancy is a major life event for most women that causes extensive physiological changes. Hence, it is associated with additional risks in women with congenital heart disease. No reports of pregnancy or a baby born to a woman with isolated right ventricular hypoplasia without an atrial septal defect have been published. In this case, the patient's right ventricle was very small with no contractility. The right atrium was highly enlarged, and its contractility resulted in pulmonary circulation without pulmonary hypertension. The size increased post-delivery than that before pregnancy. Fortunately, a healthy infant was born without any right heart failure symptoms.
Multi-disciplinary management of recurrent gastrointestinal stromal tumor harboring KIT exon 11 mutation with the switch-control kinase inhibitor ripretinib and surgery
Authors: Mohamed A Gouda, Filip Janku, Neeta Somaiah, Kelly K Hunt, Sireesha Yedururi, Vivek Subbiah
Journal: Oncoscience (2023)
Keywords: precision oncology, ripretinib, sarcoma, surgery
MeSH terms: Case Reports

Ripretinib is a tyrosine kinase inhibitor that was approved by the United States FDA in 2020 for treatment of advanced gastrointestinal stromal tumor (GIST) in patients who received prior treatment with three or more tyrosine kinase inhibitors. In this case report, we show the durable clinical benefit achieved in a patient with GIST by using ripretinib and repeated timely surgical resection of limited disease progression. The total time on ripretinib was 43 months which is longer than the current reported data from ripretinib clinical trials. Such approach for using multi-disciplinary disease management can improve the durability of response to tyrosine kinase inhibitors, including ripretinib, and associated clinical outcomes.
Central Pancreatectomy: Balancing between the Favorable Functional Results and the Increased Associated Morbidity
Authors: Dimitrios Symeonidis, Ismini Paraskeva, Athina A Samara, Labrini Kissa, Alexandros Valaroutsos, Eleana Petsa, Konstantinos Tepetes
Journal: Surg J (N Y) (2024)
Keywords: central pancreatectomy, functional results, morbidity, postoperative pancreatic fistula
MeSH terms: Case Reports

Introduction Central pancreatectomy (CP) represents an organ-preserving type of pancreatic resection. The procedure has been associated with improved long-term functional results, but increased postoperative morbidity rates, compared with the more radical resection types. The purpose of the present study was to present the outcomes of three consecutive CPs performed in our department. Materials and Methods Between January 2021 and January 2022, three patients (A, B, and C) were submitted to a CP in our department. Relevant patient data including data of the detailed preoperative assessment, operations notes, and recovery charts were prospectively collected and reviewed for all subjects. A scheduled follow-up, at the outpatient clinic, was conducted to assess the long-term functional results. Results The postoperative course of patient A, a 56-year-old male, was complicated by a grade C postoperative pancreatic fistula that required a reoperation. Patient B, a 66-year-old female, developed a biochemical leak that resolved spontaneously while patient C, a 64-year-old male, had a completely uneventful recovery. The length of hospital stay for the three patients was 24, 12, and 8 days, respectively. Regarding the long-term results, patient B was lost to follow-up while both patient A and C were followed up, as outpatients, 21 and 10 months after the operation. During follow-up, in patient A, we did not record the presence of symptoms consistent with pancreatic exocrine insufficiency, the hemoglobin A1C (HbA1C) levels were 7.1% while no additional medications were needed to be prescribed to maintain the glycemic control following surgery. In patient C, a significant weight loss was recorded (body mass index reduction of 11 kg/m 2 ) without however the presence of malabsorption-specific symptoms. The HbA1C levels were 7.7% and optimal glycemic control was achieved with oral antiglycemic agents alone. Conclusion CP should be regarded as a type of pancreatic resection with certain and very limited oncological indications. An approach of balancing the advantages out of the superior postoperative functional results with the drawbacks of the increased procedure-associated morbidity could highlight the patient group that could potentially experience benefits out of this limited type of resection.
Unexpected "Lazarus response" to single-agent bevacizumab in heavily pretreated patients with HER2-positive breast cancer
Authors: Alexey V Emshanov, Denis V Nesterov, Tatyana N Sokolova, Priscilla S Amankwah, Evgeny N Imyanitov
Journal: Explor Target Antitumor Ther (2023)
Keywords: bevacizumab, her2, breast cancer, edema, single-agent therapy
MeSH terms: Case Reports

Early clinical trials aimed to halt cancer progression by inhibiting the growth of new blood vessels in tumors through single-agent targeted therapy with bevacizumab. These trials largely proved unsuccessful. However, bevacizumab turned out to be efficient when administered in combination with other anticancer drugs. The efficacy of this approach is explained by the ability of bevacizumab to eliminate immature blood vessels thus normalizing intratumoral blood flow and improving the delivery of cytotoxic or targeted agents. This report describes four cases of heavily pretreated patients with metastatic HER2-positive breast cancer, who had no meaningful treatment options left, and who received single-agent bevacizumab as an empirical last-resort therapy. Three of these patients had severe complaints, and they demonstrated striking symptomatic relief within the first day of this treatment. In addition to the observed "Lazarus response", which was likely attributed to the bevacizumab-driven resolution of edema, some evidence of a direct antitumor effect was observed. These data may call for the reconsideration of bevacizumab monotherapy in patients with HER2-associated breast cancer, and perhaps in some other categories of cancer patients.
Gingival cyst of the adult
Authors: Maria Emília Mota, Dandara Menezes de Araujo Oliveira, Yuri de Lima Medeiros, Maria Stella Moreira, Rodrigo Nascimento Lopes, Fábio Abreu Alves, Brendo Vinícius Rodrigues Louredo, Pablo Agustin Vargas, José Divaldo Prado
Journal: Autops Case Rep (2023)
Keywords: cysts, gingival diseases, odontogenic cysts
MeSH terms: Case Reports

The gingival cyst of the adult (GCA) is a rare odontogenic cyst, consisting of 0.3% of all odontogenic cysts. This case report, based on CARE guidelines for case reports, aims to present a case of a 52-year-old female patient with a symptomatic translucent nodule in the upper left anterior gingiva, measuring approximately 6mm. Excisional biopsy was performed, and the histological examination revealed multiple cystic cavities lined by the squamous epithelium of varying thickness with focal areas of nodular thickenings. The presence of clusters of cells with clear cytoplasm within epithelial thickenings was observed. PAS staining was negative in clear cells. The diagnosis of the GCA was established. Despite its rarity, GCA should be considered in the differential diagnosis of gingival lesions. Conservative surgical treatment proved to be effective, with no signs of recurrence.
MRI of Paraspinal Gossypiboma: Look for the Barium Sulfate Filament
Authors: Julian Kent Seghers, Tom Oyen, Jan Erik Vandevenne
Journal: J Belg Soc Radiol (2023)
Keywords: barium sulphate, gossypiboma, mri, textiloma, wire
MeSH terms: Case Reports

Gossypiboma is a rare post-surgical complication comprising a retained surgical gauze surrounded by a foreign body reaction. Although usually presenting on magnetic resonance imaging (MRI) with low T1 signal, high central and low peripheral signal on T2, and bandlike peripheral enhancement, MR appearance is often non-specific. The barium sulphate filament within a surgical gauze presents on MR as a curvilinear thread which is dark on both T1 and T2 sequences. Scrutinizing the MR images is critical to identify the filament and to pinpoint the diagnosis of gossypiboma. Teaching Point: A paraspinal mass on postoperative spine MRI should be carefully searched for a hypointense contorted wire (the barium sulfate filament), as it may be the characteristic finding to evocate the diagnosis of gossypiboma.
Horizontal Pendular Nystagmus and Ataxia Secondary to Severe Hypomagnesemia
Authors: Marcos Polanco, María Rivera, Leire Manrique, Carmen Lage, Jon Infante
Journal: Tremor Other Hyperkinet Mov (N Y) (2024)
Keywords: pendular nystagmus, ataxia, cerebellum, hypomagnesemia
MeSH terms: Cerebellar Ataxia / complications, Cerebellar Ataxia / physiopathology, Nystagmus, Pathologic / etiology, Nystagmus, Pathologic / physiopathology, Case Reports, Video-Audio Media, Female, Humans, Magnesium Deficiency / complications, Male, Middle Aged

Background:
Severe hypomagnesemia is an increasingly recognized cause of acute and reversible cerebellar ataxia, often accompanied by cerebellar oculomotor signs such as jerky horizontal or downbeat nystagmus and very rarely ocular flutter.
Phenomenology shown:
This video illustrates horizontal pendular nystagmus in a patient with acute onset cerebellar ataxia associated with severe hypomagnesemia.
Educational value:
Acquired pendular nystagmus can be distinguished from macrosaccadic oscillations and ocular flutter in that the former is composed of two slow phases of equal velocity and the latter of two fast phases of saccadic type with or without intersaccadic interval, respectively. It is most commonly associated with demyelinating, toxic, metabolic, and genetic disorders, but has not been reported in association with severe hypomagnesemia.
Endoscopic Resection of a Cavernous Hemangioma in the Sigmoid Colon: A Case Report
Authors: Noora Al-Khater, Mohamed Mohamed, Afra Juma, Faisal Abubaker, Sameer Ansari
Journal: Gastro Hep Adv (2023)
Keywords: abdominal pain, endoscopy, hemangioma, sigmoid colon
MeSH terms: Case Reports

Hemangiomas in the gastrointestinal tract are extremely rare, benign vascular tumors, known for their associated complication of bleeding. They are usually difficult to diagnose, despite the characteristic definition of radiolucent phleboliths on radiology and purplish, tannish brown nodule or polyp on endoscopy. Surgical resection is the treatment of choice. We describe a rare case of sigmoid colon cavernous hemangioma in a 49-year-old male who underwent colonoscopy for lower abdominal pain and revealed a large pedunculated polyp in the sigmoid colon measuring 1.7 cm in diameter. The hemangioma was completely resected endoscopically via hot snare with a favorable outcome.
Vital Pulp Therapy in Permanent Teeth Diagnosed with Symptomatic Irreversible Pulpitis: Reports with Long-Term Controls
Authors: Abel Teves-Cordova, Luis Coloma Calle, Pierre Mejia Rojas, Juan Goncalves-Pereira, Marco Antonio Hungaro Duarte
Journal: Case Rep Dent (2023)
MeSH terms: Case Reports

The aim of this study was to describe the treatment of permanent teeth diagnosed with irreversible pulpitis, which can be effectively managed with partial or total pulpotomy. This alternative approach has shown great clinical and radiographic success in the long term compared to traditional pulpectomies. In this series of clinical cases, all the teeth exhibited symptoms of intense pain upon exposure to cold and at night. The clinical examination revealed extensive caries, while radiographic imaging showed radiolucent lesions in contact with the pulp chamber, indicating symptomatic irreversible pulpitis. The chosen treatment approach was either partial or total pulpotomy. The tooth was anesthetized, and the operative field was isolated and disinfected. After removing caries with a sterile round drill, the area was rinsed with sodium hypochlorite. In some cases, a portion of the pulp tissue was removed, while in others, the entire tissue of the pulp chamber was extracted using diamond burs. Hemostasis was achieved by applying sterile cotton pellets for 2 to 6 minutes. Following that, the tissue exhibited no signs of bleeding. Bioceramic cements were used, and the tooth was definitively restored. Periodic follow-up examinations were conducted, consistently showing positive pulp responses and no evidence of periradicular radiolucent lesions on radiographs.
Type II Crigler-Najjar syndrome: a case report and literature review
Authors: Tao He, Xiaoling Geng, Lei Zhu, Xue Lin, Lixia Wang
Journal: Front Med (Lausanne) (2024)
Keywords: crigler-najjar syndrome, ugt1a1, case report, hyperbilirubinemia, phenobarbital
MeSH terms: Case Reports

Background:
Crigler-Najjar syndrome (CNS) is caused by mutations in uridine 5'-diphosphate glucuronyltransferase (UGT1A1) resulting in enzyme deficiency and hyperbilirubinemia. Type II CNS patients could respond to phenobarbital treatment and survive. This study presents a rare case of type II CNS.
Case summary:
The proband was a 29-year-old male patient admitted with severe jaundice. A hepatic biopsy showed bullous steatosis of the peri-central veins of the hepatic lobule, sediment of bile pigment, and mild periportal inflammation with normal liver plate structure. The type II CNS was diagnosed by routine genomic sequencing which found that the proband with the Gry71Arg/Tyr486Asp compound heterozygous mutations in the UGT1A1 gene. After treatment with phenobarbital (180 mg/day), his bilirubin levels fluctuated between 100 and 200 μmol/L for 6 months and without severe icterus.
Conclusion:
Type II CNS could be diagnosed by routine gene sequencing and treated by phenobarbital.
Case Report: Atypical presentation of non-functional gonadotropinoma
Authors: Suresh Oommen, Sam Rice
Journal: F1000Res (2023)
Keywords: non-functional pituitary adenoma, gonadotropinoma, hemianopia
MeSH terms: Pituitary Neoplasms / diagnostic imaging, Pituitary Neoplasms / surgery, Case Reports, Humans, Middle Aged, Postoperative Period

Gonadotropinoma is the most common non-functional pituitary adenoma comprising 10%-30% of all pituitary adenomas. They are benign slow-growing tumours originating from adenohypophysis and rarely become malignant. Its presentation can be atypical, such as visual disturbance, and most patients presenting to an ophthalmologist for visual correction are eventually found to have a field defect. Here, we report a case of a 59-year-old patient who presented with a left-sided visual disturbance, which progressed over the years due to a left temporal hemianopia. The patient was referred to us by an ophthalmologist and was diagnosed with a giant non-functional gonadotropinoma. The patient was surgically treated. Postoperative follow-up magnetic resonance imaging after 3 months showed near complete resection of the tumour.
Severe, very early onset preeclampsia in a Covid 19-positive woman with a twin pregnancy presenting with a hydatidiform mole and coexisting normal fetus: a case report
Authors: Daniela Willy, Ralf Schmitz, Mareike Möllers, Barbara Heitplatz, Anna Kuntze, Yvonne Stratis, Katrin Bahlke, Albrecht Röpke, Matthias Meyer-Wittkopf, Kathrin Oelmeier
Journal: Front Med (Lausanne) (2024)
Keywords: case report, complete mole, gestational trophoblastic disease, hydatidiform mole, preeclampsia
MeSH terms: Case Reports

Cases of hydatidiform moles with a coexisting fetus are sparse and patients are at high risk for severe complications. Patients and physicians often face the dilemma of the wish to continue pregnancy until viability of the fetus while the risk for maternal complications increases. We present an educational case of a twin pregnancy presenting with a hydatidiform mole and coexisting normal fetus with a placenta praevia. The patient developed severe, early onset preeclampsia with beginning HELLP-syndrome and was tested Covid-19 positive in the further course. Termination of pregnancy was conducted via caesarean section at 18 + 6 weeks of pregnancy. Histopathology and genetic analysis confirmed a complete hydatidiform mole next to a normal placenta. Close follow-up examinations were conducted and showed normal findings including ß HCG levels normalizing within 5 months. This case combines several rare, difficult and severe medical conditions and demonstrates how an individualized therapy by an interdisciplinary team covering a highly sensitive topic was developed in a situation where no guidelines exist.
Case report: Transmural migration of a gossypiboma with secondary cystolithiasis and urethral obstruction
Authors: Meghan L Lancaster, Chad W Schmiedt
Journal: Front Vet Sci (2024)
Keywords: canine, cystolithiasis, gossypiboma, surgical gauze, textiloma, transmural migration, urinary obstruction
MeSH terms: Case Reports

This report describes a case of transmural migration of a gossypiboma from the peritoneum into the urinary bladder in a 4-year-old, female spayed, mixed-breed dog. The dog was presented on an emergency basis for complete urethral obstruction with radiographic evidence of urocystolithiasis. An exploratory laparotomy was performed and a 4-5 cm mass was identified which was confluent with the apex of the urinary bladder. The mass and bladder were exteriorized and isolated, and an apical, partial cystectomy was performed to remove the mass and gain access to the uroliths within the lumen of the bladder. A 4×4 surgical sponge was identified within the trigone of the bladder, it had multiple uroliths; another sponge was also found within the mass itself. This case demonstrates an atypical cause of urethral obstruction and serves as the first reported case of transmural migration of a gossypiboma into the urinary bladder of a dog. It also illustrates the importance of establishing routine operating procedures including gauze counts and the use of radiopaque-labeled surgical gauze.
A case report and a literature review of double mammary pseudoangiomatous stromal hyperplasia associated with galactoma during pregnancy
Authors: Minmin Yu, Guangxi Shi, Zong Gao, Kai Wu, Cuilei Wei, Xiaohong Li, Xiuming Miao
Journal: Front Oncol (2024)
Keywords: breast, mammary gland, pregnancy period, pseudoangiomatous stromal hyperplasia, tumor
MeSH terms: Case Reports

Pseudoangiomatous stromal hyperplasia (PASH) is a benign interstitial hyperplasia of the breast that usually occurs in premenopausal or perimenopausal women. It is usually characterized by localized lesions or clear boundary masses, and diffuse double breast enlargement is rare. PASH is considered a hormone-dependent disease that is commonly progesterone related. There are no imaging characteristics, and both benign and suspicious malignant signs can be seen. The definitive diagnosis of PASH depends on a pathological diagnosis, and it is necessary to be vigilant in distinguishing between benign and malignant tumors with similar breast histopathology. Here, we report the case of a 23-year-old multipara patient with bilateral diffuse pseudoangiomatous stromal hyperplasia of the breast during pregnancy who presented with macromastia and reviewed the literature to further understand the clinical features, pathological diagnosis, differential diagnosis, treatment and prognosis of pseudoangiomatous stromal hyperplasia of the breast.
Giacomini's vein - a report on the invaluable importance of an anomalous short saphenous vein
Authors: Abdalla Ahmed Eldaw Elamin, Naveen Kumar, Vijay Paul Samuel, Kumar Megur Ramakrishna Bhat
Journal: J Vasc Bras (2024)
Keywords: giacomini’s vein, ssv, sural artery flap, varicose vein
MeSH terms: Case Reports

Variations in the drainage (termination) and course of the lower limb veins are not uncommon. When dissecting the left lower limb of the adult male cadaver in the vascular case described herein, a unique kind of unilateral short saphenous vein (SSV) termination was observed. It was found that the SSV had normal origin and course in the dorsum of the foot and the back of the leg, respectively. Most often the SSV terminates in the popliteal vein at the popliteal fossa. In this case, it extended upward into the back of the thigh, passing behind the sciatic nerve and then deep to it and the biceps femoris, and finally ended in the veins of the thigh. The SSV did not penetrate any structures along its course to the end, so this unusual vein appears unlikely to be associated with SSV varicose veins. For general, plastic, cardiothoracic, and vascular surgeons, our case would be of significant value.
Concomitant Cytomegalovirus Viraemia in Multisystem Inflammatory Syndrome in Adults (MIS-A) following COVID-19
Authors: Benjamin Valente-Acosta, Francisco Moreno-Sánchez, Yvette Neme-Yunes, Sara López-Rueda, Irma Hoyo-Ulloa, Mónica Garcia-Gutierrez
Journal: Case Rep Infect Dis (2024)
MeSH terms: Case Reports

Multisystem inflammatory syndrome in adults (MIS-A) is recognised as an infrequent complication of coronavirus disease 2019 (COVID-19). This syndrome occurs following COVID-19 infection in some individuals and is characterised by inflammation of multiple organ systems, such as the heart, liver, bowel, and lymph nodes. Cytomegalovirus (CMV) viraemia is associated primarily with immunosuppression. In COVID-19 patients, it has been reported in severe and critical cases. We present a case of an adult patient diagnosed with MIS-A and concomitant CMV viraemia.
A Man in His Forties with Recurrent Cat-Scratch Disease
Authors: Sara López-Rueda, Benjamin Valente-Acosta, Adrian Murillo-Zolezzi, Francisco Moreno-Sánchez, Irma Hoyo-Ulloa, Jesús Javier Baquera-Heredia
Journal: Case Rep Infect Dis (2024)
MeSH terms: Case Reports

Cat-scratch disease (CSD) is a self-limited zoonotic infection transmitted by felines caused by the Gram-negative bacillus Bartonella henselae. It usually presents with lymphadenopathy and constitutional symptoms that resolve within eight weeks, with, or without antibiotic treatment. The diagnosis is made by serology, molecular diagnosis in a biopsy, or a positive culture. The recurrence or reactivation of B. henselae has rarely been reported. We present the case of a 45-year-old man with a history of CSD two years before who presented to the clinic with groin lymphadenopathy. The patient had a history of close contact with felines though no known risk exposure was reported. The diagnosis was made with a positive serology suggestive of recent infection along with histopathological changes suggestive of CSD. Subsequently, azithromycin was administered with complete resolution of symptoms.