OpenMed/multicare-articles huggingface dataset:
Impaction Of Rehabilitations And Strengthening Programs before And after Anterior Cruciate Ligament Reconstruction In Return to the Fitness Level
Authors: Abdulwahab Ahmed Alzahrani
Journal: J Environ Public Health (2022)
MeSH terms: Anterior Cruciate Ligament Injuries / etiology, Anterior Cruciate Ligament Injuries / surgery, Anterior Cruciate Ligament Reconstruction / adverse effects, Anterior Cruciate Ligament Reconstruction / rehabilitation, Retracted Publication, Exercise, Follow-Up Studies, Humans, Retrospective Studies, Treatment Outcome

Objectives:
Sports injuries are one of the most common orthopedic injuries particularly in young and active populations. Football is the most popular sport among Saudis, and thus, anterior cruciate ligament (ACL) injuries are common in clinics and emergency rooms in Saudi Arabia. The aim of this study was to evaluate the outcomes of patients six months after ACL reconstruction in both hospitals and gym-based rehabilitation services and its impaction on the patients to return to sports and preinjury fitness levels.
Methods:
This is a retrospective case series of patients who underwent arthroscopically assisted ACL reconstruction using a hamstring autograft at our center. Data were gathered from January 2020 to December 2020. Patients were given a questionnaire about their visits to the orthopedic clinic in the 6th month after surgery.
Results:
Sixty patients with ACL reconstructions were studied. Noncontact sports were the leading cause of injuries (53.3%). The mean Lysholm score was 84.9 (SD 3.45) out of 100 after six months of follow-up, and the mean Tegner score was 4.77 (SD 1.06) out of 10 points. The Lysholm score was excellent (>90) among 5% (n= 3), good (84-90) among 60% (n= 36), and fair (65-83) among 35% (n= 21). As a result, we observed that the duration of postoperative rehabilitation has a significant relationship with the fitness level (X2= 18.711; p=0.001).
Conclusion:
The Lysholm knee scoring scale and the Tegner activity scale showed that arthroscopically assisted ACL reconstruction using hamstring autograft has a successful and functional outcome after which the patient returns to sports or regains the preinjury level of fitness level depends on the rehabilitation.The period and types of preoperative and postoperative rehabilitation have a direct impact on the return to fitness levels and normal daily life activities.
Incidental Ureteroinguinal Hernia in a Patient With a Single Kidney
Authors: Ana Costa, Joana Granadas, Marta Baptista
Journal: J Belg Soc Radiol (2022)
Keywords: hernia, inguinal, ureter
MeSH terms: Case Reports

Teaching point: An ureteroinguinal hernia is a very rare diagnosis with typical radiological findings that must be reported, particularly in surgical candidates.
Helical irradiation of the total skin with dose painting to replace total skin electron beam therapy for therapy-refractory cutaneous CD4+ T-cell lymphoma
Authors: Chen-Hsi Hsieh, Pei-Wei Shueng, Shih-Chiang Lin, Hui-Ju Tien, An-Cheng Shiau, Yueh-Hung Chou, Meng-Hao Wu, Jen-Yu Wang, Chi-Kuan Chen, Yu-Jen Chen
Journal: Biomed Res Int (2013)
MeSH terms: CD4-Positive T-Lymphocytes, Lymphoma, T-Cell, Cutaneous / radiotherapy, Radiotherapy, Image-Guided, Radiotherapy, Intensity-Modulated, Skin Neoplasms / radiotherapy, Case Reports, Research Support, Non-U.S. Gov't, Adult, Female, Humans, Lymphoma, T-Cell, Cutaneous / pathology, Skin Neoplasms / pathology

A 36-year-old woman was diagnosed with a therapy-refractory cutaneous CD4+ T-cell lymphoma, T3N0M0B0, and stage IIB. Helical irradiation of the total skin (HITS) and dose painting techniques, with 30 Gy in 40 fractions interrupted at 20 fractions with one week resting, 4 times per week were prescribed. The diving suit was dressed whole body to increase the superficial dose and using central core complete block (CCCB) technique for reducing the internal organ dose. The mean doses of critical organs of head, chest, and abdomen were 2.1 to 29.9 Gy, 2.9 to 8.1 Gy, and 3.6 to 15.7 Gy, respectively. The mean dose of lesions was 84.0 cGy. The dosage of left side pretreated area was decreased 57%. The tumor regressed progressively without further noduloplaques. During the HITS procedure, most toxicity was grade I except leukocytopenia with grade 3. No epitheliolysis, phlyctenules, tumor lysis syndrome, fever, vomiting, dyspnea, edema of the extremities, or diarrhea occurred during the treatment. HITS with dose painting techniques provides precise dosage delivery with impressive results, sparing critical organs, and offering limited transient and chronic sequelae for previously locally irradiated, therapy-refractory cutaneous T-cell lymphoma.
Desmosis coli - a case report and review of the literature
Authors: Jayesh Desale, Hemanshi Shah, Vikrant Kumbhar, Gursev Sandlas
Journal: Dev Period Med (2017)
Keywords: children, constipation, desmosis coli
MeSH terms: Colon / pathology, Colonic Diseases / pathology, Connective Tissue Diseases / pathology, Constipation / etiology, Case Reports, Review, Colon / diagnostic imaging, Colonic Diseases / diagnostic imaging, Colonic Diseases / surgery, Connective Tissue / pathology, Connective Tissue Diseases / diagnostic imaging, Connective Tissue Diseases / surgery, Dilatation, Pathologic, Female, Humans, Infant

Desmosis coli is a rare pathology presenting as slow transit constipation. In this case we would like to discuss the presentation and management of desmosis coli. A 14-month-old female hailing from western India with a history of chronic constipation presented with acute massive abdominal distension and vomiting. At laparotomy, a hugely dilated transverse and sigmoid colon with a transition zone at the lower sigmoid was found. A transverse stoma was done after taking multiple sero-muscular biopsies. The patient underwent re-exploration on day 14 because of the non-functioning of the stoma and a fixed bowel loop. The histopathology report was suggestive of normal ganglion cells. Unfortunately, the stoma continued not to function. A dye study showed dye in the colon after 24 hours ruling out any anatomical obstruction. Histopathology slides were reviewed multiple times and reported lack of connective tissue of the colonic wall leading to the diagnosis of desmosis coli. The patient was started on gradual feeds and pro-kinetics and over the next 2 weeks the stoma started functioning slowly. Desmosis coli is a rare cause of constipation which should be suspected in cases where aganglionosis has been ruled out and the constipation is refractory to conventional therapy.
Next-Generation Sequencing Reveals Novel Homozygous Missense Variant c.934T > C in POLR1C Gene Causing Leukodystrophy and Hypomyelinating Disease
Authors: Muhammad Imran Naseer, Angham Abdulrahman Abdulkareem, Peter Natesan Pushparaj, Samah Saharti, Osama Y Muthaffar
Journal: Front Pediatr (2022)
Keywords: polr1c, saudi family, wes, hypomyelinating disease, intellectual developmental disorder, leukodystrophy
MeSH terms: Case Reports

Leukodystrophies are a diverse group of genetically established disorders categorized by unusual white matter changes on brain imaging. Hypomyelinating leukodystrophies (HLDs) are a group of neurodevelopmental disorders that affect myelin sheath development in the brain. These disorders are categorized as developmental delay, spasticity, hypotonia, and intellectual disabilities. We describe a patient with developmental delay, cerebellar ataxia, spasticity, hypotonia, and intellectual disability from a healthy family member. Whole exome sequencing (WES) was performed to identify causative variants, which were further analyzed by bioinformatic analysis. WES was performed, and Sanger sequencing-based segregation analysis confirmed the presence of the homozygous missense variants of NM_203290.3 c.934T > C p.Ser312Pro of RNA polymerase I and III subunit C (POLR1C) gene in this patient and heterozygous variant in the unaffected carrier father and mother, supporting the pathogenicity and inheritance pattern of this variant. Furthermore, the variant identified by WES was validated in healthy controls (n = 100) using Sanger sequencing analysis. Finally, our study explained the important use of WES in disease diagnosis and provided further evidence that the variant in the POLR1C gene may play an important role in the development of hypomyelinating leukodystrophy in Saudi families.
Staphylococcus aureus Infections in the Paediatric Intensive Care Unit: Illustrated Cases
Authors: Kam Lun Hon, Ronald C M Fung, Karen K Y Leung, Alexander K C Leung, Wun Fung Hui, Wing Lum Cheung
Journal: Case Rep Pediatr (2021)
MeSH terms: Case Reports

Staphylococcus aureus is known to be one of the most common gram-positive microorganisms and an important pathogen associated with sepsis and toxic shock. We present four anonymized consecutive cases in a paediatric intensive care unit (PICU) to illustrate the different clinical manifestations of staphylococcal infections, including local infection versus systemic infection, toxic shock versus septic shock, and osteomyelitis. Eczema, short gut syndrome, and scald injury may be associated. Haematologic and coagulopathic abnormalities may be present. Prompt diagnosis and use of appropriate antimicrobial treatments is essential to reducing mortality and morbidity associated with staphylococcal infections.
Intraoperative Capnothorax during Robotic Diaphragmatic Endometriosis Excision
Authors: Tyler Dunn, Lopa Misra
Journal: Case Rep Anesthesiol (2022)
MeSH terms: Case Reports

Laparoscopic surgery is performed quite commonly and is known to have numerous advantages over traditional open surgery. Albeit rare, there are life-threatening complications as a result of laparoscopic surgery including those associated with the cardiopulmonary system. In our case, we present hemodynamically unstable capnothorax that occurred during robotic diaphragmatic endometriosis excision which was treated conservatively. It is critical for anesthesia providers to recognize when capnothorax occurs and to understand the implications and treatment in order to minimize unnecessary procedures and morbidity associated with such.
Conversion of primary liver cancer after targeted therapy for liver cancer combined with AFP-targeted CAR T-cell therapy: a case report
Authors: Yun Wang, Yan Zhao, Miaoling Li, Huilian Hou, Zhijie Jian, Weizhi Li, Peijie Li, Fuquan Ma, Mengying Liu, Haibo Liu, Hui Xue
Journal: Front Immunol (2023)
Keywords: afp, case report, chimeric antigen receptor t cell (car-t), hepatocellular carcinoma (hcc), immunotherapy, primary liver cancer (plc)
MeSH terms: Carcinoma, Hepatocellular / pathology, Liver Neoplasms / pathology, Case Reports, Humans, Immunotherapy, Adoptive, Neoplasm Recurrence, Local / metabolism, Receptors, Antigen, T-Cell, T-Lymphocytes, alpha-Fetoproteins / metabolism, alpha-Fetoproteins, Receptors, Antigen, T-Cell

Primary liver cancer (PLC) that originates in the liver is a malignant tumor with the worst prognosis. Hepatocellular carcinoma (HCC) is the most common type of PLC. Most PLC cases are diagnosed at advanced stages mainly due to their insidious onset and rapid progression. Patients with PLC undergo surgical intervention or localized treatment, but their survival is often affected by its high relapse rate. Medical treatment is the primary option for patients with liver cancer, especially with advanced extrahepatic metastases. Molecular targeted therapy exerts an anti-tumor effect by acting on various signaling pathways involved in molecular pathogenesis; however, high drug resistance and low therapeutic responsiveness of PLC to molecular targets challenge the treatment option. In recent years, after surgical intervention, radiotherapy, chemotherapy, and/or molecular targeted therapy, autologous cell immunotherapy has been adopted for PLC. As a typical autologous cell immunotherapy, CAR T-cell therapy uses genetically modified T cells to express tumor-specific chimeric antigen receptors (CARs). Its targeting ability, persistent nature, and tumor-killing function result in a significant impact on the treatment of hematological tumors. However, no breakthrough has happened in the research specific to the curation of lung cancer, liver cancer, breast cancer, and other common solid tumors. In this context, a combination of molecular targeted therapy and CAR T-cell therapy was used to treat a patient with advanced HCC to achieve a partial remission(PR) and facilitate further liver transplantation.
Surgical management of compound odontoma associated with unerupted tooth: a case report
Authors: Fatima Ezzahra Zidane, Youssra Azzouz, Rachid Fawzi
Journal: Pan Afr Med J (2022)
Keywords: odontoma, case report, compound, tumor-like, unerupted
MeSH terms: Maxillary Neoplasms / surgery, Odontogenic Tumors, Odontoma / complications, Odontoma / diagnosis, Odontoma / surgery, Tooth, Impacted / complications, Tooth, Unerupted / complications, Tooth, Unerupted / diagnostic imaging, Tooth, Unerupted / surgery, Case Reports, Child, Humans, Male, Mandible

Compound odontoma has been reported to be the most common of all odontogenic neoplasms and tumor- like lesions. It is a slow-growing, asymptomatic neoplasms found incidentally during a routine radiography examination. In general, the clinical indicators of odontoma may include eruption disturbance (non-eruption of permanent teeth, retention of deciduous teeth), expansion of the cortical bone, teeth malposition and pain. In this case, the presence of odontoma prevented the physiological eruption of permanent mandible incisor. We describe the surgical procedure to remove a compound odontoma of 21 small tooth-like structures localized in the mandible of a child boy associated with an unerupted permanent mandible incisor.
A Case of Multiple Myeloma Misdiagnosed as Seronegative Rheumatoid Arthritis and Review of Relevant Literature
Authors: Scott Schoninger, Yamen Homsi, Alexandra Kreps, Natasa Milojkvovic
Journal: Case Rep Rheumatol (2018)
MeSH terms: Case Reports

Multiple myeloma (MM) is a malignant plasma cell proliferation producing large numbers of monoclonal immunoglobulins. Typical MM symptoms include anemia, renal failure, hypercalcemia, and bone pain. Atypical symptoms have rarely been reported in the literature. We report a case of a 58-year-old male who presented with symmetrical inflammatory polyarthritis and was misdiagnosed with seronegative rheumatoid arthritis (RA). After failing many RA treatments and with further workup, the diagnosis of MM was made. This rare manifestation of MM carries a diagnostic challenge and causes a significant delay in treating such patients. Here, we report this unusual initial presentation with review of several cases in the English literature describing similar presentations.
"They Would Have Stopped Births, if They Only Could have": Short-and Long-Term Impacts of the COVID-19 Pandemic-a Case Study From Bologna, Italy
Authors: Brenda Benaglia, Daniela Canzini
Journal: Front Sociol (2021)
Keywords: covid-19, italy, birth, covidian, maternity care, midwifery, public health, reproductive rights

This article addresses the short-term impacts of the COVID-19 pandemic in Italy and hints at its potential long-term effects. Though many might want it to, birth does not stop during a pandemic. In emergency times, birth practices need to be adjusted to safeguard the health of birthing mothers, babies, birth providers, and the general population. In Bologna, Italy, one of the emergency measures employed by local hospitals in response to COVID-19 was to suspend women's right to be accompanied by a person of their choice for the whole duration of labor and childbirth. In this work, we look at how this measure was disputed by the local activist birth community. Through the analysis of a social campaign empowered by Voci di Nascita-an association of parents, birth providers, and activists-we examine how social actors negotiated the balance between public health and reproductive rights in a time of crisis. We argue that this process unveils several structural issues that characterize maternity care at the local and national levels, including the (re)medicalization of birth, the discourse on risk and safety, the internal fragmentation of Italian midwifery, and the fragility of reproductive rights. The Covidian experience forced the reshaping of the birth carepath during the peak of the emergency. We suggest that it also offered an opportunity to rethink how birth is conceived, experienced, and accompanied in times of unprecedented global uncertainty-and beyond.
Modafinil Induced Psychosis in a Patient with Bipolar 1 Depression
Authors: Alexander A DiSciullo, Clayton D English, William T Horn
Journal: Case Rep Psychiatry (2018)
MeSH terms: Case Reports

Modafinil has been used as an adjunctive medication in the treatment of bipolar 1 depression with reported success. Case reports have been published demonstrating modafinil induced mania in bipolar patients and modafinil induced psychosis in schizophrenic patients. To our knowledge, we report the only case of modafinil induced psychosis in a patient with bipolar depression treated with both mood stabilizers and antipsychotics. In addition, it is the quickest onset to psychosis (2 days) at the lowest dosage of modafinil (100 mg/day) reported in the literature. Although favorable outcomes using modafinil for treatment of bipolar depression have been reported in literature, clinicians should remain cautious of the potential to rapidly induce psychosis with modafinil at low dosages in patients with bipolar depression despite being treated with mood stabilizers and antipsychotics.
Eosinophilic angiocentric fibrosis of the sinonasal tract
Authors: Chunzi Jenny Jin, Bayardo Perez-Ordonez, Ian Witterick
Journal: BJR Case Rep (2016)
MeSH terms: Case Reports

Eosinophilic angiocentric fibrosis (EAF) is an exceedingly rare and potentially disfiguring and obstructing benign lesion involving the upper airways. We report two cases of EAF originating from the nasal cavity in a 31-year-old female and a 58-year-old male exhibiting nasal obstructive symptoms, with imaging features and histopathology characteristic of EAF. Surgical excision was performed on one patient with a disfiguring nasal mass at a tertiary referral rhinology practice within a university centre. Summarized are the relevant clinical issues to increase awareness of this disease. The slow progression and rarity of the disease has previously resulted in diagnostic difficulty. We review the limited current literature surrounding the clinical features and treatment options for this progressive and potentially morbid condition. These cases reinforce that, while rare, inflammatory and fibrosing lesions in general should still be considered as part of the differential diagnosis in patients presenting with obstructive lesions in the sinonasal tract.
Coexistence of Antiphospholipid Syndrome and Heparin-Induced Thrombocytopenia in a Patient with Recurrent Venous Thromboembolism
Authors: Samuel Adediran, Nicole Agostino
Journal: Case Rep Hematol (2017)
MeSH terms: Case Reports

Heparin-induced thrombocytopenia (HIT) is a prothrombotic adverse drug reaction in which heparin forms complexes with platelet factor 4 forming neoantigens that are recognized by autoantibodies. Antiphospholipid syndrome (APS) is similar to HIT in that it is mediated by autoantibodies that are also prothrombotic. We present a case of rare coexistence of antiphospholipid antibody syndrome and heparin-induced thrombocytopenia.
A Reversible Cytotoxic Lesion of the Corpus Callosum Developing after a Rapid Alteration in Cerebrospinal Fluid Pressure/Volume in a Patient with New Daily Persistent Headache
Authors: Todd D Rozen, Hector A Robles
Journal: Case Rep Neurol Med (2020)
MeSH terms: Case Reports

A case is presented of a woman with a history of daily persistent head pressure and dizziness who developed a cytotoxic lesion of the splenium of the corpus callosum after an acute withdrawal of chronic acetazolamide treatment and then, in quick succession, a CSF pressure/volume drop with a lumbar puncture. This is the first documentation that rapid alterations of CSF pressure/volume may trigger cytotoxic lesions in the central nervous system.
Unusual Site for a White Nodule on the Palatine Tonsil: Presentation, Differential Diagnosis, and Discussion
Authors: Ashwag Yagoub Aloyouny
Journal: Case Rep Dent (2021)
MeSH terms: Case Reports

Introduction:
Palatine tonsils are part of the mucosa-associated lymphoid tissue, located in the oropharyngeal region. Although these tissues protect the body from foreign intruders, they are more prone to infections due to their anatomical structure and location. For instance, the differential diagnosis of a white lesion on the palatine tonsil can range from benign to malignant lesions. Oral lymphoepithelial cysts commonly arise as painless, yellowish nodules on the floor of the mouth and the ventral or lateral surface of the tongue. Case Presentation. This paper presents a rare case of an unusual site of a lymphoepithelial cyst (LEC) in the oral cavity. The lesion was located in the tonsil of a 20-year-old woman with a chief complaint of a painless, white lump in the back of the mouth for nine months. Discussion. The differential diagnosis of a white lesion on the palatine tonsil is caused by several factors, such as bacterial, viral, and fungal infections; trauma; stones; cysts; abscess; or cancer. In this case, both the clinical presentation and extra- and intraoral examinations were highly associated with LEC. Oral LEC etiopathogenesis is uncertain, and several theories have been proposed to discuss the causes of LEC. In addition, oral LEC could be monitored without surgical intervention if the nodule is asymptomatic.
Conclusion:
We emphasize the importance of a thorough clinical examination of oral and oropharyngeal lesions, which are usually neglected.
New Regions With Molecular Alterations in a Rare Case of Insulinomatosis: Case Report With Literature Review
Authors: Kirill Anoshkin, Ivan Vasilyev, Kristina Karandasheva, Mikhail Shugay, Valeriya Kudryavtseva, Alexey Egorov, Larisa Gurevich, Anna Mironova, Alexey Serikov, Sergei Kutsev, Vladimir Strelnikov
Journal: Front Endocrinol (Lausanne) (2021)
Keywords: cebpa, foxl2, irs2, copy number variation, insulinomatosis, neuroendocrine tumors
MeSH terms: DNA Copy Number Variations, Insulinoma / genetics, Pancreatic Neoplasms / genetics, Case Reports, Research Support, Non-U.S. Gov't, Review, Aged, Humans, Insulinoma / pathology, Male, Middle Aged, Pancreas / pathology, Pancreatic Neoplasms / pathology

Insulinomatosis is characterized by monohormonality of multiple macro-tumors and micro-tumors that arise synchronously and metachronously in all regions of the pancreas, and often recurring hypoglycemia. One of the main characteristics of insulinomatosis is the presence of insulin-expressing monohormonal endocrine cell clusters that are exclusively composed of proliferating insulin-positive cells, are less than 1 mm in size, and show solid islet-like structure. It is presumed that insulinomatosis affects the entire population of β-cells. With regards to molecular genetics, this phenomenon is not related to mutation in MEN1 gene and is more similar to sporadic benign insulinomas, however, at the moment molecular genetics of this disease remains poorly investigated. NGS sequencing was performed with a panel of 409 cancer-related genes. Results of sequencing were analyzed by bioinformatic algorithms for detecting point mutations and copy number variations. DNA copy number variations were detected that harbor a large number of genes in insulinoma and fewer genes in micro-tumors. qPCR was used to confirm copy number variations at ATRX, FOXL2, IRS2 and CEBPA genes. Copy number alterations involving FOXL2, IRS2, CEBPA and ATRX genes were observed in insulinoma as well as in micro-tumors samples, suggesting that alterations of these genes may promote malignization in the β-cells population.