OpenMed/multicare-articles huggingface dataset:
Impairment of bimanual in-phase movement during recovery from frontal lobe tumor surgery: a case report
Authors: Kozue Takada, Takuya Yamaguchi, Yuko Hyuga, Yuto Mitsuno, Satoshi Horiguchi, Masako Kinoshita, Takeshi Satow
Journal: Front Neurosci (2023)
Keywords: bimanual movement, frontal lobe, motor coordination, premotor cortex, primary motor cortex, supplementary motor area
MeSH terms: Case Reports

The mechanisms underlying bimanual coordination have not yet been fully elucidated. Here, we evaluated the clinical features of bimanual movement impairment in a patient following surgery for a frontal lobe tumor. The patient was an 80-year-old man who had undergone subtotal tumor resection for a tumor in the right superior frontal gyrus. Histological examination of the resected specimen led to the diagnosis of malignant lymphoma of the diffuse large B-cell type, and the patient subsequently received high-dose methotrexate-based chemotherapy. Postoperatively, the patient had difficulty with bimanual movement, and on the 5th postoperative day we found that the impairment could not be attributed to weakness. Temporal changes in the characteristics of manual movements were analyzed. Bimanual diadochokinesis (opening/closing of the hands, pronation/supination of the forearms, and sequential finger movements) was more disturbed than unilateral movements; in-phase movements were more severely impaired than anti-phase movements. Bimanual movement performance was better when cued using an auditory metronome. On the 15th postoperative day, movements improved. The present observations show that in addition to the disturbance of anti-phase bimanual movements, resection of the frontal lobe involving the supplementary motor area (SMA) and premotor cortex (PMC) can cause transient impairment of in-phase bimanual diadochokinesis, which can be more severe than the impairment of anti-phase movements. The effect of auditory cueing on bimanual skills may be useful in the diagnosis of anatomical localization of the superior frontal gyrus and functional localization of the SMA and PMC and in rehabilitation of patients with brain tumors, as in the case of degenerative movement disorders.
From trauma to resilience: advancing cultural responsiveness and equity in the Muskowekwan First Nation's healing journey
Authors: JoLee Sasakamoose, Shauneen Pete, Fred O'Soup, Tiffany Wolfe
Journal: Front Public Health (2024)
Keywords: indigenous community health, indigenous community resilience, indigenous healing practices, justice, diversity, equity, inclusion (j-dei), cultural responsiveness, historic trauma, mental health and wellness, residential schools in canada
MeSH terms: Indians, North American / psychology, Resilience, Psychological, Community-Based Participatory Research, Cultural Competency, Female, Humans, Male, Saskatchewan

Introduction:
The Muskowekwan First Nation (MFN) in Saskatchewan, Canada, epitomizes the enduring strength and cultural preservation of the Saulteaux people. This community faces the lasting effects of colonial trauma, especially the violence, abuse, and adversity experienced by students at the Muskowequan Indian Residential School (MIRS). Decades of abuse by institutional leaders caused generational trauma, contributing to current mental health and well-being challenges. This study highlights the community's role in sharing experiences and shaping healing processes to develop the MFN Family Healing and Wellness Centre in response to urgent community concerns. It examines the integration of Justice, Diversity, Equity, and Inclusion (J-DEI) principles and cultural responsiveness in fostering community resilience and mental well-being.
Methods:
Adopting a community-based participatory research framework, this study employs a mixed-methods approach, including community engagement sessions and surveys. Collaborating closely with the MFN leadership, it draws upon the specialized expertise of Author2 and Author1, leaders in Indigenous health and research. The research uses qualitative and quantitative data collection, emphasizing the importance of community input and leadership in shaping the research process and outcomes.
Results:
Findings emphasize the community's commitment to spiritual and cultural practices as vital healing components. Amidst the heightened awareness of the lingering effects of the MIRS within the MFN community, these insights informed the development of the Centre, ensuring it incorporates the community's desires for culturally relevant healing practices. The grand opening of Phase I of the Centre in February 2023 emerged as a significant step forward, symbolizing a move towards holistic community health that honors resilience, holistic wellness, and cultural continuity.
Discussion:
This case study contributes to the literature on integrated, culturally responsive healthcare models that address the needs of Indigenous peoples and communities. The study provides insights to guide the Centre's future programs and services, ensuring they are culturally tailored and responsive to the community's needs. By illustrating the potential for traditional wisdom and contemporary health practices to foster well-being, the case study advocates for holistic approaches to healing in Indigenous settings, offering a replicable framework for similar initiatives globally.
Management of Neglected Pubic Symphysis Diastasis and Sacroiliac Joint Disruption With Erectile Dysfunction in Polytrauma: A Case Report
Authors: Dilip Kumar Naidu, Aswin S, Madhan R, Gowthaman N, Kevin Dhas
Journal: Cureus (2024)
Keywords: erectile dysfunction, neglected orthopaedic injury, neglected pubic diastasis injury, pelvic fracture, pelvic ring injury, polytrauma, post traumatic erectile dysfunction, road traffic injuries, sacroiliac joint fixation, sacroiliac screw
MeSH terms: Case Reports

Pelvic fractures are the most common among patients sustaining high-energy trauma. They are associated with high morbidity and mortality rates, often because of high blood loss and injury to the lumbosacral plexus, genitourinary system, and gastrointestinal system. The age, complexity of the pelvic fracture, and pubic symphysis diastasis would represent risk factors for erectile dysfunction after major and neglected pelvic injuries; the neglected pelvic ring injuries could cause disabilities that manifest with symptoms like pain, lower limb length discrepancy, standing or sitting imbalance and even sexual dysfunction. Herein, we report a case of a young adult who sustained polytrauma and was diagnosed with neglected pubic symphysis diastasis, sacroiliac joint disruption, and erectile dysfunction. The patient regained erectile function after the surgical management of pubic symphysis diastasis and sacroiliac joint disruption.
Novel heterozygous TREX1 mutation in a juvenile systemic lupus erythematosus patient with severe cutaneous involvement treated successfully with Jak-inhibitors: a case report
Authors: Martina Rossano, Emilio Amleto Conti, Paola Bocca, Stefano Volpi, Antonio Mastrangelo, Riccardo Cavalli, Marco Gattorno, Francesca Minoia, Giovanni Filocamo
Journal: Front Immunol (2023)
Keywords: jak-inhibitor, trex1, baricitinib, case report, pediatrics, systemic lupus erythematosus
MeSH terms: Interferon Type I / genetics, Janus Kinase Inhibitors / therapeutic use, Lupus Erythematosus, Systemic / drug therapy, Lupus Erythematosus, Systemic / genetics, Case Reports, Research Support, Non-U.S. Gov't, Adolescent, Female, Genome-Wide Association Study, Humans, Mutation, Janus Kinase Inhibitors, three prime repair exonuclease 1, Interferon Type I

Juvenile systemic lupus erythematosus (jSLE) is a complex inflammatory autoimmune disorder. In the last decades, genetic factors and activation pathways have been increasingly studied to understand their potential pathogenetic role better. Genetic and transcriptional abnormalities directly involved in the type I interferon (IFN) signaling cascade have been identified through family-based and genome-wide association studies. IFNs trigger signaling pathways that initiate gene transcription of IFN-stimulated genes through the activation of JAK1, TYK2, STAT1, and STAT2. Thus, the use of therapies that target the IFN pathway would represent a formidable advance in SLE. It is well known that JAK inhibitors have real potential for the treatment of rheumatic diseases, but their efficacy in the treatment of SLE remains to be elucidated. We report the case of a 13-year-old girl affected by jSLE, carrying a novel heterozygous missense variant on Three prime Repair EXonuclease 1 (TREX1), successfully treated with baricitinib on top of mofetil mycophenolate. The TREX1 gene plays an important role in DNA damage repair, and its mutations have been associated with an overproduction of type 1 interferon. This report underlines the role of translational research in identifying potential pathogenetic pathways in rare diseases to optimize treatment.
Abdominal rhabdoid tumor presenting with symptomatic spinal epidural compression in a newborn. A case report
Authors: Shana Montalto, Michela Di Filippo, Valeria Capra, Carla Manzitti, Angela Rita Sementa, Patrizia De Marco, Marzia Ognibene, Fiammetta Sertorio, Stefania Sorrentino
Journal: Front Pediatr (2024)
Keywords: case report, newborn, oncological emergency, rhabdoid tumor, spinal compression
MeSH terms: Case Reports

The occurrence of an abdominal tumor invading the spinal canal and causing symptoms of epidural compression is rare in an infant, and exceptional at birth. Peripheral neuroblastic tumors are by far the most common cause. Emergency chemotherapy is commonly curative, though permanent sequelae are possible. Although other malignancies may be involved, no case of rhabdoid tumors at birth has been reported. We describe the case of a neonate who presented symptoms of spinal epidural compression at birth secondary to a rhabdoid tumor. As expected with this highly malignant tumor, the patient experienced a rapidly progressive clinical course and died within three months of diagnosis.
Syringomatous tumor of the nipple: a case report
Authors: Ana Vitória de Jesus Félix, Larissa Vasconcelos Silva, Rafael Everton Assunção Ribeiro da Costa, Maria Júlia Andrade Pereira Soares, Raniere Francisco de Oliveira Sobrinho, Maria Clara Amorim Silva, Raimundo Gerônimo da Silva Júnior, Sabas Carlos Vieira
Journal: Pan Afr Med J (2024)
Keywords: breast tumors, case report, nipples, pathology
MeSH terms: Breast Neoplasms / diagnosis, Breast Neoplasms / pathology, Breast Neoplasms / surgery, Nipples / pathology, Syringoma / diagnosis, Syringoma / pathology, Syringoma / surgery, Ultrasonography, Mammary, Case Reports, Adult, Female, Follow-Up Studies, Humans, Mammaplasty / methods, Sweat Gland Neoplasms / diagnosis, Sweat Gland Neoplasms / pathology, Sweat Gland Neoplasms / surgery

Syringomatous tumor of the nipple is a benign, locally infiltrative tumor. There are reports in the literature of tumor recurrence in cases of incomplete excision. Clinical and mammographic findings in syringomatous tumors are like those of breast carcinoma and the pathologist has a fundamental role in final tumor diagnosis. Therefore, the aim of this study was to report a case of syringoma located in the areolar region. A 33-year-old woman reported that she had noticed a nodule in her left areolar region 4 years previously (February 2019). A breast ultrasound was performed, detecting intraparenchymatous breast cysts. Surgical resection of the nodule was indicated although it was not performed. Two years later, in August 2021, the patient underwent a mastopexy with prosthesis inclusion. Histopathology study of the surgical specimen revealed a syringomatous tumor with positive margins. Thirteen (13) months after diagnosis (September 3, 2021 - October 16, 2022), the patient is doing well and receives clinical follow-up.
A Successful Treatment of COVID-Induced Acute Idiopathic Pancreatitis with an RNA-Polymerase Inhibitor Agent
Authors: Ana P Urena Neme, An Tran, Michael Victoria Guerrero, Gabriella Roa Gomez, Miguel A Rodriguez Guerra
Journal: Cureus (2024)
Keywords: acute sars-cov-2, covid pancreatitis, nucleotide analog, remdesivir, rna polymerase inhibitor
MeSH terms: Case Reports

Acute idiopathic pancreatitis (AIP) has been rarely linked to SARS-CoV-2 and its mechanism is not completely understood. As a result, its management, due to the heterogeneity of the literature, may pose a challenge. This case report describes a 59-year-old female who presented to the emergency department with severe epigastric pain, fever, and a positive SARS-CoV-2 polymerase chain reaction (PCR) test. Imaging confirmed acute interstitial pancreatitis, which was successfully managed using the viral RNA polymerase inhibitor, remdesivir. Pancreatitis-associated complications, such as sepsis and shock, are recognized as significant factors contributing to extended hospitalization and increased mortality rates. The management of autoimmune pancreatitis poses a challenge due to the diverse existing literature, resulting in a lack of standardized approaches. Although the impact on inpatient mortality of remdesivir remains uncertain, early administration of RNA polymerase inhibitors could alleviate complications and positively impact the duration of hospitalization. Further research is important to create optimal management strategies for complications related to COVID-19-related pancreatitis.
Case Report: CD19 CAR T-cell therapy following autologous stem cell transplantation: a successful treatment for R/R CD20-negative transformed follicular lymphoma with TP53 mutation
Authors: Jinjing Zhang, Dali Cai, Ran Gao, Yuan Miao, Yan Cui, Zhenghua Liu, Heyang Zhang, Xiaojing Yan, Nan Su
Journal: Front Immunol (2023)
Keywords: tp53 mutation, autologous stem cell transplantation, chimeric antigen receptor t-cell, diffuse large b-cell lymphoma, transformed follicular lymphoma
MeSH terms: Hematopoietic Stem Cell Transplantation, Lymphoma, Follicular / genetics, Lymphoma, Follicular / therapy, Lymphoma, Large B-Cell, Diffuse / genetics, Lymphoma, Large B-Cell, Diffuse / therapy, Lymphoma, Non-Hodgkin / etiology, Case Reports, Adult, Humans, Immunotherapy, Adoptive / adverse effects, Male, Neoplasm Recurrence, Local / therapy, Transplantation, Autologous, Tumor Suppressor Protein p53, TP53 protein, human, Tumor Suppressor Protein p53

Background:
Follicular lymphoma (FL), a common indolent B-cell lymphoma, has the potential to transform into an aggressive lymphoma, such as diffuse large B-cell lymphoma (DLBCL). The outcome of patients with transformed follicular lymphoma (tFL) is poor, especially in patients with transformed lymphoma after chemotherapy and patients with progression within 24 months (POD24). Chimeric antigen receptor (CAR) T-cell therapy combined with autologous stem cell transplantation (ASCT) has promising antitumor efficacy.
Case presentation:
Here, we described a 39-year-old male patient who was initially diagnosed with FL that transformed into DLBCL with POD24, CD20 negativity, TP53 mutation, and a bulky mass after 3 lines of therapy, all of which were adverse prognostic factors. We applied a combination approach: CD19 CAR T-cell infusion following ASCT. Ibrutinib was administered continuously to enhance efficacy, DHAP was administered as a salvage chemotherapy, and ICE was administered as a bridging regimen. The patient underwent BEAM conditioning on days -7~ -1, a total of 3.8 × 106/kg CD34+ stem cells were infused on days 01~02, and a total of 108 CAR T cells (relmacabtagene autoleucel, relma-cel, JWCAR029) were infused on day 03. The patient experienced grade 2 cytokine release syndrome (CRS), manifesting as fever and hypotension according to institutional standards. There was no immune effector cell-associated neurotoxicity syndrome (ICANS) after CAR T-cell infusion. Finally, the patient achieved CMR at +1 month, which has been maintained without any other adverse effects.
Conclusion:
This case highlights the amazing efficacy of CD19 CAR T-cell therapy following ASCT for R/R tFL, thus providing new insight on therapeutic strategies for the future.
A Case of Fish Sausage Anaphylaxis Induced by Epicutaneous Sensitization to Carmine Contained in Eyeshadows: The Effect of Chelation on Carmine Allergy
Authors: Maiko Yamaura, Yuriko Iwahashi, Eri Hashimoto, Jun Miura, Yuri Murayama, Sachiko Koshikawa, Naoko Inomata
Journal: Case Rep Dermatol Med (2024)
MeSH terms: Case Reports

Carmine is an aluminium and/or calcium-chelated complex form of carminic acid (CA), which is derived from the Dactylopius coccus extract (cochineal), and is globally used as a red-colourant in foods and cosmetics. Although several allergens in carmine allergies, such as CC38K, have been reported, it remains unknown whether chelation affects the allergenicity of carmine. We report a case of Japanese fish sausage (Gyoniku Sausage) anaphylaxis induced by epicutaneous sensitization to carmine contained in eyeshadows. In addition, we report on the effect of chelation on carmine allergy. A 32-year-old woman had experienced itching, wheals, and swelling of her eyelids immediately after applying pink eyeshadows, which contained carmine, on several occasions for 3 years. Two months ago, she developed itching, wheals, and swelling on her whole body, especially her eyelids, and dyspnea immediately after ingesting fried pink fish sausages, which contained cochineal. In skin prick tests (SPTs) with all ingredients ingested in the two episodes of anaphylaxis, only fish sausage was positive. SPT was also positive for carmine. In IgE-immunoblotting using the eyeshadow and fish sausage, the patient serum IgE was bound to three protein bands at approximately 86, 114, and 130 kDa. In addition, IgE-immunoblotting using the carmine showed a broad band at 86-130 kDa, which were consistent with those using the eyeshadow and fish sausage, whereas there is no band using CA. Interestingly, the protein bands using the eyeshadow and carmine were diminished by preincubation in the presence of ethylenediaminetetraacetic acid (EDTA) as a chelating agent. The results indicated that the causative allergens of carmine contained in the eyeshadows could be dechelated by EDTA, reducing its allergenicity. In conclusion, carmine contained in cosmetics can cause epicutaneous sensitisation and consequently can induce food anaphylaxis. To prevent sensitisation in carmine allergy, the effect of chelation on allergenicity of carmine should be considered.
Early Reconstruction with Locoregional-Free Flaps in Post-COVID-19 Rhino-orbital-cerebral Mucormycosis Craniofacial Deformities: A Single-Center Clinical Experience from India
Authors: Veena K Singh, Ansarul Haq, Sarsij Sharma, Anupama Kumari
Journal: Surg J (N Y) (2024)
Keywords: covid-19, facial, mucormycosis, reconstruction

Aim of the Study Mucormycosis is a rare invasive and fatal fungal infection and its resurgence in coronavirus disease 2019 (COVID-19) patients has been a matter of grave concern. It is essentially a medical disease, but surgical debridement of necrotic tissues is of paramount importance leading to severe craniofacial deformities. In this case series, we present our experience with the feasibility of early reconstruction after surgical debridement. Case Series As a Dedicated COVID Center (DCH), the institute received the largest population of COVID-19 mucormycosis patients from the entire eastern region of the country between May 2021 and August 2021. More than 5,000 COVID-19 were admitted out of which 218 patients were diagnosed with mucormycosis. Nine patients, seven males and two females, with a mean age of 39 years with craniofacial mucormycosis underwent debridement and early reconstructions (2-4 weeks from first debridement and start of antifungal therapy) with free and pedicled flaps. All flaps survived and showed no evidence of recurrence. The average time of the early reconstruction after surgical debridement was 1.7 weeks once the course of systemic amphotericin B was received. Conclusion After aggressive surgical resection and a short course of antifungal therapy, early reconstruction can be done safely based on clinical criteria, as long as there is no evidence of hyphae invasion on wound edges in the intraoperative pathology examination.
Perceived factors informing the pre-acceptability of digital health innovation by aging respiratory patients: a case study from the Republic of Ireland
Authors: Tara Byrne, Niall Murray, Mary McDonnell-Naughton, Neil J Rowan
Journal: Front Public Health (2023)
Keywords: aging, digital health, education, living labs, quintuple helix hub, respiratory health
MeSH terms: Aging, Delivery of Health Care, Research Support, Non-U.S. Gov't, Humans, Ireland, Monitoring, Physiologic

It is appreciated that digital health is increasing in interest as an important area for efficiently standardizing and developing health services in Ireland, and worldwide. However, digital health is still considered to be in its infancy and there is a need to understand important factors that will support the development and uniform uptake of these technologies, which embrace their utility and ensure data trustworthiness. This constituted the first study to identify themes believed to be relevant by respiratory care and digital health experts in the Republic of Ireland to help inform future decision-making among respiratory patients that may potentially facilitate engagement with and appropriate use of digital health innovation (DHI). The study explored and identified expert participant perceptions, beliefs, barriers, and cues to action that would inform content and future deployment of living labs in respiratory care for remote patient monitoring of people with respiratory diseases using DHI. The objective of this case study was to generate and evaluate appropriate data sets to inform the selection and future deployment of an ICT-enabling technology that will empower patients to manage their respiratory systems in real-time in a safe effective manner through remote consultation with health service providers. The co-creation of effective DHI for respiratory care will be informed by multi-actor stakeholder participation, such as through a Quintuple Helix Hub framework combining university-industry-government-healthcare-society engagements. Studies, such as this, will help bridge the interface between top-down digital health policies and bottom-up end-user engagements to ensure safe and effective use of health technology. In addition, it will address the need to reach a consensus on appropriate key performance indicators (KPIs) for effective uptake, implementation, standardization, and regulation of DHI.