OpenMed/multicare-articles huggingface dataset:
Does artesunate prolong the electrocardiograph QT interval in patients with severe malaria?
Authors: Richard J Maude, Katherine Plewes, M Abul Faiz, Josh Hanson, Prakaykaew Charunwatthana, Sue J Lee, Joel Tärning, Emran Bin Yunus, M Gofranul Hoque, Mahatab Uddin Hasan, Amir Hossain, Niklas Lindegardh, Nicholas P J Day, Nicholas J White, Arjen M Dondorp
Journal: Am J Trop Med Hyg (2009)
MeSH terms: Antimalarials / therapeutic use, Artemisinins / therapeutic use, Electrocardiography / drug effects, Long QT Syndrome / chemically induced, Malaria / drug therapy, Malaria / physiopathology, Case Reports, Adult, Antimalarials / blood, Antimalarials / pharmacokinetics, Artemisinins / blood, Artemisinins / pharmacokinetics, Artesunate, Blood Pressure / drug effects, Ethanolamines / therapeutic use, Fluorenes / therapeutic use, Glasgow Coma Scale, Heart Rate / drug effects, Humans, Long QT Syndrome / prevention & control, Lumefantrine, Male, Patient Selection, Antimalarials, Artemisinins, Ethanolamines, Fluorenes, Artesunate, Lumefantrine

Several antimalarials can cause significant prolongation of the electrocardiograph QT interval, which can be associated with an increased risk of potentially lethal ventricular arrhythmias. High doses of artemether and artemotil have been associated with QT prolongation in dogs, raising the possibility of a class effect with the artemisinin derivatives. Serial electrocardiograms were recorded, and QTc interval was calculated before and after administration of artesunate by intravenous injection in patients with severe falciparum malaria in Bangladesh. Of 21 adult patients with severe malaria enrolled, 8 (38%) died. The mean QTc interval was unaffected by bolus intravenous artesunate (2.4 mg/kg). In two patients, the QTc interval exceeded 0.5 seconds, but in both cases, an alternative explanation was plausible. No effect was observed on the JTc or PR interval, QRS width, blood pressure, or heart rate. Intravenous artesunate does not have significant cardiovascular effects in patients with severe falciparum malaria.
Donor-Derived CD7 CAR-T Therapy Followed by Allogeneic Hematopoietic Stem Cell Transplantation for Acute T-Lymphocytic Leukemia Associated With Hepatitis B: A Case Report
Authors: Zhihui Li, Fanqiao Meng, Jing Li, Tong Wu
Journal: Front Immunol (2022)
Keywords: allogeneic hematopoietic stem cell transplantation, donor-derived chimeric antigen receptor t cells, hepatitis b virus, relapsed/refractory acute t-lymphocytic leukemia, stem cell transplantation
MeSH terms: Hematopoietic Stem Cell Transplantation / adverse effects, Hepatitis B / complications, Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Receptors, Chimeric Antigen, Case Reports, Research Support, Non-U.S. Gov't, Antigens, CD19, Humans, T-Lymphocytes, Antigens, CD19, Receptors, Chimeric Antigen

The use of chimeric antigen receptor T cells (CAR-Ts) is effective in the treatment of hematological malignancies. It has been reported that HBV is reactivated after CAR-T immunotherapy for refractory/relapsed hematological malignant B-cell tumors. However, there is little literature on donor-derived CAR-T therapy combined with allogeneic hematopoietic stem cell transplantation in hepatitis B patients with acute T-lymphocytic leukemia. We report the case of one patient with hepatitis B associated with relapsed/refractory acute T-lymphocytic leukemia (T-ALL) treated with donor-derived CD7 CAR-T therapy and allogeneic hematopoietic stem cell transplantation. During treatment, the copy number of hepatitis B virus continuously decreased, and AST, ALT, DBIL and TBIL remained within the controllable ranges. CD7-negative MRD recurred 4.5 months after transplantation, and the flow cytometry results became negative after immunosuppressive reduction. Seven months after transplantation, the patient had complete remission, and the copy number of hepatitis B virus decreased to below 102. This is the first study on the safety and effectiveness of donor-derived CD7 CAR-T therapy bridging to allogeneic hematopoietic stem cell transplantation in a patient with relapsed/refractory acute T-lymphocytic leukemia and hepatitis B.
Eating disorders in schizophrenia: implications for research and management
Authors: Youssef Kouidrat, Ali Amad, Jean-Daniel Lalau, Gwenole Loas
Journal: Schizophr Res Treatment (2014)
MeSH terms: Review

Objective. Despite evidence from case series, the comorbidity of eating disorders (EDs) with schizophrenia is poorly understood. This review aimed to assess the epidemiological and clinical characteristics of EDs in schizophrenia patients and to examine whether the management of EDs can be improved. Methods. A qualitative review of the published literature was performed using the following terms: "schizophrenia" in association with "eating disorders," "anorexia nervosa," "bulimia nervosa," "binge eating disorder," or "night eating syndrome." Results. According to our literature review, there is a high prevalence of comorbidity between schizophrenia and EDs. EDs may occur together with or independent of psychotic symptoms in these patients. Binge eating disorders and night eating syndromes are frequently found in patients with schizophrenia, with a prevalence of approximately 10%. Anorexia nervosa seems to affect between 1 and 4% of schizophrenia patients. Psychopathological and neurobiological mechanisms, including effects of antipsychotic drugs, should be more extensively explored. Conclusions. The comorbidity of EDs in schizophrenia remains relatively unexplored. The clearest message of this review is the importance of screening for and assessment of comorbid EDs in schizophrenia patients. The management of EDs in schizophrenia requires a multidisciplinary approach to attain maximized health outcomes. For clinical practice, we propose some recommendations regarding patient-centered care.
Successful Diagnoses and Remarkable Metabolic Disorders in Patients With Solitary Hypothalamic Mass: A Case Series Report
Authors: Boni Xiang, Quanya Sun, Min He, Wei Wu, Bin Lu, Shuo Zhang, Zhaoyun Zhang, Yehong Yang, Yiming Li, Yue Wu, Zhenwei Yao, Haixia Cheng, Li Pan, Qing Miao, Yongfei Wang, Hongying Ye
Journal: Front Endocrinol (Lausanne) (2021)
Keywords: hypopituitarism, hypothalamic obesity, hypothalamus, metabolic disorders, stereotactic biopsy
MeSH terms: Hypothalamic Diseases / diagnosis, Metabolic Diseases / diagnosis, Case Reports, Research Support, Non-U.S. Gov't, Adolescent, Adult, Aged, Biopsy, Blood Glucose, Body Mass Index, Female, Hormones / blood, Humans, Hypothalamic Diseases / blood, Hypothalamic Diseases / pathology, Hypothalamic Diseases / surgery, Hypothalamus / diagnostic imaging, Hypothalamus / pathology, Hypothalamus / surgery, Magnetic Resonance Imaging, Male, Metabolic Diseases / blood, Metabolic Diseases / pathology, Metabolic Diseases / surgery, Middle Aged, Retrospective Studies, Young Adult, Blood Glucose, Hormones

Background:
Solitary intracranial hypothalamic mass occurs rarely. The etiological diagnosis of solitary hypothalamus lesion is challenging and often unachievable. Although previous studies indicated that lesions affecting the hypothalamus often cause significant metabolic disorders, few reports about the metabolic disturbances of patients with solitary hypothalamic mass have been reported.
Method:
Twenty-five patients with solitary hypothalamus lesions who had been evaluated and treated in Huashan Hospital from January 2010 to December 2020 were retrospectively enrolled. The clinical manifestations, radiological features, endocrine and metabolic disorders, and pathology were analyzed.
Results:
The male to female ratio was 5/20. The median age of onset was 22 (19, 35) years old. The most common initial symptom was polydipsia/polyuria (19/25, 76.0%) and amenorrhea (9/20, 45.0%). A high prevalence of hypopituitarism of different axes was found, with almost all no less than 80%. Central hypogonadism (21/22, 95.5%) and central diabetes insipidus (19/21, 90.5%) were the top two pituitary dysfunctions. Conclusive diagnoses were achieved by intracranial surgical biopsy/resection or stereotactic biopsy in 16 cases and by examining extracranial lesions in 3 cases. The pathological results were various, and the most common diagnoses were Langerhans cell histiocytosis (7/19) and hypothalamitis (5/19). The mean timespan from onset to diagnosis in the 19 cases was 34 ± 26 months. Metabolic evaluations revealed remarkable metabolic disorders, including hyperlipidemia (13/16, 81.3%), hyperglycemia (10/16, 62.5%), hyperuricemia (12/20, 60%), overweight/obesity (13/20, 65.0%), and hepatic adipose infiltration (10/13, 76.6%).
Conclusion:
Either surgical or stereotactic biopsy will be a reliable and relatively safe procedure to help to confirm the pathological diagnosis of solitary hypothalamic mass. Metabolic disorders were severe in patients with solitary hypothalamic mass. The management of such cases should cover both the treatment of the primary disease, as well as the endocrine and metabolic disorders.
A Case of Pulmonary Epithelioid Hemangioendothelioma with Literature Review
Authors: Thu Thu Aung, Andrew Chu, Divya Kondapi, Danny Markabawi, Kanish Mirchia, Pratibha Kaul
Journal: Case Rep Oncol Med (2020)
MeSH terms: Case Reports

Pulmonary epithelioid hemangioendothelioma is a rare vascular tumor and infrequently described in medical literature as case reports and case series. Diagnosis is often incidental with high index of histopathological suspicion from clinical pathologist. The pathological pattern is quite unique with distinct immunohistochemical stains. Up to this day, there is no established standard treatment owing to the scarcity of this tumor. In this case report, we describe a case of pulmonary epithelioid hemangioendothelioma unexpectedly diagnosed with transthoracic needle biopsy, along with a review of the current literature.
Endoscope-assisted resection of cavernous angioma at the foramen of Monro: a case report
Authors: Yuji Matsumoto, Kazuhiko Kurozumi, Yousuke Shimazu, Tomotsugu Ichikawa, Isao Date
Journal: Springerplus (2016)
Keywords: cavernous angioma, foramen of monro, neuroendoscope-assisted surgery

Introduction:
Intraventricular cavernous angiomas are rare pathological entities, and those located at the foramen of Monro are even rarer. We herein present a case of cavernous angioma at the foramen of Monro that was successfully treated by neuroendoscope-assisted surgical removal, and review the relevant literature.
Case presentation:
A 65-year-old woman had experienced headache and vomiting for 10 days before admission to another hospital. Magnetic resonance imaging (MRI) showed a mass at the foramen of Monro, and obstructive hydrocephalus of both lateral ventricles. The patient was then referred to our hospital. Neurological examination on admission to our hospital showed memory disturbance (Mini-Mental State Examination 20/30) and wide-based gait. A cavernous angioma at the foramen of Monro was diagnosed based on the typical popcorn-like appearance of the lesion on MRI. The lesion was completely removed by neuroendoscope-assisted transcortical surgery with the Viewsite Brain Access System (Vycor Medical Inc., Boca Raton, FL), leading to a reduction in the size of the ventricles. The resected mass was histologically confirmed to be cavernous angioma. The patient's symptoms resolved immediately and there were no postoperative complications.
Conclusion:
Minimally invasive neuroendoscope-assisted surgery was used to successfully treat a cavernous angioma at the foramen of Monro.
Case Report: Stage IIIc primary malignant mixed Müllerian tumor of the fallopian tube: A case of 5-year disease-free survival after cytoreductive surgery combined with peritoneal resection and adjuvant chemotherapy with paclitaxel plus carboplatin
Authors: Xiaoli Xiao, Ruiqing Ma, Lianyao Shi, Cong Wang, Jie Chen, Yiyan Lu, Yufeng Wang, Xichao Zhai, Fengxian Fu
Journal: Front Oncol (2022)
Keywords: cytoreduction score, cytoreductive surgery (crs), malignant mixed müllerian tumor (mmmt), postoperative chemotherapy (poct), tumor-free survival
MeSH terms: Case Reports

Malignant mixed Müllerian tumor (MMMT) of the fallopian tube is rare and has a poor prognosis. For the patient with fallopian tube MMMT, complete resection of the tumor invading the viscera and the peritoneum is a prerequisite for long-term survival. We report a case of stage IIIc MMMT of the fallopian tube treated by cytoreductive surgery (CRS), peritoneal resection, and adjuvant chemotherapy (paclitaxel plus carboplatin), with 5-year tumor-free survival. Postoperative chemotherapy combining platinum and paclitaxel is the most potent adjuvant therapy.
Case report: Resolution of malignant canine mast cell tumor using ketogenic metabolic therapy alone
Authors: Thomas N Seyfried, Purna Mukherjee, Derek C Lee, Linh Ta, Loren Nations
Journal: Front Nutr (2023)
Keywords: aerobic fermentation, calorie restriction, canine, glucose, ketogenic diet, nutrition
MeSH terms: Case Reports

Background:
Mast cell tumors (MCT) are common neoplasms in dogs and are similar to most other malignant cancers in requiring glucose for growth, regardless of histological grade. Ketogenic metabolic therapy (KMT) is emerging as a non-toxic nutritional intervention for cancer management in animals and humans alike. We report the case of a 7 years-old Pit Bull terrier that presented in 2011 with a cutaneous mast cell tumor under the right nostril.
Methods:
The patient's parent refused standard of care (SOC) and steroid medication after initial tumor diagnosis due to the unacceptable adverse effects of these treatments. Following tumor diagnosis, the patient's diet was switched from Ol'Roy dog food to raw vegetables with cooked fish. The tumor continued to grow on this diet until July, 2013 when the diet was switched to a carbohydrate free, raw calorie restricted ketogenic diet consisting mostly of chicken and oils. A dog food calculator was used to reduce calories to 60% (40% calorie restriction) of that consumed on the original diet. A total of 444 kilocalories were given twice/day at 12 h intervals with one medium-sized raw radish given as a treat between each meal.
Results:
The tumor grew to about 3-4 cm and invaded surrounding tissues while the patient was on the raw vegetable, cooked fish diet. The tumor gradually disappeared over a period of several months when the patient was switched to the carbohydrate free calorie restricted ketogenic diet. The patient lost 2.5 kg during the course of the calorie restriction and maintained an attentive and active behavior. The patient passed away without pain on June 4, 2019 (age 15 years) from failure to thrive due to an enlarged heart with no evidence of mast cell tumor recurrence.
Conclusion:
This is the first report of a malignant cutaneous mast cell tumor in a dog treated with KMT alone. The resolution of the tumor in this canine patient could have been due to the diet-induced energy stress and the restriction of glucose-driven aerobic fermentation that is essential for the growth of most malignant tumors. Further studies are needed to determine if this non-toxic dietary therapeutic strategy could be effective in managing other canine patients with malignant mast cell tumors.
Surgical resection of a giant cardiac angiosarcoma and reconstruction of involved right heart structures: A case report
Authors: Andreea Blindaru, Alexandru Vasilescu, Andrei Danet, Oana Zimnicaru, Maximilian Cristu, Stefan Tudorica, Tudor Borjog, Oana Patrascu, Catalin Constantin Badiu
Journal: Front Cardiovasc Med (2023)
Keywords: angiosarcoma of the heart, cardiac angiosarcoma, case report, primary cardiac tumor, surgery for cardiac angiosarcoma, surgical resection of giant cardiac angiosarcoma
MeSH terms: Case Reports

We present the case of a young woman without a medical history who presented with a giant right atrial, transtricuspid, and right ventricular mass and in a severe clinical state. Multimodal imaging raised the suspicion of primary cardiac angiosarcoma. Due to rapid hemodynamic and respiratory deterioration, we were forced to perform surgical removal of the mass with a concomitant reconstruction of the involved right heart structures, only 48 h after presentation. The postoperative course was uneventful, and the patient was discharged from the intensive care unit 2 days later. Radical surgical resection with reconstruction of the resected heart structures was the only possible salvage option for giant angiosarcoma, which led to hemodynamic instability. Followed by chemotherapy, this radical approach may prolong survival.
Serotonin reuptake inhibitor and fluvoxamine-induced severe hyponatremia in a 49-year-old man
Authors: Adel Gabriel
Journal: Case Rep Med (2009)
MeSH terms: Case Reports

Objectives. To describe a case of fluvoxamine-induced severe hyponatremia, most likely due to abnormal antidiuretic hormone excretion (SIADH), and to discuss the implication for maintenance treatments for these patients. Clinical Observations. Although this syndrome had its incidence most commonly among the elderly, we report a case of severe hyponatremia (serum sodium <114 mmol/L), in a relatively young male. Treatment. Symptoms responded well to IV hyperosmolar sodium and to the discontinuation of fluvoxamine. This patient was maintained for treatment on an alternative Selective Serotonin Reuptake Inhibitor (SSRI), Citalopram, without developing recurrence of symptoms. Outcome and Conclusion. Protocols to monitor the maintenance treatments in high-risk patients may be needed to prevent recurrence of serious complications.
Genome analysis revealed novel genotypes and recombination of the human parechoviruses prevalent in children in Eastern China
Authors: Xiangyang Zhao, Yongqiang Shi, Yu Xia
Journal: Gut Pathog (2016)
Keywords: genome sequence, human parechovirus, phylogenetic analysis, recombination
MeSH terms: Case Reports

Background:
Human parechovirus (HPeV) is a genus of virus in the family Picornaviridae, having two species A and B. HPeVs are common infectious agents, usually causing mild diarrhea and respiratory disease in young children.
Results:
Here, we collected and sequenced the near complete genome sequences of 17 novel HPeVs from children with diarrhea in eastern China, which showed significant nucleotide sequence divergence. Phylogenetic analysis based on the complete genomes of these HPeV strains revealed that they belonged to seven different genotypes (including three putative novel genotypes), suggesting that HPeVs showed genotype diversity in this area. Recombination analysis indicated that one of the HPeVs, belonging to HPeV-1 with strain name 146Chzj02, was a recombinant generated by inter-genotype recombination among three HPeV strains belonging to three different genotypes, respectively.
Conclusion:
Our data revealed the property of the genotype diversity of HPeVs prevalent in children with diarrhea in eastern China, which will be helpful in the future study of the viral evolution of HPeVs and the identification and typing of HPeVs in the clinical laboratory.
Endocrown: An Alternative Approach for Restoring Endodontically Treated Molars with Large Coronal Destruction
Authors: Houda Dogui, Feriel Abdelmalek, Adel Amor, Nabiha Douki
Journal: Case Rep Dent (2018)
MeSH terms: Case Reports

Rehabilitation of endodontically treated molar still remains a challenge. After endodontic treatment, molars lost their mechanical characteristics. In fact, they became fragile and that is in relation with the removal of pulp and surrounding dentin tissues. Endocrown which is a single partial restoration could be considered as a good alternative for restoring molars having large coronal destruction and presenting endodontic treatment difficulties. Through this work, we discuss the indication and use of endocrown to replace single crowns with intraradicular retention and to present a clinical case report of an endocrown-type restoration, fabricated from lithium disilicate ceramic (IPS e.Max CAD) in a mandibular first molar with extensive coronal destruction.
Iatrogenic colorectal Kaposi sarcoma complicating a refractory ulcerative colitis in a human immunodeficiency negative-virus patient
Authors: Lamine Hamzaoui, Houda Kilani, Mahdi Bouassida, Moufida Mahmoudi, Emna Chalbi, Karima Siai, Heykel Ezzine, Hassen Touinsi, Mohamed M'saddak Azzouz, Sadok Sassi
Journal: Pan Afr Med J (2013)
Keywords: human herpes virus-8, infliximab, kaposi's sarcoma, immunosuppression, ulcerative colitis
MeSH terms: Colitis, Ulcerative / complications, Colorectal Neoplasms / complications, Sarcoma, Kaposi / complications, Case Reports, Adult, Antibodies, Monoclonal / administration & dosage, Azathioprine / administration & dosage, Colitis, Ulcerative / drug therapy, Colitis, Ulcerative / surgery, Colorectal Neoplasms / diagnosis, Colorectal Neoplasms / surgery, HIV Seronegativity, Humans, Iatrogenic Disease, Infliximab, Male, Sarcoma, Kaposi / diagnosis, Sarcoma, Kaposi / surgery, Steroids / administration & dosage, Treatment Failure, Antibodies, Monoclonal, Steroids, Infliximab, Azathioprine

Kaposi sarcoma is a mesenchymal tumor associated to a human herpes virus-8. It often occurs in human immunodeficiency virus-positive subjects. Colorectal localization is rare. We report the case of a colorectal Kaposi sarcoma complicating a refractory ulcerative colitis treated with surgery after the failure of immunomodulator therapy in a human immunodeficiency virus-negative heterosexual man.
Case report: Treatment of intraductal papillary mucinous neoplasms located in middle-segment pancreas with end-to-end anastomosis reconstruction after laparoscopic central pancreatectomy surgery through a pigtail-tube-stent placement of the pancreatic duct
Authors: Guohua Liu, Xiaoyu Tan, Jiaxing Li, Guohui Zhong, Jingwei Zhai, Mingyi Li
Journal: Front Surg (2022)
Keywords: anastomosis, case report, intraductal papillary mucinous neoplasm (ipmn), laparoscopic, pancreatectomy
MeSH terms: Case Reports

Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is one type of pancreatic cystic neoplasm. IPMNs can be classified into three types: main duct-IPMN (MD-IPMN), branch duct-IPMN (BD-IPMN), and mixed type-IPMN (MT-IPMN). It is universally accepted by most surgeons that patients who suffered from MD-IPMN with a high risk of malignant transformation should undergo surgical resection. However, a consensus on the best surgical strategy for MD-IPMN located in the pancreatic neck has still eluded the surgical community worldwide. Recently, one patient suffering from this condition in our Minimally Invasive Pancreas Center underwent a successful surgical procedure. In this case report, we performed a laparoscopic central pancreatectomy for this patient. During this surgical procedure, we used a method of end-to-end anastomosis reconstruction through a pigtail-tube-stent placement of the pancreatic duct. Before the construction of the remnant pancreas, the surgical margins of the frozen section should be negative. After surgery, the outcome of this case was satisfactory. No complications such as postoperative hemorrhage, abdominal infection, pancreatitis, delayed gastric emptying, and clinically relevant postoperative pancreatic fistula occurred, which demonstrated that this surgical strategy could achieve a good clinical therapeutic effect for the pancreatic neck MD-IPMN. The result of postoperative routine pathology confirmed the diagnosis of MD-IPMN. The pathological features also showed that there was a high degree of hyperplasia in the local epithelium, which indicated the necessity of surgical treatment.