OpenMed/multicare-articles huggingface dataset:
Rare presentation of chronic ileocecal intussusception secondary to Burkitt's lymphoma in three years Sudanese boy: a case report and literature review
Authors: Atif Ahmed Mohamed Saad, Tasnim Kkalid, Mohammed Abbas, Karimeldin Mohammed Ali Salih
Journal: Pan Afr Med J (2018)
Keywords: burkett´s lymphoma, intussusception, sudan
MeSH terms: Burkitt Lymphoma / diagnosis, Cecal Diseases / diagnosis, Ileal Diseases / diagnosis, Intussusception / etiology, Case Reports, Review, Burkitt Lymphoma / complications, Cecal Diseases / etiology, Cecal Diseases / surgery, Child, Preschool, Chronic Disease, Humans, Ileal Diseases / etiology, Ileal Diseases / surgery, Intussusception / diagnosis, Intussusception / surgery, Laparotomy / methods, Male, Sudan

A case report of chronic ileocecal intussusceptions in 3-years old Sudanese boy diagnosed as abdominal Burkett's lymphoma as leading point, who presented to his local hospital severely wasted with prolonged abdominal symptoms. Ultra sound and computed tomographic scan of his abdomen and pelvis with oral contrast confirmed intussusception. He was referred to pediatric surgical department and underwent laparotomy confirming ileocecal intussusception with resection of gangrenous part of his large and small bowel with end-to-end anastomosis. Histopathology of resected part showed infiltration of small bowel with cells of Burkett's lymphoma. This case highlights the importance of considering chronic intussusception, though rare, as a cause of faltering growth in young children with prolonged abdominal symptoms. The multidisplinary approach was highly appreciated and the outcome was satisfactory.
Long-term outcomes of coracoid bone block osteolysis: case report
Authors: Arthur Floquet, Steven Roulet, Luc Favard
Journal: Pan Afr Med J (2022)
Keywords: latarjet procedure, case report, complication, osteolysis
MeSH terms: Joint Instability / surgery, Osteolysis / etiology, Osteolysis / surgery, Shoulder Joint / surgery, Case Reports, Arthroplasty, Humans, Scapula / surgery

Latarjet procedure is reliable and reproductible procedure for treatment of anterior shoulder instability. Results are durable but complications can occur: neurological injury, non-union, infection, stiffness, osteolysis of coracoid bone block, recurrence of dislocation, osteoarthritis. We present the case of two patients with complication not described in the literature: osteolysis of the neck of the scapula around screws discovered at 8 and 20 years after initial surgery. These patients presented with previous pain which motivated consultation. Imaging showed coracoid bone block osteolysis, extensive geode weakening articular surface of scapular glenoid, around screws which are not bi-cortical. Screws were removed, osteolysis was filled with iliac cancellous bone graft and joint capsule was re-tensioned. Results of this procedure at one year were clinical and radiological satisfactory.
Fetal cervical neuroblastoma: prenatal diagnosis
Authors: Ismail Güzelmansur, Hatice Tatar Aksoy, Sibel Hakverdi, Mustafa Seven, Uğur Dilmen, Gülçin Dilmen
Journal: Case Rep Med (2011)
MeSH terms: Case Reports

Neuroblastoma is the most frequent extracranial solid tumor in childhood, but it is seldom diagnosed prenatally. It usually presented with adrenal masses. Presentation of other localization is extremely rare. We report a case of cervical neuroblastoma identified at 20 weeks of gestational age. This is the third case diagnosed antenatally on neck region in the literature. Additionally, it is the first case that extended to the brain. We also discussed the literature for cervical neuroblastoma detected prenatally.
GABAB receptor ligands for the treatment of alcohol use disorder: preclinical and clinical evidence
Authors: Roberta Agabio, Giancarlo Colombo
Journal: Front Neurosci (2014)
Keywords: gabab receptor, alcohol use disorder, animal models of alcohol use disorder, baclofen, positive allosteric modulators
MeSH terms: Review

The present paper summarizes the preclinical and clinical studies conducted to define the "anti-alcohol" pharmacological profile of the prototypic GABAB receptor agonist, baclofen, and its therapeutic potential for treatment of alcohol use disorder (AUD). Numerous studies have reported baclofen-induced suppression of alcohol drinking (including relapse- and binge-like drinking) and alcohol reinforcing, motivational, stimulating, and rewarding properties in rodents and monkeys. The majority of clinical surveys conducted to date-including case reports, retrospective chart reviews, and randomized placebo-controlled studies-suggest the ability of baclofen to suppress alcohol consumption, craving for alcohol, and alcohol withdrawal symptomatology in alcohol-dependent patients. The recent identification of a positive allosteric modulatory binding site, together with the synthesis of in vivo effective ligands, represents a novel, and likely more favorable, option for pharmacological manipulations of the GABAB receptor. Accordingly, data collected to date suggest that positive allosteric modulators of the GABAB receptor reproduce several "anti-alcohol" effects of baclofen and display a higher therapeutic index (with larger separation-in terms of doses-between "anti-alcohol" effects and sedation).
Congenital cataracts in an Ayrshire herd: a herd case report
Authors: Lea Krump, Luke O'Grady, Ingrid Lorenz, Terence Grimes
Journal: Ir Vet J (2014)

An Ayrshire dairy herd was investigated for occurrence of ocular abnormalities in new-born calves. Ophthalmic examinations were performed on all the animals in the herd and 26% of them were diagnosed with bilateral cataracts. Cataracts varied in extent and severity but the majority were restricted to the lens nucleus. Epidemiological analysis showed the prevalence was higher in male animals and lower in animals born to heifers. A family tree was designed but no genetic impact of dam lines was evident. Sire data was incomplete and could therefore not be included. Based on the information provided by the farmer there was no obvious environmental or nutritional cause of these cataracts. However, data records were incomplete and further investigation/monitoring of the herd would be needed to establish a cause and enable a better insight into the aetiology of this disease in cattle.
Dexmedetomidine as Part of a Multimodal Analgesic Treatment Regimen for Opioid Induced Hyperalgesia in a Patient with Significant Opioid Tolerance
Authors: Richard K Patch Iii, Jason S Eldrige, Susan M Moeschler, Matthew J Pingree
Journal: Case Rep Anesthesiol (2017)
MeSH terms: Case Reports

Acute postoperative pain in patients with opioid tolerance creates a significant management challenge for anesthesiologists and pain medicine physicians. A multimodal approach is key; however other factors can complicate management such as opioid induced hyperalgesia. We present the case of a patient on large amounts of intrathecal opioids for chronic pain syndrome with opioid induced hyperalgesia after an exploratory laparotomy. Dexmedetomidine was utilized successfully as part of a controlled multimodal analgesic plan and should be a consideration for opioid tolerant patients experiencing opioid induced hyperalgesia.
Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency
Authors: Tarana Singh Dang, Joseph D P Willet, Helen R Griffin, Neil V Morgan, Graeme O'Boyle, Peter D Arkwright, Stephen M Hughes, Mario Abinun, Louise J Tee, Dawn Barge, Karin R Engelhardt, Michael Jackson, Andrew J Cant, Eamonn R Maher, Mauro Santibanez Koref, Louise N Reynard, Simi Ali, Sophie Hambleton
Journal: J Clin Immunol (2016)
Keywords: cd4 lymphopenia, combined immunodeficiency, mst1, stk4, chemotaxis, lymphocyte adhesion
MeSH terms: Cell Adhesion / genetics, Chemotaxis, Leukocyte / genetics, Genes, Recessive, Immunologic Deficiency Syndromes / diagnosis, Immunologic Deficiency Syndromes / genetics, Protein Serine-Threonine Kinases / deficiency, Case Reports, Child, Preschool, Female, Humans, Immunologic Deficiency Syndromes / metabolism, Immunophenotyping, Intercellular Adhesion Molecule-1 / metabolism, Intracellular Signaling Peptides and Proteins, Lymphocytes / immunology, Lymphocytes / metabolism, Pedigree, Phenotype, Siblings, Intracellular Signaling Peptides and Proteins, Intercellular Adhesion Molecule-1, STK4 protein, human, Protein Serine-Threonine Kinases

Purpose:
To investigate the clinical and functional aspects of MST1 (STK4) deficiency in a profoundly CD4-lymphopenic kindred with a novel homozygous nonsense mutation in STK4. Although recent studies have described the cellular effects of murine Mst1 deficiency, the phenotype of MST1-deficient human lymphocytes has yet to be fully explored. Patient lymphocytes were therefore investigated in the context of current knowledge of murine Mst1 deficiency.
Methods:
Genetic etiology was identified by whole exome sequencing of genomic DNA from two siblings, combined with linkage analysis in the wider family. MST1 protein expression was assessed by immunoblotting. The ability of patient lymphocytes to adhere to ICAM-1 under flow conditions was measured, and transwell assays were used to assess chemotaxis. Chemokine receptor expression was examined by flow cytometry and receptor signalling by immunoblotting.
Results:
A homozygous nonsense mutation in STK4 (c.442C > T, p.Arg148Stop) was found in the patients, leading to a lack of MST1 protein expression. Patient leukocytes exhibited deficient chemotaxis after stimulation with CXCL11, despite preserved expression of CXCR3. Patient lymphocytes were also unable to bind effectively to immobilised ICAM-1 under flow conditions, in keeping with a failure to develop high affinity binding.
Conclusion:
The observed abnormalities of adhesion and migration imply a profound trafficking defect among human MST1-deficient lymphocytes. By analogy with murine Mst1 deficiency and other defects of leucocyte trafficking, this is likely to contribute to immunodeficiency by impairing key aspects of T-cell development and function such as positive selection in the thymus, thymic egress and immune synapse formation in the periphery.
Late respiratory alkalosis during home mechanical ventilation in amyotrophic lateral sclerosis
Authors: M M García, J M Díaz, A Antón
Journal: Respir Med Case Rep (2023)
MeSH terms: Case Reports

This demonstrative case report shows how changes in the patient's ventilatory pattern can radically modify the results of home noninvasive mechanical ventilation, and can even generate complications associated with noninvasive ventilation such as ventilatory alkalosis.
Sacral Stress Fracture in an Amateur Badminton Player
Authors: Yusuke Yuasa, Naohisa Miyakoshi, Michio Hongo, Kunio Ebata, Tatsuru Tomioka, Yoichi Shimada
Journal: Case Rep Orthop (2017)
MeSH terms: Case Reports

Sacral stress fractures are rare among athletes but have been reported most frequently in long distance runners. We report herein the first case of a sacral stress fracture in an amateur badminton player. A 16-year-old, left-handed adolescent girl, who had just started to play badminton 3 months previously, complained of acute left buttock pain when she received a shuttlecock. Magnetic resonance imaging revealed a linear lesion of the left sacrum with low signal intensity on T1- and high signal intensity on T2-weighted images, which was consistent with a stress fracture. Conservative treatment with rest relieved her symptoms. Her fracture was considered to have occurred due to repetition of an exercise that caused excessive vertical power.
Subcutaneous Emphysema as a Complication of Tonsillectomy: A Systematic Literature Review and Case Report
Authors: Panagiotis Saravakos, Margaritis Taxeidis, Ioannis Kastanioudakis, Oliver Reichel
Journal: Iran J Otorhinolaryngol (2018)
Keywords: mediastinal emphysema, subcutaneous emphysema, tonsillectomy
MeSH terms: Review

Introduction:
Subcutaneous and mediastinal emphysema is a rare complication after tonsillectomy. This case presentation and literature review summarizes the existing literature on this unusual complication.
Materials and methods:
This study presents a case of a 21-year-old man who developed a cervical subcutaneous emphysema 6 days after tonsillectomy, whereby conservative treatment produced spontaneous resolution. A proper analysis of this case also required undertaking a systematic search in MEDLINE/PubMed and SCOPUS electronic databases concerning this rare complication, without language restrictions.
Results:
Based on our criteria, we identified 41 reports including 43 individual cases, in which patients were mostly young and equally distributed between the genders (18 males and 23 females, two unknown). The treatment was mainly conservative and consisted of observation and/or antibiotic therapy.
Conclusion:
Subcutaneous or mediastinal emphysema is an uncommon complication after tonsillectomy. It is important that clinicians become aware of this rare complication, which requires a close monitoring of the patient.
Mesenchymal Stem Cells May Ameliorate Nephrotic Syndrome Post-Allogeneic Hematopoietic Stem Cell Transplantation-Case Report
Authors: Xin Zhang, Yanwen Peng, Zhiping Fan, Ke Zhao, Xiaoyong Chen, Ren Lin, Jing Sun, Guobao Wang, AndyPeng Xiang, Qifa Liu
Journal: Front Immunol (2017)
Keywords: allogeneic hematopoietic stem cell transplantation, chronic graft-versus-host disease, mesenchymal stem cells, nephrotic syndrome, regulatory b cell

Introduction:
Because of their immunomodulatory and anti-inflammatory effects, mesenchymal stem cells (MSCs) have been considered as potential therapeutic agents for treating immune-related or autoimmune diseases, such as graft-versus-host disease (GVHD). Nephrotic syndrome (NS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an uncommon complication with unclear etiology and pathogenesis. It may be an immune disorder involving immune complex deposition, B cells, regulatory T cells (Tregs), and Th1 cytokines and be a manifestation of chronic GVHD. Corticosteroids and calcium antagonists, alone or in combination, are the most common therapeutic agents in this setting. Rituximab is commonly administered as salvage treatment. However, treatment failure and progressive renal function deterioration has been reported to occur in approximately 20% of patients in a particular cohort.
Case presentation:
We present a patient who developed NS 10 months after allo-HSCT. After treatment failure with cyclosporine A, prednisone, and rituximab, she achieved a complete response with MSC treatment. The clinical improvement of this patient was accompanied by a decreased B cell population together with an increased frequency of regulatory B cells (Bregs) and Tregs after MSC treatment.
Conclusion:
MSCs could modulate NS after allo-HSCT by suppressing B cell proliferation, inducing Tregs and Bregs, and inhibiting inflammatory cytokine production by monocytes and NK cells. Among all these, Bregs might play an important role in ameliorating the NS of this patient.
Nephrogenic Adenoma of the Urinary Bladder after Kidney Transplantation: Long-Term Follow-Up
Authors: Iftikhar Khan, Mahmoud Obeid, Nasreen Hasan, Fayyad Jaradat, Bodhisatwa Sengupta, Mahmoud Tabbal, Abdullah Alsaif, Mansour Tawfeeq, Mohammad Al Qahtani
Journal: Case Rep Transplant (2020)
MeSH terms: Case Reports

Nephrogenic adenoma is a rare lesion that consists of epithelial cells arranged in tubular form, resembling tubules in the renal medulla, and is found usually in the urinary bladder although it can occur anywhere in the transitional epithelium of the lower urinary tract. The first case of nephrogenic adenoma of the urinary bladder was reported before the first kidney transplantation, and the lesion has been reported in patients with and without renal transplantation. The origin of cells in nephrogenic adenoma is debated and has been postulated to arise from cells of embryonic origin or from metaplasia secondary to chronic irritation or from implantation of allograft cells in patients with kidney transplantation. The long-term outcome and potential to convert into malignancy are not established, and therefore, there are no recommendations on how to follow up these patients. We present a case of a patient who was found to have nephrogenic adenoma of the urinary bladder during his second kidney transplantation from a cadaveric donor. He had undergone living donor kidney transplantation previously which subsequently failed. The patient did not manifest any symptoms of nephrogenic adenoma. During a follow-up period of 5 years, he has not manifested any symptoms related to nephrogenic metaplasia. Histopathological examination 5 years after the second transplantation did not show any malignant change. It can be concluded that nephrogenic adenoma is likely to behave in benign fashion post kidney transplantation.
Interrupted inferior vena cava combined with partial anomalous pulmonary venous return drainage to the IVC in a 67-year-old adult
Authors: Hee Jae Jun
Journal: J Card Surg (2013)
MeSH terms: Blood Vessel Prosthesis Implantation / methods, Scimitar Syndrome / surgery, Vena Cava, Inferior / abnormalities, Vena Cava, Inferior / surgery, Case Reports, Aged, Female, Humans, Kidney / blood supply, Polytetrafluoroethylene, Thoracotomy, Polytetrafluoroethylene

A 67-year-old woman presented with lower body edema and was found to have a suprarenal inferior vena cava (IVC) obstruction without hepatic vein obstruction and partial anomalous pulmonary venous return (PAPVR) draining the right pulmonary veins to the IVC below the obstructed IVC on CT angiography. The patient underwent retrohepatic cavoatrial bypass with a polytetrafluoroethylene (PTFE) 16-mm ringed graft via a posterolateral thoracotomy and retroperitoneal approach.
The Auscultation of a Carbon Dioxide Embolization Event during Endoscopic Vein Harvest
Authors: Erik Strauss, Bradley Taylor, Michael Mazzeffi, Kenichi Tanaka, Patrick Odonkor
Journal: Case Rep Anesthesiol (2016)

Endoscopic vein harvest in preparation for coronary artery bypass surgery has become a preferred method of procuring saphenous vein. Several case reports have documented carbon dioxide (CO2) embolization with this procedure as well as CO2 embolization during other laparoscopic surgeries (Markar et al., 2010). Although uncommon, the potential for CO2 entrainment through an open vein or through absorption by vascular structures exists and should be recognized (Lin et al., 2003). We report a case of CO2 embolization during EVH for a 77-year-old patient who underwent CABG that was identified early by the cardiac surgeon through the indirect auscultation of a mill-wheel murmur after the pericardium was opened. This may be the first reported case of a murmur related to air emboli identified without the use of a precordial Doppler probe or a stethoscope. This diagnosis was further supported by TEE before systemic hypotension or cardiovascular collapse occurred.
A rare case of Pseudomonas putida ventriculitis in intensive care unit: A case report
Authors: Mohammad Nizam Mokhtar, Izzuddin Azaharuddin, Farah Hanim Abdullah, Azarinah Izaham, Raha Abdul Rahman
Journal: Front Med (Lausanne) (2022)
Keywords: pseudomonas putida, external ventricular drain (evd), meningitis, nosocomial infection, ventriculitis
MeSH terms: Case Reports

Pseudomonas putida is a rare pathogen leading to nosocomial and central nervous system infections. Despite having a low virulence and being a rare organism to cause bacteremia, it can evolve into a multidrug-resistant organism and lead to mortality and morbidity in the intensive care setting. A 64-year-old male gardener was presented with extensive acute subarachnoid hemorrhage with intraventricular extension causing hydrocephalus requiring embolization and coiling following a cerebral angiogram, which showed bilateral posterior circulation aneurysm and left anterior circulation aneurysm. External ventricular drain (EVD) was inserted given the worsening hydrocephalus. During his stay in the intensive care unit (ICU), he was becoming more septic and a full septic workup including a cerebral spinal fluid culture taken from the indwelling catheter of the EVD and was found to be positive for a ceftazidime-sensitive strain of P. putida. Following the treatment with intravenous ceftazidime for 1 week and a revision of the EVD on day 32 of admission, he continued to recover well and showed an improvement in his Glasgow Coma Scale (GCS) and septic parameters. Eventually, he was able to wean off mechanical ventilation. He was discharged from ICU care to the neurosurgical ward with supplemental oxygen on day 42 of admission. It is necessary to be aware of the possibility of nosocomial P. putida infection, especially in patients with indwelling catheters, and to consider the early initiation of appropriate antibiotic regimens once detected as well as strict precautions in hygiene during the management of these patients to avoid further development of multi-drug resistant (MDR) strains.
Biliary peritonitis due to "fallen" hydatid cyst after abdominal trauma
Authors: Melih Kara, Deniz Tihan, Tuba Fersahoglu, Faruk Cavda, Izzet Titiz
Journal: J Emerg Trauma Shock (2008)
Keywords: biliary peritonitis, trauma, “fallen” hydatid cyst
MeSH terms: Case Reports

Hepatic hydatid cysts may cause serious complications. Intraperitoneal rupture of hepatic hydatid cyst is rarely seen and the prognosis can be fatal. By experience, we know that it might be difficult to diagnose an unruptured cyst expulsed into the peritoneal cavity. In this report, we present the case of a 54-year-old man with an intraperitoneal cystic mass of 10 cm of diameter which had extruded out from the liver due to a blunt abdominal trauma.
Myasthenia Gravis With Thymoma, Manifesting as AChR-Ab-Positive, Distinct Bulbar Palsy Accompanied by Dysgeusia: A Case Series and Review of Literature
Authors: Kai Zhu, Jiaxin Chen, Jingjing Li, Haiyan Wang, Xin Huang, Yan Li, Huiyu Feng
Journal: Front Neurol (2018)
Keywords: antibody positive, bulbar palsy, dysgeusia, myasthenia gravis, thymoma
MeSH terms: Case Reports

In this review, we summarized three cases of myasthenia gravis (MG) with taste disorder and describe their clinical features in detail. Three MG patients presented with significant bulbar palsy symptoms, high AChR-Ab titers, and negative MuSK-Ab, were diagnosed with thymoma. Furthermore, we observed that dysgeusia could manifest earlier than the occurrence of typical MG symptoms, even predict a MG relapse or a myasthenic crisis in the course of MG. We believe that dysgeusia is a non-motor symptom of MG, which especially exists in MG patients with thymoma and serious bulbar palsy. Therefore, being alert to this symptom may facilitate the early diagnosis of MG and judge the progress of the disease.
Influenceable and Avoidable Risk Factors for Systemic Air Embolism due to Percutaneous CT-Guided Lung Biopsy: Patient Positioning and Coaxial Biopsy Technique-Case Report, Systematic Literature Review, and a Technical Note
Authors: Gernot Rott, Frieder Boecker
Journal: Radiol Res Pract (2014)
MeSH terms: Review

Following the first case of a systemic air embolism due to percutaneous CT-guided lung biopsy in our clinic we analysed the literature regarding this matter in view of influenceable or avoidable risk factors. A systematic review of literature reporting cases of systemic air embolism due to CT-guided lung biopsy was performed to find out whether prone positioning might be a risk factor regarding this issue. In addition, a technical note concerning coaxial biopsy practice is presented. Prone position seems to have relevance for the development and/or clinical manifestation of air embolism due to CT-guided lung biopsy and should be considered a risk factor, at least as far as lesions in the lower parts of the lung are concerned. Biopsies of small or cavitary lesions in coaxial technique should be performed using a hemostatic valve.