OpenMed/multicare-articles huggingface dataset:
Octreotide Use in a Patient with MEN-1 Syndrome and Multifocal Pancreatic Neuroendocrine Tumors: A Case Report and Review of the Literature
Authors: Matthew H Kemm, Cory D Manly, Thanh D Hoang, Vinh Q Mai, Mohamed K M Shakir
Journal: Case Rep Gastrointest Med (2019)
MeSH terms: Case Reports

We report a patient with multiple endocrine neoplasia type 1 with pancreatic polypeptide (PP) secreting subcentimeter pancreatic neuroendocrine tumors (pNETs) treated with octreotide and review the current literature that pertains to the management of these patients. Clinical data, laboratory results, and imaging were reviewed. A literature search was performed in PUBMED using combinations of the terms "multiple endocrine neoplasia type 1," "somatostatin," octreotide," "pancreatic polypeptide," and "pancreatic tumor." Relevant references were selected and reviewed. A 43-year-old male with a history of MEN1 and multiple subcentimeter neuroendocrine tumors with elevation of PP was treated with octreotide therapy leading to a reduction and normalization of PP levels. The patient tolerated octreotide therapy but self-discontinued octreotide after 24 months with a rise in PP levels off therapy. Tumors remained stable in size through 40 months of imaging follow-up. In patients with MEN1 and subcentimeter pNETs, octreotide therapy is well tolerated and can lead to a significant drop in PP levels with no change in lesion size. There is insufficient data to suggest long-term benefit with octreotide therapy but it may be considered versus standard conservative management.
Treatment Strategy of Metastatic Nasopharyngeal Carcinoma With Bone Marrow Involvement-A Case Report
Authors: Bicheng Zhang, Ting Zhang, Lan Jin, Yan Zhang, Qichun Wei
Journal: Front Oncol (2022)
Keywords: bone marrow involvement, cetuximab, long-term survival, nasopahryngeal carcinoma, patient-derived tumor xenograft (pdtx)
MeSH terms: Case Reports

Bone marrow involvement (BMI) of solid tumors is a special type of distant metastasis. It has an occult onset, atypical clinical and laboratory features, and a high mortality. We present a nasopharyngeal carcinoma case with cervical and axillary lymph nodes, bilateral lung, multiple bone, and bone marrow metastases, who was treated chemotherapy plus targeted therapy under the guidance of a patient-derived tumor xenograft (PDTX) model, followed by maintenance chemotherapy plus immunotherapy. The patient's symptoms were relieved after four cycles of chemotherapy plus targeted therapy. His bone marrow biopsy turned negative after 7 months of therapy. In addition, his total peripheral T cells as well as the proportion of CD8+ T cells increased during the course of therapy. The combination of chemotherapy, targeted therapy, and immunotherapy provides an effective antitumor regimen for advanced NPC patients with BMI.
Omalizumab for Urticarial Vasculitis: Case Report and Review of the Literature
Authors: Misbah Nasheela Ghazanfar, Simon Francis Thomsen
Journal: Case Rep Dermatol Med (2015)

Urticarial vasculitis is characterised by inflamed itching or burning red patches or wheals that resemble urticaria but persist for greater than 24 hours. It is often idiopathic but is sometimes associated with collagen-vascular disease, particularly systemic lupus erythematosus. Treatment options include oral antihistamines, oral corticosteroids, dapsone, colchicine or hydroxychloroquine. We describe a male patient with urticarial vasculitis who was treated with omalizumab (anti-IgE) with convincing results and provide a review of previous reports of patients with urticarial vasculitis treated with omalizumab.
Ovarian Strumal Carcinoid: Case Report, Systematic Literature Review and Pooled Analysis
Authors: Antonella Turla, Manuel Zamparini, Massimo Milione, Salvatore Grisanti, Vito Amoroso, Rebecca Pedersini, Deborah Cosentini, Alfredo Berruti
Journal: Front Endocrinol (Lausanne) (2022)
Keywords: constipation, neuroendocrine tumors, ovarian strumal carcinoid, peptide yy, teratomas
MeSH terms: Carcinoid Tumor / diagnosis, Carcinoid Tumor / surgery, Ovarian Neoplasms / diagnosis, Ovarian Neoplasms / pathology, Ovarian Neoplasms / surgery, Struma Ovarii / diagnosis, Struma Ovarii / pathology, Struma Ovarii / surgery, Case Reports, Systematic Review, Research Support, Non-U.S. Gov't, Female, Humans, Neoplasm Recurrence, Local / surgery

Background:
Ovarian strumal carcinoid is a rare tumor in which thyroid (struma) and carcinoid components coexist. The disease is generally considered to be a borderline malignancy, however, cases with metastatic disease have been described. No data in the literature are available to guide diagnosis and therapy.
Methods:
We performed a pooled analysis and a systematic review of histopathological-confirmed strumal carcinoid cases published in the literature using the following keywords: "strumal carcinoid of the ovary", "strumal carcinoid case report". A case of strumal carcinoid tumor diagnosed and followed-up at the Medical Oncology Unit of Spedali Civili (Brescia, Italy) was also described and included.
Results:
Sixty-six eligible publications were identified, providing data from one hundred and seventeen patients, plus a case diagnosed at our institution. At presentation, among the eighty-eight patients with symptomatic disease, 37% of patients suffered from abdominal distention and 49% from pain due to a growing abdominal tumor mass, 37% from constipation (peptide YY was analyzed in only nine of them, resulting above the physiologic range). Surgery was the primary therapy in 99% of the patients. Three patients had metastatic disease at diagnosis and five patients underwent recurrence after radical surgery. Histology at disease recurrence concerned the thyroid component in two patients, the carcinoid component in two patients, both histologies in one patient. Median disease-free survival and overall survival in this series were not attained.
Conclusion:
Strumal carcinoid of the ovary generally presents a benign behavior and surgery is curative in most cases. However, a small group of patients with this disease can undergo disease recurrence due to both the thyroid and the neuroendocrine (carcinoid) components. A follow-up in radically operated patients is therefore needed, particularly in those with a voluminous disease at diagnosis.
A Case of Fracture-Redislocation of the Hip Caused by a Depressed Fracture of the Femoral Head Similar to a Hill-Sachs Lesion
Authors: Yoshihiko Okudera, Hiroaki Kijima, Shin Yamada, Natsuo Konishi, Hitoshi Kubota, Hiroshi Tazawa, Takayuki Tani, Norio Suzuki, Keiji Kamo, Ken Sasaki, Tetsuya Kawano, Yosuke Iwamoto, Naohisa Miyakoshi, Yoichi Shimada
Journal: Case Rep Orthop (2017)
MeSH terms: Case Reports

The present case shows a case of fracture-redislocation of the hip caused by a depressed fracture of the femoral head similar to a Hill-Sachs lesion. A 59-year-old man fell from a roof and his left hip joint was dislocated posteriorly. He was admitted to a nearby hospital, and he was referred to our hospital more than 24 hours after injury. Computed tomography (CT) suggested a bone chip from the posterior wall of the acetabulum roof and a depressed femoral head that cut into the posterior margin of the acetabulum roof. Immediate manual repositioning was performed under general anesthesia on the same day. He left our hospital to go home on day 26 after repositioning, but his left hip joint was dislocated again when he went down the stairs. It was thought that this patient's redislocation occurred due to a femoral head depressed fracture involving the same mechanism as the Hill-Sachs injury seen with dislocation of the shoulder. The remplissage method for the Hill-Sachs injury is difficult for the femoral head. Therefore, total hip replacement was performed, and the patient's postoperative course was good. We conclude that total hip arthroplasty should be considered as one of the best treatment methods for such cases.
Consolidated bioprocessing of Populus using Clostridium (Ruminiclostridium) thermocellum: a case study on the impact of lignin composition and structure
Authors: Alexandru Dumitrache, Hannah Akinosho, Miguel Rodriguez Jr, Xianzhi Meng, Chang Geun Yoo, Jace Natzke, Nancy L Engle, Robert W Sykes, Timothy J Tschaplinski, Wellington Muchero, Arthur J Ragauskas, Brian H Davison, Steven D Brown
Journal: Biotechnol Biofuels (2016)
Keywords: clostridium thermocellum, consolidated bioprocessing, guaiacyl, lignin, molecular weight, populus, s/g ratio, syringyl

Background:
Higher ratios of syringyl-to-guaiacyl (S/G) lignin components of Populus were shown to improve sugar release by enzymatic hydrolysis using commercial blends. Cellulolytic microbes are often robust biomass hydrolyzers and may offer cost advantages; however, it is unknown whether their activity can also be significantly influenced by the ratio of different monolignol types in Populus biomass. Hydrolysis and fermentation of autoclaved, but otherwise not pretreated Populus trichocarpa by Clostridium thermocellum ATCC 27405 was compared using feedstocks that had similar carbohydrate and total lignin contents but differed in S/G ratios.
Results:
Populus with an S/G ratio of 2.1 was converted more rapidly and to a greater extent compared to similar biomass that had a ratio of 1.2. For either microbes or commercial enzymes, an approximate 50 % relative difference in total solids solubilization was measured for both biomasses, which suggests that the differences and limitations in the microbial breakdown of lignocellulose may be largely from the enzymatic hydrolytic process. Surprisingly, the reduction in glucan content per gram solid in the residual microbially processed biomass was similar (17-18 %) irrespective of S/G ratio, pointing to a similar mechanism of solubilization that proceeded at different rates. Fermentation metabolome testing did not reveal the release of known biomass-derived alcohol and aldehyde inhibitors that could explain observed differences in microbial hydrolytic activity. Biomass-derived p-hydroxybenzoic acid was up to nine-fold higher in low S/G ratio biomass fermentations, but was not found to be inhibitory in subsequent test fermentations. Cellulose crystallinity and degree of polymerization did not vary between Populus lines and had minor changes after fermentation. However, lignin molecular weights and cellulose accessibility determined by Simons' staining were positively correlated to the S/G content.
Conclusions:
Higher S/G ratios in Populus biomass lead to longer and more linear lignin chains and greater access to surface cellulosic content by microbe-bound enzymatic complexes. Substrate access limitation is suggested as a primary bottleneck in solubilization of minimally processed Populus, which has important implications for microbial deconstruction of lignocellulose biomass. Our findings will allow others to examine different Populus lines and to test if similar observations are possible for other plant species.
Reconstruction With Pedicled Anterolateral Thigh Flap After Wide Local Excision of Penoscrotal Extramammary Paget's Disease: A Case Report and Comprehensive Literature Review
Authors: Cedric L Hunter, Eila C Skinner, Gordon K Lee
Journal: Eplasty (2015)
Keywords: anterolateral thigh flap, extramammary paget’s disease, penoscrotal reconstruction, wide local excision
MeSH terms: Review

Objective:
The clinical characteristics, management, and prognostic indicators of penoscrotal extramammary Paget's disease are not clearly defined. Surgical excision is often an effective treatment modality but results in a large wound after resection of all involved tissues.
Methods:
Reconstruction of large penoscrotal soft-tissue defects after wide local excision remains a challenge to the reconstructive surgeon. The use of the anterolateral thigh flap for penoscrotal reconstruction after resection of extramammary Paget's disease is infrequent as a reconstruction tool throughout the literature.
Results:
We discuss a case where the anterolateral thigh flap was effectively used for reconstruction of a large penoscrotal defect after wide local excision of penoscrotal extramammary Paget's disease and present a comprehensive literature review of extramammary Paget's disease key features, diagnosis, prognosis, and treatment.
Conclusions:
The anterolateral thigh flap is a useful tool for penoscrotal defect reconstruction.
Case report: Suicide and inhibitions of thinking-An integrative view from traditional psychoanalytic and mentalizing perspectives
Authors: Chong Seng Choi
Journal: Front Psychiatry (2023)
Keywords: core conflict, dysfunctional mental processing, inhibition of thinking, mentalizing, psychoanalysis, suicide
MeSH terms: Case Reports

Suicide has been the subject of exploration in psychoanalysis. From Freud's internalized aggression and self-objectification in melancholic depression to contributions from object relation and self-psychology theorists, several of these central clinical concepts seem to share the commonality that one encounters an inhibition of thinking in a suicidal state of mind. Their freedom of thought is inhibited unswervingly despite the notion that we are born to think. Most psychopathologies, including suicide, relate to how we are often stuck with our thoughts. Thinking beyond this sense comes with significant emotional resistance. This case report follows through an attempt to integrate the hypothesized inhibitions on one's capability to think, involving one's own core conflicts and dysfunctional mental processing from the traditional psychoanalytic and mentalizing perspectives. The author hopes that further conceptualizations and research will empirically investigate these assumptions, potentially improving suicide risk assessment and prevention and enhancing psychotherapeutic outcomes.
Diffuse Hepatic Hemangiomatosis with Giant Cavernous Hemangioma in an Adult
Authors: Olaia Chalh, Nabil Moatassim Billah, Ittimad Nassar
Journal: J Belg Soc Radiol (2022)
Keywords: mri, diffuse hemangiomatosis, giant hemangioma, liver
MeSH terms: Case Reports

Teaching Point: Although frequent, the coexistence of diffuse hepatic hemangiomatosis (DHH) with giant cavernous hemangioma (GCH) should be mentioned clearly and communicated to the referring physician for an appropriate management.
Atypical focal osteomyelitis as initial manifestation of AIDS
Authors: A Akiki, Y Bilde
Journal: Case Rep Orthop (2011)
MeSH terms: Case Reports

Persistent pain development after a skeletal contusion rarely poses the diagnosis of osteomyelitis. We report the case of a fibular head contusion as an initial manifestation of a focal abscess development in a healthy young patient. The traditional treatment of surgical drainage revealed the presence of an atypical Mycobacterium haemophilum isolates in the abscess. This lead to further investigations that concluded and established the diagnosis of AIDS. Conclusion. Isolation of an atypical Mycobacterium haemophilum in any abscess should lead the physician to accomplish further investigations and look for AIDS even in young healthy subjects.
Asymptomatic peritoneal carcinomatosis originating from benign cystic peritoneal mesothelioma
Authors: S Iacoponi, J Calleja, G Hernandez, R Sainz de la Cuesta
Journal: Ecancermedicalscience (2015)
Keywords: benign multicystic mesothelioma, carcinomatosis, ovarian cancer, peritoneal cancer
MeSH terms: Case Reports

Benign multicystic mesothelioma is a rare tumour that originates from the abdominal peritoneum with a predisposition to the pelvic peritoneum. It typically affects women of reproductive age. There have been less than 200 cases of this rare neoplasia reported to date. We present the case of a 35-year-old woman who was referred to our centre because of the detection of a peritoneal carcinomatosis during a gynaecological exam. A diagnostic laparoscopy was performed. The findings included multiple cysts appearing as 'a bunch of grapes' occupying the omentum. Biopsies were taken during the surgery and the results showed benign multicystic peritoneal mesothelioma. Benign multicystic mesothelioma can simulate other conditions, such as malignant ovarian tumours or cystic lymphangioma. It is often diagnosed accidentally during surgery performed for another reason. The diagnosis is interoperative, observing multicystic structures grouped as a 'bunch of grapes' containing clear fluid with thin walls made of connective tissue. Immunohistochemistry confirmed mesothelial origin. Surgery is considered the treatment of choice and is based on the removal of the cysts from the abdominal cavity. Hyperthermic intraperitoneal chemotherapy can be considered as a primary treatment in patients with recurrences or even as a part of primary treatment associated with surgery. Survival at 5 years is 100% and invasive or malignant progression is extraordinary. The treatment approach should be multidisciplinary, and the patient should be referred to a referral centre.
Case report: The origin of transmantle-like features
Authors: Takeshi Matsuo, So Fujimoto, Takashi Komori, Yasuhiro Nakata
Journal: Front Radiol (2022)
Keywords: corpora amylacea, focal cortical dysplasia, the radial-oriented white matter band, transmantle sign, tuberous sclerosis
MeSH terms: Case Reports

The transmantle sign is considered to be a magnetic resonance imaging feature specific to patients with type II focal cortical dysplasia; however, this sign can be difficult to distinguish from other pathologies, such as a radial-oriented white matter band in tuberous sclerosis. Here, we report a case showing a high-intensity area on T2-weighted and fluid-attenuated inversion recovery images extending from the ventricle to the cortex associated with atypical histopathological findings containing corpora amylacea. This case demonstrates that some instances of transmantle signs may be due to corpora amylacea accumulation.
Case report: Fourth branchial cleft cyst: a case of acute suppurative thyroiditis
Authors: M Eduarda Caseiro Alves, Ana Nunes, Júlia Galhardo
Journal: Front Pediatr (2023)
Keywords: congenital anomalies, fourth branchial cleft cyst, pediatrics, thyroid, thyroiditis
MeSH terms: Case Reports

This case report presents a 4 year-old-female patient with a neck mass who was diagnosed with an infected fourth branchial cleft cyst with left thyroid lobe involvement through fistulation. The case emphasizes the importance of considering uncommon etiologies, such as congenital anomalies, as a differential diagnosis when evaluating pediatric neck masses. The patient was prescribed broad-spectrum antibiotics, which led to the regression of the mass and inflammatory signs. Close follow-up in endocrinology and otorhinolaryngology appointments was maintained, and after 7 months, hypoplasia of the left lobe was observed. Thyroid function was reevaluated, and after two years, no recurrences were noted. The case highlights the significance of a comprehensive examination and assessment of corresponding clinical features, which can significantly reduce the rate of misdiagnoses and achieve an individualized diagnosis.
Takotsubo Cardiomyopathy in Dextrocardia with Situs Inversus
Authors: A Ganes, L Segan
Journal: Case Rep Cardiol (2020)
MeSH terms: Case Reports

Takotsubo cardiomyopathy (TTC) is an acute reversible form of left ventricular (LV) systolic dysfunction extending beyond a coronary artery vascular territory usually due to physical or psychological stressors. Dextrocardia with situs inversus is a rare embryologic anomaly whereby the heart and aorta are mirrored on the contralateral side. We describe a case of a 93-year-old female with dextrocardia who presented with chest pain, atrial fibrillation with rapid ventricular response, and transient inferior ST elevation. Coronary angiography demonstrated an eccentric mid right coronary artery (RCA) lesion and apical ballooning consistent with concurrent takotsubo cardiomyopathy (TTC). To our knowledge, this is the first reported case of this dual pathology in a patient with dextrocardia, highlighting the procedural and diagnostic complexity in the setting of a rare anatomicvariant.
Bent intramedullary femoral nail: surgical technique of removal and reconstruction
Authors: Vasileios I Sakellariou, Stamatis Kyriakopoulos, Helias Kotoulas, Ioannis P Sofianos
Journal: Case Rep Orthop (2011)
MeSH terms: Case Reports

A secondary high-velocity trauma to a previously stabilized femoral fracture with intramedullary nailing is rare. In this paper, we present the management of a 40-year-old man presented with a bent intramedullary nail due to secondary trauma. A lateral longitudinal femoral osteotomy was used for the resection of the distorted nail. The femur was reconstructed with a new nail, and the fixation of the osteotomy was achieved with plate and cerclage wires. Five months postrevision surgery, callus formation was evident and the patient regained a normal range of motion and gait, walking with a single cane.
Somatostatin Analogue Treatment of a TSH-Secreting Adenoma Presenting With Accelerated Bone Metabolism and a Pericardial Effusion: A Case Report
Authors: Athanasios C Mousiolis, Eleni Rapti, Maria Grammatiki, Maria Yavropoulou, Maria Efstathiou, Nikolaos Foroglou, Michalis Daniilidis, Kalliopi Kotsa
Journal: Medicine (Baltimore) (2016)
MeSH terms: Adenoma / therapy, Antineoplastic Agents, Hormonal / therapeutic use, Bone Diseases, Metabolic / etiology, Octreotide / therapeutic use, Pericardial Effusion / etiology, Pituitary Neoplasms / therapy, Case Reports, Adenoma / complications, Adenoma / metabolism, Adult, Humans, Male, Pituitary Neoplasms / complications, Pituitary Neoplasms / metabolism, Thyrotropin / metabolism, Antineoplastic Agents, Hormonal, Thyrotropin, Octreotide

Increased bone turnover and other less frequent comorbidities of hyperthyroidism, such as heart failure, have only rarely been reported in association with central hyperthyroidism due to a thyrotropin (TSH)-secreting pituitary adenoma (TSHoma). Treatment is highly empirical and relies on eliminating the tumor and the hyperthyroid state.We report here an unusual case of a 39-year-old man who was initially admitted for management of pleuritic chest pain and fever of unknown origin. Diagnostic work up confirmed pericarditis and pleural effusion both refractory to treatment. The patient had a previous history of persistently elevated levels of alkaline phosphatase (ALP), indicative of increased bone turnover. He had also initially been treated with thyroxine supplementation due to elevated TSH levels. During the diagnostic process a TSHoma was revealed. Thyroxine was discontinued, and resection of the pituitary tumor followed by treatment with a somatostatin analog led to complete recession of the effusions, normalization of ALP, and shrinkage of pituitary tumor.Accelerated bone metabolism and pericardial and pleural effusions attributed to a TSHoma may resolve after successful treatment of the tumor. The unexpected clinical course of this case highlights the need for careful long-term surveillance in patients with these rare pituitary adenomas.