OpenMed/multicare-articles huggingface dataset:
Acute myocardial infarction following intravenous tissue plasminogen activator for acute ischemic stroke: An unknown danger
Authors: Adatia Sweta, Sanghani Sejal, Sanzgiri Prakash, Chauhan Vinay, Hastak Shirish
Journal: Ann Indian Acad Neurol (2010)
Keywords: acute myocardial infarction, acute ischemic stroke, intravenous tissue plasminogen activator
MeSH terms: Case Reports

Thrombolysis with intravenous tissue (IV) plasminogen activator (tPA) is considered for patients with acute ischemic stroke falling within the described inclusion criteria defined by The National Institute of Neurological Disorders and Stroke (NINDS) rtPA trial. Complications of IV thrombolysis with tPA are commonly related to hemorrhage, anaphylaxis, or arterial occlusion. We describe two cases of acute myocardial infarction (MI) following IV tPA infusion for acute stroke. One of the patients had underlying ischemic heart disease (IHD) while the other did not have any prior IHD. Both had presented with acute ischemic stroke within the window period of thrombolysis and had no contraindications for thrombolysis. Both the patients succumbed due to myocardial infarction and cardiovascular collapse due to new onset arrhythmias. Acute MI immediately following IV tPA for stroke is a rare but serious complication. The disruption of intracardiac thrombus and subsequent embolization to coronary arteries may be an important mechanism in the occurrence of MI after administration of tPA for acute ischemic stroke. As both the patients succumbed before the arrangement for coronary angiography, the demonstration of intracardiac or intracoronary thrombus was not possible. But clinically, the presence of chest pain with elevated troponin levels and ST segment elevation pointed to MI. We suspect that fragmentation and lysis of intracardiac thrombus may result in MI after use of tPA for acute ischemic stroke, though the remote possibility of simultaneous occurrence of two atherosclerotic events MI and stroke exists.
A case study of the use of verbal reports for talent identification purposes in soccer: A Messi affair!
Authors: Matthew J Reeves, Allistair P McRobert, Colin J Lewis, Simon J Roberts
Journal: PLoS One (2019)
MeSH terms: Aptitude, Research Report, Soccer, Adult, Cognition, Humans, Male, Young Adult

Using a two-study approach, the main purpose of this case study was to explore the use of a verbal reporting methodology to better understand the thought processes of soccer talent scouts during an in-situ talent identification environment. Study 1 developed a standardized coding-scheme to examine verbal cognitions during a single soccer game. Study 2 then utilized this methodology to examine two full-time recruitment staff trained in the use of concurrent verbal reporting before undertaking a live, in-game task. Participants also participated in a debrief interview following the game. The findings of the two studies suggest that developing a verbal reporting protocol is viable, however when applied in a live-game environment it is problematic. Future research should therefore consider a modified version of this task to further explore the cognitions of scouts whilst observing and identifying potential talent.
Overlapping of Serotonin Syndrome with Neuroleptic Malignant Syndrome due to Linezolid-Fluoxetine and Olanzapine-Metoclopramide Interactions: A Case Report of Two Serious Adverse Drug Effects Caused by Medication Reconciliation Failure on Hospital Admission
Authors: Faizan Mazhar, Shahzad Akram, Nafis Haider, Rafeeque Ahmed
Journal: Case Rep Med (2016)

Antipsychotic and antidepressant are often used in combination for the treatment of neuropsychiatric disorders. The concomitant use of antipsychotic and/or antidepressant with drugs that may interact can lead to rare, life-threatening conditions such as serotonin syndrome and neuroleptic malignant syndrome. We describe a patient who has a history of taking two offending drugs that interact with drugs given during the course of hospital treatment which leads to the development of serotonin syndrome overlapped with neuroleptic malignant syndrome. The physician should be aware that both NMS and SS can appear as overlapping syndrome especially when patients use a combination of both antidepressants and antipsychotics.
Anaphylaxis to three humanized antibodies for severe asthma: a case study
Authors: Koichi Jingo, Norihiro Harada, Toshihiko Nishioki, Masahiro Torasawa, Tomoko Yamada, Tetsuhiko Asao, Haruhi Takagi, Tomohito Takeshige, Jun Ito, Kazuhisa Takahashi
Journal: Allergy Asthma Clin Immunol (2020)
Keywords: anaphylaxis, benralizumab, humanized antibody, mepolizumab, omalizumab
MeSH terms: Case Reports

Background:
Omalizumab, mepolizumab, benralizumab, and dupilumab are the currently available biologics used to treat asthma in Japan. Anaphylaxis following treatment with mepolizumab or benralizumab is considered rare.
Case presentation:
We report the case of a 35-year-old woman with severe asthma, who experienced anaphylaxis following the administration of benralizumab, mepolizumab, and omalizumab, separately. The therapy with biologics was chosen to avoid the repeated use of systemic corticosteroids for asthma exacerbations. The mechanisms underlying anaphylaxis caused by these three biologics remain unclear. The patient's asthma symptoms and lung function improved after treatment with bronchial thermoplasty.
Conclusions:
To our knowledge, this is the first report of an asthmatic patient developing anaphylaxis after commencement of benralizumab, mepolizumab, and omalizumab therapy. These three biologics should be administered carefully, and patients should be monitored for anaphylaxis.
Case of Primary Breast and Ipsilateral Axillary T-Cell Lymphoma: a Rare Occurrence
Authors: Faryal Afridi, Garry D Ruben, Eric Oristian
Journal: Case Rep Surg (2020)
MeSH terms: Case Reports

Background:
Malignant lymphomas of the breast are rare and can be primary or secondary. Non-Hodgkin Lymphoma involving the breast is even rarer comprising 0.04-0.5% of all breast malignancies (Takemura). The incidence is even lower for T-cell lymphomas compared with B-cell subtype. We report the rare incidence of primary T-cell lymphoma involving both breast and ipsilateral axilla.
Case:
This is the case of an 80-year-old female who initially presented with asymmetry of her right breast. Initial mammograms were inconclusive. MRI could not be performed due to the patient's severe claustrophobia. The patient was then lost to follow-up but re-presented with a new palpable density in the same breast. Subsequent mammogram showed a suspicious lesion with suspicious right axillary lymphadenopathy. Core biopsy was consistent with T-cell lymphoproliferative disorder involving both the breast and the axilla. She was then referred to medical oncology for management.
Conclusion:
Although rare, lymphoproliferative disorders of the breast can be encountered during workup for suspicious breast lesions. It is imperative that the surgeon is aware of this rare diagnosis to facilitate appropriate therapeutic intervention.
Inflammatory Myofibroblastic Bladder Tumor in a Patient with Von Recklinghausen's Syndrome
Authors: Eleftherios Chatzidarellis, Evangelos Mazaris, Andreas Skolarikos, Demonakou Maria, Iraklis Mitsogiannis, Nafsika Mousiou, Apostolos Bisas
Journal: Case Rep Med (2010)
MeSH terms: Case Reports

Myofibroblastic tumor, also known as inflammatory pseudotumor or pseudosarcoma, is a benign tumor with mesenchymal origin. Bladder location is very uncommon. We report the case of a 58-year-old man with a history of von Recklinghausen's disease who complained for painless macroscopic hematuria 5 months after suprapubic prostatectomy. The radiograph evaluation revealed a bladder tumor, and the pathologic examination following a transurethral resection showed inflammatory myofibroblastic tumor of the bladder. The patient finally underwent a radical cystectomy due to the uncertain pathogenesis of inflammatory myofibroblastic tumor as well as the rarity of cases published on bladder tumors in Von Recklinghausen's patients.
Hip Pain in a Child Caused by Coxal Bone Infection
Authors: Matthieu Wendling, Maxime Gudelj
Journal: J Belg Soc Radiol (2021)
Keywords: ischiopubic synchondrosis, magnetic resonance imaging, osteomyelitis
MeSH terms: Case Reports

Teaching Point: Ischiopubic synchondrosis osteomyelitis is not rare but frequently misdiagnosed. MRI has a key role for early diagnosis and detection of complications.
Aggressive Natural Killer Cell Leukemia in an Adolescent Patient: A Case Report and Literature Review
Authors: Rong Yang, Yuan Ai, Chuan Liu, Xiaoxi Lu
Journal: Front Pediatr (2022)
Keywords: epstein-barr virus, aggressive natural killer cell leukemia, case report, children, hemophagocytic lymphohistiocytosis
MeSH terms: Case Reports

Aggressive natural killer cell leukemia (ANKL) is a rare malignant tumor, especially uncommon in children. ANKL has very aggressive clinical course and bad prognosis and is usually caused by Epstein-Barr virus infection. ANKL often has clinical manifestations of hemophagocytic lymphohistiocytosis (HLH) and can be easily treated as HLH, which might complicate this aggressive disease. Here we report an ANKL in adolescent whose clinical presentation was highly aggressive and response to L-asparaginase containing chemotherapy was very bad. Early-onset Flow cytometry of peripheral blood and bone marrow help make the diagnosis.
Oral Phenotype and Salivary Microbiome of Individuals With Papillon-Lefèvre Syndrome
Authors: Giulia Melo Lettieri, Luander Medrado Santiago, Giancarlo Crosara Lettieri, Luiz Gustavo Dos Anjos Borges, Letícia Marconatto, Laudimar Alves de Oliveira, Nailê Damé-Teixeira, Loise Pedrosa Salles
Journal: Front Cell Infect Microbiol (2021)
Keywords: papillon–lefèvre disease, cathepsin c, microbiology, periodontal infection, periodontitis, saliva
MeSH terms: Aggressive Periodontitis / genetics, Aggressive Periodontitis / microbiology, Microbiota, Papillon-Lefevre Disease / genetics, Papillon-Lefevre Disease / microbiology, Case Reports, Research Support, Non-U.S. Gov't, Female, Humans, Intercellular Signaling Peptides and Proteins, Phenotype, RNA, Ribosomal, 16S / genetics, Saliva / microbiology, Intercellular Signaling Peptides and Proteins, RNA, Ribosomal, 16S

Papillon-Lefèvre syndrome (PLS) is an autosomal recessive rare disease, main characteristics of which include palmoplantar hyperkeratosis and premature edentulism due to advanced periodontitis (formerly aggressive periodontitis). This study aimed to characterize the oral phenotype, including salivary parameters, and the salivary microbiome of three PLS sisters, comparatively. Two sisters were toothless (PLSTL1 and PLSTL2), and one sister had most of the teeth in the oral cavity (PLST). Total DNA was extracted from the unstimulated saliva, and the amplicon sequencing of the 16S rRNA gene fragment was performed in an Ion PGM platform. The amplicon sequence variants (ASVs) were obtained using the DADA2 pipeline, and the taxonomy was assigned using the SILVA v.138. The main phenotypic characteristics of PLS were bone loss and premature loss of primary and permanent dentition. The PLST sister presented advanced periodontitis with gingival bleeding and suppuration, corresponding to the advanced periodontitis as a manifestation of systemic disease, stage IV, grade C. All three PLS sisters presented hyposalivation as a possible secondary outcome of the syndrome. Interestingly, PLST salivary microbiota was dominated by the uncultured bacteria Bacterioidales (F0058), Fusobacterium, Treponema, and Sulfophobococcus (Archaea domain). Streptococcus, Haemophilus, and Caldivirga (Archaea) dominated the microbiome of the PLSTL1 sister, while the PLSTL2 had higher abundances of Lactobacillus and Porphyromonas. This study was the first to show a high abundance of organisms belonging to the Archaea domain comprising a core microbiome in human saliva. In conclusion, a PLST individual does have a microbiota different from that of the periodontitis' aggressiveness previously recognized. Due to an ineffective cathepsin C, the impairment of neutrophils probably provided a favorable environment for the PLS microbiome. The interactions of Bacteroidales F0058, Caldivirga, and Sulfophobococcus with the microbial consortium of PLS deserves future investigation. Traditional periodontal therapy is not efficient in PLS patients. Unraveling the PLS microbiome is essential in searching for appropriate treatment and avoiding early tooth loss.
Remarkable regression of massive deep vein thrombosis in response to intensive oral rivaroxaban treatment
Authors: Norimichi Koitabashi, Nogiku Niwamae, Tetsuya Taguchi, Yoshiaki Ohyama, Noriaki Takama, Masahiko Kurabayashi
Journal: Thromb J (2015)
Keywords: anticoagulation, deep vein thrombosis, iliac vein compression, rivaroxaban, thrombus regression
MeSH terms: Case Reports

Deep vein thrombosis (DVT) is a common disease and is associated with pulmonary embolism (PE). Proximal iliofemoral DVT may lead to severe PE and chronic venous insufficiency. The standard therapy for DVT is anticoagulant therapy using heparin and a vitamin K antagonist, but a recent clinical study showed that rivaroxaban, an oral Xa inhibitor, was comparable to standard therapy and had less bleeding complications. Intensive high-dose anticoagulation is recommended during the initial 3 weeks of DVT treatment. The present report describes a case of a 77-year-old male showing a remarkable regression of DVT in response to rivaroxaban treatment within the initial 3 weeks of therapy and who did not experience any adverse events. His DVT was massive and was accompanied by proximal iliofemoral vein thrombus and iliac vein compression syndrome. Rivaroxaban, especially in intensive high-dose treatment, might be a safe and effective therapeutic choice for massive DVT.
Phenotypic variability in a French family with a novel mutation in the BEST1 gene causing multifocal best vitelliform macular dystrophy
Authors: Emmanuelle Lacassagne, Aurore Dhuez, Florence Rigaudière, Anouk Dansault, Christelle Vêtu, Karine Bigot, Véronique Vieira, Bernard Puech, Sabine Defoort-Dhellemmes, Marc Abitbol
Journal: Mol Vis (2011)
MeSH terms: Chloride Channels / genetics, Eye Proteins / genetics, Mutation, Vitelliform Macular Dystrophy / genetics, Case Reports, Research Support, Non-U.S. Gov't, Adolescent, Adult, Alleles, Bestrophins, Child, Electrooculography / methods, Electroretinography / methods, Exons, Family Health, Female, France, Humans, Male, Middle Aged, Pedigree, Phenotype, Retina / pathology, Sequence Analysis, DNA, Tomography, Optical Coherence / methods, BEST1 protein, human, Bestrophins, Chloride Channels, Eye Proteins

Aims:
To describe genetic and clinical findings in a French family affected by best vitelliform macular dystrophy (BVMD).
Methods:
We screened eight at-risk members of a family, including a BVMD-affected proband, by direct sequencing of 11 bestrophin-1 (BEST1) exons. Individuals underwent ophthalmic examination and autofluorescent fundus imaging, indocyanine green angiography, electro-oculogram (EOG), electroretinogram (ERG), multifocal ERG, optical coherence tomography (OCT), and where possible, spectral domain OCT.
Results:
The sequence analysis of the BEST1 gene revealed one previously unknown mutation, c.15C>A (p.Y5X), in two family members and one recently described mutation, c.430A>G (p.S144G), in five family members. Fundus examination and electrophysiological responses provided no evidence of the disease in the patient carrying only the p.Y5X mutation. Three patients with the p.S144G mutation did not show any preclinical sign of BVMD except altered EOGs. Two individuals of the family exhibited a particularly severe phenotype of multifocal BVMD-one individual carrying the p.S144G mutation heterozygously and one individual harboring both BEST1 mutations (p.S144G inherited from his mother and p.Y5X from his father). Both of these family members had multifocal vitelliform autofluorescent lesions combined with abnormal EOG, and the spectral domain OCT displayed a serous retinal detachment. In addition, ERGs demonstrated widespread retinal degeneration and multifocal ERGs showed a reduction in the central retina function, which could be correlated with the decreased visual acuity and visual field scotomas.
Conclusions:
A thorough clinical evaluation found no pathological phenotype in the patient carrying the isolated p.Y5X mutation. The patients carrying the p.S144G variation in the protein exhibited considerable intrafamilial phenotypic variability. Two young affected patients in this family exhibited an early onset, severe, multifocal BVMD with a diffuse distribution of autofluorescent deposits throughout the retina and rapid evolution toward the loss of central vision. The other genetically affected relatives had only abnormal EOGs and displayed no or extremely slow electrophysiological evolution.
Case Report: A Novel Genetic Mutation Causes Idiopathic Infantile Arterial Calcification in Preterm Infants
Authors: Liu Yunfeng, Han Tongyan, Wang Jing, Tong Xiaomei
Journal: Front Genet (2021)
Keywords: artery, calcification, case, genetic mutation, hypertensive, infant, preterm, report
MeSH terms: Case Reports

Idiopathic infantile arterial calcification (IIAC), also known as generalized arterial calcification of infancy (GACI), is a heritable ectopic mineralization disorder that results in diffuse arterial calcifications and or stenosis, which are attributed to mutations in the ENPP1 gene. In this case study, we report the development of IIAC in a 2-month-old male preterm infant. The patient presented with severe hypertension and seizures, which revealed diffused calcifications and c.130C > T and c.1112A > T mutations in the ENPP1 gene. With biphosphonate, antihypertensive, and control epilepsy therapy, his blood pressure was maintained at 110-120/50-60 mmHg. Intellectual motor development retardation was anticipated in this patient. To the best of our knowledge, this is the first case in which a novel c.130C > T mutation in the ENPP1 gene has been identified, and the administration of bisphosphonates to patients with IIAC has been assessed.
In-office arthroscopy for the evaluation of chronic knee pain: A case report
Authors: Jacob A West, Nirav H Amin
Journal: SAGE Open Med Case Rep (2017)
Keywords: sports medicine, arthroscopy, meniscal tear
MeSH terms: Case Reports

This is a case report detailing the use of in-office needle arthroscopy (mi-eye 2™) in a patient with chronic knee pain and inconclusive magnetic resonance imaging findings. The patient is a 40-year-old male who presented to our clinic after an extended history of right knee pain along the medial aspect with previous failed treatments. Magnetic resonance imaging without contrast had demonstrated full-thickness chondral fissuring of the lateral patellar facet, mild abnormal signals of the proximal patellar tendon and Hoffa's fat pad, and intact anterior cruciate ligament and posterior cruciate ligament. The patient was previously treated with an ultrasound-guided injection of 2 cm3 of 1% lidocaine without epinephrine and 1 cm3 of Kenalog-40 and scheduled for follow-up. At follow-up, clinical examination showed antalgic gait, minimal tenderness along medial joint line, medial pain in deep flexion, and no pain when in varus or valgus. Due to continued discomfort with a negative magnetic resonance imaging, in-office diagnostic arthroscopy was performed using mi-eye 2 revealing a tear of the mid-body of the medial meniscus. The patient subsequently underwent arthroscopic repair and is recovering well with complete resolution of medial joint pain. This report highlights the clinical utility of in-office diagnostic arthroscopy in the management of patients with persistent knee pain and negative or equivocal findings on magnetic resonance imaging.
Case report: Pneumonia with clinical symptoms precedes imaging evidence after immune checkpoint inhibitors combined with radiotherapy in lung squamous cell cancer
Authors: Yao Wang, Yimeng Wang, Jinming Yu, Xiangjiao Meng
Journal: Front Immunol (2022)
Keywords: cancer immunotherapy, immune checkpoint inhibitors (ici), immune-related adverse event(irae), pneumonitis, programmed cell death 1 inhibitor
MeSH terms: Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Lung Neoplasms, Pneumonia / chemically induced, Pneumonia / drug therapy, Case Reports, Research Support, Non-U.S. Gov't, B7-H1 Antigen, Epithelial Cells, Humans, Immune Checkpoint Inhibitors / adverse effects, Ligands, Lung, Programmed Cell Death 1 Receptor, B7-H1 Antigen, Immune Checkpoint Inhibitors, Ligands, Programmed Cell Death 1 Receptor

Immune-checkpoint inhibitors (ICI) targeting programmed cell death 1 (PD-1) and its ligand 1 (PD-L1) have quickly changed the treatment landscape in advanced non-small cell lung cancer. However, any patient treated with an immune checkpoint inhibitor is at risk for immune-related adverse events (irAEs). Checkpoint inhibitor pneumonitis (CIP) is a rare but potentially severe pulmonary toxicity of immunotherapy. Since the imaging features and symptoms are not specific, the diagnosis of CIP is challenging. In addition, CIP may mimic other lung diseases. Due to these characteristics, proper patient management may be delayed. So, a comprehensive understanding of imaging features is essential for a prompt detection and correct management of these drug-induced lung diseases. We presented a patient with lung squamous cell cancer who has clinical symptoms preceding imaging evidence of pneumonitis after immunotherapy and radiotherapy. We also discussed the safety of immunotherapy, the complexity and management of immune pneumonitis.
Acute Renal Failure and Jaundice without Methemoglobinemia in a Patient with Phenazopyridine Overdose: Case Report and Review of the Literature
Authors: Ian Holmes, Nathaniel Berman, Vinicius Domingues
Journal: Case Rep Nephrol (2014)

Phenazopyridine is a commonly used urinary analgesic available throughout the United States. Ingestion of large quantities can lead to methemoglobinemia, hemolytic anemia, jaundice, and acute renal failure. We report a case of a 78-year-old male with previously normal renal function who developed acute renal failure and jaundice without methemoglobinemia or hyperbilirubinemia after taking nearly 8 g of phenazopyridine over the course of 4 days. Initially presenting with oliguria, the urine output began to increase by day 2 of his admission, and the creatinine peaked 11 days after he began taking phenazopyridine, and he was discharged safely soon after. To our knowledge, this is the first such case of renal failure and jaundice without methemoglobinemia or hemolytic anemia in an adult patient with normal renal function.
Isolated septic non-otogenic lateral sinus thrombosis complicating nasopharyngitis in a 2-month-old infant: a case report
Authors: Peter Waweru, Alice Wakonyo, Hussein Dossajee, Bhupi Reel
Journal: BJR Case Rep (2017)
MeSH terms: Case Reports

Nasopharyngeal infections are among the commonest diagnosed infections in infants. Largely treated supportively, these infections are considered harmless. These can however lead to serious complications from local spread and septicemia. With local extension, inflammatory neck masses (abscesses) can swiftly lead to life-threatening complications including mediastinitis, airway compromise and sinovenous thrombosis. Here, we report a 2-month-old infant with initial rhinopharyngitis and subsequent extensive deep neck abscesses with consequent dural sinus thrombosis successfully managed with antibiotics, anticoagulants and drainage. While such cases have been presented before, it is the pathophysiology and extent of sinus thrombosis in our case that is eccentric.