OpenMed/multicare-articles huggingface dataset:
Osteochondral autograft transplantation for malunited intra-articular fracture of the proximal interphalangeal joint: a case report
Authors: Nobuo Yamagami, Soichiro Yamamoto, Yumiko Tsujimoto, Yuji Uchio
Journal: Arch Orthop Trauma Surg (2013)
MeSH terms: Finger Injuries / surgery, Finger Joint / surgery, Fractures, Malunited / surgery, Intra-Articular Fractures / surgery, Case Reports, Adolescent, Athletic Injuries / surgery, Baseball / injuries, Cartilage, Articular / injuries, Humans, Male, Transplantation, Autologous

Introduction:
Malunited intra-articular fracture of the proximal inter-phalangeal (PIP) joint sometimes causes problems, such as range of motion (ROM) limitation in the joint or lack of digital dexterity; however, the treatment method has not yet been established. We report a juvenile case of osteochondral autograft tranplantation to treat a malunited intra-articular fracture of the middle finger.
Case report:
A 14-year-old boy was injured at the right middle finger by a baseball impact and underwent conservative treatment. At 5 months after the injury, he complained of continuing pain and restricted ROM. Plain X-ray and CT images showed a bony defect in the articular surface of the PIP joint of the right middle finger. He was diagnosed with malunited intra-articular fracture of the PIP joint and underwent surgical treatment. First, through a palmar incision, a columnar-shaped drill hole was made at the recipient site of osteochondral defect. Then a cylindrical osteochondral plug, 4.5 mm in diameter, harvested from the knee, was inserted into the recipient hole and press-fitted. One year after surgery, the patient has neither pain nor ROM limitation of the finger and the knee joint. MRI showed smooth articular surface of the PIP joint.
Discussion:
The benefits of our method include use of articular cartilage as a reconstruction material, availability for a relatively large cartilage defect, and stability of the autograft for the press-fitting method, which enable early mobilization exercise after surgery.
Aberrant CDK4 amplification in refractory rhabdomyosarcoma as identified by genomic profiling
Authors: Silvia Park, Jeeyun Lee, In-Gu Do, Jiryeon Jang, Kyoohyoung Rho, Seonjoo Ahn, Lira Maruja, Sung Joo Kim, Kyoung-Mee Kim, Mao Mao, Ensel Oh, Yu Jin Kim, Jhingook Kim, Yoon-La Choi
Journal: Sci Rep (2014)
MeSH terms: Cyclin-Dependent Kinase 4 / genetics, Gene Expression Profiling, Genome, Human, Rhabdomyosarcoma / genetics, Case Reports, Research Support, Non-U.S. Gov't, Adult, Chromosomes, Human, Pair 12, Comparative Genomic Hybridization, Disease Progression, Humans, Male, Neoplasm Metastasis, Proto-Oncogene Mas, Rhabdomyosarcoma / diagnostic imaging, Rhabdomyosarcoma / pathology, Tomography, X-Ray Computed, MAS1 protein, human, Proto-Oncogene Mas, CDK4 protein, human, Cyclin-Dependent Kinase 4

Rhabdomyosarcoma (RMS) is the most commonly occurring type of soft tissue tumor in children. However, it is rare in adults, and therefore, very little is known about the most appropriate treatment strategy for adult RMS patients. We performed genomic analysis of RMS cells derived from a 27-year-old male patient whose disease was refractory to treatment. A peritoneal seeding nodule from the primary tumor, pleural metastases, malignant pleural effusion, and ascites obtained during disease progression, were analyzed. Whole exome sequencing revealed 23 candidate variants, and 10 of 23 mutations were validated by Sanger sequencing. Three of 10 mutations were present in both primary and metastatic tumors, and 3 mutations were detected only in metastatic specimens. Comparative genomic hybridization array analysis revealed prominent amplification in the 12q13-14 region, and more specifically, the CDK4 proto-oncogene was highly amplified. ALK overexpression was observed at both protein and RNA levels. However, an ALK fusion assay using NanoString technology failed to show any ALK rearrangements. Little genetic heterogeneity was observed between primary and metastatic RMS cells. We propose that CDK4, located at 12q14, is a potential target for drug development for RMS treatment.
Oral Rehabilitation and Management for Secondary Sjögren's Syndrome in a Child
Authors: Tatiana Kelly da Silva Fidalgo, Carla Nogueira, Marcia Rejane Thomas Canabarro Andrade, Andrea Graciene Lopez Ramos Valente, Patricia Nivoloni Tannure
Journal: Case Rep Dent (2016)

The aim of this paper is to describe a rare case report of a pediatric patient with secondary Sjögren's syndrome (SSS). A 12-year-old female child was referred to the Pediatric Dentistry Clinic with the chief complaint of tooth pain, dry mouth, and tooth sensibility. The patient was submitted to orthodontic treatment prior to syndrome diagnosis. The clinical treatment consisted of the interruption of orthodontic treatment and restoring the oral condition with dental treatment and the use of artificial saliva in an innovative apparatus. Dental therapy involved the control of dental caries, periodontal disease, and opportunistic fungal infections and the use of fluoride-rich solutions. The present clinical case describes clinical and laboratory aspects of SSS in pediatric patients. The management of the oral findings promoted an improvement in the oral health status and quality of life of the child.
Mass antibiotic treatment for group A streptococcus outbreaks in two long-term care facilities
Authors: Andrea Smith, Aimin Li, Ornella Tolomeo, Gregory J Tyrrell, Frances Jamieson, David Fisman
Journal: Emerg Infect Dis (2003)
MeSH terms: Anti-Bacterial Agents / therapeutic use, Disease Outbreaks, Streptococcal Infections / drug therapy, Streptococcal Infections / epidemiology, Streptococcus pyogenes / classification, Streptococcus pyogenes / genetics, Streptococcus pyogenes / isolation & purification, Research Support, Non-U.S. Gov't, Aged, Aged, 80 and over, Female, Homes for the Aged, Humans, Long-Term Care, Male, Molecular Epidemiology, Nursing Homes, Ontario / epidemiology, Streptococcal Infections / transmission, Anti-Bacterial Agents

Outbreaks of invasive infections caused by group A β-hemolytic streptococcus (GAS) may occur in long-term care settings and are associated with a high case-fatality rate in debilitated adults. Targeted antibiotic treatment only to residents and staff known to be at specific risk of GAS may be an ineffective outbreak control measure. We describe two institutional outbreaks in which mass antibiotic treatment was used as a control measure. In the first instance, mass treatment was used after targeted antibiotic treatment was not successful. In the second instance, mass treatment was used to control a rapidly evolving outbreak with a high case-fatality rate. Although no further clinical cases were seen after the introduction of mass antibiotic treatment, persistence of the outbreak strain was documented in one institution >1 year after cases had ceased. Strain persistence was associated with the presence of a chronically colonized resident and poor infection control practices.
Gastric-type mucinous endocervical adenocarcinomas: A case report and literature review
Authors: Junling Lu, Jing Na, Ya Li, Xinyou Wang, Jun Wang, Shichao Han
Journal: Front Cell Infect Microbiol (2022)
Keywords: adenocarcinoma, diagnosis, gastric type, human papillomavirus, mucinous, therapy
MeSH terms: Adenocarcinoma / diagnosis, Adenocarcinoma / pathology, Adenocarcinoma, Mucinous / diagnostic imaging, Papillomavirus Infections, Stomach Neoplasms, Uterine Cervical Neoplasms / diagnosis, Review, Case Reports, Female, Humans, Positron Emission Tomography Computed Tomography

Gastric-type mucinous endocervical adenocarcinomas (GAS) are new variant types of cervical adenocarcinomas according to the 2014 World Health Organization (WHO) classification. GAS is a unique disease that can be differentiated from typical adenocarcinomas-it is less common and more aggressive and likely to have deep invasion and horizontal diffusion, invasion of the uterus and vagina, early distant metastases, and a lower 5-year survival rate compared to the usual-type cervical cancer. At present, initial treatment and postoperative adjuvant therapy are not conclusive, but early detection and early treatment are a consensus that can improve prognosis. Most of its occurrence has nothing to do with human papillomavirus (HPV) infection. Whether it is only negative for the subtypes that can be detected at present and whether it may be an unknown subtype of infection need to be further explored in the future. The clinical symptoms commonly include aqueous secretion, lower abdominal pain, and elevated serum carbohydrate antigen-19-9 (CA19-9) levels, which may be helpful for diagnosis. MRI and PET-CT can help to describe the characteristics of lesions and judge the state of the systemic metastasis. We believe that early detection and surgical treatment will give patients more benefits. Looking for potential gene and molecular changes and establishing biomarkers to identify molecular targets will be the key to early identification and target therapy.
Development of bile duct bezoars following cholecystectomy caused by choledochoduodenal fistula formation: a case report
Authors: Jamal Akhavan Moghaddam, Mohsen Amini, Soheil Adibnejad
Journal: BMC Gastroenterol (2006)
MeSH terms: Bezoars / etiology, Bile Ducts, Biliary Fistula / complications, Cholecystectomy, Common Bile Duct Diseases / complications, Duodenal Diseases / complications, Intestinal Fistula / complications, Case Reports, Biliary Fistula / diagnostic imaging, Cholangiopancreatography, Endoscopic Retrograde, Cholelithiasis / surgery, Common Bile Duct Diseases / diagnostic imaging, Duodenal Diseases / diagnostic imaging, Female, Humans, Intestinal Fistula / diagnostic imaging, Jaundice, Obstructive / etiology, Middle Aged, Postoperative Complications

Background:
The formation of bile duct bezoars is a rare event. Its occurrence when there is no history of choledochoenteric anastomosis or duodenal diverticulum constitutes an extremely scarce finding.
Case presentation:
We present a case of obstructive jaundice, caused by the concretion of enteric material (bezoars) in the common bile duct following choledochoduodenal fistula development. Six years after cholecystectomy, a 60-year-old female presented with abdominal pain and jaundice. Endoscopic retrograde cholangiopancreatography demonstrated multiple filling defects in her biliary tract. The size of the obstructing objects necessitated surgical retrieval of the stones. A histological assessment of the objects revealed fibrinoid materials with some cellular debris. Post-operative T-tube cholangiography (9 days after the operation) illustrated an open bile duct without any filling defects. Surprisingly, a relatively long choledochoduodenal fistula was detected. The fistula formation was assumed to have led to the development of the bile duct bezoar.
Conclusion:
Bezoar formation within the bile duct should be taken into consideration as a differential diagnosis, which can alter treatment modalities from surgery to less invasive methods such as more intra-ERCP efforts. Suspicions of the presence of bezoars are strengthened by the detection of a biliary enteric fistula through endoscopic retrograde cholangiopancreatography. Furthermore, patients at a higher risk of fistula formation should undergo a thorough ERCP in case there is a biliodigestive fistula having developed spontaneously.
Myocardial hydatid cyst in a young male patient who feeds pet at home: a case report
Authors: Sinan Demirtas, Celal Yavuz, Ismail Basyigit, Ugur Firat, Ahmet Caliskan
Journal: Case Rep Vasc Med (2012)

Hydatid cysts are rarely asymptomatic depending on their location. Complaints may be only relevant due to secondary problems. This paper presents a case report of a myocardial hydatid cyst which was totally excised under cardiopulmonary bypass operation with median sternotomy. Patient was admitted to the hospital with complaint of atypical chest pain in pungent manner together with shortness of breath. Various methods are used for diagnosis. However, echocardiography and computerized tomography with contrast are usually enough for definitive diagnosis and for deciding the strategy of operation. Curative excision must be performed. Extra care should be provided during the operation in order to prevent contamination. Postoperative appropriate antibiotherapy must be administered. Environment should be changed, and infrastructure must be improved in order to prevent further recurrences.
Angioleiomyoma: a rare cause of fixed flexion contracture of the elbow
Authors: Asterios Dramis, Robert J Grimer
Journal: Sarcoma (2006)
MeSH terms: Case Reports

We describe an unusual case of a patient presented with a painless fixed flexion contracture of the elbow due to an angioleiomyoma. This benign smooth muscle tumour should be considered in the differential diagnosis of flexion contractures of the elbow.
Case Report: Infra-Low-Frequency Neurofeedback for PTSD: A Therapist's Perspective
Authors: Regula Spreyermann
Journal: Front Hum Neurosci (2022)
Keywords: c-ptsd, hyperarousal, neurofeedback combined with psychotherapy, neurofeedback for ptsd, post-traumatic stress disorder (ptsd), trauma
MeSH terms: Case Reports

The practical use of a combination of trauma psychotherapy and neurofeedback [infra-low-frequency (ILF) neurofeedback and alpha-theta training] is described for the treatment of patients diagnosed with complex post-traumatic stress disorder (C-PTSD). The indication for this combined treatment is the persistence of symptoms of a hyper-aroused state, anxiety, and sleep disorders even with adequate trauma-focused psychotherapy and supportive medication, according to the Guidelines of the German Society of Psycho-Traumatology (DeGPT). Another indication for a supplementary treatment with neurofeedback is the persistence of dissociative symptoms. Last but not least, the neurofeedback treatment after a trauma-focused psychotherapy session helps to calm the trauma-related reactions and to process the memories. The process of the combined therapy is described and illustrated using two representative case reports. Overall, a rather satisfying result of this outpatient treatment program can be seen in the qualitative appraisal of 7 years of practical application.
Acute Pericarditis Occurring Three Days after Intravesical Instillation of Mitomycin C after Transurethral Bladder Tumor Resection in a 64-Year-Old Woman
Authors: Vineet Meghrajani, Arsalan Hashmi, Shuo Cheng Lin, Zvi Plawes, Shelly Brejt
Journal: Case Rep Cardiol (2018)
MeSH terms: Case Reports

We present a 64-year-old woman who developed symptoms of acute pericarditis three days after undergoing intravesical instillation of mitomycin C following transurethral bladder tumor resection. Mitomycin C is a chemotherapeutic agent which acts by alkylation of DNA and is known to be cardiotoxic when systemically administered. Despite classic pericarditis symptoms, the patient underwent an urgent coronary angiogram due to elevated cardiac troponin I level, EKG changes, and wall motion abnormalities on her echocardiogram. During her angiogram, it was found that she had multiple stenotic coronary artery lesions, with no acute total coronary occlusions, and percutaneous coronary intervention (PCI) was done with placement of a single drug-eluting stent for a 95% stenotic lesion in the left anterior descending artery. The patient was discharged after an uneventful hospitalization on dual antiplatelet therapy with aspirin and prasugrel, and colchicine for pericarditis. It is likely that the patient's presentation was the result of a perimyocardial inflammatory process secondary to intravesically administered mitomycin C, rather than an acute coronary syndrome. While the pathophysiological basis of cardiotoxicity of systemically administered mitomycin C is well documented, more studies are needed to determine whether intravesical MMC may cause cardiotoxicity.
The epidemiology of invasive disease due to Haemophilus influenzae serotype a in the Canadian North from 2000 to 2010
Authors: Jenny L Rotondo, Lindsey Sherrard, Melissa Helferty, Raymond Tsang, Shalini Desai
Journal: Int J Circumpolar Health (2013)
Keywords: aboriginal, arctic, haemophilus influenzae, hia, northern canada, emerging infections, infectious diseases, invasive bacterial diseases, surveillance
MeSH terms: Bacteremia / epidemiology, Communicable Diseases, Emerging / epidemiology, Disease Outbreaks, Haemophilus Infections / epidemiology, Haemophilus influenzae / isolation & purification, Adolescent, Adult, Arctic Regions / epidemiology, Bacteremia / microbiology, Bacteremia / physiopathology, Canada / epidemiology, Child, Child, Preschool, Communicable Diseases, Emerging / microbiology, Female, Haemophilus Infections / diagnosis, Haemophilus influenzae / classification, Health Surveys, Humans, Incidence, Infant, Male, Retrospective Studies, Risk Assessment, Serotyping

Introduction:
The International Circumpolar Surveillance (ICS) project is a population-based surveillance network. Since 2000, Canada has participated in the ICS Invasive Bacterial Disease Working Group's surveillance of invasive disease due to Haemophilus influenzae (Hi).
Methods:
A standardized case report form containing demographic and clinical information was completed for all reported Hi cases in the study regions. Isolates were sent to a reference laboratory for confirmation and serotyping. Analysis was conducted on all Hi serotype a (Hia) cases reported from 2000 to 2010. The northern Canadian population was estimated using Statistics Canada information.
Results:
Of the 130 Hi cases reported from 2000 to 2010, 72 (56% of cases with serotype information) were due to Hia. The number of Hia cases reported each year ranged from 2 in 2008 to 13 in 2010. The average Hia incidence over the 11 years was 4.6 cases per 100,000 population per year. The majority of Hia occurred in infants less than 2 years of age (73% of cases). This age group had an average annual incidence of 87.5 cases per 100,000 population. Among cases for which ethnicity was indicated, 91% of Hia cases reported Aboriginal status with the average incidence being 6.9 cases per 100,000 population per year. The most common clinical presentation was meningitis (reported in 37% of cases), followed by bacteraemia (34%) and pneumonia (27%). More than 90% of cases were hospitalized, and there were 4 deaths, resulting in a case fatality ratio of 5.6%.
Conclusion:
In the last decade, Hia has become an important cause of morbidity and mortality in the Canadian North. More detailed surveillance information from a national perspective is needed. Further work on vaccine development should be encouraged.
Learning from success cases: ecological analysis of potential pathways to universal access to family planning care in low- and middle-income countries
Authors: Franciele Hellwig, Aluisio Jd Barros
Journal: Gates Open Res (2023)
Keywords: contraception, family planning, health equity, reproductive health, universal access

Background Universal access to family planning services is a well-recognized human right and several countries and organizations are committed to this goal. Our objective was to identify countries who improved family planning coverage in the last 40 years and investigate which contexts enabled those advances. Methods Analyses were based on data from publicly available national health surveys carried out since 1986 in Egypt, Ethiopia, Rwanda, Afghanistan, Brazil, and Ecuador, selected based on previous evidence. We estimated demand for family planning satisfied with modern methods (mDFPS) for each country and explored inequalities in terms of wealth, women's education, and women's age. We also explored contextual differences in terms of women's empowerment, percentage of population living in extreme poverty, and share of each type of contraceptive. To better understand political and sociocultural contexts, country case studies were included, based on literature review. Results Patterns of mDFPS increase were distinct in the selected countries. Current level of mDFPS coverage ranged between 94% in Brazil and 38% in Afghanistan. All countries experienced an important reduction in both gender inequality and extreme poverty. According to the share of each type of contraceptive, most countries presented higher use of short-acting reversible methods. Exceptions were Ecuador, where the most used method is sterilization, and Egypt, which presented higher use of long-acting reversible methods. In the first years analyzed, all countries presented huge gaps in coverage according to wealth, women's education and women's age. All countries managed to increase coverage over recent years, especially among women from the more disadvantaged groups. Conclusions Family planning coverage increased along with reductions in poverty and gender inequality, with substantial increases in coverage among the most disadvantaged in recent years. Policies involving primary health care services, provision of various methods, and high quality training of health providers are crucial to increase coverage.
Case Report: Successful Response to Intravenous Immunoglobulin and Steroid Pulses in a Renal Transplant Recipient With Severe Covid-19 Disease and Associated Acute Allograft Failure
Authors: Pedro Rosa-Guerrero, Antonio Trujillo-Aguilera, Juan Molina, Ana Navas, Cristina López-Martín, Aurora Jurado, Alberto Rodríguez-Benot, Álvaro Torres-De-Rueda
Journal: Front Immunol (2021)
Keywords: covid-19, sars-cov-2, case report, cytokine storm, intravenous immunoglobulin, kidney transplantation, steroids
MeSH terms: Anti-Inflammatory Agents / therapeutic use, COVID-19 Drug Treatment, Graft Rejection / drug therapy, Immunoglobulins, Intravenous / therapeutic use, Immunosuppressive Agents / therapeutic use, Kidney Failure, Chronic / therapy, Kidney Transplantation, SARS-CoV-2 / physiology, Steroids / therapeutic use, Transplant Recipients, Case Reports, Acute Disease, COVID-19 / complications, Disease Progression, Humans, Kidney Failure, Chronic / complications, Male, Middle Aged, Renal Dialysis, Respiration, Artificial, Transplantation, Homologous, Anti-Inflammatory Agents, Immunoglobulins, Intravenous, Immunosuppressive Agents, Steroids

The impact of Covid-19 pneumonia caused by SARS-CoV-2 on transplanted populations under chronic immunosuppression seems to be greater than in normal population. Clinical management of the disease, particularly in those patients worsening after a cytokine storm, with or without allograft impairment and using available therapeutic approaches in the absence of specific drugs to fight against the virus, involves a major challenge for physicians. We herein provide evidence of the usefulness of high-dose intravenous immunoglobulin (IVIG) combined with steroid pulses to successfully treat a case of Covid-19 pneumonia in a single-kidney transplanted patient with mechanical ventilation and hemodialysis requirements in the setting of a cytokine storm. A rapid decrease in the serum level of inflammatory cytokines, particularly IL-6, IL-8, TNF-α, MCP-1 and IL-10, as well as of acute-phase reactants such as ferritin, D-dimer and C-reactive protein was observed after the IVIG infusion and methylprednisolone bolus administration with a parallel clinical improvement and progressive allograft function recovery, allowing the patient's final discharge 40 days after the treatment onset. The immunomodulatory effect of IVIG together with the anti-inflammatory and immunosuppressive potential of steroids could be an alternative strategy to treat severe cases of Covid-19 pneumonia associated with an uncontrolled inflammatory response in transplanted populations.