OpenMed/multicare-articles huggingface dataset:
Breast Metastasis of Lung Cancer After Computed Tomography-Guided Core Needle Biopsy: A Case Report
Authors: Rong Zhao, Jun Xing, Jinnan Gao
Journal: Front Surg (2022)
Keywords: breast, case report, lung neoplasms, neoplasm seeding, surgery
MeSH terms: Case Reports

Background:
Needle tract metastasis is a rare complication following percutaneous procedures for malignancy.
Case summary:
This report describes a 49-year-old female with a lump on her right breast. Mass core needle biopsy showed the specimen was an invasive carcinoma, and mastectomy with sentinel lymph node biopsy was performed. What is special about this case was that the patient reported a history of lung cancer and the position of the breast mass was the puncture site of computed tomography-guided core needle biopsy for lung cancer. Immunostaining of paraffin specimen findings indicated the breast mass as a result of lung carcinoma metastasis. The patient's medical history indicated that the malignant tumor in the breast was a core needle tract pulmonary metastasis. The patient underwent the examination and received therapy based on the lung cancer metastasis principle. At 9 months from breast surgery, the patient is alive, in good condition, and with stability of the disease.
Conclusions:
This patient was misdiagnosed. Careful medical history review and multidisciplinary team discussions are important, especially for patients with a history of cancer or invasive operation.
Lipomas as an Extremely Rare Cause for Brachial Plexus Compression: A Case Series and Systematic Review
Authors: Oliver Gembruch, Yahya Ahmadipour, Mehdi Chihi, Thiemo F Dinger, Laurèl Rauschenbach, Daniela Pierscianek, Ramazan Jabbarli, Ulrich Sure, Karsten H Wrede, Anne-Kathrin Uerschels
Journal: J Brachial Plex Peripher Nerve Inj (2021)
Keywords: brachial plexus, intraoperative, lipoma, monitoring, surgery

Introduction Brachial plexus lipomas are extremely rare benign tumors that may cause slow progression of neurological deficits leading to thoracic outlet syndrome. Up to now, surgery remains challenging. The aim of this study is to present our surgical treatment regime and long-term neurological outcome in three cases of giant brachial plexus lipomas and to show results of systematic review. Patients and Methods Retrospective analysis of our database "peripheral nerve lesion" to identify patients suffering from brachial plexus lipomas between January 1, 2012, and December 31, 2019. Systematic review was performed for literature published until March 31, 2020, analyzing PubMed, Google Scholar, Scopus, and the Cochrane Collaboration Library independently by two authors. Results Over the past years, three patients suffering from giant brachial plexus lipomas attended to our neurosurgical department. All patients underwent preoperative magnetic resonance imaging (MRI), ultrasound examinations, and electrophysiological testing. Tumors were removed microsurgically via anterior/posterior, supraclavicular/infraclavicular, and combined approaches. The patients were accessed postoperatively by MRI and clinical follow-up. Systematic review of the literature revealed 22 cases, which were analyzed in regard to demographics, surgical treatment, and neurological outcome. Conclusion Brachial plexus lipomas are an extremely rare cause for brachial plexus compression. Total microsurgical removal with intraoperative electrophysiological monitoring is the treatment of choice with excellent long-term MRI and clinical outcome.
Infantile-onset Pompe disease with neutropenia: Treatment decisions in the face of a unique phenotype
Authors: Mary Riedy, Jeff F Zhang, Taosheng Huang, Anil Kumar Swayampakula
Journal: JIMD Rep (2022)
Keywords: gaa gene, atrial flutter, enzyme replacement therapy, infantile‐onset pompe disease (iopd), neutropenia, ventricular hypertrophy
MeSH terms: Case Reports

Infantile-onset Pompe disease manifests with early signs of cardiomyopathy during the first few days to weeks of life. We present the case of a newborn born via emergency cesarean section with atrial flutter and moderate biventricular hypertrophy who was diagnosed with Pompe disease on New York State newborn screen. Diagnosis was confirmed with repeat leukocyte acid alpha-glucosidase (GAA) enzyme activity, GAA gene sequencing, urine Hex4, and evaluation of Cross-Reactive Immunological Material (CRIM) status. The patient was also found to be persistently neutropenic which to our knowledge has not been previously reported in the literature in association with Pompe disease. This report highlights the impact that newborn screening had on time to diagnosis and initiation of treatment with enzyme replacement therapy. We also discuss how our patient's concurrent neutropenia impacted decision making related to immune tolerance induction prior to starting enzyme replacement therapy.
Efficacy of Omalizumab in Indolent Systemic Mastocytosis
Authors: Calum Slapnicar, Martina Trinkaus, Lisa Hicks, Peter Vadas
Journal: Case Rep Hematol (2019)
MeSH terms: Case Reports

Background:
Systemic mastocytosis (SM) comprises a heterogeneous group of disorders characterized by the proliferation of clonal mast cells in skin and various internal organs. Omalizumab is an established, labelled therapy for allergic asthma and chronic urticaria, but its experience in the efficacy of SM is limited.
Methods:
A retrospective analysis of 6 patients diagnosed with indolent SM treated with omalizumab at St. Michael's Hospital between 2009 and 2018 is described. Reported frequency of anaphylaxis, baseline and follow-up tryptase levels, and SM-related symptoms were captured to measure the control of the disease.
Results:
Of the 5 patients who had experienced unprovoked anaphylaxis prior to treatment with omalizumab, 3 had no further episodes of anaphylaxis following initiation of omalizumab, while the remaining 2 patients had milder multisystem reactions. Significant improvement in cutaneous symptoms was also observed.
Conclusion:
These data suggest that omalizumab provides benefit to patients with SM who remain highly symptomatic in spite of treatment with conventional therapies.
A Case of Heterotopic Ossification in Papillary Renal Cell Carcinoma Type 2
Authors: Facundo Davaro, Elizabeth Davaro, Amna Qureshi, Lindsay Lombardo
Journal: Case Rep Urol (2020)
MeSH terms: Case Reports

Renal cell carcinoma (RCC) is associated with a variety of different histopathologic subtypes in which each subtype may be further subclassified. These entities carry with them unique prognoses and necessitate treatment with specific immunotherapy agents should advanced disease be uncovered. Meanwhile, aberrant physiologic processes may lead to unique histologic findings within these subtypes, further complicating management and prognostication. Heterotopic ossification within RCC is one of these rare occurrences and was once thought to have favorable prognostic implications. We report a case of a young female with papillary type 2 RCC with heterotopic ossification.
Invasive mucormycosis in a patient with liver cirrhosis: case report and review of the literature
Authors: Hussien Elsiesy, Mohamed Saad, Mahmoud Shorman, Samir Amr, Faisal Abaalkhail, Almoutaz Hashim, Waleed Al Hamoudi, Mohamed Al Sebayel, Khalid Selim
Journal: Hepat Mon (2013)
Keywords: amputation, gangrene, liver cirrhosis, mucormycosis
MeSH terms: Case Reports

Introduction:
Cutaneous Mucormycosis is a rare opportunistic infection caused by Zygomycetes class of fungi that is often fatal, requiring aggressive local control as well as systemic therapy. Few cases of mucormycosis were described in patients with liver cirrhosis, mostly rhino-orbital. To our knowledge, only two cases of upper extremity involvement was reported in cirrhosis while a few cases were reported in the post-transplant setting. We report herein the third case of upper extremity mucor infection in the setting of liver cirrhosis.
Case presentation:
We described a rare case of forearm infection originating in a traumatic intravenous access portal in a 25 year-old woman with liver cirrhosis secondary to autoimmune hepatitis.
Discussion:
She developed acute on chronic liver failure during the last trimester of pregnancy, which was terminated. Painful, erythematous lesion was noted on her right forearm in the area of intravenous access, which later became necrotic. Extensive debridement was done and histopathological examination confirmed the diagnosis of mucormycosis. The patient started on Amphotericin B. Her condition continued to deteriorate and ended up with above elbow amputation followed by right shoulder disarticulation. She died two days later due to multi-organ failure. In conclusion, forearm mucromycosis in liver cirrhosis can be fatal.
A case of emergent operation for a life-threatening infectious mediastinal cyst
Authors: Daisuke Taniguchi, Tomoshi Tsuchiya, Keitaro Matsumoto, Takuro Miyazaki, Go Hatachi, Koichi Tomoshige, Ryoichiro Doi, Hironosuke Watanabe, Yoshiaki Zaizen, Junya Fukuoka, Takeshi Nagayasu
Journal: Int J Surg Case Rep (2019)
Keywords: bronchogenic cyst, emergent operation, mediastinal tumor

Purpose:
Congenital mediastinal cysts are an uncommon but important diagnostic group. Most of these cysts are benign and asymptomatic in adults. However, some of them are clinically problematic due to the compression of neighboring organs, infection, or perforation.
Case presentation:
A 20-year-old man presented with severe dyspnea. Imaging revealed a mediastinal cyst in the subcarinal space compressing his right pulmonary artery and airway, which was later diagnosed as a bronchogenic cyst. Due to quick symptom exacerbation, emergent cyst wall fenestration was performed through video-assisted thoracic surgery with "stand-by" extracorporeal membrane oxygenation. Complete cyst resection was difficult owing to adhesion of the cyst to the surrounding organs. The symptoms immediately resolved after surgery and the postoperative course was uneventful.
Conclusion:
Mediastinal bronchogenic cysts with life-threatening complications are rarely reported in adults. However, this case was life-threatening due to airway and vascular compression; emergent surgical care should be considered in such cases.
Rapid Progression of Angioimmunoblastic T Cell Lymphoma Following BNT162b2 mRNA Vaccine Booster Shot: A Case Report
Authors: Serge Goldman, Dominique Bron, Thomas Tousseyn, Irina Vierasu, Laurent Dewispelaere, Pierre Heimann, Elie Cogan, Michel Goldman
Journal: Front Med (Lausanne) (2021)
Keywords: covid-19, t cell, angioimmunoblastic, follicular, lymphoma, mrna vaccine
MeSH terms: Case Reports

Since nucleoside-modified mRNA vaccines strongly activate T follicular helper cells, it is important to explore the possible impact of approved SARS-CoV-2 mRNA vaccines on neoplasms affecting this cell type. Herein, we report and discuss unexpected rapid progression of lymphomatous lesions after administration of a BNT162b2 mRNA vaccine booster in a man recently diagnosed with AITL.
Management of Psychosis in a Patient with Probable Dopa-Responsive Dystonia
Authors: Maggie Wang, Joseph I Sison
Journal: Case Rep Psychiatry (2018)
MeSH terms: Case Reports

Dopa-responsive dystonia is a rare childhood neurological disorder characterized by asymmetric dystonia, predominantly of the lower limb, that responds excellently to levodopa replacement therapy. Although it is known that behavioral changes, such as depression, anxiety disorders, and sleep disturbances, typically follow onset of motor symptoms, there is limited literature on the psychiatric symptoms of this disorder. This report describes a novel case of a 20-year-old male with a history of dopa-responsive dystonia and schizoaffective disorder who presented with both dystonia and psychosis after a period of medication noncompliance. This case provides a reference for the management of psychosis in patients with dopa-responsive dystonia and highlights the need for more research on the nonmotor symptoms that accompany this neurological disorder.
Case Report: Metagenomic Next-Generation Sequencing Confirmed a Case of Central Nervous System Infection With Brucella melitensis in Non-endemic Areas
Authors: Jun Cao, Qingqing Cai, Wentao Su, Zi Ge, Hui Zhao, Xinjian Zhou, Ke Ma, Zhijie Xia
Journal: Front Med (Lausanne) (2021)
Keywords: brucella melitensis, central nervous system infection, doxycycline, metagenomic next-generation sequencing, rifampin
MeSH terms: Case Reports

Brucellosis is a highly contagious zoonotic disease caused by bacteria that belong to the genus Brucella. It is a major endemic disease in northern China. We reported a rare case of central nervous system (CNS) infection caused by Brucella melitensis in a patient living in non-endemic areas. The medical history of the patient included chronic headache and trunk numbness. Based on the presented clinical symptoms and medical examinations, a clinical diagnosis of binocular uveo-encephalitis was made in the local hospital. The patient's symptoms were unrelieved after being treated with empiric therapy. Soon after, the patient was admitted to our hospital because of the obnubilation and coma in the trip. We ran a few examinations and sent the cerebrospinal fluid (CSF) for metagenomic next-generation sequencing (mNGS) immediately. The Magnetic resonance imaging (MRI) examination was unremarkable, and bilateral mastoid inflammation was attached. Metagenomic next-generation sequencing suggested a CNS infection caused by Brucella melitensis. Then, the results of the serum agglutination test and quantitative polymerase chain reaction assay also confirmed that. After being treated with doxycycline, rifampin, and cefatriaxone, consciousness of the patient was restored and headache diminished. Two months later, a lumbar puncture was used to check the pressure of the CSF, and the total course of treatment was more than 6 months. This case highlighted the potential value of mNGS in early clinal diagnosis. We believe that mNGS may be a complementary method for rapid identification of infection of CNS caused by the pathogen.
Lacrimal Drainage System Obstruction Following Inferior Turbinate Surgery
Authors: Hirohiko Tachino, Hiromasa Takakura, Hideo Shojaku, Michiro Fujisaka, Chiharu Fuchizawa, Atsushi Hayashi
Journal: Front Surg (2020)
Keywords: ct-dacrocystography, complication of inferior turbinate surgery, location of obstruction, marsupialization, nasolacrimal drainage system
MeSH terms: Case Reports

Objective: To provide information on the clinical characteristics and management of an uncommon acquired nasolacrimal drainage system obstruction (NLDSO). Methods: A patient was treated with microdebrider-assisted endoscopic marsupialization for a cystic lesion located in the synechiae between the inferior turbinate and the lateral wall of the inferior meatus. Results: A 21-year-old woman suffered from epiphora and purulent discharge 1 week after inferior turbinate surgery. Endoscopy reveled synechiae between the inferior turbinate and the lateral wall of the inferior meatus. Computed tomography-dacrocystography (CT-DCG) showed enlargement of the nasolacrimal duct and cystic accumulation of contrast medium from the lacrimal orifice posteriorly. The patient was treated with nasal endoscopic marsupialization of the cyst and then powered inferior turbinoplasty. Six months after the operation, both endoscopy and CT scan showed a widely patent left inferior meatus and nasolacrimal orifice. Conclusions: We report the first case of post-operative NLDSO following inferior turbinate surgery. Nasal endoscopy and CT-DCG are useful to diagnose the location of a NLDSO. Otorhinolaryngologists should be aware that surgery may lead to the formation of a NLDSO and that endoscopic marsupialization is a curative treatment for these distal-end NLDSO. NLDSOs are caused by synechiae, which are a complication of inferior turbinate surgery.
Ag-YOLO: A Real-Time Low-Cost Detector for Precise Spraying With Case Study of Palms
Authors: Zhenwang Qin, Wensheng Wang, Karl-Heinz Dammer, Leifeng Guo, Zhen Cao
Journal: Front Plant Sci (2021)
Keywords: ncs2, yolo, embedded ai, object detection, precise spraying

To date, unmanned aerial vehicles (UAVs), commonly known as drones, have been widely used in precision agriculture (PA) for crop monitoring and crop spraying, allowing farmers to increase the efficiency of the farming process, meanwhile reducing environmental impact. However, to spray pesticides effectively and safely to the trees in small fields or rugged environments, such as mountain areas, is still an open question. To bridge this gap, in this study, an onboard computer vision (CV) component for UAVs is developed. The system is low-cost, flexible, and energy-effective. It consists of two parts, the hardware part is an Intel Neural Compute Stick 2 (NCS2), and the software part is an object detection algorithm named the Ag-YOLO. The NCS2 is 18 grams in weight, 1.5 watts in energy consumption, and costs about $66. The proposed model Ag-YOLO is inspired by You Only Look Once (YOLO), trained and tested with aerial images of areca plantations, and shows high accuracy (F1 score = 0.9205) and high speed [36.5 frames per second (fps)] on the target hardware. Compared to YOLOv3-Tiny, Ag-YOLO is 2× faster while using 12× fewer parameters. Based on this study, crop monitoring and crop spraying can be synchronized into one process, so that smart and precise spraying can be performed.
Primary Sjögren's Syndrome Accompanied by Clinical Features of TAFRO Syndrome
Authors: Eiji Suzuki, Takuya Ichimura, Satoru Kimura, Takashi Kanno, Kiyoshi Migita
Journal: Case Rep Rheumatol (2020)
MeSH terms: Case Reports

Sjögren's syndrome (SS) is associated with not only sicca symptoms but also various symptoms caused by extraglandular manifestation. The pathophysiology and comorbidities of TAFRO syndrome (thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly), which is thought to be a variant of multicentric Castleman's disease, are not fully understood, and there are few data on the effectiveness of treatments. We report a patient of SS with TAFRO syndrome-like clinical features. A 52-year-old woman was admitted to our hospital because of abdominal distension. Laboratory data showed thrombocytopenia, and image findings showed massive ascites without evidence of malignant disease as confirmed by cytology. She was diagnosed with SS based on dysfunction of salivary secretion and positivity for anti-Ro/SS-A and La/SS-B antibodies, accompanied by clinical features of TAFRO syndrome based on the presence of anasarca and thrombocytopenia. High-dose corticosteroid for inflammation, anasarca, and thrombocytopenia was not effective. Cyclosporine was administered next, but anasarca and thrombocytopenia did not immediately improve until tolvaptan and eltrombopag were added. Although tolvaptan and eltrombopag were used for only a few months, the patient maintained a good condition with cyclosporine and low-dose prednisolone. In SS patients, activation of antigen-specific T lymphocytes is thought to be an important trigger that accelerates the immune response and is followed by hypercytokinemia. Therefore, using cyclosporine to suppress the activity of T lymphocytes is a reasonable treatment for SS accompanied with TAFRO syndrome-like pathophysiology. It might also be useful to administer tolvaptan or eltrombopag before the effects of immunosuppressants appear. If refractory inflammation with anasarca, thrombocytopenia, or lymphadenopathy is observed in an SS patient, complications with TAFRO syndrome-like pathophysiology should be considered.
Thyroid Lymphoma as a Cause of Dysphagia and Dyspnea in a Patient without Palpable Nodules or Goiter
Authors: Jarrod D Frizzell, Brandon J Perkins, R Scott Morehead
Journal: Case Rep Med (2009)
MeSH terms: Case Reports

Tumors originating in the neck are well-known causes of progressive dysphagia and dyspnea (including stridor), and thyroid lymphoma is an uncommon example. Physical examination provides an important first step in the evaluation of such complaints, as tumors large enough to produce such symptoms are typically considered to be palpable, if not able to be seen grossly. In this case presentation, the authors describe a nonsubsternal thyroid lymphoma measuring 3 x 4 cm at its largest diameter, producing dysphagia and leading to respiratory emergency, that was entirely nonpalpable to physical exam even after confirmation of its presence by computed tomography.
Is CT or FDG-PET more useful for evaluation of the treatment response in metastatic HER2-positive breast cancer? a case report and literature review
Authors: Hirotaka Suto, Yumiko Inui, Atsuo Okamura
Journal: Front Oncol (2023)
Keywords: ct, fdg-pet, her2, recist, breast cancer, liver metastasis
MeSH terms: Case Reports

Response evaluation criteria in solid tumors version 1.1 (RECIST ver1.1) has been widely adopted to evaluate treatment efficacy in solid tumors, including breast cancer (BC), in clinical trials and clinical practice. RECIST is based mainly on computed tomography (CT) images, and the role of fluorodeoxyglucose-positron emission tomography (FDG-PET) is limited. However, because the rate of tumor shrinkage on CT does not necessarily reflect the potential remaining tumor cells, there may be a discrepancy between the treatment response and prognosis in some cases. Here we report a case of metastatic human epidermal growth factor receptor 2 (HER2)-positive BC where FDG-PET was preferable to CT for evaluation of the treatment response. A 40-year-old woman became aware of a lump in her right breast in September 201X. She was pregnant and underwent further examinations, including a biopsy, in November. The diagnosis was HER2-positive BC (cT2N2bM1, stage IV). Trastuzumab plus pertuzumab plus docetaxel (TPD) therapy was initiated in December 201X. CT performed in February 201X+1 showed cystic changes in the metastatic lesions in the liver, and the treatment response was stable disease (SD) according to RECIST. However, FDG-PET in March 201X+1 did not detect abnormal uptake of FDG in the hepatic lesions. The disease remained stable thereafter. Thus, tumor shrinkage may not be apparent in situations where the response to treatment results in rapid changes in blood flow within the tumor, which is associated with cystic changes. When patients with hypervascular liver metastases receive treatment with highly effective regimens, the target lesion may show cystic changes rather than shrinkage, as observed in the present case. Therefore, FDG-PET is sometimes superior to CT in judging a tumor response.
Arteriovenous malformation of the oral cavity
Authors: S M Manjunath, Sujan Shetty, Ninad J Moon, Bhushan Sharma, Kiran Kumar Metta, Nitin Gupta, Sandeep Goyal, Simranjit Singh
Journal: Case Rep Dent (2014)

Vascular anomalies are a heterogeneous group of congenital blood vessel disorders more typically referred to as birthmarks. Subcategorized into vascular tumors and malformations, each anomaly is characterized by specific morphology, pathophysiology, clinical behavior, and management approach. Hemangiomas are the most common vascular tumors. Lymphatic, capillary, venous, and arteriovenous malformations make up the majority of vascular malformations. Arteriovenous malformation of the head and neck is a rare vascular anomaly but when present is persistent and progressive in nature and can represent a lethal benign disease. Here we present a case report of a 25-year-old male patient with arteriovenous malformation involving the base of tongue.