OpenMed/multicare-articles huggingface dataset:
Drug-Induced Acute Interstitial Nephritis with Nifedipine
Authors: Léonard Golbin, Thibault Dolley-Hitze, Nolwenn Lorcy, Nathalie Rioux-Leclercq, Cécile Vigneau
Journal: Case Rep Nephrol (2016)

Background. Acute interstitial nephritis (AIN) is a frequent cause of Acute Kidney Injury (AKI). Drug hypersensitivity is the most common etiology and the list of drugs that can induce AIN is not exhaustive yet. Case Report. Here, we describe the case of a 43-year-old man who was treated with nifedipine (Adalate®) for Raynaud's syndrome. After nifedipine introduction, serum creatininemia progressively increased from 91 to 188 μmol/L in a few months and AKI was diagnosed. Laboratory work-up results indicated the presence of tubular proteinuria and nonspecific inflammatory syndrome. Histological analysis found granulomatous interstitial nephropathy without necrosis in 20% of the kidney biopsy without immunofluorescent deposit. Nifedipine was stopped and corticosteroid treatment was started with a rapid but incomplete reduction of serum creatininemia level to 106 μmol/L. Conclusion. This is the first case of AIN caused by nifedipine.
Management of external invasive cervical resorption tooth with mineral trioxide aggregate: a case report
Authors: Anuja Ikhar, Nikita Thakur, Aditya Patel, Rohan Bhede, Pranav Patil, Surbhi Gupta
Journal: Case Rep Med (2013)

Invasive cervical resorption is entirely uncommon entities and the etiology is poorly understood. A 19 year old patient presented with fractured upper left central incisor and sinus tract opening on the distobuccal aspect in cervical region. Radiographic examination shows irregular radiolucency over the coronal one-third and it extended externally towards the external invasive resorption. After sectional obturation, the defect was accessed surgically. The resorption area was chemomechanically debrided using irrigant solution. Fibre post placement using flowable composite resin and Mineral Trioxide Aggregate (MTA) was used to fill the resorptive defect, and the coronal access was temporarily sealed. Composite restoration was subsequently replaced with ceramic crown after 4 years. Radiographs at 1 and 4 years showed adequate repair of the resorption and endodontic success. Clinically and radiographically the tooth was asymptomatic, and no periodontal pocket was found after a 4-year followup.
Clinical Features, Diagnosis, and Treatment of Primary Intraventricular Lymphoma: Insights From a Monocentric Case Series
Authors: Lidong Cheng, Hongtao Zhu, Jing Wang, Guanghui Wang, Xiaoyu Ma, Kai Zhao, Junwen Wang, Kai Shu
Journal: Front Neurol (2022)
Keywords: case reports, clinical features, diagnosis, intraventricular, primary central nervous system lymphoma, review, treatment

Objective:
Primary ventricular lymphoma (PVL) is an extremely rare and commonly misdiagnosed disease. Previous studies were predominantly case reports, and literature regarding the diagnosis and treatment of PVL is limited. Therefore, this study aimed to evaluate the characteristics of patients with PVL.
Methods:
The data of patients with pathologically confirmed PVL were assessed. Epidemiological data, imaging findings, surgery, pathological results, and prognosis were retrospectively analyzed. A systematic review of relevant literature was also conducted.
Results:
A total of eight patients with PVL were identified. The main symptom was increased intracranial pressure. Radiographically, five patients had single lesion and three had multiple lesions; typical findings on magnetic resonance imaging included hypointensity on T1- and T2-weighted imaging, adjacent brain edema, and homogeneous enhancement on contrast-enhanced T1-weighted images. Preoperatively, six cases were misdiagnosed and two cases did not get a definite diagnosis. Craniotomy was performed on all patients, and four achieved gross total resection. Hydrocephalus was relieved after surgical resection in four patients. Pathology revealed diffuse large B-cell lymphoma in all patients. Only one patient had a severe complication. A total of three patients received concomitant adjuvant treatment, whereas five patients refused any adjuvant therapy. At the time of follow-up, the median survival time of patients was 15 months.
Conclusion:
Primary ventricular lymphoma mainly presented with symptoms of increased intracranial pressure and had several imaging characteristics for the diagnosis, but the condition still tends to be misdiagnosed. Surgical resection is a feasible treatment for patients with isolated nodules, especially those with acute obstructive hydrocephalus.
Rapidly progressive glomerulonephritis in two Zambian children: a case report
Authors: Chisambo Mwaba, Chibamba Ngomalala Mumba, Musyani Simukonde, Somwe Wa Somwe
Journal: Pan Afr Med J (2022)
Keywords: acute kidney injury, case report, crescentic glomerulonephritis, rapidly progressive glomerulonephritis, renal disease
MeSH terms: Glomerulonephritis / diagnosis, Glomerulonephritis / therapy, Case Reports, Child, Creatinine, Disease Progression, Humans, Kidney / pathology, Zambia, Creatinine

Rapidly progressive glomerulonephritis (RPGN) is a rare syndrome which is marked by a sudden rise in serum creatinine and the presence of crescents on renal biopsy. If appropriate and timely treatment is not instituted, as many as 90% of affected patients may develop End Stage Renal Disease (ESRD). There is only limited access to renal replacement therapy in many low resource countries, thus it is important that awareness of this entity is raised. We narrate the clinical course of two children who were admitted with rising serum creatinine, hypertension and haematuria and who were subsequently diagnosed with crescentic glomerulonephritis on biopsy. Despite having received immunosuppressive therapy, both children had a poor renal outcome, perhaps due to delays in institution of appropriate treatment. It is imperative that all clinicians who manage children are made aware of this clinical syndrome so that timely referrals to nephrology are done. This will help to improve renal outcomes.
Gastrosplenic Fistula without Malignancy Management in a 16-Year-Old Boy
Authors: Aila Malik, Chinwendu Onwubiko, Mike Chen, Andrei Radulescu, David Galloway, Colin Martin
Journal: European J Pediatr Surg Rep (2019)
Keywords: gastrosplenic fistula, pancreatitis, splenic infarct, subtotal gastrectomy
MeSH terms: Case Reports

Gastrosplenic fistula is a very rare entity, most commonly occurring as a distinctive complication of splenic or gastric malignancies, most notably diffuse large B cell lymphoma (DLBCL). Benign gastric ulcer, splenic abscess, and Crohn's disease have also been reported as possible causes. We report a nonmalignant case of 16-year-old male with a gastrosplenic fistula of unclear etiology. The fistulous tract was confirmed by an upper endoscopy and an upper gastrointestinal series. Subsequently, it was surgically managed with a subtotal gastrectomy with "Roux-en-Y" reconstruction and a feeding jejunostomy.
Multiple Micronodular Pneumocyte Hyperplasia (MMPH): A Less-Known Presentation of Tuberous Sclerosis Complex Related Lung Disease
Authors: Matthias Lembrechts, Adriana Dubbeldam
Journal: J Belg Soc Radiol (2023)
Keywords: mmph, multiple micronodular pneumocyte hyperplasia, tsc, tuberous sclerosis complex, ground glass nodule
MeSH terms: Case Reports

Teaching Point: Multiple micronodular pneumocyte hyperplasia (MMPH) is a less-known presentation of tuberous sclerosis complex (TSC) associated lung disease that usually requires no treatment or follow-up imaging.
Iridociliary melanoma - Clinical case
Authors: S Schmitzer, C Butea-Simionescu, A Gheorghe, M Zemba, M Cioboata
Journal: J Med Life (2016)
Keywords: iridocyclectomy, melanoma, surgery
MeSH terms: Ciliary Body / surgery, Iris Neoplasms / surgery, Melanoma / surgery, Uveal Neoplasms / surgery, Case Reports, Female, Humans, Middle Aged, Surgical Flaps, Uveal melanoma

Iris and ciliary body melanoma is an aggressive tumor, which, unfortunately, presents symptoms only in advanced stages and is often discovered accidentally during a routine eye examination. There are several treatment options, ranging from in time monitorization in order to observe the tumor's evolution to more aggressive methods such as radiotherapy and enucleation. We present a case of iridociliary melanoma, who underwent conservative surgery, iridocyclectomy under scleral flap, with good results, and maintenance of the function and integrity of the eyeball.
Direct carotid-cavernous fistula: an atypical presentation
Authors: Yousra Ajhoun, Adil El Khoyali, Ismail Aissa, Nisrine Laaribi, Yassine Mouzari, Karim Reda, Abdelbarre Oubaaz
Journal: Pan Afr Med J (2019)
Keywords: direct carotid-cavernous fistula, craniofacial trauma, insidious onset
MeSH terms: Carotid-Cavernous Sinus Fistula / diagnosis, Craniocerebral Trauma / complications, Exophthalmos / etiology, Case Reports, Adult, Carotid-Cavernous Sinus Fistula / complications, Humans, Male

Posttraumatic carotid-cavernous fistula (CCF) is a very rare complication that can occur in patients with craniomaxillofacial trauma. It is defined by abnormal communication between arteries and veins located in the cavernous sinus. CCFs can be divided into two groups: direct, which are usually post traumatic and classically with a high flow and acute onset of symptoms. On the other hand, indirect CCFs are in the most of cases idiopathic and typically insidious of onset. The aim of the present case report is to describe an atypical presentation of direct CCF characterized by the insidious onset of symptoms with the goal to think about this rare complication and so not to delay the treatment which is an emergency in this case.
Case report: An ectopic adrenocortical adenoma in the renal sinus
Authors: Tianyu Liu, Renguang Lv, Xiaolin Hu, Kewei Li, Qiangqiang Ren, Yongzhen Zhang, Liwei Meng, Zhaoxu Liu, Zhaoxin Guo, Yufeng Cheng
Journal: Front Oncol (2022)
Keywords: adrenocortical adenoma, ectopic, kidney, laparoscopic surgery, nonfunctional adenomakidney, renal sinus mass
MeSH terms: Case Reports

Background:
Ectopic adrenal tissue is rare in adults, with an incidence of only about 1%. We report a rare case of ectopic adrenocortical adenoma in the left renal sinus.
Case preentation:
A 57-year-old woman was admitted to the Department of Urology due to "a left kidney tumor" on physical examination. Multislice helical computed tomography (CT) showed the left kidney with an anterior lip mass near the hilum, approximately 2.3 cm × 2.2 cm in size. Preoperative renal artery CT angiography (CTA) showed no obvious abnormality. Laparoscopic resection of the left renal sinus mass was performed, and postoperative pathological findings showed ectopic adrenocortical adenoma. The tumor was a nonfunctional adenoma.
Conclusion:
Renal ectopic adrenal cortical adenoma is rare. Most of them are nonfunctional adenomas, which cannot be clearly diagnosed by preoperative imaging examination and can often be diagnosed by postoperative pathology.
Severe type-B lactic acidosis in a patient with bilateral renal Burkitt's lymphoma
Authors: Juan D Salcedo Betancourt, Oscar A Garcia Valencia, Victor G Becerra-Gonzales, Karla G Carias Martinez, Jennifer Chapman, Natalia Yanchenko, Marco A Ladino
Journal: Clin Nephrol Case Stud (2021)
Keywords: burkitt’s lymphoma, kidney neoplasms, lactic acidosis, non-hodgkin lymphoma

Introduction:
Lactic acidosis (LA) can be categorized as type A, which occurs in the presence of tissue hypoxia, or type B, occurring in the absence of tissue hypoxia. Hematologic malignancies are an uncommon cause of type B LA.
Case presentation:
A 63-year-old man, HIV-negative, with a history of diabetes mellitus, hypothyroidism, and non-alcoholic fatty liver disease (NAFLD), presented to the ED complaining of acute-on-chronic lumbar pain, and was found to have high serum anion gap (AG) LA. The rest of chemistry and infectious workup was within normal limits. Despite bicarbonate therapy and fluid resuscitation, the patient remained with persistent AG metabolic acidosis and increasing lactic acid up to 14.5 mmol/L. An abdominal computerized tomography (CT) revealed multiple bilateral enhancing lesions in the kidneys, as well as gastric wall thickening. Upper gastrointestinal endoscopy with biopsy showed a high-grade Burkitt's lymphoma. Further staging showed bone marrow involvement and extensive abdominal adenopathy. After two cycles of inpatient chemotherapy with dose-adjusted EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin and rituximab), the patient developed multifocal pneumonia complicated by respiratory failure. Following a prolonged ICU stay, after discussion with the family members, a decision of withdrawal of life-sustaining therapy was reached.
Conclusion:
Persistent LA, without identifiable causes of tissue hypoxia, should prompt clinicians to suspect non-hypoxic etiologies, including occult high-grade malignancies. Hematological malignancies constitute an extremely rare cause of type-B LA, carrying a poor prognosis.
Aborted Sudden Cardiac Death in a Female Patient Presenting with Takotsubo-Like Cardiomyopathy due to Epicardial Coronary Vasospasm
Authors: Sorin Giusca, Tom Eisele, Peter Nunninger, Benedikt Münz, Grigorios Korosoglou
Journal: Case Rep Cardiol (2017)
MeSH terms: Case Reports

Takotsubo cardiomyopathy is characterized by apical ballooning of the left ventricle (LV) in the absence of relevant coronary artery stenosis, which typically occurs in elderly women after emotional stress. Catecholamine cardiotoxicity, metabolic disturbance, and coronary microvascular impairment have previously been proposed as underlying pathophysiologic mechanisms of takotsubo cardiomyopathy, whereas myocardial stunning resulting from epicardial coronary artery vasospasm is not generally accepted as a cause of takotsubo cardiomyopathy. The prognosis of takotsubo cardiomyopathy is generally more favourable compared to myocardial infarction; however, severe complications such as rupture of the LV and life-threatening arrhythmias may occur. Herein, we describe a case of an 84-year-old female, who presented with aborted sudden cardiac death due to ventricular fibrillation. Echocardiography suggested LV apical ballooning with severely impaired LV-function, so that takotsubo cardiomyopathy was suspected. However, coronary angiography revealed epicardial spasm of the left anterior ascending, which resolved after intracoronary injection of 0.2 mg nitroglycerine. Cardiac magnetic resonance exhibited subendocardial late enhancement and echocardiography showed normalization of LV dysfunction during follow-up. The patient was put on conservative treatment with nitrates and calcium inhibitors and ICD implantation were deferred.
Ultrasonographic diagnosis of bilateral partial rupture of the infraspinatus muscle in a racing greyhound
Authors: Maria Ligia de Arruda Mestieri, Bruna Gonzalez Dos Santos, Mayara Nóbrega Gomes da Silva, João Paulo da Exaltação Pascon, Leandro Ziemer Carneiro
Journal: Braz J Vet Med (2021)
Keywords: dog, muscle injury, orthopedics, sports, ultrasonography
MeSH terms: Case Reports

Athletic dogs are more susceptible to musculoskeletal disorders, especially in the muscles or tendons surrounding the shoulder joint. In this report, we describe a case of partial bilateral rupture of the infraspinatus muscle, an unusual injury. Clinical signs included lameness of the left thoracic limb after training. On physical examination, there was discomfort on bilateral palpation in the infraspinatus fossa region. The main clinical suspicion was partial rupture or myositis of the infraspinatus muscle (IF). Ultrasound examination of the region revealed the presence of hypoechoic areas intermingling the muscle fibers in a deeper and distal region of the infraspinatus muscle, compatible with edema or bilateral intramuscular hematoma (left +++, right ++) and integrity of the fascia. The findings were characterized as a partial rupture of the musculature. A detailed physical examination associated with ultrasound examination is essential for early diagnosis and therapeutic management. Although no other reports of partial rupture of the IF have been found, partial or complete rupture of muscle fibers in sport dogs is frequent. Early diagnosis prevents the development of contractures due to the institution of therapy before the fibrous process is established and improves prognosis.
Intravenous leiomyoma with extension to the heart: a case report and review of the literature
Authors: Fuat Demirkiran, Veysel Sal, Umit Kaya, Cem Alhan, Nedim Tokgozoglu
Journal: Case Rep Obstet Gynecol (2013)
MeSH terms: Retracted Publication

Introduction. Intravenous leiomyomatosis with cardiac extension is an extremely rare uterine tumor. We report here a case of intravenous leiomyoma extending to the right atrium, diagnosed in a patient having leiomyoma. Case Presentation. A 39-year-old woman with no symptoms and a past medical history of two myomectomy operations (7 and 3 years previously) was admitted to our clinic for routine control. We detected a uterine fibroid of 8 centimeters and 4 small solid masses of 1-2 centimeters near the uterus and ovaries at vaginal ultrasonography. Computed tomography (CT) was performed to investigate the abdominal cavity. It revealed a mass originating from the left common iliac vein, which invaded the inferior vena cava (IVC) and extended to the right atrium in addition to the uterine fibroids and pelvic masses. The operation was performed with a combined team of gynecologists and cardiac surgeons and a one-stage operation was accomplished. The postoperative course was uneventful. Conclusion. Abdominal CT is a useful imaging technique for the diagnosis of unusual pathology in a patient with uterine fibroid having suspicious pelvic masses. Also, when a right atrial mass is identified in a female with a prior history of hysterectomy because of leiomyoma or in whom there is a uterine myoma, then intravenous leiomyomatosis should be considered.
Adenocarcinoma of the Right Colon in a Patient with Bloom Syndrome
Authors: Carlos Augusto Real Martinez, Lilian Vital Pinheiro, Debora Helena Rossi, Michel Gardere Camargo, Maria de Lourdes Setsuko Ayrizono, Raquel Franco Leal, Cláudio Saddy Rodrigues Coy
Journal: Case Rep Surg (2016)

Introduction. Bloom syndrome (BS) is an inherited disorder due to mutation in BLM gene. The diagnosis of BS should be considered in patients with growth retardation of prenatal onset, a photosensitive rash in a butterfly distribution over the cheeks, and an increased risk of cancer at an early age. Clinical manifestations also include short stature, dolichocephaly, prominent ears, micrognathia, malar hypoplasia and a high-pitched voice, immunodeficiency, type II diabetes, and hypogonadism associated with male infertility and female subfertility. The aim of this report is to describe case of patient with BS who developed adenocarcinoma of the cecum, successfully treated by right colectomy. Case Report. A 40-year-old man underwent colonoscopy to investigate the cause of his diarrhea, weight loss, and anemia. The patient knew that he was a carrier of BS diagnosed at young age. The colonoscopy showed an expansive and vegetating mass with 5.5 cm in diameter, located within the ascending colon. Histopathological analysis of tissue fragments collected during colonoscopy confirmed the presence of tubular adenocarcinoma, and he was referred for an oncological right colectomy. The procedure was performed without complications, and the patient was discharged on the fifth postoperative day. Histopathological examination of the surgical specimen confirmed the presence of a grade II tubular adenocarcinoma (stage IIA). The patient is currently well five years after surgery, without clinical or endoscopic signs of relapse in a multidisciplinary approach for the monitoring of comorbidities related to BS. Conclusion. Despite the development of colorectal cancer to be, a possibility rarely described the present case shows the need for early screening for colorectal cancer in all patients affected by BS.
Isolated endogenous Nocardia endophthalmitis after immunosuppression
Authors: Lisa Y Chen, Muge R Kesen, Abdalhossein Ghafourian, Quan D Nguyen, Charles G Eberhart, Diana V Do
Journal: J Ophthalmic Inflamm Infect (2012)

Purpose:
This study is aimed to report a case of endogenous Nocardia endophthalmitis in the setting of immunosuppression from chronic steroid use.
Methods:
A case report was conducted.
Results:
A 79-year-old woman presented with decreased vision with floaters in the left eye. Ophthalmic examination revealed severe inflammation in the anterior chamber, vitreous opacities, and retinal detachment. Vitreous cultures grew Nocardia farcinica without any systemic foci of infection found during further workup. The patient was treated with intravitreal amikacin and oral trimethoprim-sulfamethoxazole, and her retinal detachment was later repaired in the operating room. The patient has since remained stable with no signs of retinal detachment or active infection.
Conclusions:
Nocardia endophthalmitis is a rare, but serious intraocular infection that should be considered in the differential diagnosis in any immunosuppressed patient, including those receiving steroids, who presents with signs of intraocular infection.
Uterine leiomyoma associated non-puerperal uterine inversion misdiagnosed as advanced cervical cancer: A case report
Authors: Osita Samuel Umeononihu, Joseph Ifeanyi Adinma, Nworah J Obiechina, George Uchenna Eleje, Onyebuchi Izuchukwu Udegbunam, Ikechukwu Innocent Mbachu
Journal: Int J Surg Case Rep (2013)
Keywords: chronic uterine inversion, gynaecological near miss, misdiagnosed, non-puerperal, tumour

Introduction:
Uterine inversion is an un-common complication of parturition which often occurs in the immediate postpartum period. The chronic (non-puerperal) uterine inversion is rarer and most times tumour associated.
Presentation of case:
A 51-year old grand multiparous lady presented with a month history of abnormal vaginal bleeding associated with offensive vaginal discharge, lower abdominal pain and dizziness. The initial evaluation suggested severe anaemia secondary to advanced cervical cancer. Examination under anaesthesia (EUA), staging and biopsy was attempted but this was however inconclusive due to profuse haemorrhage. A repeat EUA revealed chronic uterine inversion secondary to fundal submucous uterine leiomyoma. Myomectomy was done with tissue histology confirming benign uterine leiomyoma. Two weeks later, a modified Haultain's procedure was done followed by simple hysterectomy and posterior colpoperineorrhaphy. She had satisfactory recovery.
Discussion:
This is the first reported case of chronic non-puerperal uterine inversion in our hospital. When it occurs, it is usually tumour associated with the commonest tumour being prolapsed myoma and leiomyosarcoma. The diagnosis is based on high index of suspicion.
Conclusion:
Chronic uterine inversion is a rare gynaecological condition and can be misdiagnosed as advanced cervical cancer or other causes of severe genital haemorrhage in women. A high index of suspicion is needed for its proper diagnosis. Sometimes, an EUA and biopsy was required to determine the cause here and conveniently it could be described as a "gynaecolological near miss".