OpenMed/multicare-articles huggingface dataset:
Rare Cause of Stricture Esophagus-Sarcoma: A Case Report and Review of the literature
Authors: S Patricia, Das Saikat, B Rajesh, I Rajesh, B Selvamani, John Subhashini
Journal: Case Rep Gastrointest Med (2011)
MeSH terms: Case Reports

Adenocarcinoma and squamous cell carcinoma account for the vast majority of oesophageal malignancies. Other malignancies known to occur in the oesophagus include melanoma, sarcoma, and lymphoma. Among the sarcomas, carcinosarcoma is the commonest with both carcinomatous and sarcomatous elements followed by leiomyosarcoma of mesenchymal origin. Other sarcomas reported in the literature are liposarcoma, synovial sarcoma, myxofibrosarcoma, Ewing's sarcoma, granulocytic sarcoma, histiocytic sarcoma, schwannoma rhabdomyosarcoma, and epithelioid sarcoma. We report a case of malignant spindle cell tumour of oesophagus. Sarcomas of esophagus present as a polypoid exophytic soft tissue mass. Our patient presented with a stricture which is a rare presentation. Locally aggressive treatment with surgery is beneficial, and local palliative treatment including radiotherapy is worthwhile.
Pleomorphic liposarcoma of bone: a rare primary malignant bone tumour
Authors: G L Tiemeier, J M Brown, S E Pratap, C McCarthy, A Kastrenopoulou, K Bradley, S Wilson, Z Orosz, C L M H Gibbons, U Oppermann, N A Athanasou
Journal: Clin Sarcoma Res (2018)
Keywords: bone, liposarcoma, malignant, primary tumour
MeSH terms: Case Reports

Background:
Liposarcoma is an extremely rare primary bone sarcoma.
Case presentation:
We report a case of primary pleomorphic liposarcoma that arose in an 18 year old male in the metaphysis of the left tibia. Plain radiographs showed a partly sclerotic lesion and MR imaging a heterogeneous tumour predominantly isointense on T1- and high-signal on T2-weighted sequences with focal areas of increased T1 signal that suppressed with fat saturation. PET/CT showed marked FDG uptake (SUV = 17.1) in the primary tumour as well as a metastasis in the right distal femur and multiple small pulmonary metastases. Histologically, the tumour was a pleomorphic liposarcoma containing large tumour cells with vacuolated cytoplasm and hyperchromatic pleomorphic nuclei as well as numerous lipoblasts and scattered brown fat-like cells. Tumour cells strongly expressed FABP4/aP2, a marker of adipocyte differentiation, and UCP1, a marker of brown fat, but not S100. The case was treated with neoadjuvant MAP chemotherapy, resulting in extensive (> 95%) necrosis in the primary tumour and almost complete resolution of the femoral and pulmonary metastases.
Conclusions:
Pleomorphic liposarcoma can present as a sclerotic primary malignant bone tumour; markers of adipose differentiation are useful in histological diagnosis and neoadjuvant MAP chemotherapy results in significant tumor necrosis.
Accomplishing dietary and biochemical standards and improving hemodialysis efficiency with a non-compliant patient; a case study
Authors: Chaudhary-Muhammaed Junaid-Nazar, Manzoor A Lala, Saba Izhar, Percy Joesph
Journal: J Renal Inj Prev (2014)
Keywords: diet, end stage renal failure, hemodialysis, renal association standards, renal disease
MeSH terms: Case Reports

Background:
It was not until mid nineties when UK (RAS) and US (K/DOQI) first launched the nutritional and biochemical standards for haemodialysis in patients with ESRF. The present case is related to a patient who's blood results diverged widely from the nutritional and biochemical standards set by the RAS. And how the multidisciplinary team with this patient aimed to achieve these standards.
Case:
A 52-year old, staff nurse presented with end stage renal failure due to polycystic kidney disease with bilateral nephropathy, established on haemodialysis unusual inter-dialytic weight gains, often severe intradialytic cramps and hypotension to the point of being unresponsive. The patient's high weight gain and high serum potassium and phosphate levels led to the patient being labelled non-compliant. Other contributing factors together with weight gains have to be explored.
Conclusion:
Renal health care professionals have guidelines which they can work with their patients. Outside target results should be investigated to ensure that patient receives the right treatment. Treatment modality and prescription have to be individualized according to the patient's needs. Like this case it is worth considering other factors like events in the patient's life cycle, personal, social and economical factors and staff's attitude may contribute to the perceived non-compliance.
Colocolic Intussusception in Children: A Case Series and Review of the Literature
Authors: Jiayu Yan, Qiulong Shen, Chunhui Peng, Wenbo Pang, Yajun Chen
Journal: Front Surg (2022)
Keywords: children, colocolic intussusception, open surgery, pathologic lead point, treatment

Background:
Colocolic intussusception is a rare subtype of intussusception mostly caused by juvenile polyps. The treatment of colocolic intussusception caused by other pathologic lead points in children remains poorly understood.
Method:
A systematic literature review was performed between January 2000 and June 2021 to characterize the comprehensive treatment of colocolic intussusception in children. This report also included patients admitted to our center between January 2010 and June 2021 who were not previously reported in the literature.
Results:
We identified 27 patients in 20 studies in addition to 17 patients from our center for a total of 44 patients (median age, 4.4 years; 52.3% male). The lead point was identified in 40 patients (40/44, 90.9%). The most common lead point was juvenile polyps (19/44, 43.2%). A therapeutic enema was performed in 15 patients with colocolic intussusception caused by juvenile polyps and was successful in 9 patients (9/15, 60.0%). Colonoscopic polypectomy was subsequently performed in 8 patients and was successful in 7 patients (7/8, 87.5%). The other patient had undergone laparoscopic exploration, and no abnormality was found. Subsequently, the patient underwent open surgery. The patients with colocolic intussusception caused by other pathologic lead points almost underwent surgical treatment (15/21, 71.4%), including 13 open surgeries and 2 laparoscopic surgeries.
Conclusion:
A therapeutic enema followed by colonoscopic polypectomy is feasible to treat colocolic intussusception caused by juvenile polyps unless the patient has bowel perforation; however, surgery is sometimes needed. For patients with colocolic intussusception caused by other pathologic lead points, open surgery remains the primary treatment.
Diagnosis and Treatment of Esophageal Granular Cell Tumor: A Case Report and Review of the Literature
Authors: Ramin Niknam, Kamran Bagheri Lankarani, Bita Geramizadeh
Journal: Case Rep Gastrointest Med (2017)
MeSH terms: Case Reports

Gastrointestinal granular cell tumors are uncommon. The most common site of gastrointestinal granular cell tumor (GCT) is esophagus. We report a case of esophageal GCT incidentally diagnosed by endoscopy. The lesion was evaluated by endoscopic ultrasonography and resected using the endoscopic technique without complication.
Actinomyces israelii may produce vulvar lesions suspicious for malignancy
Authors: Jennifer Y McElroy, Marsha E Gorens, Lisa N Jackson, Danielle Stigger, Teresa Becker, Eyal Sheiner
Journal: Infect Dis Obstet Gynecol (2006)
MeSH terms: Actinomyces / pathogenicity, Actinomycosis / diagnosis, Vulvar Diseases / diagnosis, Vulvar Neoplasms / diagnosis, Case Reports, Actinomycosis / microbiology, Actinomycosis / pathology, Diagnosis, Differential, Epidermal Cyst / microbiology, Epidermal Cyst / pathology, Female, Humans, Middle Aged, Vulvar Diseases / microbiology, Vulvar Diseases / pathology, Vulvar Neoplasms / microbiology, Vulvar Neoplasms / pathology

Background:
We present a case of Actinomyces israelii causing vulvar mass suspicious for malignancy in a postmenopausal woman.
Case:
A 60 year-old woman presented due to a firm, nonmobile, 10 cm vulvar mass, which had been rapidly enlarging for 5 months. The mass was painful, with localized pruritus and sinus tracts oozing of serosanguinous fluid. Biopsy and cultures revealed a ruptured epidermal inclusion cyst containing granulation tissue and Actinomyces israelii.
Conclusion:
Actinomyces israelii may produce vulvar lesions that are suspicious for malignancy. Thus, biopsies and cultures are both mandatory while evaluating vulvar masses suspicious for malignancy.
Unilateral glenoid hypoplasia: a case report and review of the literature
Authors: Ashish Suryawanshi, Amber Mittal, Snehal Dongre, Neeti Kashyap
Journal: Case Rep Orthop (2011)
MeSH terms: Case Reports

Glenoid hypoplasia is a relatively rare alteration that in most cases involves the pectoral girdle in a bilateral and symmetrical manner. In general, glenoid hypoplasia is associated with skeletal changes such as hypoplasia of the humeral head or changes in the morphology of the acromion and of the coracoid. We describe a rare case of unilateral glenoid hypoplasia without instability and not involving humeral head. The patient was managed effectively with nonoperative measures that featured specific rehabilitation exercises for the shoulder.
Primary monophasic synovial sarcoma presenting as a pulmonary mass: a case report
Authors: Charalampos M Mermigkis, Antony Kopanakis, George Patentalakis, Vlassis Polychronopoulos, Michael Patentalakis
Journal: J Med Case Rep (2008)

Introduction:
Primary pulmonary synovial sarcoma is an extremely rare tumor with only few case reports in the literature.
Case presentation:
A healthy 67-year-old woman was admitted for investigation of a pulmonary mass found on a routine X-ray. She had a history of breast cancer diagnosed and treated 13 years previously with left mastectomy followed by adjuvant endocrine therapy. No progression of the disease was reported. Thoracic computer tomography disclosed a soft-tissue mass in the lower lobe of the left lung arising in the vicinity of the pleura. No abnormal lymph nodes were noted. Further work-up for metastases was negative. Subsequently, the lower lobe of the left lung was removed and the diagnosis was a monophasic synovial sarcoma.
Conclusion:
The diagnosis of monophasic primary pulmonary synovial sarcoma requires clinical, imaging and immunohistochemical investigation to exclude alternative primary sources. The treatment of choice is excision (lobectomy or pneumonectomy), which in most of cases is helpful for diagnosis. The prognosis is usually poor.
Successful perioperative management of a patient with the left ventricular assist device for brain tumor resection: case report and review of the literature
Authors: Rashmi Vandse, Thomas J Papadimos
Journal: Case Rep Anesthesiol (2015)

Heart failure is the leading cause of death in the United States. Our increasingly aged population will contribute to an increased incidence and prevalence of heart failure, thereby augmenting the need for mechanical circulatory devices. Here we present the first successful resection of a brain tumor in a left ventricular device- (LVAD-) dependent patient with increased intracranial pressure and address pertinent perioperative anesthetic considerations and management.
Arcanobacterium haemolyticum associated with pyothorax: case report
Authors: Subhash Chandra Parija, Venkatesh Kaliaperumal, Saka Vinod Kumar, Sistla Sujatha, Venkateshwara Babu, V Balu
Journal: BMC Infect Dis (2005)
MeSH terms: Actinomycetaceae / isolation & purification, Empyema, Pleural / microbiology, Gram-Positive Bacterial Infections / microbiology, Case Reports, Actinomycetaceae / classification, Adult, Anti-Bacterial Agents / therapeutic use, Empyema, Pleural / pathology, Gram-Positive Bacterial Infections / diagnosis, Gram-Positive Bacterial Infections / drug therapy, Humans, Male, Anti-Bacterial Agents

Arcanobacterium haemolyticum has an established role in the etiology of human pharyngitis. There are increasing reports of systemic infections caused by this organism. From India, we report the first case of Arcanobacterium haemolyticum causing pyothorax in an immunocompetent adolescent male patient. The probable mode of infection is also discussed. The role of A. hemolyticum as an animal pathogen needs further study.
Rare hereditary cause of chronic pancreatitis in a young male: SPINK1 mutation
Authors: Janaki Patel, Arina Madan, Amanda Gammon, Michael Sossenheimer, Niloy Jewel Samadder
Journal: Pan Afr Med J (2017)
Keywords: hereditary pancreatitis, spink1 mutation, atypical presentation, pancreatic malignancy
MeSH terms: Pancreatitis, Chronic / genetics, Renal Colic / diagnosis, Trypsin Inhibitor, Kazal Pancreatic / genetics, Case Reports, Genetic Predisposition to Disease, Genetic Testing, Humans, Incidental Findings, Male, Mutation, Pancreatitis, Chronic / diagnosis, Young Adult, SPINK1 protein, human, Trypsin Inhibitor, Kazal Pancreatic

Hereditary chronic pancreatitis associated with a mutation in the serine protease inhibitor, Kazal Type-1 (SPINK-1 gene) is extremely rare. The SPINK1 mutation results in trypsinogen activation which predisposes to chronic pancreatitis predominately when combined with CFTR gene mutations. It presents as either chronic or recurrent acute pancreatitis. Symptom control and management of complications is important. Active surveillance with cross-sectional imaging for pancreatic malignancy in individuals with hereditary pancreatitis is advocated due to individuals being high risk. We present an unusual case of a young male who initially presented with renal colic and was incidentally diagnosed with severe chronic pancreatitis on abdominal imaging, with genetic testing confirming a homozygous SPINK1 mutation.
Primary Squamous Cell Carcinoma, a Rare Pathological Report of Pancreatic Cancer
Authors: Pegah Farokhi, Alireza Sadeghi, Azadeh Moghaddas, Mitra Heidarpour, Saman Dinari
Journal: Caspian J Intern Med (2021)
Keywords: carcinoma, chemotherapy, pancreatic cancer, primary squamous cell, survival
MeSH terms: Case Reports

Background:
Primary squamous cell carcinoma (SCC) of the pancreas is a rare tumor and associated with poor prognosis. The diagnosis and optimal management of patients is still a matter of debate and not well-defined. Limited chemotherapy protocols, radiotherapy and surgical resection of the tumor were proposed for the management of patients suffering from SCC of the pancreas.
Case presentation:
In this report, we introduced a 57-year-old man who was diagnosed with SCC of the pancreas along with liver metastasis. The patient underwent surgical resection and several adjuvant systemic chemotherapies including fluorouracil and taxane based regimens which were led to the 13- month overall survival.
Conclusion:
Although, the patients died from underlying tumor, the survival time before death was one of the longest time/period reported.
Interstitial Mycosis Fungoides: An Unusual Mimic of Interstitial Granuloma Annulare Not to Miss
Authors: Neha Singh, Kiley K Fagan, Douglas J Grider
Journal: Case Rep Dermatol Med (2022)
MeSH terms: Case Reports

Interstitial mycosis fungoides is a rare histopathologic variant of mycosis fungoides that may resemble interstitial granuloma annulare, inflammatory morphea, and interstitial granulomatous dermatitis. Reported is a case of a 62-year-old African American female who presented with an asymptomatic, progressive rash of the left underarm and abdomen with histologic features suggestive of granuloma annulare. Biopsies revealed an interstitial pattern of cells in the dermis with prominent small aggregates of atypical lymphocytes, a few atypical lymphocytes in the lower epidermis, and a mild increase in dermal mucin. Immunohistochemistry staining revealed the atypical lymphocytes to be positive for CD3 and CD8 and negative for CD4 and CD7, an aberrant immunoprofile. Mixed in the dermis with the atypical lymphoid cells were a few CD68 positive histiocytes and S100 protein positive dermal dendritic cells. T-cell receptor beta gene rearrangement studies showed nearly the same clonal peaks for TCRB rearrangement in two biopsy specimens from separate sites, all supporting a diagnosis of interstitial mycosis fungoides. The patient is undergoing treatment with full body narrowband UVB (nbUVB) phototherapy with notable improvement in skin discoloration and resolution of several abdominal lesions. A diagnosis of interstitial mycosis fungoides is challenging to make based on clinical features alone and is often clinically misdiagnosed. Awareness of histopathologic features is critical to make an accurate diagnosis and thus patient management.
Locked-In Syndrome after Traumatic Basilar Artery Entrapment within a Clivus Fracture: A Case Report and Review of the Literature
Authors: Tjerk J Lagrand, Vincent A J Bruijnes, A M Madeleine Van der Stouwe, Eric A Deckers, Aryan Mazuri, Bram Jacobs
Journal: Neurotrauma Rep (2020)
Keywords: basilar artery, clivus fracture, entrapment, head trauma, locked-in syndrome

We report the case of a 58-year-old male with a rare vascular complication after traumatic head injury: entrapment of the basilar artery into a fracture of the clivus, ultimately leading to a locked-in syndrome due to brainstem infarction. Review of the literature revealed 19 earlier published cases of basilar artery entrapment within traumatic longitudinal clival fractures. In the majority of these patients there is an unfavorable neurological outcome.
Subdural effusions with hydrocephalus after severe head injury: successful treatment with ventriculoperitoneal shunt placement: report of 3 adult cases
Authors: N Tzerakis, G Orphanides, E Antoniou, P J Sioutos, S Lafazanos, A Seretis
Journal: Case Rep Med (2010)
MeSH terms: Case Reports

Background. Subdural collections of cerebrospinal fluid (CSF) with associated hydrocephalus have been described by several different and sometimes inaccurate terms. It has been proposed that a subdural effusion with hydrocephalus (SDEH) can be treated effectively with a ventriculoperitoneal shunt (V-P shunt). In this study, we present our experience treating patients with SDEH without directly treating the subdural collection. Methods. We treated three patients with subdural effusions and hydrocephalus as a result of a head injury. All the patients were treated with a V-P shunt despite the fact that there was an extra-axial CSF collection with midline shift. Results. In all of the patients, the subdural effusions subsided and the ventricular dilatation improved in the postoperative period. The final clinical outcome remains difficult to predict and depends not only on the successful CSF diversion but also on the primary and secondary brain insult. Conclusion. Subdural effusions with hydrocephalus can be safely and effectively treated with V-P shunting, without directly treating the subdural effusion which subsides along with the treatment of hydrocephalus. However, it is extremely important to make an accurate diagnosis of an SDEH and differentiate this condition from other subdural collections which require different management.
TAFRO Syndrome in Caucasians: A Case Report and Review of the Literature
Authors: Céline Louis, Sandrine Vijgen, Kaveh Samii, Yves Chalandon, Louis Terriou, David Launay, David C Fajgenbaum, Jörg D Seebach, Yannick D Muller
Journal: Front Med (Lausanne) (2017)
Keywords: castleman–kojima disease, caucasian, tafro, multicentric castleman’s disease, review of literature
MeSH terms: Case Reports

Background:
TAFRO syndrome has been reported in Japan among human herpesvirus 8 (HHV-8)-negative/idiopathic multicentric Castleman's disease (iMCD) patients. To date, the majority of iMCD patients with TAFRO syndrome originate from Japan.
Case presentation:
Herein, we report a 67-year-old HIV/HHV-8-negative Caucasian iMCD patient diagnosed with TAFRO. He presented with marked systemic inflammation, bicytopenia, terminal renal insufficiency, diffuse lymphadenopathies, and anasarca. Lymph node and bone marrow biopsies revealed atrophic germinal centers variably hyalinized and megakaryocytic hyperplasia with mild myelofibrosis. Several other biopsies performed in kidneys, liver, gastrointestinal tract, prostate, and lungs revealed unspecific chronic inflammation. The patient had a complete response to corticosteroids, tocilizumab, and rituximab. He relapsed twice following discontinuation of rituximab. When reviewing the literature, we found seven other Caucasian cases with TAFRO syndrome. There were no significant differences with those described by the Japanese cohort except for the higher frequency of kidney failure and auto-antibodies in Western patients.
Conclusion:
This case illustrates that patients with TAFRO syndrome can develop non-specific inflammation in several tissue sites. Furthermore, this case and our review of the literature demonstrate that TAFRO syndrome can affect Caucasian and Japanese patients highlighting the importance of evaluating for this syndrome independently of ethnic background.
An adult patient with Nijmegen Breakage Syndrome and Hodgkin's Lymphoma
Authors: Katharina Engel, Martina Rudelius, Felix G Meinel, Christian Peschel, Ulrich Keller
Journal: BMC Hematol (2014)
MeSH terms: Case Reports

Background:
Nijmegen Breakage Syndrome (NBS) is a rare autosomal recessive DNA repair disorder characterized by immune deficiency, microcephaly, mental retardation and a disposition for the development of hematological malignancies. So far, mostly pediatric patients have been described, since the underlying condition is often fatal before adulthood. Many patients diagnosed with Hodgkin lymphoma (HL) due to this DNA repair defect receive reduced treatment followed by early progression and fatal outcome.
Case presentation:
We describe here a 26-year old male caucasian patient with NBS who presented with multi organ failure due to HL. Immediate intensive chemotherapy lead to complete remission and reversed organ failure.
Conclusion:
We show that application of standard chemotherapy can lead to long-term disease free survival in patients with a DNA repair disorder. Furthermore, we describe here, to the best of our knowledge, the first adult patient with NBS and HL.
Drug Induced Liver Injury Attributed to a Curcumin Supplement
Authors: Zaid Imam, Majd Khasawneh, Diana Jomaa, Hira Iftikhar, Ziad Sayedahmad
Journal: Case Rep Gastrointest Med (2019)
MeSH terms: Case Reports

More severe reactions, higher acute liver failure rates, and higher recurrence rates on re-challenge occur with supplement-related Drug Induced Liver Injury (DILI) (Medina-Caliz et al., 2018). We report a case of curcumin-induced hepatocellular DILI in a 78-year old female admitted with jaundice, with a one-month latency. Extensive evaluation for alternative etiologies of hepatotoxicity was unremarkable. The Roussel Uclaf Causality Assessment Method (RUCAM) score of 6 for the supplement indicated a probable association (score >8: highly probable association). Peak levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were >20 times upper limit of normal. A 48% decrease in AST and ALT levels was observed 7 days after discontinuation of the supplement, and resolution of transaminitis was observed in 42 days. No re-challenge was performed. In conclusion, this case emphasizes the importance of recognizing curcumin supplements as DILI triggers. Furthermore, it reiterates the need for careful evaluation of herbal and dietary supplements (HDS) consumed by patients to identify potential DILI culprits, and to ultimately prevent DILI reactions with significant morbidity and mortality.