OpenMed/multicare-articles huggingface dataset:
Sensory disturbance along the inferior alveolar nerve as a first clinical sign of multiple florid cemento-osseous dysplasia of the mandible-A case report
Authors: Pascal Grün, Patrick Bandura, Andrew Grün, Walter Sutter, Oliver Meller, Dritan Turhani
Journal: Int J Surg Case Rep (2018)
Keywords: case report, cemento-osseous dysplasia, florid cemento-osseous dysplasia, osteomyelitis of the jawbone, sensory disturbance, tumour excision

Introduction:
Florid cemento-osseous dysplasia (FCOD) is a rare, benign, slow growing, multifocal fibro-osseous tumour originating from the periodontal ligament. The lesion is characterised by regular bone-structure replacement with fibrous tissue and dysplastic bone. The initial characteristics of FCOD, depending on localisation, resemble those of periapical lesions of inflammatory origin, potentially leading to misdiagnosis. In the absence of infection signs, the treatment of choice is conservative therapy with antibiotics and regular follow-up examinations.
Presentation of case:
We report the case of a 39-year-old Caucasian woman with sensory disturbance along the inferior alveolar nerve for >2 weeks. The involved teeth were vital and the digital orthopantomogram indicated multiple bilateral periapical brightening. Biopsy was indicated to exclude malignancy and to confirm the FCOD diagnosis with predominantly reactive calcification and cell-rich connective-tissue reaction. The sensory disturbances disappeared after the biopsy. Further conservative therapy included regular radiological examinations every 2 years to prevent surgical intervention due to infection risk.
Discussion:
Sensory disturbances around the nervus alveolaris inferior are well-known complications of dental and maxillofacial operations and of malignant tumours. Sensitivity disorder as a first symptom of fibro-osseous dysplasia has not been previously described. Although uncommon in its clinical behaviour, FCOD was finally diagnosed after thorough clinical, radiological, and histological examinations.
Conclusion:
Paraesthesia combined with FCOD has not been previously described. Correct diagnosis is essential for proper treatment and to avoid further complications even when the clinical symptoms appear unrelated.
Splenic Trauma during Colonoscopy: The Role of Intra-Abdominal Adhesions
Authors: Chukwunonso Chime, Charbel Ishak, Kishore Kumar, Venkata Kella, Sridhar Chilimuri
Journal: Case Rep Gastrointest Med (2018)
MeSH terms: Case Reports

Splenic rupture following colonoscopy is rare, first reported in 1974, with incidence of 1-21/100,000. It is critical to anticipate splenic trauma during colonoscopy as one of the causes of abdominal pain after colonoscopy especially when located in the left upper quadrant or left shoulder. Postoperative adhesions is a predisposing factor for splenic injury, and management is either operative or nonoperative, based on hemodynamic stability and/or extravasation which can be seen on contrast-enhanced CT scan of the abdomen. We present a case of a splenic rupture after colonoscopy in a patient with splenocolic adhesions, requiring splenectomy as definite treatment.
Short and long term outcome of bilateral pallidal stimulation in chorea-acanthocytosis
Authors: Marie Miquel, Umberto Spampinato, Chrystelle Latxague, Iciar Aviles-Olmos, Benedikt Bader, Kelly Bertram, Kailash Bhatia, Pierre Burbaud, Lothar Burghaus, Jin Whan Cho, Emmanuel Cuny, Adrian Danek, Thomas Foltynie, Pedro J Garcia Ruiz, Santiago Giménez-Roldán, Dominique Guehl, Jorge Guridi, Marwan Hariz, Paul Jarman, Zinovia Maria Kefalopoulou, Patricia Limousin, Nir Lipsman, Andres M Lozano, Elena Moro, Dhita Ngy, Maria Cruz Rodriguez-Oroz, Huifang Shang, Hyeeun Shin, Ruth H Walker, Fusako Yokochi, Ludvic Zrinzo, François Tison
Journal: PLoS One (2013)
MeSH terms: Deep Brain Stimulation / methods, Globus Pallidus / physiopathology, Neuroacanthocytosis / physiopathology, Neuroacanthocytosis / therapy, Multicenter Study, Research Support, Non-U.S. Gov't, Adult, Brain Abscess / etiology, Cross-Sectional Studies, Deep Brain Stimulation / adverse effects, Deep Brain Stimulation / instrumentation, Electrodes, Implanted, Female, Globus Pallidus / surgery, Humans, Linear Models, Male, Middle Aged, Neuroacanthocytosis / surgery, Prosthesis-Related Infections / etiology, Retrospective Studies, Time Factors, Treatment Outcome, Young Adult

Background:
Chorea-acanthocytosis (ChAc) is a neuroacanthocytosis syndrome presenting with severe movement disorders poorly responsive to drug therapy. Case reports suggest that bilateral deep brain stimulation (DBS) of the ventro-postero-lateral internal globus pallidus (GPi) may benefit these patients. To explore this issue, the present multicentre (n=12) retrospective study collected the short and long term outcome of 15 patients who underwent DBS.
Methods:
Data were collected in a standardized way 2-6 months preoperatively, 1-5 months (early) and 6 months or more (late) after surgery at the last follow-up visit (mean follow-up: 29.5 months).
Results:
Motor severity, assessed by the Unified Huntington's Disease Rating Scale-Motor Score, UHDRS-MS), was significantly reduced at both early and late post-surgery time points (mean improvement 54.3% and 44.1%, respectively). Functional capacity (UHDRS-Functional Capacity Score) was also significantly improved at both post-surgery time points (mean 75.5% and 73.3%, respectively), whereas incapacity (UHDRS-Independence Score) improvement reached significance at early post-surgery only (mean 37.3%). Long term significant improvement of motor symptom severity (≥ 20 % from baseline) was observed in 61.5 % of the patients. Chorea and dystonia improved, whereas effects on dysarthria and swallowing were variable. Parkinsonism did not improve. Linear regression analysis showed that preoperative motor severity predicted motor improvement at both post-surgery time points. The most serious adverse event was device infection and cerebral abscess, and one patient died suddenly of unclear cause, 4 years after surgery.
Conclusion:
This study shows that bilateral DBS of the GPi effectively reduces the severity of drug-resistant hyperkinetic movement disorders such as present in ChAc.
Case Report: A Domestic Sponge Brush Used to Clean a Milk Feeding Bottle: The Source of Neonatal Meningitis Caused by Pseudomonas aeruginosa
Authors: Shinsuke Mizuno, Sayaka Matsuzaki, Koji Yokoyama, Keigo Hamahata, Akira Yoshida
Journal: Front Pediatr (2021)
Keywords: pseudomonas aeruginosa, environment, infection prevention, neonatal meningitis, sponge brush
MeSH terms: Case Reports

Pseudomonas aeruginosa is a relatively rare cause of neonatal meningitis, and most patients have serious underlying diseases, prematurity, immunodeficiency, or anatomical abnormalities. We report the case of a 7-day-old girl with meningitis caused by P. aeruginosa. She was born full-term and had no immunodeficiency or anatomical abnormalities as far as our investigation ascertained. Through the use of anti-Pseudomonas antibiotics, she recovered without any complications other than a slight hearing disability revealed by audiology testing. P. aeruginosa was also isolated from a domestic sponge brush used to clean her milk bottle. Physicians should consider P. aeruginosa as a possible pathogen of neonatal meningitis even in full-term infants with no immunodeficiency or anatomical abnormalities. Physicians should give advice concerning appropriate hygiene practices to be applied to the neonate's environment.
Full-Mouth Screw-Retained Implant-Supported Rehabilitation with Multiunit Abutments Using Virtual Guided Surgery and Digital Prosthetics Protocol
Authors: Igor Ashurko, Artem Trofimov, Svetlana Tarasenko, Sabina Mekhtieva
Journal: Case Rep Dent (2020)
MeSH terms: Case Reports

Total rehabilitation is one of the most sophisticated kinds of dental implant-supported prosthetics. The usage of multiunit abutment system allows the clinician an accurate and passive fitting of screw-retained full-arch construction. In addition, it retains a condition of soft and bone tissues around prosthetic construction. The aim of this case is to demonstrate a modern approach in planning and realisation of full-mouth screw-retained dental implant prosthetics. A 59-year-old patient had an extraction of all failed teeth on upper and lower jaws with immediate 16 implant placement (8 implants on maxilla and 8 implants on mandible) using surgical template. Multiunit abutments were installed intraoperatively. Temporary constructions were fixed immediately after surgery. After 3 months of dental impressions, plaster models and their scan were prepared to make final screw-retained zirconium dioxide constructions. Reevaluation of functional and aesthetic result of the treatment was made after 12 months.
Cerebral Salt-Wasting Syndrome Caused by Minor Head Injury
Authors: Toshiki Fukuoka, Yuko Tsurumi, Arihito Tsurumi
Journal: Case Rep Emerg Med (2017)
MeSH terms: Case Reports

A 34-year-old woman was admitted to hospital after sustaining a head injury in a motor vehicle accident (day 1). No signs of neurological deficit, skull fracture, brain contusion, or intracranial bleeding were evident. She was discharged without symptoms on day 4. However, headache and nausea worsened on day 8, at which time serum sodium level was noted to be 121 mEq/L. Treatment with sodium chloride was initiated, but serum sodium decreased to 116 mEq/L on day 9. Body weight decreased in proportion to the decrease in serum sodium. Cerebral salt-wasting syndrome was diagnosed. This case represents the first illustration of severe hyponatremia related to cerebral salt-wasting syndrome caused by a minor head injury.
Complex Case of Open Fracture-Dislocation of the Elbow
Authors: Tommy Primeau, Philippe Beauchamp-Chalifour, Stéphane Pelet
Journal: Case Rep Orthop (2019)
MeSH terms: Case Reports

Complex elbow instability is difficult to surgically address. Careful consideration of the fractures and soft tissue injuries is required. We present the case of a patient who sustained an open fracture-dislocation of the elbow with significant loss of the external humeral condyle and partial loss of the olecranon. He was surgically treated with an iliac crest tricortical autograft fixed with a buttress plate and a lag screw. His lateral ulnar collateral ligament was reconstructed with tendinous autograft collected from his third and fourth extensor digitorum longus tendons. While the procedure complicated with a Nocardia infection and wound breakdown, the patient almost had full range of motion without instability at 11 months of follow-up.
Bilateral spontaneous simultaneous femoral neck occult fracture in a middle-aged man due to osteoporosis and vitamin D deficiency osteomalacia: A case report and literature review
Authors: Kiyokazu Fukui, Ayumi Kaneuji, Hiroaki Hirata, Jun-Ichi Tsujioka, Akihiro Shioya, Sohsuke Yamada, Norio Kawahara
Journal: Int J Surg Case Rep (2019)
Keywords: femoral neck fracture, occult fracture, osteomalacia, osteoporosis

Introduction:
Bilateral stress fracture of the femoral neck is very rarely seen in healthy young patients who are neither athletes nor military recruits.
Presentation of case:
The present report describes a 51-year-old male patient, not an athlete and with no previous history of disease, who developed bilateral stress fracture of the femoral neck without displacement.
Discussion:
Simultaneous bilateral femoral neck fracture is a rare injury. In the present case, two factors predisposed to bilateral occult fracture of the femoral neck. The first was osteoporosis due to the patient's smoking and alcohol abuse. The second was vitamin D deficiency osteomalacia associated with inadequate sun exposure.
Conclusion:
All patients who present with spontaneous hip pain should be evaluated for osteoporosis and osteomalacia and assessed for underlying occult fracture if they report groin pain or difficulty in walking, even when findings from plain X-ray are normal, to improve prognosis in this rare and serious condition.
A case report of metastatic lung adenocarcinoma with long-term survival for over 11 years
Authors: Tatsu Matsuzaki, Eri Iwami, Kotaro Sasahara, Aoi Kuroda, Takahiro Nakajima, Takeshi Terashima
Journal: Medicine (Baltimore) (2019)
MeSH terms: Antineoplastic Agents / therapeutic use, Antineoplastic Combined Chemotherapy Protocols / therapeutic use, Carcinoma, Non-Small-Cell Lung / drug therapy, Lung Neoplasms / drug therapy, Case Reports, Acrylamides, Aged, Aniline Compounds, Carboplatin / therapeutic use, Docetaxel / therapeutic use, ErbB Receptors / genetics, Erlotinib Hydrochloride / therapeutic use, Humans, Male, Piperazines / therapeutic use, Protein Kinase Inhibitors / therapeutic use, Acrylamides, Aniline Compounds, Antineoplastic Agents, Piperazines, Protein Kinase Inhibitors, Docetaxel, osimertinib, Carboplatin, Erlotinib Hydrochloride, ErbB Receptors

Rationale:
This is the first known report in the English literature to describe a case of metastatic non-small cell lung cancer that has been controlled for >11 years.
Patient concerns:
A 71-year-old man visited our hospital because of dry cough.
Diagnosis:
Chest computed tomography revealed a tumor on the left lower lobe with pleural effusion, and thoracic puncture cytology indicated lung adenocarcinoma.
Interventions:
Four cycles of carboplatin and docetaxel chemotherapy reduced the size of the tumor; however, it increased in size after 8 months, and re-challenge chemotherapy (RC) with the same drugs was performed. Repeated RC controlled disease activity for 6 years. After the patient failed to respond to RC, erlotinib was administered for 3 years while repeating a treatment holiday to reduce side effects. The disease progressed, and epidermal growth factor receptor (EGFR) gene mutation analysis of cells from the pleural effusion detected the T790 M mutation. Therefore, osimertinib was administered, which has been effective for >1 year.
Outcomes:
The patient has survived for >11 years since the diagnosis of lung cancer.
Lessons:
Long-term survival may be implemented by actively repeating cytotoxic chemotherapy and EGFR-tyrosine kinase inhibitor administration.
Leigh's Disease: The Acute Clinical Course of a Two-Year-Old Child with Subacute Necrotizing Encephalomyelopathy
Authors: Bettina Zinka, Andreas Buettner, Matthias Graw
Journal: Case Rep Med (2010)
MeSH terms: Case Reports

We report the untypical clinical course of a previously healthy two-year-old girl, who died suddenly and unexpectedly after an episode of vomiting. At forensic autopsy no other pathological findings could be diagnosed than multiple reddish, sunken areas in brain stem, mesencephalon, and pons. Histologically they presented as areas of spongiosis of the neuropil with prominent endothelial hyperplasia and vascular proliferation whereas nerve cells were well preserved. On the basis of the characteristic neuropathological findings in combination with the age of the child, we had to take into consideration that the child might have died from subacute necrotizing encephalomyelopathy (Leigh's Disease) despite the untypical, fulminant clinical course.
Endoscopic submucosal excavation for gastric plexiform fibromyxoma: A case report and systematic review of literature
Authors: Ziqin Xia, Zhidai Zhou, Wei Guo, Hongling Wang, Fan Wang, Feng Zhou
Journal: Front Oncol (2023)
Keywords: case report, endoscopic submucosal excavation (ese), mesenchymal tumor, plexiform fibromyxoma (pf), systematic review
MeSH terms: Case Reports

Plexiform fibromyxoma (PF) is a rare mesenchymal tumor of which the pathogenesis and molecular changes are still unclear. Histologically, it is characterized by a cluster of bland spindle or ovoid cells growing in the mucoid or fibromyxoid stroma rich in small blood vessels. At present, surgical resection is the primary treatment for PF.
15q23 Gain in a Neonate with a Giant Omphalocele and Multiple Co-Occurring Anomalies
Authors: Hui-Fang Zhou, Christopher J O'Conor, Chiraag Gangahar, Louis P Dehner
Journal: Case Rep Pediatr (2018)
MeSH terms: Case Reports

Background:
Omphalocele is a rare congenital abdominal wall defect. It is frequently associated with genetic abnormality and other congenital anomalies, although isolated omphalocele cases do exist. Data have shown that omphalocele with co-occurring genetic abnormality has worse prognosis than isolated omphalocele. Chromosomal analysis by a conventional technique such as karyotyping can only detect aneuploidy and large segmental duplication or deletion. Newer techniques such as high-resolution microarray analysis allow for the study of alterations in chromosomal segments that are less than 5 Mb in length; this has led to identification of critical region and genes in the pathogenesis of omphalocele.
Case presentation:
The current study is the initial report of a newborn male with a 15q23 gain and a giant omphalocele. High-resolution chromosomal microarray analysis identified this gain of copy number spanned 676 kb, involving almost the entire NOX5 gene (except for exon 1 of the longer transcript), the entirety of the EWSAT1, GLCE, PAQR5, KIF23, RPLP1, and DRAIC genes and exons 1-3 of the PCAT29 gene.
Conclusion:
To date, this is the first report of an associated 15q23 gain in a case with omphalocele. Interestingly, Giancarlo Ghiselli and Steven A Farber have reported that GLCE knockdown impairs abdominal wall closure in zebrafish. We also identified GLCE gene alteration in our case. This highlights the importance of GLCE in abdominal wall development. Further study of the function of GLCE and other genes might lead to a better understanding of the molecular mechanism of omphalocele.
Mixed Adenoneuroendocrine Carcinoma Is a Rare but Important Tumour Found in the Oesophagus
Authors: Mohammad Murad Kasim Kadhim, Marie Louise Jespersen, Hans Kristian Pilegaard, Marianne Nordsmark, Gerda Elisabeth Villadsen
Journal: Case Rep Gastrointest Med (2016)

Mixed adenoneuroendocrine carcinoma (MANEC) is a rare tumour of the gastrointestinal tract that consists of a dual adenocarcinomatous and neuroendocrine differentiation, each component representing at least 30% of the tumour. We report a case of a 68-year-old man who presented with two-month history of postprandial pain and vomiting. Gastric endoscopy revealed a polypoid mass in the lower part of the oesophagus. In contrast to the majority of these tumours, this biopsy was immunohistochemically positive for chromogranin A, and synaptophysin and Ki-67 index was 50% and the tumour was diagnosed as poorly differentiated neuroendocrine carcinoma of the oesophagus. The patient underwent surgery and lower oesophagus resection was performed. Based on the histopathology and immunohistochemistry of the tumour in the oesophagogastrectomy specimen, a mixed adenoneuroendocrine carcinoma (MANEC) was diagnosed. The objective of this case report is to advocate for the focus on the MANEC diagnosis as such patients need to be referred to a centre of excellence with expertise in NET tumours, to have the correct diagnostic work-up, treatment, and secondary diagnostic procedures performed at progression, as this will have paramount influence of the choice of treatment.
Ovariohysterectomy and Partial Vaginectomy for Treatment of Cervicovaginitis in a Dog
Authors: Christian A Folk, Cassie N Lux, Whitney DeGroot
Journal: Case Rep Vet Med (2019)
MeSH terms: Case Reports

A 1-year-old sexually intact female Labrador Retriever was evaluated for malodorous vaginal discharge, lethargy, and vomiting. A diagnosis of pyometra was suspected based on signalment, clinical signs, and abdominal ultrasonography. The dog underwent an exploratory celiotomy revealing a palpably enlarged cervix and edematous, fluid-filled vagina with an otherwise normal uterus. The ovaries, uterus, cervix, and cranial vagina were surgically resected. Histopathology revealed mild to moderate regionally extensive subacute neutrophilic cervicovaginitis due to an unknown underlying etiology. The dog did not exhibit any postoperative complications or recurrence of clinical signs in 6 months. This case represents an unusual disease condition, which presented in a manner typical for pyometra, yet required more extensive surgical resection.
The Clinical Impact of Methotrexate-Induced Stroke-Like Neurotoxicity in Paediatric Departments: An Italian Multi-Centre Case-Series
Authors: Andrea Santangelo, Emanuele Bartolini, Giulia Nuzzi, Thomas Foiadelli, Alexandre Michev, Tommaso Mina, Irene Trambusti, Valeria Fichera, Alice Bonuccelli, Gabriele Massimetti, Diego G Peroni, Emanuela De Marco, Luca Coccoli, Laura Luti, Sayla Bernasconi, Margherita Nardi, Maria Cristina Menconi, Gabriella Casazza, Dario Pruna, Rosamaria Mura, Chiara Marra, Daniele Zama, Pasquale Striano, Duccio M Cordelli, Roberta Battini, Alessandro Orsini
Journal: Front Neurol (2022)
Keywords: methotrexate, neurotoxicity, pseudo-stroke, stroke-like syndrome, subacute toxicity

Introduction:
Stroke-like syndrome (SLS) is a rare subacute neurological complication of intrathecal or high-dose (≥500 mg) Methotrexate (MTX) administration. Its clinical features, evoking acute cerebral ischaemia with fluctuating course symptoms and a possible spontaneous resolution, have elicited interest among the scientific community. However, many issues are still open on the underlying pathogenesis, clinical, and therapeutic management and long-term outcome.
Materials and methods:
We retrospectively analyzed clinical, radiological and laboratory records of all patients diagnosed with SLS between 2011 and 2021 at 4 National referral centers for Pediatric Onco-Hematology. Patients with a latency period that was longer than 3 weeks between the last MTX administration of MTX and SLS onset were excluded from the analysis, as were those with unclear etiologies. We assessed symptom severity using a dedicated arbitrary scoring system. Eleven patients were included in the study.
Results:
The underlying disease was acute lymphoblastic leukemia type B in 10/11 patients, while fibroblastic osteosarcoma was present in a single subject. The median age at diagnosis was 11 years (range 4-34), and 64% of the patients were women. Symptoms occurred after a mean of 9.45 days (± 0.75) since the last MTX administration and lasted between 1 and 96 h. Clinical features included hemiplegia and/or cranial nerves palsy, paraesthesia, movement or speech disorders, and seizure. All patients underwent neuroimaging studies (CT and/or MRI) and EEG. The scoring system revealed an average of 4.9 points (± 2.3), with a median of 5 points (maximum 20 points). We detected a linear correlation between the severity of the disease and age in male patients.
Conclusions:
SLS is a rare, well-characterized complication of MTX administration. Despite the small sample, we have been able to confirm some of the previous findings in literature. We also identified a linear correlation between age and severity of the disease, which could improve the future clinical management.
Case Report: Delayed presentation of penile epidermoid cyst following reconstruction for Peyronie's disease
Authors: Luriel I Smith-Harrison, Jacques Farhi, Raymond A Costabile, Ryan P Smith
Journal: F1000Res (2015)
Keywords: epidermoid cyst, penile mass, peyronie’s disease

Penile masses are a concerning finding for both patient and clinician upon initial presentation. There is a wide differential for penile masses from the benign (fibrous plaques, cysts, ulcerative lesions, benign penile pearly papules, etc.) to more concerning malignant lesions. A proper history and physical is the first step to determining the etiology of the mass and any future clinical interventions. In this paper, we review a case of a 73-year-old male who is found to have an enlarging mass during work-up for possible placement of inflatable penile prosthesis. Fortunately, the mass was determined to be a benign epidermoid cyst presenting thirty years after reconstruction for Peyronie's disease using dermal penile skin graft. With this unique presentation we review the scant literature on penile mass formation following Peyronie's repair.