OpenMed/multicare-articles huggingface dataset:
Case Report: Severe COVID-19 Pneumonia in a Patient With Relapsed/Refractory Hodgkin's Lymphoma
Authors: Ipek Yonal-Hindilerden, Fehmi Hindilerden, Metban Mastanzade, Tarik Onur Tiryaki, Sevim Tasan-Yenigun, Yusuf Bilen, Selcuk Aksoz, Arif Atahan Cagatay, Meliha Nalcaci
Journal: Front Oncol (2021)
Keywords: hodgkin’s lymphoma, allogeneic stem cell, brentuximab, coronavirus disease 2019, donor lymphocyte infusion
MeSH terms: Case Reports

First identified in China in December 2019, coronavirus disease 2019 (COVID-19) has rapidly evolved into a global pandemic. The presence of haematological malignancies are expected to increase the risk of adverse outcomes from this viral infection due to the immunosuppression brought about by the underlying cancer and the effects of therapy. We present a 55-year-old woman diagnosed with relapsed/refractory Hodgkin's lymphoma (HL) who had been heavily pretreated with multiagent chemotherapy, autologous hematopoietic stem cell transplantation (autoHCT), allogeneic hematopoietic stem cell transplantation (alloHCT) and was complicated with EBV associated posttransplant lymphoproliferative disease (PTLD) and chronic graft-versus-host-disease (GVHD). The patient was recently treated with brentuximab and donor lymphocyte infusion (DLI) for relapse after alloHCT. She suffered from severe COVID-19 pneumonia and eventually succumbed to acute respiratory distress syndrome (ARDS) and multiorgan failure. Of note, this is the first reported case of COVID-19 in a HL patient who was being treated with brentuximab for relapse after alloHCT.
Infantile-onset Pompe disease complicated by sickle cell anemia: Case report and management considerations
Authors: Rodrigo Tzovenos Starosta, Ying-Chen Claire Hou, Katelyn Leestma, Prapti Singh, Luke Viehl, Linda Manwaring, Jorge Luis Granadillo, Molly C Schroeder, Jamie N Colombo, Halana Whitehead, Patricia Irene Dickson, Monica L Hulbert, Hoanh Thi Nguyen
Journal: Front Pediatr (2022)
Keywords: alpha-glucosidase, enzyme replacement therapy, glycogen storage disorder type ii, immune tolerance induction, methotrexate, newborn screening, sickle cell anemia
MeSH terms: Case Reports

Infantile-onset Pompe disease (IOPD) is a rare, severe disorder of lysosomal storage of glycogen that leads to progressive cardiac and skeletal myopathy. IOPD is a fatal disease in childhood unless treated with enzyme replacement therapy (ERT) from an early age. Sickle cell anemia (SCA) is a relatively common hemoglobinopathy caused by a specific variant in the hemoglobin beta-chain. Here we report a case of a male newborn of African ancestry diagnosed and treated for IOPD and SCA. Molecular testing confirmed two GAA variants, NM_000152.5: c.842G>C, p.(Arg281Pro) and NM_000152.5: c.2560C>T, p.(Arg854*) in trans, and homozygosity for the HBB variant causative of SCA, consistent with his diagnosis. An acute neonatal presentation of hypotonia and cardiomyopathy required ERT with alglucosidase alfa infusions preceded by immune tolerance induction (ITI), as well as chronic red blood cell transfusions and penicillin V potassium prophylaxis for treatment of IOPD and SCA. Clinical course was further complicated by multiple respiratory infections. We review the current guidelines and interventions taken to optimize his care and the pitfalls of those guidelines when treating patients with concomitant conditions. To the best of our knowledge, no other case reports of the concomitance of these two disorders was found. This report emphasizes the importance of newborn screening, early intervention, and treatment considerations for this complex patient presentation of IOPD and SCA.
Case report: Incidentally discovered case of pheochromocytoma as a cause of long COVID-19 syndrome
Authors: Christian G Ziegler, Carina Riediger, Matthias Gruber, Carola Kunath, Martin Ullrich, Jens Pietzsch, Svenja Nölting, Timo Siepmann, Stefan R Bornstein, Hanna Remde, Georgiana Constantinescu
Journal: Front Endocrinol (Lausanne) (2022)
Keywords: complications, diagnostic delay, pheochromocytoma (pcc), plasma metanephrines, post covid-19, severe acute respiratory syndrome coronavirus 2
MeSH terms: Adrenal Gland Neoplasms / complications, Adrenal Gland Neoplasms / diagnosis, Adrenal Gland Neoplasms / surgery, COVID-19 / complications, Hypertension / complications, Pheochromocytoma / complications, Pheochromocytoma / diagnosis, Pheochromocytoma / surgery, Case Reports, Research Support, Non-U.S. Gov't, Adult, Blood Pressure Monitoring, Ambulatory, Dizziness / complications, Humans, Male, Metanephrine, Normetanephrine, Phenoxybenzamine, Post-Acute COVID-19 Syndrome, SARS-CoV-2, Normetanephrine, Phenoxybenzamine, Metanephrine

Pheochromocytomas (PCCs) are rare but potentially lethal tumors that arise from the adrenal medulla. The clinical suspicion and diagnosis of PCC can be challenging due to the non-specific nature of signs and symptoms. In many patients, infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could lead to long-term symptoms including fatigue, headaches, and cognitive dysfunction. Here, we present the case of a patient incidentally diagnosed with an adrenal mass that proved to be a PCC after imaging was performed due to persisting complaints after coronavirus disease 2019 (COVID-19) infection. A 37-year-old male patient was referred to our center because of a right-sided inhomogeneous adrenal mass, incidentally found during a computed tomographic scan of the thorax performed due to cough and dyspnea that persisted after COVID-19 infection. Other complaints that were present prior to COVID-19 infection included profuse sweating, dizziness, exhaustion with chronic fatigue, and concentration difficulties. The patient had no history of hypertension, his blood pressure was normal, and the 24-h ambulatory blood pressure monitoring confirmed normotension but with the absence of nocturnal dipping. Plasma normetanephrine was 5.7-fold above the upper limit (UL) of reference intervals (738 pg/ml, UL = 129 pg/ml), whereas plasma metanephrine and methoxytyramine were normal at 30 pg/ml (UL = 84 pg/ml) and <4 pg/ml (UL = 16 pg/ml), respectively. Preoperative preparation with phenoxybenzamine was initiated, and a 4-cm tumor was surgically resected. Profuse sweating as well as dizziness was resolved after adrenalectomy pointing toward PCC and not COVID-19-associated patient concerns. Altogether, this case illustrates the difficulties in recognizing the possibility of PCC due to the non-specific nature of signs and symptoms of the tumor, which in this case did not include hypertension and coincided with some of the symptoms of long COVID-19.
Case Report: Diffuse T wave inversions as initial electrocardiographic evidence in acute pulmonary embolism
Authors: Ogechukwu Egini, Alix Dufresne, Mazin Khalid, Chinedu Egini, Eric Jaffe
Journal: F1000Res (2018)
Keywords: pe, t-waves, inversion
MeSH terms: Chest Pain / physiopathology, Electrocardiography, Pulmonary Embolism / physiopathology, Case Reports, Acute Coronary Syndrome / blood, Acute Coronary Syndrome / physiopathology, Acute Disease, Aged, Arrhythmias, Cardiac / blood, Arrhythmias, Cardiac / physiopathology, Chest Pain / blood, Humans, Male, Pulmonary Embolism / blood, Troponin / blood, Troponin

Acute pulmonary embolism (PE) is a life-threatening condition and is typically diagnosed by a combination of symptoms, clinical signs and imaging. Electrocardiogram may be helpful in diagnosis, and the most widely described pattern of occurrence is the so-called S 1Q 3T 3 pattern. Here, we describe the case of an African-American male who presented with typical chest pain, diffuse T wave inversions with serial troponin elevation. There was initial concern for Wellen's syndrome but was finally diagnosed as acute PE. This case underscores the necessity of vigilance and a lower threshold for PE work up even in patients presenting as acute coronary syndrome.
Genetic detection and isolation of crimean-congo hemorrhagic fever virus, Kosovo, Yugoslavia
Authors: Anna Papa, Bojana Bozovi, Vassiliki Pavlidou, Evangelia Papadimitriou, Mijomir Pelemis, Aantonis Antoniadis
Journal: Emerg Infect Dis (2002)
MeSH terms: Hemorrhagic Fever Virus, Crimean-Congo / genetics, Hemorrhagic Fever Virus, Crimean-Congo / isolation & purification, Hemorrhagic Fever, Crimean / drug therapy, Hemorrhagic Fever, Crimean / virology, Case Reports, Adult, Antiviral Agents / therapeutic use, Female, Humans, Male, Phylogeny, Polymerase Chain Reaction, Precipitin Tests, RNA, Viral / genetics, Ribavirin / therapeutic use, Yugoslavia, Antiviral Agents, RNA, Viral, Ribavirin

Crimean-Congo hemorrhagic fever virus (C-CHFV) strains were isolated from a fatal case and the attending physician in Kosovo, Yugoslavia. Early, rapid diagnosis of the disease was achieved by reverse transcription-polymerase chain reaction. The physician was successfully treated with oral ribavirin. These cases yielded the first genetically studied C-CHFV human isolates in the Balkans.
Sternal Cleft associated with Patent Ductus Arteriosus, Atrial Septal Defect, and Subglottic Hemangioma: A rarity
Authors: Naser Sadeghian, Alireza Mirshemirani, Irandokht Sadeghian
Journal: APSP J Case Rep (2014)
Keywords: phaces syndrome, sternal cleft, subglottic hemangioma
MeSH terms: Case Reports

We present a 2-day-old female neonate with cleft of the upper sternum, patent ductus arteriosus (PDA), atrial septal defect (ASD), and subglottic hemangioma. Dimensional and Doppler echocardiography, abdominal ultrasonography, and imaging were performed. She underwent a surgical repair of sternal cleft in neonatal life. After 8 months, she developed respiratory distress, apnea due to subglottic hemangioma. She underwent urgent tracheostomy. Subglottic hemangioma was treated with the KTP532 laser.
Case Report: Cardiac Toxicity Associated With Immune Checkpoint Inhibitors
Authors: Ru Chen, Ling Peng, Zhihua Qiu, Yan Wang, Fen Wei, Min Zhou, Feng Zhu
Journal: Front Cardiovasc Med (2021)
Keywords: cancer, immune checkpoint inhibitors, immune-related adverse events, myocardial injury, myocarditis
MeSH terms: Case Reports

Immune checkpoint inhibitors (ICIs) have now emerged as a mainstay of treatment for various cancer. Along with the development of ICIs, immune-related adverse effects (irAEs) have been the subject of wide attention. The cardiac irAE, a rare but potentially fatal and fulminant effect, have been reported recently. This article retrospectively reviewed 10 cases from our hospital with cardiac irAEs, with severity ranging from asymptomatic troponin-I elevations to cardiac conduction abnormalities and even fulminant myocarditis. In our series, all the cases were solid tumors and lung cancer was the most frequent cancer type (4,40%). In total, three (30.0%) patients experienced more than one type of life-threatening complication. A systemic corticosteroid was given to nine patients (90.0%). The majority of cases (7, 70%) were performed at an initial dose of 1-2 mg/kg/day. Two (20.0%) patients were admitted to ICU, three (30.0%) patients were put on mechanical ventilation, two (20.0%) patients received the plasma exchange therapy, and one patient was implanted with a pacemaker. Two (20.0%) of the patients succumbed and died, with a median duration of 7.5 days (IQR5.0-10.0) from diagnosis of cardiac irAE to death. Based on these results, we recommend that clinicians be alert to cardiac irAEs, including performing cardiovascular examinations before ICI treatment to accurately diagnose suspected myocarditis, enabling immediate initiation of immunosuppressive therapy to improve prognosis.
Concurrent JAK2-Positive Myeloproliferative Disorder and Chronic Myelogenous Leukemia: A Novel Entity? A Case Report With Review of the Literature
Authors: Gilbert Bader, Bernard Dreiling
Journal: J Investig Med High Impact Case Rep (2019)
Keywords: bcr-abl translocation, jak2 mutation, chronic myelogenous leukemia, myeloproliferative disorder
MeSH terms: Bone Marrow Neoplasms / genetics, Fusion Proteins, bcr-abl / genetics, Janus Kinase 2 / genetics, Myeloproliferative Disorders / genetics, Case Reports, Review, Aged, Bone Marrow Neoplasms / blood, Humans, Leukemia, Myelogenous, Chronic, BCR-ABL Positive / blood, Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics, Male, Mutation, Myeloproliferative Disorders / blood, BCR-ABL1 fusion protein, human, Fusion Proteins, bcr-abl, JAK2 protein, human, Janus Kinase 2

JAK2 V617F mutation and BCR-ABL translocation have been considered to be mutually exclusive. However, many cases where both hits coexisted have been reported. We have personally managed a case too. We believe this hybrid entity is underdiagnosed. Thus, we decided to shed light on this "double hit" disease to improve its diagnosis and optimize its treatment. We reviewed the English literature in PubMed since JAK2 discovery. We found 33 cases reported so far. We summarized patient characteristics and analyzed possible interactions between JAK2 and BCR-ABL clones.
Intestinal perforation due to intestinal and colonic tuberculosis in a patient with HIV, a nearly lethal complication due to lack of adequate treatment and control in a limited resource country, a case report
Authors: William Aguayo, Patricio Gálvez, Pablo Acosta, Christian Rojas, Jose Torres, Johan Aguayo, Jonathan Ayala, Byron Camacho, Gabriel Molina
Journal: Int J Surg Case Rep (2019)
Keywords: hiv, hiv/tb coinfection, intestinal tuberculosis, tuberculosis

Background:
Coinfection involving Human Immunodeficiency Virus (HIV) and Mycobacterium tuberculosis are particularly problematic in resource-limited countries. When both pathogens are present, they accelerate the deterioration of immunological functions in the patient leading to premature death if left untreated. A close follow-up is essential in these high-risk subjects, as inadequate healthcare usually leads to further complications.
Case presentation:
We present a case of a 26-year-old woman with a past medical history of HIV infection. Nonetheless, she lacked adequate treatment and did not have sufficient medical supervision to control her disease. She presented to the emergency department with an acute abdomen and multiple bowel perforations that demanded intestinal resection. TB/HIV coinfection was detected and a final diagnosis of bowel perforation due to TB was established.
Conclusions:
A high index of suspicion is essential when approaching patients with HIV and acute abdominal pain. A thorough clinical history examination including past medical history, HIV/AIDS (Acquired immunodeficiency syndrome) progression status, and a careful clinical exam are paramount to an early diagnosis and timely medical treatment.
Case report: Successful treatment with daratumumab for pure red cell aplasia in a patient with mixed lymphoid chimerism after ABO-mismatched stem cell transplant for sickle cell disease
Authors: E Dovern, B J Biemond, E Nur
Journal: Front Immunol (2023)
Keywords: daratumumab (dara), hematopoietic (stem) cell transplantation (hcst), mixed chimerism, pure red cell aplasia (prca), sickle cell disease
MeSH terms: Anemia, Sickle Cell / complications, Anemia, Sickle Cell / therapy, Hematopoietic Stem Cell Transplantation / adverse effects, Red-Cell Aplasia, Pure / drug therapy, Red-Cell Aplasia, Pure / etiology, Case Reports, Adult, Antibodies, Monoclonal / therapeutic use, Chimerism, Hemagglutinins, Humans, daratumumab, Hemagglutinins, Antibodies, Monoclonal

Pure red cell aplasia (PRCA) is a serious complication after ABO-mismatched allogeneic hematopoietic stem cell transplantation (HSCT). Following HSCT, persistent anti-donor isohemagglutinins against donor ABO antigens are considered the immunological cause of PRCA. Patients with post-transplant PRCA are at risk for graft rejection and prolonged red blood cell transfusion dependency. No standard treatment exists. Recently however, the anti-CD38 monoclonal antibody daratumumab has been reported to be an effective treatment for post-transplant PRCA in patients with complete donor chimerism. Here, we describe the first case of PRCA in a patient with mixed lymphoid patient/donor chimerism that was successfully treated with daratumumab. This is also the first report of a transplant recipient with sickle cell disease who was treated with this relatively new approach. Fourteen months post-transplantation and twelve months after treatment with daratumumab, our patient has a normal complete blood count and the anti-donor isohemagglutinins remain undetectable despite mixed lymphoid chimerism. Mixed chimerism is a common manifestation in adult patients with sickle cell disease transplanted with non-myeloablative conditioning and a matched sibling donor. The application of non-myeloablative HSCT for patients with sickle cell disease is steadily increasing. Therefore, the incidence of PRCA in this setting might also increase. As the risk of graft rejection due to PRCA can be especially high in patients with mixed chimerism, clinicians should be aware that daratumumab can be an effective treatment in the setting of mixed chimerism.
Case Report: Persistent Moderate-to-Severe Creatine Kinase Enzyme Activity Elevation in a Subclinical Dog
Authors: Melissa Gunther, Jared A Jaffey, Jason Evans, Christopher Paige
Journal: Front Vet Sci (2021)
Keywords: ck, canine, hyperckemia, muscular dystrophy, myopathy
MeSH terms: Case Reports

A 4-year-old, male-castrated, mixed breed dog was presented for a routine wellness examination at which time a moderate increase in serum creatine kinase (CK) enzyme activity (hyperCKemia) (15,137 IU/L; reference interval 10-200 IU/L), and moderate increases in alanine transaminase and aspartate aminotransferase enzyme activities were first identified. There was no history of clinical abnormalities (e.g., lethargy, lameness, anorexia, dysphagia, weakness, gait abnormalities, or exercise intolerance) and the physical examination was unremarkable. The dog was screened for several relevant potential infectious diseases known to cause inflammatory myopathies and was treated empirically with clindamycin. The serum total CK enzyme activity remained increased, which prompted recommendations for an echocardiogram, electromyogram (EMG), and muscle biopsy acquisition. The echocardiogram and electrocardiographic monitoring were unremarkable. The EMG and muscle biopsies were declined by the owner. The dog was evaluated several times in the subsequent 5 years and remained subclinical with unremarkable physical examinations despite a persistent moderate-to-severe hyperCKemia. Differential diagnoses considered most likely in this dog were an occult/latent hereditary muscular dystrophic disorder or idiopathic hyperCKemia, a phenomenon not yet reported in the veterinary literature. This report describes for the first time, clinical and diagnostic features of a subclinical dog with persistent moderate-to-severe hyperCKemia.
First Case of Pleural Empyema Caused by Staphylococcus simulans: Review of the Literature
Authors: Amos Lal, Jamal Akhtar, Ashfaq Ullah, George M Abraham
Journal: Case Rep Infect Dis (2018)
MeSH terms: Case Reports

Staphylococcus simulans is a coagulase-negative organism, mainly an animal pathogen. Reports of human infection have been infrequent, mainly in patients with repeated animal contact. We report the first case of pleural empyema in an elderly woman. S. simulans tends to cause more severe infection because of a biofilm layer which helps in adherence and colonization of smooth surfaces, especially prosthetic devices, shunts, and catheters. The challenging problem even after CoNS isolation and identification is the assessment of their clinical relevance. Major factors that inhibit the penetration of antibiotics is the large-sized effusions/empyema, thickness of pleura, and the nature of antibiotic itself. Source control for septic patients remains the cornerstone of treatment along with optimal antimicrobial coverage. Staphylococcus simulans, a coagulase-negative staphylococcus, is emerging as an important cause of virulent infections with high mortality in humans. Given its propensity for multidrug resistance, including vancomycin, there is an imperative for early and accurate identification of the isolate. Despite aggressive treatment, the patient succumbed to her illness.
Laser vision correction on patients with sick optic nerve: a case report
Authors: Ming Chen
Journal: Case Rep Ophthalmol Med (2011)
MeSH terms: Case Reports

This 48-year-old white female with chronic optic disc edema is reported for the discussion of the management for the laser vision correction. Two procedures were considered, one was PRK (photorefractive keratectomy) and the other was LASIK (laser-assisted in-situ keratomileusis). A search strategy was developed to search evidence in the literature to support the decision in the selection of the better procedure for this patient. The evidences also were rigorously appraised for the validity. PRK was selected and performed on the patient with good outcome.
Acute spontaneous subdural hematoma as an inaugural presentation of systemic lupus erythematosus with acquired factor XIII deficiency: a case report
Authors: Tamba Marc Sandouno, Houda Bachir, Habiba Bennesser Alaoui, Siham Hamaz, Ahmed Amine Eloumri, Mohammed Berrimi, Khalid Serraj
Journal: Pan Afr Med J (2021)
Keywords: spontaneous, acute subdural hematoma, case report, factor xiii, systemic lupus erythematosus
MeSH terms: Factor XIII Deficiency / diagnosis, Hematoma, Subdural, Acute / diagnosis, Lupus Erythematosus, Systemic / diagnosis, Case Reports, Adult, Factor XIII Deficiency / complications, Female, Headache / etiology, Hematoma, Subdural, Acute / etiology, Hematoma, Subdural, Acute / therapy, Humans, Lupus Erythematosus, Systemic / complications, Lupus Erythematosus, Systemic / therapy, Magnetic Resonance Angiography, Tomography, X-Ray Computed

Acute spontaneous subdural hematoma is a rare clinical situation. Among its various etiologies, underlying coagulopathy is associated with a considerable risk of mortality. A 43-year-old female patient with no comorbidity and no personal or family history of bleeding disorders, consulted for acute and intense headache. The brain computed tomography (CT) scan showed a compressive left fronto-parietal acute subdural hematoma. The cerebral magnetic resonance angiography and routine hemostasis workup were normal. Factor XIII activity was low at 41% and the etiological investigation was consistent with the diagnosis of systemic lupus erythematosus. Surgical evacuation of the hematoma, factor XIII supplementation and systemic corticosteroid therapy with hydroxy chloroquine resulted in a favorable outcome. Acquired factor XIII deficiency should be systematically investigated for any acute spontaneous subdural hematoma with a normal hemostasis assessment in an adult with no personal or family history of hemorrhage.
Cardiac Magnetic Resonance for Diagnosis of Neuroendocrine Tumor Metastases to the Right and Left Ventricles with Carcinoid Heart Disease
Authors: Daniel Barnebee, Brian Morse, Jonathan R Strosberg, Marijan Pejic, Daniel Jeong
Journal: Case Rep Cardiol (2019)
MeSH terms: Case Reports

A 76-year-old male with a small bowel neuroendocrine tumor with hepatic metastases presented with new onset lower extremity swelling, bloating, and weight gain which ultimately lead to cardiac magnetic resonance (CMR) to evaluate for cardiac involvement of disease. CMR showed right and left ventricular myocardial metastases along with findings suggestive of carcinoid heart disease. The patient had severe tricuspid valve regurgitation necessitating surgical valve repair. The patient underwent bioprosthetic tricuspid valve replacement and debulking of the metastases with surgical pathology confirming neuroendocrine tumor metastases. Follow-up clinical evaluations at 3, 6, and 9 months postoperatively showed improvement in cardiac function and stable hepatic tumor burden. This case demonstrates the utility of CMR to diagnose myocardial metastases and carcinoid heart disease complicated by severe tricuspid regurgitation, which guided surgical management.