OpenMed/multicare-articles huggingface dataset:
An Unusual Adenomatoid Tumor of Fimbria with Pronounced Psammoma Bodies in a BRCA Positive Patient as a Pitfall for Carcinoma on Frozen Section
Authors: Christine M Lee, Michelle Moh, Peggy S Sullivan, Neda A Moatamed
Journal: Case Rep Pathol (2018)
MeSH terms: Case Reports

Background:
BRCA gene mutations significantly increase the risk of breast and ovarian cancers where the lifetime risk of the ovarian cancer is about 40%. Therefore, many women with such mutations undergo prophylactic bilateral mastectomy and salpingo-oophorectomy. About 5-6% of these individuals display occult carcinomas in tubo-ovarian locations of which over 85% are tubal in origin. The objective of this case study was to emphasize emergence of benign lesions mimicking cancer under these circumstances.
Case report:
We present a case with positive BRCA1 mutation who underwent the prophylactic procedure where a small mass was identified in her fallopian tube. Our initial encounter with this tumor was during intraoperative consultation. The tumor was associated with extensive psammoma bodies arranged in closely packed small tubules, mimicking serous carcinoma. Frozen section limitations including artifact, time constraint, and lack of ancillary studies as well as the clinical history further complicated our diagnostic assessment, which was deferred. A diagnosis of adenomatoid tumor was rendered on permanent sections.
Conclusion:
It is important to be familiar with this morphologic presentation of adenomatoid tumor as it is a pitfall for carcinoma, particularly on frozen section, and inaccurate diagnosis could lead to further unnecessary extensive procedures.
Assessment of Occlusal Function in a Patient with an Angle Class I Spaced Dental Arch with Periodontal Disease Using a Brux Checker
Authors: Ayako Taira, Shiho Odawara, Shuntaro Sugihara, Kenichi Sasaguri
Journal: Case Rep Dent (2018)
MeSH terms: Case Reports

Comprehensive and appropriate occlusion reconstruction therapy is necessary for orthodontic treatment of adult patients with malocclusion with periodontal disease associated with occlusal trauma. We report the case of a patient with extensive moderate chronic periodontitis associated with occlusal trauma. The patient was diagnosed with extensive moderate chronic periodontitis associated with occlusal trauma and underwent thorough treatment for periodontal disease, oral management, and 20 months of orthodontic therapy. Moreover, reconstructed occlusion was performed to evaluate occlusal trauma for visualization using Brux Checker (BC) analysis before and after active orthodontic treatment. The patient acquired stable anterior guidance and a functional occlusal relationship. BC findings revealed weakening of the functional contact between the lateral occlusal force of the dentition and the front teeth and alveolar bone regeneration. The laminar dura became clearer, and the periodontal tissue improved. Our results suggest that assessment of occlusion function using BC analysis and periodontal examination was effective in enabling occlusal treatment goal clarification through orthodontic treatment in case of periodontal disease associated with occlusal trauma.
Case Report: Reversal of Hyaluronic Acid Rectal Wall Infiltration with Hyaluronidase
Authors: Anne Hong, Joseph Ischia, Michael Chao
Journal: Front Oncol (2022)
Keywords: hyaluronic acid, hyaluronidase, prostate cancer, radiation therapy, rectal spacer
MeSH terms: Case Reports

Peri-rectal spacers provide protection to the rectum for patients receiving radiation therapy treating prostate cancers. Commonly used hydrogel spacers hold the disadvantage that they cannot be readily reversed should inadvertent injection outside of the target area occurs, potentially leading to ischemia of the rectal mucosa leading to severe pain and ulceration, which can then lead to superinfection and pelvic abscess formation, and subsequently recto-prostatic fistulas. This could require major surgical intervention. New hyaluronic acid spacers are readily reversible with hyaluronidase and provide a valuable means to correct any misinjected spacer. We present a patient with prostate cancer who was planned for radiation therapy and required a rectal spacer. The hyaluronic acid rectal spacer was injected in part into the rectal wall. The patient was asymptomatic, and a sigmoidoscopy confirms healthy bowel mucosa only. The misinjected hyaluronic acid was successfully treated with targeted injection of hyaluronidase into only the rectal wall portion. Serial follow-up imaging demonstrated rapid dissolution of the misinjected hyaluronic acid with the well-positioned hyaluronic acid remaining. The patient did not experience any side effects of the hyaluronidase.
Sellar Glomus Tumor Misdiagnosed as Pituitary Adenoma: A Case Report and Review of the Literature
Authors: Yijun Cheng, Hao Tang, Zhe Bao Wu
Journal: Front Endocrinol (Lausanne) (2022)
Keywords: endoscopic transsphenoidal approach, glomus tumor, hypopituitarism, pituitary adenoma, sellar
MeSH terms: Adenoma / diagnosis, Adenoma / pathology, Glomus Tumor / diagnosis, Glomus Tumor / surgery, Hypopituitarism / diagnosis, Hypopituitarism / etiology, Pituitary Neoplasms / diagnosis, Pituitary Neoplasms / pathology, Case Reports, Review, Research Support, Non-U.S. Gov't, Aged, Diagnostic Errors, Humans, Male

Glomus tumor is a rare mesenchymal tumor with an organ-like structure. Sellar glomus tumors are extremely rare with only six reported cases in the literature. Because of the lack of special clinical manifestations and imaging features, the disorder may be easily misdiagnosed as other sellar tumors, especially pituitary adenomas. Here, the present study showed a case of a 69-year-old male with hypopituitarism who was preliminarily misdiagnosed as non-functional pituitary adenoma.
Solitary giant neurofibroma of the neck subjected to photodynamic therapy: case study
Authors: Zaid Hamdoon, Waseem Jerjes, Raed Al-Delayme, Colin Hopper
Journal: Head Neck Oncol (2012)
MeSH terms: Head and Neck Neoplasms / drug therapy, Neurofibroma / drug therapy, Photochemotherapy / methods, Case Reports, Aged, Female, Humans, Mesoporphyrins / administration & dosage, Photosensitizing Agents / administration & dosage, Treatment Outcome, Mesoporphyrins, Photosensitizing Agents, temoporfin

Photodynamic therapy (PDT) - the fourth modality - has been successfully used in the management of early and advanced pathologies of the head and neck. We studied the effect of this modality on a giant solitary neurofibroma of the neck. A 70-year-old Caucasian female presented with left neck pain and disfigurement associated with slight shortness of breath and dysphagia. Examination revealed a large mass in the neck with no neurovascular compromise. Magnetic resonance imaging (MRI) reported a heterogeneously enhancing mass extending from the left angle of the mandible to the base of the neck. A core biopsy was performed and histopathological examination revealed a disorganised array of peripheral nerve fascicles. The patient elected to receive photodynamic therapy as the primary intervention. The multi-disciplinary meeting approved the treatment plan. The photosensitizing agent was mTHPC (0.15 mg/kg), which was systemically administered 96-hours prior to ultrasound (US)-guided light delivery to the mass, which was undertaken under general anaesthesia. Recovery was uneventful. Post-PDT follow-up showed that the patient's pain, dysphagia and shortness of breath issues had improved. The disfigurement of the neck caused by the mass was no longer a problem. Three months post-PDT, MRI revealed a significant reduction in the neurofibroma size. PDT was proven as a successful primary intervention for this pathology. However, higher evidence-based studies are required before this therapy can be proposed as a replacement to any of the other conventional therapies.
A case study of interdisciplinary thematic learning curriculum to cultivate "4C skills"
Authors: Peiqi Ye, Xionghu Xu
Journal: Front Psychol (2023)
Keywords: collaboration, communication, creativity, critical thinking, interdisciplinary thematic learning

Critical thinking, communication, collaboration, and creativity are four fundamental skills for students in the 21st century, indicating the way for nurturing talents required for future social development. Interdisciplinary thematic learning has become an important educational carrier for "4C Skills" training, with its connotation coinciding with the training requirements of "4C Skills." Few academics, however, have looked into interdisciplinary thematic learning activities based on real-world problems. In this study, using a middle school in Xiamen, Fujian Province as an example, 32 s-year students in middle school were given several problem-solving tasks relevant to "visual disaster weather." Based on test coding and questionnaire evaluation, class notes, course videos, student solutions, and interview texts, we examined the development of students' 4C skills through real-world problem-based interdisciplinary thematic learning activities. This study discovered that an interdisciplinary thematic learning environment centered on real-world challenges fosters students' creative thinking in open practice while also encouraging group communication and collaboration. Students also gain critical thinking skills through questioning and critique.
Autoimmune Hepatitis (AIH) in Acquired Immune Deficiency Syndrome (AIDS): A Case Report and Review of Literature
Authors: Jordan Roussel, Sudha Pandit, Paul Jordan, Moheb Boktor, Kurt Knowles, Nester Dela Cruz, Hrishikesh Samant
Journal: Case Reports Hepatol (2019)
MeSH terms: Case Reports

The common causes of abnormal liver chemistries in human immunodeficiency virus (HIV) infected patients are multifactorial. Diagnosis of autoimmune hepatitis (AIH) in HIV infected patients is intriguing but data is scarce. Unmasking of AIH during immune reconstitution in HIV patients after starting antiretroviral therapy is reported but not with advanced acquired immunodeficiency syndrome (AIDS). Here we present a fascinating case of 32-year-old African-American man with advanced AIDS who presented with elevated transaminases. He was diagnosed with AIH before starting antiretroviral therapy and successfully treated with prednisolone and azathioprine with antiretroviral therapy despite very low CD4 count.
Case report of a successful multidisciplinary approach to a giant scrotal malformation
Authors: A Ascoli Marchetti, G Citoni, R Gandini, A Ippoliti
Journal: Int J Surg Case Rep (2020)
Keywords: embolization, giant arteriovenous malformation, multidisciplinary, previous surgery, selective angiography
MeSH terms: Case Reports

Introduction:
Congenital pelvic malformations are rare and represent a difficult therapeutic challenge. Scrotal arteriovenous malformations are quite unusual, with only a few such cases reported in the literature. Only one case of scrotal malformation? due to an arteriovenous fistula resulting in azoospermia has been described.
Presentation of case:
The two-phase strategy adopted in that case permitted complete treatment of a large-sized malformation that was served by 4 main blood confluences.
Discussion:
Angio-CT performed using reconstructions with MIP and SSD algorithms provided more detailed data about the extension of the afferents and efferents of the arteriovenous malformation, thus enabling us to plan the endovascular treatment of the lesion.
Conclusion:
A multidisciplinary approach is mandatory to achieve good results in these cases.
Acute Myopericarditis after the Second Dose of mRNA COVID-19 Vaccine Mimicking Acute Coronary Syndrome
Authors: Chris Pantsios, Zacharias-Alexandros Anyfantakis, Andrew Xanthopoulos, Ioannis Leventis, Spyridon Skoularigkis, Apostolos Dimos, Angeliki Bourazana, Michail Papamichalis, Grigorios Giamouzis, Filippos Triposkiadis, John Skoularigis
Journal: Case Rep Cardiol (2022)
MeSH terms: Case Reports

Myocarditis is a rare adverse event of vaccination. Recently, mRNA vaccines for COVID-19 have been reported to correlate with myocarditis, specifically in adolescents and young men. We report a rare case of a 50-year-old man who presented with symptoms of myocardial infarction 3 days after the second dose of vaccination for COVID-19. Cardiac magnetic resonance (CMR) imaging revealed acute myopericarditis. Clinicians should be aware of that rare side effect of mRNA vaccines for COVID-19 that can affect not only younger recipients but also middle-aged patients presenting with symptoms mimicking acute coronary syndrome.
An unusual presentation of LCAT deficiency as nephrotic syndrome with normal serum HDL-C level
Authors: Manish R Balwani, Vijaykumar A Ghodela, Vivek B Kute, Pankaj R Shah, Himanshu V Patel, Dinesh N Gera, Aruna Vanikar, Hargovind L Trivedi
Journal: J Nephropharmacol (2016)
Keywords: anemia, corneal deposit, lcat deficiency, nephrotic syndrome
MeSH terms: Case Reports

Clinical and biochemical manifestations of lecithin-cholesterol acyltransferase (LCAT) deficiency include an abnormal lipid profile (characterized by hypercholesterolemia with markedly decreased high-density lipoprotein cholesterol [HDL-C] and hypertriglyceridemia), corneal opacities, hematologic abnormalities (normochromic anemia of varying intensity), splenomegaly, variable early coronary artery disease and nephropathy (initially proteinuria followed by progressive deterioration of renal function). We presented a patient with nephrotic syndrome, which renal biopsy revealed classic features of LCAT deficiency. To our knowledge, the present case is the first reported case of LCAT deficiency presenting with symptoms related to nephrotic syndrome in a patient with no obvious family history without any corneal deposits and normal HDL-C levels.
Cytokine expression in CD3+ cells in an infant with food protein-induced enterocolitis syndrome (FPIES): case report
Authors: F Mori, S Barni, A Cianferoni, N Pucci, M de Martino, E Novembre
Journal: Clin Dev Immunol (2009)
MeSH terms: Enterocolitis / immunology, Food Hypersensitivity / immunology, Oryza / adverse effects, Th2 Cells / metabolism, Case Reports, Breast Feeding, CD3 Complex / biosynthesis, Cytokines / metabolism, Diarrhea, Enterocolitis / chemically induced, Enterocolitis / diagnosis, Enterocolitis / physiopathology, Food Hypersensitivity / diagnosis, Food Hypersensitivity / physiopathology, Humans, Immune Tolerance, Immunization, Infant, Male, Oryza / immunology, Th1 Cells / immunology, Th1 Cells / metabolism, Th1 Cells / pathology, Th2 Cells / immunology, Th2 Cells / pathology, Vomiting, CD3 Complex, Cytokines

Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy characterized by severe vomiting, diarrhea, and often failure to thrive in infants. Symptoms typically resolve after the triggering food-derived protein is removed from the diet and recur within few hours after the re-exposure to the causal protein. The diagnosis is based on clinical symptoms and a positive food challenge. In this study, we report a case of FPIES to rice in an 8-month-old boy. We performed a double-blind placebo-controlled food challenge (DBPCFC) to rice and we measured the intracellular T cell expression of interleukin-4 (IL-4); IL-10, and interferon gamma (IFN-gamma) pre-and post-challenge during an acute FPIES reaction and when tolerance to rice had been achieved. For the first time we describe an increase in T cell IL-4 and decrease in IFN-gamma expression after a positive challenge with rice (i.e. rice triggered a FPIES attack) and an increase in T cell IL-10 expression after rice challenge 6 months later after a negative challenge (i.e., the child had acquired tolerance to rice) in an 8 month old with documented FPIES to rice. A Th2 activation associated with high IL-4 levels may contribute to the pathophysiology of the disease. On the other hand, T cell-derived IL-10 may play a role in the acquisition of immunotolerance by regulating the Th1 and Th2 responses.
Juvenile psammomatoid ossifying fibroma with aneurysmal bone cyst in the posterior mandible
Authors: Sandhya Tamgadge, Tamgadge Avinash, Sudhir Bhalerao, Sonali Rajhans
Journal: Ecancermedicalscience (2014)
Keywords: aneurysmal bone cyst, fine needle aspiration cytology (fnac), mandible, psammoma bodies, psammomatoid juvenile ossifying fibroma
MeSH terms: Case Reports

Aneurysmal bone cysts (ABCs) are a rare benign lesion seen as locally destructive, rapidly expansile, and mostly affecting the long bones and vertebrae. The association of ABCs with juvenile psammomatoid ossifying fibroma (PsJOF) is predominantly seen in the extragnathic region, and it is extremely rare with only a few cases reported so far in the mandible. Here, we report one such case of a hybrid lesion in a seven-year-old boy, who presented with a solitary swelling of the left mandible showing partial obliteration of buccal vestibular sulcus, which shows juvenile psammomatoid ossifying fibroma as a pre-exsiting lesion, transforming into an ABC. Such hybrid lesions are usually misdiagnosed and have been sparsely reported in the dental literature.
Intraosseous hibernoma: case report and tumor characterization
Authors: A Jerman, Ž Snoj, B G Kuzmanov, A K Limpel Novak
Journal: BJR Case Rep (2015)
MeSH terms: Case Reports

Intraosseous hibernoma is a rare finding that has only recently come to light in the literature. We report a case of intraosseous hibernoma in the sacrum identified as an incidental finding in a 40 year-old female with chronic lower back pain. The tumor was characterized with all routine imaging modalities. In the review of the literature we correlate the imaging findings with previously reported cases. With increasing number of radiologic investigations it is expected to discover more intraosseous hibernomas and the radiologists should consider intraosseous hibernoma as differential diagnosis of the sclerotic bone lesion.
Atypical Presentation of PKDL due to Leishmania infantum in an HIV-Infected Patient with Relapsing Visceral Leishmaniasis
Authors: Benedetto Maurizio Celesia, Bruno Cacopardo, Daniela Massimino, Maria Gussio, Salvatore Tosto, Giuseppe Nunnari, Marilia Rita Pinzone
Journal: Case Rep Infect Dis (2014)

We describe the case of an Italian patient with HIV infection who developed an atypical rash resembling post-kala-azar dermal leishmaniasis (PKDL) when receiving liposomal Amphotericin B (L-AMB) for secondary prophylaxis of visceral leishmaniasis (VL). At the time of PKDL appearance, the patient was virologically suppressed but had failed to restore an adequate CD4+ T-cell count. Histology of skin lesions revealed the presence of a granulomatous infiltrate, with lymphocytes, plasma cells, and macrophages, most of which contained Leishmania amastigotes. Restriction fragment length polymorphism-polymerase chain reaction was positive for Leishmania infantum. Paradoxically, cutaneous lesions markedly improved when a new relapse of VL occurred. The patient received meglumine antimoniate, with a rapid clinical response and complete disappearance of cutaneous rash. Unfortunately, the patient had several relapses of VL over the following years, though the interval between them has become wider after restarting maintenance therapy with L-AMB 4 mg/kg/day once a month. Even if rare, PKDL due to Leishmania infantum may occur in Western countries and represents a diagnostic and therapeutic challenge for physicians. The therapeutic management of both PKDL and VL in HIV infection is challenging, because relapses are frequent and evidence is often limited to small case series and case reports.
Vaginal Delivery at Term in a Woman with a Spontaneous Heterotopic Pregnancy Treated with Laparoscopic Salpingectomy
Authors: Michail Diakosavvas, Nikolaos Blontzos, Georgios Daskalakis, Athanasios Protopapas, Nikolaos Kathopoulis, Panagiotis Antsaklis, Grigorios Derdelis, Kyveli Angelou, Zacharias Fasoulakis, Dimitrios Loutradis, Marianna Theodora
Journal: Case Rep Obstet Gynecol (2020)
MeSH terms: Case Reports

Background. The coexistence of an intrauterine pregnancy and an ectopic pregnancy (heterotopic pregnancy) is an extremely rare, yet major, complication during pregnancy. The early diagnosis of a heterotopic pregnancy is of great importance for fetal viability, maternal safety, and the progression of an uncomplicated intrauterine pregnancy. Case Presentation. We report a case of a naturally conceived heterotopic tubal pregnancy in a 37-year-old primigravida. The patient presented with continuous, dull, lower abdominal pain and a positive urine pregnancy test which was conducted a week prior to the start of the pain. The patient was hospitalized, and based on the clinical image and after strict monitoring, she was diagnosed with a heterotopic pregnancy. She was treated with laparoscopic salpingectomy after the rupture of the ectopic pregnancy while the desired intrauterine gestation continued without any complications. The pregnancy resulted in the birth of a healthy infant through vaginal delivery. Discussion. Strict monitoring with multiple sonographic evaluations should always be conducted in women with abnormal serum beta-hCG, adnexal abnormalities, or clinical symptoms, while heterotopic pregnancy should be in differential diagnosis and treatment should not be delayed since emerge management is important for the progression of the intrauterine pregnancy.
A Successful Whole Body Therapeutic Hypothermia for Hypoxic Ischemic Encephalopathy During an ECMO Run in a Newborn
Authors: Emel Okulu, Omer Erdeve, Bahar Bingoler Pekcici, Tanil Kendirli, Zeynep Eyileten, Begum Atasay, Saadet Arsan
Journal: Front Pediatr (2019)
Keywords: extracorporeal membrane oxygenation, hypoxic ischemic encephalopathy, newborn, outcome, therapeutic hypothermia
MeSH terms: Case Reports

Data regarding the safety of using therapeutic hypothermia (TH) with extracorporeal membrane oxygenation (ECMO) in neonates with both hypoxic ischemic encephalopathy (HIE), and respiratory failure are lacking. TH is not associated with an increased incidence of hemostatic complications, but hypothermia may impair coagulation. Herein, we report a case of a newborn who had meconium aspiration syndrome and HIE and underwent both TH and ECMO. He did not have any bleeding or circuit complications, and mortality as short-term outcome along with well-neurodevelopmental outcome.