OpenMed/multicare-articles huggingface dataset:
Measles outbreak in a poorly vaccinated region in Cameroon: a case series study, public health challenges and recommendations
Authors: Tsi Njim, Leopold Ndemnge Aminde, Fambombi Vitalis Feteh, Joel Mbigha Ngum, Chandini Aliyou Moustapha
Journal: Pan Afr Med J (2015)
Keywords: cameroon, measles, outbreaks
MeSH terms: Disease Outbreaks, Measles / epidemiology, Measles Vaccine / administration & dosage, Public Health, Case Reports, Bacterial Infections / complications, Bacterial Infections / epidemiology, Cameroon / epidemiology, Child, Child, Preschool, Diagnosis, Differential, Female, Health Policy, Humans, Infant, Male, Measles / diagnosis, Measles / prevention & control, Measles Vaccine

Measles is a highly contagious viral infection and still a leading cause of vaccine-preventable deaths in Africa; especially in unvaccinated populations. We reviewed the medical reports of the measles outbreak that occurred in Misaje, in the North west region of Cameroon from 11/03/2015 to 14/05/2015. Six measles cases were recorded during this period; three of them complicated by bacterial infections. Measles should be considered as a differential diagnosis for any febrile rash especially among poorly vaccinated populations. Primary preventive methods implemented by clinicians could help control outbreaks; especially with delays in public health intervention. Also, gaps in health policies in Cameroon should be addressed to scale up vaccination coverage in remote communities like Misaje to reduce the incidence of measles outbreaks.
Reconstruction of the Neopulmonary Root After Coronary Button Harvest for Arterial Switch Operation Using 2-ply Extracellular Matrix (Tyke): A Post-Implant Histology
Authors: Steve Bibevski, Mark Ruzmetov, Elena Ladich, Laura E Mendoza, Frank G Scholl
Journal: Front Cardiovasc Med (2020)
Keywords: cormatrix, ecm, arterial switch operation, extra cellular matrix, heart repair, histology, pulmonary artery
MeSH terms: Case Reports

In children with Transposition of the Great Arteries (TGA), the pulmonary artery, and aorta are connected to the heart abnormally resulting in blue blood (deoxygenated) recirculating to the body and red blood (oxygenated) recirculating to the lungs. The arterial switch operation (ASO) is the standard of care for transposition of the great arteries (TGA), and given the low risk of early mortality and satisfactory long-term outcomes, focus is now on managing longer term complications such as neo-aortic root dilatation, and pulmonary artery stenosis. Since May 2016, we have used 2-ply extracellular matrix (ECM; Tyke) for reconstruction of the coronary button defects using a pantaloon patch. We present histology of implanted 2-ply ECM (Tyke) from a patient who went back to surgery for development of subaortic stenosis ~12 months after ASO.
Pelvic Desmoid Tumor: A Rare Case with Difficult Diagnosis and Treatment
Authors: Mariana Ormonde, Despoina Argyropoulou, Cândida Lourenço, João Bastos, Ana Quintas
Journal: Case Rep Obstet Gynecol (2022)
MeSH terms: Case Reports

Desmoid tumors are rare benign neoplasms, with locally aggressive characteristics. Ongoing or previous pregnancy, antecedent trauma, and familial adenomatous polyposis are known risk factors. Still, the majority of cases are sporadic and its etiology is still unknown. These tumors may occur in any body site, but retroperitoneal and pelvic desmoid tumors are extremely rare. Nonspecific clinical and radiological findings lead to erroneous diagnosis in 50% of patients before surgery. We present a case of a young multiparous female with a deep infiltrative lesion adherent to the right pelvic sidewall leading to severe right hydroureteronephrosis and ipsilateral loss of renal function. Although deep endometriosis was suspected, malignancy features could not be excluded by imaging studies. The patient underwent an exploratory laparotomy for definite diagnosis and treatment, which led to right nephrectomy, hysterectomy, and right oophorectomy because of deep infiltration and difficult dissection. Definite histologic diagnosis revealed the presence of a pelvic desmoid tumor. Positive margins were encountered but, until this moment, no disease relapse occurred.
Granuloma Annulare in the Setting of Secukinumab
Authors: Matthew L Clark, Courtney A Tobin, Angela Sutton, Tricia Ann Missall
Journal: Case Rep Dermatol Med (2018)
MeSH terms: Case Reports

Granuloma annulare (GA) is a common benign inflammatory skin condition classically presenting as skin-colored to erythematous dermal papules and annular plaques. Histologically, GA displays a dermal granulomatous infiltrate with palisaded histiocytes surrounding focally altered collagen. The exactly etiology of GA remains unknown, but it has been associated with trauma, various infections, diabetes mellitus, malignancy, thyroid disease, dyslipidemia, and several medications. In 2017, a case of GA developing in a patient treated with the interleukin 17A antagonist secukinumab was reported. Here we report a second case of GA in association with secukinumab use.
Isolated langerhans cell histiocytosis of the thyroid in an adult female: one-year followup
Authors: Ramon Vilallonga, Andrea Ciudin, José Manuel Fort, Juan Antonio Baena, Oscar Gonzalez, Manuel Armengol, Jordi Mesa, Mari Carmen Ruiz Marcellán
Journal: Int J Endocrinol (2011)
MeSH terms: Case Reports

Thyroid gland involvement as the unique presentation of Langerhans cell histiocytosis is a rare phenomenon that can result in misdiagnosis. We report a case of Langerhans cell histiocytosis (LCH) presenting as a thyroid mass. It is a 52-year-old woman who presented an enlarged, diffusely firm, nontender, nonmobile, and not particularly nodular thyroid gland with mild compressive symptoms. Ultrasound and fine-needle aspiration showed a unique right node with benign signs. Patient was referred to our Ambulatory Surgery Department, where a hemithyroidectomy was performed. Histologic evaluation of the right thyroid gland revealed an involvement by LCH, confirmed by immunohistochemical analysis showing Langerhans cells that were positive for CD1a. LCH was a completely incidental occult finding apparent only after surgical resection and examination of the gland. Patient was evaluated, and no evidence of systemic affectation was found. LCH can rarely involve the thyroid gland in adults. Few cases have been reported in the literature. Most patients had evidence of LCH involving other anatomic sites.
Multidimensional sternal fixation to overcome a "floating" sternum
Authors: William Rothstein, Tyler Spata, Bryan Whitson, Ahmet Kilic
Journal: Case Rep Surg (2014)

This case report describes the repair of a complete sternal dehiscence of the lower right sternum using sternal wires, manubrial plates, and a Talon closure device for rigid, multidimensional sternal fixation. Sternal dehiscence is a rare but significant cause of morbidity for patients undergoing median sternotomy. The risk factors for this complication are well described and although sternal wires have traditionally been used for primary closure, rigid fixation with sternal plates is a viable alternative to avoid dehiscence in this high-risk cohort.
Primary Ovarian Choriocarcinoma: Rare Entity
Authors: Mequanent Tariku Adow, Shimelis Fantu Gebresilasie, Natnael Alemayehu Abebe
Journal: Case Rep Obstet Gynecol (2021)
MeSH terms: Case Reports

Background:
Primary pure ovarian choriocarcinoma is a rare aggressive tumor which can be nongestational arising from germ cells or gestational origin. Preoperative diagnosis of extrauterine choriocarcinoma is challenging due to nonspecific clinical presentation. Case Presentation. This article reports primary ovarian choriocarcinoma, likely gestational in a 25-year-old para 2 woman presenting with lower abdominal pain and swelling of two-week duration. Diagnosis was suspected by serum beta-human chorionic gonadotropin and confirmed histologically after surgery. Postoperatively, she was managed with multiple courses of chemotherapy using a bleomycin, etoposide, and cisplatin regimen, and the treatment was effective.
Conclusion:
In patients with adnexal mass presenting with nonspecific symptoms especially with high Doppler blood flow of the mass on ultrasound evaluation, serum beta-human chorionic gonadotropin determination is recommended before laparotomy. In setups where the genomic test is not available, histological and clinical effort to differentiate gestational versus nongestational choriocarcinoma is useful for specific management decision.
A Novel Approach to Sternal Fracture Repair With the Implementation of a Compression/Distraction Device
Authors: John Hulse, Evert Eriksson
Journal: Cureus (2023)
Keywords: compression / distraction devise, open fracture reduction, sternal fracture, surgical stabilization of sternal fracture, trauma
MeSH terms: Case Reports

Sternal fractures are common following blunt traumatic injury. Most sternal fractures can be managed successfully nonoperatively; however, surgical fixation should be considered in certain scenarios. Specifically, surgery may be indicated in cases of severe pain, respiratory failure or dependency on mechanical ventilation, cosmetic deformity, malunion, disunion, and compression of the heart. A variety of surgical approaches to sternal fracture fixation have been documented (steel wire, suture materials, a seven-hole aluminum plate, an eight-holed Sternolock X plate, sternum-osteosynthesis plate, t-shaped plate); however, few techniques have been discussed for the initial reduction of the sternal fracture prior to fixation. In this paper, we describe a novel surgical technique used to reduce sternal fractures and approximate the edges of the sternum using a compression/distraction device.
Colorectal Cancer Related to Chronic Strongyloides stercoralis Infection
Authors: M Sava, T Huynh, A Frugoli, L Kong, M Salehpour, B Barrows
Journal: Case Rep Gastrointest Med (2020)
MeSH terms: Case Reports

The majority of individuals with Strongyloides stercoralis (S. stercoralis) colitis are clinically asymptomatic. Symptomatic individuals may complain of nonspecific gastrointestinal symptoms, such as abdominal pain, intermittent or persistent diarrhea, nausea, or loss of appetite. In addition, skin manifestations such as recurrent urticaria can occur. If infection is not diagnosed and left untreated, it can lead to chronic inflammation of the gastrointestinal tract. It is well documented that chronic colitis such as inflammatory bowel disease can predispose individuals to colorectal cancer. Additionally, there is evidence of chronic parasitic infections inducing the development of cancers in other organs within the gastrointestinal tract. In this case vignette, we describe a case of chronic Strongyloides stercoralis infection in a Peruvian woman presenting with colorectal cancer.
Novel compound heterozygous CDH23 variants in a patient with Usher syndrome type I
Authors: Satomi Okano, Yoshio Makita, Akihiro Katada, Yasuaki Harabuchi, Tomohiro Kohmoto, Takuya Naruto, Kiyoshi Masuda, Issei Imoto
Journal: Hum Genome Var (2019)
MeSH terms: Case Reports

Usher syndrome type I (USH1) is characterized by congenital, bilateral, profound sensorineural hearing loss, vestibular areflexia, and adolescent-onset retinitis pigmentosa. Here, we report a 12-year-old female patient with typical USH1. Targeted panel sequencing revealed compound heterozygous variants of the Cadherin 23 (CDH23) gene, which confirmed the USH1 diagnosis. A novel NM_022124.5:c.130G>A/p.(Glu44Lys) was identified, expanding the mutation spectrum of CDH23.
Recurrent renal secondary hyperparathyroidism caused by supernumerary mediastinal parathyroid gland and parathyromatosis: A case report
Authors: Longfei Li, Chenchen He, Guangming Cheng, Junying Cao, Chunhui Wang, Yufu Tang, Wei Zhang
Journal: Front Surg (2023)
Keywords: case reports, hyperparathyroidism, parathyromatosis, recurrence, secondary, supernumerary parathyroid glands
MeSH terms: Case Reports

Background:
Surgical parathyroidectomy (PTX) is necessary for patients with severe and progressive secondary hyperparathyroidism (SHPT) refractory to medical treatment. Recurrence of SHPT after PTX is a serious clinical problem. Both supernumerary mediastinal parathyroid gland and parathyromatosis are the rare causes of recurrent renal SHPT. We report a rare case of recurrent renal SHPT due to supernumerary mediastinal parathyroid gland and parathyromatosis.
Case presentation:
A 53-year-old man underwent total parathyroidectomy with autotransplantation due to the drug-refractory SHPT 17 years ago. In the last 11 months, the patient experienced symptoms including bone pain and skin itch, and the serum intact parathyroid hormone (iPTH) level elevated to 1,587 pg/ml. Ultrasound detected two hypoechoic lesions located at the dorsal area of right lobe of the thyroid gland, and both lesions presented as characteristics of hyperparathyroidism in contrast-enhanced ultrasound. 99mTc-MIBI/SPECT detected a nodule in the mediastinum. A reoperation involved a cervicotomy for excising parathyromatosis lesions and the surrounding tissue and a thoracoscopic surgery for resecting a mediastinal parathyroid gland. According to a histological examination, two lesions behind the right thyroid lobe and one lesion in the central region had been defined as parathyromatosis. A nodule in the mediastinum was consistent with hyperplastic parathyroid. The patient remained well for 10 months with alleviated symptoms and stabilized iPTH levels in the range of 123-201 pg/ml.
Conclusion:
Although rare, recurrent SHPT may be caused by a coexistence of both supernumerary parathyroid glands and parathyromatosis, which should receive more attention. The combination of imaging modalities is important for reoperative locations of parathyroid lesions. To successfully treat parathyromatosis, all the lesions and the surrounding tissue must be excised. Thoracoscopic surgery is a reliable and safe approach for the resection of ectopic mediastinal parathyroid glands.
First Case Report of Prader-Willi-Like Syndrome in Colombia
Authors: Estephania Candelo, Max M Feinstein, Diana Ramirez-Montaño, Juan F Gomez, Harry Pachajoa
Journal: Front Genet (2018)
Keywords: 6q161–q21 deletion, prader–willi syndrome (pws), prader–willi-like phenotype, prader–willi-like syndrome, pediatric obesity
MeSH terms: Case Reports

Background: Prader-Willi-like syndrome (PWLS) is believed to be caused by a variety of disruptions in genetic pathways both inside and outside of the genetic region implicated in PWS. By definition, PWLS does not demonstrate mutations in the 15q11-q13 region itself. It is a rare disorder whose clinical hallmarks include hypotonia, obesity, short extremities, and delayed development. This syndrome has been described in patients with 1p, 2p, 3p, 6q, and 9q chromosome abnormalities and in cases with maternal uniparental disomy of chromosome 14 and fragile X syndrome. Case presentation: In the present report, we describe a 9-year-old Colombian patient who demonstrated features of PWS and was ultimately diagnosed with PWLS after genetic analysis revealed a 14.97 Mb deletion of 6q16.1-q21. Conclusions: This is the first reported case of PWLS in Colombia and represents one of the largest documented 6q21 deletions.
En Bloc Resection of Primary Large Esophageal Mucosa-Associated Lymphoid Tissue Lymphoma by Endoscopic Submucosal Dissection: A Case Report
Authors: Yujia Xia, Yu Wang, Jian Han, Mei Liu
Journal: Front Med (Lausanne) (2021)
Keywords: endoscopic submucosal dissection, esophagus, mucosa-associated lymphoid tissue lymphoma, pathology, treatment
MeSH terms: Case Reports

Treatment of mucosa-associated lymphoid tissue (MALT) lymphoma has recently received considerable attention. Here, we report a case of large esophageal MALT lymphoma that was successfully en bloc resected using endoscopic submucosal dissection (ESD). A 77-year-old woman was admitted to our hospital with progressive dysphagia for more than 2 months. Upper gastrointestinal endoscopy revealed a large rounded submucosal mass covered by normal mucosa, located at the lower esophagus. Endoscopic ultrasonography (EUS) showed a well-demarcated hypoechoic mass chiefly located in the esophageal wall, but the layers of the esophageal wall were not clear. ESD was performed for diagnostic and treatment purposes. No complications occurred during or after ESD. The resected specimen measured 4.3 cm × 2.8 cm × 1.5 cm. The histologic findings were diagnostic of esophageal MALT lymphoma. Infiltration of neoplastic cells in the lateral margins of the resected specimen was not observed. However, vertical margins showed an R1 situation and mild damage to the muscularis propria. After 3 months, her dysphagia disappeared. Additional radiation therapy was then administered. After 5 months, the patient was still under surveillance and free of recurrent disease. Resection with ESD of such a large mass of MALT in the esophageal region has rarely been reported before in the literature.
Delayed Diagnosis of Pharyngeal Perforation following Exploding Tyre Blast Barotrauma
Authors: Samantha M Field, Joseph G Manjaly, S Krishan Ramdoo, Huw A S Jones, Taran S Tatla
Journal: Case Rep Otolaryngol (2014)

Introduction. Pharyngoesophageal perforation secondary to barotrauma is a rare phenomenon that can have serious complications if identified late. It is challenging to detect due to nonspecific symptoms. We present a case in which detection proved difficult leading to delayed diagnosis. Case Report. A 27-year-old mechanic presented with haemoptysis, dysphonia, and odynophagia after a car tyre exploded in his face. Flexible nasoendoscopy (FNE) revealed blood in the pharynx, thought to represent mucosal haemorrhage. Initial treatment consisted of IV dexamethasone and antibiotics. After 3 days, odynophagia persisted prompting a CT scan. This revealed a defect in the posterior hypopharynx and surgical emphysema in the deep neck tissues. Contrast swallow confirmed posterior hypopharyngeal leak. NG feeding was commenced until repeated contrast swallow confirmed resolution of the defect. Discussion. Prompt nonsurgical management of pharyngoesophageal perforation has good outcomes but untreated perforation can have serious complications. FNE should be performed routinely, but only a contrast swallow can diagnose a functional perforation. Clinicians should have a high index of clinical suspicion when patients present with barotrauma and odynophagia. Patients should be kept nil by mouth until perforation has been excluded. Conclusion. When faced with cases of facial barotrauma, clinicians should have a low threshold for further imaging to exclude pharyngoesophageal perforation.
Case Report: Successful therapy with all- trans retinoic acid combined with chemotherapy followed by hematopoietic stem cell transplantation for acute promyelocytic leukemia carrying the BCOR-RARA fusion gene
Authors: Li Chen, Hongming Zhu, Yongmei Zhu, Wen Jin, Fangyi Dong, Jianfeng Li, Jiong Hu, Qiusheng Chen, Kankan Wang, Junmin Li
Journal: Front Oncol (2022)
Keywords: bcor-rara, acute promyelocytic leukemia, all-trans retinoic acid, allogeneic hematopoietic stem cell transplantation, variant
MeSH terms: Case Reports

Acute promyelocytic leukemia (APL) is characterized by the balanced translocation of chromosomes 15 and 17, resulting in the formation of PML-RARA fusion gene. More than 98% of APL have PML-RARA fusion, and less than 2% have other types of RARA gene partners, which named variant APL (vAPL). In the present study, we reported a vAPL with BCOR-RARA, which was the third case of BCOR-RARA APL published. The patient achieved complete remission (CR) with all-trans retinoic acid (ATRA) monotherapy, and molecular CR with ATRA plus standard chemotherapy. After that, he underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) and ATRA maintenance and maintained a molecular CR status. This case provided valuable insights into the accurate identification of vAPL. Moreover, ATRA combined with chemotherapy followed by allo-HSCT was suggested as an optimal choice for those vAPL patients who had a high risk of relapse.
Intraoperative breakage of Sachse's knife blade: A rare complication of optical internal urethrotomy (one case managing experience)
Authors: Gautam Kumar Kanodia, Satyanarayan Sankhwar, Ankur Jhanwar, Ankur Bansal, Manoj Kumar, Ashok Gupta
Journal: Int Braz J Urol (2017)
Keywords: methods, recurrence, urethra
MeSH terms: Equipment Failure, Intraoperative Complications / etiology, Surgical Instruments, Urethral Stricture / surgery, Urologic Surgical Procedures, Male / adverse effects, Urologic Surgical Procedures, Male / instrumentation, Case Reports, Adult, Cystoscopy / methods, Fluoroscopy / methods, Humans, Intraoperative Complications / surgery, Male, Urethra / diagnostic imaging, Urethra / surgery

Optical internal urethrotomy (OIU) is the most common procedure performed for short segment bulbar urethral stricture worldwide. This procedure most commonly performed using Sachse's cold knife. Various perioperative complications of internal urethrotomy have been described in literature including bleeding, urinary tract infection, extravasation of fluid, incontinence, impotence, and recurrence of stricture. Here we report a unique complication of breakage of Sachse knife blade intraoperatively and its endoscopic management.
Asynchronous Bilateral Ovarian Torsion: Three Cases, Three Lessons
Authors: M C Lucchetti, C Orazi, A Lais, M L Capitanucci, P Caione, H Bakhsh
Journal: Case Rep Pediatr (2017)
MeSH terms: Case Reports

Background:
Ovarian torsion (OT) is a serious condition, and delay in surgical intervention may result in loss of the ovary. Children and adolescents who have suffered from ovarian torsion may be at risk for asynchronous torsion of the contralateral ovary.
Study objective:
Three cases of asynchronous bilateral ovarian torsion were reported to analyse clinical history of three patients, to review the current literature, and to draw a conclusion for future treatment.
Design:
Case reports and review of the literature.
Result:
When a prepubertal girl presents with an ovarian torsion, several considerations have to be taken in account in order to preserve her future fertility; in particular, the pediatric surgeon/gynecologist has to preserve as much as possible the twisted ovary in addition to considering the fate of the contralateral ovary.
Summary and conclusions:
Pelvic pain in a young girl has always raised the clinical suspect of an ovarian torsion; the possibility of asynchronous bilateral ovarian torsion is rare, but it is described in the literature and has catastrophic consequences; this condition has to be known and treated in the proper way by pediatric surgeons as well as by gynecologists in order to maximize the future fertility of the young patients.