OpenMed/multicare-articles huggingface dataset:
Endoluminal rescue of false lumen graft deployment in TEVAR for type B aortic dissection: a case report and literature review
Authors: Hong Jiang Zhu, Feng Yan, Peng Peng Zhao
Journal: Front Cardiovasc Med (2024)
Keywords: tevar, aortic, aortic dissection, case report, stent graft misdeployment
MeSH terms: Case Reports

Background:
Thoracic endovascular aortic repair (TEVAR) has increasingly become the preferred surgical intervention for Stanford type B aortic dissection (TBAD). The primary objective of this procedure is to seal the primary entry tear to promote positive aortic remodeling. However, the increased use of TEVAR has also led to a rise in surgical complications. Among these, the accidental deployment of the stent into the false lumen is a rare but serious complication that can result in aortic false lumen rupture and inadequate perfusion of abdominal organs.
Case summary:
This case report described a 78-year-old man who presented to our hospital with sudden onset chest and back pain and was subsequently diagnosed with TBAD via aortic CTA. As conventional medical therapy failed to alleviate his chest pain, the patient underwent TEVAR. During the procedure, a complication arose when the distal end of the endograft was mistakenly deployed into the false lumen, leading to insufficient perfusion of the abdominal organs. Recognizing this issue intraoperatively, an additional endograft was promptly inserted at the distal end to reroute blood flow back to the true lumen of the aorta, thereby restoring visceral perfusion. Post-intervention, the patient's chest pain improved, and he was successfully discharged from the hospital.
Conclusion:
Accidental deployment of a endograft into the false lumen during TEVAR is a rare but serious complication. Intraoperative angiography plays a crucial role in rapidly and accurately identifying this issue by detecting insufficient perfusion of abdominal organs. The use of intravascular ultrasound may help reduce the incidence of this complication. Endovascular repair is an effective emergency strategy to quickly redirect blood flow back to the true lumen, making it the preferred method for managing such emergencies.
Case report of snaring-assisted TAVR under cerebral embolic protection: the "Chaperone" with "Top Hat" technique
Authors: Massimo Medda, Francesco Casilli, Marta Bande, Maurizio Tespili, Francesco Donatelli
Journal: Front Cardiovasc Med (2023)
Keywords: aortic valve stenosis, cerebral protection devices, chaperone technique, snare catheter, transcatheter aortic valve replacement (tavr)
MeSH terms: Case Reports

Symptomatic severe aortic stenosis (AS) in patients with intermediate-to-high surgical risk is currently being treated with transcatheter aortic valve replacement (TAVR). We present a case of a TAVR in a severe calcific AS with porcelain aorta and 'gothic' aortic arch. Pre-operative thoraco-abdominal computed tomography angiography showed also severe calcification at the sinotubular junction with protruding huge calcified nodules extending in ascending aorta and multiple calcific stenosis of both iliac-femoral vessels, severely tortuous. The choice of the interventional access was not easy and the high risk of an acute intra-procedural brain event guided the procedural planning. To our knowledge, this is the first case of TAVR with complete cerebral protection with Triguard system device and 'snaring-assisted' valve advancement.
Link Workers in Social Prescribing for Young People Work: A Case Study From Sheffield Futures
Authors: Isabel Farina, Marcello Bertotti, Cristina Masella, Daniela Sangiorgi
Journal: Int J Integr Care (2024)
Keywords: children and young people, link workers, social prescribing
MeSH terms: Case Reports

Introduction:
Social Prescribing has an established recognition regarding the benefits provided to the health-related social needs of adults, but little is known about how the intervention addresses young people's needs. There is optimism regarding the central role of two core mechanisms that allows social prescribing to be effective, such as the empathetic role of Link Workers and the connection with community resources.This paper aims to describe the role played by Link Workers working a Social Prescribing intervention targeting young people.
Description:
This paper adopts a case study methodology to describe the role of Link Workers addressing young people's needs and implementing Social Prescribing scheme in Sheffield (UK). Data were collected through semi-structured interviews with four of the seven link workers of one organisation based in Sheffield. Data were analysed through an inductive approach for emerging themes.
Discussion:
We provided a description of the profiles and background of Link Workers and described the three models of referral pathways into the intervention. The paper also shows how Link Workers identify young people's needs and how they connect with the community.
Conclusion:
Based on the insights and the internationally accepted definition of Social Prescribing, we provide a visual representation of the Social Prescribing model and discuss challenges. The paper highlights lessons learned and future directions regarding the role of Link Workers from the case study.
Acute post-renal kidney graft dysfunction due to cytomegalovirus-positive nephrogenic adenoma-case report and review of the literature
Authors: Nicola Hosek, Matteo Montani, Laila-Yasmin Mani
Journal: Front Med (Lausanne) (2024)
Keywords: allograft dysfunction, case report, cytomegalovirus, infection, kidney transplantation, nephrogenic adenoma, post-renal, urologic complication
MeSH terms: Case Reports

Tissue-invasive cytomegalovirus (CMV) disease represents a well-recognized complication after kidney transplantation. However, direct involvement of the urogenital tract and CMV-ureteritis occur less frequently. Nephrogenic adenomas are benign lesions of the urinary tract preferentially reported in kidney transplant recipients. We herein report a second case of a 33-year-old male kidney transplant recipient with acute post-renal allograft dysfunction due to CMV-positive ureteral nephrogenic adenoma. A causal connection might be suspected but remains to be proven.
Neonatal Skull Depression: The Role of Cranial Ultrasound
Authors: André Assunção, Filipa Flor-de-Lima, Josué Pereira, Daniela Pinto
Journal: Cureus (2024)
Keywords: cranial ultrasound, diagnostic modalities, neonatal skull depression, newborn, skull defects
MeSH terms: Case Reports

Nontraumatic congenital neonatal skull depression is a rare condition resulting from external forces shaping the fetal skull. Typically, newborns are asymptomatic, and, usually, the condition resolves in a few months with no need for intervention. However, many newborns undergo a CT scan, an ionizing technique, to check for fractures or intracranial lesions. We report a case of congenital skull depression without neurological deficits, managed conservatively through clinical monitoring and ultrasound.
Early medieval vernacular Celtic glosses: originals or translations? A case study on the Vienna Bede
Authors: Bernhard Bauer
Journal: Open Res Eur (2024)
Keywords: computus, early medieval celtic languages, early medieval latin, glossing traditions, multilingualism, old irish, venerable bede

This study investigates the Old Irish glossing tradition on the Venerable Bede's De Temporum Ratione, a computistical work from the early eighth century. Its main source is the Vienna Bede, a fragmentary manuscript with Old Irish and Latin glosses dating from the late eighth/early ninth centuries. It focuses on parallel glosses found in the Gloss-ViBe corpus where the Vienna Bede has an Old Irish gloss and the other manuscripts feature glosses in another language (Latin or Old Breton/Welsh). Minute analysis of individual glosses is used to determine whether early medieval vernacular Celtic glosses originals or translations from Latin glosses? The heterogenic nature of early medieval gloss corpora makes this a complex question for which there is no straightforward answer: for some glosses, a translation from Latin into Irish is almost inevitable, but others suggest Irish influence on the Latin parallel glosses. Accordingly, each case is discussed individually and the results are synthesised in the final part of the article.
Orofacial Granulomatosis among Pediatric Patients Well Controlled by Corticosteroid Treatment: A Rare Case Series
Authors: Taku Kimura, Ken-Ichiro Sakata, Shunichiro Takezaki, Takuya Asaka, Shohei Oshima, Aya Yanagawa-Matsuda, Yoshimasa Kitagawa
Journal: Case Rep Pediatr (2024)
MeSH terms: Case Reports

Orofacial granulomatosis (OFG) is a rare disease entity characterized by nonnecrotizing granulomatous inflammation in the oral and maxillofacial regions, typically characterized by recurrent or persistent edema, primarily in the lips and occasionally in the gingiva. OFG is often associated with Crohn's disease and sarcoidosis, and an accurate diagnosis requires systemic examination of patients. Pediatric patients possess unique oral conditions where dental plaque rapidly forms, especially during tooth replacement due to tooth crowding. Moreover, controlling oral hygiene can be challenging, rendering it difficult to distinguish plaque-induced gingivitis from nonplaque-induced gingivitis. We elucidate the reports of pediatric patients who developed OFG in the lips and/or gingiva alone, which was well controlled through corticosteroid treatment. The patients demonstrated recurrent lips and/or gingival swelling with redness, which failed to improve despite oral health care and treatment with antibiotics and/or corticosteroid ointment. Incision biopsy was performed, which demonstrated granulomatous inflammation. Further systemic examination ruled out Crohn's disease and sarcoidosis and confirmed OFG diagnosis. Corticosteroid treatment orally or through gargling was administered to the patients, which provided improvement of symptoms after 1 month. As OFG may be associated with intractable diseases, monitoring the patient regularly is crucial. Pediatric patients with OFG require a collaborative approach with pediatricians and pediatric dentists to manage their oral and overall health.
Case studies of multi-disciplinary team management of atypical gastric cancer: challenges and lessons learned (about two cases)
Authors: Mbang Kooffreh-Ada, Obinna Ebere Iheanacho, Victor Ikechukwu Nwagbara, Komommo Okoi Okpebri, Chukwuemeka Okechukwu Anisi, Asa Itam-Eyo, Okezie Uba-Mgbemena, Oliver Emmanuel Ali, Ofonime Benjamin Essien, Akintunde Olusijibomi Akintomide, Michael Eteng Eyong, Emmanuel Edet Effa, Ngim Ewezu Ngim
Journal: Pan Afr Med J (2023)
Keywords: atypical, case report, gastric cancer, management challenges, multidisciplinary team
MeSH terms: Drug-Related Side Effects and Adverse Reactions, Stomach Neoplasms / diagnosis, Stomach Neoplasms / therapy, Case Reports, Hospitals, Humans, Nigeria, Physical Examination

There is a paradigm shift towards adopting a multidisciplinary team (MDT) model in the care of cancer patients, with increasing evidence to support its effectiveness. Cancers are biologically distinct, patients present in diverse ways and require, different therapeutic approaches in their management. Patient symptoms and treatment side-effects as well as physical and psychological impact vary according to cancer location and treatment plan. The varied clinical scenarios cancer patients present further buttress the need for MDT practice in hospitals to improve the quality of patient care, in contrast to the outdated concept of holistic treatment offered by a single physician. Unlike Europe, United States of America and Australia which have implemented successful MDT cancer care programs, Nigeria is just coming on board. We present two cases of gastric cancer (seen two months apart) with atypical presentation and the role of MDT in their evaluation and management. These case studies highlight the role of MDT in the management of cancer patients in Nigeria lending credence to the urgent need to implement this model of care in our cancer patients in a bid to improve the quality of care and outcome.
Case Report: A case of disseminated cutaneous listeriosis following appendicitis from Lao PDR
Authors: Terry John Evans, Vannavong Siratana, Timothy Venkatesan, Viengmon Davong, Khamphong Thanadabouth, Elizabeth A Ashley
Journal: Wellcome Open Res (2024)
Keywords: laos, listeria, bacteraemia, food-borne, meningitis, pustular rash, sarcoidosis, southeast asia
MeSH terms: Case Reports

Background:

Listeria monocytogenes is a food-borne pathogen that is a rare cause of bacteraemia and meningitis in immunosuppressed patients, and carries a high mortality rate. Cutaneous manifestations of listeriosis are rare, and are usually associated with direct inoculation of the skin.
Case:
A 41-year-old woman who initially presented to a hospital in Laos with appendicitis was diagnosed with disseminated listeriosis with cutaneous involvement. Intra-abdominal pathology probably contributed to bacterial bloodstream invasion. Initial treatment with meropenem was switched to ampicillin based on best practice, however our patient died 5 days after diagnosis.
Conclusions:
This case highlights listeriosis as an important cause of mortality in low- and middle-income countries, exacerbated by poor availability of laboratory diagnostics and ineffective empiric antibiotic regimens. Improvements in food hygiene, surveillance, and increased laboratory capacity are important strategies to reduce rates of infection and clinical outcomes.
COVID-19-related multisystem inflammatory syndrome in adult: the first death in Brazil
Authors: Maria Lúcia Machado Salomão, Flávia Queiroz, Lina de Moura Mendes, Taiza Maschio de Lima, Murillo de Souza Tuckumantel, Marcia Wakai Catelan, Neymar Elias de Oliveira, Maurício Lacerda Nogueira, Cassia Fernanda Estofolete
Journal: Rev Inst Med Trop Sao Paulo (2023)
MeSH terms: COVID-19, Severe Dengue, Case Reports, Adult, Brazil, Hospitalization, Humans, Male, United States, adult multisystem inflammatory disease, COVID-19 related

The precise pathogenesis of COVID-19-related multisystem inflammatory syndrome remains largely elusive, despite its rarity. The syndrome symptoms often overlap with those of other infections, posing challenges for prompt diagnosis. A male patient, 34 years old, was admitted with suspicion of severe dengue, rapidly progressing to multiple organ dysfunction. Dengue tests resulted negative, and he passed away after four days. This case occurred approximately four weeks after the initial onset of COVID-19 and met all diagnostic criteria as defined by the Centers for Disease Control and Prevention. This report presents the first documented case of fatal multisystem inflammatory syndrome in adult (MIS-A) in Brazil. Recognizing the significance of suspecting this syndrome and promptly initiating treatment at an early stage are essential for minimizing damage and mortality.
Minimally Invasive Revision of Luque Plate Instrumentation: A Case Report
Authors: Peter B Derman, Mary P Rogers-LaVanne, Alexander M Satin
Journal: Cureus (2024)
Keywords: bone plates, lumbar vertebrae, pedicle screws, reoperation, spinal fusion, spinal stenosis
MeSH terms: Case Reports

Extension of existing spinal fusions may necessitate the removal of or linkage to prior constructs. Knowledge of previously placed instrumentation is critical to success in these revision scenarios. The Luque spinal instrumentation system, developed in the late 1980s, is a legacy pedicle screw and plate system that may be encountered during revision operations today. A 67-year-old male with a remote history of L4-S1 fusion with Luque instrumentation presented with bilateral lower extremity neurogenic claudication due to adjacent segment disease at L3-4. Decompression and extension of fusion to the L3-4 level were performed using minimally invasive techniques. Of note, posterior instrumentation was extended by removing prior L4 pedicle screws with a 7 mm female hexagonal driver through tubular retractors, leaving the Luque plates in place, placing modern pedicle screws at L4 (through the plates) and L3, and linking these with standard rods. The surgery and post-operative course were uncomplicated, and the patient experienced complete resolution of his pre-operative claudication symptoms. Extension of prior Luque plate instrumented fusion can be accomplished minimally invasively without removing the plates themselves, resulting in greater operative efficiency and less surgical morbidity.
Acute generalized exanthematous pustulosis induced by icotinib: a case report and literature review
Authors: Wei Yang, Jiayu Zhao, Jun Niu
Journal: Front Pharmacol (2024)
Keywords: acute generalized exanthematous pustulosis, adverse drug reactions, icotinib, non-small cell lung cancer, tyrosine kinase inhibitor
MeSH terms: Case Reports

Acute generalized exanthematous pustulosis, an infrequent adverse drug reaction, mainly results from drugs. Clinically, acute generalized exanthematous pustulosis manifests as a high fever, with skin lesions of small monomorphic subcorneal sterile pustules on an erythematous that presents at 1-4 days after medication exposure. The incidence of acute generalized exanthematous pustulosis varies from 3/1, 000, 000 to 5/1, 000, 000, while the mortality rate is typically around 5%. We present a case of a 69-year-old female who developed a diffuse, erythematous, pustular rash over the entire body and exhibited a fever of 38.3°C after 4 days of icotinib therapy. Considering her medication history and the appearance of the lesions, she was diagnosed with acute generalized exanthematous pustulosis and received appropriate treatment. We also conducted a literature review through PubMed to compare similarities and differences between our case and those reported in the literature.
Fatal acute-on-chronic liver failure following camrelizumab for hepatocellular carcinoma with HBsAg seroclearance: a case report and literature review
Authors: Fenghui Li, Tao Wang, Fei Tang, Jing Liang
Journal: Front Med (Lausanne) (2023)
Keywords: clearance of hbsag, hepatitis b, immune checkpoint inhibitors (icis), immune-mediated liver injury caused by checkpoint inhibitors (ilici), liver failure
MeSH terms: Case Reports

In the last few years, immune checkpoint inhibitors (ICIs) have become major therapeutic agents for the treatment of advanced hepatocellular carcinoma (HCC). However, immunotherapy can activate hepatitis B virus (HBV), and immune clearance may lead to liver failure and even life-threatening conditions. Here we report a case of HCC with HBV-related cirrhosis that caused severe liver injury and rapidly progressed to fatal acute-on-chronic liver failure (ACLF) after only once application of camrelizumab; the patient underwent serological conversion of hepatitis B surface antigen (HBsAg) with liver injury. The patient's condition progressed rapidly. We added corticosteroids and applied plasma dialysis, along with tenofovir alafenamide (TAF) to control HBV. However, the patient eventually died of liver failure. To our knowledge, there are few reports of HBsAg clearance due to ICIs accompanied by fatal acute-on-chronic liver failure shortly after ICIs initiation. These results suggest that ICIs can cause fatal liver injury in a short term; in patients with chronic HBV infection, ICIs use may promote serological conversion of HBsAg.
Case report: A novel somatic SDHB variant in a patient with bladder paraganglioma
Authors: Thao Nguyen, Zehra Ordulu, Sunaina Shrestha, Urja Patel, Paul L Crispen, Lisa Brown, Sara M Falzarano, Hans K Ghayee, Juan Pablo Perdomo Rodriguez
Journal: Front Endocrinol (Lausanne) (2024)
Keywords: sdhb, bladder paraganglioma, c642g>a, leiomyoma, pq214q, paraganglioma
MeSH terms: Paraganglioma / genetics, Paraganglioma / pathology, Succinate Dehydrogenase / genetics, Urinary Bladder Neoplasms / genetics, Urinary Bladder Neoplasms / pathology, Case Reports, Adult, Female, Humans, Mutation, SDHB protein, human, Succinate Dehydrogenase

Background:
Paragangliomas (PGL) are rare neuroendocrine tumors derived from the autonomic nervous system paraganglia. Urinary bladder paragangliomas (UBPGL) originate from the sympathetic neurons of the urinary bladder wall and represent 0.7% of all paragangliomas and <0.05% of all bladder tumors. PGL and UBPGL can be associated with SDHB, SDHD, NF1, and VHL gene variants, with the most common germline alterations found in SDHB and VHL.
Case report:
We report a case of a 42-year-old woman who presented with menorrhagia/hematuria, uterine leiomyomas, as well as cardiac and bladder masses. The cardiac mass was favored to be a myxoma based on clinical findings, while the bladder mass was diagnosed as UBPGL. A novel SDHB mutation (c.642G>A, p Q214Q), detected in the UBPGL, was proven to be somatic. Although this variant was seemingly synonymous, it was predicted to have a loss of function due to the splice site effect, which was further supported by the immunohistochemical loss of SDHB.
Conclusion:
This case highlights the challenges of diagnosing an extremely rare entity, bladder paraganglioma, with an emphasis on the multidisciplinary approach to navigate various clinical and imaging findings that may initially be misleading. In addition, a novel loss of function SDHB variant that could have been overlooked as a synonymous variant is herein reported, while also illustrating the importance of both germline and somatic mutation testing.
Oral manifestation as the only sign of Langerhans cell histiocytosis: A case report
Authors: Bahareh Nazemisalman, Mobina Sadat Zarabadi
Journal: Clin Case Rep (2024)
Keywords: langerhans cell histiocytosis, oral manifestation, pediatric dentistry
MeSH terms: Case Reports

Key clinical message:
The manifestations of Langerhans cell histiocytosis can be limited in the oral cavity, including gingival recession, tooth mobility, and bone destruction. Dentists play a crucial role in the early detection and management of these oral symptoms, which can significantly impact the overall prognosis and quality of life for patients with this serious disease.
Abstract:
The hyperplastic activity of bone marrow can lead to excessive histocyte proliferation, called Langerhans cell histiocytosis (LCH). Based on the accumulation location, it has various organ involvement, including skin, bone, and so forth. Oral manifestations such as tooth involvement, bone lesions, mucosal ulcers, and periodontal problems can occur, and they might be the only manifestation of LCH. A subtle diagnosis is crucial and can be started with dental examinations. A 5-year-old girl was examined with the chief complaint of gingival recession with no pain, caries, or calculus. The clinical and radiographical assessment led to further immunohistochemical (IHC) evaluations. The diagnosis was LCH based on S-100 and cluster of differentiation 1a (CD1a) markers. LCH can involve different cells and tissues locally or generally. The early detection and treatment of LCH increase children's survival rate and quality of future life. Therefore, an accurate diagnosis is important among dentists. They must consider that abnormal mobility, gingival, or periodontal problems with no logical cause might warn about a latent problem. Sometimes extraction of loose teeth is not the end of treatment; it is the start of neglecting a serious disease.