OpenMed/multicare-articles huggingface dataset:
Oral Squamous Cell Carcinoma in a Patient with Fanconi Anemia
Authors: Milla Huuhka, Aaro Turunen
Journal: Case Rep Dent (2021)
MeSH terms: Case Reports

Fanconi anemia (FA) is a rare autosomal recessive genetic disorder characterized by different types of malformations, skin lesions, bone marrow failure, and increased risk for both hematological malignancies and solid tumors, especially head and neck squamous cell carcinomas (HNSCC). FA patients may also display a low tolerance to oncologic treatments. The authors present a case of mandibular squamous cell carcinoma in a young FA patient. Because of the aggressive nature of the SCC and complex treatment options, we recommend a strict lifelong follow-up for all FA patients to detect early changes in the oral mucosa.
A case of rare pulmonary sequestration complicated with congenital heart disease treated by arterial embolization and atrial defect closure: A case report and review of literature
Authors: Mi Tang, Xun Wu, Shijun Hu, Qin Wu, Danni Yang, Chukwuemeka Daniel Iroegbu, Chengming Fan, Jinfu Yang
Journal: Front Cardiovasc Med (2022)
Keywords: atrial septal defect, atrial septal occlusion, interventional therapy, pulmonary sequestration, pulmonary vein drainage
MeSH terms: Case Reports

Pulmonary sequestration with congenital heart disease is a rare congenital malformation. Herein, we report a 19-month-old toddler diagnosed with right lower pulmonary sequestration, right pulmonary artery dysplasia, right lower pulmonary venous ectopic drainage, and a right-sided heart with an atrial septal defect. The pulmonary sequestration had a rare blood supply, such as confluent arteries with the renal vessels draining into the hepatic veins. Arterial embolization and atrial defect closure were used to treat the rare congenital malformation with satisfactory results.
Case report: Heterotopic intrarenally located adrenocortical oncocytoma
Authors: Konstantin Godin, Nicole Bang, Yuri Tolkach
Journal: F1000Res (2014)

The clinical case of a 65-year-old woman with an incidentally detected left-sided mass in the upper renal pole is presented. A functional adrenal tumor was excluded. The mass was removed retroperitoneoscopically. The perioperative period was uneventful. The histopathological examination revealed a heterotopic intrarenal adrenocortical oncocytoma. Adrenal oncocytic neoplasms are very rare, with, to the authors' knowledge, only 159 described cases so far. Most cases are non-functioning adenomas that can reach a considerable size. Only 10 heterotopic adrenal oncocytomas have been described (three retroperitoneal and seven intraspinal cases). Although the intrarenal adrenal rest is the most frequently appearing variant of adrenal heterotopia, to the best of our knowledge, this report is the first description of an intrarenally growing adrenocortical oncocytic adenoma. In addition to retroperitoneally located oncocytomas, this case could be interesting for urological practice because there are no diagnostic features which could provide a secure preoperative diagnosis of an adrenal oncocytic neoplasm and its malignant variant. Generally accepted indications for surgery of adrenal masses have to be respected. The definitive pathologic diagnosis is in most cases surprising because of its rarity. Benign adrenal oncocytic neoplasms do not require any adjuvant treatment. The oncocytic variant of adrenocortical carcinoma generally has a poor prognosis.
Bouveret's Syndrome: 64-Slice CT Diagnosis and Surgical Management-A Case Report
Authors: Dinesh Sharma, Rajan Sood, Ashwani Tomar, Anupam Jhobta, Shruti Thakur, R G Sood
Journal: Case Rep Radiol (2012)

Gastric outlet obstruction caused by duodenal impaction of a large gallstone migrated through a cholecystoduodenal fistula has been referred to as Bouveret's syndrome. We present a case of gallstone-induced duodenal obstruction in an elderly female patient, diagnosed on a 64-slice MDCT scanner. One-stage surgery, that is, stone removal and cholecystectomy, was performed resulting in relief of obstruction and complete cure. Clinical features, multidetector computed tomography (MDCT) findings, and surgical management are discussed.
TFE3 Translocation-Associated Renal Cell Carcinoma Presenting as Avascular Necrosis of the Femur in a 19-Year-Old Patient: Case Report and Review of the Literature
Authors: T Nelius, I Al-Khalil, J Vordermark, K Rinard-Holden, T Cammack, V Mamlok, S Filleur
Journal: Case Rep Med (2011)
MeSH terms: Case Reports

In the United States, renal cell carcinoma (RCC) accounts for approximately 3% of adult malignancies and 90-95% of all neoplasms arising from the kidney. According to the National Cancer Institute, 58 240 new cases and 13 040 deaths from renal cancer will occur in 2010. RCC usually occurs in older adults between the ages of 50 and 70 and is rare in young adults and children. We describe a case of a TFE3 translocation-associated RCC in a 19-year-old patient presenting as avascular necrosis of the femur. Due to the rarity of this malignancy, we present this case including a review of the existing literature relative to diagnosis and treatment.
Incidentally detected lymphatic filariasis in a renal allograft recipient
Authors: A V Vanikar, K S Suthar, V B Kute, S J Rizvi, H L Trivedi
Journal: Int J Organ Transplant Med (2013)
Keywords: lymphatic filariasis, lymphocele, renal transplantation
MeSH terms: Case Reports

Post-transplntation lymphocele is a well known complication, and lymphatic filariasis (LF) has occasionally been found to present as post-transplantation lymphocele. However, incidentally detected LF during transplantation surgery has not been reported. We present an incidentally detected LF presenting as enlarged lymph node in the right iliac fossa of a recipient during transplantation of donor kidney. He was subsequently treated after transplantation and had stable graft function without any complications after 8 months of follow-up.
Digital cities and the spread of COVID-19: Characterizing the impact of non-pharmaceutical interventions in five cities in Spain
Authors: Jorge P Rodríguez, Alberto Aleta, Yamir Moreno
Journal: Front Public Health (2023)
Keywords: covid-19, digital twins, epidemic spreading, non-pharmaceutical interventions, pandemic control
MeSH terms: COVID-19 / epidemiology, COVID-19 / prevention & control, Research Support, Non-U.S. Gov't, Cities, Humans, Models, Theoretical, SARS-CoV-2, Spain / epidemiology

Mathematical modeling has been fundamental to achieving near real-time accurate forecasts of the spread of COVID-19. Similarly, the design of non-pharmaceutical interventions has played a key role in the application of policies to contain the spread. However, there is less work done regarding quantitative approaches to characterize the impact of each intervention, which can greatly vary depending on the culture, region, and specific circumstances of the population under consideration. In this work, we develop a high-resolution, data-driven agent-based model of the spread of COVID-19 among the population in five Spanish cities. These populations synthesize multiple data sources that summarize the main interaction environments leading to potential contacts. We simulate the spreading of COVID-19 in these cities and study the effect of several non-pharmaceutical interventions. We illustrate the potential of our approach through a case study and derive the impact of the most relevant interventions through scenarios where they are suppressed. Our framework constitutes a first tool to simulate different intervention scenarios for decision-making.
Extra-uterine low grade endometrioid stromal sarcoma arising from ovarian endometriosis: a case report and review of the literature
Authors: Boubacar Efared, Ibrahim S Sidibé, Fatimazahra Erregad, Nawal Hammas, Laila Chbani, Hinde El Fatemi
Journal: Gynecol Oncol Res Pract (2019)
Keywords: endometrioid stromal sarcoma, endometriosis, ovary, uterus
MeSH terms: Case Reports

Background:
Endometrial stromal sarcoma (ESS) is a rare neoplasm accounting for only 0.2% of female genital tract tumors. The primary extra-uterine location of ESS is an extremely uncommon occurrence.
Case presentation:
We present a case of a 64-year-old woman presenting with abdominopelvic and bilateral ovarian tumors with misleading clinical presentation and diagnostic challenge. The histopathological examination of the resected specimens disclosed the diagnosis of primary extra-uterine ESS arising from ovarian endometriosis. Adjuvant therapy with an aromatase inhibitor drug was prescribed for the patient, and she is still alive with no evidence of disease 7 months after surgery.
Conclusion:
The awareness of the potential extra-uterine location of ESS should lead to correct diagnosis as this tumor has histopathological features and clinical behavior similar to its uterine counterpart.
Bevacizumab as a treatment option for choroidal neovascularisation due to large optic nerve drusen in a 14-year-old girl
Authors: Nils Alexander Steinhorst, Martin Spitzer, Christos Skevas
Journal: GMS Ophthalmol Cases (2020)
Keywords: bevacizumab, choroidal neovascularisation, cystoid edema, juvenile, optic disc drusen
MeSH terms: Case Reports

Purpose: To report the effects of a single intravitreous injection of bevacizumab for the treatment of secondary choroideal neovascularisation due to large optic disc drusen. Methods: A 14-year-old female patient with painless loss of vision in one eye presented with unusually large optic disc drusen and juxtapapillary choroidal neovascularisation with subretinal hemorrhage. She was treated with a single intravitreous injection of bevacizumab. Results: Visual acuity increased from 20/100 to 20/25 within 4 weeks after injection and remained at this level during the 12-month follow-up period. Conclusions: Bevacizumab is a possible primary treatment option for secondary choroidal neovascularisation due to large optic disc drusen in children as an alternative to other more invasive or complex procedures.
The impact of COVID-19 on the livelihoods of Kenyan slum dwellers and the need for an integrated policy approach
Authors: Daniel Solymári, Edward Kairu, Ráhel Czirják, István Tarrósy
Journal: PLoS One (2022)
MeSH terms: COVID-19 / epidemiology, Poverty Areas, Case Reports, Adolescent, Humans, Kenya / epidemiology, Policy, Urban Population

This paper aims to deal with the impact of COVID-19 on the livelihoods of disadvantaged persons living in slums in Kenya. Months after the first case of COVID-19 was reported in Kenya in March 2020, most of the studies that have been carried out pertaining to its impact on slum dwellers have concentrated on narrowly defined concerns e.g. the impact of COVID-19 on youth, gender based violence and nutrition. It is thus difficult to get a clear global picture of the overall impact of COVID-19 on the livelihoods of slum dwellers in Kenya. This paper relies on information gathered during a comprehensive qualitative micro study covering numerous aspects of slum dwellers' livelihoods, as well as information that has been produced by the Ministry of Health, civil society organizations that work in specific slums, private research organizations as well as local and foreign media houses. The slums whose information is reported in this paper were selected to be indicative of the over 300 slums that are located in Nairobi and Mombasa, the two most important cities in Kenya. The analysis concludes that slum dwellers were potentially at a higher risk under the pressures of COVID-19 of deteriorating conditions with regard to the provision of health services, employment, gender-based violence, education and youth-related problems, and human rights violations, and offers several recommendations to the government.
Risk of thyroid neoplasms in patients with 22q11.2 deletion and DiGeorge-like syndromes: an insight for follow-up
Authors: Walter Maria Sarli, Silvia Ricci, Lorenzo Lodi, Federica Cavone, Lucia Pacillo, Carmela Giancotta, Graziamaria Ubertini, Giampiero Baroncelli, Caterina Cancrini, Chiara Azzari, Stefano Stagi
Journal: Front Endocrinol (Lausanne) (2023)
Keywords: 22q11 deletion syndrome, digeorge, genetic syndrome, thyroid cancer, thyroid nodules
MeSH terms: DiGeorge Syndrome / complications, DiGeorge Syndrome / diagnosis, DiGeorge Syndrome / genetics, Thyroid Neoplasms / etiology, Thyroid Neoplasms / genetics, Case Reports, Multicenter Study, Follow-Up Studies, Humans, Neck

Introduction:
The chromosome 22q11.2 deletion syndrome comprises phenotypically similar diseases characterized by abnormal development of the third and fourth branchial arches, resulting in variable combinations of congenital heart defects, dysmorphisms, hypocalcemia, palatal dysfunction, developmental or neuropsychiatric disorders, and impairment of the immune system due to thymic dysfunction. Other genetic syndromes, often called DiGeorge-like, share clinical and immunological features with 22q11.2 deletion syndrome. This syndrome has been rarely associated with malignancies, mainly hematological but also hepatic, renal, and cerebral. Rarely, malignancies in the head and neck region have been described, although no aggregate of data on the development of thyroid neoplasms in patients with this clinical phenotype has been conducted so far.
Materials and methods:
To characterize this possible association, a multicenter survey was made. Thus, we present a case series of five pediatric patients with 22q11.2 deletion syndrome or DiGeorge-like syndrome who were occasionally found with confirmed or highly suspected neoplasms of the thyroid gland during their follow-up. In three cases, malignancies were histologically confirmed, but their outcome was good due to an early recognition of suspicious nodules and precocious surgery.
Conclusions:
This study underlines for clinicians the higher risk of neoplasms in the head and neck district for patients affected by these syndromes. It also emphasizes the importance of a prolonged clinical and ultrasound follow-up for patients with this clinical and immunological phenotype.
Case Report: Clinical Features of Childhood Leukoencephalopathy With Cerebral Calcifications and Cysts Due to SNORD118 Variants
Authors: Hong Jin, Xiaotun Ren, Husheng Wu, Yanqi Hou, Fang Fang
Journal: Front Neurol (2021)
Keywords: snord118, calcifications, child, cysts, leukoencephalopathy
MeSH terms: Case Reports

Background: Leukoencephalopathy with cerebral calcifications and cysts (LCC) is a rare autosomal recessive cerebral microangiopathy. Recently, biallelic variants in a non-protein-coding gene SNORD118 have been discovered to cause LCC. Case Presentation: We here report a genetically confirmed childhood case of LCC. The patient was a 4-year-and-1-month-old boy with focal seizures. The age at onset of his seizure was 10 days after birth. The seizures were well-controlled by antiepileptic treatment but reoccurred twice due to a head impact accident and a fever, respectively. He suffered from a self-limited esotropia and unsteady running gait during the seizure onset. He had the typical neuroimaging triad of multifocal intracranial calcifications, cysts, and leukoencephalopathy. Genetic analysis indicated that he carried compound heterozygous variants of n.*9C>T and n.3C>T in SNORD118, which were inherited from his parents. Conclusion: We report a childhood LCC case with compound heterozygous variants in SNORD118. To the best of our knowledge, the patient reported in our case had the youngest onset age of LCC with a determined genotype. The triad cerebral-imaging findings of calcifications, cysts, and leukoencephalopathy provide a crucial diagnostic basis. Moreover, the gene assessment, together with the clinical investigations, should be considered for the diagnosis of LCC.
Atypical Histiocyte-Rich Sweet's Syndrome
Authors: Sharon Chi, Marcia Leung, Mark Carmichael, Michael Royer, Sunghun Cho
Journal: Case Rep Dermatol Med (2017)
MeSH terms: Case Reports

Sweet's Syndrome is a rare neutrophilic dermatosis thought to be a result of immune dysregulation occurring in the setting of drug exposure, recent infection, pregnancy, and underlying malignancy or idiopathic with specific and widely accepted diagnostic criteria established in the literature. Other organ systems can be involved with varying degrees of severity. An unusual case of Sweet's Syndrome associated with myopericarditis, acral involvement, and atypical histological findings with predominance of histiocytes is described here.
Response of Human Immunodeficiency Virus-Associated Cerebral Angiitis to the Combined Antiretroviral Therapy
Authors: Julian Cheron, Chloé Wyndham-Thomas, Niloufar Sadeghi, Gilles Naeije
Journal: Front Neurol (2017)
Keywords: hiv-associated angiitis, brain vasculitis, cerebral angiitis, human immunodeficiency virus, vessel wall imaging
MeSH terms: Case Reports

When secondary causes are excluded, mechanisms underlying central nervous system angiitis (ACNS) in human immunodeficiency virus (HIV)-infected patients are still not understood and optimal treatment remains undefined. We report here a patient with an untreated HIV infection who presented multiple ischemic strokes probably due to HIV-ACNS. ACNS signs on vessel-wall imaging magnetic resonance monitoring retracted with combined antiretroviral therapy without adjunct immunosuppressive drugs.
A Successful Esthetic Approach of Gingival Depigmentation Using Microneedling Technique and Ascorbic Acid (Vitamin C)
Authors: Diana Mostafa, Shaden M Alotaibi
Journal: Case Rep Dent (2022)
MeSH terms: Case Reports

A gingival depigmentation is a periodontal plastic procedure that is performed in order to remove melanocytic pigmentation. A variety of different modalities have been proposed for removing hyperpigmentation involving surgical scraping, gingival autograft, cryotherapy, electrosurgery, and lasers. However, the microneedling technique is a nonsurgical procedure that creates microholes to facilitate the penetration of topical medications across the connective tissues. Case Description. A healthy female patient aged 25 years with a pigmented gingiva seeking gingival depigmentation. On examination, a dark brown ribbon of hyperpigmentation was observed within the mandibular attached gingiva. The case was diagnosed as physiological moderate gingival pigmentation (pigmentation index score = 3). The patient was interested in achieving aesthetic results with minimally invasive, nonexpensive procedures. Based on the patient's concerns, the microneedling technique using vitamin C was suggested and consented. We used a dermapen device to microneedle the gingiva until bleeding pinpoints were observed; then, topical ascorbic acid was applied. After 3 days, our outcomes revealed an excellent aesthetic pink gingival appearance. Conclusions and Practical Implications. Compared to other minimally invasive techniques, our technique is less expensive and more risk-free. Our novel technique of using dermapen and topical ascorbic acid has shown promising results to our case which gives new perspectives for its application in gingival depigmentation.
Case Report: Prenatal and Postnatal Management for Fetal Bronchogenic Cysts During the COVID-19 Pandemic
Authors: Lin Cheng, Jie Duan, Mei Wang, Dan Lu, Huan Li, Jianhong Ma, Juan Liu, Cheng Wang, Yuanzhen Zhang
Journal: Front Pediatr (2021)
Keywords: covid-19 pandemic, mri, bronchogenic cyst, multidisciplinary approaches, prenatal and postnatal management
MeSH terms: Case Reports

Background: A fetal bronchogenic cyst (BC) is a rare congenital anomaly with an incidence of 0.147-0.238‰. The coronavirus disease 2019 (COVID-19) pandemic, as a particular situation, hindered pregnant women from receiving periodic prenatal checkups. Case Description: Until 34+6 weeks of gestation, a fetal case of the intrathoracic cyst was found by ultrasound examination. Further, MRI examination confirmed the diagnosis of the congenital mediastinal cystic lesion, probably a BC. Genetic testing was not conducted due to the COVID-19 pandemic. At 38+5 weeks of gestation with maternal COVID-19 testing negative, a live girl was delivered by cesarean section. Five months later, the child underwent bronchocystectomy, and the postoperative pathological lesions confirmed a (right upper mediastinum) BC. Conclusion: Herein, we reported the prenatal and postnatal management for a rare case of the congenital BC by multidisciplinary approaches during the COVID-19 pandemic. Fetal MRI and screening for fetal chromosomal abnormalities are especially recommended. This case contributes to the awareness that the COVID-19 pandemic interferes with regular follow-up schedules during pregnancy and may interfere with timely performed additional tests; which leads to more accurate genetic counseling. A combination of multidisciplinary approaches, including radiology, infection control, genetic counseling, obstetrics, and pediatric surgery, is pivotal for managing fetal BC during the COVID-19 pandemic.
Management of Buccal Screw Access Hole Positioning for Implant Fixed Complete Dentures: A Report of Two Patients and a Proposed Decision Tree
Authors: Fawaz Alzoubi
Journal: Case Rep Dent (2021)
MeSH terms: Case Reports

The present report demonstrated the use of two methods to correct the positioning of buccal screw access holes in both implant- and abutment-level implant-supported fixed complete dentures in two patients. The report suggests that nonaxially tightened abutments (in this report, dynamic abutments), angled multi-unit abutments, and the use of a milled framework with individual crowns aid in masking buccal screw access holes while maintaining the benefits of a screw-retained design. A decision tree is also proposed to facilitate the workflow when faced with such clinical scenarios.
Dynamic FDG PET/CT on bladder paraganglioma: A case report
Authors: Makoto Taninokuchi Tomassoni, Arrigo Cattabriga, Caterina Gaudiano, Federica Ciccarese, Beniamino Corcioni, Lorenzo Bianchi, Riccardo Schiavina, Eugenio Brunocilla, Rita Golfieri
Journal: Front Med (Lausanne) (2022)
Keywords: fdg pet/ct, bladder cancer, bladder paraganglioma, nuclear medicine, radiology
MeSH terms: Case Reports

Paraganglioma (PGL) is characterized by equivocal clinical manifestations and arriving to a suspicion might be challenging. Nevertheless, diagnostic imaging and nuclear medicine are a fundamental part of the diagnosis and management of this particular neuroendocrine tumor (NET). We herein report a rare case of bladder paraganglioma with unusual onset and typical PET/CT characteristics that led to its recognition.