OpenMed/multicare-articles huggingface dataset:
Economic migration and the socio-economic impacts on the emigrant's family: A case of Ward 8, Gweru Rural district, Zimbabwe
Authors: Everson Ndlovu, Richard Tigere
Journal: Jamba (2018)

Gweru Rural district in the Midlands province of Zimbabwe has witnessed an increasing number of outward migrations of breadwinners, leaving behind a desperate environment for families. This study was motivated by the realisation that most of the sick left behind, the elderly and children would visit the health centres unaccompanied, risking taking prescribed drugs incorrectly, thus further compromising their health. The study sought to establish the socio-economic effects of international migration on family members left behind in ward 8 of Gweru Rural. The study adopted a qualitative case study approach. Focus group discussions, questionnaires and structured individual interviews were used to elicit for data. Non-probability sampling design was used because of small samples available. Convenience and purposive sampling techniques were particularly used. Data were manually analysed and presented both qualitatively and quantitatively. The study revealed that international migration particularly to South Africa, especially by non- professionals, was not yielding the much expected economic gains; instead it was characterised by more negative social effects on the emigrant's family. The study recommends that emigrants should consider migrating with their loved ones and, where it is not feasible, to put in place sound alternative caregiving arrangements. The study has provided an insight into international migration and its effects on left-behind families. However, a more comprehensive and quantitative survey remains critical to delving deeper into this migration phenomenon, particularly on how both the emigrant and left-behind spouses handle the issue of conjugal rights.
Tuberculous Spondylitis: A Report of Different Clinical Scenarios and Literature Update
Authors: Catarina Lacerda, Rita Linhas, Raquel Duarte
Journal: Case Rep Med (2017)
MeSH terms: Case Reports

Tuberculosis is still one of the most important health problems in the world. In developed countries, the proportion of extrapulmonary tuberculosis cases is increasing. Nowadays tuberculous spondylitis, also known as Pott disease, is a rare clinical condition but can cause severe vertebral and neurological sequelae that can be prevented with an early correct diagnosis. The aim of this paper is to increase awareness of tuberculous spondylitis in modern times, describing three different cases and discussing its best diagnostic and therapeutic approach based on the current literature.
Bilateral Pulmonary Embolism after a Short-Haul Flight in a Man with Multiple Risk Factors including Sickle Cell Trait
Authors: Kamille Abdool, Kanterpersad Ramcharan, Antonio J Reyes, Nadiene Lutchman, Adrian Alexander
Journal: Case Rep Emerg Med (2017)
MeSH terms: Case Reports

We report a case of pulmonary embolism (PE) in an Afro-Caribbean man following a short commercial flight of less than 5,000 kilometers (Km) in economy class with a 1-month interval between journeys. He had an elevated body mass index (BMI) and sickle cell trait (SCT) with hyperhomocysteinemia. No other preexisting source of venous thrombosis was found. We posit that venous thromboembolism (VTE) and/or PE may have been a complication of SCT in an individual with other multiple risk factors. We discuss the possible interaction of these risk factors for VTE and/or PE and the implications for travelers at risk. The need for a PE risk score and guidelines for the prophylaxis of thromboembolism among travelers exists.
Esthetic Rehabilitation of Primary Anterior Teeth using Temporization Material: A Novel Approach
Authors: Neeraj Gugnani, I K Pandit, Monika Gupta, Jyoti Nagpal
Journal: Int J Clin Pediatr Dent (2017)
Keywords: early childhood caries, esthetic rehabilitation, primary tooth trauma, strip crown, temporization material
MeSH terms: Case Reports

Pediatric dentists should always aim for esthetic and functional rehabilitation of decayed/traumatized primary teeth. The most common method for restoring such teeth involves the use of "strip crowns" with composites, while the recent trend is toward using other extracoronal restorations including preve-neered stainless steel crowns and zirconia crowns. All these restorative options have shown good success rates, but also have some limitations. This case series depicts novel clinical technique of using a temporization material for full-coronal restoration(s) in primary anterior teeth. This included the chair-side custom fabrication of full-coronal restoration using temporization material, which has resulted in good immediate esthetics and might be a cost-effective alternative for restoring primary anterior teeth in future.
How to cite this article:
Gugnani N, Pandit IK, Gupta M, Nagpal J. Esthetic Rehabilitation of Primary Anterior Teeth using Temporization Material: A Novel Approach. Int J Clin Pediatr Dent 2017;10(1):111-114.
Association between a Primitive Brain Tumor and Cerebral Aspergillosis
Authors: Siegfried Hélage, Charles Duyckaerts, Danielle Seilhean, Jean-Jacques Hauw, Jacques Chiras
Journal: Case Rep Med (2012)
MeSH terms: Case Reports

Cerebral aspergillosis is a rare pathology of poor prognosis in spite of the use of adapted antifungal treatments. This infection of the central nervous system is generally the complication of an invasive aspergillosis with hematogenic scattering from pulmonary focal spots. It can arise in immunocompetent patients treated with prolonged corticotherapy or chemoradiotherapy for cancer. A case of lethal cerebral aspergillosis in a patient with an infiltrative glioma treated with corticotherapy and radiotherapy is reported. Clinicopathological aspects and therapeutic approach are described.
Plasma Cell Gingivitis Treated with Photobiomodulation, with No Recurrence for a Five-Year Follow-Up
Authors: Federica Pulicari, Matteo Pellegrini, Maurizio Pascadopoli, Massimo Porrini, Elisabetta Kuhn, Andrea Scribante, Francesco Spadari
Journal: Case Rep Dent (2022)
MeSH terms: Case Reports

Introduction:
Plasma cell gingivitis (PCG) is a chronic inflammatory disease usually affecting the vestibular portion of the gingival mucosa. Clinical presentation is marked by erythematous macules of intense red color, confluent, and delimited from the healthy neighboring mucosa. Generally asymptomatic, the gum lesions sometimes are accompanied by burning sensations and a sense of local tension. Recommended treatment is the use of topical steroids, but with apparent initial healing that is not stable over time. The present case report concerns a patient diagnosed with PCG in November 2017, with a five-year follow-up. This is the first patient with PCG successfully treated with non-surgical periodontal therapies associated with photobiomodulation (PBM).
Methods:
A 64-year-old male patient had intense erythema and edema on the vestibular side of the gingival mucosa area from 1.5 to 2.5. The patient's symptomatic subjectivity parameters were evaluated through dedicated questionnaires. Erythema and gingival bleeding were also evaluated. Periodontal charting was not pathological, but intense bleeding was noted. Multiple biopsies were performed, and microscopic findings confirmed the clinical hypothesis of PCG.
Results:
The treatment applied was PBM associated with periodontal therapy. The patient demonstrated a progressive improvement in clinical parameters considered and reported symptoms. During the five-year follow-up, no recurrence of the disease was observed.
Conclusions:
The combined PBM and periodontal therapies have proved to be sufficiently effective in the control of PCG, showing reduction of the intense inflammatory, erythematous component, and gingival bleeding, and are a valid treatment alternative to topical steroids.
Integrating electrodermal biofeedback into pharmacologic treatment of grand mal seizures
Authors: Tullio Scrimali, Damiana Tomasello, Massimo Sciuto
Journal: Front Hum Neurosci (2015)
Keywords: biofeedback, electrodermal activity, epilepsy, grand-mal seizures, sympathetic arousal

Electrodermal activity (EDA) and electrodermal biofeedback, when integrated with pharmacologic treatments, indicate promising methods for the treatment of grand mal seizures. They can be used to monitor patient arousal and help patients learn new strategies to better cope with stress and anxiety. Our proposed method can possibly reduce the number of crises for patients who are dependent on pharmacologic therapy and can improve their quality of life. This article describes the scientific background of electrodermal monitoring and electrodermal biofeedback for patients affected by grand mal seizures. In this study, we have reported a clinical case study. The patient was treated for 2 years with electrodermal biofeedback to augment pharmacologic treatments. The trial has been designed in accordance with "n = 1 case study research". Our results have shown that our methods could achieve a significant reduction in grand mal seizures and sympathetic arousal when applied. The patient under consideration was also relaxed and exhibited greater competency to cope with stress. Additionally, the patient's sense of mastery and self-efficacy was enhanced.
A novel BCR-ABL1 mutation in a patient with Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia
Authors: Raquel Vinhas, Alexandra Lourenço, Susana Santos, Marcos Lemos, Patrícia Ribeiro, Aida Botelho de Sousa, Pedro Viana Baptista, Alexandra Ramos Fernandes
Journal: Onco Targets Ther (2018)
Keywords: all, philadelphia chromosome, e14a2, mutation, py440c
MeSH terms: Case Reports

Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) represents the most common genetic subtype of adult ALL (20%-30%) and accounts for approximately 50% of all cases in the elderly. It has been considered the subgroup of ALL with the worst outcome. The introduction of tyrosine kinase inhibitors (TKIs) allows complete hematologic remission virtually in all patients, with improved disease-free survival and overall survival. Nevertheless, the emergence of resistant mutations in BCR-ABL1 may require different TKI strategies to overcome the patient's resistance and disease relapse. Here, we report a Ph+B-ALL case with persistent minimal residual disease (MRD) after treatment with dasatinib. The patient expressed the P190BCR-ABL1 isoform and a novel BCR-ABL1 mutation, p.Y440C. The latter is in the C-terminal lobe of the kinase domain, which likely induces deviations in the protein structure and activity and destabilizes its inactive conformation. The treatment was substituted by bosutinib, which binds to the active conformation of the protein, prior to allogeneic bone marrow transplant to overcome the lack of a complete response to dasatinib. These findings strengthen the importance of BCR-ABL1 mutational screening in Ph+ patients, particularly for those who do not achieve complete molecular remission.
Restoring Teeth with an Advanced Lithium Disilicate Ceramic: A Case Report and 1-Year Follow-Up
Authors: Felicitas Hölken, Helmut Dietrich
Journal: Case Rep Dent (2022)
MeSH terms: Case Reports

Advancements in materials science and bonding protocols as well as new manufacturing methods foster the development of novel ceramic materials to meet the increased demands for highly aesthetic, biocompatible, and long-lasting restorations in fixed prosthodontics. This case report highlights the minimally invasive rehabilitation with a new advanced lithium disilicate (ALD) ceramic block. It is reinforced with virgilite crystals in managing esthetic demand of patient besides having a high flexural strength. According to the manufacturer, the material provides a biaxial strength measured at >700 MPa and improved optical properties. The remarkable speed sintering time of approx. 4.5 minutes makes processing very fast. Time efficiency, predictability, and economically interesting treatment options are of great importance in current dentistry and can be well implemented in CAD/CAM dentistry. The newly introduced ALD ceramic for the "Chairside Economical Restoration of Esthetic Ceramics"/"CEramic REConstruction" (CEREC) system produces an esthetically pleasing and clinically excellent restoration. The shorter processing time combined with high flexural strength will optimize the chairside workflow. New treatment indication options for lithium disilicate ceramics will expand. Although more evidence from long-term clinical studies is needed to verify the clinical performance and manufacturer recommendations regarding indication, preparation and cementation must be followed very strictly. In the present case report, restorations were indicated for seven posterior teeth, which were prepared, scanned, designed with CEREC-Primescan SW 5.1.3, and fabricated with MCX5. The monolithic restorations were placed adhesively. The rehabilitation with the ALD blocks resulted in an aesthetically pleasing, functional outcome that improved overall treatment time and increased patient and practitioner satisfaction, which remained stable over a one-year follow-up period.
Case report: Pulmonary hypertensive crisis leading to cardiac arrest during endoscopic evaluation in a 6-year-old boy with autism, severe malnutrition, and undiagnosed scurvy
Authors: Laura A Quinn, Stephanie P Gilley, Allison D Ta, Benjamin S Frank, Carolyn B Foley, Jaime M Moore
Journal: Front Pediatr (2022)
Keywords: arfid, autism, malnutrition, micronutrient deficiencies, pulmonary hypertension (pah), risk stratifcation, scurvy, vitamin c deficiency
MeSH terms: Case Reports

Pediatric gastroenterologists are often responsible for the evaluation of malnutrition in the setting of selective eating. Endoscopic evaluation for conditions including eosinophilic esophagitis and celiac disease can help to identify and treat mucosal disease contributing to food selectivity. However, undiagnosed micronutrient deficiencies can cause cardiovascular derangements that significantly increase a patient's anesthetic risk. Vitamin C deficiency in particular, alone or in combination with severe malnutrition, is associated with a severe but reversible form of pulmonary arterial hypertension that, while life threatening in the acute phase, may significantly improve within days of starting ascorbic acid replacement therapy. Here we present a case of a 6-year-old boy with autism spectrum disorder (ASD), severe malnutrition, and undiagnosed chronic vitamin C deficiency who developed a pulmonary hypertensive crisis after induction of general anesthesia leading to cardiac arrest during endoscopic evaluation. While the association between food selectivity among youth with neurodevelopmental differences and vitamin C deficiency is well-described, and pulmonary hypertension is a recognized rare complication of scurvy, extant literature has not addressed next steps to improve patient outcomes. Using this case report as a foundation, we discuss specific patient populations to screen and treat for micronutrient deficiencies prior to anesthesia and propose a novel clinical algorithm for pre-anesthesia risk stratification and mitigation in patients specifically at risk for scurvy and associated pulmonary hypertension.
Case Report: Pancreatic metastasis of renal cell carcinoma 16 years after nephrectomy
Authors: Yidan Lou, Kaibo Guo, Song Zheng
Journal: Front Oncol (2023)
Keywords: kdm5c, pten, vhl, genetics, isolated pancreatic metastasis, late recurrence, renal cell carcinoma (rcc)
MeSH terms: Case Reports

Background:
Renal cell carcinoma (RCC) is the most common renal malignancy, and may metastasize to different sites in the body via hematogenous and lymphomatous routes. The pancreas is a rare metastatic site of metastatic RCC (mRCC) and isolated pancreatic metastasis of RCC (isPMRCC) is even rarer.
Results:
The present report describes a case of isPMRCC that recurred 16 years after surgery. The patient responded well to the treatment with pancreaticoduodenectomy and systemic therapy, and no recurrence was recorded after 2 years.
Conclusions:
isPMRCC is a distinct subgroup of RCC with unique clinical characteristics that may be explained by its underlying molecular mechanisms. Surgery and systemic therapy confer survival benefits to patients with isPMRCCs, although the recurrence problem has to be paid attention to.
A Case of Panic Attacks Developing After 10 Years of Chronic Cannabis Use in a Patient With No Prior Psychiatric History
Authors: Grace A Johnson, Lucy Guerra, Asa Oxner
Journal: Cureus (2023)
Keywords: agoraphobia, cannabis (marijuana), cannabis use disorder, drug addiction, generalised anxiety disorder, heart palpitations, marijuana abuse, panic disorders
MeSH terms: Case Reports

Cannabis use for medical and recreational purposes is increasing. Inhibitory activity of cannabinoids (CB) at the CB1 and CB2 receptors centrally and peripherally mediate the therapeutic effects that are wielded for palliation of pain, anxiety, inflammation, and nausea in indicated conditions. Cannabis dependence is also associated with anxiety; however, the direction of causality is unknown, such as whether anxiety disorders lead to cannabis use, or whether cannabis contributes to the development of anxiety disorder. The evidence hints that both may have validity. Here we present a case of cannabis-associated panic attacks following 10 years of chronic cannabis dependence in an individual with no prior psychiatric history. The patient is a 32-year-old male with no significant past medical history who presented complaining of five-minute episodes of palpitations, dyspnea, upper extremity paresthesia, subjective tachycardia, and cold diaphoresis occurring in a variety of circumstances for the past two years. His social history was significant for 10 years of smoking marijuana multiple times daily, which he had quit over two years ago. The patient denied past psychiatric history or known anxiety problems. Symptoms were unrelated to activity and only relieved with deep breathing. The episodes were not associated with chest pain, syncope, headache, or emotional triggers. The patient had no family history of cardiac disease or sudden death. The episodes were refractory to the elimination of caffeine, alcohol, or other sugary beverages. The patient had already stopped smoking marijuana when the episodes began. Due to the unpredictable nature of the episodes, the patient reported a growing fear of being in public. On laboratory workup, metabolic and blood panels were within normal limits, as well as thyroid studies. Electrocardiogram showed normal sinus rhythm, and continuous cardiac monitoring revealed no arrhythmias or abnormalities despite the patient indicating multiple triggered events within the duration of monitoring. Echocardiography also showed no abnormalities. With organic cardiac causes of the subjective palpitation episodes ruled out, a psychogenic etiology of the episodes was presumed, and the patient was referred to behavioral health services. In conclusion, cannabis-induced anxiety or panic disorders should be considered in patients with no prior psychiatric history presenting with anxiety-like attacks following a period of cannabis dependence or current use. These patients should be advised to cease cannabis use and referred to behavioral medicine.
Dabrafenib and Trametinib in BRAF Mutant Metastatic Conjunctival Melanoma
Authors: Ernesto Rossi, Brigida Anna Maiorano, Monica Maria Pagliara, Maria Grazia Sammarco, Tommaso Dosa, Maurizio Martini, Guido Rindi, Emilio Bria, Maria Antonietta Blasi, Giampaolo Tortora, Giovanni Schinzari
Journal: Front Oncol (2019)
Keywords: braf, mek, conjunctival, melanoma, target therapy
MeSH terms: Case Reports

Conjunctival melanoma is a rare primary ocular tumor. So far, no standard treatment exists for metastatic disease. Similarly to cutaneous melanoma, up to 50% of conjunctival melanomas harbor BRAF mutations. The most common is represented by V600E. Combined therapy with BRAF and MEK inhibitors is approved for BRAF mutant cutaneous metastatic melanomas. Herein, we report a case of a 70-years old patient with a metastatic conjunctival melanoma harboring V600E BRAF mutation successfully treated with dabrafenib and trametinib.
Case Report: A Rare Orbital Abscess Caused by Dacryocystitis After Administration of Rebamipide Ophthalmic Suspension
Authors: Hitoshi Imamura, Hiroshi Eguchi, Masuo Sakamoto, Fumika Hotta, Hitoshi Tabuchi, Shunji Kusaka
Journal: Front Med (Lausanne) (2021)
Keywords: calcium phosphate, case report, dacryocystitis, lacrimal sac concretion, orbital abscess, rebamipide ophthalmic suspension
MeSH terms: Case Reports

Background: Rebamipide ophthalmic suspension was launched in Japan in 2012 and is used for the treatment of dry eye. Case Presentation: We report two cases of orbital abscess, which resulted from dacryocystitis that occurred after administration of rebamipide ophthalmic suspension. Computed tomography images showed an eyeball deformity in one case and exophthalmos in the other. In both cases, light microscopy, scanning electron microscopy and energy dispersive X-ray examinations revealed lacrimal sac concretions, which contained calcium phosphate crystals that were surrounded by microorganisms. Lacrimal sac concretion removal from the lacrimal sacs during dacryocystorhinostomies was performed on both patients. Although the postoperative outcome was favorable in one case, vision was lost in the other case due to the development of retinal artery occlusion as a complication of the orbital abscess, despite lacrimal sac concretion removal and administration of antimicrobials. Conclusions: This is the first case report to highlight that rebamipide ophthalmic suspension can cause an orbital abscess via development of lacrimal sac concretion. Ophthalmologists should be aware that rebamipide ophthalmic suspension might induce the formation of concretion in the lacrimal sac.
A Corticobasal Syndrome Variant of Familial Creutzfeldt-Jakob Disease with Stroke-Like Onset
Authors: Ján Necpál, Martin Stelzer, Silvia Koščová, Michal Patarák
Journal: Case Rep Neurol Med (2016)

Creutzfeldt-Jakob disease (CJD) is an untreatable rare human prion disease characterized by rapidly progressive dementia along with various neurological features, including myoclonus and sometimes other movement disorders. The clinical course is typically insidious and rapid, leading to an early death. In general, the most common form is sporadic CJD; however, Slovakia is typical for a high percentage of genetic cases. We present an unusual case report of a 65-year-old man with a sudden, stroke-like onset of motor aphasia with right-sided levodopa unresponsive parkinsonism, alien hand, and other characteristic features of corticobasal syndrome (CBS), with rapid deterioration and death on the 32nd day of the disease. Various neurodegenerative disorders are manifested with CBS as a clinical phenotype, including corticobasal degeneration (CBD), progressive supranuclear palsy, Alzheimer's disease, and CJD. In our patient, mutation E200K and M129M polymorphism of the PRNP gene and typical immunohistochemical findings pointed to a diagnosis of CJD. The patient's mother died of CJD many years ago. Several CBS-CJD cases were described, but the atypical stroke-like onset of CBS-CJD, an extremely rare presentation of CJD, makes our case unique worldwide.
Heat Stroke Leading to a Fatal Outcome
Authors: Som N Chalise, Ehsun Mirza, Raza Malik
Journal: Cureus (2023)
Keywords: acute encephalopathy, acute kidney injury, acute liver failure, disseminated intravascular coagulation (dic), heat stroke, multi-organ failure
MeSH terms: Case Reports

Heat stroke (HS) can cause several physiological changes in the body. In its most severe form, it can cause multi-organ failure including encephalopathy, circulatory shock, liver failure, renal failure, disseminated intravascular coagulation, and rhabdomyolysis among others. HS is a preventable condition; however, it can be life-threatening in severe forms. We present a case of HS in a 54-year-old male, with rapidly progressive multi-organ failure and a fatal outcome along with a brief literature review.