OpenMed/multicare-articles huggingface dataset:
A Diabetic Patient Complicated With Pancreatic Cancer After Using Liraglutide: A Case Report
Authors: Shengjie Wu, Jiabing Wang, Li Jing, Liping Chen
Journal: Front Endocrinol (Lausanne) (2021)
Keywords: diabetes mellitus, glucagon-like peptide-1 (glp-1), glucose-dependent insulinotrophic polypeptide (gip), liraglutide, pancreatic cancer
MeSH terms: Carcinoma, Pancreatic Ductal / chemically induced, Carcinoma, Pancreatic Ductal / complications, Diabetes Mellitus, Type 2 / complications, Hypoglycemic Agents / adverse effects, Liraglutide / adverse effects, Pancreatic Neoplasms / chemically induced, Pancreatic Neoplasms / complications, Case Reports, Research Support, Non-U.S. Gov't, Aged, Biopsy, Carcinoma, Pancreatic Ductal / diagnostic imaging, Humans, Hypoglycemic Agents / therapeutic use, Liraglutide / therapeutic use, Lymphatic Metastasis, Male, Pancreas / diagnostic imaging, Pancreas / pathology, Pancreatic Neoplasms / diagnostic imaging, Tomography, X-Ray Computed, Hypoglycemic Agents, Liraglutide

Background:
Diabetes and cancer are both multifactorial diseases, and epidemiologic evidence indicates that diabetes may be associated with the incidence of certain types of cancer. In diabetes the risk of pancreatic cancer is increased significantly. However, whether certain diabetes treatment being related with the risk of pancreatic cancer remains unclear. In this report, we presented a case of pancreatic ductal adenocarcinoma in a diabetic patient in China after being treated with liraglutide, a novel glucagon-like peptide-1 (GLP-1) analog.
Case report:
A 71-year-old Han Chinese man who had had a type 2 diabetes for 25 years presented at the endocrinology department with discomfort in the left upper quadrant of abdomen for 10 days. The patient's vital signs and laboratory findings were unremarkable except for the elevated level of carbohydrate antigen (CA19-9). The upper abdomen routine enhanced computed tomography (CT) scan showed low density of the pancreatic body and tail, and the histopathological result of the pancreatic biopsy samples was pancreatic ductal adenocarcinoma with regional lymph node metastasis. We reviewed his former medical records and found that liraglutide was added to his hypoglycemic treatment regimen 20 months ago. At that time, the level of tumor biomarkers and upper abdomen routine CT were unremarkable. We estimated the causality between liraglutide and pancreatic cancer by the Naranjo Adverse Drug Reaction Probability scale and WHO-Uppsala Monitoring Centre (WHO-UMC) system, and the causality turned out to be possible.
Conclusion:
Our report suggests that liraglutide may be related with the genesis and development of pancreatic cancer and also highlights the importance of regular checkups in diabetic patients treated with liraglutide. However, our report has some notable limitations, and further longer-term follow-up trials with larger sample should be conducted in future to assess the causality between liraglutide and pancreatic cancer.
Spontaneous vertebral artery dissection in an elder patient: a case report
Authors: Fatima-Ezzahrae Badi, Mouna Sabiri, Samia El Manjra, Samira Lezar, Fatiha Essodegui
Journal: Pan Afr Med J (2021)
Keywords: vertebrobasilar artery dissection, atherosclerosis, case report, stroke
MeSH terms: Stroke, Vertebral Artery Dissection / diagnostic imaging, Case Reports, Aged, Humans, Magnetic Resonance Imaging, Risk Factors

Vertebrobasilar artery dissection (VBD) is a rare cause of posterior ischemic strokes. It is more likely to occur in young patients with a history of traumatism or hereditary connective tissue disorders. Spontaneous VBD is rare, especially in elder patients. This paper aims to report the case of an old patient that presented with a posterior ischemic stroke due to a spontaneous vertebral artery dissection (SVAD), linked to atherosclerosis. The diagnosis of SVAD was made by Magnetic resonance imaging (MRI) which is the gold standard technique to diagnose this pathology in a short time so the patient could receive adequate treatment.
Reconstruction of severe burn contractures of the upper lip in males using a pedicled superficial temporal artery hair-bearing flap. Two case reports
Authors: Mohammad M Al-Qattan, Musa H AlMutairi
Journal: Int J Surg Case Rep (2020)
Keywords: burn contracture, males, pedicled superficial temporal artery hair-bearing flap, reconstruction, upper lip
MeSH terms: Case Reports

Introduction:
Severe burn contractures of the upper lip are usually treated either with full thickness skin grafts or flaps. Most authors recommend the free radial forearm flap as the flap of choice. In males, another free flap option is the use of the superficial temporal artery hair-bearing free flap.
Case reports:
In this report, we demonstrate that the superficial temporal artery hair-bearing flap may be used as a pedicle flap (rather than a free flap) for the reconstruction of severe upper lip burn contractures in males. We show our method of flap delay and design to ensure that the distal part of the flap will survive; and this will be demonstrated in two case reports.
Discussion:
The pedicled superficial temporal artery flap is much simpler to execute than free flaps.
Conclusions:
Severe post burn contractures of the upper lip in males may be reconstructed using the pedicled superficial temporal artery hair-bearing flap. In order for the flap to reach the contralateral side of the lip, it will have to cross the midline in the scalp. We demonstrate our method of flap delay and design to ensure flap safety and viability. We also show that concurrent burn deformities in close proximity of the upper lip should be treated prior to upper lip reconstruction. Finally, we stress on the principle of reconstructing the entire skin of the upper lip as one aesthetic unit.
Rare Course of Bilateral Congenital Diaphragmatic Hernia Treated Thoracoscopically-Case Report
Authors: Krystian Toczewski, Sylwester Gerus, Mateusz Palczewski, Dariusz Patkowski
Journal: Front Pediatr (2020)
Keywords: simpson-golabi-behmel syndrome, bilateral congenital diaphragmatic hernia, case report, newborn, thoracoscopy
MeSH terms: Case Reports

We present a rare case of metachronous bilateral congenital diaphragmatic hernia (CDH) in a newborn with additional malformations: macroglossia, pectus excavatum, and confirmed Simpson-Golabi-Behmel syndrome. We performed a successful thoracoscopic subsequent repair with a patch of the bilateral type C CDH. Despite using insufflation that should cause bilateral pneumothorax at first procedure there was no clinical signs of such a one. Contralateral CDH diagnosis was possible only on the basis of the symptoms that occurred after the first operation. After 13 months the patient is without recurrence. In selected patients, staged thoracoscopy may be a safe and feasible method of bilateral CDH treatment.
Effect of Adalimumab on Refractory Arthritis in Juvenile Idiopathic Inflammatory Myopathy with Anti-MDA5 Autoantibody
Authors: Takako Miyamae, Takuma Hara, Aki Hanaya, Yumi Tani, Takayuki Kishi, Hisashi Yamanaka
Journal: Case Rep Rheumatol (2018)
MeSH terms: Case Reports

A 10-year-old girl manifested persistent fever, skin rash, leg pain, fatigue, and joint pain. Based on muscle weakness, elevated muscle-derived enzymes, magnetic resonance imaging, and skin biopsy results, the diagnosis was juvenile idiopathic inflammatory myopathies (JIIM). Chest CT was normal; the anti-melanoma differentiation-associated protein-5 (anti-MDA5) autoantibody was positive. Initial manifestations subsided after prednisolone (PSL) and methotrexate treatment. After the PSL dosage was decreased, the patient presented with metacarpophalangeal (MCP) joint pain and swelling in both index fingers, synovial fluid, and signals on power Doppler ultrasound. The arthritis was refractory to cyclosporine and tacrolimus. Radiography showed progressive MCP joint space narrowing and joint erosion. Adalimumab was initiated 14 months after disease onset. There was a mildly increased matrix metalloproteinase-3 (MMP3) level, an erythrocyte sedimentation ratio (ESR), and a normal CRP level. Adalimumab resulted in decreased MCP joint pain and swelling. PSL was discontinued 10 months after adalimumab initiation; after 9 more months of adalimumab, there were no significant ultrasonography findings. MMP3 and ESR levels normalized during treatment. Radiography after 2 years of adalimumab showed further progressive MCP joint space narrowing restricting dorsiflexion. This report clarified that anti-MDA5-positive JIIM joint manifestations were due to active synovitis and that adalimumab is required for severe cases. Further experience is needed to determine the pathology, severity, and prognosis of this type of arthritis.
Colon penetration by a femoral prosthesis: a case report
Authors: Reinhard Dolp, Doris Henne-Bruns
Journal: GMS Interdiscip Plast Reconstr Surg DGPW (2017)
Keywords: colon penetration, colon perforation
MeSH terms: Case Reports

We report of a 57-year-old female patient who underwent a hemipelvectomy with a hemipelvic replacement in 1992. In 2013 the implanted material had to be partially removed due to a periprothetic infection. At that time a palacos spacer was implanted which penetrated two years later into the colon cavity.
Case report: Immune remission from generalized myasthenia gravis in a dog with a thymoma and cholangiocellular carcinoma
Authors: Thomas Mignan, Robert White, Kimberley Stee, Giuseppe Bonanno, Mike Targett, Mark Lowrie
Journal: Front Vet Sci (2023)
Keywords: acetylcholine, acquired, canine, junctionopathy, thymectomy
MeSH terms: Case Reports

A 9-year-old male neutered Cockapoo was presented with an acute and progressive history of exercise induced weakness involving all limbs, and bilateral decreased ability to blink. Investigations revealed generalized myasthenia gravis alongside the presence of a thymoma and a cholangiocellular carcinoma. Symptomatic treatment through pyridostigmine bromide was used to control clinical signs, and complete surgical removal of the thymoma and cholangiocellular carcinoma was performed. Serum acetylcholine receptor antibody concentration was measured serially. Clinical remission defined as resolution of clinical signs alongside discontinuation of treatment was achieved by day 251 (8.2 months). Immune remission defined as normalization of serum acetylcholine receptor antibody concentration alongside resolution of clinical signs and discontinuation of treatment was achieved by day 566 (18.5 months). Neurological examination was normal, and the owners did not report any clinical deterioration during the final follow-up appointment on day 752 (24 months), hence outcome was considered excellent. This is the first report describing the temporal evolution of serum acetylcholine receptor antibody concentration in a dog with thymoma-associated myasthenia gravis which achieved immune remission following thymectomy. Treatment was successfully discontinued without any evidence of clinical deterioration thereafter despite serum acetylcholine receptor antibody concentration not normalizing for another 315 days (10 months).
Spontaneous Tumor Lysis Syndrome in a Patient with a Dedifferentiated Endometrial Adenocarcinoma
Authors: Shinichi Harada, Keiki Nagaharu, Youichirou Baba, Tetsuya Murata, Toshiro Mizuno, Keiki Kawakami
Journal: Case Rep Oncol Med (2017)
MeSH terms: Case Reports

Tumor lysis syndrome (TLS) is an oncological emergency caused by massive cytolysis of malignant cells. This syndrome eventually induces metabolic abnormalities. TLS is observed mainly among tumors with rapid cell proliferation or high sensitivity to antineoplastic treatment. In rare cases, TLS occurs without any cytotoxic treatment. Previous reports have shown that alternative stress including proceeding infection or an operation might play a role in TLS. However, exact mechanism of spontaneous TLS remains unknown. Here, we describe a case of a 59-year-old woman who presented with dedifferentiated endometrial adenocarcinoma and developed TLS without any cytotoxic chemotherapy. Although spontaneous TLS in solid malignancies are extremely rare, clinicians should consider the possibilities of TLS especially in aggressive solid tumors.
Perforated Duodenal Diverticulum with Subtle Pneumoretroperitoneum on Abdominal X-Ray
Authors: Yuzeng Shen, Mark Kwok Fai Leong
Journal: Case Rep Emerg Med (2017)
MeSH terms: Case Reports

Abdominal pain is one of the most common presenting complaints at the Emergency Department (ED). Given the myriad of possible differential diagnoses for abdominal pain, it becomes more important to diagnose conditions requiring emergent surgical intervention early. We present a case of an elderly male patient with abdominal pain secondary to perforated hollow viscus, subtle evidence of pneumoretroperitoneum on the initial supine abdominal X-ray, and review the signs of pneumoperitoneum and pneumoretroperitoneum on plain abdominal X-rays.
Laparoscopic cholecystectomy in situs inversus totalis: a case report
Authors: Damian McKay, Geoffrey Blake
Journal: BMC Surg (2005)
MeSH terms: Cholecystectomy, Laparoscopic / methods, Cholecystitis / surgery, Gallbladder / abnormalities, Situs Inversus / surgery, Case Reports, Adult, Cholecystitis / complications, Cholecystitis / diagnostic imaging, Female, Humans, Situs Inversus / complications, Ultrasonography

Background:
Laparoscopic cholecystectomy is one of the commonest surgical procedures carried out in the world today. Occasionally patients present with undiagnosed situs inversus and acute cholecystitis. We discuss one such case and outline how the diagnosis was made and the pitfalls encountered during surgery and how they were overcome.
Case presentation:
A 32 year old female presented to our department with epigastric pain radiating through to the back. A diagnosis of acute cholecystitis in a patient with situs inversus totalis was made following clinical examination and radiological investigation. Laparoscopic cholecystectomy was subsequently performed and the patient made an uneventful recovery.
Conclusion:
Situs inversus presenting with acute cholecystitis is very rare. The surgeon must appreciate that care should be taken to set up the operating theatre in the mirror image of the normal set-up for cholecystectomy, and that right handed surgeons must modify their technique to adapt to the mirror image anatomy.
Massive Biventricular Thrombi in a Patient with Endometrial Adenocarcinoma Diagnosed on Computed Tomography Angiography
Authors: Shiva Barforoshi, Justin Sharim, Matthew J Budoff
Journal: Clin Med Insights Cardiol (2023)
Keywords: biventricular thrombi, computed tomography angiography, embolism, intracardiac thrombus, malignancy
MeSH terms: Case Reports

Biventricular thrombi are a rare clinical entity and only reported in several case reports. Given ventricular thrombi are high risk for cardioembolic events, accurate detection and therapeutic management has an important influence on clinical outcomes. We present a case of a patient with biventricular thrombi that was initially diagnosed on computed tomography angiography, emphasizing its clinical utility as a rapid, non-invasive imaging modality for early detection.
Acute Exacerbation of Hypereosinophilic Syndrome Complicated With Dermatitis, Enteritis, and Myositis: A Case Report
Authors: Yuki Takebuchi, Airi Minatogawa, Yumi Naito, Chiaki Sano, Ryuichi Ohta
Journal: Cureus (2023)
Keywords: abnormal rise of eosinophils, acute onset weakness, chronic urticaria, eosinophilic gastroenteropathy, eosinophilic myositis with chronic diarrhea, general medicine, hypereosinophilic syndrome, myalgia, rural hospital
MeSH terms: Case Reports

Hypereosinophilic syndrome is a disease that presents with a variety of symptoms caused by an abnormal rise in eosinophils in the blood and infiltration into various organs. Typical symptoms include skin symptoms and diarrhea. Diagnosis may be difficult because of the self-limiting phases of the disease with various symptoms. In addition, diagnosis may be delayed by the presence of rare concomitant symptoms, such as muscle pain and numbness. Here, we report the case of a 67-year-old patient with asymptomatic hypereosinophilia with chronic diarrhea, acute-onset weakness, and myalgia. We diagnosed eosinophilic gastroenteropathy, chronic urticaria, and eosinophilic myositis through multiple biopsies of the skin and colon. This case shows that chronic hypereosinophilic syndrome can be exacerbated transiently with acute symptoms and that prompt examination and treatment of hypereosinophilic syndrome based on the involved organs is recommended in a background of eosinophilia.
Single Solitary Fibrous Tumor Brain Metastasis in a Patient with Simultaneous Adenocarcinoma of the Lung: Case Report and Review of the Literature
Authors: Erin A Kaya, Jonathan D Carlson, Cheddhi J Thomas, Aaron E Wagner, Robert K Fairbanks, Wayne T Lamoreaux, Christopher M Lee
Journal: Case Rep Med (2020)
MeSH terms: Case Reports

We present a unique case of a patient simultaneously diagnosed with solitary fibrous tumor (SFT) and unrelated adenocarcinoma of the lung, both proven with separate pathology. It was subsequently found that the SFT had metastasized to the brain by additional pathology, and not the predicted adenocarcinoma. SFTs are a rare mesenchymal neoplasm that accounts for less than 2% of all reported soft tissue tumors. SFTs most commonly arise in the thoracic cavity, but are frequently found in various locations throughout the body, and rarely metastasize to the brain. This case highlights that rare neoplasms, such as SFT, should not be ruled out as a potential cause of metastasis. Due to the rarity of this clinical situation, we also provide a review and discussion of previously reported SFT cases and the use of postoperative radiation therapy. The optimal treatment for individual patients remains unclear in this unique situation. Surgical resection followed by adjuvant Gamma Knife radiation therapy to the surgical bed appears to be a safe option for local treatment of SFT in select patients. Further studies are needed of this rare clinical situation in order to better understand and optimize future treatments for patients with SFT and metastasis to the brain.
Percutaneous Closure of Patent Foramen Ovale after Anterior Spinal Cord Infarction
Authors: João Ferreira Reis, Petra Loureiro, Rita Lopes Silva, José Diogo Martins
Journal: Case Rep Cardiol (2022)
MeSH terms: Case Reports

In patients with a patent foramen ovale (PFO) who have had a cryptogenic ischemic stroke, percutaneous closure reduces its recurrence risk. However, its role in spinal cord infarction (SCI) is less well-established. A few case reports describe the putative causative role of PFO in SCI. We present a case of a teenager with cryptogenic anterior SCI in the setting of a deep vein thrombosis and a high risk-PFO who underwent successful percutaneous closure.
Management of Severe COVID-19 in Pregnancy
Authors: Yassamine Abourida, Houssam Rebahi, Imane Oussayeh, Hajar Chichou, Bouchra Fakhir, Abderraouf Soummani, Hicham Jalal, Fatiha Bennaoui, Nadia El Idrissi Slitine, Fadl Mrabih Rabou Maoulainine, Ahmed Rhassane El Adib, Mohamed Abdenacer Samkaoui
Journal: Case Rep Obstet Gynecol (2020)
MeSH terms: Case Reports

The scarcity of data concerning pregnant patients gravely infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) makes their management difficult, as most of the reported cases in the literature present mild pneumonia symptoms. The core problem is laying out evidence on coronavirus's implications on pregnancy and delivery, as well as vertical transmission and neonatal mortality. A healthy 30-year-old pregnant woman, gravida 6, para 4, at 31 weeks of gestation, presented severe pneumonia symptoms promptly complicated with premature rupture of membranes (PROM). A nasopharyngeal swab returned positive for SARS-CoV-2 using reverse transcription polymerase chain reactions (RT-PCR). The parturient underwent a cesarean delivery. This paper is an attempt to outline management of the critical condition of COVID-19 during pregnancy.
Case Report: Adult Post-COVID-19 Multisystem Inflammatory Syndrome and Thrombotic Microangiopathy
Authors: Idris Boudhabhay, Marion Rabant, Lubka T Roumenina, Louis-Marie Coupry, Victoria Poillerat, Armance Marchal, Véronique Frémeaux-Bacchi, Khalil El Karoui, Mehran Monchi, Franck Pourcine
Journal: Front Immunol (2021)
Keywords: covid-19, case report, complement system, eculizumab, multisystem inflammatory syndrome, thrombotic microangiopathy
MeSH terms: Antibodies, Monoclonal, Humanized / therapeutic use, COVID-19 / diagnosis, Complement Inactivating Agents / therapeutic use, Kidney / metabolism, SARS-CoV-2 / physiology, Systemic Inflammatory Response Syndrome / diagnosis, Thrombotic Microangiopathies / diagnosis, Case Reports, COVID-19 Drug Treatment, Humans, Kidney / pathology, Male, Middle Aged, Pandemics, Recovery of Function, Systemic Inflammatory Response Syndrome / drug therapy, Thrombotic Microangiopathies / drug therapy, Antibodies, Monoclonal, Humanized, Complement Inactivating Agents, adult multisystem inflammatory disease, COVID-19 related, eculizumab

Background:
The coronavirus disease 2019 (COVID-19) pandemic has affected millions of people worldwide. A clinical series of Kawasaki-like multisystem inflammatory syndrome (MIS), occurring after SARS-CoV-2 infection, have been described in children (MIS-C) and adults (MIS-A), but the pathophysiology remains unknown.
Case presentation:
We describe a case of post-COVID-19 MIS-A in a 46-year-old man with biopsy-proven renal thrombotic microangiopathy (TMA). Specific complement inhibition with eculizumab was initiated promptly and led to a dramatic improvement of renal function.
Conclusion:
Our case suggests that that TMA could play a central role in the pathophysiology of post-COVID-19 MIS-A, making complement blockers an interesting therapeutic option.
Successful Ultra-Minimally Invasive Endoscopic Intrarenal Surgery for 2-Year-Old Boy with Bilateral Cystine Kidney Stones Over 2 cm
Authors: Takaaki Inoue, Masato Watanabe, Seiji Shimada, Hidefumi Kinoshita, Tadashi Matsuda
Journal: J Endourol Case Rep (2018)
Keywords: cystine stones, pediatric kidney stones, ultra-minimally invasive endoscopic intrarenal surgery
MeSH terms: Case Reports

Background: Treatment of upper urinary tract stones measuring >2 cm in children aged <3 years is challenging. Although adult-sized instruments are usually available, in pediatric populations such instruments seem unreasonable and unfit for children with small kidneys and narrow ureters. We use ultra-miniaturized endoscopes and instruments to reduce the damage to normal tissues in pediatric patients. Case Presentation: We treated a 2-year-old boy with >2-cm bilateral cystine kidney stones. We decided to perform retrograde intrarenal surgery using an ultrathin (4.5F) semi-rigid ureteroscope for the right kidney stone (2.0 × 1.2 cm) in the lithotomy position and super ultra-minimally invasive endoscopy combined with intrarenal surgery with a percutaneous 8.5F to 9.5F tract sheath for the left kidney stone (3.5 × 2.4 cm) under the Barts modified Valdivia position. These procedures were successful for the bilateral kidney stones. Postoperatively, the patient was stone-free without major complications. Conclusion: We believe that ultra-minimally invasive endoscopic intrarenal surgery is safe and efficient in pediatric patients. Furthermore, the Barts modified Valdivia position was safely utilized in our 2-year-old patient with multiple large kidney stones.