OpenMed/multicare-articles huggingface dataset:
Intraoperative catheter directed thrombolytic therapy for the treatment of superior mesenteric and portal Vein thrombosis
Authors: M Marshad, M Maresch, T Al Abbasi
Journal: Int J Surg Case Rep (2018)

Introduction and case presentation:
Acute portal and superior mesenteric vein thrombosis(SMV) is a rare but potentially lethal condition that is often characterized by generalized and non-specific symptoms. A high index of suspicion is warranted for early diagnosis and management. We present a case of 54 year old male who presented with generalized abdominal pain which was later accompanied by hemodynamic instability and radiological diagnosis of portal vein and superior mesenteric vein thrombosis.
Discussion:
The management of SMV can be divided into medical and surgical therapy. Patients who have clear signs of peritonitis will require emergent surgery. Interventions for life-threatening portal vein thrombosis are limited and poorly described in the literature.
Conclusion:
We report a case of extensive portal vein thrombosis(PVT) advancing proximally to involve the superior mesenteric vein. Rapid portal vein patency and improved hepatic function was achieved with the direct use of tissue plasminogen activator infusion via operatively placed middle colic vein catheter.
Case report - Asterixis Post High Frequency Focused-Ultrasound Thalamotomy
Authors: Ashley Mears, Ali R Rezai, Richa Tripathi
Journal: Tremor Other Hyperkinet Mov (N Y) (2022)
Keywords: focused ultrasound thalamotomy, asterixis, myoclonus
MeSH terms: Deep Brain Stimulation / methods, Essential Tremor / diagnostic imaging, Essential Tremor / surgery, Myoclonus / therapy, Case Reports, Aged, Humans, Male, Thalamus / diagnostic imaging, Thalamus / surgery, Ultrasonography / methods

Background:
High frequency focused ultrasound is used for treatment of essential tremor. Side effects associated with the procedure may resolve over time. We report a case of negative myoclonus, which has not been reported with this procedure.
Case report:
A 73-year-old left-handed man underwent focused ultrasound thalamotomy for treatment of essential tremor. Immediately post procedure he was noted to have negative myoclonus in the treated limb. This side effect resolved over the course of 6 months.
Discussion:
Although asterixis has been associated with thalamic infarcts in the past, this has not yet been reported in the literature with MRgFUS procedure and is a novel observation. Occupational and physical therapy may be considered to address this side effect. It is important to counsel patients about the rare occurrence of this complication of therapy but also its potential for complete resolution over time.
Gangrene of the penis in a diabetic male with multiple amputations and follow up
Authors: P Vijayan
Journal: Indian J Urol (2009)
Keywords: amputation, diabetic, gangrene, penis
MeSH terms: Case Reports

A 60-year-old insulin dependent, diabetic male with severe atherosclerosis requiring multiple amputations in the extremities in the past, with normal renal function presented with gangrene of glans penis. He was initially treated with debridement but as the gangrene progressed, partial penile amputation was performed. He showed no further progress of the disease and had no voiding difficulties even after 4 years of follow up.
West Nile virus encephalitis in GATA2 deficiency
Authors: Jaime S Rosa, Shanthi Kappagoda, Amy P Hsu, Joie Davis, Steven M Holland, Anne Y Liu
Journal: Allergy Asthma Clin Immunol (2019)
Keywords: encephalitis, gata2, immunoglobulin, interferon, west nile virus
MeSH terms: Case Reports

We report a male with longstanding warts who presented with severe West Nile virus encephalitis (WNVE) and recovered after interferon alfa-2b and intravenous immunoglobulin. He was later found to have GATA2 deficiency and underwent successful hematopoietic stem cell transplant.
Cytological features of mammary analogue secretory carcinoma of the parotid gland in a 15-year-old girl: a case report with review of the literature
Authors: Takako Inaba, Yuki Fukumura, Tsuyoshi Saito, Junkichi Yokoyama, Shinichi Ohba, Atsushi Arakawa, Takashi Yao
Journal: Case Rep Pathol (2015)

Mammary analogue secretory carcinoma (MASC) is a recently recognized tumor of salivary glands characterized by the ETV6-NTRK3 fusion gene. This tumor is very rare in children and adolescents. We report a case of MASC in a 15-year-old girl, the fifth youngest case so far reported. The patient complained of a left infra-auricular mass that gradually enlarged for a year. Fine-needle aspiration cytology/imprint cytology showed individual tumor cells that had faintly eosinophilic granular cytoplasm with secretion granules sometimes seen adjacent to the tumor cells. These cytological features overlapped between those of zymogen granule-poor acinic cell carcinoma (AciCC) and MASC. In addition to the case report, we present a review of the related literature with a focus on the cytological features of MASC. The differential diagnostic clues are also discussed.
Malaria and an Amoebic Abscess in a Returning Traveler from Liberia
Authors: Mhd Mustafa Albitar, Nafiza Martini, Sandy Alkhalil, Tamim Alsuliman, Ali Alrstom
Journal: Case Rep Infect Dis (2023)
MeSH terms: Case Reports

Malaria is an infectious Anopheles mosquito-borne disease caused by five different eukaryotic protozoa parasites. Amoebiasis is a parasitic infection caused by Entamoeba histolytica. Both diseases are widespread in Liberia. A returning traveler was diagnosed and treated for malaria, and 20 days later, an amoebic liver abscess was discovered, meaning that the malaria infection masked the amoebic infection, which emphasizes the importance of a complete examination of returning travelers, especially for those returning from Sub-Saharan Africa, where coinfections are more common. Herein, we propose that the relationship between Malaria and amoebic liver abscesses should be explored by researching the effects of malaria on ferritin levels and the immune components in the liver and whether it helps the emergence of hepatic amoebic abscesses or not.
Acute systemic viral infection masquerading as an infiltrating lymphoma in an elderly patient: a case report and review of the literature
Authors: Hani M Babiker, Troy Wiedenbeck, Ryan S Robetorye, Utkarsh Acharya, Susan Wilansky, Shimon Kusne
Journal: Case Rep Med (2013)

Primary Epstein-Barr virus (EBV) infection occurs mainly in adolescents and young adults, with more than 90% of adults having serological evidence of past infection. Primary infection in those over the age of 40 is associated with an atypical and often more severe presentation that can lead to more extensive and invasive, and often unnecessary, diagnostic testing. The incidence of severe EBV-related illness in older adults has been observed to be increasing in industrialized nations. The characteristic presentation of infectious mononucleosis (IM) syndrome in elderly patients (age > 65) is not clearly defined in the literature. Here, we describe a case of primary EBV infection in an 80-year-old female and review the literature regarding primary seroconversion in elderly patients.
Coexistence of Congenital Adrenal Hyperplasia and Autoimmune Addison's Disease
Authors: Sigrid Aslaksen, Paal Methlie, Magnus D Vigeland, Dag E Jøssang, Anette B Wolff, Ying Sheng, Bergithe E Oftedal, Beate Skinningsrud, Dag E Undlien, Kaja K Selmer, Eystein S Husebye, Eirik Bratland
Journal: Front Endocrinol (Lausanne) (2019)
Keywords: 3β-hydroxysteroid dehydrogenase type 2 deficiency, adrenal insufficiency, autoimmune addison's disease, autoimmune adrenalitis, congenital adrenal hyperplasia
MeSH terms: Case Reports

Background: Underlying causes of adrenal insufficiency include congenital adrenal hyperplasia (CAH) and autoimmune adrenocortical destruction leading to autoimmune Addison's disease (AAD). Here, we report a patient with a homozygous stop-gain mutation in 3β-hydroxysteroid dehydrogenase type 2 (3βHSD2), in addition to impaired steroidogenesis due to AAD. Case Report: Whole exome sequencing revealed an extremely rare homozygous nonsense mutation in exon 2 of the HSD3B2 gene, leading to a premature stop codon (NM_000198.3: c.15C>A, p.Cys5Ter) in a patient with AAD and premature ovarian insufficiency. Scrutiny of old medical records revealed that the patient was initially diagnosed with CAH with hyperandrogenism and severe salt-wasting shortly after birth. However, the current steroid profile show complete adrenal insufficiency including low production of pregnenolone, dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEA-S), without signs of overtreatment with steroids. Conclusion: To the best of our knowledge, this is the first description of autoimmune adrenalitis in a patient with 3βHSD2 deficiency and suggests a possible association between AAD and inborn errors of the steroidogenesis.
Case report: Significant relief of linezolid-induced peripheral neuropathy in a pre-XDR-TB case after acupuncture treatment
Authors: Yuping Mo, Zhu Zhu, Jie Tan, Zhilin Liang, Jiahui Wu, Xingcheng Chen, Ming Hu, Peize Zhang, Guofang Deng, Liang Fu
Journal: Front Neurol (2022)
Keywords: acupuncture, adverse reactions, linezolid, multidrug-resistant tuberculosis, peripheral neuropathy
MeSH terms: Case Reports

The revised WHO guidelines on multidrug- or rifampicin-resistant tuberculosis (MDR/RR-TB) include linezolid in the core drug group. Common adverse events of prolonged linezolid use are bone marrow suppression and peripheral neuropathy (PN). Available measures against linezolid-induced PN (LIPN) often have insignificant effects, leading to linezolid discontinuation and a decline in the success rate of MDR/RR-TB treatment. Acupuncture treatment is a symptomatic treatment measure from traditional Chinese medicine (TCM) to relieve pain with overall very low evidence and has never been reported in LIPN. The pilot use of acupuncture in a pre-extensively drug-resistant (XDR)-TB (a more severe form of MDR/RR-TB) patient exhibited significant improvements in LIPN and thus maintained linezolid in the regimen for a longer period.
A Male Case of Kagami-Ogata Syndrome Caused by Paternal Unipaternal Disomy 14 as a Result of a Robertsonian Translocation
Authors: Xiaoxue Wang, Hui Pang, Birju A Shah, Hongcang Gu, Lijun Zhang, Hua Wang
Journal: Front Pediatr (2020)
Keywords: kagami–ogata syndrome, robertsonian translocation, heterodisomy, imprinting disorders, uniparental disomy
MeSH terms: Case Reports

Kagami-Ogata syndrome (KOS) is a rare imprinting disorder characterized by skeletal abnormalities, dysmorphic facial features, growth retardation and developmental delay. The genetic etiology of KOS includes paternal uniparental disomy 14 [upd(14)pat], epimutations and microdeletions affecting the maternally derived imprinted region of chromosome 14q32.2. More than seventy KOS cases have been reported thus far; however, only 10, including two familial, are associated with upd(14)pat harboring Robertsonian translocation (ROB). Here, we reported a male infant with clinical manifestations of facial dysmorphism, bell-shaped small thorax, and omphalocele. Karyotype analyses identify a balanced ROB involving the long arms of chromosomes 13 and 14 both in the patient and his father. We further confirm the pattern of upd(14)pat utilizing DNA polymorphic markers. In conclusion, our case report provides a new male KOS case caused by upd(14)pat with paternally inherited Robertsonian translocation, which represents the second male case officially reported. Notably, a KOS case due to upd(14)pat and ROB is rare. An accurate diagnosis requires not only the identification of the characteristic clinical features but also systemic cytogenetic and molecular studies.
Case Report: Expanding the Digenic Variants Involved in Thyroid Hormone Synthesis-10 New Cases of Congenital Hypothyroidism and a Literature Review
Authors: Rulai Yang, Yijun Lu, Chenxi Yang, Xiaoyu Wu, Junqi Feng, Ling Zhu, Qiang Shu, Pingping Jiang
Journal: Front Genet (2021)
Keywords: congenital hypothyroidism, digenic variants, genetic counseling, oligogenic cases, thyroid hormone synthesis
MeSH terms: Case Reports

Congenital hypothyroidism (CH) is the most common neonatal metabolic disorder. Although it has been understood to be a monogenic disease, some CH patients are reported to carry two or more variants at different genes. Here, ten permanent congenital hypothyroidism (PCH) patients were retrospectively reviewed, with elevated levels of serum thyroid-stimulating hormone and levothyroxine dependence during follow-up between 2015 and 2019. Each affected individual carried digenic variants, which were heterozygous at two of pathogenic genes. In total, five pathogenic genes, TSHR, TG, TPO, DUOX2 and DUOXA2, were simultaneously identified in subjects that were involved in the same metabolic pathway: thyroid hormone biosynthesis. There were digenic variants at TSHR and DUOX2 combined in three patients, DUOX2 and TG combined in two patients, DUOX2 and DUOXA2 combined in two patients, TG and DUOXA2 combined in two patients, and TG and TPO combined in one patient. Additionally, seven novel variants, TSHR c.679G>A, DUOX2 c.127A>T, c.608-619del, c.959T>C, TG c.2307G>A, and c.6759_6765del, and DUOXA2 c.93T>G, were identified in these PCH patients. Along with a literature review on digenic variants in patients with CH, our findings illustrated the complexity of genetic etiology in CH.
Case Report: Treatment of Penile Intraepithelial Neoplasia in an Asian Male With Reconstructive Plastic Surgery
Authors: Kai Huang, Shuai Lu, Yehua Wang, Xiangan Tu
Journal: Front Surg (2021)
Keywords: asian, case report, penile neoplasms, plastic, surgery
MeSH terms: Case Reports

Intraepithelial neoplasia is a special type of squamous cell carcinoma occurring in the skin epidermis. The incidence of penile intraepithelial neoplasia in Asian males is rare. We report the clinical characteristics and treatment process of a case of penile intraepithelial neoplasia in a Chinese man. We treated the disease of this patient by surgical excision of the penile lesion and scrotal flap plastic surgery. After surgery, the shape of the penis was satisfactory, and there was no adverse effect on erection. The pathological results confirmed the diagnosis of penile intraepithelial neoplasia. The pathological features showed that the lesion tissue was covered with squamous epithelium and that there was severe atypical hyperplasia of the lesion epithelium, disordered arrangement of polarity, and an intact basement membrane. The removal of the lesions of penile intraepithelial neoplasia through a wider surgical resection range, combined with the stretchability of a scrotal flap, can achieve a good healing effect of the surgical wound and reduce the possibility of recurrence of penile intraepithelial neoplasia.
An unusual biconvex epidural lesion: acutely presenting extraosseous intracranial Ewing's sarcoma
Authors: Kalimullah Jan, Eraj Khursheed Khan, Inamullah Khan
Journal: Chin Neurosurg J (2018)
Keywords: biconvex, brain neoplasm, epidural, ewing’s sarcoma, extra osseous, molecular analysis
MeSH terms: Case Reports

Background:
Ewing's sarcoma family of tumors consists of small round cell neoplasms, inclusive of primitive neuroectodermal tumor (PNET), Askin's tumor, and PNET of the bone. Extraosseous Ewing's sarcoma occurs commonly at bones of lower extremities and paravertebral region of the spine. It rarely presents as a primary intracranial lesion. When intracranial, it can be misdiagnosed as central PNET (e.g., medulloblastoma, pinealoblastoma, or supratentorial PNET), other intracranial lesions, or even as an epidural hematoma.
Case presentation:
We report the case of a 20-year-old patient who presented to the emergency department with complaints of drowsiness, headache, and fever for 1 day. On initial computed tomography (CT) scan of the brain, a right temporal biconvex epidural lesion involving squamous-temporal bone with periosteal reaction was noted.The patient underwent urgent craniotomy, and a tumor was found and excised. Biopsy report confirmed Ewing's sarcoma.
Conclusion:
Ewing's sarcoma is a rare intracranial malignancy with only a few cases reported in literature. In a young patient with a biconvex epidural lesion, in the absence of trauma or ongoing infection, the possibility of Ewing's sarcoma should be considered as well.
Coronavirus Disease 2019 (COVID-19) Manifestation as Acute Myocardial Infarction in a Young, Healthy Male
Authors: Prerak Juthani, Rohan Bhojwani, Neil Gupta
Journal: Case Rep Infect Dis (2020)
MeSH terms: Case Reports

Although a large part of the symptomology of coronavirus disease 2019 (COVID-19) has been attributed to its effects in the lungs, the virus has also been shown to cause extensive cardiovascular complications in a small subset of patients. In this case report, we describe a 29-year-old nonobese hospital food service associate who presented with diffuse abdominal and chest pain; he was found to be positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with significantly elevated levels of troponin T and multiple acute phase reactants; his EKG demonstrated ST-elevations consistent with anterolateral infarction. Despite having no significant past medical history or atherosclerotic risk factors, he was found to have a complete occlusion of his left anterior descending artery that required cardiac catheterization. This case demonstrates that cardiovascular complications must be considered in the COVID-19 population, even without the clear presence of other risk factors for heart disease.
Mixed Acinar-Endocrine Carcinoma (MAEC) Arising in Duodenal Pancreatic Heterotopia
Authors: Phoenix D Bell, Tom C DeRoche, Aaron R Huber
Journal: Case Rep Pathol (2019)
MeSH terms: Case Reports

Mixed acinar-endocrine carcinoma (MAEC) of the pancreas is a rare neoplasm, consisting of at least 25%-30% of acinar and neuroendocrine populations. Patients are often middle-aged and present with nonspecific symptoms. Imaging typically reveals a solid lesion in the pancreatic head. Management involves surgical resection and the overall prognosis is variable. Here, we present a case of a 48-year-old male who presented with a MAEC arising from duodenal pancreatic heterotopia. This is the one of the first cases, with histologic evidence, of MAEC arising from pancreatic heterotopia.
A rare case of anomalous origin of the left main coronary artery in an adult patient
Authors: Pierre O Dionne, Nancy Poirier, Jessica Forcillo, Louis M Stevens, Carl Chartrand-Lefebvre, Samer Mansour, Nicolas Noiseux
Journal: J Cardiothorac Surg (2013)
MeSH terms: Coronary Artery Bypass, Coronary Vessel Anomalies / surgery, Coronary Vessels / surgery, Case Reports, Adult, Chest Pain / etiology, Coronary Vessel Anomalies / diagnosis, Coronary Vessel Anomalies / pathology, Coronary Vessels / pathology, Dyspnea / etiology, Humans, Male

Anomalous origin of left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital anomaly that causes a left-to-right shunt via the coronary system, resulting in coronary steal. We report an unusual case of a healthy 48 years-old patient presenting with dyspnea on exertion and mild chest pain who underwent surgical correction of this rare anomaly. Multiple procedures have been proposed in adults with ALCAPA. Although re-implantation of the left main coronary artery (LMCA) to the aorta remains the most physiological correction for this anomaly, the combination of LMCA ligation and coronary artery bypass grafting provides a dual coronary flow system and is preferable when re-implantation is impossible.
Case Report: Pituitary metastasis as a presenting manifestation of silent gastric cardia adenocarcinoma
Authors: Andrea Ghezzi, Jessica Rossi, Francesco Cavallieri, Manuela Napoli, Rosario Pascarella, Romana Rizzi, Marco Russo, Gaetano Salomone, Antonio Romano, Corrado Iaccarino, Elisabetta Froio, Silvia Serra, Salvatore Cozzi, Lucia Giaccherini, Franco Valzania, Anna Pisanello
Journal: Front Oncol (2023)
Keywords: diabetes insipidus - neurogenic/central, gastroesophageal junction adenocarcinoma, hypopituitarism, pituitary metastasis, visual disturbance
MeSH terms: Case Reports

Introduction:
Pituitary metastases are very rare in cancer patients and often originate from lung or breast tumors. They usually occur in patients with known metastatic disease, but rarely may be the first presentation of the primary tumor.
Methods:
We present the case of a 58 years-old-man who reported a three-month history of polyuria-polydipsia syndrome, generalized asthenia, panhypopituitarism and bitemporal hemianopsia. Brain-MRI showed a voluminous pituitary mass causing posterior sellar enlargement and compression of the surrounding structures including pituitary stalk, optic chiasm, and optic nerves.
Results:
The patient underwent neurosurgical removal of the mass. Histological examination revealed a poorly differentiated adenocarcinoma of uncertain origin. A total body CT scan showed a mass in the left kidney that was subsequently removed. Histological features were consistent with a clear cell carcinoma. However, endoscopic examination of the digestive tract revealed an ulcerating and infiltrating adenocarcinoma of the gastric cardia. Total body PET/CT scan with 18F-FDG confirmed an isolated area of accumulation in the gastric cardia, with no hyperaccumulation at other sites.
Conclusion:
To the best of our knowledge, there are no reports of pituitary metastases from gastric cardia adenocarcinoma. Our patient presented with symptoms of sellar involvement and without evidence of other body metastases. Therefore, sudden onset of diabetes insipidus and visual deterioration should lead to the suspicion of a rapidly growing pituitary mass, which may be the presenting manifestation of a primary extracranial adenocarcinoma. Histological investigation of the pituitary mass can guide the diagnostic workup, which must however be complete.
Evaluation of district mental healthcare plans: the PRIME consortium methodology
Authors: Mary J De Silva, Sujit D Rathod, Charlotte Hanlon, Erica Breuer, Dan Chisholm, Abebaw Fekadu, Mark Jordans, Fred Kigozi, Inge Petersen, Rahul Shidhaye, Girmay Medhin, Joshua Ssebunnya, Martin Prince, Graham Thornicroft, Mark Tomlinson, Crick Lund, Vikram Patel
Journal: Br J Psychiatry (2016)
MeSH terms: Community Mental Health Services / standards, Mental Disorders / therapy, Patient Care Planning / standards, Program Evaluation / methods, Research Support, Non-U.S. Gov't, Cross-Sectional Studies, Developing Countries, Ethiopia, Humans, India, Nepal, Quality Improvement, South Africa, Surveys and Questionnaires, Uganda

Background:
Few studies have evaluated the implementation and impact of real-world mental health programmes delivered at scale in low-resource settings.
Aims:
To describe the cross-country research methods used to evaluate district-level mental healthcare plans (MHCPs) in Ethiopia, India, Nepal, South Africa and Uganda.
Method:
Multidisciplinary methods conducted at community, health facility and district levels, embedded within a theory of change.
Results:
The following designs are employed to evaluate the MHCPs: (a) repeat community-based cross-sectional surveys to measure change in population-level contact coverage; (b) repeat facility-based surveys to assess change in detection of disorders; (c) disorder-specific cohorts to assess the effect on patient outcomes; and (d) multilevel case studies to evaluate the process of implementation.
Conclusions:
To evaluate whether and how a health-system-level intervention is effective, multidisciplinary research methods are required at different population levels. Although challenging, such methods may be replicated across diverse settings.