OpenMed/multicare-articles huggingface dataset:
Case report: Bilateral optic nerve sheath meningocele: clinical aspects
Authors: Saray Catalán-Coronado, Alba Parrado-Carrillo, Javier Nogués-Castell, Josep Rosinés-Fonoll, Anna Camós-Carreras, Rafel Alcubierre, Maria Teresa Carrión-Donderis, Carolina Bernal-Morales, Bernardo Sánchez-Dalmau
Journal: Front Ophthalmol (Lausanne) (2024)
Keywords: diplopia, neuroopthalmology, optic nerve, optic nerve sheath meningocele, visual field
MeSH terms: Case Reports

Optic nerve sheath meningocele is an enlargement of the sheath itself, consisting of a collection of cerebrospinal fluid along the perineural space. It should be considered primary if it is not associated with orbital-cerebral neoplasm or with cranio-orbital junction malformations. We report three cases of bilateral primary idiopathic optic nerve sheath meningocele, two of them with gradual vision loss. The first case presented a history of monocular blurred vision of the right eye and headache. It was initially treated with acetazolamide without any improvement, after which optic nerve sheath fenestration was required. The second case showed intermittent binocular diplopia with central 24-2 perimetry defects in the left eye. The third case was first presented as a subacute bilateral conjunctivitis with a suspected orbital pseudotumor. An incidental bilateral optic nerve sheath meningocele was found in the orbital imaging, being totally asymptomatic. In all the cases, orbital and cranial magnetic resonance with contrast and fat suppression was crucial in the diagnosis.
Infrequent Pediatric Subungual Injury Diagnosed by Intraoperative Anatomopathological Material: A Case Report
Authors: Alberto Daniel Navarro Vergara, Alberto Navarro Fretes, María Mercedes Medina Villate
Journal: Cureus (2024)
Keywords: benign bone tumor, female pediatric patient, hallux, infrequent subungual injury, onychogryphosis, periungual edge impingement, subungual exostosis, tumor exeresis
MeSH terms: Case Reports

Subungual lesions are very common in clinical practice. We present the clinical case of a 10-year-old female patient who presented with progressive nail deformity. The onset of the condition was approximately five years prior to presentation with an injury in the left hallux, according to the mother. She denied pain or change in the color of the area from the onset of the injury to the day of consultation. There was no previous trauma. Examination revealed subungual bone injury to the distal extremity (distal phalanx of the left hallux), and imaging tests (X-ray and soft tissue ultrasound) found bone injury. Subungual exostosis was considered as a possible diagnosis, thus prompting the indication for exeresis of the tumoral process. After surgical removal, the resected specimen was sent for pathological assessment, which found that an intraosseous hemangiolymphangioma was the origin of the tumor. A subungual exostosis is a slow-growth benign osseous tumor mainly located in the distal phalanx of the hallux that especially affects young adults, being less frequent in children. This condition results from a process of bone neoformation involving different stages, the clinical symptoms of which depend on its size and associated processes. Hemangiolymphangiomas are angiomatous lesions of the blood and lymphatic vessels that have a controversial etiology and present slow, painless, and progressive growth; these lesions are mostly benign. It is worth emphasizing that subungual injuries are not always caused by an underlying bone; therefore, potential differential diagnoses, both benign and malignant, should be considered, based on the location of the injury.
Case Report: Successful treatment of external beam radiation-induced optic papillopathy with intravitreal anti-VEGF
Authors: Andrew R Carey
Journal: Front Ophthalmol (Lausanne) (2023)
Keywords: radiation, anti-vegf (vascular endothelial growth factor), bevacizumab (avastin), intravitreal (ivt) drug, intravitreal bevacizumab (ivb, avastin), optic disk edema, optic neuropathy, optic papillopathy
MeSH terms: Case Reports

Three cases of optic disc edema arising from radiation optic neuropathy isolated to the intra-ocular optic nerve following external beam radiation for head and neck squamous cell carcinoma are presented. A literature review of the etiology, presentation, and treatment is included for discussion, along with proposed diagnostic criteria.
Thinking Twice about the Cervical Mass: A Case Report of Primary Vaginal Leiomyosarcoma and Review of the Literature
Authors: Caroline C Davitt, Yingao Zhang, Anthony B Costales
Journal: Case Rep Obstet Gynecol (2024)
MeSH terms: Case Reports

Primary vaginal leiomyosarcoma (LMS) is an unusual cause of aggressive gynecologic cancer which requires prompt surgical treatment for favorable outcomes. Definitive diagnosis and treatment render unique challenges to clinicians based on vague presentation and limited evidence for management. Here, we describe a case of vaginal LMS in a middle-aged woman with a history of cervical dysplasia found to have a proximal vaginal mass after presenting with vaginal discharge and cramping pain. The patient was diagnosed on pathologic surgical specimen and subsequently underwent definitive surgical treatment. She remains with no evidence of disease 20 months later. In our report, we emphasize the nuances of surgical management including localized source control in those desiring future fertility. Ultimately, we make recommendations for surgical treatment and surveillance based on the available published literature.
Accident due to Incorrect Selection of Diode Laser Technique in the Treatment of Oral Venous Malformation
Authors: Mohamed Mohsen, Guido Migliau, Daniele Pergolini, Umberto Romeo, Gaspare Palaia
Journal: Case Rep Dent (2023)
MeSH terms: Case Reports

Venous malformation (VM) originates from a congenital venous network disorder, configuring about 40% of the vascular anomalies that occur in the head and neck region. The usage of diode lasers in the treatment of VM is associated with various advantages, such as short operating time and few postoperative complications. Nevertheless, for larger and deeper VM treatment, it may require more than one session for the complete resolution of the lesion. Laser surgery for oral VM may induce heat accumulation due to excessive irradiation causing adverse events postoperatively, including pain and ulcer formation with scarring. In this clinical case, it was recommended to use the leopard technique (LT) to reduce the lesion size, evaluate the remaining unhealed lesion, and apply different laser techniques to obtain the complete resolution of the lesion.
A Pelvic Abscess and a Pelvic Stone Secondary to a Ureteral Calculus
Authors: Bo-Ran An, Ze-Peng Ma, Chao Gao
Journal: Case Rep Radiol (2024)
Keywords: pelvic abscess, pelvic stone, ureteral calculus
MeSH terms: Case Reports

The patient presented with abdominal pain for the first time 10 years ago and was diagnosed with a left ureteral calculus, left hydronephrosis, and hydroureter. The patient's abdominal pain disappeared after palliative treatment, but he refused any treatment measures for his calculus and hydrops. He was readmitted due to chronic pelvic pain 8 years ago and was diagnosed with a pelvic abscess and left renal atrophy after imaging examination. We performed pus aspiration treatment under the guidance of transrectal B-mode ultrasound and used antibiotic fluid for purulent cavity rinse, followed by intravenous injection of antibiotics. The abscess shrank in follow-up magnetic resonance imaging (MRI), and the pain symptom disappeared in his pelvic. We followed up with the patient for 6 months, and he had no symptoms related to his pelvic abscess that was diagnosed before. Recent abdominal computed tomography (CT) images revealed that his left kidney atrophy still exists, and a pelvic stone was found at the site of the original abscess. This case once again proves that a ureteral calculus should be treated in time; otherwise, it can lead to serious complications such as a pelvic abscess and renal atrophy. A pelvic stone can be caused by a ureteral calculus migration. Minimally invasive treatments have minimal damage to the body and are widely applicable, and the patient was cured by one of them, abscess aspiration, which implies that they can also be used for patients who cannot tolerate surgical procedures.
Laser-Assisted Surgical Management of Oral Mucocele: A Case Report
Authors: Sourabh Shinde, Vidya Lohe, Unnati Shirbhate, Swapnil Mohod, Dhruvi Solanki
Journal: Cureus (2024)
Keywords: diode laser, extravasation phenonmenon, histopath, mucocele, retention
MeSH terms: Case Reports

This case represents mucocele of extravasation phenomenon associated with a lower lip on the right side in the last 15 days. A 19-year-old male patient visited the outpatient department with a history of constant trauma due to lip biting and due to soft and flocculent consistency on palpation, mucocele was considered under the provisional diagnosis. The borders of the lesion were marked following all the protocols of asepsis and sterilization and laser-assisted surgical excision was undertaken resulting in total removal of the lesion with a diode laser by resecting it from the base to reduce chances of re-occurrence. The specimen that was resected was sent for histopathological examination, which confirmed the final diagnosis of mucous extravasation cyst or mucocele. The following report underlines that laser-assisted resection offers a minimally invasive and precision approach for the treatment of mucocele.
Case Report: CD19 and CD20 monoclonal antibodies with sequential chemotherapy for refractory acute B-lymphocytic leukemia in children
Authors: Jia-Nan Li, Yu Li, Ji-Xun Lin, Li-Na Wang, Xiao-Li Zhang, Juan Ouyang, Du-Bo Chen, Shao-Qian Chen, Jun-Xun Li, Xue-Qun Luo, Yan-Lai Tang, Li-Bin Huang
Journal: Front Immunol (2023)
Keywords: allo hematopoietic stem cell transplantation, blinatumomab, minimal residual disease, refractory acute b-lymphocytic leukemia, rituximab
MeSH terms: Hematopoietic Stem Cell Transplantation, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy, Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy, Case Reports, Antibodies, Monoclonal / therapeutic use, Bone Marrow, Child, Preschool, Humans, Male, Antibodies, Monoclonal

Objective:
This paper observes the efficacy of chemotherapy combined with CD19 and CD20 monoclonal antibodies in clearing minimal residual disease (MRD) and bridging transplantation for refractory acute B-lymphoblastic leukemia (B-ALL) in children and reviews the literature.
Methods:
A 4-year-old boy diagnosed with B-ALL in our hospital was treated with the SCCLG-ALL-2016 protocol. MRD and gene quantification decreased after induction but remained persistently positive, with poor efficacy. After this patient received three cycles of consolidation chemotherapy combined with blinatumomab and rituximab, MRD and fusion gene quantification became negative, and he received allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Results:
During the use of monoclonal antibodies, neurotoxicity, CRS, or other side effects did not occur. Before transplantation, MRD became negative, and the bone marrow had been in complete remission since transplantation (13 months).
Conclusion:
Chemotherapy combined with blinatumomab for refractory B-ALL in children can bring a better remission rate for patients and is a means of bridging transplantation. Nevertheless, sequential CD20 monoclonal antibody therapy is the first report , and no adverse effects were observed in our case. It is well tolerated and can be used as one of the treatments for refractory B-ALL.
Case report: Cardiac neuroendocrine carcinoma and squamous cell carcinoma treated with MR-guided adaptive stereotactic radiation therapy
Authors: Xinru Chen, Julius K Weng, Angela Sobremonte, Belinda M Lee, Neil W Hughes, Mustefa Mohammedsaid, Yao Zhao, Xiaochun Wang, Xiaodong Zhang, Joshua S Niedzielski, Sanjay S Shete, Laurence E Court, Zhongxing Liao, Percy P Lee, Jinzhong Yang
Journal: Front Oncol (2024)
Keywords: mr-linac, mr-guided radiotherapy, sbrt, cardiac metastasis, cardiac tumor
MeSH terms: Case Reports

We present two cases of cardiac metastases adjacent to the right ventricle in a 55-year-old male and a 61-year-old female, both treated with magnetic resonance (MR)-guided adaptive stereotactic radiation therapy (SBRT). The prescribed regimen was 30Gy delivered in 3 fractions using a 1.5 Tesla magnetic resonance linear accelerator (MR-linac). Patients exhibited favorable tolerance to the treatment, with no observed acute toxicity.
Colon Lipoma Causing Colo-Colic Intussusception in an Adult: A Case Report from Tanzania
Authors: Jamil Suleiman, Mujaheed Suleman, Alex Mremi, Adnan Sadiq, Abbas Mohamedali, Dennis Machaku, Jay Lodhia
Journal: Case Rep Surg (2024)
MeSH terms: Case Reports

Intussusception is rarely seen in adulthood but is commonly seen in the pediatric age group. Causes of intussusception in adults are commonly due to tumors and inflammatory diseases. Intussusception in adults accounts for less than 5% of intestinal obstruction. Colonic lipomas are usually asymptomatic and are mostly managed surgically with promising outcomes as seen in our case.
Acrofacial vitiligo secondary to PI3KCA inhibitor, alpelisib: case report
Authors: Maayan Geller Hinich, Adham Hijab
Journal: Front Oncol (2023)
Keywords: pik3ca, alpelisib, breast cancer, skin adverse effects, vitiligo
MeSH terms: Case Reports

Alpelisib plus fulvestrant is a valid second or advanced line of treatment for patients with metastatic hormone receptor (HR)-positive, HER2-negative breast cancer who harbor an activating PIK3CA mutation. The well-known side effects of alpelisib are hyperglycemia, rash, and diarrhea. Herein, we report a case of a woman who developed diffuse depigmented macules on the face, arms and legs, three months after initiating alpelisib. Both clinical and histopathological findings were consistent with new-onset vitiligo. To our knowledge, this is the first case described in literature which suggests a causal relationship between alpelisib and irreversible dermatological adverse effect.
Case report-CARMAT: the first experience with the Aeson bioprosthetic total artificial heart as a bridge to transplantation in a case of post-infarction ventricular septal rupture
Authors: Katharina Huenges, Bernd Panholzer, Jochen Cremer, Assad Haneya
Journal: Front Cardiovasc Med (2023)
Keywords: vsd, heart failure, heart transplantation, myocardial infarction, total artificial heart
MeSH terms: Case Reports

Background:
Post-infarction ventricular septal defects remain one of the most feared complications after myocardial infarction with high mortality rates. In special cases, surgical or interventional treatment strategies are technically not feasible and do not always lead to a good outcome.
Case presentation:
A 58-year-old male patient in cardiogenic shock with a very large ventricular septal (VSD) defect (4.9 cm × 5 cm) due to myocardial infarction was presented in our department. Acute stabilization was achieved using peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO) support. Neither surgical nor interventional therapy was considered as a sufficient option due to the unsuitable anatomy of the VSD and the patient was listed for heart transplantation. After 2 weeks on ECMO, bleeding and infectious complications occurred. Due to organ shortage, urgent implantation of the bioprosthetic total artificial heart (TAH) Aeson device (CARMAT) remained the only useful strategy to achieve a mid- or long-term bridge to transplantation. After successful implantation and good recovery with the Aeson device, the patient was transplanted 4 weeks after implantation.
Conclusion:
Post-infarction ventricular septal defects are highly challenging and are commonly associated with a poor prognosis. The implantation of the new Aeson TAH device is a promising therapeutic option, allowing a safe and long-term bridging to heart transplantation.
Peritoneal tuberculosis: a benign differential diagnosis of ovarian cancer with peritoneal carcinomatosis (a case report)
Authors: Anas Ahallat, Mohamed Al Amine El Mouden, Younes Aggouri, Said Ait Laalim
Journal: Pan Afr Med J (2023)
Keywords: peritoneal tuberculosis, case report, laparoscopy, ovarian cancer
MeSH terms: Laparoscopy, Ovarian Neoplasms / diagnosis, Ovarian Neoplasms / pathology, Peritoneal Neoplasms / diagnosis, Peritonitis, Tuberculous / diagnosis, Case Reports, Diagnosis, Differential, Female, Humans

Peritoneal tuberculosis is a rare form of tuberculosis which gives a non-specific clinical picture which can be confused with several digestive pathologies. It can also mimic ovarian cancer at the stage of peritoneal carcinomatosis, hence the interest sometimes of a diagnostic laparoscopy which makes it possible to make the diagnosis which is confirmed by an anatomo-pathological study. This is the case of our patient who was initially diagnosed with ovarian cancer and the diagnosis was corrected in peritoneal tuberculosis after a laparoscopy.
Carbonic anhydrase inhibitors limit complications in X-linked retinoschisis
Authors: Stephanie Wey, Daniel A Brill, Virginia Miraldi Utz, Robert A Sisk
Journal: Front Med (Lausanne) (2023)
Keywords: x-linked retinoschisis, acetazolamide, carbonic anhydrase inhibitors, dorzolamide, juvenile x-linked retinoschisis

Purpose:
Carbonic anhydrase inhibitors (CAIs) reduce macular schisis in patients with X-linked retinoschisis (XLRS). The purpose of this study was to determine if CAIs reduce the incidence of complications from XLRS, including macular atrophy, retinal tears, and retinal detachment (RD), the most common causes of vision loss in patients with XLRS.
Methods:
For this retrospective interventional case series, a chart review of patients examined at Cincinnati Children's Hospital Medical Center [CCHMC] and Cincinnati Eye Institute [CEI] between 1/1/2015 and 1/16/2023 was performed. Male patients were included based on genetically-confirmed RS1 or typical clinical presentation with known family history of XLRS with at least two follow-up visits.
Results:
Twenty-eight patients (56 eyes) with XLRS were included. There were 10 RS1 variants among the 21 genotyped patients. Median age at clinical diagnosis was 10.4 years old (range: 0.4-55.7 years) with median follow-up time of 4.7 years (range: 0.2-38.3 years). Median presenting Snellen visual acuity was 20/60 (logMAR 0.48, range: 0.18-3). In 26 eyes of 15 patients treated with CAIs, median CST pre-treatment was 416 microns (range: 198-701 microns), and median percentage decrease in CST on treatment was 21.8% (range: 0-74.5%) from highest pre-treatment CST. Reduction in CST with CAI use was statistically significant (p = 0.02), but not logMAR VA (p = 0.64). There was no significant difference in CST between patients treated with topical vs. oral CAI (p = 0.95) or between patients with partial or complete CAI adherence (p = 0.60). Ten eyes of seven patients had an RD requiring surgical intervention. No treated eyes developed new macular atrophy, peripheral retinoschisis, retinal tears, or RD; two eyes on topical CAIs had spontaneous resolution of bullous peripheral retinoschisis.
Conclusion:
During the follow-up period, patients taking CAIs reduced macular schisis and did not experience new complications of macular atrophy, retinal tears, or RD. This is a relatively large cohort with long-term follow-up periods for patients with XLRS. Reduced macular schisis may not require perfect adherence with CAIs. A large, prospective, randomized, controlled clinical trial is needed to determine the potential of CAIs to improve visual function, reduce retinoschisis, and prevent RD.
Understanding women's suffering and psychological well-being: exploring biopsychosocial factors in mothers of children with ADHD - a case study
Authors: Jonah Angeline, Maya Rathnasabapathy
Journal: Front Public Health (2023)
Keywords: adhd, mothers, parenting stress, psychological well-being, sufferings of women, women violence
MeSH terms: Attention Deficit Disorder with Hyperactivity / diagnosis, Attention Deficit Disorder with Hyperactivity / psychology, Child, Female, Humans, Parenting / psychology, Parents / psychology, Psychological Well-Being, Stress, Psychological / psychology

Overview:
Parents play a dynamic part in child development. Mothers have a great responsibility towards the upbringing child. Previous research has demonstrated that parenting stress levels are high among Parents of children with attention deficit hyperactivity disorder (ADHD).
Aim:
Parenting stress affects the psychological well-being of the mother. It is necessary to identify the factors that affect psychological well-being based on Biopsychosocial factors, including biological, psychological, and social factors.
Methodology:
An in-depth case study was conducted with the mother of a 7-year-old child diagnosed with attention deficit hyperactivity disorder.
Results:
The mother lacks self-efficacy and low perceived social support in. Equipping themselves and building up the knowledge on handling the child and training the child with the developmental disorder increase parenting self-efficacy. Support from family, partner, and society will help them strengthen themselves and may have high psychological support.
Acute macular neuroretinopathy and COVID-19 or SARS-CoV-2 infection: case report and literature review
Authors: Xing Wang, Peng Wang, Jing Lu, Huan Ju, Hao Xie, Hui Peng
Journal: Front Med (Lausanne) (2024)
Keywords: covid-19, sars-cov-2, acute macular neuroretinopathy, corticosteroids, paracentral scotomas
MeSH terms: Case Reports

Purpose:
To describe a case of acute macular neuroretinopathy (AMN) associated with COVID-19 infection and a related literature review.
Methods:
A case from the First Affiliated Hospital of Chongqing Medical University was reported that could be linked to COVID-19 or SARS-CoV-2 infection. We performed a comprehensive search on PubMed, retrieving articles containing information on AMN after COVID-19 or SARS-CoV-2 infection. The key words used were 'COVID-19', 'SARS-CoV-2', 'ophthalmic manifestations', 'acute macular neuroretinopathy', and 'paracentral scotomas'. The relevant data were extracted, charted, consolidated, and evaluated. Moreover, manual exploration of the reference lists of pertinent articles was carried out.
Results:
We describe the case of a 30-year-old young woman who developed bilateral AMN one day after being infected with COVID-19 or SARS-CoV-2. She had severe visual impairment (20/2000 OD and 20/32 OS), and her vision recovered after taking oral corticosteroids. After reviewing the literature, we summarized 16 relevant reports and found that symptoms of AMN tend to arise 1 day to 1 month after COVID-19 or SARS-CoV-2 infection. Contraceptive pills and other risk factors should be avoided to reduce the risk of adverse outcomes. Oral prednisone may be an effective treatment for those experiencing important vision loss.
Conclusion:
Symptoms of AMN can arise 1 day to 1 month after COVID-19 or SARS-CoV-2 infection. Ophthalmologists should remain vigilant about this disease, notably because patient characteristics may deviate from the norm.