OpenMed/multicare-articles huggingface dataset:
Salvage Therapy With Polatuzumab Vedotin, Bendamustine, and Rituximab Prior to Allogeneic Hematopoietic Transplantation in Patients With Aggressive Lymphomas Relapsing After Therapy With Chimeric Antigen Receptor T-Cells-Report on Two Cases
Authors: Kristin Gerhardt, Madlen Jentzsch, Thomas Georgi, Aleksandra Sretenović, Michael Cross, Enrica Bach, Astrid Monecke, Sabine Leiblein, Sandra Hoffmann, Milena Todorović, Jelena Bila, Osama Sabri, Sebastian Schwind, Georg-Nikolaus Franke, Uwe Platzbecker, Vladan Vučinić
Journal: Front Oncol (2021)
Keywords: car (chimeric antigen receptor) t cells, dlbcl, pmbcl, allogeneic hematopoeitic stem cell transplantation, polatuzumab vedotin
MeSH terms: Case Reports

Up to 60% of patients with aggressive B-cell lymphoma who receive chimeric antigen receptor (CAR) T-cell therapy experience treatment failure and subsequently have a poor prognosis. Allogeneic hematopoietic stem cell transplantation (alloHSCT) remains a potentially curative approach for patients in this situation. Induction of a deep response prior to alloHSCT is crucial for long-term outcomes, but the optimal bridging strategy following relapse after CAR T-cell therapy has not yet been established. Polatuzumab vedotin, an antibody drug conjugate targeting CD79b, is a novel treatment option for use in combination with rituximab and bendamustine (Pola-BR) in relapsed or refractory disease. Patients: We report two heavily pretreated patients with primary refractory diffuse large B-cell lymphoma (DLBCL) and primary mediastinal B-cell lymphoma (PMBCL) respectively who relapsed after therapy with CAR T-cells with both nodal and extranodal manifestations of the disease. After application of three courses of Pola-BR both patients achieved a complete metabolic remission. Both patients underwent alloHSCT from a human leukocyte antigen (HLA)-mismatched donor following conditioning with busulfan and fludarabine and are disease free 362 days and 195 days after alloHSCT respectively. We conclude that Pola-BR can be an effective bridging therapy before alloHSCT of patients relapsing after CAR T-cell therapy. Further studies will be necessary to define the depth and durability of remission of this salvage regimen before alloHSCT.
Report of a patient with a de novo non-recurrent duplication of 17p11.2p12 and Yq11 deletion
Authors: Liliana Fernández-Hernández, María José Navarro-Cobos, Miguel Angel Alcántara-Ortigoza, Sandra Elena Ramos-Ángeles, Bertha Molina-Álvarez, Sinhué Díaz-Cuéllar, Bárbara Asch-Daich, Ariadna González-Del Angel
Journal: Mol Cytogenet (2019)
Keywords: chromosomal microarray analysis, concurrent de novo rearrangements, duplication of 17p112p12, non-recurrent rearrangements, yq11 deletion
MeSH terms: Case Reports

Background:
The 17p11.2p12 locus is an unstable region that is predisposed to several known genomic disorders and non-recurrent rearrangements that yield varied and wide-ranging phenotypes. Nearly 1% of male newborns have deletions in the Y chromosome; these events primarily involve the heterochromatic region, but may extend to euchromatic Yq segments containing azoospermia factor regions.
Case presentation:
We describe the occurrence of two independent chromosomal rearrangements that originated as de novo events in a single male patient: a 10.8-Mb duplication of 17p11.2p12 and a 14.7-Mb deletion of Yq11. This individual shares some clinical characteristics with previously described patients having one or the other of these rearrangements, including global developmental delay, short stature, hypotonia, delayed puberty, certain facial features and a generalized demyelinating sensory-motor polyneuropathy without clinical manifestation. Our patient also presents some features that were not previously described in relevant individuals, including camptodactyly, preauricular pits and hypertrichosis of the back and elbows.
Conclusions:
To our knowledge, this is the first patient to be reported with independent de novo deletion/duplication events involving chromosomes 17 and Y. We discuss possible responsible mechanisms and address the phenotype, particularly in light of the clinical features that were not previously reported for patients bearing a duplication of 17p11.2p12 or a deletion of Yq11. We suggest that some of the previously reported patients with Yq11 deletion and clinical manifestations other than male infertility may have additional chromosomal imbalances that could be identified by chromosome microarray analysis, as illustrated by the present case.
Case Report: Identification of Maternal Low-Level Mosaicism in the Dystrophin Gene by Droplet Digital Polymerase Chain Reaction
Authors: Pengzhen Jin, Xiaoyang Gao, Miaomiao Wang, Yeqing Qian, Jingjin Yang, Yanmei Yang, Yuqing Xu, Yanfei Xu, Minyue Dong
Journal: Front Genet (2021)
Keywords: duchenne muscular dystrophy, de novo mutations, droplet digital polymerase chain reaction, gap-polymerase chain reaction, germline mosaicism
MeSH terms: Case Reports

Germline mosaicism should be suspected when the same de novo mutations are identified in a second pregnancy with asymptomatic parents. Our study aims to find a feasible approach to reveal the existence of germline mosaicism. Multiplex Ligation-dependent Probe Amplification was performed on a Duchenne muscular dystrophy affected pedigree to detect deletion mutations. Then gap-polymerase chain reaction was performed to amplify the breakpoints junction sequence. Droplet digital polymerase chain reaction was utilized to identify the mutation frequencies in healthy parents. The same deletion in the exon 51 of the dystrophin gene, which was 50,035 bp in size, was detected in the proband and the fetus but not in their parents. Droplet digital polymerase chain reaction analysis of peripheral blood samples revealed mutant alleles of 3.53% in maternal blood cells. We here report a case of maternal low-level mosaicism confirmed by droplet digital polymerase chain reaction in peripheral blood samples, which reveals the existence of germline mosaicism. Gap-polymerase chain reaction combined with droplet digital polymerase chain reaction provide insights into the detection of germline mosaicism.
Acute pancreatitis induced by mycophenolate mofetil in a kidney transplant patient
Authors: Behzad Einollahi, Fardin Dolatimehr
Journal: J Nephropharmacol (2015)
Keywords: acute pancreatitis, kidney transplantation, mycophenolate mofetil
MeSH terms: Case Reports

Acute pancreatitis is a rare life-threatening complication in patients after kidney transplantation. Here we described a 56-year-old man who had received a living related kidney transplant for an end-stage renal disease. In his regular follow-up, his serum creatinine was gradually increased and he underwent an allograft biopsy, which revealed an interstitial nephritis/tubular atrophy grade II. Mycophenolate mofetil (MMF) was prescribed to control chronic allograft nephropathy. He presented with complaints of severe abdominal pain, vomiting, loss of appetite and fever requiring hospital admission twelve days later. Acute pancreatitis was diagnosed on the basis of laboratory data and imaging findings during hospital admission. There was no history of alcohol consumption in our patient. Unfortunately he died one week later and autopsy findings demonstrated acute necrotizing pancreatitis. The bladder drainage of this patients was normal. Laboratory findings in this patient did not endorse infections and other possibilities regarding the etiology of acute pancreatitis in this patient. Therefore, we concluded that acute pancreatitis in near the patient was induced by drugs and basis on our evidence, MMF is the most important suspect. This study suggests that acute pancreatitis can be considered as a side effect of MMF.
Case Report: Minimally Invasive Therapy by Transcatheter Aortic Valve Replacement and Percutaneous Intramyocardial Septal Radiofrequency Ablation for a Patient With Aortic Stenosis Combined With Hypertrophic Obstructive Cardiomyopathy: Two-Year Follow-Up Results
Authors: Yijian Li, Yuan Feng, Xi Li, Lei Zuo, Tao Gu, Liwen Liu, Mao Chen
Journal: Front Cardiovasc Med (2021)
Keywords: aortic valve stenosis, hypertrophic obstructive cardiaomyopathy, minimally invasive therapy, percutaneous intramyocardial septal radiofrequency ablation, transcatheter aortic valve replacement
MeSH terms: Case Reports

With the development of minimally invasive technologies in the medical field, more and more technologies can replace surgical thoracotomy and relieve the pain of disease via minimally invasive methods. We reported a case of aortic valve stenosis combined with left ventricular outflow track obstruction treated by two minimally invasive techniques, transcatheter aortic valve replacement and transthoracic echocardiography-guided percutaneous intramyocardial septal radiofrequency ablation, and followed up for 2 years.
Eustachian valve endocarditis: a rare localization of right side endocarditis. A case report and review of the literature
Authors: Adriano M Pellicelli, Paolo Pino, Antonio Terranova, Cecilia D'Ambrosio, Fabrizio Soccorsi
Journal: Cardiovasc Ultrasound (2005)
MeSH terms: Endocarditis / diagnostic imaging, Endocarditis / microbiology, Staphylococcal Infections / diagnostic imaging, Staphylococcal Infections / microbiology, Substance Abuse, Intravenous / microbiology, Vena Cava, Inferior / diagnostic imaging, Vena Cava, Inferior / microbiology, Case Reports, Review, Adult, Endocarditis / etiology, Female, Humans, Rare Diseases / diagnostic imaging, Ultrasonography

Background:
Right-sided endocarditis occurs predominantly in intravenous drug users, in patients with pacemaker or central venous lines and in patients with congenital heart disease. The vast majority of cases involve the tricuspid valve. Eustachian valve endocarditis is an uncommon disease with similar signs and symptoms of the tricuspid valve endocarditis. A series of only 16 cases of eustachian valve endocarditis are reported in the literature.
Case presentation:
We present a case of a 25-year old woman with intravenous drug abuse who had a staphylococcus aureus tricuspid valve endocarditis associated to eustachian valve endocarditis. Transthoracic echocardiography, as first line examination, showed the vegetations on tricuspid and eustachian valve.
Conclusion:
Our case describe an unusual location of right side endocarditis in a intravenous drug abuser. In our case, in accord with other cases described in the literature, transthoracic echocardiography disclosed eustachian valve endocarditis. Antimicrobial management is not altered by the recognition of eustachian valve endocarditis. Antibiotic treatment and duration of eustachian endocarditis depends on the isolated organism and is similar to antibiotic therapy used in native valve endocarditis.
Rituximab administration in third trimester of pregnancy suppresses neonatal B-cell development
Authors: D T Klink, R M van Elburg, M W J Schreurs, G T J van Well
Journal: Clin Dev Immunol (2008)
MeSH terms: Antibodies, Monoclonal / therapeutic use, B-Lymphocytes / immunology, Immunologic Factors / therapeutic use, Pregnancy Complications, Hematologic / drug therapy, Purpura, Thrombocytopenic, Idiopathic / drug therapy, Case Reports, Adult, Antibodies, Monoclonal / administration & dosage, Antibodies, Monoclonal / adverse effects, Antibodies, Monoclonal / immunology, Antibodies, Monoclonal, Murine-Derived, Antigens, CD20 / immunology, B-Lymphocytes / metabolism, Female, Humans, Immunologic Factors / administration & dosage, Immunologic Factors / adverse effects, Immunologic Factors / immunology, Infant, Newborn, Pregnancy, Pregnancy Complications, Hematologic / immunology, Pregnancy Trimester, Third, Purpura, Thrombocytopenic, Idiopathic / immunology, Rituximab, Antibodies, Monoclonal, Antibodies, Monoclonal, Murine-Derived, Antigens, CD20, Immunologic Factors, Rituximab

We describe the effect on the neonate of administration of rituximab to a woman with idiopathic thrombocytopenic purpura (ITP). Rituximab, an anti-CD20 antibody, was given weekly for 4 weeks to a woman with ITP in her third trimester of pregnancy. One month after the last rituximab administration a healthy girl was born. She had normal growth and development during the first six months. At birth, B-lymphocytes were not detectable. Rituximab levels in mother and neonate were 24000 and 6700 ng/mL, respectively. Only 7 cases of rituximab administration during pregnancy were described. No adverse events are described for fetus and neonate. We demonstrate that rituximab passes the placenta and inhibits neonatal B-lymphocyte development. However, after 6 months B-lymphocyte levels normalized and vaccination titres after 10 months were adequate. No infection-related complications occurred. Rituximab administration during pregnancy appears to be safe for the child but further studies are warranted.
Nontypeable Haemophilus influenzae Otitis Media: Mastoiditis and Meningitis Complicated with Central Venous Thrombosis in an Immunocompetent Child
Authors: Erdem Gönüllü, Nesrin Özkan, Ahmet Soysal, Engin Acıoğlu, Emine Betül Tavil, Selin Nar Ötgün, Metin Karaböcüoğlu
Journal: Case Rep Infect Dis (2021)
MeSH terms: Case Reports

Implementation of the Haemophilus influenzae type B (Hib) conjugate vaccine brought about a reduction in the number of cases and morbidity from type B but an increase in nontypeable strain infections. Nontypeable Haemophilus influenzae (NTHi) commonly colonizes children's upper respiratory tract and causes otitis media, sinusitis, and bronchitis. Invasive NTHi diseases, such as meningitis and septicemia, have rarely been reported. Herein, we discuss a previously healthy, fully immunized 3-year-old girl presented with otitis media and mastoiditis leading to meningitis caused by NTHi complicated with central venous thrombosis. She was treated with antibiotics, mastoidectomy and ventilation tube insertion, and anticoagulation therapy and recovered uneventfully. Through this case, we wish to share our unique clinical experience that NTHi should be born in mind as a potential pathogen that can cause meningitis in previously healthy children, which may be helpful in future cases.
Case Report: The Complexities of Managing Medications and the Importance of Deprescribing Anticholinergics in Older Adults
Authors: Taylor Elliott, Lynne Eckmann, Daniela C Moga
Journal: Front Pharmacol (2021)
Keywords: anticholinergics, case report, deprescribing, medications, polypharmacy
MeSH terms: Case Reports

Potentially inappropriate anticholinergic medications (including over-the-counter products), polypharmacy, and the existence of communication barriers among members of the interprofessional team frequently contribute to clinical complexity in older adults. We present the case of a frail 86-year old female from the perspective of a community pharmacist managing outpatient medications and transitions of care. CD's past medical history is significant for dementia, multiple falls, recurrent urinary tract infections, depression, cardiac arrhythmia, macular degeneration, chronic pain, depression, and cerebrovascular disease.
Atypical Hepatic Hemangioma with Fluid-Fluid Level on CT and MRI: Emphasis on Added Value of Contrast-Enhanced Ultrasound Findings
Authors: Ye Rin Kim, Ji Eun Lee, Min Jung Jung
Journal: J Belg Soc Radiol (2022)
Keywords: computed tomography, contrast-enhanced ultrasonography, fluid-fluid level, hepatic hemangioma, magnetic resonance imaging
MeSH terms: Case Reports

We present an atypical case of a patient with hepatic hemangiomas showing fluid-fluid levels on computed tomography (CT) and magnetic resonance imaging (MRI). None of the lesions showed contrast enhancement, mimicking complicated hepatic cysts or metastasis with hemorrhagic content. On contrast-enhanced ultrasound the lesions showed peripheral nodular enhancement with complete fill-in on late phases, suggestive of hepatic hemangioma. Teaching point: Contrast-enhanced ultrasound (CE-US) may be useful in diagnosing atypical hepatic hemangioma showing fluid-fluid levels on computed tomography (CT) or magnetic resonance imaging (MRI).
Contrast-Enhanced Ultrasound of Primary Squamous Cell Carcinoma of the Thyroid: A Case Report
Authors: Sijie Chen, Qinghai Peng, Qi Zhang, Chengcheng Niu
Journal: Front Endocrinol (Lausanne) (2020)
Keywords: contrast enhanced ultrasound (ceus), primary squamous cell carcinoma, thyroid cancer, thyroid nodules (tns), thyroid ultrasound (us)
MeSH terms: Carcinoma, Squamous Cell / pathology, Contrast Media, Thyroid Neoplasms / pathology, Thyroid Nodule / pathology, Ultrasonography, Doppler, Color / methods, Case Reports, Research Support, Non-U.S. Gov't, Carcinoma, Squamous Cell / diagnostic imaging, Carcinoma, Squamous Cell / surgery, Humans, Male, Middle Aged, Prognosis, Thyroid Neoplasms / diagnostic imaging, Thyroid Neoplasms / surgery, Thyroid Nodule / diagnostic imaging, Thyroid Nodule / surgery, Thyroidectomy, Contrast Media

Introduction: Primary squamous cell carcinoma of the thyroid (ThyPSCC) is an extremely rare aggressive malignancy with a poor prognosis. However, almost no report thus far has investigated the microvasculature of ThyPSCC imaged using contrast-enhanced ultrasound. Case Report: A 59-year-old male patient presented to our hospital with progressively worsening hoarse voice symptoms for 20 days and was diagnosed with left unilateral vocal fold palsy. Ultrasonography revealed a solitary marked hypoechoic thyroid nodule with an unclear boundary in the inferior part of the left lobe. Color Doppler flow imaging showed a poor blood flow signal inside this nodule. Contrast-enhanced ultrasound images showed a persistent low peak enhancement of the nodule from its periphery to its center. The time-intensity curve displayed a wash-in time of 10 s, a time to peak of 37 s, a peak signal intensity of 24.5%, and a wash-out time of 70 s for the thyroid tumor. Finally, left hemithyroidectomy of the thyroid tumor was performed, and histopathologic and immunohistochemical evaluations confirmed the diagnosis of ThyPSCC. Postoperatively, the patient received a combination therapy of chemotherapy, radiotherapy, and targeted therapy, but the patient died 4 months after surgery. Conclusion: Primary squamous cell carcinoma of the thyroid is a rare but aggressive malignancy of the thyroid. Herein, we reported a case of ThyPSCC and its ultrasonography and pathologic findings.
The Utility of Bronchoscopy in Hydralazine-Induced ANCA-Associated Vasculitis
Authors: Atulya Aman Khosla, Hollie Saunders, Scott Helgeson, Hiroshi Hikida, Nabeel Aslam, Fadi Salem, Sam Albadri, Hassan Baig
Journal: Case Rep Pulmonol (2023)
MeSH terms: Case Reports

Hydralazine is a vasodilator used for the management of hypertension, heart failure, and hypertensive emergencies in pregnancy. It has been implicated in the causation of drug-induced lupus erythematosus (DLE) and rarely with ANCA-associated vasculitis (AAV), which may present as a pulmonary-renal syndrome and be rapidly fatal. Herein, we describe a case of hydralazine-associated AAV presenting as acute kidney injury with the use of early bronchoalveolar lavage (BAL) with serial aliquots to aid with diagnosis. Our case highlights how, in the correct clinical setting, BAL can act as a rapid diagnostic test to help guide quicker treatment to allow for better patient outcomes.
Pregnancy in a woman undergoing peritoneal dialysis: Management and dialysis options
Authors: Rita Veríssimo, Estela Nogueira, João Bernardo, Marta Pereira, Cristina P Abreu, Noelia Lopez, Cristina Resina, Patrícia Matias, José António Lopes, Patrícia Branco, Luísa Pinto
Journal: Clin Nephrol Case Stud (2022)
Keywords: dialysis dose, end-stage renal disease, peritoneal dialysis, pregnancy
MeSH terms: Case Reports

Pregnancy in patients with end-stage renal disease on maintenance dialysis is uncommon, with annual incidences reported at 0.3 - 2.7%. Peritoneal dialysis usage in pregnancy has been less reported than hemodialysis, although outcomes are similar. Nowadays, there are insufficient data to establish a generalizable dialysis strategy in pregnant women with end-stage renal disease. As such, decisions should be individualized, depending on clinical factors, residual renal function, and, whenever possible, choice of the patient. We report the case of a 22-year-old patient receiving peritoneal dialysis who delivered a full-term, normal weight, healthy baby with increased dialysis dose achieved by supplementary hemodialysis during pregnancy, thus enabling peritoneal dialysis to be continued until the third trimester and minimizing hemodialysis requirements.
Case Report: Efficacy of Ninjin'yoeito Treatment for Idiopathic Pulmonary Fibrosis
Authors: Hisako Kushima, Hiroshi Ishii, Masaki Fujita
Journal: Front Nutr (2021)
Keywords: kampo medicine, idiopathic pulmonary fibrosis, loss of appetite, malaise, ninjin'yoeito
MeSH terms: Case Reports

Ninjin'yoeito, a Kampo prescription, was administered to two patients with idiopathic pulmonary fibrosis (IPF) over a period of 12 weeks to improve loss of appetite and lassitude. In Case 1, improvements were observed in appetite, lassitude, and breathlessness, as well as increases or increasing tendencies in body weight, blood albumin level, and hemoglobin (Hb) level. Case 2 showed no changes in appetite but improvements in lassitude and no deterioration of breathlessness. His body weight and his blood albumin and Hb levels increased or showed increasing trends. In both cases, a trend for improvement of respiratory function was observed. In summary, ninjin'yoeito trended to improve the subjective symptoms and nutritional status of a patient with pulmonary fibrosis.
Adult T-Cell Leukemia/Lymphoma with CLL-Like Morphology-A Case Report
Authors: Nishant Tageja, Mobayed Mohammad, Gail Bentley, Carter Bishop
Journal: Case Rep Med (2010)
MeSH terms: Case Reports

Adult T-cell Leukemia/Lymphoma (ATL) is rarely seen in the U.S. and Europe, usually limited to African Americans from the southeastern U.S. and immigrants from HTLV-1 endemic areas. Reaching an accurate and timely diagnosis of ATL in such nonendemic areas can be challenging, owing to limited exposure, diverse manifestations, and varying cell morphology. We present a case of chronic adult T-cell leukemia (ATL) with Chronic Lymphocytic Leukemia- (CLL-) like morphology that remained untreated for ten years and then developed treatment refractory acute ATL crisis.
Mesenteric Cyst: A Case Report of a Healthy, Five-Year-Old Patient
Authors: Pedro Sureda, Rafael Mena Canto, Carmen L Familia Sanchez
Journal: Cureus (2023)
Keywords: abdominal mass, cyst, mesentery, pediatrics, surgery
MeSH terms: Case Reports

Mesenteric and omental cysts can be seen at any age, with one in three cases seen in patients under 15 years old. These cysts represent one in 20,000 pediatric admissions. Here we share the case of a five-year-old female patient at a health center in a developing country, with the purpose of contributing to documentation in the region.