OpenMed/multicare-articles huggingface dataset:
Yersinia pseudotuberculosis bacteraemia with splenic abscesses: a case report
Authors: Rahel Tefera Zewude, Aleksandra Stefanovic, Zersenay Alem
Journal: Access Microbiol (2023)
Keywords: yersinia, bacteraemia, pseudotuberculosis, splenic abscesses
MeSH terms: Case Reports

Introduction:

Yersinia pseudotuberculosis has been known to cause a variety of clinical manifestations ranging from mild enteric illness to bacteraemia with septic shock and extraintestinal abscesses. Patients with liver disease and iron overload are at risk of more severe disease manifestations.
Case report:
A middle-aged male with chronic alcohol use disorder presented with confusion and jaundice, with ascites and asterixis noted on examination. His blood work was remarkable for neutrophilic leukocytosis, elevated liver enzymes and lactate. An abdominal computed tomography scan revealed splenic microabscesses and a cirrhotic liver. Yersinia pseudotuberculosis was recovered from his blood cultures and he was treated with ceftriaxone following susceptibility results.
Conclusion:

Y. pseudotuberculosis should be considered in the differential diagnosis of splenic or other extraintestinal microabscesses particularly in patients with chronic liver disease.
Pseudomyxoma Peritonei in a Case of Carcinoma Cervix: Subtle Finding With Implications on Management and Prognosis
Authors: Sarita Kumari, Suvidya Singh
Journal: Case Rep Oncol Med (2024)
Keywords: adenocarcinoma, carcinoma cervix, pseudomyxoma peritonei
MeSH terms: Case Reports

Pseudomyxoma peritonei (PMP) is a well-known entity in gastrointestinal and ovarian tumors of mucinous histology. It has important implications on prognosis depending on whether seen in conjunction with a benign or a malignant tumor. In the current report, we describe a case of PMP in a case of advanced endocervical adenocarcinoma of the cervix which was managed surgically.
Endovascular Thrombectomy for Radial Artery Occlusion in Neuro-Interventional Procedures: A Report of Two Cases
Authors: Travis Atchley, Philip Schmalz
Journal: Cureus (2024)
Keywords: case report, endovascular thrombectomy, mechanical thrombectomy, radial artery access, radial artery occlusion
MeSH terms: Case Reports

Transradial access has garnered increasing popularity and acceptance among the neuro-interventional community. As this technique becomes commonplace for both diagnostic and interventional procedures, an understanding of potential complications and management is tantamount. Here, we describe two cases of thrombosed radial arteries successfully recanalized with traditional thrombectomy techniques. Two patients presented with aneurysmal subarachnoid hemorrhage and were found to have ruptured anterior communicating artery aneurysms. Both patients were deemed appropriate candidates for endovascular treatment. During attempted access, both patients were found to have occluded right radial arteries due to previous arterial access, one from a prior intervention and one from an arterial line placed at another facility. Thrombectomies were subsequently performed, one via manual aspiration through the access sheath and the other with a commercially available aspiration system. Both radial arteries were successfully recanalized and the interventions were completed via transradial access. Endovascular thrombectomy for radial artery thrombosis is a feasible and simple technique that can be employed to facilitate transradial access for neuro-endovascular procedures when a thrombosed radial artery is encountered. This technique can be attempted in cases of radial artery thrombosis prior to conversion to transfemoral access.
Cerebrospinal fluid oligoclonal bands in Chinese patients with multiple sclerosis: the prevalence and its association with clinical features
Authors: Xiang Zhang, Hongjun Hao, Tao Jin, Wei Qiu, Huan Yang, Qun Xue, Jian Yin, Ziyan Shi, Hai Yu, Xiaopei Ji, Xiaobo Sun, Qiuming Zeng, Xiaoni Liu, Jingguo Wang, Huining Li, Xiaoyan He, Jing Yang, Yarong Li, Shuangshuang Liu, Alexander Y Lau, Feng Gao, Shimin Hu, Shuguang Chu, Ding Ding, Hongyu Zhou, Haifeng Li, Xiangjun Chen
Journal: Front Immunol (2023)
Keywords: china, cerebrospinal fluid, diagnostic performance, multiple sclerosis, oligoclonal bands, prevalence
MeSH terms: Multiple Sclerosis / diagnosis, Multiple Sclerosis / epidemiology, Multicenter Study, Research Support, Non-U.S. Gov't, East Asian People, Humans, Oligoclonal Bands / cerebrospinal fluid, Prevalence, Prospective Studies, Retrospective Studies, Oligoclonal Bands

Background:
Cerebrospinal fluid oligoclonal band (CSF-OCB) is an established biomarker in diagnosing multiple sclerosis (MS), however, there are no nationwide data on CSF-OCB prevalence and its diagnostic performance in Chinese MS patients, especially in the virtue of common standard operation procedure (SOP).
Methods:
With a consensus SOP and the same isoelectric focusing system, we conducted a nationwide multi-center study on OCB status in consecutively, and recruited 483 MS patients and 880 non-MS patients, including neuro-inflammatory diseases (NID, n = 595) and non-inflammatory neurological diseases (NIND, n=285). Using a standardized case report form (CRF) to collect the clinical, radiological, immunological, and CSF data, we explored the association of CSF-OCB positivity with patient characters and the diagnostic performance of CSF-OCB in Chinese MS patients. Prospective source data collection, and retrospective data acquisition and statistical data analysis were used.
Findings:
369 (76.4%) MS patients were OCB-positive, while 109 NID patients (18.3%) and 6 NIND patients (2.1%) were OCB-positive, respectively. Time from symptom onset to diagnosis was significantly shorter in OCB-positive than that in OCB-negative MS patients (13.2 vs 23.7 months, P=0.020). The prevalence of CSF-OCB in Chinese MS patients was significantly higher in high-latitude regions (41°-50°N)(P=0.016), and at high altitudes (>1000m)(P=0.025). The diagnostic performance of CSF-OCB differentiating MS from non-MS patients yielded a sensitivity of 76%, a specificity of 87%.
Interpretation:
The nationwide prevalence of CSF-OCB was 76.4% in Chinese MS patients, and demonstrated a good diagnostic performance in differentiating MS from other CNS diseases. The CSF-OCB prevalence showed a correlation with high latitude and altitude in Chinese MS patients.
Case report: Endobronchial closure of postoperative bronchopleural fistula with embolization coil: a sandwich-like approach
Authors: Yang Bai, Jing Chi, Hansheng Wang, Yishi Li, Shuliang Guo
Journal: Front Med (Lausanne) (2024)
Keywords: embolization coil, bronchopleural fistula, bronchoscopic treatment, case series, interventional pulmonary
MeSH terms: Case Reports

Background:
Embolization Coil has been reported to effectively treat postoperative bronchopleural fistula (BPF). Little detailed information was available on computer tomography (CT) imaging features of postoperative BPF and treating procedures with pushable Embolization Coil.
Objective:
We aimed to specify the imaging characteristics of postoperative BPFs and present our experience treating them with the pushable Embolization Coil.
Methods:
Six consecutive patients (four males and two females aged 29-56 years) diagnosed with postoperative BPF receiving bronchoscopic treatment with the pushable Nester® Embolization Coil (Cook Medical, Bloomington, Indiana) were included in this single-center, retrospective study. Multiplanar reconstruction of multidetector CT scans was reviewed for the presence, location, size, and radiological complications of each BPF, including air collection, pneumothorax, bronchiectasis, and chest tube. Using standardized data abstraction forms, demographic traits and clinical outcomes were extracted from the medical files of these patients.
Results:
The underlying diseases for lung resection surgery were pulmonary tuberculosis (n = 3), lung adenocarcinoma (n = 2), and pulmonary aspergillosis (n = 1). All patients had air or air-fluid collection with chest tubes on radiological findings. Multiplanar reconstruction identified the presence of postoperative BPF in all patients. Five fistulas were central, located proximal to the main or lobar bronchus, while one was peripheral, distant from the lobar bronchus. Fistula sizes ranged from 0.8 to 5.8 mm. Subsequent bronchoscopy and occlusion testing confirmed fistula openings in the bronchial stump: right main bronchus (n = 1), right upper lobe (n = 2), and left upper lobe (n = 3). The angioplasty catheter-based procedure allows precise fistula occlusion "like a sandwich" with the pushable Embolization Coil. Five patients with BPF sizes ranging from 0.8 to 1.5 mm were successfully treated with a pushable Embolization Coil, except for one with a BPF size of 5.8 mm. No adverse events or complications were observed throughout follow-up, ranging from 29 to 1,307 days.
Conclusion:
The pushable Nester® Embolization Coil seems a minimally invasive, cost-effective, and relatively easy-to-perform bronchoscopic treatment for postoperative BPF with a size less than 2 mm. Further studies are required to ensure the use of pushable Embolization Coil in treating postoperative BPF.
Case report: A severe case of zoledronate-associated diffuse orbital inflammation and uveitis in a patient with metastatic breast cancer
Authors: Pushpinder Kanda, Isaura Guerrero-Córdova, Jobanpreet Dhillon, Adrian Tsang
Journal: Front Ophthalmol (Lausanne) (2024)
Keywords: bisphosphonates, drug-induced ocular inflammation, orbital inflammation, scleritis, uveitis, zoledronate
MeSH terms: Case Reports

Introduction:
Zoledronate is a commonly prescribed medication to maintain bone health; however, a rare side effect includes ocular inflammation. We report a case of simultaneous anterior uveitis and orbital inflammation associated with zoledronate infusion in a patient with metastatic breast cancer. We also performed a literature search to provide an up-to-date summary of cases with zoledronate-associated ocular inflammation.
Methods:
This is a case report with literature review. Literature search (timeline 2010 to 2023) was performed using PubMed with the search team: (zoledronate) AND (uveitis OR scleritis OR orbital inflammation OR ocular inflammation).
Results:
A 48-year-old female presented with left eye pain, swelling, and decreased vision 2 days after receiving zoledronic acid infusion. An ophthalmic exam showed non-granulomatous anterior uveitis. CT orbits and ocular ultrasound showed signs of posterior scleritis and orbital inflammation. Ocular inflammation caused by an infection or metastatic cancer was ruled out. The patient was treated with both topical and systemic corticosteroids. Complete resolution of the inflammation occurred after 2.5 weeks.
Conclusion:
Orbital inflammation and uveitis are an uncommon side effect of zoledronate but needs to be promptly recognized and treated to prevent sight-threatening complications.
Case report: First report of potentially zoonotic Gongylonema pulchrum in a free-living roe deer (Capreolus capreolus) in Slovenia
Authors: Petra Bandelj, Diana Žele Vengušt, Gorazd Vengušt, Darja Kušar
Journal: Front Vet Sci (2024)
Keywords: gongylonema pulchrum, pcr, nematode, oesophagus, roe deer (capreolus capreolus), sequencing, zoonosis
MeSH terms: Case Reports

Adult female and male Gongylonema nematodes were found in the oesophagus of a free-living roe deer (Capreolus capreolus) in Slovenia during passive health surveillance of wildlife. The genus Gongylonema was determined by light microscopy based on the genus-specific cuticular bosses in the anterior part of the parasite. Molecular methods were used to confirm the species Gongylonema pulchrum, which has zoonotic potential. Although Gongylonema species are considered common and distributed worldwide, this is the first report of G. pulchrum in an animal on the territory of Slovenia and the first molecular report in a roe deer worldwide. The parasite is likely to be underdiagnosed, misdiagnosed or goes unnoticed as the animals show little or no clinical signs and minor pathological lesions. Slaughterhouse workers, hunters and veterinarians should be aware of this elusive parasite. Examination and evisceration of the upper digestive tract of animals should therefore be carried out more carefully.
Lower limb preservation in pediatric trauma: a case study of Gustilo grade IIIC fracture in a 7-year-old
Authors: Jamal Ataya, Rawan Daaboul, Hassan Alhomsi, Hassan Issa, Ahmad Elewee
Journal: J Surg Case Rep (2024)
Keywords: gustilo grade iiic, case report, crush injury, internal fixation, limb salvage
MeSH terms: Case Reports

This case report describes the intricate aspects of managing pediatric lower limb trauma. A 7-year-old patient had a severe compound fracture and significant soft tissue damage in the left lower limb, classified as Gustilo Grade IIIC. This necessitated the use of scoring systems such as the Mangled Extremity Severity Score and limb salvage index to assess the likelihood of limb preservation. Despite these high amputation risk indicators, a multidisciplinary approach has led to limb salvage surgery with internal fixation. Detailed postoperative monitoring revealed progressive recovery culminating in restored sensation, bone healing, and functional recovery. The discussion emphasizes the difficulties in deciding between limb salvage and amputation, stressing the importance of tailored care and cautious scoring system interpretation in pediatric cases. This conclusion advocates the prioritization of limb salvage in children owing to their unique healing capabilities while highlighting the need for further research to refine treatment protocols for pediatric lower limb trauma.
Rickettsia rickettsii and Rickettsia typhi in hospitalized children diagnosed with Pediatric Multisystemic Inflammatory Syndrome in Merida, Yucatan
Authors: Karla Dzul-Rosado, Dayana Guadalupe Lavín-Sánchez, Gerardo Álvarez Hernández, Salvador Gómez-Carro, Fernando I Puerto-Manzano
Journal: Braz J Infect Dis (2024)
Keywords: fever, inflammatory markers, mis-c, rickettsiosis
MeSH terms: COVID-19 / complications, Rickettsia rickettsii, Rickettsia typhi, Systemic Inflammatory Response Syndrome, Case Reports, Child, Child, Hospitalized, Fever, Humans, Mexico, Pandemics, pediatric multisystem inflammatory disease, COVID-19 related

Multisystem Inflammatory Syndrome in Children (MIS-C) presents with fever, fatigue, elevated inflammatory markers (acute phase reactants), and a history of exposure to SARS-CoV-2 or positive antibodies to SARS-CoV-2. As the COVID-19 pandemic unfolded, the risk of MIS-C in the pediatric population increased. However, exposure to other viruses and the presence of SARS-CoV-2 positive antibodies in children hospitalized for various pathogen-associated illnesses will also remain common and may complicate differential diagnoses with diseases endemic to the region such as rickettsial diseases. The objective was to highlight the desirability of medical personnel systematically incorporating rickettsiosis as a differential diagnosis for MIS-C when studying a child with fever, non-specific symptoms, and elevated inflammatory markers. In conclusion MIS-C should be considered in children with elevated inflammatory markers when there is a history of COVID-19 and they also meet criteria that have already been established by international agencies, such as CDC and WHO.
Clinical pharmacist interventions in the transition of care in a mental health hospital: case reports focused on the medication reconciliation process
Authors: Matej Stuhec, Borjanka Batinic
Journal: Front Psychiatry (2023)
Keywords: case report, hospital clinical pharmacist in psychiatry, medication reconciliation, psychiatry, transition of care
MeSH terms: Case Reports

The transition of care represents a key point in the hospital admission and discharge process. A comprehensive transition could lead to fewer medication-related problems. The hospital clinical pharmacist could help in the transition of care process with a comprehensive medication reconciliation process, which has been poorly described in mental health hospitals. This study presents two clinical cases in which hospital clinical pharmacists identified omitted medications and other medication-related issues, including medication errors, during the transition of care in a mental health hospital. These positive experiences may encourage other countries to establish similar collaborations with hospital clinical pharmacists in mental health hospitals.
Multiple myeloma and Chagas disease: qPCR as a marker for preemptive antiparasitic therapy: a case reports series and review
Authors: Noemia Barbosa Carvalho, Vera Lúcia Teixeira de Freitas, Fernanda Salles Seguro, Rita Cristina Bezerra, Giancarlo Fatobene, Érika Yoshie Shimoda Nakanishi, Helena Visnadi, Gracia Martinez, Marjorie Vieira Batista, Vanderson Rocha, Frederico Luis Dulley, Sílvia Figueiredo Costa, Maria Aparecida Shikanai-Yasuda
Journal: Rev Inst Med Trop Sao Paulo (2024)
MeSH terms: Chagas Disease / drug therapy, Chagas Disease / epidemiology, Hematopoietic Stem Cell Transplantation, Multiple Myeloma / complications, Multiple Myeloma / drug therapy, Nitroimidazoles / therapeutic use, Trypanosoma cruzi, Case Reports, Antiparasitic Agents / therapeutic use, Humans, Parasitemia / drug therapy, Parasitemia / epidemiology, Parasitemia / parasitology, Prospective Studies, Transplantation, Autologous, Antiparasitic Agents, Nitroimidazoles

Multiple myeloma (MM) associated with Chagas disease is rarely described. This disease and its therapy suppress T cell and macrophage functions and increase regulatory T cell function, allowing the increase of parasitemia and the risk of Chagas Disease Reactivation (CDR). We aimed to analyze the role of conventional (cPCR) and quantitative Polymerase Chain Reaction (qPCR) for prospective monitoring of T. cruzi parasitemia, searching for markers of preemptive antiparasitic therapy in MM patients with Chagas disease. Moreover, we investigated the incidence and management of hematological diseases and CDR both inside and outside the transplant setting in the MEDLINE database. We found 293 studies and included 31 of them. Around 1.9-2.0% of patients with Chagas disease were reported in patients undergoing Stem Cell Transplantation. One case of CDR was described in eight cases of MM and Chagas disease. We monitored nine MM and Chagas disease patients, seven under Autologous Stem Cell Transplantation (ASCT), during 44.56±32.10 months (mean±SD) using parasitological methods, cPCR, and qPCR. From these patients, three had parasitemia. In the first, up to 256 par Eq/mL were detected, starting from 28 months after ASCT. The second patient dropped out and died soon after the detection of 161.0 par Eq/mL. The third patient had a positive blood culture. Benznidazole induced fast negativity in two cases; followed by notably lower levels in one of them. Increased T. cruzi parasitemia was related to the severity of the underlying disease. We recommend parasitemia monitoring by qPCR for early introduction of preemptive antiparasitic therapy to avoid CDR.
Retroperitoneal Peripancreatic Ganglioneuroma Encasing the Celiac Trunk and Superior Mesenteric Artery
Authors: Pablo Avila-Sanchez, Natalia M Barron-Cervantes, Alejandro Martinez-Esteban, Luis C Chan-Nuñez
Journal: Cureus (2024)
Keywords: celiac trunk, encasement, ganglioneuroma, peripancreatic, retroperitoneal, superior mesenteric artery
MeSH terms: Case Reports

A retroperitoneal ganglioneuroma is an exceptionally rare surgical entity, even more so in pancreaticoduodenal tumors. These well-differentiated neuroepithelial tumors originate in the neural crest, emerge in the sympathetic nervous system, and consist of ganglion cells and stromal Schwann cells. Generally, these tumors, despite being mostly benign, may be associated with venous or arterial vascular involvement. The symptomatology presented will depend on the mass effect due to tumor growth, and surgical excision is the only therapeutic option offered today to these patients. However, encapsulation of the main vessels represents a great surgical complexity. Various surgical approaches have been employed throughout history; however, the current preferred method is an open midline laparotomy, involving an extensive Kocher maneuver and an artery-first approach, aiming for an R0 resection of the tumor with total vascular preservation to the greatest extent possible. We present a case of an R2 resection involving a 95 mm x 85 mm retroperitoneal peripancreatic ganglioneuroma with double vascular involvement (celiac trunk and superior mesenteric artery). The procedure utilized an artery-first approach with total vascular preservation in a 17-year-old woman who had long-standing gastrointestinal symptoms due to the mass effect.
Case report: Longitudinal evaluation and treatment of a melanoma-associated retinopathy patient
Authors: Ryan M Mosavi-Hecht, Paul Yang, Barrett Heyer, Christopher R Rosenberg, Elizabeth White, Elizabeth G Berry, Robert M Duvoisin, Catherine W Morgans
Journal: Front Med (Lausanne) (2024)
Keywords: mar, trpm1, autoantibodies, autoimmune retinopathy, bipolar cells, melanoma, paraneoplastic syndrome, retina
MeSH terms: Case Reports

Melanoma-associated retinopathy (MAR) is a paraneoplastic syndrome associated with cutaneous metastatic melanoma in which patients develop vision deficits that include reduced night vision, poor contrast sensitivity, and photopsia. MAR is caused by autoantibodies targeting TRPM1, an ion channel found in melanocytes and retinal ON-bipolar cells (ON-BCs). The visual symptoms arise when TRPM1 autoantibodies enter ON-BCs and block the function of TRPM1, thus detection of TRPM1 autoantibodies in patient serum is a key criterion in diagnosing MAR. Electroretinograms are used to measure the impact of TRPM1 autoantibodies on ON-BC function and represent another important diagnostic tool for MAR. To date, MAR case reports have included one or both diagnostic components, but only for a single time point in the course of a patient's disease. Here, we report a case of MAR supported by longitudinal analysis of serum autoantibody detection, visual function, ocular inflammation, vascular integrity, and response to slow-release intraocular corticosteroids. Integrating these data with the patient's oncological and ophthalmological records reveals novel insights regarding MAR pathogenesis, progression, and treatment, which may inform new research and expand our collective understanding of the disease. In brief, we find TRPM1 autoantibodies can disrupt vision even when serum levels are barely detectable by western blot and immunohistochemistry; intraocular dexamethasone treatment alleviates MAR visual symptoms despite high levels of circulating TRPM1 autoantibodies, implicating antibody access to the retina as a key factor in MAR pathogenesis. Elevated inflammatory cytokine levels in the patient's eyes may be responsible for the observed damage to the blood-retinal barrier and subsequent entry of autoantibodies into the retina.