OpenMed/multicare-articles huggingface dataset:
Intravesical migration of an intrauterine device
Authors: Christian Kofi Gyasi-Sarpong, Patrick Opoku Manu Maison, Emmanuel Morhe, Ken Aboah, Kwaku Addai-Arhin Appiah, Roland Azorliade, Kofi Baah-Nyamekye, Kwaku Otu-Boateng, George Amoah, Isaac Antwi, Benjamin Frimpong-Twumasi, Douglas Arthur
Journal: BMC Res Notes (2016)
MeSH terms: Foreign-Body Migration / etiology, Intrauterine Devices / adverse effects, Urinary Bladder / pathology, Case Reports, Abdomen / diagnostic imaging, Adult, Female, Foreign-Body Migration / diagnostic imaging, Humans, Ultrasonography

Background:
Intrauterine contraceptive device is the most common method of reversible contraception in women. The intrauterine contraceptive device can perforate the uterus and can also migrate into pelvic or abdominal organs. Perforation of the urinary bladder by an intrauterine contraceptive device is not common. In West Africa, intravesical migration of an intrauterine contraceptive device has been rarely reported. In this report, we present a case of an intrauterine contraceptive device migration into the urinary bladder of a 33 year old African woman at the Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Case report:
A 33 year old African woman presented with persistent urinary tract infection of 7 months duration despite appropriate antibiotic treatments. An abdominal ultrasonography revealed a urinary bladder calculus which was found to be an intrauterine contraceptive device on removal at cystoscopy. She got pregnant whilst having the intrauterine contraceptive device in place and delivered at term.
Conclusion:
The presence of recurrent or persistent urinary tract infection in any woman with an intrauterine contraceptive device should raise the suspicion of intravesical migration of the intrauterine contraceptive device.
Liquid Silicone-Induced Extensive and Debilitating Granulomatosis Responding to Hydroxychloroquine
Authors: Nargis Jilani, Javeria Shabbir, Elena Nemytova
Journal: Case Rep Rheumatol (2019)
MeSH terms: Case Reports

In the last two decades, there has been a significant rise in body-image improvement among the American consumers. Cosmetic injectable procedures have increased by 40.6% in the past 5 years. There has also been an increase in nonmedical, illegal, and self-appointed personnel, offering cheaper hazardous procedures. Silicone has been in use since 1965. In 1991, FDA issued guidelines prohibiting the marketing of injectable liquid silicone. However, it is biologically inert, is associated with inflammatory response, and leads to serious complications like granulomatosis, migration, acute pneumonitis, pulmonary embolism, and even death. Here, we present a case of silicone-induced granulomatosis with extensive migration which ended in bilateral mastectomy, multiple anterior chest debulking procedures, and finally peg tube placement due to compression of the esophageal lumen by granulomas. The patient was eventually started on immunomodulatory treatment, hydroxychloroquine with good response.
Primary papilloma of the proximal ureter in a 13-year old boy: A rare case
Authors: Mahtab Rahbar, Keykhosro Mardanpour, Maryam Rahbar, Seyed Javad Nasiri
Journal: Int J Surg Case Rep (2020)
Keywords: child, papilloma, ureter
MeSH terms: Case Reports

Introduction:
Approximately 1 percent of the tumors observed in the upper urinary tract are primary tumors of the ureter. The exact diagnosis is done by a histologic study. Most cases need surgery, which is done by complete resection of the tumoral segment of the ureter.
Presentation of case:
This study presents a 13-year-old boy who referred to Ali Asghar pediatric hospital with complaints of right flank pain and hematuria for four months. The ultrasonography revealed moderate-grade hydronephrosis. The retrograde urography confirmed a 1.5 cm lesion with filling defects in the proximal segment of the right ureter. The abdominal CT-scan confirmed a 1.5 cm filling defect lesion with a smooth margin in the right proximal ureter adjacent to the ureteropelvic orifice. On cystoscopy, a sessile mass developed in the proximal portion of right ureter and providing pronounced dilation of the ureter and ipsilateral hydronephrosis. Histopathology examination revealed a benign neoplasm composed of a delicate fibrovascular core covered by normal-appearing urothelium. The patient underwent a successful proximal segment resection of the ureter by surgery.
Discussion:
Benign tumors of the ureter are much less frequent than malignant ones. Mostly, they involve the lower third of the ureter. Pain, hematuria, and hydronephrosis are the most clinical signs. The final diagnosis can be established with the histologic examination. The choice treatment in is segmental ureterectomy.
Conclusion:
Primary ureteral papilloma is extremely rare in the child. The histopathology study is essential for ruling out malignancy. The recurrence and progression of ureteral papilloma are controversial.
B-chronic lymphocytic leukemia showed triple transformation, to diffuse large B cell, CD20-negative, and T-cell neoplasm during ofatumumab treatment: a case report
Authors: Osamu Imataki, Makiko Uemura
Journal: BMC Clin Pathol (2018)
Keywords: chronic lymphocytic leukemia (cll), ofatumumab, richter’s syndrome, transformation
MeSH terms: Case Reports

Background:
Chronic lymphocytic leukemia (CLL) is a mature lymphoid neoplasm currently categorized as an indolent type of malignant lymphoma. CLL progresses slowly over years, but it eventually transforms to a more aggressive lymphoma such as the diffuse large B-cell (DLBCL) type, also known as Richter's syndrome.
Case presentation:
We treated a 69-year-old Japanese male who was histologically diagnosed with Richter's syndrome after 6 years of CLL. His lymphadenopathy had systemically progressed for years, with lymphocyte counts of less than 10,000 cells/μL and a disease status of Rai classification stage I and Binet classification B. He had high fever and hepatosplenomegaly upon Richter's transformation. The patient was treated with ofatumumab for refractory CLL, which relieved his febrile lymphadenopathy. He received a total of 11 ofatumumab courses and achieved partial remission. On the day of the 12th course of ofatumumab, his disease relapsed with febrile lymphadenopathy. Computed tomography revealed multiple liver masses and systemic lymphadenopathy, while a liver biopsy confirmed T-cell lymphoma. Concomitantly, CD20-lacking CLL cells were detected in his peripheral blood and bone marrow, and pathological examination of his left cervical lymph node biopsy showed CD20-positive DLBCL. The final diagnosis was three different types of lymphoma pathologies: (1) CD20-positive DLBCL of the lymph nodes, (2) CD20-lacking CLL of the peripheral blood and bone marrow, and (3) peripheral T-cell lymphoma (PTCL) of the liver. He received intravenous and oral dexamethasone therapy as palliative care. He died because of the rapid progression of abdominal masses 2 months after the diagnosis of triple transformation CLL. An autopsy revealed aggressive PTCL with aggressive systemic involvement of the liver, spleen, gall bladder, pericardium, bone marrow, and mediastinal-paraaortic-intraceliac lymph nodes. T-cell receptor study of an autopsy specimen supported the diagnosis of PTCL that spread to the intraceliac organs and lymph nodes. We concluded that his pathogenicity progressed to a mixture of triple lymphoma as a result of double malignant transformations, which included PTCL from CLL, CD20-negative CLL, and CD20-positive DLBCL by Richter's transformation.
Conclusions:
Our case provides information on the biology of CLL, to transform from a low-grade chemosensitive status to a malignant chemoresistant status.
Nasal paraganglioma: differential diagnosis from a radiologic and pathologic perspective
Authors: Christine J Tolman, Olga Cg Stam
Journal: BJR Case Rep (2016)
MeSH terms: Case Reports

A 33-year-old Asian male presented with spontaneous nosebleeds and olfactory sense problems for the past several years. CT scan and MRI demonstrated a large soft tissue mass in the nasal cavity and paranasal sinus with avid and homogeneous contrast enhancement, focal osseous destruction and a non-enhancing cyst at the intracranial tumour-brain margin. After complete endonasal resection, histopathological examination revealed a paraganglioma. This case highlights the non-specific imaging features of a rare paraganglioma of the anterior skull base and the differential diagnosis from both radiological and pathological perspective.
Renal Cell Carcinoma with Testicular Metastases: A Case Report and Review of the Literature
Authors: Sho Yoshitake, Brian M Shinder, Kevin Dazen, Colton Smith, Tina M Mayer, Evita Sadimin, Eric A Singer
Journal: J Kidney Cancer VHL (2022)
Keywords: clear cell, metastatic renal cell carcinoma, renal cell carcinoma, systemic therapy, testicular mass
MeSH terms: Case Reports

Renal cell carcinoma (RCC) metastases to the testicle are an extremely rare clinical entity. Here, we describe the case of a man with metastatic RCC who developed a new testicular mass. Pathologic analysis after surgical removal of this testicle confirmed the diagnosis of metastatic RCC. This report highlights the unique diagnostic and therapeutic challenges associated with such a disease process.
Eight-year Follow-up of Malignant Fibrous Histiocytoma (Undifferentiated High-grade Pleomorphic Sarcoma) of the Maxilla: Case Report and Review of the Literature
Authors: Hossein Shahoon, Mostafa Esmaeili, Mahsa Nematollahi
Journal: J Dent Res Dent Clin Dent Prospects (2009)
Keywords: oral cancer, malignant fibrous histiocytoma, maxilla, undifferentiated high grade pleomorphic sarcoma
MeSH terms: Case Reports

Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma of late adult life and may also arise as a primary tumor in bone. It is a rare condition that constitutes less than 1% of the malignant tumors of bone and commonly occurs in the mathaphysis of long bones of extremities such as the femur and tibia. The occurrence in the head and neck region is very rare. MFH of the jaws is a highly malignant tumor that recurs, metastasizes, and usually causes death despite aggressive surgical therapy. We present a case of MFH of maxilla with 8 years follow-up. The clinical, pathologic and radi-ographic features as well as the treatment of this case are discussed.
Severe spasm of the renal artery after blunt abdominal trauma simulating end-organ infarction
Authors: Adem Ucar, Aghakishi Yahyayev, Ayaz Agayev, Fatih Yanar, Selim Bakan, Mesut Bulakci, Tolga Akman, Ensar Yekeler
Journal: Case Rep Med (2010)
MeSH terms: Case Reports

Traumatic occlusion of the renal artery is a serious injury. Management differs according to the grade of injury. In most circumstances, emergency surgical revascularization or endovascular intervention is required. We describe the case of a child with multiorgan injuries and spasm of the main renal artery after blunt trauma simulating arterial occlusion or end-organ infarction.
Novel Role of Dehydrated Human Amnion/Chorion Membrane in Healing of Denuded Ureter in Robot-Assisted Excision of Endometriosis
Authors: Osamah Hasan, Grant S Johnson, James J Siegert, Francisco Garcini, Thai T Nguyen
Journal: Case Rep Obstet Gynecol (2019)
MeSH terms: Case Reports

Ureteral injury is an uncommon but potentially morbid complication following any open or endoscopic pelvic procedure. Gynecologic surgeries alone make up 50 percent of nonurologic ureteral injuries leading to prolonged hospital stays, secondary interventions, and potential loss of renal function. The use of AmnioFix ® a processed dehydrated, immunologically privileged cellular amniotic membrane allograft has been well established in urologic and gynecologic procedures. These allografts contain human extracellular matrix components, growth factors, and cytokines that mediate inflammation and facilitate would healing. We report the first application of AmnioFix on a denuded ureter during a case of robotic-assisted excision of endometriosis. We include a literature review and discussion on the management outcomes of iatrogenic injury to the ureters.
Improvement in Impaired Social Cognition but Not Seizures by Everolimus in a Child with Tuberous Sclerosis-Associated Autism through Increased Serum Antioxidant Proteins and Oxidant/Antioxidant Status
Authors: Kunio Yui, George Imataka, Hitomi Sasaki, Yohei Kawasaki, Tohru Okanshi, Ryoichi Shiroki, Shigemi Yoshihara
Journal: Case Rep Pediatr (2019)
MeSH terms: Case Reports

We investigated the effect of the mammalian target of rapamycin (mTOR) inhibitor everolimus on tuberous sclerosis complex- (TSC-) associated autistic symptoms and focal seizures with impaired awareness in a female child with TSC. We further evaluated the relationship between improved autistic symptoms and seizures and increased the serum levels of the antioxidant proteins, ceruloplasmin (Cp) and transferrin (Tf), and oxidant-antioxidant status indicated by the oxidant marker oxidized low-density lipoprotein (ox-LDL) and the antioxidant marker total antioxidant power (TAP). Everolimus treatment improved impaired social cognition and autistic behaviors; however, seizure and epileptic activity persisted. Serum Cp and Tf levels gradually increased in response to improved autistic symptoms. Serum TAP levels gradually decreased from baseline to the lowest value at 16 weeks and then increased at 24 weeks, showing a trend toward decreased total score of the Aberrant Behavior Checklist. This study revealed that everolimus treatment improved impaired social cognition with increased serum levels of the copper mediator (Cp) and iron mediator (Tf) via homeostatic control of mTOR activity accompanied by overlap of the oxidant-antioxidant system. Everolimus had no effect on TSC-related epileptiform discharges, and thus, the autistic symptoms and epileptic activity may be two independent end results of a common central nervous system disorder including mTOR hyperactivity. This trial is registered with JMAS-IIA00258.
Functional pancreatic neuroendocrine tumour causing Cushing's syndrome: the effect of chemotherapy on clinical symptoms
Authors: Paulo Henrique do Amor Divino, Katia Regina Marchetti, Madson Q Almeida, Rachel P Riechelmann
Journal: Ecancermedicalscience (2017)
Keywords: cushing syndrome, neuroendocrine tumours, pancreatic neoplasms
MeSH terms: Case Reports

Background:
Neuroendocrine tumours (NETs) are a heterogeneous group of diseases that can originate from any part of the gastrointestinal tract, bronchi, thyroid and pancreas. These tumours may be functioning or not depending on their ability to produce active substances, such as adrenocorticotrophic hormone (ACTH). ACTH-producing pancreatic neuroendocrine tumours are rare, with limited data about effective antitumor therapies.
Case report:
A 58-year-old man with a history of type-2 diabetes mellitus and arterial hypertension was diagnosed with Cushing's syndrome (CS) secondary to an ACTH ectopic production from a well-differentiated neuroendocrine tumour of the pancreas metastatic to the liver. The patient underwent initial body-caudal pancreatectomy, splenectomy and hepatic nodulectomy with subsequent recurrence. Hepatic embolisation and somatostatin analogues were used to control CS but without success. Bilateral adrenalectomy led to CS control, while capecitabine and oxaliplatin (CAPOX) was effective in controlling tumour growth and ACTH production.
Discussion:
ACTH-producing pancreatic neuroendocrine tumours are rare, aggressive and difficult to treat with available therapies. In settings of limited resources, such as in developing countries where targeted therapies are not available, cytotoxic chemotherapy with CAPOX represents a good and inexpensive option to control ACTH-producing pancreatic neuroendocrine tumours. Because of its complexity, the management of this tumour should be performed by multidisciplinary teams.
A Case of Esophago-Respiratory Fistula due to Inhalation Smoke Injury Diagnosed by Upper Endoscopy
Authors: Aida Nasirishargh, Bao Sean Huy Nguyen, Michael J Lawson, Eric J Mao
Journal: Case Rep Gastrointest Med (2023)
MeSH terms: Case Reports

Esophago-respiratory fistula (ERF) refers to the formation of a pathological connection between the esophagus and respiratory tract. Acquired ERF is a rare but life-threatening diagnosis in adults. We describe a 79-year-old male who was admitted with an inhalation smoke injury. He was diagnosed with ERF by endoscopic visualization and sampling of the hyaline cartilage within the wall of the esophagus. Percutaneous endoscopic gastrostomy placement and conservative measures were effective in the management of ERF.
Case report: A rare case of acute hemolysis in advanced rectal cancer after XELOX and nivolumab treatment: analysis of drug-dependent antibodies
Authors: Dengke Zhao, Qiao Song, Chunyan Wu, Shuye Wang
Journal: Front Med (Lausanne) (2023)
Keywords: colorectal cancer, drug-related hemolytic anemia, nivolumab, oxaliplatin, treatment
MeSH terms: Case Reports

Objective:
To investigate the mechanism, in vitro differential test and clinical significance of hemolytic anemia after receiving oxaliplatin and nivolumab treatment.
Methods:
We encountered a male patient with stage IV rectal cancer who experienced acute hemolysis during the ninth cycle of treatment with XELOX combined with nivolumab and cetuximab. The patient's blood samples were collected and tested for the presence of oxaliplatin or nivolumab antibodies on red blood cells.
Results:
Direct antiglobulin testing of red blood cells incubated with oxaliplatin was strongly positive, whereas cells incubated with nivolumab were negative, which suggested that oxaliplatin was responsible for the hemolysis. After short-term highdose glucocorticoid treatment, human normal immunoglobulin infusion, and other symptomatic treatments, the patient's condition rapidly improved, and he continued to receive nivolumab treatment without further hemolysis.
Conclusion:
Attention should be paid to the possibility of acute hemolysis when using oxaliplatin and nivolumab, and it is important to recognize and manage this adverse event early. We detected oxaliplatin-related antibodies on the surface of red blood cells in vitro, which provided evidence for the following treatments.
Myoma praevia and pregnancy
Authors: Yousra Krimou, Sanae Erraghay, Ahmed Guennoun, Nisrine Mamouni, Chahrazad Bouchikhi, Abdelaziz Banani
Journal: Pan Afr Med J (2019)
Keywords: myoma, dystocia, hemorrhage, miscarriage, praevia, pregnancy
MeSH terms: Leiomyoma / diagnostic imaging, Pregnancy Complications, Neoplastic / diagnostic imaging, Ultrasonography, Prenatal / methods, Uterine Neoplasms / diagnostic imaging, Case Reports, Adult, Cesarean Section, Female, Humans, Hysterectomy / methods, Leiomyoma / surgery, Pregnancy, Uterine Neoplasms / surgery

The association of myoma and pregnancy is becoming more frequent due to the increasing age of first pregnancy. It may affect the outcome of fertility, pregnancy, labor and peripartum course. A 37 years old patient was referred to our unit for discovering uterine leiomyoma at 37 weeks of pregnancy. Ultrasound screening showed a praevia isthmic leiomyoma measuring 16cm. A caesarean delivery was scheduled and a large interstitial isthmic uterine myoma measuring 25cm was found. Hysterectomy was corporeal. The post-operative and puerperium course was normal.
Multiple De Novo Cerebral Arteriovenous Malformations in a Patient with Alcoholic Liver Cirrhosis
Authors: Taehoon Do, Seung-Jae Lee, Jungbin Lee
Journal: J Belg Soc Radiol (2022)
Keywords: arteriovenous malformation, cerebral, hepatic failure, intracranial, liver cirrhosis, multiple
MeSH terms: Case Reports

Cerebral arteriovenous malformations (cAVMs) are traditionally considered congenital anomalies. The literature includes only two reported cases of de novo solitary cAVMs associated with liver cirrhosis (LC). Here, we report a unique case of multiple de novo cAVMs in a patient with alcoholic LC. Teaching point: In patients with potential risks for de novo cAVM, including liver cirrhosis, the possibility of multiple de novo cAVMs should be considered.
Non Typhoidal Salmonella Pyonephrosis in an Asymptomatic Immunocompetent Patient
Authors: Seif Mokadem, Mohamed Ali Nouioui, Salma Kalai, Tarek Taktak, Houssem Mediouni, Ramzi Khiari, Samir Ghozzi
Journal: Case Rep Urol (2019)
MeSH terms: Case Reports

A 50-year-old man with no past medical history presented with 5 months history of right flank discomfort. Physical examination was unremarkable. CT-scan showed a large right renal pelvic calculi and upper pole hydronephrosis. He underwent open surgical procedure and we peroperatively discovered upper pole pyonephrosis. Bacteriological samples of pus grew group D Salmonella. We prescribed third generation cephalosporin for 14 days. The patient made a steady recovery. Non typhoidal salmonella (NTS) urinary tract infection (UTI) is extremely rare and usually associated with immunosuppressive chronic disease or genito urinary tract abnormalities. Pyonephrosis due to NTS have been reported twice. We report the first case of asymptomatic NTS pyonephrosis.
Evidence of Asymptomatic Visual Losses after Surgical Repair of Cerebral Aneurysm
Authors: Albedy Moreira Bastos, Anderson Raiol Rodrigues, Maria Izabel Tentes Côrtes, Eliza Maria da Costa Brito Lacerda, Mônica Gomes Lima, Cláudio Eduardo Corrêa Teixeira, Luiz Carlos de Lima Silveira
Journal: Front Neurol (2017)
Keywords: aneurysm, clipping, contrast sensitivity function, visual acuity, visual field, visual losses
MeSH terms: Case Reports

Deficits in visual acuity, visual field, and oculomotor function are commonly detected after repair of cerebral aneurysms. However, when these deficits are absent, it does not mean that other potential visual deficits also are absent. Here, we report three cases that after complete recover from surgical repair of cerebral aneurysms presented minimal visual acuities of about 20/20 and no visual disturbances. While two of them (Cases 1 and 2) showed visual fields with no relevant central defects, two of them showed relevant impairments in spatial contrast sensitivity (Cases 2 and 3). This evidence supports that after complete recover from surgical repair of hemorrhagic cerebral aneurysms spatial contrast sensitivity can be asymptomatically impaired when visual acuity (Cases 2 and 3) and visual fields (Case 2) are not correlated with symptoms of visual disturbances. Hypothetical explanations and consequences of such evidence are discussed.