OpenMed/multicare-articles huggingface dataset:
Case report: Ovarian mucinous tumor with a mural nodule of liposarcoma: a rare case
Authors: Jiezhen Li, Haijian Huang, Qiang Zeng, Xin Chen, Lingfeng Chen
Journal: Front Oncol (2024)
Keywords: high-throughput sequencing, liposarcoma, mural nodule, ovarian mucinous tumor, pathological feature
MeSH terms: Case Reports

Background:
Ovarian mucinous tumor with a mural nodule is a rare and special type of ovarian surface epithelial-stromal tumor. Mural nodules are morphologically classified into three types: sarcoma-like, anaplastic carcinomatous, and true sarcomatous nodules. Ovarian mucinous tumors with true sarcomatous mural nodules are rare and challenging to diagnose, with only 10 cases reported worldwide. Currently, liposarcoma mural nodules remain unreported.
Case presentation:
A 91-year-old woman was hospitalized for postmenopausal vaginal bleeding for 3 weeks. Imaging revealed a large cystic mass (20.0 cm × 17.7 cm × 12.8 cm) on the right ovary. The mass was multilocular cystic, with a mural nodule (1.4 cm × 1.2 cm × 1.0 cm) in the focal cyst wall. Based on histological morphology, immunohistochemical staining, and MDM2/CDK4 fluorescence in situ hybridization testing, the diagnosis was ovarian mucinous cystadenoma with a mural nodule of well-differentiated liposarcoma. To the best of our knowledge, this has never been reported before. High-throughput sequencing identified KRAS mutations in the ovarian mucinous cystadenoma. However, the liposarcoma mural nodule did not exhibit KRAS mutations but displayed copy number amplifications of CDK4 and DDR2, as well as a frameshift mutation in exon 13 of ASXL1 (p. A627Gfs*8).
Conclusions:
This case broadens the morphological spectrum of mural nodules in ovarian mucinous tumors, deepening our knowledge of this rare morphology. Meanwhile, through high-throughput sequencing, we found no overlapping genetic evidence between the liposarcoma mural nodule and associated ovarian mucinous cystadenoma.
Thrombus entrapment with left atrial appendage closure to facilitate early cardioversion in tachycardiomyopathy: a case report
Authors: Jolie Bruno, Lorenz Räber, Bruno Schnegg, Livia Primiceri
Journal: Eur Heart J Case Rep (2023)
Keywords: atrial flutter, case report, left atrial appendage closure, tachycardiomyopathy, thrombus entrapment procedure
MeSH terms: Case Reports

Background:
The aetiological spectrum of heart failure with reduced ejection fraction is various. Tachycardiomyopathy is recognized as one of the cause, usually made retrospectively. In this clinical context, rhythm control with restoration of sinus rhythm is considered crucial to minimize ventricular function damage and allow contractility recovery. However, the presence of a thrombus in the left atrial appendage is a limiting factor, typically requiring anticoagulation until the thrombus resolves, at least 3 weeks, thus delaying the therapy.
Case summary:
We present a case of 65-year-old man with diagnosis of new-onset acute symptomatic heart failure with severe reduced ejection fraction (left ventricular ejection fraction 15%), in the context of a typical tachycardic atrial flutter and concomitant thrombus in the left atrial appendage confirmed by transoesophageal echocardiography. We successfully performed a thrombus entrapment procedure by means of percutaneous left atrial appendage closure, which allowed immediate restoration of sinus rhythm through cavotricuspid isthmus ablation. After the institution of the heart failure therapy, titrated up to the maximum tolerated dose, we observed a complete restoration of left ventricular function after 6 months.
Discussion:
Thrombus entrapment by means of left atrial appendage closure is a valid strategy that enables early cardioversion with arrhythmia ablation and rapid restoration of normal cardiac rhythm in severe heart failure with reduced ejection fraction, even in acute situations and typical atrial flutter.
Case report: Corpectomy and iliac crest bone autograft as treatment for a vertebral plasma cell tumor in a dachshund dog
Authors: Hannah R Yoder, Megan R MacRae, Olivia M Snead, Karl H Kraus
Journal: Front Vet Sci (2023)
Keywords: autograft, case report, corpectomy, ilium, multiple myeloma, plasma cell
MeSH terms: Case Reports

A 7-year-old, 7.5 kg, female spayed dachshund dog presented to a veterinary teaching hospital after being referred for lameness and the inability to urinate. The dog presented as weakly ambulatory paraparetic with intact pain perception. Computed tomographic (CT) imaging showed ventral bony lysis and periosteal proliferation of the L3 vertebra, consistent with a plasma cell tumor. A corpectomy of the L3 vertebra was performed and subsequently stabilized with autogenous cortico-cancellous iliac crest bone staves, autogenous cancellous bone, and bilaterally placed locking plates [String of Pearls (SOP®), Orthomed]. The dog recovered well, with no decrease in neurologic status overnight, and continued to improve until discharge. Upon a recheck exam at 4 weeks postoperatively, the dog appeared neurologically improved with only mild ambulatory proprioceptive ataxia of the hind limbs. This case demonstrates that the transposition of a non-vascularized iliac crest autogenous bone graft with stabilization via SOP® plates and screws can be used in the management of dogs with vertebral plasma cell tumors and should be considered as a surgical option in similarly affected cases.
Clear cell myomelanocytic tumor of ligamentum teres
Authors: Ariba Zaidi, Debajyoti Chatterjee, Venu Bhargav, Vikas Gupta, Ashim Das
Journal: Autops Case Rep (2024)
Keywords: immunohistochemistry, liver neoplasms, perivascular epithelioid cell neoplasms
MeSH terms: Case Reports

Clear cell myomelanocytic tumor (CCMMT) of the falciform ligament/ligamentum teres is a rare hepatic tumor, a variant of the perivascular epithelioid cell tumor (PEComa) family. CCMMT is the rarest variant of hepatic PEComas. Only a few cases of CCMMT have been reported in the English literature. Because of its rarity, less is known about its biological behavior. We present a case of a 31-year-old female who complained of abdominal pain, bilious vomiting, and abdominal fullness over two months. The radiological impression was of focal nodular hyperplasia. The histological examination of the resection specimen revealed a well-circumscribed tumor arranged in fascicles, sheets, and a whorling pattern. The tumor cells were spindle to epithelioid shaped with abundant clear to pale eosinophilic cytoplasm. The tumor cells expressed both myoid (smooth muscle actin) and melanocytic (MelanA and HMB45) markers, while they were negative for hepatocytic and vascular markers. Thus, based on histology and immunohistochemistry, a diagnosis of CCMMT was made. This case presents the diagnostic challenges of CCMMT and discusses the differential diagnosis with a literature review.
Novel Development of a Large Cerebral Cavernous Malformation in an Adolescent With a History of Familial Cerebral Cavernous Malformation Syndrome
Authors: Mary G McIntosh, Laura L Hayes
Journal: Cureus (2024)
Keywords: cerebral cavernous malformations, familial cerebral cavernous malformations, neuroradiology, pediatric neuroradiology, vascular anomaly
MeSH terms: Case Reports

Cerebral cavernous malformations (CCM) are capillary vascular malformations of the central nervous system (CNS). These lesions can be either familial or sporadic. We present a case of a 16-year-old girl with familial CCM syndrome who presented with a six-month history of chronic headaches. A magnetic resonance imaging (MRI) scan revealed a large cavernoma in the right frontal lobe that had not been present on a prior scan performed eight years earlier. This case presentation demonstrates the possibility of significant novel cavernoma development further into adolescence.
Rapid-onset diarrhoea in HIV patient: The importance of suspecting cholera in non-endemic areas
Authors: Meisie A Nkoane, Adegoke O Adefolalu
Journal: S Afr J Infect Dis (2024)
Keywords: hiv infection, vibrio cholerae, cholera, diarrhoea and vomiting, non-endemic area
MeSH terms: Case Reports

Cholera, a severe diarrhoeal disease caused by Vibrio cholerae is typically associated with inadequate potable water supply and poor sanitation. We report cholera disease presentation identified as a suspected case of acute diarrhoea (HIV/AIDS common condition) in a person living with HIV seen in a cholera non-endemic area.
Contribution:
We highlight the importance of recognizing cholera in cases of acute diarrhoea, especially among people with HIV, in resource-constraint areas that lack potable water supply.
Retreatment with a pipeline embolization device for recanalized aneurysms following stent-assisted coiling embolization
Authors: Yuhui Ling, Jie Liu, Liyun Zhou, Xiuzhi Xiang, Peiming Wang
Journal: Front Neurol (2023)
Keywords: antiplatelet therapy, intracranial aneurysm, pipeline embolization device, recanalization, stent-assisted coiling

Background and purpose:
Flow diverters have emerged as viable alternatives for the retreatment of recanalized aneurysms following stent-assisted coiling embolization. In this study, we aim to present our experience of retreatment for such aneurysms using the pipeline embolization device (PED).
Materials and methods:
This case series presents a retrospective single-center analysis of patients with recanalized aneurysms who underwent retreatment using the PED between July 2019 and April 2023, subsequent to stent-assisted coiling embolization.
Results:
The study includes five female patients, whose relevant clinical data were recorded. All patients had aneurysms located in the internal carotid artery, comprising two blood blister-like aneurysms and two giant aneurysms. Prior to the retreatment, two LVIS stents, two enterprise stents, and one solitaire stent were implanted. Among the five patients, one experienced a fatal post-operative subarachnoid hemorrhage, while two patients achieved complete embolization, and another patient achieved near-complete embolization during the last follow-up. Furthermore, one patient faced challenges during the placement of the PED and was unable to achieve successful deployment. We propose four overlapping relationships between a newly implanted PED and a previously deployed stent: (1) PED covering only the proximal end of the previous stent, (2) PED covering only the distal end of the previous stent, (3) PED covering both the proximal and distal ends of the previous stent, and (4) PED deployed within the previous stent. Antiplatelet therapy at our center involved daily dual therapy with aspirin (100 mg/day) and clopidogrel (75 mg/day) for at least 5 days before PED placement. Intra-arterial bolus administration of tirofiban (5 mcg/kg) was administered during or immediately after PED deployment, followed by a maintenance dose of 0.08 mcg/kg/min IV infusion for at least 24-48 h if necessary. Postprocedural dual antiplatelet therapy included clopidogrel (75 mg/day) for 6 months and aspirin (100 mg/day) for 12 months.
Conclusion:
The findings of this study support the efficacy of the PED for the retreatment of recanalized aneurysms following stent-assisted coiling embolization.
A Case Report of Recurrent Acute Laryngeal Dystonia With Different Novel Antipsychotics: Aripiprazole and Olanzapine
Authors: Anas Ibn Auf, Mohammed A Mohammed, Hasan Wahhas
Journal: Cureus (2024)
Keywords: antipsychotic, aripiprazole, laryngeal dystonia, mental health, olanzapine, side effects, stridor
MeSH terms: Case Reports

Acute laryngeal dystonia (ALD) is a rare side effect of antipsychotic medications, but it is a life-threatening condition. We are introducing the case of a 49-year-old Saudi single male, who has been known to have schizophrenia for the last 20 years. He developed three attacks of acute laryngeal dystonia owing to different antipsychotic medications. The first was because of haloperidol on a dose of 20 mg a day. After being treated for dystonia and stabilized physically, the patient received oral aripiprazole at a dose of 10 mg a day. Unfortunately, he developed acute laryngeal dystonia, and treatment had to be discontinued. The third attack of dystonia was two months later because of the use of olanzapine in a dose of only 5 mg/day. The patient was finally stabilized on quetiapine with no more side effects. This case highlights the importance of careful monitoring of patients who are receiving antipsychotic medications, even newer ones, to avoid, or treat, such a rare but serious side effect early.
Ventriculoperitoneal shunt for giant porencephaly: a case report and literature review
Authors: Dongsheng Lu, Jialiang Tan, Haitong Xu
Journal: Front Surg (2024)
Keywords: case report, cerebrospinal fluid (csf), epilepsy, magnetic resonance imaging, porencephaly (por), ventriculoperitoneal shunt
MeSH terms: Case Reports

Porencephaly (POR) is an exceedingly rare neurological disorder characterized by the presence of solitary or multiple regressive cerebrospinal fluid (CSF) cavities within the brain parenchyma. Currently, there is a limited understanding of the pathogenesis and treatment options for this condition, and clinical presentations can vary significantly. However, imaging plays a crucial role in diagnosis and determining the optimal treatment strategy, necessitating individualized comprehensive treatment upon detection. We reported a 25-year-old male case with persistent head pain that did not resolve with rest. Magnetic resonance imaging (MRI) confirmed the giant POR, and we finally performed a ventriculoperitoneal shunt, and the symptoms of intracranial hypertension were relieved after surgery.
Large cell neuroendocrine carcinoma of the cervix: a case report
Authors: Chunmei Li, Maoyuan Wu, Wenwen Zhang, Xiaoling Jiang, Lixia Zhang, Gangcheng Wang, Lianli He
Journal: Front Oncol (2024)
Keywords: advanced cervical cancer, case report, cervical cancer treatment, large cell, well-differentiated neuroendocrine carcinoma
MeSH terms: Case Reports

Large Cell Neuroendocrine Carcinoma (LCNEC) of the cervix is an extremely rare but highly aggressive type of cervical cancer and it requires multimodal therapy to improve their quality of life. At present, there are no established, standardized treatment protocols for managing large cell neuroendocrine carcinoma of the cervix. In this report, we present a case of a patient with cervical LCNEC, Who was a 39-year-old woman who presented with irregular vaginal bleeding accompanied by lower abdominal distension for over a month. Examination revealed a cauliflower-like cervical mass approximately 4cm in diameter, with the normal cervical architecture distorted and partially fused to the vaginal wall. Following further investigations, the stage assigned was IVB, and who was started on neoadjuvant chemotherapy with the TC (paclitaxel + carboplatin) regimen but during neoadjuvant chemotherapy, The patient developed a vaginal urinary leakage. Then, The patient underwent a comprehensive treatment regimen that included pelvic exenteration, urinary system reconstruction, pelvic floor reconstruction, and chemotherapy. Given the patient's positive immunohistochemistry for EGFR, the treatment was combined with the anti-angiogenic drug, bevacizumab. The patient achieved complete remission following the comprehensive treatment. Through this case to explore individualized treatment for cervical LCNEC.
Yokenella regensburgei urinary tract infection in an immunocompetent patient: a case report
Authors: Annie Sheeba V, Thangamani Suji, Selvin Theodore Jayanth, Rani Diana Sahni
Journal: Access Microbiol (2023)
Keywords: ampc, uti, yokenella
MeSH terms: Case Reports

Yokenella regensburgei , belonging to the order Enterobacterales , is a rare and emerging human pathogen reported to cause both superficial and invasive infections. The 13 case reports in the literature worldwide highlight blood, bone and wound infections. To our knowledge this is the first case description of Y. regensburgei causing a urinary tract infection in a 69-year-old immunocompetent patient which was isolated in two separate specimens and identified using matrix-assisted laser desorption ionization time-of-flight MS. It was found to be susceptible to most antimicrobials but resistant to penicillin, amoxicillin-clavulanate, cefoxitin and colistin. Inducible chromosomal ampC resistance was demonstrated on disc approximation testing, and blaYOC-1 class C beta-lactamase, beta lactamase superfamily and MBL fold metallo-hydrolase genes were found on whole genome sequencing.
Subsequent ovarian yolk sac tumor after operation of ovarian mature teratoma: a case report and review of the literature
Authors: Shuqing Li, Juan Peng, Yajun Zhang, Dongxia Liu, Lei Li, Manman Nai
Journal: Front Oncol (2024)
Keywords: case report, literature review, ovary, teratoma, yolk sac tumor
MeSH terms: Case Reports

Ovarian mature teratoma represents a benign ovarian tumor, while ovarian yolk sac tumor (YST, endodermal sinus tumor) is a rare malignant tumor predominantly affecting young women, often associated with a grim prognosis post-metastasis. Both ovarian mature teratoma and ovarian YST are germ cell tumors. There are few studies on the correlation between ovarian YST and mature teratoma. Recurrence or malignant transformation may occur following the surgical intervention for ovarian mature teratoma. However, the occurrence of YST subsequent to such procedures is notably rare. In this investigation, we reported a case involving a 24-year-old unmarried woman with both mature ovarian teratoma and YST within a brief 1-year interval. Regular reexamination protocols facilitated the early-stage detection of YST. The patient underwent surgical treatment, chemotherapy, and measures to preserve ovarian function, resulting in a favorable prognosis. Our primary purpose is to distill clinical insights from the diagnostic and therapeutic journey of this patient. Our purpose is to enhance medical professionals' awareness that YST may be secondary to mature teratoma. Additionally, we underscore the critical importance of routine postoperative surveillance for ovarian mature teratoma, emphasizing its pivotal role in early malignant tumor detection-a factor paramount to the prognosis of patients.
Autonomic Recalibration: A Promising Approach for Alleviating Myofascial Pain Explored in a Retrospective Case Series
Authors: Bob Seton, Rishika Pandey, Mary K Piscura, William G Pearson Jr
Journal: Cureus (2024)
Keywords: autonomic recalibration, dysfunctional pain, hypervigilance, manual therapy methods, musculoskeletal system, myofascial trigger point, neuroplastic adaptations, non-opiate pain control, pain neutralization technique, primal reflex release technique
MeSH terms: Case Reports

This retrospective case series introduces autonomic recalibration (AR) as a novel approach for alleviating chronic myofascial pain. The manuscript explores the rationale, theory, and practice of AR, which targets the autonomic nervous system (ANS) to restore homeostasis and reduce pain. The involvement of the ANS in pain modulation and the role of autonomic imbalance in chronic pain are discussed, emphasizing the potential benefits of addressing autonomic dysregulation through AR. The technique combines manual interventions and patient education, relying on neuroplastic adaptations. Three diverse case reports are presented to illustrate the effectiveness of AR in patients with different sources of pain. Each case presents a unique clinical scenario, including a nine-year-old male diagnosed with spondylolisthesis, a 68-year-old male with a history of abdominal surgeries, and a 56-year-old male with chronic low back pain following lumbar fusion surgery. In all cases, AR resulted in pain relief, improved sleep, and restoration of functional abilities. These findings support the potential of AR as an effective alternative approach for myofascial pain. Further research is warranted to validate these outcomes and investigate the underlying mechanisms of AR.
Multiple uremic tumoral calcinosis in periarticular soft tissues with chronic renal failure: a case report
Authors: Lijin He, Meifang Li, Chenlan Lin, Kunlong Yan, Chengmin Yang, Jing Tang
Journal: Front Endocrinol (Lausanne) (2023)
Keywords: hemodialysis, imaging features, recurrence, surgical excision, uremic tumoral calcinosis
MeSH terms: Case Reports

Uremic tumoral calcinosis (UTC) is an uncommon and severe complication of hemodialysis therapy. The most important pathogenic factor involved in UTC is an increase in calcium-phosphorus products. We report here a patient undergoing hemodialysis for renal failure caused by hypertensive nephropathy who presented multiple UTCs in the right shoulder, left elbow and wrist. After surgical excision, they all recurred, with a similar UTC in the left shoulder. By observing the imaging features of various imaging examinations during the whole period of this case, including X-ray, computed tomography (CT), magnetic resonance imaging (MRI), and single-photon emission computed tomography (SPECT), we highlight the importance of imaging for evaluating the state of UTC regarding treatment options, further deepening our understanding of the imaging manifestations for this disease and their clinical significance.
Extra-Ocular Sebaceous Carcinoma Unveiled: A Case Study of Dermal Challenges in an Elderly African American Patient
Authors: Kaitlyn Pearl, Patricia Zielinski, Bernard J Zaragoza
Journal: Cureus (2024)
Keywords: back mass, cutaneous oncology, derm path, dermatology, extraocular sebaceous carcinoma, malignancy surgery, sebaceous carcinoma
MeSH terms: Case Reports

Sebaceous carcinoma is a rare malignant tumor of the sebaceous glands that most commonly presents in the periocular area. Uncommon extraocular manifestations are occasionally observed, often limited to the head or neck but can occur wherever sebaceous glands are found. There are increasing cases of sebaceous carcinoma in the United States which continue to pose ongoing diagnostic challenges. We present a patient with a 5.5 x 4 x 2 cm gradually growing necrotic and fungating upper back mass, present for one year. This lesion was initially diagnosed as an excoriated sebaceous adenoma, microscopically showing well-formed organoid structures and no irregular infiltration into the dermis, but was later confirmed as sebaceous carcinoma, demonstrating prominent mitosis and infiltrative growth pattern, following wide surgical excision. Margins were clear following the surgery with no signs of recurrence but further treatment recommendations included follow-up with oncology due to the rarity and aggressive nature of this tumor. This case serves to present an atypical presentation of a rare malignancy that has an increased occurrence rate for unknown reasons.