OpenMed/multicare-articles huggingface dataset:
A case of completely isolated advanced enteric duplication cyst cancer performed partial pancreatectomy
Authors: Shinsuke Nakashima, Terumasa Yamada, Go Sato, Takaaki Sakai, Yoshinao Chinen, Hiroaki Itakura, Ryo Kato, Masami Ueda, Yujiro Tsuda, Katsuya Ohta, Jin Matsuyama, Masakazu Ikenaga
Journal: Int J Surg Case Rep (2019)
Keywords: duplication cyst cancer, enteric duplication cyst, pancreatic cyst

Introduction:
Enteric duplication cysts are rare and, in addition, isolated enteric duplication cysts are lower morbidity prevalence rate. These cysts lack a connection to the gastrointestinal tract or the adjacent mesenteric vasculature and have only been reported in 10 case reports. In these reports, only two reports were cases with malignant transformation. Our case was a report for the advanced cancer of the isolated enteric duplication cyst.
Case presentation:
The patient was a 43 year-old woman with slightly abdominal pain and mass formation. The abdominal contrast-enhanced computed tomography showed 130 × 100 × 90 mm huge cystic mass existed in right upper peritoneal cavity. The cystic mass had thickened wall and many enhanced nodules. As these imaging findings suggested a tumor originated from pancreas and the preoperative diagnose was suspect of mucinous cystic neoplasm. In operative findings, the tumor originated from pancreatic head and did not attach to gastrointestinal tract. Final pathology indicated the cyst was an isolated advanced enteric duplication cyst cancer and not originated from pancreas.
Conclusion:
We experienced an extremely rare case of completely isolated advanced enteric duplication cyst cancer. Unique to this case, the preoperative diagnosis was suspect of mucinous cystic neoplasm arising from pancreas head and partial pancreatectomy was performed. However, in the pathological findings, this cyst diagnosed advanced enteric duplication cyst cancer.
Emergence of Lassa Fever Disease in Northern Togo: Report of Two Cases in Oti District in 2016
Authors: Akouda Akessiwe Patassi, Dadja Essoya Landoh, Agballa Mebiny-Essoh Tchalla, Wemboo Afiwa Halatoko, Hamadi Assane, Bayaki Saka, Mouchedou Abdoukarim Naba, Issifou Yaya, Kossi Atsissinta Edou, Tsidi Agbeko Tamekloe, Abiba Kere Banla, Kokou Mawule Davi, Magloire Manga, Yao Kassankogno, Dominique Salmon-Ceron
Journal: Case Rep Infect Dis (2017)
MeSH terms: Case Reports

Background:
Lassa fever belongs to the group of potentially fatal hemorrhagic fevers, never reported in Togo. The aim of this paper is to report the first two cases of Lassa fever infection in Togo.
Case presentation:
The two first Lassa fever cases occurred in two expatriate's health professionals working in Togo for more than two years. The symptoms appeared among two health professionals of a clinic located in Oti district in the north of the country. The absence of clinical improvement after antimalarial treatment and the worsening of clinical symptoms led to the medical evacuation. The delayed diagnosis of the first case led to a fatal outcome. The second case recovered under ribavirin treatment.
Conclusion:
The emergence of this hemorrhagic fever confirms the existence of Lassa fever virus in Togo. After a period of intensive Ebola virus transmission from 2013 to 2015, this is an additional call for the establishment and enhancement of infection prevention and control measures in the health care setting in West Africa.
Case report: imaging and treatment of ophthalmic manifestations in oculodentodigital dysplasia
Authors: Sameh Mosaed, Bradley H Jacobsen, Ken Young Lin
Journal: BMC Ophthalmol (2016)
MeSH terms: Ciliary Body / diagnostic imaging, Craniofacial Abnormalities / diagnosis, Cysts / diagnostic imaging, Eye Abnormalities / diagnosis, Foot Deformities, Congenital / diagnosis, Glaucoma Drainage Implants, Glaucoma, Angle-Closure / diagnostic imaging, Microscopy, Acoustic, Syndactyly / diagnosis, Tooth Abnormalities / diagnosis, Uveal Diseases / diagnostic imaging, Case Reports, Research Support, Non-U.S. Gov't, Child, Chronic Disease, Cysts / surgery, Female, Glaucoma, Angle-Closure / surgery, Gonioscopy, Humans, Intraocular Pressure, Uveal Diseases / surgery, Oculodentodigital Dysplasia

Background:
Diagnostic and surgical management of severe chronic angle- closure glaucoma secondary to ciliary body cysts can be difficult to manage in a patient with oculodentodigital dysplasia.
Case presentation:
A 6-year old girl with oculodentodigital dysplasia, with progressive chronic angle- closure glaucoma secondary to ciliary body cysts presented to our clinic. The initial examination revealed counting fingers vision in the left eye. Intraocular pressure (IOP), as assessed by tonopen, was 31 mm Hg. Ultrasound biomicroscopy revealed ciliary body cysts in the left eye, and gonioscopy confirmed chronic angle closure. A tube shunt was placed to control the elevated IOP. A year after her tube shunt placement in the left eye, ultrasound biomiscropy was performed on her right eye and showed no ciliary body cysts. Gonioscopy in the right eye revealed an open angle to the ciliary body band. Subsequent serial gonioscopy every 3 months showed gradual narrowing of the right eye angle and finally three-and-a-half years after tube placement of the left eye, her right eye IOP became uncontrolled with medications alone and a tube shunt was similarly placed in the right eye. Intraoperative ultrasound biomicroscopy performed at the time of the right eye tube shunt revealed extensive ciliary body cysts in the right eye. Her IOP in both eyes have been well controlled since the placement of tube shunts.
Conclusions:
This is one of the first reported cases of severe chronic angle- closure glaucoma secondary to ciliary body cysts in a patient with oculodentodigital dysplasia. We believe that early screening for ciliary body cysts is important in patients with oculodentodigital dysplasia.
A novel compound heterozygous mutation in TTC8 identified in a Japanese patient
Authors: Shigeru Sato, Takeshi Morimoto, Kikuko Hotta, Takashi Fujikado, Kohji Nishida
Journal: Hum Genome Var (2019)
MeSH terms: Case Reports

Bardet-Biedl syndrome (BBS), characterized by rod-cone dystrophy, postaxial polydactyly, central obesity, hypogonadism, renal abnormalities, and mental retardation, is a rare autosomal recessive disorder. To date, 21 causative genes have been reported. Here we describe a Japanese BBS patient with a novel compound heterozygous mutation in TTC8. To the best of our knowledge, this is the first description of a BBS patient with a mutation in the TTC8 gene in Japan.
Shock in the Setting of Diamond-Blackfan Anemia Relapse
Authors: Metri Haddaden, Samir Husami, Modar Alom, Yifan Pang, Zaid Imam, Daniel Keena
Journal: Case Rep Cardiol (2021)
MeSH terms: Case Reports

Adult intensivists have increasing exposure to individuals with congenital diseases surviving into adulthood. Solid knowledge bases and early recognition of the possible sequelae of congenital disorders are crucial in caring for these patients. We present a challenging case of shock and relapse of Diamond-Blackfan anemia in a 42-year-old man lost to follow-up for 18 years and highlighted the importance of healthcare transitions into adulthood and the challenges faced by health care systems to develop new strategies successfully transitioning complex pediatric patients to adult care.
Missense mutation of SERPINC1 (p.Ser426Leu) in a young patient presenting as refractory and recurrent venous thromboembolism: A case report
Authors: Haixu Yu, Xiaoyan Gai, Jianli Wang, Jinman Zhuang, Wanwan Guo, Rui Qiao, Hong Zhu, Yongchang Sun
Journal: Front Cardiovasc Med (2022)
Keywords: serpinc1, antithrombin deficiency, case report, missense mutation, refractory and recurrent vte, venous thromboembolism
MeSH terms: Case Reports

Genetic and acquired risk factors are extremely important mechanisms in the development of venous thromboembolism (VTE). Inherited antithrombin (AT) deficiency due to mutations in the SERPINC1 gene is a well-known risk factor for genetic thrombophilia. In this case, we reported a 28-year young abroad student who presented with refractory and recurrent VTE in-hospital. This patient presented with a 2-month history of right lower limb pain and 1 week of fever. The ultrasound showed deep venous thrombosis in the right common and superficial femoral veins. The CTPA confirmed acute pulmonary embolism with multiple filling defects in both pulmonary arteries. He was diagnosed with "pulmonary embolism, pneumonia, lower extremity venous thrombosis". The level of serum antithrombin was normal, yet gene sequencing revealed a heterozygous missense mutation of SERPINC1, c.1277C>T (p.Ser426Leu). The patient underwent anticoagulant therapy of heparin and inferior vena cava filter implantation. The patient had undergone recurrent VTE despite adequate anticoagulation with heparin during the first 2 weeks. The swelling, pain, and thrombosis of lower extremity veins got resolved from warfarin and rivaroxaban. Inherited antithrombin deficiency due to mutations in the SERPINC1 gene is the genetic basis of this patient, and warfarin/rivaroxaban, other than heparin, is beneficial.
Detection of Echovirus-18 in Children Suspected With SARS-CoV-2 Infection With Multisystem Inflammatory Syndrome: A Case Report From India
Authors: Mallika Lavania, Rajlakshmi Viswanathan, Sumit Dutt Bhardwaj, Jitendra S Oswal, Nutan Chavan, Manohar Shinde, Savita Katendra
Journal: Front Public Health (2022)
Keywords: covid-19, echovirus-18, mis-c, sars-cov-2, pediatric patients
MeSH terms: COVID-19 / complications, Case Reports, Research Support, Non-U.S. Gov't, Adolescent, COVID-19 Testing, Child, Enterovirus B, Human, Humans, SARS-CoV-2, Systemic Inflammatory Response Syndrome, pediatric multisystem inflammatory disease, COVID-19 related

There have been several reports across the globe regarding the presentation of a severe multi-system hyperinflammatory syndrome, resembling Kawasaki disease (KD), in the pediatric population during the SARS-CoV-2 pandemic. The exact pathophysiology is still unclear; however, children typically demonstrate multi-organ dysfunction and less respiratory system involvement compared to adults. The limited literature is available at present for the identification and management of such patients. In this study, we investigated four cases in children ages 11-15 years that fulfilled the case definition for the pediatric multi-system inflammatory syndrome. All were found negative for SARS-CoV-2 from oropharyngeal swabs and stool. As they were having symptoms of diarrhea, tests for bacterial and enteric viral infections were performed after SARS-CoV-2 testing. Molecular analysis revealed that all the children were infected with enterovirus (Echovirus-18). Early and exact diagnosis is vital for timely, effective, and potentially life-saving management of such cases.
Space Maintenance with an Innovative "Tube and Loop" Space Maintainer (Nikhil Appliance)
Authors: Nikhil Srivastava, Jyotika Grover, Prerna Panthri
Journal: Int J Clin Pediatr Dent (2016)
Keywords: band and loop, premature loss, tube and loop
MeSH terms: Case Reports

Despite the best efforts in prevention, premature loss of primary teeth continues to be a common problem in pediatric dentistry, resulting in disruption of arch integrity and adversely affecting the proper alignment of permanent successors. Space maintainers (SMs) are special appliances used for maintaining space created due to premature loss of primary teeth. Band and loop SM is mostly indicated for the premature loss of single primary molar, but this appliance has a number of limitations both for operators and for patients. Presented in this article is an innovative "Tube and Loop" SM (Nikhil appliance) which offers several advantages over the conventional band and loop SM. It is not only easy and quick to fabricate but can also be completed in a single sitting and cumbersome steps like impression making and laboratory procedures namely soldering are eliminated. How to cite this article: Srivastava N, Grover J, Panthri P. Space Maintenance with an Innovative "Tube and Loop" Space Maintainer (Nikhil Appliance). Int J Clin Pediatr Dent 2016;9(1):86-89.
Diagnosis and management of a urethral prolapse in a 6-year-old girl: a case report
Authors: Armand Mayala Ma Mayala, Philippe Lukanu Ngwala, Jean-Pierre Fina Lubaki
Journal: Pan Afr Med J (2021)
Keywords: urethral prolapse, case report, prepubescent girl
MeSH terms: Hemorrhage / etiology, Pelvic Organ Prolapse / diagnosis, Urethral Diseases / diagnosis, Case Reports, Child, Female, Follow-Up Studies, Humans, Pelvic Organ Prolapse / therapy, Treatment Outcome, Urethral Diseases / therapy

Urethral prolapse is a very rare disease, which is most often found in prepubescent girls. It occurs in about one over 5000 girls in the context of a chronic cough or any situation that increases abdominal pressure. It is often associated with diagnostic confusion, which delays management. We report the case of a 6-year-old child brought in urgently by her parents for a minimal genital hemorrhage and presence of a mass protruding from the vulva. In the hypothesis of a urethral prolapse, a medical treatment (conservative) was prescribed. After two weeks, the mass decreased significantly in volume and disappeared completely after 2 months.
Advantage of laparoscopic peritoneal toileting in acute peritonitis with unclear etiology: A case report with inspiring outcome (with video)
Authors: Md Sumon Rahman, Hasan Ul Banna, Md Nazmul Hasan, Mohammad Jumman
Journal: Int J Surg Case Rep (2020)
Keywords: case report, laparoscopy, laparotomy, peritonitis
MeSH terms: Case Reports

Introduction:
Acute peritonitis is a surgical emergency and is conventionally managed with exploratory laparotomy in many centers, but laparoscopy is not contraindicated in such conditions. Operative management remains a cornerstone treatment in peritonitis irrespective of the primary pathology.
Presentation of case:
A 32-years-old man was admitted with acute diffuse peritonitis. As he was clinically stable, we proceeded with conservative treatment and diagnostic workup. He did not respond by 24 h and CT imaging showed ascites, but no definite diagnosis could be made. Diagnostic laparoscopy was performed, thorough peritoneal toileting was done but surprisingly the etiology was unclear. Following laparoscopy, he responded well with an uneventful recovery.
Discussion:
Timely proper evaluation and correct intervention are a paramount concern for the positive outcome. Regarding the most effective operative approach (laparotomy or laparoscopy) in acute peritonitis remains controversial in the literature and laparoscopy has been considered as a relative contraindication. However, the laparoscopy is gaining wider acceptance as the limitations of laparoscopy are declining rapidly. We experienced a case of extensive peritonitis with unclear etiology which we managed successfully by laparoscopy.
Conclusion:
Laparoscopic approach in peritonitis is effective and helpful for accurate diagnosis and to minimize the hazards of an unnecessary laparotomy. This case report might encourage many surgeons to consider laparoscopic approach in peritonitis with confidence and to perform further studies.
Successful osimertinib rechallenge following drug-induced pneumonitis after previous anti-PDL1 exposure
Authors: Guilherme Harada, Fernando Costa Santini, Felipe Sales Nogueira Amorim Canedo, Leandro Jonata de Carvalho Oliveira, Henrique Bortot Zuppani, Gilberto De Castro Jr
Journal: Ecancermedicalscience (2019)
Keywords: brain metastases, immunotherapy, lung cancer, osimertinib, pneumonitis, rechallenge
MeSH terms: Case Reports

Osimertinib is a first-line treatment option for patients with metastatic non-small cell lung cancer (NSCLC) harbouring EGFR mutations. Pneumonitis is a severe adverse event (AE) related to osimertinib treatment which appears to be more frequent when associated with concurrent or previous anti-PD(L)1 exposure. Data regarding the efficacy and safety of osimertinib rechallenge, especially in the setting of central nervous system (CNS) metastases, are scarce. We herein describe a case of a 53-year-old patient with metastatic EGFR-mutated NSCLC, who developed pneumonitis after osimertinib treatment and was successfully rechallenged with 40 mg daily osimertinib, with CNS response. This dose reduction strategy may be an option for selected patients with brain metastases after tyrosine kinase inhibitors-induced AEs.
Vaginal cuff dehiscence following controlled ovarian stimulation recognized during egg retrieval
Authors: Alexandra Peyser, Avner Hershlag, Antoinette Sakaris, Tomer Singer
Journal: Fertil Res Pract (2019)
Keywords: controlled ovarian stimulation, egg retrieval, vaginal cuff dehiscence
MeSH terms: Case Reports

Background:
Vaginal cuff dehiscence is a rare complication of hysterectomy. Those who choose to undergo controlled ovarian stimulation (COS) and oocyte cryopreservation following hysterectomy must be aware that elevated abdominal pressure from stimulation as well as transvaginal ultrasound use during monitoring may increase the risk of cuff dehiscence.
Case:
We present a case of a 25-year-old patient who had undergone a hysterectomy four months prior for endometrial cancer who was found to have vaginal cuff dehiscence which was recognized at the time of egg retrieval after COS. Prompt recognition and appropriate management led to successful treatment.
Conclusion:
Patients presenting for oocyte cryopreservation following hysterectomy are at risk for cuff dehiscence. Providers should allow ample time for proper cuff healing prior to COS and oocyte cryopreservation.
Implications and Considerations of Dental Materials in MRI: A Case Report and Literature Review
Authors: Brenton J Wilson, Phoebe E O'hare, John Zacariah
Journal: Case Rep Dent (2020)
MeSH terms: Case Reports

Magnetic resonance imaging (MRI) has an increasing role as a diagnostic imaging modality. Dental materials have important implications on the use of MRI as a diagnostic imaging modality. A case of a dislodged crown while in an MRI machine prompted a review of the literature for the implications and considerations of dental materials with magnetic resonance technology. An understanding of the basic physics involved in magnetic resonance is required to appreciate the relevance of dental materials in an MRI scanner. This case report supported by a literature review recommends assessing a patient's crown retention prior to and after MRI scanning.
Enterocutaneous Fistula Secondary to Stump Appendicitis
Authors: Nelson Agostinho, Harinder K Bains, Franko Sardelic
Journal: Case Rep Surg (2017)
MeSH terms: Case Reports

The management of appendicitis with appendicectomy is very common in surgical practice. A recognised complication of appendicitis and appendicectomy is the formation of an enterocutaneous fistula. We present the case of a seventy-five-year-old woman who presented with an appendicocutaneous fistula on the background of an open appendicectomy performed sixty years prior to presentation.
A case in which laparoscopic right salpingo-oophorectomy was performed in a patient with a lumboperitoneal shunt
Authors: Mio Nakagawa, Tomomi Egawa-Takata, Yuri Kamino, Ayuko Otoshi, Yayoi Fukuda, Yoshimi Tokugawa, Chikako Tsukahara, Takashi Miyatake, Yukihiro Nishio
Journal: Int J Surg Case Rep (2020)
Keywords: case report, laparoscopic surgery, lumboperitoneal shunt, ovarian cyst, salpingo-oophorectomy, ventriculoperitoneal shunt
MeSH terms: Case Reports

Introduction:
Ventriculoperitoneal (VP shunts) and lumboperitoneal shunts (LP shunts) are used to treat hydrocephalus. The effectiveness of LP shunts has recently been demonstrated. Due to population aging, the number of patients with LP shunts is expected to increase.
Presentation of case:
A 51-year-old female, in whom an LP shunt had been inserted to treat hydrocephalus after a subarachnoid hemorrhage, underwent laparoscopic right salpingo-oophorectomy for a right endometriotic cyst. We consulted a neurosurgeon and confirmed the route of the shunt. We started a normal laparoscopic procedure. The head of the shunt tube was located in Douglas' pouch and was an obstacle to the procedure. We moved the head of the shunt tube to the vesicouterine pouch and successfully conducted the standard operation. We report the case together with a literature review.
Discussion:
There have been several reports about gynecological laparoscopic surgery being performed in patients with VP shunts. On the other hand, we did not find any English literature about gynecological laparoscopic surgery being conducted in patients with LP shunts during a PubMed search.
Conclusion:
This is the first report about gynecological laparoscopic surgery being performed in a patient with an LP shunt.
Congenital simple hamartoma of retinal pigment epithelium: clinical and imaging findings
Authors: Mehmet Yasin Teke, Pinar Ç Ozdal, Figen Batioglu, Ufuk Elgin, Faruk Oztürk
Journal: Case Rep Ophthalmol Med (2012)
MeSH terms: Case Reports

Congenital simple hamartoma of retinal pigment epithelium (CSHRPE) is a rare, asymptomatic, and incidentally detected benign lesion. However, it is very important to do the differential diagnosis from other pigmented retinal lesions. Its clinical presentation and imaging findings are very helpful in doing this differentiation. This paper presents clinical and imaging findings of a 56-year-old woman with incidentally detected CSHRPE. The lesion was small, heavily pigmented, well circumscribed, and slightly elevated. Optical coherence tomography (OCT) scanning was diagnostic and showed an elevated retina at the site of the lesion, increased optical reflectivity on its inner surface, optical shadowing of deeper structures, and clearly cut tumor margins. Ocular ultrasonography, fluorescein angiography, and fundus autofluorescence imaging which is firstly described in this report did not show any characteristic finding.
Uterine leiomyosarcoma with central nervous system metastases
Authors: Carina Meira Abrahão, Fernando Cotait Maluf
Journal: Ecancermedicalscience (2015)
Keywords: central nervous system, leiomyosarcoma, metastasis
MeSH terms: Case Reports

Leiomyosarcoma (LMS) is a rare tumour and comprises 2-3% of all malignant uterus neoplasms [1]. Leiomyosarcoma is characterised by aggressive behaviour, high recurrence rates, and poor overall survival, despite multimodal treatment [3]. Surgery is the main treatment and consists of total abdominal hysterectomy. A randomised trial consisting of 224 patients diagnosed with uterine sarcomas stage I and II showed that adjuvant radiotherapy improves locoregional control. The role of adjuvant chemotherapy is still unclear [1]. Unfortunately, roughly 50% of patients with organ-confined disease will usually develop distant metastasis to lung, peritoneum, liver, pelvic, and para-aortic lymph nodes. Brain metastases are extremely rare [5].
A Novel Germline SDHA Gene Mutation and Co-Occurring Somatic KIT Activating Mutation in a Patient With Pediatric Central Nervous System Germ Cell Tumor: Case Report
Authors: Xizan Yue, Bo Liu, Tiantian Han, Ningning Luo, Guanghua Lu, Didi Guo, Fanfeng Bu, Guangyu Wang
Journal: Front Oncol (2022)
Keywords: kit gene, sdha gene, central nervous system germ cell tumors, germline, pediatric
MeSH terms: Case Reports

Central nervous system germ cell tumors (CNS GCTs) are a heterogeneous group of primary CNS tumors. GCTs are more common and mostly observed in pediatric and young adult patients. CNS GCTs are divided into germinomas and non-germinomatous germ cell tumors (NGGCTs), with different therapeutic strategies depending on diagnosis. Herein, we report a patient with pediatric central nervous system germinoma harboring a somatic KIT p.Y823D and a heterozygous germline SDHA p. T396Nfs*14 mutation detected by next generation sequencing. After surgery, the patient received chemotherapy (temozolomide + nedaplatin + etoposide). This is the first report of a Chinese pediatric patient with CNS GCT harboring concurrent germline SDHA and somatic KIT mutation, which enriches molecular profiles of CNS GCTs and provides more molecular evidence of clinical diagnosis and potential targeted therapy in CNS GCTs.