OpenMed/multicare-articles huggingface dataset:
Hypothermia with Extreme Bradycardia following Spinal Cord Infarction of Septic Origin
Authors: Philippe Hantson, Thierry Duprez
Journal: Case Rep Neurol Med (2017)
MeSH terms: Case Reports

Among other autonomic dysfunctions complicating acute spinal cord injury, deep hypothermia is rare but may induce serious cardiovascular complications. There are few pharmacological options to influence hypothermia. A 66-year-old woman was transferred to the intensive care unit (ICU) for serious cardiac arrhythmias (atrial fibrillation and asystole) in the context of a deep hypothermia (axillary temperature below 32°C). She had been admitted to the hospital two months before for an acute L4-L5 infectious spondylodiscitis without any initial neurological deficit. After surgery for epidural abscess drainage, she became paraplegic due to spinal cord infarction (from C7 to T6 levels) in the upper territory of the anterior spinal artery. In the ICU, the patient experienced several episodes of asystole and hypotension associated with a core body temperature below 35°C. Common causes of hypothermia (drugs, hypothyroidism, etc.) were excluded. A definitive pacemaker had to be inserted, but hypotension persisted. The prescription of oral progesterone (200 mg·d-1) helped to maintain a core temperature higher than 35°C, with a withdrawal of vasopressors. This case report illustrates that patients with incomplete spinal cord injury may present with delayed and deep hypothermia leading to serious cardiovascular complications. Progesterone could be able to influence positively central and peripheral thermal regulation.
Peripheral ossifying fibroma
Authors: Mahavir B Mishra, Kundendu Arya Bhishen, Shanu Mishra
Journal: J Oral Maxillofac Pathol (2011)
Keywords: fibroblast, osteoid tissue, peripheral cemento-ossifying fibroma, peripheral ossifying fibroma, pyogenic granuloma
MeSH terms: Case Reports

Here, we present a case report of peripheral ossifying fibroma (POF) in an adult lady in her fourth decade of life. This case report comprises the growth that occurred in the mandibular anterior region with displacement of anterior teeth, its satisfactory management and literature review. POF represents a reactive benign lesion of connective tissue and is not the soft tissue counterpart of ossifying fibroma and is also not related anyhow to peripheral odontogenic fibroma. POF in the age of 45 years, arising in the mandibular anterior region, is an occasional entity. Careful clinical examination and histopathology findings should be correlated to conclude the final diagnosis.
Survival of a newborn from a pregnant woman with rabies infection
Authors: Zhen-Yu Qu, Guo-Wei Li, Qiao-Ge Chen, Peng Jiang, Chang Liu, Alfred Lam
Journal: J Venom Anim Toxins Incl Trop Dis (2016)
Keywords: newborn baby, pregnant, rabies
MeSH terms: Case Reports

Background:
Rabies is very common in People's Republic of China. Each year thousands of people die because of this disease, but rabies diagnosed in pregnancy is very rare.
Case presentation:
In this study, we report the case of a pregnant woman who was infected with the rabies virus after a dog bite. The symptoms of rabies appeared in labor and she died after pregnancy. Her baby and husband did not develop the disease.
Conclusion:
The phenomenon that the newborn infant was healthy may be related to the protective role of placenta in resisting the invasion of the rabies virus or the absence of systemic viremia. The prompt administration of vaccines and anti-rabies immunoglobulin to the infant may have also contributed to his survival.
Spontaneous Recovery of Penetrating Cervical Spinal Cord Injury with Physiotherapeutic Treatment: Case Report and Review of the Literature
Authors: Yao Christian Hugues Dokponou, Mamoune El Mostarchid, Housni Abderrahmane, Niamien Patrice Koffi, Miloudi Gazzaz, Brahim El Mostarchid
Journal: Case Rep Neurol Med (2021)
MeSH terms: Case Reports

Stab wounds to the cervical spine are less common than injuries from road accidents, sports injuries, and falls. The presence of vital, vascular, neural, respiratory, and digestive structures in the neck region mean that this kind of spinal injury is generally critical, and its management is a challenge. We report a unique case of a previously healthy 17-year-old adolescent admitted for quadriplegia secondary to a stab wound to the cervical spine at the C4C5 level. There was no surgical indication. The patient underwent physiotherapy. He showed spontaneous neurological improvement two weeks later and was able to sit on his own and to walk about three months of physical rehabilitation.
Pericardial calcification: A case report of a three-dimensional disease
Authors: Raja Ohri, Kareem Salhiyyah, Stephen Harding, Sunil Ohri
Journal: Int J Surg Case Rep (2019)
Keywords: constrictive pericarditis, pericardial calcification, three-dimensional imaging

Introduction:
Constrictive pericarditis is an important cause of diastolic heart failure. The relationship between the presence and degree of pericardial calcification with constrictive pericarditis is variable, however this should be an early warning sign to initiate appropriate investigations.
Presentation of case:
A 64-year-old gentleman presented with dyspnoea and dizziness on exertion. Plain posterior-anterior chest X-ray showed mild to moderate pericardial calcification. He had an episode of atrial fibrillation which resolved spontaneously and thought to be the cause of his symptoms. Patient symptoms progressed. Further investigations including CT scan confirmed extensive constrictive pericarditis. He underwent a successful percardiectomy and full recovery.
Discussion:
Constrictive pericarditis can be the consequence of different conditions such as tuberculosis, radiation, idiopathic or many others. Pericardial calcification is present in less than 25% of all cases of constrictive pericarditis, and patient with it are prone to develop atrial fibrillation. The presence of pericardial calcification on plain chest radiograph is an important indicator for the possibility of pericardial dysfunction. Many cases of pericardial calcification are benign without any clinical significance; however three-dimensional imaging is required to determine the calcium load and aid in reaching appropriate diagnosis.
Conclusion:
Chest X-ray is valuable detector of pericardial calcification, a surrogate of pericardial constriction, but it is important to remember that pericardial calcification is a three-dimensional condition, and should be further investigated by lateral chest X-ray, CT scan and then appropriate functional imaging.
Couples Coping With the Serious Illness of One of the Partners
Authors: Hélène Riazuelo
Journal: Front Psychol (2021)
Keywords: chronicity, couple, filiation, partner, reworking of family relations, serious somatic disease, spouse, transmission

Chronic kidney failure is a serious somatic disease. Addressing the issue of living with a chronic disease means fully considering the patients' entourage, their families, and those close to them, especially their children and spouses. Objectives: The present paper focuses on the couple's psychological experience when one of them suffers from a chronic disease, in this instance kidney disease. In particular, how is the spouse affected by the treatment provided? The aim is not only to see how care for sick people can be improved, but also, more specifically, how relatives and especially partners can receive attention. Methodology: A qualitative approach is not only adopted, being based on the psychotherapeutic follow-up of the partners of patients with chronic kidney disease, but also of the patients themselves, addressing the matter of their life as a couple. Three couples were considered, and two case studies are presented here. The issues that cut across these different situations are examined. Results and Discussion: Some couples show considerable resourcefulness. However, over the years, that capacity for adaptation and inventiveness can also be interrupted by the periods of greater suffering and even despair, especially when the somatic pathology becomes chronic. Many spouses talk about how living with a sick partner weighs down on them, causing severe fatigue. Some aspects of the illness can also become traumatic. The disease regularly disrupts the daily life of the couple and the family. This leads to a reworking of family relations. Each couple has its own history with the condition. As it emerges, it can disrupt the bonds of filiation, especially when the illness is hereditary. Making psychological care more accessible to the partners involved constitutes a major challenge for our hospital care systems.
A homozygous mutation in the stem II domain of RNU4ATAC causes typical Roifman syndrome
Authors: Yael Dinur Schejter, Adi Ovadia, Roumiana Alexandrova, Bhooma Thiruvahindrapuram, Sergio L Pereira, David E Manson, Ajoy Vincent, Daniele Merico, Chaim M Roifman
Journal: NPJ Genom Med (2017)
MeSH terms: Case Reports

Roifman syndrome (OMIM# 616651) is a complex syndrome encompassing skeletal dysplasia, immunodeficiency, retinal dystrophy and developmental delay, and is caused by compound heterozygous mutations involving the Stem II region and one of the other domains of the RNU4ATAC gene. This small nuclear RNA gene is essential for minor intron splicing. The Canadian Centre for Primary Immunodeficiency Registry and Repository were used to derive patient information as well as tissues. Utilising RNA sequencing methodologies, we analysed samples from patients with Roifman syndrome and assessed intron retention. We demonstrate that a homozygous mutation in Stem II is sufficient to cause the full spectrum of features associated with typical Roifman syndrome. Further, we demonstrate the same pattern of aberration in minor intron retention as found in cases with compound heterozygous mutations.
Successful renal replacement therapy for a patient with severe hemophilia after surgical treatment of intracranial hemorrhage and hydrocephalus
Authors: Noriko Kato, Masami Chin-Kanasaki, Yuki Tanaka, Mako Yasuda, Yukiyo Yokomaku, Masayoshi Sakaguchi, Keiji Isshiki, Shin-Ichi Araki, Shigeru Ohta, Takashi Uzu
Journal: Case Rep Nephrol (2011)
MeSH terms: Case Reports

A 21-year-old Japanese male with severe hemophilia A was developed end-stage renal failure. He was placed on combination therapy with peritoneal dialysis (PD) and hemodialysis (HD). Eight months later, he developed a hypertensive cerebral hemorrhage. After emergency surgery, he was managed with PD without HD to avoid cerebral edema. One month later, his renal replacement therapy was switched to HD (three times a week) from PD, since a ventriculoperitoneal shunt catheter was placed to treat his hydrocephalus. HD could be performed safety without anticoagulant agents on condition that factor VIII is given after every HD.
Development of Sciatic Neuropraxia following Abdominal Surgery in 3 Giant Breed Dogs
Authors: Laura Marti, Julia P Sumner
Journal: Case Rep Vet Med (2021)
MeSH terms: Case Reports

This report describes the clinical course of three giant breed dogs (2 Great Danes and 1 Saint Bernard) that developed sciatic neuropraxia following successful surgical management of gastric dilatation and volvulus (GDV). All three patients received physical rehabilitation with varying degrees of success. Two patients died of unrelated causes within a year of their initial presentation. The third case recovered nerve function and is alive with minimal neurologic deficits at the time of publication. This paper is aimed at positing potential causes for this complication and highlighting the importance of proper management of giant-breed dogs during hospitalization. Special attention should be given in regards to intraoperative positioning and postoperative care including frequent walks or changes in positioning, deep kennel bedding, and physical therapy.
Preimplantation Genetic Testing of Multiple Endocrine Neoplasia Type 2A
Authors: Anders Würgler Hansen, Laura Kirstine Sønderberg Roos, Kristine Løssl, Christian Godballe, Jes Sloth Mathiesen
Journal: Front Endocrinol (Lausanne) (2020)
Keywords: pgt-m, assisted reproductive technology, medullary thyroid carcinoma, multiple endocrine neopasia type 2, rearranged during transfection (ret)
MeSH terms: Genetic Testing, Multiple Endocrine Neoplasia Type 2a / diagnosis, Preimplantation Diagnosis, Case Reports, Adult, Female, Humans, Male, Pregnancy

Background: When discussing matters of reproduction, the 2015 revised guidelines for the management of medullary thyroid carcinoma recommend that patients diagnosed with multiple endocrine neoplasia type 2A (MEN 2A) are informed about the option of Preimplantation Genetic Testing for Monogenic Disorders (PGT-M). In addition, patients seem to have a genuine interest in reproductive options. However, there are just two reports worldwide of this technology being used for patients with MEN 2A. We here present, in a Danish couple where the man has MEN 2A, the first European family with children born after PGT-M. Objective: To report the results of PGT-M in relation to multiple endocrine neoplasia type 2A with the aim to increase awareness among physicians treating this and other genetic disorders. Methods: A Danish couple was referred to the PGT Center at Copenhagen University Hospital Rigshospitalet and opted for PGT-M after counseling by a clinical geneticist and a fertility doctor. The embryos were diagnosed using microsatellite polymorphic marker close to RET. Results: The couple had two healthy children born in 2017 and 2019 as a result of a total of three ICSI treatments including controlled ovarian stimulation, oocyte retrieval and PGT-M, and a total of six blastocyst transfers. Conclusion: A session with a clinical geneticist covering all reproductive options for patients in early adult life is a relevant part of the clinical management of patients with MEN 2A, and other patients with hereditary cancer predisposition syndromes.
A Case of Pregnancy Complicated with Evans Syndrome with Sequential Development of Autoimmune Warm Antibody Hemolytic Anemia and Idiopathic Thrombocytopenic Purpura
Authors: Haruka Suzuki, Koji Yamanoi, Jumpei Ogura, Takahiro Hirayama, Koji Yasumoto, Shimpei Shitanaka, Yoshihide Inayama, Mie Sakai, Tsutomu Ohara, Koh Suginami
Journal: Case Rep Obstet Gynecol (2019)
MeSH terms: Case Reports

The simultaneous or sequential development of autoimmune hemolytic anemia (AIHA) and idiopathic thrombocytopenic purpura (ITP) is known as Evans syndrome. We experienced a case of Evans syndrome that developed AIHA during pregnancy and ITP long after delivery. The patient was a 35-year-old pregnant woman (gravida 2, para 1). A routine blood test at 28 weeks of gestation revealed moderate macrocytic anemia. Her haptoglobin level was markedly low, and a direct antiglobulin test (DAT) was positive. Based on these results, AIHA was considered. A healthy female newborn with bodyweight 3575 g was vaginally delivered uneventfully. After delivery, the DAT remained positive, but anemia did not develop. At 203 days after delivery, ITP was detected. Because AIHA and ITP developed sequentially, she was diagnosed with Evans syndrome. When AIHA occurs during pregnancy, long-term follow-up is needed because ITP can develop sequentially.
Cardiogenic Shock and Guillain-Barré Syndrome as the First Manifestations of Pheochromocytoma
Authors: Maryam Heidarpour, Nafiseh Sereshti, Davood Shafie, Bijan Iraj, Hassan Rezvanian
Journal: Case Rep Endocrinol (2021)
MeSH terms: Case Reports

Febrile congestive heart failure is a rare first manifestation of pheochromocytoma. Herein, the case of a 31-year-old female with febrile congestive heart failure and subsequent cardiogenic shock is presented. After intensive care unit (ICU) admission and further evaluating the right adrenal mass observed in abdominal ultrasonography, the diagnosis of pheochromocytoma was confirmed. Then, she was scheduled for the right adrenalectomy. Before surgery, she complained of acute-onset progressive muscle weakness in the lower limbs, followed by the upper limbs. After further investigation, she was diagnosed with Guillain-Barré syndrome and treated with intravenous immunoglobulin (IVIG). She recovered well after the right adrenalectomy, and during the subsequent 18 months, the follow-up did not reveal any complications, and left ventricular function recovered to normal.
Promising clinical outcome after body gamma knife radiotherapy for mediastinal follicular dendritic cell sarcoma with thoracic spine invasion and iliac metastasis: A case report and literature review
Authors: Annan Hu, Ting Chen, Jian Dong
Journal: Front Oncol (2022)
Keywords: body gamma knife, follicular dendritic cell sarcoma, pathological complete response, separation surgery, stereotactic body radiotherapy
MeSH terms: Case Reports

Background:
Follicular dendritic cell sarcoma (FDCS) is a rare type of intermediate grade tumor. Mediastinal FDCS with spinal invasion has not been well described. The treatment options include surgical resection and radiation therapy. The body gamma knife is a stereotactic body radiotherapy (SBRT) technology that is widely used in China. The pathological evaluation of a bone lesion after a body gamma knife procedure has not been reported. Here, we report a case of a patient with FDCS with thoracic spine invasion and iliac metastasis treated with surgery and body gamma knife.
Case summary:
A 36-year-old male patient was hospitalized at Zhongshan Hospital, Fudan University, due to a gradually aggravated pain on the lateral side of the left scapula for 6 months. Imaging examination showed neoplastic lesions on the left side of C7-T2 invading the vertebral body of T1, T2, and caput costae of the second rib and suspected metastasis in the left ilium. FDCS was diagnosed after performing a computed tomography (CT)-guided core needle biopsy, and the thoracic lesion was surgically resected. The body gamma knife was used as an adjuvant radiotherapy for the thoracic lesion and a primary therapy for the left ilium lesion. Iliac bone lesion resection was performed at Zhongshan Hospital, Fudan University, 10 weeks after RT. Compared with the biopsy report, the body gamma knife treatment resulted in a pathological complete response (PCR). The magnetic resonance imaging (MRI) examinations showed stable disease of the thoracic lesion after body gamma knife radiosurgery.
Conclusion:
This case report describes the treatment of mediastinal FDCS with thoracic spinal invasion and iliac metastasis. The promising outcome suggests that separation surgery is an effective treatment option for mediastinal FDCS with spinal column invasion. It also demonstrates the application prospects of the body gamma knife treatment in malignant lesions of the axial bones.
Orthodontic treatment in patient with idiopathic root resorption: a case report
Authors: Diego Rey, Rosana Martínez Smit, Liliana Gamboa
Journal: Dental Press J Orthod (2015)
MeSH terms: Malocclusion, Angle Class I / therapy, Patient Care Planning, Root Resorption / complications, Case Reports, Adolescent, Cephalometry / methods, Diastema / therapy, Female, Humans, Orthodontic Appliance Design, Orthodontic Space Closure / instrumentation, Overbite / therapy, Tongue Habits / therapy, Tooth Movement Techniques / instrumentation, Treatment Outcome

Multiple idiopathic external root resorption is a rare pathological condition usually detected as an incidental radiographic finding. External root resorption of permanent teeth is a multifactorial process related to several local and systemic factors. If an etiological factor cannot be identified for root resorption, the term "idiopathic" is applied. This report presents a case of multiple idiopathic apical root resorption. The condition was found in a young female patient seeking orthodontic treatment due to malocclusion. This kind of resorption starts apically and progresses coronally, causing a gradual shortening and rounding of the remaining root. Patients with this condition are not the ideal candidates for orthodontic treatment; however, the aim of this report is to describe an unusual case of idiopathic root resorption involving the entire dentition, and to present the orthodontic treatment of this patient. It describes the progress and completion of orthodontic therapy with satisfactory end results.
A case of Brugada Syndrome unmasked by a postoperative febrile state
Authors: Jharendra Rijal, Smith Giri, Sumesh Khanal, Khagendra Dahal
Journal: Caspian J Intern Med (2015)
Keywords: arrythmias, brugada syndrome, electrocardiogram, appendectomy, fever
MeSH terms: Case Reports

Background:
Brugada Syndrome (BS) is an inherited ion channelopathy characterized by an electrocardiographic (ECG) pattern of a coved type ST segment elevation in right precordial leads with or without right bundle branch block.
Case presentation:
A 23-year old male presented with right lower quadrant abdominal pain. Further evaluation revealed a diagnosis of acute appendicitis. The patient developed a febrile episode on second post-operative day of laparoscopic appendectomy. ECG revealed features consistent with BS. Prompt control of temperature in the patient resolved the ST-segment elevation and prevented potentially life-threatening arrhythmias.
Conclusion:
Febrile episodes in susceptible patients may unmask a concealed BS. Prompt control of temperature is advocated to reduce the risk of life-threatening arrythmias.
Treatment of Generalized Anxiety Disorder with Gabapentin
Authors: Matej Markota, Robert J Morgan
Journal: Case Rep Psychiatry (2017)
MeSH terms: Case Reports

Gabapentin is frequently used in the treatment of anxiety disorders. However, there are no randomized controlled trials on the effectiveness of this medication in generalized anxiety disorder (GAD), and there are only a few case reports. We present a case of a 59-year-old female with a psychiatric history of GAD. The patient discontinued benzodiazepines after more than 7 years of daily treatment which led to rebound anxiety, benzodiazepine withdrawal symptoms, and suicidal ideation. She was psychiatrically hospitalized and started on gabapentin. Over the next 10 months of outpatient follow-up, she attempted to taper off gabapentin due to personal preference to limit medications. During this time, we observed a clear dose-response pattern of gabapentin on GAD symptoms. In the absence of controlled studies, these findings may offer important information about the effectiveness of gabapentin in GAD.
Post-partum Coronavirus Disease 19 Like Pneumonia Before the COVID-19 Italian Pandemic Outbreak: A Case Report
Authors: Andrea Busnelli, Alessandro Bulfoni, Andrea Caprotti, Stefano Acerboni, Paolo Emanuele Levi-Setti
Journal: Front Med (Lausanne) (2021)
Keywords: covid-19, klebsiella pneumoniae, coronavirus, pneumonia, post-partum
MeSH terms: Case Reports

Here we present a case of severe post-partum pneumonia that we observed at the end of January 2020. Specimen of blood was cultured and revealed Klebsiella pneumoniae bacteremia. However, the course of infection was atypical and the recovery time particularly long. Subsequently emerged COVID-19 hallmarks suggested to re-evaluate the case. After a multidisciplinary consultation, we concluded that, considering the clinical and imaging characteristics, the most likely hypothesis was that the patient was affected by novel Coronavirus pneumonia. The present case supports the hypothesis that Coronavirus might have circulated in northern Italy for weeks before its official detection.