OpenMed/multicare-articles huggingface dataset:
Post-ivermectin encephalopathy in Senegal: a case report
Authors: Daniel Gams Massi, Mohamed Lelouma Mansare, Mariétou Traoré, Moustapha Ndiaye, Amadou Gallo Diop, Mouhamadou Mansour Ndiaye
Journal: Pan Afr Med J (2017)
Keywords: ivermectin, corticosteroids, encephalopathy
MeSH terms: Antiparasitic Agents / adverse effects, Brain Diseases / etiology, Ivermectin / adverse effects, Medication Errors, Case Reports, Adult, Antiparasitic Agents / administration & dosage, Brain Diseases / diagnosis, Humans, Ivermectin / administration & dosage, Loiasis / diagnosis, Male, Senegal, Antiparasitic Agents, Ivermectin

Ivermectin is an ant parasitic drug used for combating onchocerciasis and lymphatic filariasis. It works by inhibiting the function of neurons and muscles, thus causing paralysis of microfilariae. Side effects of this drug have been reported including post-ivermectin encephalopathy requiring emergency care in hospital. We report the case of a 35 years old patient living in rural areas of Senegal who presented two days after a mistake in administration of a second dose of ivermectin, headaches, altered consciousness and bilateral blindness. The workup revealed brain white matter lesions, abnormal liver function tests and biological inflammation without evidence of Loa loa microfilariae in blood and cerebrospinal fluid. Corticosteroid treatment was administered in emergency and patient recovered despite the persistence of bilateral blindness. Inflammatory process seems to have an important role in the pathophysiology of this encephalopathy. We should therefore carefully control the administration of this drugs.
The Role of Therapeutic Anticoagulation in COVID-19
Authors: Ruth McGovern, Patrick Conway, Isabell Pekrul, Omar Tujjar
Journal: Case Rep Crit Care (2020)
MeSH terms: Case Reports

Coagulopathy has proven to be a common complication of the novel coronavirus SARS-CoV-2, with evidence of elevated D-dimers and fibrin degradation products associated with an increased incidence of thromboembolism. Despite emerging evidence describing the coagulopathy and its clinical relevance in COVID-19, fewer studies have addressed the potential role of empiric therapeutic anticoagulation in this setting. We report the case of a patient admitted to our intensive care unit (ICU) with severe acute respiratory distress syndrome (ARDS) secondary to COVID-19 whose clinical trajectory improved dramatically after initiation of a therapeutic dose of LMWH. The patient showed progressive elevation of fibrinogen and D-dimers despite a prophylactic dose of LMWH during her ICU stay. This was met with a moderate increase of troponin T-hs, an escalating need for vasopressors, and a progressive decrease in her P/F ratio despite preserved lung static compliance. Her platelet count was normal and had an elevated fibrinogen during the first week of ICU stay. The ECG was normal, and a bedside transthoracic echocardiogram showed no evidence of pulmonary embolism and a preserved EF with no regional wall motion abnormalities (RMWA). The chest X-ray was not dissimilar to previous exams, and the ABG showed hypoxia with normal pCO2 values. The decision was made to commence empiric therapeutic enoxaparin. The patient did not experience bleeding complications, and her clinical trajectory appeared to change dramatically. She was successfully extubated three days later and proceeded to clinical recovery and eventual discharge from the ICU. The available evidence shows that there is undoubtedly coagulopathy associated with COVID-19 with various subsequent forms of clinical manifestation described in the literature. Evidence also shows the benefits of heparin as an anticoagulant. From the discussion of this case report, however, it can be concluded that despite the plausible theoretical rationale, studies pertaining to the role of empiric therapeutic anticoagulation in this setting fall short of providing compelling evidence. Subsequently the role of empiric therapeutic anticoagulation in COVID-19 remains unclear with a pressing call for further research.
A rare fatal case of adenovirus serotype 4 associated acute disseminated encephalomyelitis in an adult: A case report
Authors: Zahra Qamar, Catherine M Tucker, Lawrence C Kenyon, Tricia L Royer
Journal: IDCases (2021)
Keywords: adem, acute disseminated encephalomyelitis, adenovirus, adult
MeSH terms: Case Reports

Acute disseminated encephalomyelitis (ADEM) is an autoimmune demyelinating disease directed against the myelin sheath of the central nervous system that typically presents 1-4 weeks after an infection or vaccination, most commonly in children. We describe a case of a young female who presented with rapidly progressive mental deterioration and died secondary to ADEM following an adenovirus upper respiratory tract infection.
Septate Uterus in a Girl with Rubinstein-Taybi Syndrome
Authors: Filipa de Castro Coelho, Sara Câmara, Inês Alves, Kathleen Brazão
Journal: Case Rep Pediatr (2018)
MeSH terms: Case Reports

Rubinstein-Taybi syndrome is an extremely rare plurimalformative condition that can affect any organ. However, reports regarding gynecological problems are unusual. We report the first case of a septate uterus in an adolescent with this syndrome, in agreement with the American Society for Reproductive Medicine (ASRM) and the Congenital Uterine Malformations by Expert (CUME) criteria for uterine septum. Additional studies are required to determine whether there is an increased frequency of müllerian duct anomalies with the condition. Our report extends the data on the clinical phenotype associated with Rubinstein-Taybi syndrome.
Antegrade CT pyelography of right retrocaval ureter causing ureteral stenosis and ureterohydronephrosis in an exotic shorthair cat: A case report
Authors: Bowen Zhang, Mengzhu Fu, Di Zhang, Yipeng Jin, Gang Liu
Journal: Front Vet Sci (2023)
Keywords: antegrade pyelography, computed tomography, retrocaval ureter, ultrasonography, ureterohydronephrosis
MeSH terms: Case Reports

Retrocaval ureter is a rarely reported congenital malformation of the caudal vena cava in veterinary medicine. In this report, a 2-year-old exotic shorthair cat weighing 3.4 kg was presented for depression and loss of appetite. Laboratory findings was unremarkable. Abdominal radiography revealed right renomegaly, and ultrasonography suggested right ureterohydronephrosis. Right retrocaval ureter was recognized by computed tomography. An antegrade pyelography was performed to identify the localization of obstruction and whether obstruction was complete or partial. Complete right ureteral stenosis was confirmed through right antegrade pyelography on computed tomography. The cat underwent right nephroureteroectomy and recovered well after surgery. This is the first report of successful diagnosis and treatment of retrocaval ureter in a cat with significant clinical and imaging signs, using ultrasonographically guided percutaneous antegrade pyelography and multimodal imaging such as radiography, ultrasonography, and computed tomography.
A Case of Adult Pancreatoblastoma With Novel APC Mutation and Genetic Heterogeneity
Authors: Yamato Suemitsu, Yusuke Ono, Yusuke Mizukami, Juanjuan Ye, Keiko Yamakawa, Takeshi Takamoto, Yuko Nakano-Narusawa, Yuri Mukai, Manabu Takamatsu, Atsuko Nakazawa, Mari Mino-Kenudson, Toshio Kumasaka, Yoko Matsuda
Journal: Front Oncol (2021)
Keywords: apc, basophilic cells, cartilaginous differentiation, clear cells, pancraetoblastoma, pancreatic neuroendocrine tumor (pannet), solid pseudopaillary neoplasm of the pancreas

Background:
Pancreatoblastoma is a rare malignant epithelial neoplasm of the pancreas that mainly occurs in children and involves abnormalities in the WNT/β-catenin pathway, such as CTNNB1 mutation. However, the molecular abnormalities in adult pancreatoblastoma are not well known.
Case presentation:
An elderly man, who underwent elective distal pancreatectomy and splenectomy, was referred to our hospital with a mass in the tail of the pancreas. Histologically, the lesion revealed proliferation of clear, basophilic, and cartilaginous tumor cells with lymphatic metastasis. Each of the morphologically distinct tumor components showed different immunohistochemical patterns, indicating heterogeneous differentiation, including epithelial (both acinar and ductal), mesenchymal, and neuroendocrine differentiation. All tumor components showed nuclear expression of β-catenin and cyclin D1. Per next-generation sequencing (NGS), the clear and basophilic tumor cells shared mutations in APC, GRM8, LAMP1, and AKA9. Among the mutations, APC, c.1816_1817insA showed the highest frequency in both cell types, indicating that APC mutation was a driver mutation of the tumor. A diagnosis of PB was rendered.
Summary:
In conclusion, the clear and basophilic cells of the tumor were supposedly derived from the same clone and subsequently acquired additional mutations. This is the first report of clonal evolution in pancreatoblastoma.
An Overlapping Case of IgG4-Related Disease and Systemic Lupus Erythematosus
Authors: Srikanth Naramala, Sharmi Biswas, Sreedhar Adapa, Vijay Gayam, Venu Madhav Konala, Subhasish Bose
Journal: J Investig Med High Impact Case Rep (2019)
Keywords: igg4-related disease, sle, lupus, systemic lupus erythematosus
MeSH terms: Immunoglobulin G4-Related Disease / complications, Lupus Erythematosus, Systemic / complications, Case Reports, Autoantibodies / immunology, Biopsy, Female, Humans, Immunoglobulin G4-Related Disease / diagnosis, Immunoglobulin G4-Related Disease / pathology, Lupus Erythematosus, Systemic / diagnosis, Lupus Erythematosus, Systemic / pathology, Lymph Nodes / pathology, Middle Aged, Autoantibodies

We are reporting a case of a 63-year-old Chinese female who presented to the rheumatology clinic with positive antinuclear antibody and unintentional weight loss along with lymphadenopathy. Further workup revealed eosinophilia, elevated anti-double stranded DNA, serum protein, and serum IgG4 (immunoglobulin G4). The patient was diagnosed with systemic lupus erythematosus. Due to the raised IgG4 level along with eosinophilia and diffuse lymphadenopathy, IgG4-related systemic disease was suspected. It was confirmed with IgG4 staining on lymph node biopsy. Our case is presenting the fact that systemic lupus erythematosus and IgG4-related disease can be present in the same patient with multiple overlapping features making accurate diagnosis challenging.
Bakody's Test Positive Thoracic Outlet Syndrome Caused by Anomalous Muscle: A Case Report
Authors: Ryota Kimura, Takashi Kobayashi, Naohisa Miyakoshi
Journal: Cureus (2023)
Keywords: anomalous muscle, bakody’s test, cervical spine anomalies, supraclavicular brachial plexus block, thoracic outlet syndrome
MeSH terms: Case Reports

Anomalous muscle causes thoracic outlet syndrome (TOS). A 40-year-old man presented with numbness of the left upper extremity, similar to cervical spondylotic radiculopathy. He presented with a positive Bakody's test. However, magnetic resonance imaging showed no significant changes in the cervical spine and revealed an anomalous muscle adjacent to the left brachial plexus. We diagnosed the muscle as the cause of TOS and performed a resection, which resulted in symptomatic improvement.
A Case of Long-Term Survival after Checkpoint Inhibitor Pneumonitis in a Patient with Squamous Cell Lung Cancer
Authors: Hironori Ashinuma, Satoko Mizuno, Yasushi Yoshida, Masato Shingyoji
Journal: Case Rep Oncol Med (2019)
MeSH terms: Case Reports

The management of grade 1 checkpoint inhibitor pneumonitis (CIP) is to withhold immune checkpoint inhibitors; however, the natural history of this condition is unknown. We herein report the case of a woman with squamous cell lung cancer who was a long-term survivor after CIP. After 4 rounds of treatment with nivolumab, a chest CT revealed a reticular pattern and ground-glass attenuation with shrinkage of the primary nodule. Nivolumab treatment was withheld without the administration of steroids. Although she remained asymptomatic, subsequent images revealed an increasing interstitial shadow until 2 months after the stop of nivolumab treatment. Thereafter, the interstitial shadow began to improve spontaneously without steroid treatment. Moreover, although the patient has not received additional therapy, disease control of lung cancer has been obtained within a follow-up period of more than 3 years. Although the exacerbation of CIP may appear on images for several months, asymptomatic cases can be followed without the administration of steroids. If the tumor had already responded prior to the onset of CIP, a favorable long-term prognosis can be expected.
An Unusual Case of Anti-GBM Antibody Elevation in HIV-Associated Nephropathy
Authors: Vinay Minocha, Raafat Makary, Andreea Poenariu
Journal: Case Rep Nephrol (2014)

Introduction. The most commonly seen glomerular disease in HIV infected patients is HIV-associated nephropathy (HIVAN); however, a multitude of other nephropathies can occur in HIV infection with an almost equal cumulative frequency. We report an unusual case of a patient with clinical and histological evidence of HIVAN in which the diagnosis was initially confounded by the finding of an elevated serum anti-glomerular basement membrane (anti-GBM) antibody. Case Presentation. We present a case of a 27-year-old African American female with a history of schizophrenia, cocaine abuse, and HIV infection who upon admission to our hospital was found to have severe acute kidney injury requiring hemodialysis. Urine studies revealed nephrotic range proteinuria and a serological workup was positive for anti-GBM antibody elevation with a value of 91 units (normal: 0-20 units). A renal biopsy revealed HIVAN with no evidence of crescentic glomerulonephritis or anti-GBM disease. Conclusion. This case highlights the need for careful interpretation of anti-GBM antibody tests in HIV infected patients with kidney disease and, in particular, the need for biopsy confirmation of the diagnosis prior to starting therapy. More research is needed to study the prognostic correlation between the degree of anti-GBM antibody elevation in HIVAN and disease severity.
Cervical canal stenosis due to cervical spondylotic myelopathy C4-C5: A case report
Authors: Ahmad Jabir Rahyussalim, Ifran Saleh, Muhammad Triadi Wijaya, Tri Kurniawati
Journal: Int J Surg Case Rep (2019)
Keywords: cervical spondylotic myelopathy, decompression, joa, neck pain, open-door laminoplasty, spine

Introduction:
Cervical spondylotic myelopathy (CSM) is a complex disease that presents with various signs and symptoms of cervical spinal cord impairment that may lead to significant clinical morbidity.
Presentation of case:
We present the case of a 50-year old man who was diagnosed with CSM. The patient underwent decompression and posterior stabilisation with open-door laminoplasty. At the 2-month follow-up, the pain subsided, function improved significantly, and weakness disappeared. The patient was also able to defecate and urinate normally.
Discussion:
Cervical spondylotic myelopathy is a complex disease that may lead to significant clinical morbidity. The management requires an extensive knowledge of the anatomy, biomechanics, and surgical options. The variable clinical findings, radiological evidence and scoring system, such as JOA, are important for preoperative evaluation and individualising surgical planning. The choice of the most appropriate technique is affected by patient's clinical condition and radiologic findings as well as surgeon's experience. It is demonstrated that the Kurokawa-type laminoplasty that involves splitting the spinous processes in the midline offers the advantage of reduced bleeding as the lateral epidural venous plexus is not disturbed in comparison to that with the former Hirabayashi's expansive open-door laminoplasty. Moreover, the body symmetry is preserved; therefore, this procedure may be considered more anatomical and physiological. However, differences in the outcomes between the two approaches remain unknown.
Conclusions:
These findings suggest that the decompression and posterior stabilisation method may help achieve good patient outcomes.
Case Report: A case report highlighting bilateral EDB wasting as a clinical marker for lumbar canal stenosis
Authors: Bijoy Mohan Kumar, Sunil Munakomi
Journal: F1000Res (2015)
Keywords: dural wasting, extensor digitorum brevis, lumbar canal stenosis

Herein we discuss a case of a 55 year old male presenting with history suggestive of sciatica on the left leg. Straight leg raising (SLR) test was positive at 45 degrees on the left side. His ankle reflex was absent and the power of extensor hallusus longus (EHL) was 4/5 on the same side. MRI lumbosacral spine revealed left paramedian disc prolapsed on L4/L5 level with spinal canal diameter of 9mm.However since his bilateral extensor digitorm brevis (EDB) were wasted, we suspected associated lumbar canal stenosis and thereby opted for laminectomy and discectomy in this case. Intraoperatively dural wasting, hypertrophied facets and narrow canal were confirmed. Laminectomy, medial facectectomy and discectomy were carried out. The patient recovered uneventfully with resolution of his sciatica-like pain. Bilateral EDB wasting thereby provides a clinical clue to the underlying lumbar canal stenosis and can help in making correct therapeutic decisions.
Monosomy 21 seen in live born is unlikely to represent true monosomy 21: a case report and review of the literature
Authors: Trent Burgess, Lilian Downie, Mark D Pertile, David Francis, Melissa Glass, Sara Nouri, Rosalynn Pszczola
Journal: Case Rep Genet (2014)

We report a case of a neonate who was shown with routine chromosome analysis on peripheral blood lymphocytes to have full monosomy 21. Further investigation on fibroblast cells using conventional chromosome and FISH analysis revealed two additional mosaic cell lines; one is containing a ring chromosome 21 and the other a double ring chromosome 21. In addition, chromosome microarray analysis (CMA) on fibroblasts showed a mosaic duplication of chromosome region 21q11.2q22.13 with approximately 45% of cells showing three copies of the proximal long arm segment, consistent with the presence of a mosaic ring chromosome 21 with ring instability. The CMA also showed complete monosomy for an 8.8 Mb terminal segment (21q22.13q22.3). Whilst this patient had a provisional clinical diagnosis of trisomy 21, the patient also had phenotypic features consistent with monosomy 21, such as prominent epicanthic folds, broad nasal bridge, anteverted nares, simple ears, and bilateral overlapping fifth fingers, features which can also be present in individuals with Down syndrome. The patient died at 4.5 months of age. This case highlights the need for additional studies using multiple tissue types and molecular testing methodologies in patients provisionally diagnosed with monosomy 21, in particular if detected in the neonatal period.
High-quality draft genome sequence and description of Haemophilus massiliensis sp. nov
Authors: Cheikh Ibrahima Lo, Senthil Alias Sankar, Bécaye Fall, Bissoume Sambe-Ba, Silman Diawara, Mamadou Wague Gueye, Oleg Mediannikov, Caroline Blanc-Tailleur, Boubacar Wade, Didier Raoult, Pierre-Edouard Fournier, Florence Fenollar
Journal: Stand Genomic Sci (2016)
Keywords: culturomics, genome, haemophilus massiliensis, taxono-genomics
MeSH terms: Case Reports

Strain FF7(T) was isolated from the peritoneal fluid of a 44-year-old woman who suffered from pelvic peritonitis. This strain exhibited a 16S rRNA sequence similarity of 94.8 % 16S rRNA sequence identity with Haemophilus parasuis, the phylogenetically closest species with a name with standing in nomenclature and a poor MALDI-TOF MS score (1.32 to 1.56) that does not allow any reliable identification. Using a polyphasic study made of phenotypic and genomic analyses, strain FF7(T) was a Gram-negative, facultatively anaerobic rod and member of the family Pasteurellaceae. It exhibited a genome of 2,442,548 bp long genome (one chromosome but no plasmid) contains 2,319 protein-coding and 67 RNA genes, including 6 rRNA operons. On the basis of these data, we propose the creation of Haemophilus massiliensis sp. nov. with strain FF7(T) (= CSUR P859 = DSM 28247) as the type strain.
Angiomatous Meningioma in the Craniocervical Junction
Authors: Shunsuke Ito, Yoichi Iizuka, Masanori Aihara, Hiromi Koshi, Tokue Mieda, Eiji Takasawa, Sho Ishiwata, Yusuke Tomomatsu, Akira Honda, Kazuhiro Inomata, Hirotaka Chikuda
Journal: Case Rep Orthop (2021)
MeSH terms: Case Reports

Introduction:
Spinal angiomatous meningioma arising in the craniocervical junction has not been reported. Case Presentation. A 68-year-old man presented to our hospital with pain in the back and left leg. He showed slight motor weakness in his upper extremities. Magnetic resonance imaging revealed a mass with marked enhancement in the craniocervical junction. Computed tomography angiography showed feeding vessels arising from the right vertebral artery. Preoperative embolization of the feeding vessels was performed to reduce intraoperative bleeding. Gross total resection of the tumor was achieved by debulking and piecemeal resection. The tumor attachment to the dura mater was also resected (Simpson grade 1 resection). A histopathological examination confirmed the diagnosis of an angiomatous meningioma. The patient's symptoms improved shortly after surgery.
Conclusions:
We achieved gross total resection of spinal angiomatous meningioma arising in the craniocervical junction. A preoperative evaluation and embolization of the feeding arteries may help prevent massive intraoperative bleeding.
Transoral Laser-Assisted Total Laryngectomy: Expanding the TLM's World
Authors: Aslan Ahmadi, Saleh Mohebbi, Masoud Kazemi, Ayda Sanaei
Journal: Case Rep Otolaryngol (2020)
MeSH terms: Case Reports

Introduction:
The introduction of laryngeal transoral procedures has created a shift in the treatment of laryngeal cancers towards the primary surgical management of patients. In this study, we aimed to evaluate the safety, efficacy, and feasibility of the transoral laser-assisted total laryngectomy (TLM-TL) in advanced laryngeal cancer. Case presentation. In this case report, we describe a case of a 50-year-old male patient presented to the otorhinolaryngology clinic with a history of hoarseness and odynophagia since 6 months. Based on the pathological and imaging findings, the diagnosis of stage IVa laryngeal squamous cell carcinoma with the involvement of the base, tongue, and left palatine tonsil was made for the patient, and transoral total laryngectomy with partial glossectomy via the TLM technique was planned.
Result:
The tumor was successfully resected by TLM-TL with clear surgical margins. No complication was observed after the surgery. Good functional recovery was obtained regarding swallowing and speech. The patient's oncologic and functional outcomes were evaluated for 2 years. Everything was satisfactory with good long-term cosmetic and laryngopharyngeal functional outcome and no sign of tumor recurrence.
Conclusions:
TLM-TL is a minimally invasive and cost-benefit endoscopic surgical procedure feasible in advanced laryngeal cancer with good long-term oncological and functional outcome. It could limit postoperative complications, mainly the incidence of pharyngocutaneous fistulae. It is also associated with better satisfaction after TL due to cosmetic benefits.