OpenMed/multicare-articles huggingface dataset:
A comprehensive approach in high-grade glioma management: position statement from the Neuro-Oncology Scientific Club (NOSC), Shiraz, Iran
Authors: Mansour Ansari, Ahmad Mosalaei, Niloufar Ahmadloo, Alireza Rasekhi, Bita Geramizadeh, Ali Razmkon, Kazem Anvari, Mohammad Afarid, Ali Dadras, Leila Nafarieh, Mohammad Mohammadianpanah, Hamid Nasrolahi, Seyed Hasan Hamedi, Shapour Omidvari, Mohammad Nami
Journal: Ger Med Sci (2017)
Keywords: shiraz, high-grade glioma, interdisciplinary, neuro-oncology, position statement
MeSH terms: Brain Neoplasms / therapy, Glioma / therapy, Patient Care Team / organization & administration, Review, Adult, Brain Neoplasms / diagnosis, Brain Neoplasms / diagnostic imaging, Combined Modality Therapy, Critical Pathways, Glioma / diagnosis, Glioma / diagnostic imaging, Humans, Iran, Magnetic Resonance Imaging, Medical Oncology / methods, Medical Oncology / organization & administration, Neuroimaging

Establishing a robust teamwork model in the practice of neuro-oncology requires continued interdisciplinary efforts. The Neuro-Oncology Scientific Club (NOSC) initiative is an interdisciplinary clinical forum promoting the comprehensive approach across involved disciplines in the management of central nervous system (CNS) malignancies. With its provincial founding panels and national steering board, NOSC has been operational in Iran since 2011. This initiative has pursued its mission through interval strategic meetings, tumor boards, case discussions as well as publishing neuro-oncology updates, case study periodicals, and newsletters. A provincial meeting of NOSC in Shiraz put together insights from international practice guidelines, emerging evidence, and expert opinions to draw a position statement on high-grade glioma management in adults. The present report summarizes key highlights from the above clinical forum.
A case of Cornelia de Lange syndrome from Sudan
Authors: Mona Ellaithi, David Gisselsson, Therese Nilsson, Atif Elagib, Imad Fadl-Elmula, Mashair Abdelgadir
Journal: BMC Pediatr (2007)
MeSH terms: De Lange Syndrome / diagnosis, Developmental Disabilities / diagnosis, Malnutrition / diagnosis, Case Reports, Research Support, Non-U.S. Gov't, De Lange Syndrome / genetics, Developing Countries, Developmental Disabilities / genetics, Diagnosis, Differential, Female, Humans, Infant, Sudan

Background:
Brachmann de Lange syndrome (BDLS) is a multiple congenital anomaly syndrome characterized by a distinctive facial appearance, prenatal and postnatal growth deficiency, psychomotor delay, behavioral problems, and malformations of the upper extremities.
Case presentation:
Here we present for the first time a case of BDLS from Sudan, a 7-month-old female infant, who was referred as a case of malnutrition. The patient was from a Sudanese western tribe. Clinical investigation showed that the child was a classical case of BDLS, but with some additional clinical findings not previously reported including crowded ribs and tied tongue.
Conclusion:
Reporting BDLS cases of different ethnic backgrounds could add nuances to the phenotypic description of the syndrome and be helpful in diagnosis.
Medication-Related Osteonecrosis of the Jaw (MRONJ) due to Simvastatin: An Unusual Case Report
Authors: Sahand Samieirad, Ali Labafchi, Khashyar Famili, Haleh Hashemzadeh
Journal: World J Plast Surg (2021)
Keywords: bisphosphonate-related, osteonecrosis of the jaw, simvastatin
MeSH terms: Case Reports

Medication-related osteonecrosis of the jaw (MRONJ) is a serious pathological condition that usually results from anti-resorptive or anti-angiogenic drugs. We aimed to report an unusual MRONJ in a female patient due to long-term simvastatin administration. A 48-year female was referred to the Department of Oral and Maxillofacial, Mashhad Dental School, Mashhad, Iran in Dec 2019. She complained of pain, swelling, and infection in the right mandibular area with a history of extraction. Based on medical history, the patient received 40 mg of simvastatin daily for ten years to control hypercholesterolemia. According to clinical and radiographic examinations, as well as previous medical and dental records, the lesion diagnosis was detected as MRONJ. Moreover, histopathological examination of the lesion confirmed our clinical diagnosis. The necrotic bone was removed with caution. The PRF was then inserted, and the flap was sutured without any tension. No complications were observed on following-up, and all symptoms were discontinued. There was a correlation between the administration of high-dose simvastatin and MRONJ. Moreover, more clinical investigation with larger sample sizes is suggested.
Preoperative diagnosis of bicipitoradial bursitis: a case report
Authors: Asim Saleh Aldhilan
Journal: Pan Afr Med J (2014)
Keywords: bicipitoradial bursitis, mri, bursa, elbow pain
MeSH terms: Bursitis / diagnosis, Elbow Joint / pathology, Case Reports, Bursitis / complications, Diagnosis, Differential, Edema / diagnosis, Edema / etiology, Female, Humans, Middle Aged, Preoperative Period

Inflammation of the bicipitoradial bursa is a rare condition and only few reports can be found in literature. Several causes for a cubital bursitis have been suggested in the past. The need to include a malignant lesion in the differential diagnosis has only been mentioned in one of these reports. May main objective in reporting this case is to make this pathological entity better known.
Ewing's Sarcoma of the Zygomatic Arch Presenting in a 69-Year Old: An Unusual Case Report
Authors: Joanna C Mennie, Robin Reid, Fiona Cowie, Omar Hilmi
Journal: Case Rep Otolaryngol (2011)
MeSH terms: Case Reports

Objective. We report a rare case of Ewing's sarcoma of the zygomatic arch presenting in a 69-year-old patient. Method. Case report and a review of the world literature on Ewing's sarcoma incidence and management. Results. Ewing's sarcoma is a malignant round cell tumour of neuroectodermal origin that typically presents in the pelvis and long bones of children and adolescent boys. This report is the first to document the presentation of ewing's sarcoma of the zygomatic arch in a 69-year-old lady. Our patient underwent surgical excision and radiotherapy and at 4-year followup has no signs of recurrence or metastasis. Conclusion. To our knowledge this is the first case report to document Ewing's sarcoma of this location in a 69-year-old patient. This case report highlights the importance of diagnostic investigations in Ewing's sarcoma and discusses the management issues that this rare presentation raises.
The masquerades of a childhood ciliary body medulloepithelioma: a case of chronic uveitis, cataract, and secondary glaucoma
Authors: Jocelyn Chua, Wisam J Muen, Ashwin Reddy, John Brookes
Journal: Case Rep Ophthalmol Med (2012)
MeSH terms: Case Reports

Ciliary body medulloepitheliomas in childhood often masquerade other intraocular conditions due to its insidious nature as well as its secondary effects on proximal intraocular tissues in the anterior chamber. We report a case where a ciliary body medulloepithelioma in a two-year-old boy presents with chronic uveitis, cataract, and an uncontrolled secondary glaucoma after an innocuous blunt ocular trauma. The diagnosis was only made after the occurrence of a ciliary body mass. We discuss the clinical features of ciliary body medulloepitheliomas, the implications of a delayed diagnosis and treatment as well as the concern of periorbital tumor seeding with the use of an aqueous shunt implant in this case.
Different uptake patterns of 68Ga-FAPI in aseptic loosening and periprosthetic joint infection of hip arthroplasty: A case series and literature review
Authors: Yiqun Wang, Ruimin Wang, Lei Geng, Qingxiao Li, Erpeng Qi, Yuanyuan Shi, Yanmei Wang, Qingyuan Zheng, Guoqiang Zhang, Jiying Chen, Jiahe Tian
Journal: Front Med (Lausanne) (2022)
Keywords: 68ga-fapi, pet/ct, arthroplasty, case report, hip, image analysis
MeSH terms: Case Reports

Background:
The diagnosis of a periprosthetic joint infection (PJI) is always a difficult point in research on the surgery of joints. The current diagnostic criteria include a comprehensive analysis of multiple tests; however, there are no effective visual examinations yet that can differentiate between aseptic loosening and the PJI.
Case presentation:
This case report describes four patients with symptomatic total hip arthroplasty (THA), two cases of loosening and two cases of infection. Although the four cases were correctly diagnosed by the tissue culture, preoperative tests and pathological examination could not effectively distinguish an infection from a non-infection. Based on a preclinical study and theoretical feasibility, gallium-68 (68Ga)-labeled fibroblast activation protein inhibitor positron emission tomography/computed tomography (68Ga-FAPI PET/CT) was performed. Through 68Ga-FAPI PET/CT scanning, not only were the causes diagnosed correctly but the lesions were also located.
Conclusion:
When the lesion is located between the bone and the prosthesis, 68Ga-FAPI PET/CT could differentiate aseptic loosening from periprosthetic joint infection (PJI). 68Ga-FAPI PET/CT has clear advantages over routine examinations and has a prospective application in detecting PJI.
Regeneration of Pancreatic β-Islet Cells in a Type-II Diabetic
Authors: Edwin C Jones, J Craig Rylands, Cortney L Jardet
Journal: Case Rep Endocrinol (2018)
MeSH terms: Case Reports

A case report is presented in which a type-II diabetic patient significantly improved his dysfunctional β-islet cells using a combination of a strenuous exercise program, cyclical ketogenic diet, and oral GABA/probiotic supplementation. The patient was diagnosed with type-II diabetes at the age of 41 which then progressed through a typical series of treatment changes over 14 years. Treatment periods consisted of metformin therapy alone for 4 years followed by a metformin/glyburide combination therapy for 6 years, and eventually an insulin/metformin combination therapy for 4 years. One year after the initiation of insulin, the patient increased the level of strenuous physical activity (hiking and weight lifting) and adopted a ketogenic diet. Oral GABA and probiotic supplementation were also initiated at the age of 52.7. By the age of 55, the patient no longer required any insulin and is currently being managed with metformin alone. C-peptide values indicate a functional improvement of the β-islet cells during the time of insulin/GABA/probiotic treatment.
Primary pleural angiosarcoma in a 63-year-old gentleman
Authors: Ahmed Abu-Zaid, Shamayel Mohammed
Journal: Case Rep Pulmonol (2013)

Primary pleural angiosarcomas are extremely rare. As of 2010, only around 50 case reports have been documented in the literature. Herein, we report the case of a 63-year-old gentleman who presented with a 3-month history of right-sided chest pain, dyspnea, and hemoptysis. Chest X-ray showed bilateral pleural effusion with partial bibasilar atelectasis. Ultrasound-guided thoracocentesis showed bloody and exudative pleural fluid. Cytologic examination was negative for malignant cells. An abdominal contrast-enhanced computed tomography (CT) scan showed two right diaphragmatic pleural masses. Whole-body positron emission tomography/computed tomography (PET/CT) scan showed two hypermetabolic fluorodeoxyglucose- (FDG-) avid lesions involving the right diaphragmatic pleura. CT-guided needle-core biopsy was performed and histopathological examination showed neoplastic cells growing mainly in sheets with focal areas suggestive of vascular spaces lined by cytologically malignant epithelioid cells. Immunohistochemical analysis showed strong positivity for vimentin, CD31, CD68, and Fli-1 markers. The overall pathological and immunohistochemical features supported the diagnosis of epithelioid angiosarcoma. The patient was scheduled for surgery in three weeks. Unfortunately, the patient died after one week after discharge secondary to pulseless ventricular tachycardia arrest followed by asystole. Moreover, we also present a brief literature review on pleural angiosarcoma.
Successful Treatment of Klebsiella pneumoniae Harboring a Klebsiella pneumoniae Carbapenemase Isolated from Lumbar Wound Infection and Blood in a Patient with Hardware Retention
Authors: Alan Bulbin, Carol Bono, Tena Philp, Noriel Mariano, Carl Urban
Journal: Case Rep Infect Dis (2017)
MeSH terms: Case Reports

Infections caused by carbapenem-resistant Enterobacteriaceae, especially carbapenemase producing Klebsiella pneumoniae, represent an urgent threat as outlined by the Centers for Disease Control and Prevention (CDC). We present a 66-year-old male with spinal stenosis who underwent elective L2-pelvis posterior spinal fusion at an outside institution and rapidly developed a complicated infection with Klebsiella pneumoniae harboring Klebsiella pneumoniae carbapenemase. This is the first described case of a patient with Klebsiella pneumoniae harboring Klebsiella pneumoniae carbapenemase causing postoperative lumbar wound infection and bacteremia, successfully treated with ceftazidime-avibactam in combination with additional synergistic antibacterials and without hardware removal.
Psychotherapy with a 3-Year-Old Child: The Role of Play in the Unfolding Process
Authors: Silvia Salcuni, Daniela Di Riso, Diana Mabilia, Adriana Lis
Journal: Front Psychol (2017)
Keywords: child, play, process-outcome research, psychodynamic psychotherapy, single case study, verbal productivity

Few studies have investigated the outcomes and process of psychodynamic psychotherapies with children. Among the limited number of studies, some only paid attention to play and verbal production, as they are fundamental aspects in assessing the psychotherapy process. This paper focuses on an empirical investigation of a 3-year, once-a-week psychodynamic psychotherapy carried out with a 3-year-old girl. A process-outcome design was implemented to evaluate play and verbal discourse in in the initial, middle, and final parts of 30 psychotherapy sessions. Repeated measurements of standardized play categories (the Play Category System and the Affect in Play Scale-Preschool version) and verbal discourse (Verbal Production) were analyzed. To increase the clinical validity of the study, data from the assessment phase and vignettes from the sessions were reported to deepen the patient's picture during the unfolding therapy process. Parent reports before and after the therapy were also included. Empirically measured changes in play and verbal production were fundamental in evaluating the young patient's psychotherapy process. Verbal production and discourse ability progressively increased and took the place of play, which instead became more symbolic. Developmental issues as well as psychotherapy's influence on the patient's change, were discussed in relation to the role of play in enhancing the development of verbal dialog and the expression of the child's emotions, needs, and desires.
Same Gender Erotomania: When the Psychiatrist Became the Delusional Theme-A Case Report and Literature Review
Authors: Ruzita Jamaluddin
Journal: Case Rep Psychiatry (2021)
MeSH terms: Case Reports

Erotomania is a rare subtype of delusional disorder, whereby the affected person believes that another individual, usually someone with higher socio-economic status, is in love with them despite having little or no contact. To the best of our knowledge, this is the first published case of same gender erotomania, involving a 28-year-old single lady and a 42-year-old divorcee towards a female psychiatrist. We aimed to share the challenges experienced by the managing psychiatrist as she inopportunely became the theme of her patients' delusion. We also reviewed and discussed recent literature on erotomania to create awareness among psychiatrists towards this rare psychiatric condition.
Bioterrorism-related inhalational anthrax in an elderly woman, Connecticut, 2001
Authors: Kevin S Griffith, Paul Mead, Gregory L Armstrong, John Painter, Katherine A Kelley, Alex R Hoffmaster, Donald Mayo, Diane Barden, Renee Ridzon, Umesh Parashar, Eyasu Habtu Teshale, Jennifer Williams, Stephanie Noviello, Joseph F Perz, Eric E Mast, David L Swerdlow, James L Hadler
Journal: Emerg Infect Dis (2003)
MeSH terms: Anthrax / etiology, Bioterrorism, Inhalation Exposure, Case Reports, Aged, Anthrax / diagnosis, Anthrax / drug therapy, Anthrax / epidemiology, Bacillus anthracis / genetics, Bacillus anthracis / isolation & purification, Connecticut / epidemiology, DNA, Bacterial / analysis, Disease Outbreaks / statistics & numerical data, Environmental Exposure, Female, Humans, Postal Service, Sentinel Surveillance, Spores, Bacterial / isolation & purification, Time Factors, DNA, Bacterial

On November 20, 2001, inhalational anthrax was confirmed in an elderly woman from rural Connecticut. To determine her exposure source, we conducted an extensive epidemiologic, environmental, and laboratory investigation. Molecular subtyping showed that her isolate was indistinguishable from isolates associated with intentionally contaminated letters. No samples from her home or community yielded Bacillus anthracis, and she received no first-class letters from facilities known to have processed intentionally contaminated letters. Environmental sampling in the regional Connecticut postal facility yielded B. anthracis spores from 4 (31%) of 13 sorting machines. One extensively contaminated machine primarily processes bulk mail. A second machine that does final sorting of bulk mail for her zip code yielded B. anthracis on the column of bins for her carrier route. The evidence suggests she was exposed through a cross-contaminated bulk mail letter. Such cross-contamination of letters and postal facilities has implications for managing the response to future B. anthracis-contaminated mailings.
New onset asthma during pregnancy: two case reports
Authors: Paula S Schriek, Saar A Bendien, Hanneke A Feitsma, Jeroen van Exsel
Journal: F1000Res (2023)
Keywords: asthma, exacerbation, infection, pregnancy
MeSH terms: Asthma / diagnosis, Case Reports, Diagnosis, Differential, Eosinophils, Female, Humans, Infant, Newborn, Mothers, Pregnancy, Respiratory Syncytial Viruses

Asthma is the most common chronic respiratory disease during pregnancy. However, reports of new onset asthma during pregnancy are lacking. We report two cases of new onset asthma during pregnancy following respiratory tract infection, subsequently one case with M. pneumoniae infection and the other case with a combined infection with respiratory syncytial virus and rhinovirus. Case presentation: Both patients presented with the clinical features of an acute asthma exacerbation during pregnancy without a medical history of asthma. During follow up the diagnosis of asthma was supported by spirometry showing significant reversibility and elevated fractional exhaled nitric oxide (FeNO). Patients were hospitalized and received supplemental oxygen, treatment for an acute asthma exacerbation with systemic corticosteroids, high dose inhalation therapy. These therapeutic interventions subsequently led to a good outcome for the mother and newborn in both cases. Conclusions: New onset asthma should be part of the differential diagnosis in pregnant patients with respiratory symptoms, particularly in case of mycoplasma infection. Diagnosing asthma during pregnancy can be challenging. In these circumstances, additional diagnostic tests (like inflammatory biomarkers FeNO and blood eosinophils) can be helpful to support the diagnosis.
Contrecoup epidural hematoma: a rare case report
Authors: Farhad Bal'afif, Donny Wisnu Wardhana, Tommy Nazwar Alfandy, Ariel Jesse
Journal: Pan Afr Med J (2022)
Keywords: contrecoup, case report, dura, epidural hematoma
MeSH terms: Craniocerebral Trauma / complications, Craniocerebral Trauma / surgery, Hematoma, Epidural, Cranial / diagnosis, Hematoma, Epidural, Cranial / etiology, Hematoma, Epidural, Cranial / surgery, Skull Fractures / complications, Skull Fractures / diagnosis, Skull Fractures / surgery, Case Reports, Adult, Craniotomy, Humans, Male, Tomography, X-Ray Computed / adverse effects

Epidural hematoma (EDH) is defined as a traumatic accretion of blood separating the dural membrane and the internal table of the skull that caused from contact bending or skull fracture. The cases of contrecoup EDH are as not common, and there are just 10 recorded cases on this. As a result of its uncommonness, we disclose one subject of a 33-year-old man having countrecoup EDH who suffered from a head trauma caused by falling from 4 meters high. The main symptoms were decreasing consciousness and vomiting. Clinical findings showed a Glasgow Coma Scale score of 9, laceration in the left parietal region with stable hemodynamic. Head Computed tomography showed a large EDH in the right frontal and temporal region with coronal suture diastasis. The patient immediately underwent surgery, and craniotomy with evacuation of extradural hematoma were performed. This case presents that a force, which creates an angle, can propagates and causes opposite coronal suture diastasis and makes contrecoup EDH.
Rosai-Dorfman disease of the breast
Authors: C K E Parkin, C Keevil, M Howe, A J Maxwell
Journal: BJR Case Rep (2015)
MeSH terms: Case Reports

A 56-year-old female was recalled for assessment following screening mammography that demonstrated a new 9-mm indeterminate density in the left breast. Clinical breast examination was normal. Ultrasound confirmed a 9-mm predominantly well-defined hypoechoic breast mass. Core biopsy demonstrated large histiocytes with emperipolesis and positive staining for S100, which is consistent with Rosai-Dorfman disease (RDD). Multidisciplinary team discussion concluded case concordance. The patient was discharged back to the screening programme. RDD is a rare, benign condition that may mimic breast cancer. This case demonstrates that identification of RDD on core needle biopsy may help avoid unnecessary surgery.
Repeated Endovascular Treatment of Early Recurrent Proximal Middle Cerebral Artery Occlusion: Case Report and Brief Review of the Literature
Authors: Simon Fandler, Hannes Deutschmann, Franz Fazekas, Thomas Gattringer
Journal: Front Neurol (2018)
Keywords: endovascular treatment, ischemic stroke, large vessel occlusion, recurrent stroke, stroke, thrombectomy
MeSH terms: Case Reports

Mechanical thrombectomy (MT) is the gold standard treatment for large vessel occlusion (LVO) stroke of the anterior circulation. Whether MT can also be effectively and safely performed in early recurrent LVO is largely unclear. We present the case of a middle-aged patient who was successfully treated by MT for right proximal middle cerebral artery (MCA) occlusion with excellent outcome. One day after discharge (9 days after the first MT), the patient was readmitted with wake-up stroke. MRI again revealed right proximal MCA occlusion with severe diffusion-perfusion mismatch. Repeat MT was performed and once more led to almost full recovery. The recurrent strokes were attributed to ulcerated non-stenosing plaques in the ipsilateral internal carotid artery, which prompted thromboendarterectomy. In an 18-months follow-up period, no further vascular events occurred. In conclusion, repeated MT for early recurrent LVO appears feasible in carefully selected patients. The collection of similar cases via registries would be desirable.