OpenMed/multicare-articles huggingface dataset:
Case report: Non-Alzheimer's disease tauopathy with logopenic variant primary progressive aphasia diagnosed using amyloid and tau PET
Authors: Yuki Momota, Mika Konishi, Keisuke Takahata, Taishiro Kishimoto, Toshiki Tezuka, Shogyoku Bun, Hajime Tabuchi, Daisuke Ito, Masaru Mimura
Journal: Front Neurol (2022)
Keywords: alzheimer's disease, frontotemporal lobar degeneration, logopenic variant, positron emission tomography, primary progressive aphasia, tauopathy
MeSH terms: Case Reports

We report a patient with logopenic variant primary progressive aphasia (lv-PPA) who was diagnosed as having non-Alzheimer's disease (AD) tauopathy after multiple biophysical/biological examinations, including amyloid and 18F-florzolotau tau positron emission tomography (PET), had been performed. A woman in her late 60s who had previously been diagnosed as having AD was referred to us for a further, detailed examination. She had been unaware of any symptoms at the time of AD diagnosis, but she subsequently became gradually aware of a speech impairment. She talked nearly completely and fluently, although she occasionally exhibited word-finding difficulty and made phonological errors during naming, word fluency testing, and sentence repetition; these findings met the criteria for the diagnosis of lv-PPA, which is known to be observed more commonly in AD than in other proteinopathies. Magnetic resonance imaging, single photon emission computed tomography, and plasma phosphorylated tau and plasma neurofilament light chain measurements showed an AD-like pattern. However, both 11C-Pittsburgh compound-B and 18F-florbetaben amyloid PET showed negative results, whereas 18F-florzolotau tau PET yielded positive results, with radio signals predominantly in the left superior temporal gyrus, middle temporal gyrus, supramarginal gyrus, and frontal operculum. Whole-genome sequencing revealed no known dominantly inherited mutations in AD or frontotemporal lobar degeneration genes, including the genes encoding amyloid precursor protein, microtubule-associated protein tau, presenilin 1 and 2. To the best of our knowledge, this patient was a rare case of lv-PPA who was diagnosed as having non-AD tauopathy based on the results of multiple examinations, including whole-genome sequencing, plasma measurement, and amyloid and 18F-florzolotau tau PET. This case underscores the clinicopathologically heterogeneous nature of this syndrome.
A Glass Fiber-Reinforced Resin Composite Splint to Stabilize and Replace Teeth in a Periodontally Compromised Patient
Authors: Angelika Rauch, Sebastian Mehlhorn, Manja Mühle, Dirk Ziebolz
Journal: Case Rep Dent (2020)
MeSH terms: Case Reports

Combined periodontal and prosthodontic treatment demands of patients require a structured coordination of pretreatments and an adequate choice of restorations. This is especially true if multiple teeth are missing and insufficient crown-root ratios are obvious. A 40-year-old patient with a severe periodontitis (Stage IV, Grade C) was treated with active, nonsurgical periodontal therapy. Afterwards, a supportive periodontal therapy was provided with a recall interval of three to four months. Due to a high tooth mobility of the anterior teeth in the upper jaw and a missing left canine, a combination of a resin composite (Signum composite, Kulzer, Hanau, Germany) and a unidirectional glass prepreg fiber (Tender Fiber Quattro, MICERIUM, Avegno, Italy) was utilized to fabricate a splint in a labside approach to stabilize the remaining teeth. Moreover, an artificial denture tooth was adhesively luted to the splint. A temporary polymer-based material (Vita CAD-Temp, VITA Zahnfabrik, Bad Säckingen, Germany) was selected to supply the posterior teeth of the patient with a 3-unit fixed dental prosthesis (FDP), and both restorations were adhesively cemented. 19 months after insertion, a fracture of the fiber-reinforced resin composite splint occurred that was intraorally repaired. In spite of the fracture of the splint, all materials were functionally and esthetically stable over the follow-up period of 22 months.
Conventional Treatment of Maxillary Incisor Type III Dens Invaginatus with Periapical Lesion: A Case Report
Authors: Alvaro Henrique Borges, Alex Semenoff Segundo, Michele Regina Nadalin, Fábio Luís Miranda Pedro, Antônio Miranda da Cruz Filho, Manoel Damião Sousa-Neto
Journal: ISRN Dent (2011)
MeSH terms: Case Reports

Dens invaginatus is a developmental dental anomaly clinically characterized by a palatine furrow that can be limited to the coronal pulp or may extend to the radicular apex. The purpose of this paper was to present a clinical case of type III dens invaginatus, identified on the maxillary right central incisor in anterior periapical radiographs, in which the tooth was submitted to conventional endodontic treatment. The results obtained after five years of clinical and radiographic followup demonstrated that conventional endodontic treatment is a clinically viable alternative in cases of type III dens invaginatus.
Primary Renal Lymphoma Identified in a Robot-Assisted Laparoscopic Nephroureterectomy Specimen
Authors: Jacob Jipp, Daniel Sadowski, Paul Kay, Bradley Schwartz
Journal: J Endourol Case Rep (2016)
MeSH terms: Case Reports

Background:
Although renal involvement is often present in non-Hodgkin's lymphoma (NHL), primary renal NHL is a rare diagnosis.
Case presentation:
We present a case report of a 72-year-old asymptomatic male who underwent a robot-assisted laparoscopic radical nephroureterectomy on an atrophic left kidney with evidence of an infiltrating mass. Pathology report demonstrated a grade 1 follicular lymphoma.
Conclusion:
Lymphoma is a differential that should be considered when evaluating a renal mass. Chemotherapy and radiation are the mainstays of treatment.
Case Report: Analysis of four cases of metastatic bladder masses after radical prostatectomy
Authors: Hao Wang, Dawei Xie, Jun Lu, Yifan Chu, Siqi Wang, Peng Qiao, Liyang Wu, Jianwen Wang
Journal: Front Oncol (2023)
Keywords: bladder metastasis, diagnosis, prognosis, prostate cancer, radical prostatectomy
MeSH terms: Case Reports

Objective:
The aim of this study is to investigate the clinical characteristics and diagnostic and therapeutic methods of bladder metastasis after radical prostatectomy and to improve its diagnosis and treatment.
Methods:
The clinical data of four patients with bladder metastasis after radical prostatectomy were retrospectively analyzed from January 2011 to December 2021. Three cases suffered from intermittent gross hematuria, and only one case was found to have an elevated prostate-specific antigen (PSA) value. Transurethral resection of bladder tumor was performed in four cases, in which one case also underwent resection of urethral mass. Three cases received endocrine therapy, one of which added intravesical instillation and radiation therapy. Another case received chemotherapy based on comprehensive treatment.
Results:
According to the pathological and immunohistochemical results, three cases were acinar adenocarcinoma of the prostate with Gleason score of 9, and all cases were PSA positive and negative for cytokeratin 7 (CK7) and GATA binding protein 3 (GATA-3). One case was small cell neuroendocrine carcinoma of the prostate and was positive for chromogranin A (CGA), synaptophysin (SYN), and cluster of differentiation 56 (CD56). During the follow-up period of 4 to 13 months, one case was lost to follow-up and three cases were alive.
Conclusion:
Bladder metastasis after radical prostatectomy is rare, and pathology combined with immunohistochemistry is the gold standard for its diagnosis. Pathological type determines its treatment. Systemic treatment is essential, and local treatment is the most palliative means. Early diagnosis and treatment is significant for better prognosis.
Clinical challenges of primary diffuse large B-cell lymphoma of the dura: case report and literature review
Authors: Rabih Said, Sanaa Rizk, Qun Dai
Journal: ISRN Hematol (2011)
MeSH terms: Case Reports

Primary dural lymphoma is a rare disease with more indolent clinical behavior compared to primary central nervous system lymphoma. The majority of the reported cases were indolent marginal zone lymphoma subtype with more predilections to the spine. Herein, we are presenting a case of intracranial, diffuse large B-cell lymphoma of the dura that was diagnosed and treated at our institution. We are presenting the challenges in the treatment based on a review of the literature.
Case report: An elderly woman with recurrent syncope after pacemaker implantation
Authors: Yanxiang Sun, Li Feng, Xuansheng Huang, Bing Hu, Yong Yuan
Journal: Front Cardiovasc Med (2023)
Keywords: electrophysiology phenomenon, loss of capture, permanent pacemaker implantation, pulmonary embolism, syncope
MeSH terms: Case Reports

Syncope caused by atrioventricular block may occur as a result of a cardiac vasodepressor reflex. This article reports on a case of recurrent syncope in an 80-year-old woman with high-grade atrioventricular block, documented by electrocardiographic monitoring after pacemaker implantation. Pacemaker testing revealed stable impedance and sensing but a clear increase in the ventricular capture threshold at outputs. This case is unusual because the patient's primary diagnosis was non-cardiac. However, a combination of high D-dimer, hypoxemia, and computerized tomography scan of the pulmonary artery confirmed the diagnosis of pulmonary embolism (PE). With 1 month of anticoagulant therapy, the ventricular capture threshold gradually dropped to the normal range and syncope resolved. This is the first report of an electrophysiological phenomenon detected by pacemaker testing in a patient with syncope arising from PE.
Ventral Longitudinal Intraspinal Fluid Collection in Patients with Cervical Disc Herniation: A Report of Two Cases
Authors: Rui Hirasawa, Takashi Itabashi, Tsuneji Kita, Chikato Mannoji
Journal: Case Rep Orthop (2020)
MeSH terms: Case Reports

We encountered two cases of cervical disc herniation, wherein cerebrospinal fluid collection in the ventral epidural space between the cervical spine and the thoracic spine was noted. The patients, two women aged 71 and 43 years, were diagnosed with cervical disc herniation and underwent anterior cervical discectomy and fusion. Unexpected cerebrospinal fluid leakage was observed prior to exposure of the dura mater. Notably, the dura mater was intact following the removal of the herniated disc in both cases. No cerebrospinal fluid leakage symptoms were observed, and relief from the neurological symptoms related to the cervical disc herniation was observed in both cases following the surgery. Findings of preoperative magnetic resonance imaging and computed tomography myelography were carefully reviewed, retrospectively. Both patients presented with similar features including expansion of cerebrospinal fluid collection in the ventral epidural space between the cervical spine and the thoracic spine. These observed features were similar to those of superficial siderosis, which is a form of duropathy-a disease caused by dural defects. Therefore, the patients in this case study might have a subclinical duropathy with associated cervical disc herniation.
Case report: Autoimmune encephalitis with multiple auto-antibodies with reversible splenial lesion syndrome and bilateral ovarian teratoma
Authors: Yaqiang Li, Mei Zhang, Deshun Liu, Ming Wei, Jun Sheng, Zhixin Wang, Song Xue, Tingting Yu, Weimin Xue, Beibei Zhu, Jiale He
Journal: Front Immunol (2023)
Keywords: anti-n-methyl-d-aspartame receptor (anti-nmdar) encephalitis, anti-metabotropic glutamate receptor 5 (mglur5) encephalitis, autoimmune encephalitis, ovarian teratomas, reversible splenial lesion syndrome
MeSH terms: Anti-N-Methyl-D-Aspartate Receptor Encephalitis / therapy, Ovarian Neoplasms / complications, Ovarian Neoplasms / diagnosis, Teratoma / complications, Teratoma / diagnosis, Case Reports, Adult, Antibodies, Female, Humans, Antibodies, Hashimoto's encephalitis, Teratoma, Ovarian

Background:
Reversible splenial lesion syndrome (RESLES) is a spectrum of disease radiologically characterized by reversible lesions caused by multiple factors, primarily involving the splenium of the corpus callosum (SCC). The most common causes of RESLES include infection, antiepileptic drug use and withdrawal, and severe metabolic disorders. Nevertheless, cases of autoimmune encephalitis (AE) are uncommon.
Case presentation:
A 26-year-old female computer programming engineer with no previous medical or psychiatric history reported to the psychiatric hospital due to a 3-day episode of irritability, babbling, limb stiffness, sleepwalking, hallucinations, and paroxysmal mania. Brain MRI revealed abnormal signals of the SCC. Lumbar puncture was performed and further testing for auto-antibodies was conducted in both the CSF and serum. CSF of the patient was positive for anti-NMDAR (titer of 1:3.2) antibodies, and serum was also positive for anti-NMDAR (titer of 1:32) as well as mGluR5 (titer of 1:10) antibodies. Enhanced CT of the pelvis showed an enlarged pelvic mass; bilateral ovarian teratomas (mature teratoma and immature teratoma) were evaluated, which were pathologically confirmed after transabdominal left adnexal resection, right ovarian biopsy, and ovarian cystectomy. The patient considerably improved after intravenous administration of steroids, immunoglobulin, oral prednisone, surgical treatment, and chemotherapy. A follow-up MRI revealed completely resolved lesions. During a 3-month follow-up, the patient experienced complete resolution of symptoms without any sign of recurrence and tumors. The titer of the anti-NMDAR antibody decreased to 1:10 in serum.
Conclusion:
Herein, we report a rare case of AE with overlapping auto-antibodies, along with RESLES and bilateral ovarian teratomas. The current case provides the possibility of the concurrence of mGluR5 antibodies in anti-NMDAR encephalitis. However, the underlying mechanism remains elusive. Furthermore, we provide additional evidence that overlapping antibodies-related pathology may be one of the many causes of RESLES. Nonetheless, caution should be observed in interpreting the observation, considering that this is a single-case study.
A case of apical ballooning syndrome in a male with status asthmaticus; highlighting the role of B2 agonists in the pathophysiology of a reversible cardiomyopathy
Authors: Farah F Salahuddin, Peter Sloane, Philip Buescher, Lev Agarunov, Divya Sreeramoju
Journal: J Community Hosp Intern Med Perspect (2013)
Keywords: cardiology, medicine, pulmonary critical care
MeSH terms: Case Reports

Apical ballooning syndrome (ABS), also known as Takotsubo cardiomyopathy, was first reported by Dote and colleagues in Japanese literature in 1991 in a review of five cases. Case series have highlighted the association of severe psychological stressors as the major precipitating factors of this syndrome. Status Epilepticus and Sub-Arachnoid hemorrhage are also now established independent etiologies for this phenomenon in patients without coronary artery disease. We report a case of reversible apical ventricular dysfunction in a 50-year-old male presenting with status asthmaticus who quickly underwent intubation. Following this, he had ST elevations in precordial leads with mild cardiac enzyme leak. Subsequent cardiac catheterization revealed a left ventricular ejection fraction of 25-30% with apical aneurismal segment. No obstructive disease was observed. Three days later there was marked clinical improvement; the patient was extubated and repeat echocardiography revealed a remarkable return to normal ventricular size and systolic function. Our case demonstrates that excess use of beta-agonists may be a potential risk factor for ABS and raises the possibility of cathecholamine cardiotoxicity being mediated via beta-receptors. Furthermore, it also negates the propensity of apical ballooning so far reported only in women with respiratory distress without confounding emotional stressors.
Management of Postsurgical Complication in Multiple Implant-Infected Postextraction Sites in the Lower Arch
Authors: Frank Mayta-Tovalino, José Rosas, Cesar Mauricio-Vilchez, Silvia Luza, Daniel Alvitez-Temoche, Franco Mauricio
Journal: Int J Dent (2020)
MeSH terms: Case Reports

Currently, dental implants are a very frequent therapeutic alternative for replacing missing teeth. However, they are not exempt from developing complications of infectious origin. Therefore, this case report describes a 67-year-old female patient presenting infectious complications caused by suture rupture. Surgery combined with therapeutic management with antibiotics was performed, allowing preservation of the osseointegration of the implants in the lower arch. Within the limitations of this study, it was shown that more research is needed to determine the success and survival of implants presenting complications due to infections during the osseointegration process.
Case Report: Metastatic Parosteal Osteosarcoma in a Dog
Authors: Sarah K Samuels, Matthew R Cook, Eric Green, Ryan Jennings, Roy R Pool, Vincent A Wavreille, William C Kisseberth, Laura E Selmic
Journal: Front Vet Sci (2021)
Keywords: bone tumor - osteosarcoma, canine (dog), metastases, osteosarcoma - pathology, parosteal or juxtacortical variant
MeSH terms: Case Reports

This case report describes a rare form of malignant bone tumor in an 8-year-old Labrador retriever. This dog initially presented for evaluation of a right distal humeral mass. Radiographs of the right elbow and thorax were performed, revealing a smooth mineralized mass adjacent to the lateral aspect of the distal humerus and a 5mm pulmonary nodule. Computed tomography (CT) of the humerus and thorax showed a smooth mineralized lesion adjacent to the lateral humeral epicondyle, and a right cranial lung lobe nodule with a thin mineral rim. Surgical biopsies of both lesions were diagnostic for parosteal osteosarcoma (POSA). The dog was then treated with stereotactic body radiation therapy (SBRT) which controlled the dog's discomfort for 14 months until he became progressively painful and subsequently had his right forelimb amputated. This case report is the first to document the CT imaging characteristics of a metastatic appendicular POSA in a dog and the first dog described with POSA treated with SBRT. The dog lived for 623 days after histopathologic diagnosis and 849 days after initial presentation with pulmonary metastatic disease.
Giant Brunner's Gland Adenoma Presenting as Upper Gastrointestinal Bleeding in 76 Years Old Male: A Case Report
Authors: Ramesh Rana, Rikesh Sapkota, Bishal Kc, Anish Hirachan, Bimas Limbu
Journal: JNMA J Nepal Med Assoc (2019)
MeSH terms: Adenoma / diagnosis, Brunner Glands / pathology, Duodenal Neoplasms / diagnosis, Gastrointestinal Hemorrhage / etiology, Case Reports, Adenoma / pathology, Aged, Duodenal Neoplasms / pathology, Endoscopy, Digestive System, Humans, Male, Vomiting / etiology

Brunner's gland adenoma is a rare benign tumor of small bowel, often incidentally discovered during endoscopy or radiological imaging. Mostly they are asymptomatic or often present with nonspecific symptoms such as nausea, vomiting, gastrointestinal hemorrhage, iron deficiency anemia. We reported a 76 years old male case presented with chief complaints of vomiting and black tarry stool. General physical examination was normal except mild tenderness over epigastrium. Esophagogastroduodenoscopy revealed a pedunculated polypoid tubular structure with blind end distally of length approximately 10-12* 3.5*1.5 cm in the second section of the duodenum with multiple skipped ulcers on the exposed surface of it. Additionally, there were few erosions in the duodenum proximally and multiple superficial ulcerations in the antrum, associated with helicobacter pylori confirmed by rapid urease test kit. Surgical or endoscopic excision is the treatment of choice. We consider our case is the eldest case among Brunner's gland adenoma case in literature. Keywords: Brunner's gland adenoma; Brunner's gland hamartoma; Brunner's gland hyperplasia; case report.
A disconcerting false gastric diverticulum mimicking malignancy
Authors: Dhouha Bacha, Asma Sassi, Seifeddine Baccouche, Ghofrane Talbi, Sana Ben Slama, Lassad Gharbi, Saadia Bouraoui, Ahlem Lahmar
Journal: Pan Afr Med J (2019)
Keywords: diverticulum, malignancy, stomach, surgery
MeSH terms: Diverticulum, Stomach / diagnosis, Gastrectomy / methods, Stomach Neoplasms / diagnosis, Case Reports, Aged, Diverticulum, Stomach / pathology, Diverticulum, Stomach / surgery, Humans, Male

Gastric diverticula are the most uncommon form of gastrointestinal diverticula. They can either be of true or false type with different pathogenesis. They may be very challenging to diagnose as symptoms are nonspecific and imaging can simulate a malignant lesion. We report an unusual case of pre-pyloric diverticulum in a 69-year-old man, leading to severe gastric obstruction with a poor general condition. As subsequent endoscopy and imaging were alarming and couldn't exclude malignancy, the patient underwent an antrectomy. The final diagnosis was made on pathological examination. We discuss, through this case, the clinical and pathological features of gastric diverticula with an emphasis on the pathogenesis of this rare entity and the risk of a malignant transformation.
Pyridostigmine induced heart block requiring ICU admission
Authors: Benjamin Chaucer, Dustin Whelan, Dronacharya Lamichhane
Journal: J Community Hosp Intern Med Perspect (2018)
Keywords: ekg, heart block, icu, myasthenia gravis, pyridostigmine
MeSH terms: Case Reports

Myasthenia gravis is an autoimmune disorder that effects an estimated 20 people per 100,000 in the USA per year. Pyridostigmine is a common drug used in the symptomatic treatment of myasthenia gravis. While generally safe and effective, a rare set of patients treated with pyridostigmine encounter cardiac conduction disorders. Here, we report a rare presentation of an adverse drug reaction due to pyridostigmine, which is important for its implications in the acute care setting.
Medical Management of Hemorrhagic Bowel Syndrome in a Beef Bull
Authors: Joe S Smith, Xueying Zhou, Paul T Merkatoris, Cassandra A Klostermann, Ryan M Breuer
Journal: Case Rep Vet Med (2019)
MeSH terms: Case Reports

A two and a half-year old Simmental bull was presented to Iowa State University's Food Animal and Camelid Hospital for anorexia and lethargy of several days. Clostridium perfringens type A was identified via fecal culture and toxin genotyping. Hemorrhagic bowel syndrome (HBS) was diagnosed based on microbiological results along with abdominal ultrasonography, complete blood count, and serum biochemistry. Aggressive multi-modal therapy was employed including intravenously administered fluid therapy, potassium penicillin, lidocaine, flunixin, and pantoprazole among other supportive care. The bull was discharged after 15 days of hospitalization and recovered uneventfully to full function by the next breeding season. Currently all case reports with regard to HBS in beef cattle describe mortality. While the dairy cattle literature demonstrates that HBS has a high mortality rate, and suggests that surgical intervention has a higher prognosis when compared to medical therapy in dairy cattle. Our case would provide support to aggressive medical treatment for HBS in beef cattle.