# Nummer 1-hits in de Billboard Hot 100 in 2000

Deze hits stonden in 2000 op nummer 1 in de Billboard Hot 100.
| Datum | Artiest | Titel |
| 1 januari | Santana & Rob Thomas | Smooth |
| 8 januari | Santana & Rob Thomas | Smooth |
| 15 januari | Christina Aguilera | What a girl wants |
| 22 januari | Christina Aguilera | What a girl wants |
| 29 januari | Savage Garden | I knew I loved you |
| 5 februari | Savage Garden | I knew I loved you |
| 12 februari | Savage Garden | I knew I loved you |
| 19 februari | Mariah Carey & Joe & 98 Degrees | Thank God I found you |
| 26 februari | Savage Garden | I knew I loved you |
| 4 maart | Lonestar | Amazed |
| 11 maart | Lonestar | Amazed |
| 18 maart | Destiny's Child | Say my name |
| 25 maart | Destiny's Child | Say my name |
| 1 april | Destiny's Child | Say my name |
| 8 april | Santana & The Product G&B | Maria Maria |
| 15 april | Santana & The Product G&B | Maria Maria |
| 22 april | Santana & The Product G&B | Maria Maria |
| 29 april | Santana & The Product G&B | Maria Maria |
| 6 mei | Santana & The Product G&B | Maria Maria |
| 13 mei | Santana & The Product G&B | Maria Maria |
| 20 mei | Santana & The Product G&B | Maria Maria |
| 27 mei | Santana & The Product G&B | Maria Maria |
| 3 juni | Santana & The Product G&B | Maria Maria |
| 10 juni | Santana & The Product G&B | Maria Maria |
| 17 juni | Aaliyah | Try again |
| 24 juni | Enrique Iglesias | Be with you |
| 1 juli | Enrique Iglesias | Be with you |
| 8 juli | Enrique Iglesias | Be with you |
| 15 juli | Vertical Horizon | Everything you want |
| 22 juli | Matchbox Twenty | Bent |
| 29 juli | 'n Sync | It's gonna be me |
| 5 augustus | 'n Sync | It's gonna be me |
| 12 augustus | Sisqó | Incomplete |
| 19 augustus | Sisqó | Incomplete |
| 26 augustus | Janet Jackson | Doesn't really matter |
| 2 september | Janet Jackson | Doesn't really matter |
| 9 september | Janet Jackson | Doesn't really matter |
| 16 september | Madonna | Music |
| 23 september | Madonna | Music |
| 30 september | Madonna | Music |
| 7 oktober | Madonna | Music |
| 14 oktober | Christina Aguilera | Come on over baby (All I want is you) |
| 21 oktober | Christina Aguilera | Come on over baby (All I want is you) |
| 28 oktober | Christina Aguilera | Come on over baby (All I want is you) |
| 4 november | Christina Aguilera | Come on over baby (All I want is you) |
| 11 november | Creed | With arms wide open |
| 18 november | Destiny's Child | Independent women part 1 |
| 25 november | Destiny's Child | Independent women part 1 |
| 2 december | Destiny's Child | Independent women part 1 |
| 9 december | Destiny's Child | Independent women part 1 |
| 16 december | Destiny's Child | Independent women part 1 |
| 23 december | Destiny's Child | Independent women part 1 |
| 30 december | Destiny's Child | Independent women part 1 |
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