# Nummer 1-hits in de Billboard Hot 100 in 1980

Deze hits stonden in 1980 op nummer 1 in de Billboard Hot 100.
| Datum | Artiest | Titel |
| 5 januari | KC and The Sunshine Band | Please Don't Go |
| 12 januari | Rupert Holmes | Escape (The Piña Colada Song) |
| 19 januari | Michael Jackson | Rock with You |
| 26 januari | Michael Jackson | Rock with You |
| 2 februari | Michael Jackson | Rock with You |
| 9 februari | Michael Jackson | Rock with You |
| 16 februari | Captain & Tennille | Do That to Me One More Time |
| 23 februari | Queen | Crazy Little Thing Called Love |
| 1 maart | Queen | Crazy Little Thing Called Love |
| 8 maart | Queen | Crazy Little Thing Called Love |
| 15 maart | Queen | Crazy Little Thing Called Love |
| 22 maart | Pink Floyd | Another Brick in the Wall Part 2 |
| 29 maart | Pink Floyd | Another Brick in the Wall Part 2 |
| 5 april | Pink Floyd | Another Brick in the Wall Part 2 |
| 12 april | Pink Floyd | Another Brick in the Wall Part 2 |
| 19 april | Blondie | Call Me |
| 26 april | Blondie | Call Me |
| 3 mei | Blondie | Call Me |
| 10 mei | Blondie | Call Me |
| 17 mei | Blondie | Call Me |
| 24 mei | Blondie | Call Me |
| 31 mei | Lipps Inc. | Funkytown |
| 7 juni | Lipps Inc. | Funkytown |
| 14 juni | Lipps Inc. | Funkytown |
| 21 juni | Lipps Inc. | Funkytown |
| 28 juni | Paul McCartney | Coming Up (Live at Glasgow) |
| 5 juli | Paul McCartney | Coming Up (Live at Glasgow) |
| 12 juli | Paul McCartney | Coming Up (Live at Glasgow) |
| 19 juli | Billy Joel | It's Still Rock And Roll to Me |
| 26 juli | Billy Joel | It's Still Rock And Roll to Me |
| 2 augustus | Olivia Newton-John | Magic |
| 9 augustus | Olivia Newton-John | Magic |
| 16 augustus | Olivia Newton-John | Magic |
| 23 augustus | Olivia Newton-John | Magic |
| 30 augustus | Christopher Cross | Sailing |
| 6 september | Diana Ross | Upside Down |
| 13 september | Diana Ross | Upside Down |
| 20 september | Diana Ross | Upside Down |
| 27 september | Diana Ross | Upside Down |
| 4 oktober | Queen | Another One Bites the Dust |
| 11 oktober | Queen | Another One Bites the Dust |
| 18 oktober | Queen | Another One Bites the Dust |
| 25 oktober | Barbra Streisand | Woman in Love |
| 1 november | Barbra Streisand | Woman in Love |
| 8 november | Barbra Streisand | Woman in Love |
| 15 november | Kenny Rogers | Lady |
| 22 november | Kenny Rogers | Lady |
| 29 november | Kenny Rogers | Lady |
| 6 december | Kenny Rogers | Lady |
| 13 december | Kenny Rogers | Lady |
| 20 december | Kenny Rogers | Lady |
| 27 december | John Lennon | (Just Like) Starting Over |
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* Nederland (Top 40)
* Nederland (Single Top 100)
* Vlaanderen (Radio 2 Top 30)
* Duitsland
* Verenigd Koninkrijk
* Verenigde Staten (Hot 100)