# Leader nei sack in carriera nella National Football League

La seguente è la lista dei giocatori della National Football League che hanno messo a segno almeno 100 sack in carriera nel corso della stagione regolare. La NFL ha iniziato a tenere ufficialmente conto dei sack solamente dalla stagione 1982. I giocatori che hanno messo a segno dei sack prima di quella data non sono inclusi in questa lista.
La lista è aggiornata al termine della stagione 2023 ed i giocatori in grassetto sono ancora in attività.
= Hall of Famer (14 giocatori)
| Pos. | Ruolo | Giocatore | Squadre | Sack | Anno di introduzione nella Pro Football Hall of Fame |
| 1 | DE | Bruce Smith | Buffalo Bills (1985–1999) Washington Redskins (2000–2003) | 200,0 | 2009 |
| 2 | DE | Reggie White | Philadelphia Eagles (1985–1992) Green Bay Packers (1993–1998) Carolina Panthers (2000) | 198,0 | 2006 |
| 3 | LB | Kevin Greene | Los Angeles Rams (1985–1992) Pittsburgh Steelers (1993–1995) Carolina Panthers (1996, 1998–1999) San Francisco 49ers (1997) | 160,0 | 2016 |
| 4 | DE/OLB | Julius Peppers | Carolina Panthers (2002–2009, 2017–2018) Chicago Bears (2010–2013) Green Bay Packers (2014–2016) | 159,5 | — |
| 5 | DE | Chris Doleman | Minnesota Vikings (1985–1993, 1999) Atlanta Falcons (1994–1995) San Francisco 49ers (1996–1998) | 150,5 | 2012 |
| 6 | DE | Michael Strahan | New York Giants (1993–2007) | 141,5 | 2014 |
| 7 | DE | Jason Taylor | Miami Dolphins (1997–2007, 2009, 2011) Washington Redskins (2008) New York Jets (2010) | 139,5 | 2017 |
| 8 | OLB/DE | Terrell Suggs | Baltimore Ravens (2003–2018) Arizona Cardinals (2019) Kansas City Chiefs (2019) | 139,0 | Non eleggibile |
| 9 | OLB/DE | DeMarcus Ware | Dallas Cowboys (2005–2013) Denver Broncos (2014–2016) | 138,5 | 2023 |
| 10 | DT | John Randle | Minnesota Vikings (1990–2000) Seattle Seahawks (2001–2003) | 137,5 | 2010 |
| 10 | DE | Richard Dent | Chicago Bears (1983–1993, 1995) San Francisco 49ers (1994) Indianapolis Colts (1996)  Philadelphia Eagles (1997) | 137,5 | 2011 |
| 12 | DE | Jared Allen | Kansas City Chiefs (2004–2007) Minnesota Vikings (2008–2013) Chicago Bears (2014–2015) Carolina Panthers (2015) | 136,0 | — |
| 13 | DE/OLB | John Abraham | New York Jets (2000–2005) Atlanta Falcons (2006–2012) Arizona Cardinals (2013–2014) | 133,5 | — |
| 14 | DE | Leslie O'Neal | San Diego Chargers (1986–1995) St. Louis Rams (1996–1997) Kansas City Chiefs (1998–1999) | 132,5 | — |
| 14 | LB | Lawrence Taylor | New York Giants (1981–1993) | 132,5 | 1999 |
| 16 | LB | Rickey Jackson | New Orleans Saints (1981–1993) San Francisco 49ers (1994–1995) | 128,0 | 2010 |
| 17 | LB | Derrick Thomas | Kansas City Chiefs (1989–1999) | 126,5 | 2009 |
| 18 | OLB | Dwight Freeney | Indianapolis Colts (2002–2012) San Diego Chargers (2013–2014) Arizona Cardinals (2015) Atlanta Falcons (2016) Seattle Seahawks (2017) Detroit Lions (2017) | 125,5 | — |
| 19 | OLB | Von Miller | Denver Broncos (2011–2019) Los Angeles Rams (2021) Buffalo Bills (2022-presente) | 123,5 | non eleggibile |
| 20 | OLB | Robert Mathis | Indianapolis Colts (2003–2016) | 123,0 | — |
| 21 | DE | Simeon Rice | Arizona Cardinals (1996–2000) Tampa Bay Buccaneers (2001–2006) Denver Broncos (2007) Indianapolis Colts (2007) | 122,0 | — |
| 22 | DE | Clyde Simmons | Philadelphia Eagles (1986–1993) Arizona Cardinals (1994–1995) Jacksonville Jaguars (1996–1997) Cincinnati Bengals (1998) Chicago Bears (1999–2000) | 121,5 | — |
| 23 | DE | Cameron Jordan | New Orleans Saints (2011–presente) | 117,5 | Non eleggibile |
| 24 | DE | J.J. Watt | Houston Texans (2011–2020) Arizona Cardinals (2021–2022) | 114,5 | Non eleggibile |
| 25 | DE | Sean Jones | L.A. Raiders (1984–1987) Houston Oilers (1988–1993) Green Bay Packers (1994–1996) | 113,0 | — |
| 26 | OLB | Justin Houston | Kansas City Chiefs (2011-2018) Indianapolis Colts (2019-2020) Baltimore Ravens (2021-2022) Carolina Panthers (2023-presente) | 112,0 | Non eleggibile |
| 26 | DE | Chandler Jones | New England Patriots (2012-2015) Arizona Cardinals (2016-2021) Las Vegas Raiders (2022) | 112,0 | Non eleggibile |
| 28 | DT | Aaron Donald | Los Angeles Rams (2014-presente) | 111,0 | Non eleggibile |
| 29 | DE | Greg Townsend | L.A. Raiders (1983–1993) Philadelphia Eagles (1994) Oakland Raiders (1997) | 109,5 | — |
| 30 | LB | Pat Swilling | New Orleans Saints (1986–1992) Detroit Lions (1993–1994) Oakland Raiders (1995–1998) | 107,5 | — |
| 31 | DE | Trace Armstrong | Chicago Bears (1989–1994) Miami Dolphins (1995–2000) Oakland Raiders (2001–2003) | 106,5 | — |
| 32 | DE | Calais Campbell | Arizona Cardinals (2008-2016) Jacksonville Jaguars (2017-2019) Baltimore Ravens (2020-2022) Atlanta Falcons (2023-presente) | 105,5 | Non eleggibile |
| 32 | DE | Elvis Dumervil | Denver Broncos (2006–2012) Baltimore Ravens (2013–2016) San Francisco 49ers (2017) | 105,5 | — |
| 34 | DE | Neil Smith | Kansas City Chiefs (1987–1996) Denver Broncos (1997–1999) San Diego Chargers (2000) | 104,5 | — |
| 34 | DE | Kevin Carter | St. Louis Rams (1995–2000) Tennessee Titans (2001–2004) Miami Dolphins (2005–2006) Tampa Bay Buccaneers (2007–2008) | 104,5 | — |
| 36 | DE | Jim Jeffcoat | Dallas Cowboys (1983–1994) Buffalo Bills (1995–1997) | 102,5 | — |
| 37 | DE | Robert Quinn | Los Angeles Rams (2011–2017) Miami Dolphins (2018) Dallas Cowboys (2019) Chicago Bears (2020-2022) Philadelphia Eagles (2022) | 102,0 | Non eleggibile |
| 38 | OLB | Khalil Mack | Oakland Raiders (2014-2017) Chicago Bears (2018-2021) Los Angeles Rams (2022-presente) | 101,5 | Non eleggibile |
| 39 | LB/DE | Charles Haley | San Francisco 49ers (1986–1991, 1998–1999) Dallas Cowboys (1992–1996) | 100,5 | 2015 |
| 39 | DE | William Fuller | Houston Oilers (1986–1993) Philadelphia Eagles (1994–1996) San Diego Chargers (1997–1998) | 100,5 | — |
| 39 | DE/OLB | Cameron Wake | Miami Dolphins (2009–2018) Tennessee Titans (2019) | 100,5 | Non eleggibile |
| 42 | DE | Carlos Dunlap | Cincinnati Bengals (2010-2020) Seattle Seahawks (2020-2021) Kansas City Chiefs (2022) | 100,0 | Non eleggibile |
| 42 | LB | Andre Tippett | New England Patriots (1982–1993) | 100,0 | 2009 |