# Carol Remmer Angle

Carol Remmer Angle es una pediatra, nefróloga, y toxicóloga estadounidense. La Dra. Angle es reconocida como una de las principales investigadoras en saturnismo.

## Biografía

Es profesora emérita del Centro Médico de la Universidad de Nebraska (UNMC) en Omaha, Nebraska. Desarrolla actividades científicas y académicas en la UNMC desde 1971 y fue una de las primeras mujeres en ser presidente de un departamento médico académico (pediatría). Ha sido también Jefa de nefrología pediátrica, directora de la unidad de Cuidados intensivos pediátricos, y director de toxicología médica. En 1957, la Dra. Angle along with Dr. Matilda McIntire, founded one of the country’s first poison control centers. La Dra. Angle es miembro fundadora y presidenta de la American Association of Poison Control Centers. Por cuarenta años, sirvió como experta del NIEHS, National Institutes of Health y de la Agencia de Protección Ambiental de Estados Unidos donde se investiga la toxicidad de metales pesados. Sigue como consultora de toxicología, revisora y editora.

### Formación

Wellesley College; Cornell Medical College School; New York Hospital Pediatric, Internado y Residencia; University of Nebraska Hospital, Residency

## Reconocimiento

* Directora, Educación Médica, Childrens Memorial Hospital, Omaha, Nebraska, 1954-1967
* Directora, Centro de Control de Tóxicos Nebraska Master, 1957-1966
* Coordinadora Estadual, Nebraska Master Poison Control Center, 1957-1966
* Directora, Clínica Pediátrica Renal, Univ. de Nebraska Hospital & Clínicas, 1966-1984
* Directora, Unidad Pediátrica de Cuidados Intensivos, Univ. de Nebraska Hospital, 1968-1974
* Presidenta del Programa, Asociación Americana de Centros de Control Toxicológico, 1977-1979
* Profesora, Dto de Pediatría, Univ. de Nebraska Fac. de Medicina, 1971-1998
* Directora, Fundación Nacional del Centro de Tratamiento de Defectos Congénitos, Children's Memorial Hospital, 1974-1981
* Miembro, Toxicology Advisory Board, U.S. Consumer Product Safety Commission, 1978-1982
* Chairman, Department of Pediatrics, University of Nebraska College of Medicine, 1981-1985
* Miembro, National Advisory Environmental Health Sciences Council, NIH, 1984-1987
* Directora, Clinical Toxicology, University of Nebraska Medical Center, 1985-1998
* Editora jefa, Journal of Toxicology - Clinical Toxicology, 1989-2002
* Profesora emérita, Dto. de Pediatría, University of Nebraska College of Medicine, 1999–present
* Honor Award, Matthew J. Ellenhorn Award, 2003
* Galardón de Honor, University of Nebraska Medical Center Legends Award, 2008 Archivado el 4 de marzo de 2016 en Wayback Machine.

## Publicaciones

* Angle CR: Congenital bowing and angulation of long bones. Pediatrics 13:257-267, 1954
* Angle CR: Poison control outlines: toxicity of insecticides and herbicides. Nebr Med J 48:644-646, 1963
* Angle CR and McIntire MS: Lead poisoning during pregnancy: fetal tolerance of calcium disodium edentate. Am J Dis Child 108:436-439, 1964
* Angle CR: Acute renal failure. J Lancet 86:355-362, 1966
* Angle CR and McIntire MS: Evaluation of a poison information center. J Lancet 86:363-365, 1966
* Angle CR, McIntire MS and Moore, RC: Cloverleaf skull: Kleeblattschadel-deformity syndrome. Am J Dis Child 114:098-202, 1967
* Angle CR, McIntire MS and Zetterman RA: CNS symptoms in childhood poisoning. Clin Toxicol 1:19-29, 1968
* Angle CR, McIntire MS and Meile R: Neurologic sequelae of poisoning in children. J Pediat 73:531-539, 1968
* Angle CR and McIntire MS: Persistent dystonia in a brain damaged child after ingestion of phenothiazine. J Pediat 73:124-126, 1968
* Angle CR and Glyn M: The value of a pediatric high intensity care unit. Nebr Med J 54:737-740, 1969
* Angle CR: Symposium on iron poisoning. Clin Tox 4:525-527, 1971
* Angle CR and McIntire MS: Red cell lead, whole blood lead and red cell enzymes. Environ Health Perspect 7:133-137, 1974
* Angle CR and Wermers J: Human poisoning with flea-dip concentrate. J Am Vet Med Assc 165:174-175, 1974
* Angle CR, McIntire MS and Vest BS: Blood lead of Omaha school children topographic correlation with industry, traffic and housing. Nebr Med J 60:97-102, 1975
* Angle CR: Locomotor skills and school accidents. Pediatrics 56:819-822, 1975
* Angle CR, McIntire MS and Brunk G: Effect of anemia on blood and tissue lead in rats. J Toxicol Environ Health 3:557-563, 1977
* Angle CR, Trembath EJ and Strond W: The myelodysplasia and hydrocephalus program in Nebraska: A 15 year review of cost and benefits, Park I. Nebr Med J 62:359-361 (Oct), 1977; Part II. Nebr Med J 63:391-939 (nov) 1977
* Angle CR and McIntire MS: Lead, mercury and cadmium: toxicity in children. Paediatrician 6:204-225, 1977
* Angle CR and McIntire MS: Low level lead and inhibition of erythrocyte pyrimidine nucleotidase. Environ Res 17:296-302, 1978
* Angle CR and McIntire MS: Environmental lead and children – the Omaha Study. J Toxicol Environ Health 5:855-870, 1979
* Angle CR, Stohs SJ, McIntire MS, Swanson MS and Rovang K: Lead induced accumulation of erythrocyte pyrimidine nucleotides in the rabbit. Toxicol Appl Pharmacol 54:161-167, 1980
* Angle CR: The Department of Pediatrics, UNMC. Neb Med J 53-54, 1981
* Angle CR, McIntire MS, Swanson MS and Stohs SJ: Erythrocyte nucleotides in children – increased blood lead and cytidine triphosphate. Pediatr Res 16:331-334, 1982
* Angle CR, O’Brien TP and McIntire MS: Adolescent self-poisoning – a 9 year follow-up. JDBP 4:83-87, 1983
* Angle CR, Marcus A, Cheng I and McIntire MS: Omaha childhood blood lead and environmental lead: A linear exposure model. Environ Res 35:160-170, 1984
* Angle CR, Swanson MS, Stohs SJ and Markin RS: Abnormal erythrocyte pyrimidine nucleotides in uremic subjects. Nephron 39:169-174, 1985
* Angle CR and Kuntzelman DR: Increased erythrocyte protoporphyrins and blood lead – A pilot study of childhood growth patterns. J Toxicol Environ Health 26:149-156, 1989
* Angle CR, Thomas DJ and Swanson SA: Toxicity of cadmium to rat osteosarcoma cells (ROS 17/2.8): Protective effect of 1,25 dihydroxy vitamin D3. Toxicol Appl Pharmacol 103:113-120, 1990
* Angle CR, Thomas DJ and Swanson SA: Lead inhibits the basal and stimulated responses of a rat osteoblast-like cell line ROS 17/2.8 to 1,25 dihydroxyvitamine D3 and IGF-I. Toxicol Appl Pharmacol 103:281-287, 1990
* Angle CR, Thomas DJ, Swanson SA: Osteotoxicity of cadmium and lead in HOS TE 85 and ROS 17/2.8 cells: Relation to metallothionein induction and mitochondrial binding. BioMetals 5:179-184, 1993
* Angle CR, Manton WI, Stanek KL. Stable isotope Identification of Lead Sources in Preschool Children-the Omaha Study. J Toxicol Clin Toxicol 33:657-62, 1995
* Angle CR, Swanson SA: Arsenite enhances homocysteine-induced proliferation of fibroblasts in human aortic smooth muscle cells in B12 (Cobalamin) deficient media. Submitted to Environmental Health Perspectives, julio de 1997
* Angle CR. Pitfalls of correlation of childhood blood lead and cognitive development. J Toxicol Clin Toxicol 40(4):521-2, 2002