# WikiJournal Preprints/Potential Of Cassava Leaf Extract (Manihot esculenta Crantz.) In Reducing Of Chronic Inflammatory Cells In Rats Liver Peridontitis Model

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This article has been withdrawn by the submitting author for publication by the WikiJournal of Medicine.
It is archived below as a record. Discussion can be viewed here.
First submitted: 15 Dec 2022 Withdrawn: 4 May 2023 Reviewer comments
QID: Q116737986
Suggested (provisional) preprint citation format: anon until publication decision. "Potential Of Cassava Leaf Extract (Manihot esculenta Crantz.) In Reducing Of Chronic Inflammatory Cells In Rats Liver Peridontitis Model". WikiJournal Preprints. Wikidata Q116737986.
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This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction, provided the original author and source are credited.

## Article information

Author: anon until publication decision

## Abstract

with a high prevalence in Indonesia caused by Porphyromonas gingivalis. P.gingivalis is a periodontal pathogen often associated with systemic disorders. P. gingivalis and its products carried by the systemic circulation to reach the liver will trigger the inflammatory process and cause inflammatory cell infiltration. Continuous inflammation can eventually lead to chronic liver injury. Periodontitis treatment can be done by giving metronidazole. However, it comes with side effects. One alternative natural plant that provides antibacterial and anti-inflammatory effects is cassava leaves. Objective: To determine the potential of cassava leaf extract (Manihot esculenta Crantz.) in reducing the number of chronic inflammatory cells in the liver of periodontitis rat models. Research methods: This research is an experimental laboratory with a posttest-only control group design. The research sample was male Wistar rats divided into four groups: baseline, periodontitis group which was given aquadest, metronidazole, and cassava leaf extract. A rat model of P. gingivalis was induced with periodontitis. The rats were then euthanized, their livers were taken, and histological preparations were made with HE staining. Observation and counting of chronic inflammatory cells were performed around the central vein. The one-way ANOVA test was carried out based on the data from the research. Results: The results of the LSD test with a significance value of p<0.05 showed a significant difference between the baseline group and the treatment group. There was no significant difference between the extract group and the positive control group and between the extract group and the negative control group.

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