OpenLLM-France/wikimedia huggingface dataset:
# EuroLex/F/Coupe

* Original language: French
* Original form and meaning: coupe - 1. beaker, tumbler, goblet; 2. cup; 3. bowl; 4. [textil.] cut; 5. [ling.] break
(Note: If the status is not specifically indicated then the word is stylistically neutral and generally used; if earlier meaning and status equals current use the former may be expressed by writing "dito". Cf. also the project guidelines.)
| Language | Form | Date of Borrowing (and Obsolescence) | Current Meaning and Status | Earlier Meanings and Statusses | Source |
| Catalan | ... | ... | '...' | '...' | ... |
| Croatian | ... | ... | '...' | '...' | ... |
| Czech | ... | ... | '...' | '...' | ... |
| Danish | ... | ... | '...' | '...' | ... |
| Dutch | ... | ... | '...' | '...' | ... |
| English | coupe | wicker basket: 1375–1425; current senses: 1890–95 | 'meaning 3, especially for a dessert of ice cream or fruit-flavoured ice; and also: a) ice cream or sherbet mixed or topped with fruit, liqueur, whipped cream, etc. b) any rimless plate c) variant of coupé (car)' | 'wicker basket, tub, cask' | http://dictionary.reference.com/ |
| Estonian | ... | ... | '...' | '...' | ... |
| Finnish | ... | ... | '...' | '...' | ... |
| French | ... | ... | '...' | '...' | ... |
| Frisian | ... | ... | '...' | '...' | ... |
| German | Coupe | ... | 'meaning 2; and also: sundae' | '...' | ... |
| Hungarian | ... | ... | '...' | '...' | ... |
| Irish | ... | ... | '...' | '...' | ... |
| Italian | coppa | ... | 'meaning 3, especially for ice cream' | '...' | ... |
| Latvian | ... | ... | '...' | '...' | ... |
| Lithuanian | ... | ... | '...' | '...' | ... |
| Maltese | ... | ... | '...' | '...' | ... |
| Norwegian | ... | ... | '...' | '...' | ... |
| Polish | ... | ... | '...' | '...' | ... |
| Portuguese | cupê | ... | 'meaning 3, especially for ice cream' | '...' | ... |
| Rumantsch | ... | ... | '...' | '...' | ... |
| Slovak | ... | ... | '...' | '...' | ... |
| Slovenian | ... | ... | '...' | '...' | ... |
| Spanish | copa | ... | 'meaning 3, especially for ice cream' | '...' | ... |
| Swedish | glasscoupe | ... | 'meaning 3, especially for ice cream' | '...' | ... |

### Annotations

Etymology: ME < AF co(u)pe, OF coupe < LL cuppa, L cūpa "cask, tub, barrel"
Source: http://dictionary.reference.com/

### Information on Other Languages

Danish: portionsglas
Dutch: sorbet(glas)
# EuroLex/F/Coupon

* Original language: French
* Original form and meaning: coupon - 1. coupon, voucher; 2. [finan.] bond coupon, interest coupon, interest voucher, interest warrant
(Note: If the status is not specifically indicated then the word is stylistically neutral and generally used; if earlier meaning and status equals current use the former may be expressed by writing "dito". Cf. also the project guidelines.)
| Language | Form | Date of Borrowing (and Obsolescence) | Current Meaning and Status | Earlier Meanings and Statusses | Source |
| Catalan | ... | ... | '...' | '...' | ... |
| Croatian | ... | ... | '...' | '...' | ... |
| Czech | kupon | ... | 'meaning 1, 2' | '...' | ... |
| Danish | kupon | ... | 'meaning 1, 2' | '...' | ... |
| Dutch | coupon | ... | 'meaning 1, 2' | '...' | ... |
| English | coupon | certificate of interest due on a bond: 1822 discount ticket: 1860s specific advertising sense: 1906 | 'meaning 1, 2; and also: Metallurgy: a sample of metal or metalwork submitted to a customer or testing agency for approval' | '...' | http://www.etymonline.com |
| Estonian | ... | ... | '...' | '...' | ... |
| Finnish | kuponki | ... | 'meaning 1, 2' | '...' | ... |
| French | ... | ... | '...' | '...' | ... |
| Frisian | ... | ... | '...' | '...' | ... |
| German | Coupon | 1776 | 'meaning 1, 2' | '...' | http://www.koeblergerhard.de/derwbhin.html |
| Hungarian | kupon | ... | 'meaning 1, 2' | '...' | ... |
| Irish | ... | ... | '...' | '...' | ... |
| Italian | ... | ... | '...' | '...' | ... |
| Latvian | kupons | ... | 'meaning 1, 2' | '...' | ... |
| Lithuanian | kuponas | ... | 'meaning 1, 2' | '...' | ... |
| Maltese | ... | ... | '...' | '...' | ... |
| Norwegian | rabattkupong | ... | 'meaning 1' | '...' | ... |
| Polish | ... | ... | '...' | '...' | ... |
| Portuguese | cupão, cupom | ... | 'meaning 1, 2' | '...' | ... |
| Rumantsch | ... | ... | '...' | '...' | ... |
| Slovak | kupón | ... | 'meaning 1, 2' | '...' | ... |
| Slovenian | ... | ... | '...' | '...' | ... |
| Spanish | cupón | ... | 'meaning 1, 2' | '...' | ... |
| Swedish | kupong | ... | 'meaning 1, 2' | '...' | ... |

### Annotations

Etymology: from F coupon, from OF coupon "piece cut off", from couper "to cut", from coup "a blow".
Meaning widened to "discount ticket" 1860s by British travel agent Thomas Cook. The specific advertising sense is from 1906.
Source: http://www.etymonline.com

### Information on Other Languages

Estonian: lõigend Italian: cedola, buono Polish: talon Slovenian: odrezek
# EuroLex/F/Coiffeur

* Original language: French
* Original form and meaning: coiffeur - 1. hairdesser, barber
(Note: If the status is not specifically indicated then the word is stylistically neutral and generally used; if earlier meaning and status equals current use the former may be expressed by writing "dito". Cf. also the project guidelines.)
| Language | Form | Date of Borrowing (and Obsolescence) | Current Meaning and Status | Earlier Meanings and Statusses | Source |
| Catalan | ... | ... | '...' | '...' | ... |
| Croatian | ... | ... | '...' | '...' | ... |
| Czech | ... | ... | '...' | '...' | ... |
| Danish | ... | ... | '...' | '...' | ... |
| Dutch | ... | ... | '...' | '...' | ... |
| English | male: coiffeur, female: coiffeuse | 1847 | 'meaning 1' | '...' | http://www.etymonline.com/ |
| Estonian | ... | ... | '...' | '...' | ... |
| Finnish | ... | ... | '...' | '...' | ... |
| French | ... | ... | '...' | '...' | ... |
| Frisian | ... | ... | '...' | '...' | ... |
| German | male: Coiffeur, female: Coiffeuse | ... | 'meaning 1, higher register' | '...' | ... |
| Hungarian | ... | ... | '...' | '...' | ... |
| Irish | ... | ... | '...' | '...' | ... |
| Italian | ... | ... | '...' | '...' | ... |
| Latvian | ... | ... | '...' | '...' | ... |
| Lithuanian | ... | ... | '...' | '...' | ... |
| Maltese | ... | ... | '...' | '...' | ... |
| Norwegian | ... | ... | '...' | '...' | ... |
| Polish | ... | ... | '...' | '...' | ... |
| Portuguese | ... | ... | '...' | '...' | ... |
| Rumantsch | Coiffeur | ... | 'meaning 1' | '...' | ... |
| Slovak | ... | ... | '...' | '...' | ... |
| Slovenian | ... | ... | '...' | '...' | ... |
| Spanish | ... | ... | '...' | '...' | ... |
| Swedish | ... | ... | '...' | '...' | ... |

### Annotations

Etymology: word for "hairdresser", from coiffer "to dress hair", from OF coife, originally "inner part of the helmet". A female hairdresser would properly be a coiffeuse.
Sorce: http://www.etymonline.com

### Information on Other Languages

The more common German word for Coiffeur is Friseur/Frisör, which also derived from F. The root is the F verb friser (to curl, to frizz). The (politically correct) female form is Friseurin/Frisörin.
Source: http://de.wikipedia.org/wiki/Friseur
# Gene transcriptions/Boxes/Quiz

Boxes is a lecture as part of the gene transcription series.
You are free to take this quiz based on the boxes at any time.
To improve your score, read and study the lecture, the links contained within, listed under See also, External links, and in the {{gene project}} template. This should give you adequate background to get 100 %.
As a "learning by doing" resource, this quiz helps you to assess your knowledge and understanding of the information, and it is a quiz you may take over and over as a learning resource to improve your knowledge, understanding, test-taking skills, and your score.
Suggestion: Have the lecture available in a separate window.
To master the information and use only your memory while taking the quiz, try rewriting the information from more familiar points of view, or be creative with association.
Enjoy learning by doing!

## Hypotheses

* A1BG is not transcribed by a box.
# Gene transcriptions/Boxes/TACTAACs

"A consensus sequence TACTAA(C/T) was derived for the branch site of Dictyostelium introns."

## Consensus sequences

"The comparison of the two rp51 genes [...] suggests that this homology might be more extensive if one allows up to 3 bases to differ from a larger consensus sequence, ATTTACTAAC."

## Samplings of the A1BG promoters

For the Basic programs (starting with SuccessablesTACT.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:
* negative strand in the negative direction (from ZSCAN22 to A1BG) is SuccessablesTACT--.bas, looking for 3'-TACTAA(C/T)-5', 0,
* negative strand in the positive direction (from ZNF497 to A1BG) is SuccessablesTACT-+.bas, looking for 3'-TACTAA(C/T)-5', 0,
* positive strand in the negative direction is SuccessablesTACT+-.bas, looking for 3'-TACTAA(C/T)-5', 0,
* positive strand in the positive direction is SuccessablesTACT++.bas, looking for 3'-TACTAA(C/T)-5', 1, 3'-TACTAAT-5', 718,
* complement, negative strand, negative direction is SuccessablesTACTc--.bas, looking for 3'-ATGATT(A/G)-5', 0,
* complement, negative strand, positive direction is SuccessablesTACTc-+.bas, looking for 3'-ATGATT(A/G)-5', 1, 3'-ATGATTA-5', 718,
* complement, positive strand, negative direction is SuccessablesTACTc+-.bas, looking for 3'-ATGATT(A/G)-5', 0,
* complement, positive strand, positive direction is SuccessablesTACTc++.bas, looking for 3'-ATGATT(A/G)-5', 0,
* inverse complement, negative strand, negative direction is SuccessablesTACTci--.bas, looking for 3'-(A/G)TTAGTA-5', 0,
* inverse complement, negative strand, positive direction is SuccessablesTACTci-+.bas, looking for 3'-(A/G)TTAGTA-5', 0,
* inverse complement, positive strand, negative direction is SuccessablesTACTci+-.bas, looking for 3'-(A/G)TTAGTA-5', 0,
* inverse complement, positive strand, positive direction is SuccessablesTACTci++.bas, looking for 3'-(A/G)TTAGTA-5', 1, 3'-ATTAGTA-5', 709,
* inverse, negative strand, negative direction, is SuccessablesTACTi--.bas, looking for 3'-(C/T)AATCAT-5', 0,
* inverse, negative strand, positive direction, is SuccessablesTACTi-+.bas, looking for 3'-(C/T)AATCAT-5', 1, 3'-TAATCAT-5', 709,
* inverse, positive strand, negative direction, is SuccessablesTACTi+-.bas, looking for 3'-(C/T)AATCAT-5', 0,
* inverse, positive strand, positive direction, is SuccessablesTACTi++.bas, looking for 3'-(C/T)AATCAT-5', 0.
# Gene transcriptions/Boxes/Ms/Quiz

M boxes is a lecture of the gene transcription series.
You are free to take this quiz based on the M boxes at any time.
To improve your score, read and study the lecture, the links contained within, listed under See also, External links, and in the {{gene project}} template. This should give you adequate background to get 100 %.
As a "learning by doing" resource, this quiz helps you to assess your knowledge and understanding of the information, and it is a quiz you may take over and over as a learning resource to improve your knowledge, understanding, test-taking skills, and your score.
Suggestion: Have the lecture available in a separate window.
To master the information and use only your memory while taking the quiz, try rewriting the information from more familiar points of view, or be creative with association.
Enjoy learning by doing!

## Hypotheses

* A1BG is not transcribed using a T box.
# Gene transcriptions/Boxes/Ps
## Pyrimidine boxes

"Functional analyses of a number of hydrolase gene promoters, induced by gibberellin (GA) in aleurone cells following germination, have identified a GA-responsive complex as a tripartite element containing a pyrimidine box motif 5′-CCTTTT-3′."
"Although this GARC [GA responsive complex] may not always be tripartite, most often it includes three sequence motifs, the TAACAAA box or GA responsive element (GARE), the pyrimidine box CCTTTT, and the TATCCAC box (Skriver et al., 1991;Gubler and Jacobsen, 1992; Rogers et al., 1994)."
The "complementary strand of the pyrimidine box element (5′-CTTTT-3′) in GA-induced hydrolase gene promoters was identical to the core sequence (5′-AAAAG-3′) recognized by PBF in prolamin gene promoters (P-box: 5′-T/AAAAG-3′; Vicente-Carbajosa et al., 1997; Mena et al., 1998; Yanagisawa and Schmidt, 1999)".

## Prolamin boxes

"The BPBF [barley prolamin-box (P-box) binding factor] expressed in bacteria as a GST-fusion binds a P-box 5′-TGTAAAG-3′ containing oligonucleotide derived from the promoter region of anHor2gene."
"The primary structure of hordein [barley prolamins] polypeptides is closely related to that of prolamins from other grass species from the Pooideae subfamily, such as wheat and rye (Shewry & Tatham 1990;Shewry et al. 1995). The close evolutionary relationship is also manifested by the conservation of a putative regulatory element in their gene promoters, the endosperm box (Forde et al. 1985;Kreis et al. 1985). This conserved region consists of two motifs, a 7 bp element (5′TGTAAAG3′) termed the Prolamin Box (P-box) or endosperm motif (EM) followed at a distance of up to 8 nucleotides by the GCN4-like motif (GLM) which has the 5′(G/A)TGA(G/C)TCA(T/C)3′ consensus sequence (reviewed by Müller et al. 1995)."

## V and P boxes

"As VRI [target gene: vrille (VRI)] accumulates in the nucleus during the mid to late day, it binds VRI/PDP1ϵ binding sites (V/P-boxes) [consensus A(/G)TTA(/T)T(/C):GTAAT(/C)], to repress Clk and cry transcription (Hardin, 2004)."
"REV-ERBα and RORa are nuclear receptors rather than bZIP transcription factors like VRI and PDP1ϵ, and they regulate transcription by binding RORE elements rather than V/P-boxes (Bell-Pedersen et al., 2005)."

## Consensus sequences

P box consensus sequence is 3'-GTAA(T/C)-5'.
# Gene transcriptions/Boxes/Pribnow

"Although the first five bases of the conserved sequence are identical to the first five bases of the Pribnow box (TATAA), the sixth base of the Pribnow box is a 100 per cent conserved T (refs 15-17) while the 100 per cent conserved A found here is actually more similar to eukaryotic promoter sequences$^{20}$."
"Two domains upstream of the start site of transcription have been identified for which a consensus sequence has been formulated(1-5). These domains are the -35 sequence (5'-T-T-G-A-C-A) and the Pribnow box (5'-T-A-T-A-A-T) in the -10 region. Both domains are in close contact with the RNA polymerase during initiation of RNAsynthesis (2,6)."

## Samplings

For the Basic programs (starting with SuccessablesPrib.bas) written to compare nucleotide sequences with the sequences on either the template strand (-), or coding strand (+), of the DNA, in the negative direction (-), or the positive direction (+), the programs are, are looking for, and found:
* negative strand in the negative direction (from ZSCAN22 to A1BG) is SuccessablesPrib--.bas, looking for 3'-TATAAT-5', 2, 3'-TATAAT-5', 3454, 3'-TATAAT-5', 3468,
* negative strand in the positive direction (from ZNF497 to A1BG) is SuccessablesPrib-+.bas, looking for 3'-TATAAT-5', 1, 3'-TATAAT-5', 729,
* positive strand in the negative direction is SuccessablesPrib+-.bas, looking for 3'-TATAAT-5', 0,
* positive strand in the positive direction is SuccessablesPrib++.bas, looking for 3'-TATAAT-5', 0,
* complement, negative strand, negative direction is SuccessablesPribc--.bas, looking for 3'-ATATTA-5', 0,
* complement, negative strand, positive direction is SuccessablesPribc-+.bas, looking for 3'-ATATTA-5', 0,
* complement, positive strand, negative direction is SuccessablesPribc+-.bas, looking for 3'-ATATTA-5', 2, 3'-ATATTA-5', 3454, 3'-ATATTA-5', 3468,
* complement, positive strand, positive direction is SuccessablesPribc++.bas, looking for 3'-ATATTA-5', 1, 3'-ATATTA-5', 729,
* inverse complement, negative strand, negative direction is SuccessablesPribci--.bas, looking for 3'-ATTATA-5', 2, 3'-ATTATA-5', 272, 3'-ATTATA-5', 603,
* inverse complement, negative strand, positive direction is SuccessablesPribci-+.bas, looking for 3'-ATTATA-5', 1, 3'-ATTATA-5', 727,
* inverse complement, positive strand, negative direction is SuccessablesPribci+-.bas, looking for 3'-ATTATA-5', 0,
* inverse complement, positive strand, positive direction is SuccessablesPribci++.bas, looking for 3'-ATTATA-5', 0,
* inverse, negative strand, negative direction, is SuccessablesPribi--.bas, looking for 3'-TAATAT-5', 0,
* inverse, negative strand, positive direction, is SuccessablesPribi-+.bas, looking for 3'-TAATAT-5', 0,
* inverse, positive strand, negative direction, is SuccessablesPribi+-.bas, looking for 3'-TAATAT-5', 2, 3'-TAATAT-5', 272, 3'-TAATAT-5', 603,
* inverse, positive strand, positive direction, is SuccessablesPribi++.bas, looking for 3'-TAATAT-5', 1, 3'-TAATAT-5', 727.
# Gene transcriptions/Boxes/TACTAACs/Quiz

TACTAAC box is a lecture of the gene transcription series.
You are free to take this quiz based on the TACTAAC box at any time.
To improve your score, read and study the lecture, the links contained within, listed under See also, External links, and in the {{gene project}} template.
This should give you adequate background to get 100 %.
As a "learning by doing" resource, this quiz helps you to assess your knowledge and understanding of the information, and it is a quiz you may take over and over as a learning resource to improve your knowledge, understanding, test-taking skills, and your score.
Suggestion: Have the lecture available in a separate window.
To master the information and use only your memory while taking the quiz, try rewriting the information from more familiar points of view, or be creative with association.
Enjoy learning by doing!

## Hypotheses

* A TACTAAC box is not used to transcribe A1BG.
# Gene transcriptions/Boxes/Ms

"In melanocytes and in melanoma cells, cyclic AMP (cAMP)-elevating agents stimulate melanogenesis and increase the transcription of tyrosinase, the rate-limiting enzyme in melanin synthesis. However, two other enzymes, tyrosinase-related protein 1 (TRP1) and TRP2, are required for a normal melanization process leading to eumelanin synthesis. In B16 melanoma cells, we demonstrated that stimulation of melanogenesis by cAMP-elevating agents results in an increase in tyrosinase, TRP1, and TRP2 expression. cAMP, through a cAMP-dependent protein kinase pathway, stimulates TRP1 and TRP2 promoter activities in both B16 mouse melanoma cells and normal human melanocytes. Regulation of the TRP1 and TRP2 promoters by cAMP involves a M box and an E box."
"[M]icrophthalmia, a basic helix-loop-helix transcription factor, strongly stimulates the transcriptional activities of the TRP1 and TRP2 promoters, mainly through binding to the M boxes."
"In mammals, pigmentation results from the synthesis and distribution of melanin in the skin, hair bulbs, and eyes. Melanin synthesis (melanogenesis) takes place in the melanocyte after differentiation of the nonpigmented precursor, the melanoblast (27). Three melanocyte-specific enzymes, tyrosinase, tyrosinase-related protein 1 (TRP1), and TRP2, are involved in this enzymatic process that converts tyrosine to melanin pigments. Although these proteins have similar structures and features, they are expressed by different genes and possess distinct enzymatic activities. Tyrosinase, encoded by the albino locus of the mouse, catalyzes the conversion of tyrosine to 3,4-dihydroxyphenylalanine (DOPA) and of DOPA to DOPA quinone (14, 25, 31). TRP2, encoded by the mouse slaty locus, possesses a Dopachrome tautomerase activity, converting the Dopachrome to 5,6-dihydroxyindole-2-carboxylic acid (DHICA) (3, 19, 42). TRP1, which has been mapped in mouse to the brown locus, catalyzes the oxidation of DHICA to indole-5,6-quinone-2-carboxylic acid (21, 24)."
"In the TRP1 promoter, the M box (GTCATGTGCT) [is] located between bp −44 and −33 upstream from the initiation start site [...] and the E box (CAAGTG) [is] located between bp −238 and −233 [...] In the TRP2 promoter, the M box (GTCATGTGCT) [is] located between bp −135 and −129 upstream from the initiation start site [...] the E box (CACATG) [is] between bp −346 and −340 [and] the cAMP response element (CRE; TGAGGTCA) [is] located between bp −239 and −232 [...]."
The "regulation of TRP1 gene expression by PKA in B16 melanoma cells involves the M box just upstream of the TATA box."

## Consensus sequences

"Tyrosinase and TRP1 promoters share an 11-bp motif (AGTCATGTGCT) termed the M box located upstream of the TATA box. This motif binds microphthalmia, a basic helix-loop-helix transcription factor that increases tyrosinase and TRP1 promoter activities, thereby playing a key role in the tissue-specific expression of these genes (11, 29, 40). In the TRP2 promoter, a homologous sequence (GTCATGTGCT) is also found upstream of the TATA box (41)."
# MDLD/nested intervals

Start=nested intervals Target=Real numbers/Nested intervals/Definition
# MDLD/odd function (R)

Start=odd function (R) Target=R to R/Odd function/Definition
# MDLD/odd functions (R)

Start=odd functions (R) See=odd function (R) MDLD/odd function (R) Target=R to R/Odd function/Definition
# MDLD/ordered field

Start=ordered field Target=Ordered_field/Detailed/Definition
# MDLD/polynomial (1)

Start=polynomial (1) Target=Polynomial/Field/1/Definition
# MDLD/polynomial (1K)

Start=polynomial (1K) Target=Polynomial/Field/1/Definition
# MDLD/polynomial function (R)

Start=polynomial function (R) Target=Polynomial/Field/1/Definition
# MDLD/odd (real function)

Start=odd (real function) Target=R to R/Odd function/Definition
# MDLD/open interval (R)

Start=open interval (R) Target=Real numbers/Intervals/Definition
# MDLD/polynomial (1R)

Start=polynomial (1R) Target=Polynomial/Field/1/Definition
# Lymphoid organs

Organs associated with immune system are lymphoid organs.
There are two types of lymphoid organs:-
* Primary lymphoid organs
* Secondary lymphoid organs

### Primary lymphoid organs (central lymphoid system)

Primary lymphoid organs are site of hemopoiesis. They produce progenitor cells which are non functional till they get a antegenic stimulus.Lymphocytes produced here moves to secondary lymphoid organs where they get antigenic stimulus and the cells become functional.the primary lymphoid organs are:-
* THYMUS
* Bursa of fabricius (only in birds)
* BONE MARROW
It is the organ present above 1st sternae and below thyroid. This organ produces T lymphocytes. It brings about cell mediated immunity, graft rejection.
   Bone marrow
Flexible tissue in the bone interior.This organ acts both as primary and secondary lymphoid organs.this is the site of production of B lymphocytes.

### Secondary lymphoid organs (peripheral lymphoid system)

Maintenance of naive and mature lymphocytes takes place here.Initiation of adaptive immune response and activation of lymphocyte by antigen occurs .the three secondary lymphoid organs are as follows:-
* LYMPH NODE
* SPLEEN
* MALT (Mucosa associated lymphoid tissue)

### lymph node

It is small bean shaped structure which carries lymph fluid, nutrients and waste materials between body tissues and blood stream.

### Spleen

It is the organ present in the abdominal cavity.Filtering of blood takes place here.Old RBCs gets regenerated here.WBCs ,RBCs and platelets gets stored here.

### MALT

It is the diffuse system of small concentrations of lymphoid tissue found in various submucosal membrane sites of body such as gastro intestinal tract, thyroid, breast, salivary gland, eye and skin.
Tonsils and payer's patch of small intestine are the major tissues belonging to MALT .