# Endocrine, nutritional and metabolic diseases (E00-E90)Endocrine, nutritional and metabolic diseases (E00-E90)

    All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
    Excludes1: transitory endocrine and metabolic disorders specific to newborn (P70-P74)
    This chapter contains the following blocks:
    E00-E07 Disorders of thyroid gland
    E08-E13 Diabetes mellitus
    E15-E16 Other disorders of glucose regulation and pancreatic internal secretion
    E20-E35 Disorders of other endocrine glands
    E36 Intraoperative complications of endocrine system
    E40-E46 Malnutrition
    E50-E64 Other nutritional deficiencies
    E65-E68 Overweight, obesity and other hyperalimentation
    E70-E88 Metabolic disorders
    E89 Postprocedural endocrine and metabolic complications and disorders, not elsewhere classified

# Disorders of thyroid gland (E00-E07)Disorders of thyroid gland (E00-E07)
## E00 Congenital iodine-deficiency syndromeE00 Congenital iodine-deficiency syndrome

    Use additional code (F70-F79) to identify associated mental retardation.
    Excludes1: subclinical iodine-deficiency hypothyroidism (E02)
    E00.0 Congenital iodine-deficiency syndrome, neurological type
       Endemic cretinism, neurological type
    E00.1 Congenital iodine-deficiency syndrome, myxedematous type
       Endemic hypothyroid cretinism
       Endemic cretinism, myxedematous type
    E00.2 Congenital iodine-deficiency syndrome, mixed type
       Endemic cretinism, mixed type
    E00.9 Congenital iodine-deficiency syndrome, unspecified
       Congenital iodine-deficiency hypothyroidism NOS
       Endemic cretinism NOS

## E01 Iodine-deficiency related thyroid disorders and allied conditionsE01 Iodine-deficiency related thyroid disorders and allied conditions

    Excludes1: congenital iodine-deficiency syndrome (E00.-)
       subclinical iodine-deficiency hypothyroidism (E02)
    E01.0 Iodine-deficiency related diffuse (endemic) goiter
    E01.1 Iodine-deficiency related multinodular (endemic) goiter
       Iodine-deficiency related nodular goiter
    E01.2 Iodine-deficiency related (endemic) goiter, unspecified
       Endemic goiter NOS
    E01.8 Other iodine-deficiency related thyroid disorders and allied conditions
       Acquired iodine-deficiency hypothyroidism NOS

## E03 Other hypothyroidismE03 Other hypothyroidism

    Excludes1: iodine-deficiency related hypothyroidism (E00-E02)
       postprocedural hypothyroidism (E89.0)
    E03.0 Congenital hypothyroidism with diffuse goiter
       Congenital parenchymatous goiter (nontoxic)
       Congenital goiter (nontoxic) NOS
       Excludes1: transitory congenital goiter with normal function (P72.0)
    E03.1 Congenital hypothyroidism without goiter
       Aplasia of thyroid (with myxedema)
       Congenital atrophy of thyroid
       Congenital hypothyroidism NOS
    E03.2 Hypothyroidism due to medicaments and other exogenous substances
       Code first (T36-T65) to identify drug or substance
    E03.3 Postinfectious hypothyroidism
    E03.4 Atrophy of thyroid (acquired)
       Excludes1: congenital atrophy of thyroid (E03.1)
    E03.5 Myxedema coma
    E03.8 Other specified hypothyroidism
    E03.9 Hypothyroidism, unspecified
       Myxedema NOS

## E04 Other nontoxic goiterE04 Other nontoxic goiter

    Excludes1: congenital goiter (NOS) (diffuse) (parenchymatous) (E03.0)
       iodine-deficiency related goiter (E00-E02)
    E04.0 Nontoxic diffuse goiter
       Diffuse ( ​colloid) nontoxic goiter
       Simple nontoxic goiter
    E04.1 Nontoxic single thyroid nodule
       Colloid nodule (cystic) (thyroid)
       Nontoxic uninodular goiter
       Thyroid (cystic) nodule NOS
    E04.2 Nontoxic multinodular goiter
       Cystic goiter NOS
       Multinodular (cystic) goiter NOS
    E04.8 Other specified nontoxic goiter
    E04.9 Nontoxic goiter, unspecified
       Goiter NOS
       Nodular goiter (nontoxic) NOS

## E05 Thyrotoxicosis [hyperthyroidism]E05 Thyrotoxicosis [hyperthyroidism]

    Excludes1: chronic thyroiditis with transient thyrotoxicosis (E06.2)
       neonatal thyrotoxicosis (P72.1)
    E05.0 Thyrotoxicosis with diffuse goiter
       Exophthalmic or toxic goiter NOS
       Graves' disease
       Toxic diffuse goiter
       E05.00 Thyrotoxicosis with diffuse goiter without thyrotoxic crisis or storm
       E05.01 Thyrotoxicosis with diffuse goiter with thyrotoxic crisis or storm
    E05.1 Thyrotoxicosis with toxic single thyroid nodule
       Thyrotoxicosis with toxic uninodular goiter
       E05.10 Thyrotoxicosis with toxic single thyroid nodule without thyrotoxic crisis or storm
       E05.11 Thyrotoxicosis with toxic single thyroid nodule with thyrotoxic crisis or storm
    E05.2 Thyrotoxicosis with toxic multinodular goiter
       Toxic nodular goiter NOS
       E05.20 Thyrotoxicosis with toxic multinodular goiter without thyrotoxic crisis or storm
       E05.21 Thyrotoxicosis with toxic multinodular goiter with thyrotoxic crisis or storm
    E05.3 Thyrotoxicosis from ectopic thyroid tissue
       E05.30 Thyrotoxicosis from ectopic thyroid tissue without thyrotoxic crisis or storm
       E05.31 Thyrotoxicosis from ectopic thyroid tissue with thyrotoxic crisis or storm
    E05.4 Thyrotoxicosis factitia
       E05.40 Thyrotoxicosis factitia without thyrotoxic crisis or storm
       E05.41 Thyrotoxicosis factitia with thyrotoxic crisis or storm
    E05.8 Other thyrotoxicosis
       Overproduction ​of thyroid-stimulating hormone
       E05.80 Other thyrotoxicosis without thyrotoxic crisis or storm
       E05.81 Other thyrotoxicosis with thyrotoxic crisis or storm
    E05.9 Thyrotoxicosis, unspecified
       Hyperthyroidism NOS
       E05.90 Thyrotoxicosis, unspecified without thyrotoxic crisis or storm
       E05.91 Thyrotoxicosis, unspecified with thyrotoxic crisis or storm

## E06 ThyroiditisE06 Thyroiditis

    Excludes1: postpartum thyroiditis (O90.5)
    E06.0 Acute thyroiditis
       Abscess of thyroid
       Pyogenic thyroiditis
       Suppurative thyroiditis
       Use additional code (B95-B97) to identify infectious agent.
    E06.1 Subacute thyroiditis
       de Quervain thyroiditis
       Giant-cell thyroiditis
       Granulomatous thyroiditis
       Nonsuppurative thyroiditis
       Viral thyroiditis
       Excludes1: autoimmune thyroiditis (E06.3)
    E06.2 Chronic thyroiditis with transient thyrotoxicosis
       Excludes1: autoimmune thyroiditis (E06.3)
    E06.3 Autoimmune thyroiditis
       Hashimoto's thyroiditis
       Hashitoxicosis (transient)
       Lymphadenoid goiter
       Lymphocytic thyroiditis
       Struma lymphomatosa
    E06.4 Drug-induced thyroiditis
       Code first (T36-T50) to identify drug
    E06.5 Other chronic thyroiditis
       Chronic fibrous thyroiditis
       Chronic thyroiditis NOS
       Ligneous thyroiditis
       Riedel thyroiditis
    E06.9 Thyroiditis, unspecified

## E07 Other disorders of thyroidE07 Other disorders of thyroid

    E07.0 Hypersecretion of calcitonin
       C-cell hyperplasia of thyroid
       Hypersecretion of thyrocalcitonin
    E07.1 Dyshormogenetic goiter
       Familial dyshormogenetic goiter
       Pendred' ​s syndrome
       Excludes1: transitory congenital goiter with normal function (P72.0)
    E07.8 Other specified disorders of thyroid
       E07.81 Sick-euthyroid syndrome
          Euthyroid sick-syndrome
       E07.89 Other specified disorders of thyroid
          Abnormality of thyroid-binding globulin
          Hemorrhage of thyroid
          Infarction of thyroid
    E07.9 Disorder of thyroid, unspecified

# Diabetes mellitus (E08-E13)Diabetes mellitus (E08-E13)
## E08 Diabetes mellitus due to underlying conditionE08 Diabetes mellitus due to underlying condition

    Code first the underlying condition, such as:
       Congenital rubella (P35.0)
       Cushing's syndrome (E24.-)
       Cystic fibrosis (E84.-)
       Malignant neoplasm (C00-C96)
       Malnutrition (E40-E46)
       Pancreatitis and other diseases of the pancreas (K85-K86.-)
    Use additional code to identify any insulin use (Z79.4)
    Excludes1: drug or chemical induced diabetes mellitus (E09.-)
       gestational diabetes (O24.4-)
       neonatal diabetes mellitus (P70.2)
       type 1 diabetes mellitus (E10.-)
       type 2 diabetes mellitus (E11.-)
    E08.0 Diabetes mellitus due to underlying condition with hyperosmolarity
       E08.00 Diabetes mellitus due to underlying condition with hyperosmolarity without nonketotic hyperglycemic-hyperosmolar coma (NKHHC)
       E08.01 Diabetes mellitus due to underlying condition with hyperosmolarity with coma
    E08.1 Diabetes mellitus due to underlying condition with ketoacidosis
       E08.10 Diabetes mellitus due to underlying condition with ketoacidosis without coma
       E08.11 Diabetes mellitus due to underlying condition with ketoacidosis with coma
    E08.2 Diabetes mellitus due to underlying condition with kidney complications
       E08.21 Diabetes mellitus due to underlying condition with diabetic nephropathy
          Diabetes ​mellitus due to underlying condition with intercapillary glomerulosclerosis
          Diabetes mellitus due to underlying condition with intracapillary glomerulonephrosis
          Diabetes mellitus due to underlying condition with Kimmelstiel-Wilson disease
       E08.22 Diabetes mellitus due to underlying condition with diabetic chronic kidney disease
          Diabetes mellitus due to underlying condition with chronic kidney disease due to conditions classified to .21 and .22
          Use additional code to identify stage of chronic kidney disease (N18.1-N18.6)
       E08.29 Diabetes mellitus due to underlying condition with other diabetic kidney complication
          Renal tubular degeneration in diabetes mellitus due to underlying condition
    E08.3 Diabetes mellitus due to underlying condition with ophthalmic complications
       E08.31 Diabetes mellitus due to underlying condition with unspecified diabetic retinopathy
          E08.311 Diabetes mellitus due to underlying condition with unspecified diabetic retinopathy with macular edema
          E08.319 Diabetes mellitus due to underlying condition with unspecified diabetic retinopathy without macular edema
       E08.32 Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy
          Diabetes mellitus due to underlying condition with nonproliferative diabetic retinopathy NOS
          E08.321 Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy with macular edema
          E08.329 Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy without macular edema
       E08.33 Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy
          E08.331 Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy with macular edema
          E08. ​339 Diabetes mellitus due to underlying condition with moderate nonproliferative diabetic retinopathy without macular edema
       E08.34 Diabetes mellitus due to underlying condition with severe nonproliferative diabetic retinopathy
          E08.341 Diabetes mellitus due to underlying condition with severe nonproliferative diabetic retinopathy with macular edema
          E08.349 Diabetes mellitus due to underlying condition with severe nonproliferative diabetic retinopathy without macular edema
       E08.35 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy
          E08.351 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy with macular edema
          E08.359 Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy without macular edema
       E08.36 Diabetes mellitus due to underlying condition with diabetic cataract
       E08.39 Diabetes mellitus due to underlying condition with other diabetic ophthalmic complication
    E08.4 Diabetes mellitus due to underlying condition with neurological complications
       E08.40 Diabetes mellitus due to underlying condition with diabetic neuropathy, unspecified
       E08.41 Diabetes mellitus due to underlying condition with diabetic mononeuropathy
       E08.42 Diabetes mellitus due to underlying condition with diabetic polyneuropathy
          Diabetes mellitus due to underlying condition with diabetic neuralgia
       E08.43 Diabetes mellitus due to underlying condition with diabetic autonomic (poly)neuropathy
          Diabetes mellitus due to underlying condition with diabetic gastroparesis
       E08.44 Diabetes mellitus due to underlying condition with diabetic amyotrophy
       E08.49 Diabetes mellitus due to underlying condition with other diabetic neurological complication
    E08.5 Diabetes mellitus due to underlying condition with circulatory complications
       E08.51 Diabetes mellitus due to underlying condition with diabetic peripheral angiopathy without gangrene
       E08. ​52 Diabetes mellitus due to underlying condition with diabetic peripheral angiopathy with gangrene
          Diabetes mellitus due to underlying condition with diabetic gangrene
       E08.59 Diabetes mellitus due to underlying condition with other circulatory complications
    E08.6 Diabetes mellitus due to underlying condition with other specified complications
       E08.61 Diabetes mellitus due to underlying condition with diabetic arthropathy
          E08.610 Diabetes mellitus due to underlying condition with diabetic neuropathic arthropathy
             Diabetes mellitus due to underlying condition with Charcot's joints
          E08.618 Diabetes mellitus due to underlying condition with other diabetic arthropathy
       E08.62 Diabetes mellitus due to underlying condition with skin complications
          E08.620 Diabetes mellitus due to underlying condition with diabetic dermatitis
             Diabetes mellitus due to underlying condition with diabetic necrobiosis lipoidica
          E08.621 Diabetes mellitus due to underlying condition with foot ulcer
             Use additional code to identify site of ulcer (L97.4-, L97.5-)
          E08.622 Diabetes mellitus due to underlying condition with other skin ulcer
             Use additional code to identify site of ulcer (L97.1-L97.9, L98.41-L98.49)
          E08.628 Diabetes mellitus due to underlying condition with other skin complications
       E08.63 Diabetes mellitus due to underlying condition with oral complications
          E08.630 Diabetes mellitus due to underlying condition with periodontal disease
          E08.638 Diabetes mellitus due to underlying condition with other oral complications
       E08.64 Diabetes mellitus due to underlying condition with hypoglycemia
          E08.641 Diabetes mellitus due to underlying condition with hypoglycemia with coma
          E08.649 Diabetes mellitus due to underlying condition with hypoglycemia without coma
       E08. ​65 Diabetes mellitus due to underlying condition with hyperglycemia
       E08.69 Diabetes mellitus due to underlying condition with other specified complication
          Use additional code to identify complication
    E08.8 Diabetes mellitus due to underlying condition with unspecified complications
    E08.9 Diabetes mellitus due to underlying condition without complications

## E09 Drug or chemical induced diabetes mellitusE09 Drug or chemical induced diabetes mellitus

    Code first (T36-T65) to identify drug or chemical
    Use additional code to identify any insulin use (Z79.4)
    Excludes1: diabetes mellitus due to underlying condition (E08.-)
       gestational diabetes (O24.4-)
       neonatal diabetes mellitus (P70.2)
       type 1 diabetes mellitus (E10.-)
       type 2 diabetes mellitus (E11.-)
    E09.0 Drug or chemical induced diabetes mellitus with hyperosmolarity
       E09.00 Drug or chemical induced diabetes mellitus with hyperosmolarity without nonketotic hyperglycemic-hyperosmolar coma (NKHHC)
       E09.01 Drug or chemical induced diabetes mellitus with hyperosmolarity with coma
    E09.1 Drug or chemical induced diabetes mellitus with ketoacidosis
       E09.10 Drug or chemical induced diabetes mellitus with ketoacidosis without coma
       E09.11 Drug or chemical induced diabetes mellitus with ketoacidosis with coma
    E09.2 Drug or chemical induced diabetes mellitus with kidney complications
       E09.21 Drug or chemical induced diabetes mellitus with diabetic nephropathy
          Drug or chemical induced diabetes mellitus with intercapillary glomerulosclerosis
          Drug or chemical induced diabetes mellitus with intracapillary glomerulonephrosis
          Drug or chemical induced diabetes mellitus with Kimmelstiel-Wilson disease
       E09.22 Drug or chemical induced diabetes mellitus with diabetic chronic kidney disease
          Drug or chemical induced diabetes mellitus with chronic kidney disease due to conditions classified to .21 and .22
          Use additional code to identify stage of chronic kidney disease (N18.1-N18.6)
       E09. ​29 Drug or chemical induced diabetes mellitus with other diabetic kidney complication
          Drug or chemical induced diabetes mellitus with renal tubular degeneration
    E09.3 Drug or chemical induced diabetes mellitus with ophthalmic complications
       E09.31 Drug or chemical induced diabetes mellitus with unspecified diabetic retinopathy
          E09.311 Drug or chemical induced diabetes mellitus with unspecified diabetic retinopathy with macular edema
          E09.319 Drug or chemical induced diabetes mellitus with unspecified diabetic retinopathy without macular edema
       E09.32 Drug or chemical induced diabetes mellitus with mild nonproliferative diabetic retinopathy
          Drug or chemical induced diabetes mellitus with nonproliferative diabetic retinopathy NOS
          E09.321 Drug or chemical induced diabetes mellitus with mild nonproliferative diabetic retinopathy with macular edema
          E09.329 Drug or chemical induced diabetes mellitus with mild nonproliferative diabetic retinopathy without macular edema
       E09.33 Drug or chemical induced diabetes mellitus with moderate nonproliferative diabetic retinopathy
          E09.331 Drug or chemical induced diabetes mellitus with moderate nonproliferative diabetic retinopathy with macular edema
          E09.339 Drug or chemical induced diabetes mellitus with moderate nonproliferative diabetic retinopathy without macular edema
       E09.34 Drug or chemical induced diabetes mellitus with severe nonproliferative diabetic retinopathy
          E09.341 Drug or chemical induced diabetes mellitus with severe nonproliferative diabetic retinopathy with macular edema
          E09.349 Drug or chemical induced diabetes mellitus with severe nonproliferative diabetic retinopathy without macular edema
       E09.35 Drug or chemical induced diabetes mellitus with proliferative diabetic retinopathy
          E09.351 Drug or chemical induced diabetes mellitus with proliferative diabetic retinopathy with macular edema
          E09. ​359 Drug or chemical induced diabetes mellitus with proliferative diabetic retinopathy without macular edema
       E09.36 Drug or chemical induced diabetes mellitus with diabetic cataract
       E09.39 Drug or chemical induced diabetes mellitus with other diabetic ophthalmic complication
    E09.4 Drug or chemical induced diabetes mellitus with neurological complications
       E09.40 Drug or chemical induced diabetes mellitus with neurological complications with diabetic neuropathy, unspecified
       E09.41 Drug or chemical induced diabetes mellitus with neurological complications with diabetic mononeuropathy
       E09.42 Drug or chemical induced diabetes mellitus with neurological complications with diabetic polyneuropathy
          Drug or chemical induced diabetes mellitus with diabetic neuralgia
       E09.43 Drug or chemical induced diabetes mellitus with neurological complications with diabetic autonomic (poly)neuropathy
          Drug or chemical induced diabetes mellitus with diabetic gastroparesis
       E09.44 Drug or chemical induced diabetes mellitus with neurological complications with diabetic amyotrophy
       E09.49 Drug or chemical induced diabetes mellitus with neurological complications with other diabetic neurological complication
    E09.5 Drug or chemical induced diabetes mellitus with circulatory complications
       E09.51 Drug or chemical induced diabetes mellitus with diabetic peripheral angiopathy without gangrene
       E09.52 Drug or chemical induced diabetes mellitus with diabetic peripheral angiopathy with gangrene
          Drug or chemical induced diabetes mellitus with diabetic gangrene
       E09.59 Drug or chemical induced diabetes mellitus with other circulatory complications
    E09.6 Drug or chemical induced diabetes mellitus with other specified complications
       E09.61 Drug or chemical induced diabetes mellitus with diabetic arthropathy
          E09.610 Drug or chemical induced diabetes mellitus with diabetic neuropathic arthropathy
             Drug ​or chemical induced diabetes mellitus with Charcot's joints
          E09.618 Drug or chemical induced diabetes mellitus with other diabetic arthropathy
       E09.62 Drug or chemical induced diabetes mellitus with skin complications
          E09.620 Drug or chemical induced diabetes mellitus with diabetic dermatitis
             Drug or chemical induced diabetes mellitus with diabetic necrobiosis lipoidica
          E09.621 Drug or chemical induced diabetes mellitus with foot ulcer
             Use additional code to identify site of ulcer (L97.4-, L97.5-)
          E09.622 Drug or chemical induced diabetes mellitus with other skin ulcer
             Use additional code to identify site of ulcer (L97.1-L97.9, L98.41-L98.49)
          E09.628 Drug or chemical induced diabetes mellitus with other skin complications
       E09.63 Drug or chemical induced diabetes mellitus with oral complications
          E09.630 Drug or chemical induced diabetes mellitus with periodontal disease
          E09.638 Drug or chemical induced diabetes mellitus with other oral complications
       E09.64 Drug or chemical induced diabetes mellitus with hypoglycemia
          E09.641 Drug or chemical induced diabetes mellitus with hypoglycemia with coma
          E09.649 Drug or chemical induced diabetes mellitus with hypoglycemia without coma
       E09.65 Drug or chemical induced diabetes mellitus with hyperglycemia
       E09.69 Drug or chemical induced diabetes mellitus with other specified complication
          Use additional code to identify complication
    E09.8 Drug or chemical induced diabetes mellitus with unspecified complications
    E09.9 Drug or chemical induced diabetes mellitus without complications

## E10 Type 1 diabetes mellitusE10 Type 1 diabetes mellitus

    Includes: brittle diabetes (mellitus)
       diabetes (mellitus) due to autoimmune process
       diabetes (mellitus) due to immune mediated pancreatic islet beta-cell destruction
       idiopathic ​diabetes (mellitus)
       juvenile onset diabetes (mellitus)
       ketosis-prone diabetes (mellitus)
    Excludes1: diabetes mellitus due to underlying condition (E08.-)
       drug or chemical induced diabetes mellitus (E09.-)
       gestational diabetes (O24.4-)
       hyperglycemia NOS (R73.9)
       neonatal diabetes mellitus (P70.2)
       type 2 diabetes mellitus (E11.-)
    E10.1 Type 1 diabetes mellitus with ketoacidosis
       E10.10 Type 1 diabetes mellitus with ketoacidosis without coma
       E10.11 Type 1 diabetes mellitus with ketoacidosis with coma
    E10.2 Type 1 diabetes mellitus with kidney complications
       E10.21 Type 1 diabetes mellitus with diabetic nephropathy
          Type 1 diabetes mellitus with intercapillary glomerulosclerosis
          Type 1 diabetes mellitus with intracapillary glomerulonephrosis
          Type 1 diabetes mellitus with Kimmelstiel-Wilson disease
       E10.22 Type 1 diabetes mellitus with diabetic chronic kidney disease
          Type 1 diabetes mellitus with chronic kidney disease due to conditions classified to .21 and .22
          Use additional code to identify stage of chronic kidney disease (N18.1-N18.6)
       E10.29 Type 1 diabetes mellitus with other diabetic kidney complication
          Type 1 diabetes mellitus with renal tubular degeneration
    E10.3 Type 1 diabetes mellitus with ophthalmic complications
       E10.31 Type 1 diabetes mellitus with unspecified diabetic retinopathy
          E10.311 Type 1 diabetes mellitus with unspecified diabetic retinopathy with macular edema
          E10.319 Type 1 diabetes mellitus with unspecified diabetic retinopathy without macular edema
       E10.32 Type 1 diabetes mellitus with mild nonproliferative diabetic retinopathy
          Type 1 diabetes mellitus with nonproliferative diabetic retinopathy NOS
          E10.321 Type 1 diabetes mellitus with mild nonproliferative diabetic retinopathy with macular edema
          E10.329 Type 1 diabetes mellitus with mild nonproliferative diabetic retinopathy without macular edema
       E10. ​33 Type 1 diabetes mellitus with moderate nonproliferative diabetic retinopathy
          E10.331 Type 1 diabetes mellitus with moderate nonproliferative diabetic retinopathy with macular edema
          E10.339 Type 1 diabetes mellitus with moderate nonproliferative diabetic retinopathy without macular edema
       E10.34 Type 1 diabetes mellitus with severe nonproliferative diabetic retinopathy
          E10.341 Type 1 diabetes mellitus with severe nonproliferative diabetic retinopathy with macular edema
          E10.349 Type 1 diabetes mellitus with severe nonproliferative diabetic retinopathy without macular edema
       E10.35 Type 1 diabetes mellitus with proliferative diabetic retinopathy
          E10.351 Type 1 diabetes mellitus with proliferative diabetic retinopathy with macular edema
          E10.359 Type 1 diabetes mellitus with proliferative diabetic retinopathy without macular edema
       E10.36 Type 1 diabetes mellitus with diabetic cataract
       E10.39 Type 1 diabetes mellitus with other diabetic ophthalmic complication
    E10.4 Type 1 diabetes mellitus with neurological complications
       E10.40 Type 1 diabetes mellitus with diabetic neuropathy, unspecified
       E10.41 Type 1 diabetes mellitus with diabetic mononeuropathy
       E10.42 Type 1 diabetes mellitus with diabetic polyneuropathy
          Type 1 diabetes mellitus with diabetic neuralgia
       E10.43 Type 1 diabetes mellitus with diabetic autonomic (poly)neuropathy
          Type 1 diabetes mellitus with diabetic gastroparesis
       E10.44 Type 1 diabetes mellitus with diabetic amyotrophy
       E10.49 Type 1 diabetes mellitus with other diabetic neurological complication
    E10.5 Type 1 diabetes mellitus with circulatory complications
       E10.51 Type 1 diabetes mellitus with diabetic peripheral angiopathy without gangrene
       E10.52 Type 1 diabetes mellitus with diabetic peripheral angiopathy with gangrene
          Type 1 diabetes mellitus with diabetic gangrene
       E10.59 Type 1 diabetes mellitus with other circulatory complications
    E10. ​6 Type 1 diabetes mellitus with other specified complications
       E10.61 Type 1 diabetes mellitus with diabetic arthropathy
          E10.610 Type 1 diabetes mellitus with diabetic neuropathic arthropathy
             Type 1 diabetes mellitus with Charcot's joints
          E10.618 Type 1 diabetes mellitus with other diabetic arthropathy
       E10.62 Type 1 diabetes mellitus with skin complications
          E10.620 Type 1 diabetes mellitus with diabetic dermatitis
             Type 1 diabetes mellitus with diabetic necrobiosis lipoidica
          E10.621 Type 1 diabetes mellitus with foot ulcer
             Use additional code to identify site of ulcer (L97.4-, L97.5-)
          E10.622 Type 1 diabetes mellitus with other skin ulcer
             Use additional code to identify site of ulcer (L97.1-L97.9, L98.41-L98.49)
          E10.628 Type 1 diabetes mellitus with other skin complications
       E10.63 Type 1 diabetes mellitus with oral complications
          E10.630 Type 1 diabetes mellitus with periodontal disease
          E10.638 Type 1 diabetes mellitus with other oral complications
       E10.64 Type 1 diabetes mellitus with hypoglycemia
          E10.641 Type 1 diabetes mellitus with hypoglycemia with coma
          E10.649 Type 1 diabetes mellitus with hypoglycemia without coma
       E10.65 Type 1 diabetes mellitus with hyperglycemia
       E10.69 Type 1 diabetes mellitus with other specified complication
          Use additional code to identify complication
    E10.8 Type 1 diabetes mellitus with unspecified complications
    E10.9 Type 1 diabetes mellitus without complications

## E11 Type 2 diabetes mellitusE11 Type 2 diabetes mellitus

    Includes: diabetes (mellitus) due to insulin secretory defect
       diabetes NOS
       insulin resistant diabetes (mellitus)
    Use additional code to identify any insulin use (Z79.4)
    Excludes1: diabetes mellitus due to underlying condition (E08.-)
       drug ​or chemical induced diabetes mellitus (E09.-)
       gestational diabetes (O24.4-)
       neonatal diabetes mellitus (P70.2)
       type 1 diabetes mellitus (E10.-)
    E11.0 Type 2 diabetes mellitus with hyperosmolarity
       E11.00 Type 2 diabetes mellitus with hyperosmolarity without nonketotic hyperglycemic-hyperosmolar coma (NKHHC)
       E11.01 Type 2 diabetes mellitus with hyperosmolarity with coma
    E11.2 Type 2 diabetes mellitus with kidney complications
       E11.21 Type 2 diabetes mellitus with diabetic nephropathy
          Type 2 diabetes mellitus with intercapillary glomerulosclerosis
          Type 2 diabetes mellitus with intracapillary glomerulonephrosis
          Type 2 diabetes mellitus with Kimmelstiel-Wilson disease
       E11.22 Type 2 diabetes mellitus with diabetic chronic kidney disease
          Type 2 diabetes mellitus with chronic kidney disease due to conditions classified to .21 and .22
          Use additional code to identify stage of chronic kidney disease (N18.1-N18.6)
       E11.29 Type 2 diabetes mellitus with other diabetic kidney complication
          Type 2 diabetes mellitus with renal tubular degeneration
    E11.3 Type 2 diabetes mellitus with ophthalmic complications
       E11.31 Type 2 diabetes mellitus with unspecified diabetic retinopathy
          E11.311 Type 2 diabetes mellitus with unspecified diabetic retinopathy with macular edema
          E11.319 Type 2 diabetes mellitus with unspecified diabetic retinopathy without macular edema
       E11.32 Type 2 diabetes mellitus with mild nonproliferative diabetic retinopathy
          Type 2 diabetes mellitus with nonproliferative diabetic retinopathy NOS
          E11.321 Type 2 diabetes mellitus with mild nonproliferative diabetic retinopathy with macular edema
          E11.329 Type 2 diabetes mellitus with mild nonproliferative diabetic retinopathy without macular edema
       E11.33 Type 2 diabetes mellitus with moderate nonproliferative diabetic retinopathy
          E11. ​331 Type 2 diabetes mellitus with moderate nonproliferative diabetic retinopathy with macular edema
          E11.339 Type 2 diabetes mellitus with moderate nonproliferative diabetic retinopathy without macular edema
       E11.34 Type 2 diabetes mellitus with severe nonproliferative diabetic retinopathy
          E11.341 Type 2 diabetes mellitus with severe nonproliferative diabetic retinopathy with macular edema
          E11.349 Type 2 diabetes mellitus with severe nonproliferative diabetic retinopathy without macular edema
       E11.35 Type 2 diabetes mellitus with proliferative diabetic retinopathy
          E11.351 Type 2 diabetes mellitus with proliferative diabetic retinopathy with macular edema
          E11.359 Type 2 diabetes mellitus with proliferative diabetic retinopathy without macular edema
       E11.36 Type 2 diabetes mellitus with diabetic cataract
       E11.39 Type 2 diabetes mellitus with other diabetic ophthalmic complication
    E11.4 Type 2 diabetes mellitus with neurological comp``lications
       E11.40 Type 2 diabetes mellitus with diabetic neuropathy, unspecified
       E11.41 Type 2 diabetes mellitus with diabetic mononeuropathy
       E11.42 Type 2 diabetes mellitus with diabetic polyneuropathy
          Type 2 diabetes mellitus with diabetic neuralgia
       E11.43 Type 2 diabetes mellitus with diabetic autonomic (poly)neuropathy
          Type 2 diabetes mellitus with diabetic gastroparesis
       E11.44 Type 2 diabetes mellitus with diabetic amyotrophy
       E11.49 Type 2 diabetes mellitus with other diabetic neurological complication
    E11.5 Type 2 diabetes mellitus with circulatory complications
       E11.51 Type 2 diabetes mellitus with diabetic peripheral angiopathy without gangrene
       E11.52 Type 2 diabetes mellitus with diabetic peripheral angiopathy with gangrene
          Type 2 diabetes mellitus with diabetic gangrene
       E11.59 Type 2 diabetes mellitus with other circulatory complications
    E11.6 Type 2 diabetes mellitus with other specified complications
       E11. ​61 Type 2 diabetes mellitus with diabetic arthropathy
          E11.610 Type 2 diabetes mellitus with diabetic neuropathic arthropathy
             Type 2 diabetes mellitus with Charcot's joints
          E11.618 Type 2 diabetes mellitus with other diabetic arthropathy
       E11.62 Type 2 diabetes mellitus with skin complications
          E11.620 Type 2 diabetes mellitus with diabetic dermatitis
             Type 2 diabetes mellitus with diabetic necrobiosis lipoidica
          E11.621 Type 2 diabetes mellitus with foot ulcer
             Use additional code to identify site of ulcer (L97.4-, L97.5-)
          E11.622 Type 2 diabetes mellitus with other skin ulcer
             Use additional code to identify site of ulcer (L97.1-L97.9, L98.41-L98.49)
          E11.628 Type 2 diabetes mellitus with other skin complications
       E11.63 Type 2 diabetes mellitus with oral complications
          E11.630 Type 2 diabetes mellitus with periodontal disease
          E11.638 Type 2 diabetes mellitus with other oral complications
       E11.64 Type 2 diabetes mellitus with hypoglycemia
          E11.641 Type 2 diabetes mellitus with hypoglycemia with coma
          E11.649 Type 2 diabetes mellitus with hypoglycemia without coma
       E11.65 Type 2 diabetes mellitus with hyperglycemia
       E11.69 Type 2 diabetes mellitus with other specified complication
          Use additional code to identify complication
    E11.8 Type 2 diabetes mellitus with unspecified complications
    E11.9 Type 2 diabetes mellitus without complications

## E13 Other specified diabetes mellitusE13 Other specified diabetes mellitus

    Includes: diabetes mellitus due to genetic defects of beta-cell function
       diabetes mellitus due to genetic defects in insulin action
    Use additional code to identify any insulin use (Z79.4)
    Excludes1: diabetes (mellitus) due to autoimmune process (E10.-)
       diabetes (mellitus) due to immune mediated pancreatic islet beta-cell destruction (E10.-)
       diabetes ​mellitus due to underlying condition (E08.-)
       drug or chemical induced diabetes mellitus (E09.-)
       gestational diabetes (O24.44)
       neonatal diabetes mellitus (P70.2)
       type 2 diabetes mellitus (E11.-)
    E13.0 Other specified diabetes mellitus with hyperosmolarity
       E13.00 Other specified diabetes mellitus with hyperosmolarity without nonketotic hyperglycemic-hyperosmolar coma (NKHHC)
       E13.01 Other specified diabetes mellitus with hyperosmolarity with coma
    E13.1 Other specified diabetes mellitus with ketoacidosis
       E13.10 Other specified diabetes mellitus with ketoacidosis without coma
       E13.11 Other specified diabetes mellitus with ketoacidosis with coma
    E13.2 Other specified diabetes mellitus with kidney complications
       E13.21 Other specified diabetes mellitus with diabetic nephropathy
          Other specified diabetes mellitus with intercapillary glomerulosclerosis
          Other specified diabetes mellitus with intracapillary glomerulonephrosis
          Other specified diabetes mellitus with Kimmelstiel-Wilson disease
       E13.22 Other specified diabetes mellitus with diabetic chronic kidney disease
          Other specified diabetes mellitus with chronic kidney disease due to conditions classified to .21 and .22
          Use additional code to identify stage of chronic kidney disease (N18.1-N18.6)
       E13.29 Other specified diabetes mellitus with other diabetic kidney complication
          Other specified diabetes mellitus with renal tubular degeneration
    E13.3 Other specified diabetes mellitus with ophthalmic complications
       E13.31 Other specified diabetes mellitus with unspecified diabetic retinopathy
          E13.311 Other specified diabetes mellitus with unspecified diabetic retinopathy with macular edema
          E13.319 Other specified diabetes mellitus with unspecified diabetic retinopathy without macular edema
       E13. ​32 Other specified diabetes mellitus with mild nonproliferative diabetic retinopathy
          Other specified diabetes mellitus with nonproliferative diabetic retinopathy NOS
          E13.321 Other specified diabetes mellitus with mild nonproliferative diabetic retinopathy with macular edema
          E13.329 Other specified diabetes mellitus with mild nonproliferative diabetic retinopathy without macular edema
       E13.33 Other specified diabetes mellitus with moderate nonproliferative diabetic retinopathy
          E13.331 Other specified diabetes mellitus with moderate nonproliferative diabetic retinopathy with macular edema
          E13.339 Other specified diabetes mellitus with moderate nonproliferative diabetic retinopathy without macular edema
       E13.34 Other specified diabetes mellitus with severe nonproliferative diabetic retinopathy
          E13.341 Other specified diabetes mellitus with severe nonproliferative diabetic retinopathy with macular edema
          E13.349 Other specified diabetes mellitus with severe nonproliferative diabetic retinopathy without macular edema
       E13.35 Other specified diabetes mellitus with proliferative diabetic retinopathy
          E13.351 Other specified diabetes mellitus with proliferative diabetic retinopathy with macular edema
          E13.359 Other specified diabetes mellitus with proliferative diabetic retinopathy without macular edema
       E13.36 Other specified diabetes mellitus with diabetic cataract
       E13.39 Other specified diabetes mellitus with other diabetic ophthalmic complication
    E13.4 Other specified diabetes mellitus with neurological complications
       E13.40 Other specified diabetes mellitus with diabetic neuropathy, unspecified
       E13.41 Other specified diabetes mellitus with diabetic mononeuropathy
       E13.42 Other specified diabetes mellitus with diabetic polyneuropathy
          Other specified diabetes mellitus with diabetic neuralgia
       E13. ​43 Other specified diabetes mellitus with diabetic autonomic (poly)neuropathy
          Other specified diabetes mellitus with diabetic gastroparesis
       E13.44 Other specified diabetes mellitus with diabetic amyotrophy
       E13.49 Other specified diabetes mellitus with other diabetic neurological complication
    E13.5 Other specified diabetes mellitus with circulatory complications
       E13.51 Other specified diabetes mellitus with diabetic peripheral angiopathy without gangrene
       E13.52 Other specified diabetes mellitus with diabetic peripheral angiopathy with gangrene
          Other specified diabetes mellitus with diabetic gangrene
       E13.59 Other specified diabetes mellitus with other circulatory complications
    E13.6 Other specified diabetes mellitus with other specified complications
       E13.61 Other specified diabetes mellitus with diabetic arthropathy
          E13.610 Other specified diabetes mellitus with diabetic neuropathic arthropathy
             Other specified diabetes mellitus with Charcot's joints
          E13.618 Other specified diabetes mellitus with other diabetic arthropathy
       E13.62 Other specified diabetes mellitus with skin complications
          E13.620 Other specified diabetes mellitus with diabetic dermatitis
             Other specified diabetes mellitus with diabetic necrobiosis lipoidica
          E13.621 Other specified diabetes mellitus with foot ulcer
             Use additional code to identify site of ulcer (L97.4-, L97.5-)
          E13.622 Other specified diabetes mellitus with other skin ulcer
             Use additional code to identify site of ulcer (L97.1-L97.9, L98.41-L98.49)
          E13.628 Other specified diabetes mellitus with other skin complications
       E13.63 Other specified diabetes mellitus with oral complications
          E13.630 Other specified diabetes mellitus with periodontal disease
          E13. ​638 Other specified diabetes mellitus with other oral complications
       E13.64 Other specified diabetes mellitus with hypoglycemia
          E13.641 Other specified diabetes mellitus with hypoglycemia with coma
          E13.649 Other specified diabetes mellitus with hypoglycemia without coma
       E13.65 Other specified diabetes mellitus with hyperglycemia
       E13.69 Other specified diabetes mellitus with other specified complication
          Use additional code to identify complication
    E13.8 Other specified diabetes mellitus with unspecified complications
    E13.9 Other specified diabetes mellitus without complications

# Other disorders of glucose regulation and pancreatic internal secretion (E15-E16)Other disorders of glucose regulation and pancreatic internal secretion (E15-E16)
## E15 Nondiabetic hypoglycemic comaE15 Nondiabetic hypoglycemic coma

    Includes: drug-induced insulin coma in nondiabetic
       hyperinsulinism with hypoglycemic coma
       hypoglycemic coma NOS

## E16 Other disorders of pancreatic internal secretionE16 Other disorders of pancreatic internal secretion

    E16.0 Drug-induced hypoglycemia without coma
       Code first (T36-T50) to identify drug
    E16.1 Other hypoglycemia
       Functional hyperinsulinism
       Functional nonhyperinsulinemic hypoglycemia
       Hyperinsulinism NOS
       Hyperplasia of pancreatic islet beta cells NOS
       Excludes1: hypoglycemia in infant of diabetic mother (P70.1)
          neonatal hypoglycemia (P70.4)
    E16.2 Hypoglycemia, unspecified
    E16.3 Increased secretion of glucagon
       Hyperplasia of pancreatic endocrine cells with glucagon excess
    E16.4 Increased secretion of gastrin
       Hypergastrinemia
       Hyperplasia of pancreatic endocrine cells with gastrin excess
       Zollinger-Ellison syndrome
    E16.8 Other specified disorders of pancreatic internal secretion
       Increased secretion from endocrine pancreas of growth hormone-releasing hormone
       Increased secretion from endocrine pancreas of pancreatic polypeptide
       Increased ​secretion from endocrine pancreas of somatostatin
       Increased secretion from endocrine pancreas of vasoactive-intestinal polypeptide
    E16.9 Disorder of pancreatic internal secretion, unspecified
       Islet-cell hyperplasia NOS
       Pancreatic endocrine cell hyperplasia NOS

# Disorders of other endocrine glands (E20-E35)Disorders of other endocrine glands (E20-E35)

    Excludes1: galactorrhea (N64.3)
       gynecomastia (N62)

## E20 HypoparathyroidismE20 Hypoparathyroidism

    Excludes1: Di George's syndrome (D82.1)
       postprocedural hypoparathyroidism (E89.2)
       tetany NOS (R29.0 )
       transitory neonatal hypoparathyroidism (P71.4)
    E20.0 Idiopathic hypoparathyroidism
    E20.1 Pseudohypoparathyroidism
    E20.8 Other hypoparathyroidism
    E20.9 Hypoparathyroidism, unspecified
       Parathyroid tetany

## E21 Hyperparathyroidism and other disorders of parathyroid glandE21 Hyperparathyroidism and other disorders of parathyroid gland

    Excludes1: adult osteomalacia (M83.-)
       ectopic hyperparathyroidism (E34.2)
       familial hypocalciuric hypercalcemia (E83.52)
       hungry bone syndrome (E83.81)
       infantile and juvenile osteomalacia (E55.0)
    E21.0 Primary hyperparathyroidism
       Hyperplasia of parathyroid
       Osteitis fibrosa cystica generalisata [von Recklinghausen's disease of bone]
    E21.1 Secondary hyperparathyroidism, not elsewhere classified
       Excludes1: secondary hyperparathyroidism of renal origin (N25.81)
    E21.2 Other hyperparathyroidism
       Tertiary hyperparathyroidism
       Excludes1: familial hypocalciuric hypercalcemia (E83.52)
    E21.3 Hyperparathyroidism, unspecified
    E21.4 Other specified disorders of parathyroid gland
    E21.5 Disorder of parathyroid gland, unspecified

## E22 Hyperfunction of pituitary glandE22 Hyperfunction of pituitary gland

    Excludes1: Cushing's syndrome (E24.-)
       Nelson's syndrome (E24.1)
       overproduction ​of ACTH not associated with Cushing's disease (E27.0)
       overproduction of pituitary ACTH (E24.0)
       overproduction of thyroid-stimulating hormone (E05.8-)
    E22.0 Acromegaly and pituitary gigantism
       Overproduction of growth hormone
       Excludes1: constitutional gigantism (E34.4)
          constitutional tall stature (E34.4)
          increased secretion from endocrine pancreas of growth hormone-releasing hormone (E16.8)
    E22.1 Hyperprolactinemia
    E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
    E22.8 Other hyperfunction of pituitary gland
       Central precocious puberty
    E22.9 Hyperfunction of pituitary gland, unspecified

## E23 Hypofunction and other disorders of the pituitary glandE23 Hypofunction and other disorders of the pituitary gland

    Includes: the listed conditions whether the disorder is in the pituitary or the hypothalamus
    Excludes1: postprocedural hypopituitarism (E89.3)
    E23.0 Hypopituitarism
       Fertile eunuch syndrome
       Hypogonadotropic hypogonadism
       Idiopathic growth hormone deficiency
       Isolated deficiency of gonadotropin
       Isolated deficiency of growth hormone
       Isolated deficiency of pituitary hormone
       Kallmann's syndrome
       Lorain-Levi short stature
       Necrosis of pituitary gland (postpartum)
       Panhypopituitarism
       Pituitary cachexia
       Pituitary insufficiency NOS
       Pituitary short stature
       Sheehan's syndrome
       Simmonds' disease
    E23.1 Drug-induced hypopituitarism
       Code first (T36-T50) to identify drug
    E23.2 Diabetes insipidus
       Excludes1: nephrogenic diabetes insipidus (N25.1)
    E23.3 Hypothalamic dysfunction, not elsewhere classified
       Excludes1: Prader-Willi syndrome (Q87.1)
          Russell-Silver syndrome (Q87.1)
    E23.6 Other disorders of pituitary gland
       Abscess of pituitary
       Adiposogenital dystrophy
    E23.7 Disorder of pituitary gland, unspecified ​

## E24 Cushing's syndromeE24 Cushing's syndrome

    Excludes1: congenital adrenal hyperplasia (E25.0)
    E24.0 Pituitary-dependent Cushing's disease
       Overproduction of pituitary ACTH
       Pituitary-dependent hypercorticalism
    E24.1 Nelson's syndrome
    E24.2 Drug-induced Cushing's syndrome
       Code first (T36-T50) to identify drug
    E24.3 Ectopic ACTH syndrome
    E24.4 Alcohol-induced pseudo-Cushing's syndrome
    E24.8 Other Cushing's syndrome
    E24.9 Cushing's syndrome, unspecified

## E25 Adrenogenital disordersE25 Adrenogenital disorders

    Includes: adrenogenital syndromes, virilizing or feminizing, whether acquired or due to adrenal hyperplasia consequent on inborn enzyme defects in hormone synthesis
    female:
       adrenal pseudohermaphroditism
       heterosexual precocious pseudopuberty
    male:
       isosexual precocious pseudopuberty
       macrogenitosomia praecox
       sexual precocity with adrenal hyperplasia
       virilization (female)
    Excludes1: indeterminate sex and pseudohermaphroditism (Q56)
       chromosomal abnormalities (Q90-Q99)
    E25.0 Congenital adrenogenital disorders associated with enzyme deficiency
       Congenital adrenal hyperplasia
       21-Hydroxylase deficiency
       Salt-losing congenital adrenal hyperplasia
    E25.8 Other adrenogenital disorders
       Idiopathic adrenogenital disorder
    E25.9 Adrenogenital disorder, unspecified
       Adrenogenital syndrome NOS

## E26 HyperaldosteronismE26 Hyperaldosteronism

    E26.0 Primary hyperaldosteronism
       E26.01 Conn's syndrome
          Code also adrenal adenoma (D35.0)
       E26.02 Glucocorticoid-remediable aldosteronism
          Familial aldosteronism type I
       E26.09 Other primary hyperaldosteronism
          Primary aldosteronism due to adrenal hyperplasia (bilateral)
    E26.1 Secondary hyperaldosteronism
    E26.8 Other hyperaldosteronism
       E26. ​81 Bartter?s syndrome
       E26.89 Other hyperaldosteronism
    E26.9 Hyperaldosteronism, unspecified
       Aldosteronism NOS
       Hyperaldosteronism NOS

## E27 Other disorders of adrenal glandE27 Other disorders of adrenal gland

    E27.0 Other adrenocortical overactivity
       Overproduction of ACTH, not associated with Cushing's disease
       Premature adrenarche
       Excludes1: Cushing's syndrome (E24.-)
    E27.1 Primary adrenocortical insufficiency
       Addison's disease
       Autoimmune adrenalitis
       Excludes1: Addison only phenotype adrenoleukodystrophy (E71.428)
          amyloidosis (E85.-)
          tuberculous Addison's disease (A18.7)
          Waterhouse-Friderichsen syndrome (A39.1)
    E27.2 Addisonian crisis
       Adrenal crisis
       Adrenocortical crisis
    E27.3 Drug-induced adrenocortical insufficiency
       Code first (T36-T50) to identify drug
    E27.4 Other and unspecified adrenocortical insufficiency
       Excludes1: adrenoleukodystrophy [Addison-Schilder] (E71.3-)
          Waterhouse-Friderichsen syndrome (A39.1)
       E27.40 Unspecified adrenocortical insufficiency
          Adrenocortical insufficiency NOS
          Hypoaldosteronism
       E27.49 Other adrenocortical insufficiency
          Adrenal hemorrhage
          Adrenal infarction
    E27.5 Adrenomedullary hyperfunction
       Adrenomedullary hyperplasia
       Catecholamine hypersecretion
    E27.8 Other specified disorders of adrenal gland
       Abnormality of cortisol-binding globulin
    E27.9 Disorder of adrenal gland, unspecified

## E28 Ovarian dysfunctionE28 Ovarian dysfunction

    Excludes1: isolated gonadotropin deficiency (E23.0)
       postprocedural ovarian failure (E89.4-)
    E28.0 Estrogen excess
    E28.1 Androgen excess
       Hypersecretion of ovarian androgens
    E28.2 Polycystic ovarian syndrome
       Sclerocystic ovary syndrome
       Stein​Leventhal syndrome
    E28.3 Primary ovarian failure
       Excludes1: pure gonadal dysgenesis (Q99.1)
          Turner's syndrome (Q96.-)
       E28.31 Premature menopause
          E28.310 Symptomatic premature menopause
             Symptoms such as flushing, sleeplessness, headache, lack of concentration, associated with premature menopause
          E28.319 Asymptomatic premature menopause
             Premature menopause NOS
       E28.39 Other primary ovarian failure
          Decreased estrogen
          Resistant ovary syndrome
    E28.8 Other ovarian dysfunction
       Ovarian hyperfunction NOS
       Excludes1: postprocedural ovarian failure (E89.4-)
    E28.9 Ovarian dysfunction, unspecified

## E29 Testicular dysfunctionE29 Testicular dysfunction

    Excludes1: androgen insensitivity syndrome (E34.5-)
       azoospermia or oligospermia NOS (N46.0-N46.1)
       isolated gonadotropin deficiency (E23.0)
       Klinefelter's syndrome (Q98.0-Q98.2, Q98.4)
    E29.0 Testicular hyperfunction
       Hypersecretion of testicular hormones
    E29.1 Testicular hypofunction
       Defective biosynthesis of testicular androgen NOS
       5-delta-Reductase deficiency (with male pseudohermaphroditism)
       Testicular hypogonadism NOS
       Excludes1: postprocedural testicular hypofunction (E89.5)
    E29.8 Other testicular dysfunction
    E29.9 Testicular dysfunction, unspecified

## E30 Disorders of puberty, not elsewhere classifiedE30 Disorders of puberty, not elsewhere classified

    E30.0 Delayed puberty
       Constitutional delay of puberty
       Delayed sexual development
    E30.1 Precocious puberty
       Precocious menstruation
       Excludes1: Albright (-McCune) (-Sternberg) syndrome (Q78.1)
          central precocious puberty (E22.8)
          congenital adrenal hyperplasia (E25.0)
          female heterosexual precocious pseudopuberty (E25.-)
          male isosexual precocious pseudopuberty (E25.-)
    E30.8 Other disorders of puberty
       Premature thelarche
    E30. ​9 Disorder of puberty, unspecified

## E31 Polyglandular dysfunctionE31 Polyglandular dysfunction

    Excludes1: ataxia telangiectasia [Louis-Bar] (G11.3)
       dystrophia myotonica [Steinert] (G71.11)
       pseudohypoparathyroidism (E20.1)
    E31.0 Autoimmune polyglandular failure
       Schmidt's syndrome
    E31.1 Polyglandular hyperfunction
       Excludes1: multiple endocrine adenomatosis (E31.2-)
          multiple endocrine neoplasia (E31.2-)
    E31.2 Multiple endocrine neoplasia [MEN] syndromes
       Multiple endocrine adenomatosis
       Code also any associated malignancies and other conditions associated with the syndromes
       E31.20 Multiple endocrine neoplasia [MEN] syndrome, unspecified
          Multiple endocrine adenomatosis NOS
          Multiple endocrine neoplasia [MEN] syndrome NOS
       E31.21 Multiple endocrine neoplasia [MEN] type I
          Wermer's syndrome
       E31.22 Multiple endocrine neoplasia [MEN] type IIA
          Sipple's syndrome
       E31.23 Multiple endocrine neoplasia [MEN] type IIB
    E31.8 Other polyglandular dysfunction
    E31.9 Polyglandular dysfunction, unspecified

## E32 Diseases of thymusE32 Diseases of thymus

    Excludes1: aplasia or hypoplasia of thymus with immunodeficiency (D82.1)
       myasthenia gravis (G70.0)
    E32.0 Persistent hyperplasia of thymus
       Hypertrophy of thymus
    E32.1 Abscess of thymus
    E32.8 Other diseases of thymus
       Excludes1: aplasia or hypoplasia with immunodeficiency (D82.1)
          thymoma (D15.0)
    E32.9 Disease of thymus, unspecified

## E34 Other endocrine disordersE34 Other endocrine disorders

    Excludes1: pseudohypoparathyroidism (E20.1)
    E34.0 Carcinoid syndrome
       Note: May be used as an additional code to identify functional activity associated with a carcinoid tumor.
    E34.1 Other hypersecretion of intestinal hormones
    E34.2 Ectopic hormone secretion, not elsewhere classified
       Excludes1: ectopic ACTH syndrome (E24.3)
    E34.3 Short stature due to endocrine disorder
       Constitutional short stature
       Laron​type short stature
       Excludes1: achondroplastic short stature (Q77.4)
          hypochondroplastic short stature (Q77.4)
          nutritional short stature (E45)
          pituitary short stature (E23.0)
          progeria (E34.8)
          renal short stature (N25.0)
          Russell-Silver syndrome (Q87.1)
          short-limbed stature with immunodeficiency (D82.2)
          short stature in specific dysmorphic syndromes - code to syndrome - see Alphabetical Index
          short stature NOS (R62.52)
    E34.4 Constitutional tall stature
       Constitutional gigantism
    E34.5 Androgen insensitivity syndrome
       E34.50 Androgen insensitivity syndrome, unspecified
          Androgen insensitivity NOS
       E34.51 Complete androgen insensitivity syndrome
          Complete androgen insensitivity
          de Quervain syndrome
          Goldberg-Maxwell syndrome
       E34.52 Partial androgen insensitivity syndrome
          Partial androgen insensitivity
          Reifenstein syndrome
    E34.8 Other specified endocrine disorders
       Pineal gland dysfunction
       Progeria
       Excludes2: pseudohypoparathyroidism (E20.1)
    E34.9 Endocrine disorder, unspecified
       Endocrine disturbance NOS
       Hormone disturbance NOS

## E35 Disorders of endocrine glands in diseases classified elsewhereE35 Disorders of endocrine glands in diseases classified elsewhere

    Code first underlying disease, such as:
       late congenital syphilis of thymus gland [Dubois disease] (A50.5)
       tuberculous calcification of adrenal gland (B90.8)
    Excludes1: Echinococcus granulosus infection of thyroid gland (B67.3)
       meningococcal hemorrhagic adrenalitis (A39.1)
       syphilis of endocrine gland (A52.79)
       tuberculosis of:
       adrenal gland, except calcification (A18.7)
       endocrine gland NEC (A18.82)
       thyroid gland (A18.81)
       Waterhouse-Friderichsen syndrome (A39.1)

# E36 Intraoperative complications of endocrine systemE36 Intraoperative complications of endocrine system

    Excludes2: ​postprocedural endocrine and metabolic complications and disorders, not elsewhere classified (E89.-)
    E36.0 Intraoperative hemorrhage and hematoma of an endocrine system organ or structure complicating a procedure
       Excludes1: intraoperative hemorrhage and hematoma of an endocrine system organ or structure due to accidental puncture or laceration during a procedure (E36.1-)
       E36.01 Intraoperative hemorrhage and hematoma of an endocrine system organ or structure complicating an endocrine system procedure
       E36.02 Intraoperative hemorrhage and hematoma of an endocrine system organ or structure complicating other procedure
    E36.1 Accidental puncture and laceration of an endocrine system organ or structure during a procedure
       E36.11 Accidental puncture and laceration of an endocrine system organ or structure during an endocrine system procedure
       E36.12 Accidental puncture and laceration of an endocrine system organ or structure during other procedure
    E36.8 Other intraoperative complications of endocrine system
       Use additional code, if applicable, to further specify disorder

# Malnutrition (E40-E46)Malnutrition (E40-E46)

    Excludes1: intestinal malabsorption (K90.-)
       sequelae of protein-calorie malnutrition (E64.0)
    Excludes2: nutritional anemias (D50-D53)
       starvation (T73.0)

## E40 KwashiorkorE40 Kwashiorkor

    Includes: severe malnutrition with nutritional edema with dyspigmentation of skin and hair
    Excludes1: marasmic kwashiorkor (E42)

## E41 Nutritional marasmusE41 Nutritional marasmus

    Includes: severe malnutrition with marasmus
    Excludes1: marasmic kwashiorkor (E42)

## E42 Marasmic kwashiorkorE42 Marasmic kwashiorkor

    Includes: severe protein-calorie malnutrition with signs of both kwashiorkor and marasmus
       intermediate form severe protein-calorie malnutrition

## E43 Unspecified severe protein-calorie malnutritionE43 Unspecified severe protein-calorie malnutrition

    Includes: starvation edema

## E44 ​Protein-calorie malnutrition of moderate and mild degree

    E44.0 Moderate protein-calorie malnutrition
    E44.1 Mild protein-calorie malnutrition

## E45 Retarded development following protein-calorie malnutritionE45 Retarded development following protein-calorie malnutrition

    Includes: nutritional short stature
       nutritional stunting
       physical retardation due to malnutrition

## E46 Unspecified protein-calorie malnutritionE46 Unspecified protein-calorie malnutrition

    Includes: malnutrition NOS
       protein-calorie imbalance NOS
    Excludes1: nutritional deficiency NOS (E63.9)

# Other nutritional deficiencies (E50-E64)Other nutritional deficiencies (E50-E64)

    Excludes2: nutritional anemias (D50-D53)

## E50 Vitamin A deficiencyE50 Vitamin A deficiency

    Excludes1: sequelae of vitamin A deficiency (E64.1)
    E50.0 Vitamin A deficiency with conjunctival xerosis
    E50.1 Vitamin A deficiency with Bitot's spot and conjunctival xerosis
       Bitot's spot in the young child
    E50.2 Vitamin A deficiency with corneal xerosis
    E50.3 Vitamin A deficiency with corneal ulceration and xerosis
    E50.4 Vitamin A deficiency with keratomalacia
    E50.5 Vitamin A deficiency with night blindness
    E50.6 Vitamin A deficiency with xerophthalmic scars of cornea
    E50.7 Other ocular manifestations of vitamin A deficiency
       Xerophthalmia NOS
    E50.8 Other manifestations of vitamin A deficiency
       Follicular keratosis
       Xeroderma
    E50.9 Vitamin A deficiency, unspecified
       Hypovitaminosis A NOS

## E51 Thiamine deficiencyE51 Thiamine deficiency

    Excludes1: sequelae of thiamine deficiency (E64.8)
    E51.1 Beriberi
       E51.11 Dry beriberi
          Beriberi NOS
          Beriberi with polyneuropathy
       E51.12 Wet beriberi
          Beriberi with cardiovascular manifestations
          Cardiovascular beriberi
          Shoshin disease
    E51. ​2 Wernicke's encephalopathy
    E51.8 Other manifestations of thiamine deficiency
    E51.9 Thiamine deficiency, unspecified

## E52 Niacin deficiency [pellagra]E52 Niacin deficiency [pellagra]

    Includes: niacin (-tryptophan) deficiency
       nicotinamide deficiency
       pellagra (alcoholic)
    Excludes1: sequelae of niacin deficiency (E64.8)

## E53 Deficiency of other B group vitaminsE53 Deficiency of other B group vitamins

    Excludes1: sequelae of vitamin B deficiency (E64.8)
    E53.0 Riboflavin deficiency
       Ariboflavinosis
       Vitamin B2 deficiency
    E53.1 Pyridoxine deficiency
       Vitamin B6 deficiency
       Excludes1: pyridoxine-responsive sideroblastic anemia (D64.3)
    E53.8 Deficiency of other specified B group vitamins
       Biotin deficiency
       Cyanocobalamin deficiency
       Folate deficiency
       Folic acid deficiency
       Pantothenic acid deficiency
       Vitamin B12 deficiency
       Excludes1: folate deficiency anemia (D52.-)
          vitamin B12 deficiency anemia (D51.-)
    E53.9 Vitamin B deficiency, unspecified

## E54 Ascorbic acid deficiencyE54 Ascorbic acid deficiency

    Includes: deficiency of vitamin C
       scurvy
    Excludes1: scorbutic anemia (D53.2)
       sequelae of vitamin C deficiency (E64.2)

## E55 Vitamin D deficiencyE55 Vitamin D deficiency

    Excludes1: adult osteomalacia (M83.-)
       osteoporosis (M80-)
       sequelae of rickets (E64.3)
    E55.0 Rickets, active
       Infantile Osteomalacia
       Juvenile Osteomalacia
       Excludes1: celiac rickets (K90.0)
          Crohn's rickets (K50.-)
          hereditary vitamin D-dependent rickets (E83.32)
          inactive ​rickets (E64.3)
          renal rickets (N25.0)
          sequelae of rickets (E64.3)
          vitamin D-resistant rickets (E83.31)
    E55.9 Vitamin D deficiency, unspecified
       Avitaminosis D

## E56 Other vitamin deficienciesE56 Other vitamin deficiencies

    Excludes1: sequelae of other vitamin deficiencies (E64.8)
    E56.0 Deficiency of vitamin E
    E56.1 Deficiency of vitamin K
       Excludes1: deficiency of coagulation factor due to vitamin K deficiency (D68.4)
          vitamin K deficiency of newborn (P53)
    E56.8 Deficiency of other vitamins
    E56.9 Vitamin deficiency, unspecified

## E58 Dietary calcium deficiencyE58 Dietary calcium deficiency

    Excludes1: disorders of calcium metabolism (E83.5)
       sequelae of calcium deficiency (E64.8)

## E59 Dietary selenium deficiencyE59 Dietary selenium deficiency

    Includes: Keshan disease
    Excludes1: sequelae of selenium deficiency (E64.8)

## E61 Deficiency of other nutrient elementsE61 Deficiency of other nutrient elements

    Excludes1: disorders of mineral metabolism (E83.-)
       iodine deficiency related thyroid disorders (E00-E02)
       sequelae of malnutrition and other nutritional deficiencies (E64.-)
    E61.0 Copper deficiency
    E61.1 Iron deficiency
       Excludes1: iron deficiency anemia (D50.-)
    E61.2 Magnesium deficiency
    E61.3 Manganese deficiency
    E61.4 Chromium deficiency
    E61.5 Molybdenum deficiency
    E61.6 Vanadium deficiency
    E61.7 Deficiency of multiple nutrient elements
    E61.8 Deficiency of other specified nutrient elements
    E61.9 Deficiency of nutrient element, unspecified

## E63 Other nutritional deficienciesE63 Other nutritional deficiencies

    Excludes1: dehydration (E86.0)
       failure to thrive, adult (R62.7)
       failure to thrive, child (R62.51)
       feeding problems in newborn (P92.-)
       sequelae ​of malnutrition and other nutritional deficiencies (E64.-)
    E63.0 Essential fatty acid [EFA] deficiency
    E63.1 Imbalance of constituents of food intake
    E63.8 Other specified nutritional deficiencies
    E63.9 Nutritional deficiency, unspecified

## E64 Sequelae of malnutrition and other nutritional deficienciesE64 Sequelae of malnutrition and other nutritional deficiencies

    This category is to be used to indicate conditions in categories E43, E44, E46, E50-E63 as the cause of sequelae, which are themselves classified elsewhere. The "sequelae" include conditions specified as such; they also include the late effects of diseases classifiable to the above categories if the disease itself is no longer present
    Code first condition resulting from (sequela) of malnutrition and other nutritional deficiencies
    E64.0 Sequelae of protein-calorie malnutrition
       Excludes2: retarded development following protein-calorie malnutrition (E45)
    E64.1 Sequelae of vitamin A deficiency
    E64.2 Sequelae of vitamin C deficiency
    E64.3 Sequelae of rickets
    E64.8 Sequelae of other nutritional deficiencies
    E64.9 Sequelae of unspecified nutritional deficiency

# Overweight, obesity and other hyperalimentation (E65-E68)Overweight, obesity and other hyperalimentation (E65-E68)
## E65 Localized adiposityE65 Localized adiposity

    Fat pad

## E66 Overweight and obesityE66 Overweight and obesity

    Code first: obesity complicating pregnancy, childbirth and the puerperium, if applicable (O99.21-)
    Use additional code to identify body mass index (BMI), if known (Z68.-)
    Excludes1: adiposogenital dystrophy (E23.6)
       lipomatosis NOS (E88.2)
       lipomatosis dolorosa [Dercum] (E88.2)
       Prader-Willi syndrome (Q87.1)
    E66.0 Obesity due to excess calories
       E66.01 Morbid (severe) obesity due to excess calories
          Excludes1: morbid (severe) obesity with alveolar hypoventilation (E66.2)
       E66.09 Other obesity due to excess calories
    E66.1 Drug-induced obesity
       Code first (T36-T50) to identify drug
    E66. ​2 Morbid (severe) obesity with alveolar hypoventilation
       Pickwickian syndrome
    E66.3 Overweight
    E66.8 Other obesity
    E66.9 Obesity, unspecified
       Obesity NOS

## E67 Other hyperalimentationE67 Other hyperalimentation

    Excludes1: hyperalimentation NOS (R63.2)
       sequelae of hyperalimentation (E68)
    E67.0 Hypervitaminosis A
    E67.1 Hypercarotinemia
    E67.2 Megavitamin-B6 syndrome
    E67.3 Hypervitaminosis D
    E67.8 Other specified hyperalimentation

## E68 Sequelae of hyperalimentationE68 Sequelae of hyperalimentation

    Code first condition resulting from (sequela) of hyperalimentation

# Metabolic disorders (E70-E90)Metabolic disorders (E70-E90)

    Excludes1: androgen insensitivity syndrome (E34.5-)
       congenital adrenal hyperplasia (E25.0)
       Ehlers-Danlos syndrome (Q79.6)
       hemolytic anemias attributable to enzyme disorders (D55.-)
       Marfan's syndrome (Q87.4)
       5-alpha-reductase deficiency (E29.1)

## E70 Disorders of aromatic amino-acid metabolismE70 Disorders of aromatic amino-acid metabolism

    E70.0 Classical phenylketonuria
    E70.1 Other hyperphenylalaninemias
    E70.2 Disorders of tyrosine metabolism
       Excludes1: transitory tyrosinemia of newborn (P74.5)
       E70.20 Disorder of tyrosine metabolism, unspecified
       E70.21 Tyrosinemia
          Hypertyrosinemia
       E70.29 Other disorders of tyrosine metabolism
          Alkaptonuria
          Ochronosis
    E70.3 Albinism
       E70.30 Albinism, unspecified
       E70.31 Ocular albinism
          E70.310 X-linked ocular albinism
          E70.311 Autosomal recessive ocular albinism
          E70.318 Other ocular albinism
          E70.319 Ocular albinism, unspecified
       E70. ​32 Oculocutaneous albinism
          Excludes1: Chediak-Higashi syndrome (E70.330)
             Hermansky-Pudlak syndrome (E70.331)
          E70.320 Tyrosinase negative oculocutaneous albinism
             Albinism I
             Oculocutaneous albinism ty-neg
          E70.321 Tyrosinase positive oculocutaneous albinism
             Albinism II
             Oculocutaneous albinism ty-pos
          E70.328 Other oculocutaneous albinism
             Cross syndrome
          E70.329 Oculocutaneous albinism, unspecified
       E70.33 Albinism with hematologic abnormality
          E70.330 Chediak-Higashi syndrome
          E70.331 Hermansky-Pudlak syndrome
          E70.338 Other albinism with hematologic abnormality
          E70.339 Albinism with hematologic abnormality, unspecified
       E70.39 Other specified albinism
          Piebaldism
    E70.4 Disorders of histidine metabolism
       E70.40 Disorders of histidine metabolism, unspecified
       E70.41 Histidinemia
       E70.49 Other disorders of histidine metabolism
    E70.5 Disorders of tryptophan metabolism
    E70.8 Other disorders of aromatic amino-acid metabolism
    E70.9 Disorder of aromatic amino-acid metabolism, unspecified

## E71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolismE71 Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism

    E71.0 Maple-syrup-urine disease
    E71.1 Other disorders of branched-chain amino-acid metabolism
       E71.11 Branched-chain organic acidurias
          E71.110 Isovaleric acidemia
          E71.111 3-methylglutaconic aciduria
          E71.118 Other branched-chain organic acidurias
       E71.12 Disorders of propionate metabolism
          E71.120 Methylmalonic acidemia
          E71.121 Propionic acidemia
          E71.128 Other disorders of propionate metabolism
       E71.19 Other disorders of branched-chain amino-acid metabolism
          Hyperleucine-isoleucinemia
          Hypervalinemia
    ​E71.2 Disorder of branched-chain amino-acid metabolism, unspecified
    E71.3 Disorders of fatty-acid metabolism
       Excludes1: peroxisomal disorders (E71.5)
          Refsum's disease (G60.1)
          Schilder's disease (G37.0)
       Excludes2: carnitine deficiency due to inborn error of metabolism (E71.42)
       E71.30 Disorder of fatty-acid metabolism, unspecified
       E71.31 Disorders of fatty-acid oxidation
          E71.310 Long chain/very long chain acyl CoA dehydrogenase deficiency
             LCAD
             VLCAD
          E71.311 Medium chain acyl CoA dehydrogenase deficiency
             MCAD
          E71.312 Short chain acyl CoA dehydrogenase deficiency
             SCAD
          E71.313 Glutaric aciduria type II
             Glutaric aciduria type II A
             Glutaric aciduria type II B
             Glutaric aciduria type II C
             Excludes1: glutaric aciduria (type 1) NOS (E72.3)
          E71.314 Muscle carnitine palmitoyltransferase deficiency
          E71.318 Other disorders of fatty-acid oxidation
       E71.32 Disorders of ketone metabolism
       E71.39 Other disorders of fatty-acid metabolism
    E71.4 Disorders of carnitine metabolism
       Excludes1: Muscle carnitine palmitoyltransferase deficiency (E71.314)
       E71.40 Disorder of carnitine metabolism, unspecified
       E71.41 Primary carnitine deficiency
       E71.42 Carnitine deficiency due to inborn errors of metabolism
          Code also associated inborn error or metabolism
       E71.43 Iatrogenic carnitine deficiency
          Carnitine deficiency due to:
          hemodialysis
          Valproic acid therapy
       E71.44 Other secondary carnitine deficiency
          E71.440 Ruvalcaba-Myhre-Smith syndrome
          E71.448 Other secondary carnitine deficiency
    E71.5 Peroxisomal disorders
       Excludes1: Schilder?s disease (G37.0)
       E71.50 Peroxisomal disorder, unspecified
       E71. ​51 Disorders of peroxisome biogenesis
          Group 1 peroxisomal disorders
          Excludes1: Refsum's disease (G60.1)
          E71.510 Zellweger syndrome
          E71.511 Neonatal adrenoleukodystrophy
             Excludes1: X-linked adrenoleukodystrophy (E71.42-)
          E71.518 Other disorders of peroxisome biogenesis
       E71.52 X-linked adrenoleukodystrophy
          E71.520 Childhood cerebral X-linked adrenoleukodystrophy
          E71.521 Adolescent X-linked adrenoleukodystrophy
          E71.522 Adrenomyeloneuropathy
          E71.528 Other X-linked adrenoleukodystrophy
             Addison only phenotype adrenoleukodystrophy
             Addison-Schilder adrenoleukodystrophy
          E71.529 X-linked adrenoleukodystrophy, unspecified
       E71.53 Other group 2 peroxisomal disorders
       E71.54 Other peroxisomal disorders
          E71.540 Rhizomelic chondrodysplasia punctata
             Excludes1: chondrodysplasia punctata NOS (Q77.3)
          E71.541 Zellweger-like syndrome
          E71.542 Other group 3 peroxisomal disorders
          E71.548 Other peroxisomal disorders

## E72 Other disorders of amino-acid metabolismE72 Other disorders of amino-acid metabolism

    Excludes1: disorders of:
       aromatic amino-acid metabolism (E70.-)
       branched-chain amino-acid metabolism (E71.0-E71.2)
       fatty-acid metabolism (E71.3)
       purine and pyrimidine metabolism (E79.-)
       gout ( M1a-, M10.-)
    E72.0 Disorders of amino-acid transport
       Excludes1: disorders of tryptophan metabolism (E70.5)
       E72.00 Disorders of amino-acid transport, unspecified
       E72.01 Cystinuria
       E72.02 Hartnup's disease
       E72.03 Lowe's syndrome
          Use additional code for associated glaucoma (H42)
       E72.04 Cystinosis
          Fanconi (-de Toni) (-Debr?) syndrome with cystinosis
          Excludes1: Fanconi (-de Toni) (-Debr?) syndrome without cystinosis (E72.09)
       E72.09 Other disorders of amino-acid transport
          Fanconi (-de Toni) (-Debr?) syndrome, unspecified
    E72. ​1 Disorders of sulfur-bearing amino-acid metabolism
       Excludes1: cystinosis (E72.04)
          cystinuria (E72.01)
          transcobalamin II deficiency (D51.2)
       E72.10 Disorders of sulfur-bearing amino-acid metabolism, unspecified
       E72.11 Homocystinuria
          Cystathionine synthase deficiency
       E72.12 Methylenetetrahydrofolate reductase deficiency
       E72.19 Other disorders of sulfur-bearing amino-acid metabolism
          Cystathioninuria
          Methioninemia
          Sulfite oxidase deficiency
    E72.2 Disorders of urea cycle metabolism
       Excludes1: disorders of ornithine metabolism (E72.4)
       E72.20 Disorder of urea cycle metabolism, unspecified
          Hyperammonemia
          Excludes1: hyperammonemia-hyperornithinemia-homocitrullinemia syndrome E72.4
             transient hyperammonemia of newborn (P74.6)
       E72.21 Argininemia
       E72.22 Arginosuccinic aciduria
       E72.23 Citrullinemia
       E72.29 Other disorders of urea cycle metabolism
    E72.3 Disorders of lysine and hydroxylysine metabolism
       Glutaric aciduria NOS
       Glutaric aciduria (type I)
       Hydroxylysinemia
       Hyperlysinemia
       Excludes1: glutaric aciduria type II (E71.313)
          Refsum's disease (G60.1)
          Zellweger syndrome (E71.510)
    E72.4 Disorders of ornithine metabolism
       Hyperammonemia-Hyperornithinemia-Homocitrullinemia syndrome
       Ornithinemia (types I, II)
       Ornithine transcarbamylase deficiency
       Excludes1: hereditary choroidal dystrophy (H31.2-)
    E72.5 Disorders of glycine metabolism
       E72.50 Disorder of glycine metabolism, unspecified
       E72.51 Non-ketotic hyperglycinemia
       E72.52 Trimethylaminuria
       E72.53 Hyperoxaluria
          Oxalosis
          Oxaluria
       E72. ​59 Other disorders of glycine metabolism
          D-glycericacidemia
          Hyperhydroxyprolinemia
          Hyperprolinemia (types I, II)
          Sarcosinemia
    E72.8 Other specified disorders of amino-acid metabolism
       Disorders of beta-amino-acid metabolism
       Disorders of gamma-glutamyl cycle
    E72.9 Disorder of amino-acid metabolism, unspecified

## E73 Lactose intoleranceE73 Lactose intolerance

    E73.0 Congenital lactase deficiency
    E73.1 Secondary lactase deficiency
    E73.8 Other lactose intolerance
    E73.9 Lactose intolerance, unspecified

## E74 Other disorders of carbohydrate metabolismE74 Other disorders of carbohydrate metabolism

    Excludes1: diabetes mellitus (E09-E13)
       hypoglycemia NOS (E16.2)
       increased secretion of glucagon (E16.3)
       mucopolysaccharidosis (E76.0--E76.3)
    E74.0 Glycogen storage disease
       E74.00 Glycogen storage disease, unspecified
       E74.01 von Gierke disease
          Type I glycogen storage disease
       E74.02 Pompe disease
          Cardiac glycogenosis
          Type II glycogen storage disease
       E74.03 Cori disease
          Forbes disease
          Type III glycogen storage disease
       E74.04 McArdle disease
          Type V glycogen storage disease
       E74.09 Other glycogen storage disease
          Andersen disease
          Hers disease
          Tauri disease
          Glycogen storage disease, types 0, IV, VI-XI
          Liver phosphorylase deficiency
          Muscle phosphofructokinase deficiency
    E74.1 Disorders of fructose metabolism
       Excludes1: muscle phosphofructokinase deficiency (E74.09)
       E74.10 Disorder of fructose metabolism, unspecified
       E74.11 Essential fructosuria
          Fructokinase deficiency
       E74.12 Hereditary fructose intolerance
          Fructosemia
       E74. ​19 Other disorders of fructose metabolism
          Fructose-1, 6-diphosphatase deficiency
    E74.2 Disorders of galactose metabolism
       E74.20 Disorders of galactose metabolism, unspecified
       E74.21 Galactosemia
       E74.29 Other disorders of galactose metabolism
          Galactokinase deficiency
    E74.3 Other disorders of intestinal carbohydrate absorption
       Excludes2: lactose intolerance (E73.-)
       E74.31 Sucrase-isomaltase deficiency
       E74.39 Other disorders of intestinal carbohydrate absorption
          Disorder of intestinal carbohydrate absorption NOS
          Glucose-galactose malabsorption
          Sucrase deficiency
    E74.4 Disorders of pyruvate metabolism and gluconeogenesis
       Deficiency of phosphoenolpyruvate carboxykinase
       Deficiency of pyruvate carboxylase
       Deficiency of pyruvate dehydrogenase
       Excludes1: disorders of pyruvate metabolism and gluconeogenesis with anemia (D55.-)
          Leigh?s syndrome (G31.82)
    E74.8 Other specified disorders of carbohydrate metabolism
       Essential pentosuria
       Renal glycosuria
    E74.9 Disorder of carbohydrate metabolism, unspecified

## E75 Disorders of sphingolipid metabolism and other lipid storage disordersE75 Disorders of sphingolipid metabolism and other lipid storage disorders

    Excludes1: mucolipidosis, types I-III (E77.0-E77.1)
       Refsum's disease (G60.1)
    E75.0 GM2 gangliosidosis
       E75.00 GM2 gangliosidosis, unspecified
       E75.01 Sandhoff disease
       E75.02 Tay-Sachs disease
       E75.09 Other GM2 gangliosidosis
          Adult GM2 gangliosidosis
          Juvenile GM2 gangliosidosis
    E75.1 Other and unspecified gangliosidosis
       E75.10 Unspecified gangliosidosis
          Gangliosidosis NOS
       E75.11 Mucolipidosis IV
       E75.19 Other gangliosidosis
          GM1 gangliosidosis
          GM3 ​gangliosidosis
    E75.2 Other sphingolipidosis
       Excludes1: adrenoleukodystrophy [Addison-Schilder] (E71.30)
       E75.21 Fabry (-Anderson) disease
       E75.22 Gaucher disease
       E75.23 Krabbe disease
       E75.24 Niemann-Pick disease
          E75.240 Niemann-Pick disease type A
          E75.241 Niemann-Pick disease type B
          E75.242 Niemann-Pick disease type C
          E75.243 Niemann-Pick disease type D
          E75.248 Other Niemann-Pick disease
          E75.249 Niemann-Pick disease, unspecified
       E75.25 Metachromatic leukodystrophy
       E75.29 Other sphingolipidosis
          Farber's syndrome
          Sulfatase deficiency
          Sulfatide lipidosis
    E75.3 Sphingolipidosis, unspecified
    E75.4 Neuronal ceroid lipofuscinosis
       Batten disease
       Bielschowsky-Jansky disease
       Kufs disease
       Spielmeyer-Vogt disease
    E75.5 Other lipid storage disorders
       Cerebrotendinous cholesterosis [van Bogaert-Scherer-Epstein]
       Wolman's disease
    E75.6 Lipid storage disorder, unspecified

## E76 Disorders of glycosaminoglycan metabolismE76 Disorders of glycosaminoglycan metabolism

    E76.0 Mucopolysaccharidosis, type I
       E76.01 Hurler?s syndrome
       E76.02 Hurler-Scheie syndrome
       E76.03 Scheie?s syndrome
    E76.1 Mucopolysaccharidosis, type II
       Hunter's syndrome
    E76.2 Other mucopolysaccharidoses
       E76.21 Morquio mucopolysaccharidoses
          E76.210 Morquio A mucopolysaccharidoses
             Classic Morquio syndrome
             Morquio syndrome A
             Mucopolysaccharidosis, type IVA
          E76.211 Morquio B mucopolysaccharidoses
             Morquio-like mucopolysaccharidoses
             Morquio-like syndrome
             Morquio syndrome B
             Mucopolysaccharidosis, ​type IVB
          E76.219 Morquio mucopolysaccharidoses, unspecified
             Morquio syndrome
             Mucopolysaccharidosis, type IV
       E76.22 Sanfilippo mucopolysaccharidoses
             Mucopolysaccharidosis, type III (A) (B) (C) (D)
             Sanfilippo A syndrome
             Sanfilippo B syndrome
             Sanfilippo C syndrome
             Sanfilippo D syndrome
       E76.29 Other mucopolysaccharidoses
             beta-Glucuronidase deficiency
             Maroteaux-Lamy (mild) (severe) syndrome
             Mucopolysaccharidosis, types VI, VII
    E76.3 Mucopolysaccharidosis, unspecified
    E76.8 Other disorders of glucosaminoglycan metabolism
    E76.9 Glucosaminoglycan metabolism disorder, unspecified

## E77 Disorders of glycoprotein metabolismE77 Disorders of glycoprotein metabolism

    E77.0 Defects in post-translational modification of lysosomal enzymes
       Mucolipidosis II [I-cell disease]
       Mucolipidosis III [pseudo-Hurler polydystrophy]
    E77.1 Defects in glycoprotein degradation
       Aspartylglucosaminuria
       Fucosidosis
       Mannosidosis
       Sialidosis [mucolipidosis I]
    E77.8 Other disorders of glycoprotein metabolism
    E77.9 Disorder of glycoprotein metabolism, unspecified
    E78 Disorders of lipoprotein metabolism and other lipidemias
       Excludes1: sphingolipidosis (E75.0-E75.3)

## E78.0 Pure hypercholesterolemiaE78.0 Pure hypercholesterolemia

    Familial hypercholesterolemia
    Fredrickson's hyperlipoproteinemia, type IIa
    Hyperbetalipoproteinemia
    Hyperlipidemia, Group A
    Low-density-lipoprotein-type [LDL] hyperlipoproteinemia
    E78.1 Pure hyperglyceridemia
       Elevated fasting triglycerides
       Endogenous hyperglyceridemia
       Fredrickson's hyperlipoproteinemia, type IV
       Hyperlipidemia, group B
       Hyperprebetalipoproteinemia
       Very-low-density-lipoprotein-type [VLDL] hyperlipoproteinemia
    E78. ​2 Mixed hyperlipidemia
       Broad- or floating-betalipoproteinemia
       Combined hyperlipidemia NOS
       Elevated cholesterol with elevated triglycerides NEC
       Fredrickson's hyperlipoproteinemia, type IIb or III
       Hyperbetalipoproteinemia with prebetalipoproteinemia
       Hypercholesteremia with endogenous hyperglyceridemia
       Hyperlipidemia, group C
       Tubo-eruptive xanthoma
       Xanthoma tuberosum
       Excludes1: cerebrotendinous cholesterosis [van Bogaert-Scherer- Epstein] (E75.5)
          familial combined hyperlipidemia (E78.4)
    E78.3 Hyperchylomicronemia
       Chylomicron retention disease
       Fredrickson's hyperlipoproteinemia, type I or V
       Hyperlipidemia, group D
       Mixed hyperglyceridemia
    E78.4 Other hyperlipidemia
       Familial combined hyperlipidemia
    E78.5 Hyperlipidemia, unspecified
    E78.6 Lipoprotein deficiency
       Abetalipoproteinemia
       Depressed HDL cholesterol
       High-density lipoprotein deficiency
       Hypoalphalipoproteinemia
       Hypobetalipoproteinemia (familial)
       Lecithin cholesterol acyltransferase deficiency
       Tangier disease
    E78.7 Disorders of bile acid and cholesterol metabolism
       Excludes1: Niemann-Pick disease type C (E75.242)
       E78.70 Disorder of bile acid and cholesterol metabolism, unspecified
       E78.71 Barth syndrome
       E78.72 Smith-Lemli-Opitz syndrome
       E78.79 Other disorders of bile acid and cholesterol metabolism
    E78.8 Other disorders of lipoprotein metabolism
       E78.81 Lipoid dermatoarthritis
       E78.89 Other lipoprotein metabolism disorders
    E78.9 Disorder of lipoprotein metabolism, unspecified

## E79 Disorders of purine and pyrimidine metabolismE79 Disorders of purine and pyrimidine metabolism

    Excludes1: Ataxia-telangiectasia (Q87.1)
       Bloom's syndrome (Q82.8)
       Cockayne's syndrome (Q87.1)
       calculus of kidney (N20.0)
       combined ​immunodeficiency disorders (D81.-)
       Fanconi's anemia (D61.09)
       gout ( M1a-, M10.-)
       orotaciduric anemia (D53.0)
       progeria (E34.8)
       Werner's syndrome (E34.8)
       xeroderma pigmentosum (Q82.1)
    E79.0 Hyperuricemia without signs of inflammatory arthritis and tophaceous disease
       Asymptomatic hyperuricemia
    E79.1 Lesch-Nyhan syndrome
       HGPRT deficiency
    E79.2 Myoadenylate deaminase deficiency
    E79.8 Other disorders of purine and pyrimidine metabolism
       Hereditary xanthinuria
    E79.9 Disorder of purine and pyrimidine metabolism, unspecified

## E80 Disorders of porphyrin and bilirubin metabolismE80 Disorders of porphyrin and bilirubin metabolism

    Includes: defects of catalase and peroxidase
    E80.0 Hereditary erythropoietic porphyria
       Congenital erythropoietic porphyria
       Erythropoietic protoporphyria
    E80.1 Porphyria cutanea tarda
    E80.2 Other and unspecified porphyria
       E80.20 Unspecified porphyria
          Porphyria NOS
       E80.21 Acute intermittent (hepatic) porphyria
       E80.29 Other porphyria
          Hereditary coproporphyria
    E80.3 Defects of catalase and peroxidase
       Acatalasia [Takahara]
    E80.4 Gilbert's syndrome
    E80.5 Crigler-Najjar syndrome
    E80.6 Other disorders of bilirubin metabolism
       Dubin-Johnson syndrome
       Rotor's syndrome
    E80.7 Disorder of bilirubin metabolism, unspecified

## E83 Disorders of mineral metabolismE83 Disorders of mineral metabolism

    Excludes1: dietary mineral deficiency (E58-E61)
       parathyroid disorders (E20-E21)
       vitamin D deficiency (E55.-)
    E83.0 Disorders of copper metabolism
       E83.00 Disorder of copper metabolism, unspecified
       E83.01 Wilson's disease
          Code also associated Kayser Fleischer ring (H18.04-)
       E83.09 Other disorders of copper metabolism
          Menkes' ( ​kinky hair) (steely hair) disease
    E83.1 Disorders of iron metabolism
       Excludes1: iron deficiency anemia (D50.-)
          sideroblastic anemia (D64.0-D64.3)
       E83.10 Disorder of iron metabolism, unspecified
       E83.11 Hemochromatosis
       E83.19 Other disorders of iron metabolism
    E83.2 Disorders of zinc metabolism
       Acrodermatitis enteropathica
    E83.3 Disorders of phosphorus metabolism and phosphatases
       Excludes1: adult osteomalacia (M83.-)
          osteoporosis (M80-)
       E83.30 Disorder of phosphorus metabolism, unspecified
       E83.31 Familial hypophosphatemia
          Vitamin D-resistant osteomalacia
          Vitamin D-resistant rickets
          Excludes1: vitamin D-deficiency rickets (E55.0)
       E83.32 Hereditary vitamin D-dependent rickets (type 1) (type 2)
          25-hydroxyvitamin D 1-alpha-hydroxylase deficiency
          Pseudovitamin D deficiency
          Vitamin D receptor defect
       E83.39 Other disorders of phosphorus metabolism
          Acid phosphatase deficiency
          Hypophosphatasia
    E83.4 Disorders of magnesium metabolism
       E83.40 Disorders of magnesium metabolism, unspecified
       E83.41 Hypermagnesemia
       E83.42 Hypomagnesemia
       E83.49 Other disorders of magnesium metabolism
    E83.5 Disorders of calcium metabolism
          Excludes1: chondrocalcinosis (M11.1-M11.2)
          hungry bone syndrome (E83.81)
          hyperparathyroidism (E21.0-E21.3)
       E83.50 Unspecified disorder of calcium metabolism
       E83.51 Hypocalcemia
       E83.52 Hypercalcemia
          Familial hypocalciuric hypercalcemia
       E83.59 Other disorders of calcium metabolism
          Idiopathic hypercalciuria
    E83.8 Other disorders of mineral metabolism
       E83.81 Hungry bone syndrome
       E83.89 Other disorders of mineral metabolism
    E83.9 Disorder of mineral metabolism, unspecified

## E84 Cystic fibrosisE84 Cystic fibrosis

    Includes: mucoviscidosis
    E84. ​0 Cystic fibrosis with pulmonary manifestations
       Use additional code to identify any infectious organism present, such as:
       Pseudomonas (B96.5)
    E84.1 Cystic fibrosis with intestinal manifestations
       E84.11 Meconium ileus in cystic fibrosis
          Excludes1: meconium ileus not due to cystic fibrosis (P76.0)
       E84.19 Cystic fibrosis with other intestinal manifestations
          Distal intestinal obstruction syndrome
    E84.8 Cystic fibrosis with other manifestations
    E84.9 Cystic fibrosis, unspecified

## E85 AmyloidosisE85 Amyloidosis

    Excludes1: Alzheimer's disease (G30.0-)
    E85.0 Non-neuropathic heredofamilial amyloidosis
       Familial Mediterranean fever
       Hereditary amyloid nephropathy
    E85.1 Neuropathic heredofamilial amyloidosis
       Amyloid polyneuropathy (Portuguese)
    E85.2 Heredofamilial amyloidosis, unspecified
    E85.3 Secondary systemic amyloidosis
       Hemodialysis-associated amyloidosis
    E85.4 Organ-limited amyloidosis
       Localized amyloidosis
    E85.8 Other amyloidosis
    E85.9 Amyloidosis, unspecified

## E86 Volume depletionE86 Volume depletion

    Excludes1: dehydration of newborn (P74.1)
       hypovolemic shock NOS (R57.1)
       postprocedural hypovolemic shock (T81.1)
       traumatic hypovolemic shock (T79.4)
    E86.0 Dehydration
    E86.1 Hypovolemia
       Depletion of volume of plasma
    E86.9 Volume depletion, unspecified

## E87 Other disorders of fluid, electrolyte and acid-base balanceE87 Other disorders of fluid, electrolyte and acid-base balance

    Excludes1: diabetes insipidus (E23.2)
       electrolyte imbalance associated with hyperemesis gravidarum (O21.1)
       electrolyte imbalance following ectopic or molar pregnancy (O08.5)
       familial periodic paralysis (G72.3)
    E87.0 Hyperosmolality and hypernatremia
       Sodium [Na] excess
       Sodium [Na] overload
    E87.1 Hypo-osmolality and hyponatremia
       Sodium [Na] deficiency
       Excludes1: ​syndrome of inappropriate secretion of antidiuretic hormone (E22.2)
    E87.2 Acidosis
       Acidosis NOS
       Lactic acidosis
       Metabolic acidosis
       Respiratory acidosis
       Excludes1: diabetic acidosis - see categories E10-E13 with ketoacidosis
    E87.3 Alkalosis
       Alkalosis NOS
       Metabolic alkalosis
       Respiratory alkalosis
    E87.4 Mixed disorder of acid-base balance
    E87.5 Hyperkalemia
       Potassium [K] excess
       Potassium [K] overload
    E87.6 Hypokalemia
       Potassium [K] deficiency
    E87.7 Fluid overload
       Excludes1: edema NOS (R60.-)
    E87.8 Other disorders of electrolyte and fluid balance, not elsewhere classified
       Electrolyte imbalance NOS
       Hyperchloremia
       Hypochloremia

## E88 Other and unspecified metabolic disordersE88 Other and unspecified metabolic disorders

    Use additional codes for associated conditions
    Excludes1: histiocytosis X (chronic) (C96.6)
    E88.0 Disorders of plasma-protein metabolism, not elsewhere classified
       Excludes1: disorder of lipoprotein metabolism (E78.-)
          monoclonal gammopathy (of undetermined significance) (D47.2)
          polyclonal hypergammaglobulinemia (D89.0)
          Waldenström macroglobulinemia (C88.0)
       E88.01 Alpha-1-antitrypsin deficiency
          AAT deficiency
       E88.09 Other disorders of plasma-protein metabolism, not elsewhere classified
          Bisalbuminemia
    E88.1 Lipodystrophy, not elsewhere classified
       Lipodystrophy NOS
       Excludes1: Whipple's disease (K90.81)
    E88.2 Lipomatosis, not elsewhere classified
       Lipomatosis NOS
       Lipomatosis (Check) dolorosa [Dercum]
    E88. ​3 Tumor lysis syndrome
       Tumor lysis syndrome (spontaneous)
       Tumor lysis syndrome following antineoplastic drug chemotherapy
       Code first (T45.1-) to identify drug, if drug induced
    E88.4 Mitochondrial metabolism disorders
       Excludes1: disorders of pyruvate metabolism (E74.4)
          Kearns-Sayre syndrome (H49.81)
          Leber's disease (H47.22)
          Leigh's encephalopathy (G31.82)
          Mitochondrial myopathy, NEC (G71.3)
          Reye's syndrome (G93.7)
       E88.40 Mitochondrial metabolism disorder, unspecified
       E88.41 MELAS syndrome
          Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes
       E88.42 MERRF syndrome
          Myoclonic epilepsy associated with ragged-red fibers
          Code also: myoclonic epilepsy (G40.3-)
       E88.49 Other mitochondrial metabolism disorders
    E88.8 Other specified metabolic disorders
       E88.81 Metabolic syndrome
          Dysmetabolic syndrome X
       E88.89 Other specified metabolic disorders
          Launois-Bensaude adenolipomatosis
    E88.9 Metabolic disorder, unspecified

## E89 Postprocedural endocrine and metabolic complications and disorders, not elsewhere classifiedE89 Postprocedural endocrine and metabolic complications and disorders, not elsewhere classified

    Excludes2: intraoperative complications of endocrine system organ or structure (E36.0-, E36.1-, E36.8)
    E89.0 Postprocedural hypothyroidism
       Postirradiation hypothyroidism
       Postsurgical hypothyroidism
    E89.1 Postprocedural hypoinsulinemia
       Postpancreatectomy hyperglycemia
       Postsurgical hypoinsulinemia
       Use additional code, if applicable, to identify:
          acquired absence of pancreas (Z90.89)
          diabetes mellitus (E11.-)
          insulin use (Z79.4)
       Excludes1: transient postprocedural hyperglycemia (R73.9)
          transient postprocedural hypoglycemia (E16.2)
    E89.2 Postprocedural hypoparathyroidism
       Parathyroprival tetany
    E89.3 Postprocedural hypopituitarism
       Postirradiation hypopituitarism
    E89. ​4 Postprocedural ovarian failure
       E89.40 Asymptomatic postprocedural ovarian failure
          Postprocedural ovarian failure NOS
       E89.41 Symptomatic postprocedural ovarian failure
          Symptoms such as flushing, sleeplessness, headache, lack of concentration, associated with postprocedural menopause
    E89.5 Postprocedural testicular hypofunction
    E89.6 Postprocedural adrenocortical (-medullary) hypofunction
    E89.8 Other postprocedural endocrine and metabolic complications and disorders
       E89.81 Postprocedural hemorrhage and hematoma of an endocrine system organ or structure following a procedure
          E89.810 Postprocedural hemorrhage and hematoma of an endocrine system organ or structure following an endocrine system procedure
          E89.811 Postprocedural hemorrhage and hematoma of an endocrine system organ or structure following other procedure
       E89.89 Other postprocedural endocrine and metabolic complications and disorders
          Use additional code, if applicable, to further specify disorder