# Radiation Oncology/Lymphoid

* Front Page: Radiation Oncology | RTOG Trials | Randomized Trials
Hematologic Malignancies

## Chapter Links

Indications
* Hodgkin lymphoma
* Non-Hodgkin lymphoma
* Primary CNS lymphoma
* Cutaneous lymphomas
* Leukemia
** Chloroma (Granulocytic sarcoma)
* Multiple myeloma and plasmacytoma
* Waldenstroms macroglobulinemia
* Langerhans' Cell Histiocytosis
Technique
* Spleen Irradiation
* Total Body Irradiation
* Miscellaneous

## Conceptual Simplified Classification
### Lymphoid Disorders

* Acute lymphocytic leukemia (ALL)
* Chronic lymphoproliferative disorders
** Hodgkin's disease (HD)
** Non-Hodgkin's lymphoma (NHL)
** Multiple Myeloma
** Chronic lymphoid leukemias (CLL)

### Myeloid Disorders

* Acute myeloid leukemia (AML)
* Chronic myeloid disorders
** Myeloproliferative disease (MPD)
*** Chronic myelogenous leukemia (CML)
*** Polycythemia vera
*** Essential thrombocythemia
** Myelodysplastic/myeloproliferative diseases
** Myelodysplastic syndromes (MDS)

## WHO classification
### Myeloid Neoplasms

* Acute myeloid leukemia (AML)
* Acute biphenotypic leukemias
* Myeloproliferative disease
** Chronic myelogenous leukemia (CML)
** Chronic neutrophilic leukemia
** Chronic eosinophilic leukemia/hypereosinophilic syndrome
** Chronic idiopathic myelofibrosis
** Polycythemia vera
** Essential thrombocythemia
** Myeloproliferative disease, unclassifiable
* Myelodysplastic/myeloproliferative diseases
** Chronic myelomonocytic leukemia
** Atypical chronic myelogenous leukemia
** Juvenile myelomonocytic leukemia
* Myelodysplastic syndromes (MDS)
** Refractory anemia
** With ringed sideroblasts
** Without ringed sideroblasts
** Refractory cytopenia
** Refractory anemia
** 5q- (5q deletion) syndrome
** Myelodysplastic syndrome, unclassifiable

### Lymphoid: B-cell neoplasms

* Precursor B-cell neoplasms
** Precursor B-lymphoblastic leukemia/lymphoma
** Precursor B-cell acute lymphoblastic leukemia
* Mature (peripheral) B-cell neoplasms
** B-cell chronic lymphocytic leukemia / small lymphocytic lymphoma
** B-cell prolymphocytic leukemia
** Lymphoplasmacytic lymphoma
** Splenic marginal zone B-cell lymphoma
** Hairy cell leukemia
** Plasma cell myeloma/plasmacytoma
** Extranodal marginal zone B-cell lymphoma of MALT type
** Nodal marginal zone B-cell lymphoma
** Follicular lymphoma
** Mantle cell lymphoma
** Diffuse large B-cell lymphoma
** Burkitt lymphoma / Burkitt cell leukemia

### Lymphoid: T-cell and NK-cell neoplasms

* Precursor T-cell neoplasm
** Precursor T-lymphoblastic lymphoma/leukemia
** Precursor T-cell acute lymphoblastic leukemia
* Mature (peripheral) T/NK-cell neoplasms
** T-cell prolymphocytic leukemia
** T-cell granular lymphocytic leukemia
** Aggressive NK-cell leukemia
** Adult T-cell lymphoma/leukemia (HTLV1+)
** Extranodal NK/T-cell lymphoma, nasal type
** Enteropathy-type T-cell lymphoma
** Hepatosplenic gamma-delta T-cell lymphoma
** Subcutaneous panniculitis-like T-cell lymphoma
** Mycosis fungoides / Sezary syndrome
** Anaplastic large cell lymphoma, T/null cell, primary cutaneous type
** Anaplastic large cell lymphoma, T/null ell, primary systemic type
** Peripheral T-cell lymphoma, not otherwise characterized
** Angioimmunoblastic T-cell lymphoma

### Lymphoid: Hodgkin Lymphoma

* Nodular lymphocyte-predominant Hodgkin lymphoma
* Classical Hodgkin lymphoma
** Nodular sclerosis Hodgkin lymphoma (grades 1 and 2)
** Lymphocyte-rich classical Hodgkin lymphoma
** Mixed cellularity Hodgkin lymphoma
** Lymphocyte depletion Hodgkin lymphoma

### Lymphoid: Posttransplant Lymphoproliferative Disorders

* Early lesions
** Reactive plasmacytic hyperplasia
** Infectious mononucleosis-like
* PTLD polymorphic
** Polyclonal (rare)
** Monoclonal
* PTLD monomorphic (classify according to lymphoma classification)
** B-cell lymphomas
** T-cell lymphomas
* Other types (rare)

### Mast Cell Disorders

* Cutaneous mastocytosis
* Systemic mast cell disease (+/- skin involvement)
* Systemic mast cell disease with associated hematologic disorder (+/- skin involvement)
* Mast cell leukemia/sarcoma

### Histiocytic and Dendritic Cell Neoplasms

* Macrophage/Histiocytic neoplasm
** Histiocytic sarcoma
* Dendritic-cell neoplasms
** Langerhans cell histiocytosis
** Langerhans cell sarcoma
** Interdigitating dendritic cell sarcoma/tumor
** Follicular dendritic cell sarcoma/tumor
** Dendritic cell sarcoma, not otherwise specified