OpenLLM-France/wikimedia huggingface dataset:
# The Devonshire Manuscript/Yowre ferefull hope cannot prevayle

* ←My ferefull hope from me ys fledd || width="200" align="right" | Bownd am I now & shall be styll→
* The Devonshire Manuscript facsimile 8r LDev010
f. [8r] 1{9}{p'} {_u} 3secundusYowre ferefull hope cannot prevayle 2 nor yet faythfull trust Also 3 sum thynke to hytt oftymes do fayle 4 wherby they change theyre welthe to wo 5 What tho In that yet put no trust 6 but allways after as ye see 7 for say yo$^r$ wyll & do yo$^r$ lust 8 there ys no place for yow to be 9 No sure therin ye ar farr owte 10 yo$^r$ labor lost ye hope to save 11 but ons I put ye owt off dowte 12 the thyng ys had that ye wold have 13 tho to Remayn with{w+t+}owt Remorce 14 & petyles to be opprest 15 yet ys the coorse of love by force 16 to take all thynges{es} vnto the best 17 Well yet beware yff thow be wysse 18 & leve thy hope thy hete to coole 19 ffor fere lest she thy love dyspyse 20 reputyng the but as a ffole 21 syns thys to folow of force thow must 22 & by no Reason can Refrayn 23 thy chawnce shall change thy lest mystrust 24 as thow shalt prove vnto thy payn 25 When wythe suche payn thow shalt be payd 26 the whyche shall passe all Remedy 27 then thynke on thys that I have sayd 28 & blame thy folysshe ffantasy fynys quod{q+d+}s e$^1$

## Notes & Glosses

1. Standard witness indexes indicate that the obscured word here is "somebody," corresponding to the attribution to "nobody" in the corresponding poem, "My ferefull hope from me ys fledd" (7v).

## Commentary

This poem remains unattributed and may be an original creation unique to this manuscript. Entered by H2, this poem is the second of a question/answer pair placed on facing pages, marked first (primus) and second (secundus) by an unidentified hand, and with possibly corresponding attributions. The speaker cautions the narrator of the preceding poem to put his trust in what he can see and not what he imagines.
# The Devonshire Manuscript/but now helpe god to quenche all thys sorow

* ←for who so ends || width="200" align="right" | ffortyn ells→
* The Devonshire Manuscript facsimile 93r
f. [93r] 1 but now helpe god to quenche all ayall thys sorow

## Commentary

This entry is an excerpt from Chaucer's Troilus and Criseyde (Book III, line 1058). TH2 most likely copied from Thynne's edition of Chaucer (c. 1532). The page was torn lengthwise, which removed some writing. The scribe most likely entered the line of verse on four graphical lines after the page was torn. The page was probably torn during the time of active involvement in the compilation since the style of handwriting matches the rest of the manuscript.
The Devonshire Manuscript contains numerous other verses from Troilus and Criseyde (see: "And now my pen alas wyth wyche I wryte" (29v(1)), "O very lord / o loue / o god alas" (29v(2)), "O ye louers that hygh vpon the whele" (30r), "for thylke grownde that bearyth the wedes wycke" (59v), "yff yt be so that ye so creuel be" (91r(2)), "Wo worthe the fayre gemme vertulesse" (91v(1)), "for loue ys yet the moste stormy lyfe" (91v(2)), and "Also wyckyd tonges byn so prest" (91v(3)), and "And who that sayth that for to love ys vyce" (92r).Other medieval and Chaucerian excerpts in the manuscript, possibly copied from Thynne's edition, include selections from Hoccleve ("Womans harte vnto no creweltye" (89v(1)) and "ys thys afayre / ys thys honor" (89v(2)), Richard Roos' La Belle Dame Sans Merci ("O marble herte and yet more harde perde" (90r(1)) and "Alas what shuld yt be to yow preiudyce" (90r(2)), the Chaucerian Remedy of Love first printed in Thynne's edition ("yff all the erthe were parchment scybable" (90r), and Chaucer's Anelida and Arcite ("for thowgh I had yow to morow agayne" (91r)).

## Textual Notes
#### Texts Collated

T5068.05

#### Collation

1 but now helpe god to quenche all ayall thys sorow] But nowe helpe god/to quenche al this sorow T5068.05
# The Devonshire Manuscript/am el mem

* ←The pleasaunt beayt of swet Delyte Dothe blynd || width="200" align="right" | the sueden ghance ded mak me mves→
* The Devonshire Manuscript facsimile 67v
* The Devonshire Manuscript facsimile 66v
* The Devonshire Manuscript facsimile 67r
f. [66v] f. [67r] f. [67v] 1 am el mem 2 anem e 3 as I haue dese 4 I am yowrs an$^1$

## Notes & Glosses

1. This phrase might refer to Anne Boleyn.

## Commentary

Entered by TH2, this anagram is possibly a reply by Anne Boleyn to Wyatt’s “What word is that that changeth not though it be turned,” – the answer is ANNA. Thus, the first and fourth letters of the first two lines must be interchanged to decipher the anagram, which reads, “a lemmen, amene, ah I save dese, I ama yours, an.” This anagram might suggest allegiances between various members of the manuscript’s coterie and those on the periphery. Anne Boleyn’s mottos are mentioned in some verses: H8’s transcription of Wyatt’s poem “Ye know my herte my ladye dere” (73v) contains Boleyn’s motto “Me and Myne,” and “Grudge on who liste this ys my lott” (78v) also contains an earlier motto of Boleyn’s from her time at the Burgundian court.

#### Works Cited

* ↑ R.A. Rebholz, ed. Sir Thomas Wyatt: The Complete Poems. London: Penguin, 1978. 436.
# The Devonshire Manuscript/fancy framed my hart ffrust

* ←ffanecy fframed my hart ffurst || width="200" align="right" | In places Wher that I company→
* The Devonshire Manuscript facsimile 62r
f. [62r] 1 fancy framed my hart ffrust 2 to bere good m wyll and seke the same 3 y sowght the best and ffownd the worst 4 yet ffansy gioye

## Commentary

This poem, entered by H12, remains unattributed. The entry consists of three full lines and an incomplete fourth line from the preceding poem. The entry directly above it on the same page, Written in Margaret Douglas's hand, provides a seemingly complete version of the poem. Both examples show indications of revision by an unidentified hand. An annotation, “gioye,” appears under the poem in the same hand that has revised the poem above.

## Textual Notes
#### Texts Collated

LDev096

#### Collation

1 fancy] ffanecy LDev096 framed] fframed LDev096 ffrust] ffeuurst LDev096 2 m wyll] wyll LDev096 seke] sechee LDev096 3 y] I LDev096 worst] wo^urst LDev096 4 yet ffansy] yet ffansy was no delle to blame LDev096 5 ] ffor ffancy hawe a dobell neame LDev096 6 ] and has her neame so ys her kynd LDev096 7 ] ffancy a ffoo and ffancy a ffreynd LDev096 8 ] ffancy ffolowyd all my desyer LDev096 9 ] to lyk wher as I had best lust LDev096 10 ] what cold I mor off her requyrer LDev096 11 ] than ffor that thyng wyche ueds Iniust LDev096 12 ] and fforsyth me styl ffor to be Iust LDev096 13 ] in thys she showyd her selff my ffreynd LDev096 14 ] to mak me lord off my nown mynd LDev096 15 ] thys ffraned ffancy LDev096 15.1 ] thys ffayned ffancy at the last LDev096 16 ] hath ca^usyd me ffor to beware LDev096 17 ] off wyndy words and bablyng blast LDev096 18 ] wych b hath offtymes cast me in snare LDev096 19 ] and broght me ffrom my yyoy to care LDev096 20 ] wherffor I mak thys promes now LDev096 21 ] to brek my ffancy and nat to bowe LDev096
# The Devonshire Manuscript/ffanecy fframed my hart ffurst

* ←Go burnynge siths vnto the frosen hert || width="200" align="right" | fancy framed my hart ffrust→
* The Devonshire Manuscript facsimile 61v
* The Devonshire Manuscript facsimile 62r
f. [61v] 1 ffanecy fframed my hart ffeu$^{ur}$st 2 to bere good wyll and seche the same 3 I sowght the best and ffownd the wo$^u$rst 4 yet ffansy was no dell to blame 5 ffor ffancy hawe a dobell ne$^a$me 6 and has her ne$^a$me so ys her kynd$^1$ 7 ffancy a ffoo and ffancy a ffrend$^2$ f. [62r] 8 ffancy ffolowyd all my desyer 9 to lyk wher as I had best lust 10 what cold I mor off her requyr 11 than ffor that thyng wyche neds I must 12 and fforsyt me styl ffor to be Iust 13 in thys she showyd her selff my ffrend$^3$ 14 to mak me lord off my nown mynd 15 [thys ffraned ffancy] 15 thys ffayned ffancy at the last 16 hath ca$_^$$^u$syd me ffor to beware 17 off wyndy words and bablyng blast 18 wych [b] hath offtymes cast me in snare 19 and broght me ffrom my yoy$^4$ to care 20 wherffor I mak thys promes now 21 to brek my ffancy and nat to bowe

## Notes & Glosses

1. The 'y' in 'kynd' has two dots over it.
 2. The 'y' in 'ffrynd' has two dots over it.
 3. The 'y' in 'ffrynd' has two dots over it.
 4. The 'y' in 'yoy' has two dots over it.

## Commentary

Written in Margaret Douglas's hand, this poem remains unattributed. H12 enters the first three lines of the poem and part of the fourth line directly below the last stanza of this poem on "fancy framed my hart ffrust" (62r). Both examples show indications of revision by an unidentified hand. "ffanecy fframed my hart ffurst" explores the common courtly trope of fancy. In this case, fancy is both foe and friend to the lover.

## Textual Notes
#### Texts Collated

LDev097

#### Collation

ffanecy] fancy LDev097 fframed] framed LDev097 ffeuurst] ffrust LDev097 2 wyll] m wyll LDev097 sechee] seke LDev097 3 I] y LDev097 wo^urst] worst LDev097 4 was no delle to blame] LDev097 5 ffor ffancy hawe a dobell neame] LDev097 6 and has her neame so ys her kynd] LDev097 7 ffancy a ffoo and ffancy a ffreynd] LDev097 8 ffancy ffolowyd all my desyer] LDev097 9 to lyk wher as I had best lust] LDev097 10 what cold I mor off her requyrer] LDev097 11 than ffor that thyng wyche ueds Iniust] LDev097 12 and fforsyth me styl ffor to be Iust] LDev097 13 in thys she showyd her selff my ffreynd] LDev097 14 to mak me lord off my nown mynd] LDev097 15 thys ffraned ffancy] LDev097 15.1 thys ffayned ffancy at the last] LDev097 16 hath ca^usyd me ffor to beware] LDev097 17 off wyndy words and bablyng blast] LDev097 18 wych b hath offtymes cast me in snare] LDev097 19 and broght me ffrom my yyoy to care] LDev097 20 wherffor I mak thys promes now] LDev097 21 to brek my ffancy and nat to bowe] LDev097
# The Devonshire Manuscript/ffor to love her for her lokes lovelye

* ←Nowe fare well love and theye lawes forever || width="200" align="right" | To Rayle or geste ye kno I vse yt not→
* The Devonshire Manuscript facsimile 75r
f. [75r] 1 ffor to love her for her lokes{es} lovelye 2 my herte was sett in thought right furmlye 3 trusting bye to$^r$uthe trouthe to have had Relessed redresse / 4 but she hath made anodre promes 5 and hathe gyven me leve full honestelye 6 yet do I not refuse yt gretelye 7 for on my faith I lovid so surelye 8 but reson woll that I doo leese 9 for to love her. 10 sins that in love the paynes be dedelye 11 me thinckes{es} yt best that reddelye 12 I doo reto$^r$ne to my furst addresse 13 for at this tyme to grete is the presse 14 and parells apere to abbund$^a$untelye 15 for to love her.

## Commentary

Attributed to Sir Thomas Wyatt, this poem was entered by H8. The speaker judges that the perils of loving the lady are too great; thus, he will reasonably return to a lighter, more courteous demeanor toward her (“my furst addresse”). This poem provides an interesting glimpse into the different manners and consequences of addressing a lady.

#### Works Cited

* ↑ R.A. Rebholz, ed. Sir Thomas Wyatt: The Complete Poems. London: Penguin, 1978. 223.

## Textual Notes
#### Texts Collated

LEge10

#### Collation

1 lovelye] lovely LEge10 2 herte] hert LEge10 sett] set LEge10 furmlye] fermely LEge10 3 bye toruthe] by LEge10 trouthe] trought LEge10 Relessed redresse /] redresse LEge10 4 anodre] an othee LEge10 promes] promese LEge10 5 hathe] hath LEge10 gyven] geven LEge10 love] leve LEge10 honestelye] honestly LEge10 6 refuse yt gretelye] reioyse it greately LEge10 7 lovid] loved LEge10 so] to LEge10 surelye] surely LEge10 8 reson] reason LEge10 woll] will LEge10 doo loosse] do sesse LEge10 9 her.] her> LEge10 10 sins] Syns LEge10 be dedelye] ben dedly LEge10 11 thinckes] thincke LEge10 yt] it LEge10 riddelye] reddely LEge10 12 doo] do LEge10 retorne] retorn LEge10 furst] first LEge10 addresse] adresse LEge10 13 grete] great LEge10 presse] prese LEge10 14 parells] perilles LEge10 apere] appere LEge10 abbundauntelye] abundauntely LEge10 15 her.] her LEge10
# The Devonshire Manuscript/and thys be thys ye may

* ←what nedythe lyff when I requyer || width="200" align="right" | Too yoye In payne my will→
* The Devonshire Manuscript facsimile 44r
f. [44r] 1 and thys be thys ye may 2 asuer your selff off me 3 no thyng shall ^$^1$$^{make}$ me to deney 4 that I hawe promest the$^2$

## Notes & Glosses

1. This is an inverse caret.
 2. This is a resonant phrase.

## Commentary

Written in Margaret Douglas' hand, this poem remains unattributed and is unique to this manuscript. The single quatrain depicts a steadfast promise to a lover.
# The Devonshire Manuscript/as ffor my part I know no thyng

* ←ther ys no cure ffor care off miyd || width="200" align="right" | to my meshap alas I ffynd→
* The Devonshire Manuscript facsimile 41r
* The Devonshire Manuscript facsimile 41v
f. [41r] 1 as ffor my part I know no thyng 2 wether that ye be bond or ffre 3 but yet off lat a bvrd ded syng 4 that ye had lost your leberty f. [41v$^1$] 5 yff yt be tru take hed be tym$^2$ 6 and yff thow mast onestly ffly 7 leve off and slake $^{thys}$ ffowlese crym 8 that towcht moch thyn on$^e$sty 9 I spek not thys to know your mynd 10 nor off your coun{_u}sell ffor to be 11 but yff I wer thow shold me ffynd 12 thy ffaythffull ffrend asesuredly

## Notes & Glosses

1. The top inch of the page has been cut and repaired.
 2. For this wording, see Wyatt's poem "Take hede be tyme lest ye be spyde" (2r).

## Commentary

Written in Margaret Douglas's hand, this poem remains unattributed and is unique to this manuscript. The speaker offers to be available for “counseling” a lover in need. Douglas's writing for the first stanza on "ther ys no cure ffor care off miyd" (41r) appears so faintly on the page that it becomes almost unreadable.
# Structural Biochemistry/Cell Organelles/Proteins
### Amino Acids

Proteins have a lot of uses in the body. from cell structure to carrying out reactions. Proteins are in turn made of smaller building blocks called amino acids. There are a total of 20 amino acids.
Proteins can be made from a lots of different combinations and number of amino acids. This creates an almost infinite amount of different proteins. Although the sequence of amino acids is a chain, the structure of proteins is far from similar. These amino acids interact with each other to form #D structures. Most common are the alpha helix and the beta strand.
Although it is possible to determine the 3D structure of a protein, it is not quite possible to predict protein structure from the amino acid chain. This is quite important because diseases such as Alzheimer's and Mad Cow Disease are thought to come from a misfolding of proteins.

## References

* ↑ The Structures of Life, NIH Publication No. 07-2778
# Structural Biochemistry/Cell Organelles/RNA

RNA
RNA has many different functions. The major three are rRNA (ribosomal RNA) which is the most abundant and helps form ribosomes, mRNA which takes the transcribed message from the DNA and sends it through a ribosome for it to be translated into a protein and tRNA which attaches amino acids based on the codon that was on the mRNA. However a recently discovered function of RNA is RNAi (RNA interference).
RNA Interference
RNA interference was accidently discovered by trying to make a plant's flower more purple. Scientist took the gene to make a plant's flower purple and placed it in the plant's cell. A few days later they realized that instead of a purple flower they got a white flower. This surprised scientist until recently they discovered RNAi. RNAi is like the cop of the cell and whenever a virus comes in and spreads their own RNA, the RNAi see this as looking mysterious and destroys it and everything that looks like it. This is exactly what happened to the scientist trying to darken the color of the flower. The plant saw the new gene that the mRNA was transcribing from the DNA as mysterious and possible a virus so the RNAi destroyed that gene and every other gene that looked like it. Hence, all the color genes for the flower were destroyed so the flower turned out to be white. Now that scientist have discovered this they plan on using this to their advantage for possibly fighting cancer and HIV. There has been one case where an elderly lady was becoming blind because her eyes were creating too much blood cells and her vision was becoming very blurry. So scientist tested the RNAi and placed a gene in her eye cell to create more blood cells. The RNAi saw this gene and thought it was a virus and dangerous to the body so the RNAi destroyed that gene and all other genes like it. Her eye cells have been producing less amount of blood cells and her vision has been getting better. RNAi is a very interesting function for RNA and is still being studied today to possibly help other patients with more severe diseases.
# Transportation Systems Simulation - A Tutorial for Multi-Modal Simulation Using VISSIM/Freeway: Simulation

Before running a simulation, assure that each previous section has been implemented. The following section is the most basic method of extracting simulation data from VISSIM.
* Identify where the simulation data will be saved by selecting Evaluation > Configuration from the top toolbar (see Figure below)
* Click the “…” button and select the location/folder as your desired output directory
* Click OK
* Click OK
Set the “Simulation Parameters” by selecting Simulation > Parameters from the top toolbar (see Figure below)
| Period = | 10800 for 3 hours or 7200 for 2 hours |
| Simulation resolution = | 10 |
| Random Seed = | Random # |
| Number of runs = | 1 |
| Simulation speed = | maximum |
| Number of cores = | use all cores |
Click OK
TIP: Higher “Simulation resolution” values will result in smother simulations while requiring more resources. Consider changing the seed to avoid similar results.
* Select the “Data Collection Measurement” tab below the Network Editor
* Click the “Autosave after simulation” button
TIP: To manually save simulation data, Click the “Save to file” button located left of the “Autosave” button
* On the top toolbar, Select Simulation > Continuous …sit back and watch the simulation run (see Figure below)
** If VISSIM prompts the user to “Save changes?” Click Yes
* While the simulation is running, make a note of the following vehicular characteristics:
** Vehicles are entering and exiting through the appropriate locations
** HGV are generated by the simulation
** Look for unusual behavior (stuck vehicles, merging issues, disappearing vehicles, unused lanes, connector issues …)
* Watch the entire simulation carefully, zoom in and out to locate trouble areas
* Let the entire simulation finish to automatically save the results
* Values will being to generate in the “Data Collection Measurement” window as the simulation runs
Back to Main Page
# Transportation Systems Simulation - A Tutorial for Multi-Modal Simulation Using VISSIM/Bicycle: Geometric Network Design

Bicycle simulation works using the same network object infrastructure as vehicle simulation. Vehicle compositions can be changed to add a percentage of bicycles if mixed flows are desired. To add dedicated bike lanes, use links to run adjacent to vehicle links and model conflict points where vehicle and bike lane links cross. The three procedures explained in this section that relate to bicycle simulation are to add bikes to vehicle compositions, create bike lane links, and model bike conflict zones, and model mixed flow to bike only routing decisions. This section adds additional links to the theshoppesbase model updated in the previous sections to model dedicated bike lanes.

## Create Bike Lane Links

* Click on the network object Links.
* Then CTRL + Right Click to place the starting point and Click to place the ending point.
* Place the bicycle link (see Figure below) and type “bike lane” in the Name: text box.
* Type “4” in the Width input.
* Click OK.
* After the link is placed, put a connector between the vehicle link and bike lane line (see Figure below)
      * Right Click the start link then Click the ending link.
      * Leave the attributes as default.
      * Click OK.
Back to Main Page
# Transportation Systems Simulation - A Tutorial for Multi-Modal Simulation Using VISSIM/Bicycle: Traffic Data Input

To create the proper bike lane behavior, routes and conflict areas need to be modeled. First, place two new and separate static vehicle routes as shown below. One route directs vehicles to continue straight through without bicycles, and the other route directs only bicycles to diverge into the bicycle lane.

## Add Bikes to Vehicle Compositions

* Go to Traffic > Vehicle Compositions to open the list window. Make sure the Relative Flows sub list is chosen from the dropdown menu.
* Right Click in the main list and Click Add… to add a new vehicle composition.
* Then Right Click in the sub list and Click Add to add a new vehicle type, in this case bicycle.
* Choose the speed distribution and relative flow (see Figure below). When defining vehicle inputs use the shoppesdata.xlsx vehicle composition.

## Place Bicycle Routes

* Click on Vehicle routes network object.
* Right Click on the link prior to the bike lane divergence, then Click on the vehicle link past the divergence.
* Repeat this process one time, except Click on the bicycle link past the divergence (see Figure below).
* Next, Uncheck AllVehTypes for each of these new routes.
* For the vehicle route choose all the vehicle classes, for the bike lane choose only the 60: Bike vehicle class.
To model the conflict areas use the same procedure using the Conflict Areas network object. Give priority to the bikes by using Set Status to 1 Waits for 2.
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