OpenLLM-France/wikimedia huggingface dataset:
# The Legend of Zelda: Link's Awakening (2019 video game)/Easter Eggs
## Animal Assault

You can needlessly place Link in danger by attacking foxes. A single strike will result in a swift rebuke, dealing a half heart of damage. You can also place Link in more danger by attacking the Cucco birds around two. An accidental strike or several will not trigger this, but do it enough, and they'll launch a relentless retaliation for your bullying. A swarm of Cuccos will decent upon Link! Every time a Cucco hits Link, it deals a half heart of damage. Linkcan go inside a building to stop the assault, with a lesson learned.
# The Legend of Zelda: Link's Awakening (2019 video game)/Exploring Animal Village
## Finding Animal Village

Head back the stairs used to cross the river, but do not descend down them. Instead head south to find the Animal Village. If you reach the telephone booth, you've gone too far and should return north.

## Animal Village

Animal Village is the quirky "Sister City" of Mabe Village. The inhabitants here are not human, but are still friendly to Link.
In the Animal Village, talk to the snow white rabbit near the entrance. This rabbit wants a song from Marin.
In the northwestern house a white rabbit inside will mention a way to the south, which is said to be blocked by a walrus.
The next building to the east houses the crocodile (Or is it an Alligator?) artist Schule Donavitch, as well as a hippo model. Schule Donavitch mentions he made the mermaid statue at Martha's Bay as his unfinished masterpiece. The Hippo Model is less talkative.
The next eastern neighbor is the goat Christine. Concerned with etiquette, she wants flowers. Specifically she wants a pink hibiscus before she will talk to Link. Her house shares a leitmotif with Mr. Write.
The neighboring house to the east is... empty? Looks can be deceiving, but leave for now.
The rabbit in the southeast corner is concerned for Marin, since the monsters have stopped visits between the two villages.
Enter the house in the southeast to meet Chef Bear. Chef Bear wants Link's Honeycomb, and is willing to trade in exchange for a Pineapple. Chef Bear tells Link to fetch Marin to get the walrus blocking the way to move. Chef Bear may also mention their plans to open a Mabe Village branch.
Head to the very south of Animal Village to activate a convenient warp pedestal. Warp back to the Ukuku Prairie to get a shortcut to Mabe Village.

## Questions

* What is good etiquette?
* What leads to a city having a sister city?
← Ancient Ruins Exploration · Journey with Marin →
# The Legend of Zelda: Link's Awakening (2019 video game)/Getting Started
## Technical Notes

This guide covers version 1.01 of the game, running on an original Nintendo Switch. This guide should also be applicable to the Switch Lite.
This game is available as either a physical cartridge, or as a digital download. Be aware that this game takes up 5.9 gigabytes of space as a download. This download can fit on either Internal System Storage, a MicroSD card, provided there is enough free space available. The game can't be split across both, so if you have 5 gigabytes of free space on internal storage, and 2 gigabyte of free space on your microSD card, you'll need to either shuffle or delete some data until you have 5.9 gigabytes of free space on a single storage medium.

## Starting the Game

When you start the game, an animated cutscene will play. After this ends, you'll see the title screen, and you can press L and R at the same time to proceed.
You will see three save slots, as well as an autosave slot. Since the Switch supports multiple user profiles, these are more for keeping track of multiple playthroughs or game states then for supporting multiple users. A gamer with their own profile gets their own save slots! A single user can also create another profile to gain additional slots for more playthroughs. Choose one and proceed.
When you select an empty slot you will be asked to select a difficulty level. There are two options to pick from.
* Normal - The default, and the one this guide assumes you will be playing on.
* Hero - This increases the difficulty quite a bit. There are no heart drops, and Link takes twice as much damage as normal. A Hero mode save is decorated with a monster head next to your name.
Next you will be asked to enter your name. By default your name is Link. This guide will call the character Link, but you should name your character whatever you want!
Confirm the name, and jump into the game.

## References

* ↑ "The Legend of Zelda: Link's Awakening for Nintendo Switch - Nintendo Game Details". www.nintendo.com. Retrieved 14 June 2021.
Wake Up! →
# The Legend of Zelda: Link's Awakening (2019 video game)/Dream Shrine
## Dream Shrine

Head to Dream Shrine in north Mabe Village. Go inside and go to bed to enter the true shrine. To beat the enemies without breaking the cracks, use the Pegasus boots to dash through. In the center right of the chamber, the right chest contains a silver rupee worth 100 rupees. Break the crystal with the dash and head left to pick up the ocarina. Currently Link doesn't know how to play, but you can still use the ocarina to hear a comical tune.

## Marin's Song

Head outside to meat Marin by the rooster statue. Talk to her and she will ask Link to accompany her in a song. Marin vocalizes the Ballad of the Wind Fish and Link manages to follow amazingly well. After confirming Link knows the song, Marin asks Link to remember it and to play it every so often.
On the phone Old Man Ulrira mentions the Angler Key can be found in the Yarna Desert.

## Optional Tasks

After Key Dungeon visit Dampe's shack to update the chamber components.
Just east of Mable Village is a bombable cracked wall behind the trees next to the cliff ladder. The cracks are located the east side of the tree line, bordering the west field of holes with insect enemies that pop out to attack Link. Bomb the cracked rock to reveal a cave entrance. With the Pegasus boots Link can pop the crystals to make a way to the chest. To actually get to the chest, push the rock to the northwest of the chest to the west. Pop open the chest for a cool 50 rupees. Note the cracked wall on the east side of the room. Bomb it open and enter to find a chamber with a Piece of Heart.
In Mabe village Mamasha mentions that her husband is starving up in the mountains, where he is lost. This is just as he said earlier.
Tarin can be found recuperating from the honey incident at home, having lost his desire for honey.
The Trendy Game Shop has been updated.
With the Pegasus Boots in tow, visit the village library. Dash into the bookshelf to knock the red book down. This book is entitled The Hidden Power of Color and contains a hint for unlocking an optional dungeon.
← Key Cavern Exploration · Ancient Ruins Exploration →
# The Legend of Zelda: Link's Awakening (2019 video game)/Fishing Pond

In North Mabe Village there is a fishing pond. Talk to the Fisherman to begin fishing for only 10 rupees a try.
A sign next to the pond records record catches.

## Catches

| Catch | Guide |
| Fairy Bottle | In the bottom left hand side of the pond, a fairy bottle can be seen. Catching it is difficult, but a slow and steady approach will allow it to be snagged. Does not respawn once caught. |
| Small Red Fish | The first runt fish caught earns a piece of heart. |
| Medium Red Fish | |
| Small Green Fish | |
| Large Green Fish | |
# The Legend of Zelda: Link's Awakening (2019 video game)/Dampé
## Finding Dampé

Once the moblin cave is cleared, go east from the cave to find Dampé. Dampé introduces himself as a digger, and invites Link to his shack. Take him up on that offer and continue east to reach Dampé's shack.
Once the Bottle Grotto is complete, Dampé begins allowing Link to use the dungeon creator. Whenever Link clears a dungeon or gains a chamber stone, return to gain more building options.
Whenever Link completes a dungeon, the rupees from that dungeon are kept as a reward.

## Using the Dungeon Creator

There are four options at Dampé's, but only three before the first dungeon is made.
Complete Dungeon Arranging 101, which starts out partially completed. This serves as a tutorial to the interface.
Complete the dungeon to earn a new chamber stone containing a room with bats and four blade traps. This new dungeon room has a south opening and an eastern opening.
Complete Placing the Basics to gain a new chamber stone.
# The Legend of Zelda: Link's Awakening (2019 video game)/Exploring Mabe Village

Mabe Village is a sleepy little hamlet by the sea and is the main settlement Link visits on his journey to Koholint Island. Many important activities and characters are located here, as well as the main shop on the island.
Mabe Village is returned to quite a bit, so it pays to familiarize yourself with it. You can explore without worry of danger, so long as you don't go further south then the two people playing catch.
Press - and see your map fill in for the area. This gives you extra detail on the fly. If you enter an area and forget to check the map, it will fill in later, even if Link is not currently there.

## Villagers

Up north is an inaccessible dungeon entrance and the house of Papahl and Mamasha. Mamasha wants a Yoshi Doll from Trendy Game, but Link can't visit that shop yet. Papahl introduces himself, and notes he'll get lost in the hills later. Their four kids, Lattie, Suhni, Kidoh, and Joonya, offer helpful advice and can be found throughout the village.
See the page Town Tool Shop for more info on the store and it's shopkeeper. As Link currently has no rupees, just take a peak inside for now.
Near the center of the village is a statue of a Flying Rooster. Next to that is a house with a vigorous Bow Wow, who will bark and lunge at Link, but won't hurt him. Inside the house is Madam MeowMeow, and her pet ChowChow. The Annex houses CiaoCiao, who wants some accessories.
The Fishing Pond up north lets you fish for 10 rupees. The sign next to the pond records your records. You can't enter the building at the pond.
Outside the house to the south, Grandma Yahoo will greet you enthusiastically. Shy Old Man Ulria is inside, but can't speak to you directly due to a lack of his confidence. Go east to the Telephone booth. This introduces you to Old Man Ulria properly, who tells you to go visit the village library.
The Village Library has some books with notes on how to play the game. Check out the Atlas of Koholint Island for a complete zoomed out game map at any point of the game. There are two books you can't read right now, one which is out of reach, and one with print that is too small.
← Wake Up! · Hitting the Beach →
# Structural Biochemistry/Cell Signaling Pathways/Paracrine Signaling
## General Information

Like "para" which means near, paracrine signaling is a form of cell signaling in which the target cell is near or adjacent to the signal-releasing cell while autocrine signaling acts on surface receptors on the same cell that produced the signal.
Paracrine is the secretion of a hormone by an organ other than an endocrine gland.
Below is a figure of the Oncogenic Ras of the paracrine signaling that promotes the growth of tumor.
File:Paracrine signaling.gif Oncogenic Ras promotes the transcription of cytokine genes (the double helix), leading to elevated levels of secreted cytokines (the blue spheres) that act to modulate the immune system (yellow cells), promoting angiogenesis (purple capillaries), activating tumor stroma, the brown cells.

## Other Uses

Paracrine signaling is used in the signaling through the epithelial estrogen receptor which allows for proliferation and morphogenesis in the mammary gland. Estradiol is a major regulator of postnatal mammary gland development. It uses paracrine signaling to exert its effects through the estrogen receptor and is expressed in the mammary gland stroma and epithelium. Estradiol stimulates the secretion of prolactin by the pituitary gland and suppresses the secretion of other hormones called gonadotropins. These facts help understand that impairment of mammary gland development may be due to the mammary glands inability to react to the estradiol itself.. The signaling failure is usually a result of inactivation of the ER alpha (estrogen receptor alpha).
More conclusive tests will be needed in order to more clearly understand the mechanism behind this process, but it is clear that the ER alpha expression in the epithelium is a heterogenous process that involves using ductal cells which are triggered by estradiol processes. The ER alpha cells proliferate and act on a subtype of cells which releases paracrine signals that permit other epithelial cells to participate in growth.
Two paracrine signaling agents are growth factor and clotting factors. Growth factor signalling affects the development of tissues. An example is in insects where Allotostatin controls growth through paracrine action on the corpora allata.
In mature organisms, paracrine signaling is involved with allergen responses, tissue repair, formation of scar tissue, and blood clotting.

## References

http://molinterv.aspetjournals.org/cgi/figsearch?fulltext=secreted&resourcetype=3
Paracrine Signaling with the ER Alpha-Sonia Mallepell, Sndree Krust, Pierre Chambon, Cathrin Brisken
Estrogen Target and SourceEndocr. Rev. 2006 27:677-706-U. Ohnemus, M. Uenalan, J. Inzunza, JA Gustafsson, R. Paus
Biology online (2009), viewed 15th of November 2014, http://www.biology-online.org/dictionary/Autocrine
# Structural Biochemistry/Cell Signaling Pathways/Phosphoinositol Signaling

Inositol Phosphates are a type of mono-to-polyphosphated inisitols which act as secondary messengers in signal transduction. They play roles in cell growth, apoptosis, endocytosis, etc. There are several types of Phosphoinositol with the most prominent being inositol triphosphate (IP$_3$).

## Inositol Triphosphate

This molecule is used in conjunction with diacylglycerol (DAG) in cell signaling as a secondary messenger. However, whereas DAG stays on the lipid bilayer, inositol triphosphate is soluble in the cytoplasm with the cleaving of phosphatidylinositol 4,5-bisphosphate (PIP$_2$) which attaches it to the lipid bilayer. Once free, inositol triphosphate activates the IP$_3$ receptor on the endoplasmic reticulum triggering the release of calcium ions. The increase in calcium ions raises the level of calcium in the cytoplasm, activating the next protein in the signaling chain until a cellular response is achieved.
# Principles of Economics/Assumptions Economists Make
## Ceteris paribus

Ceteris paribus is a basic tenet of economics. In any economic analysis, we usually assume that everything outside of the problem at hand remains constant. For instance, some variables in our unemployment and inflation model will actually erase the tradeoff. This happened in the 1980s and 1990s in the United States, where there was low unemployment and low inflation at the same time. However, for the most part the model is almost always correct. Thus, for the purposes of examining those two variables, economists usually assume that all of the other possible variables effecting those remain the same. Economists call this ceteris paribus or the other things being equal assumption. When considering economics, it is helpful to first evaluate only two variables, and then to examine the effects of other upon the model.
# Principles of Economics/Demand
## Demand

(Review material from the indifference curve section if this seems unfamiliar.)
From the indifference curves we can see that people value things differently and alter what they demand (no pun intended) to best utilize their money. This naturally leads to the demand curve, which in many ways is similar to the sum of many individuals' indifference curves (but not entirely). The curve is often shaped similarly. The blue line in this graph is the basic demand curve. Note that the y axis is P, not Q2.

## Quantity demanded

The quantity demanded is a specific quantity, given a demand curve and a price level. In this graph the price level of the market for the good, P*, has been extended to the y axis, price. At any quantity and given any demand curve, there should be only one natural equilibrium quantity demanded. This point is marked Q*. No trade occurs beyond this point.

## Consumer surplus

Consumer surplus is a measure of the benefit or welfare to the consumers of trading with a particular good. It can be defined as the amount of money that they save from making the transaction, or the amount that they are willing to pay to buy the good under discussion. Different consumers have different preferences (indifference curves) and thus obtain different levels of happiness with the trade. In graphs, they are always arranged so that the most happy consumer - the one willing to pay the highest price - is placed rightmost, while the least happy consumer - the one barely willing to make the trade - is placed leftmost (at the equilibrium point).
In the graph, it is the area under the demand curve and above the price level, to the left of the equilibrium point, and is shaded blue. (To the left because no trade happens beyond the equilibrium.) At the equilibrium point the consumer is barely happy with the price offered and so there is no consumer surplus.
# Principles of Economics/Allocation
## Scarcity, Allocation, and Markets

There is a scarcity of almost everything that brings people happiness. Economics is the analysis of how a society determines how it will distribute, or allocate, its scarce goods to a population, and to a set of purposes that has an infinite desire for more. This is the first and most fundamental reason why economics is sometimes referred to as "the dismal science": never can all desires be satisfied.
Society accomplishes its allocation through market system or/and command system:
* Market systems use prices as signals to allocate its resources.
* Command systems make use of political choice to allocate its resources.
For our purposes, we shall focus on explaining how market allocation functions.

## Productive and Allocative Efficiency

Through these means, society strives to achieve both productive efficiency and allocative efficiency.
An example of productive inefficiency is when a method of production yields the same as another that uses less of any resource but does not use more of any other resource. Hence, there would be no reason to use the less productive method.
An example of allocative inefficiency is when a method of production uses more of a certain resource and less of another than another method that costs more to society overall. Even if it is productively efficient, the resources are not used in the best distribution -- the allocation is inefficient. In this situation, the inefficient method should be swapped for the more efficient method by a redistribution of which combination of resources is used for a certain mode of production.
Another interpretation of allocative inefficiency is the distribution of goods to members of society in a way that yields less than optimal happiness. This interpretation is almost never achieved but is nevertheless the goal toward which economists strive.
Productive efficiency must be satisfied before allocative efficiency may be.
# Principles of Economics/Budget Constraints
## Budget

This is the basic budget curve (often a line). Its slope is an indication of relative prices (opportunity cost of one good for another) because at any point along the line one has to give up something for more of another. The point indicated by the gray lines is one way of dividing up the budget (in quantity of money terms) between two goods (in quantity terms).

## Budgets at differing incomes

Different incomes will have differing budget constraint positions. Lower incomes will be closer to the origin, while higher incomes are farther. As the graph shows, higher incomes allow one to buy more of one or both goods without necessarily having to give up some of any good.

## Budgets and changing prices

When the price of the good with price along x axis (good Q1 in this case) increases in comparison with the other good, the budget constraint rotates clockwise. This is because the budget can no longer buy as much of the first good (1). When the other good's (2) price increases, the constraint rotates counterclockwise, indicating fewer bought (Q2).

## Increase in cost of good 1

When there is an increase in the cost of good 1, the consequences will be most severe for one who buys all good 1 and no good 2, while it will have no effect on those who buy all good 2, hence the y intersection does not change while the x intersection changes notably. The increase moves the new x intercept closer to the origin, indicating fewer can be bought. A decrease in price would move the new x intercept to the right. If the quantity of good 1 purchased is to remain constant, some of good 2 will be sacrificed, and vice versa.

## Increase in cost of good 2

When there is an increase in the cost of good 2, a similar situation occurs, except that the axes to which the changes act on are changed.
# Principles of Economics/Costs to Firm
## Average fixed cost

The above graph adopts the axes we will be using quite often in economics: quantity on the x and price on the y. Fixed costs for a firm are unchanging but are spread over additional units, resulting in lower average fixed costs.

## Total fixed cost

At any particular production point, we can show the total fixed cost as the pink rectangle. No matter where the gray line is placed, the area of the pink rectangle will be constant. Average is the height at a particular point; total is the area.

## Average and marginal variable cost

The green curve is the marginal cost, the cost of producing an additional unit of a good and includes only variable cost (no fixed cost). This curve starts very high but rapidly falls through increasing returns to scale (increasing productivity), then starts rising as resources become more scarce and costly and/or less suitable. The pink average variable cost curve trails the marginal cost, rising when marginal cost is higher than the average and falling when marginal cost is lower. The average variable cost is flat at the point when it is the same as the marginal cost.

## Individual Supply

The new pink line, average total cost, combines average fixed cost with average variable cost. This leads to the firm's individual supply curve, which is for intents identical to the marginal cost and so also colored green.