OpenLLM-France/wikimedia huggingface dataset:
# The Devonshire Manuscript/Syns loue ys suche that as ye wott

* ←ffull well yt maye be sene || width="200" align="right" | Lo how I seke & sew to haue→
* The Devonshire Manuscript facsimile 51v
* The Devonshire Manuscript facsimile 52r
f. [51v] 1 Synes{es} loue ys suche that as ye wott 2 cannot allways be wysely vsyd 3 I say therfore then blame me nott 4 tho I therin haue ben abusyd 5 ffor as with{w+t+} cause I am accusyd 6 gyllty I graunt suche was my lott 7 & tho yt cannot be excusyd 8 yet let suche folye be forgott 9 ffor in my yeres of Rekles youthe 10 my thought the power of loue so gret 11 that to her lawes I bound my treuthe 12 & to my wyll there was no lett 13 my lyst nomore so far to fett 14 suche frute lo as of loue ensewthe 15 tho gayn was small that was to gett 16 & of the losse the lesse the reuthe 17 And few there ys but fyrst or last 18 a tyme in loue ones{es} shall they haue 19 & glad I am my tyme ys past 20 henceforthe my fredome to with{w+t+}saue 21 now in my hart there shall I grave 22 the groundyd gra{gA}ce that now I tast 23 thankyd be fortune that me gave 24 so fayre a gyfft so sure & fast f. [52r] 25 Now suche as haue me sene or thys 26 whan youthe in me sett forthe hys kynd 27 & foly framd my thought Amys 28 the faute wherof now well I ffynd 29 loo syns that so yt ys assynd 30 that vnto eche A tyme there ys 31 then blame the lott that led my mynd 32 sometyme to lyue in loves blys 33 But frome henceforthe I do protest 34 by pro{p3}ffe of that that I haue past 35 shall neuer cease ceace with{w+t+}in my brest 36 the power of loue so late owt cast 37 the knott therof ys knytt ffull fast 38 & I therto so sure proffest 39 {w+t+}{u'} ffor euermore with me to last 40 the power wherin I am possest ffinis

## Commentary

Attributed to Sir Thomas Wyatt, this poem was entered by H6. This poem opposes the rational detachment from love in maturity to the philandering love of youth.

#### Works Cited

* ↑ R.A. Rebholz, ed. Sir Thomas Wyatt: The Complete Poems. London: Penguin, 1978. 239-40.
# Rail Transport in Las Vegas/Frequently Asked Questions

This is the Frequently Asked Questions page for the Rail Transport in Las Vegas book. Any questions that were asked and answered at the Help Desk will be moved here. Before going to the Help Desk, check here to see if your question has already been answered. Thanks!
If you have a question that you think somebody else might ask, feel free to add the question and the answer here.

## The Wikibook

This section covers aspects of the Wikibook rather than the content of the book itself. Any problem pertaining to the Wikibook will be answered here. To submit proposals, see the Help Desk instead.

## The Content

This section covers any questions regarding the content of the book. This part of the FAQ is sorted by the city, then the specific page (if applicable). If the question is about the Wikibook and not the content of this section, check in The Wikibook instead.

### Primm, NV

Questions pertaining to the tram system in Primm, NV are located here.
The Primm Valley-Whiskey Pete's Tram:
The Primm Valley-Buffalo Bill's Tram:

### Las Vegas, NV

Questions pertaining to the tram system in Las Vegas, NV are located here.
The CityCenter Tram:
The Mandalay Bay-Luxor-Excalibur Tram:
The Mirage-Treasure Island Tram:
The Las Vegas Monorail:

### Miscellaneous

Any questions pertaining to a page not mentioned above will probably be here.
Multimedia Center: If the question does not pertain to the content of the Wikibook, check in The Wikibook instead.
McCarran International Airport Automated People Movers:
UniTrak System:
Fares and Passes:
# Radmind/Radmind Assistant

The Radmind Assistant is a GUI app for Mac OS X.
As of Sept. 2, 2005, here is what is required to get the standard scripts installed with the Radmind Assistant 0.9.6 running under 10.4.x with iHook installed;
1. Issue the command;
sudo defaults write com.apple.loginwindow LogoutHook /etc/logout.hook
to create a link to the iHook logout hook - and if you want login by a 'radmind' local user to trigger a full RADMIND issue the command;
sudo defaults write com.apple.loginwindow LoginHook /etc/login.hook
to create the required links to the iHook login hook.
2. The /etc/radmind.defaults file currently supplied with Radmind Assistant 0.9.6 has 3 bugs...
a) Delete the last line that reads;
'exit 0'
b) Remove the 'switches' from the variables TLSLEVEL and SERVER;
To do this, go to the section labelled "radmind-specific defaults" in /etc/radmind.defaults
Edit the file at this point to read as follows for the first two variables;
TLSLEVEL="`defaults read $ra_domain tlslevel 2>/dev/null || echo ${TLSLEVEL} | awk '{ print $2 }'`"
previously;
TLSLEVEL="-w `defaults read $ra_domain tlslevel 2>/dev/null || echo ${TLSLEVEL} | awk '{ print $2 }'`"
and;
SERVER="`defaults read $ra_domain radmindhost 2>/dev/null || echo ${SERVER} | awk '{ print $2 }'`"
previously;
SERVER="-h `defaults read $ra_domain radmindhost 2>/dev/null || echo ${SERVER} | awk '{ print $2 }'`"
Several users have been confused by the comments at the head of the radmind.defaults file that refers to the fact that any edits to this file don't work if you are using the Radmind Assistant unless some 'defaults' setting is changed'. I don't think there has been full information provided on exactly what this means, especially as it doesn't seem to preclude things working.
Also - I originally tried getting things to work by changing the other references at the head of the file from AUTHLEVEL to TLSLEVEL, but in the end I changed them back again and it still worked.
# Radmind/Tripwire

The open source tool called Tripwire is a host-based intrusion detection system. It is not so much concerned with detecting intrusion attempts at the periphery of a computing system (as in Network intrusion detection systems), but rather looks for and reports on the resultant changes of state in the computing system under observation.
Intruders usually leave traces of their activities (change system state). Tripwire looks for these by monitoring key attributes of files that should not change, including binary signature, size, expected change of size, etc. - and reporting its findings. While useful for intrusion detection it can also be used for many other purposes such as integrity assurance, change management, policy compliance, and more.
Many techniques used for host-based intrusion detection were entirely or in part pioneered by Tripwire. In many senses recent efforts at managing security on computers, such as the Trusted Computing Group Trusted Platform Module are extensions of these ideas and techniques wrapped up in a piece of silicon that runs external to the CPU and is thus harder to crack.
Radmind goes beyond the general Tripwire by allowing you to reverse changes instead of only notifying the administrator. To fail tripwire means that something changed without the administrator's knowledge.
# Radmind
## radmind

    A suite of Unix command-line tools and a server designed to remotely administer the file systems of multiple Unix machines. For Mac OS X, there's also a graphical interface.
Find it at: http://www.radmind.org
Find more documentation at: http://radmind.org/documentation.html

## Table of Contents

* What is a Tripwire?
* ktcheck
* fsdiff
* lapply
* lcreate
* iHook
* Radmind Assistant
# Radmind/ktcheck

NAME
SYNOPSIS
DESCRIPTION
OPTIONS
FILES
EXIT STATUS
SEE ALSO
# Rail Transport in Las Vegas/Help Desk

Welcome to the Help Desk for the Rail Transport in Las Vegas Wikibook! This page is designed for questions regarding the book.
Important: Before submitting a question, check the Frequently Asked Questions to see if the question has already been answered.
If you are sure that the question isn't on the FAQ, feel free to ask it below this text. Use the "*Bullet Point" to style your question. It will turn out like this:
If you think you know the answer to a question, do not hesitate to answer it! Style your answers with the ":Answer" to indent your answer so that it looks like this:
    Answer
Ask your question under the correct topic, please. As of now, the Help Desk is managed by Pkkao. If your question isn't answered soon enough, ask it here.

## The Wikibook

This section covers aspects of the Wikibook rather than the content of the book itself. Any problem pertaining to the Wikibook will be answered here. Proposals can be submitted here.

## The Content

Please ask any questions regarding the actual content of the book here. This part of the FAQ is sorted by the city, then the specific page (if applicable). If the question is about the Wikibook and not the content of this section, check in The Wikibook instead.

### Primm, NV

Please ask questions pertaining to the tram system in Primm, NV here.
The Primm Valley-Whiskey Pete's Tram:
The Primm Valley-Buffalo Bill's Tram:

### Las Vegas, NV

Please ask questions pertaining to the tram system in Las Vegas, NV here.
The CityCenter Tram:
The Mandalay Bay-Luxor-Excalibur Tram:
The Mirage-Treasure Island Tram:
The Las Vegas Monorail:

### Miscellaneous

Please ask any questions pertaining to a page not mentioned above here.
Multimedia Center: If the question does not pertain to the content of the Wikibook, check in The Wikibook instead.
McCarran International Airport Automated People Movers:
UniTrak System:
Fares and Passes:
# DESCRIPTION:

Returns TRUE for port values.
PORT? is an action value.

# ARGUMENTS:

* value -- (Type: any-type)
# DESCRIPTION:

Returns TRUE if the value is positive.
POSITIVE? is an action value.

# ARGUMENTS:

* number -- (Type: number char money time)
# DESCRIPTION:

Outputs a value with no line break.
PRIN is a native value.

# ARGUMENTS:

* value -- The value to print (Type: any)
# DESCRIPTION:

Protect a word or block to prevent from being modified.
PROTECT is a native value.

# ARGUMENTS:

* value -- The word or block of words to be protected (Type: word block)
# DESCRIPTION:

Prints a molded, unevaluated value and returns the same value.
PROBE is a function value.

# ARGUMENTS:

* value -- (Type: any)
# Rebol Programming/purple

PURPLE is a tuple of value: 128.0.128
# DESCRIPTION:

Changes a value at the given index. (See manual)
POKE is an action value.

# ARGUMENTS:

* value -- (Type: series money date time object port tuple)
* index -- (Type: number logic pair)
* data -- new value (Type: any)
# DESCRIPTION:

Returns the first number raised to the second number.
POWER is an action value.

# ARGUMENTS:

* number -- (Type: number)
* exponent -- (Type: number)
# DESCRIPTION:

Outputs a value followed by a line break.
PRINT is a native value.

# ARGUMENTS:

* value -- The value to print (Type: any)
# DESCRIPTION:

Protects all system functions and the system object from redefinition.
PROTECT-SYSTEM is a function value.
# Structural Biochemistry/Pinocytosis

In pinocytosis, the cell “gulps” droplets of extracellular fluid into tiny vesicles. It is not the fluid itself that is needed by the cell, but the molecules dissolved in the droplets. Because any and all included solutes are taken into the cell, pinocytosis is nonspecific in the substances it transports. In contrast to phagocytosis referring to "cell-eating", pinocytosis refers to "cell drinking". The hydrolysis of food inside vacuoles, called intracellular digestion, begins after a cell engulfs solid food by phagocytosis or liquid food by pinocytosis. In the process of pinocytosis, the plasma membrane forms an invagination and any substance found within the area of invagination is then brought into the cell. Generally, this material will be dissolved in water and thus this process is also referred to as "cell drinking" to indicate that liquids and material dissolved in liquids are ingested by the cell. This is opposed to the ingestion of large particulate material like bacteria or other cells or cell debris.
In essence, pinocytosis adsorbs extracellular fluids for the nutrients and material broken down in the fluid. This process is takes energy in the form of adenosine triphosphate. It is also a method of ingestion that is less selective than phagocytosis. It is less selective in that it basically just adsorbs all fluid in its immediate environment. Basically, pinocytosis is unspecific to what it transports, while phagocytosis is careful in choosing food particles to engulf.
# Structural Biochemistry/Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase

Cellular homeostasis requires balance between phosphorylation catalyzed by protein kinases and dephosphorylation catalyzed by protein phosphatases. Deregulation of this balance leads to pathphysiological states that drive diseases such as cancer, heart disease, and diabetes. The discovery of PHLPP, which stands for Pleckstrin Homology Domain Leucine-Rich Repeat Protein Phosphatase, contributes to the cast of phosphate-controlling enzymes in cell signaling. PHLPP isozymes catalyze the dephosphorylation of a conserved regulatory motif, the hydrophobic motif, on the AGC kinases Akt, PKC, and S6 kinase to inhibit cellular proliferation and induce apoptosis.
The frequent deletion of PHLPP in cancer, coupled with development of prostate tumors in mice lacking PHLPP1 identifies PHLPP as an important tumor suppressor. It dephosphorylates a key regulatory site on the C terminus of Akt, the hydrophobic motif, therefore inactivating the kinase.
PHLPP plays an important role in disease. It not only blocks tumorigenesis by inactivation of oncogenic pathways, but also sensitizes cancer cells to chemotherapy. With the loss of PHLPP1, this causes prostate tumors in mice and its genetic deletion or mRNA repression is prevalent in prostate cancer patients.
Reference: Noel A. Warfeland Alexandra Newton from Departments of Pharmacology and Chemistry and Biochemistry, University of California, San Diego
# Structural Biochemistry/Phosphofructokinase-1
## Overview

Phosphofructokinase-1 (PFK-1) is a major factor in process known as glycolysis. PFK-1 catalyzes the committed step, or begins an irreversible enzymatic reaction, which is the point of no return. PFK-1 also regulates triacylglycerol synthesis, which helps decrease the amount of fat storage. By preventing PFK-1 from doing its job, other glycolytic intermediaries decrease such as 2,3-bisphosphoglycerate.

## Defective Phosphofructokinase-1

Faulty PFK-1 can cause a build up of glucose, glucose-6-phosphate, and other glycolytic intermediaries. The end result of this is glycogen synthesis, which can lead to increased solute concentration in red blood cells, enlarged spleen, a swelled heart, and ultimately death.

## References

1. "Phosphofructokinase-1." Phosphofructokinase-1. N.p., n.d. Web. 07 Dec. 2012.
# Structural Biochemistry/Pili

Pili--plural for pilus--are hairlike appendages found on the surface of many bacteria. Pili are fragile and need to be constantly replaced. The pili (plural) or pilus (singular)is a biological molecule that is on the surface of many bacteria. It is sometimes described as a hair structure. The term pilus comes from the latin word thread or fiber. All of the pili are made up of oligomeric proteins. The pili is used for different purposes in the cell. It is attached on the surface of cells in order to transfer DNA from cell to cell, attach to surfaces and for general cell-cell adhesion. There are two different kinds of Pili. Short and long. The short is very plentiful around the cell and help the cells colonize environmental surfaces and stick to other cells. This also helps the cells resist potential flushing! The long pili have to do with sex or transfering DNA. This is called the conjugation pili because it helps with conjugation or sex. Conjugation is how a cell transfers DNA to another by contact with the cell. Pili also have implications with bacterial infection. The pili help the bacteria not get flushed by adhesion, and therefore stick to cells and infect. This causes illness due to pili helping bacteria bind to cells.

## Types
### Conjugative pili

During the process of bacterial conjugation, conjugative pili allow the transfer of DNA between bacteria. They are sometimes called "sex pili", in reference to sexual reproduction, because they allow for the exchange of genes via the formation of "mating pairs".

### Type IV pili

Type IV pili, generate motile forces. The external ends of the pili adhere to a solid substrate--either the surface to which the bacteria are attached or to other bacteria--and when the pilus contracts, it pulls the bacteria forward, like a grappling hook. Movement produced by type IV pili is typically jerky, but can be a gliding motion as well.

## Fimbraie

Attachment of bacteria to host surfaces is required for colonization during infection or to initiate formation of a biofilm. A fimbria is a short pilus that is used to attach the bacterium to a surface. Fimbriae are either located at the poles of a cell, or are evenly spread over its entire surface. Mutant bacteria that lack fimbriae cannot adhere to their usual target surfaces and, thus, cannot cause diseases.

## References

http://www.daviddarling.info/encyclopedia/P/pilus.html
* ↑ Pilus, November 14th, 2012.
# Structural Biochemistry/Phosphatase PHLPP

The life cycle of protein kinase C is regulated by multiple phosphorylation as well as dephosphorylation. The maturation of protein kinase C involves three ordered phosphorylations. These phosphorylations are: 1) One at the activation loop, 2) COOH-terminal sites, but two of them. These processes lead to a signaling-competent enzyme. The process of dephosphorylation results in protein degradation.
Recent discoveries have illustrated a new family of protein phosphatases called PHLPP, which stands for “PH domain leucine-rich repeat protein phosphatase”. PHLPP terminates Protein Kinase B signaling through dephosphorylation of the hydrophobic motif on Protein Kinase B also known as Akt.
There are two isoforms of PHLPP called PHLPP1 and PHLPP2, which dephosphorylate the hydrophobic motif on PKC BII. This process brings Protein Kinase C to the detergent-insoluble fraction, which effectively terminates its life cycle.
Deletion mutagenesis elucidates the idea that PH domain is vital for the effective dephosphorylation of PKC BII by PHLPP in cells. However, for the PDZ-binding motif, which is necessary for Akt regulation, it is dispensable.
The depletion of PHLPP in colon cancer and normal breast epithelial cells results in an increase in conventional and novel PKC levels, revealing that PHLPP regulates the cellular levels of PKC by specifically dephosphorylating the hydrophobic motif. This also causes the destabilization of the enzyme, which promotes its degradation.
Protein phosphorylation acts as one of the most significant regulatory mechanisms in cell signaling. Vital cellular decisions such as death or survival and proliferation or differentiation are made depending on the phosphorylation state of the signaling molecules. Therefore, precise control of the balance between phosphorylation and dephosphorylation is crucial for living organisms to maintain normal physiological functions. The disturbance of regulation of the signaling pathways, which results in disturbing a sense of equilibrium leads to the development of diseases such as cancer and diabetes. This leads to a pathogenic state in which both kinases and phosphatase are identified as oncogenes or tumor suppressors.
References: The Phosphatase PHLPP Controls the Cellular Levels of Protein Kinase C; By: Tianyan Gao, John Brognard, and Alexandra Newton from the Department of Pharmacology and the Biomedical Sciences Graduate Program, University of California, San Diego
# Structural Biochemistry/Pheromones
## Overview

Pheromones are a type of hormones that act outside of the body, otherwise known as ectohormones. Pheromones are chemicals that animals and insects produce that affect the behavior of another animal or insect of the similar species. Pheromones are used to trigger a wide range of behaviors that are not limited to but include alarming for danger, sexual arousal, marking a territory, and leaving a trail.

## Types of Pheromones

1. Releaser Pheromones These types of pheromones illicit an immediate response that is usually related to sexual attraction.
2. Primer Pheromones These illicit slower responses and are involved in a variety of activities such as influencing development and altering hormone levels.
3. Signaler Pheromones These are what give a odor imprint allowing an individual to be recognized, usually by the mother.
4. Modulator Pheromones These are usually found in sweat and either alter or synchronize bodily functions.

## References

Nordqvist, Christian. "What are Pheromones? Do Humans Have Pheromones?." Medical News Today. Medical News Today, 11 Aug. 2011. Web. 20 Nov. 2012. <http://www.medicalnewstoday.com/articles/232635.php>.
# Solitaire card games/Double or Quits

This game is so called because the cards are built in a pattern where the value doubles and decreases by 13 if necessary.
The game starts with eight cards dealt in a 3x3 grid with a hollow center. The middle card of the bottom row becomes the foundation and all other cards form the reserve. The illustration below shows the layout:
| R | R | R |
| R | | R |
| R | F | R |
(F is for the foundation and R are for the reserves) :
The foundation is built regardless of suit using a sequence in which the value doubles: A-2-4-8-3-6-Q-J-9-5-10-7-A-2, etc. For instance, if the card on the foundation is a 4, an 8 should be placed over it. Cards in the reserve are available for play and any gaps on the reserve are immediately filled by cards from the wastepile, or from the stock in case the wastepile is empty.
If play is not possible from the reserve, the cards from the stock are dealt one at a time into the wastepile. When the stock runs out, the wastepile is picked up and becomes the new stock. This can be done only twice in the game.
One can notice that kings are not involved in the sequence above. The prevalent rule set states that the kings are left in the deck and when a king ends up in the reserve, it stays there. Furthermore, in the beginning of the game, if any king appears in the tableau, it is removed and placed at the bottom of the deck and another card is placed on it.
The game is won when all 48 cards are put in the foundation, with the kings end up in the reserve.
The sequence above is formed as follows: Let 1=A, 11=J, 12=Q
$A*2=2$ $2*2=4$ $4*2=8$ $8*2=16;16-13=3$ $3*2=6$ $6*2=12=Q$ $Q*2=24;24-13=11=J$ $J*2=22;22-13=9$ $9*2=18;18-13=5$ $5*2=10$ $10*2=20;20-13=7$ $7*2=14;14-13=1=A$
# Solitaire card games/Elevens Up

The aim is to remove pairs of cards that add up to 11.

## Rules

Remove any 2 or more exposed cards that add up to 11. The face cards have been replaced with extra aces with a value of 1.
Here is an example: 4♦ + 3♠ + 2♣ + 1♣ + 1♦= 11
The Deck turns up 1 card at a time. If the first card cannot be used, it will be moved to the second Dealt Pile when you deal the next card. If the card in the second Dealt Pile cannot be used, it will replace empty spaces on the tableau. If there are no spaces available in the Tableau, the card will be discarded to the Waste Pile.
When there is no more cards in the Deck and you are unable to remove any cards, the game is finished.
The game is won when the entire tableau has been removed.

## Scoring

Each card removed earns points. Point values are determined by where the cards are located. There are many variations of scoring. Here are a couple:
1.
– Dealt Pile = 20 points
– Level 1 = 100 points
– Level 2 = 200 points
– Level 3 = 300 points
– Level 4 = 400 points
– Level 5 (top level) = 800 points
– The first time any of the 3 peak cards are removed, a bonus is rewarded.
– 100 extra points are given for each card left unused in the Stock Pile.
2.
- Dealt Piles: 100 points
- Level 1: 200 points
- Level 2: 300 points
- Level 3: 400 points
- Level 4: 500 points
- Level 5: 800 points
- For removing the entire tableau (excluding the extra fields), you receive an additional 10,000 points.

## Alternative Names

* Ace Solitaire
* +11 Solitaire