OpenLLM-France/wikimedia huggingface dataset:
# Radiation Oncology/Neutrons

* Front Page: Radiation Oncology | RTOG Trials | Randomized Trials
Neutron Therapy

## By Disease Site

* General Head & Neck
* Salivary Glands

## Overview

* Initial use of neutrons for clinical treatment occurred 1936-1943, but resulted in significant late effects
* By 1960's, radiobiology of neutrons was better understood, and a cyclotron was constructed at the Hammersmith Hospital in London. In USA, physics-lab based devices were used for initial pilot trials.
* In 1984, University of Washington commissioned a high-energy neutron generator for clinical beam delivery, with NCI funding
* Neutrons can be delivered via several modalities
** External beam neutron therapy
** Boron-neutron capture therapy (BNCT)
** Neutron brachytherapy via Californium-252
* Most clinical trials were inconclusive, and enthusiasm about neutrons as a treatment modality waned

## Boron Neutron Capture Therapy (BNCT)

* FBPA (4-borono-2-(18) F-fluoro-phenylalanin) PET imaging
** Kohei Hanaoka et al. EJNMMI Res. 2014. FBPA PET in boron neutron capture therapy for cancer: prediction of (10)B concentration in the tumor and normal tissue in a rat xenograft model (PMID: 25621196)
** L Menichetti et al. Appl Radiat Isot. 2009 Jul. Positron emission tomography and [18F]BPA: a perspective application to assess tumour extraction of boron in BNCT (PMID: 19410471)
* Accelerator-Based BNCT (AB-BNCT) vs. Reactor-Based BNCT (RB-BNCT)
** Minoru Suzuki et al. Radiother Oncol. 2009 Jul. Impact of accelerator-based boron neutron capture therapy (AB-BNCT) on the treatment of multiple liver tumors and malignant pleural mesothelioma (PMID: 19329206)
* Tsing Hua open-pool reactor (THOR)
** C J Tung et al. Appl Radiat Isot. 2004 Nov. Characteristics of the new THOR epithermal neutron beam for BNCT (PMID: 15308158)
** Ling-Wei Wang et al. Cancer Commun (Lond). 2018. Clinical trials for treating recurrent head and neck cancer with boron neutron capture therapy using the Tsing-Hua Open Pool Reactor (PMID: 29914577)
* Proton Accelerator based Boron Neutron Capture Therapy (A-BNCT) facility in Korea
** Eunjoong Lee et al. Appl Radiat Isot. 2018 Dec. Radiation safety analysis for the A-BNCT facility in Korea (PMID: 30273764)
* Boron neutron capture therapy (BNCT) in Finland
** Sauli Savolainen et al. Phys Med. 2013 May. Boron neutron capture therapy (BNCT) in Finland: technological and physical prospects after 20 years of experiences (PMID: 22613369)
* Treatment Planning System
** Tzung-Yi Lin et al. Development and verification of THORplan--a BNCT treatment planning system for THOR. Appl Radiat Isot. 2011 Dec;69(12):1878-81. (PMID: 21497101)
** Naonori Hu et al. Evaluation of a treatment planning system developed for clinical boron neutron capture therapy and validation against an independent Monte Carlo dose calculation system. Radiat Oncol. 2021 Dec 24;16(1):243. (PMID: 34952608)
# Radiation Oncology/Ovary

* Front Page: Radiation Oncology | RTOG Trials | Randomized Trials
Ovarian Tumors
* Official Guidelines
* Staging
* Overview
* Benign Ovarian Masses
* Epithelial Ovarian Cancer
* Sex cord-stromal tumors
** Granulosa Cell Tumor
# Radiation Oncology/Oncovirus

* An oncovirus is a virus that can cause cancer
* This term originated from studies of acutely transforming retroviruses in the 1950–60s, when the term "oncornaviruses" was used to denote their RNA virus origin
* With the letters "RNA" removed, it now refers to any virus with a DNA or RNA genome causing cancer and is synonymous with "tumor virus" or "cancer virus"
* The vast majority of human and animal viruses do not cause cancer, probably because of longstanding co-evolution between the virus and its host
* Oncoviruses have been important not only in epidemiology, but also in investigations of cell cycle control mechanisms such as the retinoblastoma protein
# Radiation Oncology/Neuroendocrine/Overview

Neuroendocrine Overview

## Background

Pathology:
* NANETS
** 2010 PMID 20664470 Full text -- "The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems." (Klimstra DS, Pancreas. 2010 Aug;39(6):707-12.)

## Official Guidelines

* NANETS Website - North American Neuroendocrine Tumor Society
** Diagnosis:
*** 2010 PMID 20664471 Full text -- "NANETS consensus guidelines for the diagnosis of neuroendocrine tumor." (Vinik AI, Pancreas. 2010 Aug;39(6):713-34.)
** Treatment: Stomach and pancreas
*** 2010 PMID 20664472 Full text -- "NANETS treatment guidelines: well-differentiated neuroendocrine tumors of the stomach and pancreas."
** Treatment: Jejunum, Ileum, Appendix, and Cecum
*** 2010 PMID 20664473 Full text -- "The NANETS consensus guideline for the diagnosis and management of neuroendocrine tumors: well-differentiated neuroendocrine tumors of the Jejunum, Ileum, Appendix, and Cecum."
** Treatment: Distal colon and rectum
*** 2010 PMID 20664474 Full text -- "The NANETS consensus guidelines for the diagnosis and management of gastrointestinal neuroendocrine tumors (nets): well-differentiated nets of the distal colon and rectum."
** Treatment: Pheochromocytoma, paraganglioma, medullary thyroid cancer
*** 2010 PMID 20664475 Full text -- "The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: pheochromocytoma, paraganglioma, and medullary thyroid cancer."
** Treatment: Thorax (lung and thymus)
*** 2010 PMID 20664476 Full text -- "NANETS consensus guideline for the diagnosis and management of neuroendocrine tumors: well-differentiated neuroendocrine tumors of the thorax (includes lung and thymus)."
** Treatment: High grade extrapulmonary
*** 2010 PMID 20664477 Full text -- "The NANETS consensus guidelines for the diagnosis and management of poorly differentiated (high-grade) extrapulmonary neuroendocrine carcinomas." (Strosberg JR, Pancreas. 2010 Aug;39(6):799-800.)
# The Azure Guide/Speech services

In this section, we take a look at another of Azure's services: speech and text recognition.

## Introduction

It is a family of tools which enable developers to quickly and easily add speech and text (both ways) functionalities to their applications (which can be in various platforms). It also works online, and hence there is no need to pack anything with the program.
Unlike Compute Vision, this one does have a free tier, but it is significantly restricted in terms on the volume that can be processed. It is usually a better idea to use the paid tier for all but the most simple applications. Additionally, there is a dedicated 30-day trial which might be a better option.

## Usage

   Speech-to-text from Azure Speech Services, also known as speech-to-text, enables real-time transcription of audio streams into text that your applications, tools, or devices can consume, display, and take action on as command input. This service is powered by the same recognition technology that Microsoft uses for Cortana and Office products, and works seamlessly with the translation and text-to-speech.
   – https://docs.microsoft.com/en-us/azure/cognitive-services/speech-service/speech-to-text
It depends on the language used. For example, for Java projects, you need to use Maven. It is recommended that you study the sample code and use that as a starting point to integrate in your final application. Note that there is no sample code available for Java when it comes for Text to Speech, so you'll have to try to understand it from the C# or Python code provided.
Remember that you'll need to get the Speech API key first from the Azure portal (portal.azure.com) and create Speech API keys to use for your application.
If you are previously using Bing Speech or Custom Speech Service, you'll need to migrate to Azure's Speech services.

## References

* ↑ https://azure.microsoft.com/en-us/pricing/details/cognitive-services/speech-services/
* ↑ https://docs.microsoft.com/en-us/azure/cognitive-services/speech-service/get-started
* ↑ https://docs.microsoft.com/en-in/azure/cognitive-services/speech-service/quickstart-java-jre
* ↑ https://docs.microsoft.com/en-us/azure/cognitive-services/speech-service/rest-text-to-speech
* ↑ https://docs.microsoft.com/en-in/azure/cognitive-services/speech-service/how-to-migrate-from-bing-speech
* ↑ https://docs.microsoft.com/en-in/azure/cognitive-services/speech-service/how-to-migrate-from-custom-speech-service
# The Bell Jar/Eleven
## Plot summary

The chapter begins with Esther sitting in Doctor Gordon's beige-coloured office where she is to be examined for the first time. He asks her about the issues she's been having, and at the end of the session he sets up another appointment the following week. Esther expresses her immediate dislike for him for various reasons, ranging from the way his family picture stands to how he doesn't tell Esther the diagnosis that would make her immediately feel better.
The next time we see Esther is on a date with a random, unnamed young Navy sailor on the town Common. She pretends to be an orphan Elly Higginbottom, creating a fictional history for herself to make the sailor pity her.
We then learn that Doctor Gordon recommended to Mrs Greenwood that Esther undergo shock therapy at his private hospital. We see Esther in a park, reading a tabloid, the only thing she can now read, being very interested in suicide and murder stories that are published in such newspapers. She imagines what it would be like to commit Seppuku and decides that it must take a lot of courage.
Esther and her mother are driven to Doctor Gordon's hospital by Dodo Conway. On the way there, Esther tells the story of when she tried escaping to Chicago by bus, but only managed to go two blocks away from her house.

## Example study questions

* Is Esther's judgement of Dr Gordon justified? Why? Why not?
# The Bell Jar

This book is intended to provide help for students studying the novel "The Bell Jar" by Sylvia Plath, as well as create a framework for further analysis of particular chapters, characters or themes from the book.

### Overview

The Bell Jar by Sylvia Plath is a novel with a troubled publishing history. It is the only book by Plath, written under the pseudonym Victoria Lucas around 1961. At first, publishing companies rejected the unknown author, even the company that published Plath’s poetry. The book was first published in 1963. It received moderate praise, reasonable sales and was eventually forgotten. Only three years later, after Plath’s death, the book was published again, this time with her real name on the cover. This surprised everybody, publishers and editors included, making them fight each other for publishing rights, seeing as Plath’s works were very marketable after her shocking death. This revelation also allowed for more in-depth readings of The Bell Jar through the perspective of Plath’s life. The book is at the very least semi-autobiographical, incorporating many aspects of Plath’s life into a fictional environment.
The plot follows Esther Greenwood, a young woman on the brink of adulthood. The story of Esther is a story about dealing with depression, but also about dealing with the choices a young person faces in their life. Esther, finishing her studies in Massachusetts, seems to have her life under control, but after her experiences in New York during an internship she finds herself lost and incapable of making any decision regarding her future. She should be having the time of her life, with a bright future ahead of her. However, she finds herself powerless and idle, and she cannot find a reason why
* Characters

### Chapters

* One
* Two
* Three
* Four
* Five
* Six
* Seven
* Eight
* Nine
* Ten
* Eleven
* Twelve
* Thirteen
* Fourteen
* Fifteen
* Sixteen
* Seventeen
* Eighteen
* Nineteen
* Twenty
# The Bell Jar/Eight
## Plot summary

Chapter eight tells the story of Esther's visit to Buddy's TB sanatorium in the Adirondacks. She was driven there the day after Christmas by Mr Willard. During their drive, he tells Esther that he would love to be able to call her his daughter. At the brown-coloured sanatorium they meet Buddy. Esther is surprised to see him fat, having put on weight due to lot of food and little exercise. They go to Buddy's room, at which point Mr Willard leaves them, assuming Esther would want to say a couple of days before returning on a train. After a short talk, Buddy proposes to Esther to very little reaction. She rejects him, saying she had decided to never marry. She reminds Buddy of when he called her a neurotic for wanting to live in two places at once. She laughs at him scornfully, saying that she'll live between two mutually exclusive things for the rest of her life.
The narrative skips forward to later on during her stay, when Buddy tries to teach Esther how to ski, despite himself knowing only the theory. It goes well at first, but then Esther accidentally takes the rope tow to the top of the hill and, despite her doubts, takes off going straight down. She comes speeding down the slope and crashes, breaking her leg in two places. The chapter ends on Buddy pronouncing this diagnosis.

## Example study questions

* What do you think about Esther's reaction to Buddy's proposal?
# The Azure Guide/Introduction

Here, we present a brief overview on what Azure is all about.

## Introduction

Azure is most well known for its cloud services - it powers Office 365 to start with, and also offers a host of virtual machine facilities that can be run on the cloud. But it also offers a variety of other features, for example,
* AI and machine learning
* Speech and text recognition
* Databases (SQL and Azure Databricks)
* Web services
* Active Directory (AD) services
and so on.

## Usage

There are a wide variety of reasons as to why someone might want to use Azure. Consider the following scenarios:
* A user wants to run a task which requires high computational power. Instead of having to upgrade what they have, they can easily create an Azure VM to be used for that period of time. When the task is done, the VM can be quickly deleted.
* Applications requiring Windows Server 2008 or 2008 R2 at Azure will benefit from the former's free extended security updates under it.
* Azure Virtual Desktop is a compelling option for applications which require Windows 7 (due to the same reason as mentioned above).
* A user wants to use speech or text functionality within their application. They can easily make use of Azure's speech SDKs, and as they are online, do not need to be packed within the application.

## Access

Azure is generally not free, with most services being provided through a subscription or as a PAYG (Pay as you Go) model. However, there are several ways for users to use Azure services for free:
* Azure for Students - Gives $100 of credit that can be used for a year; only students are eligible for this promotion, however.
* Azure Free - provides $200 of credit for a year. However, a credit card is required.
Note that the Azure name can be used even in cases where there is no direct relevance: Azure Dev tools for teaching being an example. Formerly called Imagine Standard/Premium, while it is a very useful program which provides free access to valuable tools like Visual Studio and Windows 10, it does not provide Azure credit by itself.

## External tutorials

See External links.
# The Bell Jar/Eighteen
## Plot summary

Esther wakes up after the electroshock procedure to the voice of Doctor Nolan. She is taken outside and wonders at how at peace she feels. The doctor reassures her that the procedures will always be like that.
At dinner, Esther examines the knife she is using to eat and wonders why she used to like knives before putting it down on the table. She watches Joan and another girl play the piano, and comments how with her looks, Joan probably couldn't even keep a boy like Buddy Willard.
The narration skips forward. After her shock treatments had ended, Esther is doing well and has town privileges. Joan, whose privileges had been revoked, visits Esther in her room to boast about getting a letter. We are not told who it's from, but from the conversation we understand that it's from Buddy Willard and, as she shows Joan, Esther also got one. They discuss their relationships with Buddy and Joan admits that she never liked him much, but really liked Mr. and Mrs. Willard. She says how she liked how happy they were, unlike Joan's actual parents. Esther wonders whether letting Buddy visit and telling him that she didn't want to be with him would be an important step in her recovery. Joan says that she would invite Buddy so that he brings his mother with him. Esther has trouble picturing Joan and Mrs. Willard together.
Later on Esther and Joan continue their conversation. Joan mentions how she never liked Buddy because of how he had always pretended to know everything about women. She confesses that she likes Esther, and it is strongly implied that Joan is sexually interested in her. Esther is repulsed by Joan and remembers a story about two girls that were discovered together in her college dormitory. She tells her that Joan makes her puke and leaves the room.
The next time we see Esther is in a clinic waiting room, waiting to get a fitting for female contraceptive. She was encouraged to do so by Doctor Nolan and uses Philomena Guinea's money to “buy herself freedom”. She is confounded by how easy it is for other women to have babies and contemplates her own lack of maternal instinct as she watches mothers and their babies sitting in the waiting room. Coming back from the clinic, Esther calls herself “her own woman” and decides that she now has to find a proper sort of man.

## Example study questions

* Comment on the narrative gaps used in the book on the basis of the conversation between Esther and Joan. Are there any other examples like that in the book?
* Comment on the relationship between Joan and Esther. How does it change as time progresses and why?
* Comment on Esther's remark about other women wanting to shape her. In the light of the whole novel, how does Esther shape herself?
# The Dark Is Rising Sequence: A Reader's Guide

The Dark Is Rising Sequence is a series of 5 books written by Susan Cooper, aimed at young readers. The books are set in late 20th century England and Wales, but refer to British history. The purpose of this book is to provide background information for the history and geography of the books.

## Strategy

To get started, a list of terms and characters can be created.
* Non fictional terms can be expanded upon using imports from wikipedia, which can then be modified to fit into this book
* Character descriptions, plot summaries, and fictional terms can be compiled following the style of the Muggles' Guide to Harry Potter.

## Audience

This book should be addressed to young readers (perhaps ages 11 and up), for use as a personal study guide or as a classroom teacher's guide.

## Books
### Over Sea, Under Stone

Three children find a map, and go in search of the treasure it leads to. However, they are soon drawn into the long battle between the Dark and the Light.

### The Dark is Rising

Will Stanton turns 11 years old, and learns of his true nature as an Old One.

### Greenwitch

The Drews return to Cornwall just in time for the annual ceremony of the Greenwitch.

### The Grey King

After a terrible illness, Will Stanton is sent to stay with relatives in Wales to regain his strength. Instead, his time in Wales becomes one of his greatest challenges.

### Silver on the Tree

The Drews, Will, Bran and Merriman come together for the battle to end all battles between Light and Dark

## Characters

* Barney Drew
* Jane Drew
* Simon Drew
* Merriman Lyon
* Will Stanton
* Bran Davies
* Rufus The Dog

## Geography

* Cornwall
* Wales
* Thames (the river)

## History

* Saxons
* Danes
* King Arthur
* Merlin
* The London Blitz
# The Descent of Man

This book is a summary of The Descent of Man published by Charles Darwin in 1871.

## Introduction

In his introduction to The Descent of Man, Darwin states that he wrote this book because of the wide acceptance the concept of natural selection had received following the publication of The Origin of Species. He states a three-fold object for writing The Descent of Man, first of all to consider whether man "descended from a pre-existing form; secondly, the manner of his development; and thirdly, the value of the differences between the so-called races of man."
Darwin mentions three authors who had written about "the high antiquity of man", i.e., Boucher de Perthes, Sir Charles Lyell, and Sir John Lubbock. He also states that he will not be making a detailed comparison between man and apes because of the work others had already done in that area, and he mentions the work of Prof. Thomas Henry Huxley who had "conclusively shown that in every visible characteristic man differs less from the higher apes" than the apes differ from other primates.
Furthermore, Darwin mentions others including Lamarck, Wallace, Vogt, Buchner, Rolle, and Haeckel in addition to the four already mentioned who had concluded that man had descended with other species from a common, ancient and extinct ancestor. He even mentions the titles of the works of the less well-known German authors, his point being that what he had to say in The Descent of Man was not entirely new.

## Contents

* Chapter I: The Evidence of the Descent of Man from some Lower Form
* Chapter II: On the Manner of Development of Man from some Lower Form
* Chapter III: Comparison of the Mental Power of Man and Lower Animals
* Chapter IV: Comparison of the Mental Powers of Man and the Lower Animals -continued
* Chapter V: On the Development of the Intellectual and Moral Faculties
* Chapter VI: On the Affinities and Genealogy of Man
* Chapter VII: On the Races of Man
# The Conran Community/Preface & Acknowledgements

This book has been in the minds of many 'Conran people' for many years. It cannot be a definitive or exhaustive account of the Conran Community. Nor can it capture a single true version of this history: there are bound to be natural subjective variations in recalling events and 'facts'. What we can do here, is collect, preserve and share this indelible and unique period of so many people's lives.
Where possible, we draw on historically rigorous sources, though these are sparse. However, these would only reveal a small sliver of the picture, bereft of all the subjective, rich, unreliable memories and stories needed to describe something of the essence of this era.
The main focus of this book is on a few decades that seem short in retrospect, but which seemed much longer living through them. Like many others, I developed a profound attachment to the place from early childhood, spending my first two dozen summers there, and as much time in between as possible. Most of my dreams continue to be located in or around Conran, perhaps an indication that most people can also have a soul-deep connection to place.
I know I'm not alone in still feeling the deep loss of this place that was home for many formative years. Annual cycles of spiritual replenishment became permanently integrated into our personal and collective consciousness.
Little seems to be known, or at least documented about the original custodians of the Conran area. The authors acknowledge that the Conran Community occupied land that had been cared for by the Ganaikurnai and Bidawal nations who were traditional custodians for at least 10,000 years.
# The Conran Community

This book is part of a collaborative social history project. It aims to document what is known about the Cape Conran Community that emerged in the mid-1900's at East Cape Conran in far-eastern Victoria, Australia. Content may range from:
* Aboriginal and white history before any structures were built (likely to be sparse)
* The establishment of the houses after World War II
* Stories from the period of their occupancy
* Their forced demolition in 1986 and the disbandment of the Community
* The legacy and remains of the Community through to the present.
Proposed Draft Contents