# 2022 Zagreb Open – Singles

Sebastián Báez was the defending champion but chose not to defend his title.
Filip Misolic won the title after defeating Mili Poljičak 6–3, 7–6$^{(8–6)}$ in the final.

## Seeds

* Jordan Thompson (first round)
* Aleksandar Vukic (first round)
* Christopher O'Connell (first round)
* Damir Džumhur (withdrew)
* Vít Kopřiva (second round)
* Jason Kubler (semifinals)
* Juan Pablo Ficovich (first round)
* Federico Gaio (second round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| 6 | Jason Kubler | 5 | 6 | 3 | | | | |
| Q | Filip Misolic | 7 | 3 | 6 | | | | |
| Q | Filip Misolic | 7 | 3 | 6 | Q | Filip Misolic | 6 | 7$^8$ |
| | | | | | WC | Mili Poljičak | 3 | 6$^6$ |
| Q | Carlos Gimeno Valero | 4 | 1 | | WC | Mili Poljičak | 3 | 6$^6$ |
| WC | Mili Poljičak | 6 | 6 | | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | J Thompson | 6 | 6$^5$ | 2 | | | | | | | | | | | | | |
| Q | Y Wu | 1 | 7$^7$ | 6 | Q | Y Wu | 6 | 7 | | | | | | | | | |
| Q | F Marozsán | 7 | 1 | 0$^r$ | Alt | R Bonadio | 3 | 5 | | | | | | | | | |
| Alt | R Bonadio | 5 | 6 | 3 | | | | | Q | Y Wu | 6$^8$ | 2 | | | | | |
| | M Marterer | 6 | 3 | 1 | | | | | 6 | J Kubler | 7$^{10}$ | 6 | | | | | |
| | N Kicker | 4 | 6 | 6 | | N Kicker | 2 | 2 | | | | | | | | | |
| | F Meligeni Alves | 1 | 2 | | 6 | J Kubler | 6 | 6 | | | | | | | | | |
| 6 | J Kubler | 6 | 6 | | | | | | | | | | 6 | J Kubler | 5 | 6 | 3 |
| LL | J Shang | 7$^7$ | 3 | 7 | | | | | | | | | Q | F Misolic | 7 | 3 | 6 |
| | F Horanský | 6$^5$ | 6 | 5 | LL | J Shang | 2 | 0 | | | | | | | | | |
| | L Lacko | 4 | 1 | | Q | F Misolic | 6 | 6 | | | | | | | | | |
| Q | F Misolic | 6 | 6 | | | | | | Q | F Misolic | 7 | 6 | | | | | |
| Alt | D Ajduković | 6 | 6 | | | | | | Alt | D Ajduković | 5 | 2 | | | | | |
| LL | T Lamasine | 4 | 3 | | Alt | D Ajduković | 7$^7$ | 6 | | | | | | | | | |
| | A Müller | 4 | 6 | 6 | | A Müller | 6$^5$ | 3 | | | | | | | | | |
| 7 | JP Ficovich | 6 | 3 | 2 | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 5 | V Kopřiva | 6 | 1 | 6 | | | | | | | | | | | | |
| | D Kuzmanov | 4 | 6 | 3 | 5 | V Kopřiva | 3 | 4 | | | | | | | | |
| | N Serdarušić | 6 | 6 | | | N Serdarušić | 6 | 6 | | | | | | | | |
| WC | D Prižmić | 4 | 2 | | | | | | | N Serdarušić | 0 | 4 | | | | |
| | D Masur | 6 | 2 | 1 | | | | | Q | C Gimeno Valero | 6 | 6 | | | | |
| Q | N Fatić | 3 | 6 | 6 | Q | N Fatić | 3 | 1 | | | | | | | | |
| Q | C Gimeno Valero | 1 | 6 | 6 | Q | C Gimeno Valero | 6 | 6 | | | | | | | | |
| 3 | C O'Connell | 6 | 4 | 3 | | | | | | | | | Q | C Gimeno Valero | 4 | 1 |
| 8 | F Gaio | 7$^7$ | 6$^3$ | 6 | | | | | | | | | WC | M Poljičak | 6 | 6 |
| Q | M Neuchrist | 6$^2$ | 7$^7$ | 4 | 8 | F Gaio | 3 | 5 | | | | | | | | |
| WC | M Poljičak | 7 | 7$^8$ | | WC | M Poljičak | 6 | 7 | | | | | | | | |
| LL | Zh Zhang | 5 | 6$^6$ | | | | | | WC | M Poljičak | 6 | 6 | | | | |
| | M Bašić | 6 | 6 | | | | | | | M Bašić | 4 | 1 | | | | |
| WC | K Ivanovski | 1 | 1 | | | M Bašić | 6 | 7$^7$ | | | | | | | | |
| | A Kuznetsov | 6 | 6 | | | A Kuznetsov | 4 | 6$^5$ | | | | | | | | |
| 2 | A Vukic | 1 | 1 | | | | | | | | | | | | | |