# 2022 Open Sopra Steria de Lyon – Singles

Pablo Cuevas was the defending champion but chose not to defend his title.
Corentin Moutet won the title after defeating Pedro Cachin 6–4, 6–4 in the final.

## Seeds

* Federico Coria (quarterfinals)
* Richard Gasquet (semifinals)
* Hugo Dellien (first round)
* Pablo Andújar (first round)
* Nuno Borges (second round)
* Tomás Barrios Vera (withdrew)
* Corentin Moutet (champion)
* Manuel Guinard (semifinals)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| 8 | Manuel Guinard | 3 | 2 | | | | |
| 7 | Corentin Moutet | 6 | 6 | | | | |
| 7 | Corentin Moutet | 6 | 6 | 7 | Corentin Moutet | 6 | 6 |
| | | | | | Pedro Cachin | 4 | 4 |
| | Pedro Cachin | 6 | 7 | | Pedro Cachin | 4 | 4 |
| 2 | Richard Gasquet | 1 | 5 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | F Coria | 6 | 6 | | | | | | | | | | | | | | |
| Q | K Coppejans | 3 | 3 | | 1 | F Coria | 7$^8$ | 7$^8$ | | | | | | | | | |
| Q | A Fils | 7$^7$ | 4 | 6 | Q | A Fils | 6$^6$ | 6$^6$ | | | | | | | | | |
| | C Ugo Carabelli | 6$^5$ | 6 | 4 | | | | | 1 | F Coria | 4 | 2 | | | | | |
| | A Pellegrino | 6 | 6 | | | | | | 8 | M Guinard | 6 | 6 | | | | | |
| | GA Olivieri | 4 | 4 | | | A Pellegrino | 4 | 5 | | | | | | | | | |
| WC | U Blanchet | 5 | 3 | | 8 | M Guinard | 6 | 7 | | | | | | | | | |
| 8 | M Guinard | 7 | 6 | | | | | | | | | | | 8 | M Guinard | 3 | 2 |
| 3 | H Dellien | 3 | 1 | | | | | | | | | | | 7 | C Moutet | 6 | 6 |
| | H Grenier | 6 | 6 | | | H Grenier | 6 | 6 | | | | | | | | | |
| Q | I Gakhov | 6 | 6 | | Q | I Gakhov | 2 | 1 | | | | | | | | | |
| WC | L Van Assche | 2 | 4 | | | | | | | H Grenier | 3 | 6 | 6$^3$ | | | | |
| | E Furness | 6 | 6 | | | | | | 7 | C Moutet | 6 | 4 | 7$^7$ | | | | |
| Q | J Shang | 2 | 3 | | | E Furness | 4 | 4 | | | | | | | | | |
| | A Ritschard | 2 | 6$^3$ | | 7 | C Moutet | 6 | 6 | | | | | | | | | |
| 7 | C Moutet | 6 | 7$^7$ | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 5 | N Borges | 6 | 6 | | | | | | | | | | | | | | | |
| | G Lama | 4 | 4 | | 5 | N Borges | 4 | 2 | | | | | | | | | | |
| | F Díaz Acosta | 6$^5$ | 3 | | | A Müller | 6 | 6 | | | | | | | | | | |
| | A Müller | 7$^7$ | 6 | | | | | | | | A Müller | 6$^4$ | 6$^5$ | | | | | |
| | P Cachin | 7$^7$ | 6 | | | | | | | | P Cachin | 7$^7$ | 7$^7$ | | | | | |
| WC | K Jacquet | 6$^5$ | 4 | | | P Cachin | 4 | 6 | 7$^7$ | | | | | | | | | |
| LL | JB Torres | 6 | 6 | | LL | JB Torres | 6 | 2 | 6$^1$ | | | | | | | | | |
| 4 | P Andújar | 3 | 3 | | | | | | | | | | | | | P Cachin | 6 | 7 |
| Q | G Décamps | 6 | 6 | | | | | | | | | | | | 2 | R Gasquet | 1 | 5 |
| | T Seyboth Wild | 2 | 3 | | Q | G Décamps | 5 | 1 | | | | | | | | | | |
| Q | A Vatutin | 6 | 6 | | Q | A Vatutin | 7 | 6 | | | | | | | | | | |
| LL | M Janvier | 4 | 2 | | | | | | | Q | A Vatutin | 1 | 6 | 1 | | | | |
| | A Collarini | 6 | 6 | | | | | | | 2 | R Gasquet | 6 | 3 | 6 | | | | |
| | J Sels | 4 | 4 | | | A Collarini | 7$^7$ | 4 | 2 | | | | | | | | | |
| | G Barrère | 4 | 6 | 1 | 2 | R Gasquet | 6$^2$ | 6 | 6 | | | | | | | | | |
| 2 | R Gasquet | 6 | 4 | 6 | | | | | | | | | | | | | | |