# 2022 Zagreb Ladies Open – Singles

Anhelina Kalinina was the defending champion but chose not to participate.
Jule Niemeier won the title, defeating Réka Luca Jani in the final, 6–2, 6–2.

## Seeds

* Donna Vekić (first round)
* Jule Niemeier (champion)
* Réka Luca Jani (final)
* Paula Ormaechea (second round)
* Polona Hercog (first round)
* Despina Papamichail (second round)
* Anna-Lena Friedsam (first round, retired)
* Linda Nosková (second round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| | Dea Herdželaš | 0 | 0$^r$ | | | | |
| 3 | Réka Luca Jani | 6 | 3 | | | | |
| 3 | Réka Luca Jani | 6 | 3 | 3 | Réka Luca Jani | 2 | 2 |
| | | | | 2 | Jule Niemeier | 6 | 6 |
| WC | Petra Marčinko | 6$^4$ | 1 | 2 | Jule Niemeier | 6 | 6 |
| 2 | Jule Niemeier | 7$^7$ | 6 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1/WC | D Vekić | 4 | 4 | | | | | | | | | | | | | | | |
| | J Fourlis | 6 | 6 | | | J Fourlis | 3 | 3 | | | | | | | | | | |
| | D Herdželaš | 5 | 6 | 6 | | D Herdželaš | 6 | 6 | | | | | | | | | | |
| WC | L Ćirić Bagarić | 7 | 3 | 1 | | | | | | | D Herdželaš | 1 | 7 | 6 | | | | |
| | K von Deichmann | 6 | 2 | 6 | | | | | | Q | T Lukas | 6 | 5 | 4 | | | | |
| | V Kužmová | 3 | 6 | 2 | | K von Deichmann | 3 | 6 | 3 | | | | | | | | | |
| Q | T Lukas | 6 | 4 | | Q | T Lukas | 6 | 3 | 6 | | | | | | | | | |
| 7 | A-L Friedsam | 0 | 1$^r$ | | | | | | | | | | | | | D Herdželaš | 0 | 0$^r$ |
| 3 | RL Jani | 6 | 6 | | | | | | | | | | | | 3 | RL Jani | 6 | 3 |
| | J Grabher | 3 | 2 | | 3 | RL Jani | 7$^8$ | 6 | | | | | | | | | | |
| Q | N Potočnik | 6 | 7 | | Q | N Potočnik | 6$^6$ | 4 | | | | | | | | | | |
| | H Chang | 2 | 5 | | | | | | | 3 | RL Jani | 6 | 6 | | | | | |
| | B Haas | 4 | 6 | 2 | | | | | | Q | A Ružić | 4 | 1 | | | | | |
| Q | T Würth | 6 | 2 | 6 | Q | T Würth | 4 | 1 | | | | | | | | | | |
| Q | A Ružić | 7 | 6 | | Q | A Ružić | 6 | 6 | | | | | | | | | | |
| 5 | P Hercog | 5 | 3 | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 6 | D Papamichail | 3 | 3 | | | | | | | | | | | | | | |
| | J Fett | 6 | 1$^r$ | | 6 | D Papamichail | 1 | 3 | | | | | | | | | |
| | C Ferrando | 6 | 4 | 5 | WC | P Marčinko | 6 | 6 | | | | | | | | | |
| WC | P Marčinko | 4 | 6 | 7 | | | | | | WC | P Marčinko | 6 | 6 | | | | |
| | A Kulikova | 4 | 7 | 4 | | | | | | | K Zavatska | 3 | 1 | | | | |
| | K Zavatska | 6 | 5 | 6 | | K Zavatska | 6 | 6 | | | | | | | | | |
| WC | L Radivojević | 2 | 3 | | 4 | P Ormaechea | 1 | 0 | | | | | | | | | |
| 4 | P Ormaechea | 6 | 6 | | | | | | | | | | | WC | P Marčinko | 6$^4$ | 1 |
| 8 | L Nosková | 7 | 7 | | | | | | | | | | | 2 | J Niemeier | 7$^7$ | 6 |
| Q | L Bošković | 5 | 5 | | 8 | L Nosková | 3 | 7 | 0 | | | | | | | | |
| Q | E Makarova | 6 | 4 | 2 | | I Shymanovich | 6 | 5 | 6 | | | | | | | | |
| | I Shymanovich | 4 | 6 | 6 | | | | | | | I Shymanovich | 4 | 6$^1$ | | | | |
| Q | E Lys | 6 | 4 | | | | | | | 2 | J Niemeier | 6 | 7$^7$ | | | | |
| | N Vikhlyantseva | 4 | 1$^r$ | | Q | E Lys | 0$^r$ | | | | | | | | | | |
| Q | Ž Falkner | 2 | 4 | | 2 | J Niemeier | 3 | | | | | | | | | | |
| 2 | J Niemeier | 6 | 6 | | | | | | | | | | | | | | |