# 2022 Cleveland Open – Singles

Bjorn Fratangelo was the defending champion but lost in the first round to Nicola Kuhn.
Dominic Stricker won the title after defeating Yoshihito Nishioka 7–5, 6–1 in the final.

## Seeds

* Tennys Sandgren (second round)
* Andreas Seppi (first round)
* Yoshihito Nishioka (final)
* Liam Broady (second round)
* Jurij Rodionov (second round)
* Ernesto Escobedo (quarterfinals)
* Emilio Gómez (second round, retired)
* Jack Sock (second round, retired)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| | Thomas Fabbiano | 6$^6$ | 3 | | | | | |
| 3 | Yoshihito Nishioka | 7$^8$ | 6 | | | | | |
| 3 | Yoshihito Nishioka | 7$^8$ | 6 | | 3 | Yoshihito Nishioka | 5 | 1 |
| | | | | | | Dominic Stricker | 7 | 6 |
| | Michael Mmoh | 6 | 3 | 6$^2$ | | Dominic Stricker | 7 | 6 |
| | Dominic Stricker | 3 | 6 | 7$^7$ | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | T Sandgren | 7$^7$ | 3 | 7$^7$ | | | | | | | | | | | | | | |
| | C Harrison | 6$^5$ | 6 | 6$^3$ | 1 | T Sandgren | 6 | 4 | 1 | | | | | | | | | |
| | T Fabbiano | 7 | 6 | | | T Fabbiano | 3 | 6 | 6 | | | | | | | | | |
| | M Krueger | 5 | 3 | | | | | | | | T Fabbiano | 6 | 6 | | | | | |
| | C-M Stebe | 4 | 6 | 6 | | | | | | | C-M Stebe | 1 | 3 | | | | | |
| | M Torpegaard | 6 | 4 | 2 | | C-M Stebe | 7 | 3 | 6 | | | | | | | | | |
| Q | R Hijikata | 6$^4$ | 3 | | 5 | J Rodionov | 5 | 6 | 1 | | | | | | | | | |
| 5 | J Rodionov | 7$^7$ | 6 | | | | | | | | | | | | | T Fabbiano | 6$^6$ | 3 |
| 3 | Y Nishioka | 6 | 6 | | | | | | | | | | | | 3 | Y Nishioka | 7$^8$ | 6 |
| | D Istomin | 1 | 1 | | 3 | Y Nishioka | 6 | 1 | 6 | | | | | | | | | |
| | Y Uchiyama | 6 | 6 | | | Y Uchiyama | 4 | 6 | 4 | | | | | | | | | |
| Q | S Fanselow | 4 | 3 | | | | | | | 3 | Y Nishioka | 3 | 6 | 6 | | | | |
| Q | R Quiroz | 4 | 7$^9$ | 4 | | | | | | WC | W Blumberg | 6 | 4 | 2 | | | | |
| WC | W Blumberg | 6 | 6$^7$ | 6 | WC | W Blumberg | 6 | 3 | | | | | | | | | | |
| | J Jung | 3 | 4 | | 7 | E Gómez | 1 | 1$^r$ | | | | | | | | | | |
| 7 | E Gómez | 6 | 6 | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 8 | J Sock | 2 | 6 | 6 | | | | | | | | | | | | | | |
| | B Schnur | 6 | 4 | 3 | 8 | J Sock | 1 | 1$^r$ | | | | | | | | | | |
| | M Mmoh | 6 | 6 | | | M Mmoh | 6 | 2 | | | | | | | | | | |
| WC | A Kovacevic | 4 | 2 | | | | | | | | M Mmoh | 6$^3$ | 6 | 6 | | | | |
| Q | A Galarneau | 7$^7$ | 7$^7$ | | | | | | | Q | A Galarneau | 7$^7$ | 3 | 0 | | | | |
| Q | U Blanch | 6$^5$ | 6$^3$ | | Q | A Galarneau | 6 | 7 | | | | | | | | | | |
| | J. J. Wolf | 4 | 1 | | 4 | L Broady | 1 | 5 | | | | | | | | | | |
| 4 | L Broady | 6 | 6 | | | | | | | | | | | | M Mmoh | 6 | 3 | 6$^2$ |
| 6 | E Escobedo | 7$^7$ | 6 | | | | | | | | | | | | D Stricker | 3 | 6 | 7$^7$ |
| WC | K Smith | 6$^3$ | 4 | | 6 | E Escobedo | 6$^6$ | 7 | 4 | | | | | | | | | |
| | N Kuhn | 7$^{10}$ | 6 | | | N Kuhn | 7$^8$ | 5 | 0$^r$ | | | | | | | | | |
| | B Fratangelo | 6$^8$ | 4 | | | | | | | 6 | E Escobedo | 3 | 6$^4$ | | | | | |
| | G Blancaneaux | 4 | 7$^7$ | 6$^5$ | | | | | | | D Stricker | 6 | 7$^7$ | | | | | |
| Q | Em Nava | 6 | 6$^5$ | 7$^7$ | Q | Em Nava | 6 | 3 | 4 | | | | | | | | | |
| | D Stricker | 6 | 6 | | | D Stricker | 3 | 6 | 6 | | | | | | | | | |
| 2 | A Seppi | 4 | 4 | | | | | | | | | | | | | | | |