# John Holloway (geneticist)

John William Holloway is a geneticist based at the University of Southampton, where he is professor of allergy and respiratory genetics, and was appointed associate vice-president interdisciplinary research in 2021. He leads a research team based within the human genetics and medical genomics theme of the School of Human Development & Health, Faculty of Medicine. Holloway is a Fellow of the Higher Education Academy.

## Education

Holloway obtained a BSc degree in biochemistry from the University of Otago in New Zealand in 1992. He then went on to carry out research with the University of Southampton and the Malaghan Institute, which resulted in his gaining a PhD from the University of Otago in 1997. His thesis focussed on the genetic basis of atopic asthma.

## Career

Holloway returned to the University of Southampton in 1997 and worked with Stephen Holgate. The main focus of his research was the genetics behind asthma and allergies. He currently leads the Respiratory Genetics Group in the University of Southampton's Faculty of Medicine. He was appointed to a chair of the Faculty of Medicine in 2011.
Holloway was previously on the Scientific Advisary boards for Asthma UK, and was a member of the Council for the British Society of Allergy and Clinial Immunology from 2009 to 2012. He is currently associate vice-president interdisciplinary research and sat on the council of the University of Southampton (2018-24). He was also previously Associate Dean (Enterprise and International) and Associate Dean (Research) for the Faculty of Medicine, University of Southampton.

### Selected publications

* Holgate ST, Davies DE, Rorke S, Cakebread J, Murphy G, Powell RM, Holloway JW. ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma. Clin Rev Allergy Immunol. 2004 Aug;27(1):23-34. doi: 10.1385/CRIAI:27:1:023. PMID 15347848.
* Erb KJ, Holloway JW, Sobeck A, Moll H, Le Gros G. Infection of mice with Mycobacterium bovis-Bacillus Calmette-Guérin (BCG) suppresses allergen-induced airway eosinophilia. J Exp Med. 1998 Feb 16;187(4):561-9. doi: 10.1084/jem.187.4.561. PMID 9463406; PMCID: PMC2212158.
* Holloway JW, Yang IA, Holgate ST. Genetics of allergic disease. J Allergy Clin Immunol. 2010 Feb;125(2 Suppl 2):S81-94. doi: 10.1016/j.jaci.2009.10.071. PMID 20176270.
* Granell R, Curtin JA, Haider S, Kitaba NT, Mathie SA, Gregory LG, Yates LL, Tutino M, Hankinson J, Perretti M, Vonk JM, Arshad HS, Cullinan P, Fontanella S, Roberts GC, Koppelman GH, Simpson A, Turner SW, Murray CS, Lloyd CM, Holloway JW, Custovic A; UNICORN and Breathing Together investigators. A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing. Elife. 2023 May 25;12:e84315. doi: 10.7554/eLife.84315. PMID 37227431; PMCID: PMC10292845.
* Kitaba NT, Knudsen GTM, Johannessen A, Rezwan FI, Malinovschi A, Oudin A, Benediktsdottir B, Martino D, González FJC, Gómez LP, Holm M, Jõgi NO, Dharmage SC, Skulstad SM, Watkins SH, Suderman M, Gómez-Real F, Schlünssen V, Svanes C, Holloway JW. Fathers' preconception smoking and offspring DNA methylation. Clin Epigenetics. 2023 Aug 31;15(1):131. doi: 10.1186/s13148-023-01540-7. PMID 37649101; PMCID: PMC10469907.

## Personal life

Holloway is the son of Scottish anatomical pathologist Linda Holloway and forester John Stevenson Holloway, and the grandson of alpine explorer and forest ecologist John Thorpe Holloway. He is married to Judith Holloway, also a professor at Southampton, with whom he has two children.