# Capsugel

Capsugel is a company that manufactures and sells two-piece hard gelatin drug capsules.$^{:703}$ Capsugel also sells equipment for filling empty and liquid capsules, as well as equipment for sealing liquid capsules.

## History

Capsugel was founded in the 1960s as a division of Parke-Davis. In 1970, Parke-Davis, including Capsugel, was acquired by Warner Lambert, which was acquired by Pfizer in 2000. On 1 August 2011, Pfizer sold Capsugel to global investment firm Kohlberg Kravis Roberts for $2.38 billion. In July 2017, the Lonza Group completed the acquisition of Capsugel for $5.5 billion from Kohlberg Kravis Roberts. In 1987, while a subsidiary of Warner Lambert, the firm was one of only five pharmaceutical joint ventures in China, the joint venture firm being Suzhou Capsugel Ltd.
According to one source, Capsugel originated technology for the production of hard shell capsules from starch.

### Executive history

Charles Hoover was promoted to President of the company in 1989; he had previously served as the general manager of the company's largest manufacturing facility and had introduced quality improvement to the company starting in 1982.$^{:706–707}$ During his tenure as President, he introduced a company-wide focus on statistical process control.$^{:707}$ By 2016, the company's President and chief executive officer (CEO) was Guido Driesen.

## Products
### Coni-Snap

Coni-Snap capsules are a standard two-part hard gelatin capsule that are usually filled with either powder or granules (though they can also be filled with pellets, tablets, pastes, or liquids). Coni-Snap capsules are distributed in multiple sizes and colors.
The body section of the Coni-Snap design has a tapered rim to facilitate encapsulation on high-speed capsule-filling machines. It has a dual snap-ring locking system that provides an initial attachment prior to capsule filling and a final closure of the filled capsule. The Coni-Snap design also includes air vents to avoid unwanted air compression within the capsule during high speed filling.

### DBcaps

DBcaps capsules are a line of capsules designed specifically for use in double-blind studies. These opaque capsules are large enough to encapsulate a range of tablet sizes, so splitting or grinding is not required, reducing variability in the study. The DBcap capsule design also incorporates a locking design to prevent the participants from opening the capsules and breaking the blind.

### Vcaps

Vcaps capsules are a two-piece capsule made of hydroxypropyl methylcellulose, a cellulose-based raw material. They were designed to meet restrictive dietary needs, and are thus gluten-free, vegan, kosher, and halaal.

### Licaps

Licaps capsules are two-piece gelatin or hydroxypropyl methylcellulose capsules designed specifically for containing liquids or semi-solids. Licaps can be used when drugs' ingredients are more stable as a liquid, such as in dietary supplements.

## Facilities

As of 1991, the company's four largest manufacturing plants were located in the United States (Greenwood, South Carolina),$^{:709}$ Belgium, France and Japan; smaller manufacturing units were located in Britain, Mexico, Italy, Thailand, Brazil and China.$^{:704}$

## Intellectual property

European patent EP2844297 "Aqueous Dispersions of Controlled Release Polymers and Shells and Capsules Thereof", filed in 2013, was granted to the Belgium unit of Capsugel in 2018 with an anticipated expiry in 2033.
European patent EP2844296 "Aqueous Dispersions of Hydroxypropyl Methylcellulose Acetate Succinate (HPMCAS)", filed in 2013, was granted to the Belgium unit of Capsugel in 2019 with an anticipated expiry in 2033.