OpenLLM-France/wikimedia huggingface dataset:
# Neuropilin 1

Neuropilin-1 is a protein that in humans is encoded by the NRP1 gene. In humans, the neuropilin 1 gene is located at 10p11.22. This is one of two human neuropilins.

## Function

NRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (for example, VEGFA) and semaphorin (for example, SEMA3A) family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.[supplied by OMIM]

## Interactions

Neuropilin 1 has been shown to interact with Vascular endothelial growth factor A.

## Role in COVID-19

Research has shown that neuropilin 1 facilitates entry of SARS-CoV-2 into cells, making it a possible target for future antiviral drugs.

## Implication in cancer

Neuropilin 1 has been implicated in the vascularization and progression of cancers. NRP1 expression has been shown to be elevated in a number of human patient tumor samples, including brain, prostate, breast, colon, and lung cancers and NRP1 levels are positively correlated with metastasis.
In prostate cancer NRP1 has been demonstrated to be an androgen-suppressed gene, upregulated during the adaptive response of prostate tumors to androgen-targeted therapies and a prognostic biomarker of clinical metastasis and lethal PCa. In vitro and in vivo mouse studies have shown membrane bound NRP1 to be proangiogenic and that NRP1 promotes the vascularization of prostate tumors.
Elevated NRP1 expression is also correlated with the invasiveness of non-small cell lung cancer both in vitro and in vivo.

### Target for cancer therapies

As a co-receptor for VEGF, NRP1 is a potential target for cancer therapies. A synthetic peptide, EG3287, was generated in 2005 and has been shown to block NRP1 activity. EG3287 has been shown to induce apoptosis in tumor cells with elevated NRP1 expression. A patent for EG3287 was filed in 2002 and approved in 2003. As of 2015 there were no clinical trials ongoing or completed for EG3287 as a human cancer therapy.
Soluble NRP1 has the opposite effect of membrane bound NRP1 and has anti-VEGF activity. In vivo mouse studies have shown that injections of sNRP-1 inhibits progression of acute myeloid leukemia in mice.
# Hasan Rizvi (artist)

Hasan Rizvi (born 1984) is a Pakistani artist, host, and choreographer.

## Early life and education

Hasan Rizvi was born in 1984. He holds a bachelor's degree with a major in economics. He is a brother of Komal Rizvi.

## Career

In 2010, the US Department of State designated Rizvi as the "Hip Hop Ambassador" from Pakistan.
In 2012, Rizvi was recognized for introducing "Cinema Live," a fusion of Hip-Hop, Bhangra, and Bollywood dance tableaus in Pakistan.
In 2016, Hasan Rizvi and his team launched a concert series and released six music videos through Cornetto Pop Rock. In the same year, Rizvi organized the Bridal Couture Week.
Over the years, Rizvi has worked as choreographer for films such as Main Hoon Shahid Afridi, Hijrat, and Lahore Se Aagay. He has also directed commercials for brands including Blue Band, Lipton, Nestle, Samsung, Tang, and Tapal Tea. He is also credited for his work on a musical project called Pepsi Unplugged. He has also hosted multiple events such as Oh! My Gosh, Oh! Behave, and Oh! So Pop, as part of the Oh! series.
Rizvi is also the founder of BodyBeat Group, which includes a health and fitness studio called BBRC and a dance studio called BodyBeat Productions.

## Choreography

* Naach
* Main Hoon Shahid Afridi
* Hijrat
* Lahore Se Aagay
* Bridal Couture Week
# Redback Aviation

Redback Aviation is an Australian aircraft manufacturer based in Hoppers Crossing, Victoria. The company is engaged in the development of kit and plans-built helicopter designs for amateur construction.

## History

The company was formed to design plans and supply kits for home-built helicopters, initially proposing two designs, which were to be developed concurrently. The Buzzard is a minimalist, open frame, single seat helicopter of limited performance, powered by a Suzuki four stroke automotive engine of 56 kW (75 hp). Only one prototype was completed and this was later sold. The company then turned its attention to designing a more capable helicopter, to be designated the Redback Aviation Spider. By 2014 design work on the Spider was proceeding slowly as outside investment was not sought and resources were limited.
Redback's focus is on traditional methods and where possible, commercial off-the-shelf components, to save money and decrease development time, as well as builder construction time. The company states its design aims as "low maintenance (by comparison to the traditional Rotorway Exec and Scorpion designs), improved safety, and high performance".
The company is named after the venomous Redback spider, which is indigenous to Australia.
# Bob Richards (meteorologist)

Robert "Bob" Richards (January 10, 1956 – March 23, 1994), born Robert L. Schwartz, was an American local television personality on KSDK in St. Louis, Missouri, where he worked as chief meteorologist in the 1980s and early 1990s. He began his career as a meteorologist at WOLO-TV in Columbia, South Carolina; WATE-TV in Knoxville, Tennessee; and WSB-TV in Atlanta before leaving to join The Weather Channel. While at WATE, he earned the Seal of Approval from the American Meteorological Society. Because of The Weather Channel's connection to its founder John Coleman, former weather forecaster for ABC's Good Morning America, Richards occasionally filled in on that show's morning broadcasts. Later he moved on to the short-lived Satellite News Channel before joining KSDK in 1983.
Richards' death resulted from a plane crash, which is thought to have been suicide due to his anxiety over an alleged extra-marital affair that was increasingly becoming public knowledge. After a radio interview in which his former girlfriend provided messages he had left on her phone answering machine, Richards became despondent. After delivering the 10pm weather report on the night of March 23, 1994, Richards took off from Spirit of St. Louis Airport in Chesterfield, Missouri, and flew his plane, a Piper Cherokee, into the ground.
# Bernhard Heinrich Irrgang

Bernhard Heinrich Irrgang (23 July 1869 – 8 April 1916) was a German organist, composer and docent for organ practice.

## Life

Irrgang was born in Zduny, former Province of Posen. His father was a Protestant cantor and teacher in Zduny. Bernhard was educated at the Royal Music Institute of Berlin from 1890 to 1896 and in the academic master class in composition. Active as an organist in various parishes from the beginning of his studies, Irrgang was a member of the Berlin Philharmonic from 1897.Memorial Bernhard Irrgang. Archived 2015-06-10 at the Wayback Machine In Berlin.Friedparks.de. The pupil Otto Dienel [de] worked from 1894 to 1905 as organist at the newly built Heilig-Kreuz-Kirche [de; fr; nl] in Kreuzberg, then until 1910 as music director at the St. Mary's Church, Berlin. From 1910, he was organist at the Berlin Cathedral.
The organ virtuoso was known in Berlin for his "groundbreaking" concerts. Among his performances were over 550 free weekly concerts, at which he performed, among others, compositions by Josef Rheinberger's In 1909 Irrgang made a concert tour to Sweden.
From 1905, he taught organ playing at the Stern conservatory and from 1912 at the Royal Music Institute of Berlin. Among his pupils was John J. McClellan. Irrgang composed organ sonatas and sacred songs, motets and aria in his sonatas following the tradition of Felix Mendelssohn Bartholdy and Josef Rheinberger. For Irrgang's appreciation of Rheinberger, see his letter dated 5 October 1901: Bernhard Irrgang introduces himself to Rheinberger by letter as an admirer and thanks him for Sonata No. 20. In J. G. Rheinberger-Archiv, Vaduz.
Robert Breuer [de] counted Irrgang's organ playing "among the most manly memories of our youth." For Richard Gölz [de; la], who met him in 1914, he was one of the "great organ masters" of the time.
Irrgang died in Berlin at the age of 46. The gravesite is located at the Liesenstraße [de; pt]. The State Institute for Music Research Berlin has a Bernhard Irrgang Collection which contains organ appraisals, concert reviews and programmes, and sheet music; the Staatsbibliothek zu Berlin keeps 87 of Irrgang's autographs in its music department, mainly letters.

## Work

* Choralbuch zu dem Deutsches Evangelisches Gesangbuch [de]. Im Auftrag des Deutschen Evangelischen Kirchenausschusses. Mittler, Berlin 1916.
# Depressaria radiosquamella

Depressaria radiosquamella is a moth of the family Depressariidae. It is found on Corsica.
The wingspan is 20–24 mm. The forewings are pale cinereous (ash-grey) with a rosy tinge and smeared with fuscous, especially towards the base of the fold and dorsum. The hindwings are shining pale bone colour.
# Oxalis enneaphylla

Oxalis enneaphylla, or scurvy grass, is a late spring- and summer-flowering, rhizomatous, alpine perennial herbaceous plant native to the grasslands of Patagonia and the Falkland Islands. It is a small plant that grows to 7 cm (2.8 in) high and 10 cm (3.9 in) across, with slightly fleshy, hairy, blue-grey leaves, which are edible but have a sharp taste due to their high oxalic acid content. The name enneaphylla comes from the Greek εννεα (ennea), "nine" and φυλλον (phyllon), "leaf".
The almond-scented, five-petalled flowers are pink shading to white. They are hermaphrodite and pollinated by Lepidoptera (moths and butterflies).
The plant gets its common name "scurvy grass" from the fact that its leaves are rich in vitamin C. It is not closely related to the other plant known as scurvy-grass (Cochlearia), nor is either plant a grass (Poaceae).
Sailors travelling around Cape Horn would consume the leaves to avoid scurvy. This is illustrated by this extract from the Journal of Syms Covington, who sailed aboard HMS Beagle with Charles Darwin. Here he describes the Falkland Islands, and refers to Oxalis enneaphylla as "wild thyme":
   While laying here we found it very squally, and at times very cold. The island is in general mountainous. Not a single tree to be seen but there are low brushes with red berries which are very good eating. Here are bullocks horses and pigs that run wild, rabbits, wild geese and ducks and most excellent snipe shooting on the marshy ground and long grass, of which the island in general has very little else. Likewise there is the tea plant, which bears very sweet berry, and wild thyme which we used as tea, and is very good and much more plentiful than the former.
This plant is cultivated in temperate regions, and is suitable for rockeries or alpine gardens. The species and the hybrid cultivar 'Ione Hecker' have gained the Royal Horticultural Society's Award of Garden Merit.
# Certified information technology professional

Certified Information Technology Professional (CITP) is a professional certification for professionals in the field of information technology (IT). The credential is given to Certified Practising Accountants (CPAs) only; however, professionals of varied qualifications may apply depending on the organization offering the certification.
Most firms that offer this certification require an unrevoked and valid CPA license. It is administered by the AICPA through the National Accreditation Commission via a volunteer committee and staff. The committee was formed in 2003 and initially chaired, through 2005, by Michael Dickson.

## Qualifications

In some firms, CITP is offered only to those who have completed a formal exam, which includes the five CITP Body of Knowledge areas:
* Risk Assessment
* Fraud Considerations
* Internal Controls & Information Technology General Controls
* Evaluate, Test and Report
* Information Management and Business Intelligence
In addition, certain certifications and advanced degrees also apply.

### CITP Multiple Entry Point System (MEP)

To be awarded the CITP Credential, a CPA must accumulate 100 total points. On the CITP Credential Application, one will be asked to sign a Declaration and Intent to comply with all the requirements for CITP recertification. A percentage of CITP applications will be randomly selected for further review each year, and if selected, the applicant agrees to provide detailed documentation to support the assertions of the application. Total points will be earned based on business experience, lifelong learning, and, if required, the results of an examination. The business experience requirements are:
* The candidate must earn a minimum of 25 points within the five-year period preceding the date of application.
* 40 hours of IT-related business experience equals approximately 1 point.
* You must earn a minimum of 25 points in lifelong learning within the five-year period preceding the date of application.
The maximum number of business experience points that can be earned over the preceding five-year period is 60.
# Ian Corbett

Ian Deighton Corbett was Dean of Tuam from 1997 to 1999.
Corbett was born in 1942, educated at St Catharine's College, Cambridge and Westcott House Cambridge and ordained in 1969.
After a curacy in Bury he was Chaplain at Bolton Polytechnic. He was the Diocese of Manchester's further education officer from 1974 to 1983 and rector of St John Chrysostom, Victoria Park, from 1975 to 1980. He was the chaplain of Salford Polytechnic from 1980 to 1983; and rector of Sacred Trinity, Salford from 1983 to 1987. He was warden of Lelapa la Jesu Sem Lesotho from 1988 to 1991; a missionary in Zimbabwe then Botswana from 1991 until 1995 and rector of St Mary, Kuruman, from 1995 to 1997. After his time as dean, he was rector of White Sands, Alberta from 1999 until 2001, when he moved to work in Utah. He retired in 2008. He is now an honorary curate in Clevedon.
# Neuropilin

Neuropilin is a protein receptor active in neurons.
There are two forms of Neuropilins, NRP-1 and NRP-2. Neuropilins are transmembrane glycoproteins, first documented to regulate neurogenesis and angiogenesis by complexing with Plexin receptors/class-3 semaphorin ligands and Vascular Endothelial Growth Factor (VEGF) receptors/VEGF ligands, respectively. Neuropilins predominantly act as co-receptors as they have a very small cytoplasmic domain and thus rely upon other cell surface receptors to transduce their signals across a cell membrane. Recent studies have shown that Neuropilins are multifunctional and can partner with a wide variety of transmembrane receptors. Neuropilins are therefore associated with numerous signalling pathways including those activated by Epidermal Growth Factor (EGF), Fibroblast Growth Factor (FGF), Hepatocyte Growth Factor (HGF), Insulin-like Growth Factor (IGF), Platelet Derived Growth Factor (PDGF) and Transforming Growth Factor beta (TGFβ). Although Neuropilins are commonly found at the cell surface, they have also been reported within the mitochondria and nucleus. Both Neuropilin family members can also be found in soluble forms created by alternative splicing or by ectodomain shedding from the cell surface.
The pleiotropic nature of the NRP receptors results in their involvement in cellular processes, such as axon guidance and angiogenesis, the immune response and remyelination. Therefore, dysregulation of NRP activity has been implicated in many pathological conditions, including many types of cancer and cardiovascular disease.

## Applications

Neuropilin-1 is a therapeutic target protein in the treatment for leukemia and lymphoma, since It has been shown that there is increased expression in neuropilin-1 in leukemia and lymphoma cell lines. Also, antagonism of neuropilin-1 has been found to inhibit tumour cell migration and adhesion.

## Structure

Neuropilins contain the following four domains:
* N-terminal CUB domain (for complement C1r/C1s, Uegf, Bmp1)
* Coagulation factor 5/8 type, C-terminal (discoidin domain)
* MAM domain (for meprin, A-5 protein, and receptor protein-tyrosine phosphatase mu)
* C-terminal neuropilin
The structure of B1 domain (coagulation factor 5/8 type) of neuropilin-1 was determined through X-Ray Diffraction with a resolution of 2.90 Å. The secondary structure of this domain is 5% alpha helical and 46% beta sheet.
# Athletics at the 2004 Summer Paralympics – Men's 10000 metres T11–13

Men's 10,000m races for blind and visually impaired athletes at the 2004 Summer Paralympics were held in the Athens Olympic Stadium. Events were held in two disability classes, each class running a single race.

## T11

The T11 event was won by Henry Wanyoike, representing Kenya.

### Final Round

19 September 2004, 19:35
| Rank | Athlete | Time | Notes |
| | Henry Wanyoike (KEN) | 31:37.25 | WR |
| | Carlos Amaral Ferreira (POR) | 33:17.30 | |
| | Andrea Cionna (ITA) | 33:59.98 | |
| 4 | Yuichi Takahashi (JPN) | 34:36.69 | |
| 5 | Robert Matthews MBE (GBR) | 34:47.66 | |
| 6 | Ricardo Vale (POR) | 35:02.93 | |
| 7 | Nicolas Ledesma (MEX) | 35:42.03 | |
| 8 | Yoshihide Fukuhara (JPN) | 35:52.89 | |
| 9 | Pedro Acosta (MEX) | 36:06.13 | |
| 10 | Martin E. Mosso (COL) | 36:39.14 | |
| 11 | Clemente Esquivel (MEX) | 37:05.11 | |
| 12 | Carlo Durante (ITA) | 37:46.96 | |
| | Zhang Zhen (CHN) | DNF | |

## T13

The T13 event was won by Maher Bouallegue, representing Tunisia.

### Final Round

20 September 2004, 20:15
| Rank | Athlete | Time | Notes |
| | Maher Bouallegue (TUN) | 32:02.16 | PR |
| | Diosmani Gonzalez (CUB) | 32:04.32 | |
| | Kestutis Bartkenas (LTU) | 32:05.17 | PR |
| 4 | Noel Thatcher MBE (GBR) | 32:20.76 | |
| 5 | Said Gomez (PAN) | 32:28.96 | |
| 6 | Ildar Pomykalov (RUS) | 32:33.55 | |
| 7 | Moisés Beristáin (MEX) | 33:10.22 | |
| 8 | Daniel Ramirez (MEX) | 33:11.79 | |
| 9 | Qi Shun (CHN) | 34:10.63 | |
| 10 | Fabrizio Cocchi (ITA) | 34:16.62 | |
| 11 | Nicolai Ciumac (MDA) | 34:20.88 | |
| 12 | Vedran Lozanov (CRO) | 34:38.54 | |
| 13 | Igor Lisnic (MDA) | 34:41.58 | |
| 14 | Tomasz Chmurzynski (POL) | 34:47.63 | |
| 15 | German Nava (MEX) | 35:54.51 | |
| 16 | Zeinolla Seitov (KAZ) | 37:29.15 | |
| | Linas Balsys (LTU) | DNF | |
# Caspar (disambiguation)

Caspar is a masculine given name.
Caspar may also refer to:
* Caspar, California, a census-designated place
* Fort Caspar, Wyoming, a former US Army military post on the National Register of Historic Places
* CASPAR digital preservation project
* Azerbaijan Caspian Shipping Company, abbreviated as Caspar
# Don River (Victoria)

The Don River is a perennial river of the Port Phillip catchment, located in the Central region of the Australian state of Victoria.

## Location and features

The Don River rises below Mount Toolebewong, part of the Yarra Ranges of the Great Dividing Range, in remote country within the Yarra Ranges National Park. The river flows generally south by west before reaching its confluence with the Yarra River near Don Valley.
# Peace Island (Huajiachi)

Peace Island (Chinese: 和平岛), is an island located in Huajiachi, Hangzhou, Zhejiang Province, People's Republic of China.

## Introduction

The island is located in Hujiachi (in Huajiachi Campus, Zhejiang University), which is the second largest lake in Hangzhou, after West Lake.
The island was naturally formed, but later enlarged artificially. In the 1980s and 1990s, Chinese pavilions and other traditional structures were built on the island. Currently it boasts two pavilions, some statues and a grove of trees.
The island provides a place for relaxation and beautiful vistas of both the lake and the campus. In years past, an annual boat race was held on Hujiachi, and the spectators, cheerleaders and judges would watch from the island.
Essays by Zhejiang University alumni and other Hangzhou writers often mention this small but beautiful island.
# Jenkins Commission

Jenkins Commission may refer to:
* Jenkins Commission (UK) or Independent Commission on the Voting System, a commission formed to reform the voting system of the United Kingdom
* Jenkins Commission (EU), the European Commission that held office from 6 January 1977 to 6 January 1981; its president was Roy Jenkins
# Oxalis depressa

Oxalis depressa is an Oxalis species found in South Africa. It was first described in 1834.
# Certified broadcast radio engineer

Certified broadcast radio engineer (CBRE) is a title granted to an individual in the United States who successfully meets the experience and test requirements of the certification, regulated by the Society of Broadcast Engineers (SBE). The CBRE title is protected by copyright laws. Individuals who use this title without consent from the Society of Broadcast Engineers could face legal action.
The SBE certifications were created to recognize individuals who practice in career fields which are not regulated by state licensing or Professional Engineering programs. Broadcast Engineering is regulated at the national level and not by individual states.
# Ramshaw, Bishop Auckland

Ramshaw is a village in County Durham, in England. It is situated to the south-west of Bishop Auckland. Ramshaw was originally a mining village and is home to one restaurant, the Bridge Inn. The River Gaunless runs through Ramshaw. The name Gaunless itself is of later Norse origin, meaning useless. It is believed that this derives from the river's inability to power a mill, sustain fish or create fertile floodplains. The bridge connecting Ramshaw with neighbouring village Evenwood is between 300 and 500 years old.

## Landmarks

There is a formal garden in Ramshaw, named Ramshaw Hall Garden, which contains walls originating in the late 17th century.

## Education

There is a primary school, named Ramshaw Primary School, which educates students aged 4 to 11 years. As of 21 July 2023, it has 63 pupils.
# Elachiptera cornuta

Elachiptera cornuta is a species of fly in the family Chloropidae, the grass flies. It is found in the Palearctic . The larva feeds on Poaceae.It is a pest of maize and wheat.
# Athletics at the 2004 Summer Paralympics – Men's 1500 metres T36–37

Men's 1500m races for athletes with cerebral palsy at the 2004 Summer Paralympics were held in the Athens Olympic Stadium on 20 & 26 September. Events were held in two disability classes, each running a single race.

## T36

The T36 event consisted of a single race. It was won by Artem Arefyev, representing Russia.

### Final Round

26 September 2004, 19:30
| Rank | Athlete | Time | Notes |
| | Artem Arefyev (RUS) | 4:37.75 | WR |
| | Jose M. Pampano (ESP) | 4:39.80 | |
| | He Cheng En (CHN) | 4:40.32 | |
| 4 | Choi Yong Jin (KOR) | 4:50.98 | |
| 5 | Malcolm Bennett (AUS) | 5:04.71 | |
| 6 | Konstantinos Gasparidis (GRE) | 5:08.05 | |
| 7 | Angelo Perez Galan (ESP) | 5:19.00 | |
| 8 | Panagiotis Karaseridis (GRE) | 5:19.69 | |

## T37

The T37 event consisted of a single race. It was won by Mohamed Charmi, representing Tunisia.

### Final Round

20 September 2004, 19:45
| Rank | Athlete | Time | Notes |
| | Mohamed Charmi (TUN) | 4:22.09 | WR |
| | Oleksandr Driha (UKR) | 4:25.42 | |
| | Khaled Hanani (ALG) | 4:26.05 | |
| 4 | Mariusz Tubielewicz (POL) | 4:27.05 | |
| 5 | Micha Janse (NED) | 4:38.83 | |
| 6 | Kasper Nordlinder (SWE) | 4:44.93 | |
| 7 | Benny Govaerts (BEL) | 4:45.86 | |
| 8 | Rezki Reguig (ALG) | 4:48.03 | |
| 9 | Carlos Fernandez (ESP) | 4:55.41 | |
| 10 | Kang Sung Kook (KOR) | 5:03.80 | |
| 11 | Gaston Torres (ARG) | 5:15.51 | |
# Hank Williams (disambiguation)

Hank Williams (1923–1953) was an American singer-songwriter and musician.
Hank Williams may also refer to:
* Hank Williams Jr. (born 1949), American country singer-songwriter and musician, son of Hank Williams Sr.
* Hank Williams III (born 1972), singer, drummer, bassist, and guitarist, son of Hank Williams Jr.
* Hank Williams (basketball) (born 1952), American professional basketball player
# Don River (Tasmania)

The Don River is a perennial river for most of its length, located in the north-western region of Tasmania, Australia.

## Location and features

The river rises in West Kentish near Sheffield and flows generally north into Bass Strait at Devonport. The river descends 343 metres (1,125 ft) over its 37.8-kilometre (23.5 mi) course.