OpenLLM-France/wikimedia huggingface dataset:
# Sacubitril

Sacubitril (/səˈkjuːbɪtrɪl/; INN) is an antihypertensive drug used in combination with valsartan. The combination drug sacubitril/valsartan, known during trials as LCZ696 and marketed under the brand name Entresto, is a treatment for heart failure. It was approved under the FDA's priority review process for use in heart failure on July 7, 2015.

## Side effects

Sacubitril increases levels of bradykinin, which is responsible for the edema seen sometimes in patients with the medication. This is why the medication is not recommended for patients with a history of pulmonary edema with the usage of ACE inhibitors.

## Mechanism of action

Sacubitril is a prodrug that is activated to sacubitrilat (LBQ657) by de-ethylation via esterases. Sacubitrilat inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure–lowering peptides that work mainly by reducing blood volume. In addition, neprilysin degrades a variety of peptides including bradykinin, an inflammatory mediator.

## Synthesis

The large scale synthesis of sacubritil begins with 4-bromo-1,1'-biphenyl, which is converted to its corresponding Grignard reagent; this is reacted directly with (S)-epichlorohydrin regioselectively at less-substituted site of the epoxide.
A Mitsunobu reaction with succinimide is performed, followed by acidic hydrolysis of the succinimide protecting group, hydrolysis of the alkyl chloride using sodium hydroxide and protection of the free amine with a tert-butoxycarbonyl (Boc) group. The primary alcohol is oxidized using bleach with TEMPO as the catalyst. This aldehyde undergoes a Wittig reaction to for the α.β-unsaturated ester, which is converted to the lithium carboxylate by hydrolysis using lithium hydroxide in aqueous ethanol. Asymmetric hydrogenation using a ruthenium catalyst and a chiral bisphosphine ligand sets the second stereocenter. The carboxylate is esterified by reaction with thionyl chloride to form the acyl chloride, which is reacted with ethanol. The acidic conditions under which the acyl chloride is generated result in removal of the Boc group, which allows for direct reaction of the amine with succinic anhydride in the presence of pyridine as a base.
    Industrial scale synthetic route to sacubitril
# Ubayama Shell Mound

The Ubayama Shell Mound (姥山貝塚, Ubayama kaizuka) is an archaeological site in the Kashiwai neighborhood of the city of Ichikawa, Chiba Prefecture, in the Kantō region of Japan, containing a mid-to-late Jōmon period shell midden, designated a National Historic Site of Japan in 1967.
During the early to middle Jōmon period (approximately 4000 to 2500 BC), sea levels were five to six meters higher than at present, and the ambient temperature was two degrees Celsius higher. During this period, the Kantō region was inhabited by the Jōmon people, many of whom lived in coastal settlements. The middens associated with such settlements contain bone, botanical material, mollusc shells, sherds, lithics, and other artifacts and ecofacts associated with the now-vanished inhabitants, and these features, provide a useful source into the diets and habits of Jōmon society. Most of these middens are found along the Pacific coast of Japan.
The Ubayama site is located on the left bank of the Ohashiwa River, which flows into Tokyo Bay, on a plateau with an elevation of about 24 meters above the present sea level. The midden is horseshoe-shaped, measuring approximately 130 meters from east-to-west and 120 meters from north-to-south, forming an incomplete shell ring. The presence of a shell mound in this location was known at a relatively early time, and a preliminary survey was first made in 1893.
It was first excavated in 1926 by Tokyo Imperial University, at which time a group of 20 pit dwellings indicating the existence of a settlement were discovered. Five sets of human bones (two adult males, two adult females, and one child) were excavated from one of pit dwelling sites, believed to be members of the same family group. This was the first excavation of a Jōmon period settlement associated with a shell midden. Further excavations found a total of 39 pit dwellings and 143 sets of human remains, along with large quantities of Jōmon pottery.
The midden contained shells from more than 30 species of clams, and was used about 5000 years to 3000 years ago. The bones of fugu puffer fish have also been found in the midden, indicating that this fish was part of the Japanese diet since the Jōmon period, although there is no evidence that the family group found in the 1926 excavation died of tetrodotoxin poisoning. The excavated items from this site are stored at the University of Tokyo, Nanzan University, Meiji University, and other locations, and are also exhibited at the Ichikawa Archeology Museum, which was built adjacent to the Horinouchi Shell Mound, also in the city of Ichikawa.
The site is maintained as the Ubayama Kaizuka Park (姥山貝塚公園Ubayama kaizuka kōen), and it is located about ten minutes on foot from Funabashihōten Station on the JR East Musashino Line.
# Royal jelly (disambiguation)

Royal jelly is a substance secreted by honey bees to aid in the development of immature or young bees.
Royal jelly may also refer to:
* "Royal Jelly" (short story), a short story by Roald Dahl
* Jaymz Bee and the Royal Jelly Orchestra, a Canadian lounge music and jazz band
* Royal Jelly, an album by American rock singer Johnny Edwards
# 2007–08 Asia League Ice Hockey season

The 2007–08 Asia League Ice Hockey season was the fifth season of Asia League Ice Hockey. Seven teams participated in the league, and the Oji Eagles won the championship.

## Regular season

| | Club | GP | W | OTW | T | OTL | L | GF–GA | Pts |
| 1. | Seibu Prince Rabbits | 30 | 20 | 0 | 1 | 0 | 9 | 138–73 | 61 |
| 2. | High1 | 30 | 17 | 2 | 1 | 2 | 8 | 118–89 | 58 |
| 3. | Oji Eagles | 30 | 17 | 1 | 2 | 2 | 8 | 112–74 | 57 |
| 4. | Nippon Paper Cranes | 30 | 15 | 1 | 2 | 1 | 11 | 97–85 | 50 |
| 5. | Anyang Halla | 30 | 13 | 1 | 2 | 1 | 13 | 93–92 | 44 |
| 6. | Nikkō Ice Bucks | 30 | 8 | 2 | 2 | 0 | 18 | 60–109 | 30 |
| 7. | China Sharks | 30 | 3 | 0 | 0 | 1 | 26 | 63–159 | 10 |

## Playoffs

| Pre-Playoffs | Pre-Playoffs | Pre-Playoffs | Semifinals | Semifinals | Semifinals | Final | Final | Final |
| | | | 2 | High1 | 0 | | | |
| 3 | Oji Eagles | 3 | 3 | Ōji Eagles | 3 | | | |
| 6 | Nikkō Ice Bucks | 0 | | | | 3 | Oji Eagles | 3 |
| | | | | | | 4 | Nippon Paper Cranes | 0 |
| | | | 1 | Seibu Prince Rabbits | 1 | | | |
| 4 | Nippon Paper Cranes | 3 | 4 | Nippon Paper Cranes | 3 | | | |
| 5 | Anyang Halla | 0 | | | | | | |
# Manandhar

Manandhar is a surname. Notable people with the surname include:
* Asta Narayan Manandhar (1900–1960), Nepalese entrepreneur
* Baikuntha Manandhar (born 1951), Nepali marathon runner
* Basanta Prasad Manandhar, Nepalese politician
* Evana Manandhar, Nepalese businesswoman
* Karishma Manandhar, Nepalese actress
* Kiran Manandhar (born 1957), Nepalese painter
* Melina Manandhar (born 1975), Nepalese actress
* Narayan Manandhar (born 1981), Nepalese footballer
* Ram Bir Manandhar, Nepalese politician
* Shanta Das Manandhar (1934–2023), Nepalese writer
* Shashikala Manandhar (born 1960), Nepalese novelist
* Sonika Manandhar (born 1990), Nepali computer engineer
* Sulochana Manandhar (born 1955), Nepali poet
# Liu Weishan

Weishan Liu (劉維姍) is a guzheng (Chinese zither) master performer, composer and educator, based in San Francisco, California, United States. She studied at the Shenyang Conservatory of Music from 1949 onwards.
# Buddy Moreno

Carlos Jesus "Buddy" Moreno (July 14, 1912 – November 29, 2015) was an American musician during the swing era and radio and television personality.
In his book, The Big Bands, jazz writer George T. Simon described Moreno as "a grinning, seemingly ever-joyous guitarist ... who on novelty and uptempoed [sic] tunes projected a pleasant personality and voice to match."
Moreno was born in Los Angeles, California, as the only child to a Spanish father and an Irish mother. He was reported to be a cousin of actress Rita Moreno. He attended the University of California before leaving to join the orchestra of Anson Weeks.
His career began in 1929 when he sang in a vocal group. His big breakthrough came in 1933 when he joined Griff Williams's band in San Francisco as a singer and guitar player. Later he became a part of popular bandleader Dick Jurgens' orchestra. Moreno and Jurgens recorded many songs through the label Okeh Records, charting the number one hit "One Dozen Roses" in 1942. Moreno changed band once more, in 1943, when he joined Harry James' band.
Moreno appeared in the films Two Girls and a Sailor (1944) and Bathing Beauty (1944) along with the rest of the band. He formed his own band in 1947 with his wife, singer Perri Mitchell and others.
Beginning June 30, 1958, Moreno had a local television program, The Buddy Moreno Show, on KMOX-TV in St. Louis, Missouri.
He relocated to St. Louis in the 1950s, when his band was selected to be the house band in The Chase Park Plaza Hotel's Chase Club, which led to a national radio program, Saturdays at the Chase. As he approached his 60s, he switched to radio and worked for the local stations WIL-FM, WEW and WSIE.
In the 1960s, Moreno traveled with Bob Hope to entertain American military personnel around the world.

## Personal life

In 1950, Moreno wed Perri Mitchell, whom he had hired as a singer for his band in 1947. They were married until her death in 1998.

## Death

Moreno died at a Florissant, Missouri, assisted-living facility on November 29, 2015, at the age of 103. He was buried at Jefferson Barracks National Cemetery.
# Checker

Checker or chequer or variant, may refer to:

## People

* Chubby Checker (born 1941), American singer-songwriter best known for popularizing The Twist
* Emma Checker (born 1996), Australian footballer

## Arts, entertainment, and media

* Checker, a game piece in the board game Checkers (UK: draughts)
* Checker Records, a record label

## Brands and enterprises

* Checker Motors Corporation, built Checker taxis
* Checker Taxi, a taxi service founded by Morris Markin

## Other uses

* Check (pattern), also called checker or checkered, a pattern consisting of squares of alternating colors
* Checker, the action that produces checkering, a surface applied to wooden gunstocks to provide a non-slip grip (see Gunsmith)
* Another term for retail clerk.
# Rhaphidophyton

Rhaphidophyton is a monotypic genus of flowering plants belonging to the family Amaranthaceae. The only species is Rhaphidophyton regelii.
Its native range is Kazakhstan and Kyrgyzstan in Central Asia.
# Chrysotus subcostatus

Chrysotus subcostatus is a species of long-legged fly in the family Dolichopodidae.
# SG Waspo'98 Hannover

The Waspo 98 Hannover is a swimming and professional water polo club in Hannover, Germany. The club was founded in 2003 by the fusion of the former German champions Waspo Hannover-Linden 1913 and Wasserfreunde 98 Hannover.
# EPU

EPU or Epu may refer to:

## Universities

* Eastern Palm University, in Orlu, Nigeria
* Electric Power University, in Hanoi, Vietnam
* Erbil Polytechnic University, in Erbil, Iraqi Kurdistan
* European Peace University, in Stadtschlaining, Austria
* European Polytechnical University, in Pernik, Bulgaria

## Other uses

* Emergency power unit
* European Payments Union, a defunct trade union
* European Parliamentary Union, a defunct political organization
* European Party of Ukraine, a political party in Ukraine
* Pärnu Airport, in Estonia
* Epu, now Jeppo, a village in Finland
# Bilene

Bilene, also known as Praia do Bilene, is a town in southern Mozambique, lying 140 kilometres northeast of Maputo in the province of Gaza. It is known as a beach resort, lying on the Mozambique Channel. Noted for its calm and clear lagoon, the Uembje Lagoon, giving way to the pounding Indian Ocean beyond tall dunes, it is reported to be the closest beach destination to the city of Johannesburg in neighboring South Africa.

## Transportation

The town has an airport called Bilene Airport, currently disused.

## Tourism

Popular tourist activities in Bilene include sailing, canoeing, windsurfing, snorkelling, paragliding and kite surfing.
# Local Motion (company)

Local Motion, Inc. ("Local Motion") is a transportation software and hardware company that builds intelligent networks of shareable vehicles. Founded by John Stanfield and Clément Gires in 2010, the company is based in San Mateo, CA.

## History

Co-founders John Stanfield and Clément Gires met at Stanford University in 2010 while pursuing master's degrees. Stanfield previously co-founded two small businesses, Perfect Shine and Veggie Wheels. As his master's thesis project for the Joint Program in Design, he and several classmates designed and built a low-speed electric vehicle, which they called the Weng (short for "Where Everyone Needs to Go"). Gires also had previous experience in vehicle design, having helped to build a 1000 mpg car in France.
After graduation, Stanfield and Gires worked together to build a second low-speed electric vehicle as part of the Lemnos Labs hardware incubator program in San Francisco. The newer version of the Weng was designed to be shareable and interactive as well as energy efficient.
In 2012, the company changed its name from Weng Motors, Inc. to Local Motion, Inc., and switched its focus from designing vehicles to building software and hardware capable of connecting existing vehicles to local transportation networks. In the summer of 2012, the company began targeting fleets on corporate campuses as an initial sales channel, launching pilot networks on several corporate campuses in Silicon Valley.

## Product

Local Motion builds software and hardware designed to connect vehicles of all types to local networks. These networks are intended to increase the efficiency and usage of vehicles and facilitate fleet management and ride sharing. Local Motion aims to distinguish itself from competitors by focusing on two-way information flow and interactivity between users and vehicles. Gires defines the company's approach to transportation as providing both "information and service."
The company retrofits existing vehicles with hardware that interacts with users and other vehicles, gathers data about transportation patterns and user behavior, and transmits charge, health and location information back to the central network. The online booking platform lets users view schedules, book reservations and share rides. A separate platform allows fleet managers to monitor the status of vehicles, add or remove vehicles and users, oversee repairs, and resize or redistribute their fleets based on usage patterns.
# Michael T. Cahill

Michael T. Cahill is an American legal scholar who is a Professor of Law at Brooklyn Law School. He was also the former co-Dean of Rutgers Law School.

## Early life and education

Raised in Pompton Plains, New Jersey, Cahill graduated from Pequannock Township High School.
Cahill received a B.A. with distinction in Ethics, Politics & Economics from Yale University in 1993. He received his J.D., magna cum laude, in 1999 from the University of Michigan Law School, and also received a master of public policy (M.P.P.) degree in 1999 from the University of Michigan School of Public Policy. In law school, he served as a note editor for the Michigan Law Review and was given a Bodman-Longley Award for 1996-1997, "in recognition of [his] "superior scholastic record" and [his] contributions to the Michigan Law Review." He then served as a law clerk to Judge James B. Loken of the U.S. Court of Appeals for the Eighth Circuit from 1999 to 2000.

## Career

He taught at Chicago-Kent College of Law as a visiting assistant professor of law from 2002 to 2003.
Cahill taught and worked at Brooklyn Law School from 2003 until 2016, serving as Associate Dean for Academic Affairs from 2010 to 2013 and as Vice Dean from 2013 to 2015. Over that time, Cahill was involved in nearly every aspect of the school’s operation, including curricular oversight and reform, support for faculty research, admissions and financial-aid policy, budgetary planning, supervision of administrators and staff, maintenance and improvement of Law School facilities, external relations, and fundraising.
He served as co-dean and professor at Rutgers Law School from 2016 to 2019, taking the post at 44 years of age.
Cahill returned to Brooklyn Law School in 2019 to become President and Joseph Crea Dean, as well as a tenured Professor of Law on the faculty. He is the ninth dean in the law school’s 118-year history. One of his primary goals is to expand Brooklyn Law School's non-J.D. offerings to offer other programs, such as master’s degrees and certificates. His other goals center on ensuring the ongoing strength of the J.D. program, and emphasizing fundraising.
His scholarly background centers on criminal law. Cahill has also written about health law and policy. He has published a number of articles and book chapters in various venues, and has co-authored three books on criminal law with University of Pennsylvania Law School law professor Paul H. Robinson: the one-volume treatise Criminal Law (Aspen Treatise Series, 2d ed. 2012); Law Without Justice: Why Criminal Law Doesn't Give People What They Deserve (Oxford, 2006); and the student casebook Criminal Law: Case Studies and Controversies (Wolters Kluwer, 4th ed. 2016; with Shima Baradaran Baughman).

## Personal life

Cahill lives in Boerum Hill, Brooklyn with his wife, Rosalyn Scaff and two children.
# Warren McSkimming

Warren Charles McSkimming (born 21 June 1979) is a New Zealand former professional cricketer. He played for the Otago cricket team between the 1999–00 season and 2011–12, making more than 170 senior appearances for the side.
McSkimming was born at Ranfurly in Central Otago in 1979 and educated at Waitaki Boys' High School. His father, Bryan McSkimming, had played Hawke Cup cricket for Central Otago and had played in the Otago provincial side's Second XI.
A medium-paced bowler who focussed "more on accuracy, rather than bounce or pace, McSkimming played age-group cricket for Otago from the 1996–97 season and played three youth One Day Internationals for the New Zealand under-19 side against an England under-19 side in early 1999. He went on to make his senior representative debut for Otago in December of the same year, playing a List A against Canterbury, opening the bowling without taking a wicket and scoring two not out. He made his first-class debut later the same season, taking five wickets for Otago against the same side.
McSkimming went on to play regularly for Otago in a career which last until the end of the 2010–11 season. He took 240 first-class and 117 List A wickets and made a first-class century, a score of 111 runs made as part of an Otago record ninth wicket partnership of 208 runs with Bradley Scott against Auckland in 2004–05. He played for the New Zealand A side four times, touring Sri Lanka with the side in 2005 and playing against a touring England side in 2008–09. Although he was never capped by the national side, he was selected in the 30-man preliminary New Zealand squad for the Champions Trophy in 2006.
# Burtness

Burtness is a surname. Notable people with the surname include:
* Barbara Burtness, American internist and oncologist
* Carl S. Burtness (1882-1954), American farmer, businessman, politician
* Harold W. Burtness (1897–1978), American railroad executive
* Olger B. Burtness (1884–1960), American politician and judge
# Holly Newman

Holly Newman (born 1974 in Lytham St Annes), is an English actress who played Lorraine Brownlow in Coronation Street. She has also appeared in Dalziel and Pascoe, Crossroads, Holby City, and Kiss Me Kate.
# SH-053-R-CH3-2′F

SH-053-R-CH3-2′F is a drug used in scientific research which is a benzodiazepine derivative. It produces some of the same effects as other benzodiazepines, but is much more subtype-selective than most other drugs of this class, having high selectivity, binding affinity and efficacy at the α$_5$ subtype of the GABA$_A$ receptor. This gives much tighter control of the effects produced, and so while SH-053-R-CH3-2′F retains sedative and anxiolytic effects, it does not cause ataxia at moderate doses. SH-053-R-CH3-2′F also blocks the nootropic effects of the α$_5$-selective inverse agonist PWZ-029, so amnesia is also a likely side effect.
Replacement of the ester function by an amide, realized in analogs such as MP-III-022 and GL-II-73, improves selectivity, efficacy, and kinetic behavior.
# Ding Desun

Ding Desun is a fictional character in Water Margin, one of the Four Great Classical Novels in Chinese literature. Nicknamed "Arrow-hit Tiger", he ranks 79th among the 108 Stars of Destiny and 43rd among the 72 Earthly Fiends.

## Background

Ding Desun is nicknamed "Arrow-hit Tiger" as his face and body bear multiple scars. A good fighter, he uses a forked spear which he sometimes hurls to kill. Together with Gong Wang, he is a lieutenant of Zhang Qing, the garrison commandant of Dongchang (東昌府; in present-day Liaocheng, Shandong).

## Joining Liangshan

With his deadly stone-flinging skill, Zhang Qing keeps at bay a force from Liangshan Marsh under Lu Junyi that has come to seize the grain stocks of Dongchang. Song Jiang, who has just overrun Dongping prefecture, comes to reinforce Lu with his force. Zhang Qing further injures some of Liangshan's best warriors with his stones as they take turns fighting him on horseback or on foot. Ding Desun and Gong Wang stay in the wings preparing to capture any one whom Zhang fells.
When Zhang Qing and Dong Ping grapple with each other on horseback, with their spears discarded, Ding Desun moves in to intercept Lü Fang and Guo Sheng as they rush to Dong's help. Ding manages to hold his own against the two. But Yan Qing fires an arrow hitting his horse in the leg, causing it to throw off its rider, who is then captured. Ding and Gong Wang, is also taken, beaten by Lin Chong and Hua Rong, are sent in captivity back to Liangshan. After Zhang Qing is captured and won over by Liangshan, Ding and Gong also join Liangshan.

## Campaigns and death

Ding Desun is appointed as one of the leaders of the Liangshan infantry after the 108 Stars of Destiny came together in what is called the Grand Assembly. He participates in the campaigns against the Liao invaders and rebel forces in Song territory following amnesty from Emperor Huizong for Liangshan.
In the first attack on Shezhou in the campaign against Fang La, Lu Junyi is defeated and orders his men to withdraw some distance from the city. Zhu Wu suggests setting up an ambush as the enemy would launch a sneak attack. The enemy comes and is routed. But in pursuing them, Ding Desun is bitten by a poisonous snake in a bush and dies.
# Margaret Rickert

Margaret Rickert (May 5, 1888 – 1973) was an American art historian and World War II codebreaker. In 1954, she became the first American and first woman to author a volume in the original series of the Pelican History of Art with her title, Painting in Britain: The Middle Ages. She was the sister of art historian Edith Rickert.
Born in 1888, Richert earned her Ph.D. from the University of Chicago in 1938. Her dissertation was on the reconstruction of an English Carmelite missal from a scrapbook housed in the British Museum. In 1952, she published a book based on this dissertation.
During World War II, Rickert worked as a codebreaker for the U.S. Army Signal Corps in Washington, D.C.
Rickert died in 1973. Her papers are housed at the University of Chicago Library.

## Published works

* Rickert, Margaret J. Painting in Britain: The Middle Ages. Baltimore: Penguin Books, 1963.
* Rickert, Margaret J, and Philip A. Hanrott. The Reconstructed Carmelite Missal: An English Manuscript of the Late XIV Century in the British Museum (additional 29704-5, 44892). London: Faber and Faber, 1952.
* Rickert, Margaret J. The So-Called Beaufort Hours and York Psalter. London, 1962.