# 2021 Open Ciudad de Valencia – Singles

Varvara Gracheva was the defending champion but chose to participate at the 2021 J&T Banka Ostrava Open instead.
Arantxa Rus won the title, defeating Mihaela Buzărnescu in the final, 6–4, 7–6$^{(7–3)}$.

## Seeds

* Arantxa Rus (champion)
* Martina Trevisan (withdrew)
* Sara Errani (withdrew)
* Irina Bara (quarterfinals)
* Kristína Kučová (first round)
* Dalma Gálfi (first round, retired)
* Ekaterine Gorgodze (first round)
* Francesca Jones (quarterfinals)
* Aliona Bolsova (semifinals)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| 1 | Arantxa Rus | 7$^7$ | 6 | | | | |
| | Seone Mendez | 6$^3$ | 2 | | | | |
| | Seone Mendez | 6$^3$ | 2 | 1 | Arantxa Rus | 6 | 7$^7$ |
| | | | | | Mihaela Buzărnescu | 4 | 6$^3$ |
| | Mihaela Buzărnescu | 6 | 6 | | Mihaela Buzărnescu | 4 | 6$^3$ |
| 9 | Aliona Bolsova | 4 | 2 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | A Rus | 6 | 6 | | | | | | | | | | | | | | | |
| Q | IG Ghioroaie | 3 | 1 | | 1 | A Rus | 6 | 6 | | | | | | | | | | |
| | V Cepede Royg | 3 | 7$^7$ | 2 | Q | I Shymanovich | 3 | 4 | | | | | | | | | | |
| Q | I Shymanovich | 6 | 6$^4$ | 6 | | | | | | 1 | A Rus | 6 | 6 | | | | | |
| WC | Á Fita Boluda | 6 | 6 | | | | | | | | D Seguel | 4 | 1 | | | | | |
| WC | R Masarova | 1 | 3 | | WC | Á Fita Boluda | 4 | 7$^7$ | 1 | | | | | | | | | |
| | D Seguel | 6 | 6$^4$ | 6 | | D Seguel | 6 | 6$^1$ | 6 | | | | | | | | | |
| 7 | E Gorgodze | 4 | 7$^7$ | 2 | | | | | | | | | | | 1 | A Rus | 7$^7$ | 6 |
| 4 | I Bara | 6 | 6 | | | | | | | | | | | | | S Mendez | 6$^3$ | 2 |
| LL | A Carreras | 4 | 3 | | 4 | I Bara | 4 | 6 | 6 | | | | | | | | | |
| | C Paquet | 6 | 7$^7$ | | | C Paquet | 6 | 4 | 4 | | | | | | | | | |
| | I Burillo Escorihuela | 1 | 6$^5$ | | | | | | | 4 | I Bara | 3 | 7$^{10}$ | 4 | | | | |
| | S Mendez | 6 | 6 | | | | | | | | S Mendez | 6 | 6$^8$ | 6 | | | | |
| | S Waltert | 3 | 0 | | | S Mendez | 6 | 6 | | | | | | | | | | |
| Q | L Romero Gormaz | 3 | | | Q | L Romero Gormaz | 0 | 2 | | | | | | | | | | |
| 6 | D Gálfi | 1$^r$ | | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 5 | K Kučová | 7$^7$ | 3 | 3 | | | | | | | | | | | | | |
| Q | A Prisăcariu | 6$^4$ | 6 | 6 | Q | A Prisăcariu | 0 | 1 | | | | | | | | | |
| | P Ormaechea | 3 | 6$^3$ | | | M Buzărnescu | 6 | 6 | | | | | | | | | |
| | M Buzărnescu | 6 | 7$^7$ | | | | | | | | M Buzărnescu | 6 | 6 | | | | |
| WC | A Gámiz | 4 | 7$^{11}$ | 7$^7$ | | | | | | WC | A Gámiz | 2 | 3 | | | | |
| Q | M Bassols Ribera | 6 | 6$^9$ | 6$^4$ | WC | A Gámiz | 7 | 7 | | | | | | | | | |
| WC | J Bouzas Maneiro | 2 | 2 | | LL | E Guerrero Álvarez | 5 | 5 | | | | | | | | | |
| LL | E Guerrero Álvarez | 6 | 6 | | | | | | | | | | | | M Buzărnescu | 6 | 6 |
| 8 | F Jones | 6 | 6 | | | | | | | | | | | 9 | A Bolsova | 4 | 2 |
| Q | N Bains | 3 | 1 | | 8 | F Jones | 7$^8$ | 6 | | | | | | | | | |
| JE | D Parry | 3 | 3 | | | D Papamichail | 6$^6$ | 1 | | | | | | | | | |
| | D Papamichail | 6 | 6 | | | | | | | 8 | F Jones | 6$^4$ | 1 | | | | |
| Q | M Gutiérrez Carrasco | 6 | 0 | 6 | | | | | | 9 | A Bolsova | 7$^7$ | 6 | | | | |
| | Ç Büyükakçay | 2 | 6 | 4 | Q | M Gutiérrez Carrasco | 7$^7$ | 4 | 0 | | | | | | | | |
| Q | F Kozaki | 2 | 2 | | 9 | A Bolsova | 6$^5$ | 6 | 6 | | | | | | | | |
| 9 | A Bolsova | 6 | 6 | | | | | | | | | | | | | | |