# 2021 Lima Challenger II – Singles

Hugo Dellien was the defending champion but lost in the quarterfinals to Juan Manuel Cerúndolo.
Nicolás Jarry won the title after defeating Cerúndolo 6–2, 7–5 in the final.

## Seeds

* Thiago Monteiro (withdrew)
* Juan Manuel Cerúndolo (final)
* Daniel Elahi Galán (first round)
* Francisco Cerúndolo (withdrew)
* Sebastián Báez (withdrew)
* Thiago Seyboth Wild (second round)
* Hugo Dellien (quarterfinals)
* Juan Pablo Varillas (semifinals)
* Tomás Martín Etcheverry (quarterfinals)
* Marcelo Tomás Barrios Vera (quarterfinals)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| | Vít Kopřiva | 3 | 3 | | | | | |
| | Nicolás Jarry | 6 | 6 | | | | | |
| | Nicolás Jarry | 6 | 6 | | | Nicolás Jarry | 6 | 7 |
| | | | | | 2 | Juan Manuel Cerúndolo | 2 | 5 |
| 8 | Juan Pablo Varillas | 5 | 6 | 3 | 2 | Juan Manuel Cerúndolo | 2 | 5 |
| 2 | Juan Manuel Cerúndolo | 7 | 1 | 6 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals |
| 10 | MT Barrios Vera | 6 | 6 | | | | | | | | | | | | | |
| Q | H Casanova | 4 | 2 | | 10 | MT Barrios Vera | 7 | 6 | | | | | | | | |
| | D Kuzmanov | 5 | 1 | | Q | G Villanueva | 5 | 1 | | | | | | | | |
| Q | G Villanueva | 7 | 6 | | | | | | 10 | MT Barrios Vera | 4 | 6 | 0 | | | |
| | V Kopřiva | 6 | 4 | 6 | | | | | | V Kopřiva | 6 | 1 | 6 | | | |
| | R Olivo | 1 | 6 | 3 | | V Kopřiva | 6 | 6 | | | | | | | | |
| Alt | N Mejía | 2 | 4 | | 6 | T Seyboth Wild | 4 | 3 | | | | | | | | |
| 6 | T Seyboth Wild | 6 | 6 | | | | | | | | | | | V Kopřiva | 3 | 3 |
| 3 | DE Galán | 3 | 5 | | | | | | | | | | | N Jarry | 6 | 6 |
| LL | C Rodríguez | 6 | 7 | | LL | C Rodríguez | 3 | 6$^3$ | | | | | | | | |
| WC | A Huertas del Pino | 5 | 0 | | | N Jarry | 6 | 7$^7$ | | | | | | | | |
| | N Jarry | 7 | 6 | | | | | | | N Jarry | 7$^8$ | 6 | | | | |
| PR | G Melzer | 6 | 6 | | | | | | | A Tabilo | 6$^6$ | 2 | | | | |
| LL | Jean Thirouin | 3 | 1 | | PR | G Melzer | 3 | 3 | | | | | | | | |
| | A Tabilo | 6 | 6 | | | A Tabilo | 6 | 6 | | | | | | | | |
| Q | A Lazarov | 1 | 4 | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 8 | JP Varillas | 6 | 6 | | | | | | | | | | | | | | | |
| Alt | P Krstin | 3 | 1 | | 8 | JP Varillas | 6 | 6 | | | | | | | | | | |
| | A Collarini | 6 | 6 | | | A Collarini | 2 | 1 | | | | | | | | | | |
| Q | J Pospíšil | 1 | 4 | | | | | | 8 | JP Varillas | 6 | 6 | | | | | | |
| | J de Jong | 2 | 7$^7$ | 7$^7$ | | | | | 9 | TM Etcheverry | 4 | 4 | | | | | | |
| Alt | R Quiroz | 6 | 6$^4$ | 6$^5$ | | J de Jong | 5 | 4 | | | | | | | | | | |
| | JP Ficovich | 5 | 6 | 4 | 9 | TM Etcheverry | 7 | 6 | | | | | | | | | | |
| 9 | TM Etcheverry | 7 | 2 | 6 | | | | | | | | | | 8 | JP Varillas | 5 | 6 | 3 |
| 7 | H Dellien | 0 | 6 | 6 | | | | | | | | | | 2 | JM Cerúndolo | 7 | 1 | 6 |
| Alt | G Oliveira | 6 | 2 | 2 | 7 | H Dellien | 6 | 6 | | | | | | | | | | |
| | N Kicker | 4 | 7$^7$ | 6 | | N Kicker | 2 | 0 | | | | | | | | | | |
| WC | N Álvarez | 6 | 6$^4$ | 2 | | | | | 7 | H Dellien | 6$^4$ | 7$^7$ | 4 | | | | | |
| WC | C Huertas del Pino | 3 | 4 | | | | | | 2 | JM Cerúndolo | 7$^7$ | 6$^5$ | 6 | | | | | |
| LL | A Galarneau | 6 | 6 | | LL | A Galarneau | 5 | 4 | | | | | | | | | | |
| Alt | O Luz | 6 | 1 | 4 | 2 | JM Cerúndolo | 7 | 6 | | | | | | | | | | |
| 2 | JM Cerúndolo | 4 | 6 | 6 | | | | | | | | | | | | | | |