# 2021 Open Bogotá – Singles

Marcelo Arévalo was the defending champion but chose not to defend his title.
Gerald Melzer won the title after defeating Facundo Mena 6–2, 3–6, 7–6$^{(7–5)}$ in the final.

## Seeds

* Daniel Elahi Galán (second round)
* Daniel Altmaier (second round)
* Vít Kopřiva (first round)
* Nicolás Jarry (first round)
* Facundo Mena (final)
* Jesper de Jong (semifinals)
* Ulises Blanch (first round)
* Malek Jaziri (first round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final | Final |
| PR | Gerald Melzer | 6 | 6$^5$ | 6 | | | | | |
| Q | Nicolás Barrientos | 2 | 7$^7$ | 1 | | | | | |
| Q | Nicolás Barrientos | 2 | 7$^7$ | 1 | PR | Gerald Melzer | 6 | 3 | 7$^7$ |
| | | | | | 5 | Facundo Mena | 2 | 6 | 6$^5$ |
| 6 | Jesper de Jong | 6$^3$ | 5 | | 5 | Facundo Mena | 2 | 6 | 6$^5$ |
| 5 | Facundo Mena | 7$^7$ | 7 | | | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | DE Galán | 4 | 6 | 6 | | | | | | | | | | | | | | |
| | Matthieu Perchicot | 6 | 3 | 4 | 1 | DE Galán | 6$^5$ | 2 | | | | | | | | | | |
| | O Luz | 5 | 2 | | PR | G Melzer | 7$^7$ | 6 | | | | | | | | | | |
| PR | G Melzer | 7 | 6 | | | | | | | PR | G Melzer | 6 | 6 | | | | | |
| | N Mejía | 6 | 7 | | | | | | | | N Mejía | 0 | 4 | | | | | |
| | C Rodríguez | 1 | 5 | | | N Mejía | 6 | 7 | | | | | | | | | | |
| | L Catarina | 6 | 6 | | | L Catarina | 4 | 5 | | | | | | | | | | |
| 8 | M Jaziri | 2 | 3 | | | | | | | | | | | PR | G Melzer | 6 | 6$^5$ | 6 |
| 4 | N Jarry | 6 | 5 | 6$^5$ | | | | | | | | | | Q | N Barrientos | 2 | 7$^7$ | 1 |
| Q | E Couacaud | 3 | 7 | 7$^7$ | Q | E Couacaud | 3 | 4 | | | | | | | | | | |
| Q | N Barrientos | 2 | 6 | 6 | Q | N Barrientos | 6 | 6 | | | | | | | | | | |
| WC | JS Gómez | 6 | 2 | 4 | | | | | | Q | N Barrientos | 6 | 7 | | | | | |
| | G Oliveira | 3 | 6 | 6 | | | | | | | O Roca Batalla | 3 | 5 | | | | | |
| | P Krstin | 6 | 3 | 2 | | G Oliveira | 3 | 6 | 5 | | | | | | | | | |
| | O Roca Batalla | 6 | 6 | | | O Roca Batalla | 6 | 4 | 7 | | | | | | | | | |
| 7 | U Blanch | 3 | 2 | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 6 | J de Jong | 7$^7$ | 7$^7$ | | | | | | | | | | | | | | |
| | Pol Martín Tiffon | 6$^3$ | 6$^3$ | | 6 | J de Jong | 7$^7$ | 7$^8$ | | | | | | | | | |
| Alt | Matías Zukas | 4 | 6$^4$ | | | R Quiroz | 6$^5$ | 6$^6$ | | | | | | | | | |
| | R Quiroz | 6 | 7$^7$ | | | | | | | 6 | J de Jong | 6 | 7 | | | | |
| | Alexis Gautier | 2 | 1 | | | | | | | | M Pucinelli de Almeida | 2 | 5 | | | | |
| | M Pucinelli de Almeida | 6 | 6 | | | M Pucinelli de Almeida | 6$^3$ | 6 | 6 | | | | | | | | |
| | A González | 6 | 7$^7$ | | | A González | 7$^7$ | 1 | 2 | | | | | | | | |
| 3 | V Kopřiva | 2 | 6$^5$ | | | | | | | | | | | 6 | J de Jong | 6$^3$ | 5 |
| 5 | F Mena | 6 | 6 | | | | | | | | | | | 5 | F Mena | 7$^7$ | 7 |
| Q | L Castelnuovo | 4 | 2 | | 5 | F Mena | 6 | 6 | | | | | | | | | |
| WC | A Gómez | 6 | 3 | 7 | WC | A Gómez | 3 | 1 | | | | | | | | | |
| Q | J Pospíšil | 3 | 6 | 5 | | | | | | 5 | F Mena | 6 | 6 | | | | |
| | A Galarneau | 6 | 6 | | | | | | | | A Galarneau | 1 | 4 | | | | |
| WC | Enrique Peña | 1 | 1 | | | A Galarneau | 6 | 3 | 6 | | | | | | | | |
| | D Svrčina | 4 | 1 | | 2 | D Altmaier | 3 | 6 | 3 | | | | | | | | |
| 2 | D Altmaier | 6 | 6 | | | | | | | | | | | | | | |