# 2022 Città di Como Challenger – Singles

Juan Manuel Cerúndolo was the defending champion but chose not to defend his title.
Cedrik-Marcel Stebe won the title after defeating Francesco Passaro 7–6$^{(7–2)}$, 6–4 in the final.

## Seeds

* Marco Cecchinato (first round)
* Giulio Zeppieri (second round)
* Francesco Passaro (final)
* Nikola Milojević (first round)
* Matteo Arnaldi (semifinals, retired)
* Riccardo Bonadio (quarterfinals)
* Stefano Travaglia (first round)
* Andrea Arnaboldi (first round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| 5 | Matteo Arnaldi | 1 | 1$^r$ | | | | |
| | Cedrik-Marcel Stebe | 6 | 4 | | | | |
| | Cedrik-Marcel Stebe | 6 | 4 | | Cedrik-Marcel Stebe | 7$^7$ | 6 |
| | | | | 3 | Francesco Passaro | 6$^2$ | 4 |
| 3 | Francesco Passaro | 6 | 6 | 3 | Francesco Passaro | 6$^2$ | 4 |
| | Lukáš Klein | 4 | 1 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | M Cecchinato | 7$^7$ | 6$^2$ | 1 | | | | | | | | | | | | | | |
| | N Fatić | 6$^2$ | 7$^7$ | 6 | | N Fatić | 6 | 6 | | | | | | | | | | |
| | O Virtanen | 6 | 6$^2$ | 1$^r$ | Alt | L Miedler | 3 | 3 | | | | | | | | | | |
| Alt | L Miedler | 2 | 7$^7$ | 3 | | | | | | | N Fatić | 5 | 6 | 6$^4$ | | | | |
| | JB Torres | 1 | 7 | 3 | | | | | | 5 | M Arnaldi | 7 | 2 | 7$^7$ | | | | |
| Q | G Oradini | 6 | 5 | 6 | Q | G Oradini | 6 | 5 | 2 | | | | | | | | | |
| | V Sachko | 2 | 0$^r$ | | 5 | M Arnaldi | 2 | 7 | 6 | | | | | | | | | |
| 5 | M Arnaldi | 6 | 0 | | | | | | | | | | | | 5 | M Arnaldi | 1 | 1$^r$ |
| 4 | N Milojević | 6$^2$ | 5 | | | | | | | | | | | | | C-M Stebe | 6 | 4 |
| SE | Lucas Gerch | 7$^7$ | 7 | | SE | L Gerch | 6 | 3 | 2 | | | | | | | | | |
| | M Bašić | 4 | 0 | | | C-M Stebe | 4 | 6 | 6 | | | | | | | | | |
| | C-M Stebe | 6 | 6 | | | | | | | | C-M Stebe | 6 | 6 | | | | | |
| | A Giannessi | 6 | 3 | 0$^r$ | | | | | | LL | K de Schepper | 3 | 2 | | | | | |
| LL | K de Schepper | 4 | 6 | 1 | LL | K de Schepper | 5 | 6 | 7 | | | | | | | | | |
| Q | M Copil | 7$^7$ | 4 | 7$^7$ | Q | M Copil | 7 | 4 | 5 | | | | | | | | | |
| 8 | A Arnaboldi | 6$^4$ | 6 | 6$^2$ | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 7 | S Travaglia | 3 | 4 | | | | | | | | | | | | | | | |
| | M Zekić | 6 | 6 | | | M Zekić | 3 | 6 | 6$^5$ | | | | | | | | | |
| WC | M Gigante | 6$^4$ | 6 | 6 | WC | M Gigante | 6 | 3 | 7$^7$ | | | | | | | | | |
| | GM Moroni | 7$^7$ | 2 | 1 | | | | | | WC | M Gigante | 7$^7$ | 1 | 5 | | | | |
| | D Džumhur | 7 | 6 | | | | | | | 3 | F Passaro | 6$^4$ | 6 | 7 | | | | |
| Alt | O Krutykh | 5 | 3 | | | D Džumhur | 2 | 5 | | | | | | | | | | |
| Q | N Moreno de Alboran | 6$^5$ | 6 | 3 | 3 | F Passaro | 6 | 7 | | | | | | | | | | |
| 3 | F Passaro | 7$^7$ | 4 | 6 | | | | | | | | | | | 3 | F Passaro | 6 | 6 |
| 6 | R Bonadio | 6 | 6$^4$ | 7$^7$ | | | | | | | | | | | | L Klein | 4 | 1 |
| | G Villanueva | 4 | 7$^7$ | 6$^5$ | 6 | R Bonadio | 6 | 6 | | | | | | | | | | |
| Q | A Andreev | 6$^4$ | 6 | 3 | WC | F Arnaboldi | 2 | 3 | | | | | | | | | | |
| WC | F Arnaboldi | 7$^7$ | 1 | 6 | | | | | | 6 | R Bonadio | 6 | 2 | 4 | | | | |
| WC | G Ferrari | 6 | 1 | 4 | | | | | | | L Klein | 4 | 6 | 6 | | | | |
| | L Klein | 4 | 6 | 6 | | L Klein | 7$^7$ | 2 | 7$^{10}$ | | | | | | | | | |
| Q | C Crețu | 6$^1$ | 2 | | 2 | G Zeppieri | 6$^5$ | 6 | 6$^8$ | | | | | | | | | |
| 2 | G Zeppieri | 7$^7$ | 6 | | | | | | | | | | | | | | | |