# 2021 Potchefstroom Open – Singles

This was the second edition of the tournament. There was no defending champion as the tournament was canceled at the quarterfinals stage due to the COVID-19 pandemic.
Benjamin Bonzi won the title after defeating Liam Broady 7–5, 6–4 in the final.

## Seeds

* Prajnesh Gunneswaran (first round)
* Benjamin Bonzi (champion)
* Marc-Andrea Hüsler (first round)
* Jay Clarke (first round)
* Brayden Schnur (first round)
* Cem İlkel (semifinals)
* Peter Polansky (quarterfinals)
* Roberto Cid Subervi (first round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| 6 | Cem İlkel | 6$^3$ | 4 | | | | |
| Q | Liam Broady | 7$^7$ | 6 | | | | |
| Q | Liam Broady | 7$^7$ | 6 | Q | Liam Broady | 5 | 4 |
| | | | | 2 | Benjamin Bonzi | 7 | 6 |
| Q | Nick Chappell | 1 | 2 | 2 | Benjamin Bonzi | 7 | 6 |
| 2 | Benjamin Bonzi | 6 | 6 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | P Gunneswaran | 3 | 4 | | | | | | | | | | | | | | | |
| | D Kuzmanov | 6 | 6 | | | D Kuzmanov | 6 | 7 | | | | | | | | | | |
| Q | R Peniston | 6 | 4 | 4 | | E Benchetrit | 2 | 5 | | | | | | | | | | |
| | E Benchetrit | 4 | 6 | 6 | | | | | | | D Kuzmanov | 6 | 3 | 2 | | | | |
| WC | Khololwam Montsi | 3 | 1 | | | | | | | 6 | C İlkel | 4 | 6 | 6 | | | | |
| PR | J Cagnina | 6 | 6 | | PR | J Cagnina | 2 | 3 | | | | | | | | | | |
| PR | J Brooksby | 3 | 4 | | 6 | C İlkel | 6 | 6 | | | | | | | | | | |
| 6 | C İlkel | 6 | 6 | | | | | | | | | | | | 6 | C İlkel | 6$^3$ | 4 |
| 4 | J Clarke | 6$^5$ | 4 | | | | | | | | | | | | Q | L Broady | 7$^7$ | 6 |
| | U Blanch | 7$^7$ | 6 | | | U Blanch | 7$^7$ | 3 | 0$^r$ | | | | | | | | | |
| | C-h Tseng | 6 | 4 | 6 | | C-h Tseng | 6$^2$ | 6 | 2 | | | | | | | | | |
| | A Santillan | 1 | 6 | 3 | | | | | | | C-h Tseng | 3 | 3 | | | | | |
| | A Menéndez Maceiras | 6 | 6 | | | | | | | Q | L Broady | 6 | 6 | | | | | |
| | T Gabashvili | 4 | 4 | | | A Menéndez Maceiras | 4 | 6$^3$ | | | | | | | | | | |
| Q | L Broady | 6 | 6 | | Q | L Broady | 6 | 7$^7$ | | | | | | | | | | |
| 5 | B Schnur | 4 | 3 | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 7 | P Polansky | 6 | 3 | 7$^7$ | | | | | | | | | | | | | | |
| | V Galović | 2 | 6 | 6$^2$ | 7 | P Polansky | 6 | 6 | | | | | | | | | | |
| | T Lamasine | 7$^7$ | 1 | 6 | | T Lamasine | 4 | 4 | | | | | | | | | | |
| WC | Vaughn Hunter | 6$^1$ | 6 | 1 | | | | | | 7 | P Polansky | 4 | 7$^7$ | 4 | | | | |
| Q | N Chappell | 6 | 2 | 7$^7$ | | | | | | Q | N Chappell | 6 | 6$^3$ | 6 | | | | |
| | N Kuhn | 1 | 6 | 6$^3$ | Q | N Chappell | 6 | 6 | | | | | | | | | | |
| | H Grenier | 7$^7$ | 7 | | | H Grenier | 2 | 4 | | | | | | | | | | |
| 3 | M-A Hüsler | 6$^5$ | 5 | | | | | | | | | | | | Q | N Chappell | 1 | 2 |
| 8 | R Cid Subervi | 3 | 5 | | | | | | | | | | | | 2 | B Bonzi | 6 | 6 |
| | P Krstin | 6 | 7 | | | P Krstin | 1$^r$ | | | | | | | | | | | |
| Q | M Bašić | 7$^7$ | 7 | | Q | M Bašić | 4 | | | | | | | | | | | |
| | Z Kolář | 6$^4$ | 5 | | | | | | | Q | M Bašić | 3 | 1 | | | | | |
| WC | Robbie Arends | 2 | 2 | | | | | | | 2 | B Bonzi | 6 | 6 | | | | | |
| | R Quiroz | 6 | 6 | | | R Quiroz | 6 | 4 | 3 | | | | | | | | | |
| | G Blancaneaux | 2 | 4 | | 2 | B Bonzi | 3 | 6 | 6 | | | | | | | | | |
| 2 | B Bonzi | 6 | 6 | | | | | | | | | | | | | | | |