# List of human spaceflights, 2001–2010

This is a detailed list of human spaceflights from 2001 to 2010, including the first full era of the International Space Station, first Shenzhou flights and first commercial space flights.
* Red indicates fatalities.
* Green indicates a suborbital flight.
| # | Crew | Launch spacecraft | Habitation | Habitation | Return spacecraft | Brief mission summary |
| 224 | Kenneth D. Cockrell (4) Mark L. Polansky (1) Robert L. Curbeam (2) Marsha S. Ivins (5) Thomas D. Jones (4) | 7 February 2001 STS-98, Atlantis | ISS | ISS | 20 February 2001 STS-98, Atlantis | ISS assembly and supply. Delivery of Destiny Laboratory Module. |
| 225 | James D. Wetherbee (5) James M. Kelly (1) Andrew S. W. Thomas (3) Paul W. Richards | 8 March 2001 STS-102, Discovery | ISS | ISS | 21 March 2001 STS-102, Discovery | ISS crew rotation, outfitting and resupply. |
| 225 | Yury Usachev (4) James S. Voss (5) Susan Helms (5) | 8 March 2001 STS-102, Discovery | ISS (crew 2) | ISS (crew 2) | 22 August 2001 STS-105, Discovery | ISS crew rotation, outfitting and resupply. |
| 226 | Kent V. Rominger (5) Jeffrey S. Ashby (2) Scott E. Parazynski (4) John L. Phillips (1) Chris A. Hadfield (2) Umberto Guidoni (2) Yuri Lonchakov (1) | 19 April 2001 STS-100, Endeavour | ISS | ISS | 1 May 2001 STS-100, Endeavour | ISS supply and assembly: delivery of Canadarm2 robotic arm. First European on board ISS (Guidoni). First Canadian EVA (Hadfield). |
| 227 | Talgat Musabayev (3) Yuri Baturin (2) Dennis A. Tito | 29 April 2001 Soyuz TM-32 | ISS | ISS | 5 May 2001 Soyuz TM-31 | First paying space tourist (Tito). |
| 228 | Steven W. Lindsey (3) Charles O. Hobaugh (1) Michael L. Gernhardt (4) James F. Reilly (2) Janet L. Kavandi (3) | 12 July 2001 STS-104, Atlantis | ISS | ISS | 24 July 2001 STS-104, Atlantis | ISS assembly and maintenance: delivery of Quest Airlock |
| 229 | Scott J. Horowitz (4) Frederick W. Sturckow (2) Daniel T. Barry (3) Patrick G. Forrester (1) | 10 August 2001 STS-105, Discovery | ISS | ISS | 22 August 2001 STS-105, Discovery | ISS crew rotation, assembly and supply. |
| 229 | Frank L. Culbertson (3) Vladimir Dezhurov (2) Mikhail Tyurin (1) | 10 August 2001 STS-105, Discovery | ISS (crew 3) | ISS (crew 3) | 17 December 2001 STS-108, Endeavour | ISS crew rotation, assembly and supply. |
| 230 | Viktor Mikhaylovich Afanasyev (4) Konstantin Kozeyev Claudie Haigneré (2) | 21 October 2001 Soyuz TM-33 | ISS | ISS | 31 October 2001 Soyuz TM-32 | |
| 231 | Dominic L. Pudwill Gorie (3) Mark Kelly (1) Linda M. Godwin (4) Daniel M. Tani (1) | 5 December 2001 STS-108, Endeavour | ISS | ISS | 17 December 2001 STS-108, Endeavour | ISS crew rotation, assembly and supply. |
| 231 | Yuri Onufrienko (2) Carl E. Walz (4) Daniel W. Bursch (4) | 5 December 2001 STS-108, Endeavour | ISS (crew 4) | ISS (crew 4) | 19 June 2002 STS-111, Endeavour | ISS crew rotation, assembly and supply. |
| 232 | Scott D. Altman (3) Duane G. Carey John M. Grunsfeld (4) Nancy J. Sherlock Currie (4) James H. Newman (4) Richard M. Linnehan (3) Michael J. Massimino (1) | 1 March 2002 STS-109, Columbia | 1 March 2002 STS-109, Columbia | 12 March 2002 STS-109, Columbia | 12 March 2002 STS-109, Columbia | Hubble Space Telescope servicing mission. |
| 233 | Michael J. Bloomfield (3) Stephen N. Frick (1) Jerry L. Ross (7) Steven L. Smith (4) Ellen L. Ochoa (4) Lee Morin (1) Rex J. Walheim (1) | 8 April 2002 STS-110, Atlantis | ISS | ISS | 19 April 2002 STS-110, Atlantis | ISS assembly and supply. |
| 234 | Yuri Gidzenko (3) Roberto Vittori (1) Mark Shuttleworth | 25 April 2002 Soyuz TM-34 | ISS | ISS | 5 May 2002 Soyuz TM-33 | First South African in space (Shuttleworth). Second space tourist (Shuttleworth). |
| 235 | Kenneth D. Cockrell (5) Paul S. Lockhart (1) Franklin R. Chang-Diaz (7) Philippe Perrin | 5 June 2002 STS-111, Endeavour | ISS | ISS | 19 June 2002 STS-111, Endeavour | ISS crew rotation, assembly and supply. |
| 235 | Valeri Korzun (2) Sergei Treshchev Peggy A. Whitson (1) | 5 June 2002 STS-111, Endeavour | ISS (crew 5) | ISS (crew 5) | 7 December 2002 STS-113, Endeavour | ISS crew rotation, assembly and supply. |
| 236 | Jeffrey S. Ashby (3) Pamela A. Melroy (2) David A. Wolf (3) Piers J. Sellers (1) Sandra H. Magnus (1) Fyodor Yurchikhin (1) | 7 October 2002 STS-112, Atlantis | ISS | ISS | 18 October 2002 STS-112, Atlantis | ISS assembly, maintenance and supply. |
| 237 | Sergei Zalyotin (2) Yuri Lonchakov (2) Frank De Winne (1) | 29 October 2002 Soyuz TMA-1 | ISS | ISS | 10 November 2002 Soyuz TM-34 | |
| 238 | James D. Wetherbee (6) Paul S. Lockhart (2) Michael E. Lopez-Alegria (3) John B. Herrington | 23 November 2002 STS-113, Endeavour | ISS | ISS | 7 December 2002 STS-113, Endeavour | ISS assembly, crew rotation and supply. |
| 238 | Kenneth D. Bowersox (5) Donald R. Pettit (1) Nikolai Budarin (3) | 23 November 2002 STS-113, Endeavour | ISS (crew 6) | ISS (crew 6) | 4 May 2003 Soyuz TMA-1 | ISS assembly, crew rotation and supply. |
| 239 | Rick D. Husband (2) William C. McCool David M. Brown Kalpana Chawla (2) Michael P. Anderson (2) Laurel B. Clark Ilan Ramon | 16 January 2003 STS-107, Columbia | 16 January 2003 STS-107, Columbia | 1 February 2003 STS-107, Columbia | 1 February 2003 STS-107, Columbia | Microgravity and Earth science research. First Israeli in space (Ramon). Broke up during re-entry with loss of all crew. |
| 240 | Yuri Malenchenko (3) Edward T. Lu (3) | 25 April 2003 Soyuz TMA-2 | ISS (crew 7) | ISS (crew 7) | 27 October 2003 Soyuz TMA-2 | ISS crew rotation. |
| 241 | Yang Liwei | 15 October 2003 Shenzhou 5 | 15 October 2003 Shenzhou 5 | 15 October 2003 Shenzhou 5 | 15 October 2003 Shenzhou 5 | First human spaceflight of the People's Republic of China. |
| 242 | Pedro Duque (2) | 18 October 2003 Soyuz TMA-3 | ISS | ISS | 27 October 2003 Soyuz TMA-2 | ISS crew rotation. |
| 242 | Aleksandr Kaleri (4) C. Michael Foale (6) | 18 October 2003 Soyuz TMA-3 | ISS (crew 8) | ISS (crew 8) | 29 April 2004 Soyuz TMA-3 | ISS crew rotation. |
| 243 | André Kuipers (1) | 19 April 2004 Soyuz TMA-4 | ISS | ISS | 29 April 2004 Soyuz TMA-3 | ISS crew rotation. |
| 243 | Gennady Padalka (2) E. Michael Fincke (1) | 19 April 2004 Soyuz TMA-4 | ISS (crew 9) | ISS (crew 9) | 24 October 2004 Soyuz TMA-4 | ISS crew rotation. |
| 244 | Michael W. Melvill (1) | 21 June 2004 Flight 15P, SpaceShipOne | 21 June 2004 Flight 15P, SpaceShipOne | 21 June 2004 Flight 15P, SpaceShipOne | 21 June 2004 Flight 15P, SpaceShipOne | First human spaceflight of commercial spaceship. |
| 245 | Michael W. Melvill (2) | 29 September 2004 Flight 16P, SpaceShipOne | 29 September 2004 Flight 16P, SpaceShipOne | 29 September 2004 Flight 16P, SpaceShipOne | 29 September 2004 Flight 16P, SpaceShipOne | Ansari X Prize flight #1. |
| 246 | W. Brian Binnie | 4 October 2004 Flight 17P, SpaceShipOne | 4 October 2004 Flight 17P, SpaceShipOne | 4 October 2004 Flight 17P, SpaceShipOne | 4 October 2004 Flight 17P, SpaceShipOne | Ansari X Prize flight #2, winning the prize. |
| 247 | Yuri Shargin | 14 October 2004 Soyuz TMA-5 | ISS | ISS | 24 October 2004 Soyuz TMA-4 | ISS crew rotation. |
| 247 | Salizhan Sharipov (2) Leroy Chiao (4) | 14 October 2004 Soyuz TMA-5 | ISS (crew 10) | ISS (crew 10) | 24 April 2005 Soyuz TMA-5 | ISS crew rotation. |
| 248 | Roberto Vittori (2) | 15 April 2005 Soyuz TMA-6 | ISS | ISS | 24 April 2005 Soyuz TMA-5 | ISS crew rotation. |
| 248 | Sergei Krikalev (6) John L. Phillips (2) | 15 April 2005 Soyuz TMA-6 | ISS (crew 11) | ISS (crew 11) | 11 October 2005 Soyuz TMA-6 | ISS crew rotation. |
| 249 | Eileen M. Collins (4) James M. Kelly (2) Stephen K. Robinson (3) Andrew S. W. Thomas (4) Wendy B. Lawrence (4) Charles J. Camarda Soichi Noguchi (1) | 26 July 2005 STS-114, Discovery | ISS | ISS | 9 August 2005 STS-114, Discovery | First "Return to Flight" Space Shuttle mission after the loss of Columbia. ISS assembly and supply. |
| 250 | Gregory H. Olsen | 1 October 2005 Soyuz TMA-7 | ISS | ISS | 11 October 2005 Soyuz TMA-6 | ISS crew rotation. Third space tourist (Olsen). |
| 250 | Valery Tokarev (2) William S. McArthur (4) | 1 October 2005 Soyuz TMA-7 | ISS (crew 12) | ISS (crew 12) | 8 April 2006 Soyuz TMA-7 | ISS crew rotation. Third space tourist (Olsen). |
| 251 | Fèi Jùnlóng (1) Niè Hǎishèng (1) | 12 October 2005 Shenzhou 6 | 12 October 2005 Shenzhou 6 | 16 October 2005 Shenzhou 6 | 16 October 2005 Shenzhou 6 | Second human spaceflight of the People's Republic of China. |
| 252 | Marcos Pontes | 30 March 2006 Soyuz TMA-8 | ISS (MC) | ISS (MC) | 8 April 2006 Soyuz TMA-7 | ISS crew rotation. First Brazilian in space (Pontes). |
| 252 | Pavel Vinogradov (2) Jeffrey N. Williams (2) | 30 March 2006 Soyuz TMA-8 | ISS (crew 13) | ISS (crew 13) | 29 September 2006 Soyuz TMA-8 | ISS crew rotation. First Brazilian in space (Pontes). |
| 253 | Steven W. Lindsey (4) Mark Kelly (2) Michael E. Fossum (1) Piers J. Sellers (2) Lisa M. Nowak Stephanie D. Wilson (1) | 4 July 2006 STS-121, Discovery | ISS | ISS | 17 July 2006 STS-121, Discovery | ISS crew rotation and supply. Safety and repair system testing. First long-duration ISS mission by an ESA astronaut (Reiter). |
| 253 | Thomas Reiter (2) | 4 July 2006 STS-121, Discovery | ISS (crew 13/14) | ISS (crew 13/14) | 22 December 2006 STS-116, Discovery | ISS crew rotation and supply. Safety and repair system testing. First long-duration ISS mission by an ESA astronaut (Reiter). |
| 254 | Brent W. Jett (4) Christopher J. Ferguson (1) Joseph R. Tanner (4) Daniel C. Burbank (2) Heidemarie M. Stefanyshyn-Piper (1) Steven G. MacLean (2) | 9 September 2006 STS-115, Atlantis | ISS | ISS | 21 September 2006 STS-115, Atlantis | Resumption of ISS assembly. First Canadian to operate Canadarm2. Delivery of the second set of solar arrays and batteries. |
| 255 | Anousheh Ansari | 18 September 2006 Soyuz TMA-9 | ISS | ISS | 29 September 2006 Soyuz TMA-8 | ISS crew rotation. First female space tourist (Ansari). First Persian in space (Ansari). |
| 255 | Mikhail Tyurin (2) Michael E. Lopez-Alegria (4) | 18 September 2006 Soyuz TMA-9 | ISS (crew 14) | ISS (crew 14) | 21 April 2007 Soyuz TMA-9 | ISS crew rotation. First female space tourist (Ansari). First Persian in space (Ansari). |
| 256 | Mark L. Polansky (2) William A. Oefelein Robert L. Curbeam (3) Joan E. Higginbotham Nicholas J.M. Patrick (1) Christer Fuglesang (1) | 10 December 2006 STS-116, Discovery | ISS | ISS | 22 December 2006 STS-116, Discovery | ISS crew rotation and assembly First Swede in space (Fuglesang) |
| 256 | Sunita L. Williams (1) | 10 December 2006 STS-116, Discovery | ISS (crew 14/15) | ISS (crew 14/15) | 22 June 2007 STS-117, Atlantis | ISS crew rotation and assembly First Swede in space (Fuglesang) |
| 257 | Charles Simonyi (1) | 7 April 2007 Soyuz TMA-10 | ISS | ISS | 21 April 2007 Soyuz TMA-9 | ISS crew rotation. Space tourist flight. (Fifth space tourist and the second Hungarian, Simonyi, in space) |
| 257 | Oleg Kotov (1) Fyodor Yurchikhin (2) | 7 April 2007 Soyuz TMA-10 | ISS (crew 15) | ISS (crew 15) | 21 October 2007 Soyuz TMA-10 | ISS crew rotation. Space tourist flight. (Fifth space tourist and the second Hungarian, Simonyi, in space) |
| 258 | Frederick W. Sturckow (3) Lee J. Archambault (1) Patrick G. Forrester (2) Steven R. Swanson (1) John D. Olivas (1) James F. Reilly (3) | 8 June 2007 STS-117, Atlantis | ISS | ISS | 22 June 2007 STS-117, Atlantis | ISS crew rotation and assembly |
| 258 | Clayton C. Anderson (1) | 8 June 2007 STS-117, Atlantis | ISS (crew 15/16) | ISS (crew 15/16) | 7 November 2007 STS-120, Discovery | ISS crew rotation and assembly |
| 259 | Scott Kelly (2) Charles O. Hobaugh (2) Tracy E. Caldwell Dyson (1) Richard A. Mastracchio (2) Barbara R. Morgan Benjamin A. Drew (1) Dafydd R. Williams (2) | 8 August 2007 STS-118, Endeavour | ISS | ISS | 21 August 2007 STS-118, Endeavour | ISS assembly |
| 260 | Sheikh Muszaphar Shukor | 10 October 2007 Soyuz TMA-11 | ISS | ISS | 21 October 2007 Soyuz TMA-10 | ISS crew rotation. First Malaysian in space (Shukor). First female ISS commander (Whitson). |
| 260 | Yuri Malenchenko (4) Peggy A. Whitson (2) | 10 October 2007 Soyuz TMA-11 | ISS (crew 16) | ISS (crew 16) | 19 April 2008 Soyuz TMA-11 | ISS crew rotation. First Malaysian in space (Shukor). First female ISS commander (Whitson). |
| 261 | Pamela A. Melroy (3) George D. Zamka (1) Scott E. Parazynski (5) Stephanie D. Wilson (2) Douglas H. Wheelock (1) Paolo Nespoli (1) | 23 October 2007 STS-120, Discovery | ISS | ISS | 7 November 2007 STS-120, Discovery | ISS crew rotation and assembly |
| 261 | Daniel M. Tani (2) | 23 October 2007 STS-120, Discovery | ISS (crew 16) | ISS (crew 16) | 20 February 2008 STS-122, Atlantis | ISS crew rotation and assembly |
| 262 | Stephen N. Frick (2) Alan G. Poindexter (1) Leland D. Melvin (1) Rex J. Walheim (2) Stanley G. Love Hans Schlegel (2) | 7 February 2008 STS-122, Atlantis | ISS | ISS | 20 February 2008 STS-122, Atlantis | ISS crew rotation and assembly |
| 262 | Léopold Eyharts (2) | 7 February 2008 STS-122, Atlantis | ISS (crew 16) | ISS (crew 16) | 27 March 2008 STS-123, Endeavour | ISS crew rotation and assembly |
| 263 | Dominic L. Pudwill Gorie (4) Gregory H. Johnson (1) Robert L. Behnken (1) Michael J. Foreman (1) Richard M. Linnehan (4) Takao Doi (2) | 11 March 2008 STS-123, Endeavour | ISS | ISS | 27 March 2008 STS-123, Endeavour | ISS crew rotation and assembly |
| 263 | Garrett E. Reisman (1) | 11 March 2008 STS-123, Endeavour | ISS (crew 16/17) | ISS (crew 16/17) | 14 June 2008 STS-124, Discovery | ISS crew rotation and assembly |
| 264 | Yi So-yeon | 8 April 2008 Soyuz TMA-12 | ISS | ISS | 19 April 2008 Soyuz TMA-11 | ISS crew rotation. First South Korean in space (Yi) First second-generation cosmonaut (Volkov). |
| 264 | Sergey Volkov (1) Oleg Kononenko (1) | 8 April 2008 Soyuz TMA-12 | ISS (crew 17) | ISS (crew 17) | 24 October 2008 Soyuz TMA-12 | ISS crew rotation. First South Korean in space (Yi) First second-generation cosmonaut (Volkov). |
| 265 | Mark Kelly (3) Kenneth T. Ham (1) Karen L. Nyberg (1) Ronald J. Garan (1) Michael E. Fossum (2) Akihiko Hoshide (1) | 31 May 2008 STS-124, Discovery | ISS | ISS | 14 June 2008 STS-124, Discovery | ISS assembly and crew rotation Delivery of Kibo Japanese Experiment Module |
| 265 | Gregory E. Chamitoff (1) | 31 May 2008 STS-124, Discovery | ISS (crew 17/18) | ISS (crew 17/18) | 30 November 2008 STS-126, Endeavour | ISS assembly and crew rotation Delivery of Kibo Japanese Experiment Module |
| 266 | Zhai Zhigang (1) Liu Boming (1) Jing Haipeng (1) | 25 September 2008 Shenzhou 7 | 25 September 2008 Shenzhou 7 | 28 September 2008 Shenzhou 7 | 28 September 2008 Shenzhou 7 | Third human spaceflight and first spacewalk for China. |
| 267 | Richard A. Garriot | 12 October 2008 Soyuz TMA-13 | ISS | ISS | 24 October 2008 Soyuz TMA-12 | ISS crew rotation. |
| 267 | Yuri Lonchakov (3) E. Michael Fincke (2) | 12 October 2008 Soyuz TMA-13 | ISS (crew 18) | ISS (crew 18) | 8 April 2009 Soyuz TMA-13 | ISS crew rotation. |
| 268 | Christopher J. Ferguson (2) Eric A. Boe (1) Donald R. Pettit (2) Stephen G. Bowen (1) Heidemarie M. Stefanyshyn-Piper (2) Robert S. Kimbrough (1) | 15 November 2008 STS-126, Endeavour | ISS | ISS | 30 November 2008 STS-126, Endeavour | ISS logistics and crew rotation |
| 268 | Sandra H. Magnus (2) | 15 November 2008 STS-126, Endeavour | ISS (crew 18) | ISS (crew 18) | 29 March 2009 STS-119, Discovery | ISS logistics and crew rotation |
| 269 | Lee J. Archambault (2) Dominic A. Antonelli (1) Joseph M. Acaba (1) Steven R. Swanson (2) Richard R. Arnold (1) John L. Phillips (3) | 15 March 2009 STS-119, Discovery | ISS | ISS | 29 March 2009 STS-119, Discovery | Delivery of final solar power generation module and crew rotation |
| 269 | Koichi Wakata (3) | 15 March 2009 STS-119, Discovery | ISS (crew 18/19/20) | ISS (crew 18/19/20) | 31 July 2009 STS-127, Endeavour | Delivery of final solar power generation module and crew rotation |
| 270 | Charles Simonyi (2) | 26 March 2009 Soyuz TMA-14 | ISS | ISS | 8 April 2009 Soyuz TMA-13 | ISS crew rotation. |
| 270 | Gennady Padalka (3) Michael R. Barratt (1) | 26 March 2009 Soyuz TMA-14 | ISS (crew 19/20) | ISS (crew 19/20) | 11 October 2009 Soyuz TMA-14 | ISS crew rotation. |
| 271 | Scott D. Altman (4) Gregory C. Johnson Michael T. Good (1) K. Megan McArthur (1) John M. Grunsfeld (5) Michael J. Massimino (2) Andrew J. Feustel (1) | 11 May 2009 STS-125, Atlantis | 11 May 2009 STS-125, Atlantis | 24 May 2009 STS-125, Atlantis | 24 May 2009 STS-125, Atlantis | Hubble Space Telescope Servicing Mission 4 |
| 272 | Roman Romanenko (1) Frank De Winne (2) Robert Thirsk (2) | 27 May 2009 Soyuz TMA-15 | ISS (crew 20/21) | ISS (crew 20/21) | 1 December 2009 Soyuz TMA-15 | ISS crew rotation. |
| 273 | Mark L. Polansky (3) Douglas G. Hurley (1) Christopher J. Cassidy (1) Thomas H. Marshburn (1) David A. Wolf (4) Julie Payette (2) | 15 July 2009 STS-127, Endeavour | ISS | ISS | 31 July 2009 STS-127, Endeavour | Delivery of Japanese exposed facility and crew rotation |
| 273 | Timothy L. Kopra (1) | 15 July 2009 STS-127, Endeavour | ISS (crew 20) | ISS (crew 20) | 11 September 2009 STS-128, Discovery | Delivery of Japanese exposed facility and crew rotation |
| 274 | Frederick W. Sturckow (4) Kevin A. Ford (1) Patrick G. Forrester (3) José M. Hernández John D. Olivas (2) Christer Fuglesang (2) | 28 August 2009 STS-128, Discovery | ISS | ISS | 11 September 2009 STS-128, Discovery | Delivery of experiments, logistics, and crew rotation |
| 274 | Nicole P. Stott (1) | 28 August 2009 STS-128, Discovery | ISS (crew 20/21) | ISS (crew 20/21) | 27 November 2009 STS-129, Atlantis | Delivery of experiments, logistics, and crew rotation |
| 275 | Guy Laliberté | 30 September 2009 Soyuz TMA-16 | ISS | ISS | 11 October 2009 Soyuz TMA-14 | First Canadian space tourist, ISS crew rotation. |
| 275 | Maksim Surayev (1) Jeffrey N. Williams (3) | 30 September 2009 Soyuz TMA-16 | ISS (crew 21/22) | ISS (crew 21/22) | 18 March 2010 Soyuz TMA-16 | First Canadian space tourist, ISS crew rotation. |
| 276 | Charles O. Hobaugh (3) Barry E. Wilmore (1) Leland D. Melvin (2) Randolph J. Bresnik (1) Michael J. Foreman (2) Robert L. Satcher | 16 November 2009 STS-129, Atlantis | ISS | ISS | 27 November 2009 STS-129, Atlantis | ISS assembly Delivery of ELC1 and ELC2 |
| 277 | Oleg Kotov (2) Timothy J. Creamer Soichi Noguchi (2) | 20 December 2009 Soyuz TMA-17 | ISS (crew 22/23) | ISS (crew 22/23) | 2 June 2010 Soyuz TMA-17 | ISS crew rotation. |
| 278 | George D. Zamka (2) Terry W. Virts (1) Kathryn P. Hire (2) Stephen K. Robinson (4) Nicolas J.M. Patrick (2) Robert L. Behnken (2) | 8 February 2010 STS-130, Endeavour | ISS | ISS | 22 February 2010 STS-130, Endeavour | ISS assembly Delivery of Tranquility and Cupola |
| 279 | Aleksandr Skvortsov (1) Mikhail Korniyenko (1) Tracy E. Caldwell Dyson (2) | 2 April 2010 Soyuz TMA-18 | ISS (crew 23/24) | ISS (crew 23/24) | 25 September 2010 Soyuz TMA-18 | ISS crew rotation. |
| 280 | Alan G. Poindexter (2) James P. Dutton Richard A. Mastracchio (3) Clayton C. Anderson (2) Dorothy M. Metcalf-Lindenburger Stephanie D. Wilson (3) Naoko Yamazaki | 5 April 2010 STS-131, Discovery | ISS | ISS | 20 April 2010 STS-131, Discovery | ISS assembly Delivery of experiments and logistics |
| 281 | Kenneth T. Ham (2) Dominic A. Antonelli (2) Garrett E. Reisman (2) Michael T. Good (2) Stephen G. Bowen (2) Piers J. Sellers (3) | 14 May 2010 STS-132, Atlantis | ISS | ISS | 26 May 2010 STS-132, Atlantis | Delivery of experiments Delivery of Rassvet |
| 282 | Fyodor Yurchikhin (3) Shannon Walker (1) Douglas H. Wheelock (2) | 15 June 2010 Soyuz TMA-19 | ISS (crew 24/25) | ISS (crew 24/25) | 26 November 2010 Soyuz TMA-19 | ISS crew rotation. |
| 283 | Aleksandr Kaleri (5) Oleg Skripochka (1) Scott Kelly (3) | 7 October 2010 Soyuz TMA-01M | ISS (crew 25/26) | ISS (crew 25/26) | 16 March 2011 Soyuz TMA-01M | ISS crew rotation. |
| 284 | Dmitri Kondratyev Catherine G. Coleman (3) Paolo Nespoli (2) | 15 December 2010 Soyuz TMA-20 | ISS (crew 26/27) | ISS (crew 26/27) | 24 May 2011 Soyuz TMA-20 | ISS crew rotation. |