# 2022 Istanbul Challenger – Singles

James Duckworth was the defending champion but lost in the first round to Lukáš Rosol.
Radu Albot won the title after defeating Rosol 6–2, 6–0 in the final.

## Seeds

* James Duckworth (first round)
* Radu Albot (champion)
* Fernando Verdasco (second round)
* Geoffrey Blancaneaux (semifinals)
* Paul Jubb (first round)
* Laurent Lokoli (quarterfinals)
* Sebastian Ofner (quarterfinals)
* Nicolás Álvarez Varona (second round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| | Lukáš Rosol | 6 | 6 | | | | | |
| WC | Koray Kırcı | 3 | 4 | | | | | |
| WC | Koray Kırcı | 3 | 4 | | | Lukáš Rosol | 2 | 0 |
| | | | | | 2 | Radu Albot | 6 | 6 |
| 4 | Geoffrey Blancaneaux | 6 | 1 | 2 | 2 | Radu Albot | 6 | 6 |
| 2 | Radu Albot | 1 | 6 | 6 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | J Duckworth | 2 | 6$^1$ | | | | | | | | | | | | | | | |
| | L Rosol | 6 | 7$^7$ | | | L Rosol | 6 | 6 | | | | | | | | | | |
| | B Lock | 3 | 2 | | | R Haase | 3 | 1 | | | | | | | | | | |
| | R Haase | 6 | 6 | | | | | | | | L Rosol | 6 | 6 | | | | | |
| Q | T Atmane | 6 | 6 | | | | | | | 6 | L Lokoli | 4 | 4 | | | | | |
| | B Patael | 4 | 4 | | Q | T Atmane | 6$^5$ | 7 | 4 | | | | | | | | | |
| | E Donskoy | 3 | 2 | | 6 | L Lokoli | 7$^7$ | 5 | 6 | | | | | | | | | |
| 6 | L Lokoli | 6 | 6 | | | | | | | | | | | | | L Rosol | 6 | 6 |
| 3 | F Verdasco | 6 | 6 | | | | | | | | | | | | WC | K Kırcı | 3 | 4 |
| WC | Berk İlkel | 4 | 1 | | 3 | F Verdasco | 4 | 3 | | | | | | | | | | |
| WC | A Metreveli | 7$^{11}$ | 4 | 2 | WC | K Kırcı | 6 | 6 | | | | | | | | | | |
| WC | K Kırcı | 6$^9$ | 6 | 6 | | | | | | WC | K Kırcı | 4 | 6 | 6 | | | | |
| Q | M Gengel | 5 | 4 | | | | | | | 7 | S Ofner | 6 | 3 | 3 | | | | |
| | I Marchenko | 7 | 6 | | | I Marchenko | 1 | 5 | | | | | | | | | | |
| Q | S Ağabigün | 2 | 4 | | 7 | S Ofner | 6 | 7 | | | | | | | | | | |
| 7 | S Ofner | 6 | 6 | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 5 | P Jubb | 3 | 7 | 0 | | | | | | | | | | | | | | | |
| | H Mayot | 6 | 5 | 6 | | H Mayot | 7 | 7 | | | | | | | | | | | |
| | L Giustino | 6 | 6 | | | L Giustino | 5 | 5 | | | | | | | | | | | |
| Q | Dominik Palán | 2 | 2 | | | | | | | | H Mayot | 3 | 4 | | | | | | |
| | H Međedović | 4 | 4 | | | | | | | 4 | G Blancaneaux | 6 | 6 | | | | | | |
| | A Gray | 6 | 6 | | | A Gray | 7$^7$ | 2 | 2 | | | | | | | | | | |
| | A Kachmazov | 4 | 4 | | 4 | G Blancaneaux | 6$^4$ | 6 | 6 | | | | | | | | | | |
| 4 | G Blancaneaux | 6 | 6 | | | | | | | | | | | | 4 | G Blancaneaux | 6 | 1 | 2 |
| 8 | N Álvarez Varona | 6 | 6 | | | | | | | | | | | | 2 | R Albot | 1 | 6 | 6 |
| | A Šetkić | 1 | 4 | | 8 | N Álvarez Varona | 4 | 1 | | | | | | | | | | | |
| Q | B Zhukayev | 6 | 6 | | Q | B Zhukayev | 6 | 6 | | | | | | | | | | | |
| Q | Cengiz Aksu | 3 | 4 | | | | | | | Q | B Zhukayev | 2 | 6 | 6$^4$ | | | | | |
| | H Squire | 6 | 0 | | | | | | | 2 | R Albot | 6 | 4 | 7$^7$ | | | | | |
| LL | Bogdan Ionuț Apostol | 2 | 0$^r$ | | | H Squire | 4 | 3 | | | | | | | | | | | |
| | FC Jianu | 6$^6$ | 4 | | 2 | R Albot | 6 | 6 | | | | | | | | | | | |
| 2 | R Albot | 7$^8$ | 6 | | | | | | | | | | | | | | | | |