# 2021 Internationaux de Tennis de Vendée – Singles

Mikael Ymer was the defending champion but chose not to defend his title.
Jiří Veselý won the title after defeating Norbert Gombos 6–4, 6–4 in the final.

## Seeds

* Benjamin Bonzi (first round)
* Jiří Veselý (champion)
* Peter Gojowczyk (first round)
* Andreas Seppi (semifinals)
* Gilles Simon (first round, withdrew)
* Pierre-Hugues Herbert (quarterfinals)
* Ričardas Berankis (second round)
* Norbert Gombos (final)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| Q | Mats Rosenkranz | 4 | 6$^4$ | | | | |
| 8 | Norbert Gombos | 6 | 7$^7$ | | | | |
| 8 | Norbert Gombos | 6 | 7$^7$ | 8 | Norbert Gombos | 4 | 4 |
| | | | | 2 | Jiří Veselý | 6 | 6 |
| 4 | Andreas Seppi | 4 | 6$^1$ | 2 | Jiří Veselý | 6 | 6 |
| 2 | Jiří Veselý | 6 | 7$^7$ | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | B Bonzi | 6$^4$ | 4 | | | | | | | | | | | | | | | |
| Q | M Rosenkranz | 7$^7$ | 6 | | Q | M Rosenkranz | 6 | 3 | | | | | | | | | | |
| | K Majchrzak | 7$^7$ | 3 | 6 | | K Majchrzak | 4 | 1$^r$ | | | | | | | | | | |
| Q | E Karlovskiy | 6$^5$ | 6 | 3 | | | | | | Q | M Rosenkranz | 6$^2$ | 6 | 7$^7$ | | | | |
| | R Bemelmans | 3 | 6 | 5 | | | | | | 6 | P-H Herbert | 7$^7$ | 3 | 6$^4$ | | | | |
| Alt | C Lestienne | 6 | 3 | 7 | Alt | C Lestienne | 6 | 6$^5$ | 4 | | | | | | | | | |
| WC | K Jacquet | 1 | 3 | | 6 | P-H Herbert | 3 | 7$^7$ | 6 | | | | | | | | | |
| 6 | P-H Herbert | 6 | 6 | | | | | | | | | | | | Q | M Rosenkranz | 4 | 6$^4$ |
| 3 | P Gojowczyk | 3 | 6 | 3 | | | | | | | | | | | 8 | N Gombos | 6 | 7$^7$ |
| | D Novak | 6 | 4 | 6 | | D Novak | 7$^7$ | 6 | | | | | | | | | | |
| | L Pouille | 2 | 6$^2$ | | | E Ymer | 6$^1$ | 4 | | | | | | | | | | |
| | E Ymer | 6 | 7$^7$ | | | | | | | | D Novak | 6 | 3 | 2 | | | | |
| | T Kamke | 2 | 6$^3$ | | | | | | | 8 | N Gombos | 4 | 6 | 6 | | | | |
| LL | K de Schepper | 6 | 7$^7$ | | LL | K de Schepper | 6$^1$ | 6$^4$ | | | | | | | | | | |
| | R Safiullin | 4 | 5 | | 8 | N Gombos | 7$^7$ | 7$^7$ | | | | | | | | | | |
| 8 | N Gombos | 6 | 7 | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 7 | R Berankis | 7$^7$ | 6 | | | | | | | | | | | | | | | |
| Q | T Droguet | 6$^0$ | 2 | | 7 | R Berankis | 6$^4$ | 5 | | | | | | | | | | |
| | Q Halys | 7 | 7$^7$ | | | Q Halys | 7$^7$ | 7 | | | | | | | | | | |
| | G Barrère | 5 | 6$^5$ | | | | | | | | Q Halys | 6 | 6$^6$ | 3 | | | | |
| | T Macháč | 6 | 6 | | | | | | | 4 | A Seppi | 2 | 7$^8$ | 6 | | | | |
| | B Gojo | 2 | 4 | | | T Macháč | 6$^3$ | 6 | 4 | | | | | | | | | |
| | F Verdasco | 5 | 1 | | 4 | A Seppi | 7$^7$ | 4 | 6 | | | | | | | | | |
| 4 | A Seppi | 7 | 6 | | | | | | | | | | | | 4 | A Seppi | 4 | 6$^1$ |
| 5 | G Simon | | | | | | | | | | | | | | 2 | J Veselý | 6 | 7$^7$ |
| | M Moraing | w/o | | | | M Moraing | 6 | 6$^2$ | 6 | | | | | | | | | |
| WC | A Fils | 6$^2$ | 3 | | Q | Z Bergs | 4 | 7$^7$ | 4 | | | | | | | | | |
| Q | Z Bergs | 7$^7$ | 6 | | | | | | | | M Moraing | 1$^r$ | | | | | | |
| | A Hoang | 6$^4$ | 3 | | | | | | | 2 | J Veselý | 4 | | | | | | |
| WC | H Mayot | 7$^7$ | 6 | | WC | H Mayot | 2 | 4 | | | | | | | | | | |
| | F Ferreira Silva | 6 | 3 | 2 | 2 | J Veselý | 6 | 6 | | | | | | | | | | |
| 2 | J Veselý | 3 | 6 | 6 | | | | | | | | | | | | | | |