# 2021 Internazionali di Tennis Città di Perugia – Singles

Federico Delbonis was the defending champion but chose not to defend his title.
Tomás Martín Etcheverry won the title after defeating Vitaliy Sachko 7–5, 6–2 in the final.

## Seeds

* Salvatore Caruso (semifinals)
* Andrej Martin (first round)
* Federico Gaio (first round)
* Zhang Zhizhen (second round)
* Thomas Fabbiano (first round)
* Dmitry Popko (first round)
* Tomás Martín Etcheverry (champion)
* Renzo Olivo (second round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| 1 | Salvatore Caruso | 5 | 7 | 2 | | | | |
| 7 | Tomás Martín Etcheverry | 7 | 5 | 6 | | | | |
| 7 | Tomás Martín Etcheverry | 7 | 5 | 6 | 7 | Tomás Martín Etcheverry | 7 | 6 |
| | | | | | | Vitaliy Sachko | 5 | 2 |
| | Nino Serdarušić | 4 | 5 | | | Vitaliy Sachko | 5 | 2 |
| | Vitaliy Sachko | 6 | 7 | | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | S Caruso | 7$^7$ | 6 | | | | | | | | | | | | | | | |
| WC | L Vanni | 6$^5$ | 4 | | 1 | S Caruso | 6 | 6 | | | | | | | | | | |
| | A Collarini | 6 | 5 | 1 | WC | F Forti | 4 | 4 | | | | | | | | | | |
| WC | F Forti | 4 | 7 | 6 | | | | | 1 | S Caruso | 6 | 3 | 6 | | | | | |
| | F Baldi | 3 | 3 | | | | | | WC | F Cobolli | 4 | 6 | 3 | | | | | |
| | N Borges | 6 | 5$^r$ | | | F Baldi | 2 | 6$^3$ | | | | | | | | | | |
| WC | F Cobolli | 2 | 7 | 7$^7$ | WC | F Cobolli | 6 | 7$^7$ | | | | | | | | | | |
| 6 | D Popko | 6 | 5 | 6$^3$ | | | | | | | | | | 1 | S Caruso | 5 | 7 | 2 |
| 3 | F Gaio | 6 | 3 | 6$^2$ | | | | | | | | | | 7 | TM Etcheverry | 7 | 5 | 6 |
| | D Kuzmanov | 2 | 6 | 7$^7$ | | D Kuzmanov | 4 | 6$^5$ | | | | | | | | | | |
| | P Cachin | 4 | 6$^5$ | | Q | N Fatić | 6 | 7$^7$ | | | | | | | | | | |
| Q | N Fatić | 6 | 7$^7$ | | | | | | Q | N Fatić | 3 | 1 | | | | | | |
| | Y Maden | 6$^3$ | 1 | | | | | | 7 | TM Etcheverry | 6 | 6 | | | | | | |
| | D Stricker | 7$^7$ | 6 | | | D Stricker | 5 | 4 | | | | | | | | | | |
| | A Arnaboldi | 6$^3$ | 2 | | 7 | TM Etcheverry | 7 | 6 | | | | | | | | | | |
| 7 | TM Etcheverry | 7$^7$ | 6 | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals |
| 8 | R Olivo | 6$^5$ | 7 | 6 | | | | | | | | | | | | | |
| Q | G Zeppieri | 7$^7$ | 5 | 2 | 8 | R Olivo | 5 | 5 | | | | | | | | | |
| Q | T Skatov | 1 | 7$^7$ | 6 | Q | T Skatov | 7 | 7 | | | | | | | | | |
| | L Giustino | 6 | 6$^5$ | 0 | | | | | | Q | T Skatov | 7$^8$ | 4 | 4 | | | |
| | N Serdarušić | 6 | 6 | | | | | | | | N Serdarušić | 6$^6$ | 6 | 6 | | | |
| | A Pellegrino | 3 | 3 | | | N Serdarušić | 7$^8$ | 6 | | | | | | | | | |
| Q | F Passaro | 6 | 3 | 2 | 4 | Zh Zhang | 6$^6$ | 4 | | | | | | | | | |
| 4 | Zh Zhang | 3 | 6 | 6 | | | | | | | | | | | N Serdarušić | 4 | 5 |
| 5 | T Fabbiano | 1 | 6 | 2 | | | | | | | | | | | V Sachko | 6 | 7 |
| | H Rune | 6 | 4 | 6 | | H Rune | 6 | 6 | | | | | | | | | |
| | L Klein | 6 | 7$^7$ | | | L Klein | 4 | 4 | | | | | | | | | |
| | R Bonadio | 1 | 6$^4$ | | | | | | | | H Rune | 3 | 6$^4$ | | | | |
| | GM Moroni | 2 | | | | | | | | | V Sachko | 6 | 7$^7$ | | | | |
| | E Furness | 0$^r$ | | | | GM Moroni | 5 | 6 | 4 | | | | | | | | |
| | V Sachko | 6 | 3 | 6 | | V Sachko | 7 | 4 | 6 | | | | | | | | |
| 2 | A Martin | 3 | 6 | 2 | | | | | | | | | | | | | |