# 2022 Uruguay Open – Singles

Hugo Dellien was the defending champion but chose not to defend his title.
Genaro Alberto Olivieri won the title after defeating Tomás Martín Etcheverry 6–7$^{(3–7)}$, 7–6$^{(7–5)}$, 6–3 in the final.

## Seeds

* Federico Coria (withdrew)
* Tomás Martín Etcheverry (final)
* Daniel Altmaier (semifinals)
* Facundo Bagnis (quarterfinals)
* Marco Cecchinato (first round)
* Camilo Ugo Carabelli (first round)
* Juan Manuel Cerúndolo (second round, retired)
* Franco Agamenone (semifinals)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final | Final |
| Alt | Genaro Alberto Olivieri | 2 | 6 | 6 | | | | | |
| 8 | Franco Agamenone | 6 | 4 | 4 | | | | | |
| 8 | Franco Agamenone | 6 | 4 | 4 | Alt | Genaro Alberto Olivieri | 6$^3$ | 7$^7$ | 6 |
| | | | | | 2 | Tomás Martín Etcheverry | 7$^7$ | 6$^5$ | 3 |
| 3 | Daniel Altmaier | 7$^7$ | 3 | 6$^6$ | 2 | Tomás Martín Etcheverry | 7$^7$ | 6$^5$ | 3 |
| 2 | Tomás Martín Etcheverry | 6$^5$ | 6 | 7$^8$ | | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| Q | E Ribeiro | 7 | 0 | 2 | | | | | | | | | | | | | | | |
| | G Elias | 5 | 6 | 6 | | G Elias | 5 | 3 | | | | | | | | | | | |
| Q | J Choinski | 5 | 5 | | Alt | GA Olivieri | 7 | 6 | | | | | | | | | | | |
| Alt | GA Olivieri | 7 | 7 | | | | | | | Alt | GA Olivieri | 6 | 6 | | | | | | |
| Q | M Houkes | 7 | 6 | | | | | | | | M Trungelliti | 1 | 4 | | | | | | |
| WC | F Roncadelli | 5 | 2 | | Q | M Houkes | 6$^6$ | 2 | | | | | | | | | | | |
| | M Trungelliti | 6 | 6 | | | M Trungelliti | 7$^8$ | 6 | | | | | | | | | | | |
| 5 | M Cecchinato | 4 | 4 | | | | | | | | | | | | Alt | GA Olivieri | 2 | 6 | 6 |
| 4 | F Bagnis | 7$^7$ | 6 | | | | | | | | | | | | 8 | F Agamenone | 6 | 4 | 4 |
| Q | F Zeballos | 6$^5$ | 3 | | 4 | F Bagnis | 6$^5$ | 6 | 6 | | | | | | | | | | |
| LL | G Villanueva | 4 | 6$^9$ | | Q | JP Paz | 7$^7$ | 1 | 0 | | | | | | | | | | |
| Q | JP Paz | 6 | 7$^{11}$ | | | | | | | 4 | F Bagnis | 6 | 1 | 2 | | | | | |
| | F Comesaña | 1 | 1 | | | | | | | 8 | F Agamenone | 3 | 6 | 6 | | | | | |
| Q | M Echargui | 6 | 6 | | Q | M Echargui | 5 | 3 | | | | | | | | | | | |
| | A Collarini | 4 | 5 | | 8 | F Agamenone | 7 | 6 | | | | | | | | | | | |
| 8 | F Agamenone | 6 | 7 | | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 6 | C Ugo Carabelli | 4 | 4 | | | | | | | | | | | | | | | |
| | N Kicker | 6 | 6 | | N Kicker | 4 | 6 | 6 | | | | | | | | | | |
| | M Pucinelli de Almeida | 7$^7$ | 6 | | M Pucinelli de Almeida | 6 | 3 | 3 | | | | | | | | | | |
| | S Rodríguez Taverna | 6$^5$ | 3 | | | | | | | N Kicker | 4 | 6 | 3 | | | | | |
| | F Meligeni Alves | 6 | 6 | | | | | | 3 | D Altmaier | 6 | 1 | 6 | | | | | |
| PR | S Nagal | 4 | 3 | | F Meligeni Alves | 6$^5$ | 3 | | | | | | | | | | | |
| | JB Torres | 2 | 2 | 3 | D Altmaier | 7$^7$ | 6 | | | | | | | | | | | |
| 3 | D Altmaier | 6 | 6 | | | | | | | | | | | 3 | D Altmaier | 7$^7$ | 3 | 6$^6$ |
| 7 | JM Cerúndolo | 7 | 6 | | | | | | | | | | | 2 | TM Etcheverry | 6$^5$ | 6 | 7$^8$ |
| WC | G Pella | 5 | 3 | 7 | JM Cerúndolo | 3 | 0$^r$ | | | | | | | | | | | |
| | H Casanova | 3 | 1$^r$ | | F Díaz Acosta | 6 | 3 | | | | | | | | | | | |
| | F Díaz Acosta | 6 | 4 | | | | | | | F Díaz Acosta | 5 | 4 | | | | | | |
| WC | L Borg | 5 | 1 | | | | | | 2 | TM Etcheverry | 7 | 6 | | | | | | |
| | M Navone | 7 | 6 | | M Navone | 4 | 1 | | | | | | | | | | | |
| Alt | N Milojević | 3 | 2 | 2 | TM Etcheverry | 6 | 6 | | | | | | | | | | | |
| 2 | TM Etcheverry | 6 | 6 | | | | | | | | | | | | | | | |