# 2021 FINA World Swimming Championships (25 m) – Women's 4 × 50 metre medley relay

The Women's 4 × 50 metre medley relay competition of the 2021 FINA World Swimming Championships (25 m) was held on 17 December 2021.

## Records

Prior to the competition, the existing world and championship records were as follows.
| World record | United States (USA) | 1:42.38 | Hangzhou, China | 12 December 2018 |
| Competition record | United States (USA) | 1:42.38 | Hangzhou, China | 12 December 2018 |
The following new records were set during this competition:
| Date | Event | Name | Nation | Time | Record |
| 17 December | Final | Louise Hansson (25.91) Sophie Hansson (29.07) Sarah Sjöström (23.96) Michelle Coleman (23.44) | Sweden | 1:42.38 | =WR, =CR |

## Results
### Heats

The heats were started at 09:30.
| Rank | Heat | Lane | Nation | Swimmers | Time | Notes |
| 1 | 1 | 1 | United States | Katharine Berkoff (25.88) Emily Escobedo (30.32) Claire Curzan (24.87) Kate Douglass (23.43) | 1:44.50 | Q |
| 2 | 2 | 7 | Canada | Kylie Masse (26.12) Sydney Pickrem (29.87) Katerine Savard (25.54) Maggie Mac Neil (23.64) | 1:45.17 | Q, NR |
| 3 | 2 | 5 | Italy | Silvia Scalia (26.92) Arianna Castiglioni (29.51) Elena Di Liddo (25.17) Silvia Di Pietro (23.88) | 1:45.48 | Q |
| 4 | 1 | 2 | China | Peng Xuwei (27.21) Tang Qianting (29.10) Yu Yiting (25.65) Cheng Yujie (23.61) | 1:45.57 | Q |
| 5 | 1 | 4 | Sweden | Hanna Rosvall (26.82) Emelie Fast (29.71) Louise Hansson (25.28) Michelle Coleman (23.82) | 1:45.63 | Q |
| 6 | 2 | 4 | Russian Swimming Federation | Maria Kameneva (26.55) Evgeniia Chikunova (30.28) Arina Surkova (24.83) Rozaliya Nasretdinova (24.10) | 1:45.76 | Q |
| 7 | 1 | 5 | Netherlands | Tessa Giele (26.69) Kim Busch (30.64) Ranomi Kromowidjojo (24.67) Maaike de Waard (24.06) | 1:46.06 | Q |
| 8 | 2 | 1 | Belarus | Anastasiya Shkurdai (26.55) Alina Zmushka (30.04) Anastasiya Kuliashova (25.62) Nastassia Karakouskaya (24.47) | 1:46.68 | Q |
| 9 | 2 | 3 | France | Marie-Ambre Moluh (27.44) Justine Delmas (30.95) Béryl Gastaldello (25.38) Analia Pigrée (24.72) | 1:48.49 | |
| 10 | 1 | 6 | Switzerland | Nina Kost (27.89) Lisa Mamié (30.74) Alexandra Touretski (26.19) Maria Ugolkova (24.29) | 1:49.11 | NR |
| 11 | 1 | 7 | Hong Kong | Stephanie Au (27.47) Lam Hoi Kiu (31.34) Chan Kin Lok (26.56) Sze Hang-yu (24.75) | 1:50.12 | |
| 12 | 2 | 6 | Slovakia | Tamara Potocká (28.15) Andrea Podmaníková (30.33) Zora Ripková (26.53) Lillian Slušná (25.32) | 1:50.33 | |
| 13 | 2 | 2 | Thailand | Jinjutha Pholjamjumrus (29.19) Phiangkhwan Pawapotako (32.45) Jenjira Srisaard (26.01) Kornkarnjana Sapianchai (26.31) | 1:53.96 | |
| | 1 | 3 | Turkey | | DNS | |

### Final

The final was held at 18:00.
| Rank | Lane | Nation | Swimmers | Time | Notes |
| | 2 | Sweden | Louise Hansson (25.91 NR) Sophie Hansson (29.07) Sarah Sjöström (23.96) Michelle Coleman (23.44) | 1:42.38 | =WR |
| | 4 | United States | Rhyan White (26.33) Lydia Jacoby (29.62) Claire Curzan (24.56) Abbey Weitzeil (23.10) | 1:43.61 | |
| | 1 | Netherlands | Kira Toussaint (26.08) Kim Busch (30.59) Maaike de Waard (24.51) Ranomi Kromowidjojo (22.85) | 1:44.03 | |
| 4 | 5 | Canada | Kylie Masse (25.92) Sydney Pickrem (29.89) Maggie Mac Neil (24.85) Kayla Sanchez (23.50) | 1:44.16 | NR |
| 5 | 6 | China | Wan Letian (26.41) Tang Qianting (28.96) Yu Yiting (25.28) Cheng Yujie (23.78) | 1:44.43 | |
| 6 | 7 | Russian Swimming Federation | Maria Kameneva (26.32) Nika Godun (29.56) Arina Surkova (24.63) Rozaliya Nasretdinova (24.00) | 1:44.51 | |
| 7 | 3 | Italy | Elena Di Liddo (26.81) Arianna Castiglioni (29.34) Silvia Di Pietro (24.93) Costanza Cocconcelli (24.12) | 1:45.20 | |
| 8 | 8 | Belarus | Anastasiya Shkurdai (26.54) Alina Zmushka (29.72) Anastasiya Kuliashova (25.86) Nastassia Karakouskaya (24.27) | 1:46.39 | |