# 2022 San Marino Open – Singles

Holger Rune was the defending champion but chose not to defend his title.
Pavel Kotov won the title after defeating Matteo Arnaldi 7–6$^{(7–5)}$, 6–4 in the final.

## Seeds

* Carlos Taberner (second round)
* Pavel Kotov (champion)
* Giulio Zeppieri (first round)
* Flavio Cobolli (first round)
* Marco Cecchinato (semifinals)
* Alexandre Müller (first round)
* Nino Serdarušić (first round)
* Matteo Arnaldi (final)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| Alt | Filip Cristian Jianu | 1 | 5 | | | | | |
| 8 | Matteo Arnaldi | 6 | 7 | | | | | |
| 8 | Matteo Arnaldi | 6 | 7 | | 8 | Matteo Arnaldi | 6$^5$ | 4 |
| | | | | | 2 | Pavel Kotov | 7$^7$ | 6 |
| 5 | Marco Cecchinato | 6 | 5 | 1 | 2 | Pavel Kotov | 7$^7$ | 6 |
| 2 | Pavel Kotov | 3 | 7 | 6 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | C Taberner | 6 | 2 | 6 | | | | | | | | | | | | | |
| | O Roca Batalla | 4 | 6 | 2 | 1 | C Taberner | 4 | 3 | | | | | | | | | |
| Alt | FC Jianu | 7$^7$ | 6 | | Alt | FC Jianu | 6 | 6 | | | | | | | | | |
| WC | E Gulbis | 6$^4$ | 0 | | | | | | | Alt | FC Jianu | 6 | 6 | | | | |
| | R Haase | 7$^7$ | 6 | | | | | | | | N Sánchez Izquierdo | 2 | 4 | | | | |
| | O Virtanen | 6$^3$ | 3 | | | R Haase | 6 | 1 | 3 | | | | | | | | |
| | N Sánchez Izquierdo | 3 | 6 | 6 | | N Sánchez Izquierdo | 2 | 6 | 6 | | | | | | | | |
| 6 | A Müller | 6 | 3 | 0 | | | | | | | | | | Alt | FC Jianu | 1 | 5 |
| 4/WC | F Cobolli | 6$^5$ | 4 | | | | | | | | | | | 8 | M Arnaldi | 6 | 7 |
| | F Marozsán | 7$^7$ | 6 | | | F Marozsán | 6 | 6 | | | | | | | | | |
| | J Sels | 2 | 3 | | | M Gigante | 2 | 2 | | | | | | | | | |
| | M Gigante | 6 | 6 | | | | | | | | F Marozsán | 4 | 2 | | | | |
| Alt | I Gakhov | 2 | 6$^4$ | | | | | | | 8 | M Arnaldi | 6 | 6 | | | | |
| Q | L Neumayer | 6 | 7$^7$ | | Q | L Neumayer | 3 | 4 | | | | | | | | | |
| | F Gaio | 2 | 0 | | 8 | M Arnaldi | 6 | 6 | | | | | | | | | |
| 8 | M Arnaldi | 6 | 6 | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 5 | M Cecchinato | 6 | 6 | | | | | | | | | | | | | | | |
| WC | M Bellucci | 2 | 1 | | 5 | M Cecchinato | 6$^3$ | 7$^8$ | 6 | | | | | | | | | |
| | N Fatić | 3 | 2 | | Q | F Forti | 7$^7$ | 6$^6$ | 2 | | | | | | | | | |
| Q | F Forti | 6 | 6 | | | | | | | 5 | M Cecchinato | 7$^7$ | 6 | | | | | |
| | J de Jong | 6 | 6 | | | | | | | Q | V Vacherot | 6$^3$ | 1 | | | | | |
| | M Trungelliti | 3 | 4 | | | J de Jong | 2 | 3 | | | | | | | | | | |
| Q | V Vacherot | 2 | 7$^7$ | 6 | Q | V Vacherot | 6 | 6 | | | | | | | | | | |
| 3 | G Zeppieri | 6 | 6$^2$ | 1 | | | | | | | | | | 5 | M Cecchinato | 6 | 5 | 1 |
| 7 | N Serdarušić | 6$^0$ | 6 | 3 | | | | | | | | | | 2 | P Kotov | 3 | 7 | 6 |
| | L Giustino | 7$^7$ | 4 | 6 | | L Giustino | 2 | 5 | | | | | | | | | | |
| | T Skatov | 3 | 1 | | Q | A Weis | 6 | 7 | | | | | | | | | | |
| Q | Alexander Weis | 6 | 6 | | | | | | | Q | A Weis | 5 | 0 | | | | | |
| Alt | M Janvier | 6 | 3 | 7 | | | | | | 2 | P Kotov | 7 | 6 | | | | | |
| Q | O Prihodko | 1 | 6 | 5 | Alt | M Janvier | 4 | 3 | | | | | | | | | | |
| Q | V Durasovic | 1 | 1 | | 2 | P Kotov | 6 | 6 | | | | | | | | | | |
| 2 | P Kotov | 6 | 6 | | | | | | | | | | | | | | | |