# 2022 São Léo Open – Singles

This was the third edition of the tournament as an ATP Challenger Tour event and the first edition since 2012.
Juan Pablo Varillas won the title after defeating Facundo Bagnis 7–6$^{(7–5)}$, 4–6, 6–4 in the final.

## Seeds

* Facundo Bagnis (final)
* Juan Pablo Varillas (champion)
* Franco Agamenone (first round, retired)
* Felipe Meligeni Alves (semifinals)
* Renzo Olivo (first round)
* Facundo Díaz Acosta (second round)
* Matheus Pucinelli de Almeida (first round)
* Gastão Elias (first round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final | Final |
| 1 | Facundo Bagnis | 6$^4$ | 6 | 6 | | | | | |
| 4 | Felipe Meligeni Alves | 7$^7$ | 3 | 2 | | | | | |
| 4 | Felipe Meligeni Alves | 7$^7$ | 3 | 2 | 1 | Facundo Bagnis | 6$^5$ | 6 | 4 |
| | | | | | 2 | Juan Pablo Varillas | 7$^7$ | 4 | 6 |
| Alt | Thiago Seyboth Wild | 4 | 2 | | 2 | Juan Pablo Varillas | 7$^7$ | 4 | 6 |
| 2 | Juan Pablo Varillas | 6 | 6 | | | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | F Bagnis | 6 | 6 | | | | | | | | | | | | | | | | |
| | P Boscardin Dias | 4 | 2 | | 1 | F Bagnis | 7$^7$ | 6 | | | | | | | | | | | |
| Q | L Borg | 1 | 2 | | WC | G Heide | 6$^4$ | 3 | | | | | | | | | | | |
| WC | G Heide | 6 | 6 | | | | | | | 1 | F Bagnis | 6 | 6 | | | | | | |
| WC | J Fonseca | 6 | 7$^7$ | | | | | | | WC | J Fonseca | 3 | 4 | | | | | | |
| | TA Tirante | 4 | 6$^2$ | | WC | J Fonseca | 6 | 1 | 7$^{11}$ | | | | | | | | | | |
| | M Navone | 6 | 6 | | | M Navone | 3 | 6 | 6$^9$ | | | | | | | | | | |
| 8 | G Elias | 4 | 4 | | | | | | | | | | | | 1 | F Bagnis | 6$^4$ | 6 | 6 |
| 4 | F Meligeni Alves | 3 | 7 | 6 | | | | | | | | | | | 4 | F Meligeni Alves | 7$^7$ | 3 | 2 |
| | JB Torres | 6 | 5 | 1 | 4 | F Meligeni Alves | 6 | 6 | | | | | | | | | | | |
| | GA Olivieri | 5 | 4 | | | N Álvarez | 3 | 2 | | | | | | | | | | | |
| | N Álvarez | 7 | 6 | | | | | | | 4 | F Meligeni Alves | 6 | 4 | 6 | | | | | |
| | F Comesaña | 2 | 2 | | | | | | | | RA Burruchaga | 1 | 6 | 3 | | | | | |
| | RA Burruchaga | 6 | 6 | | | RA Burruchaga | 1 | 6 | 6 | | | | | | | | | | |
| | G Villanueva | 3 | 3 | | 6 | F Díaz Acosta | 6 | 3 | 0 | | | | | | | | | | |
| 6 | F Díaz Acosta | 6 | 6 | | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 5 | R Olivo | 4 | 6 | 3 | | | | | | | | | | | | | | |
| Q | M Alves | 6 | 4 | 6 | Q | M Alves | 6$^7$ | 1 | | | | | | | | | | |
| Alt | JL Reis da Silva | 6 | 6 | | Alt | JL Reis da Silva | 7$^9$ | 6 | | | | | | | | | | |
| Q | JP Paz | 3 | 2 | | | | | | | Alt | JL Reis da Silva | 2 | 5 | | | | | |
| | N Hardt | 6 | 3 | 6 | | | | | | Alt | T Seyboth Wild | 6 | 7 | | | | | |
| Q | Wilson Leite | 4 | 6 | 2 | | N Hardt | 1 | 2 | | | | | | | | | | |
| Alt | T Seyboth Wild | 7$^8$ | 5 | | Alt | T Seyboth Wild | 6 | 6 | | | | | | | | | | |
| 3 | F Agamenone | 6$^6$ | 1$^r$ | | | | | | | | | | | | Alt | T Seyboth Wild | 4 | 2 |
| 7/WC | M Pucinelli de Almeida | 5 | 2 | | | | | | | | | | | | 2 | JP Varillas | 6 | 6 |
| | D Dutra da Silva | 7 | 6 | | | D Dutra da Silva | 2 | 6 | 6 | | | | | | | | | |
| | J Domingues | 7$^7$ | 7 | | | J Domingues | 6 | 4 | 4 | | | | | | | | | |
| Q | M Houkes | 6$^0$ | 5 | | | | | | | | D Dutra da Silva | 6$^3$ | 7$^7$ | 6$^2$ | | | | |
| Q | D Wenger | 2 | 6$^5$ | | | | | | | 2 | JP Varillas | 7$^7$ | 6$^4$ | 7$^7$ | | | | |
| | G Lama | 6 | 7$^7$ | | | G Lama | 6$^2$ | 3 | | | | | | | | | | |
| LL | E Ribeiro | 1 | 6 | 3 | 2 | JP Varillas | 7$^7$ | 6 | | | | | | | | | | |
| 2 | JP Varillas | 6 | 4 | 6 | | | | | | | | | | | | | | |