# 2010 Knoxville Challenger – Singles

Taylor Dent was the defending champion, however he chose to not compete this year. Kei Nishikori won this tournament. He defeated Robert Kendrick 6–1, 6–4 in the final.

## Seeds

* Ryan Sweeting (first round)
* Donald Young (first round)
* Kei Nishikori (champion)
* Peter Luczak (first round)
* Marinko Matosevic (withdrew)
* Robert Kendrick (final)
* Carsten Ball (second round)
* Tim Smyczek (first round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| LL | Fritz Wolmarans | 4 | 4 | | | | |
| 6 | Robert Kendrick | 6 | 6 | | | | |
| 6 | Robert Kendrick | 6 | 6 | 6 | Robert Kendrick | 1 | 4 |
| | | | | 3 | Kei Nishikori | 6 | 6 |
| 3 | Kei Nishikori | 6 | 7 | 3 | Kei Nishikori | 6 | 6 |
| Q | Nicholas Monroe | 1 | 6$^4$ | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | R Sweeting | 4 | 4 | | | | | | | | | | | | | | |
| | M Yani | 6 | 6 | | | M Yani | 0 | 3 | | | | | | | | | |
| | R DeHeart | 5 | 7 | 6 | | R DeHeart | 6 | 6 | | | | | | | | | |
| Q | L Gregorc | 7 | 6$^5$ | 1 | | | | | | | R DeHeart | 4 | 2 | | | | |
| PR | A Delić | 6 | 7 | | | | | | | LL | F Wolmarans | 6 | 6 | | | | |
| | G Jones | 4 | 5 | | PR | A Delić | 1 | 2 | | | | | | | | | |
| PR | C Guccione | 4 | 4 | | LL | F Wolmarans | 6 | 6 | | | | | | | | | |
| LL | F Wolmarans | 6 | 6 | | | | | | | | | | | LL | F Wolmarans | 4 | 4 |
| 4 | P Luczak | 3 | 4 | | | | | | | | | | | 6 | R Kendrick | 6 | 6 |
| | I van der Merwe | 6 | 6 | | | I van der Merwe | 6$^1$ | 6 | 5 | | | | | | | | |
| | R de Voest | 6$^5$ | 7 | 7 | | R de Voest | 7 | 1 | 7 | | | | | | | | |
| WC | R Williams | 7 | 5 | 6$^6$ | | | | | | | R de Voest | 4 | 4 | | | | |
| | R Klaasen | 2 | 7 | 7 | | | | | | 6 | R Kendrick | 6 | 6 | | | | |
| | J Levine | 6 | 6$^4$ | 6$^7$ | | R Klaasen | 5 | 2 | | | | | | | | | |
| | A Kuznetsov | 6 | 2 | 2 | 6 | R Kendrick | 7 | 6 | | | | | | | | | |
| 6 | R Kendrick | 4 | 6 | 6 | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 8 | T Smyczek | 2 | 6$^6$ | | | | | | | | | | | | | | |
| | B Reynolds | 6 | 7 | | | B Reynolds | 7 | 6 | | | | | | | | | |
| Q | Y Bhambri | 4 | 6 | 4 | | L Cook | 6$^5$ | 3 | | | | | | | | | |
| | L Cook | 6 | 4 | 6 | | | | | | | B Reynolds | 3 | 2 | | | | |
| Q | D Martin | 7 | 6 | | | | | | | 3 | K Nishikori | 6 | 6 | | | | |
| WC | E Quigley | 6$^3$ | 4 | | Q | D Martin | 3 | 2 | | | | | | | | | |
| WC | J-P Smith | 4 | 1 | | 3 | K Nishikori | 6 | 6 | | | | | | | | | |
| 3 | K Nishikori | 6 | 6 | | | | | | | | | | | 3 | K Nishikori | 6 | 7 |
| 7 | C Ball | 6 | 6$^4$ | 6 | | | | | | | | | | Q | N Monroe | 1 | 6$^4$ |
| WC | B Čonkić | 3 | 7 | 1 | 7 | C Ball | 6$^6$ | 3 | | | | | | | | | |
| | K Kim | 1 | 4 | | Q | N Monroe | 7 | 6 | | | | | | | | | |
| Q | N Monroe | 6 | 6 | | | | | | | Q | N Monroe | 7 | 7 | | | | |
| | M McClune | 2 | 7 | 2 | | | | | | | J Witten | 6$^6$ | 6$^4$ | | | | |
| | A Bogomolov Jr. | 6 | 6$^5$ | 6 | | A Bogomolov Jr. | 6 | 4 | 6$^{11}$ | | | | | | | | |
| | J Witten | 2 | 6 | 6 | | J Witten | 2 | 6 | 7 | | | | | | | | |
| 2 | D Young | 6 | 4 | 2 | | | | | | | | | | | | | |