# 2022 Internazionali di Tennis Città di Todi – Singles

Mario Vilella Martínez was the defending champion but chose not to defend his title.
Pedro Cachin won the title after defeating Nicolás Kicker 6–4, 6–4 in the final.

## Seeds

* Pedro Cachin (champion)
* Flavio Cobolli (quarterfinals)
* Alexandre Müller (first round)
* Nino Serdarušić (second round)
* Santiago Rodríguez Taverna (quarterfinals)
* Filip Horanský (first round)
* Thiago Agustín Tirante (second round)
* Dmitry Popko (first round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| 1 | Pedro Cachin | 6$^7$ | 6 | 6 | | | | |
| WC | Francesco Passaro | 7$^9$ | 2 | 1 | | | | |
| WC | Francesco Passaro | 7$^9$ | 2 | 1 | 1 | Pedro Cachin | 6 | 6 |
| | | | | | | Nicolás Kicker | 4 | 4 |
| | Daniel Masur | 2 | 6 | 4 | | Nicolás Kicker | 4 | 4 |
| | Nicolás Kicker | 6 | 3 | 6 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | P Cachin | 6 | 7$^7$ | | | | | | | | | | | | | | | | |
| | L Klein | 2 | 6$^4$ | | 1 | P Cachin | 7$^7$ | 6 | | | | | | | | | | | |
| WC | M Gigante | 6 | 7 | | WC | M Gigante | 6$^4$ | 0 | | | | | | | | | | | |
| | F Gaio | 3 | 5 | | | | | | | 1 | P Cachin | 6 | 6 | | | | | | |
| | D Dutra da Silva | 6 | 4 | 6 | | | | | | 5 | S Rodríguez Taverna | 3 | 2 | | | | | | |
| Q | B Harris | 3 | 6 | 1 | | D Dutra da Silva | 2 | 6 | 2 | | | | | | | | | | |
| Q | R Bertola | 7 | 3 | 4 | 5 | S Rodríguez Taverna | 6 | 4 | 6 | | | | | | | | | | |
| 5 | S Rodríguez Taverna | 5 | 6 | 6 | | | | | | | | | | | 1 | P Cachin | 6$^7$ | 6 | 6 |
| 4 | N Serdarušić | 6 | 4 | 3 | | | | | | | | | | | WC | F Passaro | 7$^9$ | 2 | 1 |
| | D Ajduković | 4 | 6 | 2$^r$ | 4 | N Serdarušić | 4 | 6$^1$ | | | | | | | | | | | |
| Q | J De Loore | 6 | 4 | 1 | WC | F Passaro | 6 | 7$^7$ | | | | | | | | | | | |
| WC | F Passaro | 2 | 6 | 6 | | | | | | WC | F Passaro | 6$^3$ | 6 | 6 | | | | | |
| | GM Moroni | 4 | 5 | | | | | | | | L Darderi | 7$^7$ | 3 | 4 | | | | | |
| | L Darderi | 6 | 7 | | | L Darderi | 6 | 7$^7$ | | | | | | | | | | | |
| Q | G Fonio | 6 | 3 | 6 | Q | G Fonio | 3 | 6$^3$ | | | | | | | | | | | |
| 8 | D Popko | 4 | 6 | 1 | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 7 | TA Tirante | 4 | 6 | 6 | | | | | | | | | | | | | |
| Q | Andrey Chepelev | 6 | 3 | 2 | 7 | TA Tirante | 4 | 1 | | | | | | | | | |
| WC | M Bellucci | 3 | 7$^7$ | 2 | | D Masur | 6 | 6 | | | | | | | | | |
| | D Masur | 6 | 6$^5$ | 6 | | | | | | | D Masur | 6 | 6 | | | | |
| | E Furness | 6 | 3 | 2 | | | | | | Q | F Maestrelli | 2 | 3 | | | | |
| SE | JB Torres | 4 | 6 | 6 | SE | JB Torres | 7$^7$ | 6$^2$ | 2 | | | | | | | | |
| Q | F Maestrelli | 3 | 7$^7$ | 6 | Q | F Maestrelli | 6$^5$ | 7$^7$ | 6 | | | | | | | | |
| 3 | A Müller | 6 | 6$^2$ | 1 | | | | | | | | | | D Masur | 2 | 6 | 4 |
| 6 | F Horanský | 7 | 3 | 1 | | | | | | | | | | N Kicker | 6 | 3 | 6 |
| | T Skatov | 5 | 6 | 6 | | T Skatov | 4 | 3 | | | | | | | | | |
| | N Kicker | 3 | 7 | 1 | | N Kicker | 6 | 6 | | | | | | | | | |
| | J de Jong | 6 | 5 | 0$^r$ | | | | | | | N Kicker | 6 | 6 | | | | |
| | M Arnaldi | 3 | 4 | | | | | | | 2 | F Cobolli | 3 | 3 | | | | |
| Alt | J Sels | 6 | 6 | | Alt | J Sels | 4 | 4 | | | | | | | | | |
| | A Collarini | 3 | 3 | | 2 | F Cobolli | 6 | 6 | | | | | | | | | |
| 2 | F Cobolli | 6 | 6 | | | | | | | | | | | | | | |