# 2021–22 Women's EHF Champions League group stage

The 2021–22 Women's EHF Champions League group stage began on 11 September 2021 and concluded on 20 February 2022 to determine the ten teams who advanced to the knockout stage of the 2021–22 Women's EHF Champions League.

## Draw

The draw was held on 2 July 2020 in Vienna, Austria.

### Seeding

The composition of the seeding pots for the group stage draw was announced on 30 June 2021. From each pot, two teams were drawn into Group A and the other two in Group B. Teams from the same national association were not drawn into the same group.
Seeding pots for Groups A and B :
| Pot 1 | Pot 2 | Pot 3 | Pot 4 |
| FTC-Rail Cargo Hungaria Brest Bretagne Handball CSKA Moscow Vipers Kristiansand | CSM București Budućnost BEMAX Odense Håndbold RK Krim Mercator | BV Borussia 09 Dortmund Győri Audi ETO KC Metz Handball Rostov-Don | HC Podravka Vegeta IK Sävehof Kastamonu Bld. GSK Team Esbjerg |

## Format

In each group, teams played against each other in a double round-robin format, with home and away matches.

## Tiebreakers

In the group stage, teams were ranked according to points (2 points for a win, 1 point for a draw, 0 points for a loss). After completion of the group stage, if two or more teams have the same number of points, the ranking is determined as follows:
* Highest number of points in matches between the teams directly involved;
* Superior goal difference in matches between the teams directly involved;
* Highest number of goals scored in matches between the teams directly involved (or in the away match in case of a two-team tie);
* Superior goal difference in all matches of the group;
* Highest number of plus goals in all matches of the group;
If the ranking of one of these teams is determined, the above criteria are consecutively followed until the ranking of all teams is determined. If no ranking can be determined, a decision shall be obtained by EHF through drawing of lots.

## Groups

The matchdays were 11–12 September, 18–19 September, 25–26 September, 16–17 October, 23–24 October, 30–31 October, 13–14 November, 20–21 November 2021, 8–9 January, 15–16 January, 22–23 January, 5–6 February, 12–13 February, 19–20 February 2021.
Times until 30 October 2021 are UTC+2, from 31 October 2021 on times are UTC+1.
Due to the COVID-19 pandemic, each local health department allows a different number of spectators.

### Group A

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification |
| 1 | Team Esbjerg | 14 | 10 | 3 | 1 | 412 | 346 | +66 | 23 | Quarterfinals |
| 2 | Rostov-Don | 14 | 10 | 1 | 3 | 362 | 302 | +60 | 21 | Quarterfinals |
| 3 | FTC-Rail Cargo Hungaria | 14 | 8 | 3 | 3 | 378 | 372 | +6 | 19 | Playoffs |
| 4 | Brest Bretagne Handball | 14 | 8 | 1 | 5 | 392 | 365 | +27 | 17 | Playoffs |
| 5 | CSM București | 14 | 7 | 1 | 6 | 365 | 342 | +23 | 15 | Playoffs |
| 6 | BV Borussia 09 Dortmund | 14 | 4 | 1 | 9 | 391 | 399 | −8 | 9 | Playoffs |
| 7 | Budućnost BEMAX | 14 | 3 | 0 | 11 | 337 | 407 | −70 | 6 | |
| 8 | HC Podravka Vegeta | 14 | 1 | 0 | 13 | 334 | 438 | −104 | 2 | |
| 11 September 2021 16:00 | BV Borussia 09 Dortmund | 25–25 | FTC-Rail Cargo Hungaria | Helmut-Körnig-Halle, Dortmund Attendance: 150 Referees: Christiansen, Hansen (DEN) |
| 11 September 2021 16:00 | Grijseels 9 | (12–14) | Bölk, Malestein 6 | Helmut-Körnig-Halle, Dortmund Attendance: 150 Referees: Christiansen, Hansen (DEN) |
| 11 September 2021 16:00 | 1× 2× | Report | 2× 5× | Helmut-Körnig-Halle, Dortmund Attendance: 150 Referees: Christiansen, Hansen (DEN) |
| 11 September 2021 16:00 | Rostov-Don | 26–24 | Brest Bretagne Handball | Rostov-on-Don Palace of Sports, Rostov-on-Don Attendance: 1,177 Referees: Antić, Jakovljević (SRB) |
| 11 September 2021 16:00 | Frolova 6 | (16–13) | Jauković 6 | Rostov-on-Don Palace of Sports, Rostov-on-Don Attendance: 1,177 Referees: Antić, Jakovljević (SRB) |
| 11 September 2021 16:00 | 1× 4× | Report | 4× | Rostov-on-Don Palace of Sports, Rostov-on-Don Attendance: 1,177 Referees: Antić, Jakovljević (SRB) |
| 11 September 2021 18:00 | HC Podravka Vegeta | 29–22 | Budućnost BEMAX | ŠSD "Josip Samaržija-Bepo", Koprivnica Attendance: 300 Referees: Backović, Palačković (SLO) |
| 11 September 2021 18:00 | Milosavljević, Kalaus 6 | (22–12) | Maslova 8 | ŠSD "Josip Samaržija-Bepo", Koprivnica Attendance: 300 Referees: Backović, Palačković (SLO) |
| 11 September 2021 18:00 | 2× 7× | Report | 3× | ŠSD "Josip Samaržija-Bepo", Koprivnica Attendance: 300 Referees: Backović, Palačković (SLO) |
| 12 September 2021 14:00 | Team Esbjerg | 22–21 | CSM București | Blue Water Dokken, Esbjerg Attendance: 1,850 Referees: Vranes, Wenninger (AUT) |
| 12 September 2021 14:00 | Reistad, Tranborg 5 | (13–10) | Omoregie 5 | Blue Water Dokken, Esbjerg Attendance: 1,850 Referees: Vranes, Wenninger (AUT) |
| 12 September 2021 14:00 | 1× 3× | Report | 1× 4× | Blue Water Dokken, Esbjerg Attendance: 1,850 Referees: Vranes, Wenninger (AUT) |
| 18 September 2021 16:00 | FTC-Rail Cargo Hungaria | 33–27 | HC Podravka Vegeta | Érd Aréna, Érd Attendance: 1,200 Referees: Konjičanin, Konjičanin (BIH) |
| 18 September 2021 16:00 | Malestein 9 | (15–15) | Milosavljević, Mugoša 5 | Érd Aréna, Érd Attendance: 1,200 Referees: Konjičanin, Konjičanin (BIH) |
| 18 September 2021 16:00 | 4× | Report | 3× | Érd Aréna, Érd Attendance: 1,200 Referees: Konjičanin, Konjičanin (BIH) |
| 18 September 2021 16:00 | CSM București | 27–30 | Rostov-Don | Polyvalent Hall, Bucharest Attendance: 1,200 Referees: Covalciuc, Covalciuc (MDA) |
| 18 September 2021 16:00 | Arntzen 8 | (9–13) | six players 4 | Polyvalent Hall, Bucharest Attendance: 1,200 Referees: Covalciuc, Covalciuc (MDA) |
| 18 September 2021 16:00 | 1× 3× | Report | 4× | Polyvalent Hall, Bucharest Attendance: 1,200 Referees: Covalciuc, Covalciuc (MDA) |
| 18 September 2021 18:00 | Brest Bretagne Handball | 26–23 | Team Esbjerg | Brest Arena, Brest Attendance: 2,410 Referees: Barysas, Petrušis (LTU) |
| 18 September 2021 18:00 | three players 4 | (13–9) | Reistad 6 | Brest Arena, Brest Attendance: 2,410 Referees: Barysas, Petrušis (LTU) |
| 18 September 2021 18:00 | 1× | Report | 3× | Brest Arena, Brest Attendance: 2,410 Referees: Barysas, Petrušis (LTU) |
| 19 September 2021 16:00 | Budućnost BEMAX | 29–34 | BV Borussia 09 Dortmund | Bemax Hall, Podgorica Attendance: 100 Referees: Alpaidze, Berezkina (RUS) |
| 19 September 2021 16:00 | Pletikosić 7 | (15–18) | Grijseels 11 | Bemax Hall, Podgorica Attendance: 100 Referees: Alpaidze, Berezkina (RUS) |
| 19 September 2021 16:00 | 1× 5× | Report | 1× 3× | Bemax Hall, Podgorica Attendance: 100 Referees: Alpaidze, Berezkina (RUS) |
| 25 September 2021 16:00 | Rostov-Don | 19–20 | FTC-Rail Cargo Hungaria | Rostov-on-Don Palace of Sports, Rostov-on-Don Attendance: 2,751 Referees: Hatipoğlu, Şimşek (TUR) |
| 25 September 2021 16:00 | Managarova 5 | (8–11) | Bölk 6 | Rostov-on-Don Palace of Sports, Rostov-on-Don Attendance: 2,751 Referees: Hatipoğlu, Şimşek (TUR) |
| 25 September 2021 16:00 | 2× 1× | Report | 3× 5× | Rostov-on-Don Palace of Sports, Rostov-on-Don Attendance: 2,751 Referees: Hatipoğlu, Şimşek (TUR) |
| 25 September 2021 18:00 | BV Borussia 09 Dortmund | 30–27 | Brest Bretagne Handball | Helmut-Körnig-Halle, Dortmund Attendance: 120 Referees: Lindenbaum, Laron (ISR) |
| 25 September 2021 18:00 | Grijseels 9 | (15–9) | Niakaté 7 | Helmut-Körnig-Halle, Dortmund Attendance: 120 Referees: Lindenbaum, Laron (ISR) |
| 25 September 2021 18:00 | 1× 2× | Report | 2× 2× | Helmut-Körnig-Halle, Dortmund Attendance: 120 Referees: Lindenbaum, Laron (ISR) |
| 25 September 2021 18:00 | HC Podravka Vegeta | 31–36 | CSM București | ŠSD "Josip Samaržija-Bepo", Koprivnica Attendance: 250 Referees: Duplii, Pobedrina (UKR) |
| 25 September 2021 18:00 | Kalaus, Milosavljević 7 | (15–16) | Neagu 14 | ŠSD "Josip Samaržija-Bepo", Koprivnica Attendance: 250 Referees: Duplii, Pobedrina (UKR) |
| 25 September 2021 18:00 | 2× 4× | Report | 5× | ŠSD "Josip Samaržija-Bepo", Koprivnica Attendance: 250 Referees: Duplii, Pobedrina (UKR) |
| 26 September 2021 14:00 | Team Esbjerg | 35–20 | Budućnost BEMAX | Blue Water Dokken, Esbjerg Attendance: 1,783 Referees: Lidacka, Lesiak (POL) |
| 26 September 2021 14:00 | Türkoglu 6 | (16–10) | Pavićević 5 | Blue Water Dokken, Esbjerg Attendance: 1,783 Referees: Lidacka, Lesiak (POL) |
| 26 September 2021 14:00 | 1× 2× | Report | 4× | Blue Water Dokken, Esbjerg Attendance: 1,783 Referees: Lidacka, Lesiak (POL) |
| 16 October 2021 16:00 | FTC-Rail Cargo Hungaria | 31–31 | Team Esbjerg | Érd Aréna, Érd Attendance: 1,600 Referees: Antić, Jakovljević (SRB) |
| 16 October 2021 16:00 | Malestein 10 | (16–16) | Reistad 10 | Érd Aréna, Érd Attendance: 1,600 Referees: Antić, Jakovljević (SRB) |
| 16 October 2021 16:00 | 1× 3× | Report | 1× 3× | Érd Aréna, Érd Attendance: 1,600 Referees: Antić, Jakovljević (SRB) |
| 16 October 2021 18:00 | Brest Bretagne Handball | 35–22 | HC Podravka Vegeta | Brest Arena, Brest Attendance: 3,301 Referees: Doychinov, Goretsov (BUL) |
| 16 October 2021 18:00 | Foppa 7 | (17–9) | Milosavljević 6 | Brest Arena, Brest Attendance: 3,301 Referees: Doychinov, Goretsov (BUL) |
| 16 October 2021 18:00 | 3× | Report | 1× 5× 1× | Brest Arena, Brest Attendance: 3,301 Referees: Doychinov, Goretsov (BUL) |
| 17 October 2021 16:00 | Budućnost BEMAX | 19–25 | Rostov-Don | Bemax Hall, Podgorica Attendance: 100 Referees: Ilieva, Karbeska (MKD) |
| 17 October 2021 16:00 | Pletikosić 5 | (10–14) | Sen, Zaadi 6 | Bemax Hall, Podgorica Attendance: 100 Referees: Ilieva, Karbeska (MKD) |
| 17 October 2021 16:00 | 2× 1× | Report | 3× 1× | Bemax Hall, Podgorica Attendance: 100 Referees: Ilieva, Karbeska (MKD) |
| 17 October 2021 16:00 | BV Borussia 09 Dortmund | 22–25 | CSM București | Helmut-Körnig-Halle, Dortmund Attendance: 450 Referees: Erdoğan, Özdeniz (TUR) |
| 17 October 2021 16:00 | Bermejo, Zschocke 5 | (11–12) | Neagu 6 | Helmut-Körnig-Halle, Dortmund Attendance: 450 Referees: Erdoğan, Özdeniz (TUR) |
| 17 October 2021 16:00 | 1× 2× | Report | 1× 5× | Helmut-Körnig-Halle, Dortmund Attendance: 450 Referees: Erdoğan, Özdeniz (TUR) |
| 23 October 2021 16:00 | FTC-Rail Cargo Hungaria | 28–27 | Brest Bretagne Handball | Érd Aréna, Érd Attendance: 1,800 Referees: Alpaidze, Berezkina (RUS) |
| 23 October 2021 16:00 | Bölk 8 | (15–17) | Toublanc 8 | Érd Aréna, Érd Attendance: 1,800 Referees: Alpaidze, Berezkina (RUS) |
| 23 October 2021 16:00 | 1× 2× | Report | 1× | Érd Aréna, Érd Attendance: 1,800 Referees: Alpaidze, Berezkina (RUS) |
| 23 October 2021 16:00 | Rostov-Don | 37–27 | BV Borussia 09 Dortmund | Rostov-on-Don Palace of Sports, Rostov-on-Don Attendance: 2,357 Referees: Konjičanin, Konjičanin (BIH) |
| 23 October 2021 16:00 | Zaadi 8 | (17–11) | Zschocke 6 | Rostov-on-Don Palace of Sports, Rostov-on-Don Attendance: 2,357 Referees: Konjičanin, Konjičanin (BIH) |
| 23 October 2021 16:00 | 1× 4× | Report | 3× | Rostov-on-Don Palace of Sports, Rostov-on-Don Attendance: 2,357 Referees: Konjičanin, Konjičanin (BIH) |
| 23 October 2021 18:00 | HC Podravka Vegeta | 26–27 | Team Esbjerg | ŠSD "Josip Samaržija-Bepo", Koprivnica Attendance: 200 Referees: Covalciuc, Covalciuc (MDA) |
| 23 October 2021 18:00 | Milosavljević 7 | (9–15) | Breistøl 8 | ŠSD "Josip Samaržija-Bepo", Koprivnica Attendance: 200 Referees: Covalciuc, Covalciuc (MDA) |
| 23 October 2021 18:00 | 3× 4× | Report | 3× | ŠSD "Josip Samaržija-Bepo", Koprivnica Attendance: 200 Referees: Covalciuc, Covalciuc (MDA) |
| 24 October 2021 14:00 | CSM București | 30–22 | Budućnost BEMAX | Polyvalent Hall, Bucharest Attendance: 1,800 Referees: Christidi, Papamattheou (GRE) |
| 24 October 2021 14:00 | Neagu 6 | (14–10) | Pletikosić 5 | Polyvalent Hall, Bucharest Attendance: 1,800 Referees: Christidi, Papamattheou (GRE) |
| 24 October 2021 14:00 | 1× 2× | Report | 1× 3× | Polyvalent Hall, Bucharest Attendance: 1,800 Referees: Christidi, Papamattheou (GRE) |
| 30 October 2021 16:00 | CSM București | 29–30 | Brest Bretagne Handball | Polyvalent Hall, Bucharest Attendance: 0 Referees: Christiansen, Hansen (DEN) |
| 30 October 2021 16:00 | Neagu 10 | (16–14) | Niakaté 10 | Polyvalent Hall, Bucharest Attendance: 0 Referees: Christiansen, Hansen (DEN) |
| 30 October 2021 16:00 | 2× 5× | Report | 4× | Polyvalent Hall, Bucharest Attendance: 0 Referees: Christiansen, Hansen (DEN) |
| 30 October 2021 18:00 | Budućnost BEMAX | 26–30 | FTC-Rail Cargo Hungaria | Morača Sports Center, Podgorica Attendance: 300 Referees: Duplii, Pobedrina (UKR) |
| 30 October 2021 18:00 | Pletikosić 7 | (13–13) | Malestein 9 | Morača Sports Center, Podgorica Attendance: 300 Referees: Duplii, Pobedrina (UKR) |
| 30 October 2021 18:00 | 5× | Report | 3× 3× | Morača Sports Center, Podgorica Attendance: 300 Referees: Duplii, Pobedrina (UKR) |
| 31 October 2021 14:00 | BV Borussia 09 Dortmund | 38–14 | HC Podravka Vegeta | Helmut-Körnig-Halle, Dortmund Attendance: 450 Referees: Christidi, Papamattheou (GRE) |
| 31 October 2021 14:00 | Grijseels 15 | (16–8) | Kalaus 9 | Helmut-Körnig-Halle, Dortmund Attendance: 450 Referees: Christidi, Papamattheou (GRE) |
| 31 October 2021 14:00 | 1× 3× | Report | 2× 4× | Helmut-Körnig-Halle, Dortmund Attendance: 450 Referees: Christidi, Papamattheou (GRE) |
| 31 October 2021 14:00 | Team Esbjerg | 25–18 | Rostov-Don | Blue Water Dokken, Esbjerg Attendance: 2,014 Referees: Simone, Monitillo (ITA) |
| 31 October 2021 14:00 | Røsberg Jacobsen 8 | (13–10) | Zaadi 5 | Blue Water Dokken, Esbjerg Attendance: 2,014 Referees: Simone, Monitillo (ITA) |
| 31 October 2021 14:00 | 2× 4× | Report | 3× 3× | Blue Water Dokken, Esbjerg Attendance: 2,014 Referees: Simone, Monitillo (ITA) |
| 13 November 2021 16:00 | FTC-Rail Cargo Hungaria | 31–30 | CSM București | Érd Aréna, Érd Attendance: 2,200 Referees: Álvarez, Bustamante (ESP) |
| 13 November 2021 16:00 | Grbić 6 | (20–16) | Neagu 7 | Érd Aréna, Érd Attendance: 2,200 Referees: Álvarez, Bustamante (ESP) |
| 13 November 2021 16:00 | 1× 3× | Report | 3× | Érd Aréna, Érd Attendance: 2,200 Referees: Álvarez, Bustamante (ESP) |
| 13 November 2021 18:00 | Brest Bretagne Handball | 25–21 | Budućnost BEMAX | Brest Arena, Brest Attendance: 3,552 Referees: Hatipoğlu, Şimşek (TUR) |
| 13 November 2021 18:00 | Toublanc 10 | (12–12) | Kepic 5 | Brest Arena, Brest Attendance: 3,552 Referees: Hatipoğlu, Şimşek (TUR) |
| 13 November 2021 18:00 | 1× 4× | Report | 1× 5× | Brest Arena, Brest Attendance: 3,552 Referees: Hatipoğlu, Şimşek (TUR) |
| 13 November 2021 18:00 | HC Podravka Vegeta | 22–23 | Rostov-Don | ŠSD "Josip Samaržija-Bepo", Koprivnica Attendance: 250 Referees: Erdoğan, Özdeniz (TUR) |
| 13 November 2021 18:00 | Bazaliu 7 | (13–13) | Managarova, Zaadi 5 | ŠSD "Josip Samaržija-Bepo", Koprivnica Attendance: 250 Referees: Erdoğan, Özdeniz (TUR) |
| 13 November 2021 18:00 | 4× 4× | Report | 2× 1× | ŠSD "Josip Samaržija-Bepo", Koprivnica Attendance: 250 Referees: Erdoğan, Özdeniz (TUR) |
| 14 November 2021 14:00 | BV Borussia 09 Dortmund | 29–32 | Team Esbjerg | Helmut-Körnig-Halle, Dortmund Attendance: 650 Referees: Sekulić, Jovandić (SRB) |
| 14 November 2021 14:00 | Grijseels 8 | (14–20) | Breistøl, Ingstad 8 | Helmut-Körnig-Halle, Dortmund Attendance: 650 Referees: Sekulić, Jovandić (SRB) |
| 14 November 2021 14:00 | 1× 2× | Report | 1× 4× | Helmut-Körnig-Halle, Dortmund Attendance: 650 Referees: Sekulić, Jovandić (SRB) |
| 20 November 2021 16:00 | CSM București | 27–21 | FTC-Rail Cargo Hungaria | Polyvalent Hall, Bucharest Attendance: 0 Referees: Gasmi, Gasmi (FRA) |
| 20 November 2021 16:00 | Neagu 9 | (16–11) | Bölk 9 | Polyvalent Hall, Bucharest Attendance: 0 Referees: Gasmi, Gasmi (FRA) |
| 20 November 2021 16:00 | 1× 2× | Report | 2× 2× | Polyvalent Hall, Bucharest Attendance: 0 Referees: Gasmi, Gasmi (FRA) |
| 20 November 2021 16:00 | Rostov-Don | 34–23 | HC Podravka Vegeta | Rostov-on-Don Palace of Sports, Rostov-on-Don Attendance: 500 Referees: Metalari, Nikolovski (MKD) |
| 20 November 2021 16:00 | Zaadi 8 | (18–12) | Bazaliu, Kalaus 6 | Rostov-on-Don Palace of Sports, Rostov-on-Don Attendance: 500 Referees: Metalari, Nikolovski (MKD) |
| 20 November 2021 16:00 | 1× 2× | Report | 2× 3× | Rostov-on-Don Palace of Sports, Rostov-on-Don Attendance: 500 Referees: Metalari, Nikolovski (MKD) |
| 20 November 2021 18:00 | Budućnost BEMAX | 30–28 | Brest Bretagne Handball | Morača Sports Center, Podgorica Attendance: 500 Referees: Covalciuc, Covalciuc (MDA) |
| 20 November 2021 18:00 | Pletikosić 12 | (13–16) | Gigstad Fauske 9 | Morača Sports Center, Podgorica Attendance: 500 Referees: Covalciuc, Covalciuc (MDA) |
| 20 November 2021 18:00 | 2× 3× | Report | 1× 3× | Morača Sports Center, Podgorica Attendance: 500 Referees: Covalciuc, Covalciuc (MDA) |
| 21 November 2021 16:00 | Team Esbjerg | 34–24 | BV Borussia 09 Dortmund | Blue Water Dokken, Esbjerg Attendance: 2,031 Referees: Bolic, Hurich (AUT) |
| 21 November 2021 16:00 | Breistøl, Røsberg Jacobsen 7 | (18–13) | Sando 7 | Blue Water Dokken, Esbjerg Attendance: 2,031 Referees: Bolic, Hurich (AUT) |
| 21 November 2021 16:00 | | Report | 2× | Blue Water Dokken, Esbjerg Attendance: 2,031 Referees: Bolic, Hurich (AUT) |
| 8 January 2022 16:00 | FTC-Rail Cargo Hungaria | 26–22 | Budućnost BEMAX | Érd Aréna, Érd Attendance: 2,000 Referees: Backović, Palačković (SLO) |
| 8 January 2022 16:00 | Bölk 8 | (18–11) | Bulatović 6 | Érd Aréna, Érd Attendance: 2,000 Referees: Backović, Palačković (SLO) |
| 8 January 2022 16:00 | 1× 3× | Report | 2× 5× | Érd Aréna, Érd Attendance: 2,000 Referees: Backović, Palačković (SLO) |
| 8 January 2022 16:00 | Rostov-Don | 25–27 | Team Esbjerg | Rostov-on-Don Palace of Sports, Rostov-on-Don Attendance: 497 Referees: Jović, Arnautović (BIH) |
| 8 January 2022 16:00 | Zaadi 6 | (15–12) | Frafjord 6 | Rostov-on-Don Palace of Sports, Rostov-on-Don Attendance: 497 Referees: Jović, Arnautović (BIH) |
| 8 January 2022 16:00 | 1× 1× | Report | 1× 2× | Rostov-on-Don Palace of Sports, Rostov-on-Don Attendance: 497 Referees: Jović, Arnautović (BIH) |
| 9 January 2022 14:00 | HC Podravka Vegeta | 24–32 | BV Borussia 09 Dortmund | ŠSD "Josip Samaržija-Bepo", Koprivnica Attendance: 400 Referees: Hatipoğlu, Şimşek (TUR) |
| 9 January 2022 14:00 | Milosavljević 7 | (10–17) | Freriks 6 | ŠSD "Josip Samaržija-Bepo", Koprivnica Attendance: 400 Referees: Hatipoğlu, Şimşek (TUR) |
| 9 January 2022 14:00 | 2× 7× | Report | 1× 3× | ŠSD "Josip Samaržija-Bepo", Koprivnica Attendance: 400 Referees: Hatipoğlu, Şimşek (TUR) |
| 15 January 2022 18:00 | Budućnost BEMAX | 20–28 | CSM București | Morača Sports Center, Podgorica Attendance: 0 Referees: Mitrevski, Todorovski (MKD) |
| 15 January 2022 18:00 | Pavićević 7 | (9–15) | Neagu 7 | Morača Sports Center, Podgorica Attendance: 0 Referees: Mitrevski, Todorovski (MKD) |
| 15 January 2022 18:00 | 2× 4× | Report | 1× 3× | Morača Sports Center, Podgorica Attendance: 0 Referees: Mitrevski, Todorovski (MKD) |
| 15 January 2022 18:00 | BV Borussia 09 Dortmund | 25–31 | Rostov-Don | Helmut-Körnig-Halle, Dortmund Attendance: 400 Referees: Lidacka, Lesiak (POL) |
| 15 January 2022 18:00 | Kücükyildiz 7 | (12–17) | Managarova, Zaadi 8 | Helmut-Körnig-Halle, Dortmund Attendance: 400 Referees: Lidacka, Lesiak (POL) |
| 15 January 2022 18:00 | 4× 1× | Report | 1× 3× | Helmut-Körnig-Halle, Dortmund Attendance: 400 Referees: Lidacka, Lesiak (POL) |
| 19 January 2022 20:45 | Brest Bretagne Handball | 24–21 | CSM București | Brest Arena, Brest Attendance: 2,000 Referees: Duplii, Pobedrina (UKR) |
| 19 January 2022 20:45 | Coatanea 5 | (11–11) | Neagu 7 | Brest Arena, Brest Attendance: 2,000 Referees: Duplii, Pobedrina (UKR) |
| 19 January 2022 20:45 | 1× 2× | Report | 1× 5× | Brest Arena, Brest Attendance: 2,000 Referees: Duplii, Pobedrina (UKR) |
| 22 January 2022 16:00 | CSM București | 33–29 | BV Borussia 09 Dortmund | Polyvalent Hall, Bucharest Attendance: 1,800 Referees: Sá, Sá (POR) |
| 22 January 2022 16:00 | Neagu 11 | (16–14) | Berger 6 | Polyvalent Hall, Bucharest Attendance: 1,800 Referees: Sá, Sá (POR) |
| 22 January 2022 16:00 | 1× 4× | Report | 1× 4× | Polyvalent Hall, Bucharest Attendance: 1,800 Referees: Sá, Sá (POR) |
| 22 January 2022 16:00 | Rostov-Don | 30–20 | Budućnost BEMAX | Rostov-on-Don Palace of Sports, Rostov-on-Don Attendance: 500 Referees: Nabokau, Kulik (BLR) |
| 22 January 2022 16:00 | Bobrovnikova, Kozhokar 5 | (12–9) | Vukčević 5 | Rostov-on-Don Palace of Sports, Rostov-on-Don Attendance: 500 Referees: Nabokau, Kulik (BLR) |
| 22 January 2022 16:00 | 1× 5× | Report | 1× 6× | Rostov-on-Don Palace of Sports, Rostov-on-Don Attendance: 500 Referees: Nabokau, Kulik (BLR) |
| 23 January 2022 14:00 | Team Esbjerg | 33–27 | FTC-Rail Cargo Hungaria | Blue Water Dokken, Esbjerg Attendance: 1,260 Referees: Braseth, Sundet (NOR) |
| 23 January 2022 14:00 | Reistad 13 | (14–13) | Kisfaludy, Malestein 6 | Blue Water Dokken, Esbjerg Attendance: 1,260 Referees: Braseth, Sundet (NOR) |
| 23 January 2022 14:00 | 1× 2× | Report | 2× 5× | Blue Water Dokken, Esbjerg Attendance: 1,260 Referees: Braseth, Sundet (NOR) |
| 23 January 2022 14:00 | HC Podravka Vegeta | 28–39 | Brest Bretagne Handball | ŠSD "Josip Samaržija-Bepo", Koprivnica Attendance: 200 Referees: Tzaferopoulos, Bethmann (GRE) |
| 23 January 2022 14:00 | Milosavljević 7 | (16–17) | Gigstad Fauske 11 | ŠSD "Josip Samaržija-Bepo", Koprivnica Attendance: 200 Referees: Tzaferopoulos, Bethmann (GRE) |
| 23 January 2022 14:00 | 5× | Report | 1× 3× | ŠSD "Josip Samaržija-Bepo", Koprivnica Attendance: 200 Referees: Tzaferopoulos, Bethmann (GRE) |
| 29 January 2022 16:00 | Team Esbjerg | 30–17 | HC Podravka Vegeta | Blue Water Dokken, Esbjerg Attendance: 1,180 Referees: Kijauskaitė, Žalienė (LTU) |
| 29 January 2022 16:00 | Solberg-Isaksen 7 | (18–7) | Stelmakh 5 | Blue Water Dokken, Esbjerg Attendance: 1,180 Referees: Kijauskaitė, Žalienė (LTU) |
| 29 January 2022 16:00 | 3× | Report | 2× 5× | Blue Water Dokken, Esbjerg Attendance: 1,180 Referees: Kijauskaitė, Žalienė (LTU) |
| 29 January 2022 20:00 | Brest Bretagne Handball | 30–25 | FTC-Rail Cargo Hungaria | Brest Arena, Brest Attendance: 2,000 Referees: Erdoğan, Özdeniz (TUR) |
| 29 January 2022 20:00 | Gigstad Fauske 13 | (19–16) | Malestein 10 | Brest Arena, Brest Attendance: 2,000 Referees: Erdoğan, Özdeniz (TUR) |
| 29 January 2022 20:00 | 2× 3× | Report | 2× 4× 1× | Brest Arena, Brest Attendance: 2,000 Referees: Erdoğan, Özdeniz (TUR) |
| 5 February 2022 16:00 | Brest Bretagne Handball | 31–25 | BV Borussia 09 Dortmund | Brest Arena, Brest Attendance: 3,455 Referees: Yovchev, Yonchev (BUL) |
| 5 February 2022 16:00 | Toublanc 6 | (17–10) | Rønning, Van Zijl 5 | Brest Arena, Brest Attendance: 3,455 Referees: Yovchev, Yonchev (BUL) |
| 5 February 2022 16:00 | 1× 1× | Report | 1× 5× | Brest Arena, Brest Attendance: 3,455 Referees: Yovchev, Yonchev (BUL) |
| 5 February 2022 16:00 | FTC-Rail Cargo Hungaria | 25–25 | Rostov-Don | Érd Aréna, Érd Attendance: 1,800 Referees: Christidi, Papamattheou (GRE) |
| 5 February 2022 16:00 | Szöllősi-Zácsik 7 | (13–13) | Managarova 7 | Érd Aréna, Érd Attendance: 1,800 Referees: Christidi, Papamattheou (GRE) |
| 5 February 2022 16:00 | 1× 3× | Report | 2× | Érd Aréna, Érd Attendance: 1,800 Referees: Christidi, Papamattheou (GRE) |
| 5 February 2022 18:00 | Budućnost BEMAX | 25–36 | Team Esbjerg | Morača Sports Center, Podgorica Attendance: 500 Referees: Praštalo, Balvan (BIH) |
| 5 February 2022 18:00 | Pavićević, Pletikosić 6 | (13–14) | Kamp 8 | Morača Sports Center, Podgorica Attendance: 500 Referees: Praštalo, Balvan (BIH) |
| 5 February 2022 18:00 | 2× 3× | Report | 2× | Morača Sports Center, Podgorica Attendance: 500 Referees: Praštalo, Balvan (BIH) |
| 6 February 2022 16:00 | CSM București | 29–21 | HC Podravka Vegeta | Polyvalent Hall, Bucharest Attendance: 1,350 Referees: Ilieva, Karbeska (MKD) |
| 6 February 2022 16:00 | Arntzen, Omoregie 5 | (19–10) | Mugoša 7 | Polyvalent Hall, Bucharest Attendance: 1,350 Referees: Ilieva, Karbeska (MKD) |
| 6 February 2022 16:00 | 2× 3× | Report | 1× 2× | Polyvalent Hall, Bucharest Attendance: 1,350 Referees: Ilieva, Karbeska (MKD) |
| 13 February 2022 16:00 | BV Borussia 09 Dortmund | 30–34 | Budućnost BEMAX | Helmut-Körnig-Halle, Dortmund Attendance: 500 Referees: Vranes, Wenninger (AUT) |
| 13 February 2022 16:00 | Van der Heijden 8 | (18–16) | Maslova 10 | Helmut-Körnig-Halle, Dortmund Attendance: 500 Referees: Vranes, Wenninger (AUT) |
| 13 February 2022 16:00 | 2× | Report | 1× 6× | Helmut-Körnig-Halle, Dortmund Attendance: 500 Referees: Vranes, Wenninger (AUT) |
| 13 February 2022 16:00 | Team Esbjerg | 28–28 | Brest Bretagne Handball | Blue Water Dokken, Esbjerg Attendance: 2,135 Referees: Backović, Palačković (SLO) |
| 13 February 2022 16:00 | Breistøl 8 | (15–16) | Toublanc 7 | Blue Water Dokken, Esbjerg Attendance: 2,135 Referees: Backović, Palačković (SLO) |
| 13 February 2022 16:00 | 4× | Report | 3× 6× | Blue Water Dokken, Esbjerg Attendance: 2,135 Referees: Backović, Palačković (SLO) |
| 16 February 2022 17:00 | HC Podravka Vegeta | 29–33 | FTC-Rail Cargo Hungaria | ŠSD "Josip Samaržija-Bepo", Koprivnica Attendance: 200 Referees: Sekulić, Jovandić (SRB) |
| 16 February 2022 17:00 | Milosavljević 11 | (16–15) | Szöllősi-Zácsik 7 | ŠSD "Josip Samaržija-Bepo", Koprivnica Attendance: 200 Referees: Sekulić, Jovandić (SRB) |
| 16 February 2022 17:00 | 2× 3× | Report | 1× 5× | ŠSD "Josip Samaržija-Bepo", Koprivnica Attendance: 200 Referees: Sekulić, Jovandić (SRB) |
| 19 February 2022 16:00 | FTC-Rail Cargo Hungaria | 23–21 | BV Borussia 09 Dortmund | Érd Aréna, Érd Attendance: 2,000 Referees: Duplii, Pobedrina (UKR) |
| 19 February 2022 16:00 | Stolle, Szöllősi-Zácsik 4 | (12–11) | Van der Heijden 4 | Érd Aréna, Érd Attendance: 2,000 Referees: Duplii, Pobedrina (UKR) |
| 19 February 2022 16:00 | 2× 5× | Report | 1× 2× | Érd Aréna, Érd Attendance: 2,000 Referees: Duplii, Pobedrina (UKR) |
| 19 February 2022 18:00 | Brest Bretagne Handball | 18–29 | Rostov-Don | Brest Arena, Brest Attendance: 4,101 Referees: Merz, Kuttler (GER) |
| 19 February 2022 18:00 | Toublanc 6 | (9–17) | Zaadi 9 | Brest Arena, Brest Attendance: 4,101 Referees: Merz, Kuttler (GER) |
| 19 February 2022 18:00 | 3× 4× | Report | 2× 3× | Brest Arena, Brest Attendance: 4,101 Referees: Merz, Kuttler (GER) |
| 19 February 2022 18:00 | Budućnost BEMAX | 27–21 | HC Podravka Vegeta | Bemax Hall, Podgorica Attendance: 600 Referees: Christidi, Papamattheou (GRE) |
| 19 February 2022 18:00 | Pletikosić 12 | (13–13) | Milosavljević 7 | Bemax Hall, Podgorica Attendance: 600 Referees: Christidi, Papamattheou (GRE) |
| 19 February 2022 18:00 | 2× 3× | Report | 2× 4× | Bemax Hall, Podgorica Attendance: 600 Referees: Christidi, Papamattheou (GRE) |
| 20 February 2022 14:00 | CSM București | 29–29 | Team Esbjerg | Polyvalent Hall, Bucharest Attendance: 1,250 Referees: Antić, Jakovljević (SRB) |
| 20 February 2022 14:00 | Neagu 10 | (15–16) | Reistad 9 | Polyvalent Hall, Bucharest Attendance: 1,250 Referees: Antić, Jakovljević (SRB) |
| 20 February 2022 14:00 | 1× 2× | Report | 1× 3× | Polyvalent Hall, Bucharest Attendance: 1,250 Referees: Antić, Jakovljević (SRB) |
| Cancelled | Rostov-Don | 10–0 | CSM București |

### Group B

| Pos | Team | Pld | W | D | L | GF | GA | GD | Pts | Qualification |
| 1 | Győri Audi ETO KC | 14 | 13 | 0 | 1 | 471 | 354 | +117 | 26 | Quarterfinals |
| 2 | Vipers Kristiansand | 14 | 10 | 0 | 4 | 435 | 370 | +65 | 20 | Quarterfinals |
| 3 | Metz Handball | 14 | 9 | 1 | 4 | 413 | 375 | +38 | 19 | Playoffs |
| 4 | CSKA Moscow | 14 | 7 | 2 | 5 | 375 | 372 | +3 | 16 | Playoffs |
| 5 | Odense Håndbold | 14 | 7 | 1 | 6 | 405 | 386 | +19 | 15 | Playoffs |
| 6 | RK Krim Mercator | 14 | 4 | 2 | 8 | 362 | 381 | −19 | 10 | Playoffs |
| 7 | IK Sävehof | 14 | 3 | 0 | 11 | 351 | 461 | −110 | 6 | |
| 8 | Kastamonu Bld. GSK | 14 | 0 | 0 | 14 | 349 | 462 | −113 | 0 | |
| 11 September 2021 18:00 | Győri Audi ETO KC | 35–29 | Vipers Kristiansand | Audi Aréna, Győr Attendance: 3,862 Referees: Gasmi, Gasmi (FRA) |
| 11 September 2021 18:00 | Lukács 7 | (17–13) | Valle Dahl 12 | Audi Aréna, Győr Attendance: 3,862 Referees: Gasmi, Gasmi (FRA) |
| 11 September 2021 18:00 | 3× | Report | 5× | Audi Aréna, Győr Attendance: 3,862 Referees: Gasmi, Gasmi (FRA) |
| 12 September 2021 14:00 | IK Sävehof | 29–28 | RK Krim Mercator | Partille Arena, Partille Attendance: 600 Referees: Sá, Sá (POR) |
| 12 September 2021 14:00 | Roberts 10 | (11–13) | Stanko 7 | Partille Arena, Partille Attendance: 600 Referees: Sá, Sá (POR) |
| 12 September 2021 14:00 | 3× 6× | Report | 6× | Partille Arena, Partille Attendance: 600 Referees: Sá, Sá (POR) |
| 12 September 2021 16:00 | Kastamonu Bld. GSK | 25–31 | Odense Håndbold | Kastamonu Atatürk Sport Hall, Kastamonu Attendance: 1,200 Referees: Vujačić, Kažanegra (MNE) |
| 12 September 2021 16:00 | Radičević 9 | (11–15) | Housheer, Højlund 7 | Kastamonu Atatürk Sport Hall, Kastamonu Attendance: 1,200 Referees: Vujačić, Kažanegra (MNE) |
| 12 September 2021 16:00 | 1× 3× | Report | 3× | Kastamonu Atatürk Sport Hall, Kastamonu Attendance: 1,200 Referees: Vujačić, Kažanegra (MNE) |
| 18 September 2021 16:00 | Odense Håndbold | 21–27 | Metz Handball | Sydbank Arena Odense, Odense Attendance: 1,647 Referees: Lončar, Lončar (CRO) |
| 18 September 2021 16:00 | Housheer 9 | (13–15) | Nocandy 7 | Sydbank Arena Odense, Odense Attendance: 1,647 Referees: Lončar, Lončar (CRO) |
| 18 September 2021 16:00 | 3× | Report | 1× 3× | Sydbank Arena Odense, Odense Attendance: 1,647 Referees: Lončar, Lončar (CRO) |
| 18 September 2021 18:00 | RK Krim Mercator | 26–31 | Győri Audi ETO KC | Arena Stožice, Ljubljana Attendance: 542 Referees: Jurinović, Mrvica (CRO) |
| 18 September 2021 18:00 | Sercien-Ugolin 5 | (12–13) | Kristiansen, Ryu 7 | Arena Stožice, Ljubljana Attendance: 542 Referees: Jurinović, Mrvica (CRO) |
| 18 September 2021 18:00 | 2× 1× | Report | 2× 1× | Arena Stožice, Ljubljana Attendance: 542 Referees: Jurinović, Mrvica (CRO) |
| 18 September 2021 18:00 | Vipers Kristiansand | 34–25 | IK Sävehof | Aquarama Kristiansand, Kristiansand Attendance: 850 Referees: Geraets, Geraets (NED) |
| 18 September 2021 18:00 | Mørk 12 | (15–11) | Roberts 5 | Aquarama Kristiansand, Kristiansand Attendance: 850 Referees: Geraets, Geraets (NED) |
| 18 September 2021 18:00 | 1× 4× | Report | 1× 2× | Aquarama Kristiansand, Kristiansand Attendance: 850 Referees: Geraets, Geraets (NED) |
| 19 September 2021 14:00 | CSKA Moscow | 34–27 | Kastamonu Bld. GSK | Dynamo Sports Palace, Moscow Attendance: 415 Referees: Jovandić, Sekulić (SRB) |
| 19 September 2021 14:00 | Gros 10 | (16–15) | Radičević 8 | Dynamo Sports Palace, Moscow Attendance: 415 Referees: Jovandić, Sekulić (SRB) |
| 19 September 2021 14:00 | 1× 2× | Report | 4× | Dynamo Sports Palace, Moscow Attendance: 415 Referees: Jovandić, Sekulić (SRB) |
| 25 September 2021 16:00 | Kastamonu Bld. GSK | 23–24 | RK Krim Mercator | Merkez Spor Salonu, Kastamonu Attendance: 350 Referees: Năstase, Stancu (ROU) |
| 25 September 2021 16:00 | Kovářová, Radičević 5 | (9–12) | Krpež Šlezak 9 | Merkez Spor Salonu, Kastamonu Attendance: 350 Referees: Năstase, Stancu (ROU) |
| 25 September 2021 16:00 | 1× 5× | Report | 1× 2× | Merkez Spor Salonu, Kastamonu Attendance: 350 Referees: Năstase, Stancu (ROU) |
| 26 September 2021 16:00 | Győri Audi ETO KC | 32–22 | CSKA Moscow | Audi Aréna, Győr Attendance: 4,071 Referees: Álvarez, Bustamante (ESP) |
| 26 September 2021 16:00 | Oftedal 5 | (17–15) | Gros, Sabirova 6 | Audi Aréna, Győr Attendance: 4,071 Referees: Álvarez, Bustamante (ESP) |
| 26 September 2021 16:00 | 4× 1× | Report | 2× 3× | Audi Aréna, Győr Attendance: 4,071 Referees: Álvarez, Bustamante (ESP) |
| 26 September 2021 16:00 | Metz Handball | 23–18 | Vipers Kristiansand | Palais des Sports Jean Weille, Nancy Attendance: 2,765 Referees: Simone, Monitillo (ITA) |
| 26 September 2021 16:00 | Nocandy 5 | (14–9) | Mørk 5 | Palais des Sports Jean Weille, Nancy Attendance: 2,765 Referees: Simone, Monitillo (ITA) |
| 26 September 2021 16:00 | 5× | Report | 1× 5× | Palais des Sports Jean Weille, Nancy Attendance: 2,765 Referees: Simone, Monitillo (ITA) |
| 26 September 2021 16:00 | IK Sävehof | 31–37 | Odense Håndbold | Partille Arena, Partille Attendance: 600 Referees: Merz, Kuttler (GER) |
| 26 September 2021 16:00 | Roberts 10 | (16–19) | Rej 8 | Partille Arena, Partille Attendance: 600 Referees: Merz, Kuttler (GER) |
| 26 September 2021 16:00 | 2× 4× | Report | 1× 1× | Partille Arena, Partille Attendance: 600 Referees: Merz, Kuttler (GER) |
| 16 October 2021 18:00 | Vipers Kristiansand | 39–25 | Kastamonu Bld. GSK | Aquarama Kristiansand, Kristiansand Attendance: 1,350 Referees: Kijauskaitė, Žalienė (LTU) |
| 16 October 2021 18:00 | Mørk 8 | (20–11) | Akgün 6 | Aquarama Kristiansand, Kristiansand Attendance: 1,350 Referees: Kijauskaitė, Žalienė (LTU) |
| 16 October 2021 18:00 | 1× 4× | Report | 1× 6× 2× | Aquarama Kristiansand, Kristiansand Attendance: 1,350 Referees: Kijauskaitė, Žalienė (LTU) |
| 17 October 2021 14:00 | CSKA Moscow | 29–28 | IK Sävehof | Dynamo Sports Palace, Moscow Attendance: 550 Referees: Butskevich, Butskevich (BLR) |
| 17 October 2021 14:00 | Ilyina, Sabirova 6 | (14–11) | Roberts 8 | Dynamo Sports Palace, Moscow Attendance: 550 Referees: Butskevich, Butskevich (BLR) |
| 17 October 2021 14:00 | 1× 2× | Report | 1× 5× | Dynamo Sports Palace, Moscow Attendance: 550 Referees: Butskevich, Butskevich (BLR) |
| 17 October 2021 16:00 | RK Krim Mercator | 28–29 | Metz Handball | Arena Stožice, Ljubljana Attendance: 1,000 Referees: Alpaidze, Berezkina (RUS) |
| 17 October 2021 16:00 | Pineau 7 | (17–15) | Nocandy 8 | Arena Stožice, Ljubljana Attendance: 1,000 Referees: Alpaidze, Berezkina (RUS) |
| 17 October 2021 16:00 | 1× 5× | Report | 1× 6× | Arena Stožice, Ljubljana Attendance: 1,000 Referees: Alpaidze, Berezkina (RUS) |
| 17 October 2021 16:00 | Odense Håndbold | 26–31 | Győri Audi ETO KC | Phønix Tag Arena, Gudme Attendance: 1,556 Referees: Carmaux, Mursch (FRA) |
| 17 October 2021 16:00 | Housheer 7 | (11–16) | Ryu, Schatzl 6 | Phønix Tag Arena, Gudme Attendance: 1,556 Referees: Carmaux, Mursch (FRA) |
| 17 October 2021 16:00 | 1× 4× | Report | 1× 6× | Phønix Tag Arena, Gudme Attendance: 1,556 Referees: Carmaux, Mursch (FRA) |
| 23 October 2021 18:00 | Vipers Kristiansand | 24–27 | CSKA Moscow | Aquarama Kristiansand, Kristiansand Attendance: 1,329 Referees: Sá, Sá (POR) |
| 23 October 2021 18:00 | Mørk 9 | (11–11) | Mikhaylichenko 10 | Aquarama Kristiansand, Kristiansand Attendance: 1,329 Referees: Sá, Sá (POR) |
| 23 October 2021 18:00 | 2× 4× 1× | Report | 2× 3× 1× | Aquarama Kristiansand, Kristiansand Attendance: 1,329 Referees: Sá, Sá (POR) |
| 23 October 2021 18:00 | Metz Handball | 29–33 | Győri Audi ETO KC | Arènes de Metz, Metz Attendance: 4,051 Referees: Năstase, Stancu (ROU) |
| 23 October 2021 18:00 | De Paula 7 | (15–16) | Schatzl 5 | Arènes de Metz, Metz Attendance: 4,051 Referees: Năstase, Stancu (ROU) |
| 23 October 2021 18:00 | 2× 2× | Report | 1× 1× | Arènes de Metz, Metz Attendance: 4,051 Referees: Năstase, Stancu (ROU) |
| 24 October 2021 16:00 | Odense Håndbold | 26–24 | RK Krim Mercator | Phønix Tag Arena, Gudme Attendance: 1,217 Referees: Sekulić, Jovandić (SRB) |
| 24 October 2021 16:00 | Van Wetering 5 | (13–10) | Stanko 7 | Phønix Tag Arena, Gudme Attendance: 1,217 Referees: Sekulić, Jovandić (SRB) |
| 24 October 2021 16:00 | 1× 3× | Report | 4× | Phønix Tag Arena, Gudme Attendance: 1,217 Referees: Sekulić, Jovandić (SRB) |
| 24 October 2021 16:00 | IK Sävehof | 28–26 | Kastamonu Bld. GSK | Partille Arena, Partille Attendance: 850 Referees: Lončar, Lončar (CRO) |
| 24 October 2021 16:00 | Mortensen 6 | (11–17) | Demirçelen, Kovářová 5 | Partille Arena, Partille Attendance: 850 Referees: Lončar, Lončar (CRO) |
| 24 October 2021 16:00 | 1× 3× | Report | 1× 1× | Partille Arena, Partille Attendance: 850 Referees: Lončar, Lončar (CRO) |
| 30 October 2021 16:00 | Győri Audi ETO KC | 41–19 | IK Sävehof | Audi Aréna, Győr Attendance: 3,945 Referees: Jović, Arnautović (BIH) |
| 30 October 2021 16:00 | Blohm 7 | (20–9) | Roberts 5 | Audi Aréna, Győr Attendance: 3,945 Referees: Jović, Arnautović (BIH) |
| 30 October 2021 16:00 | 1× | Report | 2× | Audi Aréna, Győr Attendance: 3,945 Referees: Jović, Arnautović (BIH) |
| 30 October 2021 18:00 | RK Krim Mercator | 26–27 | Vipers Kristiansand | Arena Stožice, Ljubljana Attendance: 500 Referees: Barysas, Petrušis (LTU) |
| 30 October 2021 18:00 | Stanko 6 | (16–10) | Mørk 11 | Arena Stožice, Ljubljana Attendance: 500 Referees: Barysas, Petrušis (LTU) |
| 30 October 2021 18:00 | 1× 5× | Report | 1× 3× | Arena Stožice, Ljubljana Attendance: 500 Referees: Barysas, Petrušis (LTU) |
| 31 October 2021 16:00 | CSKA Moscow | 21–28 | Odense Håndbold | Dynamo Sports Palace, Moscow Attendance: 0 Referees: Andorka, Hucker (HUN) |
| 31 October 2021 16:00 | Skorobogatchenko 5 | (13–14) | Rej 8 | Dynamo Sports Palace, Moscow Attendance: 0 Referees: Andorka, Hucker (HUN) |
| 31 October 2021 16:00 | 1× 3× | Report | 1× 4× | Dynamo Sports Palace, Moscow Attendance: 0 Referees: Andorka, Hucker (HUN) |
| 31 October 2021 16:00 | Kastamonu Bld. GSK | 20–30 | Metz Handball | Kastamonu Atatürk Sport Hall, Kastamonu Attendance: 1,000 Referees: Antić, Jakovljević (SRB) |
| 31 October 2021 16:00 | Radičević 5 | (9–13) | N'Gouan 6 | Kastamonu Atatürk Sport Hall, Kastamonu Attendance: 1,000 Referees: Antić, Jakovljević (SRB) |
| 31 October 2021 16:00 | 1× 4× | Report | 2× 3× | Kastamonu Atatürk Sport Hall, Kastamonu Attendance: 1,000 Referees: Antić, Jakovljević (SRB) |
| 13 November 2021 18:00 | Győri Audi ETO KC | 37–20 | Kastamonu Bld. GSK | Audi Aréna, Győr Attendance: 3,100 Referees: Duplii, Pobedrina (UKR) |
| 13 November 2021 18:00 | Nze Minko 6 | (19–9) | Radičević 11 | Audi Aréna, Győr Attendance: 3,100 Referees: Duplii, Pobedrina (UKR) |
| 13 November 2021 18:00 | 1× 2× | Report | 1× 3× | Audi Aréna, Győr Attendance: 3,100 Referees: Duplii, Pobedrina (UKR) |
| 14 November 2021 14:00 | CSKA Moscow | 21–21 | RK Krim Mercator | Dynamo Sports Palace, Moscow Attendance: 370 Referees: Konjičanin, Konjičanin (BIH) |
| 14 November 2021 14:00 | Ristovska 5 | (11–12) | Stanko 7 | Dynamo Sports Palace, Moscow Attendance: 370 Referees: Konjičanin, Konjičanin (BIH) |
| 14 November 2021 14:00 | 1× 2× | Report | 2× 2× | Dynamo Sports Palace, Moscow Attendance: 370 Referees: Konjičanin, Konjičanin (BIH) |
| 14 November 2021 16:00 | Odense Håndbold | 27–32 | Vipers Kristiansand | Sydbank Arena Odense, Odense Attendance: 2,117 Referees: Vešović, Mitrović (MNE) |
| 14 November 2021 16:00 | Rej 7 | (15–17) | Knedlíková, Mørk 8 | Sydbank Arena Odense, Odense Attendance: 2,117 Referees: Vešović, Mitrović (MNE) |
| 14 November 2021 16:00 | 2× 3× | Report | 2× 4× | Sydbank Arena Odense, Odense Attendance: 2,117 Referees: Vešović, Mitrović (MNE) |
| 14 November 2021 16:00 | IK Sävehof | 28–31 | Metz Handball | Partille Arena, Partille Attendance: 1,522 Referees: Vranes, Wenninger (AUT) |
| 14 November 2021 16:00 | Roberts 11 | (12–15) | N'Gouan 8 | Partille Arena, Partille Attendance: 1,522 Referees: Vranes, Wenninger (AUT) |
| 14 November 2021 16:00 | 2× 4× 1× | Report | 3× | Partille Arena, Partille Attendance: 1,522 Referees: Vranes, Wenninger (AUT) |
| 17 November 2021 20:45 | Metz Handball | 24–32 | CSKA Moscow | Palais des Sports Jean Weille, Nancy Attendance: 2,754 Referees: Merz, Kuttler (GER) |
| 17 November 2021 20:45 | Mičijević 5 | (12–15) | Gros 12 | Palais des Sports Jean Weille, Nancy Attendance: 2,754 Referees: Merz, Kuttler (GER) |
| 17 November 2021 20:45 | 2× 1× | Report | 2× 2× | Palais des Sports Jean Weille, Nancy Attendance: 2,754 Referees: Merz, Kuttler (GER) |
| 20 November 2021 16:00 | RK Krim Mercator | 24–21 | CSKA Moscow | Arena Stožice, Ljubljana Attendance: 380 Referees: Lončar, Lončar (CRO) |
| 20 November 2021 16:00 | Krpež Šlezak 7 | (11–10) | Gros 7 | Arena Stožice, Ljubljana Attendance: 380 Referees: Lončar, Lončar (CRO) |
| 20 November 2021 16:00 | 3× 1× | Report | 2× 4× | Arena Stožice, Ljubljana Attendance: 380 Referees: Lončar, Lončar (CRO) |
| 20 November 2021 18:00 | Vipers Kristiansand | 31–27 | Odense Håndbold | Aquarama Kristiansand, Kristiansand Attendance: 1,416 Referees: Năstase, Stancu (ROU) |
| 20 November 2021 18:00 | Mørk 7 | (17–16) | Housheer, Højlund 5 | Aquarama Kristiansand, Kristiansand Attendance: 1,416 Referees: Năstase, Stancu (ROU) |
| 20 November 2021 18:00 | 3× | Report | 1× 3× 1× | Aquarama Kristiansand, Kristiansand Attendance: 1,416 Referees: Năstase, Stancu (ROU) |
| 20 November 2021 18:00 | Kastamonu Bld. GSK | 22–38 | Győri Audi ETO KC | Kastamonu Atatürk Sport Hall, Kastamonu Attendance: 2,627 Referees: Ilieva, Karbeska (MKD) |
| 20 November 2021 18:00 | Kovářová, Radičević 4 | (9–19) | Pintea 6 | Kastamonu Atatürk Sport Hall, Kastamonu Attendance: 2,627 Referees: Ilieva, Karbeska (MKD) |
| 20 November 2021 18:00 | 2× | Report | 2× 1× | Kastamonu Atatürk Sport Hall, Kastamonu Attendance: 2,627 Referees: Ilieva, Karbeska (MKD) |
| 21 November 2021 16:00 | Metz Handball | 35–21 | IK Sävehof | Arènes de Metz, Metz Attendance: 2,723 Referees: Christiansen, Hansen (DEN) |
| 21 November 2021 16:00 | Horacek, Nocandy 6 | (19–15) | Blomst 7 | Arènes de Metz, Metz Attendance: 2,723 Referees: Christiansen, Hansen (DEN) |
| 21 November 2021 16:00 | 2× 4× | Report | 2× 3× 1× | Arènes de Metz, Metz Attendance: 2,723 Referees: Christiansen, Hansen (DEN) |
| 9 January 2022 16:00 | Odense Håndbold | 27–27 | CSKA Moscow | Sydbank Arena Odense, Odense Attendance: 0 Referees: Budzák, Záhradník (SVK) |
| 9 January 2022 16:00 | Aardahl 6 | (12–12) | Gros 6 | Sydbank Arena Odense, Odense Attendance: 0 Referees: Budzák, Záhradník (SVK) |
| 9 January 2022 16:00 | 3× | Report | 2× 4× | Sydbank Arena Odense, Odense Attendance: 0 Referees: Budzák, Záhradník (SVK) |
| 9 January 2022 16:00 | IK Sävehof | 23–42 | Vipers Kristiansand | Partille Arena, Partille Attendance: 1,620 Referees: Christidi, Papamattheou (GRE) |
| 9 January 2022 16:00 | Rosell 7 | (15–21) | Valle Dahl 8 | Partille Arena, Partille Attendance: 1,620 Referees: Christidi, Papamattheou (GRE) |
| 9 January 2022 16:00 | 3× | Report | 2× | Partille Arena, Partille Attendance: 1,620 Referees: Christidi, Papamattheou (GRE) |
| 15 January 2022 16:00 | Győri Audi ETO KC | 39–30 | Metz Handball | Audi Aréna, Győr Referees: Metalari, Nikolovski (MKD) |
| 15 January 2022 16:00 | Kristiansen 10 | (20–13) | Horacek 8 | Audi Aréna, Győr Referees: Metalari, Nikolovski (MKD) |
| 15 January 2022 16:00 | 3× | Report | 5× | Audi Aréna, Győr Referees: Metalari, Nikolovski (MKD) |
| 16 January 2022 16:00 | CSKA Moscow | 28–32 | Vipers Kristiansand | Dynamo Sports Palace, Moscow Attendance: 900 Referees: Vujačić, Kažanegra (MNE) |
| 16 January 2022 16:00 | Gros 9 | (13–16) | Jeřábková 8 | Dynamo Sports Palace, Moscow Attendance: 900 Referees: Vujačić, Kažanegra (MNE) |
| 16 January 2022 16:00 | 1× 1× | Report | 2× 2× | Dynamo Sports Palace, Moscow Attendance: 900 Referees: Vujačić, Kažanegra (MNE) |
| 16 January 2022 16:00 | RK Krim Mercator | 19–24 | Odense Håndbold | Arena Stožice, Ljubljana Attendance: 350 Referees: Antić, Jakovljević (SRB) |
| 16 January 2022 16:00 | Klemenčič, Posavec 3 | (5–15) | Van Wetering 4 | Arena Stožice, Ljubljana Attendance: 350 Referees: Antić, Jakovljević (SRB) |
| 16 January 2022 16:00 | 1× 3× | Report | 2× 2× | Arena Stožice, Ljubljana Attendance: 350 Referees: Antić, Jakovljević (SRB) |
| 19 January 2022 18:45 | Metz Handball | 33–25 | Kastamonu Bld. GSK | Arènes de Metz, Metz Attendance: 1,752 Referees: Martins, Martins (POR) |
| 19 January 2022 18:45 | Horacek 6 | (17–10) | Radičević 8 | Arènes de Metz, Metz Attendance: 1,752 Referees: Martins, Martins (POR) |
| 19 January 2022 18:45 | 4× | Report | 5× | Arènes de Metz, Metz Attendance: 1,752 Referees: Martins, Martins (POR) |
| 19 January 2022 18:45 | Győri Audi ETO KC | 40–27 | RK Krim Mercator | Audi Aréna, Győr Attendance: 2,547 Referees: Vranes, Wenninger (AUT) |
| 19 January 2022 18:45 | Hansen, Pintea 8 | (22–14) | Pineau, Varagić 5 | Audi Aréna, Győr Attendance: 2,547 Referees: Vranes, Wenninger (AUT) |
| 19 January 2022 18:45 | 1× 2× | Report | 3× | Audi Aréna, Győr Attendance: 2,547 Referees: Vranes, Wenninger (AUT) |
| 22 January 2022 18:00 | Kastamonu Bld. GSK | 24–35 | Vipers Kristiansand | Kastamonu Atatürk Sport Hall, Kastamonu Attendance: 2,700 Referees: Merz, Kuttler (GER) |
| 22 January 2022 18:00 | Radičević, Yılmaz 5 | (12–18) | Debelić 7 | Kastamonu Atatürk Sport Hall, Kastamonu Attendance: 2,700 Referees: Merz, Kuttler (GER) |
| 22 January 2022 18:00 | 3× | Report | 1× 1× | Kastamonu Atatürk Sport Hall, Kastamonu Attendance: 2,700 Referees: Merz, Kuttler (GER) |
| 23 January 2022 14:00 | IK Sävehof | 23–32 | CSKA Moscow | Partille Arena, Partille Referees: Geraets, Geraets (NED) |
| 23 January 2022 14:00 | Roberts 6 | (10–14) | Gros 7 | Partille Arena, Partille Referees: Geraets, Geraets (NED) |
| 23 January 2022 14:00 | 1× 2× | Report | 1× 2× | Partille Arena, Partille Referees: Geraets, Geraets (NED) |
| 23 January 2022 16:00 | Győri Audi ETO KC | 27–26 | Odense Håndbold | Audi Aréna, Győr Attendance: 3,900 Referees: Lončar, Lončar (CRO) |
| 23 January 2022 16:00 | Nze Minko, Bredal Oftedal 5 | (12–13) | Højlund 9 | Audi Aréna, Győr Attendance: 3,900 Referees: Lončar, Lončar (CRO) |
| 23 January 2022 16:00 | 3× | Report | 1× 5× | Audi Aréna, Győr Attendance: 3,900 Referees: Lončar, Lončar (CRO) |
| 29 January 2022 12:00 | Kastamonu Bld. GSK | 26–29 | IK Sävehof | Kastamonu Atatürk Sport Hall, Kastamonu Attendance: 1,500 Referees: Covalciuc, Covalciuc (MDA) |
| 29 January 2022 12:00 | Radičević 6 | (14–16) | Tolstrup Petersen 7 | Kastamonu Atatürk Sport Hall, Kastamonu Attendance: 1,500 Referees: Covalciuc, Covalciuc (MDA) |
| 29 January 2022 12:00 | 2× 1× | Report | 1× 3× | Kastamonu Atatürk Sport Hall, Kastamonu Attendance: 1,500 Referees: Covalciuc, Covalciuc (MDA) |
| 5 February 2022 16:00 | RK Krim Mercator | 36–28 | Kastamonu Bld. GSK | Arena Stožice, Ljubljana Attendance: 550 Referees: Vitaku, Vitaku (KOS) |
| 5 February 2022 16:00 | Krpež Šlezak 13 | (18–10) | Radičević 7 | Arena Stožice, Ljubljana Attendance: 550 Referees: Vitaku, Vitaku (KOS) |
| 5 February 2022 16:00 | 1× 2× | Report | 1× 3× | Arena Stožice, Ljubljana Attendance: 550 Referees: Vitaku, Vitaku (KOS) |
| 5 February 2022 18:00 | Vipers Kristiansand | 25–31 | Metz Handball | Aquarama Kristiansand, Kristiansand Attendance: 1,231 Referees: Weijmans, Wolbertus (NED) |
| 5 February 2022 18:00 | Debelić 7 | (13–17) | three players 6 | Aquarama Kristiansand, Kristiansand Attendance: 1,231 Referees: Weijmans, Wolbertus (NED) |
| 5 February 2022 18:00 | 2× | Report | 1× 6× 1× | Aquarama Kristiansand, Kristiansand Attendance: 1,231 Referees: Weijmans, Wolbertus (NED) |
| 6 February 2022 16:00 | Odense Håndbold | 37–24 | IK Sävehof | Sydbank Arena Odense, Odense Attendance: 1,702 Referees: Barysas, Petrusis (LTU) |
| 6 February 2022 16:00 | Abbingh 8 | (16–13) | Roberts 6 | Sydbank Arena Odense, Odense Attendance: 1,702 Referees: Barysas, Petrusis (LTU) |
| 6 February 2022 16:00 | 3× | Report | 1× 4× | Sydbank Arena Odense, Odense Attendance: 1,702 Referees: Barysas, Petrusis (LTU) |
| 6 February 2022 16:00 | CSKA Moscow | 23–27 | Győri Audi ETO KC | Dynamo Sports Palace, Moscow Attendance: 1,100 Referees: Pandžić, Mošorinski (SRB) |
| 6 February 2022 16:00 | Ilyina 8 | (13–15) | Ryu 7 | Dynamo Sports Palace, Moscow Attendance: 1,100 Referees: Pandžić, Mošorinski (SRB) |
| 6 February 2022 16:00 | 2× 1× | Report | 1× 3× | Dynamo Sports Palace, Moscow Attendance: 1,100 Referees: Pandžić, Mošorinski (SRB) |
| 9 February 2022 18:45 | Metz Handball | 27–27 | RK Krim Mercator | Arènes de Metz, Metz Attendance: 3,152 Referees: Hannes, Hannes (GER) |
| 9 February 2022 18:45 | Burgaard 5 | (17–15) | Krpež Šlezak, Stanko 5 | Arènes de Metz, Metz Attendance: 3,152 Referees: Hannes, Hannes (GER) |
| 9 February 2022 18:45 | 1× 2× | Report | 1× 2× | Arènes de Metz, Metz Attendance: 3,152 Referees: Hannes, Hannes (GER) |
| 12 February 2022 16:00 | Vipers Kristiansand | 37–20 | RK Krim Mercator | Aquarama Kristiansand, Kristiansand Attendance: 1,036 Referees: Panayides, Andreou (CYP) |
| 12 February 2022 16:00 | Valle Dahl 7 | (17–9) | Krpež Šlezak 7 | Aquarama Kristiansand, Kristiansand Attendance: 1,036 Referees: Panayides, Andreou (CYP) |
| 12 February 2022 16:00 | 1× 3× | Report | 4× | Aquarama Kristiansand, Kristiansand Attendance: 1,036 Referees: Panayides, Andreou (CYP) |
| 12 February 2022 18:00 | Metz Handball | 38–31 | Odense Håndbold | Arènes de Metz, Metz Attendance: 3,650 Referees: Sá, Sá (POR) |
| 12 February 2022 18:00 | Mičijević 10 | (19–17) | Abbingh 7 | Arènes de Metz, Metz Attendance: 3,650 Referees: Sá, Sá (POR) |
| 12 February 2022 18:00 | 1× 6× | Report | 1× 3× 1× | Arènes de Metz, Metz Attendance: 3,650 Referees: Sá, Sá (POR) |
| 13 February 2022 14:00 | Kastamonu Bld. GSK | 29–31 | CSKA Moscow | Kastamonu Atatürk Sport Hall, Kastamonu Attendance: 1,800 Referees: Jović, Arnautović (BIH) |
| 13 February 2022 14:00 | Radičević 9 | (15–18) | Heindahl, Mikhaylichenko 6 | Kastamonu Atatürk Sport Hall, Kastamonu Attendance: 1,800 Referees: Jović, Arnautović (BIH) |
| 13 February 2022 14:00 | 2× | Report | 2× 1× | Kastamonu Atatürk Sport Hall, Kastamonu Attendance: 1,800 Referees: Jović, Arnautović (BIH) |
| 13 February 2022 16:00 | IK Sävehof | 25–31 | Győri Audi ETO KC | Partille Arena, Partille Attendance: 1,275 Referees: Kijauskaitė, Žalienė (LTU) |
| 13 February 2022 16:00 | Roberts 7 | (12–15) | Hansen 6 | Partille Arena, Partille Attendance: 1,275 Referees: Kijauskaitė, Žalienė (LTU) |
| 13 February 2022 16:00 | 2× 2× | Report | 1× 1× | Partille Arena, Partille Attendance: 1,275 Referees: Kijauskaitė, Žalienė (LTU) |
| 19 February 2022 18:00 | Vipers Kristiansand | 30–29 | Győri Audi ETO KC | Aquarama Kristiansand, Kristiansand Attendance: 1,900 Referees: Budzák, Záhradník (SVK) |
| 19 February 2022 18:00 | Gulldén, Jeřábková 6 | (16–13) | Hansen 6 | Aquarama Kristiansand, Kristiansand Attendance: 1,900 Referees: Budzák, Záhradník (SVK) |
| 19 February 2022 18:00 | 1× 1× | Report | 3× | Aquarama Kristiansand, Kristiansand Attendance: 1,900 Referees: Budzák, Záhradník (SVK) |
| 20 February 2022 14:00 | RK Krim Mercator | 32–18 | IK Sävehof | Arena Stožice, Ljubljana Attendance: 1,100 Referees: Alpaidze, Berezkina (RUS) |
| 20 February 2022 14:00 | Stanko 8 | (12–9) | Nilsson Åström 4 | Arena Stožice, Ljubljana Attendance: 1,100 Referees: Alpaidze, Berezkina (RUS) |
| 20 February 2022 14:00 | 1× 3× | Report | 1× | Arena Stožice, Ljubljana Attendance: 1,100 Referees: Alpaidze, Berezkina (RUS) |
| 20 February 2022 16:00 | CSKA Moscow | 27–26 | Metz Handball | Dynamo Sports Palace, Moscow Attendance: 940 Referees: Covalciuc, Covalciuc (MDA) |
| 20 February 2022 16:00 | Gros 7 | (12–15) | Horacek 5 | Dynamo Sports Palace, Moscow Attendance: 940 Referees: Covalciuc, Covalciuc (MDA) |
| 20 February 2022 16:00 | 1× 2× | Report | 5× | Dynamo Sports Palace, Moscow Attendance: 940 Referees: Covalciuc, Covalciuc (MDA) |
| 20 February 2022 16:00 | Odense Håndbold | 37–29 | Kastamonu Bld. GSK | Sydbank Arena Odense, Odense Attendance: 1,512 Referees: Lidacka, Lesiak (POL) |
| 20 February 2022 16:00 | Aardahl 8 | (18–13) | Radičević 6 | Sydbank Arena Odense, Odense Attendance: 1,512 Referees: Lidacka, Lesiak (POL) |
| 20 February 2022 16:00 | 1× 1× | Report | 4× | Sydbank Arena Odense, Odense Attendance: 1,512 Referees: Lidacka, Lesiak (POL) |