OpenLLM-France/wikimedia huggingface dataset:
# Orientations of Proteins in Membranes database

Orientations of Proteins in Membranes (OPM) database provides spatial positions of membrane protein structures with respect to the lipid bilayer. Positions of the proteins are calculated using an implicit solvation model of the lipid bilayer. The results of calculations were verified against experimental studies of spatial arrangement of transmembrane and peripheral proteins in membranes.
Proteins structures are taken from the Protein Data Bank. OPM also provides structural classification of membrane-associated proteins into families and superfamilies, membrane topology, quaternary structure of proteins in membrane-bound state, and the type of a destination membrane for each protein. The coordinate files with calculated membrane boundaries are downloadable. The site allows visualization of protein structures with membrane boundary planes through Jmol.
The database was widely used in experimental and theoretical studies of membrane-associated proteins. However, structures of many membrane-associated proteins are not included in the database if their spatial arrangement in membrane can not be computationally predicted from the three-dimensional structure. This is the case when all membrane-anchoring parts of the proteins (amphiphilic alpha helices, exposed nonpolar residues, or lipidated amino acid residues) are missing in the experimental structures. The database also does not include lower resolution structures with only main chain atoms provided by the Protein Data Bank. The calculated spatial arrangements of the lower resolution protein structures in the lipid bilayer can be found in other resources, such as PDBTM.
# Oreodera turnbowi

Oreodera turnbowi is a species of long-horned beetle in the family Cerambycidae. It is found in Mexico.
# Ornithological Society of the Middle East

The Ornithological Society of the Middle East (OSME) is a British-based ornithological and birdwatching club for people interested in the birds of the Middle East, the Caucasus and Central Asia. It was established in April 1978 as a successor organisation to the Ornithological Society of Turkey, and in 2001 was expanded to cover central Asia and the Caucasus.
Its aims are, with regard to its area of interest, to collect, collate and publish ornithological data, encourage an interest in and conservation of the birds of the region, and to assist regional environmental and conservation organisations and natural history societies with ornithological studies and activities.

## Publications

OSME publishes the journal Sandgrouse.

## Member countries

The following territories of the Middle East are where OSME are active:
* Bahrain
* Cyprus
* Djibouti
* Egypt
* Iran
* Iraq
* Israel
* Jordan
* Kuwait
* Lebanon
* Oman
* Palestine
* Qatar
* Saudi Arabia
* Turkey
* United Arab Emirates
* Yemen
# Pryser

Pryser is a Norwegian surname. Notable people with the surname include:
* Thoralf Pryser (1885–1970), Norwegian journalist and newspaper editor
* Tore Pryser (born 1945), Norwegian historian
# Midwest Questar Sport

The Midwest Questar Sport is an American ultralight aircraft that was designed and produced by Midwest Engineering of Overland Park, Kansas. When it was available the aircraft was supplied in the form of plans for amateur construction, but the plans were withdrawn on 29 June 2000.

## Design and development

The Questar Sport was designed to comply with the US FAR 103 Ultralight Vehicles rules, including the category's maximum empty weight of 254 lb (115 kg). The aircraft has a standard empty weight of 160 lb (73 kg).
The aircraft features a strut-braced high-wing, a single-seat open cockpit without a windshield, fixed conventional landing gear without wheel pants and a single engine in tractor configuration.
The Questar Sport is made from bolted-together 6061-T6 aluminum tubing, with its flying surfaces covered in doped aircraft fabric. Its 33.25 ft (10.1 m) span wing has a wing area of 165.0 sq ft (15.33 m$^2$), is supported by "V" struts and can be folded in ten minutes for ground transport or storage. The acceptable power range is 30 to 40 hp (22 to 30 kW) and the standard engines used are small 30 hp (22 kW) two-stroke powerplants.
The aircraft has a typical empty weight of 160 lb (73 kg) and a gross weight of 400 lb (180 kg), giving a useful load of 240 lb (110 kg). With full fuel of 3 U.S. gallons (11 L; 2.5 imp gal) the payload for the pilot and baggage is 222 lb (101 kg).
The standard day, sea level, no wind, take off distance with a 30 hp (22 kW) engine is 120 ft (37 m) and the landing roll is 80 ft (24 m).
The manufacturer estimated the construction time from the supplied plans as 80 hours.

## Operational history

By 1998 the company reported that 120 sets of plans had been sold and that 30 aircraft were completed and flying.

## Specifications (Questar Sport)

Data from AeroCrafter
General characteristics
* Crew: one
* Length: 17.50 ft (5.33 m)
* Wingspan: 33.25 ft (10.13 m)
* Wing area: 165.0 sq ft (15.33 m$^2$)
* Empty weight: 160 lb (73 kg)
* Gross weight: 400 lb (181 kg)
* Fuel capacity: 3 U.S. gallons (11 L; 2.5 imp gal)
* Powerplant: 1 × two-stroke aircraft engine, 30 hp (22 kW)
* Propellers: 2-bladed wooden
Performance
* Maximum speed: 48 mph (77 km/h, 42 kn)
* Cruise speed: 38 mph (61 km/h, 33 kn)
* Stall speed: 20 mph (32 km/h, 17 kn)
* Range: 60 mi (97 km, 52 nmi)
* Service ceiling: 10,000 ft (3,000 m)
* Rate of climb: 350 ft/min (1.8 m/s)
* Wing loading: 2.4 lb/sq ft (12 kg/m$^2$)
# Sonja Kešerac

Sonja Kešerac (born 20 February 1985 in Osijek) is a Croatian rower. Since 2009, Kešerac has competed in coxless pairs with Maja Anić.
# Suicide tree

Suicide tree may refer to at least two different plant species:
* Cerbera odollam (native to India) so called because it is toxic
* Tachigali versicolor (native to Central America) so called because it reproduces once before dying
# New York–New Jersey League

The New York–New Jersey League was a class D level minor league baseball league that played in the 1913 season. With the New York State League and International League among others occupying the territory, the 6–team league had no large cities involved. The next year the circuit was renamed the Atlantic League.

## Cities represented

* Danbury, CT: Danbury Hatters 1913
* Kingston, NY: Kingston Colonials 1913
* Long Branch, NJ: Long Branch Cubans 1913
* Middletown, NY: Middletown Middies 1913
* Newburgh, NY: Newburgh Dutchmen 1913
* Poughkeepsie, NY: Poughkeepsie Honey Bugs 1913

## Standings and statistics
### 1913 New York–New Jersey League

| Team standings | W | L | PCT | GB | Managers |
| Long Branch Cubans | 65 | 29 | .691 | – | Ricardo Henriquez |
| Poughkeepsie Honey Bugs | 48 | 49 | .495 | 18.5 | Eugene Ressique |
| Kingston Colonials | 45 | 46 | .494 | 18.5 | Walter Bennett |
| Middletown Middies | 42 | 51 | .452 | 22.5 | Jack Lawler |
| Danbury Hatters | 43 | 55 | .439 | 24.0 | Ernest Landgraf |
| Newburgh Dutchmen | 41 | 54 | .432 | 24.5 | Archie Marshall |
Playoffs: None
Player statistics :
| Player | Team | Stat | Tot | Player | Team | Stat | Tot |
| Frank Ely | Middletown | BA | .385 | Dolf Luque | Long Branch | W | 22 |
| Eugene Ressique | Poughkeepsie | Runs | 101 | Dolf Luque | Long Branch | Pct | .815; 22–5 |
| Juan Viola | Long Branch | Hits | 131 | Frank Ely | Middletown | HR | 7 |
| Edward Harrison | Newburgh | HR | 7 |

## Sources

* The Encyclopedia of Minor League Baseball: Second Edition.
# Michael J. Malik Sr.

Michael J. Malik Sr. (born February 1954) is a developer and entrepreneur from Detroit, Michigan who resides in Birmingham, Michigan. Currently his net worth is $750,000,000.
Since the early 1990s he and his partner Marian Ilitch have been catalysts for legalization of gambling and development of gambling halls from coast to coast and in Hawaii with mixed results. Among them: casinos for Michigan's Little River Band of Ottawa Indians in Manistee; and the Bay Mills Indian Community in Brimley and a proposed off-reservation casino in Port Huron; several failed attempts to legalize gambling in the State of Hawaii and develop casinos on Waikīkī Beach; a planned casino resort on Long Island, New York in the Town of Southampton (often referred to as The Hamptons) as "Gateway Casino Resorts, LLC" partnered with the Shinnecock Indians; and as Barwest, LLC, partners with the Big Lagoon Rancheria Indians and the Los Coyotes Band of Cahuilla and Cupeño Mission Indians to develop proposed dual off-reservation casinos in Barstow, California.
Malik is a hunter paid a $14,995 fine in 2008 for illegally shooting a large bull elk on an auction tag for which he paid $135,000.

## Detroit casino development

As a partner with NAG, Malik directed a ballot effort to bring casino gambling to Detroit, Michigan. In 1996, NAG teamed with Atwater Entertainment to support the passage of a Michigan statewide proposal facilitating the development of three commercial casinos in Detroit. Following passage of the proposal, Malik worked with state elected officials to negotiate and implement the regulatory oversight framework for the Detroit casinos.
Malik was a partner in the casino group Detroit Entertainment, which included Marina Ilitch and more than 130 local partners. Detroit Entertainment selected Mandalay Bay Group as casino operator, and Malik worked with them on the development of the casino project now called MotorCity Casino. His efforts have resulted in an entertainment industry in Detroit that today exceeds $1.3 billion per year.

## Native American gaming

Malik helped develop a casino for the Little River Band of Ottawa Indians in Manistee in northwest Michigan. He was responsible for site selection and land acquisition, construction firm selection, assistance in obtaining a gaming compact, and establishing casino operations. Today the Little River Casino is the third most profitable Indian owned and operated casino of the 18 located in Michigan.
Malik also assisted in the development of two casinos, a hotel and a golf course for the Bay Mills Indian Tribe in Brimley, Michigan. He assisted the tribe with the legislative approval process for obtaining the first gaming compact in Michigan. Malik is currently working with the Bay Mills Tribe to develop a casino in Port Huron, Michigan.
Malik is managing partner in the casino development group BarWest L.L.C., and is working with the Los Coyotes Band from San Diego County, California to construct and operate a world-class casino complex in Barstow, California.
# Members of the Western Australian Legislative Council, 1924–1926

This is a list of members of the Western Australian Legislative Council from 22 May, 1924 to 21 May, 1926. The chamber had 30 seats made up of ten provinces each electing three members, on a system of rotation whereby one-third of the members would retire at each biennial election. In the previous term, the Country Party split into rival Ministerial (MCP) and Executive (ECP) factions. The Executive faction, loyal to the Primary Producers' Association, prevailed and by 1925 the Ministerial faction had merged with the remnants of the National Labor Party into the Nationalist Party.
| Name | Party | Province | Term expires | Years in office |
| Charles Baxter | Country | East | 1926 | 1914–1950 |
| John Reid Brown | Labor | North-East | 1930 | 1924–1930 |
| Alfred Burvill | Country | South-East | 1928 | 1922–1928 |
| James Cornell | National Labor / Nationalist | South | 1930 | 1912–1946 |
| Jabez Dodd | National Labor/ Nationalist | South | 1928 | 1910–1928 |
| John Drew | Labor | Central | 1930 | 1900–1918; 1924–1947 |
| Joseph Duffell | Nationalist | Metropolitan-Suburban | 1926 | 1914–1926 |
| John Ewing | Nationalist | South-West | 1930 | 1916–1933 |
| William Glasheen | Country | South-East | 1926 | 1925–1932 |
| Edmund Gray | Labor | West | 1926 | 1923–1952 |
| James Greig | Country | South-East | 1926 | 1916–1925 |
| Vernon Hamersley | Country | East | 1928 | 1904–1946 |
| Edgar Harris | Nationalist | North-East | 1926 | 1920–1934 |
| James Hickey | Labor | Central | 1928 | 1916–1928 |
| Joseph Holmes | Independent | North | 1926 | 1914–1942 |
| John Kirwan | Independent | South | 1926 | 1908–1946 |
| William Kitson | Labor | West | 1930 | 1924–1947 |
| Arthur Lovekin | Nationalist | Metropolitan | 1930 | 1919–1931 |
| James Macfarlane | Nationalist | Metropolitan | 1928 | 1922–1928; 1930–1942 |
| George Miles | Independent | North | 1930 | 1916–1950 |
| Thomas Moore | Labor | Central | 1926 | 1920–1926; 1932–1946 |
| John Nicholson | Nationalist | Metropolitan | 1926 | 1918–1941 |
| George Potter | Nationalist | West | 1928 | 1922–1928 |
| Edwin Rose | Nationalist | South-West | 1928 | 1916–1934 |
| Athelstan Saw | Nationalist | Metropolitan-Suburban | 1928 | 1915–1929 |
| Harold Seddon | Nationalist | North-East | 1928 | 1922–1954 |
| Henry Stephenson | Nationalist | Metropolitan-Suburban | 1930 | 1924–1930 |
| Hector Stewart | Country | South-East | 1930 | 1917–1931 |
| Francis Willmott | Country | South-West | 1926 | 1921–1926 |
| Sir Edward Wittenoom | Nationalist | North | 1928 | 1883–1884; 1885–1886; 1894–1898; 1902–1906; 1910–1934 |
| Herbert Yelland | MCP/Nationalist | East | 1930 | 1924–1936 |
# London Buses route 97

London Buses route 97 is a Transport for London contracted bus route in London, England. Running between Chingford station and Stratford City bus station, it is operated by Stagecoach London.

## History

On 31 January 1981, Route 97 was introduced to replace the northern leg of Route 69 between Leyton and Chingford, replacing Routemasters on that section. It was withdrawn temporarily between June 1987 and November 1988 when it was covered by the 69 again. The 97 was operated by London Forest until 1991, when that company was wound up. The route passed to Capital Citybus on 23 November 1991. Route 97 was included in the July 1998 sale of Capital Citybus to First London.
Upon being re-tendered, it was retained by First London with a new contract commencing on 26 February 2000. When next tendered, it passed to Stagecoach London's Leyton garage with a new contract commencing on 5 March 2005. Stagecoach London commenced a further contract on 6 March 2010.
On 10 September 2011, route 97 was extended from Leyton to Stratford City bus station to coincide with the opening of Westfield Stratford City. On 31 August 2013, the route was diverted to serve the new residential precinct around the Queen Elizabeth Olympic Park. Sister route 97A operated from 1981 and 2000 between Chingford and Walthamstow Central with various extensions to Leyton, Hackney and latterly Whipps Cross. It was replaced by route 357.

## Current route

Route 97 operates via these primary locations:
* Chingford station
* Chingford Mount
* Walthamstow Market
* Walthamstow Central station
* Bakers Arms
* Leyton Midland Road station
* Leyton station
* Chobham Academy
* Stratford International station
* Stratford City bus station for Stratford station
# MAP3K2

Mitogen-Activated Protein Kinase Kinase Kinase 2 also known as MEKK2 (MEK/ERK Kinase 2) is an enzyme that in humans is encoded by the MAP3K2 gene.

## Function

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate IkappaB kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process.

## Activation

MEKK2 is activated through homodimerization and subsequent trans-autophosphorylation at MEKK2-S519.
MEKK2 is regulated by 14-3-3 proteins which bind to MEKK2-phosphoT283.
MEKK2 is regulated by SMYD3 which binds and methylates MEKK2-K260.

## Interactions

MAP3K2 has been shown to interact with:
* MAPK8,
* MAP2K4,
* MAP2K5,
* MAP2K7,
* 14-3-3 protein,
* SMYD3,
* SH2D2A, and
* XIAP
# MAP3K3

Mitogen-activated protein kinase kinase kinase 3 is an enzyme that in humans is encoded by the MAP3K3 gene, which is located on the long arm of chromosome 17 (17q23.3).

## Function

This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse MEKK3. Its catalytic domain is closely related to those of several other kinases, including mouse MEKK2, tobacco NPK, and yeast STE11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed.
MAP3Ks are involved in regulating cell fate in response to external stimuli. MAP3K3 directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NF-κB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. MEKK3 regulates the p38, JNK and ERK1/2 pathways.

## Interactions

MAP3K3 has been shown to interact with [SQSTM1/p62],:
* BRCA1, AKT.
* GAB1,
* MAP2K5, and
* YWHAE.

## MAP3K3 in cancer

Two SNPs in the MAP3K3 gene were found as candidates for association with colon and rectal cancers.
MEKK3 is highly expressed in 4 ovarian cancer cell lines (OVCA429, Hey, DOV13, and SKOv3). This expression level is significantly higher in those cancer cells when compared to normal cells. MEKK3 expression levels are comparable to IKK kinase activities, which also relate to activation of NFκB. High expression of MEKK3 in most of these ovarian cancer cells supposedly activate IKK kinase activity, which lead to increased levels of active NFκB. Also, MEKK3 interacts with AKT to activate NFκB. Genes related to cell survival and anti-apoptosis have increased expression in most cancer cells with high levels of MEKK3. This is probably due to constitutive activation of NFκB, which will regulate those genes. In this sense, knockdown of MEKK3 caused ovarian cancer cells to be more sensitive to drugs.
MEKK3 also interacts with BRCA1. Knocking down BRCA1 resulted in inhibited MEKK3 kinase activity. The drug paclitaxel induces MEKK3 activity and it requires functional BRCA1 to do it. It was observed that in a breast cancer cell line BRCA1-deficient (HCC1937), paclitaxel was unable to activate MEKK3. Paclitaxel may be inducing stress-response through the MEKK3/JNK/p38/MAPK pathway, but not in mutated BRCA1 cells.
# MAP3K12

Mitogen-activated protein kinase 12 is an enzyme that in humans is encoded by the MAP3K12 gene.

## Function

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a leucine-zipper domain, and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation.

## Interactions

MAP3K12 has been shown to interact with MAPK8IP1, MAP2K7 and MAPK8IP2.

## Role in development

MAP3K12, otherwise known as DLK, can initiate coordinated signalling cascades that culminate in the phosphorylation of C-Jun N-terminal kinases or JNK. Several experiments have implicated this interaction as having a role in the developing mammalian nervous system. For example, neuronal migration and axon growth are critical components of neuronal development. DLK null mice have defects in neuronal migration, hypoplasia of several different axonal tracts and reduced axon number in various areas of the brain such as the cingulum and internal capsule. In addition, inhibition of DLK or JNK delays radial migration and disrupts the formation of the neocortex in mice. Another important function of the developing mammalian nervous system is neuronal apoptosis. The absence of DLK also protects cultured mice sensory neurons from apoptosis that would normally be triggered by a lack of NGF. This, among other experiments, heavily implicates it as having a role in neuronal apoptosis.
DLK has several different interactions that contribute to mammalian nervous system development. For axon growth, DLK phosphorylates MAP2K4/7 which then phosphorylates JNK, activating it. In neuronal migration DLK phosphorylates MAP2K4/7 which phosphorylates JNK, and also interacts with JIP which then interacts with MAP2K4/7 and JNK. There is a similar interaction for neuronal apoptosis, where DLK phosphorylates JIP3 and MAP2K7, which both phosphorylate JNK. It is evident then that DLK interactions are a versatile and critical part of neuronal development in mammals.
# Lya (name)

Lya is a female first or given name and is usually thought of as a variant of "Lia" or "Leah."
Notable people with the name include:
* Lya Barrioz, Nicaraguan singer
* Lya De Putti (1899–1931), Hungarian actress
* Lya Isabel Fernández Olivares (born 2007), Mexican tennis player
* Lya Imber (1914–1981), Bessarabian-Venezuelan pediatrician
* Lya Ley (1899–1992), Austrian actress
* Lya Luft (born 1938), Brazilian writer
* Lya Lys (1908–1986), German American actress
* Lya Mara (1897–1960), German actress
# Stand By All Networks

Stand by All Networks is a 1942 American thriller film directed by Lew Landers and starring Florence Rice, John Beal and Margaret Hayes. The films sets were designed by Lionel Banks.

## Plot

Before Pearl Harbor, a radio reporter is fired by his station for his "alarmist" broadcasts. He investigates a suspected ring of Nazi saboteurs on his own.

## Cast

* Florence Rice as Frances Prescott
* John Beal as Ben Fallon
* Margaret Hayes as Lela Cramer
* Alan Baxter as Victor
* Mary Treen as Nora Cassidy
* Pierre Watkin as Grant Neeley
* Tim Ryan as Police Inspector Ryan
* Boyd Davis as Colonel Stanton
* Kenneth MacDonald as Captain Banion
* Patrick McVey as Monty Johnson
* Ernie Adams as Sockeye Schaefer
* Sven Hugo Borg as Sailor
* Lloyd Bridges as Slim Terry
* Eddie Laughton as Joe
* Peter Brocco as Cab Driver
* Lee Shumway as Cop
* John Tyrrell as Watchman
* Lester Dorr as Bartender
* Rick Vallin as Sound Control Room Engineer
# Robert W. Mitchell

Robert Wetsel Mitchell (April 25, 1933 – March 18, 2010) was an American invertebrate zoologist and photographer who was particularly active in the study of the biology of caves.
Mitchell was awarded Bachelor of Science (1954) and Master of Science (1955) degrees from Texas Tech University, and Doctor of Philosophy from the University of Texas at Austin in 1961. He was in the United States Air Force Medical Service from 1955 to 1957.
Genera and species Mitchell described include Typhlochactas (1971), Typhlochactas reddelli (1968), Typhlochactas rhodesi (1968) and Sotanochactas elliotti (1971).
Typhlochactas mitchelli or Pseudocellus mitchelli are named in honor of Mitchell.
# Líšnice

Líšnice may refer to places in the Czech Republic:
* Líšnice (Prague-West District), a municipality and village in the Central Bohemian Region
* Líšnice (Šumperk District), a municipality and village in the Olomouc Region
* Líšnice (Ústí nad Orlicí District), a municipality and village in the Pardubice Region
# Stana Izbașa

Stana Izbaşa is a Romanian folkloric music singer from Romania. She began her career by singing Romanian folkloric songs, especially from Banat, but later, after the manele genre flooded the Romanian music market, she began to sing manele. Some of her most famous songs have been duets with other singers such as Adi de Vito and Nicu Paleru. She collaborated with Adi de Vito on the remake of Lepa Brena's (one of ex-Yugoslavia's biggest stars) song "Čik, pogodi".