# List of Major League Baseball players (Sf–So)

The following is a list of Major League Baseball players, retired or active.

## List of Major League Baseball players

* A
* B
* C
* D
* E
* F
* G
* H
* I
* J
* K
* L
* M
* N
* O
* P
* Q
* R
* S
* T
* U
* V
* W
* X
* Y
* Z

## Sh through So

| Name | Debut | Final game | Position | Teams |
| Adam Shabala | June 16, 2005 | July 20, 2005 | Outfielder | San Francisco Giants |
| Brian Shackelford | June 26, 2005 | September 20, 2006 | Pitcher | Cincinnati Reds |
| Orator Shafer | May 23, 1874 | September 13, 1890 | Outfielder | Hartford Dark Blues, New York Mutuals, Philadelphia Athletics (NL), Louisville Grays, Indianapolis Blues, Chicago White Stockings, Cleveland Blues (NL), Buffalo Bisons, St. Louis Maroons, Philadelphia Athletics (AA) |
| Ralph Shafer | July 25, 1914 | July 25, 1914 | Pinch runner | Pittsburgh Pirates |
| Taylor Shafer | April 24, 1884 | September 16, 1890 | Utility player | Altoona Mountain City, Kansas City Cowboys (UA), Baltimore Monumentals, Philadelphia Athletics (AA) |
| Tillie Shafer | April 24, 1909 | October 4, 1913 | Third baseman | New York Giants |
| Shaffer, first name unknown | September 15, 1875 | September 15, 1875 | Outfielder | Brooklyn Atlantics |
| John Shaffer | September 13, 1886 | June 30, 1887 | Pitcher | New York Metropolitans |
| Gus Shallix | June 22, 1884 | June 2, 1885 | Pitcher | Cincinnati Red Stockings (AA) |
| Art Shamsky | April 17, 1965 | July 18, 1972 | Outfielder | Cincinnati Reds, New York Mets, Chicago Cubs, Oakland Athletics |
| Warren Shanabrook | August 13, 1906 | August 13, 1906 | Third baseman | Washington Senators |
| Greg Shanahan | September 7, 1973 | September 30, 1974 | Pitcher | Los Angeles Dodgers |
| Jim Shanley | May 3, 1876 | May 4, 1876 | Outfielder | New York Mutuals |
| Wally Shaner | May 4, 1923 | June 14, 1929 | Outfielder | Cleveland Indians, Boston Red Sox, Cincinnati Reds |
| Harvey Shank | May 16, 1970 | May 16, 1970 | Pitcher | California Angels |
| Howie Shanks | May 9, 1912 | October 3, 1925 | Utility player | Washington Senators, Boston Red Sox, New York Yankees |
| Doc Shanley | September 15. 1912 | September 24, 1912 | Shortstop | St. Louis Browns |
| Bill Shanner | October 1, 1920 | October 1, 1920 | Pitcher | Philadelphia Athletics |
| Dan Shannon | April 17, 1889 | September 16, 1891 | Second baseman | Louisville Colonels, Philadelphia Quakers (PL), New York Giants (PL), Washington Statesmen |
| Frank Shannon | October 1, 1892 | June 20, 1896 | Shortstop | Washington Senators (1891–99), Louisville Colonels |
| Joe Shannon | June 30, 1915 | October 7, 1915 | Outfielder | Boston Braves |
| Mike Shannon | September 11, 1962 | August 12, 1970 | Utility player | St. Louis Cardinals |
| Owen Shannon | September 6, 1903 | August 24, 1907 | Catcher | St. Louis Browns, Washington Senators |
| Red Shannon | October 7, 1915 | June 2, 1926 | Utility infielder | Boston Braves, Philadelphia Athletics, Boston Red Sox, Washington Senators, Chicago Cubs |
| Spike Shannon | April 15, 1904 | September 30, 1908 | Outfielder | St. Louis Cardinals, New York Giants, Pittsburgh Pirates |
| Wally Shannon | July 9, 1959 | May 26, 1960 | Utility infielder | St. Louis Cardinals |
| Billy Shantz | April 13, 1954 | June 29, 1960 | Catcher | Philadelphia/Kansas City Athletics, New York Yankees |
| Bobby Shantz | May 1, 1949 | September 29, 1964 | Pitcher | Philadelphia/Kansas City Athletics, New York Yankees, Pittsburgh Pirates, Houston Colt .45s, St. Louis Cardinals, Chicago Cubs, Philadelphia Phillies |
| Ralph Sharman | September 10, 1917 | October 3, 1917 | Outfielder | Philadelphia Athletics |
| Dick Sharon | May 13, 1973 | September 28, 1975 | Outfielder | Detroit Tigers, San Diego Padres |
| Bill Sharp | May 26, 1973 | September 17, 1976 | Outfielder | Chicago White Sox, Milwaukee Brewers |
| Bud Sharpe | April 14, 1905 | September 24, 1910 | First baseman | Boston Beaneaters, Boston Doves, Pittsburgh Pirates |
| Mike Sharperson | April 6, 1987 | July 15, 1995 | Third baseman | Toronto Blue Jays, Los Angeles Dodgers, Atlanta Braves |
| Josh Sharpless | August 1, 2006 | | Pitcher | Pittsburgh Pirates |
| George Sharrott | July 27, 1893 | May 4, 1894 | Pitcher | Brooklyn Grooms |
| Jack Sharrott | April 22, 1890 | September 30, 1893 | Pitcher | New York Giants, Philadelphia Phillies |
| Shag Shaughnessy | April 17, 1905 | June 20, 1908 | Outfielder | Washington Senators, Philadelphia Athletics |
| Joe Shaute | July 6, 1922 | May 24, 1934 | Pitcher | Cleveland Indians, Brooklyn Dodgers, Cincinnati Reds |
| Jon Shave | May 15, 1993 | October 3, 1999 | Utility infielder | Texas Rangers, Minnesota Twins |
| Jeff Shaver | July 6, 1988 | July 6, 1988 | Pitcher | Oakland Athletics |
| Al Shaw (C) | June 8, 1901 | September 13, 1909 | Catcher | Detroit Tigers, Boston Americans, Chicago White Sox, Boston Doves |
| Al Shaw (OF) | September 28, 1907 | October 3, 1915 | Outfielder | St. Louis Cardinals, Brooklyn Tip-Tops, Kansas City Packers |
| Ben Shaw | April 11, 1917 | August 27, 1918 | First baseman | Pittsburgh Pirates |
| Bob Shaw | August 11, 1957 | September 11, 1967 | Pitcher | Detroit Tigers, Chicago White Sox, Kansas City Athletics, Milwaukee Braves, San Francisco Giants, New York Mets, Chicago Cubs |
| Bryan Shaw | June 10, 2011 | | Pitcher | Arizona Diamondbacks |
| Don Shaw | April 11, 1967 | May 19, 1972 | Pitcher | New York Mets, Montreal Expos, St. Louis Cardinals, Oakland Athletics |
| Dupee Shaw | June 18, 1883 | July 17, 1888 | Pitcher | Detroit Wolverines, Boston Reds (UA), Providence Grays, Washington Nationals (1886–1889) |
| Hunky Shaw | May 16, 1908 | May 16, 1908 | Pinch hitter | Pittsburgh Pirates |
| Jeff Shaw | April 30, 1990 | October 6, 2001 | Pitcher | Cleveland Indians, Montreal Expos, Chicago White Sox, Cincinnati Reds, Los Angeles Dodgers |
| Jim Shaw | September 15, 1913 | July 13, 1921 | Pitcher | Washington Senators |
| Sam Shaw | May 3, 1888 | June 16, 1893 | Pitcher | Baltimore Orioles (19th century), Chicago Colts |
| Bob Shawkey | July 16, 1913 | September 29, 1927 | Pitcher | Philadelphia Athletics, New York Yankees |
| Danny Shay | April 30, 1901 | September 10, 1907 | Shortstop | Cleveland Blues (AL), St. Louis Cardinals, New York Giants |
| Marty Shay | September 16, 1916 | September 2, 1924 | Second baseman | Chicago Cubs, Boston Braves |
| Gerry Shea | October 1, 1905 | October 3, 1905 | Catcher | St. Louis Cardinals |
| John Shea | June 30, 1928 | June 30, 1928 | Pitcher | Boston Red Sox |
| Merv Shea | April 23, 1927 | August 19, 1944 | Catcher | Detroit Tigers, Boston Red Sox, St. Louis Browns, Chicago White Sox, Brooklyn Dodgers, Philadelphia Phillies |
| Mike Shea | April 20, 1887 | April 26, 1887 | Pitcher | Cincinnati Red Stockings (AA) |
| Nap Shea | September 11, 1902 | September 15, 1902 | Catcher | Philadelphia Phillies |
| Red Shea | May 6, 1918 | June 9, 1922 | Pitcher | Philadelphia Athletics, New York Giants |
| Spec Shea | April 19, 1947 | August 27, 1955 | Pitcher | New York Yankees, Washington Senators |
| Steve Shea | July 14, 1968 | May 31, 1969 | Pitcher | Houston Astros, Montreal Expos |
| Danny Sheaffer | April 9, 1987 | September 27, 1997 | Catcher | Boston Red Sox, Cleveland Indians, Colorado Rockies, St. Louis Cardinals |
| Al Shealy | April 13, 1928 | September 3, 1930 | Pitcher | New York Yankees, Chicago Cubs |
| Ryan Shealy | June 14, 2005 | | First baseman | Colorado Rockies, Kansas City Royals, Boston Red Sox |
| Dave Shean | September 10, 1906 | July 17, 1919 | Second baseman | Philadelphia Athletics, Philadelphia Phillies, Boston Doves, Chicago Cubs, Boston Braves, Cincinnati Reds, Boston Red Sox |
| Ray Shearer | September 18, 1957 | September 29, 1957 | Outfielder | Milwaukee Braves |
| Tom Shearn | August 26, 2007 | September 26, 2007 | Pitcher | Cincinnati Reds |
| John Shearon | July 28, 1891 | May 9, 1896 | Outfielder | Cleveland Spiders |
| George Shears | April 24, 1912 | June 20, 1912 | Pitcher | New York Highlanders |
| Jimmy Sheckard | September 14, 1897 | September 28, 1914 | Outfielder | Brooklyn Bridegrooms, Baltimore Orioles (19th century), Brooklyn Superbas, Baltimore Orioles, Chicago Cubs, St. Louis Cardinals, Cincinnati Reds |
| Biff Sheehan | July 22, 1895 | May 10, 1896 | Outfielder | St. Louis Browns (1882–1900) |
| Dan Sheahan | April 19, 1884 | August 23, 1884 | Outfielder | Washington Nationals (UA), Wilmington Quicksteps |
| Jack Sheehan | September 11, 1920 | May 16, 1921 | Utility infielder | Brooklyn Robins |
| Jim Sheehan | September 26, 1936 | September 26, 1936 | Catcher | New York Giants |
| Tom Sheehan | July 14, 1915 | May 27, 1926 | Pitcher | Philadelphia Athletics, New York Yankees, Cincinnati Reds, Pittsburgh Pirates |
| Tommy Sheehan | August 2, 1900 | October 7, 1908 | Third baseman | New York Giants, Pittsburgh Pirates, Brooklyn Superbas |
| Bud Sheely | July 26, 1951 | September 13, 1953 | Catcher | Chicago White Sox |
| Earl Sheely | April 14, 1921 | September 27, 1931 | First baseman | Chicago White Sox, Pittsburgh Pirates, Boston Braves |
| Chuck Sheerin | April 21, 1936 | September 27, 1936 | Utility infielder | Philadelphia Phillies |
| Andy Sheets | April 22, 1996 | September 25, 2002 | Shortstop | Seattle Mariners, San Diego Padres, Anaheim Angels, Boston Red Sox, Tampa Bay Devil Rays |
| Ben Sheets | April 5, 2001 | | Pitcher | Milwaukee Brewers, Oakland Athletics |
| Larry Sheets | September 18, 1984 | October 1, 1993 | Outfielder | Baltimore Orioles, Detroit Tigers, Seattle Mariners |
| Gary Sheffield | September 3, 1988 | | Outfielder | Milwaukee Brewers, San Diego Padres, Florida Marlins, Los Angeles Dodgers, Atlanta Braves, New York Yankees, Detroit Tigers, New York Mets |
| John Shelby | September 15, 1981 | August 11, 1991 | Outfielder | Baltimore Orioles, Los Angeles Dodgers, Detroit Tigers |
| Bob Sheldon | April 10, 1974 | July 17, 1977 | Second baseman | Milwaukee Brewers |
| Rollie Sheldon | April 23, 1961 | September 25, 1966 | Pitcher | New York Yankees, Kansas City Athletics, Boston Red Sox |
| Scott Sheldon | May 18, 1997 | October 5, 2001 | Utility infielder | Oakland Athletics, Texas Rangers |
| Steven Shell | June 22, 2008 | | Pitcher | Washington Nationals |
| Frank Shellenback | May 8, 1918 | July 5, 1919 | Pitcher | Chicago White Sox |
| Jim Shellenback | September 15, 1966 | September 21, 1977 | Pitcher | Pittsburgh Pirates, Washington Senators (1961–1971), Texas Rangers, Minnesota Twins |
| Hugh Shelley | June 25, 1935 | September 29, 1935 | Outfielder | Detroit Tigers |
| Ben Shelton | June 16, 1993 | July 25, 1993 | Outfielder | Pittsburgh Pirates |
| Chris Shelton | April 15, 2004 | | First baseman | Detroit Tigers, Texas Rangers, Seattle Mariners |
| Skeeter Shelton | August 25, 1915 | September 1, 1915 | Outfielder | New York Yankees |
| Steve Shemo | April 18, 1944 | July 16, 1945 | Second baseman | Boston Braves |
| Bert Shepard | August 4, 1945 | August 4, 1945 | Pitcher | Washington Senators |
| Jack Shepard | June 19, 1953 | September 30, 1956 | Catcher | Pittsburgh Pirates |
| Ray Shepardson | September 19, 1924 | September 24, 1924 | Catcher | St. Louis Cardinals |
| Keith Shepherd | September 6, 1992 | August 4, 1996 | Pitcher | Philadelphia Phillies, Colorado Rockies, Boston Red Sox, Baltimore Orioles |
| Ron Shepherd | September 5, 1984 | October 5, 1986 | Outfielder | Toronto Blue Jays |
| John Sheppard | June 27, 1873 | July 11, 1873 | Outfielder | Baltimore Marylands |
| Bill Sherdel | April 22, 1918 | June 11, 1932 | Pitcher | St. Louis Cardinals, Boston Braves |
| Roy Sherid | May 11, 1929 | June 21, 1931 | Pitcher | New York Yankees |
| Sheridan, first name unknown | October 9, 1875 | October 9, 1875 | Outfielder | Brooklyn Atlantics |
| Neill Sheridan | September 19, 1948 | September 26, 1948 | Pinch hitter | Boston Red Sox |
| Pat Sheridan | September 16, 1981 | October 5, 1991 | Outfielder | Kansas City Royals, Detroit Tigers, San Francisco Giants, New York Yankees |
| Red Sheridan | July 3, 1918 | October 1, 1920 | Utility infielder | Brooklyn Robins |
| Ed Sherling | August 13, 1924 | September 17, 1924 | Pinch hitter | Philadelphia Athletics |
| Monk Sherlock | April 20, 1930 | September 28, 1930 | First baseman | Philadelphia Phillies |
| Vince Sherlock | September 18, 1935 | September 29, 1935 | Second baseman | Brooklyn Dodgers |
| Dan Sherman | June 4, 1914 | June 4, 1914 | Pitcher | Chicago Chi-Feds |
| Darrell Sherman | April 8, 1993 | May 22, 1993 | Outfielder | San Diego Padres |
| Joe Sherman | September 24, 1915 | September 30, 1915 | Pitcher | Philadelphia Athletics |
| Dennis Sherrill | September 4, 1978 | June 28, 1980 | Utility infielder | New York Yankees |
| George Sherrill | July 16, 2004 | | Pitcher | Seattle Mariners, Baltimore Orioles, Los Angeles Dodgers, Atlanta Braves |
| Tim Sherrill | August 14, 1990 | June 16, 1991 | Pitcher | St. Louis Cardinals |
| Fred Sherry | April 25, 1911 | June 28, 1911 | Pitcher | Washington Senators |
| Larry Sherry | April 17, 1958 | July 7, 1968 | Pitcher | Los Angeles Dodgers, Detroit Tigers, Houston Astros, California Angels |
| Norm Sherry | April 12, 1959 | September 26, 1963 | Catcher | Los Angeles Dodgers, New York Mets |
| Barry Shetrone | July 27, 1959 | June 7, 1963 | Outfielder | Baltimore Orioles, Washington Senators (1961–1971) |
| John Shetzline | May 2, 1882 | September 30, 1882 | Third baseman | Baltimore Orioles (19th century) |
| Jimmy Shevlin | June 29, 1930 | July 25, 1934 | First baseman | Detroit Tigers, Cincinnati Reds |
| Ben Shields | April 17, 1924 | May 23, 1931 | Pitcher | New York Yankees, Boston Red Sox, Philadelphia Phillies |
| Charlie Shields | April 23, 1902 | June 10, 1907 | Pitcher | Baltimore Orioles (1901–02), St. Louis Browns, St. Louis Cardinals |
| James Shields | May 31, 2006 | | Pitcher | Tampa Bay Devil Rays/Rays |
| Pete Shields | April 14, 1915 | May 16, 1915 | First baseman | Cleveland Indians |
| Scot Shields | May 26, 2001 | | Pitching | Anaheim Angels/Los Angeles Angels of Anaheim |
| Steve Shields | June 1, 1985 | June 19, 1989 | Pitcher | Atlanta Braves, Kansas City Royals, Seattle Mariners, New York Yankees, Minnesota Twins |
| Tommy Shields | July 25, 1992 | October 3, 1993 | Utility infielder | Baltimore Orioles, Chicago Cubs |
| Vince Shields | September 20, 1924 | September 25, 1924 | Pitcher | St. Louis Cardinals |
| Jason Shiell | September 8, 2002 | August 5, 2006 | Pitcher | San Diego Padres, Boston Red Sox, Atlanta Braves |
| Garland Shifflett | August 22, 1957 | June 26, 1964 | Pitcher | Washington Senators, Minnesota Twins |
| Steve Shifflett | July 3, 1992 | October 4, 1992 | Pitcher | Kansas City Royals |
| Jim Shilling | April 21, 1939 | September 30, 1939 | Second baseman | Cleveland Indians, Philadelphia Phillies |
| Zak Shinall | May 12, 1993 | May 12, 1993 | Pitcher | Seattle Mariners |
| Ginger Shinault | July 4, 1921 | August 1, 1922 | Catcher | Cleveland Indians |
| Billy Shindle | October 5, 1886 | September 17, 1898 | Third baseman | Detroit Wolverines, Baltimore Orioles (19th century), Philadelphia Quakers (PL), Philadelphia Phillies, Brooklyn Grooms/Bridegrooms |
| Razor Shines | September 9, 1983 | May 14, 1987 | First baseman | Montreal Expos |
| Tsuyoshi Shinjo | April 3, 2001 | June 27, 2003 | Outfielder | New York Mets, San Francisco Giants |
| Ralph Shinners | April 12, 1922 | September 23, 1925 | Outfielder | New York Giants, San Francisco Giants |
| Tim Shinnick | April 19, 1890 | October 4, 1891 | Second baseman | Louisville Colonels |
| Dave Shipanoff | August 10, 1985 | October 5, 1985 | Pitcher | Philadelphia Phillies |
| Bill Shipke | April 23, 1906 | May 13, 1909 | Third baseman | Cleveland Naps, Washington Senators |
| Craig Shipley | June 22, 1986 | September 25, 1998 | Utility infielder | Los Angeles Dodgers, New York Mets, San Diego Padres, Houston Astros, Anaheim Angels |
| Joe Shipley | July 14, 1958 | July 23, 1963 | Pitcher | San Francisco Giants, Chicago White Sox |
| Art Shires | August 20, 1928 | July 31, 1932 | First baseman | Chicago White Sox, Washington Senators, Boston Braves |
| Duke Shirey | September 28, 1920 | October 3, 1920 | Pitcher | Washington Senators |
| Bart Shirley | September 14, 1964 | September 29, 1968 | Utility infielder | Los Angeles Dodgers, New York Mets |
| Bob Shirley | April 10, 1977 | June 21, 1987 | Pitcher | San Diego Padres, St. Louis Cardinals, Cincinnati Reds, New York Yankees, Kansas City Royals |
| Mule Shirley | May 6, 1924 | July 12, 1925 | First baseman | Washington Senators |
| Steve Shirley | June 21, 1982 | July 30, 1982 | Pitcher | Los Angeles Dodgers |
| Tex Shirley | September 6, 1941 | September 21, 1946 | Pitcher | Philadelphia Athletics, St. Louis Browns |
| Ivey Shiver | April 14, 1931 | May 13, 1934 | Outfielder | Detroit Tigers, Cincinnati Reds |
| George Shoch | September 10, 1886 | October 2, 1897 | Utility player | Washington Nationals (1886–1889), Milwaukee Brewers (AA), Baltimore Orioles (19th century), Brooklyn Grooms/Bridegrooms |
| Urban Shocker | April 24, 1916 | May 30, 1928 | Pitcher | New York Yankees, St. Louis Browns |
| Costen Shockley | July 17, 1964 | June 7, 1965 | First baseman | Philadelphia Phillies, California Angels |
| Charlie Shoemaker | September 9, 1961 | July 26, 1964 | Second baseman | Kansas City Athletics |
| Milt Shoffner | July 20, 1929 | September 22, 1940 | Pitcher | Cleveland Indians, Boston Bees, Cincinnati Reds |
| Strick Shofner | April 19, 1947 | April 29, 1947 | Third baseman | Boston Red Sox |
| Eddie Shokes | June 9, 1941 | September 29, 1946 | First baseman | Cincinnati Reds |
| Ray Shook | April 16, 1916 | April 16, 1916 | Pinch runner | Chicago White Sox |
| Ron Shoop | August 22, 1959 | September 27, 1959 | Catcher | Detroit Tigers |
| Tom Shopay | September 17, 1967 | September 30, 1977 | Outfielder | New York Yankees, Baltimore Orioles |
| Kelly Shoppach | May 28, 2005 | | Catcher | Boston Red Sox, Cleveland Indians, Tampa Bay Rays |
| Ernie Shore | June 20, 1912 | August 22, 1920 | Pitcher | New York Giants, Boston Red Sox, New York Yankees |
| Ray Shore | September 21, 1946 | July 4, 1949 | Pitcher | St. Louis Browns |
| Bill Shores | April 11, 1928 | September 20, 1936 | Pitcher | Philadelphia White Sox, New York Giants, Chicago White Sox |
| Bill Short | April 23, 1960 | June 13, 1969 | Pitcher | New York Yankees, Baltimore Orioles, Boston Red Sox, Pittsburgh Pirates, New York Mets, Cincinnati Reds |
| Chris Short | April 19, 1959 | September 18, 1973 | Pitcher | Philadelphia Phillies, Milwaukee Brewers |
| Dave Short | September 16, 1940 | April 29, 1941 | Outfielder | Chicago White Sox |
| Rick Short | June 10, 2005 | September 23, 2005 | Second baseman | Washington Nationals |
| Chick Shorten | September 22, 1915 | September 24, 1924 | Outfielder | Boston Red Sox, Detroit Tigers, St. Louis Browns, Cincinnati Reds |
| Burt Shotton | September 13, 1909 | April 21, 1923 | Outfielder | St. Louis Browns, Washington Senators, St. Louis Cardinals |
| Clyde Shoun | August 7, 1935 | July 19, 1949 | Pitcher | Chicago Cubs, St. Louis Cardinals, Cincinnati Reds, Boston Braves, Chicago White Sox |
| John Shoupe | May 3, 1879 | May 28, 1884 | Shortstop | Troy Trojans, St. Louis Brown Stockings (AA), Washington Nationals (UA) |
| Brian Shouse | July 31, 1993 | | Pitcher | Pittsburgh Pirates, Boston Red Sox, Kansas City Royals, Texas Rangers, Milwaukee Brewers, Tampa Bay Rays |
| John Shovlin | June 21, 1911 | May 12, 1920 | Second baseman | Pittsburgh Pirates, St. Louis Browns |
| Eric Show | September 2, 1981 | September 30, 1991 | Pitcher | San Diego Padres, Oakland Athletics |
| Lev Shreve | May 2, 1887 | September 27, 1889 | Pitcher | Baltimore Orioles, Indianapolis Hoosiers (NL) |
| Harry Shriver | April 14, 1922 | April 20, 1923 | Pitcher | Brooklyn Robins |
| George Shuba | July 2, 1948 | September 25, 1955 | Outfielder | Brooklyn Dodgers |
| J. B. Shuck | August 5, 2011 | | Outfielder | Houston Astros |
| Paul Shuey | May 8, 1994 | August 26, 2007 | Pitcher | Cleveland Indians, Los Angeles Dodgers, Baltimore Orioles |
| Frank Shugart | August 23, 1890 | September 27, 1901 | Shortstop | Chicago Pirates, Pittsburgh Pirates, St. Louis Cardinals, Louisville Colonels, Philadelphia Phillies, Chicago White Stockings (AL) |
| Toots Shultz | May 5, 1911 | September 13, 1912 | Pitcher | Philadelphia Phillies |
| Anthony Shumaker | July 23, 1999 | October 2, 1999 | Pitcher | Philadelphia Phillies |
| Harry Shuman | September 14, 1942 | September 26, 1944 | Pitcher | Pittsburgh Pirates, Philadelphia Phillies |
| Terry Shumpert | May 1, 1990 | September 28, 2003 | Second baseman | Kansas City Royals, Boston Red Sox, Chicago Cubs, San Diego Padres, Colorado Rockies, Tampa Bay Devil Rays |
| Vince Shupe | July 7, 1945 | September 30, 1945 | First baseman | Boston Braves |
| Ed Sicking | August 26, 1916 | May 3, 1927 | Utility infielder | Chicago Cubs, New York Giants, Philadelphia Phillies, Cincinnati Reds, Pittsburgh Pirates |
| Joe Siddall | July 28, 1993 | September 26, 1998 | Catcher | Montreal Expos, Florida Marlins, Detroit Tigers |
| Norm Siebern | June 15, 1956 | July 30, 1968 | First baseman | New York Yankees, Kansas City Athletics, Baltimore Orioles, California Angels, San Francisco Giants, Boston Red Sox |
| Dick Siebert | September 7, 1932 | September 23, 1945 | First baseman | Brooklyn Dodgers, St. Louis Cardinals, Philadelphia Athletics |
| Paul Siebert | September 7, 1974 | September 24, 1978 | Pitcher | Houston Astros, San Diego Padres, New York Mets |
| Sonny Siebert | April 26, 1964 | September 25, 1975 | Pitcher | Cleveland Indians, Boston Red Sox, Texas Rangers, St. Louis Cardinals, San Diego Padres, Oakland Athletics |
| Dwight Siebler | August 26, 1963 | April 30, 1967 | Pitcher | Minnesota Twins |
| Fred Siefke | May 2, 1890 | June 1, 1890 | Third baseman | Brooklyn Gladiators |
| Fred Siegel | June 9, 1884 | June 24, 1884 | Third baseman | Philadelphia Keystones |
| Johnny Siegle | September 15, 1905 | October 7, 1906 | Outfielder | Cincinnati Reds |
| Oscar Siemer | May 20, 1925 | September 18, 1926 | Catcher | Boston Braves |
| Candy Sierra | April 6, 1988 | June 10, 1988 | Pitcher | San Diego Padres, Cincinnati Reds |
| Rubén Sierra | June 1, 1986 | July 9, 2006 | Outfielder | Texas Rangers, Oakland Athletics, New York Yankees, Detroit Tigers, Cincinnati Reds, Toronto Blue Jays, Chicago White Sox, Seattle Mariners, Minnesota Twins |
| Ed Siever | April 26, 1901 | June 18, 1908 | Pitcher | Detroit Tigers, St. Louis Browns |
| Roy Sievers | April 21, 1949 | May 9, 1965 | Utility player | St. Louis Browns, Washington Senators, Chicago White Sox, Philadelphia Phillies, Washington Senators (1961–1971) |
| Frank Siffell | June 14, 1884 | September 16, 1885 | Catcher | Philadelphia Athletics (AA) |
| Frank Sigafoos | September 3, 1926 | May 30, 1931 | Utility infielder | Philadelphia Athletics, Detroit Tigers, Chicago White Sox, Cincinnati Reds |
| Paddy Siglin | September 12, 1914 | September 30, 1916 | Second baseman | Pittsburgh Pirates |
| Tripp Sigman | September 18, 1929 | August 28, 1930 | Outfielder | Philadelphia Phillies |
| Walter Signer | September 18, 1943 | July 22, 1945 | Pitcher | Chicago Cubs |
| Seth Sigsby | June 27, 1893 | June 27, 1893 | Pitcher | New York Giants |
| Brian Sikorski | August 16, 2000 | September 29, 2006 | Pitcher | Texas Rangers, San Diego Padres, Cleveland Indians |
| Eddie Silber | September 3, 1937 | April 30, 1939 | Outfielder | St. Louis Browns |
| Ed Silch | April 29, 1888 | July 8, 1888 | Outfielder | Brooklyn Bridegrooms |
| Carlos Silva | April 1, 2002 | | Pitcher | Philadelphia Phillies, Minnesota Twins, Seattle Mariners, Chicago Cubs |
| Danny Silva | August 11, 1919 | August 11, 1919 | Third baseman | Washington Senators |
| José Silva | September 10, 1996 | September 28, 2002 | Pitcher | Toronto Blue Jays, Pittsburgh Pirates, Cincinnati Reds |
| Walter Silva | April 8, 2009 | | Pitcher | San Diego Padres |
| Al Silvera | June 12, 1955 | May 8, 1956 | Outfielder | Cincinnati Redlegs |
| Charlie Silvera | September 29, 1948 | September 28, 1957 | Catcher | New York Yankees, Chicago Cubs |
| Luis Silverio | September 9, 1978 | September 30, 1978 | Outfielder | Kansas City Royals |
| Tom Silverio | April 30, 1970 | May 15, 1972 | Outfielder | California Angels |
| Dave Silvestri | April 27, 1992 | May 16, 1999 | Utility infielder | New York Yankees, Montreal Expos, Texas Rangers, Tampa Bay Devil Rays, Anaheim Angels |
| Ken Silvestri | April 18, 1939 | July 31, 1951 | Catcher | Chicago White Sox, New York Yankees, Philadelphia Phillies |
| Al Sima | June 28, 1950 | September 19, 1954 | Pitcher | Washington Senators, Chicago White Sox, Philadelphia Athletics |
| Bill Simas | August 15, 1995 | September 30, 2000 | Pitcher | Chicago White Sox |
| Al Simmons β | April 15, 1924 | July 1, 1944 | Outfielder | Philadelphia Athletics, Chicago White Sox, Detroit Tigers, Washington Senators, Boston Bees, Cincinnati Reds, Boston Red Sox |
| Brian Simmons | September 21, 1998 | October 7, 2001 | Outfielder | Chicago White Sox, Toronto Blue Jays |
| Curt Simmons | September 28, 1947 | October 1, 1967 | Pitcher | Philadelphia Phillies, St. Louis Cardinals, Chicago Cubs, California Angels |
| Hack Simmons | April 15, 1910 | June 30, 1915 | Second baseman | Detroit Tigers, New York Highlanders, Baltimore Terrapins |
| Joe Simmons | May 8, 1971 | June 14, 1875 | Outfielder | Chicago White Stockings, Cleveland Forest Citys, Keokuk Westerns |
| John Simmons | April 22, 1949 | September 25, 1949 | Outfielder | Washington Senators |
| Nelson Simmons | September 4, 1984 | May 8, 1987 | Outfielder | Detroit Tigers, Baltimore Orioles |
| Pat Simmons | April 18, 1928 | October 6, 1929 | Pitcher | Boston Red Sox |
| Ted Simmons | September 21, 1968 | October 2, 1988 | Catcher | St. Louis Cardinals, Milwaukee Brewers, Atlanta Braves |
| Mike Simms | September 5, 1990 | October 3, 1999 | Outfielder | Houston Astros, Texas Rangers |
| Alfredo Simón | September 6, 2008 | | Pitcher | Baltimore Orioles |
| Hank Simon | October 7, 1887 | October 12, 1890 | Outfielder | Cleveland Blues, Brooklyn Gladiators, Syracuse Stars (AA) |
| Mike Simon | June 27, 1909 | September 30, 1915 | Catcher | Pittsburgh Pirates, St. Louis Terriers, Brooklyn Tip-Tops |
| Randall Simon | September 1, 1997 | September 30, 2006 | First baseman | Atlanta Braves, Detroit Tigers, Pittsburgh Pirates, Chicago Cubs, Tampa Bay Devil Rays, Philadelphia Phillies |
| Syl Simon | October 1, 1923 | September 27, 1924 | Utility infielder | St. Louis Browns |
| Doug Simons | April 9, 1991 | September 24, 1992 | Pitcher | New York Mets, Montreal Expos |
| Mel Simons | April 14, 1931 | April 20, 1932 | Outfielder | Chicago White Sox |
| Jason Simontacchi | May 4, 2002 | July 15, 2007 | Pitcher | St. Louis Cardinals, Washington Nationals |
| Allan Simpson | May 17, 2004 | June 9, 2006 | Pitcher | Colorado Rockies, Cincinnati Reds, Milwaukee Brewers |
| Dick Simpson | September 21, 1962 | August 27, 1969 | Outfielder | Los Angeles/California Angels, Cincinnati Reds, St. Louis Cardinals, Houston Astros, New York Yankees, Seattle Pilots |
| Duke Simpson | May 6, 1953 | September 17, 1953 | Pitcher | Chicago Cubs |
| Harry Simpson | April 21, 1951 | September 27, 1959 | Outfielder | Cleveland Indians, Kansas City Athletics, New York Yankees, Chicago White Sox, Pittsburgh Pirates |
| Joe Simpson | September 2, 1975 | October 1, 1983 | Outfielder | Los Angeles Dodgers, Seattle Mariners, Kansas City Royals |
| Marty Simpson | May 14, 1873 | July 11, 1873 | Second baseman | Baltimore Marylands |
| Steve Simpson | September 10, 1972 | October 3, 1972 | Pitcher | San Diego Padres |
| Wayne Simpson | April 9, 1970 | September 29, 1977 | Pitcher | Cincinnati Reds, Kansas City Royals, Philadelphia Phillies, California Angels |
| Duke Sims | September 22, 1964 | September 26, 1974 | Catcher | Cleveland Indians, Los Angeles Dodgers, Detroit Tigers, New York Yankees, Texas Rangers |
| Greg Sims | April 15, 1966 | May 19, 1966 | Outfielder | Houston Astros |
| Pete Sims | September 16, 1915 | September 23, 1915 | Pitcher | St. Louis Browns |
| Matt Sinatro | September 22, 1981 | May 26, 1992 | Catcher | Atlanta Braves, Oakland Athletics, Detroit Tigers, Seattle Mariners |
| Steve Sinclair | April 25, 1998 | October 3, 1999 | Pitcher | Toronto Blue Jays, Seattle Mariners |
| Bert Sincock | June 25, 1908 | June 25, 1908 | Pitcher | Cincinnati Reds |
| Hosea Siner | July 28, 1909 | August 23, 1909 | Third baseman | Boston Doves |
| Bill Singer | September 24, 1964 | July 16, 1977 | Pitcher | Los Angeles Dodgers, California Angels, Texas Rangers, Minnesota Twins, Toronto Blue Jays |
| Chris Singleton | April 10, 1999 | May 19, 2005 | Outfielder | Chicago White Sox, Baltimore Orioles, Oakland Athletics, Tampa Bay Devil Rays |
| Duane Singleton | August 4, 1994 | June 6, 1996 | Outfielder | Milwaukee Brewers, Detroit Tigers |
| Elmer Singleton | August 20, 1945 | August 1, 1959 | Pitcher | Boston Braves, Pittsburgh Pirates, Washington Senators, Chicago Cubs |
| John Singleton | June 8, 1922 | September 22, 1922 | Pitcher | Philadelphia Phillies |
| Ken Singleton | June 24, 1970 | September 25, 1984 | Outfielder | New York Mets, Montreal Expos, Baltimore Orioles |
| Fred Sington | September 23, 1934 | June 16, 1939 | Outfielder | Washington Senators, Brooklyn Dodgers |
| Brett Sinkbeil | September 15, 2010 | | Pitcher | Florida Marlins |
| Dick Sipek | April 28, 1945 | September 29, 1945 | Outfielder | Cincinnati Reds |
| John Sipin | May 24, 1969 | August 27, 1969 | Second baseman | San Diego Padres |
| Tony Sipp | April 22, 2009 | | Pitcher | Cleveland Indians |
| Mike Sirotka | July 19, 1995 | September 28, 2000 | Pitcher | Chicago White Sox |
| Andrew Sisco | April 4, 2005 | | Pitcher | Kansas City Royals, Chicago White Sox |
| Steve Sisco | May 6, 2000 | September 30, 2000 | Utility player | Atlanta Braves |
| Doug Sisk | September 6, 1982 | May 23, 1991 | Pitcher | New York Mets, Baltimore Orioles, Atlanta Braves |
| Tommie Sisk | July 19, 1962 | June 14, 1970 | Pitcher | Pittsburgh Pirates, San Diego Padres, Chicago White Sox |
| Dave Sisler | April 21, 1956 | September 23, 1962 | Pitcher | Boston Red Sox, Chicago White Sox, Washington Senators (1961–1971), Cincinnati Reds |
| Dick Sisler | April 16, 1946 | August 1, 1953 | First baseman | St. Louis Cardinals, Philadelphia Phillies, Cincinnati Reds |
| George Sisler β | June 28, 1915 | September 22, 1930 | First baseman | St. Louis Browns, Washington Senators, Boston Braves |
| Sibby Sisti | July 21, 1939 | June 6, 1954 | Utility infielder | Boston/Milwaukee Braves |
| Carl Sitton | April 24, 1909 | September 2, 1909 | Pitcher | Cleveland Naps |
| Pete Sivess | June 13, 1936 | October 2, 1938 | Pitcher | Philadelphia Phillies |
| Jim Siwy | August 20, 1982 | May 12, 1984 | Pitcher | Chicago White Sox |
| Ed Sixsmith | September 11, 1884 | September 11, 1884 | Catcher | Philadelphia Quakers |
| Grady Sizemore | July 21, 2004 | | Outfielder | Cleveland Indians |
| Scott Sizemore | April 5, 2010 | | Second baseman | Detroit Tigers, Oakland Athletics |
| Ted Sizemore | April 7, 1969 | May 27, 1980 | Second baseman | Los Angeles Dodgers, St. Louis Cardinals, Philadelphia Phillies, Chicago Cubs, Boston Red Sox |
| Frank Skaff | September 11, 1935 | October 3, 1943 | First baseman | Los Angeles Dodgers, Philadelphia Athletics |
| Dave Skaggs | April 17, 1977 | October 4, 1980 | Catcher | Baltimore Orioles, California Angels |
| Joe Skalski | April 10, 1989 | April 14, 1989 | Pitcher | Cleveland Indians |
| Dave Skaugstad | September 25, 1957 | September 29, 1957 | Pitcher | Cincinnati Redlegs |
| Dave Skeels | September 14, 1910 | September 14, 1910 | Pitcher | Detroit Tigers |
| Bud Sketchley | April 14, 1942 | April 29, 1942 | Outfielder | Chicago White Sox |
| Roe Skidmore | September 17, 1970 | September 17, 1970 | Pinch hitter | Chicago Cubs |
| Bill Skiff | May 17, 1921 | September 26, 1926 | Catcher | Pittsburgh Pirates, New York Yankees |
| Al Skinner | July 12, 1884 | July 16, 1884 | Outfielder | Baltimore Monumentals, Chicago Browns/Pittsburgh Stogies |
| Bob Skinner | April 13, 1954 | September 24, 1966 | Outfielder | Pittsburgh Pirates, Cincinnati Reds, St. Louis Cardinals |
| Camp Skinner | May 2, 1922 | May 6, 1923 | Outfielder | New York Yankees, Boston Red Sox |
| Joel Skinner | June 12, 1983 | September 22, 1991 | Catcher | Chicago White Sox, New York Yankees, Cleveland Indians |
| Lou Skizas | April 19, 1956 | April 30, 1959 | Outfielder | New York Yankees, Kansas City Royals, Detroit Tigers, Chicago White Sox |
| Craig Skok | May 4, 1973 | July 29, 1979 | Pitcher | Boston Red Sox, Texas Rangers, Atlanta Braves |
| John Skopec | April 25, 1901 | September 11, 1903 | Pitcher | Chicago White Stockings (AL), Detroit Tigers |
| Bill Skowron | April 13, 1954 | October 1, 1967 | First baseman | New York Yankees, Los Angeles Dodgers, Washington Senators (1961–1971), Chicago White Sox, California Angels |
| Matt Skrmetta | June 6, 2000 | September 27, 2000 | Pitcher | Montreal Expos, Pittsburgh Pirates |
| Bob Skube | September 17, 1982 | May 29, 1983 | Outfielder | Milwaukee Brewers |
| Gordon Slade | April 21, 1930 | September 10, 1935 | Shortstop | Brooklyn Robins/Dodgers, St. Louis Cardinals, Cincinnati Reds |
| Art Sladen | August 22, 1884 | August 25, 1884 | Outfielder | Boston Reds (UA) |
| Jimmy Slagle | April 17, 1899 | October 3, 1908 | Outfielder | Washington Senators (1891–99), Philadelphia Phillies, Boston Beaneaters, Chicago Orphans/Cubs |
| John Slagle | April 30, 1891 | April 30, 1891 | Pitcher | Cincinnati Kelly's Killers |
| Roger Slagle | September 7, 1979 | September 7, 1979 | Pitcher | New York Yankees |
| Walt Slagle | May 4, 1910 | May 4, 1910 | Pitcher | Cincinnati Reds |
| Anthony Slama | July 21, 2010 | | Pitcher | Minnesota Twins |
| Cy Slapnicka | September 26, 1911 | August 8, 1918 | Pitcher | Chicago Cubs, Pittsburgh Pirates |
| John Slappey | August 23, 1920 | October 2, 1920 | Pitcher | Philadelphia Athletics |
| Doug Slaten | September 4, 2006 | | Pitcher | Arizona Diamondbacks, Washington Nationals |
| Jim Slaton | April 14, 1971 | September 28, 1986 | Pitcher | Milwaukee Brewers, Detroit Tigers, California Angels |
| Jack Slattery | September 28, 1901 | September 29, 1909 | Catcher | Boston Red Sox, Cleveland Naps, Chicago White Stockings (AL), St. Louis Cardinals, Washington Senators |
| Mike Slattery | April 17, 1884 | July 23, 1891 | Outfielder | Boston Reds (UA), New York Giants, New York Giants (PL), Cincinnati Reds, Washington Statesmen |
| Phil Slattery | September 16, 1915 | September 25, 1915 | Pitcher | Pittsburgh Pirates |
| Don Slaught | July 6, 1982 | May 19, 1997 | Catcher | Kansas City Royals, Texas Rangers, New York Yankees, Pittsburgh Pirates, California Angels, Chicago White Sox, San Diego Padres |
| Barney Slaughter | August 9, 1910 | October 11, 1910 | Pitcher | Philadelphia Phillies |
| Enos Slaughter β | April 19, 1938 | September 29, 1959 | Outfielder | St. Louis Cardinals, New York Yankees, Kansas City Royals, Milwaukee Braves |
| Sterling Slaughter | April 19, 1964 | September 13, 1964 | Pitcher | Chicago Cubs |
| Bill Slayback | June 26, 1972 | October 2, 1974 | Pitcher | Detroit Tigers |
| Scottie Slayback | September 26, 1926 | September 26, 1926 | Second baseman | New York Giants |
| Steve Slayton | July 21, 1928 | July 28, 1928 | Pitcher | Boston Red Sox |
| Lou Sleater | April 25, 1950 | September 28, 1958 | Pitcher | St. Louis Browns, Washington Senators, Kansas City Athletics, Milwaukee Braves, Detroit Tigers, Baltimore Orioles |
| Terrmel Sledge | April 6, 2004 | | Outfielder | Montreal Expos/Washington Nationals, San Diego Padres |
| Bruce Sloan | April 29, 1944 | October 1, 1944 | Outfielder | New York Giants |
| Tod Sloan | September 22, 1913 | July 10, 1919 | Outfielder | St. Louis Browns |
| Lefty Sloat | April 24, 1948 | May 13, 1949 | Pitcher | Brooklyn Dodgers, Chicago Cubs |
| Brian Slocum | April 22, 2006 | | Pitcher | Cleveland Indians |
| Ron Slocum | September 8, 1969 | April 18, 1971 | Utility player | San Diego Padres |
| Heathcliff Slocumb | April 11, 1991 | September 26, 2000 | Pitcher | Chicago Cubs, Cleveland Indians, Philadelphia Phillies, Boston Red Sox, Seattle Mariners, Baltimore Orioles, St. Louis Cardinals, San Diego Padres |
| Kevin Slowey | June 1, 2007 | | Pitcher | Minnesota Twins |
| Joe Slusarski | April 11, 1991 | June 21, 2001 | Pitcher | Oakland Athletics, Milwaukee Brewers, Houston Astros, Atlanta Braves |
| Craig Smajstrla | September 6, 1988 | September 27, 1988 | Second baseman | Houston Astros |
| Aaron Small | June 11, 1994 | June 15, 2006 | Pitcher | New York Yankees |
| Charlie Small | July 7, 1930 | September 25, 1930 | Outfielder | Boston Red Sox |
| Hank Small | September 27, 1978 | September 27, 1978 | First baseman | Atlanta Braves |
| Jim Small | June 22, 1955 | September 27, 1958 | Outfielder | Detroit Tigers, Kansas City Athletics |
| Mark Small | April 5, 1996 | September 3, 1996 | Pitcher | Houston Astros |
| Roy Smalley Jr. | April 20, 1948 | April 21, 1958 | Shortstop | Chicago Cubs, Milwaukee Braves, Philadelphia Phillies |
| Roy Smalley III | April 30, 1975 | October 4, 1987 | Shortstop | Texas Rangers, Minnesota Twins, New York Yankees, Chicago White Sox |
| Will Smalley | April 19, 1890 | April 30, 1891 | Third baseman | Cleveland Spiders, Washington Statesmen |
| Walt Smallwood | September 19, 1917 | August 15, 1919 | Pitcher | New York Yankees |
| J. D. Smart | April 6, 1999 | June 30, 2001 | Pitcher | Montreal Expos, Texas Rangers |
| Joe Smaza | September 18, 1946 | September 21, 1946 | Outfielder | Chicago White Sox |
| Bill Smiley | October 13, 1874 | September 30, 1882 | Second baseman | Baltimore Canaries, St. Louis Brown Stockings (AA), Baltimore Orioles (19th century) |
| John Smiley | September 1, 1986 | August 30, 1997 | Pitcher | Pittsburgh Pirates, Minnesota Twins, Cincinnati Reds, Cleveland Indians |
| Smith, first name unknown (1884 P) | June 5, 1884 | June 5, 1884 | Pitcher | Baltimore Monumentals |
| Al Smith (RHP) | June 18, 1926 | June 18, 1926 | Pitcher | New York Giants |
| Al Smith (LHP) | May 5, 1934 | September 15, 1945 | Pitcher | New York Giants, Philadelphia Phillies, Cleveland Indians |
| Al Smith (OF) | July 10, 1953 | October 4, 1964 | Outfielder | Cleveland Indians, Chicago White Sox, Baltimore Orioles, Boston Red Sox |
| Aleck Smith | April 23, 1897 | October 5, 1906 | Catcher | Brooklyn Bridegrooms/Superbas, Baltimore Orioles (19th century), New York Giants, Baltimore Orioles (1901–02), Boston Red Sox, Chicago Cubs |
| Art Smith | June 9, 1932 | June 13, 1932 | Pitcher | Chicago White Sox |
| Bernie Smith | July 31, 1970 | April 28, 1971 | Outfielder | Milwaukee Brewers |
| Bill Smith (OF/C/Mgr) | April 14, 1873 | July 11, 1873 | Utility player | Baltimore Marylands |
| Bill Smith (OF) | September 17, 1884 | September 17, 1884 | Outfielder | Cleveland Blues (NL) |
| Billy Smith (RHP) | July 6, 1886 | September 13, 1886 | Pitcher | Detroit Wolverines |
| Bill Smith (LHP) | September 13, 1958 | September 28, 1962 | Pitcher | St. Louis Cardinals, Philadelphia Phillies |
| Billy Smith (2B) | April 13, 1975 | September 24, 1981 | Second baseman | California Angels, Baltimore Orioles, San Francisco Giants |
| Billy Smith (P) | June 9, 1981 | October 3, 1981 | Pitcher | Houston Astros |
| Bob Smith (RHP born 1890) | April 19, 1913 | April 19, 1915 | Pitcher | Chicago White Sox, Buffalo Buffeds/Blues |
| Bob Smith (RHP born 1895) | April 19, 1925 | August 7, 1937 | Pitcher | Boston Braves, Chicago Cubs, Cincinnati Reds, Boston Bees |
| Bob Smith (LHP born 1928) | April 22, 1958 | September 27, 1959 | Pitcher | Boston Red Sox, Chicago Cubs, Cleveland Indians |
| Bob Smith (LHP born 1931) | April 29, 1955 | September 23, 1959 | Pitcher | Boston Red Sox, St. Louis Cardinals, Pittsburgh Pirates, Detroit Tigers |
| Bob Smith | March 31, 1998 | May 6, 2002 | Third baseman | Tampa Bay Devil Rays |
| Bobby Smith | April 16, 1957 | July 17, 1965 | Outfielder | St. Louis Cardinals, Philadelphia Phillies, New York Mets, Chicago Cubs, California Angels |
| Brian Smith | September 11, 2000 | September 15, 2000 | Pitcher | Pittsburgh Pirates |
| Brick Smith | September 13, 1987 | April 23, 1988 | First baseman | Seattle Mariners |
| Bryn Smith | September 8, 1981 | June 1, 1993 | Pitcher | Montreal Expos, St. Louis Cardinals, Colorado Rockies |
| Bud Smith | June 10, 2001 | July 19, 2002 | Pitcher | St. Louis Cardinals |
| Bull Smith | August 30, 1904 | August 30, 1911 | Outfielder | Pittsburgh Pirates, Chicago Cubs, Washington Senators |
| Carr Smith | September 23, 1923 | June 9, 1924 | Outfielder | Washington Senators |
| Charley Smith | September 8, 1960 | April 22, 1969 | Third baseman | Los Angeles Dodgers, Philadelphia Phillies, Chicago White Sox, New York Mets, St. Louis Cardinals, New York Yankees, Chicago Cubs |
| Charlie Smith (3B) | May 18, 1871 | August 1, 1871 | Third baseman | New York Mutuals |
| Charlie Smith (P) | August 6, 1902 | September 19, 1914 | Pitcher | Cleveland Bronchos, Washington Senators, Boston Red Sox, Chicago Cubs |
| Chick Smith | April 12, 1913 | May 21, 1913 | Pitcher | Cincinnati Reds |
| Chris Smith (1B) | May 14, 1981 | October 2, 1983 | First baseman | Montreal Expos, San Francisco Giants |
| Chris Smith (P) | June 21, 2008 | | Pitcher | Boston Red Sox, Milwaukee Brewers |
| Chuck Smith | June 13, 2000 | July 24, 2001 | Pitcher | Florida Marlins |
| Clay Smith | September 13, 1938 | September 22, 1940 | Pitcher | Cleveland Indians, Detroit Tigers |
| D. Smith | September 15, 1875 | October 9, 1875 | Second baseman | Brooklyn Atlantics |
| Dan Smith (LHP) | September 12, 1992 | July 8, 1994 | Pitcher | Texas Rangers |
| Dan Smith (RHP) | June 8, 1999 | June 25, 2003 | Pitcher | Montreal Expos, Boston Red Sox |
| Daryl Smith | September 18, 1990 | October 3, 1990 | Pitcher | Kansas City Royals |
| Dave Smith (P, born 1914) | June 16, 1938 | April 23, 1939 | Pitcher | Philadelphia Athletics |
| Dave Smith (P, born 1955) | April 11, 1980 | June 8, 1992 | Pitcher | Houston Astros, Chicago Cubs |
| Dave Smith (P, born 1957) | September 18, 1984 | September 14, 1985 | Pitcher | California Angels |
| Dick Smith (3B) | September 14, 1951 | May 1, 1955 | Third baseman | Pittsburgh Pirates |
| Dick Smith (NL OF) | July 20, 1963 | May 2, 1965 | Outfielder | New York Mets, Los Angeles Dodgers |
| Dick Smith (AL OF) | August 20, 1969 | September 27, 1969 | Outfielder | Washington Senators (1961–1971) |
| Doug Smith | July 10, 1912 | July 10, 1912 | Pitcher | Boston Red Sox |
| Dwight Smith | May 1, 1989 | September 29, 1996 | Outfielder | Chicago Cubs, California Angels, Baltimore Orioles, Atlanta Braves |
| Earl Smith (1910s OF) | September 10, 1916 | August 6, 1922 | Outfielder | Chicago Cubs, St. Louis Browns, Washington Senators |
| Earl Smith (C) | April 24, 1919 | September 28, 1930 | Catcher | New York Giants, Boston Braves, Pittsburgh Pirates, St. Louis Cardinals |
| Earl Smith (1950s OF) | April 14, 1955 | April 29, 1955 | Outfielder | Pittsburgh Pirates |
| Ed Smith (1880s P) | April 18, 1884 | May 22, 1884 | Pitcher | Baltimore Monumentals |
| Ed Smith (1900s P) | April 27, 1906 | October 7, 1906 | Pitcher | St. Louis Browns |
| Eddie Smith | September 20, 1936 | September 20, 1947 | Pitcher | Philadelphia Athletics, Chicago White Sox, Boston Red Sox |
| Edgar Smith (OF) | June 20, 1883 | September 29, 1883 | Outfielder | Boston Beaneaters |
| Edgar Smith (P) | May 23, 1883 | August 12, 1918 | Pitcher | Philadelphia Quakers, Washington Nationals (AA), Providence Grays, Cleveland Spiders |
| Elmer Smith | September 20, 1914 | September 27, 1925 | Outfielder | Cleveland Naps/Indians, Washington Senators, Boston Red Sox, New York Yankees, Cincinnati Reds |
| Ernie Smith | April 17, 1930 | May 22, 1930 | Shortstop | Chicago White Sox |
| Frank Smith (C) | August 6, 1884 | October 3, 1884 | Catcher | Pittsburgh Alleghenys |
| Frank Smith (1900s P) | April 22, 1904 | September 30, 1915 | Pitcher | Chicago White Sox, Boston Red Sox, Cincinnati Reds, Baltimore Terrapins, Brooklyn Tip-Tops |
| Frank Smith (1950s P) | April 18, 1950 | May 13, 1956 | Pitcher | Cincinnati Reds/Redlegs, St. Louis Cardinals |
| Fred Smith (1890s P) | April 18, 1890 | October 12, 1890 | Pitcher | Toledo Maumees |
| Fred Smith (1900s P) | June 14, 1907 | September 21, 1907 | Pitcher | Cincinnati Reds |
| Fred Smith (IF) | April 17, 1913 | September 30, 1917 | Third baseman | Boston Braves, Buffalo Buffeds/Blues, Brooklyn Tip-Tops, St. Louis Cardinals |
| George Smith (NL P) | August 9, 1916 | September 21, 1923 | Second baseman | New York Giants, Cincinnati Reds, Brooklyn Robins, Philadelphia Phillies |
| George Smith (2B) | April 21, 1926 | September 17, 1930 | Pitcher | Detroit Tigers, Boston Red Sox |
| George Smith (AL P) | August 4, 1963 | September 17, 1966 | Pitcher | Detroit Tigers, Boston Red Sox |
| Germany Smith | April 17, 1884 | October 9, 1898 | Shortstop | Altoona Mountain City, Cleveland Blues, Brooklyn Grays/Bridegrooms, Cincinnati Reds, St. Louis Browns (NL) |
| Greg Smith (IF) | September 2, 1989 | May 24, 1991 | Second baseman | Chicago Cubs, Los Angeles Dodgers |
| Greg Smith (P) | April 9, 2008 | | Pitcher | Oakland Athletics, Colorado Rockies |
| Hal Smith (P) | September 14, 1932 | April 18, 1935 | Pitcher | Pittsburgh Pirates |
| Hal Smith (C/IF) | April 11, 1955 | July 22, 1964 | Catcher | Baltimore Orioles, Kansas City Athletics, Pittsburgh Pirates, Houston Colt .45s, Cincinnati Reds |
| Hal Smith (C) | May 2, 1956 | July 8, 1965 | Catcher | St. Louis Cardinals, Pittsburgh Pirates |
| Happy Smith | April 15, 1910 | July 22, 1910 | Outfielder | Brooklyn Superbas |
| Harry Smith (2B) | May 8, 1877 | August 19, 1889 | Second baseman | Chicago White Stockings, Cincinnati Reds (1876–1880), Louisville Colonels |
| Harry Smith (1900s C) | July 11, 1901 | September 15, 1910 | Catcher | Philadelphia Athletics, Pittsburgh Pirates, Boston Doves |
| Harry Smith (P) | October 6, 1912 | October 6, 1912 | Pitcher | Chicago White Sox |
| Harry Smith (1910s C) | September 21, 1914 | June 23, 1918 | Catcher | New York Giants, Brooklyn Tip-Tops, Cincinnati Reds |
| Harvey Smith | August 19, 1896 | September 26, 1896 | Third baseman | Washington Senators (1891–99) |
| Heinie Smith | September 8, 1897 | August 16, 1903 | Second baseman | Louisville Colonels, Pittsburgh Pirates, New York Giants, Detroit Tigers |
| Jack Smith (3B) | May 8, 1912 | May 8, 1912 | Third baseman | Detroit Tigers |
| Jack Smith (OF) | September 30, 1915 | July 7, 1929 | Outfielder | St. Louis Cardinals, Boston Braves |
| Jack Smith (P) | September 10, 1962 | June 21, 1964 | Pitcher | Los Angeles Dodgers, Milwaukee Braves |
| Jake Smith | October 3, 1911 | October 9, 1911 | Pitcher | Philadelphia Phillies |
| Jason Smith | June 17, 2001 | | Utility infielder | Chicago Cubs, Tampa Bay Devil Rays, Detroit Tigers, Colorado Rockies, Toronto Blue Jays, Arizona Diamondbacks, Kansas City Royals, Houston Astros |
| Jim Smith | April 12, 1982 | September 28, 1982 | Shortstop | Pittsburgh Pirates |
| Jimmy Smith | September 26, 1914 | September 3, 1922 | Utility infielder | Chicago Chi-Feds/Whales, Baltimore Terrapins, Pittsburgh Pirates, New York Giants, Boston Braves, Cincinnati Reds, Philadelphia Phillies |
| Joe Smith (C) | July 7, 1913 | September 27, 1913 | Catcher | New York Yankees |
| Joe Smith (P) | April 1, 2007 | | Pitcher | New York Mets, Cleveland Indians |
| John Smith (SS) | April 14, 1873 | May 21, 1875 | Shortstop | Baltimore Marylands, Baltimore Canaries, New Haven Elm Citys |
| John Smith (NL 1B) | May 1, 1882 | September 27, 1882 | First baseman | Troy Trojans, Worcester Ruby Legs |
| John Smith (AL 1B) | September 17, 1931 | September 18, 1931 | First baseman | Boston Red Sox |
| Jordan Smith | June 15, 2010 | | Pitcher | Cincinnati Reds |
| Jud Smith | May 21, 1893 | September 15, 1901 | Third baseman | Cincinnati Reds, St. Louis Cardinals, Pittsburgh Pirates, Washington Senators (1891–99) |
| Keith Smith (OF) | August 2, 1977 | October 5, 1980 | Outfielder | Texas Rangers, St. Louis Cardinals |
| Keith Smith (SS) | April 12, 1984 | October 5, 1985 | Shortstop | New York Yankees |
| Ken Smith | September 22, 1981 | June 14, 1983 | First baseman | Atlanta Braves |
| Klondike Smith | September 28, 1912 | October 5, 1912 | Outfielder | New York Yankees |
| Lee Smith | September 1, 1980 | July 2, 1997 | Pitcher | Chicago Cubs, Boston Red Sox, St. Louis Cardinals, New York Yankees, Baltimore Orioles, California Angels, Cincinnati Reds, Montreal Expos |
| Leo Smith | August 28, 1890 | October 15, 1890 | Shortstop | Rochester Broncos |
| Lewis Smith | September 7, 1882 | September 7, 1882 | Outfielder | Baltimore Orioles (19th century) |
| Lonnie Smith | September 2, 1978 | August 10, 1994 | Outfielder | Philadelphia Phillies, St. Louis Cardinals, Kansas City Royals, Atlanta Braves, Pittsburgh Pirates, Baltimore Orioles |
| Mark Smith (P) | August 12, 1983 | October 2, 1983 | Pitcher | Oakland Athletics |
| Mark Smith (OF) | May 14, 1993 | September 28, 2003 | Outfielder | Baltimore Orioles, Pittsburgh Pirates, Florida Marlins, Montreal Expos, Milwaukee Brewers |
| Matt Smith | April 14, 2006 | April 25, 2007 | Pitcher | New York Yankees, Philadelphia Phillies |
| Mayo Smith | June 24, 1945 | September 27, 1945 | Outfielder | Philadelphia Athletics |
| Mike Smith (1890s OF) | September 10, 1886 | June 15, 1901 | Outfielder | Cincinnati Red Stockings (AA), Pittsburgh Pirates, Cincinnati Reds, New York Giants, Boston Beaneaters |
| Mike Smith (1920s OF) | September 4, 1926 | September 20, 1926 | Outfielder | New York Giants |
| Mike Smith (1984–89 P) | April 6, 1984 | September 30, 1989 | Pitcher | Cincinnati Reds, Montreal Expos, Pittsburgh Pirates |
| Mike Smith (1989–90 P) | June 30, 1989 | September 30, 1990 | Pitcher | Baltimore Orioles |
| Mike Smith (2000s P) | April 26, 2002 | August 6, 2006 | Pitcher | Toronto Blue Jays, Minnesota Twins |
| Milt Smith | July 21, 1955 | September 25, 1955 | Third baseman | Cincinnati Redlegs |
| Nate Smith | September 19, 1962 | September 29, 1962 | Catcher | Baltimore Orioles |
| Ollie Smith | July 11, 1894 | August 25, 1894 | Outfielder | Louisville Colonels |
| Ozzie Smith β | April 7, 1978 | September 29, 1996 | Shortstop | San Diego Padres, St. Louis Cardinals |
| Paddy Smith | July 6, 1920 | July 7, 1920 | Catcher | Boston Red Sox |
| Paul Smith (OF) | September 19, 1916 | October 1, 1916 | Outfielder | Cincinnati Reds |
| Paul Smith (1B) | April 14, 1953 | June 7, 1958 | First baseman | Pittsburgh Pirates, Chicago Cubs |
| Pete Smith (1962–63 P) | September 13, 1962 | September 28, 1963 | Pitcher | Boston Red Sox |
| Pete Smith (1987–98 P) | September 8, 1987 | September 24, 1998 | Pitcher | Atlanta Braves, New York Mets, Cincinnati Reds, San Diego Padres, Baltimore Orioles |
| Phenomenal Smith | April 18, 1884 | June 15, 1891 | Pitcher | Philadelphia Athletics (AA), Pittsburgh Alleghenys, Brooklyn Grays, Detroit Wolverines, Baltimore Orioles (19th century), Philadelphia Phillies |
| Pop Smith | May 1, 1880 | June 9, 1891 | Second baseman | Cincinnati Reds (1876–1880), Cleveland Blues (NL), Buffalo Bisons, Worcester Ruby Legs, Philadelphia Athletics (AA), Louisville Eclipse, Columbus Buckeyes, Pittsburgh Alleghenys, Boston Beaneaters, Washington Statesmen |
| Pop-Boy Smith | April 19, 1913 | May 2, 1917 | Pitcher | Chicago White Sox, Cleveland Indians |
| Ray Smith | April 9, 1981 | September 21, 1983 | Catcher | Minnesota Twins |
| Red Smith (3B) | September 5, 1911 | September 25, 1919 | Third baseman | Brooklyn Dodgers/Superbas/Robins, Boston Braves |
| Red Smith (1910s C) | September 17, 1917 | September 1, 1918 | Catcher | Pittsburgh Pirates |
| Red Smith (SS) | April 14, 1925 | September 26, 1925 | Shortstop | Philadelphia Athletics |
| Red Smith (1920s C) | May 31, 1927 | May 31, 1927 | Catcher | New York Giants |
| Reggie Smith | September 18, 1966 | October 3, 1982 | Outfielder | Boston Red Sox, St. Louis Cardinals, Los Angeles Dodgers, San Francisco Giants |
| Rex Smith | May 31, 1886 | July 11, 1886 | Pitcher | Cincinnati Reds, Philadelphia Athletics (AA) |
| Roy Smith (1980s P) | June 23, 1984 | August 16, 1991 | Pitcher | Cleveland Indians, Minnesota Twins, Baltimore Orioles |
| Roy Smith (2000s P) | May 26, 2001 | September 29, 2002 | Pitcher | Cleveland Indians |
| Rufus Smith | October 2, 1927 | October 2, 1927 | Pitcher | Detroit Tigers |
| Seth Smith | September 16, 2007 | | Outfielder | Colorado Rockies |
| Sherry Smith | May 11, 1911 | July 18, 1927 | Pitcher | Pittsburgh Pirates, Brooklyn Robins, Cleveland Indians |
| Skyrocket Smith | April 18, 1888 | July 2, 1888 | First baseman | Louisville Colonels |
| Stub Smith | September 10, 1898 | October 15, 1898 | Shortstop | Boston Beaneaters |
| Syd Smith | April 14, 1908 | April 18, 1915 | Catcher | Philadelphia Athletics, St. Louis Browns, Cleveland Naps, Pittsburgh Pirates |
| Tom Smith (P) | June 6, 1894 | May 12, 1898 | Pitcher | Boston Beaneaters, Philadelphia Phillies, Louisville Colonels, St. Louis Cardinals |
| Tommy Smith | September 6, 1973 | September 10, 1977 | Outfielder | Cleveland Indians, Seattle Mariners |
| Tony Smith | August 12, 1907 | July 11, 1911 | Shortstop | Washington Senators, Brooklyn Superbas/Dodgers |
| Travis Smith | June 21, 1998 | May 20, 2006 | Pitcher | Milwaukee Brewers, St. Louis Cardinals, Atlanta Braves, Florida Marlins |
| Vinnie Smith | September 10, 1941 | April 27, 1946 | Catcher | Pittsburgh Pirates |
| Wally Smith | April 17, 1911 | October 7, 1914 | Utility infielder | St. Louis Cardinals, Washington Senators |
| Wib Smith | May 31, 1909 | September 29, 1909 | Catcher | St. Louis Browns |
| Willie Smith (OF) | June 18, 1963 | September 30, 1971 | Outfielder | Detroit Tigers, Los Angeles/California Angels, Cleveland Indians, Chicago Cubs, Cincinnati Reds |
| Willie Smith (P) | April 25, 1994 | May 10, 1994 | Pitcher | St. Louis Cardinals |
| Zane Smith | September 10, 1984 | July 5, 1996 | Pitcher | Atlanta Braves, Montreal Expos, Pittsburgh Pirates, Boston Red Sox |
| Roger Smithberg | September 1, 1993 | July 2, 1994 | Pitcher | Oakland Athletics |
| Stephen Smitherman | July 1, 2003 | September 25, 2003 | Outfielder | Cincinnati Reds |
| Mike Smithson | August 27, 1982 | September 28, 1989 | Pitcher | Texas Rangers, Minnesota Twins, Boston Red Sox |
| Justin Smoak | April 23, 2010 | | First baseman | Texas Rangers, Seattle Mariners |
| Lefty Smoll | April 26, 1940 | September 12, 1940 | Pitcher | Philadelphia Phillies |
| John Smoltz | July 23, 1988 | | Pitcher | Atlanta Braves, Boston Red Sox, St. Louis Cardinals |
| Homer Smoot | April 17, 1902 | October 7, 1906 | Center fielder | St. Louis Cardinals, Cincinnati Reds |
| Henry Smoyer | August 14, 1912 | September 7, 1912 | Shortstop | St. Louis Browns |
| Frank Smykal | August 30, 1916 | September 10, 1916 | Shortstop | Pittsburgh Pirates |
| Clancy Smyres | April 18, 1944 | April 30, 1944 | Pinch hitter | Brooklyn Dodgers |
| Red Smyth | August 11, 1915 | June 18, 1918 | Outfielder | Brooklyn Robins, St. Louis Cardinals |
| Steve Smyth | August 6, 2002 | September 27, 2002 | Pitcher | Chicago Cubs |
| Harry Smythe | July 21, 1929 | June 26, 1934 | Pitcher | Philadelphia Phillies, New York Yankees, Brooklyn Dodgers |
| Ryan Snare | August 6, 2004 | August 6, 2004 | Pitcher | Texas Rangers |
| Esix Snead | September 3, 2002 | May 21, 2004 | Outfielder | New York Mets |
| John Sneed | May 1, 1884 | September 22, 1891 | Outfielder | Indianapolis Hoosiers (AA), Toledo Maumees, Columbus Solons |
| Charlie Snell | July 19, 1912 | August 14, 1912 | Catcher | St. Louis Browns |
| Ian Snell | August 20, 2004 | | Pitcher | Pittsburgh Pirates, Seattle Mariners |
| Nate Snell | September 20, 1984 | September 29, 1987 | Pitcher | Baltimore Orioles, Detroit Tigers |
| Wally Snell | August 1, 1913 | October 4, 1913 | Catcher | Boston Red Sox |
| Chris Snelling | May 25, 2002 | | Outfielder | Seattle Mariners, Washington Nationals, Oakland Athletics, Philadelphia Phillies |
| Duke Snider β | April 17, 1947 | October 3, 1964 | Outfielder | Brooklyn Dodgers, Los Angeles Dodgers, New York Mets, San Francisco Giants |
| Travis Snider | August 29, 2008 | | Outfielder | Toronto Blue Jays |
| Van Snider | September 2, 1988 | July 29, 1989 | Outfielder | Cincinnati Reds |
| Roxy Snipes | July 15, 1923 | July 15, 1923 | Pinch hitter | Chicago White Sox |
| Chappie Snodgrass | May 15, 1901 | May 16, 1901 | Outfielder | Baltimore Orioles (1901–02) |
| Fred Snodgrass | June 4, 1908 | October 5, 1916 | Outfielder | New York Giants, Boston Braves |
| Frank Snook | July 13, 1973 | September 29, 1973 | Pitcher | San Diego Padres |
| Chris Snopek | July 31, 1995 | September 27, 1998 | Third baseman | Chicago White Sox, Boston Red Sox |
| Colonel Snover | September 18, 1919 | September 25, 1919 | Pitcher | New York Giants |
| Charlie Snow | October 1, 1874 | October 1, 1874 | Catcher | Brooklyn Atlantics |
| J. T. Snow | September 20, 1992 | June 18, 2006 | First baseman | New York Yankees, California Angels, San Francisco Giants, Boston Red Sox |
| Bernie Snyder | September 15, 1935 | September 29, 1935 | Utility infielder | Philadelphia Athletics |
| Bill Snyder | September 4, 1919 | July 20, 1920 | Pitcher | Washington Senators |
| Brad Snyder | September 7, 2010 | | Outfielder | Chicago Cubs |
| Brandon Snyder | September 10, 2010 | | First baseman | Baltimore Orioles |
| Brian Snyder | May 25, 1985 | June 27, 1989 | Pitcher | Seattle Mariners, Oakland Athletics |
| Charles Snyder | September 19, 1890 | October 8, 1890 | Utility player | Philadelphia Athletics (AA) |
| Chris Snyder | August 21, 2004 | | Catcher | Arizona Diamondbacks, Pittsburgh Pirates |
| Cooney Snyder | May 19, 1898 | June 19, 1898 | Catcher | Louisville Colonels |
| Cory Snyder | June 13, 1986 | August 10, 1994 | Outfielder | Cleveland Indians, Chicago White Sox, Toronto Blue Jays, San Francisco Giants, Los Angeles Dodgers |
| Earl Snyder | April 28, 2002 | August 18, 2004 | First baseman | Cleveland Indians, Boston Red Sox |
| Frank Snyder | August 25, 1912 | September 29, 1927 | Catcher | St. Louis Cardinals, New York Giants |
| Gene Snyder | April 26, 1959 | July 14, 1959 | Pitcher | Los Angeles Dodgers |
| George Snyder | September 30, 1882 | September 30, 1882 | Pitcher | Philadelphia Athletics (AA) |
| Jack Snyder | June 13, 1914 | October 4, 1917 | Catcher | Buffalo Buffeds, Brooklyn Robins |
| Jerry Snyder | May 8, 1952 | May 10, 1958 | Shortstop | Washington Senators |
| Jim Snyder (SS) | May 7, 1872 | October 5, 1872 | Shortstop | Eckford of Brooklyn |
| Jim Snyder (2B) | September 15, 1961 | August 2, 1964 | Second baseman | Minnesota Twins |
| John Snyder | June 30, 1998 | September 23, 2000 | Pitcher | Chicago White Sox, Milwaukee Brewers |
| Josh Snyder | May 18, 1872 | July 9, 1872 | Outfielder | Eckford of Brooklyn |
| Kyle Snyder | May 1, 2003 | | Pitcher | Kansas City Royals, Boston Red Sox |
| Pop Snyder | June 16, 1873 | July 4, 1891 | Catcher | Washington Blue Legs, Baltimore Canaries, Philadelphia White Stockings, Louisville Grays, Boston Red Caps, Cincinnati Red Stockings (AA), Cleveland Blues (AA), Cleveland Spiders, Cleveland Infants, Washington Statesmen |
| Redleg Snyder | April 25, 1876 | September 12, 1884 | Outfielder | Cincinnati Reds (1876–1880), Wilmington Quicksteps |
| Russ Snyder | April 18, 1959 | September 30, 1970 | Outfielder | Kansas City Athletics, Baltimore Orioles, Chicago White Sox, Cleveland Indians, Milwaukee Brewers |
| Scott Sobkowiak | October 7, 2001 | October 7, 2001 | Pitcher | Atlanta Braves |
| Chief Sockalexis | April 22, 1897 | May 13, 1899 | Outfielder | Cleveland Spiders |
| Bill Sodd | September 27, 1937 | September 27, 1937 | Pinch hitter | Cleveland Indians |
| Eric Soderholm | September 3, 1971 | October 5, 1980 | Third baseman | Minnesota Twins, Chicago White Sox, Texas Rangers |
| Steve Soderstrom | September 17, 1996 | September 27, 1996 | Pitcher | San Francisco Giants |
| Clint Sodowsky | September 4, 1995 | May 22, 1999 | Pitcher | Detroit Tigers, Pittsburgh Pirates, Arizona Diamondbacks, St. Louis Cardinals |
| Ray Soff | July 17, 1986 | May 28, 1987 | Pitcher | St. Louis Cardinals |
| Rick Sofield | April 6, 1979 | October 4, 1981 | Outfielder | Minnesota Twins |
| Eric Sogard | September 14, 2010 | | Infielder | Oakland Athletics |
| Luis Sojo | July 14, 1990 | September 28, 2003 | Utility infielder | Toronto Blue Jays, California Angels, Seattle Mariners, New York Yankees, Pittsburgh Pirates |
| Tony Solaita | September 16, 1968 | September 30, 1979 | First baseman | New York Yankees, Kansas City Royals, California Angels, Montreal Expos, Toronto Blue Jays |
| Julio Solano | April 5, 1983 | April 30, 1989 | Pitcher | Houston Astros, Seattle Mariners |
| Alay Soler | May 24, 2006 | July 2, 2006 | Pitcher | New York Mets |
| Marcelino Solis | July 16, 1958 | September 13, 1958 | Pitcher | Chicago Cubs |
| Eddie Solomon | September 2, 1973 | July 1, 1982 | Pitcher | Los Angeles Dodgers, Chicago Cubs, St. Louis Cardinals, Atlanta Braves, Pittsburgh Pirates, Chicago White Sox |
| Mose Solomon | September 30, 1923 | October 7, 1923 | Outfielder | New York Giants |
| Moose Solters | April 17, 1934 | September 26, 1943 | Outfielder | Boston Red Sox, St. Louis Browns, Cleveland Indians, Chicago White Sox |
| Jock Somerlott | September 19, 1910 | May 25, 1911 | First baseman | Washington Senators |
| Ed Somerville | April 21, 1875 | October 5, 1876 | Second baseman | Philadelphia Centennials, New Haven Elm Citys, Louisville Grays |
| Joe Sommer | July 8, 1880 | October 15, 1890 | Outfielder | Cincinnati Reds (1876–1880), Cincinnati Red Stockings (AA), Baltimore Orioles (19th century), Cleveland Spiders |
| Andy Sommers | April 27, 1887 | October 4, 1890 | Catcher | New York Metropolitans, Boston Beaneaters, Chicago White Stockings, Indianapolis Hoosiers (NL), New York Giants, Cleveland Spiders |
| Bill Sommers | April 25, 1950 | October 1, 1950 | Third baseman | St. Louis Browns |
| Rudy Sommers | September 8, 1912 | July 13, 1927 | Pitcher | Chicago Cubs, Brooklyn Tip-Tops, Boston Red Sox |
| Andy Sommerville | August 8, 1894 | August 8, 1894 | Pitcher | Brooklyn Grooms |
| Don Songer | September 21, 1924 | August 5, 1927 | Pitcher | Pittsburgh Pirates, New York Giants |
| Andy Sonnanstine | June 5, 2007 | | Pitcher | Tampa Bay Devil Rays/Rays |
| Lary Sorensen | June 7, 1977 | September 24, 1988 | Pitcher | Milwaukee Brewers, St. Louis Cardinals, Cleveland Indians, Oakland Athletics, Chicago Cubs, Montreal Expos, San Francisco Giants |
| Zach Sorensen | June 3, 2003 | October 2, 2005 | Second baseman | Cleveland Indians, Los Angeles Angels of Anaheim |
| Joakim Soria | April 4, 2007 | | Pitcher | Kansas City Royals |
| Alfonso Soriano | September 14, 1999 | | Second baseman | New York Yankees, Texas Rangers, Washington Nationals, Chicago Cubs |
| Rafael Soriano | May 10, 2002 | | Pitcher | Seattle Mariners, Atlanta Braves, Tampa Bay Rays, New York Yankees |
| Billy Sorrell | September 2, 1965 | October 1, 1970 | Third baseman | Philadelphia Phillies, San Francisco Giants, Kansas City Royals |
| Vic Sorrell | April 22, 1928 | June 3, 1937 | Pitcher | Detroit Tigers |
| Chick Sorrells | September 18, 1922 | September 21, 1922 | Shortstop | Cleveland Indians |
| Paul Sorrento | September 8, 1989 | October 2, 1999 | First baseman | Minnesota Twins, Cleveland Indians, Seattle Mariners, Tampa Bay Devil Rays |
| Elías Sosa | September 8, 1972 | September 18, 1983 | Pitcher | San Francisco Giants, St. Louis Cardinals, Atlanta Braves, Los Angeles Dodgers, Oakland Athletics, Montreal Expos, Detroit Tigers, San Diego Padres |
| Henry Sosa | August 10, 2011 | | Pitcher | Houston Astros |
| Jorge Sosa | April 4, 2002 | | Pitcher | Tampa Bay Devil Rays, Atlanta Braves, St. Louis Cardinals, New York Mets, Washington Nationals, Florida Marlins |
| José Sosa | July 22, 1975 | September 26, 1976 | Pitcher | Houston Astros |
| Juan Sosa | September 10, 1999 | May 25, 2001 | Outfielder | Colorado Rockies, Arizona Diamondbacks |
| Sammy Sosa | June 16, 1989 | September 29, 2007 | Outfielder | Texas Rangers, Chicago White Sox, Chicago Cubs, Baltimore Orioles |
| Denny Sothern | September 10, 1926 | September 21, 1931 | Outfielder | Philadelphia Phillies, Pittsburgh Pirates, Brooklyn Dodgers |
| Allen Sothoron | September 17, 1914 | September 6, 1926 | Pitcher | St. Louis Browns, Boston Red Sox, Cleveland Indians, St. Louis Cardinals |
| Geovany Soto | September 23, 2005 | | Catcher | Chicago Cubs |
| Mario Soto | July 21, 1977 | June 16, 1988 | Pitcher | Cincinnati Reds |
| Steve Souchock | May 25, 1946 | April 15, 1955 | Outfielder | New York Yankees, Chicago White Sox, Detroit Tigers |
| Clyde Southwick | April 22, 1911 | September 9, 1911 | Catcher | St. Louis Browns |
| Bill Southworth | October 2, 1964 | October 4, 1964 | Third baseman | Milwaukee Braves |
| Billy Southworth β | August 4, 1913 | July 9, 1929 | Outfielder | Cleveland Naps/Indians, Pittsburgh Pirates, Boston Braves, New York Giants, St. Louis Cardinals |
| Mark Souza | April 22, 1980 | May 18, 1980 | Pitcher | Oakland Athletics |
| Bill Sowders | April 24, 1888 | June 19, 1890 | Pitcher | Boston Beaneaters, Pittsburgh Alleghenys |
| John Sowders | June 28, 1887 | October 4, 1890 | Pitcher | Indianapolis Hoosiers (NL), Kansas City Cowboys (AA), Brooklyn Ward's Wonders |
| Len Sowders | September 10, 1886 | October 14, 1886 | Outfielder | Baltimore Orioles (19th century) |
| Jeremy Sowers | June 25, 2006 | | Pitcher | Cleveland Indians |