# List of Dutch Top 40 number-one singles of 1988

These hits topped the Dutch Top 40 in 1988.
| Issue Date | Song | Artist(s) | Reference |
| 2 January | No Top 40 released | No Top 40 released | No Top 40 released |
| 9 January | "China in Your Hand" | T'Pau | |
| 16 January | "China in Your Hand" | T'Pau | |
| 23 January | "(I've Had) The Time of My Life" | Bill Medley & Jennifer Warnes | |
| 30 January | "(I've Had) The Time of My Life" | Bill Medley & Jennifer Warnes | |
| 6 February | "(I've Had) The Time of My Life" | Bill Medley & Jennifer Warnes | |
| 13 February | "(I've Had) The Time of My Life" | Bill Medley & Jennifer Warnes | |
| 20 February | "(I've Had) The Time of My Life" | Bill Medley & Jennifer Warnes | |
| 27 February | "(I've Had) The Time of My Life" | Bill Medley & Jennifer Warnes | |
| 5 March | "(I've Had) The Time of My Life" | Bill Medley & Jennifer Warnes | |
| 12 March | "(I've Had) The Time of My Life" | Bill Medley & Jennifer Warnes | |
| 19 March | "(I've Had) The Time of My Life" | Bill Medley & Jennifer Warnes | |
| 26 March | "Get Outta My Dreams, Get into My Car" | Billy Ocean | |
| 2 April | "Tell It to My Heart" | Taylor Dayne | |
| 9 April | "Gimme Hope Jo'anna" | Eddy Grant | |
| 16 April | "Gimme Hope Jo'anna" | Eddy Grant | |
| 23 April | "Gimme Hope Jo'anna" | Eddy Grant | |
| 30 April | "Gimme Hope Jo'anna" | Eddy Grant | |
| 7 May | "Gimme Hope Jo'anna" | Eddy Grant | |
| 14 May | "Yé ké yé ké" | Mory Kanté | |
| 21 May | "Yé ké yé ké" | Mory Kanté | |
| 28 May | "Nothing's Gonna Change My Love for You" | Glenn Medeiros | |
| 4 June | "Nothing's Gonna Change My Love for You" | Glenn Medeiros | |
| 11 June | "Nothing's Gonna Change My Love for You" | Glenn Medeiros | |
| 18 June | "Nothing's Gonna Change My Love for You" | Glenn Medeiros | |
| 25 June | "Nothing's Gonna Change My Love for You" | Glenn Medeiros | |
| 2 July | "Nothing's Gonna Change My Love for You" | Glenn Medeiros | |
| 9 July | "Fast Car" | Tracy Chapman | |
| 16 July | "Fast Car" | Tracy Chapman | |
| 23 July | "Push It" | Salt-n-Pepa | |
| 30 July | "Push It" | Salt-n-Pepa | |
| 6 August | "Push It" | Salt-n-Pepa | |
| 13 August | "Tribute (Right On)" | The Pasadenas | |
| 20 August | "Tribute (Right On)" | The Pasadenas | |
| 27 August | "Tribute (Right On)" | The Pasadenas | |
| 3 September | "Tribute (Right On)" | The Pasadenas | |
| 10 September | "Stop!" | Sam Brown | |
| 17 September | "Stop!" | Sam Brown | |
| 24 September | "Stop!" | Sam Brown | |
| 1 October | "The Only Way Is Up" | Yazz & the Plastic Population | |
| 8 October | "The Only Way Is Up" | Yazz & the Plastic Population | |
| 15 October | "A Groovy Kind of Love" | Phil Collins | |
| 22 October | "Teardrops" | Womack & Womack | |
| 29 October | "Teardrops" | Womack & Womack | |
| 5 November | "Teardrops" | Womack & Womack | |
| 12 November | "Teardrops" | Womack & Womack | |
| 19 November | "Teardrops" | Womack & Womack | |
| 26 November | "Teardrops" | Womack & Womack | |
| 3 December | "Orinoco Flow (Sail Away)" | Enya | |
| 10 December | "Orinoco Flow (Sail Away)" | Enya | |
| 17 December | "Orinoco Flow (Sail Away)" | Enya | |
| 24 December | "Smooth Criminal" | Michael Jackson | |
| 31 December | No Top 40 released | No Top 40 released | No Top 40 released |