# 2021 Wiesbaden Tennis Open – Singles

Barbora Krejčíková was the defending champion but chose not to participate.
Anna Bondár won the title, defeating Clara Burel in the final, 6–2, 6–4.

## Seeds

* Clara Burel (final)
* Cristina Bucșa (first round)
* Anna Bondár (champion)
* Marina Melnikova (second round)
* Réka Luca Jani (first round)
* Giulia Gatto-Monticone (second round)
* Lucrezia Stefanini (quarterfinals)
* Federica Di Sarra (quarterfinals, retired)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| 1 | Clara Burel | 4 | 6 | 6 | | | | |
| Q | Lina Gjorcheska | 6 | 4 | 4 | | | | |
| Q | Lina Gjorcheska | 6 | 4 | 4 | 1 | Clara Burel | 2 | 4 |
| | | | | | 3 | Anna Bondár | 6 | 6 |
| 3 | Anna Bondár | 6 | 6 | | 3 | Anna Bondár | 6 | 6 |
| | Conny Perrin | 2 | 3 | | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | C Burel | 7$^7$ | 6 | | | | | | | | | | | | | | | |
| Q | K Bartone | 6$^3$ | 2 | | 1 | C Burel | 6 | 6$^4$ | 6 | | | | | | | | | |
| Q | L Papadakis | 6 | 6 | | Q | L Papadakis | 2 | 7$^7$ | 0 | | | | | | | | | |
| WC | LI Putz | 2 | 0 | | | | | | | 1 | C Burel | 7$^7$ | 6 | | | | | |
| | A Ignatik | 6 | 6 | | | | | | | | A Ignatik | 6$^2$ | 4 | | | | | |
| | T Mrdeža | 3 | 1 | | | A Ignatik | 6 | 6 | | | | | | | | | | |
| | M Di Giuseppe | 7$^7$ | 7$^7$ | | | M Di Giuseppe | 2 | 3 | | | | | | | | | | |
| 5 | RL Jani | 6$^3$ | 6$^4$ | | | | | | | | | | | 1 | C Burel | 4 | 6 | 6 |
| 4 | M Melnikova | 7 | 6 | | | | | | | | | | | Q | L Gjorcheska | 6 | 4 | 4 |
| | A Zaja | 5 | 1 | | 4 | M Melnikova | 3 | 5 | | | | | | | | | | |
| | B Turati | 6$^3$ | 7 | 6$^5$ | Q | L Gjorcheska | 6 | 7 | | | | | | | | | | |
| Q | L Gjorcheska | 7$^7$ | 5 | 7$^7$ | | | | | | Q | L Gjorcheska | 6 | 2 | | | | | |
| LL | Y Morderger | 7$^7$ | 1 | 3 | | | | | | 8 | F Di Sarra | 1 | 0$^r$ | | | | | |
| WC | A Klasen | 6$^4$ | 6 | 6 | WC | A Klasen | 4 | 5 | | | | | | | | | | |
| | T Lukas | 3 | 2 | | 8 | F Di Sarra | 6 | 7 | | | | | | | | | | |
| 8 | F Di Sarra | 6 | 6 | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 7 | L Stefanini | 2 | 6 | 6 | | | | | | | | | | | | | |
| Q | N Berberović | 6 | 4 | 1 | 7 | L Stefanini | 6 | 6$^4$ | 6 | | | | | | | | |
| WC | K Kanev | 3 | 0 | | Q | S Wagner | 1 | 7$^7$ | 1 | | | | | | | | |
| Q | S Wagner | 6 | 6 | | | | | | | 7 | L Stefanini | 3 | 3 | | | | |
| | S Bandecchi | 6$^5$ | 6 | 4 | | | | | | 3 | A Bondár | 6 | 6 | | | | |
| JE | V Jiménez Kasintseva | 7$^7$ | 4 | 6 | JE | V Jiménez Kasintseva | 2 | 2$^r$ | | | | | | | | | |
| Q | C Ferrando | 0$^r$ | | | 3 | A Bondár | 6 | 3 | | | | | | | | | |
| 3 | A Bondár | 5 | | | | | | | | | | | | 3 | A Bondár | 6 | 6 |
| 6 | G Gatto-Monticone | 2 | 6 | 6 | | | | | | | | | | | C Perrin | 2 | 3 |
| Q | A Hartono | 6 | 1 | 2 | 6 | G Gatto-Monticone | 0 | 0 | | | | | | | | | |
| | C Perrin | 6 | 6 | | | C Perrin | 6 | 6 | | | | | | | | | |
| Q | A Roșca | 4 | 1 | | | | | | | | C Perrin | 6 | 6 | | | | |
| WC | M Hodzic | 1 | 2 | | | | | | | | Y In-Albon | 1 | 3 | | | | |
| | K Gerlach | 6 | 6 | | | K Gerlach | 2 | 4 | | | | | | | | | |
| | Y In-Albon | 6 | 7 | | | Y In-Albon | 6 | 6 | | | | | | | | | |
| 2 | C Bucșa | 4 | 5 | | | | | | | | | | | | | | |