# 2022 Guanajuato Open – Singles

Zhu Lin won the title, defeating Rebecca Marino in the final, 6–4, 6–1.
Astra Sharma was the defending champion having won the event when it was last held in 2019, but chose to participate at the BNP Paribas Open, where she reached the second round as a lucky loser.

## Seeds

* Zhu Lin (champion)
* Rebecca Marino (final)
* Anastasia Gasanova (withdrew)
* Arianne Hartono (second round)
* Robin Anderson (second round)
* Mirjam Björklund (withdrew)
* Valentini Grammatikopoulou (second round)
* Jamie Loeb (quarterfinals)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| 1 | Zhu Lin | 6 | 6 | | | | |
| | Anastasia Tikhonova | 2 | 0 | | | | |
| | Anastasia Tikhonova | 2 | 0 | 1 | Zhu Lin | 6 | 6 |
| | | | | 2 | Rebecca Marino | 4 | 1 |
| | Carolina Alves | 5 | 1 | 2 | Rebecca Marino | 4 | 1 |
| 2 | Rebecca Marino | 7 | 6 | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | L Zhu | 6 | 6 | | | | | | | | | | | | | | | |
| Q | AP Martínez Mora | 0 | 0 | | 1 | L Zhu | 6 | 6 | | | | | | | | | | |
| | D Vismane | 4 | 1 | | | Q Gleason | 1 | 4 | | | | | | | | | | |
| | Q Gleason | 6 | 6 | | | | | | | 1 | L Zhu | 6$^5$ | 6 | 6 | | | | |
| Q | E Oosterhout | 3 | 6$^5$ | | | | | | | 8 | J Loeb | 7$^7$ | 2 | 3 | | | | |
| | K Volodko | 6 | 7$^7$ | | | K Volodko | 4 | 7$^7$ | 4 | | | | | | | | | |
| | L Glushko | 3 | 3 | | 8 | J Loeb | 6 | 6$^4$ | 6 | | | | | | | | | |
| 8 | J Loeb | 6 | 6 | | | | | | | | | | | | 1 | L Zhu | 6 | 6 |
| LL | AM Becerra | 6 | 6$^1$ | 6$^3$ | | | | | | | | | | | | A Tikhonova | 2 | 0 |
| WC | G Arangio | 4 | 7$^7$ | 7$^7$ | WC | G Arangio | 1 | 1 | | | | | | | | | | |
| | A Tikhonova | 7$^7$ | 1 | 6 | | A Tikhonova | 6 | 6 | | | | | | | | | | |
| | F Contreras | 6$^4$ | 6 | 2 | | | | | | | A Tikhonova | 6 | 6 | | | | | |
| Q | D Hewitt | 2 | 7$^7$ | 6 | | | | | | Q | D Hewitt | 2 | 3 | | | | | |
| | M Zacarías | 6 | 6$^4$ | 4 | Q | D Hewitt | 6 | 4 | 6 | | | | | | | | | |
| | F Di Lorenzo | 6 | 6 | | | F Di Lorenzo | 3 | 6 | 4 | | | | | | | | | |
| LL | S Schenck | 0 | 0 | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 5 | R Anderson | 6 | 3 | 6 | | | | | | | | | | | | | | |
| | A Sutjiadi | 4 | 6 | 2 | 5 | R Anderson | 4 | 2 | | | | | | | | | | |
| Q | Z Hitt | 2 | 0 | | | C Alves | 6 | 6 | | | | | | | | | | |
| | C Alves | 6 | 6 | | | | | | | | C Alves | 4 | 7$^7$ | 6 | | | | |
| Q | E Douglas | 7$^7$ | 6 | | | | | | | Q | E Douglas | 6 | 6$^5$ | 1 | | | | |
| Q | K Christian | 6$^2$ | 2 | | Q | E Douglas | 7 | 5 | 6 | | | | | | | | | |
| WC | CS Martínez Solís | 0 | 1 | | 4 | A Hartono | 5 | 7 | 0 | | | | | | | | | |
| 4 | A Hartono | 6 | 6 | | | | | | | | | | | | | C Alves | 5 | 1 |
| 7 | V Grammatikopoulou | 6 | 2 | 6 | | | | | | | | | | | 2 | R Marino | 7 | 6 |
| | P Plipuech | 2 | 6 | 1 | 7 | V Grammatikopoulou | 2 | 1 | | | | | | | | | | |
| Q | MF Navarro | 4 | 2 | | | S Mendez | 6 | 6 | | | | | | | | | | |
| | S Mendez | 6 | 6 | | | | | | | | S Mendez | 5 | 1 | | | | | |
| | W Osuigwe | 7$^8$ | 6 | | | | | | | 2 | R Marino | 7 | 6 | | | | | |
| Q | J Hinojosa Gómez | 6$^6$ | 3 | | | W Osuigwe | 1 | 2 | | | | | | | | | | |
| SE | A Reami | 3 | 3 | | 2 | R Marino | 6 | 6 | | | | | | | | | | |
| 2 | R Marino | 6 | 6 | | | | | | | | | | | | | | | |