# 2022 Open Castilla y León – Singles

Benjamin Bonzi was the defending champion but chose not to defend his title.
Hugo Grenier won the title after defeating Constant Lestienne 7–5, 6–3 in the final.

## Seeds

* Nuno Borges (quarterfinals)
* Constant Lestienne (final)
* Fernando Verdasco (second round)
* Hugo Grenier (champion)
* Ugo Humbert (semifinals)
* Altuğ Çelikbilek (first round)
* Dmitry Popko (first round)
* Grégoire Barrère (quarterfinals)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| 5 | Ugo Humbert | 7$^7$ | 5 | 2 | | | | |
| 4 | Hugo Grenier | 6$^5$ | 7 | 6 | | | | |
| 4 | Hugo Grenier | 6$^5$ | 7 | 6 | 4 | Hugo Grenier | 7 | 6 |
| | | | | | 2 | Constant Lestienne | 5 | 3 |
| | Michael Geerts | 6 | 5 | 6$^4$ | 2 | Constant Lestienne | 5 | 3 |
| 2 | Constant Lestienne | 2 | 7 | 7$^7$ | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | N Borges | 6 | 6 | | | | | | | | | | | | | | |
| | M Bašić | 3 | 3 | | 1 | N Borges | 6 | 6 | | | | | | | | | |
| Q | A Kachmazov | 0 | 6 | 7$^7$ | Q | A Kachmazov | 1 | 2 | | | | | | | | | |
| Q | D Istomin | 6 | 4 | 6$^4$ | | | | | 1 | N Borges | 6$^6$ | 4 | | | | | |
| | D Masur | 6 | 6 | | | | | | 5 | U Humbert | 7$^8$ | 6 | | | | | |
| | E Donskoy | 4 | 4 | | | D Masur | 3 | 3 | | | | | | | | | |
| Q | G Décamps | 3 | 4 | | 5 | U Humbert | 6 | 6 | | | | | | | | | |
| 5 | U Humbert | 6 | 6 | | | | | | | | | | 5 | U Humbert | 7$^7$ | 5 | 2 |
| 4 | H Grenier | 6 | 6 | | | | | | | | | | 4 | H Grenier | 6$^5$ | 7 | 6 |
| WC | A Moro Cañas | 4 | 3 | | 4 | H Grenier | 6 | 6 | | | | | | | | | |
| Q | A Menéndez Maceiras | 2 | 4 | | | N Kuhn | 4 | 4 | | | | | | | | | |
| | N Kuhn | 6 | 6 | | | | | | 4 | H Grenier | 6 | 6 | | | | | |
| Alt | N Álvarez Varona | 7 | 5 | 1 | | | | | 8 | G Barrère | 2 | 2 | | | | | |
| | A Bellier | 5 | 7 | 6 | | A Bellier | 4 | 4 | | | | | | | | | |
| | E Karlovskiy | 1 | 3 | | 8 | G Barrère | 6 | 6 | | | | | | | | | |
| 8 | G Barrère | 6 | 6 | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 7 | D Popko | 4 | 4 | | | | | | | | | | | | | | | | |
| | M Geerts | 6 | 6 | | | M Geerts | 6 | 6 | | | | | | | | | | | |
| SE | D Yevseyev | 6 | 5 | 6 | SE | D Yevseyev | 4 | 3 | | | | | | | | | | | |
| WC | D Rincón | 2 | 7 | 3 | | | | | | | M Geerts | 6 | 6 | | | | | | |
| | P Jubb | 6$^5$ | 2 | | | | | | | | Em Nava | 4 | 4 | | | | | | |
| | Em Nava | 7$^7$ | 6 | | | Em Nava | 7$^{10}$ | 7 | | | | | | | | | | | |
| | H Moriya | 4 | 2 | | 3 | F Verdasco | 6$^8$ | 5 | | | | | | | | | | | |
| 3 | F Verdasco | 6 | 6 | | | | | | | | | | | | | M Geerts | 6 | 5 | 6$^4$ |
| 6 | A Çelikbilek | 0 | 2 | | | | | | | | | | | | 2 | C Lestienne | 2 | 7 | 7$^7$ |
| Q | B Lock | 6 | 6 | | Q | B Lock | 7$^8$ | 2 | 6 | | | | | | | | | | |
| | A Kuznetsov | 7$^7$ | 1 | 3 | Alt | I Marchenko | 6$^6$ | 6 | 3 | | | | | | | | | | |
| Alt | I Marchenko | 6$^4$ | 6 | 6 | | | | | | Q | B Lock | 6$^8$ | 6 | 3 | | | | | |
| | A Escoffier | 6 | 6 | | | | | | | 2 | C Lestienne | 7$^{10}$ | 4 | 6 | | | | | |
| WC | Julio César Porras | 2 | 3 | | | A Escoffier | 3 | 3 | | | | | | | | | | | |
| Q | A Barroso Campos | 6 | 2 | 4 | 2 | C Lestienne | 6 | 6 | | | | | | | | | | | |
| 2 | C Lestienne | 4 | 6 | 6 | | | | | | | | | | | | | | | |