# 2022 Open Città della Disfida – Singles

Giulio Zeppieri was the defending champion but lost in the first round to Matteo Arnaldi.
Nuno Borges won the title after defeating Miljan Zekić 6–3, 7–5 in the final.

## Seeds

* Gilles Simon (first round)
* Nuno Borges (champion)
* Zdeněk Kolář (semifinals)
* Jurij Rodionov (first round)
* Franco Agamenone (first round)
* Enzo Couacaud (second round)
* Constant Lestienne (first round)
* Kacper Żuk (first round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| WC | Luca Nardi | 7$^7$ | 5 | 6$^2$ | | | | |
| Q | Miljan Zekić | 6$^4$ | 7 | 7$^7$ | | | | |
| Q | Miljan Zekić | 6$^4$ | 7 | 7$^7$ | Q | Miljan Zekić | 3 | 5 |
| | | | | | 2 | Nuno Borges | 6 | 7 |
| 3 | Zdeněk Kolář | 6$^7$ | 3 | | 2 | Nuno Borges | 6 | 7 |
| 2 | Nuno Borges | 7$^9$ | 6 | | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | G Simon | 2 | 6 | 4 | | | | | | | | | | | | | | |
| | M Copil | 6 | 4 | 6 | | M Copil | | | | | | | | | | | | |
| WC | L Nardi | 6 | 6 | | WC | L Nardi | w/o | | | | | | | | | | | |
| | A Müller | 1 | 4 | | | | | | | WC | L Nardi | 6 | 6 | | | | | |
| Q | M Arnaldi | 0 | 7$^7$ | 7$^7$ | | | | | | | G Blancaneaux | 2 | 4 | | | | | |
| | G Zeppieri | 6 | 6$^4$ | 6$^4$ | Q | M Arnaldi | 3 | 4 | | | | | | | | | | |
| | G Blancaneaux | 6 | 6$^4$ | 6 | | G Blancaneaux | 6 | 6 | | | | | | | | | | |
| 8 | K Żuk | 4 | 7$^7$ | 3 | | | | | | | | | | WC | L Nardi | 7$^7$ | 5 | 6$^2$ |
| 4 | J Rodionov | 0 | 2 | | | | | | | | | | | Q | M Zekić | 6$^4$ | 7 | 7$^7$ |
| | R Bonadio | 6 | 6 | | | R Bonadio | 6 | 6$^6$ | 0$^r$ | | | | | | | | | |
| Alt | A Shevchenko | 2 | 6 | 6 | Alt | A Shevchenko | 3 | 7$^8$ | 3 | | | | | | | | | |
| | D Svrčina | 6 | 0 | 2 | | | | | | Alt | A Shevchenko | 4 | 4 | | | | | |
| Q | M Zekić | 2 | 6 | 6 | | | | | | Q | M Zekić | 6 | 6 | | | | | |
| | A Arnaboldi | 6 | 4 | 0 | Q | M Zekić | 2 | 7$^{12}$ | 6 | | | | | | | | | |
| WC | F Passaro | 6 | 6 | | WC | F Passaro | 6 | 6$^{10}$ | 0 | | | | | | | | | |
| 5 | F Agamenone | 4 | 3 | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 7 | C Lestienne | 7 | 4 | 0 | | | | | | | | | | | | | | |
| Alt | J Sels | 5 | 6 | 6 | Alt | J Sels | 5 | 6 | 7 | | | | | | | | | |
| | G Barrère | 3 | 3 | | | N Fatić | 7 | 1 | 5 | | | | | | | | | |
| | N Fatić | 6 | 6 | | | | | | | Alt | J Sels | 7 | 5 | 1 | | | | |
| Q | Lucas Gerch | 6 | 3 | 3 | | | | | | 3 | Z Kolář | 5 | 7 | 6 | | | | |
| | A Pellegrino | 2 | 6 | 6 | | A Pellegrino | 3 | 2 | | | | | | | | | | |
| Q | F Forti | 2 | 0 | | 3 | Z Kolář | 6 | 6 | | | | | | | | | | |
| 3 | Z Kolář | 6 | 6 | | | | | | | | | | | | 3 | Z Kolář | 6$^7$ | 3 |
| 6 | E Couacaud | 6 | 6 | | | | | | | | | | | | 2 | N Borges | 7$^9$ | 6 |
| | L Giustino | 4 | 4 | | 6 | E Couacaud | 6 | 6$^1$ | 2 | | | | | | | | | |
| Alt | E Karlovskiy | 7$^7$ | 3 | 3 | Q | L Darderi | 4 | 7$^7$ | 6 | | | | | | | | | |
| Q | L Darderi | 6$^3$ | 6 | 6 | | | | | | Q | L Darderi | 6 | 6$^4$ | 1 | | | | |
| | L Rosol | 5 | 6 | 3 | | | | | | 2 | N Borges | 1 | 7$^7$ | 6 | | | | |
| WC | O Ovcharenko | 7 | 2 | 6 | WC | O Ovcharenko | 6$^3$ | 4 | | | | | | | | | | |
| Q | T Droguet | 1 | 4 | | 2 | N Borges | 7$^7$ | 6 | | | | | | | | | | |
| 2 | N Borges | 6 | 6 | | | | | | | | | | | | | | | |