# 2001 Sybase Open – Singles

Mark Philippoussis was the defending champion but lost in the second round to Juan Balcells.
Greg Rusedski won in the final 6–3, 6–4 against Andre Agassi.

## Seeds

A champion seed is indicated in bold text while text in italics indicates the round in which that seed was eliminated.
* Andre Agassi (final)
* Lleyton Hewitt (quarterfinals)
* Mark Philippoussis (second round)
* Tommy Haas (quarterfinals)
* Sjeng Schalken (first round)
* Jan-Michael Gambill (semifinals)
* n/a
* Greg Rusedski (champion)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking
| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| WC/1 | A Agassi | 7 | 3 | 6 | | | | | | | | | | | | | | | | | | |
| | H-T Lee | 5 | 6 | 3 | WC/1 | A Agassi | 6 | 6 | | | | | | | | | | | | | | |
| | M Kratochvil | 6 | 6 | | | M Kratochvil | 4 | 2 | | | | | | | | | | | | | | |
| | D Sanguinetti | 2 | 0 | | | | | | | WC/1 | A Agassi | 6 | 6 | | | | | | | | | |
| | J Gimelstob | 1 | 6$^5$ | | | | | | | | S Sargsian | 1 | 3 | | | | | | | | | |
| | S Sargsian | 6 | 7$^7$ | | | S Sargsian | 6 | 6$^5$ | 7$^7$ | | | | | | | | | | | | | |
| | W Arthurs | 6 | 6 | | | W Arthurs | 4 | 7$^7$ | 6$^2$ | | | | | | | | | | | | | |
| 5 | S Schalken | 4 | 4 | | | | | | | | | | | | WC/1 | A Agassi | 6 | 6 | | | | |
| 3 | M Philippoussis | 6 | 6$^7$ | 6 | | | | | | | | | | | 6 | J-M Gambill | 4 | 4 | | | | |
| | M Hantschk | 3 | 7$^9$ | 3 | 3 | M Philippoussis | 4 | 7$^7$ | 6$^3$ | | | | | | | | | | | | | |
| SE | J Acasuso | 5 | 1 | | | J Balcells | 6 | 6$^4$ | 7$^7$ | | | | | | | | | | | | | |
| | J Balcells | 7 | 6 | | | | | | | | J Balcells | 2 | 0 | | | | | | | | | |
| WC | A Roddick | 6 | 6 | | | | | | | 6 | J-M Gambill | 6 | 6 | | | | | | | | | |
| | C Woodruff | 4 | 4 | | WC | A Roddick | 6$^5$ | 6$^1$ | | | | | | | | | | | | | | |
| | A Sá | 3 | 7$^7$ | 3 | 6 | J-M Gambill | 7$^7$ | 7$^7$ | | | | | | | | | | | | | | |
| 6 | J-M Gambill | 6 | 6$^0$ | 6 | | | | | | | | | | | | | | | WC/1 | Andre Agassi | 3 | 4 |
| LL | C Mamiit | 2 | 2 | | | | | | | | | | | | | | | | 8 | Greg Rusedski | 6 | 6 |
| WC | G Ivanišević | 6 | 6 | | WC | G Ivanišević | 3 | 4 | | | | | | | | | | | | | | |
| | P Goldstein | 3 | 6$^4$ | | Q | X Malisse | 6 | 6 | | | | | | | | | | | | | | |
| Q | X Malisse | 6 | 7$^7$ | | | | | | | Q | X Malisse | 5 | 6 | 5 | | | | | | | | |
| | M Gustafsson | 3 | 6 | 6 | | | | | | 4 | T Haas | 7 | 3 | 1/r | | | | | | | | |
| | A Gaudenzi | 6 | 3 | 2 | | M Gustafsson | 6 | 3 | 4 | | | | | | | | | | | | | |
| | C Vinck | 4 | 5 | | 4 | T Haas | 4 | 6 | 6 | | | | | | | | | | | | | |
| 4 | T Haas | 6 | 7 | | | | | | | | | | | | Q | X Malisse | 4 | 2 | | | | |
| 8 | G Rusedski | 6 | 7$^7$ | | | | | | | | | | | | 8 | G Rusedski | 6 | 6 | | | | |
| | H Levy | 1 | 6$^4$ | | 8 | G Rusedski | 6 | 6 | | | | | | | | | | | | | | |
| Q | R Furlan | 6 | 7 | | Q | R Furlan | 3 | 2 | | | | | | | | | | | | | | |
| Q | T Zíb | 2 | 5 | | | | | | | 8 | G Rusedski | 5 | 6 | 6 | | | | | | | | |
| | A Stoliarov | 6 | 6 | | | | | | | 2 | L Hewitt | 7 | 1 | 4 | | | | | | | | |
| Q | R Delgado | 2 | 2 | | | A Stoliarov | 2 | 7$^{10}$ | 3 | | | | | | | | | | | | | |
| SE | S Lareau | 3 | 1 | | 2 | L Hewitt | 6 | 6$^8$ | 6 | | | | | | | | | | | | | |
| 2 | L Hewitt | 6 | 6 | | | | | | | | | | | | | | | | | | | |