# IIT Research Institute

IIT Research Institute (IITRI), also known historically and interchangeably as IIT Research Center, is a high-technology scientific research organization and applied research laboratory located in Chicago, Illinois. Previously known as the Armour Research Foundation, the IITRI is an independent corporation that operates collaboratively with the Illinois Institute of Technology (IIT) and the U.S. Government.

## History of IITRI

IITRI was formed in 1936 as the Armour Research Foundation (ARF), and was renamed IITRI in 1963. Initially, ARF was formed to support the research endeavors of faculty members from the Armour Institute of Technology, predecessor to the Illinois Institute of Technology (IIT).
IITRI is headquartered on the IIT campus in Chicago, but operates as an independent, not-for-profit research organization. Between its founding in 1936 and 2000, IITRI developed research operations in approximately two dozen locations across the United States. The IITRI staff grew to approximately 1700 employees who performed research and development programs with an annual research budget exceeding $200 M per year. Historically, as a major national science research center, work involved both unclassified and classified (secret) research.
In 2002, IITRI became entirely focused on the life sciences. All other science and engineering divisions were spun off into Alion Science and Technology, a separate employee-owned corporation. Since 2002, research at IITRI has been entirely focused on biomedical research, with particular emphasis on pre-clinical toxicology, safety evaluations, and drug discovery and development.
In 2006, IITRI formed Technology Research, Inc. (TRI), as a wholly owned subsidiary in which research programs that fall outside of IITRI's not-for-profit charter can be conducted.

### Research history

Research and development programs explored as an engineering think tank over the decades have involved many areas of science, including applied physics, high energy physics, upper atmosphere research (aeronomy), nuclear physics, nuclear attack survival, numerical and computer simulations, electron microscopes and microscopy, police technologies, military, luminescence, aerosols, spacecraft thermal protective coatings, material effects by solar radiation, energy work, and mining engineering. The invention of the modern cellphone was developed here. Early research into magnetics here would cause the development of early wire recorders (fostering modern tape recording), and later the new field of computer science.

### Patents

Numerous patents over the decades have resulted from work by its researchers, including as an assignee under "IIT Research Institute".

### Awards

Several of its engineer scientists have distinguished themselves as recipients of the National Medal of Technology or the National Medal of Science, in addition to other awards.

## Current activities

Current investigations at IITRI are focused on biomedicine as a contract research organization (CRO), with particular emphasis on non-clinical toxicology, inhalation toxicology and technology, microbiology and molecular biology, and drug discovery and development for cancer and infectious diseases. IITRI conducts research programs with particular emphasis on studies to support Investigational New Drug applications and New Drug applications to the U.S. Food and Drug Administration.

## Current Divisions of IITRI

IITRI currently performs research in five Technical Divisions: Toxicology, Inhalation Toxicology, Microbiology and Molecular Biology, Carcinogenesis and Cancer Chemoprevention, and Drug Discovery.

### Toxicology

Scientists working in IITRI's Toxicology Division have performed non-clinical toxicology studies for U.S. Government and medical industry sponsors for more than thirty years. Current programs involve acute, subchronic and chronic studies in both rodent and non-rodent model systems to support new drug research. In addition to general toxicology studies, IITRI scientists routinely perform pharmacokinetics and metabolism (PK/ADME) studies, reproductive toxicology studies, safety pharmacology studies, and studies involving a variety of specializations and clinical endpoints. A particular strength of the scientific staff is the integration of non-routine evaluations (genomics/gene expression, cell biology, biochemistry, and enzymology) into the conduct of non-clinical toxicology protocols.

### Inhalation Toxicology

IITRI's Inhalation Toxicology Division integrates the efforts of doctoral-level inhalation scientists and engineers with experienced, doctoral-level toxicologists to conduct non-clinical toxicology studies in support of Investigational New Drug (IND) and New Drug (NDA) Applications. Studies are performed in both rodent and non-rodent species.
Nose-only and whole body exposures are performed using metered dose inhalers, nebulizers, atomizers, powder dispensers, and vapor generation systems, with continuous on-line monitoring to document test atmosphere composition. Study endpoints are similar to those performed by scientists of the Toxicology Division, and commonly involve safety evaluations.
Safety Pharmacology studies are performed to determine the effects of drugs and other xeniobiotics on the function of the central nervous, respiratory, cardiovascular, and urinary/renal systems. Cardiovascular safety pharmacology studies are performed using telemetry instrumentation.

### Microbiology and Molecular Biology

Scientists working in IITRI's Microbiology and Molecular Biology Division work in genetic toxicology, immunotoxicology, applied microbiology, genomics and gene expression, and molecular diagnostics.
Genetic Toxicologists at IITRI routinely perform bacterial mutagenesis assays (Ames Tests), mammalian mutagenesis assays (mouse lymphoma and other tests), DNA damage assays (micronucleus and chromosomal aberration assays), and cytotoxicity assays.
Molecular biologists perform a wide range of studies in gene expression, including genomics evaluations using several different platforms.
IITRI has studied immunotoxicology for more than 25 years. In the early 1980s, IITRI scientists were key participants in the original tripartite program (with the NIEHS and the Medical College of Virginia) in which murine immunotoxicology bioassays were developed and validated. Subsequently, IITRI scientists played a major role in the development and validation of the local lymph node assay (LLNA) for the rapid detection of agents that induce hypersensitivity.
IITRI's Microbiology and Molecular Biology Division operates both Biosafety Level-2 and Biosafety Level-3 laboratories for in vitro and in vivo studies, and is approved by the United States Centers for Disease Control and Prevention (CDC) to conduct studies with a broad range of pathogenic agents. This work involves molecular diagnostics, drug and vaccine efficacy evaluations, drug and vaccine safety evaluations, and decontamination studies.

### Carcinogenesis and Cancer Chemoprevention

The focus of research efforts in Carcinogenesis and Cancer Chemoprevention Division is the prevention of cancer by pharmacologic, nutritional, or hormonal interventions. IITRI has done preclinical studies of cancer prevention for more than 30 years, and IITRI scientists have published more than 200 peer-reviewed papers in the field.
Originally focused entirely on the prevention of experimental breast cancer, scientists working in IITRI's Carcinogenesis and Chemoprevention Division have conducted studies directed at mechanisms of carcinogenesis and prevention of cancer in the breast, prostate, lung, colon, urinary bladder, oral cavity, liver, skin, and hematopoietic system, among other organ sites. The earliest studies conducted by this group (in the 1970s) focused on the prevention of cancer by natural and synthetic analogs of vitamin A (retinoids). This work has expanded substantially since that time, and currently involves a wide range of natural products (soy isoflavones and protease inhibitors, tea polyphenols, organic selenium compounds, vitamin D and derivatives), hormones and hormone analogs, and pharmacologic agents originally developed for other indications. Mechanistic studies are performed at the cell, biochemical, and molecular levels, and preclinical drug discovery and development studies involve a wide range of in vitro and in vivo screening, efficacy, and preclinical toxicology programs.

### Drug Discovery

The various research efforts in the foregoing divisions supports Drug Discovery Division with Investigational New Drug (IND) Applications and New Drug Applications (NDA) to the U.S. Food and Drug Administration, as well as submissions to other regulatory agencies. Studies comply with Good Laboratory Practice (GLP) regulations. IITRI's expertise in non-clinical studies also supports the development of drugs for cancer prevention and therapy.