# 2023 Santa Cruz Challenger – Singles

Paul Jubb was the defending champion but chose not to defend his title.
Mariano Navone won the title after defeating Francisco Comesaña 4–6, 7–5, 6–1 in the final.

## Seeds

* Juan Manuel Cerúndolo (semifinals, retired)
* Genaro Alberto Olivieri (quarterfinals)
* Hugo Dellien (first round)
* Thiago Agustín Tirante (quarterfinals, retired)
* Francisco Comesaña (final)
* Mariano Navone (champion)
* Luciano Darderi (first round)
* Camilo Ugo Carabelli (second round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final | Final |
| 1 | Juan Manuel Cerúndolo | 4 | 0$^r$ | | | | | | |
| 6 | Mariano Navone | 6 | 3 | | | | | | |
| 6 | Mariano Navone | 6 | 3 | | 6 | Mariano Navone | 4 | 7 | 6 |
| | | | | | 5 | Francisco Comesaña | 6 | 5 | 1 |
| | Andrea Collarini | 7 | 4 | 4 | 5 | Francisco Comesaña | 6 | 5 | 1 |
| 5 | Francisco Comesaña | 5 | 6 | 6 | | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | JM Cerúndolo | 6 | 6 | | | | | | | | | | | | | | |
| | Alex Barrena | 2 | 3 | | 1 | JM Cerúndolo | 7$^7$ | 4 | 7$^8$ | | | | | | | | |
| Q | O Luz | 7 | 6 | | Q | O Luz | 6$^2$ | 6 | 6$^6$ | | | | | | | | |
| | B Kuzuhara | 5 | 2 | | | | | | | 1 | JM Cerúndolo | 7 | 6 | | | | |
| | T Boyer | 4 | 4 | | | | | | | PR | P Sakamoto | 5 | 4 | | | | |
| PR | P Sakamoto | 6 | 6 | | PR | P Sakamoto | 4 | 7$^7$ | 6 | | | | | | | | |
| | JL Reis da Silva | 6 | 6 | | | JL Reis da Silva | 6 | 6$^4$ | 2 | | | | | | | | |
| 7 | L Darderi | 4 | 3 | | | | | | | | | | | 1 | JM Cerúndolo | 4 | 0$^r$ |
| 4 | TA Tirante | 2 | 6 | 2 | | | | | | | | | | 6 | M Navone | 6 | 3 |
| | D Dutra da Silva | 6 | 3 | 0$^r$ | 4 | TA Tirante | 7$^7$ | 7$^7$ | | | | | | | | | |
| | M Pucinelli de Almeida | 6 | 6 | | | M Pucinelli de Almeida | 6$^1$ | 6$^3$ | | | | | | | | | |
| Q | M Zormann | 4 | 4 | | | | | | | 4 | TA Tirante | 1 | 1$^r$ | | | | |
| WC | JC Prado Ángelo | 6 | 6 | | | | | | | 6 | M Navone | 6 | 4 | | | | |
| | AD Vallejo | 3 | 1 | | WC | JC Prado Ángelo | 3 | 3 | | | | | | | | | |
| WC | M Soto | 7 | 6$^4$ | 1 | 6 | M Navone | 6 | 6 | | | | | | | | | |
| 6 | M Navone | 5 | 7$^7$ | 6 | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 8 | C Ugo Carabelli | 6 | 6 | | | | | | | | | | | | | | | |
| | M Dellien | 2 | 4 | | 8 | C Ugo Carabelli | 4 | 5 | | | | | | | | | | |
| Q | F Mena | 6 | 6 | | Q | F Mena | 6 | 7 | | | | | | | | | | |
| Q | P Boscardin Dias | 4 | 4 | | | | | | | Q | F Mena | 3 | 6$^6$ | | | | | |
| WC | JI Londero | 7$^7$ | 6 | | | | | | | | A Collarini | 6 | 7$^8$ | | | | | |
| | R Olivo | 6$^4$ | 2 | | WC | JI Londero | | | | | | | | | | | | |
| | A Collarini | 7$^7$ | 6 | | | A Collarini | w/o | | | | | | | | | | | |
| 3 | H Dellien | 6$^4$ | 4 | | | | | | | | | | | | A Collarini | 7 | 4 | 4 |
| 5 | F Comesaña | 6 | 6 | | | | | | | | | | | 5 | F Comesaña | 5 | 6 | 6 |
| | E Ribeiro | 2 | 4 | | 5 | F Comesaña | 6 | 7 | | | | | | | | | | |
| | D Jordà Sanchis | 0 | 6 | 5 | | G Heide | 3 | 5 | | | | | | | | | | |
| | G Heide | 6 | 3 | 7 | | | | | | 5 | F Comesaña | 6 | 6 | | | | | |
| Q | G Villanueva | 7$^7$ | 6 | | | | | | | 2 | GA Olivieri | 4 | 1 | | | | | |
| Q | J Pereira | 6$^4$ | 2 | | Q | G Villanueva | 4 | 6 | 1 | | | | | | | | | |
| | RA Burruchaga | 6 | 6$^3$ | 2 | 2 | GA Olivieri | 6 | 3 | 6 | | | | | | | | | |
| 2 | GA Olivieri | 1 | 7$^7$ | 6 | | | | | | | | | | | | | | |