# 2022 Santa Cruz Challenger – Singles

This was the first edition of the tournament as part of the Legión Sudamericana.
Francisco Cerúndolo won the title after defeating Camilo Ugo Carabelli 6–4, 6–3 in the final.

## Seeds

* Hugo Dellien (semifinals)
* Andrej Martin (first round)
* Francisco Cerúndolo (champion)
* Tomás Martín Etcheverry (first round, retired)
* Zdeněk Kolář (second round)
* Fernando Verdasco (quarterfinals)
* Facundo Mena (second round)
* Camilo Ugo Carabelli (final)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| 1 | Hugo Dellien | 6 | 4 | 3 | | | | |
| 3 | Francisco Cerúndolo | 1 | 6 | 6 | | | | |
| 3 | Francisco Cerúndolo | 1 | 6 | 6 | 3 | Francisco Cerúndolo | 6 | 6 |
| | | | | | 8 | Camilo Ugo Carabelli | 4 | 3 |
| 8 | Camilo Ugo Carabelli | 6 | 6 | | 8 | Camilo Ugo Carabelli | 4 | 3 |
| Q | Pedro Cachin | 3 | 2 | | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | H Dellien | 7 | 7 | | | | | | | | | | | | | | | |
| | S Rodríguez Taverna | 5 | 5 | | 1 | H Dellien | 6$^4$ | 7$^7$ | 6 | | | | | | | | | |
| Q | MF Descotte | 7$^7$ | 2 | 2 | | D Dutra da Silva | 7$^7$ | 6$^3$ | 3 | | | | | | | | | |
| | D Dutra da Silva | 6$^3$ | 6 | 6 | | | | | | 1 | H Dellien | 6 | 6 | | | | | |
| Q | D Hidalgo | 3 | 5 | | | | | | | Alt | N Álvarez | 1 | 4 | | | | | |
| Alt | N Álvarez | 6 | 7 | | Alt | N Álvarez | 6$^4$ | 6 | 6 | | | | | | | | | |
| Q | G Villanueva | 5 | 6 | 2 | 5 | Z Kolář | 7$^7$ | 3 | 4 | | | | | | | | | |
| 5 | Z Kolář | 7 | 4 | 6 | | | | | | | | | | 1 | H Dellien | 6 | 4 | 3 |
| 3 | F Cerúndolo | 7$^7$ | 2 | 6 | | | | | | | | | | 3 | F Cerúndolo | 1 | 6 | 6 |
| | F Díaz Acosta | 6$^4$ | 6 | 3 | 3 | F Cerúndolo | 6 | 3 | 7$^7$ | | | | | | | | | |
| Q | JC Prado Ángelo | 4 | 4 | | | TA Tirante | 3 | 6 | 6$^5$ | | | | | | | | | |
| | TA Tirante | 6 | 6 | | | | | | | 3 | F Cerúndolo | 6 | 6 | | | | | |
| WC | F Zeballos | 5 | 2 | | | | | | | | N Moreno de Alboran | 3 | 4 | | | | | |
| | N Moreno de Alboran | 7 | 6 | | | N Moreno de Alboran | 6$^4$ | 6 | 6 | | | | | | | | | |
| | GA Olivieri | 1 | 1 | | 7 | F Mena | 7$^7$ | 4 | 1 | | | | | | | | | |
| 7 | F Mena | 6 | 6 | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 8 | C Ugo Carabelli | 6 | 6 | | | | | | | | | | | | | | |
| | O Luz | 2 | 4 | | 8 | C Ugo Carabelli | 6 | 6 | | | | | | | | | |
| WC | B Arias | 3 | 2 | | Q | C Rodríguez | 3 | 3 | | | | | | | | | |
| Q | C Rodríguez | 6 | 6 | | | | | | | 8 | C Ugo Carabelli | 7 | 6 | | | | |
| | D King | 4 | 5 | | | | | | | WC | M Dellien | 5 | 3 | | | | |
| WC | M Dellien | 6 | 7 | | WC | M Dellien | 4 | 6 | 6 | | | | | | | | |
| | F Comesaña | 4 | 7 | 1 | | F Comesaña | 6 | 4 | 0 | | | | | | | | |
| 4 | TM Etcheverry | 6 | 5 | 0$^r$ | | | | | | | | | | 8 | C Ugo Carabelli | 6 | 6 |
| 6 | F Verdasco | 6 | 6 | | | | | | | | | | | Q | P Cachin | 3 | 2 |
| | M Pucinelli de Almeida | 4 | 1 | | 6 | F Verdasco | 6 | 6$^4$ | 7$^7$ | | | | | | | | |
| | JP Ficovich | 6 | 6 | | | JP Ficovich | 3 | 7$^7$ | 6$^3$ | | | | | | | | |
| LL | Michel Vernier | 1 | 3 | | | | | | | 6 | F Verdasco | 3 | 1 | | | | |
| | G Lama | 7$^7$ | 7$^7$ | | | | | | | Q | P Cachin | 6 | 6 | | | | |
| | C Gómez-Herrera | 6$^4$ | 6$^3$ | | | G Lama | 6 | 3 | 3 | | | | | | | | |
| Q | P Cachin | 6 | 6 | | Q | P Cachin | 4 | 6 | 6 | | | | | | | | |
| 2 | A Martin | 2 | 4 | | | | | | | | | | | | | | |