# 2021 Internazionali di Tennis Città di Todi – Singles

Yannick Hanfmann was the defending champion but chose not to defend his title.
Mario Vilella Martínez won the title after defeating Federico Gaio 7–6$^{(7–3)}$, 1–6, 6–3 in the final.

## Seeds

* Federico Gaio (final)
* Mario Vilella Martínez (champion)
* Dmitry Popko (second round)
* Tomás Martín Etcheverry (semifinals)
* Renzo Olivo (first round)
* Andrea Collarini (second round)
* Gian Marco Moroni (first round)
* Lorenzo Giustino (first round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final | Final |
| 1 | Federico Gaio | 6 | 6 | | | | | | |
| 4 | Tomás Martín Etcheverry | 2 | 2 | | | | | | |
| 4 | Tomás Martín Etcheverry | 2 | 2 | | 1 | Federico Gaio | 6$^3$ | 6 | 3 |
| | | | | | 2 | Mario Vilella Martínez | 7$^7$ | 1 | 6 |
| Q | Matheus Pucinelli de Almeida | 6$^4$ | 6 | 1 | 2 | Mario Vilella Martínez | 7$^7$ | 1 | 6 |
| 2 | Mario Vilella Martínez | 7$^7$ | 3 | 6 | | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | F Gaio | 6 | 6 | | | | | | | | | | | | | | |
| PR | V Galović | 3 | 2 | | 1 | F Gaio | 6$^1$ | 6 | 7$^7$ | | | | | | | | |
| Alt | S Mansouri | 3 | 2 | | | TA Tirante | 7$^7$ | 1 | 6$^2$ | | | | | | | | |
| | TA Tirante | 6 | 6 | | | | | | | 1 | F Gaio | 7 | 6 | | | | |
| WC | F Cobolli | 3 | 6 | 6 | | | | | | WC | F Cobolli | 5 | 4 | | | | |
| | P Sakamoto | 6 | 4 | 3 | WC | F Cobolli | 6 | 6 | | | | | | | | | |
| | J Domingues | 2 | 3 | | 6 | A Collarini | 4 | 3 | | | | | | | | | |
| 6 | A Collarini | 6 | 6 | | | | | | | | | | | 1 | F Gaio | 6 | 6 |
| 4 | TM Etcheverry | 6 | 7$^7$ | | | | | | | | | | | 4 | TM Etcheverry | 2 | 2 |
| | M Viola | 4 | 6$^4$ | | 4 | TM Etcheverry | 2 | 6 | 4 | | | | | | | | |
| | J Ocleppo | 3 | 6 | 4 | Q | M Arnaldi | 6 | 3 | 1$^r$ | | | | | | | | |
| Q | M Arnaldi | 6 | 1 | 6 | | | | | | 4 | TM Etcheverry | 6 | 6 | | | | |
| | A Arnaboldi | 1 | 6$^4$ | | | | | | | | A Ritschard | 1 | 1 | | | | |
| | A Ritschard | 6 | 7$^7$ | | | A Ritschard | 6 | 6 | | | | | | | | | |
| Q | G Fonio | 6 | 6 | | Q | G Fonio | 3 | 4 | | | | | | | | | |
| 8 | L Giustino | 4 | 3 | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 7 | GM Moroni | 0 | 3 | | | | | | | | | | | | | | | | |
| | N Jarry | 6 | 6 | | | N Jarry | 4 | 6 | 7 | | | | | | | | | | |
| | P Cachin | 6 | 6 | | | P Cachin | 6 | 4 | 5 | | | | | | | | | | |
| Alt | F Díaz Acosta | 3 | 4 | | | | | | | | N Jarry | 6 | 3 | 1 | | | | | |
| | F Baldi | 6 | 4 | 1 | | | | | | Q | M Pucinelli de Almeida | 3 | 6 | 6 | | | | | |
| Q | M Pucinelli de Almeida | 1 | 6 | 6 | Q | M Pucinelli de Almeida | 3 | 6 | 6 | | | | | | | | | | |
| WC | F Passaro | 7 | 2 | 2 | 3 | D Popko | 6 | 1 | 2 | | | | | | | | | | |
| 3 | D Popko | 5 | 6 | 6 | | | | | | | | | | | Q | M Pucinelli de Almeida | 6$^4$ | 6 | 1 |
| 5 | R Olivo | 6$^5$ | 4 | | | | | | | | | | | | 2 | M Vilella Martínez | 7$^7$ | 3 | 6 |
| Q | A Cazaux | 7$^7$ | 6 | | Q | A Cazaux | 3 | 3 | | | | | | | | | | | |
| | A Pellegrino | 6$^2$ | 6$^4$ | | | G Zeppieri | 6 | 6 | | | | | | | | | | | |
| | G Zeppieri | 7$^7$ | 7$^7$ | | | | | | | | G Zeppieri | 3 | 3 | | | | | | |
| WC | F Forti | 6 | 6$^5$ | 6 | | | | | | 2 | M Vilella Martínez | 6 | 6 | | | | | | |
| LL | F Agamenone | 2 | 7$^7$ | 3 | WC | F Forti | 3 | 1 | | | | | | | | | | | |
| | T Lamasine | 2 | 6$^4$ | | 2 | M Vilella Martínez | 6 | 6 | | | | | | | | | | | |
| 2 | M Vilella Martínez | 6 | 7$^7$ | | | | | | | | | | | | | | | | |