# 2021 Orlando Open – Singles

Brandon Nakashima was the defending champion but chose not to defend his title.
Jenson Brooksby won the title after defeating Denis Kudla 6–3, 6–3 in the final.

## Seeds

* Steve Johnson (first round)
* Yasutaka Uchiyama (second round)
* Mackenzie McDonald (first round)
* Thiago Seyboth Wild (second round)
* Denis Kudla (final)
* Prajnesh Gunneswaran (second round)
* Jason Jung (first round)
* Alejandro Tabilo (first round)

## Draw
### Key

* Q = Qualifier
* WC = Wild card
* LL = Lucky loser
* Alt = Alternate
* SE = Special exempt
* PR = Protected ranking
* ITF = ITF entry
* JE = Junior exempt
* w/o = Walkover
* r = Retired
* d = Defaulted
* SR = Special ranking

### Finals

| Semifinals | Semifinals | Semifinals | Semifinals | Semifinals | Final | Final | Final | Final |
| 5 | Denis Kudla | 2 | 6 | 6 | | | | |
| | Roberto Cid Subervi | 6 | 2 | 2 | | | | |
| | Roberto Cid Subervi | 6 | 2 | 2 | 5 | Denis Kudla | 3 | 3 |
| | | | | | | Jenson Brooksby | 6 | 6 |
| WC | Christian Harrison | 5 | 1 | | | Jenson Brooksby | 6 | 6 |
| | Jenson Brooksby | 7 | 6 | | | | | |

### Top half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 1 | S Johnson | 1 | 6$^3$ | | | | | | | | | | | | | | | | |
| | C Eubanks | 6 | 7$^7$ | | | C Eubanks | 6 | 3 | 2 | | | | | | | | | | |
| | M Mmoh | 6 | 4 | 6 | | M Mmoh | 3 | 6 | 6 | | | | | | | | | | |
| Q | M Damm | 4 | 6 | 1 | | | | | | | M Mmoh | 5 | 3 | | | | | | |
| | M Krueger | 3 | 4 | | | | | | | 5 | D Kudla | 7 | 6 | | | | | | |
| Q | T van Rijthoven | 6 | 6 | | Q | T van Rijthoven | 7 | 2 | 5 | | | | | | | | | | |
| | J Menezes | 2 | 2 | | 5 | D Kudla | 5 | 6 | 7 | | | | | | | | | | |
| 5 | D Kudla | 6 | 6 | | | | | | | | | | | | 5 | D Kudla | 2 | 6 | 6 |
| 4 | T Seyboth Wild | 6 | 6 | | | | | | | | | | | | | R Cid Subervi | 6 | 2 | 2 |
| | F Mena | 2 | 0 | | 4 | T Seyboth Wild | 6$^2$ | 2 | | | | | | | | | | | |
| | M Torpegaard | 6$^2$ | 3 | | | R Cid Subervi | 7$^7$ | 6 | | | | | | | | | | | |
| | R Cid Subervi | 7$^7$ | 6 | | | | | | | | R Cid Subervi | 3 | 6 | 4 | | | | | |
| | E Gómez | 6 | 4 | 1 | | | | | | | B Schnur | 6 | 2 | 0$^r$ | | | | | |
| | B Fratangelo | 3 | 6 | 6 | | B Fratangelo | 3 | 6$^2$ | | | | | | | | | | | |
| | B Schnur | 6 | 6 | | | B Schnur | 6 | 7$^7$ | | | | | | | | | | | |
| 8 | A Tabilo | 2 | 2 | | | | | | | | | | | | | | | | |

### Bottom half

| First round | First round | First round | First round | First round | Second round | Second round | Second round | Second round | Quarterfinals | Quarterfinals | Quarterfinals | Quarterfinals | Semifinals | Semifinals | Semifinals | Semifinals |
| 6 | P Gunneswaran | 6 | 6 | | | | | | | | | | | | | |
| | M Ebden | 4 | 1 | | 6 | P Gunneswaran | 3 | 4 | | | | | | | | |
| | Yo Watanuki | 1 | 1 | | | J Sock | 6 | 6 | | | | | | | | |
| | J Sock | 6 | 6 | | | | | | | J Sock | 6$^3$ | 3 | | | | |
| WC | A Kovacevic | 6 | 5 | 6 | | | | | WC | C Harrison | 7$^7$ | 6 | | | | |
| Q | R Quiroz | 1 | 7 | 4 | WC | A Kovacevic | 4 | 3 | | | | | | | | |
| WC | C Harrison | 7 | 6 | | WC | C Harrison | 6 | 6 | | | | | | | | |
| 3 | M McDonald | 5 | 3 | | | | | | | | | | WC | C Harrison | 5 | 1 |
| 7 | J Jung | 1 | 4 | | | | | | | | | | | J Brooksby | 7 | 6 |
| | J Brooksby | 6 | 6 | | | J Brooksby | 6 | 6 | | | | | | | | |
| | T-S Kwiatkowski | 2 | 3 | | Q | A Çelikbilek | 3 | 1 | | | | | | | | |
| Q | A Çelikbilek | 6 | 6 | | | | | | | J Brooksby | 6 | 6 | | | | |
| WC | Z Khan | 6 | 1 | 6 | | | | | WC | Z Khan | 4 | 3 | | | | |
| LL | K King | 3 | 6 | 1 | WC | Z Khan | 7$^7$ | 7$^7$ | | | | | | | | |
| | P Polansky | 3 | 6 | 4 | 2 | Y Uchiyama | 6$^5$ | 6$^5$ | | | | | | | | |
| 2 | Y Uchiyama | 6 | 3 | 6 | | | | | | | | | | | | |